diff --git a/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/Ao2FUlFon80_postprocess.srt b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/Ao2FUlFon80_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..456cabd784a9a9d6bb4748a2472e1daba2650160
--- /dev/null
+++ b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/Ao2FUlFon80_postprocess.srt
@@ -0,0 +1,2820 @@
+1
+00:00:04,280 --> 00:00:08,880
+بسم الله الرحمن الرحيم سنتكلم
+
+2
+00:00:08,880 --> 00:00:11,320
+اليوم ان شاء الله في المحاضرة الرقم اربع عن ال
+
+3
+00:00:11,320 --> 00:00:17,020
+antibody structure and function ودعونا نستذكر سويا
+
+4
+00:00:17,020 --> 00:00:22,900
+يعني هذه المعلومات لان انا بعرف ان عندكم خلفية عن
+
+5
+00:00:22,900 --> 00:00:29,720
+هذا الموضوع ودعونا نبدأ ان شاء الله واتمنى ان تكون
+
+6
+00:00:29,720 --> 00:00:34,420
+في معلومات جيدة وجديدة لكمالمهم اللي أقوله بشكل
+
+7
+00:00:34,420 --> 00:00:40,180
+عام هو عبارة عن antibody بيوجد على شاكلتين في
+
+8
+00:00:40,180 --> 00:00:45,840
+الجسم إما secreted form وإما membrane bound ال
+
+9
+00:00:45,840 --> 00:00:52,980
+membrane bound هو عبارة عن ال antibody اللي موجودة
+
+10
+00:00:52,980 --> 00:00:57,560
+على سطح البيلين في ال size وغالبا هذا بيشتغل ك
+
+11
+00:00:57,560 --> 00:01:02,740
+antigen receptor بينما البلازمةهي اللى بتفرز انها
+
+12
+00:01:02,740 --> 00:01:10,080
+secreted form of antibody ال membrane bound غالبا
+
+13
+00:01:10,080 --> 00:01:14,760
+associated with يعني cognate molecule الهيتيرو
+
+14
+00:01:14,760 --> 00:01:17,620
+دايمر موليكول بيسموه ال amino globulin alpha beta
+
+15
+00:01:17,620 --> 00:01:28,840
+وهذا هو مع ال antibody يشكل بيس الرسبتور دول ال
+
+16
+00:01:28,840 --> 00:01:32,480
+amino globulin alpha betaهو الـ Intracellular
+
+17
+00:01:32,480 --> 00:01:37,000
+Signaling Mechanism associated with B lymphocytes
+
+18
+00:01:37,000 --> 00:01:41,720
+الـ Antibody كنا بنعرف أنه له Specificity وهي له
+
+19
+00:01:41,720 --> 00:01:46,920
+biological activity biological activity بتتمثل
+
+20
+00:01:46,920 --> 00:01:52,400
+بالآتي أنه it can neutralize the toxin immobilize
+
+21
+00:01:52,400 --> 00:01:56,260
+the microorganism neutralization of viral
+
+22
+00:01:56,260 --> 00:02:00,860
+infectivity agglutination of microorganism
+
+23
+00:02:01,870 --> 00:02:05,350
+recipitation of soluble antigens هذه كلها طبعا
+
+24
+00:02:05,350 --> 00:02:10,710
+الوظائف المفهومة activation of serum complement
+
+25
+00:02:10,710 --> 00:02:15,890
+لأنه بينشط ال complement to facilitate lysis of
+
+26
+00:02:15,890 --> 00:02:20,070
+microorganism حصلتها lysis of microorganism
+
+27
+00:02:20,070 --> 00:02:23,630
+ability to cross the placenta في بعضها بيعمل
+
+28
+00:02:23,630 --> 00:02:27,970
+crossing لل placenta و from mother to the fetus
+
+29
+00:02:30,790 --> 00:02:33,730
+الاختلاف في الـ biological activity وفي الـ
+
+30
+00:02:33,730 --> 00:02:38,410
+antibody هي
+
+31
+00:02:38,410 --> 00:02:43,590
+اللي بتساهم او بتشكلنا ال isotypic class structure
+
+32
+00:02:43,590 --> 00:02:52,250
+isotypic class structure و ال antibody molecule ما
+
+33
+00:02:52,250 --> 00:02:56,250
+بيتركز في الجامعة global infraction اللي لو عملنا
+
+34
+00:02:56,250 --> 00:03:04,420
+protein electrophoresis هنلاقيإنه أدوى ال
+
+35
+00:03:04,420 --> 00:03:08,780
+Electrophoresis اللى بيتمثل بالقاتى هذا طبعا
+
+36
+00:03:08,780 --> 00:03:13,820
+abnormal protein Electrophoresis ل myeloma patient
+
+37
+00:03:13,820 --> 00:03:18,300
+لكن عشان نعرف بس الأوضاع هذا ال album انه في كمان
+
+38
+00:03:18,300 --> 00:03:27,300
+واحدة هنا pre album spike ثم Alpha Globulin و
+
+39
+00:03:27,300 --> 00:03:33,150
+Alpha 2 Globulinبيتا جلوبيلين و جاما جلوبيلين في
+
+40
+00:03:33,150 --> 00:03:38,350
+الجاما جلوبيلين هو اللي موجود بيشكلنا ال antibody
+
+41
+00:03:38,350 --> 00:03:41,370
+ال
+
+42
+00:03:41,370 --> 00:03:47,990
+structure mainly زي ما انتوا شايفين بيمر
+
+43
+00:03:47,990 --> 00:03:57,130
+في مرحلتين مرحلة ال pre B cell receptor يعني ال
+
+44
+00:03:57,130 --> 00:04:04,490
+precursor يعني الجبل ما يتكون ال PCR و ال PCR طبعا
+
+45
+00:04:04,490 --> 00:04:10,710
+في ال Pre-B هو اللى غالبا بتكون ال ال ال Hevet
+
+46
+00:04:10,710 --> 00:04:17,890
+Chain هي عمرها ال Mu Chain و ال بعد هيك ال Hevet
+
+47
+00:04:17,890 --> 00:04:23,150
+Chain ممكن تتبدل و تصير Mu او Delta او Gamma او
+
+48
+00:04:23,150 --> 00:04:29,270
+Alpha او Y في حالة ال PCR و Structurallyطبعا في
+
+49
+00:04:29,270 --> 00:04:33,190
+مصطلح ان شاء الله هنتطلق اليه قدام اللي هو ال
+
+50
+00:04:33,190 --> 00:04:37,810
+immunoreceptor tyrosine based activation motif
+
+51
+00:04:37,810 --> 00:04:43,610
+اللي ان شاء الله هنتطلق اليه زي ما انتوا شايفين ال
+
+52
+00:04:43,610 --> 00:04:51,490
+structure ده في ال pre-b ده هو بيتكوين من lighted
+
+53
+00:04:51,490 --> 00:04:54,610
+chain و من heavy chain connected to each other by
+
+54
+00:04:54,610 --> 00:04:59,500
+disulfide bondو Lighted Chain ممكنة على سبيل
+
+55
+00:04:59,500 --> 00:05:03,080
+المثال انها نوع Delta لان سنشاهد انها ممكن تكون
+
+56
+00:05:03,080 --> 00:05:06,540
+كعبة او Delta وLeft Chain هذا زي ما انتوا شايفين
+
+57
+00:05:06,540 --> 00:05:13,200
+هي عبارة عن Mu Chain جنب ال structure هذا و هدف
+
+58
+00:05:13,200 --> 00:05:16,560
+الفيجر هذا انه نورجكوا ال Immunoglobulin Alpha
+
+59
+00:05:16,560 --> 00:05:21,140
+Immunoglobulin Beta موليكيول هذا هو جنبه و هذا هو
+
+60
+00:05:21,140 --> 00:05:26,200
+مغروز في داخل انه IntracytoplasmicDomain أو
+
+61
+00:05:26,200 --> 00:05:33,640
+Membrane أو Domain و هذا الـ Intracytoplasmic
+
+62
+00:05:33,640 --> 00:05:37,640
+portion هو المسؤول عن Cell Signaling الموليكيوم
+
+63
+00:05:37,640 --> 00:05:41,420
+طبعا كما تشوفون دونا في عندنا Antigen Binding
+
+64
+00:05:41,420 --> 00:05:45,420
+وعندنا هنيجي على Structure بشيء من التفصيل
+
+65
+00:05:45,420 --> 00:05:48,840
+Structure
+
+66
+00:05:48,840 --> 00:05:54,790
+of light and heavy chain ده همطبعا ال structure of
+
+67
+00:05:54,790 --> 00:05:59,570
+light او ال heavy chain هذي light chain وهذه heavy
+
+68
+00:05:59,570 --> 00:06:02,770
+chain connected to each other by disulfide bond هي
+
+69
+00:06:02,770 --> 00:06:06,830
+disulfide bond شوان كانت ال light مع ال heavy او
+
+70
+00:06:06,830 --> 00:06:10,670
+ال heavy مع ال heavy في disulfide bond موجودة كيف
+
+71
+00:06:10,670 --> 00:06:17,370
+تعرف عن ال structure ofبالتالي استخدموا تقاطع
+
+72
+00:06:17,370 --> 00:06:23,590
+الموليكيول الانتيبادي مقاوم للبروتيولايزيز
+
+73
+00:06:25,020 --> 00:06:29,180
+بإمكانية تقطيعه بواسطة two enzymes واحد اسمه
+
+74
+00:06:29,180 --> 00:06:32,900
+papine واحد اسمه pepsin ال papine بيقطع ال
+
+75
+00:06:32,900 --> 00:06:38,720
+antibody لتلت أجزاء توفى ب fragment واحدة FC بينما
+
+76
+00:06:38,720 --> 00:06:44,320
+ال pepsin زي ما انتوا شايفين بيقطع ال fragment ال
+
+77
+00:06:44,320 --> 00:06:48,200
+antibody immunoglobul لتثقين جزء كبير اللي هو
+
+78
+00:06:48,200 --> 00:06:56,910
+عبارة عنتوفب مع بعض و Fc prime بيسموها او Fc sub
+
+79
+00:06:56,910 --> 00:07:03,690
+fragment كمية قليلة من ال Fc portion structure
+
+80
+00:07:03,690 --> 00:07:10,470
+هذا بشكل عام لان هنجد ان شاء الله لفة فصيلته هي ال
+
+81
+00:07:10,470 --> 00:07:13,370
+heavy chain اربعة polypeptide لتكون اربعة
+
+82
+00:07:13,370 --> 00:07:20,450
+polypeptide chain تنتين heavy هذا همو تنتين light
+
+83
+00:07:20,450 --> 00:07:25,090
+هدى light و هدى light they are connected to each
+
+84
+00:07:25,090 --> 00:07:29,550
+other by what؟ by disulfide bond فى انها نوعين من
+
+85
+00:07:29,550 --> 00:07:34,390
+ال disulfide فى انترا disulfide bond و ده هي زى ما
+
+86
+00:07:34,390 --> 00:07:40,090
+انتوا شايفين و فى انتر disulfide bond اللى بتتربط
+
+87
+00:07:40,090 --> 00:07:45,790
+ال two of eachين مع بعض ال
+
+88
+00:07:47,790 --> 00:07:50,750
+Properties of the chain الـ Light تتكوّن من الـ
+
+89
+00:07:50,750 --> 00:07:57,970
+two domains VL وCL Light برمجولها بقى Light ال
+
+90
+00:07:57,970 --> 00:08:01,930
+Light برمجولها بقى L وهي تتكوّن من ال two domains
+
+91
+00:08:01,930 --> 00:08:06,590
+واحد variable واحد constant بينما ال Heavy تتكوّن
+
+92
+00:08:06,590 --> 00:08:13,170
+من اكتر من domain واحد منهم variable بيسموه VH
+
+93
+00:08:13,630 --> 00:08:19,430
+والباقي constant ففي عندنا CH واحد و CH اتنين و CH
+
+94
+00:08:19,430 --> 00:08:29,270
+تلاتة عند ال .. ال .. ال heavy chain are
+
+95
+00:08:29,270 --> 00:08:40,310
+connected يعني by region بيسموها hinge region و ان
+
+96
+00:08:40,310 --> 00:08:44,080
+شاء الله هنتطلق لوظيفتها الآناللي اريد ان تشاهدوا
+
+97
+00:08:44,080 --> 00:08:49,080
+الان ان ال VH والLH يكونوا الانتجرين بايندرينج
+
+98
+00:08:49,080 --> 00:08:55,080
+سايس والباقي يكون ال Fc بورشين في ال biological
+
+99
+00:08:55,080 --> 00:08:56,060
+activity
+
+100
+00:09:01,850 --> 00:09:06,650
+ماشي اتفقنا ان ال بيابين ده هو قسمه الى two FAB
+
+101
+00:09:06,650 --> 00:09:13,250
+FAB زائد FAB زائد FC و ال FAB fragment كان بياند
+
+102
+00:09:13,250 --> 00:09:19,770
+انتجين عادي جدا لكنها مابتعمل precipitation لأنها
+
+103
+00:09:19,770 --> 00:09:25,110
+univalent ماشي و ال FC portion اتفقنا انها هي
+
+104
+00:09:25,110 --> 00:09:30,070
+المسؤولة عن ال biological activity لو عملنا ال
+
+105
+00:09:30,070 --> 00:09:35,770
+antibodyبالـ mercaptoethanol الـ mercaptoethanol
+
+106
+00:09:35,770 --> 00:09:43,010
+هيقطع الاساس bond ويدينا four chain زي ما اتفقنا
+
+107
+00:09:43,010 --> 00:09:48,730
+two light و two heavy ال antibody بيتكون من أربع
+
+108
+00:09:48,730 --> 00:09:52,870
+polyp بتاعي two light و two heavy و طبعا they are
+
+109
+00:09:52,870 --> 00:09:56,650
+linked to each other by disulfide bond اللي كمان
+
+110
+00:09:56,650 --> 00:10:00,710
+قلنا ان ال pepsin digest the M-unoglobulin
+
+111
+00:10:03,940 --> 00:10:10,060
+والمحصلة Divalent Fragment اسمها FAB الكل 2 تتكوّن
+
+112
+00:10:10,060 --> 00:10:14,660
+من Two Fabregion مرتبطين مع بعض By Disulfide Bond
+
+113
+00:10:14,660 --> 00:10:20,240
+in addition to the Fc Subfragment اللي هي عبارة عن
+
+114
+00:10:20,240 --> 00:10:25,440
+أقل من Fragment وطبعا برمجولها في بعض الكتب بالـ
+
+115
+00:10:25,440 --> 00:10:30,140
+Fc Prime Other molecule belonging to the
+
+116
+00:10:30,140 --> 00:10:31,820
+immunoglobulin superfamily
+
+117
+00:10:35,070 --> 00:10:38,790
+Sharing with the immunoglobulin structure واحنا
+
+118
+00:10:38,790 --> 00:10:44,390
+هتترق ان شاء الله عاديهم ال lighted chain غالبا
+
+119
+00:10:44,390 --> 00:10:49,830
+بتكون يا اما كابا يا اما lambda وحسب ال structure
+
+120
+00:10:49,830 --> 00:10:53,610
+of heavy chain يعني ال heavy chain هي مسئولة عن
+
+121
+00:10:53,610 --> 00:10:58,290
+تكوين الisotypes او ال classes of immunoglobulin
+
+122
+00:10:59,690 --> 00:11:08,550
+ونجد ان الهيوتشين تختلف من واحد لتاني باختلاف
+
+123
+00:11:08,550 --> 00:11:13,510
+الانتجين وتحتوي على مواصلة الكربوهيدرات ومركزها
+
+124
+00:11:13,510 --> 00:11:19,250
+بشكل عام كربوهيدرات في منطقة الهيوتشين وتختلف أيضا
+
+125
+00:11:19,250 --> 00:11:28,810
+في صميمها ما بينها وايضا هناك اختلافاتIn
+
+126
+00:11:28,810 --> 00:11:36,590
+biological function on each isotype لإن اي one
+
+127
+00:11:36,590 --> 00:11:43,210
+antibody molecule في عندنا الهيلوجين which are
+
+128
+00:11:43,210 --> 00:11:48,210
+identical فعلى سبيل المثال في ال immunoglobulin
+
+129
+00:11:48,210 --> 00:11:55,230
+class في عندنا ال structure بيكون Kappa 2 Gamma 2
+
+130
+00:11:55,230 --> 00:12:01,510
+وLambda 2 Gamma 2TWO IDENTICAL LIGHTED CHAIN AND
+
+131
+00:12:01,510 --> 00:12:06,290
+TWO IDENTICAL HEAVY CHAIN بعض الـ Immunoglobulin
+
+132
+00:12:06,290 --> 00:12:11,670
+subclasses زي ال IGG الو subclasses
+
+133
+00:12:11,670 --> 00:12:18,330
+و IGG الو أربع subclasses سموهم immunoglobulin 1
+
+134
+00:12:18,330 --> 00:12:25,430
+IGG 1 و 2 و 3 و 4 أيضا ال immunoglobulin A الو two
+
+135
+00:12:25,430 --> 00:12:31,540
+subclasses IGA و IG2بعض المدارس التي تختلف عن
+
+136
+00:12:31,540 --> 00:12:38,380
+المدارس هي انها تختلف في رقمها ومجموعة الـ Inter
+
+137
+00:12:38,380 --> 00:12:43,180
+-Chain Disulfide Bond وبعض الإختلافات في الـ
+
+138
+00:12:43,180 --> 00:12:49,500
+Structure الـ Light Chain بتحتوي على 2 Domain
+
+139
+00:12:49,500 --> 00:12:53,040
+Globular Domain وLeft Chain بتحتوي على 4 أو 5
+
+140
+00:12:53,040 --> 00:12:54,260
+Domain
+
+141
+00:13:00,310 --> 00:13:05,190
+هيبتشين يتوحك عليها من خلال قطع قطع قطع قطع قطع
+
+142
+00:13:05,190 --> 00:13:05,670
+قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع
+
+143
+00:13:05,670 --> 00:13:06,350
+قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع
+
+144
+00:13:06,350 --> 00:13:06,810
+قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع
+
+145
+00:13:06,810 --> 00:13:07,090
+قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع
+
+146
+00:13:07,090 --> 00:13:08,110
+قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع قطع
+
+147
+00:13:21,380 --> 00:13:24,980
+اللي هو domain في الـ heavy وفي ال light is highly
+
+148
+00:13:24,980 --> 00:13:29,820
+variable في تركيبته من ناحية amino acid sequence
+
+149
+00:13:29,820 --> 00:13:35,940
+وبيختلف from one antibody to the next وبيرمزولهم
+
+150
+00:13:35,940 --> 00:13:43,500
+VL يعني variable light or VH يعني variable heavy
+
+151
+00:13:43,500 --> 00:13:50,120
+the second and subsequent domainفي الـ Heavy وفي
+
+152
+00:13:50,120 --> 00:13:55,260
+الـ Light Chain هما مستمرين برمز
+
+153
+00:13:55,260 --> 00:13:58,920
+CLCH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و
+
+154
+00:13:58,920 --> 00:14:04,320
+CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و
+
+155
+00:14:04,320 --> 00:14:06,500
+CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و
+
+156
+00:14:06,500 --> 00:14:07,700
+CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و CH1 و
+
+157
+00:14:07,700 --> 00:14:18,670
+CH1 و CH1 و CH1 وby hydrophobic interaction as
+
+158
+00:14:18,670 --> 00:14:26,850
+follows فبنلاحظ انه في عندنا VH LH يعني V heavy مع
+
+159
+00:14:26,850 --> 00:14:33,650
+light heavy و CH واحد مع ال constant تبع ال light
+
+160
+00:14:33,650 --> 00:14:37,170
+ثم بتبدأ ال constant بتاعة ال heavy بترتبط مع بعض
+
+161
+00:14:37,170 --> 00:14:42,390
+constant V2 مع constant V2 و constant V3 مع
+
+162
+00:14:42,390 --> 00:14:44,290
+constant V3
+
+163
+00:14:48,990 --> 00:14:52,530
+الـ Hedge region زي ما اتفقنا هي عبارة عن نطقة
+
+164
+00:14:52,530 --> 00:14:57,610
+unfolded بسموها region composed of short segments
+
+165
+00:14:57,610 --> 00:15:04,690
+of amino acids غالبا هي التي تفصل ما بين CH1 و CH2
+
+166
+00:15:04,690 --> 00:15:12,850
+region ومليانة بال cysteine and bromine residue و
+
+167
+00:15:12,850 --> 00:15:16,170
+ال cysteine هو المسئول عن ال formation of
+
+168
+00:15:16,170 --> 00:15:22,630
+interchain disulfide bondوالبرولين ريزيجيو بيمنع
+
+169
+00:15:22,630 --> 00:15:32,530
+اللي هو الاتفاف ال structure of heavy chain in
+
+170
+00:15:32,530 --> 00:15:39,030
+globular form بيبقى الموجود بنفس النمط ايضا من
+
+171
+00:15:39,030 --> 00:15:46,270
+صفاتها انها بتكسب ال antibody flexibility وخصوصا
+
+172
+00:15:47,060 --> 00:15:50,740
+في الـ Fab region فبالتالي بتتحرك freely ال Fab
+
+173
+00:15:50,740 --> 00:15:55,900
+region in the Y-shape وهذا بيمكنها بيمكن الطوفة
+
+174
+00:15:55,900 --> 00:16:04,300
+انهم يفتحوا و يسكروا ليتكيفوا حسب الارتباط مع two
+
+175
+00:16:04,300 --> 00:16:10,500
+Epitopes موجودين على سطح Antigen ان كانوا بعد ال
+
+176
+00:16:10,500 --> 00:16:16,210
+two Epitopes او اجراب الالـ Fabregion بتفتح و
+
+177
+00:16:16,210 --> 00:16:21,930
+بتسكر عشان تمسكلي في هدول التنتين Variable Region
+
+178
+00:16:21,930 --> 00:16:25,050
+حالة
+
+179
+00:16:25,050 --> 00:16:26,870
+بدنا نحكي عن ال Variable Region في الـ left and
+
+180
+00:16:26,870 --> 00:16:31,830
+left chain جاله بتتكامن من 110 amino acids و
+
+181
+00:16:31,830 --> 00:16:36,690
+بتحتوي على three regions بيسموهم Hypervariable
+
+182
+00:16:36,690 --> 00:16:42,070
+Region و ال Hypervariable Region هي المسئولة عن ال
+
+183
+00:16:42,070 --> 00:16:43,030
+antigen binding
+
+184
+00:16:45,950 --> 00:16:50,630
+بتكون حاجة بيسموها complementary structure to the
+
+185
+00:16:50,630 --> 00:16:55,210
+antigen epitope يعني مكمل ما احنا عارفين ان ال
+
+186
+00:16:55,210 --> 00:16:58,210
+antigen antibody reaction هو برعنة K-unlocked
+
+187
+00:16:58,210 --> 00:17:02,350
+theory يبقى واحد بده يكون ضبا والتاني مفتاح ففيه
+
+188
+00:17:02,350 --> 00:17:06,530
+complementary structure لازم يتكون عشان واحد يرتبط
+
+189
+00:17:06,530 --> 00:17:11,010
+في التاني these hypervariable regions are termed
+
+190
+00:17:11,010 --> 00:17:15,710
+complementary determining regionsو برمزولهم CDR1 و
+
+191
+00:17:15,710 --> 00:17:22,710
+CDR2 و CDR3 و الـ two-dimensional model of the
+
+192
+00:17:22,710 --> 00:17:28,310
+peptide chain are brought together in the folded
+
+193
+00:17:28,310 --> 00:17:33,310
+form of the intact antibody molecule التنين مع
+
+194
+00:17:33,310 --> 00:17:36,590
+بعيد بيكونوا ال binding sites اللي احنا بنحكي
+
+195
+00:17:36,590 --> 00:17:40,050
+عليها which is complementary تلعبتهليس two
+
+196
+00:17:40,050 --> 00:17:42,750
+-dimensional يعني واحدة من الـ heavy واحدة من ال
+
+197
+00:17:42,750 --> 00:17:47,670
+light التنتين مع بعض بكونه اللي هو folded together
+
+198
+00:17:47,670 --> 00:17:53,970
+to form the complementary portion of to the EBITO
+
+199
+00:17:53,970 --> 00:17:57,390
+variability
+
+200
+00:17:57,390 --> 00:18:02,330
+of these CDR provide diversity هي اللي بتوصف بت ..
+
+201
+00:18:02,330 --> 00:18:08,020
+بت .. بتأكد ان او بت ..بتبين لنا أو بتكون لنا
+
+202
+00:18:08,020 --> 00:18:13,320
+الاختلافات المختلفة في الشكل between antibody
+
+203
+00:18:13,320 --> 00:18:21,100
+والاختلافات هذه مطلوبة عشان ترتبط بمختلف أنواع ال
+
+204
+00:18:21,100 --> 00:18:25,380
+antigen اللي موجودة وبالتالي هي من تشكل
+
+205
+00:18:25,380 --> 00:18:30,740
+specificity of antibody لكلهم
+
+206
+00:18:31,300 --> 00:18:34,860
+كل الروابط ليوم يرتبط الـ Antigen مع الـ Antibody
+
+207
+00:18:34,860 --> 00:18:38,920
+تفقنا على أنه في روابط هتصير واحدة بتكمل التانية
+
+208
+00:18:38,920 --> 00:18:42,360
+لكن هذه الروابط هي عبارة عن weak لأنها كلها non
+
+209
+00:18:42,360 --> 00:18:47,900
+-covalent interaction وهذه
+
+210
+00:18:47,900 --> 00:18:51,900
+من القاعدة المهمة النقطة هذه اللي جاية انه من
+
+211
+00:18:51,900 --> 00:18:56,090
+الممكن انه two antibodyمع الـ two different يعني
+
+212
+00:18:56,090 --> 00:18:59,610
+لهم two different Anti-Amino Acid Sequence يكونوا
+
+213
+00:18:59,610 --> 00:19:03,830
+specific to the same Epitope طب شو اللي بيصير في
+
+214
+00:19:03,830 --> 00:19:08,070
+هذه الحالة؟ جالوا مرتبطوا بنفس الـ Antigen لكن ال
+
+215
+00:19:08,070 --> 00:19:12,010
+affinity of binding تختلف بينهم ال affinity of
+
+216
+00:19:12,010 --> 00:19:21,070
+binding تختلف بينهم كمان
+
+217
+00:19:21,070 --> 00:19:26,590
+قاعدة زي ما انتوا شايفينهي antibody واحد هو نفسه
+
+218
+00:19:26,590 --> 00:19:29,590
+ال antibody واحد بيرتبط ب antigen واحد و antigen
+
+219
+00:19:29,590 --> 00:19:37,290
+اتنين ماشي و طبعا هذا زي ما قلنا الارتباط ممكن
+
+220
+00:19:37,290 --> 00:19:46,170
+يكون في sharing of anti of ابتوب لكن ال affinity
+
+221
+00:19:46,170 --> 00:19:47,610
+of binding is different
+
+222
+00:19:52,180 --> 00:19:56,640
+الـ CDR 1 و 2 و 3 اللي هو أخذ جزء من .. عملونا
+
+223
+00:19:56,640 --> 00:20:04,440
+تحليل بالـ HPLC و وجدوا انه ال .. كل ما طلعنا لبرا
+
+224
+00:20:04,440 --> 00:20:09,420
+بال FAB في منطقة الـ FAB region كل ما اتزادت ال
+
+225
+00:20:09,420 --> 00:20:13,450
+hyper variabilityكل ما زادت ال variability of the
+
+226
+00:20:13,450 --> 00:20:17,270
+molecule ف CDR3 ال variability فيها اكتر حاجة
+
+227
+00:20:17,270 --> 00:20:23,410
+بيليها اتنين اقلها واحد اقلها واحد عشان ايه كل ما
+
+228
+00:20:23,410 --> 00:20:30,790
+طلعنا لبرا كل ما زادت ال specificity of the
+
+229
+00:20:30,790 --> 00:20:35,390
+molecule cross
+
+230
+00:20:35,390 --> 00:20:37,830
+reacting compound share antigenic determinant
+
+231
+00:20:37,830 --> 00:20:42,820
+طبيعي جدا لازم يكون فيإذا صار فيه cross reaction
+
+232
+00:20:42,820 --> 00:20:48,480
+معناته في sharing في ال Epitopes ماشي some cross
+
+233
+00:20:48,480 --> 00:20:53,720
+reacting substances are unrelated to each other
+
+234
+00:20:53,720 --> 00:21:01,200
+إلا إنه بعض المرات بيكون فيه اشتراك في one or more
+
+235
+00:21:01,200 --> 00:21:06,960
+Epitopes in common المواد
+
+236
+00:21:09,210 --> 00:21:17,290
+اللي لا تشترك طبعا بيسموها في هذه الحالة ال
+
+237
+00:21:17,290 --> 00:21:24,290
+heterophilic antigen heterophil
+
+238
+00:21:24,290 --> 00:21:27,610
+لإنها جاية من two different species يعني على سبيل
+
+239
+00:21:27,610 --> 00:21:31,250
+المثال human blood group antigen بتتفاعل مع
+
+240
+00:21:31,250 --> 00:21:35,070
+antibody ل E.coli يعني يوم يصاب الإنسان بال E.coli
+
+241
+00:21:35,510 --> 00:21:42,190
+انفكشن ويكون الجسم انتيبادي هذه الانتيبادي تتفاعل
+
+242
+00:21:42,190 --> 00:21:46,570
+مع blood group بيه انتجن ماشي في هذه الحالة
+
+243
+00:21:46,570 --> 00:21:52,810
+الانتجن of both E.coli and بيه blood group انتجن
+
+244
+00:21:52,810 --> 00:21:58,370
+are فيه similarity ماشي فيه sharing للAB2
+
+245
+00:22:00,170 --> 00:22:01,970
+وبالتالي اللهم صلى الله عليه و سلم و محمد اللهم
+
+246
+00:22:01,970 --> 00:22:02,150
+صلى الله عليه و سلم و محمد اللهم صلى الله عليه و
+
+247
+00:22:02,150 --> 00:22:03,950
+سلم و محمد اللهم صلى الله عليه و سلم و محمد اللهم
+
+248
+00:22:03,950 --> 00:22:04,550
+صلى الله عليه و سلم و محمد اللهم صلى الله عليه و
+
+249
+00:22:04,550 --> 00:22:06,470
+سلم و محمد اللهم صلى الله عليه و سلم و محمد اللهم
+
+250
+00:22:06,470 --> 00:22:08,090
+صلى الله عليه و سلم و محمد اللهم صلى الله عليه و
+
+251
+00:22:08,090 --> 00:22:10,590
+سلم و محمد اللهم صلى الله عليه و سلم و محمد اللهم
+
+252
+00:22:10,590 --> 00:22:11,070
+سلم و محمد اللهم صلى الله عليه و سلم و محمد اللهم
+
+253
+00:22:11,070 --> 00:22:15,950
+صلى الله عليه و سلم و محمد اللهم صلى الله عليه و
+
+254
+00:22:15,950 --> 00:22:22,370
+سلم و
+
+255
+00:22:22,370 --> 00:22:27,870
+محمد اللهم
+
+256
+00:22:27,870 --> 00:22:34,510
+صلىأيضاً نعرف أن هناك الاختلافات الجنية بين
+
+257
+00:22:34,510 --> 00:22:40,450
+الاندفيدوال بين الاندفيدوال يعني ال isotypes هي
+
+258
+00:22:40,450 --> 00:22:43,030
+عبارة عن الاختلافات الموجودة في داخل الإنسان
+
+259
+00:22:43,030 --> 00:22:46,670
+الallotypes هي الاختلافات الموجودة between
+
+260
+00:22:46,670 --> 00:22:51,590
+individuals of the same species يعني أن هناك
+
+261
+00:22:51,590 --> 00:22:58,250
+اختلافات بين الاندفيدوال اللي موجودة بينهمليش؟ لأن
+
+262
+00:22:58,250 --> 00:23:02,370
+الجينات اللي موجودة في كل واحد مختلفة عن الجينات
+
+263
+00:23:02,370 --> 00:23:06,790
+التانية. These are called Allotypic Variations.
+
+264
+00:23:07,790 --> 00:23:12,310
+طبعا ال Allotypic Differences at long loss usually
+
+265
+00:23:12,310 --> 00:23:16,390
+involve changes in one or two amino acids in
+
+266
+00:23:16,390 --> 00:23:20,210
+constant region.اختلافات غالبا بتكون اختلافات في
+
+267
+00:23:20,210 --> 00:23:27,130
+ال constant region تبعت ال antibody.Anatopic bind
+
+268
+00:23:27,130 --> 00:23:32,670
+the same antigen in similar way او ارتبته و ال
+
+269
+00:23:32,670 --> 00:23:35,770
+markers طبعا زى ما قلنا فيه اختلافات في الجين و
+
+270
+00:23:35,770 --> 00:23:39,310
+السبب ليش لإنه الجين بيكون بين ال polymorph فبيكون
+
+271
+00:23:39,310 --> 00:23:42,750
+فيه different قليل وبالتالي القليل تديني ايش
+
+272
+00:23:42,750 --> 00:23:46,430
+different structure لكن الاختلافات بتكون بسيطة
+
+273
+00:23:46,430 --> 00:23:51,050
+marker ل ال antibody وجدوا انه فيه في الجعمة chain
+
+274
+00:23:51,050 --> 00:23:57,460
+اللى بتدين امينoglobulin G في GMو في KM في الـ
+
+275
+00:23:57,460 --> 00:24:02,420
+Kappa Chain و في AM في الـ Alpha Chain عشان هيك في
+
+276
+00:24:02,420 --> 00:24:08,940
+عندها ساوي Classes في الـ G و الـ A Classes
+
+277
+00:24:08,940 --> 00:24:15,620
+Urban Ideas are inherited in Mendelian traits الـ
+
+278
+00:24:15,620 --> 00:24:19,780
+Idiotypes بتمثل
+
+279
+00:24:19,780 --> 00:24:24,500
+الاختلافات في الـ VL في الفبريريم و الـ VH
+
+280
+00:24:27,370 --> 00:24:33,830
+و هدولة إذا كان طبعا نقلناهم
+
+281
+00:24:33,830 --> 00:24:41,650
+من إنسان إلى إنسان يعتبروا immunogenic و يكونوا
+
+282
+00:24:41,650 --> 00:24:48,550
+immune response طبعا الاختلافات هذه موجودة between
+
+283
+00:24:48,550 --> 00:24:54,450
+different individuals of the same speciesعشان هيك
+
+284
+00:24:54,450 --> 00:24:58,410
+هذه الظاهرة ممكن يستخدموها by using anti-idiotypic
+
+285
+00:24:58,410 --> 00:25:05,830
+structure وهذا ممنع على طول ال antigen يعني اتباط
+
+286
+00:25:05,830 --> 00:25:07,030
+ال antibody بال antigen
+
+287
+00:25:11,120 --> 00:25:16,220
+هذه الاختلافات لـ Detopic determinants اللي موجودة
+
+288
+00:25:16,220 --> 00:25:20,420
+في الـ immunoglobulin ممكن يكون الأساس في التحكم
+
+289
+00:25:20,420 --> 00:25:25,700
+بال immune response modulation وهي ال structure
+
+290
+00:25:25,700 --> 00:25:31,680
+تلاتةأي في انا isotypes اختلاف كله اي اختلفت في
+
+291
+00:25:31,680 --> 00:25:37,320
+ايه؟ في ال constant region وبالتالي داني different
+
+292
+00:25:37,320 --> 00:25:43,200
+class يعني هنا في انا IGG ال constant عنده مفروض
+
+293
+00:25:43,200 --> 00:25:47,180
+انها جامعة مختلفة تماما عن ال IGA المفروض انها
+
+294
+00:25:47,180 --> 00:25:55,100
+Alpha ال Allotype في شوية اختلافات موجودة في ال
+
+295
+00:25:55,100 --> 00:25:55,880
+constant region
+
+296
+00:25:58,940 --> 00:26:04,540
+الثانية زي بعض الـ Minoglobulin GA لكن الـ
+
+297
+00:26:04,540 --> 00:26:07,320
+constant region فيها اختلافات في الاشياء وهذه
+
+298
+00:26:07,320 --> 00:26:12,540
+الاختلافات لا ترجعنياش عن وجود الاليليك forms في
+
+299
+00:26:12,540 --> 00:26:17,960
+الجين نفسه بتدينا different form of Minoglobulin
+
+300
+00:26:17,960 --> 00:26:22,340
+الاديو تاعي بالاختلاف وين؟ هذا هو في ال Fab region
+
+301
+00:26:23,460 --> 00:26:26,360
+الاختلاف بين الـ IgG وبالتالي فى عندنا different
+
+302
+00:26:26,360 --> 00:26:31,000
+specific specificity لكن زى ما قلنا لكوا انه هذا
+
+303
+00:26:31,000 --> 00:26:35,000
+لو انتقل من سن لإنسان it will be considered
+
+304
+00:26:35,000 --> 00:26:41,240
+immunogenic immunoglobulin
+
+305
+00:26:41,240 --> 00:26:45,900
+G هو اللى بنيه dominant immunoglobulin فى blood فى
+
+306
+00:26:45,900 --> 00:26:47,720
+lymph node فى lymph
+
+307
+00:26:50,550 --> 00:26:54,970
+الـ fluid و في الـ CSF البريتونيال الـ fluid يعني
+
+308
+00:26:54,970 --> 00:26:59,630
+الموجود في different types of fluid في الجسم و
+
+309
+00:26:59,630 --> 00:27:02,190
+غالبا it's distributed equally between
+
+310
+00:27:02,190 --> 00:27:05,670
+intravascular and extravascular يعني اللي في جوا و
+
+311
+00:27:05,670 --> 00:27:11,130
+برا تقريبا نفس الحاجة بيتكوّن من two gamma wave
+
+312
+00:27:11,130 --> 00:27:18,170
+chain و two lighted chain إلا إما كابا و إما
+
+313
+00:27:18,170 --> 00:27:21,990
+لامبداوقلنا في عندنا four sub classes لل
+
+314
+00:27:21,990 --> 00:27:27,470
+immunoglobulin G في واحد واثنين وتلاتة واربع واحد
+
+315
+00:27:27,470 --> 00:27:35,150
+هو اكثرهم تركيزا و IGG sub classes بتختلف بين بعض
+
+316
+00:27:35,150 --> 00:27:40,050
+بال chemical و biological properties فبنلاقي انه
+
+317
+00:27:40,050 --> 00:27:45,170
+بشكل عام they can agglutinate or clump a
+
+318
+00:27:45,170 --> 00:27:47,050
+particulate يعني انتجن
+
+319
+00:27:49,560 --> 00:27:56,720
+الـ reaction
+
+320
+00:27:56,720 --> 00:28:08,260
+غالبا مع سوليوم الانتيجين بيعمل
+
+321
+00:28:08,260 --> 00:28:14,430
+precipitate إذا كان multi-valentالانسوليبال انتيجن
+
+322
+00:28:14,430 --> 00:28:20,730
+انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن
+
+323
+00:28:20,730 --> 00:28:24,870
+انتيجن
+
+324
+00:28:24,870 --> 00:28:25,470
+انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن
+
+325
+00:28:25,470 --> 00:28:25,810
+انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن
+
+326
+00:28:25,810 --> 00:28:26,690
+انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن
+
+327
+00:28:26,690 --> 00:28:27,570
+انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن
+
+328
+00:28:27,570 --> 00:28:28,650
+انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن
+
+329
+00:28:28,650 --> 00:28:31,050
+انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن
+
+330
+00:28:31,050 --> 00:28:40,590
+انتيجن انتيجن انتيجن
+
+331
+00:28:40,590 --> 00:28:47,090
+انإذا كان الـ Antibody Multivalent و الـ Insoluble
+
+332
+00:28:47,090 --> 00:28:52,850
+على طول فجوزة Excel بتخلصنا منه من صفات ال IGG
+
+333
+00:28:52,850 --> 00:28:56,770
+نهوط Cancrosta placenta و قالوا كلهم Cancrosta
+
+334
+00:28:56,770 --> 00:29:04,970
+placenta معادة IGG2 وهذا طبعا بشكل اللي هو
+
+335
+00:29:04,970 --> 00:29:08,190
+Transferring
+
+336
+00:29:08,190 --> 00:29:14,550
+immunity from mother to fetusالترانسفير البلاسنتل
+
+337
+00:29:14,550 --> 00:29:20,290
+يتم إعادته من وجود مصادر مصادر مصادر مصادر مصادر
+
+338
+00:29:20,290 --> 00:29:20,430
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+339
+00:29:20,430 --> 00:29:23,450
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+340
+00:29:23,450 --> 00:29:24,130
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+341
+00:29:24,130 --> 00:29:25,150
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+342
+00:29:25,150 --> 00:29:27,150
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+343
+00:29:27,150 --> 00:29:35,270
+مصادر مصادر مصادر مصادر مصادر
+
+344
+00:29:35,270 --> 00:29:38,230
+مص
+
+345
+00:29:40,190 --> 00:29:48,290
+في الشهر التالت أو الرابع من الحمل فيه زيادة متردخ
+
+346
+00:29:48,290 --> 00:29:56,210
+في تركيز ال IGG اللي جاي من الأم عند ال baby شهر
+
+347
+00:29:56,210 --> 00:30:00,070
+الخامس من ال emergency ببدأ ال fetus to look after
+
+348
+00:30:00,070 --> 00:30:08,250
+himself وبالتالي ببدأ يكوّن IgM وشوية IgA
+
+349
+00:30:11,990 --> 00:30:15,830
+3 او 4 أشهر بعد الولادة بعد الولادة بتالتة اربع
+
+350
+00:30:15,830 --> 00:30:21,050
+شهور بيبدأ ال infants to synthesize its own IgG
+
+351
+00:30:21,050 --> 00:30:27,390
+ويتهادة طبعا بيكون مسحوق بقلة drop in the
+
+352
+00:30:27,390 --> 00:30:32,890
+concentration of maternal IgG absorption of
+
+353
+00:30:32,890 --> 00:30:38,750
+maternal IgG موجود في الclostrum الclostrum of
+
+354
+00:30:38,750 --> 00:30:44,870
+nursing mothers ماشيوطبعا اللي موجود في ال cluster
+
+355
+00:30:44,870 --> 00:30:52,130
+ممكن يرتبط بال FCRN Protection Receptor اللي موجود
+
+356
+00:30:52,130 --> 00:30:54,610
+على ال intestinal tissue of the neonate يعني
+
+357
+00:30:54,610 --> 00:31:01,270
+بيمتصوا ال baby الحليب اللي بياخده من الأم في IGG
+
+358
+00:31:01,270 --> 00:31:05,310
+لما يصل أمعاء ال baby أو ال neonate على طول
+
+359
+00:31:05,310 --> 00:31:09,670
+بيمتصوا من خلال وجود ال receptor FCRN اللي موجود
+
+360
+00:31:09,670 --> 00:31:16,550
+على ال intestinal tissueسفة أخرى من صفات ال IGG
+
+361
+00:31:16,550 --> 00:31:23,870
+وهي ال optionization وهذه مهمة جدا لتسهيل عملية ال
+
+362
+00:31:23,870 --> 00:31:28,230
+phagocytosis وإلا كيف تتعرف ال phagocytic cell على
+
+363
+00:31:28,230 --> 00:31:33,990
+ال antigen من خلال تعليمه by antibody mostly ال
+
+364
+00:31:33,990 --> 00:31:36,570
+IGG has this ability
+
+365
+00:31:42,170 --> 00:31:45,390
+Antibody-dependent cell-mediated cytotoxicity
+
+366
+00:31:45,390 --> 00:31:50,810
+بتعتمد على ان الـ Fabregens of IgG بترتبط
+
+367
+00:31:50,810 --> 00:31:55,810
+بالأنتجين بضال فالتنين الـ Fc Portion على الـ Fc
+
+368
+00:31:55,810 --> 00:32:00,330
+Portion وجدوا اليه ريسبتور على سطح كل الفاجوسيتك
+
+369
+00:32:00,330 --> 00:32:07,250
+سيل and أنكي سيل عشان هي كل الفاجوسيتك سيل تتعرف
+
+370
+00:32:07,250 --> 00:32:10,830
+على الانتجين بهذه الخاصية بالاضافة إلى الـ
+
+371
+00:32:10,830 --> 00:32:19,220
+Opsinizerأو كيفية
+
+372
+00:32:19,220 --> 00:32:27,900
+التعرف على الانتبادي دي بندنالـ Fabregion و IGG
+
+373
+00:32:27,900 --> 00:32:31,420
+بتمسك في الـ Antigen فبتضل فعلة مين اللي هو الـ FC
+
+374
+00:32:31,420 --> 00:32:34,900
+portion هذا اللي هو الـ Receptor على سطح الفاجوس
+
+375
+00:32:34,900 --> 00:32:39,160
+اللي تكسبه اللي بعد مرة طبعا ال killer cell تبدأ
+
+376
+00:32:39,160 --> 00:32:46,580
+تقتل ال target cell من خلال إفراز certain granules
+
+377
+00:32:46,580 --> 00:32:50,980
+عليها activation of complementby IGG complement
+
+378
+00:32:50,980 --> 00:32:57,320
+activation أيضا بيؤدي الى ال direct license of the
+
+379
+00:32:57,320 --> 00:33:00,980
+invading organism برضه بتتم من خلال ال
+
+380
+00:33:00,980 --> 00:33:07,200
+optionization يعني ايه؟ بتتم عملية ايه؟ اللي هو ال
+
+381
+00:33:07,200 --> 00:33:12,340
+direct killing by activation of complement
+
+382
+00:33:12,340 --> 00:33:15,930
+neutralization of toxinطبعا بيصير فيه Antigen
+
+383
+00:33:15,930 --> 00:33:19,370
+Antibody reaction blocking للانتجن و بيصير للتكسين
+
+384
+00:33:19,370 --> 00:33:23,330
+و بيصير فيه بيصير هذا هو immunoglobulin بلقس the
+
+385
+00:33:23,330 --> 00:33:28,870
+active site of various toxins زي التتاناس زي ال
+
+386
+00:33:28,870 --> 00:33:33,450
+portulism portulanas
+
+387
+00:33:33,450 --> 00:33:38,910
+و ال passive immunization is used immobilization
+
+388
+00:33:38,910 --> 00:33:41,710
+of بكتيريا زي تريبانيماباليديام
+
+389
+00:33:46,660 --> 00:33:51,840
+immobilization neutralization of virus IgG is an
+
+390
+00:33:51,840 --> 00:33:56,260
+efficient virus neutralizing antibody inhibition
+
+391
+00:33:56,260 --> 00:34:01,500
+of viral attachment to the target cell وطبعا بيصير
+
+392
+00:34:01,500 --> 00:34:07,160
+فيه inhibition لل penetration of virus وطبعا
+
+393
+00:34:07,160 --> 00:34:11,300
+زي ما انتوا شايفين الصورةهي الفاجوسيتك سيل
+
+394
+00:34:11,300 --> 00:34:16,280
+الهارسيبتور لل Fc portion هي ال Fc portion شايفين
+
+395
+00:34:16,280 --> 00:34:21,920
+ماسكة ال antibody من ناعت ال Fc portion طبعا ال Fc
+
+396
+00:34:21,920 --> 00:34:28,320
+portion طبعا هي زي ما انتوا شايفين زي
+
+397
+00:34:28,320 --> 00:34:29,860
+ما انتوا شايفين
+
+398
+00:34:32,840 --> 00:34:39,380
+ان الانتجين ملعق بالانتيبادي اللى فالت منه مين ال
+
+399
+00:34:39,380 --> 00:34:43,000
+Fc Portion ال Fc Portion ده اللى اللى ريسبترا ده
+
+400
+00:34:43,000 --> 00:34:50,840
+هو عبارة عن انتيبادي ده ممسك بال Fc اللى فالت وهي
+
+401
+00:34:50,840 --> 00:34:56,080
+ممسك وبالتالي بيعملش phagocytosis بتم عمليتش ال
+
+402
+00:34:56,080 --> 00:34:57,020
+phagocytosis
+
+403
+00:34:59,860 --> 00:35:03,400
+الـ اهدى طبعا ال important differences among human
+
+404
+00:35:03,400 --> 00:35:09,700
+IGG classes زى ما تلاحظى ال IGG 1 التركيز تبعه
+
+405
+00:35:09,700 --> 00:35:18,220
+اكتر واحد 70% بيالى IGG 2 بيالى 3 بيالى 4 ال half
+
+406
+00:35:18,220 --> 00:35:27,780
+life كلهم 23 يوم بعد IGG 3 complement binding ال
+
+407
+00:35:28,270 --> 00:35:32,150
+اللي بيعمل complement activation هو IGG3 أربعة
+
+408
+00:35:32,150 --> 00:35:37,910
+بيعملش واحد واتنين يعني ال placental percentage
+
+409
+00:35:37,910 --> 00:35:42,730
+كلهم بيعملوا crossing لل placenta معادة IGG2 وال
+
+410
+00:35:42,730 --> 00:35:49,130
+binding to monocytes IGG1 و 3 أكتر اتنين بيعملوا
+
+411
+00:35:49,130 --> 00:35:51,370
+ارتباط بال monocytes
+
+412
+00:35:54,890 --> 00:35:58,470
+الـ IgM هو أول أنتباط يطلع يوم ما يكون فيه
+
+413
+00:35:58,470 --> 00:36:05,250
+Infection ووجوده Indicate انه فيه Recent Infection
+
+414
+00:36:05,250 --> 00:36:10,770
+وهو عبارة عن Pentameric Molecule ال units are
+
+415
+00:36:10,770 --> 00:36:15,950
+joined together Pentameric خماسي يعني وكل unit
+
+416
+00:36:15,950 --> 00:36:18,010
+عبارة عن
+
+417
+00:36:22,480 --> 00:36:27,720
+مينو جلوبي ال structure يعني زي ال IGG ال
+
+418
+00:36:27,720 --> 00:36:33,300
+structure لحاله وبالتالي بيكون عندنا خمسة
+
+419
+00:36:33,300 --> 00:36:35,680
+different structure كل واحد منهم بيسموه unit
+
+420
+00:36:35,680 --> 00:36:39,580
+الخمسة بيجتمعوا بيرتبطوا مع بعض من خلال SS bond
+
+421
+00:36:39,580 --> 00:36:42,700
+بيرتبطوا
+
+422
+00:36:42,700 --> 00:36:48,180
+من ناحية ال FC portion و بيكونوا ال J chain
+
+423
+00:36:50,720 --> 00:36:57,260
+بتصنع أيضًا في الـ B-Oriblasma Cell الـ IgM أيضًا
+
+424
+00:36:57,260 --> 00:37:02,060
+موجود Intramuscular وموجود على سطح الـ B
+
+425
+00:37:02,060 --> 00:37:09,890
+-Lymphocyte وهو IGDبيكونوا ال PCR اللي هيرتبط
+
+426
+00:37:09,890 --> 00:37:15,190
+بالانتجن انتجن specific PCR ال IGM من صفاته انه
+
+427
+00:37:15,190 --> 00:37:17,930
+excellent complement fixing بنشط ال complement
+
+428
+00:37:17,930 --> 00:37:24,690
+بنجاح و ايضا efficient agglutinating antibody و
+
+429
+00:37:24,690 --> 00:37:28,150
+بيكون ال ISO hemagglutinin و ال ISO ال
+
+430
+00:37:28,150 --> 00:37:31,650
+hemagglutinin هم عبارة عن naturally occurring IGM
+
+431
+00:37:31,650 --> 00:37:37,990
+antibody موجودينagainst RBCs antigen يعني ال A B O
+
+432
+00:37:37,990 --> 00:37:43,160
+antigenلكن المجلد المولى أن الـ IgM اللي هو الـ
+
+433
+00:37:43,160 --> 00:37:46,820
+Isohemoglutin هدولة They cannot cross the placenta
+
+434
+00:37:46,820 --> 00:37:49,660
+وبالتالي ما بيعملوا incompatibility بين ال mother
+
+435
+00:37:49,660 --> 00:37:55,320
+و بين إيش و بين ال fetus إلا أن بعض البكتيريا اللي
+
+436
+00:37:55,320 --> 00:37:57,740
+موجودة في ال gastrointestinal أو ال respiratory
+
+437
+00:37:57,740 --> 00:38:03,180
+tract بيلها بعض ال determinants اللي بتشبه ال EBO
+
+438
+00:38:03,180 --> 00:38:07,920
+blood group IgA
+
+439
+00:38:08,860 --> 00:38:11,440
+هو الـ major antibody موجود في الـ external
+
+440
+00:38:11,440 --> 00:38:18,720
+secretion و such as saliva, mucus, sweet, gastric
+
+441
+00:38:18,720 --> 00:38:24,200
+fluid and tears و ال major antibody found in
+
+442
+00:38:24,200 --> 00:38:30,840
+clostrum of milk يعني في حليب اللبع للأم and it
+
+443
+00:38:30,840 --> 00:38:35,140
+protects intestinal tract of unit against pathogen
+
+444
+00:38:36,080 --> 00:38:40,160
+During the first week after birth وهو حامل حمالة
+
+445
+00:38:40,160 --> 00:38:45,440
+الـ Intestinal tract of Neonate Within mucous
+
+446
+00:38:45,440 --> 00:38:52,020
+secretion الـ IgA موجود على شكل دايمر مرتبط بـ J
+
+447
+00:38:52,020 --> 00:38:59,840
+Chain زي الـ J الموجودة فيه في IgM لكن هنا دايمريك
+
+448
+00:38:59,840 --> 00:39:01,060
+موليكول مش Pentameric
+
+449
+00:39:06,920 --> 00:39:16,080
+وخط سير ال IGA عندما يتكوّن في ال tissue ويخرج من
+
+450
+00:39:16,080 --> 00:39:22,500
+ال tissue على نيوكاس
+
+451
+00:39:22,500 --> 00:39:29,350
+مبرين يمر في الcellsهو مرتبط بشيء يسمى Poly
+
+452
+00:39:29,350 --> 00:39:32,850
+Immunoglobulin Receptor موجود على الـ Basal
+
+453
+00:39:32,850 --> 00:39:36,610
+Membrane of Adjacent Epithelial Cell وهذا الـ
+
+454
+00:39:36,610 --> 00:39:42,670
+Receptor بأهله أنه يخترق الـ Epithelial Cell عشان
+
+455
+00:39:42,670 --> 00:39:46,270
+يطلع Extra Cellularي في الـ Extra Cellular Fluid
+
+456
+00:39:46,270 --> 00:39:52,770
+اللي موجودة في الـ Gut أو البرونكاي وعمليةووجوده
+
+457
+00:39:52,770 --> 00:39:57,170
+أيضًا بتتسهّل
+
+458
+00:39:57,170 --> 00:40:04,090
+بوجود By enzymatic cleavage يوم يطلع من الـ
+
+459
+00:40:04,090 --> 00:40:06,450
+epithelial cell على الـ extra cellular fluid
+
+460
+00:40:06,450 --> 00:40:11,030
+بتنقطع هذه الـ poly immunoglobulin receptor لكنها
+
+461
+00:40:11,030 --> 00:40:15,530
+بتترك وراها جزء صغير بسموه secretory component
+
+462
+00:40:15,530 --> 00:40:20,190
+بيبقى مرتبط بالـ FC portion of the immunoglobulin
+
+463
+00:40:20,190 --> 00:40:20,750
+domain
+
+464
+00:40:23,640 --> 00:40:27,480
+الجزء السيكراتوري يمكن أن يساعد في حماية
+
+465
+00:40:27,480 --> 00:40:30,500
+الـDimeric Immunoglobulin-A من التكثير
+
+466
+00:40:30,500 --> 00:40:36,480
+البروتيوليتيكي، يعني التكثير.الجزء السيكراتوري
+
+467
+00:40:36,480 --> 00:40:39,240
+يمكن أن يساعد في حماية الـRespiratory and
+
+468
+00:40:39,240 --> 00:40:43,100
+gastrointestinal tract من التأثير، وهو ممكن يعمل
+
+469
+00:40:43,100 --> 00:40:48,280
+انهيبش لأي أنهيبش لجسم الإباثيليا.هو أيضًا ممكن أن
+
+470
+00:40:48,280 --> 00:40:50,840
+يعمل انهيبش لجسم الإباثيليا.هو أيضًا ممكن أن يعمل
+
+471
+00:40:50,840 --> 00:40:51,360
+انهيبش لجسم الإباثيليا.هو أيضًا ممكن أن يعمل
+
+472
+00:40:51,360 --> 00:40:56,300
+انهيبش لجسم الإباثيليا.في وجود الإيزوزاين الـ IgA
+
+473
+00:40:56,300 --> 00:40:59,920
+أيضًا من صفاته أنه يحتوي على الـ Antiviral and
+
+474
+00:40:59,920 --> 00:41:06,640
+Efficient Agglutinating Antibody وهذا هي الرحلة زي
+
+475
+00:41:06,640 --> 00:41:13,200
+ما قلنا بلازما سيل بتصنعه وفتشه بيصير as a
+
+476
+00:41:13,200 --> 00:41:16,780
+diametric molecule طبعًا عشان ينتقل إلى الـ
+
+477
+00:41:16,780 --> 00:41:21,420
+Extracellularبيروح و هو مرتبط بـ Receptor على سطح
+
+478
+00:41:21,420 --> 00:41:25,730
+الـ Adjacent Epithelial cellsو بيسمو هذا receptor
+
+479
+00:41:25,730 --> 00:41:29,330
+polyminoglobulin receptor فبيخش على شكل physical
+
+480
+00:41:29,330 --> 00:41:33,350
+في ال epithelial cells و في داخل ال physical بيتم
+
+481
+00:41:33,350 --> 00:41:38,550
+عملية تقطيعه و لما بتقطع بطلع طبعا by enzymatic
+
+482
+00:41:38,550 --> 00:41:43,790
+action بطلع extracellularly عملية التقطيع مطلوبة
+
+483
+00:41:43,790 --> 00:41:47,970
+لأنه big molecule في هذه الحالة فبدنا نزغره و بطلع
+
+484
+00:41:47,970 --> 00:41:51,310
+extracellularly لكن بيبقى
+
+485
+00:41:55,650 --> 00:42:01,330
+مرتبط بالـ Fc Portion of IgA Diameter بيسموها الـ
+
+486
+00:42:01,330 --> 00:42:04,550
+Secretory Component هي اللي بتحافظ على الموليكيوم
+
+487
+00:42:04,550 --> 00:42:10,170
+من البروتيولايسيز IGD
+
+488
+00:42:10,170 --> 00:42:13,830
+موجود
+
+489
+00:42:13,830 --> 00:42:20,080
+على سطح الـ P-Lymphocyte هو IGMو it functioned as
+
+490
+00:42:20,080 --> 00:42:26,120
+antigen receptor specific PCR اللي بيكون ان ال IGD
+
+491
+00:42:26,120 --> 00:42:29,360
+correlate with the elimination of B cell with the
+
+492
+00:42:29,360 --> 00:42:37,180
+capacity to generate self-reactive antibody إيش
+
+493
+00:42:37,180 --> 00:42:44,680
+يعني؟ يعني هو من يمنعأو يساعد في التخلص من الـ B
+
+494
+00:42:44,680 --> 00:42:49,220
+-Lymphocytes إذا تحولت إلى الـ Self-Reactive إذا
+
+495
+00:42:49,220 --> 00:42:59,760
+أنتجت لنا Self-Reactive Antibody IGE طبعا بيسموه
+
+496
+00:42:59,760 --> 00:43:05,620
+Reagenic Antibody وطبعا الـ FC Portion تبعته لها
+
+497
+00:43:05,620 --> 00:43:12,290
+ريسبتر على المستل والبيزوفيلولمّا يرتبط بالرسيبتور
+
+498
+00:43:12,290 --> 00:43:18,530
+تبعه برتبط من خلال ال fab region وفي
+
+499
+00:43:18,530 --> 00:43:22,750
+هذه الحالة بيبقى الفالة ال Fc portion اللي لما
+
+500
+00:43:22,750 --> 00:43:27,450
+يحصل cross linking بال antigen بيصير الخلية هذه
+
+501
+00:43:27,450 --> 00:43:33,470
+activated وبتبدأ تطلع لناتحتوي على أكتر من 24
+
+502
+00:43:33,470 --> 00:43:37,690
+أشكال مختلفة كيميائية أشهرها الهيستامين والهيبارين
+
+503
+00:43:37,690 --> 00:43:42,210
+واليوكترين وهذا يشغّل بالفعل عملية عملية عملية
+
+504
+00:43:42,210 --> 00:43:42,230
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+505
+00:43:42,230 --> 00:43:42,890
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+506
+00:43:42,890 --> 00:43:44,510
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+507
+00:43:44,510 --> 00:43:46,530
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+508
+00:43:46,530 --> 00:43:48,030
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+509
+00:43:48,030 --> 00:43:59,450
+عملية عملية عملية عملية
+
+510
+00:43:59,450 --> 00:44:05,930
+عماشي يوم يرتبط بالانتيجين بس الشرط الأساسي لتنشيط
+
+511
+00:44:05,930 --> 00:44:09,670
+الخلية ان يبقى هناك cross linking two adjacent
+
+512
+00:44:09,670 --> 00:44:13,930
+antibodies combine to the antigen وبالتالي بيبقى
+
+513
+00:44:13,930 --> 00:44:19,370
+هناك activation وdegranulation للخلية وطبعا بيطلع
+
+514
+00:44:19,370 --> 00:44:25,510
+زي ما قلتلكوا الهستامين والهيبرين واليوكترين
+
+515
+00:44:25,510 --> 00:44:29,210
+بيسموه ال receptor FCY
+
+516
+00:44:33,620 --> 00:44:38,980
+وهذه طبعا اللى هى جدول بيبين لى different chemical
+
+517
+00:44:38,980 --> 00:44:43,180
+and physical properties of immunoglobulins
+
+518
+00:44:43,180 --> 00:44:50,340
+المختلفة اللى سميناهم isotopes هو هى ال structure
+
+519
+00:44:50,340 --> 00:44:54,000
+of different isotypes اللى موجودة فى الجسم
+
+520
+00:44:57,520 --> 00:45:02,620
+وهي ال figure اللى قولنا كيف بيصير فيه protection
+
+521
+00:45:02,620 --> 00:45:11,920
+لل immunoglobulin IGG في ال intestinal mucosa ده
+
+522
+00:45:11,920 --> 00:45:19,160
+هو بيطلع ال IGG بياخده ال antigen في ال FCRP اللى
+
+523
+00:45:19,160 --> 00:45:24,540
+هو protection لل FCRP برتبط بال antibody ده هو ال
+
+524
+00:45:24,540 --> 00:45:27,670
+antibody اللى ماسك antigenطبعاً بيخش على شكل
+
+525
+00:45:27,670 --> 00:45:31,950
+physical بعد ذلك بيصير في dissociation للانتيجن و
+
+526
+00:45:31,950 --> 00:45:36,730
+بيظل ال antibody مرتبط بال FCRP اللي بيطلع على ال
+
+527
+00:45:36,730 --> 00:45:44,830
+cell membrane و بيرتبط ان بيدور على يعني بيحل من
+
+528
+00:45:44,830 --> 00:45:49,310
+ال receptor في وجود neutral pH طبعا ال antigen
+
+529
+00:45:49,310 --> 00:45:53,950
+بيظل في ال physical بعد ذلك ال lysozyme بيخشواهو
+
+530
+00:45:53,950 --> 00:45:56,690
+يخلصنا من الانتجن من الانتجن الانتجن الانتجن
+
+531
+00:45:56,690 --> 00:46:03,150
+الانتجن الانتجن الانتجن الانتجن الانتجن الانتجن
+
+532
+00:46:03,150 --> 00:46:05,110
+الانتجن الانتجن الانتجن الانتجن الانتجن الانتجن
+
+533
+00:46:05,110 --> 00:46:06,210
+الانتجن الانتجن الانتجن الانتجن الانتجن الانتجن
+
+534
+00:46:06,210 --> 00:46:08,150
+الانتجن الانتجن الانتجن الانتجن الانتجن الانتجن
+
+535
+00:46:08,150 --> 00:46:11,650
+الانتجن الانتجن الانتجن الانتجن الانتجن الانتجن
+
+536
+00:46:11,650 --> 00:46:20,470
+الانتجن الانتجن الانتجن
+
+537
+00:46:24,680 --> 00:46:28,640
+بسم الله الرحمن الرحيم استكملا لمحاضرة ال antibody
+
+538
+00:46:28,640 --> 00:46:32,800
+structure and function وصلنا ل ال kinetics of
+
+539
+00:46:32,800 --> 00:46:40,160
+antibody response after immunization وزي ما
+
+540
+00:46:40,160 --> 00:46:42,920
+تشايفين في ال figure في انها primary immune
+
+541
+00:46:42,920 --> 00:46:46,740
+response و في انها secondary immune response زي ما
+
+542
+00:46:46,740 --> 00:46:49,400
+تشايفين في ال primary immune response في اكتر من
+
+543
+00:46:49,400 --> 00:46:53,290
+phase بتمر فيهابمر فيها ال primary immune response
+
+544
+00:46:53,290 --> 00:46:56,430
+خلينا نتطلق إلى هذه ال phases زي ما انتوا شايفين
+
+545
+00:46:56,430 --> 00:47:00,590
+في عندنا اللي
+
+546
+00:47:00,590 --> 00:47:05,850
+هو ال latent exponential steady and declining
+
+547
+00:47:05,850 --> 00:47:13,570
+ونشوفهم طيب هذه ال primary phase بينقسم
+
+548
+00:47:13,570 --> 00:47:19,390
+إلى عدة phases أولها ال lateو ال latent هي عبارة
+
+549
+00:47:19,390 --> 00:47:25,190
+عن ال lag phase الفترة المطلوبة for B and T cell
+
+550
+00:47:25,190 --> 00:47:28,250
+to make contact وصلها proliferation and
+
+551
+00:47:28,250 --> 00:47:30,890
+differentiation make contact و ال antigen طبعا
+
+552
+00:47:30,890 --> 00:47:34,590
+وصلها proliferation and differentiation غالبا هذه
+
+553
+00:47:34,590 --> 00:47:41,230
+الفترة بتكون من one to two weeksالفز التاني
+
+554
+00:47:41,230 --> 00:47:43,830
+exponential phase وطبعا في هذا ال phase بيصير فيه
+
+555
+00:47:43,830 --> 00:47:47,570
+زيادة من ايه اسمه لل antibody concentration in
+
+556
+00:47:47,570 --> 00:47:51,610
+serum الفز التالت اللي هو steady phase وهنا بيصير
+
+557
+00:47:51,610 --> 00:47:55,630
+فيه balance في ال production and degradation واخر
+
+558
+00:47:55,630 --> 00:47:59,170
+phase هو declining phase بيبدأ ال immunoglobulin
+
+559
+00:47:59,170 --> 00:48:03,070
+to shutdown فال antibody level and structure بيصير
+
+560
+00:48:03,070 --> 00:48:08,290
+له declining rapidly اول antibody بيطلع هو ال IgM
+
+561
+00:48:08,910 --> 00:48:13,810
+وإذا كان ال IGG بدو يطلع فال IGG بيكون مصاحب زيادة
+
+562
+00:48:13,810 --> 00:48:19,270
+ال IGG بتكون مصاحبها قلة في ال production of IGF
+
+563
+00:48:19,270 --> 00:48:22,710
+في secondary immune response طبعا أثناء ال primary
+
+564
+00:48:22,710 --> 00:48:29,110
+immune response تكون ال pool from long lived
+
+565
+00:48:29,110 --> 00:48:34,070
+memory cell تكون pool of memory cell and this
+
+566
+00:48:34,070 --> 00:48:37,900
+memory cellعندها القدرة to mount a secondary
+
+567
+00:48:37,900 --> 00:48:43,300
+response of the same antigen في secondary or
+
+568
+00:48:43,300 --> 00:48:47,240
+memory response بيسموه بعد مرات anamnestic
+
+569
+00:48:47,240 --> 00:48:53,420
+response بيصير فيه طبعا apparent response to the
+
+570
+00:48:53,420 --> 00:49:01,900
+antigenو غالبا بتتم في هذا ال response اللي بيكون
+
+571
+00:49:01,900 --> 00:49:06,580
+ال lag phase is shorter و ال antibody اللي بينتج
+
+572
+00:49:06,580 --> 00:49:15,440
+بيكون أكتر و it lasts longer بمعنى بتول for month
+
+573
+00:49:15,440 --> 00:49:20,700
+or years ال
+
+574
+00:49:20,700 --> 00:49:22,900
+IgG antibody
+
+575
+00:49:26,730 --> 00:49:32,930
+بظهر بسرعة وتركيز أعلى من الـ IgM ويمكن أن يطلع
+
+576
+00:49:32,930 --> 00:49:36,250
+IgA أو IgE وبيسمو هذه الظاهرة Class-Switching
+
+577
+00:49:36,250 --> 00:49:41,090
+Phenomena بس كل الـ Antibody اللي بتطلع عبارة عن
+
+578
+00:49:41,090 --> 00:49:46,070
+has the same specificity as IgM اللي طلع بصير في
+
+579
+00:49:46,070 --> 00:49:48,650
+affinity of maturation في ال class-switching
+
+580
+00:49:48,650 --> 00:49:51,830
+وبالتالي قدرة ال antibody اللي بيطلع على الارتباط
+
+581
+00:49:51,830 --> 00:49:56,920
+بالانتجن بتكون أعلىو Secondary immune response
+
+582
+00:49:56,920 --> 00:50:03,820
+بيمثل لنا ظاهرة ال repeated immunization بمعنى
+
+583
+00:50:03,820 --> 00:50:08,480
+with attenuated طبعا justified هو برر لنا موضوع
+
+584
+00:50:08,480 --> 00:50:11,980
+اللي هو repeated immunization with attenuated
+
+585
+00:50:11,980 --> 00:50:16,340
+inactivated pathogen to induce an immune response
+
+586
+00:50:17,310 --> 00:50:20,670
+Immunoglobulin superfamily في عائلة كلها هذه
+
+587
+00:50:20,670 --> 00:50:24,310
+العائلة كلها تشترك في ال structure of
+
+588
+00:50:24,310 --> 00:50:28,670
+immunoglobulin اللي هو عبارة عن Y-shaped غالبا أو
+
+589
+00:50:28,670 --> 00:50:34,550
+وجود ال domain في ال structure فهذه العائلة هي
+
+590
+00:50:34,550 --> 00:50:37,570
+عبارة عن immunoglobulin باخد ال Y-shapeالـ
+
+591
+00:50:37,570 --> 00:50:41,730
+Structure اللى جنبه اللى هو ال molecule اللى جنبه
+
+592
+00:50:41,730 --> 00:50:45,510
+اللى هو immunoglobulin Alpha, Beta, تيرو دايمر أي
+
+593
+00:50:45,510 --> 00:50:49,490
+ماخد نفس تقريبا ال structure ثم ال T cell receptor
+
+594
+00:50:49,490 --> 00:50:59,070
+و ال CD3 CD3 عبارة عن برضه structure بيكون جنب ال
+
+595
+00:50:59,070 --> 00:51:07,420
+PCR و immunoglobulin Alpha, Betaوبيساعد أيضًا في
+
+596
+00:51:07,420 --> 00:51:11,220
+الـ Cell Signaling ثم Class I و Class II MHC
+
+597
+00:51:11,220 --> 00:51:15,000
+موليكيول ثم Poly-Immunoglobulin Receptor اللي قلنا
+
+598
+00:51:15,000 --> 00:51:21,660
+IGA برتبط فيه عشان تفسيلتيت اللي هو extravasation
+
+599
+00:51:21,660 --> 00:51:27,080
+to the extracellular fluid ال
+
+600
+00:51:27,080 --> 00:51:30,360
+.. these molecules زي ما قلنا sharing the same
+
+601
+00:51:30,360 --> 00:51:35,880
+structure immunoglobulin 4-domainو طبعا هذا دليل
+
+602
+00:51:35,880 --> 00:51:40,900
+على ان كلهم طالعين من نفس الجينات من جينات في نفس
+
+603
+00:51:40,900 --> 00:51:46,180
+المنطقة sorry اللي هي primordial gene عملية ال
+
+604
+00:51:46,180 --> 00:51:50,190
+foldingأو الـ Loop Formation و تكوين الـ Domain
+
+605
+00:51:50,190 --> 00:51:55,450
+سببه اللي هو الـ Intra-Chain Disulfide Bond و اللي
+
+606
+00:51:55,450 --> 00:51:59,230
+بيشكل حوالي 110 Amino Acids و هذه الـ Domains
+
+607
+00:51:59,230 --> 00:52:03,810
+غالبا هي اللتي تمكن من الارتباط بالـ Cell Surface
+
+608
+00:52:03,810 --> 00:52:07,070
+Molecule زي CD4 على الـ T-Helper Cell و أماتشي
+
+609
+00:52:07,070 --> 00:52:10,250
+Class II Molecule على الـ Antigen Presenting Cell
+
+610
+00:52:10,250 --> 00:52:13,430
+الموضوع
+
+611
+00:52:13,430 --> 00:52:15,130
+التاني اللي بدأنا نحكي فيه Related to
+
+612
+00:52:15,130 --> 00:52:19,040
+Immunoglobulinstructure and function هو ال
+
+613
+00:52:19,040 --> 00:52:21,940
+hybridoma technique و ال monoclonal antibody
+
+614
+00:52:21,940 --> 00:52:27,200
+formation طبعا زي ما انتوا شايفين التكنيك ببساطة و
+
+615
+00:52:27,200 --> 00:52:31,820
+باختصار احنا كل اللي بناخده هو عبارة عن spleen
+
+616
+00:52:31,820 --> 00:52:40,980
+cell mostly B lymphocytes من ال spleen المنفعر
+
+617
+00:52:40,980 --> 00:52:46,570
+عرضنا ل antigenيعني الـ B lymphocyte already تعرضت
+
+618
+00:52:46,570 --> 00:52:54,530
+ل antigen ماشي و بنجيب myeloma cell و ال myeloma
+
+619
+00:52:54,530 --> 00:53:05,940
+cell بتكون يعني مهجنة جينياأو باستخدام الـ Genetic
+
+620
+00:53:05,940 --> 00:53:09,840
+Engineering بيشيلوا منها ال enzyme Ibogazine
+
+621
+00:53:09,840 --> 00:53:14,460
+Phosphoribosyltransferase enzyme بينشأ الهيو
+
+622
+00:53:14,460 --> 00:53:18,620
+نيجاتيف و بيجيبوا التوسط طبعا Myeloma cell يعني B
+
+623
+00:53:18,620 --> 00:53:24,380
+lymphocyte لكنها cancer of B lymphocytes هذه
+
+624
+00:53:24,380 --> 00:53:27,980
+الخلية طبعا شرط انها تكون غير قادرة على إنتاج
+
+625
+00:53:27,980 --> 00:53:30,080
+immunoglobulin
+
+626
+00:53:36,490 --> 00:53:41,670
+ال culture media غالبا بيكون contain ال hat medium
+
+627
+00:53:41,670 --> 00:53:46,030
+اللي هو عبارة عن ال hypo, زنثين, امينو, بترين
+
+628
+00:53:47,460 --> 00:53:52,720
+فايمدينو ميديام طبعا ال بيليمفوسايت تستطيع تستغل
+
+629
+00:53:52,720 --> 00:53:58,480
+هذه ال نيوكليوتايد لتصنيع اللي هو ال DNA بينما ال
+
+630
+00:53:58,480 --> 00:54:02,460
+myeloma cell لا تستطيع لأنها تفقد ال enzyme اللي
+
+631
+00:54:02,460 --> 00:54:10,680
+بيساعد على استغلال هذه ال نيوكليوتايد نشيب هات to
+
+632
+00:54:10,680 --> 00:54:15,120
+grow و بعدين نفحص ل supernatant for antibody
+
+633
+00:54:15,120 --> 00:54:21,780
+productionبناخد ال clone of each positive culture
+
+634
+00:54:21,780 --> 00:54:28,080
+و بنعمله أيه صعب ال culturing برضه بنفحص ال super
+
+635
+00:54:28,080 --> 00:54:32,960
+natant و إذا بدنا نزود عددها إذا عجبنا الخدية و
+
+636
+00:54:32,960 --> 00:54:38,560
+نجحت مية في المية بنزود عددها بزود عددها اما by
+
+637
+00:54:39,420 --> 00:54:43,540
+propagation in vivo روحنا هخلينها برضه في
+
+638
+00:54:43,540 --> 00:54:48,140
+البراتونير كافتي تبعت الفعار فبتبدأ تنمو بكميات
+
+639
+00:54:48,140 --> 00:54:53,380
+كبيرة جدا وبيعتبر culture media محترم جدا او in
+
+640
+00:54:53,380 --> 00:54:57,720
+vitro in subculturing هذا هو نعملها culturing
+
+641
+00:54:57,720 --> 00:55:02,940
+وطبعا بعديك نعمل harvesting للمونوكلون ال antibody
+
+642
+00:55:02,940 --> 00:55:08,160
+ناخدها و بنعملها subculturing و بناخداشطبعا ناخد
+
+643
+00:55:08,160 --> 00:55:12,420
+كل واحدة و نعملها ايش؟ بتدينا clone و ال clone بده
+
+644
+00:55:12,420 --> 00:55:17,240
+يدينا كميات كبيرة من ال monoclonal antibody اللي
+
+645
+00:55:17,240 --> 00:55:23,080
+هي immunized agents يوم اي انسان يتعرض لانتجن
+
+646
+00:55:23,080 --> 00:55:26,900
+الانتجن ممكن يحتوي عليها many epitopes these
+
+647
+00:55:26,900 --> 00:55:31,360
+epitopes will activate many lymphocytes و ال
+
+648
+00:55:31,360 --> 00:55:35,180
+lymphocytes اللي بتتنشط هتدينا many antibodies
+
+649
+00:55:35,180 --> 00:55:40,690
+specific for thedifferent epitopes ماشي في ال 75
+
+650
+00:55:40,690 --> 00:55:46,550
+يعني ظهرت الحاجة لإنه نحتوي على monoclonal
+
+651
+00:55:46,550 --> 00:55:50,250
+antibody بدناش polyclonal طبعا في ال .. في ال ..
+
+652
+00:55:50,250 --> 00:55:54,190
+أول هذا كل اللي بيطلع polyclonal antibody لكن ظهرت
+
+653
+00:55:54,190 --> 00:55:57,710
+الحاجة في ال .. ال monoclonal antibody اللي هو
+
+654
+00:55:57,710 --> 00:56:02,110
+more specific بس بدنا one antibodyوطبعا اللي جام
+
+655
+00:56:02,110 --> 00:56:06,130
+بيها العملية اللي هو Kolar و Milstein في الخمسة
+
+656
+00:56:06,130 --> 00:56:10,610
+وسبعين طوروا عملية تصنيع ال monoclonal antibody
+
+657
+00:56:10,610 --> 00:56:15,370
+واخد عليها ال Nobel Prize و ال monoclonal antibody
+
+658
+00:56:15,370 --> 00:56:17,570
+اللي بيطلع هو برعنة homogeneous population و
+
+659
+00:56:17,570 --> 00:56:20,530
+antibody molecule طلع منه single antibody
+
+660
+00:56:20,530 --> 00:56:23,730
+producing cell واحدة in which all antibody are
+
+661
+00:56:23,730 --> 00:56:24,250
+identical
+
+662
+00:56:30,380 --> 00:56:33,980
+وهي البروسيجال اللى تبعها الكوية بالضبط ماليجنة
+
+663
+00:56:33,980 --> 00:56:38,380
+انتبلازما سيل يعني امورتايل ماعندهاش القدرة انها
+
+664
+00:56:38,380 --> 00:56:43,300
+تنتج اي مينو غلوبيلين ماشي these cells are
+
+665
+00:56:43,300 --> 00:56:47,060
+engineered to be deficient بيشيلوا منها
+
+666
+00:56:47,060 --> 00:56:51,460
+الhypoxanthin guanine phosphoribosyl transferase
+
+667
+00:56:51,460 --> 00:56:55,000
+enzyme وبالتالي it will not survive in a culture
+
+668
+00:56:56,600 --> 00:57:02,520
+طول ما الانزيم هذا مش موجود. These cells are
+
+669
+00:57:02,520 --> 00:57:08,020
+infused يعني hybridized مع freshly harvested B
+
+670
+00:57:08,020 --> 00:57:13,060
+lymphocyte أخدناها من فعها، spleen تبع فعر عرضناها
+
+671
+00:57:13,060 --> 00:57:18,160
+لانتجن سابق ماشي عملنا لهم diffusion و ال
+
+672
+00:57:18,160 --> 00:57:22,120
+diffusion بتم من خلال إضافة مادة كيميائية اسمها
+
+673
+00:57:22,120 --> 00:57:25,260
+polyethylene glycol بتعمل .. بساعد على diffusion
+
+674
+00:57:26,770 --> 00:57:29,610
+طبعاً في هذه الحالة تجعلنا تلت أنواع من الخلايا
+
+675
+00:57:29,610 --> 00:57:33,910
+خلايا بالإنفوسايت ما حصل لهاش fusion ثم hybrid
+
+676
+00:57:33,910 --> 00:57:40,010
+cells حصل لها fusion ثم ال myeloma
+
+677
+00:57:40,010 --> 00:57:46,350
+cell برضه ما شاركتش في ال hybridization ماشي
+
+678
+00:57:46,350 --> 00:57:50,210
+بنحطهم كلهم في culture media شو اللي بيصير قالوا
+
+679
+00:57:50,210 --> 00:57:52,890
+ال antibody producing cell اللي في عندها
+
+680
+00:57:52,890 --> 00:57:55,710
+hypoxanthinأي جوانين
+
+681
+00:57:55,710 --> 00:57:59,530
+فوسفوريابوزيليترانسفيريزيينزاين ستنجح ولكن الانزين
+
+682
+00:57:59,530 --> 00:58:07,730
+لن يموت لغاية ما يخلص حياته و بعد ذلك ستموت والسل
+
+683
+00:58:07,730 --> 00:58:12,810
+الماليجنان لا يملك انزين وبالتالي لن تستطيع أن
+
+684
+00:58:12,810 --> 00:58:18,370
+تصمد في الكلشر فستموت مين بيبقى لعيننا اللي هو ال
+
+685
+00:58:18,370 --> 00:58:24,660
+hybridoma cell هذا السل ستنجحطبعا هذه ممكن نفحصها
+
+686
+00:58:24,660 --> 00:58:29,660
+ببساطة نفحص ال supernatant تبعها by أو ال antibody
+
+687
+00:58:29,660 --> 00:58:37,820
+producing منها by ELISA technique and those cells
+
+688
+00:58:37,820 --> 00:58:44,120
+are cloned وكل clone ممكن تكون انها كمية كبيرة من
+
+689
+00:58:44,120 --> 00:58:47,180
+ال monoclonal antibody with a single specificity
+
+690
+00:58:48,410 --> 00:58:51,290
+استخدام الـ Monoclonal Antibody غالبا تستخدم في
+
+691
+00:58:51,290 --> 00:58:55,510
+الـ Diagnostic Technique وكل فعشاطنا في المختبر
+
+692
+00:58:55,510 --> 00:59:00,830
+تعتمد على الـ Monoclonal Antibody الـ agent كلنا
+
+693
+00:59:00,830 --> 00:59:04,330
+كل الكتات اللي بنستخدمها غالبا هي Monoclonal
+
+694
+00:59:04,330 --> 00:59:08,610
+Antibody الأغلى منها هي عبارة عن Monoclonal
+
+695
+00:59:08,610 --> 00:59:10,670
+Antibody طبعا ال Polycloma اللي بيدينا cross
+
+696
+00:59:10,670 --> 00:59:16,770
+reactivity ومش .. و non specific أيضا تستخدم في ال
+
+697
+00:59:16,770 --> 00:59:22,890
+treatmentof cancer شو اللي بيعملوه اليوم بيربطوه
+
+698
+00:59:22,890 --> 00:59:26,530
+في ديال ال monoclonal antibody ال drug او ال toxin
+
+699
+00:59:26,530 --> 00:59:30,270
+و بيحقنوه في المريض بيضل يجري يجري يجري لغاية ما
+
+700
+00:59:30,270 --> 00:59:33,890
+يصل ال tumor cell او ال infected cell و هناك بيمسك
+
+701
+00:59:33,890 --> 00:59:39,070
+فيها و ال toxin المربوط فيها او ال drug بعمل عملية
+
+702
+00:59:39,070 --> 00:59:43,210
+قتل لها و بالتالي بيصير في targeting therapy
+
+703
+00:59:43,210 --> 00:59:47,510
+بيسموها العملية targeting therapy
+
+704
+00:59:49,380 --> 00:59:55,480
+بهيك بنكون ان هنا المحاضرة اتمنى ان تكونوا يعني قد
+
+705
+00:59:55,480 --> 00:59:58,320
+استفدتم ان شاء الله و شكرا
+
diff --git a/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/LehIRFy0Pm8_raw.json b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/LehIRFy0Pm8_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..424196b184d54b1585e6cbcfa8c507f953cf3bb0
--- /dev/null
+++ b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/LehIRFy0Pm8_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2593, "start": 3.59, "end": 25.93, "text": "بسم الله الرحمن الرحيم اروح حضرتنا اليوم عن ال genetic basis of antibody structure من المعروف اليوم انه في عيننا different antigenic specificity من خلايا ال B lymphocyte وT lymphocyte بيصل عددها إلى عشر قوة من عشر قوة خمستاشر لعشر قوة تمانتاشر يعني في عيندي different B", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 1975, 32887, 5016, 11331, 11242, 43500, 8315, 45595, 20498, 18871, 2423, 1049, 302, 299, 5143, 295, 34507, 3877, 9154, 9673, 3615, 32887, 5172, 45595, 20498, 16472, 3224, 8978, 6225, 9957, 8315, 819, 2511, 3213, 299, 2685, 507, 9154, 16490, 15040, 25528, 2423, 363, 31070, 31078, 975, 4032, 51, 31070, 31078, 975, 4724, 1829, 36520, 6225, 3215, 3215, 11296, 30731, 6225, 46309, 12174, 2407, 3660, 9154, 6225, 46309, 12174, 2407, 3660, 16490, 2304, 14851, 33599, 2288, 5296, 3615, 46309, 12174, 2407, 3660, 46811, 7649, 2655, 33599, 2288, 37495, 22653, 8978, 6225, 9957, 16254, 819, 363], "avg_logprob": -0.223407455934928, "compression_ratio": 1.7241379310344827, "no_speech_prob": 5.364418029785156e-07, "words": [{"start": 3.59, "end": 3.89, "word": "بسم", "probability": 0.795166015625}, {"start": 3.89, "end": 4.09, "word": " الله", "probability": 0.91943359375}, {"start": 4.09, "end": 4.43, "word": " الرحمن", "probability": 0.9641927083333334}, {"start": 4.43, "end": 4.93, "word": " الرحيم", "probability": 0.9943033854166666}, {"start": 4.93, "end": 5.25, "word": " اروح", "probability": 0.477294921875}, {"start": 5.25, "end": 5.65, "word": " حضرتنا", "probability": 0.7806396484375}, {"start": 5.65, "end": 6.01, "word": " اليوم", "probability": 0.90625}, {"start": 6.01, "end": 6.23, "word": " عن", "probability": 0.9443359375}, {"start": 6.23, "end": 6.31, "word": " ال", "probability": 0.84326171875}, {"start": 6.31, "end": 6.73, "word": " genetic", "probability": 0.708740234375}, {"start": 6.73, "end": 7.11, "word": " basis", "probability": 0.88427734375}, 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{"start": 22.03, "end": 22.27, "word": " عشر", "probability": 0.92529296875}, {"start": 22.27, "end": 22.49, "word": " قوة", "probability": 0.9508463541666666}, {"start": 22.49, "end": 22.97, "word": " خمستاشر", "probability": 0.83779296875}, {"start": 22.97, "end": 23.27, "word": " لعشر", "probability": 0.7067057291666666}, {"start": 23.27, "end": 23.49, "word": " قوة", "probability": 0.9503580729166666}, {"start": 23.49, "end": 24.41, "word": " تمانتاشر", "probability": 0.8873046875}, {"start": 24.41, "end": 24.77, "word": " يعني", "probability": 0.850341796875}, {"start": 24.77, "end": 24.89, "word": " في", "probability": 0.93017578125}, {"start": 24.89, "end": 25.17, "word": " عيندي", "probability": 0.7566731770833334}, {"start": 25.17, "end": 25.57, "word": " different", "probability": 0.93896484375}, {"start": 25.57, "end": 25.93, "word": " B", "probability": 0.6611328125}], "temperature": 1.0}, {"id": 2, "seek": 4944, "start": 27.4, "end": 49.44, "text": "with different specificity و different T ايضا have different TCR بهذا العدد و these are protein يعني they are genetically coded وبالتالي they need gene for their production", "tokens": [11820, 819, 2685, 507, 4032, 819, 314, 1975, 1829, 11242, 995, 362, 819, 314, 18547, 39627, 15730, 18863, 3215, 3215, 4032, 613, 366, 7944, 37495, 22653, 436, 366, 37582, 34874, 46599, 6027, 2655, 6027, 1829, 436, 643, 12186, 337, 641, 4265], "avg_logprob": -0.23232887295030413, "compression_ratio": 1.3445945945945945, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 27.4, "end": 27.84, "word": "with", "probability": 0.055389404296875}, {"start": 27.84, "end": 29.38, "word": " different", "probability": 0.90234375}, {"start": 29.38, "end": 30.44, "word": " specificity", "probability": 0.939453125}, {"start": 30.44, "end": 30.6, "word": " و", "probability": 0.7763671875}, {"start": 30.6, "end": 30.94, "word": " different", "probability": 0.7392578125}, {"start": 30.94, "end": 31.42, "word": " T", 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يستطيع أن يصنع هذا العدد المهول من ال immunoglobulin أو ال TCR سوسومو توني جاوة", "tokens": [28814, 15040, 14739, 6225, 3215, 3215, 25724, 1829, 8315, 2655, 13672, 1829, 3714, 29245, 23328, 3660, 20193, 6055, 2655, 7435, 995, 2407, 11622, 8978, 25724, 38251, 2423, 2609, 37495, 22653, 20193, 6055, 2655, 7435, 995, 2407, 11622, 6225, 46309, 9957, 5551, 46538, 5296, 9778, 2304, 3794, 3660, 6225, 46309, 9957, 5551, 46538, 6156, 4117, 33911, 23758, 18863, 3215, 3215, 25062, 20292, 1211, 9154, 25724, 1829, 8315, 2655, 7251, 14851, 9566, 40228, 14739, 7251, 9381, 1863, 3615, 23758, 18863, 3215, 3215, 9673, 3224, 12610, 9154, 2423, 13154, 45841, 12176, 259, 34051, 2423, 314, 18547, 8608, 41779, 20498, 2407, 6055, 11536, 1829, 10874, 995, 2407, 3660], "avg_logprob": -0.21741070974440801, "compression_ratio": 1.8258706467661692, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 50.86, "end": 51.14, "word": "إلا", "probability": 0.549072265625}, {"start": 51.14, "end": 51.3, "word": " 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{"id": 10, "seek": 24493, "start": 216.71, "end": 244.93, "text": "ثم ماتشورينج ميسنجرالاني اللى بعدها بينتقل الى ال translation وفي ال endoplasmic reticulum بيتصن على البروتين ما ينطبق طبعا على هذا هذا ينطبق على ال ال immunoglobulin وعلى ال TCR في مقدمة كل DNA sequence في حاجة بيسموها ال Exon", "tokens": [12984, 2304, 3714, 9307, 8592, 13063, 9957, 7435, 3714, 1829, 3794, 1863, 7435, 2288, 6027, 7649, 1829, 13672, 7578, 39182, 11296, 4724, 9957, 2655, 4587, 1211, 2423, 7578, 2423, 12853, 4032, 41185, 2423, 917, 404, 7743, 13195, 1533, 299, 11560, 4724, 36081, 9381, 1863, 15844, 2423, 26890, 35473, 9957, 19446, 7251, 1863, 9566, 3555, 4587, 23032, 3555, 3615, 995, 15844, 23758, 23758, 7251, 1863, 9566, 3555, 4587, 15844, 2423, 2423, 13154, 45841, 12176, 259, 4032, 3615, 23942, 2423, 314, 18547, 8978, 3714, 28543, 46007, 28242, 8272, 8310, 8978, 11331, 26108, 3660, 4724, 1829, 38251, 2407, 11296, 2423, 2111, 266], "avg_logprob": -0.4046874877810478, "compression_ratio": 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"word": " اختصار", "probability": 0.791015625}, {"start": 252.19, "end": 252.33, "word": " ل", "probability": 0.40478515625}, {"start": 252.33, "end": 252.69, "word": " leader", "probability": 0.309326171875}, {"start": 252.69, "end": 253.67, "word": " sequence", "probability": 0.9462890625}, {"start": 253.67, "end": 255.87, "word": " وهذه", "probability": 0.5758056640625}, {"start": 255.87, "end": 256.49, "word": " تقريبا", "probability": 0.9810546875}, {"start": 256.49, "end": 256.87, "word": " code", "probability": 0.8115234375}, {"start": 256.87, "end": 257.15, "word": " for", "probability": 0.87255859375}, {"start": 257.15, "end": 257.51, "word": " ten", "probability": 0.40087890625}, {"start": 257.51, "end": 258.51, "word": " hydrophobic", "probability": 0.82275390625}, {"start": 258.51, "end": 259.93, "word": " amino", "probability": 0.962890625}, {"start": 259.93, "end": 260.49, "word": " acids", "probability": 0.77001953125}, {"start": 260.49, "end": 262.85, "word": " و", 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{"start": 272.25, "end": 272.41, "word": " ال", "probability": 0.95654296875}, {"start": 272.41, "end": 272.65, "word": " leader", "probability": 0.919921875}], "temperature": 1.0}, {"id": 12, "seek": 28855, "start": 274.07, "end": 288.55, "text": "Is to direct the synthesis of polypeptide chain وين توصلها ل ال endoplasmic reticulum وبستصل هناك بستصلها cleaved off تنقطع فبدل ال DNA لحاله", "tokens": [6802, 281, 2047, 264, 30252, 295, 6754, 494, 662, 482, 5021, 4032, 9957, 33427, 36520, 11296, 5296, 2423, 917, 404, 7743, 13195, 1533, 299, 11560, 46599, 14851, 36520, 34105, 4117, 4724, 14851, 36520, 11296, 1233, 12865, 766, 6055, 1863, 47432, 3615, 6156, 3555, 3215, 1211, 2423, 8272, 5296, 5016, 6027, 3224], "avg_logprob": -0.393930298777727, "compression_ratio": 1.1923076923076923, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 274.07, "end": 274.39, "word": "Is", "probability": 0.0270233154296875}, {"start": 274.39, "end": 274.67, "word": " to", "probability": 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sequence اللي موجود في مقدمة ال DNA طبعا هناك في ال endoplasmic reticulum يتصنع اللي هو ال protein اللي احنا بنحكي عليه ثم", "tokens": [1829, 3555, 4587, 7578, 19446, 39896, 4587, 23328, 2423, 8272, 30731, 2423, 917, 404, 7743, 13195, 1533, 299, 11560, 31439, 2423, 5263, 8310, 13672, 1829, 3714, 29245, 23328, 8978, 3714, 28543, 46007, 2423, 8272, 23032, 3555, 3615, 995, 34105, 4117, 8978, 2423, 917, 404, 7743, 13195, 1533, 299, 11560, 7251, 2655, 9381, 1863, 3615, 13672, 1829, 31439, 2423, 7944, 13672, 1829, 1975, 5016, 8315, 44945, 5016, 4117, 1829, 47356, 38637, 2304], "avg_logprob": -0.1933593696190251, "compression_ratio": 1.5917159763313609, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 289.15, "end": 289.49, "word": "يبقى", "probability": 0.59442138671875}, {"start": 289.49, "end": 289.67, "word": " ما", "probability": 0.2529296875}, {"start": 289.67, "end": 290.19, "word": " هيقود", "probability": 0.8216145833333334}, {"start": 290.19, "end": 290.31, "word": " 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0.88525390625}, {"start": 298.19, "end": 298.91, "word": " مقدمة", "probability": 0.9632161458333334}, {"start": 298.91, "end": 299.75, "word": " ال", "probability": 0.94091796875}, {"start": 299.75, "end": 300.29, "word": " DNA", "probability": 0.96435546875}, {"start": 300.29, "end": 301.37, "word": " طبعا", "probability": 0.89892578125}, {"start": 301.37, "end": 301.75, "word": " هناك", "probability": 0.9853515625}, {"start": 301.75, "end": 302.07, "word": " في", "probability": 0.43994140625}, {"start": 302.07, "end": 302.21, "word": " ال", "probability": 0.9296875}, {"start": 302.21, "end": 302.83, "word": " endoplasmic", "probability": 0.9674072265625}, {"start": 302.83, "end": 303.33, "word": " reticulum", "probability": 0.9915364583333334}, {"start": 303.33, "end": 303.99, "word": " يتصنع", "probability": 0.98564453125}, {"start": 303.99, "end": 304.21, "word": " اللي", "probability": 0.941650390625}, {"start": 304.21, "end": 304.55, "word": " هو", "probability": 0.9931640625}, {"start": 304.55, "end": 305.17, "word": " ال", "probability": 0.947265625}, {"start": 305.17, "end": 305.63, "word": " protein", "probability": 0.900390625}, {"start": 305.63, "end": 305.89, "word": " اللي", "probability": 0.949462890625}, {"start": 305.89, "end": 306.07, "word": " احنا", "probability": 0.8688151041666666}, {"start": 306.07, "end": 306.47, "word": " بنحكي", "probability": 0.90966796875}, {"start": 306.47, "end": 306.75, "word": " عليه", "probability": 0.98681640625}, {"start": 306.75, "end": 307.11, "word": " ثم", "probability": 0.9677734375}], "temperature": 1.0}, {"id": 14, "seek": 33451, "start": 307.59, "end": 334.51, "text": "بيتحرك الى الجوجي ابراطس ينتقل الى الجوجي ابراطس ومن هناك بيطلع على ال cell membrane وهذه هي الرحلة الطبيعية لتصنيع اي protein ال variable region و ال constant region of a new globulin are coded by different gene مزال ال variable many variable can يعني bind to one constant", "tokens": [3555, 36081, 5016, 31747, 2423, 7578, 25724, 29245, 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variable region و constant region عشان هيك بيسموها variable light و constant light ال variable light روحها بتتكوّن من 108 amino acid or residue في ال region and this region", "tokens": [3555, 2655, 2655, 4117, 2407, 11703, 1863, 9154, 7006, 4458, 4032, 5754, 4458, 6225, 8592, 7649, 39896, 4117, 4724, 1829, 38251, 2407, 11296, 7006, 1442, 4032, 5754, 1442, 2423, 7006, 1442, 12602, 2407, 5016, 11296, 39894, 2655, 4117, 2407, 11703, 1863, 9154, 41342, 24674, 8258, 420, 34799, 8978, 2423, 4458, 293, 341, 4458], "avg_logprob": -0.2855902639804063, "compression_ratio": 1.509933774834437, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 450.73, "end": 452.05, "word": "بتتكوّن", "probability": 0.7133440290178571}, {"start": 452.05, "end": 452.35, "word": " من", "probability": 0.98291015625}, {"start": 452.35, "end": 452.85, "word": " variable", "probability": 0.43603515625}, {"start": 452.85, "end": 453.43, "word": " region", "probability": 0.91845703125}, {"start": 453.43, "end": 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"end": 725.68, "word": " مهم", "probability": 0.5880126953125}, {"start": 725.68, "end": 726.28, "word": " جدًا", "probability": 0.65594482421875}, {"start": 726.28, "end": 727.36, "word": " في", "probability": 0.5869140625}, {"start": 727.36, "end": 728.12, "word": " الـ", "probability": 0.463623046875}, {"start": 728.12, "end": 728.34, "word": " B", "probability": 0.69873046875}, {"start": 728.34, "end": 728.7, "word": " و", "probability": 0.74072265625}, {"start": 728.7, "end": 729.02, "word": " T", "probability": 0.193359375}, {"start": 729.02, "end": 731.7, "word": "-Lymphocyte", "probability": 0.64365234375}, {"start": 731.7, "end": 736.42, "word": ".عرفنا", "probability": 0.629364013671875}, {"start": 736.42, "end": 736.64, "word": " إن", "probability": 0.375}, {"start": 736.64, "end": 737.0, "word": " الـ", "probability": 0.644775390625}, {"start": 737.0, "end": 737.56, "word": " VDG", "probability": 0.6444498697916666}, {"start": 737.56, "end": 738.34, "word": " Recombinase", 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2423, 1442, 292, 5021, 8717, 8592, 38688, 33251, 16758, 995, 10874, 47302, 3555, 9122, 16758, 995, 25724, 9957, 6055, 3555, 3615, 11296, 3714, 29245, 23328, 8978, 9122, 2288, 20498, 11622, 20498, 568, 9122, 16758, 995, 45164, 4117, 32277], "avg_logprob": -0.3577686810047827, "compression_ratio": 1.8594594594594596, "no_speech_prob": 0.0, "words": [{"start": 749.3, "end": 750.16, "word": "وهي", "probability": 0.5083821614583334}, {"start": 750.16, "end": 750.52, "word": " موجودة", "probability": 0.8057861328125}, {"start": 750.52, "end": 751.32, "word": " فقط", "probability": 0.5655517578125}, {"start": 751.32, "end": 752.6, "word": " في", "probability": 0.74658203125}, {"start": 752.6, "end": 752.68, "word": " الـ", "probability": 0.45465087890625}, {"start": 752.68, "end": 753.0, "word": " B", "probability": 0.65869140625}, {"start": 753.0, "end": 753.52, "word": " و", "probability": 0.80810546875}, {"start": 753.52, "end": 753.56, "word": " الـ", "probability": 0.5096435546875}, {"start": 753.56, "end": 753.9, "word": " T", "probability": 0.80712890625}, {"start": 753.9, "end": 754.96, "word": " لينفوسايتس", "probability": 0.5599714006696429}, {"start": 754.96, "end": 755.32, "word": " يعني", "probability": 0.518157958984375}, {"start": 755.32, "end": 755.84, "word": " وددوهم", "probability": 0.615576171875}, {"start": 755.84, "end": 756.32, "word": " فقط", "probability": 0.929931640625}, {"start": 756.32, "end": 756.96, "word": " موجودين", "probability": 0.981201171875}, {"start": 756.96, "end": 757.14, "word": " في", "probability": 0.982421875}, {"start": 757.14, "end": 757.52, "word": " وين", "probability": 0.6287841796875}, {"start": 757.52, "end": 758.14, "word": " في", "probability": 0.7041015625}, {"start": 758.14, "end": 758.28, "word": " الـ", "probability": 0.741943359375}, {"start": 758.28, "end": 758.48, "word": " B", "probability": 0.6865234375}, {"start": 758.48, "end": 758.72, "word": " و", "probability": 0.97314453125}, {"start": 758.72, "end": 758.98, "word": " الـ", "probability": 0.796630859375}, {"start": 758.98, "end": 759.1, "word": " T", "probability": 0.740234375}, {"start": 759.1, "end": 760.76, "word": " لينفوسايتس", "probability": 0.9610770089285714}, {"start": 760.76, "end": 763.76, "word": " طيب", "probability": 0.8196614583333334}, {"start": 763.76, "end": 764.54, "word": " نطبق", "probability": 0.7742919921875}, {"start": 764.54, "end": 764.8, "word": " احنا", "probability": 0.8513997395833334}, {"start": 764.8, "end": 765.14, "word": " شفنا", "probability": 0.83154296875}, {"start": 765.14, "end": 765.3, "word": " ال", "probability": 0.6171875}, {"start": 765.3, "end": 765.64, "word": " lighted", "probability": 0.6280517578125}, {"start": 765.64, "end": 765.82, "word": " chain", "probability": 0.404052734375}, {"start": 765.82, "end": 766.14, "word": " نشوف", "probability": 0.91650390625}, {"start": 766.14, "end": 767.5, "word": " الكابا", "probability": 0.79443359375}, {"start": 767.5, "end": 769.22, "word": " جايب", "probability": 0.82958984375}, {"start": 769.22, "end": 769.72, "word": " كابا", "probability": 0.8953450520833334}, {"start": 769.72, "end": 771.24, "word": " الجين", "probability": 0.6634521484375}, {"start": 771.24, "end": 773.74, "word": " تبعها", "probability": 0.9068603515625}, {"start": 773.74, "end": 774.5, "word": " موجود", "probability": 0.7235514322916666}, {"start": 774.5, "end": 774.74, "word": " في", "probability": 0.7783203125}, {"start": 774.74, "end": 775.4, "word": " كرومزوم", "probability": 0.774853515625}, {"start": 775.4, "end": 775.74, "word": " 2", "probability": 0.6640625}, {"start": 775.74, "end": 777.46, "word": " كابا", "probability": 0.6844889322916666}, {"start": 777.46, "end": 777.96, "word": " لوكاس", "probability": 0.8483072916666666}], "temperature": 1.0}, {"id": 31, "seek": 80253, "start": 779.71, "end": 802.53, "text": "والـ Rearrangement للـ أو الـ Arrangement للكعبة gene in the germ line is as follows وهدوا انه فيه اربعين different gene مسئولين عن تصنيع ال variable كعبة gene احنا في عندنا V وJ اربعين فقط", "tokens": [2407, 6027, 39184, 1300, 2284, 933, 518, 24976, 39184, 34051, 2423, 39184, 1587, 14521, 518, 5296, 23275, 3615, 49401, 12186, 294, 264, 19858, 1622, 307, 382, 10002, 4032, 3224, 3215, 14407, 16472, 3224, 8978, 3224, 1975, 25513, 3615, 9957, 819, 12186, 47524, 19986, 12610, 9957, 18871, 6055, 9381, 22653, 3615, 2423, 7006, 9122, 3615, 49401, 12186, 1975, 5016, 8315, 8978, 43242, 8315, 691, 4032, 41, 1975, 25513, 3615, 9957, 6156, 47432], "avg_logprob": -0.3402777769499355, "compression_ratio": 1.4804469273743017, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 779.71, "end": 780.35, "word": "والـ", "probability": 0.4044596354166667}, {"start": 780.35, "end": 781.35, "word": " Rearrangement", "probability": 0.80224609375}, {"start": 781.35, "end": 781.83, "word": " للـ", "probability": 0.726806640625}, {"start": 781.83, "end": 782.11, "word": " أو", "probability": 0.2398681640625}, {"start": 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789.77, "word": " انه", "probability": 0.452392578125}, {"start": 789.77, "end": 789.93, "word": " فيه", "probability": 0.79345703125}, {"start": 789.93, "end": 790.59, "word": " اربعين", "probability": 0.8466796875}, {"start": 790.59, "end": 791.37, "word": " different", "probability": 0.7705078125}, {"start": 791.37, "end": 792.31, "word": " gene", "probability": 0.8369140625}, {"start": 792.31, "end": 792.97, "word": " مسئولين", "probability": 0.9052734375}, {"start": 792.97, "end": 793.13, "word": " عن", "probability": 0.916015625}, {"start": 793.13, "end": 793.81, "word": " تصنيع", "probability": 0.990478515625}, {"start": 793.81, "end": 794.49, "word": " ال", "probability": 0.923828125}, {"start": 794.49, "end": 794.97, "word": " variable", "probability": 0.7412109375}, {"start": 794.97, "end": 795.47, "word": " كعبة", "probability": 0.7051188151041666}, {"start": 795.47, "end": 795.83, "word": " gene", "probability": 0.93798828125}, {"start": 795.83, "end": 798.83, "word": " احنا", "probability": 0.9059244791666666}, {"start": 798.83, "end": 798.97, "word": " في", "probability": 0.72265625}, {"start": 798.97, "end": 799.29, "word": " عندنا", "probability": 0.641845703125}, {"start": 799.29, "end": 799.55, "word": " V", "probability": 0.62939453125}, {"start": 799.55, "end": 800.17, "word": " وJ", "probability": 0.658203125}, {"start": 800.17, "end": 801.83, "word": " اربعين", "probability": 0.8955078125}, {"start": 801.83, "end": 802.53, "word": " فقط", "probability": 0.994384765625}], "temperature": 1.0}, {"id": 32, "seek": 82881, "start": 803.11, "end": 828.81, "text": "للـ variable region اللي هم coding for core ال first خمسة وتسعين amino acids في الكعبة variable region طبعا هدولة بيسبقهم قطعة ال leader sequence ماشي و بينهم و بين ال leader sequence في انترنت يعني separated by انترنت", "tokens": [1211, 1211, 39184, 7006, 4458, 13672, 1829, 8032, 2304, 17720, 337, 4965, 2423, 700, 16490, 2304, 3794, 3660, 34683, 3794, 3615, 9957, 24674, 21667, 8978, 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0.9534912109375}, {"start": 814.55, "end": 815.15, "word": " هدولة", "probability": 0.7713623046875}, {"start": 815.15, "end": 816.55, "word": " بيسبقهم", "probability": 0.9728515625}, {"start": 816.55, "end": 817.61, "word": " قطعة", "probability": 0.9879557291666666}, {"start": 817.61, "end": 818.07, "word": " ال", "probability": 0.8564453125}, {"start": 818.07, "end": 818.41, "word": " leader", "probability": 0.8828125}, {"start": 818.41, "end": 819.73, "word": " sequence", "probability": 0.96875}, {"start": 819.73, "end": 821.45, "word": " ماشي", "probability": 0.8042805989583334}, {"start": 821.45, "end": 822.07, "word": " و", "probability": 0.50537109375}, {"start": 822.07, "end": 822.59, "word": " بينهم", "probability": 0.937744140625}, {"start": 822.59, "end": 822.81, "word": " و", "probability": 0.76220703125}, {"start": 822.81, "end": 823.07, "word": " بين", "probability": 0.982421875}, {"start": 823.07, "end": 823.55, "word": " ال", "probability": 0.97265625}, {"start": 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مسئول عن constant region of Kappa lighted chain فبصير في عندي variable genes", "tokens": [10721, 1829, 9154, 36764, 24401, 5296, 9778, 2304, 3794, 3660, 36764, 24401, 1975, 2655, 1863, 9957, 6055, 1211, 9307, 3660, 1975, 25513, 27884, 16490, 2304, 3794, 3660, 28242, 8032, 3215, 12610, 3660, 47524, 19986, 12610, 9957, 18871, 6055, 9381, 22653, 3615, 2423, 691, 43, 1975, 2407, 2423, 691, 591, 25637, 9673, 12984, 6027, 23758, 18871, 591, 25637, 23032, 3555, 3615, 995, 8032, 3215, 12610, 4724, 43500, 3555, 9566, 14407, 44945, 9957, 20666, 5754, 13672, 1829, 3714, 29245, 23328, 9673, 3794, 19986, 12610, 18871, 2423, 2423, 2423, 12186, 13672, 1829, 47524, 19986, 12610, 18871, 5754, 4458, 295, 591, 25637, 1442, 292, 5021, 6156, 3555, 9381, 13546, 8978, 18871, 16254, 7006, 14424], "avg_logprob": -0.27576014533773197, "compression_ratio": 1.7885462555066078, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 860.35, "end": 860.61, "word": "أي", "probability": 0.319427490234375}, 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الجينات", "probability": 0.8551025390625}], "temperature": 1.0}, {"id": 36, "seek": 94356, "start": 917.04, "end": 943.56, "text": "فبجينا شوية جينات V1 V2 من ال segment هذي وجي أربعة وجي خمسة من ال segment بتاعة الجي برضه بيضلوا مرتبطين مع one constant gene of each of cover طبعا بعد هيكة بس اللي هم transcription اللي هذي بتتصفط الجينات صفطت واتصفيت عشفاوي بالمناسبة فكل مرة بيكون جينات مختلفة", "tokens": [5172, 3555, 7435, 1829, 8315, 13412, 2407, 10632, 10874, 1829, 8315, 2655, 691, 16, 691, 17, 9154, 2423, 9469, 8032, 8848, 1829, 49610, 1829, 5551, 25513, 27884, 49610, 1829, 16490, 2304, 3794, 3660, 9154, 2423, 9469, 39894, 995, 27884, 25724, 1829, 4724, 43042, 3224, 4724, 1829, 11242, 1211, 14407, 3714, 43500, 3555, 9566, 9957, 20449, 472, 5754, 12186, 295, 1184, 295, 2060, 23032, 3555, 3615, 995, 39182, 39896, 4117, 3660, 4724, 3794, 13672, 1829, 8032, 2304, 35288, 13672, 1829, 8032, 8848, 1829, 39894, 2655, 9381, 5172, 9566, 25724, 1829, 8315, 2655, 20328, 5172, 9566, 2655, 4032, 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"start": 999.79, "end": 1022.15, "text": "طبعاً زي ما اتفقنا خلاص جينات موجودين في الـ J segment وكل جين من الـ J segment code for تلتاشر amino acid residue من ال 96 لغاية ال 108", "tokens": [9566, 3555, 3615, 995, 14111, 30767, 1829, 19446, 1975, 2655, 5172, 4587, 8315, 16490, 1211, 33546, 10874, 1829, 8315, 2655, 3714, 29245, 23328, 9957, 8978, 2423, 39184, 508, 9469, 4032, 28820, 10874, 9957, 9154, 2423, 39184, 508, 9469, 3089, 337, 6055, 1211, 2655, 33599, 2288, 24674, 8258, 34799, 9154, 2423, 24124, 5296, 17082, 995, 10632, 2423, 41342], "avg_logprob": -0.2533674568965517, "compression_ratio": 1.3157894736842106, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 999.79, "end": 1000.37, "word": "طبعاً", "probability": 0.7023681640625}, {"start": 1000.37, "end": 1000.97, "word": " زي", "probability": 0.5462646484375}, {"start": 1000.97, "end": 1001.05, "word": " ما", "probability": 0.884765625}, {"start": 1001.05, "end": 1001.55, "word": " اتفقنا", "probability": 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الـ", "probability": 0.5582275390625}, {"start": 1143.69, "end": 1144.29, "word": " V2", "probability": 0.727294921875}, {"start": 1144.29, "end": 1145.09, "word": " مع", "probability": 0.89990234375}, {"start": 1145.09, "end": 1145.37, "word": " الـ", "probability": 0.870361328125}, {"start": 1145.37, "end": 1146.27, "word": " J4", "probability": 0.865234375}, {"start": 1146.27, "end": 1147.71, "word": " بعد", "probability": 0.4951171875}, {"start": 1147.71, "end": 1148.05, "word": " ذلك", "probability": 0.79638671875}, {"start": 1148.05, "end": 1148.89, "word": " يوجد", "probability": 0.4800618489583333}, {"start": 1148.89, "end": 1149.53, "word": " Restriction", "probability": 0.75927734375}, {"start": 1149.53, "end": 1149.91, "word": " enzyme", "probability": 0.83447265625}, {"start": 1149.91, "end": 1150.43, "word": " يقطع", "probability": 0.857421875}, {"start": 1150.43, "end": 1150.59, "word": " ال", "probability": 0.44970703125}, {"start": 1150.59, "end": 1150.97, "word": " 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بتتم من خلال restriction enzyme ماشي أولا بيصير looping لل loop formation by making either one turn or two turn", "tokens": [1829, 3555, 4587, 7578, 6225, 42213, 10632, 6055, 9381, 41185, 9566, 25724, 1829, 8315, 2655, 34683, 7435, 2304, 40228, 11331, 7435, 2304, 45030, 25708, 39894, 39237, 9154, 16490, 1211, 6027, 29529, 24521, 3714, 33599, 1829, 5551, 12610, 995, 4724, 1829, 9381, 13546, 6367, 278, 24976, 6367, 11723, 538, 1455, 2139, 472, 1261, 420, 732, 1261], "avg_logprob": -0.35881697333284784, "compression_ratio": 1.2787878787878788, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1168.12, "end": 1168.44, "word": "يبقى", "probability": 0.601043701171875}, {"start": 1168.44, "end": 1168.8, "word": " عملية", "probability": 0.9404296875}, {"start": 1168.8, "end": 1169.28, "word": " تصفيط", "probability": 0.8116455078125}, {"start": 1169.28, "end": 1169.96, "word": " الجينات", "probability": 0.904541015625}, {"start": 1169.96, "end": 1170.48, "word": " وتجميع", 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different gene وبالتالي بيصير في عيننا في ال .. موجود في عيننا في ال germ line DNA before a rearrangement already موجود جينات مسئولة عن هذه عن ال hefe gene كاملة constant و variable طبعا في ال differentiated B lymphocytes", "tokens": [3215, 12610, 6055, 3794, 27884, 819, 12186, 46599, 6027, 2655, 6027, 1829, 4724, 1829, 9381, 13546, 8978, 6225, 9957, 8315, 8978, 2423, 4386, 3714, 29245, 23328, 8978, 6225, 9957, 8315, 8978, 2423, 19858, 1622, 8272, 949, 257, 39568, 518, 1217, 3714, 29245, 23328, 10874, 1829, 8315, 2655, 47524, 19986, 12610, 3660, 18871, 29538, 18871, 2423, 415, 2106, 12186, 9122, 10943, 37977, 5754, 4032, 7006, 23032, 3555, 3615, 995, 8978, 2423, 27372, 770, 363, 31070, 905, 43673], "avg_logprob": -0.29586037877318144, "compression_ratio": 1.5047619047619047, "no_speech_prob": 0.0, "words": [{"start": 1365.05, "end": 1365.35, "word": "دول", "probability": 0.468231201171875}, {"start": 1365.35, "end": 1365.83, "word": " تسعة", "probability": 0.83984375}, {"start": 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"probability": 0.81787109375}, {"start": 1588.42, "end": 1589.06, "word": " خمسين", "probability": 0.9881591796875}, {"start": 1589.06, "end": 1589.48, "word": " different", "probability": 0.935546875}, {"start": 1589.48, "end": 1590.16, "word": " variable", "probability": 0.92919921875}, {"start": 1590.16, "end": 1590.7, "word": " heavy", "probability": 0.77099609375}, {"start": 1590.7, "end": 1591.1, "word": " chain", "probability": 0.890625}], "temperature": 1.0}, {"id": 61, "seek": 161297, "start": 1591.61, "end": 1612.97, "text": "عشرين مختلفة مختلفة وستة مختلفة مجتمع مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة", "tokens": [3615, 46309, 9957, 3714, 46456, 46538, 3660, 3714, 46456, 46538, 3660, 4032, 14851, 3660, 3714, 46456, 46538, 3660, 3714, 7435, 39237, 3615, 3714, 46456, 46538, 3660, 3714, 46456, 46538, 3660, 3714, 46456, 46538, 3660, 3714, 46456, 46538, 3660, 3714, 46456, 46538, 3660, 3714, 46456, 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{"start": 1944.72, "end": 1945.12, "word": " الأب", "probability": 0.953857421875}, {"start": 1945.12, "end": 1945.48, "word": " على", "probability": 0.8095703125}, {"start": 1945.48, "end": 1945.76, "word": " طول", "probability": 0.994140625}, {"start": 1945.76, "end": 1946.48, "word": " بيستبدلوها", "probability": 0.9708426339285714}, {"start": 1946.48, "end": 1946.94, "word": " بجينات", "probability": 0.94541015625}, {"start": 1946.94, "end": 1947.18, "word": " جاية", "probability": 0.9689127604166666}, {"start": 1947.18, "end": 1947.36, "word": " من", "probability": 0.99267578125}, {"start": 1947.36, "end": 1947.68, "word": " الأب", "probability": 0.963623046875}], "temperature": 1.0}, {"id": 74, "seek": 196014, "start": 1949.38, "end": 1960.14, "text": "إذا فشلت عملية التجارب في واحد الكرمزوم، فسيستمر الكرمزوم الثاني بالتجارب في التجارب.", "tokens": [28814, 15730, 6156, 8592, 1211, 2655, 6225, 42213, 10632, 16712, 7435, 9640, 3555, 8978, 36764, 24401, 33251, 2288, 2304, 11622, 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"word": " of", "probability": 0.96044921875}, {"start": 2423.51, "end": 2423.97, "word": " repeating", "probability": 0.93701171875}, {"start": 2423.97, "end": 2424.41, "word": " base", "probability": 0.69189453125}, {"start": 2424.41, "end": 2425.17, "word": " sequence", "probability": 0.974609375}, {"start": 2425.17, "end": 2427.81, "word": " طبعا", "probability": 0.9666748046875}, {"start": 2427.81, "end": 2428.05, "word": " this", "probability": 0.7939453125}, {"start": 2428.05, "end": 2428.53, "word": " region", "probability": 0.96875}, {"start": 2428.53, "end": 2428.87, "word": " S", "probability": 0.5869140625}, {"start": 2428.87, "end": 2429.37, "word": " region", "probability": 0.8544921875}], "temperature": 1.0}, {"id": 92, "seek": 245513, "start": 2430.17, "end": 2455.13, "text": "هي من يسمح of any constant heavy chain gene ماشي قلنا معاها ده constant delta to associate with the VDJ unit وبالتالي بيصير في عنا only the constant heavy gene Gamma 1 Gamma 3 طب الأولى يعني كله 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اللي هو مين الانتيجن والكائن اللي طالع من ال T Cell ايش اللي بيصير قالولا بيسل with the VDG unit Linked Cµ وC دلتا بيصير في ارثر rearrangement", "tokens": [52, 20535, 264, 745, 332, 12162, 11537, 40432, 295, 5130, 3213, 5130, 1438, 3194, 314, 28859, 5618, 3194, 383, 4328, 453, 533, 12174, 1211, 8315, 6055, 33753, 6055, 10721, 12984, 13546, 13672, 1829, 31439, 3714, 9957, 2423, 7649, 31371, 7435, 1863, 16070, 4117, 16373, 1863, 13672, 1829, 23032, 6027, 3615, 9154, 2423, 314, 28859, 1975, 1829, 8592, 13672, 1829, 4724, 1829, 9381, 13546, 50239, 12610, 995, 4724, 1829, 3794, 1211, 365, 264, 691, 35, 38, 4985, 19322, 383, 126, 113, 4032, 34, 11778, 1211, 2655, 995, 4724, 1829, 9381, 13546, 8978, 1975, 2288, 49115, 39568, 518], "avg_logprob": -0.46005154639175255, "compression_ratio": 1.422907488986784, "no_speech_prob": 0.0, "words": [{"start": 2458.75, "end": 2459.25, "word": "Under", "probability": 0.4968109130859375}, {"start": 2459.25, "end": 2459.69, "word": " the", "probability": 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ايش", "probability": 0.678955078125}, {"start": 2475.19, "end": 2475.35, "word": " اللي", "probability": 0.981201171875}, {"start": 2475.35, "end": 2475.75, "word": " بيصير", "probability": 0.87353515625}, {"start": 2475.75, "end": 2476.19, "word": " قالولا", "probability": 0.3095703125}, {"start": 2476.19, "end": 2476.75, "word": " بيسل", "probability": 0.722930908203125}, {"start": 2476.75, "end": 2477.09, "word": " with", "probability": 0.3544921875}, {"start": 2477.09, "end": 2477.25, "word": " the", "probability": 0.29833984375}, {"start": 2477.25, "end": 2477.79, "word": " VDG", "probability": 0.6685384114583334}, {"start": 2477.79, "end": 2478.37, "word": " unit", "probability": 0.6923828125}, {"start": 2478.37, "end": 2479.55, "word": " Linked", "probability": 0.352783203125}, {"start": 2479.55, "end": 2481.71, "word": " Cµ", "probability": 0.5703531901041666}, {"start": 2481.71, "end": 2482.01, "word": " وC", "probability": 0.3800048828125}, {"start": 2482.01, "end": 2482.83, "word": " دلتا", "probability": 0.72967529296875}, {"start": 2482.83, "end": 2483.81, "word": " بيصير", "probability": 0.86083984375}, {"start": 2483.81, "end": 2484.09, "word": " في", "probability": 0.9169921875}, {"start": 2484.09, "end": 2484.57, "word": " ارثر", "probability": 0.6284586588541666}, {"start": 2484.57, "end": 2485.65, "word": " rearrangement", "probability": 0.7017822265625}], "temperature": 1.0}, {"id": 94, "seek": 251558, "start": 2486.88, "end": 2515.58, "text": "عشان الـ VDJ الجديد اللي موجود يرتبط بـ S region in front في مقدمة أي other constant heavy region gene وفي ال figure كان Gamma 1 طبعا بعد ذلك ال primary RNA transcript is made from rearranged DNA و ال introns are spliced out وطلعنا mature messenger RNA", "tokens": [3615, 8592, 7649, 2423, 39184, 691, 48383, 25724, 16254, 3215, 13672, 1829, 3714, 29245, 23328, 7251, 43500, 3555, 9566, 4724, 39184, 318, 4458, 294, 1868, 8978, 3714, 28543, 46007, 36632, 661, 5754, 4676, 4458, 12186, 4032, 41185, 2423, 2573, 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{"start": 2499.24, "end": 2500.36, "word": " وفي", "probability": 0.85400390625}, {"start": 2500.36, "end": 2500.7, "word": " ال", "probability": 0.78515625}, {"start": 2500.7, "end": 2501.1, "word": " figure", "probability": 0.61767578125}, {"start": 2501.1, "end": 2501.66, "word": " كان", "probability": 0.9892578125}, {"start": 2501.66, "end": 2502.22, "word": " Gamma", "probability": 0.7027587890625}, {"start": 2502.22, "end": 2502.64, "word": " 1", "probability": 0.7529296875}, {"start": 2502.64, "end": 2505.26, "word": " طبعا", "probability": 0.9156494140625}, {"start": 2505.26, "end": 2505.5, "word": " بعد", "probability": 0.6298828125}, {"start": 2505.5, "end": 2505.66, "word": " ذلك", "probability": 0.803466796875}, {"start": 2505.66, "end": 2505.84, "word": " ال", "probability": 0.68310546875}, {"start": 2505.84, "end": 2506.16, "word": " primary", "probability": 0.2255859375}, {"start": 2506.16, "end": 2506.76, "word": " RNA", "probability": 0.89208984375}, {"start": 2506.76, "end": 2507.38, "word": " transcript", "probability": 0.80615234375}, {"start": 2507.38, "end": 2507.72, "word": " is", "probability": 0.65478515625}, {"start": 2507.72, "end": 2508.08, "word": " made", "probability": 0.86669921875}, {"start": 2508.08, "end": 2508.34, "word": " from", "probability": 0.8916015625}, {"start": 2508.34, "end": 2508.94, "word": " rearranged", "probability": 0.917724609375}, {"start": 2508.94, "end": 2509.42, "word": " DNA", "probability": 0.890625}, {"start": 2509.42, "end": 2510.46, "word": " و", "probability": 0.471923828125}, {"start": 2510.46, "end": 2510.54, "word": " ال", "probability": 0.71533203125}, {"start": 2510.54, "end": 2511.02, "word": " introns", "probability": 0.49456787109375}, {"start": 2511.02, "end": 2511.88, "word": " are", "probability": 0.908203125}, {"start": 2511.88, "end": 2512.34, "word": " spliced", "probability": 0.746826171875}, {"start": 2512.34, "end": 2512.96, "word": " out", "probability": 0.8828125}, {"start": 2512.96, "end": 2514.04, "word": " وطلعنا", "probability": 0.868359375}, {"start": 2514.04, "end": 2514.54, "word": " mature", "probability": 0.791015625}, {"start": 2514.54, "end": 2515.04, "word": " messenger", "probability": 0.8212890625}, {"start": 2515.04, "end": 2515.58, "word": " RNA", "probability": 0.93359375}], "temperature": 1.0}, {"id": 95, "seek": 254310, "start": 2516.38, "end": 2543.1, "text": "اللي وش كود for IGG-1 Heavy Chain وطبعا intervening C-region DNA is removed في هذه الحالة أو في هذه المرحلة The cell loses its ability to revert to making a class of antibody whose constant region gene has been deleted اللي انمحى اللي انحزف", "tokens": [6027, 20292, 4032, 8592, 9122, 23328, 337, 26367, 38, 12, 16, 26473, 33252, 4032, 9566, 3555, 3615, 995, 17104, 278, 383, 12, 3375, 313, 8272, 307, 7261, 8978, 29538, 21542, 6027, 3660, 34051, 8978, 29538, 9673, 2288, 5016, 37977, 440, 2815, 18293, 1080, 3485, 281, 319, 3281, 281, 1455, 257, 1508, 295, 34507, 6104, 5754, 4458, 12186, 575, 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"word": " intervening", "probability": 0.7088623046875}, {"start": 2522.54, "end": 2522.86, "word": " C", "probability": 0.50830078125}, {"start": 2522.86, "end": 2523.44, "word": "-region", "probability": 0.7115885416666666}, {"start": 2523.44, "end": 2524.1, "word": " DNA", "probability": 0.880859375}, {"start": 2524.1, "end": 2524.4, "word": " is", "probability": 0.82177734375}, {"start": 2524.4, "end": 2524.92, "word": " removed", "probability": 0.837890625}, {"start": 2524.92, "end": 2527.12, "word": " في", "probability": 0.68115234375}, {"start": 2527.12, "end": 2527.42, "word": " هذه", "probability": 0.8837890625}, {"start": 2527.42, "end": 2527.96, "word": " الحالة", "probability": 0.9861653645833334}, {"start": 2527.96, "end": 2528.08, "word": " أو", "probability": 0.52294921875}, {"start": 2528.08, "end": 2528.18, "word": " في", "probability": 0.95166015625}, {"start": 2528.18, "end": 2528.34, "word": " هذه", "probability": 0.98095703125}, {"start": 2528.34, "end": 2529.0, "word": " المرحلة", "probability": 0.993408203125}, {"start": 2529.0, "end": 2529.72, "word": " The", "probability": 0.1307373046875}, {"start": 2529.72, "end": 2530.1, "word": " cell", "probability": 0.83935546875}, {"start": 2530.1, "end": 2530.92, "word": " loses", "probability": 0.8359375}, {"start": 2530.92, "end": 2531.66, "word": " its", "probability": 0.84033203125}, {"start": 2531.66, "end": 2532.24, "word": " ability", "probability": 0.95458984375}, {"start": 2532.24, "end": 2532.54, "word": " to", "probability": 0.9404296875}, {"start": 2532.54, "end": 2533.16, "word": " revert", "probability": 0.734375}, {"start": 2533.16, "end": 2534.0, "word": " to", "probability": 0.77978515625}, {"start": 2534.0, "end": 2534.42, "word": " making", "probability": 0.90478515625}, {"start": 2534.42, "end": 2534.66, "word": " a", "probability": 0.97705078125}, {"start": 2534.66, "end": 2535.06, "word": " class", "probability": 0.97802734375}, {"start": 2535.06, "end": 2535.2, "word": " of", "probability": 0.9775390625}, {"start": 2535.2, "end": 2535.76, "word": " antibody", "probability": 0.943359375}, {"start": 2535.76, "end": 2536.94, "word": " whose", "probability": 0.5185546875}, {"start": 2536.94, "end": 2537.64, "word": " constant", "probability": 0.92236328125}, {"start": 2537.64, "end": 2538.06, "word": " region", "probability": 0.81494140625}, {"start": 2538.06, "end": 2538.4, "word": " gene", "probability": 0.9736328125}, {"start": 2538.4, "end": 2538.66, "word": " has", "probability": 0.89208984375}, {"start": 2538.66, "end": 2538.92, "word": " been", "probability": 0.90966796875}, {"start": 2538.92, "end": 2539.44, "word": " deleted", "probability": 0.921875}, {"start": 2539.44, "end": 2540.06, "word": " اللي", "probability": 0.906494140625}, {"start": 2540.06, "end": 2540.74, "word": " انمحى", "probability": 0.8924560546875}, {"start": 2540.74, "end": 2541.6, "word": " اللي", "probability": 0.874755859375}, {"start": 2541.6, "end": 2543.1, "word": " انحزف", "probability": 0.872802734375}], "temperature": 1.0}, {"id": 96, "seek": 257253, "start": 2543.63, "end": 2572.53, "text": "من الـ constant gene ما بنفع الخلية ترجع تصنع منه تاني Class-watching is a mechanism unique to immunoglobulin-inhibited chain أو B cell and it allows an antibody with a single antigenic specificity to associate with variety of different constant region in a chain وبالتالي بيصير فينا different effector function", "tokens": [27842, 2423, 39184, 5754, 12186, 19446, 44945, 5172, 3615, 33962, 1211, 10632, 6055, 47341, 3615, 6055, 9381, 1863, 3615, 9154, 3224, 6055, 7649, 1829, 9471, 12, 15219, 278, 307, 257, 7513, 3845, 281, 13154, 45841, 12176, 259, 12, 259, 5455, 1226, 5021, 34051, 363, 2815, 293, 309, 4045, 364, 34507, 365, 257, 2167, 2511, 3213, 299, 2685, 507, 281, 14644, 365, 5673, 295, 819, 5754, 4458, 294, 257, 5021, 46599, 6027, 2655, 6027, 1829, 4724, 1829, 9381, 13546, 8978, 8315, 819, 1802, 284, 2445], "avg_logprob": -0.2639705826254452, "compression_ratio": 1.3976833976833978, "no_speech_prob": 0.0, "words": [{"start": 2543.63, "end": 2543.93, "word": "من", "probability": 0.5537109375}, {"start": 2543.93, "end": 2544.13, "word": " الـ", "probability": 0.6317138671875}, {"start": 2544.13, "end": 2544.47, "word": " constant", "probability": 0.2412109375}, {"start": 2544.47, "end": 2544.87, "word": " gene", "probability": 0.73974609375}, {"start": 2544.87, "end": 2545.05, "word": " ما", "probability": 0.403564453125}, {"start": 2545.05, "end": 2545.47, "word": " بنفع", "probability": 0.6775716145833334}, {"start": 2545.47, "end": 2545.99, "word": " الخلية", "probability": 0.9456380208333334}, {"start": 2545.99, "end": 2546.45, "word": " ترجع", "probability": 0.9490559895833334}, {"start": 2546.45, "end": 2546.93, "word": " تصنع", "probability": 0.9136962890625}, {"start": 2546.93, "end": 2547.25, "word": " منه", "probability": 0.983154296875}, {"start": 2547.25, "end": 2547.77, "word": " تاني", "probability": 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"word": " B", "probability": 0.182861328125}, {"start": 2557.31, "end": 2557.75, "word": " cell", "probability": 0.54345703125}, {"start": 2557.75, "end": 2559.39, "word": " and", "probability": 0.7421875}, {"start": 2559.39, "end": 2559.55, "word": " it", "probability": 0.95703125}, {"start": 2559.55, "end": 2560.01, "word": " allows", "probability": 0.859375}, {"start": 2560.01, "end": 2560.25, "word": " an", "probability": 0.89990234375}, {"start": 2560.25, "end": 2560.77, "word": " antibody", "probability": 0.953125}, {"start": 2560.77, "end": 2561.25, "word": " with", "probability": 0.9228515625}, {"start": 2561.25, "end": 2561.43, "word": " a", "probability": 0.9677734375}, {"start": 2561.43, "end": 2561.89, "word": " single", "probability": 0.94287109375}, {"start": 2561.89, "end": 2562.61, "word": " antigenic", "probability": 0.9026692708333334}, {"start": 2562.61, "end": 2563.51, "word": " specificity", "probability": 0.98828125}, {"start": 2563.51, "end": 2563.71, "word": " to", "probability": 0.96240234375}, {"start": 2563.71, "end": 2564.21, "word": " associate", "probability": 0.880859375}, {"start": 2564.21, "end": 2564.55, "word": " with", "probability": 0.91845703125}, {"start": 2564.55, "end": 2565.01, "word": " variety", "probability": 0.7705078125}, {"start": 2565.01, "end": 2565.29, "word": " of", "probability": 0.96923828125}, {"start": 2565.29, "end": 2565.63, "word": " different", "probability": 0.87060546875}, {"start": 2565.63, "end": 2566.07, "word": " constant", "probability": 0.91015625}, {"start": 2566.07, "end": 2566.51, "word": " region", "probability": 0.68994140625}, {"start": 2566.51, "end": 2567.33, "word": " in", "probability": 0.380126953125}, {"start": 2567.33, "end": 2567.43, "word": " a", "probability": 0.55078125}, {"start": 2567.43, "end": 2567.65, "word": " chain", "probability": 0.93115234375}, {"start": 2567.65, "end": 2569.59, "word": " وبالتالي", "probability": 0.8958984375}, {"start": 2569.59, "end": 2570.01, "word": " بيصير", "probability": 0.8631591796875}, {"start": 2570.01, "end": 2570.31, "word": " فينا", "probability": 0.65966796875}, {"start": 2570.31, "end": 2571.47, "word": " different", "probability": 0.626953125}, {"start": 2571.47, "end": 2572.15, "word": " effector", "probability": 0.72705078125}, {"start": 2572.15, "end": 2572.53, "word": " function", "probability": 0.81201171875}], "temperature": 1.0}, {"id": 97, "seek": 259382, "start": 2573.64, "end": 2593.82, "text": "هو مثال على ذلك يعني ال VDG unit specific for bacterial antigen may be linked by constant gamma بتطلعنا IGG وطبعا ال IGG هذا دي ارتبط مع ال macro phase اللي لها receptor لل FC portion of IGG", "tokens": [3224, 2407, 50113, 6027, 15844, 29910, 23275, 37495, 22653, 2423, 691, 35, 38, 4985, 2685, 337, 35632, 2511, 3213, 815, 312, 9408, 538, 5754, 15546, 39894, 9566, 1211, 3615, 8315, 26367, 38, 4032, 9566, 3555, 3615, 995, 2423, 26367, 38, 23758, 11778, 1829, 1975, 43500, 3555, 9566, 20449, 2423, 18887, 5574, 13672, 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age", "probability": 0.54345703125}, {"start": 2862.28, "end": 2863.5, "word": " احتمالية", "probability": 0.8984375}, {"start": 2863.5, "end": 2864.54, "word": " حدوث", "probability": 0.9378662109375}, {"start": 2864.54, "end": 2865.0, "word": " او", "probability": 0.814208984375}, {"start": 2865.0, "end": 2866.1, "word": " انتاج", "probability": 0.83154296875}, {"start": 2866.1, "end": 2867.08, "word": " كابا", "probability": 0.8448893229166666}, {"start": 2867.08, "end": 2869.64, "word": " في", "probability": 0.74755859375}, {"start": 2869.64, "end": 2870.08, "word": " عامل", "probability": 0.8981119791666666}, {"start": 2870.08, "end": 2870.52, "word": " تالت", "probability": 0.97998046875}, {"start": 2870.52, "end": 2870.74, "word": " او", "probability": 0.966552734375}, {"start": 2870.74, "end": 2871.18, "word": " رابع", "probability": 0.9835611979166666}, {"start": 2871.18, "end": 2871.56, "word": " اسمه", "probability": 0.9661458333333334}, {"start": 2871.56, "end": 2872.3, 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ايضا بيضيف اضافة تغيير ل ال fab region و هي عبارة عن جزء او ال hyper variable region هي عبارة عن جزء من ال fab region كمان مش بس بيصير عملية deletion ممكن يصير في insertion يعني اضافة", "tokens": [2407, 23032, 3555, 3615, 995, 23758, 16712, 17082, 1829, 13546, 1975, 1829, 11242, 995, 4724, 1829, 11242, 33911, 1975, 11242, 31845, 3660, 6055, 17082, 1829, 13546, 5296, 2423, 5355, 4458, 4032, 39896, 6225, 3555, 9640, 3660, 18871, 10874, 11622, 38207, 1975, 2407, 2423, 9848, 7006, 4458, 39896, 6225, 3555, 9640, 3660, 18871, 10874, 11622, 38207, 9154, 2423, 5355, 4458, 9122, 2304, 7649, 37893, 4724, 3794, 4724, 1829, 9381, 13546, 6225, 42213, 10632, 1103, 302, 313, 3714, 43020, 7251, 9381, 13546, 8978, 8969, 313, 37495, 22653, 1975, 11242, 31845, 3660], "avg_logprob": -0.17560763938559426, "compression_ratio": 1.6978021978021978, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2909.4, "end": 2909.58, "word": "و", "probability": 0.449462890625}, {"start": 2909.58, "end": 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" after", "probability": 0.671875}, {"start": 3185.6, "end": 3185.8, "word": " it", "probability": 0.9580078125}, {"start": 3185.8, "end": 3185.98, "word": " has", "probability": 0.931640625}, {"start": 3185.98, "end": 3186.42, "word": " formed", "probability": 0.92138671875}, {"start": 3186.42, "end": 3186.88, "word": " a", "probability": 0.97314453125}, {"start": 3186.88, "end": 3187.86, "word": " recombined", "probability": 0.9534505208333334}, {"start": 3187.86, "end": 3188.94, "word": " VG", "probability": 0.77099609375}, {"start": 3188.94, "end": 3189.52, "word": " unit", "probability": 0.95263671875}, {"start": 3189.52, "end": 3191.94, "word": ".ماشي،", "probability": 0.803662109375}, {"start": 3191.94, "end": 3192.2, "word": " as", "probability": 0.78173828125}, {"start": 3192.2, "end": 3192.52, "word": " this", "probability": 0.9541015625}, {"start": 3192.52, "end": 3192.92, "word": " process", "probability": 0.86279296875}, {"start": 3192.92, "end": 3193.12, "word": " is", 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diff --git a/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/hvyPC5Qp3dE_raw.json b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/hvyPC5Qp3dE_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..324c11853fcc5d5d3d04615fd7077365db71ccc0
--- /dev/null
+++ b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/hvyPC5Qp3dE_raw.json
@@ -0,0 +1 @@
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"seek": 72958, "start": 701.34, "end": 729.58, "text": "أيو تيرينج هذا شريح طبعا للصيادين هذوله شريح لماذا شرحته على الفيجر أيو تيرينج cell selectively express فوكس بي تلاتة وده عبارة عن transcriptional factor essential for the development and function of CD4 وCD25 and تيرينج ال mutation في فوكس بي تلاتة وجدوا بعمل", "tokens": [10721, 1829, 2407, 6055, 13546, 9957, 7435, 23758, 13412, 16572, 5016, 23032, 3555, 3615, 995, 24976, 9381, 1829, 18513, 9957, 8032, 8848, 12610, 3224, 13412, 16572, 5016, 32767, 45636, 995, 13412, 2288, 33753, 3224, 15844, 27188, 1829, 7435, 2288, 36632, 2407, 6055, 13546, 9957, 7435, 2815, 3048, 3413, 5109, 6156, 2407, 4117, 3794, 4724, 1829, 6055, 1211, 9307, 3660, 4032, 3215, 3224, 6225, 3555, 9640, 3660, 18871, 35288, 304, 5952, 7115, 337, 264, 3250, 293, 2445, 295, 6743, 19, 4032, 16508, 6074, 293, 6055, 13546, 9957, 7435, 2423, 27960, 8978, 6156, 2407, 4117, 3794, 4724, 1829, 6055, 1211, 9307, 3660, 49610, 3215, 14407, 4724, 25957, 1211], "avg_logprob": 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induction of autoimmunity", "tokens": [6027, 39184, 314, 12, 71, 595, 446, 304, 3274, 38902, 32771, 1829, 16758, 2423, 39184, 314, 12, 71, 595, 446, 304, 3274, 307, 6615, 365, 38199, 40094, 4752, 36632, 11242, 995, 6743, 19, 3353, 314, 2815, 393, 41263, 4871, 264, 33371, 295, 8399, 6753, 45105], "avg_logprob": -0.43817933810793835, "compression_ratio": 1.25, "no_speech_prob": 0.0, "words": [{"start": 943.38, "end": 943.7, "word": "الـ", "probability": 0.53759765625}, {"start": 943.7, "end": 943.94, "word": " T", "probability": 0.388427734375}, {"start": 943.94, "end": 944.94, "word": "-hepartalata", "probability": 0.5789693196614584}, {"start": 944.94, "end": 945.82, "word": " differentiation", "probability": 0.08392333984375}, {"start": 945.82, "end": 948.24, "word": " غياب", "probability": 0.9108072916666666}, {"start": 948.24, "end": 948.38, "word": " الـ", "probability": 0.6611328125}, {"start": 948.38, "end": 948.5, "word": " T", "probability": 0.888671875}, {"start": 948.5, 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2352.94, "end": 2354.08, "word": " فيه", "probability": 0.847412109375}, {"start": 2354.08, "end": 2354.24, "word": " loss", "probability": 0.9150390625}, {"start": 2354.24, "end": 2354.48, "word": " لل", "probability": 0.85302734375}, {"start": 2354.48, "end": 2354.86, "word": " NK", "probability": 0.75830078125}, {"start": 2354.86, "end": 2355.2, "word": " cell", "probability": 0.91552734375}], "temperature": 1.0}, {"id": 94, "seek": 237826, "start": 2356.04, "end": 2378.26, "text": "و بينما ال بي لينفوسايت بقى موجودة بينما هنا برضه ال IAL7 ريسبتور يوم ما يكون فيه هذا هي defect in IAL7 ريسبتور مش موجودة هذا هو بيصير فيه الاصلة T cell بينما ال B cell و ال NK cell still there", "tokens": [2407, 49374, 15042, 2423, 4724, 1829, 5296, 9957, 5172, 41779, 995, 36081, 4724, 4587, 7578, 3714, 29245, 23328, 3660, 49374, 15042, 34105, 4724, 43042, 3224, 2423, 286, 3427, 22, 12602, 1829, 35457, 2655, 13063, 7251, 20498, 19446, 7251, 30544, 8978, 3224, 23758, 39896, 16445, 294, 286, 3427, 22, 12602, 1829, 35457, 2655, 13063, 37893, 3714, 29245, 23328, 3660, 23758, 31439, 4724, 1829, 9381, 13546, 8978, 3224, 2423, 33546, 37977, 314, 2815, 49374, 15042, 2423, 363, 2815, 4032, 2423, 426, 42, 2815, 920, 456], "avg_logprob": -0.40290179210049765, "compression_ratio": 1.7118644067796611, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2356.04, "end": 2356.36, "word": "و", "probability": 0.47802734375}, {"start": 2356.36, "end": 2356.98, "word": " بينما", "probability": 0.854248046875}, {"start": 2356.98, "end": 2357.1, "word": " ال", "probability": 0.60595703125}, {"start": 2357.1, "end": 2357.22, "word": " بي", "probability": 0.44952392578125}, {"start": 2357.22, "end": 2357.88, "word": " لينفوسايت", "probability": 0.73681640625}, {"start": 2357.88, "end": 2358.32, "word": " بقى", "probability": 0.4389241536458333}, {"start": 2358.32, "end": 2359.32, "word": " موجودة", "probability": 0.602020263671875}, {"start": 2359.32, "end": 2360.86, "word": " بينما", "probability": 0.812744140625}, {"start": 2360.86, "end": 2361.22, "word": " هنا", "probability": 0.458251953125}, {"start": 2361.22, "end": 2361.74, "word": " برضه", "probability": 0.7915852864583334}, {"start": 2361.74, "end": 2362.02, "word": " ال", "probability": 0.4765625}, {"start": 2362.02, "end": 2362.72, "word": " IAL7", "probability": 0.3187662760416667}, {"start": 2362.72, "end": 2363.44, "word": " ريسبتور", "probability": 0.733837890625}, {"start": 2363.44, "end": 2364.44, "word": " يوم", "probability": 0.861328125}, {"start": 2364.44, "end": 2364.56, "word": " ما", "probability": 0.77099609375}, {"start": 2364.56, "end": 2364.86, "word": " يكون", "probability": 0.97705078125}, {"start": 2364.86, "end": 2366.04, "word": " فيه", "probability": 0.835693359375}, {"start": 2366.04, "end": 2366.32, "word": " هذا", "probability": 0.307861328125}, {"start": 2366.32, "end": 2366.72, "word": " هي", "probability": 0.356201171875}, {"start": 2366.72, "end": 2367.62, "word": " defect", "probability": 0.669921875}, {"start": 2367.62, "end": 2367.96, "word": " in", "probability": 0.77001953125}, {"start": 2367.96, "end": 2369.52, "word": " IAL7", "probability": 0.8981119791666666}, {"start": 2369.52, "end": 2370.3, "word": " ريسبتور", "probability": 0.8240234375}, {"start": 2370.3, "end": 2371.48, "word": " مش", "probability": 0.892578125}, {"start": 2371.48, "end": 2372.4, "word": " موجودة", "probability": 0.988037109375}, {"start": 2372.4, "end": 2373.02, "word": " هذا", "probability": 0.57568359375}, {"start": 2373.02, "end": 2373.12, "word": " هو", "probability": 0.72265625}, {"start": 2373.12, "end": 2373.44, "word": " بيصير", "probability": 0.85546875}, {"start": 2373.44, "end": 2373.64, "word": " فيه", "probability": 0.939453125}, {"start": 2373.64, "end": 2374.04, "word": " الاصلة", "probability": 0.693603515625}, {"start": 2374.04, "end": 2374.26, "word": " T", "probability": 0.82177734375}, {"start": 2374.26, "end": 2374.68, "word": " cell", "probability": 0.783203125}, {"start": 2374.68, "end": 2375.98, "word": " بينما", "probability": 0.980224609375}, {"start": 2375.98, "end": 2376.12, "word": " ال", "probability": 0.90185546875}, {"start": 2376.12, "end": 2376.34, "word": " B", "probability": 0.70458984375}, {"start": 2376.34, "end": 2376.58, "word": " cell", "probability": 0.9560546875}, {"start": 2376.58, "end": 2376.72, "word": " و", "probability": 0.7802734375}, {"start": 2376.72, "end": 2376.82, "word": " ال", "probability": 0.60400390625}, {"start": 2376.82, "end": 2377.2, "word": " NK", "probability": 0.597900390625}, {"start": 2377.2, "end": 2377.52, "word": " cell", "probability": 0.95556640625}, {"start": 2377.52, "end": 2377.9, "word": " still", "probability": 0.410400390625}, {"start": 2377.9, "end": 2378.26, "word": " there", "probability": 0.89599609375}], "temperature": 1.0}, {"id": 95, "seek": 239625, "start": 2380.91, "end": 2396.25, "text": "هذا هو role of mutation in cytokine receptor gene in severe combined immunodeficiency طبعا غيب T cell و K cell يعني فيه infectious states", "tokens": [3224, 15730, 31439, 3090, 295, 27960, 294, 40248, 453, 533, 32264, 12186, 294, 8922, 9354, 13154, 1429, 1786, 7848, 23032, 3555, 3615, 995, 32771, 1829, 3555, 314, 2815, 4032, 591, 2815, 37495, 22653, 8978, 3224, 26780, 4368], "avg_logprob": -0.3048930944580781, "compression_ratio": 1.1544117647058822, "no_speech_prob": 0.0, "words": [{"start": 2380.91, "end": 2381.07, "word": "هذا", "probability": 0.563232421875}, {"start": 2381.07, "end": 2381.49, "word": " هو", "probability": 0.88623046875}, {"start": 2381.49, "end": 2382.95, "word": " role", "probability": 0.06341552734375}, {"start": 2382.95, "end": 2383.29, "word": " of", "probability": 0.96044921875}, {"start": 2383.29, "end": 2383.95, "word": " mutation", "probability": 0.79736328125}, {"start": 2383.95, "end": 2384.61, "word": " in", "probability": 0.92724609375}, {"start": 2384.61, "end": 2385.25, "word": " cytokine", "probability": 0.9342447916666666}, {"start": 2385.25, "end": 2385.93, "word": " receptor", "probability": 0.78759765625}, {"start": 2385.93, "end": 2387.33, "word": " gene", "probability": 0.76416015625}, {"start": 2387.33, "end": 2387.69, "word": " in", "probability": 0.93994140625}, {"start": 2387.69, "end": 2388.17, "word": " severe", "probability": 0.77978515625}, {"start": 2388.17, "end": 2388.87, "word": " combined", "probability": 0.59619140625}, {"start": 2388.87, "end": 2390.27, "word": " immunodeficiency", "probability": 0.97265625}, {"start": 2390.27, "end": 2390.97, "word": " طبعا", "probability": 0.8690185546875}, {"start": 2390.97, "end": 2391.31, "word": " غيب", "probability": 0.78515625}, {"start": 2391.31, "end": 2391.55, "word": " T", "probability": 0.6962890625}, {"start": 2391.55, "end": 2391.85, "word": " cell", "probability": 0.5498046875}, {"start": 2391.85, "end": 2391.95, "word": " و", "probability": 0.966796875}, {"start": 2391.95, "end": 2392.19, "word": " K", "probability": 0.230712890625}, {"start": 2392.19, "end": 2392.59, "word": " cell", "probability": 0.91015625}, {"start": 2392.59, "end": 2392.91, "word": " يعني", "probability": 0.823974609375}, {"start": 2392.91, "end": 2394.03, "word": " فيه", "probability": 0.76513671875}, {"start": 2394.03, "end": 2394.39, "word": " infectious", "probability": 0.56591796875}, {"start": 2394.39, "end": 2396.25, "word": " states", "probability": 0.97802734375}], "temperature": 1.0}, {"id": 96, "seek": 242109, "start": 2397.93, "end": 2421.09, "text": "ماشي و أيها نفس الحكاية telephosites غيابة بيعمل severe compound لإن هي اللي بتوزع الأدوار و هي المهمة جدا في ال immune response بعد ان نكون خلصنا المحاضرة نتمنى ان تكون غطينا اللي هو ال immune response regulatory factors", "tokens": [2304, 33599, 1829, 4032, 36632, 11296, 8717, 36178, 21542, 4117, 995, 10632, 4304, 950, 329, 3324, 32771, 1829, 16758, 3660, 4724, 1829, 25957, 1211, 8922, 14154, 5296, 28814, 1863, 39896, 13672, 1829, 39894, 2407, 11622, 3615, 16247, 3215, 2407, 9640, 4032, 39896, 9673, 16095, 3660, 10874, 28259, 8978, 2423, 11992, 4134, 39182, 16472, 8717, 30544, 16490, 1211, 9381, 8315, 9673, 5016, 46958, 25720, 8717, 2655, 27842, 7578, 16472, 6055, 30544, 32771, 9566, 1829, 8315, 13672, 1829, 31439, 2423, 11992, 4134, 18260, 6771], "avg_logprob": -0.3111822339425604, "compression_ratio": 1.5205479452054795, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 2397.9300000000003, "end": 2398.9700000000003, "word": "ماشي", "probability": 0.5728352864583334}, {"start": 2398.9700000000003, "end": 2400.01, "word": " و", "probability": 0.481201171875}, {"start": 2400.01, "end": 2401.41, "word": " أيها", "probability": 0.56005859375}, {"start": 2401.41, "end": 2401.69, "word": " نفس", "probability": 0.938232421875}, {"start": 2401.69, "end": 2402.15, "word": " الحكاية", "probability": 0.963623046875}, {"start": 2402.15, "end": 2403.17, "word": " telephosites", "probability": 0.392181396484375}, {"start": 2403.17, "end": 2403.79, "word": " غيابة", "probability": 0.828125}, {"start": 2403.79, "end": 2404.47, "word": " بيعمل", "probability": 0.8619384765625}, {"start": 2404.47, "end": 2405.21, "word": " severe", "probability": 0.12890625}, {"start": 2405.21, "end": 2405.89, "word": " compound", "probability": 0.30712890625}, {"start": 2405.89, "end": 2406.73, "word": " لإن", "probability": 0.7923177083333334}, {"start": 2406.73, "end": 2406.99, "word": " هي", "probability": 0.474365234375}, {"start": 2406.99, "end": 2407.15, "word": " اللي", "probability": 0.763671875}, {"start": 2407.15, "end": 2407.83, "word": " بتوزع", "probability": 0.958251953125}, {"start": 2407.83, "end": 2408.35, "word": " الأدوار", "probability": 0.981201171875}, {"start": 2408.35, "end": 2408.47, "word": " و", "probability": 0.5322265625}, {"start": 2408.47, "end": 2408.59, "word": " هي", "probability": 0.76123046875}, {"start": 2408.59, "end": 2409.13, "word": " المهمة", "probability": 0.9812825520833334}, {"start": 2409.13, "end": 2409.41, "word": " جدا", "probability": 0.945556640625}, {"start": 2409.41, "end": 2409.57, "word": " في", "probability": 0.736328125}, {"start": 2409.57, "end": 2409.65, "word": " ال", "probability": 0.95654296875}, {"start": 2409.65, "end": 2409.95, "word": " immune", "probability": 0.8408203125}, {"start": 2409.95, "end": 2411.43, "word": " response", "probability": 0.93408203125}, {"start": 2411.43, "end": 2412.61, "word": " بعد", "probability": 0.175537109375}, {"start": 2412.61, "end": 2412.81, "word": " ان", "probability": 0.611328125}, {"start": 2412.81, "end": 2413.03, "word": " نكون", "probability": 0.51025390625}, {"start": 2413.03, "end": 2413.55, "word": " خلصنا", "probability": 0.9737548828125}, {"start": 2413.55, "end": 2414.35, "word": " المحاضرة", "probability": 0.9765625}, {"start": 2414.35, "end": 2415.63, "word": " نتمنى", "probability": 0.7818603515625}, {"start": 2415.63, "end": 2415.75, "word": " ان", "probability": 0.53125}, {"start": 2415.75, "end": 2416.03, "word": " تكون", "probability": 0.572021484375}, {"start": 2416.03, "end": 2416.59, "word": " غطينا", "probability": 0.951171875}, {"start": 2416.59, "end": 2416.77, "word": " اللي", "probability": 0.878173828125}, {"start": 2416.77, "end": 2416.97, "word": " هو", "probability": 0.9248046875}, {"start": 2416.97, "end": 2417.09, "word": " ال", "probability": 0.8349609375}, {"start": 2417.09, "end": 2417.45, "word": " immune", "probability": 0.6708984375}, {"start": 2417.45, "end": 2418.79, "word": " response", "probability": 0.90625}, {"start": 2418.79, "end": 2419.45, "word": " regulatory", "probability": 0.884765625}, {"start": 2419.45, "end": 2421.09, "word": " factors", "probability": 0.962890625}], "temperature": 1.0}, {"id": 97, "seek": 242938, "start": 2426.32, "end": 2429.38, "text": "شكرين حسن الاستماع", "tokens": [8592, 37983, 9957, 11331, 3794, 1863, 42963, 14851, 15042, 3615], "avg_logprob": -0.19904119047251614, "compression_ratio": 0.8292682926829268, "no_speech_prob": 0.0, "words": [{"start": 2426.32, "end": 2427.26, "word": "شكرين", "probability": 0.7184244791666666}, {"start": 2427.26, "end": 2428.42, "word": " حسن", "probability": 0.8570963541666666}, {"start": 2428.42, "end": 2429.38, "word": " الاستماع", "probability": 0.921875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2432.4528125, "duration_after_vad": 2302.7418749999924}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/k6fYGUa0Alk.srt b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/k6fYGUa0Alk.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e2628c70b290c11bc5b1d447883305acdc73a961
--- /dev/null
+++ b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/k6fYGUa0Alk.srt
@@ -0,0 +1,1955 @@
+1
+00:00:03,760 --> 00:00:07,740
+بسم الله الرحمن الرحيم نلتقي الآن في تكملة جزء
+
+2
+00:00:07,740 --> 00:00:14,560
+ثاني من المحاضرة والتي هي بعنوان immunodeficiency
+
+3
+00:00:14,560 --> 00:00:18,460
+شرحنا في المحاضرة الأولى الـ primary
+
+4
+00:00:18,460 --> 00:00:21,100
+immunodeficiency disease واليوم إن شاء الله هنحكي
+
+5
+00:00:21,100 --> 00:00:24,520
+على الـ secondary immunodeficiency والـ secondary
+
+6
+00:00:24,520 --> 00:00:28,140
+immunodeficiency من الاسم هي عبارة عن مضاعفات 
+
+7
+00:00:28,140 --> 00:00:33,120
+لأمراض معينة أثرت على جهاز المناعة وبالتالي نتج
+
+8
+00:00:33,120 --> 00:00:42,380
+immunodeficiency syndrome أو disease أشهر
+
+9
+00:00:42,380 --> 00:00:47,280
+أسبابها هو الـ malnutrition وأيضا من أشهر أسبابها
+
+10
+00:00:47,280 --> 00:00:54,860
+هو مضاعفات بعض العلاجات أشهرها كيموثيرابي
+
+11
+00:00:54,860 --> 00:00:58,620
+Chemotherapeutic agents أو immunosuppressive في
+
+12
+00:00:58,620 --> 00:01:05,300
+حالات كمان الـ cancer كمان الـ immunosuppressive
+
+13
+00:01:05,300 --> 00:01:08,520
+treatment في حالات transplantation أو الـ
+
+14
+00:01:08,520 --> 00:01:12,980
+autoimmune disease بـ immunosuppression أيضا
+
+15
+00:01:12,980 --> 00:01:17,440
+ممكن نشوفها في حالات الـ autoimmune disease with
+
+16
+00:01:17,440 --> 00:01:23,480
+overwhelming infection أيضا malignancies بتؤدي إلى
+
+17
+00:01:23,480 --> 00:01:32,240
+الـ secondary اللي هو immunodeficiency disease طبعا
+
+18
+00:01:32,240 --> 00:01:35,140
+أشهر هذه الحالات هي acquired immunodeficiency
+
+19
+00:01:35,140 --> 00:01:41,620
+syndrome اللي هو الـ AIDS وكلنا بنعرف ويروس الـ AIDS
+
+20
+00:01:41,620 --> 00:01:47,460
+أخذناه في الـ virology هذا هو هنتطرق لأشهر هذه الـ
+
+21
+00:01:47,460 --> 00:01:50,340
+structure والـ component of such
+
+22
+00:01:56,160 --> 00:02:02,380
+HIV هو الفيروس اللي شوفنا الـ HIV هو الفيروس اللي
+
+23
+00:02:02,380 --> 00:02:05,340
+شوفنا الـ HIV هو الفيروس اللي شوفنا الـ HIV هو
+
+24
+00:02:05,340 --> 00:02:05,420
+الفيروس اللي شوفنا الـ HIV هو الفيروس اللي شوفنا
+
+25
+00:02:05,420 --> 00:02:05,620
+الـ HIV هو الفيروس اللي شوفنا الـ HIV هو الفيروس
+
+26
+00:02:05,620 --> 00:02:06,200
+اللي شوفنا الـ HIV هو الفيروس اللي شوفنا الـ HIV
+
+27
+00:02:06,200 --> 00:02:07,480
+هو الفيروس اللي شوفنا الـ HIV هو الفيروس اللي
+
+28
+00:02:07,480 --> 00:02:09,400
+شوفنا الـ HIV هو الفيروس اللي شوفنا الـ HIV هو
+
+29
+00:02:09,400 --> 00:02:09,460
+الفيروس اللي شوفنا الـ HIV هو الفيروس اللي شوفنا
+
+30
+00:02:09,460 --> 00:02:12,360
+اللي شوفنا الـ HIV هو الفيروس اللي شوفنا الـ HIV
+
+31
+00:02:12,360 --> 00:02:15,580
+هو الفيروس اللي شوفنا الـ HIV هو الفيروس اللي
+
+32
+00:02:15,580 --> 00:02:22,290
+شوفنا الـ HIV هو الفيروس اللي الـ Genome is diploid
+
+33
+00:02:22,290 --> 00:02:28,530
+يتكون من two single strands أخرى عن إيه وبيمتلك
+
+34
+00:02:28,530 --> 00:02:36,090
+characteristics of cone shaped core structure طبعا
+
+35
+00:02:36,090 --> 00:02:39,810
+الـ Gag واحد إيه واحد بيقوى بي represent the main
+
+36
+00:02:39,810 --> 00:02:44,870
+component of the virus هنشوفه الـ HIV is enveloped
+
+37
+00:02:44,870 --> 00:02:50,270
+by lipid bilayer derived from the host cell
+
+38
+00:02:50,270 --> 00:02:55,350
+membrane viral
+
+39
+00:02:55,350 --> 00:03:00,810
+envelope is studded by virtually or virally
+
+40
+00:03:02,690 --> 00:03:04,350
+Glycoprotein انفجار انفجار انفجار انفجار
+
+41
+00:03:04,350 --> 00:03:31,550
+انفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانفجارانف
+
+42
+00:03:35,330 --> 00:03:43,150
+والـ Reverse transcriptase enzyme وبيقولوا
+
+43
+00:03:43,150 --> 00:03:47,970
+أنه بيحتوي
+
+44
+00:03:47,970 --> 00:03:54,670
+على 1200 موليكيول من P24 و AT والـ Reverse
+
+45
+00:03:54,670 --> 00:03:59,730
+transcriptase و 280 من P-Lipoprotein 120
+
+46
+00:04:03,810 --> 00:04:06,770
+أيضا الـ HIV-Variant بيحتوي على number of
+
+47
+00:04:06,770 --> 00:04:10,110
+cellular proteins زي الـ Beta-2 و microglobulin
+
+48
+00:04:10,110 --> 00:04:14,710
+major histocompatibility complex antigen actin and
+
+49
+00:04:14,710 --> 00:04:21,090
+ubiquitin هذه البروتينات مع الـ glycoprotein 120
+
+50
+00:04:21,090 --> 00:04:26,850
+surface protein أو glycoprotein بتمثل الـ adhesion
+
+51
+00:04:26,850 --> 00:04:31,770
+patches وهي ما تمكن الفيروس من cell fusion
+
+52
+00:04:34,500 --> 00:04:41,440
+والـ Penetration الأساسي بالتركيز
+
+53
+00:04:41,440 --> 00:04:46,320
+أيضا على هذه البروتينات نلاحظ أنها تحتوي على
+
+54
+00:04:46,320 --> 00:04:52,560
+pathogenesis غير مشكلة في الواقع مثلًا الـ Virion
+
+55
+00:04:52,560 --> 00:04:56,300
+أساسية Class II الموليكيولية قد تشغل تسلل الرسيبتر
+
+56
+00:04:56,300 --> 00:04:59,300
+تشغل تسلل الرسيبتر تشغل تسلل الرسيبتر تشغل تسلل
+
+57
+00:04:59,300 --> 00:05:01,380
+الرسيبتر تشغل تسلل الرسيبتر تشغل تسلل الرسيبتر تشغل
+
+58
+00:05:01,380 --> 00:05:02,680
+تسلل الرسيبتر تشغل تسلل الرسيبتر تشغل تسلل الرسيبتر
+
+59
+00:05:05,890 --> 00:05:13,090
+أيضا بتأدي إشارة لـ T lymphocytes لقتل نفسها
+
+60
+00:05:13,090 --> 00:05:19,750
+Cellular targets of HIV infection قالوا بت infect
+
+61
+00:05:19,750 --> 00:05:26,710
+CD4 T lymphocyte CD4 positive monocyte macrophage
+
+62
+00:05:26,710 --> 00:05:32,610
+including microglia CD4 Dendritic cell including
+
+63
+00:05:32,610 --> 00:05:33,950
+Langerhans cells
+
+64
+00:05:38,460 --> 00:05:43,960
+ماشي إصابات يعني لـ T lymphocytes والـ antigen
+
+65
+00:05:43,960 --> 00:05:46,560
+presenting cell Attachment follicular dendritic
+
+66
+00:05:46,560 --> 00:05:50,240
+cell in lymph nodes أمثل في الـ peer patches
+
+67
+00:05:50,240 --> 00:05:55,740
+Galactose cerebroside positive cell in brain and
+
+68
+00:05:55,740 --> 00:06:02,790
+gut كلها بتتسبب في الـ CD4 glycoprotein 120
+
+69
+00:06:02,790 --> 00:06:10,530
+interaction هو أكثر يعني interaction مهم major
+
+70
+00:06:10,530 --> 00:06:16,230
+cell surface receptor على الـ HIV هو is the CD4
+
+71
+00:06:16,230 --> 00:06:20,890
+differentiation antigen several chemical receptors
+
+72
+00:06:20,890 --> 00:06:25,850
+act as a core receptor للـ HIV الماكروفاج tropic HIV
+
+73
+00:06:25,850 --> 00:06:31,910
+بيستخدم chemokine receptor سي نمبر 5 ويعطي فقط مستوى
+
+74
+00:06:31,910 --> 00:06:36,430
+عالي من الـ CD4 في أعضاء الحيوانات العضلية
+
+75
+00:06:36,430 --> 00:06:46,080
+الـ Lymphocytic HIV أيضا بيستخدم chemokine رقم 4 الموجود
+
+76
+00:06:46,080 --> 00:06:49,920
+على سطح الـ T lymphocytes لاستخدام عدد مرتفع عالي من
+
+77
+00:06:49,920 --> 00:06:57,080
+الـ CD4 على محطة الـ cell لأن الماكروفاج بتستخدم
+
+78
+00:06:57,080 --> 00:07:00,500
+chemokine رقم 5 وبتحتاج إلى اتصال عالي
+
+79
+00:07:03,890 --> 00:07:11,710
+الـ lymphocyte lymphotropic HIV بيستخدم اللي هو
+
+80
+00:07:11,710 --> 00:07:16,830
+chemokine number four وبيحتاج الـ high density on
+
+81
+00:07:16,830 --> 00:07:23,750
+expression on CD on T cell Genomic organization of
+
+82
+00:07:23,750 --> 00:07:32,390
+HIV وهذا هو هذا الـ genomic organization هذا الترتيب هي
+
+83
+00:07:32,390 --> 00:07:37,990
+الـ long terminal repeat والـ Gag والـ Pol والـ Env هذه أشهر
+
+84
+00:07:37,990 --> 00:07:45,570
+ثلاثة جين موجودين طبعا
+
+85
+00:07:45,570 --> 00:07:49,610
+هي الـ human
+
+86
+00:07:49,610 --> 00:07:54,530
+genome جينوم الـ length بتاعتها ستة من عشرة
+
+87
+00:07:54,530 --> 00:07:59,710
+kilobase يتكون من structure and regulatory
+
+88
+00:07:59,710 --> 00:08:06,470
+sequences الثلاثة والـ أربعة تشير إلى موقع أساسي للحياة
+
+89
+00:08:06,470 --> 00:08:13,110
+الهيوغوية الهيوغوية الهيوغوية
+
+90
+00:08:13,110 --> 00:08:17,470
+الهيوغوية الهيوغوية الهيوغوية الهيوغوية الهيوغوية
+
+91
+00:08:17,470 --> 00:08:18,870
+الهيوغوية الهيوغوية الهيوغوية الهيوغوية الهيوغوية
+
+92
+00:08:18,870 --> 00:08:19,650
+الهيوغوية الهيوغوية الهيوغوية الهيوغوية الهيوغوية
+
+93
+00:08:19,650 --> 00:08:20,810
+الهيوغوية الهيوغوية الهيوغوية الهيوغوية الهيوغوية
+
+94
+00:08:20,810 --> 00:08:24,070
+الهيوغ
+
+95
+00:08:35,440 --> 00:08:44,160
+أيضا والـ reverse transcriptase polymerase والـ Gag
+
+96
+00:08:44,160 --> 00:08:46,740
+والـ Pol gene تعمل تعمل تعمل تعمل تعمل تعمل تعمل
+
+97
+00:08:46,740 --> 00:08:50,420
+تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل
+
+98
+00:08:50,420 --> 00:08:50,520
+تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل
+
+99
+00:08:50,520 --> 00:08:50,540
+تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل
+
+100
+00:08:50,540 --> 00:08:55,440
+تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل
+
+101
+00:08:55,440 --> 00:09:02,170
+تعمل تعمل تبعا لذلك ممكن يتفادى component of their
+
+102
+00:09:02,170 --> 00:09:12,940
+own system long terminal repeat على طرفي الـ genome الـ
+
+103
+00:09:12,940 --> 00:09:15,700
+five الـ three-prime والـ five-prime بيحتوي على
+
+104
+00:09:15,700 --> 00:09:19,640
+enhancer و promoter element ودول ضروريين for
+
+105
+00:09:19,640 --> 00:09:24,920
+transcription. HIV is initially transcribed into a
+
+106
+00:09:24,920 --> 00:09:30,160
+full-length messenger RNA which is translated into
+
+107
+00:09:30,160 --> 00:09:33,020
+structural Gag and Pol protein
+
+108
+00:09:35,910 --> 00:09:39,090
+طبعا single and spliced messenger RNA is necessary
+
+109
+00:09:39,090 --> 00:09:45,150
+for envelope protein formation Regulatory gene زي
+
+110
+00:09:45,150 --> 00:09:53,590
+Tat اللي هو Transactivator أو Transcription من
+
+111
+00:09:53,590 --> 00:09:56,890
+الاسم it regulate replication and accelerate viral
+
+112
+00:09:56,890 --> 00:10:04,350
+protein production بألاف المرات Rev اللي هو
+
+113
+00:10:04,350 --> 00:10:05,570
+regulator of viral
+
+114
+00:10:07,810 --> 00:10:13,270
+بيسمح للـ unspliced messenger RNA أنه يتنقل من النواة
+
+115
+00:10:13,270 --> 00:10:14,270
+يتنقل يتنقل يتنقل يتنقل يتنقل يتنقل
+
+116
+00:10:14,270 --> 00:10:14,490
+يتنقل يتنقل يتنقل يتنقل يتنقل يتنقل
+
+117
+00:10:14,490 --> 00:10:14,910
+يتنقل يتنقل يتنقل يتنقل يتنقل يتنقل
+
+118
+00:10:14,910 --> 00:10:19,430
+يتنقل يتنقل يتنقل يتنقل يتنقل يتنقل
+
+119
+00:10:19,430 --> 00:10:19,990
+يتنقل يتنقل يتنقل يتنقل يتنقل يتنقل
+
+120
+00:10:19,990 --> 00:10:20,230
+يتنقل يتنقل يتنقل يتنقل يتنقل يتنقل
+
+121
+00:10:20,230 --> 00:10:33,610
+يتنقل يتنقل يتنقل يتن
+
+122
+00:10:35,070 --> 00:10:40,710
+Nef negative regulatory factor بيزود الـ HIV
+
+123
+00:10:40,710 --> 00:10:46,850
+replication وبيخلي الفيروس more pathogenic Vpr
+
+124
+00:10:46,850 --> 00:10:51,210
+Viral Protein R بيلعب دور كبير في regulation والـ Viral
+
+125
+00:10:51,210 --> 00:10:55,070
+Enzyme والـ gene expression وهو بيكون مهم جدا 
+
+126
+00:10:55,070 --> 00:11:04,710
+in viral assembly وانفكار الميكروفيجي ويمكن أن يحدث
+
+127
+00:11:04,710 --> 00:11:11,690
+أبوبتوزيس VPU  بروتين U  طبعا هذا بأثر على 
+
+128
+00:11:11,690 --> 00:11:17,570
+ال HIV من
+
+129
+00:11:17,570 --> 00:11:20,790
+the cell surface and contribute to CD4 degradation
+
+130
+00:11:20,790 --> 00:11:23,130
+within the endoplasmic reticulum
+
+131
+00:11:25,650 --> 00:11:29,350
+نشوف الـ infections و ال pathogenesis of HIV جالو
+
+132
+00:11:29,350 --> 00:11:33,090
+during the early phase of HIV infection قبل ما
+
+133
+00:11:33,090 --> 00:11:36,970
+يصير ال conversion ال virus propagate mainly في ال
+
+134
+00:11:36,970 --> 00:11:41,650
+peripheral blood mononuclear cell primary
+
+135
+00:11:41,650 --> 00:11:44,830
+infection may cause temporary depletion of CD4
+
+136
+00:11:44,830 --> 00:11:49,010
+اللي موجودين في ال peripheral blood mononuclear
+
+137
+00:11:49,010 --> 00:11:49,430
+cell
+
+138
+00:11:52,580 --> 00:11:58,440
+هذا figure يوضح لنا تماما الأزرق كما تشاهدون هو
+
+139
+00:11:58,440 --> 00:12:04,860
+number of CD4T lymphocyte في
+
+140
+00:12:04,860 --> 00:12:09,440
+بداية ال infection تكون عالية و تبدأ تغطى لأن ال
+
+141
+00:12:09,440 --> 00:12:12,680
+infection حصل في الـ mononucleic arthrosis
+
+142
+00:12:12,680 --> 00:12:16,640
+peripheral
+
+143
+00:12:19,440 --> 00:12:27,600
+و هي بدت تنزل لل Zero والخط الأحمر هذا بيمثل ال
+
+144
+00:12:27,600 --> 00:12:34,520
+HIV RNA copies في البلازمة كانت قليلة ثم بدت تزيد
+
+145
+00:12:34,520 --> 00:12:40,460
+تزيد تزيد لغاية ما وصلت ل peak عالية ماشي و بعد
+
+146
+00:12:40,460 --> 00:12:46,850
+هيك بتنزل up to certain level بس مش لل Zero و بعدين
+
+147
+00:12:46,850 --> 00:12:50,290
+تبدأ تطلع مرة تانية هذا بيسموها Zero Conversion
+
+148
+00:12:50,290 --> 00:12:54,230
+Area
+
+149
+00:12:55,670 --> 00:13:00,790
+طبعا زي ما أنتم شايفين قسموها إلى مراحل قالوا في
+
+150
+00:13:00,790 --> 00:13:07,190
+primary infection في acute HIV syndrome و بيصير في
+
+151
+00:13:07,190 --> 00:13:13,250
+wide dissemination of virus في ال lymphoid organs
+
+152
+00:13:13,250 --> 00:13:18,830
+ثم في clinical latency by constitutional symptoms
+
+153
+00:13:18,830 --> 00:13:23,130
+و opportunistic disease
+
+154
+00:13:28,090 --> 00:13:33,430
+هو الفجر التاني برضه بتمثلنا CD4 concentration
+
+155
+00:13:33,430 --> 00:13:41,270
+ماشي هيك against اللي هو ال time per month after
+
+156
+00:13:41,270 --> 00:13:46,970
+infection شايفين في البداية كانت ال CD4 ده هي
+
+157
+00:13:46,970 --> 00:13:55,050
+بالأحمر ماشي كانت عالية و بعدين بدت تنزل ماشي
+
+158
+00:13:56,440 --> 00:14:02,240
+الفيروس كابيز أو antigen بيبدأ قليل لكنه بيعلق و
+
+159
+00:14:02,240 --> 00:14:07,640
+بيصلق مستويات عالية مابيبدأ ينزل ماشي في ال
+
+160
+00:14:07,640 --> 00:14:11,640
+circumversion ماشي في فترة معينة ثم بيطلع مرة
+
+161
+00:14:11,640 --> 00:14:17,740
+تانية أنت شايفين انتيبادي علاقة طبعا تكوين انتيبادي
+
+162
+00:14:17,740 --> 00:14:23,490
+تدمين ال glycoprotein 120 طبعا هي في البداية بتكون
+
+163
+00:14:23,490 --> 00:14:28,030
+قليلة أو صفر مابتبدأ تزيد و تزيد و تزيد up to
+
+164
+00:14:28,030 --> 00:14:34,950
+certain level وبعدين برضه تامتحن actually the
+
+165
+00:14:34,950 --> 00:14:37,710
+infection usually resides from cell related immune
+
+166
+00:14:37,710 --> 00:14:42,990
+response من خلال CD8 cytotoxic T cell and human
+
+167
+00:14:42,990 --> 00:14:48,170
+responses had to help virus to help to clear the
+
+168
+00:14:48,170 --> 00:14:55,690
+virus ولكن للأسف الشديد بيصير failure to eradicate
+
+169
+00:14:55,690 --> 00:14:59,770
+HIV infection during asymptomatic period virus is
+
+170
+00:14:59,770 --> 00:15:03,670
+not completely latent but remain active in
+
+171
+00:15:03,670 --> 00:15:08,150
+lymphoid tissue as proved by PCR technique
+
+172
+00:15:08,150 --> 00:15:13,350
+monocytes are resistant to destruction by HIV
+
+173
+00:15:16,500 --> 00:15:22,480
+and they may act as a reservoir كمان بيقعدوا بتخبى
+
+174
+00:15:22,480 --> 00:15:27,420
+فيها اللي هي ال antigen presenting cell as well as
+
+175
+00:15:27,420 --> 00:15:34,220
+a vehicle بتساعد في عملية نقل ال virus from one
+
+176
+00:15:34,220 --> 00:15:38,660
+distance to another بيقولوا جيب ال HIV يالو ال
+
+177
+00:15:38,660 --> 00:15:44,480
+system يتذكر أن أكثر من 40 مليون person أصيبوا به
+
+178
+00:15:44,480 --> 00:15:55,550
+يشبه ال HIV فيروس من يوم طلع لغاية ال 2006 طبعا
+
+179
+00:15:55,550 --> 00:16:02,610
+أشهر هذه المناطق sub-saharan و Africa لحالها فيها
+
+180
+00:16:02,610 --> 00:16:08,730
+25.3 مليون and these people are living with aids
+
+181
+00:16:08,730 --> 00:16:16,420
+في ال 2006 أيضا 4.3 مليون were infected تلاتة مليون
+
+182
+00:16:16,420 --> 00:16:23,000
+منهم ماتوا و أكثر من خمسة و عشرين مليون ماتوا من
+
+183
+00:16:23,000 --> 00:16:26,540
+الـ 2000 و .. من سنة ألف سنة واحد تمانية لغاية
+
+184
+00:16:26,540 --> 00:16:32,100
+الـ 2006 موضوع
+
+185
+00:16:32,100 --> 00:16:35,820
+ال transmission طبعا بينتقل عن طريق ال sexual
+
+186
+00:16:35,820 --> 00:16:40,500
+contact عن طريق ال placental transmission drug injection
+
+187
+00:16:42,190 --> 00:16:47,990
+Percutaneous Occupational Exposure Recipient of
+
+188
+00:16:47,990 --> 00:16:51,690
+Infected Blunt Recipient of Contaminated Organ or
+
+189
+00:16:51,690 --> 00:16:56,470
+Tissue and Breastfeeding كل هذه عوامل يستطيع
+
+190
+00:16:56,470 --> 00:17:00,470
+الفيروس أن ينتقل من خلالها طبعا common
+
+191
+00:17:00,470 --> 00:17:04,430
+opportunistic infection أما الجنانسي is associated
+
+192
+00:17:04,430 --> 00:17:10,290
+with AIDS Opportunistic Infection زي البكتيريا
+
+193
+00:17:10,290 --> 00:17:14,610
+الشرها Mycobacterium Streptococcus Haemophilus
+
+194
+00:17:14,610 --> 00:17:19,070
+Influenza and Salmonella Viruses بتصاحب هذا
+
+195
+00:17:19,070 --> 00:17:24,230
+الموضوع Herpes Simplex and Zoster ويبشتن بالفيروس
+
+196
+00:17:24,230 --> 00:17:30,930
+Adenovirus-CMV Fungi Candida Histoplasma
+
+197
+00:17:30,930 --> 00:17:37,220
+Cryptococcus Aspergillus Coccidioides Protozoa,
+
+198
+00:17:37,660 --> 00:17:43,320
+Toxoplasma, Pneumocystis, Isospora and
+
+199
+00:17:43,320 --> 00:17:51,540
+Cryptosporidium ما لك ناسي زي الـ Kaposi Sarcoma
+
+200
+00:17:54,040 --> 00:17:58,360
+Burkitt-like lymphoma، Hodgkin disease، CNS
+
+201
+00:17:58,360 --> 00:18:03,380
+lymphoma، Immunoblastic sarcoma، peripheral organ
+
+202
+00:18:03,380 --> 00:18:10,100
+lymphoma، Lymphatic pre-leukemia، كلها associated
+
+203
+00:18:10,100 --> 00:18:14,300
+with such disease طب نشوف تأثيرات الـ HIV على
+
+204
+00:18:14,300 --> 00:18:16,580
+ال immune system قالوا بأول حاجة بيصير فيه
+
+205
+00:18:16,580 --> 00:18:20,780
+depletion و CD4 و أصلا بس هي الـ infected و بيصير
+
+206
+00:18:20,780 --> 00:18:24,140
+فيه degrees لـ Deletion ب hypersensitivity لإنه أصلا
+
+207
+00:18:24,140 --> 00:18:29,820
+الـ macrophage كمان is إيش is infected increase
+
+208
+00:18:29,820 --> 00:18:34,280
+susceptibility of opportunistic infection decrease
+
+209
+00:18:34,280 --> 00:18:41,400
+production of IL-2 polyclonal hyper-globulinemia
+
+210
+00:18:42,150 --> 00:18:48,150
+الـ B-cell activation بوريكلونال تلقى خالة بصير في
+
+211
+00:18:48,150 --> 00:18:50,050
+production of auto-antibody وانتبادي وانتبادي
+
+212
+00:18:50,050 --> 00:18:50,810
+وانتبادي وانتبادي وانتبادي وانتبادي وانتبادي
+
+213
+00:18:50,810 --> 00:18:52,810
+وانتبادي وانتبادي وانتبادي وانتبادي وانتبادي
+
+214
+00:18:52,810 --> 00:18:54,010
+وانتبادي وانتبادي وانتبادي وانتبادي وانتبادي
+
+215
+00:18:54,010 --> 00:18:55,170
+وانتبادي وانتبادي وانتبادي وانتبادي وانتبادي
+
+216
+00:18:55,170 --> 00:18:57,210
+وانتبادي وانتبادي وانتبادي وانتبادي وانتبادي
+
+217
+00:18:57,210 --> 00:19:02,130
+وانتبادي وانتبادي وانتبادي وانتبادي وانتبادي و
+
+218
+00:19:03,650 --> 00:19:06,170
+برضه بيصير فيه زيادة في الـ Release of IL-1
+
+219
+00:19:06,170 --> 00:19:11,970
+و Alpha Interferon ودولة Damaging the Tissue Green
+
+220
+00:19:11,970 --> 00:19:15,930
+Serum and Urine Neoprotein بيزيد الـ β2
+
+221
+00:19:15,930 --> 00:19:21,470
+-Microglobulin ولسه ما قعدش HIV Specific Cytotoxic T
+
+222
+00:19:21,470 --> 00:19:27,210
+Cell نفقدها بعد هيك كان فيش CD4 اللي ده فيش CD8
+
+223
+00:19:27,210 --> 00:19:30,630
+وبرضه
+
+224
+00:19:30,630 --> 00:19:37,800
+بيزيد ال Unresponsiveness للـ CD4 ED&SM Prevention
+
+225
+00:19:37,800 --> 00:19:42,800
+and Control by Health Education خلال كل أدوات HIV
+
+226
+00:19:42,800 --> 00:19:45,940
+التعليم
+
+227
+00:19:45,940 --> 00:19:54,060
+Early Diagnosis Blood Supply Testing Early Therapy
+
+228
+00:19:54,060 --> 00:19:58,700
+Counseling Services Special Attention to
+
+229
+00:19:58,700 --> 00:20:03,760
+Demographic Features of the Elderly الـ Housing و ال
+
+230
+00:20:03,760 --> 00:20:07,320
+Prisons و ال Rural Healthcare و ال Immigration and
+
+231
+00:20:07,320 --> 00:20:11,340
+Travel كل هذه مناطق لازم الواحد ياخد باله منها
+
+232
+00:20:11,340 --> 00:20:16,620
+لأنه ممكن يصير فيها تتواجد
+
+233
+00:20:16,620 --> 00:20:24,480
+أسباب انتشار الـ HIV Prevention HIV infection and
+
+234
+00:20:24,480 --> 00:20:28,560
+healthcare worker في ال health worker لازم ياخدوا
+
+235
+00:20:28,560 --> 00:20:32,420
+بالهم أثناء عملية التعامل مع ال HIV infection من
+
+236
+00:20:32,420 --> 00:20:40,140
+خلال وير كودز and gloves use masks use precaution
+
+237
+00:20:40,140 --> 00:20:46,320
+يوم تستخدم اللي هو و تتحمل ال needles و ال Lancet
+
+238
+00:20:46,320 --> 00:20:50,400
+decontaminate work surfaces with chemical
+
+239
+00:20:50,400 --> 00:20:54,960
+germicides بغسل اليدين and remove protective
+
+240
+00:20:54,960 --> 00:21:00,780
+clothing before leaving the workplace dispose of
+
+241
+00:21:00,780 --> 00:21:04,430
+contaminated material طبعا كلها تعليمات أنتم
+
+242
+00:21:04,430 --> 00:21:08,610
+بتعرفوها avoid contaminating the outside of
+
+243
+00:21:08,610 --> 00:21:15,750
+container target for antiviral therapy بيعطوا علاج
+
+244
+00:21:15,750 --> 00:21:26,590
+ك antiviral بيمنع ال HIV binding and cell entry من
+
+245
+00:21:26,590 --> 00:21:30,370
+خلال اعطائه ماذا هو Soluble recombinant CD4,
+
+246
+00:21:30,990 --> 00:21:38,470
+Dextran Sulfate, Castana, Spermine, Heparin,
+
+247
+00:21:38,690 --> 00:21:45,170
+Soluble Glycoprotein 120 كلها عبارة عن هذه اللي هو
+
+248
+00:21:45,170 --> 00:21:52,190
+علاجات تساعد في منع ارتباط ال HIV بالعيش ودخوله
+
+249
+00:21:52,190 --> 00:21:58,480
+للخلية Reverse transcriptase طبعا هي إلاجات مختلفة
+
+250
+00:21:58,480 --> 00:22:04,140
+بتمنع اللي هو تعمل إجابة للـ Reverse transcriptase
+
+251
+00:22:04,140 --> 00:22:08,840
+في الداخل Resistant
+
+252
+00:22:08,840 --> 00:22:13,740
+strain of HIV too many drugs have emerged عشان هيك
+
+253
+00:22:13,740 --> 00:22:20,460
+بعتوا combination of antiviral drugs عشان يتغلبوا
+
+254
+00:22:20,460 --> 00:22:24,610
+على resistant strain Combined therapy may include
+
+255
+00:22:24,610 --> 00:22:30,650
+highly active antiretroviral therapy for example
+
+256
+00:22:30,650 --> 00:22:33,710
+one protease inhibitor زائد two reverse
+
+257
+00:22:33,710 --> 00:22:36,990
+transcriptase inhibitors أو three reverse
+
+258
+00:22:36,990 --> 00:22:40,350
+transcriptase inhibitors دي كلها combined therapy
+
+259
+00:22:40,350 --> 00:22:48,370
+يوم بيصير فيه resistance لل treatment of HIV ال
+
+260
+00:22:48,370 --> 00:22:52,490
+gene therapy طبعا هو Inhibition of Viral
+
+261
+00:22:52,490 --> 00:22:57,090
+Translation Process Using Antisense Or Nucleotide
+
+262
+00:22:57,090 --> 00:23:03,290
+Or Ribosome Production Of Mutated Protein Which
+
+263
+00:23:03,290 --> 00:23:12,290
+Compete With Original Viral Protein Genetic
+
+264
+00:23:12,290 --> 00:23:16,450
+Manipulation Of Target Cell التي تسمح لهم بالانتقال
+
+265
+00:23:16,450 --> 00:23:18,870
+أو الانتقال من الانتقال من الانتقال من الانتقال من
+
+266
+00:23:18,870 --> 00:23:20,450
+الانتقال من الانتقال من الانتقال من الانتقال من
+
+267
+00:23:20,450 --> 00:23:22,070
+الانتقال من الانتقال من الانتقال من الانتقال من
+
+268
+00:23:22,070 --> 00:23:23,550
+الانتقال من الانتقال من الانتقال من الانتقال من
+
+269
+00:23:23,550 --> 00:23:27,550
+الانتقال من الانتقال من الانتقال من الانتقال من
+
+270
+00:23:27,550 --> 00:23:30,510
+الانتقال من الانتقال من الانتقال من الانتقال من
+
+271
+00:23:30,510 --> 00:23:30,710
+الانتقال من الانتقال من الانتقال من الانتقال من
+
+272
+00:23:30,710 --> 00:23:35,750
+الانتقال من الانتقال من الانتقال من الانتقال من
+
+273
+00:23:35,750 --> 00:23:42,270
+الانتقال من الانتقال من الانتقال من ال
+
+274
+00:23:45,630 --> 00:23:52,730
+اللي هو mutation متعددة سلسلة fusion allow HIV to
+
+275
+00:23:52,730 --> 00:24:00,590
+escape and actually escape anti-HIV latent phase
+
+276
+00:24:00,590 --> 00:24:04,230
+integration into cellular DNA cell-mediated
+
+277
+00:24:04,230 --> 00:24:08,350
+immunity is deficient or delayed lack of animal
+
+278
+00:24:08,350 --> 00:24:15,600
+model زي شامبينزي developed antibody but not الـ
+
+279
+00:24:15,600 --> 00:24:22,280
+AIDS. Anti-HIV antibody may react with CD4 in a
+
+280
+00:24:22,280 --> 00:24:29,540
+similar way to HIV-CD4 interaction. يا سلام! Auto
+
+281
+00:24:29,540 --> 00:24:32,920
+-antibody and immune complexes have harmful effect
+
+282
+00:24:32,920 --> 00:24:37,780
+on many cells.يعني
+
+283
+00:24:37,780 --> 00:24:44,180
+حتى العلاج كمان Auto-antibody ممكن تتكون ويتأثر على
+
+284
+00:24:44,180 --> 00:24:47,980
+أو تعمل immune complexes وتأثر على وتزود الطيب بلى
+
+285
+00:24:47,980 --> 00:24:53,700
+يعني Super infection with HIV with other HIV
+
+286
+00:24:53,700 --> 00:24:59,560
+strains Binding of antibody to GP with 120 is
+
+287
+00:24:59,560 --> 00:25:04,620
+difficult Limited knowledge of mucosal immunity
+
+288
+00:25:04,620 --> 00:25:09,820
+Live attenuated vaccine may revert to virulence
+
+289
+00:25:09,820 --> 00:25:15,700
+New approach أنتيبادي ضد الهيوغو حتى انفجار
+
+290
+00:25:15,700 --> 00:25:21,180
+البروتين يسيطر على التأثير على الهيوغو إضافة CD4
+
+291
+00:25:21,180 --> 00:25:28,800
+جزيئية لسلسلة ممكن تحفز مقاطع الهيوغو الهيوغو
+
+292
+00:25:28,800 --> 00:25:34,780
+يتعامل مع CD4 يمنع الهيوغو من التعامل مع الهيوغو
+
+293
+00:25:34,780 --> 00:25:38,280
+الهيوغو مرتبط بالسلسلة كانت
+
+294
+00:25:38,280 --> 00:25:43,390
+نفحص وقالوا بـ Serological Screening, Antigen
+
+295
+00:25:43,390 --> 00:25:46,870
+Detection, Cell Culturing, and Gene Amplification
+
+296
+00:25:46,870 --> 00:25:54,110
+by PCR ثم بالفلوسيتمتري بنهد الـ CD4 Cell
+
+297
+00:25:54,110 --> 00:25:58,770
+Serological Screening detect circulating Anti-HIV
+
+298
+00:25:58,770 --> 00:26:00,910
+Antibody، Anti-Antibody Reaction
+
+299
+00:26:05,340 --> 00:26:08,780
+يتم اكتشافه من خلال الـ Immunofluorescent Radial
+
+300
+00:26:08,780 --> 00:26:11,640
+Immunoprecipitation تقنية أو الـ Western Blotting
+
+301
+00:26:11,640 --> 00:26:15,800
+وPCR كل
+
+302
+00:26:15,800 --> 00:26:20,140
+هذا ما يتعلق بالإيهاش بالـ HIV Secondary
+
+303
+00:26:20,140 --> 00:26:23,460
+immunodeficiency أيضًا ممكن تدرج نتيجة وجود نيو
+
+304
+00:26:23,460 --> 00:26:29,120
+بلازم أو نظام لينفويد لينفويد لوكيميا لينفوما كمان
+
+305
+00:26:31,340 --> 00:26:37,700
+سجلت حالات كثيرة كسبب من أسباب ال immunodeficiency
+
+306
+00:26:37,700 --> 00:26:42,820
+زي اللوكيميا malignant cells are predominantly in
+
+307
+00:26:42,820 --> 00:26:48,760
+the circulation أو في ال bone marrow بتؤدي إلى قلة
+
+308
+00:26:48,760 --> 00:26:52,560
+في ال immune cells lymphoma برضه بتعمل solid
+
+309
+00:26:52,560 --> 00:26:56,560
+masses في ال lymph nodes في ال spleen في ال thymus
+
+310
+00:26:56,560 --> 00:27:01,180
+في ال extraنهد الأوريجان وهذه كلها مواقع ال
+
+311
+00:27:01,180 --> 00:27:09,140
+response بيلعب دور كبير فيها بيقاتل فيها بعد مرات
+
+312
+00:27:09,140 --> 00:27:12,340
+ال the same malignant cell type can show either
+
+313
+00:27:12,340 --> 00:27:22,240
+presentation للو كيميا و للمفولة في 1996 WHO اقترحت
+
+314
+00:27:22,240 --> 00:27:26,120
+a classification system based on cell of origin
+
+315
+00:27:32,350 --> 00:27:39,630
+PVSTNK and stage of differentiation يعني قسم ال
+
+316
+00:27:39,630 --> 00:27:45,230
+immature precursor versus mature peripheral في
+
+317
+00:27:45,230 --> 00:27:50,810
+تابل إن شاء الله نتطلق له كمان للأسف شديد مالنا
+
+318
+00:27:50,810 --> 00:27:53,290
+تسلقلها the same surface markers
+
+319
+00:27:55,530 --> 00:28:00,590
+لكنها لن تستمر في التطور لأنها ملقنة أما اللي نفسه
+
+320
+00:28:00,590 --> 00:28:04,490
+اللي هي ال cell surface markers هم يتجمدون في عدد
+
+321
+00:28:04,490 --> 00:28:09,370
+كبير ويصبحون من خلال احدى كلون يعني منو كلون أو
+
+322
+00:28:09,370 --> 00:28:13,090
+كلون ويستخدمون
+
+323
+00:28:13,090 --> 00:28:17,890
+نفس الجانب كمقارنة
+
+324
+00:28:17,890 --> 00:28:22,310
+عادية بون مارو لـ immature بيسل ثايمس أو
+
+325
+00:28:29,880 --> 00:28:34,160
+WHO Classification for Lymphoid Malignancy or
+
+326
+00:28:34,160 --> 00:28:42,820
+Neoplasm LB cell B cell proliferation Hodgkin
+
+327
+00:28:42,820 --> 00:28:50,270
+lymphoma Pre-B-Neoplasm من الاسم Pre-B-Lymphoplastic
+
+328
+00:28:50,270 --> 00:28:54,950
+Leukemia أو Lymphoma Pre-B-Acute Lymphoplastic
+
+329
+00:28:54,950 --> 00:29:02,330
+Leukemia كلهم يتجاربون بـ Pro-B, Pre-B أو
+
+330
+00:29:02,330 --> 00:29:08,430
+الانفجارات في مرحلة التطور كما يظهر على صفحة الـ CD
+
+331
+00:29:08,430 --> 00:29:13,270
+على سطح هذه الخلايا. طبعا أيضا يمكن أن تثبت أو
+
+332
+00:29:13,270 --> 00:29:18,450
+تثبت بشكل محدد من اللوكيميا.
+
+333
+00:29:21,290 --> 00:29:26,630
+طبعا هي الصنبي
+
+334
+00:29:26,630 --> 00:29:33,450
+سل نيوبلازم المرتبط بالتعريف من الجنة إلى
+
+335
+00:29:33,450 --> 00:29:37,560
+الكرمزومة Including the immunoglobulin-inhibiting
+
+336
+00:29:37,560 --> 00:29:44,860
+gene on chromosome 14 طبعا ده هو اي بعض ال .. اللي
+
+337
+00:29:44,860 --> 00:29:50,940
+هو PCL2 يجي على منطقة ده و chromosome 14 منطقة ال
+
+338
+00:29:50,940 --> 00:29:55,260
+-inhibiting gene rearrangement ماشي و هجمها طبعا
+
+339
+00:29:55,260 --> 00:29:58,620
+هاي another mutation CMEC اللي هو وجودها
+
+340
+00:29:58,620 --> 00:30:03,850
+chromosome رقم 18 و هي PCL1 ايضا كلهم بلعبوه أو
+
+341
+00:30:03,850 --> 00:30:08,070
+بيشتغلوا على هذه المنطقة اللي هي على كرمزوم 14
+
+342
+00:30:08,070 --> 00:30:12,110
+وبالتالي بيعملوا خلل في ال immunoglobulin gene،
+
+343
+00:30:12,110 --> 00:30:16,230
+heavy-chain gene rearrangement فيوسمك بيعمل
+
+344
+00:30:16,230 --> 00:30:21,010
+Burkitt lymphoma و ال PCL1 بيعمل mantle zone
+
+345
+00:30:21,010 --> 00:30:24,970
+lymphopenia بينما ال PCL2 بيعمل follicular
+
+346
+00:30:24,970 --> 00:30:25,790
+lymphoma
+
+347
+00:30:28,000 --> 00:30:32,060
+بالإضافة إلى الـ Blast أو الـ Stem Cell Marker
+
+348
+00:30:32,060 --> 00:30:39,800
+CD34 يمكن أن تظهر CD10 أو CD19 كمعنى كمعنى كمعنى
+
+349
+00:30:39,800 --> 00:30:41,500
+كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى
+
+350
+00:30:41,500 --> 00:30:43,640
+كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى
+
+351
+00:30:43,640 --> 00:30:43,680
+كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى
+
+352
+00:30:43,680 --> 00:30:44,920
+كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى كمعنى
+
+353
+00:30:44,920 --> 00:30:49,560
+كمعنى كمعنى كمعنى ك
+
+354
+00:30:51,120 --> 00:30:57,740
+وهذا الانزيم عادةً يتطلب تجارب الجنة في مراحل
+
+355
+00:30:57,740 --> 00:31:05,660
+مبكرة جدا أو TCR تجارب الجنة كيمافترابيا كانت
+
+356
+00:31:05,660 --> 00:31:11,220
+مفهومة في التعامل بالأطفال مع هذه اللوكيميا بيركتس
+
+357
+00:31:11,220 --> 00:31:15,640
+لينفومة اللوكيميا طبعاً مخصصة من التعامل
+
+358
+00:31:18,610 --> 00:31:24,110
+من خلال الـ Myc Oncogene وتدخله في الـ
+
+359
+00:31:24,110 --> 00:31:26,690
+Immunoglobulin heavy chain gene في هذا ال area
+
+360
+00:31:26,690 --> 00:31:35,190
+سواء كان في ال heavy chain أو في ال two light
+
+361
+00:31:35,190 --> 00:31:40,590
+chains في جين اللي هو
+
+362
+00:31:43,930 --> 00:31:49,250
+Translocation 8.14 أو Translocation 8.22 أو
+
+363
+00:31:49,250 --> 00:31:53,590
+Translocation 2.8 كلها عبارة عن Translocation
+
+364
+00:31:53,590 --> 00:31:58,350
+Myc روتين أيضا بنشط الجينات for cell
+
+365
+00:31:58,350 --> 00:32:01,370
+proliferation و Translocation to Immunoglobulin
+
+366
+00:32:01,370 --> 00:32:04,650
+gene بيؤدي إلى زيادة ال expression of C-Myc و
+
+367
+00:32:04,650 --> 00:32:09,730
+Increase cell proliferation. In equatorial Africa,
+
+368
+00:32:11,150 --> 00:32:13,790
+this lymphoma is endemic and is associated with a
+
+369
+00:32:13,790 --> 00:32:18,650
+Epstein-Barr virus or B cell lymphoma. البركز
+
+370
+00:32:18,650 --> 00:32:21,210
+ليمفومة هو واحد من الماليجنانسي اللي بتشوف في
+
+371
+00:32:21,210 --> 00:32:25,870
+immunosuppression للمرضى in which a Epstein-Barr
+
+372
+00:32:25,870 --> 00:32:30,660
+virus genome is also sometimes found in the لنفومة
+
+373
+00:32:30,660 --> 00:32:35,240
+المعتقلة follicular lymphoma الاسم follicular ت
+
+374
+00:32:35,240 --> 00:32:38,780
+represent transformation of B cells اللي موجودة
+
+375
+00:32:38,780 --> 00:32:42,100
+normally in lymph node follicles في ال follicular 
+
+376
+00:32:42,100 --> 00:32:46,340
+BCL2 lymphoma هو اللي شغال، وشو بيعمل؟ أيضا
+
+377
+00:32:46,340 --> 00:32:50,540
+يتدخل في الـ immunoglobulin inhibit chain gene وهذا
+
+378
+00:32:50,540 --> 00:32:54,320
+بيؤدي إلى continuous expression of BCL2
+
+379
+00:32:56,900 --> 00:33:02,520
+الذي يمنع الموت من الـ Mantle cell lymphoma
+
+380
+00:33:02,520 --> 00:33:08,840
+التحتاني اللي هو برضه قد دور الـ PCA الواحد مش
+
+381
+00:33:08,840 --> 00:33:12,780
+الـ PCA الاتنين اللي بلعب دور كبير برضه وبرانيو
+
+382
+00:33:12,780 --> 00:33:16,490
+بلازم of this mantle cell تشهد بشكل نفسي بـ Cell
+
+383
+00:33:16,490 --> 00:33:19,150
+Phenotype كما يحدث أيضًا للمشاركات الطبيعية الـ
+
+384
+00:33:19,150 --> 00:33:24,610
+C19-25 and Surface Immunoglobulin زي ما قلنا
+
+385
+00:33:24,610 --> 00:33:32,810
+الـ PCL-1 بلعب دوري كبير في الجينات في إحداث الـ
+
+386
+00:33:32,810 --> 00:33:40,500
+Translocation ما بين 11 و14 It has higher سرعة
+
+387
+00:33:40,500 --> 00:33:45,560
+مفتوحة وشركات أكثر عضوية من اللنفومة الفوليكيلارية
+
+388
+00:33:45,560 --> 00:33:53,120
+مقارنة اللنفومة ليش
+
+389
+00:33:53,120 --> 00:33:57,720
+طبعا associated with مرض ليه ميكوزر associated
+
+390
+00:33:57,720 --> 00:34:02,820
+lymphoid tissue أيضا maybe associated with chronic
+
+391
+00:34:02,820 --> 00:34:07,110
+antigenic stimulation أو autoimmune disease على
+
+392
+00:34:07,110 --> 00:34:09,610
+سبيل المثال الهيليكوباكتر الهيليكوفاكتر
+
+393
+00:34:09,610 --> 00:34:09,870
+الهيليكوفاكتر الهيليكوفاكتر الهيليكوفاكتر
+
+394
+00:34:09,870 --> 00:34:12,690
+الهيليكوفاكتر الهيليكوفاكتر الهيليكوفاكتر
+
+395
+00:34:12,690 --> 00:34:14,550
+الهيليكوفاكتر الهيليكوفاكتر الهيليكوفاكتر
+
+396
+00:34:14,550 --> 00:34:17,690
+الهيليكوفاكتر الهيليكوفاكتر الهيليكوفاكتر
+
+397
+00:34:17,690 --> 00:34:18,970
+الهيليكوفاكتر الهيليكوفاكتر الهيليكوفاكتر
+
+398
+00:34:18,970 --> 00:34:25,570
+الهيليكوفاكتر الهيليكوفاكتر الهيليكوفاكتر
+
+399
+00:34:25,570 --> 00:34:28,890
+الهيليكوفاكتر
+
+400
+00:34:28,890 --> 00:34:34,410
+الهيليكوفاكتر و دايدس الواجهة اللي بيصير high
+
+401
+00:34:34,410 --> 00:34:39,390
+incidence of this B cell lymphoma Chronic
+
+402
+00:34:39,390 --> 00:34:44,950
+antigenic stimulation بيقدّي إلى fertile group for
+
+403
+00:34:44,950 --> 00:34:49,150
+the development of B cell lymphoma طبعا B cell
+
+404
+00:34:49,150 --> 00:34:52,850
+بتستمر في إحداث somatic mutation في immunoglobulin
+
+405
+00:34:52,850 --> 00:35:00,030
+gene أيضا سجلوا defect in the regulation of B cell
+
+406
+00:35:00,970 --> 00:35:04,570
+بسبب نقل من تسل تسل تسل تسل تسل تسل تسل تسل تسل
+
+407
+00:35:04,570 --> 00:35:13,350
+تسل تسل تسل تسل تسل تسل تسل تسل تسل تسل تسل تسل
+
+408
+00:35:13,350 --> 00:35:16,170
+تسل تسل تسل تسل تسل تسل تسل تسل تسل تسل تسل تسل
+
+409
+00:35:16,170 --> 00:35:22,310
+تسل تسل تسل
+
+410
+00:35:22,310 --> 00:35:28,550
+ت
+
+411
+00:35:30,050 --> 00:35:35,490
+أمريكان و Western Europe تسبب الاختيارية الوضع
+
+412
+00:35:35,490 --> 00:35:41,510
+الوضع الوضع
+
+413
+00:35:41,510 --> 00:35:44,870
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+414
+00:35:44,870 --> 00:35:45,730
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+415
+00:35:45,730 --> 00:35:45,770
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+416
+00:35:45,770 --> 00:35:50,030
+الوضع الوضع الوضع الوضع الوضع الوضع الوضع
+
+417
+00:35:50,030 --> 00:35:52,870
+الوضع الوضع
+
+418
+00:35:56,520 --> 00:36:03,440
+من الاسم plasma-cytoma وطبعا it's also called
+
+419
+00:36:03,440 --> 00:36:10,160
+multiple myeloma or plasma cell myeloma Tile 6
+
+420
+00:36:10,160 --> 00:36:13,960
+function as a autocrine growth factor for myeloma
+
+421
+00:36:13,960 --> 00:36:19,800
+cell فطبعا النيو بلاستيك في الـ multiple myeloma
+
+422
+00:36:19,800 --> 00:36:27,040
+بيتتصنع monoclonal immunoglobulin أو بروتين زي الـ
+
+423
+00:36:27,040 --> 00:36:30,080
+Benzoyl Protein اللي عبارة عن Light Immunoglobulin
+
+424
+00:36:30,080 --> 00:36:36,840
+Chain اللي يمر في الـ Urine وطبعا هذه ممكن تكون
+
+425
+00:36:36,840 --> 00:36:40,620
+Amyloid اللي يمكن أن يسبب فيها خطأ أورجام خاصة في
+
+426
+00:36:40,620 --> 00:36:45,040
+الجدن Limphoplasmicytic
+
+427
+00:36:45,040 --> 00:36:49,120
+Lymphoma أو
+
+428
+00:36:49,120 --> 00:36:52,820
+ما تسمى بالـ Waldenstrom Macroglobulinemia
+
+429
+00:36:55,160 --> 00:37:00,900
+طبعا هنا بـ Lymphocytes بتصنع لنا IgM كل اللي صار
+
+430
+00:37:00,900 --> 00:37:05,200
+أنها فشلت الخلية في أن تنتقل من الـ B-cell إلى
+
+431
+00:37:05,200 --> 00:37:13,960
+الـ plasma cell فبتجه في النص المرحلة وبتعمل ..
+
+432
+00:37:13,960 --> 00:37:18,780
+بنشوف خلية بسموها lymphoplasmic cytoid أو plasma
+
+433
+00:37:18,780 --> 00:37:24,320
+cytomus بيصير فيه over production الـ IGM وهذا بيعمل
+
+434
+00:37:24,320 --> 00:37:32,020
+hyperviscosity وايضا circulating problem is done
+
+435
+00:37:32,020 --> 00:37:36,720
+لأنه فيه hyperviscosity خصوصا في الـ extremities زي
+
+436
+00:37:36,720 --> 00:37:43,220
+الـ fingers و الـ toys تيسل ميوبلازم precursor تيسل
+
+437
+00:37:43,220 --> 00:37:48,620
+acute lymphoblastic leukemia it has characteristic
+
+438
+00:37:48,620 --> 00:37:57,130
+identity الذين كانوا مفجرين في موقعهم الانفجار تي
+
+439
+00:37:57,130 --> 00:38:00,450
+أكيوت لينفو بلاستيك لو كيميا اكسبرس بان تي سيل
+
+440
+00:38:00,450 --> 00:38:07,350
+ماركات زي cd2 و5 و7 و تي أكيوت لينفو بلاستيك لو
+
+441
+00:38:07,350 --> 00:38:08,930
+كيميا تي سيل ماركات زي cd2 و5 و7 و تي أكيوت لينفو
+
+442
+00:38:08,930 --> 00:38:12,610
+بلاستيك لو كيميا تي سيل ماركات زي cd2 و5 و7 و تي
+
+443
+00:38:12,610 --> 00:38:15,130
+أكيوت لينفو بلاستيك لو كيميا تي سيل ماركات زي cd2
+
+444
+00:38:15,130 --> 00:38:18,630
+و5 و7 و تي أكيوت لينفو بلاستيك لو كيميا تي سيل
+
+445
+00:38:18,630 --> 00:38:23,680
+ماركات زي cd2 و5 و7 و تي أكيوت لينفو بلا T تمثل
+
+446
+00:38:23,680 --> 00:38:33,160
+اللوكيميا أو كمزة ثائمية أفضل تي سيل بيو بلازم هذي
+
+447
+00:38:33,160 --> 00:38:37,960
+أكثر من
+
+448
+00:38:37,960 --> 00:38:44,340
+بي سيل لوفرومة في منها كيتينوس تيسل لينفوما بيصير
+
+449
+00:38:44,340 --> 00:38:49,120
+infiltration to the epidermis with malignant CD4 T
+
+450
+00:38:49,120 --> 00:38:54,280
+cell وطبعا هذا بيقدي للانتشار في الـ lymph nodes
+
+451
+00:38:54,280 --> 00:38:58,780
+and even into the blood الماليجنان
+
+452
+00:38:58,780 --> 00:39:02,280
+تيسل أيضا found in the circulation are called
+
+453
+00:39:02,280 --> 00:39:06,500
+cesarean cell والسندروم بيسموه cesarean syndrome
+
+454
+00:39:07,920 --> 00:39:12,780
+اضالة T-cell أكيد لنفوذ T لنفوذ بلاستيك لوكيميا أو
+
+455
+00:39:12,780 --> 00:39:22,520
+لنفومة It's an aggressive disease and it's new
+
+456
+00:39:22,520 --> 00:39:27,460
+plasma of mature CD4 T cell IL2 بلعب دورة as
+
+457
+00:39:27,460 --> 00:39:32,120
+autocrine growth factor for these cells It's
+
+458
+00:39:32,120 --> 00:39:35,720
+caused by retrovirus human T cell lymphotropic
+
+459
+00:39:35,720 --> 00:39:43,680
+virus 1 التي تم تسميتها وإزالتها قبل إعادة الـ AIDS
+
+460
+00:39:43,680 --> 00:39:51,380
+والـ HIV التنمية متشابهة إلى الـ HIV تدخل في عامين
+
+461
+00:39:51,380 --> 00:39:52,660
+من عامين من عامين من عامين من عامين من عامين من
+
+462
+00:39:52,660 --> 00:39:53,140
+عامين من عامين من عامين من عامين من عامين من عامين
+
+463
+00:39:53,140 --> 00:39:54,980
+من عامين من عامين من عامين من عامين من عامين من
+
+464
+00:39:54,980 --> 00:39:57,340
+عامين من عامين من عامين من عامين من عامين من عامين
+
+465
+00:39:57,340 --> 00:39:59,880
+من عامين من عامين من عامين من عامين من عامين من
+
+466
+00:39:59,880 --> 00:40:03,160
+عامين من عامين من عامين من عامين من عامين من عامين
+
+467
+00:40:03,620 --> 00:40:09,820
+ATL-L CD4 T-cells harbor the virus in quiescent
+
+468
+00:40:09,820 --> 00:40:17,040
+state it's not cytolytic Hodgkin lymphoma طبعا
+
+469
+00:40:17,040 --> 00:40:22,660
+بتشتهر بوجود خلية مميزة هي رباعية nucleated
+
+470
+00:40:22,660 --> 00:40:30,040
+malignant cell بيسموها Reed-Sternberg cells وبتشبه
+
+471
+00:40:30,040 --> 00:40:40,010
+اللي هو أتخارية كبيرة فيها تونيوكلياس غالبا و it's
+
+472
+00:40:40,010 --> 00:40:44,770
+usually a reactive background بتمثل reactive
+
+473
+00:40:44,770 --> 00:40:49,570
+background أو multicell زينوفيل بلازمة يعني موجودة
+
+474
+00:40:49,570 --> 00:40:57,010
+في في في tissue infiltrated with many cell منها
+
+475
+00:40:57,010 --> 00:41:01,450
+multicell زينوفيل بلازمة cell macrophages and
+
+476
+00:41:01,450 --> 00:41:02,490
+fibrotic tissue
+
+477
+00:41:05,270 --> 00:41:10,510
+بتنتج IL-5 بيه tumor cell and or background cell
+
+478
+00:41:10,510 --> 00:41:14,810
+طبعا
+
+479
+00:41:14,810 --> 00:41:17,790
+الـ patient عندهم fever , night sweating و weight
+
+480
+00:41:17,790 --> 00:41:25,370
+loss و recent study using molecular technique have
+
+481
+00:41:25,370 --> 00:41:27,650
+shown rearrangement of immunoglobulin gene
+
+482
+00:41:27,650 --> 00:41:32,470
+suggesting that they are of B cell origin however
+
+483
+00:41:32,870 --> 00:41:35,550
+هذه اللمفومة تتعامل بشكل مختلف عن اللمفومة الكبيرة
+
+484
+00:41:35,550 --> 00:41:41,290
+بيسا ومن هناك تبقى مقارنة بشكل مختلف اللمفومة
+
+485
+00:41:41,290 --> 00:41:44,950
+تتعامل بشكل مختلف عن اللمفومة الهودجكينية ومع
+
+486
+00:41:44,950 --> 00:41:46,290
+اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس
+
+487
+00:41:46,290 --> 00:41:50,990
+هودجكينية ومع
+
+488
+00:41:50,990 --> 00:41:51,650
+اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس
+
+489
+00:41:51,650 --> 00:41:53,290
+هودجكينية ومع اللمفومة اللي ليس هودجكينية و
diff --git a/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/k6fYGUa0Alk_raw.json b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/k6fYGUa0Alk_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..4ee583369dcfc4fa868bb10dd72c22ca9170fcaa
--- /dev/null
+++ b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/k6fYGUa0Alk_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2304, "start": 3.76, "end": 23.04, "text": "بسم الله الرحمن الرحيم نلتقي الآن في تكملة جزء تاني من المحاضرة والتي هي بعنوان immunodeficiency شرحنا في المحاضرة الأولى ال primary immunodeficiency disease واليوم ان شاء الله هنحكي على ال secondary immunodeficiency", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 8717, 1211, 2655, 38436, 6024, 48506, 8978, 6055, 24793, 37977, 10874, 11622, 38207, 6055, 7649, 1829, 9154, 9673, 5016, 46958, 25720, 16070, 31371, 39896, 45030, 1863, 2407, 7649, 13154, 1429, 1786, 7848, 13412, 2288, 5016, 8315, 8978, 9673, 5016, 46958, 25720, 16247, 12610, 7578, 2423, 6194, 13154, 1429, 1786, 7848, 4752, 16070, 1829, 20498, 16472, 13412, 16606, 21984, 8032, 1863, 5016, 4117, 1829, 15844, 2423, 11396, 13154, 1429, 1786, 7848], "avg_logprob": -0.16767577677965165, "compression_ratio": 1.7407407407407407, "no_speech_prob": 7.748603820800781e-07, "words": [{"start": 3.76, "end": 4.04, "word": "بسم", 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"start": 2492.87, "end": 2513.29, "text": "هذه اللمفومة تتعامل بشكل مختلف عن اللمفومة الكبيرة بيسا ومن هناك تبقى مقارنة بشكل مختلف اللمفومة تتعامل بشكل مختلف عن اللمفومة الهودجكينية ومع اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس هودجكينية ومع اللمفومة اللي ليس هودجكينية و", "tokens": [3224, 24192, 13672, 2304, 5172, 20498, 3660, 6055, 2655, 3615, 10943, 1211, 4724, 8592, 28820, 3714, 46456, 46538, 18871, 13672, 2304, 5172, 20498, 3660, 33251, 3555, 48923, 4724, 1829, 3794, 995, 4032, 27842, 34105, 4117, 6055, 3555, 4587, 7578, 3714, 4587, 9640, 1863, 3660, 4724, 8592, 28820, 3714, 46456, 46538, 13672, 2304, 5172, 20498, 3660, 6055, 2655, 3615, 10943, 1211, 4724, 8592, 28820, 3714, 46456, 46538, 18871, 13672, 2304, 5172, 20498, 3660, 2423, 3224, 23328, 7435, 4117, 9957, 10632, 4032, 2304, 3615, 13672, 2304, 5172, 20498, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/vqUjT-Vann4.srt b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/vqUjT-Vann4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..22140cda0dc319e3cc8421ab63a8d766c1e7d03b
--- /dev/null
+++ b/PL9fwy3NUQKwYQ8nzyth9nyErvTJtUFKlo/vqUjT-Vann4.srt
@@ -0,0 +1,2579 @@
+1
+00:00:08,120 --> 00:00:12,240
+نلتقي اليوم في محاضرة جديدة بعنوان MHC gene and 
+
+2
+00:00:12,240 --> 00:00:18,320
+products.  الـ MHC gene ما عبارة عن جينات موجودين على 
+
+3
+00:00:18,320 --> 00:00:23,460
+كروموسوم رقم ستة in a human and they are called HLA
+
+4
+00:00:23,460 --> 00:00:27,980
+human leukocyte antigen. وما عبارة عن نوعين MHC 
+
+5
+00:00:27,980 --> 00:00:34,830
+class 1. هو ثلاثة أنواع لكن هؤلاء اللي مرتبطين 
+
+6
+00:00:34,830 --> 00:00:38,450
+بأنتجين
+
+7
+00:00:38,450 --> 00:00:46,990
+وأنـتـجين وأنـتـجين وأنـتـجين
+
+8
+00:00:46,990 --> 00:00:53,470
+أنتجين أنتجين أنتجين أنتجين أنتجين أنتجين أنتجين
+
+9
+00:00:53,470 --> 00:00:57,550
+أنتجين أنتجين
+
+10
+00:00:57,550 --> 00:00:58,270
+أنتجين أنتجين أنتجين أنتجين أنتجين أنتجين أنتجين
+
+11
+00:00:58,270 --> 00:00:58,290
+أنتجين أنتجين أنتجين أنتجين أنتجين أنتجين أنتجين
+
+12
+00:00:58,290 --> 00:01:03,660
+أنتجين أنتجين. وهنا فينا ثلاثة individual genes for
+
+13
+00:01:03,660 --> 00:01:09,520
+class 1، وثلاثة individual sets of genes أيضًا for
+
+14
+00:01:09,520 --> 00:01:19,180
+class 2. class 1 بيسموهم HLA A وB وC بينما class 2 
+
+15
+00:01:19,180 --> 00:01:27,740
+بيسموه HLA DB DQ DR. الـ
+
+16
+00:01:33,600 --> 00:01:40,300
+Each MHC class subregion طبعًا they are present on
+
+17
+00:01:40,300 --> 00:01:46,700
+كروموسوم رقم ستة in three different regions. دي الـ
+
+18
+00:01:46,700 --> 00:01:52,860
+regions A وB وC وD. four different regions وفي هنا 
+
+19
+00:01:52,860 --> 00:01:57,000
+subregions. الـ subregion تحتوي على في class two MHC
+
+20
+00:01:57,000 --> 00:02:04,540
+class two تحتوي على A or and B genes that they code
+
+21
+00:02:04,540 --> 00:02:12,800
+for alpha or beta اللي هو chain respectively على 
+
+22
+00:02:12,800 --> 00:02:23,000
+سبيل المثال الـ HLA-DBA gene codes for DB alpha و
+
+23
+00:02:23,000 --> 00:02:25,740
+الـ HLA-DB molecule.
+
+24
+00:02:33,320 --> 00:02:39,560
+أيضًا code for DBE بيتا. هنشوفه إن شاء الله في صورة
+
+25
+00:02:39,560 --> 00:02:45,520
+واضحة بشكل أفضل. The
+
+26
+00:02:45,520 --> 00:02:53,620
+two chain molecule هي DQ α بيتا DQ α بيتا و DR α 
+
+27
+00:02:53,620 --> 00:02:59,720
+بيتا. نفس الحكاية ما انطبق على الـ DB انطبق بأنطبق 
+
+28
+00:02:59,720 --> 00:03:05,240
+على DQ و DR. في عندهم Alpha و Beta كل واحد كل واحد
+
+29
+00:03:05,240 --> 00:03:12,240
+أو كل جين مسؤول عن DB DQ او R بـ code for two bullet
+
+30
+00:03:12,240 --> 00:03:16,440
+بتاعة الـ chain اللي Alpha و Beta. MLC Class I
+
+31
+00:03:16,440 --> 00:03:21,340
+molecule موجودة على كل خلية خلال المخلوق المخلوق
+
+32
+00:03:21,340 --> 00:03:23,620
+المخلوق المخلوق المخلوق المخلوق المخلوق المخلوق
+
+33
+00:03:23,620 --> 00:03:23,720
+المخلوق المخلوق المخلوق المخلوق المخلوق المخلوق
+
+34
+00:03:23,720 --> 00:03:24,040
+المخلوق المخلوق المخلوق المخلوق المخلوق المخلوق
+
+35
+00:03:24,040 --> 00:03:25,660
+المخلوق المخلوق المخلوق المخلوق المخلوق المخلوق
+
+36
+00:03:25,660 --> 00:03:28,380
+المخلوق المخلوق المخلوق المخلوق المخلوق المخلوق
+
+37
+00:03:28,380 --> 00:03:34,440
+المخلوق المخلوق المخلوق المخلوق المخلوق المخلوق
+
+38
+00:03:34,440 --> 00:03:35,340
+المخلوق المخلوق المخلوق المخلوق المخلوق المخلوق
+
+39
+00:03:35,340 --> 00:03:43,020
+المخلوق
+
+40
+00:03:43,780 --> 00:03:46,940
+بينما class 2 موجودة على الـ antigen presenting cell
+
+41
+00:03:46,940 --> 00:03:52,280
+و it's limited to certain cells. it's limited to
+
+42
+00:03:52,280 --> 00:03:58,380
+certain cells expression. expression of MSC class 1
+
+43
+00:03:58,380 --> 00:04:05,450
+is coordinated. يعني التلاتة كل التلاتة MHC class one
+
+44
+00:04:05,450 --> 00:04:07,910
+molecules are expressed on the surface of the cell
+
+45
+00:04:07,910 --> 00:04:11,810
+at the same time. تلاتة they are inherited
+
+46
+00:04:11,810 --> 00:04:16,370
+expression. their expression together. they are
+
+47
+00:04:16,370 --> 00:04:20,050
+coordinated أيضًا.
+
+48
+00:04:20,050 --> 00:04:26,630
+الـ MHC class two is expressed coordinately. لكن في
+
+49
+00:04:26,630 --> 00:04:30,870
+شوية regulation. class واحد يمكن أن يتم إدراجه في
+
+50
+00:04:30,870 --> 00:04:36,830
+مفاوضة أي MHC Class 2. طبيعي جدًا هذا يسمى إدراج
+
+51
+00:04:36,830 --> 00:04:42,110
+وهذا يسمى إدراج لوحده لأن هذا موجود على خلايا
+
+52
+00:04:42,110 --> 00:04:46,450
+وهذا موجود على خلايا مستوى MHC Class 1 و2. إدراج
+
+53
+00:04:46,450 --> 00:04:53,770
+على سطح الخلايا يمكن أن يتم إدراجه أو يتم إدراجه
+
+54
+00:04:53,770 --> 00:04:54,310
+أو يتم إدراجه أو يتم إدراجه أو يتم إدراجه أو يتم
+
+55
+00:04:54,310 --> 00:04:55,090
+إدراجه أو يتم إدراجه أو يتم إدراجه أو يتم إدراجه
+
+56
+00:04:55,090 --> 00:04:56,250
+أو يتم إدراجه أو يتم إدراجه أو يتم إدراجه أو يتم
+
+57
+00:04:56,250 --> 00:04:58,830
+إدراجه أو يتم إدراجه أو يتم إدراجه أو يتم إدراجه
+
+58
+00:04:58,830 --> 00:05:01,750
+أو يتم  Enhance the expression of class 2 among C
+
+59
+00:05:01,750 --> 00:05:09,470
+molecules and class 1. وهذه 
+
+60
+00:05:09,470 --> 00:05:16,410
+الصورة موضحة تمامًا وهي class 1 موجود على أية من 
+
+61
+00:05:16,410 --> 00:05:24,010
+ثلاثة أنواع A وB وC. وهي class 2 أيضًا موجود على اللي
+
+62
+00:05:24,010 --> 00:05:33,760
+هو الـ D region ويقسمون إلى DB وDQ وDR. ويهان كل جين
+
+63
+00:05:33,760 --> 00:05:41,540
+مسؤول عن الـA أو الـB أو الـC. code for Alpha
+
+64
+00:05:41,540 --> 00:05:48,120
+polypeptide gene فقط. وفي مكان آخر بيتصنع الـBeta 2
+
+65
+00:05:48,120 --> 00:05:52,040
+-microglobulin اللي بيشبك في الـAlpha وبيدينا
+
+66
+00:05:52,040 --> 00:05:58,700
+MHC class I موليكيول. هي عبارة عن ثلاثة alpha ثلاثة
+
+67
+00:05:58,700 --> 00:06:04,280
+domains of alpha مرتبطين بال beta 2 microglobulin. وما
+
+68
+00:06:04,280 --> 00:06:10,880
+ينطبق على الـ a ينطبق على الـ b و الـ c. بينما class 2
+
+69
+00:06:10,880 --> 00:06:14,160
+MHC موليكيول إنـها دي دي دي دي دي دي دي دي دي دي دي
+
+70
+00:06:14,160 --> 00:06:15,900
+دي دي دي دي دي دي دي دي دي دي
+
+71
+00:06:24,140 --> 00:06:29,480
+أما Alpha و Beta. طبعًا هنا في Alpha و Beta و Alpha
+
+72
+00:06:29,480 --> 00:06:32,460
+و Beta و Alpha و Beta في التلاتة فالتانية التلاتة
+
+73
+00:06:32,460 --> 00:06:37,420
+طبعًا they are expressed on the surface as Alpha و
+
+74
+00:06:37,420 --> 00:06:41,300
+Beta. لكن Alpha وجدوا أنه في لها two domains. Alpha 1
+
+75
+00:06:41,300 --> 00:06:44,820
+و Alpha 2 و Beta لها أيضًا two domains. Beta 1 و Beta
+
+76
+00:06:44,820 --> 00:06:48,700
+2. فبالتالي الـ structure of class 2 في جميع الأحوال
+
+77
+00:06:48,700 --> 00:06:51,060
+Alpha 1 و Alpha 2 و Beta 1 و Beta 2.
+
+78
+00:06:55,440 --> 00:07:03,920
+وهي الـ class one MHC molecule زي ما أنتم شايفين 
+
+79
+00:07:03,920 --> 00:07:10,160
+بيتكون من one polypeptide chain لكنها عبارة عن
+
+80
+00:07:10,160 --> 00:07:13,760
+three different domains. Alpha one, Alpha two, Alpha
+
+81
+00:07:13,760 --> 00:07:18,220
+three. مرتبطين بمين؟ بالـ beta two microglobulin.
+
+82
+00:07:18,220 --> 00:07:23,380
+مرتبطين non-covalently بمين؟ بالـ beta two 
+
+83
+00:07:23,380 --> 00:07:29,700
+microglobulin. لأ الـ alpha domain is connected to
+
+84
+00:07:29,700 --> 00:07:31,920
+each other by the disulfide bond. ونفس الحكاية الـ
+
+85
+00:07:31,920 --> 00:07:38,840
+beta2 microglobulin intra-disulfide bond. الـ
+
+86
+00:07:38,840 --> 00:07:47,400
+domains of alpha. ماشي.
+
+87
+00:07:47,400 --> 00:07:51,200
+موجود إن الـ alpha 1 و الـ alpha 2 are external
+
+88
+00:07:51,200 --> 00:07:57,930
+domains and they are variable. They are invariable
+
+89
+00:07:57,930 --> 00:08:04,210
+يعني انفرادتشين وبالتالي هم من يحددوا الـ
+
+90
+00:08:04,210 --> 00:08:07,250
+variability أو الـ specificity. وبعملش class one
+
+91
+00:08:07,250 --> 00:08:17,150
+molecule. وفيها الـ groove التجويف which bind to the
+
+92
+00:08:17,150 --> 00:08:21,730
+peptide. ماشي. وزي ما أنتم شايفين الـ groove is
+
+93
+00:08:21,730 --> 00:08:26,900
+closed. ماشي. وهذه نقطة مهمة لأنه بما أنه closed يبقى
+
+94
+00:08:26,900 --> 00:08:33,660
+ما أقدرش يستوعب بيبتايد بحجم كبير. فارتباط البيبتايد
+
+95
+00:08:33,660 --> 00:08:38,620
+بيكون هان واللي فوق عبارة عن إيش؟ الـ variable Alpha
+
+96
+00:08:38,620 --> 00:08:43,840
+3 Beta 2 Microglobulin بيشكلوا أو بيمثلوا الـ
+
+97
+00:08:43,840 --> 00:08:53,570
+constant domain. وفي Alpha 3 بيرتبط الـ CD8 بينما الـ 
+
+98
+00:08:53,570 --> 00:08:57,230
+Antigen ده هو اللي موجود في الـ Groove بيرتبط في
+
+99
+00:08:57,230 --> 00:09:00,950
+الـ TCR. وهذه واضحة صورة موضحة. هاي الـ Peptide
+
+100
+00:09:00,950 --> 00:09:07,470
+وموجود ده بين Alpha 1 و Alpha 2. وزي ما أنتم 
+
+101
+00:09:07,470 --> 00:09:12,210
+شايفين الـ Groove بيحمل Peptide لها تجاوز حجمها 8
+
+102
+00:09:12,210 --> 00:09:17,710
+إلى 9 Amino Acids. وهذه بتقدم إلى الـ TCR. من يرتبط 
+
+103
+00:09:17,710 --> 00:09:23,070
+بها الـ TCR. لكن Alpha-3 بترتبط بمين؟ بالـ Co
+
+104
+00:09:23,070 --> 00:09:29,270
+-Receptor. سميناه CDH CD8 لأنه MHC Class I ملكيوري
+
+105
+00:09:29,270 --> 00:09:40,370
+بيقدم الـ antigen لمين؟ لـ CD8 Alpha.
+
+106
+00:09:40,370 --> 00:09:49,930
+Class II MHC ملكيوري هم برضه بيتكون من طوب الـ
+
+107
+00:09:49,930 --> 00:09:55,310
+peptide chain Alpha وBeta. وكل واحدة منهم فيها two
+
+108
+00:09:55,310 --> 00:09:58,570
+domains. ففيها Alpha 1 وAlpha 2 وBeta 1 وBeta 2
+
+109
+00:09:58,570 --> 00:10:03,450
+ويعني برضه منقسمين إلى الـ variable و constant
+
+110
+00:10:03,450 --> 00:10:07,170
+region. فالـ variable بتشكل Alpha 1 وBeta 1 وفيها الـ
+
+111
+00:10:07,170 --> 00:10:15,330
+groove. وفيها الـ pocket اللي بيرتبط بالـ بيبتايد 
+
+112
+00:10:15,330 --> 00:10:24,730
+antigenic peptide. وزمتوا شايفين الـ peptide هنا is
+
+113
+00:10:24,730 --> 00:10:30,550
+open. الـ groove is open وبالتالي يستطيع إنه يحمل أو
+
+114
+00:10:30,550 --> 00:10:37,610
+يرتبط الـ peptide أكبر حجمًا. يبقى اللي فوق عبارة عن
+
+115
+00:10:37,610 --> 00:10:41,390
+variable Alpha 2 و Beta 2. دولة بشكل الـ constant
+
+116
+00:10:41,390 --> 00:10:50,350
+region. أيضًا الـ CD4 بيرتبط بالـ Beta 2. CD4 بيرتبط 
+
+117
+00:10:50,350 --> 00:10:54,330
+بالـ Beta 2. شايفين بيبتعد حجم من 12 ل 20 amino
+
+118
+00:10:54,330 --> 00:11:00,170
+acids. يعني حجم كبير. و TCR ده هو بيرتبط بمين؟ بالـ
+
+119
+00:11:00,170 --> 00:11:04,730
+MHC Class 2 موليكيول بالـ antigen اللي ممسوك بالـ MHC
+
+120
+00:11:04,730 --> 00:11:11,170
+Class 2 موليكيول. الـ variability of MHC gene and
+
+121
+00:11:11,170 --> 00:11:11,650
+product.
+
+122
+00:11:14,980 --> 00:11:19,880
+الـ Genetic Polymorphism. وجدوا أنه فيه Different 
+
+123
+00:11:19,880 --> 00:11:23,040
+Alleles
+
+124
+00:11:23,040 --> 00:11:33,980
+ماشي. Presence in each MHC Class I أو Class II وهذا
+
+125
+00:11:33,980 --> 00:11:40,540
+ما يسمى طبعًا ما يُعرف بالـ Polymorphism. أن الجين 
+
+126
+00:11:40,540 --> 00:11:44,340
+نفسه هو عبارة عن Polymorphic Gene in different
+
+127
+00:11:44,340 --> 00:11:48,300
+individuals في different alleles ماشي و بيسمو هذه
+
+128
+00:11:48,300 --> 00:11:52,040
+الظاهرة within the same species different
+
+129
+00:11:52,040 --> 00:11:55,700
+individuals within a species have slightly
+
+130
+00:11:55,700 --> 00:11:59,420
+different forms يعني عندهم different form of allele
+
+131
+00:11:59,420 --> 00:12:05,000
+و طبعا each class one و class two are different in 
+
+132
+00:12:05,000 --> 00:12:10,660
+different individuals at a single MHC locus الشخص
+
+133
+00:12:10,660 --> 00:12:14,220
+المختلف يمتلك طبيعة مختلفة من الجينات الطبيعية
+
+134
+00:12:14,220 --> 00:12:20,640
+جدا بما أنها متغيرة وفي مجموعات مختلفة يبقى بين
+
+135
+00:12:20,640 --> 00:12:25,260
+الشخص يبقى كل شخص يمتلك مجموعات مختلفة اللي هو
+
+136
+00:12:25,260 --> 00:12:34,920
+الجين يمتلك مجموعات مختلفة جينياً وبالتالي ال
+
+137
+00:12:34,920 --> 00:12:39,720
+product مختلف نهيوما Different alleles are given
+
+138
+00:12:39,720 --> 00:12:50,780
+numbers على سبيل المثال HLA-B15 و HLA-B27 طبعا هذه
+
+139
+00:12:50,780 --> 00:12:54,440
+الظاهرة بتسمى وجود of having multiple stable forms
+
+140
+00:12:54,440 --> 00:12:59,500
+of one gene multiple stable forms of one gene in
+
+141
+00:12:59,500 --> 00:12:59,940
+a population
+
+142
+00:13:02,590 --> 00:13:06,410
+وهذا ما يشكل مجموعة الاماتشي بمجموعة الاماتشي
+
+143
+00:13:06,410 --> 00:13:15,610
+بمجموعة الاماتشي بمجموعة الاماتشي بمجموعة الاماتشي
+
+144
+00:13:15,610 --> 00:13:18,430
+بمجموعة الاماتشي بمجموعة الاماتشي بمجموعة الاماتشي
+
+145
+00:13:18,430 --> 00:13:21,350
+بمجموعة الاماتشي بمجموعة الاماتشي بمجموعة الاماتشي
+
+146
+00:13:21,350 --> 00:13:23,130
+بمجموعة الاماتشي بمجموعة الاماتشي بمجموعة الاماتشي
+
+147
+00:13:23,130 --> 00:13:26,530
+بمجموعة الاماتشي بمجموعة الاماتشي بمجموعة الاماتشي
+
+148
+00:13:26,530 --> 00:13:31,890
+بمجموعة الاماتشي بمجموعة الاماتشي بمجموعة الامات
+
+149
+00:13:32,020 --> 00:13:40,720
+بخلّي هو من جعل ماشي two random individuals express
+
+150
+00:13:40,720 --> 00:13:54,040
+different اللي هو gene the
+
+151
+00:13:54,040 --> 00:13:59,180
+extensive polymorphism of MHC genes makes it very
+
+152
+00:13:59,180 --> 00:14:04,600
+unlikely very unlikely يعني it's not يعني likely
+
+153
+00:14:04,600 --> 00:14:09,460
+found ما بيكون فيه تنين two different individuals
+
+154
+00:14:09,460 --> 00:14:12,880
+two random different individuals have the same or
+
+155
+00:14:12,880 --> 00:14:20,180
+identical set of MHC molecules ال polymorphism هي
+
+156
+00:14:20,180 --> 00:14:24,460
+ال basis of rapid graft rejection هي الأساس
+
+157
+00:14:24,460 --> 00:14:29,470
+between genetically different individuals How can be
+
+158
+00:14:29,470 --> 00:14:37,610
+expressed co-dominantly from both the maternal and
+
+159
+00:14:37,610 --> 00:14:38,950
+the paternal from both the maternal and the
+
+160
+00:14:38,950 --> 00:14:41,490
+paternal from both the maternal and the paternal
+
+161
+00:14:41,490 --> 00:14:43,830
+from both the maternal and the paternal from both
+
+162
+00:14:43,830 --> 00:14:44,390
+the maternal and the paternal from both the
+
+163
+00:14:44,390 --> 00:14:44,790
+maternal and the paternal from both the material
+
+164
+00:14:44,790 --> 00:14:47,210
+and the paternal from both the maternal and the
+
+165
+00:14:47,210 --> 00:14:49,490
+paternal from both the maternal and the paternal
+
+166
+00:14:56,650 --> 00:15:02,630
+كل جسم من أحد الناس يوصف إلى 6 أشخاص مختلفة HLA
+
+167
+00:15:02,630 --> 00:15:09,230
+Class 1 و3 مخصصة لـ HLA Class genes على كل كروموزوم
+
+168
+00:15:09,230 --> 00:15:17,870
+وبالتالي الإنسان ممكن يوصف الاختلاف على سبيل
+
+169
+00:15:17,870 --> 00:15:25,010
+المثال HLA A2 وA5 وB7
+
+170
+00:15:26,500 --> 00:15:36,720
+و B13 و A C6 و C8 طبعا هذا زي ما انتوا شايفين في
+
+171
+00:15:36,720 --> 00:15:42,320
+عنا اتنين HLA A اتنين HLA B واحد maternal واحد
+
+172
+00:15:42,320 --> 00:15:47,280
+paternal و اتنين HLA C C هذا من ال class واحد طبعا
+
+173
+00:15:47,280 --> 00:15:51,520
+عنا ستة ل class واحد تلاتة من ال maternal و تلاتة
+
+174
+00:15:51,520 --> 00:15:57,400
+من ال paternal كمان في عنا ستة ل class two ماشي
+
+175
+00:15:57,400 --> 00:16:00,360
+تلاتة من ال maternal و تلاتة من ال paternal
+
+176
+00:16:00,360 --> 00:16:03,960
+another
+
+177
+00:16:03,960 --> 00:16:07,760
+person may express completely different HLA class
+
+178
+00:16:07,760 --> 00:16:12,380
+6 completely different HLA class 1 طبعا person
+
+179
+00:16:12,380 --> 00:16:16,960
+تاني ممكن يدينا حاجة تاني خالص some individuals may
+
+180
+00:16:16,960 --> 00:16:20,040
+express fewer than 6 طبعا هذا الكلام بيصير لما
+
+181
+00:16:20,040 --> 00:16:23,920
+يكون تانين homozygous for a particular allele
+
+182
+00:16:23,920 --> 00:16:27,440
+بيدينا إيش عدد أقلبالنسبة للموزوم البرمجاني
+
+183
+00:16:27,440 --> 00:16:28,660
+البرمجاني البرمجاني البرمجاني البرمجاني البرمجاني
+
+184
+00:16:28,660 --> 00:16:30,180
+البرمجاني البرمجاني البرمجاني البرمجاني البرمجاني
+
+185
+00:16:30,180 --> 00:16:32,080
+البرمجاني البرمجاني البرمجاني البرمجاني البرمجاني
+
+186
+00:16:32,080 --> 00:16:40,660
+البرمجاني البرمجاني
+
+187
+00:16:40,660 --> 00:16:41,180
+البرمجاني البرمجاني البرمجاني البرمجاني البرمجاني
+
+188
+00:16:41,180 --> 00:16:49,700
+البرمجاني البرمجاني البرمجاني البرمجاني
+
+189
+00:16:49,700 --> 00:16:52,720
+البرمجاني
+
+190
+00:16:53,900 --> 00:17:03,180
+مثل DP Alpha وDP Q وDQ Beta يمكن أن يكونوا موجودين
+
+191
+00:17:03,180 --> 00:17:04,140
+أو يمكن أن يكونوا موجودين أو يمكن أن يكونوا
+
+192
+00:17:04,140 --> 00:17:04,980
+موجودين أو يمكن أن يكونوا موجودين أو يمكن أن
+
+193
+00:17:04,980 --> 00:17:06,400
+يكونوا موجودين أو يمكن أن يكونوا موجودين أو
+
+194
+00:17:06,400 --> 00:17:06,440
+يمكن أن يكونوا موجودين أو يمكن أن يكونوا موجودين
+
+195
+00:17:06,440 --> 00:17:07,420
+موجودين أو يمكن أن يكونوا موجودين أو يمكن أن
+
+196
+00:17:07,420 --> 00:17:08,100
+يكونوا موجودين أو يمكن أن يكونوا موجودين أو يمكن
+
+197
+00:17:08,100 --> 00:17:12,600
+أن يكونوا موجودين أو يمكن أن يكونوا موجودين أو
+
+198
+00:17:12,600 --> 00:17:16,040
+يمكن أن يكونوا هي مجموعة مختلفة من الجينات مثل DB
+
+199
+00:17:16,040 --> 00:17:21,640
+Alpha مع DB مع DQ Beta تنتين تتعامل مع بعض و
+
+200
+00:17:21,640 --> 00:17:22,380
+تتعامل مع بعض و تتعامل مع بعض و تتعامل مع بعض و
+
+201
+00:17:22,380 --> 00:17:24,360
+تتعامل مع بعض و تتعامل مع بعض و تتعامل مع بعض و
+
+202
+00:17:24,360 --> 00:17:24,800
+تتعامل مع بعض و تتعامل مع بعض و تتعامل مع بعض و
+
+203
+00:17:24,800 --> 00:17:25,220
+تتعامل مع بعض و تتعامل مع بعض و تتعامل مع بعض و
+
+204
+00:17:25,220 --> 00:17:26,860
+تتعامل مع بعض و تتعامل مع بعض و تتعامل مع بعض و
+
+205
+00:17:26,860 --> 00:17:29,780
+تتعامل مع بعض و تتعامل مع بعض و تتعامل مع بعض و
+
+206
+00:17:29,780 --> 00:17:37,180
+تتعامل مع بعض و تتعامل مع بعض و
+
+207
+00:17:37,180 --> 00:17:44,890
+تتعامل مع بعمشي and it's passed on as a unit into
+
+208
+00:17:44,890 --> 00:17:52,230
+the offspring بتويرث ك unit فيش لخلف الصالح
+
+209
+00:17:52,230 --> 00:17:57,770
+actually the haplotype of any offspring will differ
+
+210
+00:17:57,770 --> 00:18:00,850
+from the haplotype of a parent طبيعي جدا ال
+
+211
+00:18:00,850 --> 00:18:04,870
+haplotype هو offspring يختلف عن أبوه لأنه ماخد من
+
+212
+00:18:04,870 --> 00:18:11,170
+أمه ومن أبوه MHC Identity You Can Monozygotic Twins
+
+213
+00:18:11,170 --> 00:18:15,410
+الـ Identical MHC molecules بنشوفها in Monozygotic
+
+214
+00:18:15,410 --> 00:18:22,290
+Twins وطبعاً هذا ممكن يصير في أي عيلة it's
+
+215
+00:18:22,290 --> 00:18:26,030
+unlikely to find individuals in general population
+
+216
+00:18:26,030 --> 00:18:31,530
+who are matched at all HLA-Ls إمتيحانة نلاقي two
+
+217
+00:18:31,530 --> 00:18:39,780
+individuals زي بعض ماشي الهم the same HLA alleles
+
+218
+00:18:39,780 --> 00:18:44,640
+Structural molecules طبعا شرحتلكوا إياها بس خلّينا
+
+219
+00:18:44,640 --> 00:18:49,520
+نسترجعه مرة تانية هي MHC class I molecule gene
+
+220
+00:18:49,520 --> 00:18:53,220
+codes for a transmembrane glycoprotein of
+
+221
+00:18:53,220 --> 00:18:56,060
+approximate molecular weight 43 kilo Daltons
+
+222
+00:18:56,060 --> 00:19:03,380
+وبيسموها alpha or heavy chain يعني تسمى كـ Alpha
+
+223
+00:19:03,380 --> 00:19:07,720
+مرة واحدة شيء وهو مجموعة من ثلاث مواقع إكتساسترالية
+
+224
+00:19:07,720 --> 00:19:11,700
+Alpha 1, Alpha 2 وAlpha 3 Beta 2 Microglobulin
+
+225
+00:19:11,700 --> 00:19:16,880
+مشاركة مقابلًا كما قلنا مع MHC Class I molecule
+
+226
+00:19:16,880 --> 00:19:24,140
+ومشاركة بمجلد كروموزوم أخر تمامًا مجلد جين على مجلد
+
+227
+00:19:24,140 --> 00:19:30,250
+كروموزوم أخر يشبه مواقع Microglobulin أنا مجلد من
+
+228
+00:19:30,250 --> 00:19:34,290
+عائلة الـ Superminoglobulin من عائلة الـ
+
+229
+00:19:34,290 --> 00:19:35,490
+Superminoglobulin من عائلة الـ Superminoglobulin
+
+230
+00:19:35,490 --> 00:19:39,170
+من عائلة الـ Superminoglobulin من عائلة الـ
+
+231
+00:19:39,170 --> 00:19:39,950
+Superminoglobulin من عائلة الـ Superminoglobulin
+
+232
+00:19:39,950 --> 00:19:40,290
+من عائلة الـ Superminoglobulin من عائلة الـ
+
+233
+00:19:40,290 --> 00:19:40,970
+Superminoglobulin من عائلة الـ Superminoglobulin
+
+234
+00:19:40,970 --> 00:19:41,130
+Superminoglobulin من عائلة الـ Superminoglobulin
+
+235
+00:19:41,130 --> 00:19:45,070
+Superminoglobulin من عائلة الـ Superminoglobulin
+
+236
+00:19:45,070 --> 00:19:49,290
+من عائلة الـ
+
+237
+00:19:49,290 --> 00:19:56,310
+Superminoglobulin من عائلة الـ Superminoglo
+
+238
+00:19:59,140 --> 00:20:02,680
+في Alpha 1 Alpha 2 الـ Variable Region وين موجودة؟
+
+239
+00:20:02,680 --> 00:20:08,420
+في Alpha 1 Alpha 2 الـ Individual Class I Molecule
+
+240
+00:20:08,420 --> 00:20:14,120
+can be divided into non-polymorphic يعني or
+
+241
+00:20:14,120 --> 00:20:19,340
+invariant region which is similar in all Class I
+
+242
+00:20:19,340 --> 00:20:26,000
+allelic forms طبيعي جدا متشابهةأو مستوى مستوى مستوى
+
+243
+00:20:26,000 --> 00:20:39,480
+مستوى مستوى مستوى مستوى مستوى مستوى
+
+244
+00:20:39,480 --> 00:20:44,900
+مستوى مستوى مستوى
+
+245
+00:20:47,900 --> 00:20:53,760
+والـ Variability بتحددها CD8 بيرتبط بالـ invariant
+
+246
+00:20:53,760 --> 00:20:57,280
+region يعني في ال constant region of MHC
+
+247
+00:20:57,280 --> 00:21:06,660
+class 1 molecule CD8 Allelic specific pocket في عندنا
+
+248
+00:21:06,660 --> 00:21:11,740
+groove or pocket ماشي Determine which peptide
+
+249
+00:21:11,740 --> 00:21:16,800
+binds to a particular allelic form This pocket also
+
+250
+00:21:16,800 --> 00:21:21,080
+helps secure the peptide بما أنها على شكل groove
+
+251
+00:21:21,080 --> 00:21:27,820
+or pocket هي بتحافظ على اللي هو وجود الـ peptide
+
+252
+00:21:27,820 --> 00:21:37,200
+ماشي آمن في هذا الجيب أو الـ pocket in position
+
+253
+00:21:37,200 --> 00:21:40,760
+which can be recognized by a specific TCA بيتثبت
+
+254
+00:21:40,760 --> 00:21:48,160
+بطريقة مثلية بحيث أنه تتعرف عليه الـ TCR بسهولة ونمت
+
+255
+00:21:48,160 --> 00:21:51,320
+الـ MHC موليكيول يتعامل مع عدد كبير من البيبتايد
+
+256
+00:21:51,320 --> 00:22:03,120
+طبيعي جدا ومع سيكوانات مختلفة استكشف
+
+257
+00:22:03,120 --> 00:22:09,160
+ونمت الـ MHC class II موليكيول على نفس النمط ونمت الـ MHC class II برضه
+
+258
+00:22:09,160 --> 00:22:12,160
+Alpha و Beta code for chain of approximate
+
+259
+00:22:12,160 --> 00:22:16,090
+molecular weight وهي مثل الـ Class I، هم مجتمعين
+
+260
+00:22:16,090 --> 00:22:18,370
+متعاملين بالـ Glycoprotein ومجتمعين متعاملين بالـ
+
+261
+00:22:18,370 --> 00:22:19,690
+Cytoplasmic Tail ومجتمعين متعاملين بالـ
+
+262
+00:22:19,690 --> 00:22:24,310
+Extracellular Immunoglobulin ومجموعاتهم Alpha-1
+
+263
+00:22:24,310 --> 00:22:28,230
+وAlpha-2 وBeta-1 وBeta-2 المجموعات MHC Class II هي
+
+264
+00:22:28,230 --> 00:22:30,530
+مجموعة من مجموعات الجنس المتعامل بالأمينoglobulin
+
+265
+00:22:30,530 --> 00:22:36,090
+ومجموعة MHC Class II هي مجموعة من المجموعات
+
+266
+00:22:36,090 --> 00:22:37,050
+المتعاملين بالأمينoglobulin ومجموعة MHC Class II
+
+267
+00:22:37,050 --> 00:22:37,570
+هي مجموعة من المجموعات المتعاملين بالأمينoglobulin
+
+268
+00:22:37,570 --> 00:22:41,890
+ومجموعة MHC Class II هي مجموعة من المجموعة الـ T
+
+269
+00:22:41,890 --> 00:22:46,370
+cell molecule CD4 يرتبط بالـ constant H بالـ
+
+270
+00:22:46,370 --> 00:22:49,970
+invariant portion يعني بالـ constant region of MHC
+
+271
+00:22:49,970 --> 00:22:57,830
+class 2 موليكيول الجروز هنا هو عبارة عن اللي هو
+
+272
+00:22:57,830 --> 00:23:03,590
+or cleft it's structurally analogous to the MHC
+
+273
+00:23:03,590 --> 00:23:09,380
+class 1 موليكيول لكن هنا الـ cleft بيكون أكبر .. open
+
+274
+00:23:09,380 --> 00:23:14,620
+وبالتالي بيستطيع أنه يرتبط بحجم أكبر من الـ بيبتايد
+
+275
+00:23:14,620 --> 00:23:21,320
+البروتين الأكسوجينيين هم الانتجين هم أخذوه من جسد
+
+276
+00:23:21,320 --> 00:23:22,920
+البروتين الانتجينيين الابتسامات البروتين
+
+277
+00:23:22,920 --> 00:23:24,140
+الابتسامات البروتين الابتسامات البروتين الابتسامات
+
+278
+00:23:24,140 --> 00:23:27,580
+البروتين الابتسامات البروتين الابتسامات البروتين
+
+279
+00:23:27,580 --> 00:23:27,840
+الابتسامات البروتين الابتسامات البروتين الابتسامات
+
+280
+00:23:27,840 --> 00:23:28,020
+البروتين الابتسامات البروتين الابتسامات البروتين
+
+281
+00:23:28,020 --> 00:23:31,840
+الابتسامات البروتين الابتسامات البروتين الابتسامات
+
+282
+00:23:31,840 --> 00:23:36,540
+البروتين هذه الرابطة اللي بيبتعد أو هذا الـ complex
+
+283
+00:23:36,540 --> 00:23:43,020
+MHC class 2 complex بينتقل إلى cell surface
+
+284
+00:23:43,020 --> 00:23:50,160
+و هناك بيرتبط بيتقدم للـ TCR و الـ TCR بتعرف عليه و الـ
+
+285
+00:23:50,160 --> 00:23:55,740
+exogenous بيتقدم للـ CD4 T lymphocyte و الـ CD4 أيضا
+
+286
+00:23:55,740 --> 00:24:02,830
+بترتبط فيه هذا هو عملية الـ Antigen Processing and
+
+287
+00:24:02,830 --> 00:24:06,050
+Presentation الـ Processing هي عملية التشريف أو
+
+288
+00:24:06,050 --> 00:24:09,770
+التقطيع للـ Antigen والـ Presentation عملية تقديمه
+
+289
+00:24:09,770 --> 00:24:14,190
+لمين الـ T lymphocytes أي Exogenous Antigen مثل الـ
+
+290
+00:24:14,190 --> 00:24:21,390
+Virus Protein أو في مجال مجال مجال مجال مجال مجال
+
+291
+00:24:21,390 --> 00:24:21,550
+مجال مجال مجال مجال مجال مجال مجال مجال مجال مجال
+
+292
+00:24:21,550 --> 00:24:21,570
+مجال مجال مجال مجال مجال مجال مجال مجال مجال مجال
+
+293
+00:24:21,570 --> 00:24:21,790
+مجال مجال مجال مجال مجال مجال مجال مجال مجال مجال
+
+294
+00:24:21,790 --> 00:24:22,010
+مجال مجال مجال مجال مجال مجال مجال مجال مجال مجال
+
+295
+00:24:22,010 --> 00:24:25,650
+مجال مجال مجال مجال مجال
+
+296
+00:24:27,520 --> 00:24:38,280
+ماشي ذهب بعد ذلك إلى اللي هو الـ MHC molecule أو الـ
+
+297
+00:24:38,280 --> 00:24:42,600
+endoplasmic reticulum ايه ذهب هنا الـ endoplasmic
+
+298
+00:24:42,600 --> 00:24:53,520
+reticulum مرة ثانية هي الفيروس اتاخد و اتقطع و دخل
+
+299
+00:24:53,520 --> 00:25:00,490
+in ايه physical دخل in ايه وهي عبارة عن acidic
+
+300
+00:25:00,490 --> 00:25:07,410
+vesicle في مكان آخر في الخلية في الـ endoplasmic
+
+301
+00:25:07,410 --> 00:25:12,070
+reticulum يتم تصنيع اللي هو الـ MHC Class 2 في الـ
+
+302
+00:25:12,070 --> 00:25:15,110
+endoplasmic reticulum ثم ينتقل إلى جولجي أبراطوس
+
+303
+00:25:15,110 --> 00:25:23,350
+وينتقل مرتبط بـ Antigen اسمه CD474
+
+304
+00:25:24,960 --> 00:25:34,100
+ماشي أو 74 أو بين جسين الـ I طبعا بيطلع من جولجي
+
+305
+00:25:34,100 --> 00:25:41,120
+أبراطوس على الـ cytosol و بيطلع هنا vesicle و في
+
+306
+00:25:41,120 --> 00:25:48,620
+داخل الـ vesicle هذا بيتقطع CD4074 و بيبقى لنا جزء
+
+307
+00:25:48,620 --> 00:25:53,040
+بسيط منه اسمه CLIP ماشي
+
+308
+00:25:55,350 --> 00:26:00,830
+هذا الجزء البسيط بطريقة مرتبطة لما تكون موليكيول
+
+309
+00:26:00,830 --> 00:26:04,330
+أنها physical طبعا في الـ cytosol حركة الخلية
+
+310
+00:26:04,330 --> 00:26:09,850
+الدائمة تجعل الـ two physical to be what؟ to be
+
+311
+00:26:09,850 --> 00:26:15,770
+fused together و بيتكونوا ايه؟ أنهم يصبحوا أنهم
+
+312
+00:26:15,770 --> 00:26:19,770
+physical واحدة لما تكون Class two والانتجن يصبح
+
+313
+00:26:19,770 --> 00:26:22,970
+أنها physical طبعا في هذه الحالة بيصير في exchange
+
+314
+00:26:22,970 --> 00:26:26,650
+بين الـ CLIP و الـ Antigen فبيجي الـ Antigen و بيقعد
+
+315
+00:26:26,650 --> 00:26:33,570
+محل الـ CLIP و بيطلع الـ MHC بعد هيك على سطح الخلية
+
+316
+00:26:33,570 --> 00:26:40,010
+مرتبط به MHC class 2 molecule هذا الـ pathway تبع
+
+317
+00:26:40,010 --> 00:26:40,690
+الـ exogenous
+
+318
+00:26:43,610 --> 00:26:47,170
+أيو The response of CD4-T cell is referred to as
+
+319
+00:26:47,170 --> 00:26:50,570
+restricted by MHC class 2 molecule طبيعي جدا في
+
+320
+00:26:50,570 --> 00:26:54,930
+MHC restriction ما احنا قلنا في الـ T cell
+
+321
+00:26:54,930 --> 00:27:00,090
+activation شرحنا أن في لما تدخل تلينفوسايت الثايمس
+
+322
+00:27:00,090 --> 00:27:05,250
+و بتتطور في الثايمس تتعرض إلى امتحانين امتحان
+
+323
+00:27:05,250 --> 00:27:11,410
+الأولان بتطلع منه شاطرة و بتعرف فقط
+
+324
+00:27:12,400 --> 00:27:18,280
+تتعامل مع الـ MHC اللي شافته يعني مستقبلا لم
+
+325
+00:27:18,280 --> 00:27:23,480
+تتعامل مع Foreign MHC molecule فقط هتتعرف على الـ
+
+326
+00:27:23,480 --> 00:27:31,940
+MHC اللي شافته فيه أثناء تعليمها وبالتالي سمينا
+
+327
+00:27:31,940 --> 00:27:38,760
+هذه الظاهرة MHC Restricted Phenomena أو
+
+328
+00:27:38,760 --> 00:27:43,280
+بيسموها Self MHC Class II Molecule أما الـ
+
+329
+00:27:43,280 --> 00:27:45,260
+Exogenous Antigen يمكن أن يتم تجريبه من الـ
+
+330
+00:27:45,260 --> 00:27:49,760
+Pathogen مثل البكتيريا أو الفيروسات أو من البروتين
+
+331
+00:27:49,760 --> 00:27:55,000
+الخارجي مثل الـ S-Vaccine التي لا تؤذي المستخدم بل
+
+332
+00:27:55,000 --> 00:28:01,700
+تفعيل تجارب الـ immune طبعا شفنا هذا في الفيجور 8.5
+
+333
+00:28:01,700 --> 00:28:06,760
+يظهر التجارب ومعرفة تجارب الـ Exogenous Antigen
+
+334
+00:28:06,760 --> 00:28:12,690
+بشكل طبيعي بروتين انجكتكمبونات من الفيروس
+
+335
+00:28:12,690 --> 00:28:17,950
+الانتيجيني أو الانتيجيني الفيروس البروتين مدخل
+
+336
+00:28:17,950 --> 00:28:23,230
+بشكل فيزيكي انترالي يدخل في شكل فيزيكي انترالي
+
+337
+00:28:23,230 --> 00:28:25,810
+يدخل في شكل فيزيكي انترالي يدخل في شكل فيزيكي
+
+338
+00:28:25,810 --> 00:28:25,830
+انترالي يدخل في شكل فيزيكي انترالي يدخل في
+
+339
+00:28:25,830 --> 00:28:28,790
+فيزيكي انترالي يدخل في شكل فيزيكي انترالي يدخل في
+
+340
+00:28:28,790 --> 00:28:30,390
+شكل فيزيكي انترالي يدخل في شكل فيزيكي انترالي يدخل
+
+341
+00:28:30,390 --> 00:28:34,630
+في شكل فيزيكي انترالي يدخل في شكل فيزيكي انترالي
+
+342
+00:28:34,630 --> 00:28:39,050
+يدخل This physical تحتوي على مجموعة من
+
+343
+00:28:39,050 --> 00:28:42,350
+البروتيوليتيك انزايم البروتييزي نوز أثكا ثابسين
+
+344
+00:28:42,350 --> 00:28:45,710
+ووظيفتها
+
+345
+00:28:45,710 --> 00:28:49,970
+أنها تقلل البياتشت وبالتالي بيصير في عملية تقطيع
+
+346
+00:28:49,970 --> 00:28:59,030
+أيضا للبروتين into بيبتايد بعد هي كلامات Class II
+
+347
+00:28:59,030 --> 00:29:03,130
+موليكيول Alpha Beta اللي بتصنع individually في ال
+
+348
+00:29:03,130 --> 00:29:10,100
+endoplasmic reticulum CD74 مرتبط مع CD4T74 انفرادات
+
+349
+00:29:10,100 --> 00:29:14,100
+انفرادات انفرادات انفرادات انفرادات انفرادات
+
+350
+00:29:14,100 --> 00:29:18,900
+انفرادات انفرادات انفرادات انفرادات انفرادات
+
+351
+00:29:18,900 --> 00:29:19,720
+انفرادات انفرادات انفرادات انفرادات انفرادات
+
+352
+00:29:19,720 --> 00:29:19,840
+انفرادات انفرادات انفرادات انفرادات انفرادات
+
+353
+00:29:19,840 --> 00:29:24,480
+انفرادات انفرادات انفرادات انفرادات انفرادات
+
+354
+00:29:24,480 --> 00:29:31,260
+انفرادات انفرادات
+
+355
+00:29:34,400 --> 00:29:38,640
+وبالتالي الـ MHC تترك اندولازميكستيكولان لجهاز
+
+356
+00:29:38,640 --> 00:29:42,880
+البراتوز الجالجي ومن هنا تتعامل بالطريقة
+
+357
+00:29:42,880 --> 00:29:48,520
+الاندوسيتيكية الاندوسيتيكية الاسودية تتعامل بالطريقة
+
+358
+00:29:48,520 --> 00:29:49,940
+الاندوسيتيكية الاندوسيتيكية الاسودية تتعامل بالطريقة
+
+359
+00:29:49,940 --> 00:29:50,860
+الاندوسيتيكية الاندوسيتيكية الاسودية تتعامل بالطريقة
+
+360
+00:29:50,860 --> 00:29:51,960
+الاندوسيتيكية الاندوسيتيكية الاسودية تتعامل بالطريقة
+
+361
+00:29:51,960 --> 00:29:53,740
+الاندوسيتيكية الاندوسيتيكية الاسودية تتعامل بالطريقة
+
+362
+00:29:53,740 --> 00:29:57,580
+الاندوسيتيكية
+
+363
+00:29:57,580 --> 00:30:01,380
+الاندوسيتيكية الاسودية تتعامل بالطريقة
+
+364
+00:30:04,620 --> 00:30:10,620
+بتتم على مراحل تتكسّر، تترك الفرق المعروف كـ CLIP
+
+365
+00:30:10,620 --> 00:30:15,240
+CLIP اختصار لـ Class II associated invariant
+
+366
+00:30:15,240 --> 00:30:20,240
+polypeptide CLIP اختصار لـ Class II associated
+
+367
+00:30:20,240 --> 00:30:25,400
+invariant polypeptide ترتبط بالـ MHC Class II
+
+368
+00:30:25,400 --> 00:30:29,140
+group للـ physical containing MHC Class II
+
+369
+00:30:29,140 --> 00:30:34,000
+molecule bound to CLIP بعد ذلك بيصل لها fusion with
+
+370
+00:30:34,000 --> 00:30:36,760
+the acid vesicle اللي بتحتوي على الانتجين أو الـ
+
+371
+00:30:36,760 --> 00:30:39,640
+peptide-derived from the catabolism of exogenous
+
+372
+00:30:39,640 --> 00:30:46,120
+antigen وفي هذا المكان موليكيول non-HLA-DM بيعمل
+
+373
+00:30:46,120 --> 00:30:52,680
+عملية catalysis للـ peptide و exchange و exchange
+
+374
+00:30:52,680 --> 00:30:57,840
+يعني بيشيل اللي هو الـ CLIP و بيحط منه الـ
+
+375
+00:30:57,840 --> 00:31:01,840
+antigenic peptide اللي جاية من الـ Exogenous
+
+376
+00:31:01,840 --> 00:31:07,220
+Antigen. الـ Endogenous Protein, generally derived 
+
+377
+00:31:07,220 --> 00:31:11,220
+from infectious pathogen, come from within cells
+
+378
+00:31:11,220 --> 00:31:14,640
+and are processed to peptide inside the cell، وهنا
+
+379
+00:31:14,640 --> 00:31:17,680
+جيت، هنشوف الميكانيزم، peptide derived from this
+
+380
+00:31:17,680 --> 00:31:21,640
+protein interact with MHC Class I molecule. يعني
+
+381
+00:31:21,640 --> 00:31:26,210
+الـ Endogenous Protein اللي بيتولد في داخل
+
+382
+00:31:26,210 --> 00:31:32,530
+الخلية، بتقطيعه، ثم بيدخل في الـ cytosol، ثم بيدخل 
+
+383
+00:31:32,530 --> 00:31:36,890
+إلى الـ endoplasmic reticulum اللي بيصنع الـ MHC 
+
+384
+00:31:36,890 --> 00:31:39,650
+Class I molecule، و هناك بيرتبط فيه
+
+385
+00:31:39,650 --> 00:31:45,330
+الـ peptide. وده هي الحكاية. أيوة، فيروس
+
+386
+00:31:53,960 --> 00:31:59,420
+ماشي دخل صار في synthesis of viral protein فصار في
+
+387
+00:31:59,420 --> 00:32:06,040
+أن الـ protein تكون طبعا بيتلقفوا بـ proteasome و
+
+388
+00:32:06,040 --> 00:32:10,320
+الـ proteasome بيشكفوا إلى قطع صغيرة من 8 إلى 15
+
+389
+00:32:10,320 --> 00:32:16,760
+amino acids طبعا بعد هيك بيدخل الـ antigen أو الـ
+
+390
+00:32:16,760 --> 00:32:20,680
+antigenic peptide إلى الـ endoplasmic reticulum في
+
+391
+00:32:20,680 --> 00:32:23,700
+الـ Endoplasmic reticulum ده يتم تصنيع لـ MHC
+
+392
+00:32:23,700 --> 00:32:28,660
+Class I ماشي و الـ Beta 2-Microglobulin بعد هيك
+
+393
+00:32:28,660 --> 00:32:33,740
+بتصنع لـ MHC Class I بعد هيك بيرتبط مباشرة بالـ
+
+394
+00:32:33,740 --> 00:32:37,000
+Antigenic peptide بعد هيك بيطلع على الـ Golgi apparatus
+
+395
+00:32:37,000 --> 00:32:40,420
+و بالـ Golgi apparatus على الـ cell surface membrane
+
+396
+00:32:40,420 --> 00:32:45,800
+مرتبط بمين؟ بالـ MHC Class I الملكي اللي بتقدم لمين؟
+
+397
+00:32:45,800 --> 00:32:46,720
+لـ CD8
+
+398
+00:32:50,850 --> 00:32:54,330
+الـ MHC Class I Complex is transported to the
+
+399
+00:32:54,330 --> 00:32:58,050
+cell surface نفس الحق اللي توشر أحتوى ده هو Where
+
+400
+00:32:58,050 --> 00:33:01,270
+it interacts with the T lymphocyte receptor اللي
+
+401
+00:33:01,270 --> 00:33:05,910
+على سطحها CD8 The response of CD8 positive T cell
+
+402
+00:33:05,910 --> 00:33:09,730
+is referred to as restricted by MHC Class I
+
+403
+00:33:09,730 --> 00:33:13,690
+molecule أما يسمى بالسلف MHC Class I molecule
+
+404
+00:33:15,440 --> 00:33:18,760
+الخلايا الـ MHC Class-I موجودة في جميع جسم
+
+405
+00:33:18,760 --> 00:33:22,820
+النوكليات الاندوجيني
+
+406
+00:33:22,820 --> 00:33:28,290
+يمكن أن تحدث في أي خلية من خلايا جسم الإنسان بسبب
+
+407
+00:33:28,290 --> 00:33:33,230
+أن الـ pathogen يمكن أن يشبه أي سيلف في الجسم CD8 T
+
+408
+00:33:33,230 --> 00:33:40,150
+-cell can scan يعني لما تتجول أو تمشي phenomena تبحث
+
+409
+00:33:40,150 --> 00:33:44,490
+عن MHC Class I molecule Peptide and Peptide
+
+410
+00:33:44,490 --> 00:33:50,310
+combination طبعا موجودين على أي نوكلياتد سل و هناك
+
+411
+00:33:50,310 --> 00:33:58,350
+بتعرف عليهم و ممكن يصير ايش ارتباط عن طريق الـ 9.1
+
+412
+00:33:58,350 --> 00:34:02,050
+في الـ comparison بين لما الـ MHC class 1 و2 هرجتها
+
+413
+00:34:02,050 --> 00:34:06,330
+نشوفه proteins from bacteria, virus, allergen, or
+
+414
+00:34:06,330 --> 00:34:12,590
+harmless antigen may يقدموا لـ CD4-T lymphocytes
+
+415
+00:34:12,590 --> 00:34:18,310
+بينما pathogen infected cell زي بكتيريا الفيروس
+
+416
+00:34:18,310 --> 00:34:23,800
+create Epitopes في الداخلها بالنسبة لـ CD8-T
+
+417
+00:34:23,800 --> 00:34:26,480
+-Lymphocyte برنامج الوصول إلى CD8-T-Lymphocyte
+
+418
+00:34:26,480 --> 00:34:27,000
+برنامج الوصول إلى CD8-T-Lymphocyte برنامج الوصول
+
+419
+00:34:27,000 --> 00:34:29,120
+إلى CD8-T-Lymphocyte برنامج الوصول إلى CD8-T
+
+420
+00:34:29,120 --> 00:34:29,860
+-Lymphocyte برنامج الوصول إلى CD8-T-Lymphocyte
+
+421
+00:34:29,860 --> 00:34:31,320
+برنامج الوصول إلى CD8-T-Lymphocyte برنامج الوصول
+
+422
+00:34:31,320 --> 00:34:32,600
+إلى CD8-T-Lymphocyte برنامج الوصول إلى CD8-T
+
+423
+00:34:32,600 --> 00:34:35,500
+-Lymphocyte برنامج الوصول إلى CD8-T-Lymphocyte
+
+424
+00:34:35,500 --> 00:34:41,300
+برنامج الوصول إلى CD8-T-Lymphocyte برنامج الوصول
+
+425
+00:34:41,300 --> 00:34:49,480
+إلى CD8-T-Lymphocy
+
+426
+00:34:51,330 --> 00:34:54,630
+إن الـ Antigen اتقدم لـ CD4 أو CD8 هو طبيعة الـ
+
+427
+00:34:54,630 --> 00:34:59,050
+Antigen إذا كان Indigenous أو Exogenous طبعا بعض
+
+428
+00:34:59,050 --> 00:35:02,330
+المرات بيحصل في cross-presentation pathway cross
+
+429
+00:35:02,330 --> 00:35:05,390
+-presentation يعني يعني بيكون Exogenous الـ
+
+430
+00:35:05,390 --> 00:35:09,450
+Antigen اتقدم لمين؟ لـ CD8 اتبط بـ MHC Class I molecule
+
+431
+00:35:09,450 --> 00:35:13,290
+و اتقدم لمين؟ لـ CD8 و بيسمو هذه الظاهرة cross
+
+432
+00:35:13,290 --> 00:35:18,590
+-presentation pathway Super Antigen هي عبارة عن
+
+433
+00:35:18,590 --> 00:35:23,370
+أنتيجينات كبيرة نص دي إن أي بره أنتيكسن و أحسن مثال
+
+434
+00:35:23,370 --> 00:35:27,990
+الـ Staphylococcal enterotoxin بيرتبط بالـ MHC class 2
+
+435
+00:35:27,990 --> 00:35:32,630
+molecule بدون ما يصير له processing و الـ super
+
+436
+00:35:32,630 --> 00:35:37,050
+antigen بيرتبط من برا لبرا بالـ TCR بالـ MHC class 2
+
+437
+00:35:37,050 --> 00:35:45,310
+molecule و بالتالي بربط الـ MHC مع الـ TCR من برا
+
+438
+00:35:45,310 --> 00:35:49,110
+لبرا ماشي
+
+439
+00:35:50,780 --> 00:35:53,820
+بيرتبط من خلال الـ Vα و من خلال الـ VB Variable
+
+440
+00:35:53,820 --> 00:35:59,000
+Beta Region of TCR Superantigen يوم ما يكون فيه
+
+441
+00:35:59,000 --> 00:36:02,400
+Superantigen بنشط حوالي عشرة في المية من الـ total
+
+442
+00:36:02,400 --> 00:36:06,840
+number of T-lymphocyte وده بيؤدي 
+
+443
+00:36:06,840 --> 00:36:10,860
+لـ apoptosis و كميات كبيرة لما يصير shutting down للـ
+
+444
+00:36:10,860 --> 00:36:14,610
+immune response activation of innate cell have
+
+445
+00:36:14,610 --> 00:36:19,050
+clinical consequences هذا الموضوع مش سهل وبالتالي
+
+446
+00:36:19,050 --> 00:36:23,010
+من its side effect بتبعته هو انه مسئول على shock
+
+447
+00:36:23,010 --> 00:36:28,770
+like syndrome و بيعمل toxic shock عند ايش؟ عند
+
+448
+00:36:28,770 --> 00:36:35,590
+المريض inability to respond to an antigen ليش بعض
+
+449
+00:36:35,590 --> 00:36:41,610
+المرات بيكون في ايش؟ بيكون اللي هو عدم القدرة for a
+
+450
+00:36:41,610 --> 00:36:45,630
+response for a new response to respond against
+
+451
+00:36:45,630 --> 00:36:52,890
+antigen وببساطة أفسر لكم أو أجمل لكم هذه الـ slide يوم
+
+452
+00:36:52,890 --> 00:37:02,770
+الـ MHC molecule مرتبط بـ self-antigen اللي
+
+453
+00:37:02,770 --> 00:37:06,960
+لو اتقدم لـ T lymphocyte الـ T-Lymphocyte لا تتنشط
+
+454
+00:37:06,960 --> 00:37:09,840
+والسبب في ذلك انه ما بيصير فيه expression
+
+455
+00:37:09,840 --> 00:37:14,880
+لـ costimulator احنا بنعرف انه بيكون فيه عشان تتنشط
+
+456
+00:37:14,880 --> 00:37:18,280
+الـ T-Lymphocyte بيحتاج Signal واحدة اللي هو
+
+457
+00:37:18,280 --> 00:37:22,780
+الارتباط و الثانية formation of costimulation ما فيش
+
+458
+00:37:22,780 --> 00:37:25,940
+costimulation معناته في energized cell معناته
+
+459
+00:37:25,940 --> 00:37:32,230
+الخلية لا تتنشط لا تتنشط لكن إذا كان الخلية أو الـ
+
+460
+00:37:32,230 --> 00:37:38,110
+MHC مرتبطة بـ foreign antigen بيتكون عادةً الـ Co
+
+461
+00:37:38,110 --> 00:37:44,270
+-Stimulation Signal وبالتالي بيحصل فيه Response
+
+462
+00:37:44,270 --> 00:37:47,610
+Exposure
+
+463
+00:37:47,610 --> 00:37:51,050
+to foreign antigen دة Induced Tissue Damage والـ
+
+464
+00:37:51,050 --> 00:37:56,290
+Tissue Damage بيسموها Danger Hypothesis and the
+
+465
+00:37:56,290 --> 00:38:02,230
+Danger Signal Activate T Cell هذه نظرية تشرح لماذا
+
+466
+00:38:02,230 --> 00:38:07,650
+تلينفوسايت تتفاعل مع أنتجين غير مجرد موليكيوليات
+
+467
+00:38:07,650 --> 00:38:14,450
+نفسها يعني أنتجين تتكون في حيبوتسيس خطر تتولد
+
+468
+00:38:14,450 --> 00:38:19,630
+إشعار خطر وسببها أن هناك Tissue Damage هناك إشعار Tissue
+
+469
+00:38:19,630 --> 00:38:23,810
+Damage طبعا في هذه الحالة يحدث Costimulation و Response
+
+470
+00:38:31,270 --> 00:38:37,950
+لأن بعض أنواع الـ T-lymphocyte كانت موجودة على
+
+471
+00:38:37,950 --> 00:38:41,510
+كل الـ cell wall أو الـ pathogen مثل الـ
+
+472
+00:38:41,510 --> 00:38:45,430
+Mycobacterium tuberculosis اللي متعيش في داخل الـ
+
+473
+00:38:45,430 --> 00:38:51,850
+macrophage هذه الموليكيوه بتواجه بـ CD1 اللي عبارة
+
+474
+00:38:51,850 --> 00:38:56,970
+عن CD1A و CD1D وهذا بيصير طبعا expressed by antigen
+
+475
+00:38:56,970 --> 00:38:59,190
+presenting cell مثل الـ macrophage و الـ dendritic
+
+476
+00:38:59,190 --> 00:38:59,470
+cell
+
+477
+00:39:03,530 --> 00:39:07,270
+CD1 molecule موجودة على الـ Cell Surface of
+
+478
+00:39:07,270 --> 00:39:07,330
+Antigen-Presenting Cell أيضًا مرتبطة بـ Mycobacterium
+
+479
+00:39:07,330 --> 00:39:11,370
+tuberculosis. موجودة على الـ Cell Surface of Antigen
+
+480
+00:39:11,370 --> 00:39:14,170
+-Presenting Cell أيضًا مرتبطة بـ Mycobacterium
+
+481
+00:39:14,170 --> 00:39:17,330
+tuberculosis. موجودة على الـ Cell Surface of Antigen
+
+482
+00:39:17,330 --> 00:39:17,550
+-Presenting Cell أيضًا مرتبطة بـ Mycobacterium
+
+483
+00:39:17,550 --> 00:39:20,430
+tuberculosis. موجودة على الـ Cell Surface of Antigen
+
+484
+00:39:20,430 --> 00:39:25,410
+-Presenting Cell أيضًا مرتبطة بـ Mycobacterium
+
+485
+00:39:25,410 --> 00:39:28,110
+tuberculosis. موجودة على الـ Cell Surface of Antigen
+
+486
+00:39:28,110 --> 00:39:29,410
+-Presenting Cell أيضًا مرتبطة بـ Mycobacterium
+
+487
+00:39:29,410 --> 00:39:32,750
+tuberculosis. موجودة على الـ Cell Surface of Antigen
+
+488
+00:39:32,750 --> 00:39:35,870
+-Presenting Cell أيضًا مرتبطة طبعاً الـ poorer
+
+489
+00:39:35,870 --> 00:39:46,610
+region of lipid بترتبط بالـ TCR التباطؤ الـ lipid
+
+490
+00:39:46,610 --> 00:39:51,250
+antigen to CD1 is believed to take a place in
+
+491
+00:39:51,250 --> 00:39:54,730
+acidic cellular compartment زي ما بيحصل في loading
+
+492
+00:39:54,730 --> 00:39:59,230
+للـ exogenous peptide with MHC class II molecule
+
+493
+00:40:00,700 --> 00:40:09,160
+CD1A, B, and C present limit to T cell that use an
+
+494
+00:40:09,160 --> 00:40:17,220
+alpha beta TCR لكن CD1D يعني A وB وC بيقدموا تلك
+
+495
+00:40:17,220 --> 00:40:21,760
+الـ TCR لكن CD1D present limit and like of limit to
+
+496
+00:40:21,760 --> 00:40:24,300
+NK T cell
+
+497
+00:40:29,220 --> 00:40:33,980
+طبعا هي TCR هي
+
+498
+00:40:33,980 --> 00:40:39,240
+الـ non polar في الداخل و الـ polar برا طبعا الـ non
+
+499
+00:40:39,240 --> 00:40:46,560
+polar هي بتقدم لمين؟ لـ CD1 طبعا زي ما أنتو
+
+500
+00:40:46,560 --> 00:40:49,620
+شايفين resembling مين؟ resembling اللي هو class
+
+501
+00:40:49,620 --> 00:40:53,840
+one molecule مرتبطة بـ beta 2 microglobulin و ال
+
+502
+00:40:53,840 --> 00:41:07,690
+polar بيكون باتجاه ايش؟ باتجاه MHC Class 2 CD1
+
+503
+00:41:07,690 --> 00:41:16,370
+هو Class 1 و Polar بتجاه TCR بتجاه TCR
+
+504
+00:41:16,370 --> 00:41:22,310
+Alpha Beta Super Antigen من برا لورا بشبك MHC
+
+505
+00:41:22,310 --> 00:41:27,640
+Molecule وهذه الـ Comparison بين MSC Class I و Class
+
+506
+00:41:27,640 --> 00:41:35,640
+II وطبعا كل النقاط اللي احنا حكينا فيها و MSC and
+
+507
+00:41:35,640 --> 00:41:40,700
+immune response طبعا هنا احنا الكلام اللي حكيناه
+
+508
+00:41:40,700 --> 00:41:43,900
+بس خلينا نعيده مرة تانية نعرف ان الـ MSC molecule
+
+509
+00:41:43,900 --> 00:41:47,380
+play a critical role in response of T lymphocytes
+
+510
+00:41:47,380 --> 00:41:56,120
+في داخل الـ human body طبعا برتبط ببيبتايد من
+
+511
+00:41:56,120 --> 00:42:01,140
+البروتين وبيقدم هذا الـ بيبتايد للـ تي لينفوسايتس
+
+512
+00:42:01,140 --> 00:42:04,160
+without preparate receptor وبالتالي الـ T cell
+
+513
+00:42:04,160 --> 00:42:09,240
+response are said to be MSC restricted MSC
+
+514
+00:42:09,240 --> 00:42:20,240
+restricted فنومينا هي مرة تانية هي ان الـ الـ الـ TCR
+
+515
+00:42:20,240 --> 00:42:22,600
+TCR
+
+516
+00:42:23,360 --> 00:42:30,400
+لما يجي يرتبط بالانتيجن لن يرتبط إلا من خلال الـ
+
+517
+00:42:30,400 --> 00:42:35,860
+self MHC molecule MHC code for two majors category
+
+518
+00:42:35,860 --> 00:42:43,700
+class 1 و class 2 على كل الخلايا بينما كلاس 2
+
+519
+00:42:43,700 --> 00:42:47,560
+موجودين على الـ antigen presenting cell expression
+
+520
+00:42:47,560 --> 00:42:51,180
+of MSC molecule is inducible لبعض الـ cytokine
+
+521
+00:42:51,180 --> 00:42:56,520
+بتطلعه لانفكشوز agents ممكن يزود الاتعام الـ
+
+522
+00:42:56,520 --> 00:43:02,580
+upregulation له كل individual بإمكانها أن تتعامل مع
+
+523
+00:43:02,580 --> 00:43:04,280
+مجموعات مختلفة ومختلفة ومختلفة ومختلفة ومختلفة
+
+524
+00:43:04,280 --> 00:43:07,220
+ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة
+
+525
+00:43:07,220 --> 00:43:12,960
+ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة
+
+526
+00:43:12,960 --> 00:43:16,340
+ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة
+
+527
+00:43:16,340 --> 00:43:16,360
+ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة
+
+528
+00:43:16,360 --> 00:43:20,100
+ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة ومختلفة
+
+529
+00:43:20,100 --> 00:43:27,420
+ومخت
+
+530
+00:43:28,540 --> 00:43:31,480
+من خلال واحد من الانسان الـ MSC class 1 و class 2
+
+531
+00:43:31,480 --> 00:43:39,620
+موليكيول يتعرفون على كل جسم من الجسم و يتعرفون
+
+532
+00:43:39,620 --> 00:43:41,580
+على كل جسم من الجسم و يتعرفون على كل جسم من الجسم
+
+533
+00:43:41,580 --> 00:43:45,600
+و يتعرفون على كل جسم من الجسم و يتعرفون على كل جسم
+
+534
+00:43:45,600 --> 00:43:45,920
+من الجسم و يتعرفون على كل جسم من الجسم و يتعرفون
+
+535
+00:43:45,920 --> 00:43:46,500
+و يتعرفون على كل جسم من الجسم و يتعرفون على كل جسم
+
+536
+00:43:46,500 --> 00:43:54,300
+من الجسم و 
+
+537
+00:43:54,300 --> 00:43:57,350
+يهي عبارة عن الـ variable فيها الـ deep groove و
+
+538
+00:43:57,350 --> 00:44:02,410
+اللي برتبط بالـ peptide ماشي بعد مسلو processing
+
+539
+00:44:02,410 --> 00:44:05,830
+the binding of peptide to MSC molecule is selective
+
+540
+00:44:05,830 --> 00:44:10,070
+each MSC molecule برتبط بـ with a distinct subset
+
+541
+00:44:10,070 --> 00:44:15,190
+of peptide with a particular motif طبيعي جدا حسب
+
+542
+00:44:15,190 --> 00:44:19,330
+إيش قسمنا الانتيجينات إلى اندوجينوس و إكسوجينوس هايوا
+
+543
+00:44:19,330 --> 00:44:26,660
+الإكسوجينوس انتيجين يتم إتباعها بـ 2 بيبتايدات في مخزن
+
+544
+00:44:26,660 --> 00:44:32,380
+الأسود اللي بيطبط بالـ MSC Class II موليكيول ثم MSC
+
+545
+00:44:32,380 --> 00:44:36,060
+Class II موليكيول بيبتايد كومبليكس بينتقل على
+
+546
+00:44:36,060 --> 00:44:41,520
+surface of the cell و بتقدم لها TCR of CD4 T cell
+
+547
+00:44:42,950 --> 00:44:45,830
+فهو بيصير في responding من الـ TCR و بيسموه
+
+548
+00:44:45,830 --> 00:44:50,350
+response هو عبارة عن restricted by MSC class 2
+
+549
+00:44:50,350 --> 00:44:54,990
+موليكيول أو self MSC class 2 موليكيول و الحاجة
+
+550
+00:44:54,990 --> 00:44:59,590
+التانية قولنا endogenous protein generally derived
+
+551
+00:44:59,590 --> 00:45:06,290
+from infectious pathogen و طبعا بيسله بيتكوم في
+
+552
+00:45:06,290 --> 00:45:11,570
+اللي هو في
+
+553
+00:45:11,570 --> 00:45:12,290
+الـ cytosol
+
+554
+00:45:15,100 --> 00:45:17,780
+هو يبقى الـ peptide derived from this protein
+
+555
+00:45:17,780 --> 00:45:20,780
+interact with MHC class 1 molecule وبيطلع بعد ذلك
+
+556
+00:45:20,780 --> 00:45:27,000
+الـ MHC class 1 peptide complex على سطح الخلية اللي
+
+557
+00:45:27,000 --> 00:45:32,580
+بتقدم بعد ذلك لـ CD8D-lymphocytes وهي برضه هذه
+
+558
+00:45:32,580 --> 00:45:39,600
+العملية بيسموها self MHC class 1 molecule since
+
+559
+00:45:39,600 --> 00:45:42,530
+protein are general structural complex يستخدمونه
+
+560
+00:45:42,530 --> 00:45:45,550
+لإيجار أقل واحدة بيبتايل قادرة على مجموعة MSC
+
+561
+00:45:45,550 --> 00:45:51,050
+Class I موليكيول وهذا بيأكد على أن الـ T cell
+
+562
+00:45:51,050 --> 00:45:54,890
+response is made to at least some part of a
+
+563
+00:45:54,890 --> 00:46:00,290
+foreign proantigen لأنه لا يستطيع أن يعيش أن مرتبط
+
+564
+00:46:00,290 --> 00:46:05,810
+البروتين هو عبارة عن موليكيول Complex
+
+565
+00:46:09,710 --> 00:46:15,630
+هو بتطلع لنا بيبتايد ترتبط بالـ MSC موليكيول وهذا
+
+566
+00:46:15,630 --> 00:46:20,650
+بيأكد على انه التفاعل بوادث MSC مع foreign antigen
+
+567
+00:46:20,650 --> 00:46:25,430
+أيه طبعا ان البيبتايد اللي طالعة من الـ self
+
+568
+00:46:25,430 --> 00:46:33,730
+-antigen ايضا ترتبط بالـ MSC موليكيول زي الـ foreign
+
+569
+00:46:33,730 --> 00:46:38,670
+antigen لكن الـ complex أو اما السيلف الملكولي مع
+
+570
+00:46:38,670 --> 00:46:42,570
+السيلف الابطالي لا يدفع طبق طبيعي تفعيل تفعيل T
+
+571
+00:46:42,570 --> 00:46:46,250
+cell response لأن السيلف الملكولي لا يدفع طبق
+
+572
+00:46:46,250 --> 00:46:50,810
+طبيعي كوستيميلاتري أو اتصال ثانوي لكي يدفع طبق
+
+573
+00:46:50,810 --> 00:46:53,770
+طبيعي تفعيل تفعيل T cell response الـ T cell
+
+574
+00:46:53,770 --> 00:46:57,350
+response is focused on the response of foreign فقط
+
+575
+00:46:57,350 --> 00:47:01,150
+non self particularly component of microorganism
+
+576
+00:47:01,840 --> 00:47:04,740
+وهذا هو اللي بيعمل initiation أو induction
+
+577
+00:47:04,740 --> 00:47:08,460
+للـ costimulator Susceptibility and resistance to
+
+578
+00:47:08,460 --> 00:47:12,640
+many diseases in humans and other species are
+
+579
+00:47:12,640 --> 00:47:14,700
+associated with the expression of a particular
+
+580
+00:47:14,700 --> 00:47:19,540
+MSGLD وجدوا ان هلأ اللي لاتهادي إليها علاقة مباشرة
+
+581
+00:47:19,540 --> 00:47:26,240
+بـ certain diseases و بترتبط ارتباط مباشر بهذه
+
+582
+00:47:26,240 --> 00:47:29,480
+الأمراض cytokine synthesis is a response to an
+
+583
+00:47:29,480 --> 00:47:34,110
+infectious agent طبعاً certain cytokines induce
+
+584
+00:47:34,110 --> 00:47:36,430
+their expression or regulate their expression
+
+585
+00:47:36,430 --> 00:47:39,890
+وعملت C Class I المولكول وانا اعمل C Class II
+
+586
+00:47:39,890 --> 00:47:43,390
+المولكول طبعاً هذا بيعمل enhancement ليوم ما يزيد
+
+587
+00:47:43,390 --> 00:47:48,430
+الـ titer وعمل C Class I و2 على سطح الخلية بيؤدي
+
+588
+00:47:48,430 --> 00:47:51,690
+إلى enhancement of immune response to pathogen
+
+589
+00:47:53,680 --> 00:47:57,460
+بالعكس من بعض الفيروس مثل الـ Herpes Simplex مثل
+
+590
+00:47:57,460 --> 00:48:01,080
+الـ Adenovirus مثل الـ Cytomycalovirus بعض الأحيان
+
+591
+00:48:01,080 --> 00:48:08,120
+تشتغل بروتين تتعامل بالتجارب الاندوجينوس الانتيجينية
+
+592
+00:48:08,120 --> 00:48:12,220
+ماذا تفعل في هذه الحالة؟ تفعل انهيبشن مثل الـ virus
+
+593
+00:48:12,220 --> 00:48:16,040
+يطلع بروتين يشبه الانتيجن ماشي الاندوجينوس الانتيجن
+
+594
+00:48:16,040 --> 00:48:20,460
+معناته هيمسك في الـ air في الـ MHC موليكيول وبالتالي
+
+595
+00:48:20,460 --> 00:48:25,380
+هيعمل shutdown عشان للـ immune response يعني
+
+596
+00:48:25,380 --> 00:48:32,860
+بيكوسين ينافس الـ antigen في الارتباط بالـ MHC
+
+597
+00:48:32,860 --> 00:48:37,220
+موليكيول وطبعا في هذه الحالة هذا أحد الميكانزمات
+
+598
+00:48:37,220 --> 00:48:40,360
+اللي الـ virus can decrease the expression of MHC
+
+599
+00:48:40,360 --> 00:48:44,420
+class 1 molecule and so decrease the CD8 T cell
+
+600
+00:48:44,420 --> 00:48:49,690
+response to that virus tumor cell ايضًا frequently
+
+601
+00:48:49,690 --> 00:48:52,210
+shown decrease in expression of MSC Class I ممكن
+
+602
+00:48:52,210 --> 00:48:58,130
+على سطحها في قلة في MSC Class I Titer مقارنة من
+
+603
+00:48:58,130 --> 00:49:04,770
+Normal Cell وده بيخرّمش الـ potentiality of CD8 T
+
+604
+00:49:04,770 --> 00:49:09,710
+Cell Response although the decrease in MSC Class I
+
+605
+00:49:09,710 --> 00:49:14,550
+expression decreased CD8 T Cell Response it may
+
+606
+00:49:14,550 --> 00:49:19,510
+also act as a trigger of NK يعني إذا ما اشتغلت الـ
+
+607
+00:49:19,510 --> 00:49:25,070
+cytotoxic T lymphocyte كمان هذا ممكن ينشطلنا الـ
+
+608
+00:49:25,070 --> 00:49:29,310
+NKT cell لأن زي ما شفنا يوم ما يكون الـ NKT cell
+
+609
+00:49:29,310 --> 00:49:33,970
+أو الـ response is regulated by the titer of MSC
+
+610
+00:49:33,970 --> 00:49:37,370
+molecule ففي الـ clinical cell و الـ virus infected
+
+611
+00:49:37,370 --> 00:49:40,330
+cell لما بيقلل الـ titer of MSC molecule it will be
+
+612
+00:49:40,330 --> 00:49:45,980
+recognized by mean by NK cell الـ Cross
+
+613
+00:49:45,980 --> 00:49:49,600
+-presentation هو إنها اكسوجينوس انتيجن ممكن يسموه
+
+614
+00:49:49,600 --> 00:49:53,340
+expression أو يرتبط presented by MIC class I
+
+615
+00:49:53,340 --> 00:49:57,020
+موليكيول الـ antigen presenting cell particularly
+
+616
+00:49:57,020 --> 00:50:01,260
+الـ dendritic cell لديه طريقة مميزة يسمونها cross
+
+617
+00:50:01,260 --> 00:50:05,120
+-presentation لإنشاء بيبتايد من بيبتايد اكسوجينوس
+
+618
+00:50:05,120 --> 00:50:12,280
+بروتيم وهو بيتقدم لـ CD8-T-lymphocyte هذه الطريقة
+
+619
+00:50:12,280 --> 00:50:20,710
+مهمة لإنشاء CD8-T-cell للتجارب بشكل عام بشكل عام
+
+620
+00:50:20,710 --> 00:50:23,830
+بشكل
+
+621
+00:50:23,830 --> 00:50:28,490
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+622
+00:50:28,490 --> 00:50:32,270
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+623
+00:50:32,270 --> 00:50:32,350
+عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام
+
+624
+00:50:32,350 --> 00:50:33,330
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل
+
+625
+00:50:33,330 --> 00:50:34,010
+بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل 
+
+626
+00:50:34,010 --> 00:50:38,410
+عام بشكل عام بشكل عام بشكل
+
+627
+00:50:45,290 --> 00:50:51,150
+وطبعا هذه الظاهرة بتدفعنا في حالة ما يكون في بعض
+
+628
+00:50:51,150 --> 00:50:55,970
+الviruses اللي ماتت بعملها processing by antigen 
+
+629
+00:50:55,970 --> 00:51:01,770
+presenting cell أو إذا في dying cell و برضه ما
+
+630
+00:51:01,770 --> 00:51:06,190
+بستعملها processing فبيهاجمها
+
+631
+00:51:06,190 --> 00:51:11,350
+الbare lymphocyte syndrome الناس اللي ما عندهمش
+
+632
+00:51:12,400 --> 00:51:17,760
+القدرة to express HLA Class I أو Class II molecules
+
+633
+00:51:17,760 --> 00:51:22,860
+أو التنين بالكونه ما يسمى Bare Lymphocyte Syndrome
+
+634
+00:51:22,860 --> 00:51:29,440
+والindividuals who do not express Class II molecules
+
+635
+00:51:29,440 --> 00:51:30,820
+have immunodeficiency
+
+636
+00:51:33,300 --> 00:51:36,760
+أيضا تتميز بوجود defective presentation of antigen
+
+637
+00:51:36,760 --> 00:51:41,740
+to CD4 and decreased number of CD4+ T lymphocytes
+
+638
+00:51:41,740 --> 00:51:45,560
+طبعا الناس هذوله بيكون عندهم mutation in one of
+
+639
+00:51:45,560 --> 00:51:48,920
+the factors that control transcription of MHC
+
+640
+00:51:48,920 --> 00:51:52,400
+class 2 molecule gene ما بيسمله expression
+
+641
+00:51:52,400 --> 00:51:56,340
+وبالتالي ما بيسمله إيش ال transcription وبالتالي
+
+642
+00:51:56,340 --> 00:52:00,100
+ما بيسمله اللي هو expression من أصله
+
+643
+00:52:02,670 --> 00:52:08,010
+يعني مفيك نكون أنهينا المحاضرة نرجوا أن تكونوا قد
+
+644
+00:52:08,010 --> 00:52:10,550
+استمتعتم معنا و شكرا
+
+645
+00:52:36,160 --> 00:52:36,460
+Fire
diff --git a/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/6-VZH90aeqE.srt b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/6-VZH90aeqE.srt
new file mode 100644
index 0000000000000000000000000000000000000000..e1289730b3ead3307a8011c53019ef2a07ad22ca
--- /dev/null
+++ b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/6-VZH90aeqE.srt
@@ -0,0 +1,1975 @@
+1
+00:00:21,240 --> 00:00:24,560
+بسم الله الرحمن الرحيم اليوم إن شاء الله عندنا
+
+2
+00:00:24,560 --> 00:00:29,220
+مناقشة لما سبق دراسته في chapter الأول وهو 
+
+3
+00:00:29,220 --> 00:00:33,580
+chapter الـ groups تمام؟ في عندنا مجموعة من المسائل
+
+4
+00:00:33,580 --> 00:00:37,480
+اللي طلبنا المرة اللي فاتت اتحلوها وبنتوقف عندها
+
+5
+00:00:37,480 --> 00:00:42,160
+اليوم في هذه المحاضرة إن شاء الله السؤال الأول هو
+
+6
+00:00:42,160 --> 00:00:46,040
+السؤال الخامس بيقول لي هات لي معكوس المصفوفة 2
+
+7
+00:00:46,040 --> 00:00:50,430
+6 3 5 الموجودة في الـ general linear group
+
+8
+00:00:50,430 --> 00:00:55,530
+of two by two matrices over Z11 في حاجة
+
+9
+00:00:55,530 --> 00:01:03,290
+صغيرة فيها هذا طب
+
+10
+00:01:03,290 --> 00:01:08,090
+اليوم ده خليها تطلع إن شاء الله ماشي يبقى أنا عندي
+
+11
+00:01:08,090 --> 00:01:14,630
+المصفوفة 2 6 3 5 يبقى عندي 2 اللي 
+
+12
+00:01:14,630 --> 00:01:20,210
+هو السؤال الخامس 2 6 3 5 هيك مظبوط؟
+
+13
+00:01:21,940 --> 00:01:25,940
+يبقى أنا عندي المصفوفة هذه بدنا نحاول نجيب المعكوس
+
+14
+00:01:25,940 --> 00:01:31,140
+لهذه المصفوفة مشان نجيب المعكوس لهذه المصفوفة طبعا
+
+15
+00:01:31,140 --> 00:01:35,860
+العناصر 2 6 3 5 موجودة وين في الـ Z11 دي
+
+16
+00:01:35,860 --> 00:01:40,000
+11 في الأول بدي أتأكد إن لها معكوس ولا لأ
+
+17
+00:01:40,000 --> 00:01:45,610
+فبروح بجيب مين المحدد تبع هذه المصفوفة يبقى لو جيت
+
+18
+00:01:45,610 --> 00:01:51,930
+أخذت لها determinant لـ 2 6 3 5 بده يساوي
+
+19
+00:01:51,930 --> 00:01:58,350
+3 في 5 2 في 5 بعشرة و6 في 3
+
+20
+00:01:58,350 --> 00:02:07,440
+بـ18 كل هذا الكلام modulo 11 يبقى هذا الكلام بده
+
+21
+00:02:07,440 --> 00:02:14,000
+يساوي سالب 8 modulo 11 ما عنديش حاجة
+
+22
+00:02:14,000 --> 00:02:18,700
+اسمها سالفة بروح بأضيف 11 لسالب 8 بصير
+
+23
+00:02:18,700 --> 00:02:24,800
+الجواب قد ايه؟ 3 إذا قيمة المحدد تساوي 3 لا
+
+24
+00:02:24,800 --> 00:02:31,140
+يساوي Zero إذا هنا الـ A المصفوفة هذه لها معكوس الآن
+
+25
+00:02:31,140 --> 00:02:34,460
+بدنا نجيب المعكوس أخذنا مثال الـ General Linear
+
+26
+00:02:34,460 --> 00:02:40,960
+Group of 2x2 matrices over R المعكوس تبعها 1
+
+27
+00:02:40,960 --> 00:02:45,500
+على محدد الـ A بغير عناصر القطر الرئيسي مكان بعضه
+
+28
+00:02:45,500 --> 00:02:51,560
+بغير إشارات عناصر القطر الثانوي يبقى هذا الكلام لو
+
+29
+00:02:51,560 --> 00:02:57,680
+جيت سميت المصفوفة هذه A بدي أقول له A inverse بده
+
+30
+00:02:57,680 --> 00:03:05,080
+يساوي 1/3 في المحدد في المصفوفة A 5 2 سالب
+
+31
+00:03:05,080 --> 00:03:13,670
+6 سالب 3 يبقى هذا 1/3 في الآن أنا ما عنديش سالب
+
+32
+00:03:13,670 --> 00:03:16,950
+3 أو سالب 6 يبقى بروح وبضيف لكل واحدة فيهم
+
+33
+00:03:16,950 --> 00:03:22,410
+قد ايه المقاس اللي احنا ماشيين عليه الـ 11 يبقى 5
+
+34
+00:03:22,410 --> 00:03:27,370
+هنا لو أضفت 11 بيبقى قد ايه؟ كمان 5 هنا لو أضفت
+
+35
+00:03:27,370 --> 00:03:35,520
+11 بيصير 8 وهنا 2 كل هذه عناصر موديولو 11
+
+36
+00:03:35,520 --> 00:03:39,480
+يعني 5 modulo 11 8 modulo 11 2
+
+37
+00:03:39,480 --> 00:03:44,340
+modulo 11 هل أضرب الـ 1/3 في العناصر اللي جوا
+
+38
+00:03:47,100 --> 00:03:51,760
+بتبطل يصير في Z11 الكلام مش صحيح طيب إذا شو
+
+39
+00:03:51,760 --> 00:03:57,200
+نعمل؟ بده أروح العناصر جوا أضفلها مضاعفات 11
+
+40
+00:03:57,200 --> 00:04:01,420
+بحيث كل واحد يصير فيهم يقسم على 3 هتصير
+
+41
+00:04:01,420 --> 00:04:06,600
+كلامنا صحيح إذا هذه المصفوفة لو جيت قلت what تساوي
+
+42
+00:04:06,600 --> 00:04:13,320
+هي الـ 1/3 اللي برا وهي المصفوفة لأن 11 و5 6
+
+43
+00:04:13,320 --> 00:04:18,120
+10 تقسمها 3 لأ كمان 11 و16 7
+
+44
+00:04:18,120 --> 00:04:23,640
+و20 7 27 تقسم مظبوط يبقى هذه الـ 5
+
+45
+00:04:23,640 --> 00:04:30,020
+كافة 27 مضاعفات الـ 11 تمام؟ اللي بعدها
+
+46
+00:04:30,020 --> 00:04:34,760
+زيها هاي 27 مضاعفات الـ 11 نجي للتمانية
+
+47
+00:04:34,760 --> 00:04:42,210
+11 19 9 10 وكمان 11 30 اه
+
+48
+00:04:42,210 --> 00:04:48,470
+تقسم يبقى هنا 30 وهذه 2 و11 13
+
+49
+00:04:48,470 --> 00:04:54,770
+وكمان 11 24 تقسم على 3 يبقى هذه
+
+50
+00:04:54,770 --> 00:05:01,430
+كمان 24 يبقى صارت على 3 فيها 9
+
+51
+00:05:01,430 --> 00:05:08,130
+9 وهنا فيها 10 وهنا فيها 8 الشكل عندنا
+
+52
+00:05:08,790 --> 00:05:14,450
+لاحظ إن جميع العناصر التي حصلنا عليها 9 9
+
+53
+00:05:14,450 --> 00:05:21,230
+8 10 كلها موجودة في Z11 كلها موجودة في Z11
+
+54
+00:05:21,230 --> 00:05:27,030
+الآن بدك تتأكد إن هذا الكلام صحيح فعلا هذه معكوس
+
+55
+00:05:27,030 --> 00:05:31,170
+لها دي بدنا نعمل بدنا نضرب ونستخدم الـ modulo 11
+
+56
+00:05:31,170 --> 00:05:36,520
+يبقى هذا لك في الدار براحتك تضرب المصفوفة الآن الـ
+
+57
+00:05:36,520 --> 00:05:42,400
+A A inverse بده يساوي اللي هو 2 6 3 5
+
+58
+00:05:42,400 --> 00:05:48,000
+في مين في 9 10 8 براحتك وهذا
+
+59
+00:05:48,000 --> 00:05:53,420
+الكلام لازم يطلع 1 0 0 1 ولا بصير
+
+60
+00:05:53,420 --> 00:05:57,900
+كلامنا معلق مش صحيح طب يجب إن تعملها في الدار
+
+61
+00:05:57,900 --> 00:06:02,210
+بعملك بس أول term والباقي بنفس الطريقة يبقى أنا بدي
+
+62
+00:06:02,210 --> 00:06:07,350
+أضرب 2 في 9 18 18 و6 في 10
+
+63
+00:06:07,350 --> 00:06:13,590
+بـ60 و18 78 بنشيل منهم 11
+
+64
+00:06:13,590 --> 00:06:17,130
+11 في 7 بـ77 كده اش مضال خلاص نهي
+
+65
+00:06:17,130 --> 00:06:21,050
+الـ 1 موجود وها كده عملك التاني شفوي كمان ولا
+
+66
+00:06:21,050 --> 00:06:26,030
+خلاص خلاصنا منه الصعب هذا سؤال 5 طيب هذا سؤال
+
+67
+00:06:26,030 --> 00:06:32,690
+5 سؤال 6 سؤال 6 بيقول لي give an example of
+
+68
+00:06:32,690 --> 00:06:38,270
+a group elements A و B with property that إن الـ A
+
+69
+00:06:38,270 --> 00:06:44,320
+inverse B A لا يساوي الـ B شوف يا سيدي السؤال
+
+70
+00:06:44,320 --> 00:06:48,840
+الـ 4 والسؤال الـ 6 الاثنين are the same بصراحة
+
+71
+00:06:48,840 --> 00:06:55,160
+السؤال الـ 6 صاغ بصيغة أخرى قال لك B inverse A B لا 
+
+72
+00:06:55,160 --> 00:07:01,200
+يساوي الـ B يبقى السؤال الـ 6 قال لك B inverse A B
+
+73
+00:07:01,200 --> 00:07:07,680
+لا يساوي الـ B طب أنا لو ضربت في B من جهة الشمال
+
+74
+00:07:07,680 --> 00:07:13,440
+ضربت في B من جهة الشمال B inverse A B بقى A B
+
+75
+00:07:13,440 --> 00:07:18,680
+بقى A B بقى A B بقى A B بقى A B بقى B
+
+76
+00:07:18,680 --> 00:07:21,040
+A بقى A B بقى A B بقى A B بقى A B
+
+77
+00:07:21,040 --> 00:07:23,600
+بقى A B بقى A B بقى A B بقى A B بقى
+
+78
+00:07:23,600 --> 00:07:23,740
+A بقى A B بقى A B بقى A B بقى A B
+
+79
+00:07:23,740 --> 00:07:26,580
+بقى A B بقى A B بقى A B بقى A B بقى
+
+80
+00:07:26,580 --> 00:07:36,000
+A بقى A B بقى A B بقى 
+
+81
+00:07:38,610 --> 00:07:43,530
+يعني بيقول لي هات لي مثال لـ group بحيث لو أخدت عنصرين
+
+82
+00:07:43,530 --> 00:07:47,910
+منها ضربت الـ B في A هتلاقي لا يساوي الـ A في B نفس
+
+83
+00:07:47,910 --> 00:07:52,390
+السؤال اللي هو تبع 4 بالضبط تماما جالك هات لي
+
+84
+00:07:52,390 --> 00:07:57,390
+مثال لـ non appealing group أو لـ group بحيث الـ A في
+
+85
+00:07:57,390 --> 00:08:02,050
+B لا يساوي الـ B في A يبقى 4 و6 نفس الفكرة
+
+86
+00:08:02,050 --> 00:08:10,460
+بالضبط تماما طيب مين عندك non abelian group؟ حد
+
+87
+00:08:10,460 --> 00:08:15,220
+بيقدر يجيب لي مثال؟ ممتاز جدا يبقى الـ general
+
+88
+00:08:15,220 --> 00:08:19,040
+linear group of two by two matrices over R أبسط
+
+89
+00:08:19,040 --> 00:08:27,410
+مثل نعطي كمان مثل آخر عملي؟ نعطي؟ D4 يبقى D4 مثال
+
+90
+00:08:27,410 --> 00:08:30,650
+محلول معاك والـ general linear group كمان مثال
+
+91
+00:08:30,650 --> 00:08:35,790
+محلول كفنا احنا بكفي اثنين هاي أعطيناك بدل المثال
+
+92
+00:08:35,790 --> 00:08:42,490
+اثنين يبقى كمثال على ذلك عندك D4 أو عندك كمان الـ
+
+93
+00:08:42,490 --> 00:08:45,950
+general linear group of two by two matrices over R
+
+94
+00:08:45,950 --> 00:08:51,540
+عملية ضرب المصفوفات هل هي إبدالية؟ لأ اثنين الـ D4 هل
+
+95
+00:08:51,540 --> 00:08:56,240
+هي abelian طبعا يبقى امسك أي عنصرين هات واحد مثلا
+
+96
+00:08:56,240 --> 00:08:59,240
+من الـ rotation واحد من الـ inflection واضربهم في بعض
+
+97
+00:08:59,240 --> 00:09:02,820
+واجلب طبعا حسبنا معكم الكلام هذا هتلاقي الـ A في
+
+98
+00:09:02,820 --> 00:09:06,580
+B اللي هي وساوى مين الـ B في A وهي عندك بدل المثال
+
+99
+00:09:06,580 --> 00:09:11,600
+اثنين بعد الـ 6 بدنا نروح لـ 8 8 في
+
+100
+00:09:11,600 --> 00:09:15,260
+مشكلتها ده أعداد عادية مش في مشكلة طب مين الـ
+
+101
+00:09:15,260 --> 00:09:21,460
+identity element؟ اللي قال له سؤال 8 5 و
+
+102
+00:09:21,460 --> 00:09:25,340
+20 هو الـ identity element على طول خاطر أضرب أي
+
+103
+00:09:25,340 --> 00:09:30,580
+element من الـ 6 اللي عندك اللي هو 15 و5 و
+
+104
+00:09:30,580 --> 00:09:36,160
+30 بتلاقي نفس الـ element موجود هو هو يبقى
+
+105
+00:09:36,160 --> 00:09:40,860
+الـ 25 هو الـ identity element يبقى احنا
+
+106
+00:09:40,860 --> 00:09:43,880
+عندنا الـ 5 والـ 15 والـ 25 والـ 5
+
+107
+00:09:43,880 --> 00:09:48,720
+و30 أربعة عناصر عنصر الوحدة فيهم هو 5 و
+
+108
+00:09:48,720 --> 00:09:53,080
+20 طبعا modulo 40 يعني المقاس اللي احنا
+
+109
+00:09:53,080 --> 00:09:58,340
+ماشيين فيه اللي هو مين اللي هو الـ 40 طيب نيجي لسؤال
+
+110
+00:09:58,340 --> 00:10:05,340
+الآن 10 سؤال 10 ما طيني two sets الـ set الأولى
+
+111
+00:10:07,720 --> 00:10:13,960
+سؤال 10 بيقول list the elements of H بدها تساوي
+
+112
+00:10:13,960 --> 00:10:22,520
+كل العناصر X تربيع بحيث الـ X موجودة في D4 وكذلك
+
+113
+00:10:22,520 --> 00:10:29,700
+الـ set التانية لكابيتال K لكل العناصر X اللي موجودة في
+
+114
+00:10:29,700 --> 00:10:39,410
+D4 بحيث إن X² is equal to the identity element يبقى
+
+115
+00:10:39,410 --> 00:10:45,730
+أمامنا احنا سؤالين كل سؤال بدنا نحسبه على حدة الآن
+
+116
+00:10:45,730 --> 00:10:53,050
+لما نيجي لـ D4 الـ D4 العناصر تبعها R0 وR90
+
+117
+00:10:53,050 --> 00:11:00,750
+وR180 وR270 والـ H والـ V والـ
+
+118
+00:11:00,750 --> 00:11:06,240
+D والـ D prime يبقى هاي الثمان عناصر تبعها بدنا
+
+119
+00:11:06,240 --> 00:11:12,160
+نيجي نحسبه الـ set الأولى من H كل العناصر X تربيع
+
+120
+00:11:12,160 --> 00:11:17,660
+بحيث الـ X موجودة في D يعني ايه؟ بدأ أخد عنصر من D4
+
+121
+00:11:17,660 --> 00:11:22,820
+وأروح أربعه والنتج أحطه في مين؟ في هذه الـ set يبقى
+
+122
+00:11:22,820 --> 00:11:28,820
+بناء عليه الـ H بدها تساوي بدأ أمسك R0 لو ربعته
+
+123
+00:11:28,820 --> 00:11:33,670
+من بيطلع R0 نفسه يبقى R0 موجود في هذه
+
+124
+00:11:33,670 --> 00:11:38,970
+المجموعة بالداخل الـ R90 لو ربعته شو بيطلع R
+
+125
+00:11:38,970 --> 00:11:44,850
+180 يبقى R180 بالداخل الـ R180
+
+126
+00:11:44,850 --> 00:11:49,110
+و 80 لو ربعتها R40 موجودة يبقى بسيبها
+
+127
+00:11:49,110 --> 00:11:53,170
+بالداخل الـ R40 و 70 لو ربعتها 
+
+128
+00:11:55,600 --> 00:12:01,440
+R كده؟ 180 يعني بصير R 270 500 و
+
+129
+00:12:01,440 --> 00:12:05,320
+40 شيل منهم الدورة الكاملة اللي هي 360 و
+
+130
+00:12:05,320 --> 00:12:11,700
+60 بيضل 180 هي موجودة يبقى هذه كمان 
+
+131
+00:12:11,700 --> 00:12:17,260
+ضالة موجودة طب ده رابع الـ H تربيع الـ identity are
+
+132
+00:12:17,260 --> 00:12:24,210
+not هي موجودة R40 R40 R40 R40
+
+133
+00:12:24,210 --> 00:12:30,050
+R40 R40 R40 R40 R40 R40 R40 R40
+
+134
+00:12:30,050 --> 00:12:30,290
+R40 R40 R40 R40 R40 R40 R40 R40
+
+135
+00:12:30,290 --> 00:12:31,350
+R40 R40 R40 R40 R40 R40 R40 R40
+
+136
+00:12:31,350 --> 00:12:39,570
+R40 R40 R40 R40 R40 R40 R40 R40
+
+137
+00:12:39,570 --> 00:12:45,320
+الـ K بده يساوي كل العناصر اللي فيه D4 لما
+
+138
+00:12:45,320 --> 00:12:49,920
+ربيعها بده يعطينا الـ identity كتبنا هلكم كتبنا
+
+139
+00:12:49,920 --> 00:12:54,600
+R180 تربيع بقداش؟ بالـ identity و R40 تربيع و الـ V
+
+140
+00:12:54,600 --> 00:12:57,120
+تربيع و الـ D تربيع و الـ D' تربيع كله بالـ
+
+141
+00:12:57,120 --> 00:13:05,960
+identity إذا عناصر الـ Kالرقم الرابع يبقى الـ
+
+142
+00:13:05,960 --> 00:13:14,640
+identity نفسه الـ identity الـ R40 الـ R
+
+143
+00:13:14,640 --> 00:13:17,800
+90
+
+144
+00:13:17,800 --> 00:13:25,130
+الـ R80 يبقى الـ R180 تعطينا الـ
+
+145
+00:13:25,130 --> 00:13:29,010
+identity الـ R270 لو ربعتها بتعطينا ايه؟
+
+146
+00:13:29,010 --> 00:13:34,750
+بتعطينا الـ 180 اللي بعدها الـ H و الـ V و الـ
+
+147
+00:13:34,750 --> 00:13:39,470
+D و الـ D' كلها هذه لو ربعتها بتعطينا مية؟ الـ
+
+148
+00:13:39,470 --> 00:13:44,150
+identity element يبقى هذا بالنسبة لسؤال 10
+
+149
+00:13:44,150 --> 00:13:46,450
+بالنسبة لسؤال 12
+
+150
+00:13:50,380 --> 00:13:55,380
+12 بيقول لي for any integer n greater than or
+
+151
+00:13:55,380 --> 00:13:58,540
+equal to 2 show that there are at least two
+
+152
+00:13:58,540 --> 00:14:04,880
+elements in U N such that ال .. such that اللي هو
+
+153
+00:14:04,880 --> 00:14:08,960
+satisfy الـ X تربيع بده يسمى main الـ identity
+
+154
+00:14:08,960 --> 00:14:19,680
+element لو جيت الآن للـ U N عناصرها 1 و كداش
+
+155
+00:14:19,680 --> 00:14:27,340
+آخر عنصر ناقص 1 تمام يبقى هذا العنصر الأخير
+
+156
+00:14:27,340 --> 00:14:38,060
+في الـ group بيقول يبين ليهذا المعادل يحقق
+
+157
+00:14:38,060 --> 00:14:43,780
+على أقل اتنين يحققوا المعادلة X تربيع تساوي 1
+
+158
+00:14:43,780 --> 00:14:49,880
+يعني مربع العنصر الـ identity element طبعا ممكن أقل
+
+159
+00:14:49,880 --> 00:14:53,400
+حاجة فيها 2 لكن ممكن يكون فيها 4 ممكن يكون
+
+160
+00:14:53,400 --> 00:14:57,540
+فيها 6 ممكن ممكن إلى آخره تمام طيب احنا بدنا
+
+161
+00:14:57,540 --> 00:15:03,760
+نيجي نشوف هل هذه الـ group فيها two elements لو
+
+162
+00:15:03,760 --> 00:15:09,300
+ربعتهم بيعطينا الـ identity element ولا لا الـ 1
+
+163
+00:15:09,300 --> 00:15:12,220
+مربع بـ 1 يبقى 1 فيهم التاني
+
+164
+00:15:17,630 --> 00:15:23,590
+الآن ادعى ان العنصرين اللي بحققوا المعادلة x
+
+165
+00:15:23,590 --> 00:15:30,610
+تربيها تساوي 1 هما الست التالية 1 و N ناقص
+
+166
+00:15:30,610 --> 00:15:34,930
+1 ممكن يكون في غيرهم هه بس هو ايش بيقول لي بيقول لي
+
+167
+00:15:34,930 --> 00:15:39,680
+اثبت انه على الأقل عندي 2 بقول الآن أنا هذول
+
+168
+00:15:39,680 --> 00:15:45,240
+ليش؟ because السبب ان هذول هم اللي بيحقوا المعادلة
+
+169
+00:15:45,240 --> 00:15:51,660
+الـ 1 تربيع شو بيعطيني؟ الـ 1 it's الـ and N ناقص
+
+170
+00:15:51,660 --> 00:15:55,260
+1 لكل تربيع هذا لازم يعطينا الـ identity اللي هو
+
+171
+00:15:55,260 --> 00:16:01,880
+مين؟ 1 طيب هذا لو ربعته بيصير N تربيع ناقص
+
+172
+00:16:01,880 --> 00:16:09,990
+2 N زائد 1 هذا الكلام كله ايه؟ كله مضاعف الـ N
+
+173
+00:16:09,990 --> 00:16:15,870
+تمام يعني كل الـ N هذي بده يشيلها طيب هذي N تربيع
+
+174
+00:16:15,870 --> 00:16:22,210
+باعتبارها قداش؟ 0 سالب 2 N كمان 0 لإن كل
+
+175
+00:16:22,210 --> 00:16:27,350
+N بده كده تحذفها ومضاعفها تقدرش بيضل عندنا بيضل
+
+176
+00:16:27,350 --> 00:16:32,730
+اللي هو الـ 1 يبقى بناء عليه عند العنصرين هدول هم
+
+177
+00:16:32,730 --> 00:16:40,930
+اللذان يحققان هذه المعادلة طيب هذا سؤال 12 بعده
+
+178
+00:16:40,930 --> 00:16:47,750
+بروح لسؤال 17 مش هيك؟ سؤال 17 نمسح الناحية
+
+179
+00:16:47,750 --> 00:16:48,190
+هذه
+
+180
+00:17:03,160 --> 00:17:08,180
+السؤال 17 بيقول ما يلي إن G أبيليان if
+
+181
+00:17:08,180 --> 00:17:16,600
+and only if السؤال 17 G أبيليان if and
+
+182
+00:17:16,600 --> 00:17:24,880
+only if اللي هو من الـ (a b) الكل inverse الـ (a b) الكل
+
+183
+00:17:24,880 --> 00:17:30,940
+inverse بده يساوي الـ a inverse
+
+184
+00:17:43,130 --> 00:17:48,900
+البرهان هذا بيصير في اتجاهين يبقى أنا الاتجاه الأول
+
+185
+00:17:48,900 --> 00:17:55,460
+بدي اجي اقوله افرض ان الـ G .. والله assume ..
+
+186
+00:17:55,460 --> 00:18:01,160
+assume that ان الـ G is abelian
+
+187
+00:18:05,580 --> 00:18:10,120
+مدام أبيليان بدي اثبت ايش؟ بدي اثبت انه (a b) لكل
+
+188
+00:18:10,120 --> 00:18:14,320
+inverse بدي يساوي a inverse b inverse لكن احنا
+
+189
+00:18:14,320 --> 00:18:19,860
+اثبتنا سابقا ان الـ (a b) لكل inverse يسوي b inverse
+
+190
+00:18:19,860 --> 00:18:25,120
+a inverse يبقى هذا الكلام باجي بقوله الـ (a b)
+
+191
+00:18:25,120 --> 00:18:32,620
+inverse بدي يسوي اللي هو b inverse a inverse مظبوط
+
+192
+00:18:33,120 --> 00:18:37,640
+لكن هو ايش قال لي G مالها؟ يبقى بقدر ابدل زي ما
+
+193
+00:18:37,640 --> 00:18:41,800
+أنا عايزه مالوش كلام عندي يبقى هنا هذا الكلام بده
+
+194
+00:18:41,800 --> 00:18:48,580
+يساوي a inverse b inverse ليش؟ because السبب ان الـ
+
+195
+00:18:48,580 --> 00:18:57,180
+G is abelian يبقى اثبتنا الاتجاه الأول بده اروح
+
+196
+00:18:57,180 --> 00:19:00,800
+الآن لمن؟ للاتجاه الثاني
+
+197
+00:19:07,570 --> 00:19:14,170
+الآن بجيب اقوله conversely assume
+
+198
+00:19:14,170 --> 00:19:23,850
+افترض ان الـ (a b) لكل inverse بدي يساوي a inverse b
+
+199
+00:19:23,850 --> 00:19:32,150
+inverse بدي اثبتله ايش؟ ليه قابله طيب بدي اقوله
+
+200
+00:19:32,150 --> 00:19:38,940
+consider خدلي يعني بدي أثبت أن الـ A في B بدي أثبت
+
+201
+00:19:38,940 --> 00:19:46,280
+B في A لكل الـ A و B اللي موجودة في G consider A
+
+202
+00:19:46,280 --> 00:19:59,180
+و B any elements أي عناصر in G طيب
+
+203
+00:19:59,180 --> 00:20:08,620
+لو أخدت الآن الـ (A B) الكل inverse ايش بيساوي؟ بده
+
+204
+00:20:08,620 --> 00:20:16,640
+يساوي A inverse B inverse طيب لو روحت ضربت في
+
+205
+00:20:16,640 --> 00:20:26,880
+الطرفين من جهة الشمال في BA يعني صار BA في الـ (A B)
+
+206
+00:20:26,880 --> 00:20:36,520
+inverse بده يساوي الـ B في A في الـ A inverse في الـ B
+
+207
+00:20:36,520 --> 00:20:42,120
+inverse ضربت الطرفين من جهة الشمال في الـ B ايه
+
+208
+00:20:42,120 --> 00:20:47,920
+اللي أنا لازمالي هذه بدوش أتلاعب فيها طيب هدفي هدى
+
+209
+00:20:47,920 --> 00:20:55,140
+كده بيعطينا يعني هدى B E B inverse اللي بده يساوي B
+
+210
+00:20:55,140 --> 00:21:00,520
+B inverse بده يساوي الـ identity طب أنا بده أخلك في
+
+211
+00:21:00,520 --> 00:21:07,210
+المسألة A B يبقى بإمكاني ضرب الطرفين في A B إذا
+
+212
+00:21:07,210 --> 00:21:17,090
+ضربت الطرفين في A B بصير BA في (A B) Inverse في A B
+
+213
+00:21:17,090 --> 00:21:24,230
+بدي يساوي الـ E في الـ A B يبقى بيه اللي ايه مكتسبات
+
+214
+00:21:24,230 --> 00:21:29,170
+وطنية حفظنا عليها مالعبناش فيها هذه ايه؟ بده اشلج
+
+215
+00:21:29,170 --> 00:21:34,490
+فيها a و b فاروح الطرفين المعادلة في الـ element a
+
+216
+00:21:34,490 --> 00:21:40,590
+و b طب ايه رأيك هذا العنصر و هذا؟ مش 1 معكوس
+
+217
+00:21:40,590 --> 00:21:46,810
+التاني يبقى حاصل ضربهما بالـ identity element يبقى
+
+218
+00:21:46,810 --> 00:21:53,510
+السعر عندي B في A في الـ identity element بدي يساوي
+
+219
+00:21:53,510 --> 00:21:59,490
+الـ identity element في a,b طب الـ identity element
+
+220
+00:21:59,490 --> 00:22:04,330
+لما تضرب في أي element تطلع من نفس الـ element يبقى
+
+221
+00:22:04,330 --> 00:22:13,590
+B في A بدي يساوي A في B في عندي قيود على A و B؟ أي
+
+222
+00:22:13,590 --> 00:22:17,630
+عناصر في G يبقى بنان عليه مالها؟ G is abelian
+
+223
+00:22:17,630 --> 00:22:24,150
+يبقى هنا إذن G is abelian
+
+224
+00:22:29,980 --> 00:22:39,120
+هذا سؤال 17 سؤال سؤال سؤال 18 هذا حلناه
+
+225
+00:22:39,120 --> 00:22:44,740
+في المحاضرة أخدناه كمثال طيب سؤال 19 بيقول لي
+
+226
+00:22:44,740 --> 00:22:51,420
+لأي element a و b من group G and any integer n
+
+227
+00:22:51,420 --> 00:22:57,390
+prove that ثم اثبت أن
+
+228
+00:22:57,390 --> 00:23:06,910
+الـ a inverse b a to
+
+229
+00:23:06,910 --> 00:23:17,230
+the power n يساوي a inverse b in a و الـ n هذا is an
+
+230
+00:23:17,230 --> 00:23:17,950
+integer
+
+231
+00:23:20,710 --> 00:23:26,430
+قال يثبت أن الطرفين هدول متساوين حد فيكوا حل هذا
+
+232
+00:23:26,430 --> 00:23:33,050
+السؤال؟ و لو نص حل يعني بالـ induction بس الـ
+
+233
+00:23:33,050 --> 00:23:40,680
+induction اللي اتعلمناه على عدد صحيح موجب صح؟ سكت
+
+234
+00:23:40,680 --> 00:23:45,380
+الشعور مش شكيت في المبادئ أخدنا الـ induction على إن
+
+235
+00:23:45,380 --> 00:23:49,900
+عدد صحيح موجب طيب نشوف بدنا نروح نستخدم الـ
+
+236
+00:23:49,900 --> 00:23:53,580
+induction و نشوف هل الكلام هذا صحيح ولا لأ بس هنا
+
+237
+00:23:53,580 --> 00:23:58,110
+جالي انتجاري يعني انت بدك تحسبه للموجب والسالب
+
+238
+00:23:58,110 --> 00:24:01,790
+والصفر في أحد يقول كلامك صحيح لكن لو قال لي n
+
+239
+00:24:01,790 --> 00:24:06,230
+positive integer بستخدم الـ induction مباشرة تبع
+
+240
+00:24:06,230 --> 00:24:11,750
+مبادئ الرياضيات وبوصل للنتيجة تمام بداجي اقول هنا
+
+241
+00:24:11,750 --> 00:24:20,690
+solution لو كانت الـ n بـ 0 if الـ n تساوي 0
+
+242
+00:24:20,690 --> 00:24:26,740
+then العلاقة هذه صحيحة ولا لأ تعالى نشوف أي عدد
+
+243
+00:24:26,740 --> 00:24:33,100
+مرفوع للـ 0 بكام؟ بالـ identity يبقى الـ E يبقى A
+
+244
+00:24:33,100 --> 00:24:41,490
+inverse بـ 0 بالـ identity في A معناته ايش؟ ان الـ E
+
+245
+00:24:41,490 --> 00:24:46,950
+بده يساوي الـ A inverse A يبقى الـ E بده يساوي الـ E
+
+246
+00:24:46,950 --> 00:24:51,290
+يبقى الـ statement صحيحة يبقى باجي بقول هذا بده
+
+247
+00:24:51,290 --> 00:25:02,570
+يعطينا ان the statement hold صحيحة طيب لو كانت الـ
+
+248
+00:25:02,570 --> 00:25:16,460
+N بـ 1 if الـ N تساوي 1 then the statement برضه
+
+249
+00:25:16,460 --> 00:25:17,580
+hold ولا لا؟
+
+250
+00:25:29,880 --> 00:25:37,560
+أفترض أنها صحيحة عند N تساوي K و أثبت صحتها عند N
+
+251
+00:25:37,560 --> 00:25:42,860
+تساوي K زائد واحد يبقى هنا ماجي بداجي أقول له
+
+252
+00:25:42,860 --> 00:25:46,880
+assume that
+
+253
+00:25:47,930 --> 00:25:55,910
+إن الـ a inverse b a to the power k بدي أسوي a
+
+254
+00:25:55,910 --> 00:26:05,450
+inverse b<sup>k</sup>  و ال k أكبر من الواحد كمان و ال k
+
+255
+00:26:05,450 --> 00:26:14,470
+integer أكبر من الواحد هذا ال k integer and ال k 
+
+256
+00:26:14,470 --> 00:26:19,180
+greater than one طيب تمام
+
+257
+00:26:22,700 --> 00:26:28,420
+بدي أحاول أثبت صحة هذا الموضوع عند K زائد واحد يبقى
+
+258
+00:26:28,420 --> 00:26:35,520
+باجي بقوله consider خدلي a inverse ba to the power
+
+259
+00:26:35,520 --> 00:26:41,940
+k plus one انطلع الناتج a inverse b<sup>k+1</sup> في a
+
+260
+00:26:41,940 --> 00:26:48,180
+بصير كلامنا معله صحيح يبقى هذا الكلام بده يساوي a
+
+261
+00:26:48,180 --> 00:26:51,500
+inverse ba في k
+
+262
+00:27:00,590 --> 00:27:11,330
+هذا الكلام أنا فارضه هنا يبقى a inverse b to the
+
+263
+00:27:11,330 --> 00:27:18,790
+power of k a في من في ال a inverse ب a جبته من وين
+
+264
+00:27:18,790 --> 00:27:25,590
+from assumption من الفرض اللي أنا فرضه مش جايبه من
+
+265
+00:27:25,590 --> 00:27:31,650
+كيسي أنا فرضه ان هو صحيح طيب تعالوا تطلعوا لهدول
+
+266
+00:27:31,650 --> 00:27:37,920
+هدول بقداش ال a في ال a inverse بالـ identity
+
+267
+00:27:37,920 --> 00:27:45,020
+element يبقى هذا الكلام بيساوي A inverse b<sup>k</sup> في
+
+268
+00:27:45,020 --> 00:27:52,340
+ال E في ال بي A ال identity element اضرب في أي
+
+269
+00:27:52,340 --> 00:27:58,100
+element بيطلع نفس ال element يبقى هذا A inverse b
+
+270
+00:27:58,100 --> 00:28:06,640
+<sup>k</sup> في ال بي A الـ B و الـ b<sup>k</sup> مش همارا b<sup>k+1</sup>
+
+271
+00:28:06,640 --> 00:28:14,540
+يبقى هنا A inverse b<sup>k+1</sup> في من؟ في الـ A
+
+272
+00:28:14,540 --> 00:28:20,260
+يبقى صارت ال statement مالها صحيحة هنا هذا بدي
+
+273
+00:28:20,260 --> 00:28:28,300
+يعطينا ال statement الجملة اللي عندنا hold ايش
+
+274
+00:28:28,300 --> 00:28:29,480
+ضايق عندنا؟
+
+275
+00:28:34,110 --> 00:28:43,270
+إذا كان الـ N أقل من Zero فأنا
+
+276
+00:28:43,270 --> 00:28:43,990
+بقدر أخليها موجب
+
+277
+00:28:47,900 --> 00:28:53,800
+يجب أن اضرب في قداش السالب يبقى السالب n بدها
+
+278
+00:28:53,800 --> 00:28:58,780
+تصير أكبر من ال zero لما تبقى ال n سالبة اضربها
+
+279
+00:28:58,780 --> 00:29:05,800
+في كمان سالبة تصير موجبة مظبوط طيب خد هنا المطلوب
+
+280
+00:29:05,800 --> 00:29:12,800
+اللي هو ال a inverse b a equal to the power n لو
+
+281
+00:29:12,800 --> 00:29:17,840
+ضربت يا شباب في الـ A inverse بـ A to the power
+
+282
+00:29:17,840 --> 00:29:24,940
+minus ال N كده بيطلع ال identity؟ لأنه بصير ال
+
+283
+00:29:24,940 --> 00:29:30,780
+element أُس Zero يبقى هذا يعطينا ال identity
+
+284
+00:29:30,780 --> 00:29:40,880
+element طيب هذا معناه إيش؟ معناه أن ال A inverse b
+
+285
+00:29:40,880 --> 00:29:48,960
+a to the power n بده يساوي a inverse b to the
+
+286
+00:29:48,960 --> 00:29:56,540
+minus n a هذا يعني هذا في هذا مش يساوي هذا في هذا
+
+287
+00:29:56,540 --> 00:30:02,720
+بده يعطينا ال identity صح هي الكلامي صح ولا غلط
+
+288
+00:30:02,720 --> 00:30:10,950
+هذا صح ليش لأن ناقص n أكبر من zero و احنا هنا لما
+
+289
+00:30:10,950 --> 00:30:14,470
+تبقى ال n أكبر من zero اثبتنا ال statement مالها
+
+290
+00:30:14,470 --> 00:30:24,910
+صحيحة يبقى this is a true because السبب ان ناقص n
+
+291
+00:30:24,910 --> 00:30:30,180
+greater than zero لأن المبرهنها هي فوق مشان هيك
+
+292
+00:30:30,180 --> 00:30:34,120
+صارت العبارة اللي عندها دي مالها صحيحة طب إيش
+
+293
+00:30:34,120 --> 00:30:39,740
+رايك؟ بدي أضرب في معكوس هذا العنصر و أشوف وين
+
+294
+00:30:39,740 --> 00:30:45,180
+بتودي الدنيا يبقى لو ضربت في معكوس هذا العنصر بصير
+
+295
+00:30:45,180 --> 00:30:52,520
+a inverse b a to the power n فاهمين؟ في ال a
+
+296
+00:30:52,520 --> 00:31:03,570
+inverse b to the minus n A كل هذا A في ال A inverse
+
+297
+00:31:03,570 --> 00:31:12,350
+b<sup>-n</sup> A inverse بده يساوي طرف اليمين E في
+
+298
+00:31:12,350 --> 00:31:19,310
+main في ال A inverse b<sup>-1</sup> A inverse
+
+299
+00:31:22,020 --> 00:31:27,320
+هذه المعادلة وصلت لها ضربت الطرفين في معكوس هذا
+
+300
+00:31:27,320 --> 00:31:33,020
+العنصر يبقى هي العنصر الأول هي الثاني هي معكوس
+
+301
+00:31:33,020 --> 00:31:37,360
+التاني حطيت ال inverse فوق يبقى هذا شو بده يعطيني
+
+302
+00:31:37,360 --> 00:31:42,440
+العنصر في معكسه ايش بيعطيني ال identity element في
+
+303
+00:31:42,440 --> 00:31:48,060
+اللي جابله نفس ال element يبقى الطرف الشمال بصير a
+
+304
+00:31:48,060 --> 00:31:56,900
+inverse b كله to the power n بده يساوي ال identity
+
+305
+00:31:56,900 --> 00:32:01,680
+element في العنصر بده يعطينا نفس العنصر يبقى هذا
+
+306
+00:32:01,680 --> 00:32:08,720
+بده يعطينا a inverse b<sup>-n</sup> صلح ليها b<sup>-n</sup>
+
+307
+00:32:08,720 --> 00:32:17,800
+نضرب نهاية هنا يبقى a inverse b<sup>-n</sup> a كله
+
+308
+00:32:17,800 --> 00:32:18,380
+inverse
+
+309
+00:32:20,890 --> 00:32:26,990
+طيب هرجعلي هذه خدلي في الهامش لما اقول a b inverse
+
+310
+00:32:26,990 --> 00:32:33,030
+ايه يا شباب كده ايش تساوي b inverse a inverse طب لو
+
+311
+00:32:33,030 --> 00:32:40,290
+قلت a b c inverse ايش بتساوي c inverse b inverse
+
+312
+00:32:40,290 --> 00:32:44,910
+a inverse تمام هطبق هذا الكلام هنا يبقى هذا ايش
+
+313
+00:32:44,910 --> 00:32:54,410
+هيعطيلك هذا سيعطيك a inverse وهنا b<sup>-n</sup> كله
+
+314
+00:32:54,410 --> 00:33:01,570
+inverse وهذا سيعطيك الهمين a inverse inverse
+
+315
+00:33:04,680 --> 00:33:09,940
+يبقى هذا الكلام بده يساوي هذي ال a inverse كما هي
+
+316
+00:33:09,940 --> 00:33:15,840
+و هذي الأسس تضرب في بعضها ضرب -n في -1
+
+317
+00:33:15,840 --> 00:33:22,580
+بيطلع جديش اللي هو b<sup>n</sup> و a inverse inverse هي
+
+318
+00:33:22,580 --> 00:33:28,230
+ال element a يبقى صحيحة برضه في حالة السالب ولا لا
+
+319
+00:33:28,230 --> 00:33:36,330
+إذا صحيحة للكل يبقى أثبتناها لل zero و للواحد و
+
+320
+00:33:36,330 --> 00:33:41,550
+للموجب و السالب إذا هي صحيحة ل any integer بعد ذلك
+
+321
+00:33:41,550 --> 00:33:47,210
+حد بيحب يسأل أي سؤال هنا السؤال فكرته جيدة كتير
+
+322
+00:33:47,210 --> 00:33:52,890
+الحقيقة لأن الدرجة اللي متعرف عليه اللي فيه مبادئ
+
+323
+00:33:52,890 --> 00:33:58,090
+الرياضيات نستخدم ال induction لعدد الصحيح الموجب
+
+324
+00:33:58,090 --> 00:34:03,170
+لكن استخدمنا للموجب والسالب وطلعنا نتيجة صحيحة في
+
+325
+00:34:03,170 --> 00:34:12,620
+كل حالة هذا كان سؤال تسعة عشر الآن بعد تسعة عشر عنا
+
+326
+00:34:12,620 --> 00:34:17,400
+مين عنا سؤال أربعة و عشرين ب deconstruct K ليه
+
+327
+00:34:17,400 --> 00:34:22,300
+تابل ليه و اتناشر كلمة K ليه تابل جديدة على ما
+
+328
+00:34:22,300 --> 00:34:26,780
+سامعنا جداش قولنا الحين السؤال أربعة و عشرين
+
+329
+00:34:26,780 --> 00:34:30,600
+بالنسبالي الهامشة سواء كان تبديل أو غير تبديل
+
+330
+00:34:30,600 --> 00:34:34,260
+الصحيح بالجملة اللي هي مين اللي في الهامش و ده
+
+331
+00:34:34,260 --> 00:34:34,900
+اللي في الهامش
+
+332
+00:34:38,020 --> 00:34:45,100
+هذه non abelian group لا لو كانت abelian بدل زي ما
+
+333
+00:34:45,100 --> 00:34:49,840
+بدها بس non abelian بيبقى ترتيب الآخر الثاني الأول
+
+334
+00:34:49,840 --> 00:34:54,480
+هاي الآخر الثاني الأول نقلب الوضع سباحة مقدمة مش
+
+335
+00:34:54,480 --> 00:34:56,920
+تلاتة إن شاء الله يكونوا عشرين ببدأ من ال عشرين
+
+336
+00:34:56,920 --> 00:35:02,880
+تسعة عشر ثمانية عشر الآخرين نجي الآن لسؤال أربعة و
+
+337
+00:35:02,880 --> 00:35:08,980
+عشرين بدي K تابل لليو اتناشر يبقى هذه ال U 12
+
+338
+00:35:08,980 --> 00:35:15,340
+اللي عناصرها الواحد اتنين تلاتة أربعة خمسة ستة
+
+339
+00:35:15,340 --> 00:35:21,640
+سبعة ثمانية تسعة عشر أحد عشر تمام؟ لما يقول ال K
+
+340
+00:35:21,640 --> 00:35:25,080
+لي ال table يعني بدي اضرب العناصر في بعض وشوف كيف
+
+341
+00:35:25,080 --> 00:35:31,520
+النتيجة فباجي بقوله هذا الجدول وبعدين بحط العناصر
+
+342
+00:35:31,520 --> 00:35:38,720
+واحد خمسة سبعة أحد عشر و هنا واحد خمسة سبعة أحد عشر
+
+343
+00:35:38,720 --> 00:35:45,140
+و بعدين بجسمها إلى جدول بهذا الشكل و هنا بشتغل
+
+344
+00:35:45,140 --> 00:35:50,640
+أفقي بالشكل اللي عندنا هذا و بعدين أعبي هذا الجدول
+
+345
+00:35:50,640 --> 00:36:01,380
+تمام؟ الآن هنا ده كله العملية module 12 الآن العنصر
+
+346
+00:36:01,380 --> 00:36:04,280
+الوحيد اللي مانتظره في أي عنصر بيطلع نفس العنصر
+
+347
+00:36:12,890 --> 00:36:16,810
+كيف هذه؟ واحد في واحد بواحد، واحد في خمسة بخمسة،
+
+348
+00:36:16,810 --> 00:36:19,910
+واحد في سبعة بسبعة، واحد في أحد عشر بأحد عشر،
+
+349
+00:36:19,910 --> 00:36:23,990
+العنصر ده رأسي، واحد في واحد بواحد، واحد في خمسة
+
+350
+00:36:23,990 --> 00:36:27,690
+بخمسة، واحد في سبعة بسبعة، واحد في أحد عشر بأحد عشر،
+
+351
+00:36:27,690 --> 00:36:31,350
+طبعا هذه ال group أبدالية وبالتالي يمين ومول وشمال
+
+352
+00:36:31,350 --> 00:36:35,150
+ما تفرقش عننا، بعدين تجيب العناصر هنا، هذا من؟ هو
+
+353
+00:36:35,150 --> 00:36:41,210
+عبارة عن خمسة في خمسة، خمسة في خمسة، خمسة وعشرين،
+
+354
+00:36:41,210 --> 00:36:48,370
+تمام؟ موديولو اتناش اه اللي هو واحد تمام؟ الآن خمسة
+
+355
+00:36:48,370 --> 00:36:54,150
+في سبعة بخمسة و تلاتين موديولو اتناش اللي هو
+
+356
+00:36:54,150 --> 00:37:00,210
+الأحد عشر الآن خمسة في أحد عشر بخمسة و خمسين موديولو
+
+357
+00:37:00,210 --> 00:37:05,750
+أحد عشر اللي هو كده؟ سبعة بالشكل اللي أنا انام ممنوع
+
+358
+00:37:05,750 --> 00:37:10,710
+الرقم يتكرر مرتين في نفس الصف يعني الخط هذا و
+
+359
+00:37:10,710 --> 00:37:15,690
+الخط الثاني اللي جوا هذا ممنوع يتكرر الرقم إلا مرة
+
+360
+00:37:15,690 --> 00:37:19,850
+واحدة امسك خمسة واحد أحد عشر سبعة هما العناصر من
+
+361
+00:37:19,850 --> 00:37:24,530
+اللي فوق و هكذا الآن سبعة في واحدة سبعة سبعة في
+
+362
+00:37:24,530 --> 00:37:31,350
+خمسة خمسة و تلاتين خمسة و تلاتين بصير عند إيش اللي
+
+363
+00:37:31,350 --> 00:37:34,980
+هو أحد عشر اللي بعده سبعة في سبعة بتسعة و أربعين
+
+364
+00:37:34,980 --> 00:37:37,880
+أربعة في اتناشر تسعة و أربعين و يبقى له واحد الآن
+
+365
+00:37:37,880 --> 00:37:42,660
+وأني مغمط بقدر أحط الرقم بدون محسب الرقم اللي ضايل
+
+366
+00:37:42,660 --> 00:37:47,160
+طبعا الآن لو جيت أحد عشر واحد أحد عشر في خمسة خمسة
+
+367
+00:37:47,160 --> 00:37:53,100
+و خمسين اللي هو السبعة أحد عشر في سبعة بسبعة وسبعين
+
+368
+00:37:53,100 --> 00:37:59,780
+سبعة وسبعين يعني كده إيش بيطلع ستة أربعة بيطلع
+
+369
+00:37:59,780 --> 00:38:06,160
+واحد من هدول يا راجل يبقى خمسة ضل الغايب اللي هو
+
+370
+00:38:06,160 --> 00:38:09,520
+العنصر اللي هو الواحد تمام يبقى هيك بنشتغل بالجدول
+
+371
+00:38:09,520 --> 00:38:14,000
+الكلام اللي سمعته بده أطبقه على السؤال اللي بعده
+
+372
+00:38:14,000 --> 00:38:18,680
+ونشوف هذا سهل علشانها أرقام سهلة يعني سهل الشغل
+
+373
+00:38:18,680 --> 00:38:25,300
+فيها تماما الآن في عندك ال table جاهزة بس بالرموز
+
+374
+00:38:25,300 --> 00:38:28,860
+بده أشوف كيف تعبولي هذه الرموز
+
+375
+00:38:41,310 --> 00:38:47,930
+الآن سؤال خمسة و عشرين برضه جدول الشكل اللي عندنا 
+
+376
+00:38:47,930 --> 00:39:00,390
+هنا الجدول ميعطيني E و A B C D E و A B C D تمام و
+
+377
+00:39:00,390 --> 00:39:06,730
+قسمها بالشكل اللي عندنا هذا وهيقفلنا الجدول وهنا 
+
+378
+00:39:06,730 --> 00:39:21,050
+E وهنا A وهنا B وهنا C وهنا D وراح أبالي في
+
+379
+00:39:21,050 --> 00:39:30,110
+الجدول حطلي هنا E وتاني حطلي هنا B  وجبال A حطلي B
+
+380
+00:39:30,110 --> 00:39:44,370
+وعند ال B حط C D E C D E C D E و جبال SC حطلي D و
+
+381
+00:39:44,370 --> 00:39:52,350
+بعد C حطلي D وبعدين A بيه A وهنا بيه واللي بعده
+
+382
+00:39:52,350 --> 00:39:55,730
+فرق كله كيف؟
+
+383
+00:39:57,720 --> 00:40:05,680
+في إيه؟ آه الأخير إيه؟ هنا إيه؟ تمام والباقي كله
+
+384
+00:40:05,680 --> 00:40:09,840
+تمام يبقى هاي الجدول اللي عندك وقال يعبي هالفرار
+
+385
+00:40:09,840 --> 00:40:15,840
+هذا من خلال هالاشكال اللي عندك تمام؟ مشان نميز من
+
+386
+00:40:15,840 --> 00:40:20,570
+بين الاتنين أنا حاب الفرار بلون تاني الآن هذا ال
+
+387
+00:40:20,570 --> 00:40:24,170
+identity لو ضربت في أي element بدي يطلع نفس ال
+
+388
+00:40:24,170 --> 00:40:31,810
+element يبقى هنا a,b,c,d بنفس الطريقة هنا a,b,c,d
+
+389
+00:40:31,810 --> 00:40:36,650
+يبقى ضايق لأن بعض الفرقات هنا اتنين تلاتة أربعة
+
+390
+00:40:36,650 --> 00:40:41,650
+وصف الأخير إذا عبيت واحد اتنين تلاتة أربعة وصف
+
+391
+00:40:41,650 --> 00:40:46,770
+الأخير تحصيل حصل العنصر اللي غايب هو العنصر تمام
+
+392
+00:40:46,770 --> 00:40:59,300
+كيف؟ صفة تالت هذا يعني؟ بدي واحد يحكي بس أيوة أيوة
+
+393
+00:40:59,300 --> 00:41:05,540
+هان ماله؟ بدي إيه؟ أحط بيه؟ إيه؟ بيه؟ مقبض هنا
+
+394
+00:41:05,540 --> 00:41:13,160
+إيه؟ هاي عبناله يعني صار العمود هذا جاهز ثاني شوية
+
+395
+00:41:13,160 --> 00:41:19,760
+عندك إين دي؟ دي دول هنا جداش؟ C العمود التالت عمود
+
+396
+00:41:19,760 --> 00:41:25,820
+التالت هذا إيه؟ إيه تمام ميري مية المية بقى برضه
+
+397
+00:41:25,820 --> 00:41:34,040
+المشكلة قاعدة هذا هذا لا إيه موجودة هذا إيه تمام
+
+398
+00:41:34,040 --> 00:41:39,380
+ضايل إيش عندنا ضايل هنا في عنصرين وهنا في عنصرين
+
+399
+00:41:39,380 --> 00:41:45,360
+هنا في اتنين وهنا في اتنين مشكلة مش
+
+400
+00:41:45,360 --> 00:41:46,060
+هتكره بس
+
+401
+00:41:50,390 --> 00:41:57,910
+طيب إذا حلنا واحد بتبقى انحلت قضيتنا، كيف؟ ده قطر
+
+402
+00:41:57,910 --> 00:42:02,510
+مافيش حد، ده قطر، ضرب، وفق برأسي، مالك أنت؟ في حد
+
+403
+00:42:02,510 --> 00:42:11,750
+عنده اقتراح؟ أيوة في
+
+404
+00:42:11,750 --> 00:42:16,550
+عندي هي اتنين وهنا اتنين وجيت أخوك بهنا اتنين و
+
+405
+00:42:16,550 --> 00:42:21,350
+هنا اتنين هنا؟
+
+406
+00:42:21,350 --> 00:42:27,470
+إيش هحط؟ دي طب
+
+407
+00:42:27,470 --> 00:42:31,100
+كيف هتحطها؟ كيف؟ أستاذ أستاذ أستاذ أستاذ أستاذ
+
+408
+00:42:31,100 --> 00:42:34,280
+استاذ أستاذ أستاذ أستاذ أستاذ أستاذ أستاذ أستاذ
+
+409
+00:42:34,280 --> 00:42:37,120
+استاذ أستاذ أستاذ أستاذ أستاذ استذ استذ استذ استذ
+
+410
+00:42:37,120 --> 00:42:41,440
+استذ استذ استذ استذ استذ استذ استذ استذ استذ استذ
+
+411
+00:42:41,440 --> 00:42:41,720
+استذ استذ استذ استذ استذ استذ استذ استذ استذ استذ
+
+412
+00:42:41,720 --> 00:42:42,660
+استذ استذ استذ استذ استذ استذ استذ استذ استذ استذ
+
+413
+00:42:42,660 --> 00:42:43,140
+استذ استذ استذ استذ استذ استذ استذ استذ استذ استذ
+
+414
+00:42:43,140 --> 00:42:58,540
+استذ استذ استذ استذ استذ استذ استذ استذ استذ است
+
+415
+00:42:58,920 --> 00:43:08,560
+ب في إيه؟ ليش هي إبدالية؟ ما قلتليش إبدالية؟ رأس
+
+416
+00:43:08,560 --> 00:43:13,080
+نقطة، رأس رمز،
+
+417
+00:43:13,080 --> 00:43:16,280
+رأس في العمون فيه ب، في الآخر مافيش ب
+
+418
+00:43:21,670 --> 00:43:32,290
+هنا؟ في هنا في element هنا في واحد هنا يا
+
+419
+00:43:32,290 --> 00:43:38,970
+الله مافيه اتنين فيه رمزين هنا برضه طب شوف شغلها
+
+420
+00:43:38,970 --> 00:43:44,170
+العفرة شوف شغلها العفرة يا رياضيل إيه وقول و ارينا
+
+421
+00:43:44,170 --> 00:43:44,470
+شوف
+
+422
+00:43:48,580 --> 00:43:51,900
+لازم يطلع فيه C لأنه لازم يكون في السطر اللي هي C
+
+423
+00:43:51,900 --> 00:43:57,120
+إيه إنه C قصدك؟ لأ غاد هذا C؟ لازم يطلع فيه C طيب
+
+424
+00:43:57,120 --> 00:44:00,380
+فمش ممكن يطلع فيه .. ليش يطلع فيه C؟ منفعش يطلع
+
+425
+00:44:00,380 --> 00:44:05,120
+لهذه سطر، نفهم منه، نفهم منها، منفعش يطلع في
+
+426
+00:44:05,120 --> 00:44:08,680
+الجنبه لإنه فيه في جهة C عشان يكون وفقه ومنفعش
+
+427
+00:44:08,680 --> 00:44:11,180
+يطلع في اللي تحت عشان فيه غاد C فبقى الشركة اللي
+
+428
+00:44:11,180 --> 00:44:17,540
+مدتش تغير رياضيمظبوط يا حزيزي إيش رأيك لو جيه تقول
+
+429
+00:44:17,540 --> 00:44:27,800
+لك a في a قد ايش بده يساوي a في a ب b تمام طيب و b
+
+430
+00:44:27,800 --> 00:44:39,760
+في b b في b ب d طب لو قوللك c في c c في c ب a
+
+431
+00:44:39,760 --> 00:44:41,960
+مظبوط
+
+432
+00:44:43,310 --> 00:44:50,990
+طيب إيش رأيك لو جيت أخد إيه في بي إيه في بي يعني
+
+433
+00:44:50,990 --> 00:44:55,750
+اللي يعني مديها ده عارفة كدهش طيب بلغتنا هنا إيه
+
+434
+00:44:55,750 --> 00:45:04,110
+في بي بدي ساوي c في c في a في a مظبوط؟
+
+435
+00:45:04,420 --> 00:45:11,220
+هذا A في B يبقى C C A A تمام هذا الكلام بده يساوي
+
+436
+00:45:11,220 --> 00:45:23,300
+C C في A يبقى C في A إيش بتطلع D يبقى C D A تمام
+
+437
+00:45:23,300 --> 00:45:31,740
+طب لو جيت الآن D في A إيش بيطلع عندي E يبقى C E
+
+438
+00:45:31,740 --> 00:45:38,890
+يبقى ب C ماشي يبقى الحين صارت هذه C وبالتالي هذه
+
+439
+00:45:38,890 --> 00:45:46,170
+إيش صارت D وبالتالي انحلت كل المشاكل صار C D E A
+
+440
+00:45:46,170 --> 00:45:54,170
+يبقى هنا B و B C D A يبقى هنا A شغل رياضي سليم ولا
+
+441
+00:45:54,170 --> 00:45:58,150
+واحد بيقدر يقولك فيه أي شغل أي شغل رياضي مظبوط من
+
+442
+00:45:58,150 --> 00:46:02,770
+خلال الجدول يبقى أنت بدك تروح تعبي اللي عندك من
+
+443
+00:46:02,770 --> 00:46:09,110
+خلال المياه من خلال الجدول طيب السؤال اللي بعد هو
+
+444
+00:46:09,110 --> 00:46:15,590
+سؤال ستة وعشرين سؤال ستة وعشرين بيقول ما يأتي
+
+445
+00:46:15,590 --> 00:46:24,990
+prove that إذا كان if ال a b لكل تربيع يساوي a
+
+446
+00:46:24,990 --> 00:46:32,840
+تربيع b تربيع then الـ A في B بده يساوي مين؟ بده
+
+447
+00:46:32,840 --> 00:46:38,900
+يساوي الـ B في A طبعا بدي أثبت أن الـ A في B بده
+
+448
+00:46:38,900 --> 00:46:44,060
+يساوي الـ B في A القصة
+
+449
+00:46:44,060 --> 00:46:49,160
+بسيطة جدا، ما قاليش جي أبيليان، لو قالي جي
+
+450
+00:46:49,160 --> 00:46:52,160
+أبيليان كان قضيتي محلولة، ما قالي جي أبيليان، لكن
+
+451
+00:46:52,160 --> 00:46:59,080
+أنا عندي consider خُدلي A بي لكل تربيع اللي هو بدأ
+
+452
+00:46:59,080 --> 00:47:07,550
+فيها ما ده مش ab يعني يبقى a في b في a في b صح ولا
+
+453
+00:47:07,550 --> 00:47:15,190
+لا طيب هذه تساوي من المعطيات a تربيع b تربيع شوف
+
+454
+00:47:15,190 --> 00:47:20,490
+القانون الشطب الأي ملي بي وقانون الشطب الأي صارلي
+
+455
+00:47:20,490 --> 00:47:26,490
+a يبقى هذا إيش بدي أعطيلك يعني ا بمعنى آخر لو ضربت
+
+456
+00:47:26,490 --> 00:47:30,970
+هذه المعادلة من جهة الشمال في a inverse وضربت من
+
+457
+00:47:30,970 --> 00:47:36,090
+جهة اليمين في b inverse أو ال left cancellation
+
+458
+00:47:36,090 --> 00:47:39,970
+law و ال right cancellation law يبقى هذا الخط
+
+459
+00:47:39,970 --> 00:47:46,630
+عضطيني بي اي بيزي ساوة من a في b لما اضرب هنا في a
+
+460
+00:47:46,630 --> 00:47:51,010
+inverse بطير هذه وبطير واحد من التربية فهيظل هنا
+
+461
+00:47:51,010 --> 00:47:58,550
+عندي قداش a بتظهر بي انفرست بيظهر بي انفرست بيظهر
+
+462
+00:47:58,550 --> 00:48:04,190
+بي انفرست
+
+463
+00:48:04,190 --> 00:48:06,730
+بيظهر بيظهر بيظهر بيظهر بيظهر بيظهر بيظهر بيظهر
+
+464
+00:48:06,730 --> 00:48:07,870
+بيظهر بيظهر بيظهر بيظهر بيظهر بيظهر بيظهر بيظهر
+
+465
+00:48:07,870 --> 00:48:13,810
+بيظهر بيظهر بيظهر بيظهر بيظهر بيظهر
+
+466
+00:48:13,810 --> 00:48:20,110
+ب
+
+467
+00:48:22,250 --> 00:48:29,750
+تلاتة وتلاتين إذا كان ال a xb تلاتة وتنقل a xb
+
+468
+00:48:29,750 --> 00:48:37,570
+يسوى ال c xd يسوى ال c xd هذا يتطلب أن ال a b بده
+
+469
+00:48:37,570 --> 00:48:43,610
+يسوى ال c d عند الخاصية هذه بقول تحت ال proof that
+
+470
+00:48:43,610 --> 00:48:49,530
+ال g is abelian اثبت أن ال g هذه is abelian
+
+471
+00:48:54,000 --> 00:49:01,600
+شو بييللي إنه جى قابيليا بيتلي
+
+472
+00:49:01,600 --> 00:49:08,400
+إنه جى قابيليا بقوله ال proof الآن
+
+473
+00:49:08,400 --> 00:49:18,000
+أنا لو جيت علمين مثلامعطبة معنا العلاقة لأنها AXB
+
+474
+00:49:18,000 --> 00:49:23,700
+بيبقى CXD بيقول لو حصل هذا الكلام عندك إذا
+
+475
+00:49:23,700 --> 00:49:28,920
+automatic كأنه بدي أشطب X من هنا وأشطب X هنا من
+
+476
+00:49:28,920 --> 00:49:33,380
+المصر طبعا رياضيا لأ بس أنا بقول كأنه رياضيا لأ
+
+477
+00:49:33,730 --> 00:49:38,110
+يبقى هنا كإنه a بيبدوا يساوي main CD يعني إذا
+
+478
+00:49:38,110 --> 00:49:45,750
+أعطيت هذه ف a بيبدوا يساوي ال CD الآن أنا بدي
+
+479
+00:49:45,750 --> 00:49:49,650
+أحاول أثبت أنه g a b لإن يعني بدي أثبت أن ال a في
+
+480
+00:49:49,650 --> 00:49:54,410
+b بيبدوا يساوي b في a لكل ال a و ال b اللي موجودة
+
+481
+00:49:54,410 --> 00:50:00,250
+وين في g طب الآن لو جيت العنصر b مش هو b ولا لأ
+
+482
+00:50:03,250 --> 00:50:12,990
+صح؟ طب إيش رأيك لو جيت قلتلك ال a a inverse b هل
+
+483
+00:50:12,990 --> 00:50:21,130
+يساوي ال b في ال a inverse a ولا لا؟ لأن هذا ال
+
+484
+00:50:21,130 --> 00:50:27,110
+identity وهذا ال identity، مظبوط؟ طب اتطلع العنصر
+
+485
+00:50:27,110 --> 00:50:33,110
+اللي في النص هنا والعنصر اللي في النص ده هو نفسه
+
+486
+00:50:33,110 --> 00:50:37,950
+وحاصل ضرب تلت عناصر زي ما أنت شايف بيساووا بعض
+
+487
+00:50:37,950 --> 00:50:43,210
+يبقى بال assumption إيش بدي يطلع a في b بدي يساوي
+
+488
+00:50:43,210 --> 00:50:51,610
+b في a يبقى g is abelian يبقى هنا from assumption
+
+489
+00:50:51,610 --> 00:50:54,790
+we
+
+490
+00:50:54,790 --> 00:51:02,250
+have إن ال A بيبدي سوى ال B إيه هذا بدي أعطينا إن
+
+491
+00:51:02,250 --> 00:51:09,530
+ال G is abelian يعني أنا تحت هذه الخاصية قدرت أحكم
+
+492
+00:51:09,530 --> 00:51:13,910
+على G is abelian لو الخاصية هذه مش عندي لأ يمكن
+
+493
+00:51:13,910 --> 00:51:20,510
+أقدر أثبت أو أبين إن ال G هذه عبارة عن abelian
+
+494
+00:51:20,510 --> 00:51:21,330
+group
diff --git a/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/KpzIv297Rbw_raw.srt b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/KpzIv297Rbw_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7c005b9a15c702e5314ec43b764cb9938f8c4bbf
--- /dev/null
+++ b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/KpzIv297Rbw_raw.srt
@@ -0,0 +1,1664 @@
+1
+00:00:21,400 --> 00:00:24,020
+بسم الله الرحمن الرحيم ان شاء الله شباب اليوم
+
+2
+00:00:24,020 --> 00:00:28,240
+هنفوت في الوحدة الرابعة اللي عنوانها cyclic groups
+
+3
+00:00:28,240 --> 00:00:31,580
+خلينا بس نراجع شوية معروفاتنا في اللي درسناها
+
+4
+00:00:31,580 --> 00:00:35,300
+سابقا في الوحدة التالتة و الوحدة التانية و وحدة
+
+5
+00:00:35,300 --> 00:00:42,900
+المقدمة يمكن لو طلعت على ال ..النص التاريخي هنا أو
+
+6
+00:00:42,900 --> 00:00:45,760
+المقولة اللى موجودة لواحد اسمه Alex مش عارف اشهرها
+
+7
+00:00:45,760 --> 00:00:50,540
+في العام 1991 بتكلم عن لفظة ال group نفسها اللى
+
+8
+00:00:50,540 --> 00:00:54,080
+صارت أهم من لفظة physics وchemistry وحتى
+
+9
+00:00:54,080 --> 00:00:57,900
+mathematics itself الفكرة هنا يا شباب بالنسبة لل
+
+10
+00:00:57,900 --> 00:01:02,820
+chapter الرابع or the cyclic groups هي كالتالي في
+
+11
+00:01:02,820 --> 00:01:06,680
+.. عند أهل الرياضيات في عندهم هوث بحاجة اسمة
+
+12
+00:01:06,680 --> 00:01:08,540
+classification أو التصنيف
+
+13
+00:01:11,260 --> 00:01:15,680
+يعني لما بنيجي بنعرف هيكل جبري أو هيكل تحليلي
+
+14
+00:01:15,680 --> 00:01:20,040
+مجموعة عليها بعض الخصائص والشروط بنحاول نصنف
+
+15
+00:01:20,040 --> 00:01:25,960
+الأنواع هذه المجموعات يعني مثلا في شغلنا مفهوم
+
+16
+00:01:25,960 --> 00:01:35,620
+لجروب هي مجموعة زاد عملية زاد
+
+17
+00:01:35,620 --> 00:01:37,860
+أربع شروط
+
+18
+00:01:40,810 --> 00:01:47,590
+هنلاحظ فيه عدد كبير من الحاجات اللي زي هيك أو
+
+19
+00:01:47,590 --> 00:01:51,310
+المجموعات اللي معرفة عليها عملية و بتحقق الأربع
+
+20
+00:01:51,310 --> 00:01:55,910
+شروط و اللي بنسميها group لكن هل هذه كلها زي بعض؟
+
+21
+00:01:55,910 --> 00:02:04,430
+هل هي نفس الشيء؟ هل هي صور مختلفة لنفس المفهوم؟
+
+22
+00:02:04,430 --> 00:02:09,040
+بيجي هنا السؤاللما بدأت أتعامل مع ال groups لجأت
+
+23
+00:02:09,040 --> 00:02:14,740
+أنه عندي فرصة أني أصنع groups بأي order بديها ممكن
+
+24
+00:02:14,740 --> 00:02:21,120
+أبدأ ب order 1,2,3,4,N او بنتكلم عن ZN ممكن أتكلم
+
+25
+00:02:21,120 --> 00:02:27,160
+عن ال groups ال order إلى infinity طيب هى نوع من
+
+26
+00:02:27,160 --> 00:02:32,370
+أنواع التصنيف أني أصنف ال group حسب عدد أنصرهافي
+
+27
+00:02:32,370 --> 00:02:38,010
+نوع تاني اني هصنف ال group حسب العملية نفسها بتحقق
+
+28
+00:02:38,010 --> 00:02:44,430
+شرط إضافي ولا لأ زي مين ال abelian و ال non
+
+29
+00:02:44,430 --> 00:02:52,430
+abelian و كان عندي قسم ل groups لصنفين صنف abelian
+
+30
+00:02:52,430 --> 00:02:58,030
+و صنف non abelian ال abelian نفسه بدنا نصنف فيه
+
+31
+00:02:58,030 --> 00:03:05,360
+أيضايعني في ال abelian أنا بإمكاني ألاقي نوعين نوع
+
+32
+00:03:05,360 --> 00:03:14,640
+زي ال R مع الجامع و نوع زي ال Z برضه مع الجامع
+
+33
+00:03:14,640 --> 00:03:20,860
+لاحظوا نفس العملية و هذه أصلا جزء من ..يعني ال Z
+
+34
+00:03:20,860 --> 00:03:27,790
+جزء من مين؟ من ال Rلكن الـ Z مع الجامعة بتحقق
+
+35
+00:03:27,790 --> 00:03:35,050
+خاصية انه جميع العناصر بقدر اكتبهم تركيبة معينة من
+
+36
+00:03:35,050 --> 00:03:40,330
+عنصر ما يعني كل العناصر في الـ Z عبارة عن power
+
+37
+00:03:40,330 --> 00:03:45,550
+لمين؟ للواحد طبعا ال N عبارة عن واحد plus N ليه؟ N
+
+38
+00:03:45,550 --> 00:03:51,670
+في واحد لأن عملية الضرب هنا تتحول ليش؟ لجامعة في
+
+39
+00:03:51,670 --> 00:03:56,050
+القارة ده كلام مش ممكن اعملهما عنده تنتين abelian
+
+40
+00:03:56,050 --> 00:04:02,450
+فأنا لازم أصنف ال groups اللي بتحقق هذا الكلام تحت
+
+41
+00:04:02,450 --> 00:04:06,830
+إطار معين و ال groups اللي بتحققش هذا الكلام تحت
+
+42
+00:04:06,830 --> 00:04:12,630
+إطار آخر الإطار تبع ال group z ومثلاتها هنسميه ال
+
+43
+00:04:12,630 --> 00:04:20,330
+cyclic groups وهذا هيكون abelian لكن إيش ماله؟ مش
+
+44
+00:04:20,330 --> 00:04:26,350
+cyclicناخد من الـ Z الخاصية الأهم اللي خلتها
+
+45
+00:04:26,350 --> 00:04:31,550
+مختلفة عن ال R و هي ان كل العناصر تركيبة خطية من
+
+46
+00:04:31,550 --> 00:04:36,230
+الواحد و نقول ان ال group علشان تكون cyclic لازم
+
+47
+00:04:36,230 --> 00:04:40,990
+تكون كل العناصر تركيبة خطية من عنصر معاه يعني
+
+48
+00:04:40,990 --> 00:04:44,270
+بنسمي هذا العنصر اللي العناصر تركيبة .. او مش
+
+49
+00:04:44,270 --> 00:04:48,490
+تركيبة خطية منه power لهذا العنصر هذا العنصر هسميه
+
+50
+00:04:48,490 --> 00:04:55,820
+مولد او generator لل groupنجي للأهمية، ليش احنا
+
+51
+00:04:55,820 --> 00:05:04,560
+بندرس التصنيف؟ سببين، السبب الأول، هذا بهمني لما
+
+52
+00:05:04,560 --> 00:05:08,740
+أدرس لاحقا عملية ال isomorphism و ال homomorphism،
+
+53
+00:05:08,740 --> 00:05:14,260
+و بهمني لمعرفة أنههدول ال groups زي بعض فبحطهم مع
+
+54
+00:05:14,260 --> 00:05:19,080
+بعض وبصير أتعامل مع راس إلهم وما ينطبق عليه ينطبق
+
+55
+00:05:19,080 --> 00:05:23,960
+على الباقى الشغلة التانية بسهل علي التعامل مع
+
+56
+00:05:23,960 --> 00:05:28,310
+التركيبة الداخلية لل groupsكيف يعني؟ يعني انا لو
+
+57
+00:05:28,310 --> 00:05:32,890
+بشر على group Cyclic الجروب الـ Cyclic بتحقق خصائص
+
+58
+00:05:32,890 --> 00:05:37,290
+بتخليني هذه الخصائص بسهولة اقدر اتعامل مع ال
+
+59
+00:05:37,290 --> 00:05:43,430
+orders تبعت العناصر اتعامل مع خصائص العنصر نفسه
+
+60
+00:05:43,430 --> 00:05:48,070
+لحل المعادلات المتعلقة بالعناصر الموجودة ضمن هذه
+
+61
+00:05:48,070 --> 00:05:49,550
+ال groups
+
+62
+00:05:52,750 --> 00:05:58,030
+في حين مثلا اللي أبيه لأنه مش cyclic مقدرش أنفذ
+
+63
+00:05:58,030 --> 00:06:04,370
+هذا الكلام إلا لما بدي أخد نظريات أكثر تقدما في ال
+
+64
+00:06:04,370 --> 00:06:10,130
+chapter الرابع اليوم ابنهي كل ما يتعلق بال cyclic
+
+65
+00:06:10,130 --> 00:06:15,410
+groups من ناحية التركيب الداخلي في chapter عشرة أو
+
+66
+00:06:15,410 --> 00:06:20,530
+chapter 11 تحديدابنتناول ما يتعلق بالـ Ability
+
+67
+00:06:20,530 --> 00:06:26,250
+Group الـ finite من ناحية التركيب الداخلي بظل
+
+68
+00:06:26,250 --> 00:06:32,150
+الصعوبة في التعامل مع مين؟ مع شغلتين الـ Ability
+
+69
+00:06:32,150 --> 00:06:36,960
+Infiniteوالـ non-abelian طبعا الناس اللي بيشتغلوا
+
+70
+00:06:36,960 --> 00:06:39,680
+في الجابر الحديث اللي هم نظرياتهم و اللي هم شغلهم
+
+71
+00:06:39,680 --> 00:06:42,980
+في هذا الموضوع اللي احنا مش هنتطرق له في هذا
+
+72
+00:06:42,980 --> 00:06:47,180
+المساق إذا ضال وجد احنا هناخد شبطة راح دعش ما
+
+73
+00:06:47,180 --> 00:06:49,480
+يتعلق بالـ finite abelian group لكن على الأقل
+
+74
+00:06:49,480 --> 00:06:54,700
+هننهي من الـcyclic groups بالنسبة للتعريف التعريف
+
+75
+00:06:54,700 --> 00:06:59,560
+مر علينا سابقا خلال الوحدة السابقة اتكلمنا عن ايش
+
+76
+00:06:59,560 --> 00:07:10,510
+بتعني كلمة cyclicEgo أي سؤال يا شباب؟ في أي سؤال؟
+
+77
+00:07:10,510 --> 00:07:20,830
+طيب نلخص بعض الأمور كمثال
+
+78
+00:07:20,830 --> 00:07:31,830
+واحد لو أخدنا Z with addition
+
+79
+00:07:34,660 --> 00:07:47,520
+أخدنا z مع عملية الجمعة we can show that for any x
+
+80
+00:07:47,520 --> 00:07:57,220
+أو n ينتمي ل z that ال n بتتساوي واحد أس أن أو
+
+81
+00:07:57,220 --> 00:08:04,250
+عبارة عن ال n في واحدأيضا الان بتتساوي سالب واحد
+
+82
+00:08:04,250 --> 00:08:10,570
+او سالب ان اللي عبارة عن سالب ان بسالب واحد يعني
+
+83
+00:08:10,570 --> 00:08:22,610
+each element in z is a power of
+
+84
+00:08:22,610 --> 00:08:33,480
+واحد and a power of سالب واحدهذا بيخلينا نقول ان
+
+85
+00:08:33,480 --> 00:08:43,260
+واحد and سالب واحد are generators of
+
+86
+00:08:43,260 --> 00:08:48,120
+the group Z
+
+87
+00:08:48,120 --> 00:08:58,580
+عبارة عن مولدات لأناصر ال group Z and Z is a
+
+88
+00:08:58,580 --> 00:08:59,200
+cyclic
+
+89
+00:09:06,930 --> 00:09:13,870
+الجروب مثال اخر برضه على z لكن على مين على zn لو
+
+90
+00:09:13,870 --> 00:09:19,770
+جيت انا قولت zn اللي عبارة عن zero واحد اتنين
+
+91
+00:09:19,770 --> 00:09:27,070
+تلاتة land in minus one we
+
+92
+00:09:27,070 --> 00:09:30,750
+can show also
+
+93
+00:09:32,960 --> 00:09:48,720
+that any element in ZN is a power of واحد هل
+
+94
+00:09:48,720 --> 00:09:54,200
+الواحد و بس لأ بقدر ألاقي عراسي أخرى هنطلق لها
+
+95
+00:09:54,200 --> 00:09:57,780
+لاحقا هكون الواحد is a generator
+
+96
+00:10:00,210 --> 00:10:10,030
+of Zn and Zn is cyclic طبعا Zn لما بتناولها من دون
+
+97
+00:10:10,030 --> 00:10:14,190
+ما احط عليها شروط اضافية فانا بتكلم عن Zn مع عملية
+
+98
+00:10:14,190 --> 00:10:25,850
+عملية الجامعة modulo N طيب لو أخدنا مثلا
+
+99
+00:10:31,850 --> 00:10:43,490
+U عشرة الـ U عشرة مين فيها؟ واحد، تلاتة، سبعة،
+
+100
+00:10:43,490 --> 00:10:49,370
+تسعة طبعا أنا مقدرش أقول generated by واحد، لأن
+
+101
+00:10:49,370 --> 00:10:54,040
+الواحد عبارة عن إيشعلى ال identity لكن انا مقدر
+
+102
+00:10:54,040 --> 00:10:58,880
+اقول ان تلاتة اص واحد بتساوي تلاتة تلاتة اص اتنين
+
+103
+00:10:58,880 --> 00:11:05,600
+تلاتة فتلاتة جديش تسعة تلاتة اص تلاتة عبارة عن
+
+104
+00:11:05,600 --> 00:11:10,940
+سبعة و عشرين بضار جديش سبعة تلاتة اص اربعة واحد
+
+105
+00:11:10,940 --> 00:11:19,120
+معناته U عشرة بتساوي generated by تلاتة ايضا هي
+
+106
+00:11:19,120 --> 00:11:28,660
+generated by مينU10 Generated by 7 وبالتالي U10 is
+
+107
+00:11:28,660 --> 00:11:31,780
+Cyclic
+
+108
+00:11:31,780 --> 00:11:40,220
+U10
+
+109
+00:11:40,220 --> 00:11:43,260
+Cyclic لكن هل كل ال UN Cyclic
+
+110
+00:11:48,530 --> 00:11:56,790
+U10 Cyclic هل كل ال U N Cyclic؟ أربع أعطيني مثال
+
+111
+00:11:56,790 --> 00:12:05,390
+على U U8 N مش Cyclic نجرب ال U8 مين فيها ال U8؟
+
+112
+00:12:05,390 --> 00:12:09,590
+طيب
+
+113
+00:12:09,590 --> 00:12:15,550
+هلاحظ أنه تلاتة أسواحد تلاتة تلاتة تربية عبارة عن
+
+114
+00:12:15,550 --> 00:12:20,510
+واحدخمسة أُس واحد خمسة لكن خمسة تربيع عبارة عن
+
+115
+00:12:20,510 --> 00:12:27,450
+واحد سبعة أُس واحد سبعة لكن سبعة تربيع برضه واحد
+
+116
+00:12:27,450 --> 00:12:33,550
+وبالتالي U تمانية ليست generated by تلاتة وليست
+
+117
+00:12:33,550 --> 00:12:40,410
+generated by خمسة وليست generated by سبعة هذا
+
+118
+00:12:40,410 --> 00:12:43,830
+معناته U تمانية is not
+
+119
+00:12:46,600 --> 00:12:55,140
+Cyclic ليست جروب و لجروب هذه Cyclic الأربع أمثلة
+
+120
+00:12:55,140 --> 00:13:02,940
+اللي كتبناها بتوضح ليه ان زد Cyclic زد N دايما
+
+121
+00:13:02,940 --> 00:13:07,620
+Cyclic لأي N المثال التالت و الرابع بيقول ال UN قد
+
+122
+00:13:07,620 --> 00:13:14,140
+تكون Cyclic و قد لا تكون Cyclic واضح
+
+123
+00:13:17,290 --> 00:13:24,110
+واضح شباب؟ طبعا
+
+124
+00:13:24,110 --> 00:13:39,630
+هي الأمثلة الموجودة قدامك هنبدأ
+
+125
+00:13:39,630 --> 00:13:45,050
+بعد هذا المثال في أولى نظريات الوحدة الرابعة
+
+126
+00:13:45,050 --> 00:13:45,910
+theorem
+
+127
+00:13:49,560 --> 00:13:50,400
+أربعة واحدة
+
+128
+00:14:08,250 --> 00:14:12,370
+عشان انا اقدر اتناول في نظرية لاحقة بعد نظرية 4-1
+
+129
+00:14:12,370 --> 00:14:16,850
+اسمها ال fundamental theorem of cyclic groups
+
+130
+00:14:16,850 --> 00:14:22,870
+النظرية الأساسية للزمر الدورة لازم انا اتناول
+
+131
+00:14:22,870 --> 00:14:31,180
+مسألة وقتاش two powers لأنصر ما بيتساوىوقتاش بقول
+
+132
+00:14:31,180 --> 00:14:37,660
+ان AI بتساوي AJ فأي group لو أخدت أي عنصر هذا
+
+133
+00:14:37,660 --> 00:14:44,860
+قدامه خيارين يا إله infinite order يا إله finite
+
+134
+00:14:44,860 --> 00:14:50,720
+order بدنا نتناول في حالة ال infinite order وقتاش
+
+135
+00:14:52,330 --> 00:14:56,690
+الـ AI بيتساوى AJ مين هو الـ I والـ J اللي بيخلي
+
+136
+00:14:56,690 --> 00:15:01,050
+هذا الكلام صحيح وفي حالة الـ finite الـ AI والـ AJ
+
+137
+00:15:01,050 --> 00:15:06,670
+واكتش بيتساوى وإيش علاقة الـ I والـ J في هذه
+
+138
+00:15:06,670 --> 00:15:15,550
+الحالة كنص النظرية خلينا نكتبه let J be
+
+139
+00:15:15,550 --> 00:15:18,730
+a group
+
+140
+00:15:22,250 --> 00:15:32,050
+A ينتمي للـ J الحالة الأولى if order ال A بساوي
+
+141
+00:15:32,050 --> 00:15:40,370
+infinite يعني ال A has infinite order then AI
+
+142
+00:15:40,370 --> 00:15:50,930
+بتساوي AJ if and only if ال I بساوي G and
+
+143
+00:15:55,120 --> 00:16:02,260
+generated by a بتبدأ بال identity a هي تربية هي
+
+144
+00:16:02,260 --> 00:16:09,300
+تكيب ولا تنتهي اما
+
+145
+00:16:09,300 --> 00:16:15,080
+في حالة ما يكون ال order finite الوضع شوية بيتغير
+
+146
+00:16:15,080 --> 00:16:21,480
+تنين
+
+147
+00:16:21,480 --> 00:16:32,290
+if order ال aبساوي and then ai
+
+148
+00:16:32,290 --> 00:16:41,850
+بساوي aj if and only if ال n تقسم ال i minus g مش
+
+149
+00:16:41,850 --> 00:16:49,910
+بس هيك and generated by a ده تساوي ال identity a
+
+150
+00:16:49,910 --> 00:17:00,830
+a2and a and minus one في كل
+
+151
+00:17:00,830 --> 00:17:08,370
+حالة بالنسبة ل a أُس i بيساوي a أُس j في نتائج
+
+152
+00:17:08,370 --> 00:17:19,970
+وكتش بيتساوى الجزء الأول assume that أن أردر ال a
+
+153
+00:17:19,970 --> 00:17:28,160
+بدأ تساوي infiniteهذا معناته ان AOSN لا يساوي ال
+
+154
+00:17:28,160 --> 00:17:38,480
+identity for any N في الـ Z في
+
+155
+00:17:38,480 --> 00:17:46,250
+اتجاه سحل if I بساوي JA to I بيبقى تساوي A to G جي
+
+156
+00:17:46,250 --> 00:17:50,090
+العكسي انه I بيساوي جي بيقضيلي انه A أُس I بيساوي
+
+157
+00:17:50,090 --> 00:17:54,910
+A أُس G وهذا أمر منطقي نجي لاتجاه التاني Assume
+
+158
+00:17:54,910 --> 00:18:06,190
+that A I بيبقى تساوي ن لا يساوي بلاش في زيد بيحطها
+
+159
+00:18:06,190 --> 00:18:09,190
+في ال natural number اتكلم عن ال order يكون
+
+160
+00:18:09,190 --> 00:18:17,180
+positiveassume that a أُس i بدت ساوي a أُس j هذا
+
+161
+00:18:17,180 --> 00:18:30,360
+معناته let أو assume that ان جي أو اي لا يساوي جي
+
+162
+00:18:30,360 --> 00:18:34,300
+انا
+
+163
+00:18:34,300 --> 00:18:38,480
+بدي اثبت ان اي بيساوي جي هفتخد ان اي لا يساوي جي
+
+164
+00:18:42,320 --> 00:18:51,960
+without lost of generality بدون فقدان التعميم ذات
+
+165
+00:18:51,960 --> 00:18:59,660
+I أكبر من J ما هو ال I لا يساوي ال J يا ال I أكبر
+
+166
+00:18:59,660 --> 00:19:06,840
+يا ال J أكبر فحنفترض أنه ال I أكبر حاجة ال AI بدت
+
+167
+00:19:06,840 --> 00:19:16,070
+ساوي AJ يعني AIminus j بدت ساو ال identity هداش
+
+168
+00:19:16,070 --> 00:19:22,170
+حيخليني أقول but
+
+169
+00:19:22,170 --> 00:19:32,190
+a أس n لا يساو ال identity لكل n في ال N هداش
+
+170
+00:19:32,190 --> 00:19:37,190
+معناته معناته لازم ال I minus ال J ساو Zero
+
+171
+00:19:37,190 --> 00:19:39,390
+وبالتالي
+
+172
+00:19:42,900 --> 00:19:49,260
+إذا حسيني أندي تناقض هان كيف بقول كيف
+
+173
+00:19:49,260 --> 00:19:53,700
+بقول إن ال I minus ال J بتساوي ال identity وال I
+
+174
+00:19:53,700 --> 00:20:00,460
+minus J ينتمي لل N وال A أس N لا يساوي ال identity
+
+175
+00:20:00,460 --> 00:20:08,140
+لأي N في N هذا contradiction فاني أعملها هان
+
+176
+00:20:08,140 --> 00:20:12,440
+وبالتالي I بدأ تساوي
+
+177
+00:20:17,690 --> 00:20:24,410
+طيب هذا معناته انه generated by a بتتساوي ال
+
+178
+00:20:24,410 --> 00:20:33,450
+identity ايه تربية ايه تكييب and a of i and a of j
+
+179
+00:20:33,450 --> 00:20:38,610
+are distinct خلي
+
+180
+00:20:38,610 --> 00:20:44,810
+اعمله since ال a of i and a of j are distinct from
+
+181
+00:20:44,810 --> 00:20:45,290
+any
+
+182
+00:20:50,630 --> 00:21:00,130
+I يساوي جيه هجات ال powers لل A A أس I و A أس جيه
+
+183
+00:21:00,130 --> 00:21:04,730
+لايتساوى إلا لو تساوى ال I و الجيه لما ال I و
+
+184
+00:21:04,730 --> 00:21:08,170
+الجيه مايتساووش هذه القيم اللي بتطلع معاش بتكون
+
+185
+00:21:08,850 --> 00:21:15,310
+مختلفة مابصلش في لحظة معينة لأنصر موجود قبل هيك كل
+
+186
+00:21:15,310 --> 00:21:19,550
+مرة باعطي power جديد بيعطي ناشر أنصر جديد وبالتالي
+
+187
+00:21:19,550 --> 00:21:25,650
+هذه المجموعة مش هتنتهي وبهيك تكون خلص إثبات الجزء
+
+188
+00:21:25,650 --> 00:21:35,250
+الأول أي
+
+189
+00:21:35,250 --> 00:21:35,950
+سؤال؟
+
+190
+00:21:46,140 --> 00:21:50,120
+عشان ال order بيساوي infinity مدام ال order بيساوي
+
+191
+00:21:50,120 --> 00:21:53,220
+infinity مش هيساوي عدد محدود يعني مافيش power لل a
+
+192
+00:21:53,220 --> 00:21:59,980
+بيعطيك ال identity غير ال zero عشان انالو انا
+
+193
+00:21:59,980 --> 00:22:03,020
+خلّيتها N ينتمي ل Z طب ما هو اصلاً A و Zero
+
+194
+00:22:03,020 --> 00:22:06,620
+بيعطيني ال identity فاخدتها في ال N حد هيقول لي
+
+195
+00:22:06,620 --> 00:22:09,920
+طيب و الأعداد السالبة ما هو اصلاً لو ال A أُس سالب
+
+196
+00:22:09,920 --> 00:22:13,360
+N بساوي ال identity فال A أُس N هيساوي ال identity
+
+197
+00:22:13,360 --> 00:22:18,320
+وبالتالي لما انا اقول N في ال N فانا بلغ الموجب و
+
+198
+00:22:18,320 --> 00:22:28,500
+بلغ السالب و بكتفي بمين بالصفر جزء التاني assume
+
+199
+00:22:30,900 --> 00:22:40,420
+that هو أخضر الـ A بدأت ساوي الـ N يعني A أُس N
+
+200
+00:22:40,420 --> 00:22:46,840
+بدأت ساوي الـ Identity إيش المطلوب يثبته نرجع للنص
+
+201
+00:22:46,840 --> 00:22:49,880
+انه
+
+202
+00:22:49,880 --> 00:22:55,540
+A أُس I بساوي A أُس G if and only if ال N بتقسم ال
+
+203
+00:22:55,540 --> 00:23:05,690
+I minus G في اتجاه سهلإذا I بيساوي الـ J ثم A أس I
+
+204
+00:23:05,690 --> 00:23:10,770
+بيبقى بيساوي الـJ لحظة، أنا هبدأ بنفس البداية،
+
+205
+00:23:10,770 --> 00:23:19,130
+بنفس الطريقة اللي بدأتها جهة تانية Assume that A
+
+206
+00:23:19,130 --> 00:23:21,930
+أس I بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى
+
+207
+00:23:21,930 --> 00:23:23,430
+بيبقى بيبقى بيبقى بيبقى بيبقى بيبقى A أس J
+
+208
+00:23:27,170 --> 00:23:33,150
+هنثبت ان ال I ناقص ال J من مضاعفات ال N أو ال N
+
+209
+00:23:33,150 --> 00:23:43,730
+بتقسم ال A minus J هذا معناته ال A اقص I minus J
+
+210
+00:23:43,730 --> 00:23:46,090
+ايش ده تساوي ال identity
+
+211
+00:23:49,390 --> 00:23:55,070
+طيب حاجة الجيت أشغل على الأن هنمسح الجملة هذه
+
+212
+00:23:55,070 --> 00:24:00,190
+كتبناها و نرجع نكتب جملة بعدها نكتبها ال I minus J
+
+213
+00:24:00,190 --> 00:24:04,070
+مدام
+
+214
+00:24:04,070 --> 00:24:08,730
+أنا ماحطيت الشروط على I و J فهذا قد يكون سالب و قد
+
+215
+00:24:08,730 --> 00:24:14,850
+يكونموجبه قد يكون zero أنا علشان أبعد عن حالتين
+
+216
+00:24:14,850 --> 00:24:19,110
+حالة ال zero و حالة السالب هفترض زي ما فرضت هنا أن
+
+217
+00:24:19,110 --> 00:24:22,470
+ال I أكبر من ال J إفتراض أن ال I أكبر من ال J يعني
+
+218
+00:24:22,470 --> 00:24:28,270
+أن أنا دخلت على أسلوب الإثبات الغير مباشر يعني بال
+
+219
+00:24:28,270 --> 00:24:31,790
+contradiction وبالتالي لازم أفترض أن ال I لا يساوي
+
+220
+00:24:31,790 --> 00:24:38,630
+ال J assume in contrary that
+
+221
+00:24:40,640 --> 00:24:56,260
+إن الـ I لا يساوي جيه C الـ I أكبر من الجيه Now A
+
+222
+00:24:56,260 --> 00:25:02,080
+أُس I بيبقى تساوي A أُس G يعني A أُس I minus جيه
+
+223
+00:25:02,080 --> 00:25:07,660
+إيش بديه يساوي ال identity طبعا تنساش إن ال I
+
+224
+00:25:07,660 --> 00:25:21,810
+minus Gأكبر من الصفر يعني بينتمي لمين ينتمي طيب
+
+225
+00:25:21,810 --> 00:25:26,910
+using اللي
+
+226
+00:25:26,910 --> 00:25:36,090
+هو ال division algorithm سمعني
+
+227
+00:25:36,090 --> 00:25:41,770
+ال division algorithmأنا بقدر أقول إن الـ I minus
+
+228
+00:25:41,770 --> 00:25:45,570
+J بدأ
+
+229
+00:25:45,570 --> 00:25:52,150
+تساوي الـ QN زائد الـ R والـ R أقل من الـ N وأكبر
+
+230
+00:25:52,150 --> 00:26:00,690
+من الصفر صح؟ في غلط أن
+
+231
+00:26:00,690 --> 00:26:03,970
+أنا شيلت اليسار لما أنا بدي أقول إن اليسار مش
+
+232
+00:26:03,970 --> 00:26:05,910
+موجود بدي مبرر
+
+233
+00:26:08,360 --> 00:26:15,240
+بدي و بقى طب و ليش انا بدي اثبتها هنا هل انا محتاج
+
+234
+00:26:15,240 --> 00:26:28,960
+انفيها طيب
+
+235
+00:26:28,960 --> 00:26:34,500
+يبدو اني بديت خطأ ممكن انا اجابه لعدل بعد هيك طيب
+
+236
+00:26:34,500 --> 00:26:46,500
+nowAOSR عبارة عن AOS I minus الـ J نقصة QN بدا
+
+237
+00:26:46,500 --> 00:26:53,580
+تساوي AOS I minus الـ J في AOS سالب QN اللي عبارة
+
+238
+00:26:53,580 --> 00:26:58,920
+عن الـ Identity في AOS N سالب Q Identity في
+
+239
+00:26:58,920 --> 00:27:07,270
+Identity بدا تساوي ايش Identity يعني بAOSRده السوى
+
+240
+00:27:07,270 --> 00:27:12,330
+ال identity طيب
+
+241
+00:27:12,330 --> 00:27:17,350
+تعالوا نشوف وين الأخطاء اللي وجعنا فيها أول حاجة
+
+242
+00:27:17,350 --> 00:27:22,130
+شباب أناش المطلوب يثبته مش
+
+243
+00:27:22,130 --> 00:27:27,270
+المطلوب يثبته أول حاجة المطلوب أثبت أن ال N تقسم
+
+244
+00:27:27,270 --> 00:27:32,470
+ال I minus ال J أناش
+
+245
+00:27:32,470 --> 00:27:32,970
+فرضت
+
+246
+00:27:39,300 --> 00:27:43,240
+ماشيله علاقة؟ ايش اللي علاقة؟ يعني بقى هذا أول خطأ
+
+247
+00:27:43,240 --> 00:27:47,580
+شوية
+
+248
+00:27:47,580 --> 00:27:52,440
+بس و هذا الخطأ جاب ورا أخطاء تانية فرض أن ال I لا
+
+249
+00:27:52,440 --> 00:27:59,880
+يساوي J و قولت أن ال I أكبر من ال J طبعا
+
+250
+00:27:59,880 --> 00:28:05,860
+و هذا مبني على هذا أنا مطلوب أني أثبتإن ال N تقسم
+
+251
+00:28:05,860 --> 00:28:11,460
+ال I minus ال J هل لو ال I أكبر من ال J ال N قد لا
+
+252
+00:28:11,460 --> 00:28:16,280
+تقسم ال I minus J مالوش
+
+253
+00:28:16,280 --> 00:28:22,740
+علاقة إذا فبنرجع نعدل فرضياتنا و نعدل الدزق هذا
+
+254
+00:28:22,740 --> 00:28:25,920
+بناء على الفرض اللي احنا فرضنا إذا فأنا بدي أفترض
+
+255
+00:28:25,920 --> 00:28:34,650
+هنا إيش أن ال N لا تقسم ال I minus Jتقسم او لا
+
+256
+00:28:34,650 --> 00:28:41,970
+تقسم؟ لا تقسم هل هذي اللي هالازمة هالجيت؟ لأ لأ
+
+257
+00:28:41,970 --> 00:28:48,110
+هجيت ال A اقص I minus الجيه بدي ساوي ال E انا لما
+
+258
+00:28:48,110 --> 00:28:52,550
+قولت انه I minus الجيه في ال .. بناء على ايش؟ على
+
+259
+00:28:52,550 --> 00:28:58,130
+انه ال I أكبر من الجيه طيب بصراحة ال I أكبر من
+
+260
+00:28:58,130 --> 00:29:00,210
+الجيه يبقى دي ونحن سيه؟ في ال Z
+
+261
+00:29:04,420 --> 00:29:08,320
+Using Division Algorithm معرفة على مين عزد في هذه
+
+262
+00:29:08,320 --> 00:29:14,580
+الخطوة سليمة هرجت هنرجع هان لما انا قلتلك انه
+
+263
+00:29:14,580 --> 00:29:18,860
+ممنوع نشيل المساواة الا بمبرر صار المبرر موجود ولا
+
+264
+00:29:18,860 --> 00:29:24,480
+لأ الشوة انه الان لو تقسم ال I minus J فانا بروحش
+
+265
+00:29:24,480 --> 00:29:31,810
+بعمل هان بشيل المساواةبكمل a-r بيساوي a-i-j-q-n
+
+266
+00:29:31,810 --> 00:29:40,350
+بصل ان a-r بيساوي ال identity since r أكبر أو
+
+267
+00:29:40,350 --> 00:29:46,950
+يساوي ال zero a-r بيساوي ال identity طبعا ال r ما
+
+268
+00:29:46,950 --> 00:29:51,150
+بين ال n و أكبر من ال zero ال a-r بيساوي ال
+
+269
+00:29:51,150 --> 00:29:53,990
+identity order لل a بيساوي n
+
+270
+00:29:57,830 --> 00:30:01,950
+A contradiction مين
+
+271
+00:30:01,950 --> 00:30:07,110
+هو ال contradiction هادا ال order هو n وصار عندي
+
+272
+00:30:07,110 --> 00:30:13,990
+عدد مش صفري أقل من ال n بيعطينا ال identity so وين
+
+273
+00:30:13,990 --> 00:30:23,600
+الخلل انه لازم ال R يساوي zero and ال n تقسمالـ I
+
+274
+00:30:23,600 --> 00:30:27,340
+minus J و بالتالي الجزئية الأولى من المرحلة
+
+275
+00:30:27,340 --> 00:30:33,000
+التانية تم إثباتها أعيد بسرعة عشان .. أعيد بسرعة
+
+276
+00:30:33,000 --> 00:30:39,040
+لإنه طريقة الإثبات صار فيها تعديل أنا فرضت ..
+
+277
+00:30:39,040 --> 00:30:43,380
+بالعمد يعني أنت عمد فيك و لا عشان تتعلم ولا .. مش
+
+278
+00:30:43,380 --> 00:30:45,880
+دائما بكون عاملة بالعمد أحيانا أنا بخ .. ب .. يعني
+
+279
+00:30:45,880 --> 00:30:52,700
+انا أخلطت في شغلة و برجع بعدلهاطيب فعرضت هنا إن ال
+
+280
+00:30:52,700 --> 00:30:58,460
+A Os I بدأ تساوي A Os Jفانا بشتغل على عكس المطلوب
+
+281
+00:30:58,460 --> 00:31:03,360
+فرضت ان الان لا يقسم ال I minus J وصلت ان I minus
+
+282
+00:31:03,360 --> 00:31:07,620
+J بده يساوي ال identity و I minus J في ال Z و الان
+
+283
+00:31:07,620 --> 00:31:11,560
+عدد طبيعي فانا بقدر اشتغل بال division algorithm و
+
+284
+00:31:11,560 --> 00:31:15,540
+اكتب هذا الكلام و علشان الان لا تقسم I minus J
+
+285
+00:31:15,540 --> 00:31:19,760
+الار لان تساوي Zero وصلت بعد الحسابات لان I minus
+
+286
+00:31:19,760 --> 00:31:23,560
+R بده يساوي ال identity طيب I minus R بده يساوي ال
+
+287
+00:31:23,560 --> 00:31:31,230
+identityوالـ R عدد طبيعي يعني يكون أكبر من ال
+
+288
+00:31:31,230 --> 00:31:36,210
+order لكن هو أصغر من ال order فصار تناقض يعني لازم
+
+289
+00:31:36,210 --> 00:31:43,870
+ال R يساوي 0 و الأن تقسم ال I minus G الجهة
+
+290
+00:31:43,870 --> 00:31:48,630
+التانية بسطر واحد لو ال I بيساوي ال G فال A و I
+
+291
+00:31:48,630 --> 00:31:49,990
+بيساوي A و G
+
+292
+00:31:57,620 --> 00:32:05,680
+خلّيني أكتب الجهة التانية مرة أخرى Assume أن
+
+293
+00:32:05,680 --> 00:32:15,420
+N تقسم I minus J معناته أن I minus J تتساوي Q
+
+294
+00:32:15,420 --> 00:32:26,520
+تعملناها T في N و T من أين؟ من Zهجة A أُس I minus
+
+295
+00:32:26,520 --> 00:32:31,240
+الـ J عبارة عن A أُس T N يعني عبارة عن A أُس N أُس
+
+296
+00:32:31,240 --> 00:32:36,020
+T بدت سوى الـ Identity A أُس I minus الـ J بدت سوى
+
+297
+00:32:36,020 --> 00:32:44,700
+الـ Identity A أُس I بدت سوى A أُس G طيب،
+
+298
+00:32:44,700 --> 00:32:49,260
+فضل هذه؟
+
+299
+00:32:49,260 --> 00:32:55,310
+تركز معايافرضت أن الـ A أُس I بيبقى تساوي A أُس J
+
+300
+00:32:55,310 --> 00:33:02,950
+فرضت
+
+301
+00:33:02,950 --> 00:33:09,290
+الـ B فرضت أن الـ A أُس I بيبقى تساوي A أُس J فرضت
+
+302
+00:33:09,290 --> 00:33:09,690
+أن الـ B فرضت أن الـ A أُس I بيبقى تساوي A أُس J
+
+303
+00:33:09,690 --> 00:33:12,050
+فرضت أن الـ N تقسم الـ I minus J فرضت أن الـ N لا
+
+304
+00:33:12,050 --> 00:33:19,000
+تقسم الـ I minus Jيبقى a-i يبقى a-j يبقى a-j يبقى
+
+305
+00:33:19,000 --> 00:33:20,000
+a-j يبقى a-j يبقى a-j يبقى a-j يبقى a-j يبقى a-j
+
+306
+00:33:20,000 --> 00:33:20,200
+يبقى a-j يبقى a-j يبقى a-j يبقى a-j يبقى a-j يبقى
+
+307
+00:33:20,200 --> 00:33:21,480
+a-j يبقى a-j يبقى a-j يبقى a-j يبقى a-j يبقى a-j
+
+308
+00:33:21,480 --> 00:33:22,100
+يبقى a-j يبقى a-j يبقى a-j يبقى a-j يبقى a-j يبقى
+
+309
+00:33:22,100 --> 00:33:30,580
+a-j يبقى a-j يبقى a-j يبقى a-j يبقى
+
+310
+00:33:30,580 --> 00:33:38,510
+a-j يبقى a-j يبقى a-jالـ A أُس I مينص الـ G
+
+311
+00:33:38,510 --> 00:33:42,570
+Identity A أُس سالب Q N عبارة عن A أُس N أُس سالب
+
+312
+00:33:42,570 --> 00:33:46,630
+Q برضه Identity Identity في Identity بيعطيك ال
+
+313
+00:33:46,630 --> 00:33:50,610
+Identity يكبر A أُس R بيبقى يساوي ال Identity هجيت
+
+314
+00:33:50,610 --> 00:33:54,850
+أي عدد طبيعي برفع ال A له وبيعطيني ال Identity
+
+315
+00:33:54,850 --> 00:33:59,470
+لازم يكون أكبر من مين؟ من ال order لأن ال order هو
+
+316
+00:33:59,470 --> 00:34:03,230
+أصغر عدد طبيعي بيخلي ال A يروح لمين؟
+
+317
+00:34:05,600 --> 00:34:08,900
+هو المفروض يكون أكبر لكن حسب الـ Divisional Root
+
+318
+00:34:08,900 --> 00:34:14,080
+ما هو أصغر فصار عندي تناقض وبالتالي لازم ال R
+
+319
+00:34:14,080 --> 00:34:19,860
+تساوي صفر و ال order أو ال A ال N تقسم ال I minus
+
+320
+00:34:19,860 --> 00:34:30,620
+J تجاه العكس سهل يعني مافيش فيه تأخير كيف؟ ما
+
+321
+00:34:30,620 --> 00:34:34,600
+هو حسب ال Divisional Root مستحيل يساوي ال Nطالما
+
+322
+00:34:34,600 --> 00:34:38,820
+بتجسم الباقي دائما أقل من اللي بتجسم عليه وإلا لو
+
+323
+00:34:38,820 --> 00:34:44,820
+بيساوي اللي بتجسم عليه هيظل باقي بتضالي
+
+324
+00:34:44,820 --> 00:34:53,820
+الجزية الأخيرة شباب
+
+325
+00:34:53,820 --> 00:34:59,060
+أنا بدي أثبت انه generated by ايه بس هدول هذه
+
+326
+00:34:59,060 --> 00:35:04,390
+خطوتينالخطوة الأولى انه كل واحد من هدول مختلف عن
+
+327
+00:35:04,390 --> 00:35:13,210
+التانى الخطوة التانية انه اي واحد من برا يعني اي
+
+328
+00:35:13,210 --> 00:35:19,970
+power اقل من الصفر او اكبر من ال N-1 لازم يكون
+
+329
+00:35:19,970 --> 00:35:25,510
+موجود هنا طيب now four
+
+330
+00:35:26,720 --> 00:35:35,540
+أني I أقل من ال N أكبر أو يساوي الصفر J أقل من ال
+
+331
+00:35:35,540 --> 00:35:51,020
+N أكبر أو يساوي الصفر if I لا يساوي J then I minus
+
+332
+00:35:51,020 --> 00:35:59,650
+J من ال Nوبين السلب N وال I minus J لا يساوي Zero
+
+333
+00:35:59,650 --> 00:36:02,810
+وبالتالي
+
+334
+00:36:02,810 --> 00:36:08,230
+A أس I minus J مش هيساوي ال identity
+
+335
+00:36:11,870 --> 00:36:15,810
+العدد الوحيد اللى ما ترفع ال a له يعطيك ال
+
+336
+00:36:15,810 --> 00:36:20,350
+identity من هو الصفر بس الصفر ال i minus ال j لا
+
+337
+00:36:20,350 --> 00:36:24,330
+تساوي ايه بمناته ال a أُس i minus ال j ما بيسويش
+
+338
+00:36:24,330 --> 00:36:31,630
+ال identity و فتالة a أُس i لا يساوي a أُس j يعني
+
+339
+00:36:31,630 --> 00:36:41,760
+if i لا يساوي jو ال I بين ال N و ال 0 و ال J بين
+
+340
+00:36:41,760 --> 00:36:48,320
+ال N و ال 0 المحصلة A أُس I and A أُس J are
+
+341
+00:36:48,320 --> 00:36:57,300
+distinct يعني هدولة كلهم مختلفين ولا واحد فيهم
+
+342
+00:36:57,300 --> 00:37:00,180
+بيساوي التاني now
+
+343
+00:37:02,790 --> 00:37:12,250
+إذا M أكبر أو يساوي الـ N أو M أصغر من الـ Zero ثم
+
+344
+00:37:12,250 --> 00:37:16,430
+بمعالجة
+
+345
+00:37:16,430 --> 00:37:21,590
+الـ Division الـ
+
+346
+00:37:21,590 --> 00:37:32,410
+M بدأ تساوي مثلا الـ Q شرط Nزاد R شرطة والـ R شرطة
+
+347
+00:37:32,410 --> 00:37:41,550
+بين الـ N و الـ 0 أي عدد غير هدول الـ 0,1,2,N,N-1
+
+348
+00:37:41,550 --> 00:37:48,250
+لما بدي أجسمه على الـ N هيدلر المين ضار بين مين؟
+
+349
+00:37:48,250 --> 00:37:55,810
+طيب ال A أُس M بدت ساوي A أُس Q شرطة N زاد R شرطة
+
+350
+00:37:55,810 --> 00:38:01,930
+A أُس N أُس Q شرطةفي ASR شرطة هذا بيساوي ال
+
+351
+00:38:01,930 --> 00:38:14,790
+identity في ASR شرطة ASR شرطة وهذا ينتمي يعني
+
+352
+00:38:14,790 --> 00:38:20,630
+بأي M أكبر من ال N أصغر من الصفر موجود هنا ولا مش
+
+353
+00:38:20,630 --> 00:38:26,070
+موجود هنايجب كل ال powers لل A اللي محصورين بين
+
+354
+00:38:26,070 --> 00:38:31,010
+الصفر و ال N-1 مختلفين و موجودين لكن ال powers
+
+355
+00:38:31,010 --> 00:38:37,090
+اللي جاب لل صفر و بعد ال N برضه مكررين بالسماء
+
+356
+00:38:37,090 --> 00:38:43,810
+الواق حدا من هدول النتيجة انه generated by A موجود
+
+357
+00:38:43,810 --> 00:38:44,630
+فيه بس هدول
+
+358
+00:38:49,050 --> 00:38:53,310
+طبعا لان انا عملت خطوتين اثبتت ان هدول موجودين و
+
+359
+00:38:53,310 --> 00:38:56,990
+اثبتت انه مش موجود غيرهم كيف اثبتت انهم موجودين
+
+360
+00:38:56,990 --> 00:39:02,450
+اثبتتهم distinct مختلفين مدام مختلفين مش مكررين و
+
+361
+00:39:02,450 --> 00:39:08,770
+بتالي كل واحد موجود بشخصه طبعا اللي غيرهم كل واحد
+
+362
+00:39:08,770 --> 00:39:15,210
+من ال powers اللي جابلي الصفر بعد الان موجود له
+
+363
+00:39:17,180 --> 00:39:23,000
+power مساوي في هذه المجموعة أو في السرد اللي موجود
+
+364
+00:39:23,000 --> 00:39:29,700
+قدامك وبالتالي بهذه الخطوة انا بكون انهيت النظرية
+
+365
+00:39:29,700 --> 00:39:36,700
+الاولى او نظرية 4-1 اي
+
+366
+00:39:36,700 --> 00:39:41,200
+سؤال اي
+
+367
+00:39:41,200 --> 00:39:41,980
+سؤال يا شباب
+
+368
+00:39:57,040 --> 00:40:06,240
+هنا؟ طيب اللي هي الجزء الأخير هذا هذا جزءين الجزء
+
+369
+00:40:06,240 --> 00:40:12,960
+الأول اللي هو المربع هذا الموجودين
+
+370
+00:40:12,960 --> 00:40:16,880
+مختلفين
+
+371
+00:40:16,880 --> 00:40:23,840
+يعني العناصر هذه أشملهامختلفة ماعدش بعدك تقول يا
+
+372
+00:40:23,840 --> 00:40:28,440
+عم ايه او السبعة او ايه او الستمانتاش زي بعض فانت
+
+373
+00:40:28,440 --> 00:40:33,440
+ليش حاططهم الخطوة التانية اللي المربع الأزرق
+
+374
+00:40:33,440 --> 00:40:41,400
+الواباقي
+
+375
+00:40:41,400 --> 00:40:51,200
+القوة مكررةماذا يعني؟ أي أُس آخر غير هدول موجود
+
+376
+00:40:51,200 --> 00:40:58,600
+لكناش بشكل تاني في two corollaries على هذه النظرية
+
+377
+00:40:58,600 --> 00:41:05,260
+corollary
+
+378
+00:41:05,260 --> 00:41:05,800
+واحد
+
+379
+00:41:15,560 --> 00:41:30,080
+إن order of a بيسوي order generated by a if
+
+380
+00:41:30,080 --> 00:41:33,120
+order
+
+381
+00:41:33,120 --> 00:41:37,720
+of a بيسوي infinity then order generated by a
+
+382
+00:41:37,720 --> 00:41:43,780
+عبارة عن order المجموعة هذه كده
+
+383
+00:41:43,780 --> 00:41:45,220
+عدد العناصر هنا يا شباب
+
+384
+00:41:48,100 --> 00:41:54,200
+final طيب لو كان order ال a بدي يساوي and then
+
+385
+00:41:54,200 --> 00:42:01,240
+order generated by a اللي هو ال order لل e a a
+
+386
+00:42:01,240 --> 00:42:05,320
+تربيه ل عند a and minus one كده عدد العناصر هنا
+
+387
+00:42:05,320 --> 00:42:13,280
+برضه and المحصرة ان order ال a بيساوي order
+
+388
+00:42:13,280 --> 00:42:15,720
+generated by a
+
+389
+00:42:30,400 --> 00:42:36,480
+caller 2 زمان
+
+390
+00:42:36,480 --> 00:42:44,920
+يا شباب لما كنا نشتغل على order
+
+391
+00:42:44,920 --> 00:42:50,480
+العنصر و نقول انه بيساوي n فأي power بيعطيك ان
+
+392
+00:42:50,480 --> 00:42:54,740
+العنصر بيساوي identity كنا نقول ان هذا ال power
+
+393
+00:42:54,740 --> 00:42:59,760
+أكبر من ال nهل جيت مش هنقول اكبر من الان هنقول ان
+
+394
+00:42:59,760 --> 00:43:04,760
+الان يقسمه هذا بذكرني في نظرية الاعداد لما شغلت
+
+395
+00:43:04,760 --> 00:43:07,940
+على الجريس common divisor في التعريف تبع الجريس
+
+396
+00:43:07,940 --> 00:43:13,760
+common divisor كان اي common divisor اخر الجريس
+
+397
+00:43:13,760 --> 00:43:18,280
+common divisor اكبر منه بعدين اصبح الجريس common
+
+398
+00:43:18,280 --> 00:43:25,720
+divisor مضاعف لهذا ال common divisor الاخر هنا نفس
+
+399
+00:43:25,720 --> 00:43:33,910
+الفكرةفإذا أردر الـ A هو N و A أُس K هو الـ
+
+400
+00:43:33,910 --> 00:43:43,770
+Identity فإن N يقسم الـ K إثبات سهل إذا
+
+401
+00:43:43,770 --> 00:43:50,250
+أردر ال A هو N و A أُس K هو الـ Identity فإن N
+
+402
+00:43:50,250 --> 00:43:51,510
+تقسم الـ K
+
+403
+00:43:57,750 --> 00:44:06,590
+كيف؟ النظرية مباشرة كمثال
+
+404
+00:44:06,590 --> 00:44:12,590
+سريع جامع من المحاضرة لو كان ال order لل A بدي
+
+405
+00:44:12,590 --> 00:44:18,390
+ساوي ستة ف generated by ال A عبارة عن ال identity
+
+406
+00:44:18,390 --> 00:44:25,930
+A A تربية A تكييب A أص أربعة A أص خمسةطبعا ليش
+
+407
+00:44:25,930 --> 00:44:31,810
+سموها Cyclic او زمر دوارة؟ هاي ال identity يا شباب
+
+408
+00:44:31,810 --> 00:44:41,800
+هان ال a هان ال a تربيه هان ال a تكيب ال a وص 4الـ
+
+409
+00:44:41,800 --> 00:44:47,240
+AOS 5 الـ Identity اللي هو AOS 6 بلف مرتين على AOS
+
+410
+00:44:47,240 --> 00:44:52,320
+7 الـ AOS 2 هو نفسه AOS 8 الـ AOS 3 عبارة عن الـ
+
+411
+00:44:52,320 --> 00:44:57,820
+AOS 9 الـ AOS 4 عبارة عن الـ AOS 10 و هكذا بتصير
+
+412
+00:44:57,820 --> 00:45:05,850
+القوة اشمالها بتلف في دائرةيعطيكوا العافية طبعا هي
+
+413
+00:45:05,850 --> 00:45:10,070
+كده احنا انهينا الجزء الاول في الوحدة الرابعة
+
+414
+00:45:10,070 --> 00:45:13,810
+وحاضرة جهة ان شاء الله هناخد الجزء التاني هناخد ال
+
+415
+00:45:13,810 --> 00:45:18,850
+fundamental theorem of cyclic groups يعطيكوا
+
+416
+00:45:18,850 --> 00:45:19,170
+العافية
+
diff --git a/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/RNahrP2LIYY_postprocess.srt b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/RNahrP2LIYY_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8ca89ac84e8a9787240bb3bf81d783d2c7caf21f
--- /dev/null
+++ b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/RNahrP2LIYY_postprocess.srt
@@ -0,0 +1,1820 @@
+1
+00:00:21,580 --> 00:00:26,400
+بسم الله الرحمن الرحيم في نهاية المحاضرة الماضية
+
+2
+00:00:26,400 --> 00:00:31,940
+أخدنا نظرية النظرية بتقول لو عندي رقمين S و T are
+
+3
+00:00:31,940 --> 00:00:37,970
+relatively prime يبقى ال U S T isomorphicللـ US
+
+4
+00:00:37,970 --> 00:00:43,470
+External Product مع من مع الـ UT يعني بقدر أكتب
+
+5
+00:00:43,470 --> 00:00:48,230
+الـ UN على صيغة External Product لمن؟ لـ two
+
+6
+00:00:48,230 --> 00:00:52,070
+groups لـ three groups لـ four groups وما إلى ذلك
+
+7
+00:00:52,070 --> 00:00:57,840
+بشرط يكون ال S و ال T are relatively a primeواخدنا
+
+8
+00:00:57,840 --> 00:01:06,060
+كمان نقطة ان U S T على S isomorphic ل U T وكذلك U
+
+9
+00:01:06,060 --> 00:01:12,820
+T ل U S T isomorphic ل U S وزيادة على ذلك رولر
+
+10
+00:01:12,820 --> 00:01:18,300
+عليها بنقول لو عندنا الرقم M واستطعنا ال M نكتبه
+
+11
+00:01:18,300 --> 00:01:23,100
+على الشكل التالي يبقى M بده يسوى N واحد
+
+12
+00:01:26,550 --> 00:01:32,090
+بحيث اي اتنين من هذه الأرقام are relatively prime
+
+13
+00:01:32,090 --> 00:01:37,790
+يعني ni مع ng اتنين are relatively prime لكل i لا
+
+14
+00:01:37,790 --> 00:01:43,440
+تساوي الجييبقى في هذه الحالة بقدر اقول ان ال UM
+
+15
+00:01:43,440 --> 00:01:54,000
+ايزو مورف كلمة ل ال UN 1 UN 2 UN 3 UN UN لغاية ال
+
+16
+00:01:54,000 --> 00:02:02,330
+UUNالان ان والله ان كهذه عملها ل ان كهذه يبقى هذه
+
+17
+00:02:02,330 --> 00:02:07,890
+بالصغيرة ان كهذه بالشكل اللي عندنا هذا طبعا الان
+
+18
+00:02:07,890 --> 00:02:13,210
+بدي الان اشتغل عمليابيقول لي هاي عندك اليوم 105
+
+19
+00:02:13,210 --> 00:02:17,990
+بتقدر تكتبها لي على الشكل اللي عندك كده؟ بمعنى هل
+
+20
+00:02:17,990 --> 00:02:23,410
+بتقدر تكتب ال 105 على شكل isomorphic ل two groups؟
+
+21
+00:02:23,410 --> 00:02:29,370
+الإجابة نعم نعم كيفي؟ بتدور على رقمين ال relative
+
+22
+00:02:29,370 --> 00:02:34,330
+to prime وحاصل ضربه ما يساومين 105 بتقدر تعطوني
+
+23
+00:02:34,330 --> 00:02:43,090
+رقمين؟وحد وعشرين وخمسة كويس يبقى هذا اللي هو عبارة
+
+24
+00:02:43,090 --> 00:02:54,010
+عن U اللي هو واحد وعشرين مضروبة في خمسة
+
+25
+00:02:54,010 --> 00:02:59,620
+يبقى هذه isomorphic ل U واحد وعشرينExternal
+
+26
+00:02:59,620 --> 00:03:11,640
+Product مع U5 كمان ال U 105 عبارة عن U الخمس عشر
+
+27
+00:03:11,640 --> 00:03:19,260
+في سبعة7 في 15% أو 5 يبقى هذا الكلام isomorphic
+
+28
+00:03:19,260 --> 00:03:27,060
+لمن؟ ل U 15 Extended like product مع مين؟ مع U 7
+
+29
+00:03:27,060 --> 00:03:34,950
+أجواح التالت منكم سمعت بيقولالـ U 105 هي عبارة عن
+
+30
+00:03:34,950 --> 00:03:41,990
+U خمسة و تلاتين في تلاتة بقوله كلامك صح يبقى هذه
+
+31
+00:03:41,990 --> 00:03:47,510
+isomorphic لـ U خمسة و تلاتين external product مع
+
+32
+00:03:47,510 --> 00:03:54,550
+U تلاتة هجوا على التالت قال الـ U 105 هذه الـ U
+
+33
+00:03:54,550 --> 00:04:03,020
+105 بدها تساوي الـ U تلاتة في خمسة في سبعةتلاتة و
+
+34
+00:04:03,020 --> 00:04:06,760
+كلهم تلاتة are relatively prime يبقى هذي
+
+35
+00:04:06,760 --> 00:04:12,360
+isomorphic لمين؟ ليه تلاتة external direct product
+
+36
+00:04:12,360 --> 00:04:17,500
+ليه خمسة external direct product لمين؟ ليه سبعة
+
+37
+00:04:17,500 --> 00:04:21,140
+يعني ليس بالضرورة أن يكون two groups و هنا ممكن
+
+38
+00:04:21,140 --> 00:04:27,850
+يكون تلاتة ممكن أربعةممكن يكون K من الأرقام اللي
+
+39
+00:04:27,850 --> 00:04:31,770
+كلها relative لأن اذا أخذت اي اتنين مع بعض بيكونوا
+
+40
+00:04:31,770 --> 00:04:35,890
+relatively main و relatively prime هذا بالنسبة
+
+41
+00:04:35,890 --> 00:04:40,950
+لمن؟ للنقطة الأولى و النقطة التالتة لو جهت للنقطة
+
+42
+00:04:40,950 --> 00:04:48,430
+الثانية و بدي أحسب لأي رقم منهم بدي أحسب U مثلا
+
+43
+00:04:48,430 --> 00:04:55,200
+خمس تاشر لمين لمية وخمسة يساويبتعرف مين عناصرها
+
+44
+00:04:55,200 --> 00:05:00,540
+المرة اللى فاتت اعطيناكوا تعريف لها وقلنا كل
+
+45
+00:05:00,540 --> 00:05:05,640
+العناصر X بحيث ان ال X modulo K بدي اعطيني الواحد
+
+46
+00:05:05,640 --> 00:05:10,220
+الصحيح تعريف كتبناه معاكوا المرة اللى فاتت اذا بدي
+
+47
+00:05:10,220 --> 00:05:17,680
+ادور على عناصر ال 105 واروح اجيب عناصر ال U15 على
+
+48
+00:05:17,680 --> 00:05:23,610
+105 اظن لو بدي اقعد اكتب عناصر ال 105 كلهمهتاخدنا
+
+49
+00:05:23,610 --> 00:05:27,350
+خمس دقايق و احنا قاعدين نستنتج مين اللي رتب ال
+
+50
+00:05:27,350 --> 00:05:33,530
+prime مع مية و خمسة لذلك بقول لأ بدي احسب مباشرة
+
+51
+00:05:33,530 --> 00:05:39,750
+فيو خمستاشر مية و خمسة الواحد منهم لإن الواحد ناقص
+
+52
+00:05:39,750 --> 00:05:45,190
+واحد يساوي زيرو مضاعفات الخمستاشر طيب الست عشر
+
+53
+00:05:45,190 --> 00:05:50,660
+منهميعني انت الخامس و الستاشر ده مانحط رقم قدامه و
+
+54
+00:05:50,660 --> 00:05:54,460
+لما تحط رقم قدامه تتأكد ان الرقم هذا relatively
+
+55
+00:05:54,460 --> 00:05:58,160
+prime على المية و خمسة ولا لا تمام؟ حتى يكون من
+
+56
+00:05:58,160 --> 00:06:02,200
+عناصر المية و خمسة الستاشر من عناصر المية و خمسة
+
+57
+00:06:02,200 --> 00:06:05,340
+لأنهم بيقسمش غير على اتنين و اربعة و تمانية وهذه
+
+58
+00:06:05,340 --> 00:06:10,480
+كلها relatively prime على المية و خمسة يبقى ستاشر
+
+59
+00:06:10,480 --> 00:06:16,330
+شريك واحد و تلاتين منهم؟وأحد وثلاثين وخمس عشر في
+
+60
+00:06:16,330 --> 00:06:20,630
+اتنين وثلاثين وواحد واحد وثلاثين والواحد وثلاثين
+
+61
+00:06:20,630 --> 00:06:24,210
+is a prime وبالتالي relative to the prime مع أي
+
+62
+00:06:24,210 --> 00:06:30,630
+منها طيب ستة واربعين ستة واربعين relative to the
+
+63
+00:06:30,630 --> 00:06:35,590
+prime مع المية وخمسة له اتنين في تلاتة وعشرين
+
+64
+00:06:35,590 --> 00:06:38,590
+اتنين relative to the prime والتلاتة وعشرين يبقى
+
+65
+00:06:38,590 --> 00:06:43,900
+فعلا الستة واربعين منهم طيب الواحد والستينانا بضيف
+
+66
+00:06:43,900 --> 00:06:48,380
+كله خمسة عشان تمام الواحد و ستين منهم لان واحد و
+
+67
+00:06:48,380 --> 00:06:54,060
+ستين is a prime كذلك طيب الأن لو جيت على الستة و
+
+68
+00:06:54,060 --> 00:07:00,300
+سبعين ستة و سبعين اه هذا لما نشيل من خمس عشر مضل
+
+69
+00:07:00,300 --> 00:07:03,580
+جداش مضل واحد كلام صحيح لكن هل الستة و سبعين
+
+70
+00:07:03,580 --> 00:07:08,000
+relative ل prime مع المية و خمسةعلى خمسة بتجيش
+
+71
+00:07:08,000 --> 00:07:13,920
+وعلى سبعة بتجيش وعلى تلاتة برضه بتجيش ويبقى الستة
+
+72
+00:07:13,920 --> 00:07:20,600
+وسبعين كذلك منهم طيب الواحد وتسعين خمسة وسبعين
+
+73
+00:07:20,600 --> 00:07:25,280
+وخمستاشر تسعين كمان واحد واحد وتسعين معاهم حط يعني
+
+74
+00:07:25,280 --> 00:07:33,410
+طب سبعة في تلاتاشر بقداش؟و 91 طب السبعة بتكسب على
+
+75
+00:07:33,410 --> 00:07:38,070
+سبعة و ال 105 بتكسب على سبعة يبقى ال 91 مش منهم
+
+76
+00:07:38,070 --> 00:07:43,910
+بدي كمان خمساش بكون فى التواصل 105,106 برا الرقم
+
+77
+00:07:43,910 --> 00:07:50,630
+انتهينا منهيبقى لا يوجد الا هذه الأرقام تمام شوفت
+
+78
+00:07:50,630 --> 00:07:55,630
+كيف بنحسبها اختارلي اي رقم من عندك من الأرقام اللي
+
+79
+00:07:55,630 --> 00:08:01,470
+هي اللي بتقسم 105 حتى نحسبها طيب هدها اللي هو 15
+
+80
+00:08:01,470 --> 00:08:11,800
+أليس isomorphic ليه 7لأن سبعة في خمستاشر بمية
+
+81
+00:08:11,800 --> 00:08:16,340
+وخمسة و احنا قلنا هنا ال U S على ST isomorphic
+
+82
+00:08:16,340 --> 00:08:21,360
+لمين؟ ل U T يبقى احنا هنا قلنا U خمستاشر و هذا
+
+83
+00:08:21,360 --> 00:08:25,000
+عبارة عن خمستاشر في سبعة يبقى isomorphic ل U سبعة
+
+84
+00:08:25,000 --> 00:08:30,170
+U سبعة كم عنصر فيه؟ست عناصر هدول ستة واحد اتنين
+
+85
+00:08:30,170 --> 00:08:34,490
+تلاتة اربع خمسة ستة كلها مناصعية مية لمية تمام
+
+86
+00:08:34,490 --> 00:08:39,450
+اختار لي كمار رقم اخر نحسبه لك بنفس الطريقة اللي
+
+87
+00:08:39,450 --> 00:08:48,470
+بدك هيها يومين نحسب تحسب كمان واحد بكفي يوم قداشر
+
+88
+00:08:48,470 --> 00:08:54,730
+خمسة و تلاتين خمسة و تلاتين انت جيبت اسهل حاجةطب
+
+89
+00:08:54,730 --> 00:08:57,270
+من انا ماعرف يعطيني الشمال اللى فيه يالله يا أبو
+
+90
+00:08:57,270 --> 00:09:02,170
+واحد اول واحد منهم ست و تلاتين الواحد اه معروف
+
+91
+00:09:02,170 --> 00:09:06,310
+اجنب عليه ست و تلاتين ست و تلاتين منهم ماختلف منهم
+
+92
+00:09:06,310 --> 00:09:11,550
+بص بص بص ست و تلاتين منهم ست و تلاتين اللى تبلى
+
+93
+00:09:11,550 --> 00:09:15,850
+prime مع مية و خمسة مش بيكسب مع تلاتة ست و تلاتين
+
+94
+00:09:15,850 --> 00:09:20,170
+ايه ده مش منهم حطه ع شجة يالله سبعين واحد و سبعين
+
+95
+00:09:20,170 --> 00:09:30,240
+واحد و سبعين منهمأكيد؟ اسمها يا راجل يعني
+
+96
+00:09:30,240 --> 00:09:37,060
+مش منهم طب انا بدأ أحط منهم هذا هو طب خلصنا ولا
+
+97
+00:09:37,060 --> 00:09:43,860
+فيه كمان؟ كده ايش بصير؟
+
+98
+00:09:43,860 --> 00:09:48,760
+بره يبقى ماعنديش إلا رقمين، تمام؟هذا اللي هو مين
+
+99
+00:09:48,760 --> 00:09:56,340
+اللي هو يو خمسة و تلاتين وهذا isomorphic لمن؟ ليهو
+
+100
+00:09:56,340 --> 00:10:02,120
+تلاتةلما قلنا هنا isomorphic لـ U تلاتة و هكذا
+
+101
+00:10:02,120 --> 00:10:07,060
+تمام؟ الخطر ان نجيب رقم كبير لان هذا سهل يعني جيب
+
+102
+00:10:07,060 --> 00:10:13,540
+عندي اعداد كتيرة زي ايش مثلا زي U مية و خمسة أبصار
+
+103
+00:10:13,540 --> 00:10:18,640
+قديش يلا اختارلك سبعة خمستاشر خمستاشر خدناه يبقى
+
+104
+00:10:18,640 --> 00:10:22,640
+بدك واحد و عشرين خمسة اه واحد و عشرين
+
+105
+00:10:44,500 --> 00:10:48,020
+مين الرقم اللي لو ضربت في خمسة و تلاتين بيعطيك مية
+
+106
+00:10:48,020 --> 00:10:52,880
+و خمسة اللي هو تلاتةمصبوط وبالتالي هذا isomorphic
+
+107
+00:10:52,880 --> 00:10:58,740
+ل U تلاتة و هكذا طيب لو قلنا رقم تاني U قداش قلتوا
+
+108
+00:10:58,740 --> 00:11:06,060
+واحد و عشرين واحد و عشرين يفجل واحد منهم بعدك
+
+109
+00:11:06,060 --> 00:11:11,880
+اتنين و عشرين منهم اكيد ولا لا مش اتنين و عشرين
+
+110
+00:11:11,880 --> 00:11:13,780
+اللي هو اتنين في احد و عشرين اللي في ال prime هو
+
+111
+00:11:13,780 --> 00:11:18,900
+عمية و خمسة اللي هو اتنين و عشرين طب تلاتة و
+
+112
+00:11:18,900 --> 00:11:27,800
+اربعين منهم21 في 2 ب 42 اضغط اضغط اضغط اضغط اضغط
+
+113
+00:11:27,800 --> 00:11:27,960
+اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط
+
+114
+00:11:27,960 --> 00:11:33,820
+اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط
+
+115
+00:11:33,820 --> 00:11:34,800
+اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط
+
+116
+00:11:34,800 --> 00:11:36,780
+اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط
+
+117
+00:11:36,780 --> 00:11:46,880
+اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغط اضغ
+
+118
+00:11:47,650 --> 00:11:53,250
+يبقى هذه اللي هي من الأربعة وستين طب لو ضربته في
+
+119
+00:11:53,250 --> 00:11:59,390
+أربعة بصير أربعة و تمانين و واحد خمسة و تمانين ليس
+
+120
+00:11:59,390 --> 00:12:01,850
+relatively prime مع مين معي مية و خمسة لإن هو
+
+121
+00:12:01,850 --> 00:12:06,910
+بيكسب على خمسة يبقى حطه على شجرة الآن بعد الأربعة
+
+122
+00:12:06,910 --> 00:12:13,350
+و تمانين لو ضربت في خمسة بصير المية و خمسةيبقى
+
+123
+00:12:13,350 --> 00:12:18,170
+انتهينا منه مظبوط يبقى لا يوجد عندي الا هذه
+
+124
+00:12:18,170 --> 00:12:25,630
+الأرقام وهذا isomorphic ليه خمسة تمام لإنه خمسة في
+
+125
+00:12:25,630 --> 00:12:31,050
+واحد وعشرين هو اللي بمية .. مية وخمسة تطلع يه خمسة
+
+126
+00:12:31,050 --> 00:12:35,070
+فيها واحد واتنين وتلاتة واربعة أربعة أرقام وماعناش
+
+127
+00:12:35,070 --> 00:12:41,100
+هنا إلا مين إلا أربعة أرقام ووضع الشغل هذا كدهيبقى
+
+128
+00:12:41,100 --> 00:12:46,320
+الـU اللى عندى جدر تجيبها isomorphic لمين لـgroups
+
+129
+00:12:46,320 --> 00:12:51,460
+او الـexternal product لماين لـgroups مختلفة ولسه
+
+130
+00:12:51,460 --> 00:12:57,100
+فى كلام فى هذا الموضوع الكلام ماشي بدي أنتقل من
+
+131
+00:12:57,100 --> 00:13:03,120
+الـU groups أحولها إلى isomorphic لـcyclic اللى هو
+
+132
+00:13:03,120 --> 00:13:09,240
+لـgroups اللى هى Z2 وZ3 وZ4 وZ5 وZ10 وZ30 وما إلى
+
+133
+00:13:09,240 --> 00:13:14,770
+ذلكفي عندنا .. اللي هو .. اللي هو قاعدة القاعدة
+
+134
+00:13:14,770 --> 00:13:19,430
+هذه طبعا برهنت في إحدى المراجع التي اعتمد عليها
+
+135
+00:13:19,430 --> 00:13:28,230
+هذا الكتاب ولذلك بدنا ناخدها كحقائق we have the
+
+136
+00:13:28,230 --> 00:13:36,170
+following notes أو the following facts دي عندي
+
+137
+00:13:36,170 --> 00:13:45,210
+حقائق مهمة جداالحقيقة الأولى ان ال U2 isomorphic
+
+138
+00:13:45,210 --> 00:13:51,430
+فقط لست لفش فيها الواحد إلا الواحد الصحيح and ال
+
+139
+00:13:51,430 --> 00:14:04,550
+U4 isomorphic لمام ل U isomorphic ل U2 تربيعأو
+
+140
+00:14:04,550 --> 00:14:13,770
+تساوية U2 ترابيع واللي هي isomorphic ل Z2 النقطة
+
+141
+00:14:13,770 --> 00:14:25,110
+الثانية ال U2 أُس N isomorphic ل Z2 External
+
+142
+00:14:25,110 --> 00:14:36,130
+Direct Product مع Zزد اتنين اوس ان ناقص اتنين اوس
+
+143
+00:14:36,130 --> 00:14:43,630
+ان fourن أكبر من أو تساوي تلاتة النقطة الثالثة
+
+144
+00:14:43,630 --> 00:14:51,230
+والاخيرة ال U P to the power in isomorphic لمين ل
+
+145
+00:14:51,230 --> 00:15:08,110
+Z P N ناقص P أس N ناقص واحد for P and D primeالـ P
+
+146
+00:15:08,110 --> 00:15:13,090
+and odd a prime so
+
+147
+00:15:13,090 --> 00:15:25,230
+we can write we can write ال U-groups ال U-groups
+
+148
+00:15:25,230 --> 00:15:31,490
+as an external direct product as an external
+
+149
+00:15:31,490 --> 00:15:36,970
+direct product
+
+150
+00:15:39,750 --> 00:15:52,890
+external product of cyclic groups نعطي
+
+151
+00:15:52,890 --> 00:15:59,750
+مثال example write
+
+152
+00:16:03,490 --> 00:16:13,370
+يو سبعمية وعشرين يو سبعمية وعشرين as
+
+153
+00:16:13,370 --> 00:16:21,070
+an external direct product as an external direct
+
+154
+00:16:21,070 --> 00:16:28,950
+product external
+
+155
+00:16:28,950 --> 00:16:31,610
+direct product of
+
+156
+00:16:34,130 --> 00:16:50,950
+cyclic growth نرجع
+
+157
+00:16:50,950 --> 00:16:56,230
+لهذه الحقائق مرة أخرى ونشوف كيف بدنا نشتغل عليها
+
+158
+00:16:56,230 --> 00:17:02,010
+أو ماذا نستفيد من هذه الحقائق الثلاثالنقطة الأولى
+
+159
+00:17:02,010 --> 00:17:08,350
+جال ال U2 isomorphic للعدد اللي هو واحد as a set
+
+160
+00:17:08,350 --> 00:17:12,510
+طبعا U2 مافيش فيها إلا man للعنصر اللي هو الواحد
+
+161
+00:17:12,510 --> 00:17:18,370
+يبقى هذا وضع طبيعي لل trivial case الحالة البديهية
+
+162
+00:17:18,370 --> 00:17:26,850
+U4 ل U2 تربية isomorphic ل Z2 لأن U4 فيها كام عنصر
+
+163
+00:17:28,400 --> 00:17:31,100
+تلاتة يو أربعة تلاتة يو أربعة تلاتة يو أربعة تلاتة
+
+164
+00:17:31,100 --> 00:17:31,580
+يو أربعة تلاتة يو أربعة تلاتة يو أربعة تلاتة يو
+
+165
+00:17:31,580 --> 00:17:33,480
+أربعة تلاتة يو أربعة تلاتة يو أربعة تلاتة يو أربعة
+
+166
+00:17:33,480 --> 00:17:36,180
+تلاتة يو أربعة تلاتة يو أربعة تلاتة يو أربعة تلاتة
+
+167
+00:17:36,180 --> 00:17:44,480
+يو أربعة تلاتة يو أربعة تلاتة يو أربعة
+
+168
+00:17:44,480 --> 00:17:45,540
+تلاتة يو أربعة تلاتة يو أربعة تلاتة يو أربعة تلاتة
+
+169
+00:17:45,540 --> 00:17:53,960
+أربعة تلاتة يو أربعة تلاتة
+
+170
+00:17:53,960 --> 00:18:00,350
+يو أربأتنين ناقص اتنين من الآن فصاعدا نشتغل بشكل
+
+171
+00:18:00,350 --> 00:18:06,610
+هذا يعني ال N ناقص اتنين هو أس لمين للإتنين الآن
+
+172
+00:18:06,610 --> 00:18:15,470
+ال UPN isomorphic لزد P أس N مطروحا منه P أس N
+
+173
+00:18:15,470 --> 00:18:21,030
+ناقص واحد وإنما يكون P prime و P أكبر من مين من
+
+174
+00:18:21,030 --> 00:18:24,620
+الإتنين يعني أنت تلاتة فصاعدايبقى هذا الكلام
+
+175
+00:18:24,620 --> 00:18:29,060
+قدامنا موجود بالشكل هنا هذا ايش فايديته؟ فايديته
+
+176
+00:18:29,060 --> 00:18:34,420
+ان ال group UN مهما كان شكلها ممكن اخليها
+
+177
+00:18:34,420 --> 00:18:40,300
+isomorphic لمين ل cyclic groups شو ال cyclic
+
+178
+00:18:40,300 --> 00:18:44,560
+groups اللي كلها بدي اكتبها بدلالة z والاعداد اللي
+
+179
+00:18:44,560 --> 00:18:50,160
+موجودة في z2 في z3 في z4 سهل حسابتهم لكن لو جتلى
+
+180
+00:18:50,160 --> 00:18:55,300
+720 بدي اكتب أرقامهامن هنا للدهر دوب نخلص و احنا
+
+181
+00:18:55,300 --> 00:18:59,320
+بدنا نجيب الألقام اللي relative ل prime مع مين مع
+
+182
+00:18:59,320 --> 00:19:04,000
+ال 720 قصتنا طويلة و حزينة لكن لما انا اكتبها بهذا
+
+183
+00:19:04,000 --> 00:19:08,480
+الشكل بداية ال Z بصير سهل التعامل معاها يبقى فائدة
+
+184
+00:19:08,480 --> 00:19:14,800
+هذه الحقيقة تسهيل التعامل مع مين مع ال U-groups
+
+185
+00:19:15,040 --> 00:19:20,560
+نعطيك مثال توضيحي على ذلك اللي اكتب ل U720 as a
+
+186
+00:19:20,560 --> 00:19:25,600
+product of cyclic aggregate بقى دي بقوله الحل
+
+187
+00:19:25,600 --> 00:19:31,060
+كتالة solution يبقى
+
+188
+00:19:31,060 --> 00:19:34,620
+انا بده اروح ل U720
+
+189
+00:19:35,530 --> 00:19:42,230
+هذه اللي بقدر اكتبها Uly بدي احطها على حاصل ضرب
+
+190
+00:19:42,230 --> 00:19:52,190
+اعداد لو قلتلك هذه عبارة عن 16×9×5 5×16 بـ 80 80×9
+
+191
+00:19:52,190 --> 00:19:58,260
+8×9 بـ 72 يعني 720يبقى هذا الكلام صحيح بالمائة
+
+192
+00:19:58,260 --> 00:20:05,660
+بالمائة هذه الان ايزو مورفك لمين ليه ستاشر
+
+193
+00:20:05,660 --> 00:20:11,260
+اكستيرنال دايكا product معاه تسعة اكستيرنال دايكا
+
+194
+00:20:11,260 --> 00:20:19,020
+product معاه خمسةطيب هذه مين هي ؟ أليست U2 أُص
+
+195
+00:20:19,020 --> 00:20:25,200
+أربع Extended product تلاتة ترابيع Extended
+
+196
+00:20:25,200 --> 00:20:33,380
+product ل U خمسة ست عشر اللي هي اتنين أُص أربع و
+
+197
+00:20:33,380 --> 00:20:36,880
+تلاتة ترابيع اللي هي تسعة و الخمسة زمان طيب السؤال
+
+198
+00:20:36,880 --> 00:20:41,880
+هو ليش كتبته زي هيك؟سوف أحاول أن أقوم بالتحويل إلى
+
+199
+00:20:41,880 --> 00:20:49,060
+الـ Cyclic Group. لكن عندما أحاول تحويلها بدلالة
+
+200
+00:20:49,060 --> 00:20:53,260
+الزد اللي لدي حسب القواعد اللي لدي بقدر أتأكد أن
+
+201
+00:20:53,260 --> 00:20:56,760
+كلامي مائة في المائة كله external product لل
+
+202
+00:20:56,760 --> 00:20:57,700
+Cyclic Group
+
+203
+00:21:02,550 --> 00:21:08,190
+ماشي ما احنا قلنا مشان هيك بدنا نبسط هالشغل هذه
+
+204
+00:21:08,190 --> 00:21:14,710
+بدنا نبسط هالشغل هذه و .. و نروح نكتبها بهذا الشكل
+
+205
+00:21:14,710 --> 00:21:22,410
+طيب يبقى لان كتبت الـ U 720 على الشكل اللي عندي
+
+206
+00:21:22,410 --> 00:21:29,400
+وهذه كتبتها بالشكل هذاالان هذه U2 أقصى 4 هنا U2
+
+207
+00:21:29,400 --> 00:21:35,560
+أقصى N و N أكبر من أو يسوى 3 ايزو مورفك لهذه إذا
+
+208
+00:21:35,560 --> 00:21:41,320
+بدي أقول له هذه ايزو مورفك لزد اتنين external
+
+209
+00:21:41,320 --> 00:21:47,700
+direct product مع زد بيقول لي مين اتنين هي زي ما
+
+210
+00:21:47,700 --> 00:21:53,650
+هيو ال n اللي هي اربعة ناقص اتنين يبقى طبقت هذه
+
+211
+00:21:53,650 --> 00:21:58,210
+على main على الأولى اللي هي اتنين اقص اربعة و
+
+212
+00:21:58,210 --> 00:22:04,370
+وصلنا هذه زى ال n التلاتة هذا prime مظبوط اذا
+
+213
+00:22:04,370 --> 00:22:09,490
+بيدروح لمين للحالة التالتة يبقى isomorphic لمين
+
+214
+00:22:09,490 --> 00:22:18,300
+لزىP التي هي ثلاثة و N اتنين ناقص ثلاثة أس اتنين
+
+215
+00:22:18,300 --> 00:22:23,920
+ناقص واحد ثم خلصنا هذه الامر وهناك استيقظنا ضايق
+
+216
+00:22:23,920 --> 00:22:30,900
+كتابة مع U خمسة اللي هي عبارة عن Z كده
+
+217
+00:22:30,900 --> 00:22:39,380
+اش قلنا ZP يعني Z خمسة أس واحد ناقص خمسة أس واحد
+
+218
+00:22:39,380 --> 00:22:46,500
+ناقص واحديبقى اوطة ويد مباشرة هذا P بثلاثة و P
+
+219
+00:22:46,500 --> 00:22:52,960
+بخمسة و N بواحد خمسة و S واحد ناقص واحد شوف هذه
+
+220
+00:22:52,960 --> 00:22:59,920
+ايش صارت صرت هذه Z دي اتنين external product مع Z
+
+221
+00:22:59,920 --> 00:23:06,470
+أبصر جداشأربعة ناقص اتنين باتنين اتنين تربيع باربع
+
+222
+00:23:06,470 --> 00:23:13,110
+يبقى هذه isomorphic لزاد اربع نجي لهذه تلاتة تربيع
+
+223
+00:23:13,110 --> 00:23:19,270
+تسعة و هنا تلاتة أس واحد تلاتة تسعة ناقص تلاتة
+
+224
+00:23:19,270 --> 00:23:26,640
+بستة يبقى isomorphic لزاد ستةوهذه الآن خمسة أس
+
+225
+00:23:26,640 --> 00:23:32,880
+زيرو بواحد وهنا خمسة أس واحد بخمسة ناقص واحد يبقى
+
+226
+00:23:32,880 --> 00:23:39,580
+زد أربع يبقى لان كتابة زد سبعمائة وعشرين على صيغة
+
+227
+00:23:39,580 --> 00:23:42,840
+زد اتنين external product لزد أربع external
+
+228
+00:23:42,840 --> 00:23:48,220
+product لزد ستة external product لزد أربع والاربع
+
+229
+00:23:48,220 --> 00:23:53,580
+cyclic groupsيبقى بناء عليه ال group اللي عندنا يو
+
+230
+00:23:53,580 --> 00:23:58,840
+سبعمية وعشرين جبت group بتعمل معاها isomorphism
+
+231
+00:23:58,840 --> 00:24:03,460
+وبالتالي خواص ال يو سبعمية وعشرين هي نفس الخواص
+
+232
+00:24:03,460 --> 00:24:06,940
+اللي عندنا يبقى بناء عليه لو جالي هاتلي element ال
+
+233
+00:24:06,940 --> 00:24:12,020
+order الو كذا في سبعمية وعشرينبروح على هذه هذه سهل
+
+234
+00:24:12,020 --> 00:24:16,840
+التعامل معاها بس ليه 720 صعب التعامل معاها إذا
+
+235
+00:24:16,840 --> 00:24:22,600
+بجيب هذه المكافئة لها ومن خلالها بقدر أجيب من اللي
+
+236
+00:24:22,600 --> 00:24:28,160
+هو ال element اللي ال order عنده يعطيني إياه في
+
+237
+00:24:28,160 --> 00:24:28,960
+السؤال
+
+238
+00:24:31,410 --> 00:24:38,470
+يبقى هذا الشكل وضع لتبسيط الحسابات العملية في ال
+
+239
+00:24:38,470 --> 00:24:42,270
+groups المختلفة
+
+240
+00:24:42,270 --> 00:24:49,730
+نعطيك
+
+241
+00:24:49,730 --> 00:24:55,230
+مثال على هذا الكلاموبالتالي المثال انت تعودت على
+
+242
+00:24:55,230 --> 00:25:00,750
+external product مكوّن من رقمين احنا هنعطيك سنة من
+
+243
+00:25:00,750 --> 00:25:06,910
+تلاتة من اربعة اكثر من ذلك يبقى باجي بقول example
+
+244
+00:25:06,910 --> 00:25:11,430
+how
+
+245
+00:25:11,430 --> 00:25:16,950
+many elements
+
+246
+00:25:16,950 --> 00:25:20,290
+of
+
+247
+00:25:20,290 --> 00:25:21,930
+order
+
+248
+00:25:51,070 --> 00:25:57,340
+سؤال مرة تانيةالسؤال بيقول ايه؟ بيقول اكم عنصر ال
+
+249
+00:25:57,340 --> 00:26:03,080
+order الو اتناش في ال U سبعمية و عشرين طبعا بدنا
+
+250
+00:26:03,080 --> 00:26:07,160
+نقعد نحسب كل element لحاله تطلع روحنا مش هنقدر
+
+251
+00:26:07,160 --> 00:26:10,800
+نحسبهم لكن هذه سبعمية و عشرين اللي جاتها
+
+252
+00:26:10,800 --> 00:26:15,580
+isomorphic لمين للي عندنا هذه بيبقى الحسابات هنا
+
+253
+00:26:15,580 --> 00:26:22,700
+أسهل كتير جدا من الحسابات هناك ايوةطب بتخلص بالله
+
+254
+00:26:22,700 --> 00:26:26,580
+في الساعتين اللي بتقدر تجيبهم؟ طب وكمان ساعتين من
+
+255
+00:26:26,580 --> 00:26:31,460
+9D واحسبلي كل ال elements اللي relatively prime مع
+
+256
+00:26:31,460 --> 00:26:38,780
+720 وادور عليهم من ال order اللي يساوي 12 انت حورر
+
+257
+00:26:38,780 --> 00:26:43,120
+جيب اللي بدك إياه أنا مش زعلان بس هتاخد وقت رهيب
+
+258
+00:26:43,120 --> 00:26:48,550
+جدا ساعتينك مش هيكفو لحساب اللي هو السؤال هذاالان
+
+259
+00:26:48,550 --> 00:26:57,170
+solution from the above example
+
+260
+00:26:58,670 --> 00:27:07,090
+من المثال اللي فوق الـ U720 أيزو مورفك ل Z2
+
+261
+00:27:07,090 --> 00:27:13,590
+Extended like product مع Z4 Extended like product
+
+262
+00:27:13,590 --> 00:27:19,470
+مع Z6 Extended like product مع Z4
+
+263
+00:27:22,860 --> 00:27:31,920
+أى element هنا ال order إليه يساوي اتناش يبقى بناء
+
+264
+00:27:31,920 --> 00:27:41,380
+عليه يبدو لو حسب فيه التانية يبقى so the number of
+
+265
+00:27:41,380 --> 00:27:52,660
+elements of order اتناش in u سبعمية او عشرين
+
+266
+00:27:54,980 --> 00:28:07,680
+equal of the number of elements of
+
+267
+00:28:07,680 --> 00:28:09,280
+order
+
+268
+00:28:26,260 --> 00:28:32,140
+طب احنا اخدنا اول نظرية في هذا section وكان مشان
+
+269
+00:28:32,140 --> 00:28:38,950
+اجيب ال order لل elementالمُركّب مثلا من مُركّبة
+
+270
+00:28:38,950 --> 00:28:43,370
+هنا بجيب ال list common multiple لمن ل ال two
+
+271
+00:28:43,370 --> 00:28:47,330
+orders اللي عنده وبالتالي بكون جابت ال order لل
+
+272
+00:28:47,330 --> 00:28:50,690
+element اللي موجود في ال external direct product
+
+273
+00:28:50,690 --> 00:28:57,210
+لذلك بروح أخد element هناو افترض ان هذا ال element
+
+274
+00:28:57,210 --> 00:29:03,010
+ال order له يساوي 12 و ابحث عن ال orders المختلفة
+
+275
+00:29:03,010 --> 00:29:09,530
+في هذه الحالة يبقى بداجي اقول له let ال a و ال b و
+
+276
+00:29:09,530 --> 00:29:18,610
+ال cوالدى موجودة في z2 similar product مع z4
+
+277
+00:29:18,610 --> 00:29:26,570
+similar product مع z6 similar product مع z4 such
+
+278
+00:29:26,570 --> 00:29:37,490
+that بحيث ان ال order لل a والb والc والd كله
+
+279
+00:29:37,490 --> 00:29:43,740
+بده يساوي كده؟ بده يساوي ماشيطيب الآن لما نقادي
+
+280
+00:29:43,740 --> 00:29:49,060
+لزد اتنين زد اتنين كم عنصر فيها اتنين يعني ال
+
+281
+00:29:49,060 --> 00:29:53,520
+order واحد وال order للعنصر التاني اتنين صح ولا لا
+
+282
+00:29:53,520 --> 00:29:57,980
+يبقى اي element في زد اتنين ال order له يا اما
+
+283
+00:29:57,980 --> 00:30:02,280
+واحد اللي هو ال identity يا اما اتنين طيب تاخدلي
+
+284
+00:30:02,280 --> 00:30:09,080
+زد اربع ال order اللي فيها واحد و كدهش و اتنين
+
+285
+00:30:09,740 --> 00:30:14,620
+تلاتة بتجسم الأربعة بتتكلم
+
+286
+00:30:14,620 --> 00:30:17,820
+على order بتتكلمش على العناصر اللي موجودة فيها
+
+287
+00:30:17,820 --> 00:30:20,900
+واحد واثنين واربعة واحد واثنين واربعة وفيش غيرهم
+
+288
+00:30:20,900 --> 00:30:25,140
+مظبوط لإن ال order لل element بيجسم لل order لل
+
+289
+00:30:25,140 --> 00:30:28,280
+group زد اربعة في اربعة عناصر اذا قوسم واحد اتنين
+
+290
+00:30:28,280 --> 00:30:33,550
+اربعة فقط لغير فيش حاجة اسمها تلاتةالعناصر اللي
+
+291
+00:30:33,550 --> 00:30:41,750
+موجودة في الـ Z6 واحد اتنين تلاتة ستة في شغلهم الـ
+
+292
+00:30:41,750 --> 00:30:46,770
+Z4 قبل قليل يبقى بدي أضع هذه المعلومة دي وبناء
+
+293
+00:30:46,770 --> 00:30:53,970
+عليه بدي أبدأ أحدد كم عنصر عندي يبقى هنا any
+
+294
+00:30:53,970 --> 00:30:55,850
+element
+
+295
+00:30:57,770 --> 00:31:09,390
+ن زدتر از اردت واحد واثنينAny element in Z4 has
+
+296
+00:31:09,390 --> 00:31:19,910
+order 1,2,4 أي element في Z6 has order 1,2,3,6 أي
+
+297
+00:31:19,910 --> 00:31:27,930
+element في Z4 في Z4 has element 1,2,4
+
+298
+00:31:30,490 --> 00:31:34,090
+طيب انا لما بدي اجيب ال order ل ال element بدي
+
+299
+00:31:34,090 --> 00:31:38,870
+اجيب ال least common multiples لمين للاربع orders
+
+300
+00:31:38,870 --> 00:31:43,390
+مش هيك بقول كويسة طلعلي ال order الأول واحد و
+
+301
+00:31:43,390 --> 00:31:48,290
+اتنين موجود مع هدول ولا لأ موجود مع هذه موجود مع
+
+302
+00:31:48,290 --> 00:31:53,850
+هذهيعني وجود إيش بس بيخر بشكل بيخليها كبيرة يبقى
+
+303
+00:31:53,850 --> 00:31:58,330
+في الحقيقة أنا بدي أبحث بس عن A وB وC تمام؟ لكن
+
+304
+00:31:58,330 --> 00:32:01,970
+هداك بدي أخليه في حسابي مش باهيم له يبقى الذي
+
+305
+00:32:01,970 --> 00:32:06,390
+يتحكم في ال order اللي هو ال 12 اللي هو التلاتة
+
+306
+00:32:06,390 --> 00:32:12,520
+الأخيرات هدولوالهدا 1 و 2 مش مشكلة يبقى عندي
+
+307
+00:32:12,520 --> 00:32:18,140
+عنصرين بدخلهم في الحساب بعد ذلك يبقى بدالي لل 2 و
+
+308
+00:32:18,140 --> 00:32:23,420
+4 اللي عندي يبقى هنا ال element ايه ال order ايه 1
+
+309
+00:32:23,420 --> 00:32:31,450
+و 2الـ element بي 1,2,4 ال element c 1,2,3,6 ال
+
+310
+00:32:31,450 --> 00:32:38,570
+element 4 1,2,4 طب الآن انا بدي ادور ال main ال
+
+311
+00:32:38,570 --> 00:32:42,910
+least common multiple اللي هم بده يعطيني قداش 12
+
+312
+00:32:42,910 --> 00:32:49,670
+وبحيث ها طلعلي هناالان الواحد و الاتنين مكررة
+
+313
+00:32:49,670 --> 00:32:54,210
+مالواحد و اتنين يبقى لا قيمة لها مظبوط يبقى هنا
+
+314
+00:32:54,210 --> 00:32:58,690
+ضال عند مينالاربعة يبقى لو كان ال order اللى بيه
+
+315
+00:32:58,690 --> 00:33:04,170
+بده يساوي الاربعة و ال order اللى يسيه كان تلاتة
+
+316
+00:33:04,170 --> 00:33:08,830
+او ستة طب ليش تلاتة او ستة؟ لأن تلاتة او اربعة
+
+317
+00:33:08,830 --> 00:33:12,730
+ليسكم ال multiple اللي قلهم كداش اتناش والستة
+
+318
+00:33:12,730 --> 00:33:15,290
+والاربعة ليسكم ال multiple اللي قلهم كمان مين
+
+319
+00:33:15,290 --> 00:33:21,820
+اتناش يبقى هذا اللى يساه يتحكمفى من؟ فى ال order
+
+320
+00:33:21,820 --> 00:33:25,900
+طب و اللى تحت هذا لتحت ما هو داخل فى الحساب لإن
+
+321
+00:33:25,900 --> 00:33:30,920
+واحد اتنين هي موجودة والاربعة موجودة هنا يبقى ال D
+
+322
+00:33:30,920 --> 00:33:36,140
+مش هتأثر عندي مش هتجيبلي معلومات جديدة يبقى باضيفة
+
+323
+00:33:36,140 --> 00:33:41,240
+تحصيل حاصل هي الحالة الأولى يبقى الحالة الأولى
+
+324
+00:33:41,240 --> 00:33:44,040
+اللى ال order ال list common multiple اللى بده
+
+325
+00:33:44,040 --> 00:33:48,460
+يطلع اتناش خد الحالة التانيةممكن يكون ال order
+
+326
+00:33:48,460 --> 00:33:54,180
+اللي دي هو أربعة و ال C له تلاتة و ستة مش هيك وارد
+
+327
+00:33:54,180 --> 00:33:59,180
+تمام و الباقي اللي هو اللي بيتحصيل حاصل بسيط تمام
+
+328
+00:33:59,180 --> 00:34:03,200
+يبقى بدنا نيجي نشتغل الشغل اللي عندنا هادي
+
+329
+00:34:13,770 --> 00:34:18,010
+الان قلنا بالنسبة للأولى اللي اسمها multiple تحصيل
+
+330
+00:34:18,010 --> 00:34:24,210
+حصل يبقى دي مش هتدخل في الحساب عندنا يبقى we have
+
+331
+00:34:24,210 --> 00:34:30,050
+two cases
+
+332
+00:34:30,050 --> 00:34:35,910
+هي عندي حالتين الحالة الأولى ان ال order لل B بده
+
+333
+00:34:35,910 --> 00:34:41,150
+يسوى الأربعة و ال order ل C يا إما تلاتة يا إما
+
+334
+00:34:41,150 --> 00:34:45,350
+ستةيبقى تلاتة واربعة الـ least common multiple
+
+335
+00:34:45,350 --> 00:34:48,730
+يبقى 12 الستة والاربعة ال least common multiple
+
+336
+00:34:48,730 --> 00:34:53,290
+يبقى 12 يبقى هدول يجيبولي ال element ال order يسوى
+
+337
+00:34:53,290 --> 00:35:00,190
+كم؟ ال 12 طب أكم انصر في زيد أربعة ال order يسوى
+
+338
+00:35:00,190 --> 00:35:08,630
+أربعة؟ بسأتنين هو الواحد والتلاتة الواحد والتلاتة
+
+339
+00:35:08,630 --> 00:35:14,850
+في زد أربعة ال order يساوي مين؟ الاربعة يمجى بيه
+
+340
+00:35:14,850 --> 00:35:20,890
+هنا يا بدها تساوي واحد يا بدها تساوي تلاتة طيب سي
+
+341
+00:35:20,890 --> 00:35:27,370
+هنا بدها تساوي ال order له تلاتة او ال order له
+
+342
+00:35:27,370 --> 00:35:34,150
+ستة اظن الواحد ال order له ستة طب و اتنين طب و
+
+343
+00:35:34,150 --> 00:35:41,700
+الأربعةالأردر ماذا؟ ثلاثة ثلاثة؟ طب و الست؟ واحد
+
+344
+00:35:41,700 --> 00:35:45,780
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+345
+00:35:45,780 --> 00:35:48,240
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+346
+00:35:48,240 --> 00:35:48,920
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+347
+00:35:48,920 --> 00:35:49,520
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+348
+00:35:49,520 --> 00:35:50,300
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+349
+00:35:50,300 --> 00:35:50,340
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+350
+00:35:50,340 --> 00:35:53,380
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+351
+00:35:53,380 --> 00:35:58,440
+واحد، واحد، واحد، واحد، واحد، واحد، واحد، واحد،
+
+352
+00:35:58,440 --> 00:36:03,500
+واحد،
+
+353
+00:36:03,500 --> 00:36:04,480
+وا
+
+354
+00:36:11,410 --> 00:36:17,450
+الرقم يا باخد C بواحد يا باخد الست يعني اتنين هذا
+
+355
+00:36:17,450 --> 00:36:21,650
+ال component يا بتكون واحد يا بتكون ست صفر ماشي
+
+356
+00:36:21,650 --> 00:36:25,790
+الحاجة بتزعلان ليه هذا
+
+357
+00:36:25,790 --> 00:36:31,450
+احنا بنحكي الآن في order كبير مش لحاله تمامأحنا
+
+358
+00:36:31,450 --> 00:36:36,310
+بنحكي الآن ال order لل element بده يساوي ستة مين
+
+359
+00:36:36,310 --> 00:36:40,550
+ال elements اللي ال order اللي هم يساوي .. ده مش
+
+360
+00:36:40,550 --> 00:36:46,770
+ستة .. ده خمسة .. ده خمسة الواحد و الخمسة ال order
+
+361
+00:36:46,770 --> 00:36:52,470
+اللي هم ستة صحيح؟ اتنين و الأربعة هم ال order اللي
+
+362
+00:36:52,470 --> 00:37:01,030
+هم تلاتة طيب هذا ال B و ال C طب و ال D؟لا خدها أي
+
+363
+00:37:01,030 --> 00:37:11,890
+شيء اي نعم and ادي arbitrary يعني خدها زي ما بدك
+
+364
+00:37:12,760 --> 00:37:17,280
+كويس؟ طيب لما اخدها زي المبدأ بقول اخد الأربعة لما
+
+365
+00:37:17,280 --> 00:37:21,700
+انا اخد يعني الأربعة مش هيتغير ليش؟ لأن ال order
+
+366
+00:37:21,700 --> 00:37:24,960
+سبعة هي واحد، هي اتنين، هي أربعة هي وماخدناهم
+
+367
+00:37:24,960 --> 00:37:31,340
+معاهدي يعني مش هيجيبولي إيش؟ ليش دي؟ يبقى الآن the
+
+368
+00:37:31,340 --> 00:37:40,380
+number of elements of order
+
+369
+00:37:45,070 --> 00:37:52,890
+الحين ال A كم عنصر فيها؟ اتنين ال B كم عنصر؟ اتنين
+
+370
+00:37:52,890 --> 00:37:59,590
+ال C كم عنصر؟ اربعة ال D خد زي ما بدك اجدش اربعة
+
+371
+00:37:59,590 --> 00:38:04,370
+يبقى أربعة في أربعة في ستاشر في أربعة باربعة وستين
+
+372
+00:38:04,370 --> 00:38:11,490
+يبقى اربعة وستين elementهذول ال order يساوي 12 لو
+
+373
+00:38:11,490 --> 00:38:12,090
+كان
+
+374
+00:38:19,370 --> 00:38:23,850
+هدول ال orders لكن انا كام عنصر هدول عندى اربعة نص
+
+375
+00:38:23,850 --> 00:38:27,330
+خد اللى بدك اياه ال orders واحد واتنين واربعة زى
+
+376
+00:38:27,330 --> 00:38:30,630
+الواحد واتنين واربعة اذا هدول قلت مصفع شجعون
+
+377
+00:38:30,630 --> 00:38:36,590
+اشتغلت في هدول تمام هدول الان هذا بضيف تحصيل حاصل
+
+378
+00:38:36,590 --> 00:38:40,590
+يعني ايش ما كان يكون كان ال zero كان الواحد كان
+
+379
+00:38:40,590 --> 00:38:44,350
+الاتنين كان التلاتة لن يغير في النتيجة شيئا وكوان
+
+380
+00:38:44,350 --> 00:38:48,990
+انت بتكتب element مكون من اربع مركباتيعني عندك
+
+381
+00:38:48,990 --> 00:38:54,110
+بدائل اتنين لل A وبدائل اتنين لل B لأن ال order
+
+382
+00:38:54,110 --> 00:38:59,190
+يسوى اربعة وعندك اربع بدائل لل C واربع بدائل لل D
+
+383
+00:38:59,190 --> 00:39:03,210
+صحيح ولا لا؟ يبقى على بعضهم كله مصيره جداش اربعة
+
+384
+00:39:03,210 --> 00:39:09,590
+وستين عنصر هذا هي الحالة الأولى الحالة التانيةال
+
+385
+00:39:09,590 --> 00:39:16,150
+order اللى دى ممكن يكون اربعة and ال order لسه يا
+
+386
+00:39:16,150 --> 00:39:26,910
+اما تلاتة يا اما ستة يبقى
+
+387
+00:39:26,910 --> 00:39:31,650
+في هذه الحالة لما ال order اللى دى بدى يساوي اربعة
+
+388
+00:39:31,650 --> 00:39:38,600
+اكم element بيعطينا اتنين مظبوطيبقى هنا في عندي
+
+389
+00:39:38,600 --> 00:39:46,080
+اتنين elements طيب لما يكون هنا في عندي جداش؟
+
+390
+00:39:46,080 --> 00:39:52,440
+جداش؟ اربع elements طيب
+
+391
+00:39:52,440 --> 00:39:59,200
+نيجي لل a جداش؟ اربع elements اتنين elements نيجي
+
+392
+00:39:59,200 --> 00:40:03,240
+لل b جداش عندي؟ اتنين elements
+
+393
+00:40:05,800 --> 00:40:12,760
+يبقى صغر الآن اتنين اخدناها
+
+394
+00:40:12,760 --> 00:40:16,240
+اربعة مع الخطوة اللي قبلها اه اخدناها اربعة مع
+
+395
+00:40:16,240 --> 00:40:19,580
+الخطوة اللي قبلها لاش نكررها لان التكرار هذا بجيب
+
+396
+00:40:19,580 --> 00:40:24,300
+شغلات اكتر من اللازم يبقى so we have العنصر
+
+397
+00:40:24,300 --> 00:40:28,400
+الأولاني اتنين والتاني اربعة واللي بعده اتنين
+
+398
+00:40:28,400 --> 00:40:33,370
+واللي بعده اتنينيبقى تمانية في أربعة بجداش بتنين و
+
+399
+00:40:33,370 --> 00:40:41,650
+تلاتين element of order اللي هو أتناشر طب إذا على
+
+400
+00:40:41,650 --> 00:40:43,210
+بعضهم جداش
+
+401
+00:40:45,410 --> 00:40:52,270
+يو سبعمية وعشرين has اللي هو قداش في الأول اربعة
+
+402
+00:40:52,270 --> 00:41:00,330
+وستين زائد اتنين وتلاتين ويساوي ستة وتسعين element
+
+403
+00:41:00,330 --> 00:41:08,010
+of order اللي هو اتناشر
+
+404
+00:41:17,690 --> 00:41:22,970
+يبقى بناء عليها من الآن فصاعدا لو قاللي شوف لقداش
+
+405
+00:41:22,970 --> 00:41:29,050
+عدد العناصر اللي ال order لهم يساوية رقم معين في
+
+406
+00:41:29,050 --> 00:41:34,770
+UN ال UN ال N مينما كانت تكون بدي احولها الى مين؟
+
+407
+00:41:34,770 --> 00:41:41,160
+بدي احولها الى ال cyclic groupsمدالة z2 و z3 و z4
+
+408
+00:41:41,160 --> 00:41:45,840
+و z5 و z6 و بيبقوا أحسب من مين من هذه ال z اللي هو
+
+409
+00:41:45,840 --> 00:41:51,000
+هذه العناصر على هيك بيكون انتهى ال section طيب في
+
+410
+00:41:51,000 --> 00:41:57,800
+عندك سؤال زي سؤال تلاتة بيقول ما يأتي سؤال
+
+411
+00:41:57,800 --> 00:42:06,820
+تلاتةبقول الـ G group with identity والـ H بيه
+
+412
+00:42:06,820 --> 00:42:12,440
+group with identity prove that الـ G isomorphic
+
+413
+00:42:12,440 --> 00:42:20,340
+الـ G isomorphic لمين؟ لل external direct product
+
+414
+00:42:20,730 --> 00:42:26,850
+للـ G external like product مع ال identity element
+
+415
+00:42:26,850 --> 00:42:38,850
+تبع ال H and ال H is isomorphic لمن؟
+
+416
+00:42:38,850 --> 00:42:45,570
+لل identity تبع ال G external like product مع من؟
+
+417
+00:42:45,570 --> 00:42:48,350
+مع ال H
+
+418
+00:42:56,050 --> 00:43:04,540
+خلّي بالك أني أنا عندي الـ G و ال H are groupsمش
+
+419
+00:43:04,540 --> 00:43:07,580
+هتقول الـH subgroup من G اللي مالعاش علاقة هذي
+
+420
+00:43:07,580 --> 00:43:12,880
+group و هذي group تاني بقول اثبت ان الـG هي
+
+421
+00:43:12,880 --> 00:43:17,580
+isomorphic لمين لـG وال external direct product
+
+422
+00:43:17,580 --> 00:43:23,680
+يبقى هنا بتروح اعرفله Phi من الـG الى الـG
+
+423
+00:43:23,680 --> 00:43:31,520
+external direct product مع E H Piفاي اف جي ممكن
+
+424
+00:43:31,520 --> 00:43:37,900
+اخد صورته هنا ممكن اخدها جي والاي تبع ال H
+
+425
+00:43:44,530 --> 00:43:52,370
+لو جيت أخدت بدل في أخدت مثلا اللي هو ال F من ال H
+
+426
+00:43:52,370 --> 00:44:01,290
+إلى ال identity element تبع ال G across ال H by ال
+
+427
+00:44:01,290 --> 00:44:09,030
+F of H بده يساوي ال external direct product لل
+
+428
+00:44:09,030 --> 00:44:16,920
+E تبع ال Gللـ A تابع الـ G و H بالشكل اللي عندنا
+
+429
+00:44:16,920 --> 00:44:25,020
+هنا او بلاش هون هذا ايه جوز وهذا ايه جي و H جوز
+
+430
+00:44:25,020 --> 00:44:29,540
+مباشرة يبقى بدنا نثبت من هذا طبعا إذا أثبتنا الأول
+
+431
+00:44:29,540 --> 00:44:36,510
+بصير التاني حرفيا زيهطيب لو جيت له الأولى يبقى بدي
+
+432
+00:44:36,510 --> 00:44:41,830
+اثبت له ان الـ Phi is one to one يبقى بدي اقول له
+
+433
+00:44:41,830 --> 00:44:50,310
+assume افترض ان Phi of G1 بدي ساوي Phi of G2 هذا
+
+434
+00:44:50,310 --> 00:44:56,050
+معناته ان الـ G1 و ال identity تبع ال H بدي ساوي
+
+435
+00:44:56,050 --> 00:45:03,780
+G2 و ال identity تبع ال Hطبعا two order pair are
+
+436
+00:45:03,780 --> 00:45:07,220
+equal يبقى المراكبة الأولى سواء المراكبة الأولى أو
+
+437
+00:45:07,220 --> 00:45:12,540
+المراكبة الثانية سواء مين المراكبة الثانية يبقى G1
+
+438
+00:45:12,540 --> 00:45:19,400
+سواء G2 وهذا الـEH هو نفسه الـEH أظن و هو المطلوب
+
+439
+00:45:19,400 --> 00:45:26,030
+الآن مداجي أثبت له أن فاي is ontoيبقى بالدرجة
+
+440
+00:45:26,030 --> 00:45:32,190
+اقوله افترض ان ال X موجود في ال G external product
+
+441
+00:45:32,190 --> 00:45:40,210
+مع ال identity تبع ال H ثم شكل ال X هذا بده يساوي
+
+442
+00:45:40,210 --> 00:45:47,120
+element من G و ال identity element تبع ال Hطيب هذا
+
+443
+00:45:47,120 --> 00:45:53,980
+حسب التعريف هو مين؟ Phi of G لذلك Phi is أنتوا بقى
+
+444
+00:45:53,980 --> 00:45:59,380
+لدينا Phi is an isomorphism يبقى Phi is an
+
+445
+00:45:59,380 --> 00:46:09,480
+isomorphism يبقى بدي أقعد أخد ال Phi of G و G2
+
+446
+00:46:09,480 --> 00:46:15,750
+الشكل اللي عندنا هنا يبقى هذا الكلام بده يساوياللي
+
+447
+00:46:15,750 --> 00:46:24,070
+هو مين اللي هو five of g one g two بده يساوي اللي
+
+448
+00:46:24,070 --> 00:46:33,170
+هو g one g two وال إيه hهذا الكلام بده يساوي بده
+
+449
+00:46:33,170 --> 00:46:39,370
+احاول اكتب هذا على صيغة حاصل ضرب قوسين اذا لو جيت
+
+450
+00:46:39,370 --> 00:46:49,530
+قلت جي واحد مع ال E H وهنا جي اتنين مع ال E H لو
+
+451
+00:46:49,530 --> 00:46:53,370
+ضربت ضرب component wise يبقى بيصير جي ون جي تون
+
+452
+00:46:53,370 --> 00:46:59,060
+وال E H في ال E H هي بال E H itselfيبقى هذا الكلام
+
+453
+00:46:59,060 --> 00:47:07,300
+بده يساوي هذا Phi of G1 و هذا Phi of G2 يبقى هنا
+
+454
+00:47:07,300 --> 00:47:17,080
+Phi is an isomorphism وهكذا بالنسبة لمن؟ بالنسبة
+
+455
+00:47:17,080 --> 00:47:17,900
+للثاني
+
diff --git a/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/TxbkO72dNBs_postprocess.srt b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/TxbkO72dNBs_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..944cfb404576ff516c8bc387c94551697ae2cf2e
--- /dev/null
+++ b/PL9fwy3NUQKwZKOpj354PRgwYPWWgxchnI/TxbkO72dNBs_postprocess.srt
@@ -0,0 +1,1700 @@
+1
+00:00:22,350 --> 00:00:26,430
+بنكمل برهانة اللمة اللى ابتدأنا فيه المحاضرة
+
+2
+00:00:26,430 --> 00:00:30,950
+الماضية طبعا اللمة هذه عبارة عن ثمانى نقاط برهانة
+
+3
+00:00:30,950 --> 00:00:36,090
+منها اللى هو خمس نقاط بنجي الأن لنقطة السادسة
+
+4
+00:00:36,090 --> 00:00:43,270
+النقطة رقم ستة بيقوللي ان ال order لل A H يساوي ال
+
+5
+00:00:43,270 --> 00:00:50,110
+order لل B Hالمقصود من ذلك انه لو عملت اي left
+
+6
+00:00:50,110 --> 00:00:54,430
+coset او right coset لsub group من ال group
+
+7
+00:00:54,430 --> 00:00:59,690
+الأساسية بدي يطلع في كل left coset نفس العدد من
+
+8
+00:00:59,690 --> 00:01:03,810
+العناصر او لو كانت right cosets بضبط بدي يطلع في
+
+9
+00:01:03,810 --> 00:01:09,290
+كل تنتين او كلهم هيطلع في كل واحدة فيهم نفس العدد
+
+10
+00:01:09,290 --> 00:01:14,770
+من العناصريبقى order للـ A H يسوى order للـ B H
+
+11
+00:01:14,770 --> 00:01:20,510
+لكل الـ A والـ B الموجودة في group G يبقى هذا صحيح
+
+12
+00:01:20,510 --> 00:01:27,460
+لكل الـ A والـ B الموجودة في group Gمشان نثبت ان
+
+13
+00:01:27,460 --> 00:01:30,700
+ال order ل group يسوي ال order ل group قولنا يكفي
+
+14
+00:01:30,700 --> 00:01:33,940
+نثبت انه في function ما بين الاتنين و ال function
+
+15
+00:01:33,940 --> 00:01:38,000
+تبقى one to one and unto هذا بيعطيني ان عدد
+
+16
+00:01:38,000 --> 00:01:44,140
+العناصر في الأولى يسوي عدد العناصر في الثانية لذلك
+
+17
+00:01:44,140 --> 00:01:47,940
+بدي اجي ابرهن هذه النقطة بقوله define
+
+18
+00:01:51,950 --> 00:02:01,920
+فاي من ال A H الى ال B H بايالـ FI لما تأثر على
+
+19
+00:02:01,920 --> 00:02:07,520
+ايه بدي أخد element من H وليكن AH بوديها لل BH
+
+20
+00:02:07,520 --> 00:02:15,440
+يبقى بده يساوي BH الكلام هذا صحيح لكل ال H اللي
+
+21
+00:02:15,440 --> 00:02:20,920
+موجودة وين موجودة في H بدي نثبت هذه one to one and
+
+22
+00:02:20,920 --> 00:02:30,880
+untoيبقى باجي بقوله في هذه الحالة Phi is one to
+
+23
+00:02:30,880 --> 00:02:39,040
+one Assume بروح ناخد صورتين متساويتين أن Phi of A
+
+24
+00:02:39,040 --> 00:02:48,390
+H1 يسوى Phi of A H2بدي احاول اثبت ان الـ AH1 يساوي
+
+25
+00:02:48,390 --> 00:02:53,570
+الـ PH1 يساوي الـ PH2 ان تم ذلك يبقى بيصير PH1 to
+
+26
+00:02:53,570 --> 00:03:00,070
+PH1 بناء على التعريف يبقى هذا بيساوي BH1 وهذا
+
+27
+00:03:00,070 --> 00:03:08,310
+بيساوي BH2 بالـ left cancellation law هذه بتعطينا
+
+28
+00:03:15,660 --> 00:03:22,020
+لو ضربت الطرفين من جهتي اليسار في a بيصير a h1
+
+29
+00:03:22,020 --> 00:03:27,420
+يساوي a h2 وبالتالي فاي is one to one
+
+30
+00:03:33,850 --> 00:03:41,170
+بتروح و أخد element من ال code main و أثبت إنه أصل
+
+31
+00:03:41,170 --> 00:03:45,590
+وين في ال domain يبقى بدي أجي على ال BH بدي أخد
+
+32
+00:03:45,590 --> 00:03:50,430
+element منها و أثبت إن هذا ال element له أصل في
+
+33
+00:03:50,430 --> 00:03:57,330
+main في ال AH يبقى باجي بقول افترض إن X موجود وين
+
+34
+00:03:57,330 --> 00:04:03,350
+موجود في ال BH تمام؟
+
+35
+00:04:03,690 --> 00:04:13,470
+يبقى then ال X هذا بده يساوي BH for some H اللي
+
+36
+00:04:13,470 --> 00:04:22,190
+belongs to man to H طيب هذا أليس هو BH طبقا اللي
+
+37
+00:04:22,190 --> 00:04:28,900
+التعريف هو Phi of Hمعنى هذا الكلام ان فاي is on
+
+38
+00:04:28,900 --> 00:04:32,520
+two خلاص
+
+39
+00:04:32,520 --> 00:04:40,800
+ننتهي هنا منها يبقى هنا Sir فاي is one to one and
+
+40
+00:04:40,800 --> 00:04:50,090
+on twoوهذا يتطلب ان ال order لله هو order لل بيه
+
+41
+00:04:50,090 --> 00:04:55,610
+يبقى من الآن فصاعدا لما ناخد subgroup من ال group
+
+42
+00:04:55,610 --> 00:05:00,970
+جي و اضرب اي element من جي في هذا اله من جهة
+
+43
+00:05:00,970 --> 00:05:05,690
+الشمال او جهة اليمينان شاء الله يطلع عنده مائة
+
+44
+00:05:05,690 --> 00:05:11,030
+كاسات يبقى المية كل واحدة فيها نفس العدد من
+
+45
+00:05:11,030 --> 00:05:15,210
+العناصر فيها عشرين يبقى التانية فيها عشرين التالتة
+
+46
+00:05:15,210 --> 00:05:20,010
+عشرين إلى أخره وهكذا هذا بالنسبة للنقطة رقم ستة
+
+47
+00:05:20,010 --> 00:05:26,770
+بنجلة النقطة رقم سبعةيبقى النقطة رقم سبعة بتقول إن
+
+48
+00:05:26,770 --> 00:05:35,690
+الـ A H بده يساوي الـ H A if and only if الـ H بده
+
+49
+00:05:35,690 --> 00:05:44,610
+يساوي A H A inverse بدنا نبرهن صحة هذا الكلام ل
+
+50
+00:05:44,610 --> 00:05:51,030
+proveخلّي ابقى لك هنا الان الوضع سيكون في اتجاهين
+
+51
+00:05:51,030 --> 00:05:56,350
+لكن ممكن نجيب الاتجاهين مع بعض مرتين واحدة الان
+
+52
+00:05:56,350 --> 00:06:01,990
+اذا كنت قاعد اقول له ايه اتش سيكون اتش ايه اف و
+
+53
+00:06:01,990 --> 00:06:09,900
+فقط افلو ضربت الطرفين من جهتي اليمين في الـ A
+
+54
+00:06:09,900 --> 00:06:17,600
+inverse يبقى هذا الكلام بيصير A H A inverse بالشكل
+
+55
+00:06:17,600 --> 00:06:24,720
+اللي عندنا هذا يساوي H A في ال A inverse بالشكل
+
+56
+00:06:24,720 --> 00:06:29,470
+اللي عندنا هذايبقى هذا الكلام if and only if من
+
+57
+00:06:29,470 --> 00:06:33,990
+خاصية ال associativity ممكن اعمل دمج ما بين
+
+58
+00:06:33,990 --> 00:06:41,860
+الاتنين هدول فبصير عندي a h a inverse بده يساويهذا
+
+59
+00:06:41,860 --> 00:06:47,440
+الـ H وخاصية ال associativity يبقى ال A في ال A
+
+60
+00:06:47,440 --> 00:06:52,760
+inverse بالشكل اللي عندنا هنا طب الكلام هذا صحيح
+
+61
+00:06:52,760 --> 00:07:01,200
+if and only if ال A H A inverse A H A inverse بده
+
+62
+00:07:01,200 --> 00:07:02,680
+يساوي تمام
+
+63
+00:07:09,090 --> 00:07:13,510
+يبقى h في الـ identity element تبع الـ group اللي
+
+64
+00:07:13,510 --> 00:07:23,450
+هو g هذا f and only f a h a inverse بده يساوي من
+
+65
+00:07:23,450 --> 00:07:27,110
+itself لأن ال identity element او ضربه في اي
+
+66
+00:07:27,110 --> 00:07:31,930
+element بطلع نفس ال element اللي هو هو المطلوب
+
+67
+00:07:32,700 --> 00:07:38,240
+النقطة الأخيرة اللي هي النقطة الثامنة بتقول ..
+
+68
+00:07:38,240 --> 00:07:46,480
+بتقول ان ال A H is a subgroup من G if and only if
+
+69
+00:07:46,480 --> 00:07:51,980
+ال A belongs to main if and only if ال A belongs
+
+70
+00:07:51,980 --> 00:07:55,360
+لمين ل ال H طيب تمام
+
+71
+00:07:59,780 --> 00:08:03,740
+المرة السابقة قلنا ان الـ left cosets قد تكون
+
+72
+00:08:03,740 --> 00:08:08,100
+subgroup و قد لا تكون subgroup تمام؟ لكن in
+
+73
+00:08:08,100 --> 00:08:12,760
+general ماهياش subgroup هنا بحطلي ال chart ايش
+
+74
+00:08:12,760 --> 00:08:17,340
+اللي يخلي ال left coset subgroupهو ان ضربها في
+
+75
+00:08:17,340 --> 00:08:24,600
+عنصر من عناصر من من عناصر H itself يبقى ال A H
+
+76
+00:08:24,600 --> 00:08:29,140
+عبارة عن subgroup من G إذا كان ال A اللي ضربته هذي
+
+77
+00:08:29,140 --> 00:08:35,760
+من H نفسها وليس وليس من خارجها يبقى الآن بدأجي
+
+78
+00:08:35,760 --> 00:08:44,660
+أقوله assume that افترض ان ال A H is a subgroup من
+
+79
+00:08:44,660 --> 00:08:50,820
+Gبنحاول نثبت ان الـA موجود في الـH وهذا هو الاتجاه
+
+80
+00:08:50,820 --> 00:08:58,440
+الأول طيب تمام السؤال هو هل يا شباب هذه تحتوي على
+
+81
+00:08:58,440 --> 00:09:04,340
+ال identity element؟ ليش؟ لأنها subgroup يبقى باجي
+
+82
+00:09:04,340 --> 00:09:12,640
+بقوله الـE موجودة في الـH since الـH is a subgroup
+
+83
+00:09:12,640 --> 00:09:22,170
+من G تمام؟طيب and ال E موجودة في ال H ولا لا؟ لأن
+
+84
+00:09:22,170 --> 00:09:27,890
+ال H كذلك هي subgroup يبقى ال E موجودة هنا و ال E
+
+85
+00:09:27,890 --> 00:09:35,600
+موجودة هنا طب ال H أليست هي E في H؟يعني صارت هذه
+
+86
+00:09:35,600 --> 00:09:41,480
+left corset وهذه left corset لجهة element موجودة
+
+87
+00:09:41,480 --> 00:09:46,540
+في الإتنين يبقى ال intersection تبعهم لا يمكن أن
+
+88
+00:09:46,540 --> 00:09:58,430
+يساوي في يبقى سا اللي هو E belongs to AH andالـEH
+
+89
+00:09:58,430 --> 00:10:05,450
+هذا معناته ان الـEH لا
+
+90
+00:10:05,450 --> 00:10:13,580
+يمكن ان يساوي فيما دام لا يمكن أن يساوي في معناته
+
+91
+00:10:13,580 --> 00:10:17,680
+اتنين هدول are equal من النقطة ما بعرف كده رقمها
+
+92
+00:10:17,680 --> 00:10:22,200
+خمسة او تلاتة عندنا من اللي ملم المرة الماضية يبقى
+
+93
+00:10:22,200 --> 00:10:29,120
+هذا معناه ان ال a h بده يساوي ال e h يعني ال a h
+
+94
+00:10:29,120 --> 00:10:37,380
+بده يساوي ال h itselfطيب إذا هدول بتساو أليسة ال A
+
+95
+00:10:37,380 --> 00:10:41,900
+موجودة في H النقطة برهنها برضه المرة الماضية ما
+
+96
+00:10:41,900 --> 00:10:47,500
+بعرف اتنين او تلاتة بالكتير مادام ال A H يساوي H
+
+97
+00:10:47,500 --> 00:10:52,780
+هذا معناه ان ال A belongs to H اللي هو الاتجاه
+
+98
+00:10:52,780 --> 00:10:58,060
+الأول بدنا نيجي الاتجاه الثاني فباجي بقوله
+
+99
+00:10:58,060 --> 00:11:00,080
+conversely
+
+100
+00:11:01,310 --> 00:11:09,050
+بالعكس يبقى assume افترض ان ال a belongs to h بدا
+
+101
+00:11:09,050 --> 00:11:14,570
+احاول اثبت ان ال a h is a subgroup مدام ال a
+
+102
+00:11:14,570 --> 00:11:23,350
+belongs to h then ال a h بده يساوي ال h مظبوط؟
+
+103
+00:11:25,320 --> 00:11:30,400
+صح برهنة مدام ال a belongs to h لأن f and only f
+
+104
+00:11:30,400 --> 00:11:34,280
+يعني كانت النقطة عندها بتقول ان ال a h بدي سوى h
+
+105
+00:11:34,280 --> 00:11:38,420
+if and only if ال a belongs to h طب احنا فرضين ال
+
+106
+00:11:38,420 --> 00:11:43,060
+a belongs to h بجه اتنين هدول بيسووا بعض تماما طب
+
+107
+00:11:43,060 --> 00:11:49,000
+هدى subgroup ولا لأ اذا هدى من subgroupهذا بدي
+
+108
+00:11:49,000 --> 00:11:57,220
+يعطينا ان ال a h is a subgroup من g because ال h
+
+109
+00:11:57,220 --> 00:12:05,920
+is a subgroup من gعلى هيك بيكون برهنة النقاط
+
+110
+00:12:05,920 --> 00:12:12,120
+الثماني لهذه اللملة وهي علاقة ال co sets مع بعضها
+
+111
+00:12:12,120 --> 00:12:18,280
+أو مع بعضهم البعض طيب في عندي ملاحظة هنا منحب نشير
+
+112
+00:12:18,280 --> 00:12:26,460
+اليها ال remark بتقول ما يأتيإذا الـ H هي الـ
+
+113
+00:12:26,460 --> 00:12:31,460
+special linear group of two by two matrices over R
+
+114
+00:12:31,460 --> 00:12:35,720
+وهذه الـ subgroup من الـ general linear group of
+
+115
+00:12:35,720 --> 00:12:43,560
+two by two matrices over R فهذه الـ subgroup من
+
+116
+00:12:43,560 --> 00:12:50,910
+الـ general linear group of two by two matricesA
+
+117
+00:12:50,910 --> 00:12:59,170
+and G the coset
+
+118
+00:12:59,170 --> 00:13:13,930
+الهو ال A H is the set of all two
+
+119
+00:13:13,930 --> 00:13:16,590
+by two matrices
+
+120
+00:13:23,780 --> 00:13:30,740
+with the same
+
+121
+00:13:30,740 --> 00:13:35,500
+determinant
+
+122
+00:13:35,500 --> 00:13:42,860
+as a for
+
+123
+00:13:42,860 --> 00:13:48,360
+example كمثال
+
+124
+00:13:48,360 --> 00:13:49,300
+على ذلك
+
+125
+00:13:52,640 --> 00:14:01,220
+المصفوفة اللي تلاتة zero واحد اتنين لو ضربتها فيه
+
+126
+00:14:01,220 --> 00:14:16,280
+H is the set of all two by two matrices with
+
+127
+00:14:16,280 --> 00:14:18,060
+determinant
+
+128
+00:14:25,120 --> 00:14:30,420
+ستة طيب بدنا نسأل السؤال التالي ليش هذا الكلام
+
+129
+00:14:30,420 --> 00:14:38,260
+صحيح طلعلي فيها كويس طلعلي فيها كويس حتى نحاول ان
+
+130
+00:14:38,260 --> 00:14:44,740
+نصل الى الإجابة لهذا السؤال الذي زعمناه ان ال
+
+131
+00:14:44,740 --> 00:14:50,980
+order لها يساوي ستة قلي بلا كده ال remark بتقول ما
+
+132
+00:14:50,980 --> 00:14:55,170
+يأتيلو كانت الـ subgroup هي الـ special linear
+
+133
+00:14:55,170 --> 00:14:59,270
+group ملي جروب اللي هو ال general linear group of
+
+134
+00:14:59,270 --> 00:15:04,470
+two by two matrices over R طبعا هذه كل المصوفات
+
+135
+00:15:04,470 --> 00:15:09,410
+اللي determinant لها لا يساوي zero هذه كل المصوفات
+
+136
+00:15:09,410 --> 00:15:13,670
+اللي determinant لها لا يساوي مين واحد صحيحبقول
+
+137
+00:15:13,670 --> 00:15:19,330
+لأي matrix A في ال group اللي عندنا هذه the coset
+
+138
+00:15:19,330 --> 00:15:26,270
+of H أنا أخدت A من وين؟ من ال general ضربت في من؟
+
+139
+00:15:26,270 --> 00:15:29,730
+في H لل special linear group of two by two
+
+140
+00:15:29,730 --> 00:15:35,770
+matrices overallبقول الـAH هذه كل مصحوفة فيها
+
+141
+00:15:35,770 --> 00:15:41,030
+المحدد تبعها يسوى المحدد تبع المصحوفة ايه بالضبط
+
+142
+00:15:41,030 --> 00:15:48,750
+تماما، ليش؟ لإن هذه المصحوفة كل matrix فيها المحدد
+
+143
+00:15:48,750 --> 00:15:52,830
+دي لها بجداش يبقى لما تجيب ال determinant لأي
+
+144
+00:15:52,830 --> 00:15:57,640
+ألمصير ال determinant لإيه في ال determinantلأ
+
+145
+00:15:57,640 --> 00:16:01,560
+بيهيب واحد يبقى بيظلمين ال determinant ليه بيبقى
+
+146
+00:16:01,560 --> 00:16:05,660
+كل عنصر فيها بدي يكون ال determinant له ك
+
+147
+00:16:05,660 --> 00:16:11,580
+determinant لمين لإيه مثال على ذلكالمصحوفة اللي
+
+148
+00:16:11,580 --> 00:16:15,840
+عندها دي element هذا موجود في ال general linear
+
+149
+00:16:15,840 --> 00:16:22,400
+group لإن المحدد تبعه بقداش بستة يعني لا يساوي
+
+150
+00:16:22,400 --> 00:16:26,520
+زينو معناته موجود في ال general يبقى the set of
+
+151
+00:16:26,520 --> 00:16:30,160
+all two by two matrices اللي هذا مضروبة فيه with
+
+152
+00:16:30,160 --> 00:16:34,380
+determinant ستة السبب لإنه بدي يكون ال determinant
+
+153
+00:16:34,830 --> 00:16:39,990
+لأ ال element هذا مضروب في أي element تاني وليكن
+
+154
+00:16:39,990 --> 00:16:43,770
+بيسوء ال determinant لهذه في ال determinant اللي
+
+155
+00:16:43,770 --> 00:16:46,450
+بيبقى ال determinant اللي بيبقى بواحد صحيح بيبقى
+
+156
+00:16:46,450 --> 00:16:50,550
+ال determinant لهذه بستة في واحد اللي بستة هذه
+
+157
+00:16:50,550 --> 00:16:57,330
+مجرد ملاحظةطيب نجي الآن لنظرية very important في
+
+158
+00:16:57,330 --> 00:17:04,130
+الجبر وهذه أساسية ولا كتاب جبر بيخلوا منها هذه
+
+159
+00:17:04,130 --> 00:17:07,910
+النظرية اسمها لظرية Lagrange Lagrange هو اللي
+
+160
+00:17:07,910 --> 00:17:13,010
+اكتشفها بالبلد هيك ال order لو كانت ال G finite
+
+161
+00:17:13,010 --> 00:17:19,400
+فال order لل sub group بيقسم ال order لل groupوهذه
+
+162
+00:17:19,400 --> 00:17:23,560
+شرطها لكم من أول ما بدأت تقولوا دير بالك قدام
+
+163
+00:17:23,560 --> 00:17:26,960
+هناخد ان ال order لل element بده يقسم ال order لل
+
+164
+00:17:26,960 --> 00:17:30,960
+group و ال order لل sub group بده يقسم ال order لل
+
+165
+00:17:30,960 --> 00:17:36,980
+group كذلك فبدنا نيجي ل Lagrange theorem يبقى هنا
+
+166
+00:17:36,980 --> 00:17:42,060
+Lagrange theorem
+
+167
+00:17:44,840 --> 00:17:52,660
+النظرية هذه بتقول ما ياتي if ال H is
+
+168
+00:17:52,660 --> 00:18:07,120
+a subgroup of a finite group G then
+
+169
+00:18:07,120 --> 00:18:13,560
+ال order ل H divides
+
+170
+00:18:15,730 --> 00:18:25,210
+الـ order لـ G وزيادة على ذلك moreover و أكثر من
+
+171
+00:18:25,210 --> 00:18:35,810
+ذلك the number of this connect the number of
+
+172
+00:18:35,810 --> 00:18:43,010
+this connect the number of this connect left أو
+
+173
+00:18:43,010 --> 00:18:50,370
+right leftاو رايت هدى والله هدى الاتنين are the
+
+174
+00:18:50,370 --> 00:19:03,570
+same left او right cassettes of H in G is ال order
+
+175
+00:19:03,570 --> 00:19:11,110
+ل G على ال order ال main لل H بنبرهن
+
+176
+00:19:11,110 --> 00:19:13,510
+صحة هذا الكلام ال approve
+
+177
+00:19:29,970 --> 00:19:35,150
+خلّي بالا كدا الان H sub group من مين؟ من finite
+
+178
+00:19:35,150 --> 00:19:44,050
+group Gو ال H هي ال sub group من ل group G بدي
+
+179
+00:19:44,050 --> 00:19:49,370
+اثبت ان ال order ل G بيقسم ال order ال order ل H
+
+180
+00:19:49,370 --> 00:19:55,210
+بيقسم ال order ل G يعني عدد العناصر في H يقسم عدد
+
+181
+00:19:55,210 --> 00:20:01,370
+العناصر في من في Gوزيادة على ذلك عدد ال left او
+
+182
+00:20:01,370 --> 00:20:07,310
+right destined cosets في H and G بيسوي ال order لل
+
+183
+00:20:07,310 --> 00:20:13,330
+H على ال order لمين لل G هذا اللي عايزين نتبته في
+
+184
+00:20:13,330 --> 00:20:14,650
+العدد
+
+185
+00:20:19,350 --> 00:20:24,070
+الـ order اللى جى على ال order لل H بيعطينى عدد ال
+
+186
+00:20:24,070 --> 00:20:27,210
+left cosets وهنا كاتبين ال order اللى جى على ال
+
+187
+00:20:27,210 --> 00:20:31,810
+order اللى H تمام طب خلّينى نثبت النقطة الأولى
+
+188
+00:20:31,810 --> 00:20:37,710
+بيقولى هنا عدد ال left .. destined left cosets او
+
+189
+00:20:37,710 --> 00:20:41,970
+right cosets اذا انا بدى اروح اجيب كل ال left
+
+190
+00:20:41,970 --> 00:20:47,250
+cosets اللى موجودات على اللى هو ال sub group من ال
+
+191
+00:20:47,250 --> 00:20:50,460
+group اللى عندنالما أخدنا الأمثلة المرة اللى فاتت
+
+192
+00:20:50,460 --> 00:20:56,520
+لجينا انه أحيانا ال lift corsets بتساوي مظبوط يبقى
+
+193
+00:20:56,520 --> 00:21:00,220
+انا بدي أجيب كل ال lift corsets اللى بيكون ولا
+
+194
+00:21:00,220 --> 00:21:05,300
+واحدة فيهم بتساوي ات تانية يبقى بدي أجي أقوله let
+
+195
+00:21:05,300 --> 00:21:15,620
+a1h a2h ونظل ماشيين the arh ب the
+
+196
+00:21:18,560 --> 00:21:24,940
+Left Destinate Cosets
+
+197
+00:21:24,940 --> 00:21:28,780
+of
+
+198
+00:21:28,780 --> 00:21:38,760
+H and G بدأ افترض ان هذا عبارة عن ايش؟ عبارة عن كل
+
+199
+00:21:38,760 --> 00:21:42,720
+Destinate Left Cosets اللي ولا واحدة بتساوي
+
+200
+00:21:42,720 --> 00:21:53,010
+التانيةطيب، الآن بداجي أقول let ال A belongs to G
+
+201
+00:21:53,010 --> 00:22:06,300
+then ال A H is a left cassetteصحيح ولا لأ يعني
+
+202
+00:22:06,300 --> 00:22:11,740
+معناته ان ال a h هساوي واحدة من هدول هتكون واحدة
+
+203
+00:22:11,740 --> 00:22:23,580
+منهم صح يبقى الآن ساعة ال a h هذه بدها ساوي a i h
+
+204
+00:22:23,580 --> 00:22:27,420
+تمام
+
+205
+00:22:27,420 --> 00:22:39,760
+طيب كويس butwe know that احنا بنعرف ان ال a موجودة
+
+206
+00:22:39,760 --> 00:22:45,800
+في ال a h فموجودة في ال a h مظبوط
+
+207
+00:22:47,230 --> 00:22:51,190
+بارهنها المرة اللى فاتت مدام موجودة هنا وهذه
+
+208
+00:22:51,190 --> 00:22:55,490
+بتساوي هذه يبقى ال element وين موجود؟ في ال A I H
+
+209
+00:22:55,490 --> 00:23:05,750
+يبقى هذا بده يعطينا ان ال A belongs to A I H طب
+
+210
+00:23:05,750 --> 00:23:09,830
+انا لما أخدت ال A في G أخدت عنصر عشوائي ولا عنصر
+
+211
+00:23:09,830 --> 00:23:16,430
+محددعشوائي مدام عشوائي ينطبق على أي عنصر موجود في
+
+212
+00:23:16,430 --> 00:23:23,210
+ال group G بفهم من هذا الكلام انه كل عنصر موجود في
+
+213
+00:23:23,210 --> 00:23:28,910
+جي حالة جي في واحدة من ال lift cassettes صح ولا لأ
+
+214
+00:23:28,910 --> 00:23:35,440
+سكت الشعبمرة تانية انا اخدت a عشوائيا من g تمام
+
+215
+00:23:35,440 --> 00:23:40,820
+لجيت ال a هذا موجود في واحدة من هدول ايه موجود في
+
+216
+00:23:40,820 --> 00:23:48,340
+ال aiH مظبوط ممتاز جدا يبقى هذا يعني انه كل عنصر
+
+217
+00:23:48,340 --> 00:23:52,740
+بتاخده من G لازم تلاقيه في main في واحدة من ال
+
+218
+00:23:52,740 --> 00:23:58,120
+left distant cosets مظبوط يبقى this means that
+
+219
+00:23:58,120 --> 00:24:06,280
+this means that any element
+
+220
+00:24:09,860 --> 00:24:17,240
+in G belongs to
+
+221
+00:24:17,240 --> 00:24:24,440
+one coset of
+
+222
+00:24:24,440 --> 00:24:32,280
+A1H A2H و لغاية ARH
+
+223
+00:24:35,230 --> 00:24:42,990
+أذا كل عنصر باخده من جيه لما أخده من جيه بلاقيه في
+
+224
+00:24:42,990 --> 00:24:48,390
+واحدة من هدول طب السؤال هو هل هدول بيسووا بعضهم
+
+225
+00:24:48,390 --> 00:24:54,110
+يبقى ال intersection five ممتاز جدا و لو واحدة جال
+
+226
+00:24:54,110 --> 00:24:57,230
+بيسوى تاني نجال عليهم this and that يبقى ال
+
+227
+00:24:57,230 --> 00:25:01,990
+intersection تبعهم يسوى five إذا لا يمكن لعنصر
+
+228
+00:25:01,990 --> 00:25:09,190
+يكون confidentين منهمصح ولا لا يبقى هنا بقول هنا
+
+229
+00:25:09,190 --> 00:25:22,110
+but ولكن اللي هو ال aih لا يساوي ال ajh for اللي
+
+230
+00:25:22,110 --> 00:25:29,290
+هو ال I لا يساوي ال jلما هؤلاء ما يتساووش يبقى
+
+231
+00:25:29,290 --> 00:25:33,530
+هؤلاء ما يتساووش بعض إذا الـI والـJ لا يتساووش بعض
+
+232
+00:25:33,530 --> 00:25:40,090
+إذا كل element موجود بالضبط في واحدة من من هؤلاء
+
+233
+00:25:40,090 --> 00:25:45,350
+طيب إذا الـG مش هي عبارة عن ال union تبع هؤلاء
+
+234
+00:25:45,350 --> 00:25:47,170
+كلهم ولا لأ؟
+
+235
+00:25:56,620 --> 00:26:08,300
+لجروب G هي عبارة عن A1H اتحاد A2H اتحاد اتحاد ARH
+
+236
+00:26:08,300 --> 00:26:18,180
+كويس يعني هذا يعني ان ال order ل G ال order ل G
+
+237
+00:26:18,180 --> 00:26:26,120
+بدي سوى ال order ل A1H زائد ال order ل A2H
+
+238
+00:26:28,500 --> 00:26:39,220
+زائد زائد زائد ال order لل ARH طيب
+
+239
+00:26:39,220 --> 00:26:45,760
+سؤال انا H فيها عشرة elements مثلاو جيت ضربت ال H
+
+240
+00:26:45,760 --> 00:26:51,380
+في أي عنصر من عناصر G بيطلع عندى عشرة elements ولا
+
+241
+00:26:51,380 --> 00:26:55,920
+أكتر ولا أقل عشرة بالضبط لما يكون عندى ال sub
+
+242
+00:26:55,920 --> 00:27:00,120
+group و اضربها في أي element من ال group بيضلوا
+
+243
+00:27:00,120 --> 00:27:04,460
+العشرة العددهم عشرة صحيح بيختلفوا لكن بيضلوا عشرة
+
+244
+00:27:04,460 --> 00:27:09,780
+من ناحية العدد معناته ال order لل a1h يساوي ال
+
+245
+00:27:09,780 --> 00:27:15,730
+order للhو ال order ل A to H هو ال order ل H و ال
+
+246
+00:27:15,730 --> 00:27:22,130
+order ل A RH هو ال order ل H يعني هذا الكلام يعني
+
+247
+00:27:22,130 --> 00:27:28,770
+ان ال order ل G بده يساوي ال order ل H زائد ال
+
+248
+00:27:28,770 --> 00:27:36,690
+order ل H زائد زائد ال order ل H اكم مرة هدول؟ R
+
+249
+00:27:37,380 --> 00:27:46,440
+لأن عددهم R يبقى هذا الكلام معناته R times يبقى R
+
+250
+00:27:46,440 --> 00:27:52,500
+من المرات يبقى أصبح الأن ال order اللي جيه بده
+
+251
+00:27:52,500 --> 00:27:58,900
+يساوي ال R في ال order ال H لأن عددهم Rطب ايش
+
+252
+00:27:58,900 --> 00:28:06,300
+تفسيرك لهذه ان ال order لل H بيقسم ال order ل G
+
+253
+00:28:06,300 --> 00:28:15,420
+هذا معناه ان ال order ل H divides ال order ل G
+
+254
+00:28:15,420 --> 00:28:23,410
+وبالتالي انت هنامن نظرية Lagrange راح قلي واكثر من
+
+255
+00:28:23,410 --> 00:28:27,050
+ذلك the number of distinct left cosets او right
+
+256
+00:28:27,050 --> 00:28:31,570
+cosets of H and G يساوي ال order لل G على ال order
+
+257
+00:28:31,570 --> 00:28:41,810
+لمين لل H باجي بقوله هنا اكم
+
+258
+00:28:41,810 --> 00:28:52,620
+واحدة left cosets عندنا هناare يبقى هنا the number
+
+259
+00:28:52,620 --> 00:29:05,780
+of left أو حتى right cassettes of each the number
+
+260
+00:29:05,780 --> 00:29:07,460
+of destined
+
+261
+00:29:11,540 --> 00:29:19,860
+Left or Right Cosets of H in G is R طب ال R قد
+
+262
+00:29:19,860 --> 00:29:28,080
+يساوي هنا مش هو ال order ل G على ال order لل H
+
+263
+00:29:28,080 --> 00:29:38,160
+يبقى ال order ل G على ال order لل H طب كويس شوفوا
+
+264
+00:29:38,160 --> 00:29:46,030
+شوفوابعد هذا البرهان عندي تعريف متعلق بالنتيجة
+
+265
+00:29:46,030 --> 00:29:50,550
+اللى توصلنا إليها من نظرية لاجرانج التعريف هذا
+
+266
+00:29:50,550 --> 00:30:00,170
+بيقول ما يأتي the number of left the number of
+
+267
+00:30:00,170 --> 00:30:12,050
+distinct left أو rightهذا او هذا left dissonant
+
+268
+00:30:12,050 --> 00:30:21,410
+right او left cosets of HNG
+
+269
+00:30:21,410 --> 00:30:32,370
+of HNG is called هذا بنسميه ال index is called the
+
+270
+00:30:32,370 --> 00:30:38,490
+index of
+
+271
+00:30:41,030 --> 00:30:47,870
+a subgroup a subgroup
+
+272
+00:30:47,870 --> 00:30:54,070
+H in G and
+
+273
+00:30:54,070 --> 00:31:05,130
+denoted by وبنعطيله الرمز التالي الـ G مقطعتين فوق
+
+274
+00:31:05,130 --> 00:31:09,090
+بعض وH بالشكل اللي عندنا هذا
+
+275
+00:31:14,520 --> 00:31:18,480
+طيب هذا بيقولي عدد الـdestinate left او right
+
+276
+00:31:18,480 --> 00:31:23,880
+cosets of H and G بسميه ال index تبع ال subgroup H
+
+277
+00:31:23,880 --> 00:31:30,220
+في من في ال group G طب قداش عددهم هدول؟ R يبقى
+
+278
+00:31:30,220 --> 00:31:35,400
+احنا عندنا ملاحظة بسيطة جدا من ال grand theorem
+
+279
+00:31:35,400 --> 00:31:42,190
+قلنا ال order ل G بدي سوى ال R في ال order ل Hصح
+
+280
+00:31:42,190 --> 00:31:48,330
+ولا لا؟ إذا بقدر أكتب نظرية Lagrange بطريقة أخرى
+
+281
+00:31:48,330 --> 00:31:53,110
+إن ال order ل G بده يساوي ال R هو عدد ال left
+
+282
+00:31:53,110 --> 00:31:59,050
+coset اللي أعطيته الرمز ال index تبع ال H in G في
+
+283
+00:31:59,050 --> 00:32:06,870
+ال order ل Hيبقى بصيغة نتيجة نظرية لاجرانج بالصيغة
+
+284
+00:32:06,870 --> 00:32:11,050
+اللى عندنا اللى توصلنا لها هذه ان ال order ل G بده
+
+285
+00:32:11,050 --> 00:32:15,590
+يسوي R في ال order ل H يا بقول ال order ل G بده
+
+286
+00:32:15,590 --> 00:32:19,890
+يسوي ال index تبع ال subgroup H في ال group G
+
+287
+00:32:19,890 --> 00:32:26,210
+مضروب في ال order تبع من تبع ال H الشكل اللى عندنا
+
+288
+00:32:26,210 --> 00:32:34,150
+هذا تمام بدنا نبدأ نعطي أمثلة على ذلكأول مثال
+
+289
+00:32:34,150 --> 00:32:46,610
+example بقول let ال G تساوي S4 and
+
+290
+00:32:48,180 --> 00:32:54,280
+الـ H هي الـ sub group generated by ال permutation
+
+291
+00:32:54,280 --> 00:33:00,660
+واحد اتنين تلاتة اربعة اتنين تلاتة اربعة واحد
+
+292
+00:33:00,660 --> 00:33:03,720
+بالشكل اللي عندنا هنا find
+
+293
+00:33:26,290 --> 00:33:27,690
+S4S4S4S4S4S4S4S4S4S4
+
+294
+00:33:38,910 --> 00:33:44,450
+سؤال مرة تانية السؤال بيقول احنا عندنا GS4 اللى
+
+295
+00:33:44,450 --> 00:33:50,650
+فيها اربعة وعشرين عنصر اخدنا منها subgroup H مين
+
+296
+00:33:50,650 --> 00:33:54,650
+هي ال subgroup هذا ال subgroup اللى تتولد بال
+
+297
+00:33:54,650 --> 00:34:00,390
+permutation اللى عندنا جداش ال index تبع ال H in
+
+298
+00:34:00,390 --> 00:34:01,430
+S4
+
+299
+00:34:05,930 --> 00:34:09,950
+الاندكس يساوي ال order لل group على ال order لل
+
+300
+00:34:09,950 --> 00:34:13,690
+subgroup ال order تبع ال group يعرفينه 24 لكن ال
+
+301
+00:34:13,690 --> 00:34:18,460
+order تبع ال subgroup مش عارفهمش عارفه لكن لازم
+
+302
+00:34:18,460 --> 00:34:23,280
+تعرفه إذا بدي أبدأ أضرب هذه في نفسي مرة ما طلعش ال
+
+303
+00:34:23,280 --> 00:34:27,780
+identity كمان مرة ما طلعش لغاية ما يطلع من ال
+
+304
+00:34:27,780 --> 00:34:32,020
+identity وبالتالي بيكون الأس اللي عندي هو من ال
+
+305
+00:34:32,020 --> 00:34:37,430
+order تبع ال group هذه وجهة نظر قديمةهو ايش وجهة
+
+306
+00:34:37,430 --> 00:34:43,230
+النظر الجديدة ان انت هذى اجيب لل order تبعها بكل
+
+307
+00:34:43,230 --> 00:34:50,570
+بساطة بكل بساطة كده بقوله انا هذا let alpha تساوي
+
+308
+00:34:50,570 --> 00:34:55,390
+ال permutation واحد اتنين تلاتة اربعة اتنين تلاتة
+
+309
+00:34:55,390 --> 00:35:04,550
+اربعة واحد thenالألف تساوي بقدر اكتبها على ال
+
+310
+00:35:04,550 --> 00:35:09,210
+cycle form اما ال cycle واحدة او product of two
+
+311
+00:35:09,210 --> 00:35:14,270
+cycles حسب اللي موجود عندى تمام اذا باجي بقوله بدي
+
+312
+00:35:14,270 --> 00:35:17,390
+اكتب على شكل cycle الواحد مين صوبته يا شباب
+
+313
+00:35:17,390 --> 00:35:25,230
+والاتنين والتلاتة والاربعة قفلت اذا بقدر اجيب ال
+
+314
+00:35:25,230 --> 00:35:31,250
+order لالف ولا ليبقى هذا بيعطينا ان ال order ل
+
+315
+00:35:31,250 --> 00:35:35,990
+alpha بده يساوي طول ال cycle اللي عندنا هو قداش
+
+316
+00:35:35,990 --> 00:35:41,530
+أربعة يبقى ال order ل alpha بده يساوي أربعة طيب
+
+317
+00:35:41,530 --> 00:35:46,040
+لما يكون عندنا ال cycle ك groomشو العلاقة بين
+
+318
+00:35:46,040 --> 00:35:50,740
+order لل group و order لل generator؟ اتنين نفس
+
+319
+00:35:50,740 --> 00:35:56,040
+الشيء يعني معنى هذا الكلام ان ال order لل H ساوى
+
+320
+00:35:56,040 --> 00:36:01,220
+ال order ل alpha وهذا بدي يعطيني من؟ بدي يعطيني
+
+321
+00:36:01,220 --> 00:36:07,280
+اللي هو النتيجة اللي هو أربعةهذا سيعطيني ان ال
+
+322
+00:36:07,280 --> 00:36:16,060
+order ل H هو order ل alpha اربعة ليش؟ لان H هى
+
+323
+00:36:16,060 --> 00:36:20,720
+الـcyclic subgroup generated by ال permutation
+
+324
+00:36:20,720 --> 00:36:24,100
+alpha اللى عندنا يبقى اثار ال order ل alpha هو
+
+325
+00:36:24,100 --> 00:36:29,790
+order ل Hما دام هيكي بقى صارت قصتنا بسيطة قال لي
+
+326
+00:36:29,790 --> 00:36:36,210
+هاتلي ال index بقوله الآن ال index ل ال subgroup H
+
+327
+00:36:36,210 --> 00:36:43,450
+في ال group S4 يساوي ال order لل S4 على ال order
+
+328
+00:36:43,450 --> 00:36:49,530
+لل H ال order لل S4 اللي هو أربعة factorial وهذه
+
+329
+00:36:49,530 --> 00:36:58,980
+أربعةيبقى هذه بنقول أربعة في تلاتة factorial على
+
+330
+00:36:58,980 --> 00:37:04,460
+أربعة يبقى تلاتة factorial تلاتة factorial يسوى
+
+331
+00:37:04,460 --> 00:37:09,860
+كده؟ يسوى ستةإذاً ال index تبع ال subgroup اللي
+
+332
+00:37:09,860 --> 00:37:15,920
+عندنا هذه في ال group G الأصلية هو عبارة عن ستة،
+
+333
+00:37:15,920 --> 00:37:21,520
+إيش يعني ستة؟ يعني أنا ضمنت عدد ال left destined
+
+334
+00:37:21,520 --> 00:37:28,080
+cosets لل S4 لما نضربهم في ال .. لما ينضربوا في ال
+
+335
+00:37:28,080 --> 00:37:31,140
+permutation اللي في ال .. في ال H اللي عند ال
+
+336
+00:37:31,140 --> 00:37:36,870
+subgroup بطلع عندى بس ستة left destined cosetsيعني
+
+337
+00:37:36,870 --> 00:37:42,830
+معناه كل أربعة هيتساووا عشان يطلع عندى ستة صح ولا
+
+338
+00:37:42,830 --> 00:37:47,950
+لا يعني كل أربعة left cosets هيطلعوا نفس الشيء
+
+339
+00:37:47,950 --> 00:37:52,530
+وبالتالي ضمنت عدد ال left cosets يساوي ستة كان
+
+340
+00:37:52,530 --> 00:37:56,810
+بيمكني أصيغ نفس السؤال و بدل ما اقول هاتل ال index
+
+341
+00:37:56,810 --> 00:38:02,950
+اقول find the number of left cosets of H in S4
+
+342
+00:38:02,950 --> 00:38:07,970
+واسكتمش هو نفس السؤال نفس السؤال حرفية لكن قعدت
+
+343
+00:38:07,970 --> 00:38:20,270
+صيغته بطريقة اخرى نعطي مثال اخر كمان example ال
+
+344
+00:38:20,270 --> 00:38:26,370
+example يا شباب هذا سؤال 14 من الكتاب بقول suppose
+
+345
+00:38:26,370 --> 00:38:27,030
+that
+
+346
+00:38:30,100 --> 00:38:40,900
+suppose that افترض ان الـ K is a proper subgroup
+
+347
+00:38:40,900 --> 00:38:44,540
+of
+
+348
+00:38:44,540 --> 00:38:48,720
+H and
+
+349
+00:38:48,720 --> 00:38:56,380
+الـ H is a proper subgroup
+
+350
+00:38:59,010 --> 00:39:04,150
+of G if
+
+351
+00:39:04,150 --> 00:39:18,050
+ال order لل K هو اتنين واربعين and ال order لل G
+
+352
+00:39:18,050 --> 00:39:23,150
+هو اربع مية وعشرين what
+
+353
+00:39:24,410 --> 00:39:35,730
+are the possible orders of
+
+354
+00:39:35,730 --> 00:39:37,190
+H
+
+355
+00:40:06,270 --> 00:40:10,790
+مرة تانية انا عندي K proper subgroup من H ايش يعني
+
+356
+00:40:10,790 --> 00:40:15,890
+proper subgroup؟ لأ تساوي H subset منها لكن لا
+
+357
+00:40:15,890 --> 00:40:21,350
+تساويها وعندي في نفس الوقت ال H proper subgroup من
+
+358
+00:40:21,350 --> 00:40:26,850
+G يعني K subgroup من H و ال H subgroup من G وكل
+
+359
+00:40:26,850 --> 00:40:31,110
+واحدة فيهم عبارة عن ال proper يعني لا تساوي الجروب
+
+360
+00:40:31,110 --> 00:40:35,940
+التانيقال لو كان ال order ل K الأولى هو اتنين
+
+361
+00:40:35,940 --> 00:40:40,500
+واربعين وال order ل الأخرى أربع مائة وعشرين ما هي
+
+362
+00:40:40,500 --> 00:40:47,100
+الاحتمالات الممكنة لل order تبع ال H فنقوله ماشي
+
+363
+00:40:47,100 --> 00:40:49,160
+يبقى هنا solution
+
+364
+00:40:54,430 --> 00:41:02,450
+الآن نحن لدينا K subgroup يبقى K subgroup من H هذا
+
+365
+00:41:02,450 --> 00:41:12,730
+معناته ان ال order لل K بيقسم ال order لل H مظبوط؟
+
+366
+00:41:12,730 --> 00:41:19,150
+طب ال order لل H كده انا مش عارف يبقى هنا كده
+
+367
+00:41:21,550 --> 00:41:27,510
+K subgroup من H هي K proper subgroup من H K
+
+368
+00:41:27,510 --> 00:41:31,830
+subgroup من H يبقى ال order ل K بده يقسم ال order
+
+369
+00:41:31,830 --> 00:41:38,370
+ل H يبقى بداجي اقوله هنا assume افترض ان ال order
+
+370
+00:41:38,370 --> 00:41:47,080
+ل H بده يساوي ال M مثلا يبقى بناء عليهالـ order لـ
+
+371
+00:41:47,080 --> 00:41:55,440
+K ميعطيني ياله جداش 42 تقسم من ال M يعني معناته
+
+372
+00:41:55,440 --> 00:42:06,600
+هذا ال M تساوي مضعفات 42 يساوي هذا S مثلا في فيل
+
+373
+00:42:06,600 --> 00:42:13,080
+42 و هنا for some
+
+374
+00:42:25,520 --> 00:42:31,280
+يبقى كتابة الـ M مجهولة على شكل رقم مضروب جداش
+
+375
+00:42:31,280 --> 00:42:40,090
+اتنين او اربعينالان انا عندي كذلك ال order ل ال H
+
+376
+00:42:40,090 --> 00:42:46,930
+او ال H هذه ال sub group من G sub group من G هذا
+
+377
+00:42:46,930 --> 00:42:53,390
+معناته ان ال order ل ال H divide ال order ل G طبقا
+
+378
+00:42:53,390 --> 00:43:00,760
+لنظرية Lagrange مدام هيك هذا معناهإن ال order للـ
+
+379
+00:43:00,760 --> 00:43:09,980
+G هنا بدي ساوي ال R في ال order لـ H مثلايبقى هذا
+
+380
+00:43:09,980 --> 00:43:15,340
+معناه ان ال order اللي جيه ليه أربعمية وعشرين
+
+381
+00:43:15,340 --> 00:43:22,540
+تساوي R في مين في ال M لأن انا فرض ال order ال H
+
+382
+00:43:22,540 --> 00:43:27,440
+يساوي مدى كده؟ يساوي M اطلعلي في المعادلة اللي
+
+383
+00:43:27,440 --> 00:43:33,640
+عندنا هذه واطلعلي في المعادلة اللي عندنا هذه اذا
+
+384
+00:43:33,640 --> 00:43:40,320
+انا بقدر اخلق من المعادلتين معادلةما هي هذه
+
+385
+00:43:40,320 --> 00:43:48,720
+المعادلة؟ اللي هي أربعمية وعشرين بده يساوي RS في
+
+386
+00:43:48,720 --> 00:43:54,940
+من؟ في اتنين واربعين يعني شيلت ال M اللي عندنا هذه
+
+387
+00:43:54,940 --> 00:44:00,240
+ويرحلت شيلت ال M اللي عندنا هذه وكتبت بدلها S في
+
+388
+00:44:00,240 --> 00:44:07,430
+اتنين واربعينتمام طيب في قسم ما بين الطرفين اه
+
+389
+00:44:07,430 --> 00:44:12,430
+يبقى لو جسمت كله على اتنين واربعين هذا بدي يعطيني
+
+390
+00:44:12,430 --> 00:44:20,590
+R S تساوي عشرة مدام عشرة احتمال ال R بواحد وال S
+
+391
+00:44:20,590 --> 00:44:31,920
+بعشرةاحتمال ان S بواحد وR بعشرة احتمال R بخمسة وS
+
+392
+00:44:31,920 --> 00:44:36,280
+باتنين احتمال R باتنين وS بخمسة هي الاحتمالات
+
+393
+00:44:36,280 --> 00:44:48,040
+الأربعة في غيرهم؟ لأ يبقى هنا so we have four
+
+394
+00:44:48,040 --> 00:44:50,280
+possibilities four
+
+395
+00:44:57,390 --> 00:45:05,110
+أربعة احتمالات الاحتمال الأول ان الار تساوي واحد
+
+396
+00:45:05,110 --> 00:45:12,510
+والاس تساوي عشرةهل هذا الكلام ممكن؟ والله مش ممكن
+
+397
+00:45:12,510 --> 00:45:20,310
+الحين لو ال S وتعشرة يبقى ال M كده؟ 420 ممكن هذا
+
+398
+00:45:20,310 --> 00:45:27,730
+الكلام؟ يتناقض مع كلمة proper تمام يبقى هذا this
+
+399
+00:45:27,730 --> 00:45:31,310
+is impossible
+
+400
+00:45:33,850 --> 00:45:43,190
+هذا غير ممكن السبب because ان ال H is proper
+
+401
+00:45:43,190 --> 00:45:49,210
+subgroup من G لان على الجهة ده مش ممكن ممكن العكس
+
+402
+00:45:49,210 --> 00:45:57,130
+نقطة ثانية ان ال R تساوي عشرة و ال S تساوي واحد
+
+403
+00:45:58,440 --> 00:46:04,560
+تمام؟ طب بدنا نأتي إلى ال S تساوي واحد لو ال S سوى
+
+404
+00:46:04,560 --> 00:46:12,060
+واحد يبقى ال M قداش؟ يعني قد مين؟ قد K ال H صارت
+
+405
+00:46:12,060 --> 00:46:16,760
+قد K مظبوط و هذا كلام غلط لأن احنا نقولين K proper
+
+406
+00:46:16,760 --> 00:46:24,020
+يبقى برضه هذا this is impossible because capital K
+
+407
+00:46:24,020 --> 00:46:25,680
+is proper
+
+408
+00:46:28,120 --> 00:46:33,920
+يبقى هذا لا يمكن يحصل بالمرة طب نجي النقطة التالتة
+
+409
+00:46:33,920 --> 00:46:40,460
+النقطة التالتة ممكن ال R يساوي اتنين وال S يساوي
+
+410
+00:46:40,460 --> 00:46:48,020
+خمسةطيب لو حطيت ال S هنا بخمسة بصير هدول كده؟ 210
+
+411
+00:46:48,020 --> 00:46:55,520
+ممكن؟ اه ممكن مافيش مشكلة يبقى هنا ال R سواء S
+
+412
+00:46:55,520 --> 00:47:03,540
+then ال M بدها تساوي ال S لخمسة في اتنين واربعين
+
+413
+00:47:03,540 --> 00:47:08,540
+واللي هو بده يساوي متين وعشر خمسة في اتنين بعشر
+
+414
+00:47:08,540 --> 00:47:13,880
+وخمسة في اربع باشرين واحد واحدهو عشرين تمام هذا لو
+
+415
+00:47:13,880 --> 00:47:21,260
+كانت ال S بخمسة وال R باتنين الاحتمال الرابع ان ال
+
+416
+00:47:21,260 --> 00:47:30,930
+R تساوي خمسة وال S يساوي اتنينال M يساوي ال M
+
+417
+00:47:30,930 --> 00:47:37,050
+يساوي S في اتنين واربعين ال S عندي باتنين في اتنين
+
+418
+00:47:37,050 --> 00:47:42,830
+واربعين ويساوي قداش اربعة و تمانين ممكن ولا مش
+
+419
+00:47:42,830 --> 00:47:49,570
+ممكن برضه ممكن يبقى باجي هنا بقوله the possible
+
+420
+00:47:49,570 --> 00:47:52,290
+orders
+
+421
+00:47:54,230 --> 00:48:06,190
+of H are أربعة وتمانين or متين وعشرة يبقى كله
+
+422
+00:48:06,190 --> 00:48:11,170
+اعتمدنا فيه على مين على Lagrange theorem الان
+
+423
+00:48:11,170 --> 00:48:16,170
+وصلنا لنتائج على نظرية Lagrange حصلنا حوالي أربع
+
+424
+00:48:16,170 --> 00:48:21,830
+نتائج و بكلهم بيفيدونا كتير في حل المسائل المرة
+
+425
+00:48:21,830 --> 00:48:23,330
+القادمة ان شاء الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/0kvBKFtUQDQ_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/0kvBKFtUQDQ_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..4e0ce3570535a553955d9fd4ea19f1f3faec6678
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/0kvBKFtUQDQ_raw.json
@@ -0,0 +1 @@
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\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/0kvBKFtUQDQ_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/0kvBKFtUQDQ_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..21cb438e659c0a94d4085b7f47d768b08d96195d
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/0kvBKFtUQDQ_raw.srt
@@ -0,0 +1,2448 @@
+1
+00:00:20,990 --> 00:00:24,030
+بسم الله الرحمن الرحيم اليوم هتتكلم عن ال viral
+
+2
+00:00:24,030 --> 00:00:28,990
+vaccines و ال viral vaccines موضوع مهم لإنه بدنا
+
+3
+00:00:28,990 --> 00:00:33,450
+نفهم شغل كتير مهمة ان ال viral infection تختلف عن
+
+4
+00:00:33,450 --> 00:00:36,150
+ال bacterial infection احنا ال bacterial infection
+
+5
+00:00:36,150 --> 00:00:40,330
+كتير نتعامل معها بال antimicrobials او ال
+
+6
+00:00:40,330 --> 00:00:44,590
+antibiotics لكن يا أهل ترى ال antivirals بنفس
+
+7
+00:00:44,590 --> 00:00:48,270
+كفاءة ال antibiotics و ال antimicrobials بالتأكيد
+
+8
+00:00:48,270 --> 00:00:55,090
+لأ وبالتالي لابدمن التفكير بيمنع حدوث ال viral
+
+9
+00:00:55,090 --> 00:01:01,410
+infection أكتر من فكر بعملية معالجة هذه الأمرض فال
+
+10
+00:01:01,410 --> 00:01:08,390
+viral vaccines وفّرت لنا مجموعة من الميزات بيناعرف
+
+11
+00:01:08,390 --> 00:01:11,930
+أن ال prevention لل viral disease بتركز على شغلتين
+
+12
+00:01:11,930 --> 00:01:17,210
+vaccines that induce active immunityعشان انا لما
+
+13
+00:01:17,210 --> 00:01:22,470
+الشخص يتعرض للفيروس يكون عنده ذاكره و عنده مناعة
+
+14
+00:01:22,470 --> 00:01:26,710
+ضد هذا الفيروس لازم اوفرله active immunization او
+
+15
+00:01:26,710 --> 00:01:32,270
+بعض الأحيان بنضطر نلجأ الى اعطاء المريض antibodies
+
+16
+00:01:32,270 --> 00:01:38,010
+مجهزة في خارج الجسم هذه بنسميها active immunity
+
+17
+00:01:38,010 --> 00:01:42,150
+وهذه بنسميها passive immunityالـ Active Immunity
+
+18
+00:01:42,150 --> 00:01:46,330
+نظرا لان احنا بنعتمد على ان جهاز المناع هو اللذي
+
+19
+00:01:46,330 --> 00:01:51,630
+سيقوم بالمهمة بينما ال passive immunity احنا
+
+20
+00:01:51,630 --> 00:01:54,710
+معتمدين على ال antibodies اللي وفرناها ان تجوم
+
+21
+00:01:54,710 --> 00:02:01,510
+بهذه المهمة ال active immunity بنقدر نقول ان فيانا
+
+22
+00:02:01,510 --> 00:02:07,470
+two types of vaccinesواحد بيشمل اللي هو ال live
+
+23
+00:02:07,470 --> 00:02:11,450
+virus والتاني بيشمل ال killed virus ويمكن معظم
+
+24
+00:02:11,450 --> 00:02:17,910
+حوارنا هيتمحور اليوم على الفرقات بين ال live و ال
+
+25
+00:02:17,910 --> 00:02:21,650
+killed vaccines طبعا هناك أنواع أخرى يعني أقل
+
+26
+00:02:21,650 --> 00:02:25,790
+أهمية أو خلينا نقول أقل انتشارا ولكنها قد تكون هي
+
+27
+00:02:25,790 --> 00:02:30,470
+الأهم بعد ذلك في المستقبلاللي بسميها احنا subunit
+
+28
+00:02:30,470 --> 00:02:37,550
+vaccines واللي بتحتوي على purified منقة يعني لا
+
+29
+00:02:37,550 --> 00:02:41,270
+تحتوي على الفيروس كاملا لا live ولا killed تحتوي
+
+30
+00:02:41,270 --> 00:02:46,090
+على جزيئات او اي جزاء من البروتينات اللي موجودة في
+
+31
+00:02:46,090 --> 00:02:54,530
+هذا الفيروس لو دي نتكلم عن الفرقات بينال .. ال ..
+
+32
+00:02:54,530 --> 00:02:57,130
+ال .. ال subunit vaccine عفوا يعني ال live و ال
+
+33
+00:02:57,130 --> 00:03:01,450
+killed طب كيف بنقارنهم بمين بال subunit؟ غالبا ال
+
+34
+00:03:01,450 --> 00:03:05,010
+subunit احنا بنضمه في المقارنة مع مين؟ مع ال
+
+35
+00:03:05,010 --> 00:03:08,950
+killed لأن ال killed و ال purified كلا هما لا
+
+36
+00:03:08,950 --> 00:03:12,930
+يمتلق خصائص التكاثر فبالتالي هم بتشمعوا مع بعض في
+
+37
+00:03:12,930 --> 00:03:14,170
+هذه الصفات
+
+38
+00:03:17,350 --> 00:03:20,270
+هذا ال paper المهم تقريبا في المحاضرة تبعتنا اليوم
+
+39
+00:03:20,270 --> 00:03:24,230
+بنتحول أن نتطلع على كل العناصر و نقارن ما بين ال
+
+40
+00:03:24,230 --> 00:03:28,030
+live vaccine و ال killed vaccine و كمان مرة خلال
+
+41
+00:03:28,030 --> 00:03:32,470
+شرحنا للمقارنة ما بين التنين هنستفيد بعض النقاط
+
+42
+00:03:32,470 --> 00:03:36,630
+المتعلقة بال vaccination بشكل عام duration of
+
+43
+00:03:36,630 --> 00:03:42,950
+immunity فترة المناعة اللي بيعطيها ال killed أو ال
+
+44
+00:03:42,950 --> 00:03:47,730
+live vaccine بتعرف نتطلع على ال live longerkilled
+
+45
+00:03:47,730 --> 00:03:52,030
+vaccine shorter إذا بالفعل ال duration of immunity
+
+46
+00:03:52,030 --> 00:03:55,110
+إيش يعني ال duration of immunity؟ اللي هي فترة
+
+47
+00:03:55,110 --> 00:03:59,810
+المناعة سنتين تلاتة أربع خمسة تمام هذه فترات بتكون
+
+48
+00:03:59,810 --> 00:04:03,670
+أطول لما يكون ال vaccine live vaccine هنعرف كمان
+
+49
+00:04:03,670 --> 00:04:08,690
+شوية برضه ليش effectiveness of protection ال live
+
+50
+00:04:08,690 --> 00:04:14,010
+vaccine بيعطيني ميزة أفضل من مين من ال killed
+
+51
+00:04:14,010 --> 00:04:19,160
+vaccine برضه هنعرف ليشImmunoglobulin produced طلع
+
+52
+00:04:19,160 --> 00:04:24,820
+IGA و IGG فى مين؟ فى ال live بينما فى ال killed
+
+53
+00:04:24,820 --> 00:04:31,220
+مين بيطلع فقط و السر فى رقم واحد و رقم اتنين تمام
+
+54
+00:04:31,220 --> 00:04:38,380
+هو وجود ال IGال IGA ايش بيسموها ال antibody؟
+
+55
+00:04:38,380 --> 00:04:41,460
+بيسموه ال secretory antibody او ال soluble
+
+56
+00:04:41,460 --> 00:04:45,100
+antibody لأنه بيلاجيه في ال secretions بيلاجيه في
+
+57
+00:04:45,100 --> 00:04:49,040
+ال secretions وين secretions يعني؟ بيلاجيه في ال
+
+58
+00:04:49,040 --> 00:04:53,720
+mucus اللي بيغطي ال mucus membranes فلما الفيروس
+
+59
+00:04:53,720 --> 00:04:57,360
+اللي بيحب يرتبط بال mucus membrane ييجي على ال
+
+60
+00:04:57,360 --> 00:05:02,240
+mucus membrane حلاقه داومين antibody يمنعه اصلا من
+
+61
+00:05:02,240 --> 00:05:06,020
+انه يعمل infectionفبالفعل في عندي greater
+
+62
+00:05:06,020 --> 00:05:10,080
+protection لما أنا بستخدم اللي هو ال live vaccine
+
+63
+00:05:10,080 --> 00:05:16,060
+لأنه بنتجلي IgG و IgA cell mediated immunity وهذه
+
+64
+00:05:16,060 --> 00:05:20,940
+كمان يعني نقطة محورية في أي كلام ممكن يتكلموا عن
+
+65
+00:05:20,940 --> 00:05:25,000
+جهاز المناع ال cell mediated immunity قلنا عنها
+
+66
+00:05:25,000 --> 00:05:29,560
+محورية مظبوط محورية في ال viral infection كلها إذا
+
+67
+00:05:29,560 --> 00:05:35,530
+لم تتنشطالـ cell-mediated immunity لن يكون هناك
+
+68
+00:05:35,530 --> 00:05:41,330
+protection عالية ولا protection طويلة طبعا أكيد
+
+69
+00:05:41,330 --> 00:05:45,430
+حاجة تنشط لما الفيروس يتكثر لكن إذا الفيروس بتكترش
+
+70
+00:05:45,430 --> 00:05:51,610
+لأنه killed لن تتنشط إذا لحظة عندي IgA و IgG
+
+71
+00:05:51,610 --> 00:05:55,310
+بتضافة لمين للـ cell-mediated immunity هدولة
+
+72
+00:05:55,310 --> 00:05:59,840
+التلات عناصرهم اللي بيعطوا ال advantage لل live
+
+73
+00:05:59,840 --> 00:06:03,980
+vaccine طبعا هنتكلم عن disadvantage لل live
+
+74
+00:06:03,980 --> 00:06:09,260
+vaccine لكن في الآخر هنتكلم على شيء محدد وهو مزايا
+
+75
+00:06:09,260 --> 00:06:12,700
+ال live vaccine over اللي هو ال killed vaccine
+
+76
+00:06:12,700 --> 00:06:19,840
+Interruption of transmission of violent virusماذا
+
+77
+00:06:19,840 --> 00:06:22,720
+يعني Interruption of Transmission؟ انه ينتقل من
+
+78
+00:06:22,720 --> 00:06:25,560
+إنسان لإنسان لإنسان لإنسان تمام؟ هذا بيسموه
+
+79
+00:06:25,560 --> 00:06:30,540
+Interruption of Transmission برضه بيلاقي انه ال
+
+80
+00:06:30,540 --> 00:06:34,520
+live vaccine is more effective than اللي هو ال
+
+81
+00:06:34,520 --> 00:06:38,400
+kill vaccine هنا الآن بدأنا في مين؟ في ال
+
+82
+00:06:38,400 --> 00:06:43,420
+disadvantage Reversion to virusأنا لما أعطيت ال
+
+83
+00:06:43,420 --> 00:06:47,100
+live vaccine .. أعطيت ال live vaccine بناله ليش؟
+
+84
+00:06:47,100 --> 00:06:50,920
+على إنه ال vaccine هذا بيحتوي على فيروس مضعف فيروس
+
+85
+00:06:50,920 --> 00:06:56,680
+لن يكون له قدرة على أحداث المرض okay بتكاثر لكن هو
+
+86
+00:06:56,680 --> 00:07:00,540
+ضعيف و دي هذي الملعقة بيتعامل معاه بسهولة طب هل
+
+87
+00:07:00,540 --> 00:07:04,500
+ترى .. هل يمكن من ناحية نظرية أن يتحول هذا الفيروس
+
+88
+00:07:04,500 --> 00:07:09,020
+الضعيف و أنتوا دراستوا ال genetics في الفيروسات قد
+
+89
+00:07:09,020 --> 00:07:15,790
+..يتطفر سيلوتفر وعود يرجع ويصير شرس هل هذا ميزة
+
+90
+00:07:15,790 --> 00:07:20,030
+ولا عيب في ال life أكيد هتكون disadvantage انه
+
+91
+00:07:20,030 --> 00:07:24,570
+يتحول للشكل الشرس منه وبالتالي في خشية من هذا
+
+92
+00:07:24,570 --> 00:07:29,510
+الأمر بينما ال killed vaccine بالتأكيد لا لأنه هو
+
+93
+00:07:29,510 --> 00:07:34,710
+فيروس ميت stability at room temperature طبعا ال
+
+94
+00:07:34,710 --> 00:07:39,560
+killed vaccine هو stable لأنه أصلا ميت تمام؟وانا
+
+95
+00:07:39,560 --> 00:07:43,360
+مابديش ايه حي انا بدي ايه اصلا ميت لكن اذا انا بدي
+
+96
+00:07:43,360 --> 00:07:47,980
+vaccine صحيح اني ميت لكن برضه بديه حي مابنفعش
+
+97
+00:07:47,980 --> 00:07:51,920
+اخزنه على ال room temperature وانتبهوا لشغل معين
+
+98
+00:07:51,920 --> 00:07:57,060
+في موضوع ال vaccinationأحنا كل أطفالنا في قطاع
+
+99
+00:07:57,060 --> 00:08:01,260
+غزية بالطعام و ضد ال MMR اللي هو ال missiles و ال
+
+100
+00:08:01,260 --> 00:08:05,520
+mumps و الربلة العام الماضي و اللي سابقه كان فيه
+
+101
+00:08:05,520 --> 00:08:09,400
+انتشار للمumps اللي هو الأبوداج اللي هو الغدة
+
+102
+00:08:09,400 --> 00:08:13,600
+النكافية تمام؟ و الحقيقة مافيش تفسير .. مافيش
+
+103
+00:08:13,600 --> 00:08:18,140
+تفسير لهذا الانتشار إلا إن ال vaccination كانت مش
+
+104
+00:08:18,140 --> 00:08:22,160
+effectiveالان لو جينا دورنا على أسباب ليش ال
+
+105
+00:08:22,160 --> 00:08:26,260
+vaccines مش effective أحد أهم الأسباب هو عملية ال
+
+106
+00:08:26,260 --> 00:08:30,380
+storage اللي هي التخزين أو ال transport مثلا احنا
+
+107
+00:08:30,380 --> 00:08:35,460
+مستوردين ال .. ال .. ال vaccine من دولة X دولة X
+
+108
+00:08:35,460 --> 00:08:39,160
+بقعت علوان على ميناء الزدود و قعدت في ميناء الزدود
+
+109
+00:08:39,160 --> 00:08:42,880
+أكم يوم و بعدين أجتنا على معبر Ares و معبر Ares
+
+110
+00:08:42,880 --> 00:08:46,940
+قعدت لها ساعة و لا ساعتين بدون كهربا بدون كهربا
+
+111
+00:08:46,940 --> 00:08:52,110
+لأن فيها اسمها transport chainاللي هي سلسلة النقل،
+
+112
+00:08:52,110 --> 00:08:56,030
+الأصل أنه ال vaccine ينقل في تلاجة من المنشأ إلى
+
+113
+00:08:56,030 --> 00:09:00,510
+المستخدم، إلى المستخدم، قد يكون هناك فترة انقطاع
+
+114
+00:09:00,510 --> 00:09:03,410
+في هذا التخزين بسبب الظروف المعقدة اللي بنعيشها
+
+115
+00:09:03,410 --> 00:09:09,270
+احنا، هذا لو كان killed vaccine غالبا التأثير اللي
+
+116
+00:09:09,270 --> 00:09:13,260
+بيكون عليه minimum، بس لما يكون live vaccineهيموت
+
+117
+00:09:13,260 --> 00:09:16,960
+ال virus و بطل الغرض احنا كنا بدنا اياه اصلا live
+
+118
+00:09:16,960 --> 00:09:22,520
+فبطل يقد الغرض و باطناش greater ولا longer ولا
+
+119
+00:09:22,520 --> 00:09:25,640
+more effective اللي هو protection و قد نصاب
+
+120
+00:09:25,640 --> 00:09:28,520
+بالامراض زي مثلا في حالة اللي كنا ال mumps اللي
+
+121
+00:09:28,520 --> 00:09:33,720
+انتشر عندنا طبعا انا بشخصش المحدث انا هي اللي
+
+122
+00:09:33,720 --> 00:09:37,500
+بقولكوا احد الأسباب اللتي يمكن ان تكون اما ما
+
+123
+00:09:37,500 --> 00:09:39,080
+حددنا السبب الحقيقي
+
+124
+00:09:49,380 --> 00:09:53,010
+لو احنا بقول لو انه مش فعالمش فعالة، ماعطاش ال
+
+125
+00:09:53,010 --> 00:09:55,870
+effectiveness تبعه، فقط كلمة .. إيش معناها
+
+126
+00:09:55,870 --> 00:09:59,450
+stability؟ stability معناها ثبات، ثبات إنه يكون
+
+127
+00:09:59,450 --> 00:10:02,570
+بنفس الجودة اللي أنا من .. اللي أنا صنعته فيها،
+
+128
+00:10:02,570 --> 00:10:06,250
+تمام؟ فبالتالي إذا قلت الجودة، قلت فعاليته،
+
+129
+00:10:06,250 --> 00:10:10,150
+وبالتالي قلت اللي .. اللي هو الكفاءة تبع التمنيع،
+
+130
+00:10:10,150 --> 00:10:12,590
+اللي هو أعطاه ال .. ال protection لهذا الطفل أنا
+
+131
+00:10:12,590 --> 00:10:16,650
+بحكي مثلا عن أفضل نفس برا، لإن بحث إن الأطفال اللي
+
+132
+00:10:16,650 --> 00:10:18,450
+أخدوا الطفلين برا بقوا مستقبل نفسهم
+
+133
+00:10:24,640 --> 00:10:28,280
+و اوصلت برضه بمعرفة فترة يعني اللي خطأ المكان اللي
+
+134
+00:10:28,280 --> 00:10:34,850
+مجلس فيه back stageلو غالبا .. غالبا السلالة ..
+
+135
+00:10:34,850 --> 00:10:37,710
+السلالة هي سلالة واحدة، لو في أكتر من سلالة نجونا
+
+136
+00:10:37,710 --> 00:10:41,730
+نفس ال .. نفس القصة، فبنكون incidentally، انت أصلا
+
+137
+00:10:41,730 --> 00:10:45,030
+ممكن ما .. مااخدتش الجرعات تلاتة تنام اللي هم ال
+
+138
+00:10:45,030 --> 00:10:48,250
+.. ال .. ال .. اللي بياخدهم الأطفال، وممكن يكون
+
+139
+00:10:48,250 --> 00:10:49,870
+نفس الخلل اللي صار ما .. اللي في نفسي، يعني
+
+140
+00:10:49,870 --> 00:10:52,870
+coincidence إن الخلل في نفس المكانين ل .. لنفس
+
+141
+00:10:52,870 --> 00:10:57,500
+السبب، لنفس السببالنقطة الأخيرة في الجرس اللي
+
+142
+00:10:57,500 --> 00:11:01,660
+طبعنا انه execution of vaccine and transmission to
+
+143
+00:11:01,660 --> 00:11:05,940
+non-immune contact مش عارف هنعتبرها مين زي و اللي
+
+144
+00:11:05,940 --> 00:11:12,040
+عيب في الجمعة الأخيرة انه ال live vaccine ممكن لو
+
+145
+00:11:12,040 --> 00:11:16,060
+الإنسان أعطينا مثلا oral زي ال polio، شباب و أطفال
+
+146
+00:11:17,280 --> 00:11:22,120
+واتكاثر اللي هو ال .. ال .. ال virus في الأمعاء و
+
+147
+00:11:22,120 --> 00:11:25,420
+بدأ يصير له إفراز في البوراز أكرمكم الله تمام؟
+
+148
+00:11:25,420 --> 00:11:29,520
+الان هذا الإفراز ممكن إذا كان في منطقة ال sewage
+
+149
+00:11:29,520 --> 00:11:34,700
+system تبعها سيء ممكن ينتقل لمين؟ لآخرين، هل هذا
+
+150
+00:11:34,700 --> 00:11:41,380
+سيء ولا إيجابي؟ إيش رأيكم؟هو ممكن يكون سيء و ممكن
+
+151
+00:11:41,380 --> 00:11:44,700
+يكون إيجابي .. ممكن يكون إيجابي يتضل ال virus ..
+
+152
+00:11:44,700 --> 00:11:49,080
+يتضل ال virus على ما هو بمعنى إنه ماصلوش reversion
+
+153
+00:11:49,080 --> 00:11:53,360
+فهو بواقع الأمر احنا جاليم بنطعم في ال .. الاخرين
+
+154
+00:11:53,360 --> 00:11:56,260
+دون أنه يعطاهم إيه؟ تطايم .. لكن لو صارله
+
+155
+00:11:56,260 --> 00:12:00,100
+reversion للأسف لل virulence احنا بننقل المرض
+
+156
+00:12:00,100 --> 00:12:03,000
+الحقيقي لمين؟ لها و لأطفال .. إذن هذه النقطة
+
+157
+00:12:03,000 --> 00:12:09,690
+الأخيرة يعني ممكن تكون سلاح ده حدال ..In general,
+
+158
+00:12:10,090 --> 00:12:12,810
+live vaccines are preferred to vaccines containing
+
+159
+00:12:12,810 --> 00:12:16,190
+killed viruses because their protection is greater
+
+160
+00:12:16,190 --> 00:12:19,850
+and longer. طبعا كل الجدول كان بيأكد إن ال live
+
+161
+00:12:19,850 --> 00:12:24,910
+vaccine أفضل لكن بنا نفهم شغل واحدة احنا مالجأناش
+
+162
+00:12:24,910 --> 00:12:29,670
+لل killed vaccine إلا أكيد في أسباب مثلا ماجدرناش
+
+163
+00:12:29,670 --> 00:12:34,510
+نحصل على سلالة مضاعفة يمكن أن تكون آمنة و نعطيها
+
+164
+00:12:34,510 --> 00:12:39,180
+للمرضى، مظبوط؟عشان انا دايما لما كنت اقولكوا
+
+165
+00:12:39,180 --> 00:12:45,000
+السؤال الغبي اللى ممكن ينسقل ويتجاوب عليها برضه
+
+166
+00:12:45,000 --> 00:12:49,980
+بطريقة غبية مين افضل؟ مين افضل؟ السؤال الصح كان
+
+167
+00:12:49,980 --> 00:12:53,660
+لازم يكون مين افضل في اي situation لازم نذكر ال
+
+168
+00:12:53,660 --> 00:12:57,600
+situation و بعدين نقول مين افضل؟وال live vaccines
+
+169
+00:12:57,600 --> 00:13:00,680
+the virus multiplies in the host producing
+
+170
+00:13:00,680 --> 00:13:04,120
+prolonged antigenic stimulus لأنه بتكاثر في ال
+
+171
+00:13:04,120 --> 00:13:09,980
+host بيطلع stimuli كويسة بيطلع IgA جنه مين و IgG
+
+172
+00:13:09,980 --> 00:13:13,160
+are elicited when the vaccine is administered by
+
+173
+00:13:13,160 --> 00:13:16,580
+the natural route كلمة natural route من وين بدخل
+
+174
+00:13:16,580 --> 00:13:20,080
+ال vaccine من وين بدخل الفيروس أساسا وانا افترض من
+
+175
+00:13:20,080 --> 00:13:25,650
+ال oral cavity إذا أعطيته oral هذا الكلام بتحققلكن
+
+176
+00:13:25,650 --> 00:13:30,250
+إذا هو oral و قطعه انترامسكولر هذا الأمر لن يتحقق
+
+177
+00:13:30,250 --> 00:13:37,410
+لأنه لازم يمر عبر اللي هو ال natural route زي
+
+178
+00:13:37,410 --> 00:13:39,730
+ال polio vaccine زي ما حكينا it is given already
+
+179
+00:13:39,730 --> 00:13:42,470
+طبعا احنا بنعرف أنه أصلا ال polio vaccine بينتقل
+
+180
+00:13:42,470 --> 00:13:48,110
+عن طريق اللي هو ال fecal oral routeKill vaccine
+
+181
+00:13:48,110 --> 00:13:52,390
+which are usually given intramuscularly يعني في
+
+182
+00:13:52,390 --> 00:13:56,390
+العضل مطلوب نعطيها في العضل Do not stimulate a
+
+183
+00:13:56,390 --> 00:14:03,090
+major IgA response والسبب واضح مافيش تكاثر تمام
+
+184
+00:14:03,090 --> 00:14:07,110
+مافيش cell mediated immunity وبالتالي مافيش
+
+185
+00:14:07,110 --> 00:14:11,030
+response إلا حاجة واحدة لل IgG ممكن يطلعناها طبعا
+
+186
+00:14:11,030 --> 00:14:14,790
+ال IgM بالتأكيدبس احنا اللي .. اللي .. اللي بنتمد
+
+187
+00:14:14,790 --> 00:14:18,370
+عليه for the longer protection مش ال IGM، مين اللي
+
+188
+00:14:18,370 --> 00:14:21,750
+بنتمد عليه هنا؟ ال IGG، لأن هو اللي بيبقى لفترات
+
+189
+00:14:21,750 --> 00:14:27,710
+طويلة Okay، in the absence of replication, no
+
+190
+00:14:27,710 --> 00:14:32,210
+viral epitopes are presented in association with
+
+191
+00:14:32,210 --> 00:14:35,630
+class I MHC protein and the cytotoxic T cell
+
+192
+00:14:35,630 --> 00:14:39,100
+response is not activatedالجملة الأخيرة بتوضح أن
+
+193
+00:14:39,100 --> 00:14:46,160
+لماذا لا يوجد لدينا cytosic T cell activation أو
+
+194
+00:14:46,160 --> 00:14:51,000
+cell-mediated immunity بالأعلى؟ لماذا؟ لأنه ماصارش
+
+195
+00:14:51,000 --> 00:14:56,440
+replication، ماصارش فيه antigen presentation من
+
+196
+00:14:56,440 --> 00:14:59,880
+خلال الـ macrophage اللي بتقدمه للـ T cell
+
+197
+00:14:59,880 --> 00:15:03,240
+فبالتالي مافيش T cell activation، هذه نقطة كتير
+
+198
+00:15:03,240 --> 00:15:03,780
+مهمة
+
+199
+00:15:06,290 --> 00:15:09,470
+although live vaccine stimulate a long-lasting
+
+200
+00:15:09,470 --> 00:15:13,770
+response, booster doses هي مصطلح لابد أن نتعرف
+
+201
+00:15:13,770 --> 00:15:18,110
+عليه، كلمة booster dose هي الجرعة الدائمة أو
+
+202
+00:15:18,110 --> 00:15:21,910
+الجرعة التنشيطية، كلمة post معناها يدعم، تمام؟
+
+203
+00:15:21,910 --> 00:15:23,850
+فbooster dose هي الجرعة الدائمة
+
+204
+00:15:28,630 --> 00:15:32,590
+وانه على الرغم من انه ال live vaccine بيعمل
+
+205
+00:15:32,590 --> 00:15:35,530
+stimulation ل .. ل .. ل .. يعني long lasting
+
+206
+00:15:35,530 --> 00:15:39,010
+immunity في الفترة الطويلة إلا ان احنا نحتاج إلى
+
+207
+00:15:39,010 --> 00:15:42,370
+جرعة تنشطية مثل .. مثال دلوقتي على ال missiles و
+
+208
+00:15:42,370 --> 00:15:47,390
+ال polio vaccine طبعا احنا درسنا في ال genetics
+
+209
+00:15:47,390 --> 00:15:51,400
+تبع الفيروسات موضوع كتير كان مهم و لطيفاللي هو
+
+210
+00:15:51,400 --> 00:15:55,560
+المتعلق بال conditional lethal mutation، مين فاكر
+
+211
+00:15:55,560 --> 00:16:00,120
+المصطلح؟ conditional lethal mutation، لما اتكلمنا
+
+212
+00:16:00,120 --> 00:16:05,000
+عن طفرة، في إيها permissive و repressive، يعني
+
+213
+00:16:05,000 --> 00:16:09,500
+ظروف تسمح وظروف تمنع، وكان ال influenza vaccine
+
+214
+00:16:09,500 --> 00:16:12,640
+أحد الأشياء اللي اتكلمنا عنها، اللي هو temperature
+
+215
+00:16:12,640 --> 00:16:16,780
+sensitive، بيتكاتر في الأنف، لكن لو نزل على ال
+
+216
+00:16:16,780 --> 00:16:19,020
+lower respiratory tract، ما بيتكاتر في lower
+
+217
+00:16:19,020 --> 00:16:20,300
+respiratory tract
+
+218
+00:16:23,440 --> 00:16:27,980
+هناك ثلاث .. خلّيني أقول مخاوف .. concerns ..
+
+219
+00:16:27,980 --> 00:16:35,020
+تمام؟ من استخدام الـ live vaccines أنا ذكرت واحد
+
+220
+00:16:35,020 --> 00:16:38,760
+منهم .. إيش الأول الذي ذكرته؟ إنه الـ reversion
+
+221
+00:16:38,760 --> 00:16:44,020
+الـ reversion اللي هو إنه اتحول من ال weak form أو
+
+222
+00:16:44,020 --> 00:16:47,780
+ال attenuated form إلى ال virulent form هذا يسمى
+
+223
+00:16:47,780 --> 00:16:52,030
+reversionThey are composed of attenuated viral
+
+224
+00:16:52,030 --> 00:16:55,630
+mutant which can revert to virulence either during
+
+225
+00:16:55,630 --> 00:16:59,910
+vaccine production or in the immunized person يعني
+
+226
+00:16:59,910 --> 00:17:04,790
+الخوف مش بس في الإنسان حتى و انا بننتج ال vaccine
+
+227
+00:17:04,790 --> 00:17:08,350
+.. انا كيف بننتج ال vaccine؟ بنكاثر ال virus
+
+228
+00:17:08,350 --> 00:17:13,050
+مظبوط، بنكاثر ال virus، بنكاتره، و بعدين بنجسمه
+
+229
+00:17:13,050 --> 00:17:20,120
+وحدات، بنقول أن الوحدة أو ال shotتحتوي على X
+
+230
+00:17:20,120 --> 00:17:23,640
+number من هذه الفيروسات، هذه الفيروسات يتصرف انها
+
+231
+00:17:23,640 --> 00:17:28,260
+مضاعفة، تخيل لو أنا بنتج فيها صار فيها تفرط
+
+232
+00:17:28,260 --> 00:17:33,240
+واتحولت لشرسة، تمام؟ لذلك ال vaccine should be
+
+233
+00:17:33,240 --> 00:17:38,580
+tested before dispatching، لازم ينفحص ويعمل
+
+234
+00:17:38,580 --> 00:17:42,540
+quality control قبل مين؟ قبل اللي هو توزيعه على
+
+235
+00:17:42,540 --> 00:17:48,670
+الجمهورطب هذا مسيطر عليه لإنه فيه إمكانية quality
+
+236
+00:17:48,670 --> 00:17:52,290
+control، بس الآن المشكلة وين؟ إنه صير virgin اللي
+
+237
+00:17:52,290 --> 00:17:55,810
+في مين في المرضى نفسهم اللي احنا عطيناهم هذا ال
+
+238
+00:17:55,810 --> 00:17:58,710
+vaccinereversion to the virulence during
+
+239
+00:17:58,710 --> 00:18:00,950
+production can be detected by quality control زي
+
+240
+00:18:00,950 --> 00:18:05,010
+ما حكينا، اللي هي إجراءات السيطرة في المصانع، but
+
+241
+00:18:05,010 --> 00:18:07,610
+there is no test to predict whether reversion will
+
+242
+00:18:07,610 --> 00:18:10,870
+occur in immunized individuals، هذه نقطة اللي احنا
+
+243
+00:18:10,870 --> 00:18:14,330
+ذكرناها of the commonly used live vaccine, only
+
+244
+00:18:14,330 --> 00:18:17,350
+polio vaccine has had problems regarding
+
+245
+00:18:17,350 --> 00:18:23,050
+revertence، يعني بس ال polio اللي واجهنا معه هذه
+
+246
+00:18:23,050 --> 00:18:26,940
+المشكلةميسلز والمامس والربيلة وفارسيلة vaccine
+
+247
+00:18:26,940 --> 00:18:30,900
+have not يعني كل هدولة اللي محتوين عليها اللي هم
+
+248
+00:18:30,900 --> 00:18:36,080
+ال live vaccine لم .. لم نواجه معهم مشكلة التحول
+
+249
+00:18:36,080 --> 00:18:39,860
+فقالوا لنا مامين مع ال poly الكلام اللي حكيته عن
+
+250
+00:18:39,860 --> 00:18:43,220
+ال moms قبل قليل بأكد ان ال moms تمام هو من
+
+251
+00:18:43,220 --> 00:18:46,400
+الفيروسات ال .. ال .. ال .. او من ال vaccines اللي
+
+252
+00:18:46,400 --> 00:18:50,420
+بنعطيها live attenuated فسوق تخزين ممكن يقلل جنة
+
+253
+00:18:50,420 --> 00:18:54,660
+من كفائتهاeven if the virus in the live vaccine
+
+254
+00:18:54,660 --> 00:18:58,440
+does not revert it can still cause disease because
+
+255
+00:18:58,440 --> 00:19:02,980
+.. و هذا الكلام احنا بنشوفه ان بعض الأطفال .. بعض
+
+256
+00:19:02,980 --> 00:19:06,080
+الأطفال اللي لابدوا انه يتطعموا بيوصابوا بالمرض
+
+257
+00:19:06,080 --> 00:19:10,100
+نفسه .. بيوصابوا بالمرض نفسه و يمكن اكبر دليل على
+
+258
+00:19:10,100 --> 00:19:13,260
+ذلك انه مرض الجدري .. الجدري اللي هو احنا كنا
+
+259
+00:19:13,260 --> 00:19:17,060
+انتهى من كوكب الأرضمتى بقى واجفوا الفاكسين؟ واجفوا
+
+260
+00:19:17,060 --> 00:19:21,000
+الفاكسين لما صار عدد حالات الإصابة بالمرض من ال
+
+261
+00:19:21,000 --> 00:19:24,700
+vaccination أعلى من حالات الإصابة بال natural
+
+262
+00:19:24,700 --> 00:19:29,340
+route فبتاع اللي جالب ما احنا نعيش أجلان نوجف فبعض
+
+263
+00:19:29,340 --> 00:19:33,440
+الأحيان أصلا الطفل اللي بيتطعم بيكون منعته منخفضة
+
+264
+00:19:33,440 --> 00:19:37,020
+أو مصاب بمرض معين لذلك الطفل اللي عنده حمة غالبا
+
+265
+00:19:37,020 --> 00:19:40,620
+كسمة عامة لا يطعم يعني بروحله بيقوله باجلوله
+
+266
+00:19:40,620 --> 00:19:45,350
+التطايم تبعه باجلوله التطايم تبعهخاصة اقولكوا مع
+
+267
+00:19:45,350 --> 00:19:48,270
+فالمين with reduced cell immunity
+
+268
+00:19:52,300 --> 00:19:56,600
+الثانية المهمة هي أن الفاكسين يمكن أن يكون اكسكرت
+
+269
+00:19:56,600 --> 00:20:01,140
+بالشخص اللي اميونيزه. قلنا لكم ان مريض ال بوليو،
+
+270
+00:20:01,140 --> 00:20:04,420
+عفوا مش مريض ال بوليو اللي أخد تطعيم ال بوليو
+
+271
+00:20:04,420 --> 00:20:08,380
+الفاكسين أو الفيروس الان بتكاتر في داخل الأمعاء
+
+272
+00:20:08,380 --> 00:20:12,160
+ويصير له shooting مع البراز ويمكن انتقل لمين؟
+
+273
+00:20:12,160 --> 00:20:17,300
+لأخرين وانا قلت عنها جملةthis is a double edged
+
+274
+00:20:17,300 --> 00:20:22,380
+sword يعني سلاح ذو حدين وزي ما قلنالكوا إذا كان
+
+275
+00:20:22,380 --> 00:20:28,380
+ضال هو weak فبكون كويس إنه بعمل immunization لكن
+
+276
+00:20:28,380 --> 00:20:32,660
+إذا كان صار له reversion هنا المصيبة إنه أنا قاعد
+
+277
+00:20:32,660 --> 00:20:35,820
+ب unsure ال polio طبعا أنتم مش متخيلين جداش ال
+
+278
+00:20:35,820 --> 00:20:42,810
+polio مرض خطيرالـ Polio خطير جدا من ناحيتين انه
+
+279
+00:20:42,810 --> 00:20:47,970
+بيحدث ضرر permanent اللي هو زي الشرل تمام و نسبة
+
+280
+00:20:47,970 --> 00:20:51,290
+الوفيات ايضا كمان فيه عالية يعني الأطفال اللي
+
+281
+00:20:51,290 --> 00:20:55,110
+بيوصابوا ممكن جزء منهم جزء كبير منهم ايه يموت و
+
+282
+00:20:55,110 --> 00:20:59,350
+جزء اخر ليشفى يصير عنده إعاقة دائمة زي اللي احنا
+
+283
+00:20:59,350 --> 00:21:03,050
+بنشوفهم في كبار السن اللي من جيليا أو أكبر و بيكون
+
+284
+00:21:03,050 --> 00:21:07,290
+عنده بيعرج هذا غالبا بيكون ايه من شرل من من Polio
+
+285
+00:21:07,290 --> 00:21:08,330
+او من شرل الأطفال
+
+286
+00:21:13,230 --> 00:21:18,510
+الـ third concern أنه احنا بننتج ال .. ال vaccine
+
+287
+00:21:18,510 --> 00:21:21,230
+.. بننتج ال vaccine زي ما حكينالكم من خلال ten مية
+
+288
+00:21:21,230 --> 00:21:27,450
+إيه؟ ال virus، الآن تخيل لو أنه في virus تاني عمل
+
+289
+00:21:27,450 --> 00:21:32,230
+contamination، تمام؟ و نما، في ال micro كنا نركز
+
+290
+00:21:32,230 --> 00:21:36,860
+على مصطلحpure culture فاكرين كلمة pure culture؟ ان
+
+291
+00:21:36,860 --> 00:21:40,540
+الميكروب اللي بدنا يه لازم يكون نقي one سلالة
+
+292
+00:21:40,540 --> 00:21:44,000
+واحدة و أحد هذه الأسباب كانت production of
+
+293
+00:21:44,000 --> 00:21:47,460
+vaccines يعني لما بده انتج vaccine هذا ال vaccine
+
+294
+00:21:47,460 --> 00:21:51,020
+نجب ان يكون محتوي على نوع واحد من اللي هو
+
+295
+00:21:51,020 --> 00:21:55,300
+الفيروسات لكن دائما هناك خشية وانت بتعرفوا بأحد
+
+296
+00:21:55,300 --> 00:22:00,890
+نظريات نشوء مرض ال aids وانتقاله من الحيواناتإلى
+
+297
+00:22:00,890 --> 00:22:04,150
+الإنسان هو ال vaccination إنه ال vaccine اللي كان
+
+298
+00:22:04,150 --> 00:22:11,430
+يستخدم تمام تلوث طبعا ال vaccine نمية على خلايا من
+
+299
+00:22:11,430 --> 00:22:17,410
+قرود تمام ال culture تبعت قرود ففي نظرية بتقول إنه
+
+300
+00:22:17,410 --> 00:22:21,650
+ال vaccine هذا هو اللي نقل ال aids من القرود إلى
+
+301
+00:22:21,650 --> 00:22:27,330
+اللي هو الإنسان هذه كانت نظرية لكن ليست مثبتةلكن
+
+302
+00:22:27,330 --> 00:22:31,230
+الفكرة .. الفكرة ان انا دائما عندي هذه الخشية ..
+
+303
+00:22:31,230 --> 00:22:33,950
+عندي هذه الخشية ان يكون other viruses
+
+304
+00:22:33,950 --> 00:22:40,410
+contaminating this vaccine طبعا
+
+305
+00:22:40,410 --> 00:22:45,810
+هذا ال .. هذا ال .. هذا الخطر بيشمل كل من ال
+
+306
+00:22:45,810 --> 00:22:49,590
+killed و ال live vaccine لان كلاهما احنا اصلا
+
+307
+00:22:49,590 --> 00:22:53,930
+بنكاثرهم واحد بنقتله و واحد اما بنضعفه و هو اصلا
+
+308
+00:22:53,930 --> 00:22:58,560
+ضعيف تمام؟فال .. ال .. الاحتمالية التلوث هتكون في
+
+309
+00:22:58,560 --> 00:23:03,500
+مين؟ في التنين، لكن و انا أخطر في ال life، لأن ال
+
+310
+00:23:03,500 --> 00:23:07,760
+life لا أعرجه انا لمعالجة حرارية ولا معالجة
+
+311
+00:23:07,760 --> 00:23:12,260
+كيميائية بعد ذلك لقتل الفيروسفي الـ killed أنا
+
+312
+00:23:12,260 --> 00:23:16,180
+بعالجه ال vaccine وبالتالي حتى لو كان في
+
+313
+00:23:16,180 --> 00:23:18,760
+contaminating virus إيش بيصير في ال contaminated
+
+314
+00:23:18,760 --> 00:23:21,640
+virus هذا؟ it's killed حيصيرله killing برضه
+
+315
+00:23:21,640 --> 00:23:26,040
+فالتنين اللي أنا أعطتهم للشخص بيكونوا killed الدلر
+
+316
+00:23:26,040 --> 00:23:31,620
+تبعه بيكون خفيف أو قليل بينما ال live هنا تكمن
+
+317
+00:23:31,620 --> 00:23:38,020
+اللي هو المشكلة في كان مثال مشهور حاجة يسموها live
+
+318
+00:23:38,020 --> 00:23:43,500
+semen vacillating virus 40وهذا بيسموه in apparent
+
+319
+00:23:43,500 --> 00:23:47,760
+passenger virus كلمة in apparent passenger virus
+
+320
+00:23:47,760 --> 00:23:54,340
+يعني مسافر، يعني بيعملش إشي، بيعملش حيرIn monkey
+
+321
+00:23:54,340 --> 00:23:57,020
+kidney cells and contaminated some lots of
+
+322
+00:23:57,020 --> 00:24:02,080
+poliovirus vaccine was resistant to formaldehyde
+
+323
+00:24:02,080 --> 00:24:08,220
+هذا الفيروس الوه سيميان vaculating virus طبعا لما
+
+324
+00:24:08,220 --> 00:24:12,220
+اكتشفوا القمر كان فيه هلأ وخشية كبيرة لكن لحظة
+
+325
+00:24:12,220 --> 00:24:17,000
+وحظة وردنا ان هذا الفيروس ما بيعمل اي ضرر للانسان
+
+326
+00:24:17,000 --> 00:24:24,000
+او على اقل هكذا وصلت لنا المعلومةطبعا هو .. ليه ..
+
+327
+00:24:24,000 --> 00:24:28,340
+ليش كان القلق؟ لأن هو مشهور الـ SV40 أنه بيعمل نوع
+
+328
+00:24:28,340 --> 00:24:32,860
+من الـ Sarcomas في مين؟ في القوارض لكن لحظة و حق
+
+329
+00:24:32,860 --> 00:24:37,860
+كما ذكرنا لكم أنه ماوجدوش أنه بيعمل هذا الكلام في
+
+330
+00:24:37,860 --> 00:24:41,540
+الإنسان إذا ميت تلت مخاوف من استخدام ال life
+
+331
+00:24:41,540 --> 00:24:45,680
+vaccine رقم واحد Reversion من attenuated إلى
+
+332
+00:24:45,680 --> 00:24:49,320
+virulent رقم اتنان رقم اتنان
+
+333
+00:24:57,220 --> 00:25:04,400
+رقم اتنين طب رقم تلاتة انه يكون فيه contamination
+
+334
+00:25:04,400 --> 00:25:07,880
+رقم اتنين يا جماعة اللي قلنالكوا انه يصيرله
+
+335
+00:25:07,880 --> 00:25:11,720
+execution و distribution في اللي هو ال community
+
+336
+00:25:14,450 --> 00:25:19,570
+Additional concerns يعني هذه مخاوف إضافية Certain
+
+337
+00:25:19,570 --> 00:25:22,150
+viral vaccines namely influenza, measles, mumps
+
+338
+00:25:22,150 --> 00:25:25,410
+and yellow fever vaccines are grown in chick
+
+339
+00:25:25,410 --> 00:25:30,790
+embryos تعرفوا الكتكوت أو ال .. ال .. ال chick
+
+340
+00:25:30,790 --> 00:25:34,410
+embryo وسيلة من وسائل استخدامنا لتنمية اللي هو
+
+341
+00:25:34,410 --> 00:25:40,620
+الفيروسات فلحد الآن هناكشركات إنتاجها لهذه ال
+
+342
+00:25:40,620 --> 00:25:44,080
+vaccines معتمدة على تنمية الفيروسات في الـ chick
+
+343
+00:25:44,080 --> 00:25:49,500
+embryo طب لو واحد عنده حساسية من البيض أو مشتقاته
+
+344
+00:25:49,500 --> 00:25:53,560
+و أعطيناه ال vaccine اللي بالتأكيد مهما حاولنا
+
+345
+00:25:53,560 --> 00:25:59,020
+نبقيه ستبقى فيه بعض متبقيات من مين من اللي هو منتج
+
+346
+00:25:59,020 --> 00:26:03,660
+للبيض فممكن يصير فينا anaphylactic reaction to it
+
+347
+00:26:03,660 --> 00:26:06,380
+إيش anaphylactic reaction؟الـ Anaphylactic
+
+348
+00:26:06,380 --> 00:26:09,240
+Reaction اللي هي الـ Immediate Type
+
+349
+00:26:09,240 --> 00:26:13,080
+Hypersensitivity أكيد كل كسمته في شخص جرسته نحلة
+
+350
+00:26:13,080 --> 00:26:18,060
+أو أكل شيء معين أو لمس شيء معين وصار عنده أعراض أو
+
+351
+00:26:18,060 --> 00:26:22,440
+أخد إبرة إجريت بنسالين مثلا مشهورة هذه و بعد مصاعة
+
+352
+00:26:22,440 --> 00:26:26,120
+بدأ يظهر عليه أعراض إحمرار وانتفاخ وإلى أخرى هذه
+
+353
+00:26:26,120 --> 00:26:29,860
+بيسموها Anaphylactic Shock وقد تكون قاتلة عند
+
+354
+00:26:29,860 --> 00:26:30,260
+البعض
+
+355
+00:26:36,580 --> 00:26:40,860
+ممكن تكون هذا السبب ال anaphylactic shock لكن
+
+356
+00:26:40,860 --> 00:26:44,040
+مافيش خشية انه اذا كان في بعض الناس عندهم حساسية
+
+357
+00:26:44,040 --> 00:26:48,080
+للريش نفسه للريش نفسه مافيش خشية من انه ناخد ال
+
+358
+00:26:48,080 --> 00:26:51,500
+vaccine اللي اتنمى على مين على ال chicken embryo
+
+359
+00:26:51,500 --> 00:26:56,280
+او ال chick embryoالان نيجي لان لـ disadvantages
+
+360
+00:26:56,280 --> 00:27:01,660
+of the killed vaccine احنا حاولنا انه نسويق لمين
+
+361
+00:27:01,660 --> 00:27:06,780
+لل live vaccine ان هو الأفضل و في الآخر مررنا على
+
+362
+00:27:06,780 --> 00:27:12,120
+مجموعة من المخاوف تلاتة و لاحقناهم بالحساسية الان
+
+363
+00:27:12,120 --> 00:27:16,060
+كلها معاناة disadvantages لل killed vaccine طبعا
+
+364
+00:27:16,060 --> 00:27:19,740
+الجدول اللي احنا عرضناه في البداية الحقيقة انه it
+
+365
+00:27:19,740 --> 00:27:22,700
+says it all يعني بيقول كل الكلام لكن بشيء من
+
+366
+00:27:22,700 --> 00:27:27,190
+التفصيل الآنThey induce a shorter, shorter يعني
+
+367
+00:27:27,190 --> 00:27:31,290
+فترة أقصر, duration of protection, are less
+
+368
+00:27:31,290 --> 00:27:35,330
+protective وكنا less protective لها سبب إنه بنتلش
+
+369
+00:27:35,330 --> 00:27:39,390
+كام كافي من ال IGA مابنشطش اللي هو ال cell
+
+370
+00:27:39,390 --> 00:27:42,490
+mediated immunity وعرفنا السبب إنه مابنشطش ال cell
+
+371
+00:27:42,490 --> 00:27:47,130
+mediated immunity لإنه لإنه إيه؟ لإنه مابصلش فيه
+
+372
+00:27:47,130 --> 00:27:50,530
+antigen presentation من ال macro phage لل T cell
+
+373
+00:27:50,530 --> 00:27:53,720
+وبالتالي ال T cell ما بتشتغل في هذا الحالinduces
+
+374
+00:27:53,720 --> 00:27:56,520
+fewer IgA antibodies، there is no .. there is a
+
+375
+00:27:56,520 --> 00:27:58,540
+potential problem that the inactivation process
+
+376
+00:27:58,540 --> 00:28:00,160
+might be inadequate
+
+377
+00:28:04,410 --> 00:28:09,570
+لكن حلو في الـ quality control وانه في خش دائما ان
+
+378
+00:28:09,570 --> 00:28:13,490
+ال inactivation مايكونش adequate زي ما شوفنا قبل
+
+379
+00:28:13,490 --> 00:28:18,290
+قليل ال stem vacillating virus SV40 كان resistant
+
+380
+00:28:18,290 --> 00:28:21,330
+to formaldehyde طب احنا ال formaldehyde هو اللي
+
+381
+00:28:21,330 --> 00:28:26,740
+مستخدم ولا مين لل inactivationأما الـ formaldehyde
+
+382
+00:28:26,740 --> 00:28:29,660
+مثلا الـ concentration غير كافية أو الـ time
+
+383
+00:28:29,660 --> 00:28:34,480
+للتعرض غير كافي فدائما الخشية موجودة لكن يتغلب على
+
+384
+00:28:34,480 --> 00:28:38,160
+هذه الخشية كما ذكرنا لكم بالـ quality control
+
+385
+00:28:38,160 --> 00:28:39,600
+للويروس
+
+386
+00:28:41,480 --> 00:28:44,440
+although this is rare it happens in the early days
+
+387
+00:28:44,440 --> 00:28:47,300
+of the manufacture of the killed polio vaccine
+
+388
+00:28:47,300 --> 00:28:52,320
+يعني طبعا هذه المخاوف نشأت من أوضاع حقيقية مش
+
+389
+00:28:52,320 --> 00:28:56,120
+تخيّلية و دي جعل بالك أنه كان في مثال على ال polio
+
+390
+00:28:56,120 --> 00:28:59,820
+vaccineاحنا في نوع من ال polio vaccine خدوا بالكوا
+
+391
+00:28:59,820 --> 00:29:04,020
+بلاش يصير confusion، في منه نوعين ال vaccine، في
+
+392
+00:29:04,020 --> 00:29:07,960
+نوع بينعطى intramuscular وهذا ال killed وواحد
+
+393
+00:29:07,960 --> 00:29:11,700
+بينعطى oral وهذا اللي هو alive attenuated، إذا في
+
+394
+00:29:11,700 --> 00:29:16,900
+عندي two vaccines لل polio، واحد inactivated وواحد
+
+395
+00:29:16,900 --> 00:29:18,820
+attenuated، يعني killed و alive
+
+396
+00:29:22,460 --> 00:29:26,300
+ال advantages تبعت ال killed vaccine هي ال
+
+397
+00:29:26,300 --> 00:29:30,140
+disadvantages تبعت مين تحت ال live vaccine مثلا
+
+398
+00:29:30,140 --> 00:29:32,780
+they cannot revert to viral انسمها، يعني ميتين،
+
+399
+00:29:32,780 --> 00:29:36,940
+ميتين يعني، they are more heat stable أكتر
+
+400
+00:29:36,940 --> 00:29:40,540
+وبالتالي تخزينهممش ضروري بالتلاجة ممكن اتلهم
+
+401
+00:29:40,540 --> 00:29:42,800
+temperature لاجيهم على ال rough الصيدلية او في
+
+402
+00:29:42,800 --> 00:29:47,400
+الأماكن الأخرى يعني فيش شي خشية من انهم يخربوا
+
+403
+00:29:47,400 --> 00:29:51,700
+لأنهم more stable الاولانيين اللي هم ال live لأ
+
+404
+00:29:51,700 --> 00:29:54,700
+احنا بدناهم live فلو تركناهم اتلهم temperature
+
+405
+00:29:54,700 --> 00:29:58,860
+ممكن يصير فيهم ضرر وبالمناسبة انا ذكرت هذه الجملة
+
+406
+00:29:59,460 --> 00:30:02,660
+في ال cultivation of viruses لما كنا نتكلم عن
+
+407
+00:30:02,660 --> 00:30:05,520
+زراعة الفيروس نقول لكوا ان الفيروسات هي اللي هتترك
+
+408
+00:30:05,520 --> 00:30:09,580
+على رقم temperature إذا كان و لابد بدنا ننتظر
+
+409
+00:30:09,580 --> 00:30:13,100
+خلينا نحتفظ فيها at four degrees centigrade و هذا
+
+410
+00:30:13,100 --> 00:30:18,280
+نقطة برضه مهمة طيب في عندي حد اسمه pre exposure
+
+411
+00:30:18,280 --> 00:30:23,640
+versus عارفينش بعد versus أكيد عارفينها Barcelona
+
+412
+00:30:23,640 --> 00:30:28,720
+versus Real Madrid أه تعرفوا هذا طيبإيش مات pre
+
+413
+00:30:28,720 --> 00:30:32,460
+exposure أو post exposure؟ لما أنا بقول أبطعم
+
+414
+00:30:32,460 --> 00:30:35,980
+الطفل الصغير اللي موجود حديثا، أنا ابطعمه قبل ما
+
+415
+00:30:35,980 --> 00:30:40,620
+يتعرض لأي خطر، ولا لا؟ لكن في بعض الأحيان، وانتوا
+
+416
+00:30:40,620 --> 00:30:44,260
+منهم من الأحيان هذه اللي بتعملوا في القطاع الطبي
+
+417
+00:30:44,260 --> 00:30:51,900
+قد تتعرضوا إلى وخز إبرة مستخدمة من مريض مصاب مثلا
+
+418
+00:30:51,900 --> 00:30:58,640
+بفيروس Hepatitis أوHIV او ناس تانين برا في الشارع
+
+419
+00:30:58,640 --> 00:31:03,440
+يتعرض لعضة من مين من كلب مسعور هذا ايش اسمه الان؟
+
+420
+00:31:03,440 --> 00:31:07,460
+exposure تمام؟ انا بدي اعمل ال vaccination مش قبل
+
+421
+00:31:07,460 --> 00:31:09,480
+بدي اعمل ال vaccination ايش بقيت لان؟ post
+
+422
+00:31:09,480 --> 00:31:12,980
+exposure اذا في ان انا pre exposure و اللي هي ال
+
+423
+00:31:12,980 --> 00:31:19,400
+post exposure most viral vaccines are given before
+
+424
+00:31:19,400 --> 00:31:24,540
+a known exposureThey are administered بـ X Boiler
+
+425
+00:31:24,540 --> 00:31:27,740
+وهذا معظم ال vaccines لبعض الأطفال اللي بناخدها
+
+426
+00:31:27,740 --> 00:31:32,680
+ضمن ال schedule المعروف هي ضمن هذا الإطار however
+
+427
+00:31:32,680 --> 00:31:38,120
+there are two vaccines the vaccine against rabies
+
+428
+00:31:38,120 --> 00:31:43,430
+and hepatitis Bthat are also effective when given
+
+429
+00:31:43,430 --> 00:31:47,090
+post exposure يبقى ال effectiveness الحقيقة لازم
+
+430
+00:31:47,090 --> 00:31:53,550
+يكون بالأساس pre exposure ومابينفعش إلا محلتين ان
+
+431
+00:31:53,550 --> 00:31:57,690
+يكون post exposure يعني مين هم اللي هم ال rabies
+
+432
+00:31:57,690 --> 00:32:00,490
+اللي قلنا ممكن ينتقل عن طريق العضة و ال hepatitis
+
+433
+00:32:00,490 --> 00:32:02,990
+B اللي ممكن ينتقل عن طريق قلنا مين اللي هو اللي
+
+434
+00:32:02,990 --> 00:32:07,310
+وخز في المستشفى تمام
+
+435
+00:32:07,310 --> 00:32:12,190
+السبب إنهم بينفع post exposureالـ Incubation
+
+436
+00:32:12,190 --> 00:32:17,790
+period للـ two diseases نوعا ما long، enough that
+
+437
+00:32:17,790 --> 00:32:21,190
+the vaccine-induced immunity can prevent the
+
+438
+00:32:21,190 --> 00:32:25,350
+disease أحكيلكوا قصة حدثت معايا و أنا طالب
+
+439
+00:32:25,350 --> 00:32:28,790
+baccalaureate في التحيات الطبية في المستشفى، كنا
+
+440
+00:32:28,790 --> 00:32:34,010
+ناخد معانا tray، tray هذه صينية، فيها كل أبواد صحف
+
+441
+00:32:34,010 --> 00:32:38,280
+الدمو كنا ناخد الصينية يجيونا request form على
+
+442
+00:32:38,280 --> 00:32:41,320
+المختبر و ناخد الصينية هذه و نروح فيها على القسم
+
+443
+00:32:41,320 --> 00:32:49,240
+اللى بنفحص اللى أنا مريض فيه بعد ما خلصت السحب في
+
+444
+00:32:49,240 --> 00:32:53,120
+trash can سلة نفايات صغيرة بنحطها في الصينية برضه
+
+445
+00:32:53,120 --> 00:32:56,880
+تمام؟ لما رميت الإبرة الإبرة طلعت واقفة مش على
+
+446
+00:32:56,880 --> 00:33:02,290
+الجهة تبعتهابدا طول جطنة صار فيه هنواخذ في المنطقة
+
+447
+00:33:02,290 --> 00:33:06,290
+يعني المريض اللي احنا عارفينش الفحص اللي كنا نفحصه
+
+448
+00:33:06,290 --> 00:33:10,330
+Hepatitis B فلقال ان المريض اصلا suspected ان عنده
+
+449
+00:33:10,330 --> 00:33:14,950
+Hepatitis B فذهبت الى المعمل وحدثت المسئولين عن
+
+450
+00:33:14,950 --> 00:33:18,650
+المختبر و قلت لهم انه واحد اتانى تلاتة طبعا صار
+
+451
+00:33:18,650 --> 00:33:22,910
+فيه قلقوقلق شديد وإذا كان .. إذا كان المريض طلع
+
+452
+00:33:22,910 --> 00:33:27,530
+positive أنا هاخد منه الآن ال post exposure اللي
+
+453
+00:33:27,530 --> 00:33:29,970
+هو ال vaccine بس بفضل الله سبحانه وتعالى طلع هو
+
+454
+00:33:29,970 --> 00:33:36,810
+negative فبالتالي لم يلزم الأمر .. مش .. مش مية
+
+455
+00:33:36,810 --> 00:33:39,830
+بالمائة بس احنا دايما بنقول في الصحة العامة مبدأ
+
+456
+00:33:39,830 --> 00:33:45,860
+اللي هو الوقاية ومبدأ الوقايةالحالة التانية اللى
+
+457
+00:33:45,860 --> 00:33:49,020
+بنعرفها مين اللى هي ال rabies و ال rabies من
+
+458
+00:33:49,020 --> 00:33:55,620
+الأمراض أيضا خطيرة جدا اللى غالبا إن لم تعالج خلال
+
+459
+00:33:55,620 --> 00:33:59,420
+فترة تلت أيام و كلمة تعالج يعني تعطى اللى هو ال
+
+460
+00:33:59,420 --> 00:34:03,360
+vaccine هاي الحالة سبعتها لل rabies غالبا المريض
+
+461
+00:34:03,360 --> 00:34:08,380
+يؤدي بيه المرض إلى الوفاة وهذا مرض خطير جدا للغاية
+
+462
+00:34:09,160 --> 00:34:13,060
+pre-exposure and post-exposure concept لازم تكون
+
+463
+00:34:13,060 --> 00:34:20,700
+واضحة بالنسبة علمي prospective prospective يعني
+
+464
+00:34:20,700 --> 00:34:27,530
+الأفاق المستقبلية في موضوع ال vaccinationالان احنا
+
+465
+00:34:27,530 --> 00:34:31,790
+بنتكلم عن disadvantages موجودة في مين في ال live و
+
+466
+00:34:31,790 --> 00:34:34,950
+disadvantages موجودة في ال killed vaccine يعني هل
+
+467
+00:34:34,950 --> 00:34:38,350
+طبعا ممكن نصل في يوم من الأيام انه نتغلب على هذه
+
+468
+00:34:38,350 --> 00:34:42,210
+ال disadvantages ولا لأ بدنا نشوف ايش العلم بيفكر
+
+469
+00:34:42,210 --> 00:34:49,450
+و العلماء ايش بيشتغلوا في هذه المرحلة القادمة الان
+
+470
+00:34:49,450 --> 00:34:55,940
+لو انا انتجت بس viral antigensViral Antigen لا
+
+471
+00:34:55,940 --> 00:35:05,160
+فيروس مضعف ولا فيروس ميت بس ال Antigen يهل ترا هحل
+
+472
+00:35:05,160 --> 00:35:09,520
+المشاكل كلها و لا هتظل بعض المشاكل انا اعتقد انه
+
+473
+00:35:09,520 --> 00:35:16,470
+هتظل بعض المشاكل ايش ضمن المشاكل ان ال Antigenتبع
+
+474
+00:35:16,470 --> 00:35:23,530
+الفيروس لن ينشط ال IGA response و لن ينشط ال cell
+
+475
+00:35:23,530 --> 00:35:28,350
+-mediated immunity يبقى هو زي مين؟ زي ال killed
+
+476
+00:35:28,350 --> 00:35:30,890
+vaccine و احنا اصلا قدّمنا هذا الكلمة، قدنا ال
+
+477
+00:35:30,890 --> 00:35:34,910
+subunit اللي ال purified من ال antigen اللي ممكن
+
+478
+00:35:34,910 --> 00:35:39,410
+ننتجها ممكن ننتجها من خلال ال cloning لبعض الجينات
+
+479
+00:35:39,410 --> 00:35:43,730
+في البكتيريا او في الخمر، تمام؟ و السر هي تنتجلنا
+
+480
+00:35:43,730 --> 00:35:44,990
+هذا ال antigen
+
+481
+00:35:48,660 --> 00:35:53,300
+طبعا ال advantage أنه مافيش nucleic acid ومافيش
+
+482
+00:35:53,300 --> 00:35:57,500
+خوف من ال reversion ومافيش خوف من الحساسية تمام؟
+
+483
+00:35:57,500 --> 00:36:01,760
+لأنه لما أنا بنمي البكتيريا وبنمي ال .. ال .. ال
+
+484
+00:36:01,760 --> 00:36:04,640
+.. ال yeast بنميها في liquid media ممكن أعمل
+
+485
+00:36:04,640 --> 00:36:08,020
+complete purification لل antigen اللي أنا بديها
+
+486
+00:36:08,020 --> 00:36:11,280
+اللي هو بتنتجه أصبحت البكتيريا أوي مافيش عندي خوف
+
+487
+00:36:11,280 --> 00:36:15,560
+من هذه القضايا كلها تمام؟ الشيء الوحيد اللي بقى
+
+488
+00:36:15,560 --> 00:36:21,210
+يعني ك a disadvantageإنه مافيش IGA ومافيش cell
+
+489
+00:36:21,210 --> 00:36:26,970
+-mediated immune زي ما حكينا does not stimulate
+
+490
+00:36:26,970 --> 00:36:33,970
+أسلوك تكسيك T cell response طيب
+
+491
+00:36:33,970 --> 00:36:43,950
+هذا ال HIV هذا ال virus تبع ال HIV طبعا ال HIV لحد
+
+492
+00:36:43,950 --> 00:36:52,310
+الآن لحد الآنلم نمتلك vaccine effective كل سنة
+
+493
+00:36:52,310 --> 00:36:55,890
+نسمع في الأخبار أنه في vaccine في ال clinical
+
+494
+00:36:55,890 --> 00:37:01,370
+trials clinical trials ولا أسمع عنه بعد ذلك بمعنى
+
+495
+00:37:01,370 --> 00:37:07,910
+أنه شماله لم ينجح في التقييمات اللي انه يكون فعال
+
+496
+00:37:07,910 --> 00:37:14,390
+لكن المحاولات مستمرة ولم تتوقف لحد هذه اللحظة
+
+497
+00:37:20,360 --> 00:37:24,920
+قدامي فيروس ممكن اخد بس ال Android نتبعته تمام؟
+
+498
+00:37:25,180 --> 00:37:29,840
+ممكن أخد بعض ال .. ال .. خلّيني أقول هم ال
+
+499
+00:37:29,840 --> 00:37:33,000
+أندجينيات تبعته أصلا مختلفة مش .. مش نوع واحد من
+
+500
+00:37:33,000 --> 00:37:34,700
+ال أندجينيات مجموعة كبيرة من ال أندجينيات لما ندوس
+
+501
+00:37:34,700 --> 00:37:39,520
+ال HIV هلاجي أنه تفاصيل ال surface تبعته كبيرة و
+
+502
+00:37:39,520 --> 00:37:43,300
+معقدة فخلّيني أتكلم و نقول إن لو حاجة بتقول إنه في
+
+503
+00:37:43,300 --> 00:37:49,180
+أكثر من فكرة إنه نعمل vaccine لـ HIV لكن لحد الآن
+
+504
+00:37:49,180 --> 00:37:55,580
+لم نصل إلى vaccine effective و ذلك جزئيا بسببإنه
+
+505
+00:37:55,580 --> 00:37:59,520
+الـ HIV بيغير من الانتجينات تبعته وبالتالي انت
+
+506
+00:37:59,520 --> 00:38:02,800
+محتاج إلى سلالات كتيرة عشان تقدر تعمل هذا ال
+
+507
+00:38:02,800 --> 00:38:06,500
+vaccine فينها اسمها DNA vaccine وهي عبارة عن
+
+508
+00:38:06,500 --> 00:38:10,960
+purified DNA encoding the appropriate viral
+
+509
+00:38:10,960 --> 00:38:13,680
+antigen يعني بناخد من الفيروس بناخد سلوك انتجينات
+
+510
+00:38:13,680 --> 00:38:18,480
+بناخد فقط اللي هي ال DNA و بنحقن ال DNA داخل الجسم
+
+511
+00:38:18,480 --> 00:38:22,200
+عبر بلازميد أو vector و ممكن في الجسم يصير
+
+512
+00:38:22,200 --> 00:38:27,160
+expressionناخد نفسنا احنا نعمل transcription و
+
+513
+00:38:27,160 --> 00:38:32,900
+translation لل DNA فننتج ال antigen تبعنا تعالى
+
+514
+00:38:32,900 --> 00:38:36,400
+الفيروس و نكوله في نفس لغة ايه؟ مانع .. بقى دلوقت
+
+515
+00:38:36,400 --> 00:38:39,180
+الجثة يعني .. يعني ..
+
+516
+00:38:42,670 --> 00:38:47,230
+مافيش تفبيقات له لسه، لكن الميزة اللي متوقعها له
+
+517
+00:38:47,230 --> 00:38:52,430
+انه يعمل ايه؟ انه يعمل Antibody Oxytoxicity Cell،
+
+518
+00:38:52,430 --> 00:38:56,110
+يعني لسه ماوصلناش ل application لهذا ال vaccine،
+
+519
+00:38:56,110 --> 00:39:01,010
+لكن هذا المتوقع انه يعمل إليسايت تحفيز لكل من ال
+
+520
+00:39:01,010 --> 00:39:05,820
+antibody و ال cell-mediated immunityهذه الفكرة
+
+521
+00:39:05,820 --> 00:39:10,920
+تبعته هذا ال ال ال جين حطناها مع بلازمد والبلازمد
+
+522
+00:39:10,920 --> 00:39:14,540
+الآن موجودة ضمن الفاكسين حقنها في الإنسان الإنسان
+
+523
+00:39:14,540 --> 00:39:19,660
+بيصير بعمل expression ل ال ال ال ال protein تبع
+
+524
+00:39:19,660 --> 00:39:23,580
+الفيروس و بيكوّنه أجسام مضادة و يبدو أنه كونه
+
+525
+00:39:23,580 --> 00:39:26,840
+بيصير فيه transcription و translation ال
+
+526
+00:39:26,840 --> 00:39:31,860
+expression للأنتجنات بيحفظ ال cytotoxic T cell في
+
+527
+00:39:31,860 --> 00:39:32,920
+هذه المرض
+
+528
+00:39:36,470 --> 00:39:40,950
+Viruses to vaccinate against other viruses هاي ال
+
+529
+00:39:40,950 --> 00:39:46,070
+concept حكيناها قبل هيك بتتذكر ال smallpox او ال
+
+530
+00:39:46,070 --> 00:39:51,950
+smallpox الوجدبي و أخوه اللي اسمه vaccinia virus
+
+531
+00:39:55,940 --> 00:40:00,080
+لما هناك فاكسينة جاء من كلمة VACA، VACA هي البقرة،
+
+532
+00:40:00,080 --> 00:40:03,060
+هدولة are the largest DNA viruses ويمكن the
+
+533
+00:40:03,060 --> 00:40:07,480
+largest viruses of all، أكبر فيروسات، وكلمة أكبر
+
+534
+00:40:07,480 --> 00:40:11,040
+فيروسات تعني إنه بيحتوى على مادة وراثية برضه حجم A
+
+535
+00:40:11,040 --> 00:40:11,880
+كبير
+
+536
+00:40:14,390 --> 00:40:19,570
+اللي انا اتخيل انه ضمن هذا الفيروس استطيع انه اشيل
+
+537
+00:40:19,570 --> 00:40:22,930
+بعض طبعا انا باخد اللي هو الأقل دراوة اللي هو
+
+538
+00:40:22,930 --> 00:40:26,830
+حاضرة من ال vaccine virus هذا ال small box خطير
+
+539
+00:40:26,830 --> 00:40:31,950
+استخدامه بيستخدم من ال vaccine virusشيلت بعض
+
+540
+00:40:31,950 --> 00:40:39,350
+الجينات منه و ركّبت بدالها جينات لانتجينات ل other
+
+541
+00:40:39,350 --> 00:40:46,530
+viruses فبصير انا عندي فيروس تمام جواته جينات قادر
+
+542
+00:40:46,530 --> 00:40:49,730
+على ال replication هذا الفكرة فكرة رائعة نجحت
+
+543
+00:40:49,730 --> 00:40:53,810
+هتعطينا يعني ال .. كل ال advantages تبع ال live
+
+544
+00:40:53,810 --> 00:40:59,870
+vaccineالتي تعمل الـ site لـ IGA production والـ
+
+545
+00:40:59,870 --> 00:41:05,440
+IGG بالاضافة للـ cell mediated immunityممكن نحط
+
+546
+00:41:05,440 --> 00:41:08,680
+هنا أربع، خمسة، ستة أو مش بس viruses، أنا بقول هنا
+
+547
+00:41:08,680 --> 00:41:12,320
+viruses to vaccinate against other viruses، لأ
+
+548
+00:41:12,320 --> 00:41:17,200
+ممكن كمان against بكتيريا، يعني نحط كمان لتكسين أو
+
+549
+00:41:17,200 --> 00:41:21,260
+toxide تبع بكتيريا ويصير ال vaccine هذا اللي هو
+
+550
+00:41:21,260 --> 00:41:24,640
+الفيروس الواحد جرعة واحدة، جرعة واحدة، من vaccine
+
+551
+00:41:24,640 --> 00:41:29,080
+واحد لعدة أمراض مختلفة، هذه كمان perspective احنا
+
+552
+00:41:29,080 --> 00:41:32,480
+متأملين انه يصير في breakthrough في السنوات
+
+553
+00:41:32,480 --> 00:41:36,180
+القادمة إن شاء اللهنفس الفكرة اللي احنا حكيناها
+
+554
+00:41:36,180 --> 00:41:45,860
+إنه ناخد من الفيروسات و ندخل في فيروس واحد طيب
+
+555
+00:41:45,860 --> 00:41:51,480
+نطلع على الأسماء تبع ال فيروسات اللي ممكن يكون لها
+
+556
+00:41:51,480 --> 00:41:57,100
+vaccine و تُعطى غالبا لأطفالميسلز هى طبعا
+
+557
+00:41:57,100 --> 00:42:00,920
+اصطنافناهم common و special situation كلمة common
+
+558
+00:42:00,920 --> 00:42:07,160
+يعني شائعة للجميع special situation في أوضاع محددة
+
+559
+00:42:07,160 --> 00:42:11,360
+مثلا انا بدى أروح على منطقة منتشر فيها مرض معين
+
+560
+00:42:11,360 --> 00:42:17,260
+كإجراء وقائي من إجراءات السفر تمام انه ناخد .. إذا
+
+561
+00:42:17,260 --> 00:42:21,280
+بنروح على السودان ناخد معانا مثلا كريمات عشان اللي
+
+562
+00:42:21,280 --> 00:42:27,950
+هم البعوضوناخد drugs للملاريا ك .. كprophylaxis لو
+
+563
+00:42:27,950 --> 00:42:30,330
+بدنا نروح الآن على اليمن تمام؟ بدنا ناخد إجراءات
+
+564
+00:42:30,330 --> 00:42:34,190
+لأن في انتشار فيها في الكورة مثلا ففي حاجة بيسموها
+
+565
+00:42:34,190 --> 00:42:38,770
+إجراءات متعلقة بالسفر لو دهبنا إلى بلدان مصاب ال
+
+566
+00:42:38,770 --> 00:42:41,970
+yellow fever بدنا ناخد هذا ال vaccine لكن مش
+
+567
+00:42:41,970 --> 00:42:45,130
+routine لو بدنا نروح الحرب بيعطونا ال antrax
+
+568
+00:42:45,130 --> 00:42:48,810
+vaccine على سبيل المثالإذن في special situation
+
+569
+00:42:48,810 --> 00:42:54,370
+ممكن ناخد فيهم، missiles, mumps, rubella، MMR
+
+570
+00:42:54,370 --> 00:42:58,030
+تمام؟ التالتة المقالة مش مقالة لهم؟ live vaccine،
+
+571
+00:42:58,030 --> 00:43:01,330
+varicella اللي هو chickenpox تمام؟ برضه live، ال
+
+572
+00:43:01,330 --> 00:43:06,350
+polio في منه اتنين قلنا live and kill، طبعا ال
+
+573
+00:43:06,350 --> 00:43:10,130
+polio قاعد بجل في العالم لدرجة إنه كتير من الدول
+
+574
+00:43:10,130 --> 00:43:15,410
+اللي قلنالكوا أعلن عن خلوها ومن ضمنها فلسطينلكن
+
+575
+00:43:15,410 --> 00:43:18,110
+ضايل بولتين بيُعزل منهم ويقولون باكستان و
+
+576
+00:43:18,110 --> 00:43:23,250
+أفغانستان لكن برضه الأعداد اللي reported قليلة جدا
+
+577
+00:43:23,250 --> 00:43:27,250
+يعني تبشر بخير إن شاء الله ففي بعض البلدان مش
+
+578
+00:43:27,250 --> 00:43:29,870
+متأكد انهم اللي وجفوه ال live و لا ال killed يعني
+
+579
+00:43:29,870 --> 00:43:32,430
+وجفوه انه ماعطلوا أطفال تبقوا هم أحد الثانيين
+
+580
+00:43:32,990 --> 00:43:36,970
+الانفلوانزا live and killed، hepatitis A killed،
+
+581
+00:43:36,970 --> 00:43:40,150
+hepatitis B subunit، subunit هذا اللي قلنا عنه
+
+582
+00:43:40,150 --> 00:43:45,410
+عبارة عن بس protein، ال rabies بنستخدم killed،
+
+583
+00:43:45,410 --> 00:43:49,290
+vaccine، ال rotavirus بنستخدم live، vaccine، ال
+
+584
+00:43:49,290 --> 00:43:53,170
+yellow fever live، Japanese encephalitis،
+
+585
+00:43:53,170 --> 00:43:58,950
+adenovirus smallpox طبعا smallpox live تمام؟ اللي
+
+586
+00:43:58,950 --> 00:44:02,230
+هو vaccinia virus
+
+587
+00:44:06,660 --> 00:44:07,180
+صحيح
+
+588
+00:44:10,450 --> 00:44:13,490
+لا إلا .. مين اللي بحكي هيك؟ انت اللي حكيت هيك أو
+
+589
+00:44:13,490 --> 00:44:16,730
+ما أحنا بنحكي غير هيك بنقول إن ال influenza إلها
+
+590
+00:44:16,730 --> 00:44:22,330
+vaccine لكن ال vaccine تبعها لأنها بتكلم عن عدد
+
+591
+00:44:22,330 --> 00:44:26,450
+محتمل من السلالات تمام مش كل السلالات اللي في
+
+592
+00:44:26,450 --> 00:44:31,070
+الدنيا بيغطيها فحتى اللي بياخد ال vaccine هذا يعني
+
+593
+00:44:31,070 --> 00:44:34,790
+ممكن يصاب لكن احتمالية إصابته بسلالة من ال
+
+594
+00:44:34,790 --> 00:44:36,750
+influenza بيكون أقل من اللي ما أخدش vaccine
+
+595
+00:44:40,660 --> 00:44:44,040
+Vaccines recommended for children aged 0 to 6
+
+596
+00:44:44,040 --> 00:44:49,780
+years طبعا
+
+597
+00:44:49,780 --> 00:44:53,140
+هنا فيه بكتيريا لفكسين ويالتي يعني نستغل الفرصة و
+
+598
+00:44:53,140 --> 00:44:58,380
+نفهم اتنين يعنى Diphtheria toxoid, tetanus toxoid,
+
+599
+00:44:58,700 --> 00:45:03,720
+cellular pertosis ويقولنا هذا اسمه D T A P طبعا
+
+600
+00:45:03,720 --> 00:45:08,160
+كان زمان اسمه D P T الanswer اسمه D T A P
+
+601
+00:45:08,720 --> 00:45:13,440
+Diphtheria, Tetanus, Acellular Pertosis هموفلس
+
+602
+00:45:13,440 --> 00:45:18,700
+انفلوانزا تايب بي او HIP Meningococcal Vaccine و
+
+603
+00:45:18,700 --> 00:45:22,140
+Neumococcal Vaccine و الحقيقة هذه الفاكسينات كلها
+
+604
+00:45:22,140 --> 00:45:27,220
+متوفرة لدينا في قطاع غزة كان اخرها الـ Neumococcal
+
+605
+00:45:27,220 --> 00:45:33,420
+في 2011 تم ادخاله الى الخدمة في قطاع غزة بينما ال
+
+606
+00:45:33,420 --> 00:45:37,190
+viral vaccinesهيباطيتس A وهنا قلنا لكم برضه
+
+607
+00:45:37,190 --> 00:45:42,970
+هيباطيتس A جديد نزل عندنا في فلسطين لأن أي بلد
+
+608
+00:45:42,970 --> 00:45:48,690
+فيها oral transmission لازم يكون فيها الهيباطيتس A
+
+609
+00:45:48,690 --> 00:45:52,270
+هيباطيتس B انفلونزا ميسلز مامبز روبيلا شفناهم قبل
+
+610
+00:45:52,270 --> 00:45:56,750
+شوية الوليو فايروس inactivated الروتا فايروس و
+
+611
+00:45:56,750 --> 00:46:02,950
+الفاريسيلا فايروس طبعا اللي بحتاج مننا الآن يعني
+
+612
+00:46:02,950 --> 00:46:04,610
+جزء جديد
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/27NHg1td15Y_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/27NHg1td15Y_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1dc94edf8dc34301612deb7287216c0cf9d6f36a
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/27NHg1td15Y_postprocess.srt
@@ -0,0 +1,1748 @@
+1
+00:00:21,890 --> 00:00:24,970
+بسم الله الرحمن الرحيم اليوم الموضوع اللي هتكون عن
+
+2
+00:00:24,970 --> 00:00:28,670
+ال genetics and gene therapy موضوع لطيف وسهل وممتع
+
+3
+00:00:28,670 --> 00:00:32,650
+وفيه تطبيقات ايضا جيدة لجنتك تستبقى الفيروس هذه
+
+4
+00:00:32,650 --> 00:00:37,150
+هنتكلم عن ال mutation هتكلم عن حاجة اسمها
+
+5
+00:00:37,150 --> 00:00:41,890
+conditional lethal mutation ايش يعني conditional
+
+6
+00:00:41,890 --> 00:00:47,930
+يعني شرطية؟طفرة شرطية إذا تحقق الشرط عملت هذه
+
+7
+00:00:47,930 --> 00:00:51,770
+الطفرة إذا لم يتحقق الشرط لم تعمل هذه الطفرة فهل
+
+8
+00:00:51,770 --> 00:00:54,550
+يمكن استغلال هذا النوع من الطفرات في عمل شيء مفيد
+
+9
+00:00:54,550 --> 00:00:58,130
+للإنسان أم لا هذا ما ستتعرف عليه إن شاء الله درسنا
+
+10
+00:00:58,130 --> 00:01:01,810
+في السابق حدث ما defective interfering particles
+
+11
+00:01:01,810 --> 00:01:05,990
+اللي هي الفيروسات الخربانة اللي عطلانة اللي مش
+
+12
+00:01:05,990 --> 00:01:11,030
+شغالة اللي بيستلزم وجود فيروس مساعد حتى يمكن أن
+
+13
+00:01:11,030 --> 00:01:14,750
+تتكاثرهل يمكن أيضا توظيف هذا الـ defective
+
+14
+00:01:14,750 --> 00:01:19,990
+interfering particle concept في عمل شيء مفيد؟ برضه
+
+15
+00:01:19,990 --> 00:01:24,410
+هذا ما سنتعرف على إن شاء الله فاندي two viruses
+
+16
+00:01:24,410 --> 00:01:29,630
+infecting one cell، they have to interactwith each
+
+17
+00:01:29,630 --> 00:01:34,430
+other داخل الخلية اتنين فيروسين مختلفين عملوا
+
+18
+00:01:34,430 --> 00:01:39,150
+infection نفس الخلية هل بالامكان انهم يتنافسوا
+
+19
+00:01:39,150 --> 00:01:44,510
+يتشاركوا يتساعدوا يتبادلوا معلومات ايضا هناك ثلاث
+
+20
+00:01:44,510 --> 00:01:49,370
+احتمالات واحد recombination اتنين complementation
+
+21
+00:01:49,370 --> 00:01:52,710
+تلاتة phenotyping mixing ايش يعني phenotyping
+
+22
+00:01:52,710 --> 00:01:58,500
+mixing؟نتخيل احنا مجموعة من الناس دخلوا في الشتاء
+
+23
+00:01:58,500 --> 00:02:03,440
+لابسين coats تمام؟ ودخلوا قاعة و بعد ساعتين بدون
+
+24
+00:02:03,440 --> 00:02:07,260
+يطلعوا، مالجين ال coats تبعونهم، عبدالرعوف أخد ال
+
+25
+00:02:07,260 --> 00:02:10,280
+coat أبو حسن، حسن أخد ال coat أبو حسين، يبقى الآن
+
+26
+00:02:10,280 --> 00:02:14,220
+اللي جوا شيء و اللي برا شيء تاني، هذا حد بيسميها
+
+27
+00:02:14,220 --> 00:02:17,520
+في ال biology phenotyping mixing و هنتعرف عليها
+
+28
+00:02:17,520 --> 00:02:22,380
+بالضبط كيف بتتم، وهل هناك فوائد منها أم لايوجد
+
+29
+00:02:22,380 --> 00:02:26,170
+أيضا فوائد؟هنتكلم ايضا عن ال gene therapy و ال
+
+30
+00:02:26,170 --> 00:02:30,490
+gene therapy هو حلم كل المرضى الذين لديهم امراض
+
+31
+00:02:30,490 --> 00:02:37,010
+وراثية ان نستبدل جيناتهم المعطلة او ال bad genes
+
+32
+00:02:37,010 --> 00:02:41,510
+with good genes هل الفيروسات يمكن ان تدخل في هذا
+
+33
+00:02:41,510 --> 00:02:45,330
+المجال و تساعد ام لا رقم اتنين recomponent
+
+34
+00:02:45,330 --> 00:02:54,890
+vaccines انا بتخيل فيروسنزعنا منه أدوات الإمراضية
+
+35
+00:02:54,890 --> 00:03:00,570
+تبعته وحطينا بدلها جينات لبكتيريا .. للتوكسين تبع
+
+36
+00:03:00,570 --> 00:03:04,010
+البكتيريا اللي اسمها Cornebacterium Diphtheria
+
+37
+00:03:04,010 --> 00:03:10,010
+ولفيروس الهيباطايتس B وA .. هكان فيروس او اتنين ..
+
+38
+00:03:10,010 --> 00:03:13,750
+A وB وده ال Influenza Virus واحد او اتنين وده ال
+
+39
+00:03:13,750 --> 00:03:17,110
+Rotavirus وكمان بكتيريا حطينا الجينات تبعت ..
+
+40
+00:03:17,110 --> 00:03:21,210
+الانتيجينات تبعتهم داخل هذا الفيروس الكبيروحققنا
+
+41
+00:03:21,210 --> 00:03:25,130
+هذا الفيروس في إنسان، الآن هذا الفيروس سمحتنا له
+
+42
+00:03:25,130 --> 00:03:29,350
+أنه يتكاثر، عطيناه الجينات اللازمة لتكاثر، لكن
+
+43
+00:03:29,350 --> 00:03:34,750
+أزلنا منه مين؟ الجينات اللازمة لإحداث المرض،
+
+44
+00:03:34,750 --> 00:03:42,290
+فتكاثر هذا الجين، الفيروس، ويصبح هناك منتجاتلل ..
+
+45
+00:03:42,290 --> 00:03:47,910
+لكل الجينات اللتي أدخلناها عامة في هذا الفيروس
+
+46
+00:03:47,910 --> 00:03:53,350
+مثلا هيطلع لنا توكسين للتتانوس توكسين للدفثيريا
+
+47
+00:03:53,350 --> 00:03:57,570
+هيطلع انتيجينات لـ Hepatitis A و LB وبالتالي الجسم
+
+48
+00:03:57,570 --> 00:04:03,470
+هيكون عايش الآن أجسام مضادة فكان يعطيت أنا فيروس
+
+49
+00:04:03,470 --> 00:04:10,780
+واحد with different antigens فطعمت المريضبشحنة
+
+50
+00:04:10,780 --> 00:04:16,140
+واحدة مجموعة من الأمراض المختلفة هذا ايضا هتكلم
+
+51
+00:04:16,140 --> 00:04:21,300
+عنه في ال gene او في ال recombinant vaccines نبدأ
+
+52
+00:04:21,300 --> 00:04:26,220
+و نتكلم عن ال mutationالـ mutation والـ effects
+
+53
+00:04:26,220 --> 00:04:30,180
+للـ replication والـ pathogenesis هل هناك أهمية
+
+54
+00:04:30,180 --> 00:04:36,360
+للطفرات على تكاثر الفيروسات؟ نعم هناك طفرات قد
+
+55
+00:04:36,360 --> 00:04:43,200
+تمنع الفيروس من التكاثر بتاتا يعني طفرة قاتلة لمن؟
+
+56
+00:04:43,200 --> 00:04:47,940
+للفيروس طيب هناك كمان طفرات تانية قد لا تكون قاتلة
+
+57
+00:04:47,940 --> 00:04:54,430
+وإنما مضاعفة للفيروس هذه ممتازة ولا لا؟ ليش؟أنا
+
+58
+00:04:54,430 --> 00:05:00,010
+عندي فيروس هو قاتل أو ممرض واستطعت إن أنا أحدث فيه
+
+59
+00:05:00,010 --> 00:05:05,070
+طفرة، هذه الطفرة لم تمنعه من التكاثر لكن منعته من
+
+60
+00:05:05,070 --> 00:05:09,790
+إحداث المرض، هذا مرشح أن يكون vaccine رائع،
+
+61
+00:05:09,790 --> 00:05:12,670
+attenuated virus
+
+62
+00:05:15,010 --> 00:05:17,390
+الـ vector في ال gene therapy حكينا عنه و ال
+
+63
+00:05:17,390 --> 00:05:20,110
+vector في ال recombinant vaccine ان ال virus can
+
+64
+00:05:20,110 --> 00:05:24,030
+act as a vector in gene therapy و كلمة vector مش
+
+65
+00:05:24,030 --> 00:05:27,250
+معناها ناقل، يعني بننقل في الجينات في ال gene
+
+66
+00:05:27,250 --> 00:05:32,010
+therapy أو ك vector لمين؟ لل recombinant vaccines
+
+67
+00:05:32,010 --> 00:05:38,660
+اللي هي اللقاحات المعدلة وراثياالميوتشن اعرفت على
+
+68
+00:05:38,660 --> 00:05:42,900
+انها any change in the sequence of DNA وكما في
+
+69
+00:05:42,900 --> 00:05:47,060
+البكتيريا وكما في المخلوقات الأخرى الفيروسات أيضا
+
+70
+00:05:47,060 --> 00:05:51,080
+مكونة من مادة وراثية هذه المادة الوراثية قد تتعرض
+
+71
+00:05:51,080 --> 00:05:57,020
+للطفرات والطفرات عبارة عن base substitution ايش
+
+72
+00:05:57,020 --> 00:06:02,680
+يعني base substitution ال T صارت G ال C صارت T
+
+73
+00:06:02,680 --> 00:06:08,870
+يعني تغيرت قاعدة بقاعدةولم تتغير قاعدة غالباً
+
+74
+00:06:08,870 --> 00:06:11,670
+بتغير one single amino acid، وممكن ما يتغيرش هذا
+
+75
+00:06:11,670 --> 00:06:16,970
+بالمناسبة، لكن على الأقل بيصير في عندي تغيير جيني،
+
+76
+00:06:16,970 --> 00:06:23,040
+لكن لو حدفت قاعدةأو أضافة قاعدة أو حذفت مجموعة من
+
+77
+00:06:23,040 --> 00:06:26,600
+القواعد و أضافت مجموعة من القواعد حاجة نسميها
+
+78
+00:06:26,600 --> 00:06:29,540
+deletion نحنا نحذف و ال addition بنسميه frame
+
+79
+00:06:29,540 --> 00:06:33,040
+shift لإنه بيصير فيه إزاحة لكل ال sequence إذا ان
+
+80
+00:06:33,040 --> 00:06:36,640
+التفرط إما base substitution إما addition أو
+
+81
+00:06:36,640 --> 00:06:39,340
+deletion و ال addition اللي كنا نعرفه هنا هو ال
+
+82
+00:06:39,340 --> 00:06:44,980
+frame shiftقلنا من أهم تطبيقات لـ mutation في الـ
+
+83
+00:06:44,980 --> 00:06:50,360
+virology هو إنتاج live attenuated viruses، فيروسات
+
+84
+00:06:50,360 --> 00:06:55,160
+مضاعفة حية، لأن هذه الـ mutants لازم تكون قد فقدت
+
+85
+00:06:55,160 --> 00:06:59,640
+قدرتها على الإمراض، بينما احتفظت بمين؟ بـ their
+
+86
+00:06:59,640 --> 00:07:03,160
+antigenicity، يعني لو دخل جسم الإنسان، جسم الإنسان
+
+87
+00:07:03,160 --> 00:07:07,660
+بدي يكوّل له أجسام مضادة، و بدون ما يكون فيه إله
+
+88
+00:07:07,660 --> 00:07:14,820
+مرضفي كمان نقطتين مهمين جدا في موضوع اللي هو ال ال
+
+89
+00:07:14,820 --> 00:07:18,680
+mutation في ال virology الأولى كانت تصريحنا صح ان
+
+90
+00:07:18,680 --> 00:07:23,700
+احنا من خلالها انتجنا vaccine من خلال إنتاج فيروس
+
+91
+00:07:23,700 --> 00:07:27,380
+غير قادر على احداث المرض بينما محتفظ بمين بال
+
+92
+00:07:27,380 --> 00:07:30,680
+antigenicity تبعته لكن اللوحة اللي أمامنا الآن
+
+93
+00:07:30,680 --> 00:07:36,390
+فيها نقطتين لصالح مين؟الأولى الـ Antigenic
+
+94
+00:07:36,390 --> 00:07:41,750
+Variation عندما تحدث طفرة أو تحدث طفرة قد ينتج عن
+
+95
+00:07:41,750 --> 00:07:46,670
+هذه الطفرة تغير في الانتيجينات وكلكم يعلم بأن رسم
+
+96
+00:07:46,670 --> 00:07:51,520
+الإنسان منعتهمرتبطة في التعرف على الانتجينات بتاع
+
+97
+00:07:51,520 --> 00:07:55,720
+المخلوقات الغازية من البكتيريا والفيروسات فعندما
+
+98
+00:07:55,720 --> 00:08:00,520
+تتغير انتجيناتها تصبح وكانها جديدة لأول مرة وتالي
+
+99
+00:08:00,520 --> 00:08:04,780
+مافيش هنا خبرة للتعامل مع هذا ال micro إذا ال
+
+100
+00:08:04,780 --> 00:08:10,100
+antigenic variation وهذا أكبر دليل وأكبر شاهد على
+
+101
+00:08:10,100 --> 00:08:14,020
+ما نراه من إصابتنا احنا كبشر بنفس المرض مرارا
+
+102
+00:08:14,020 --> 00:08:17,700
+وتكرارا مثل ال influenza ومثل اللي هو فيروس الرشد
+
+103
+00:08:19,330 --> 00:08:24,550
+وأود أن أنوز نقطة هنا في موضوع التفرات والتغيرات
+
+104
+00:08:24,550 --> 00:08:29,830
+الجينية التغير الجيني قد يكون تغير طفيف وقد يكون
+
+105
+00:08:29,830 --> 00:08:34,970
+تغير دراماتيكي بيعطيكوا مثال على تغير دراماتيكي
+
+106
+00:08:34,970 --> 00:08:41,330
+كلكوا بتسمعوا بال avian influenza اللي هي
+
+107
+00:08:41,330 --> 00:08:46,150
+influenza الطيور وبتسمعوا بالاسواعين influenza
+
+108
+00:08:46,150 --> 00:08:51,520
+اللي هي influenza الخنازيرالأولى اللى ال avian
+
+109
+00:08:51,520 --> 00:08:56,420
+نسبة انتشارها بين البشر قليلة جدا يعني انها تقريبا
+
+110
+00:08:56,420 --> 00:09:00,420
+10 سنوات تدور في الكورة الأرضية لم يتجاوز عدد
+
+111
+00:09:00,420 --> 00:09:06,020
+المصابين فيها 4000 او 5000 شخص لكن نسبة الوفيات
+
+112
+00:09:06,020 --> 00:09:12,600
+منهم فاقت ال 60% يعني من كل 100 اكتر من 60 واحد
+
+113
+00:09:12,600 --> 00:09:17,820
+بيموتوا فبيسموها highly pathogenic لكن انتقالها لا
+
+114
+00:09:17,820 --> 00:09:21,890
+يتم الا من خلال مينابناتمن خلال الطير إلى الإنسان
+
+115
+00:09:21,890 --> 00:09:27,990
+مابتنتقلش من إنسان إلى إنسان نحطها على جهة ناخد
+
+116
+00:09:27,990 --> 00:09:32,570
+الجهة التانية ال swine influenza أو influenza
+
+117
+00:09:32,570 --> 00:09:39,090
+الخنازير أصابت مليارات البشر لكن نسبة اللوفية
+
+118
+00:09:39,090 --> 00:09:43,850
+تبعتها point 005 يعني أقل من ال influenza العادية
+
+119
+00:09:43,850 --> 00:09:49,990
+لكن نسبة انتشارهاعالية الان لو جينا حسبنا حسبة
+
+120
+00:09:49,990 --> 00:09:52,610
+بعدد الوفيات حاليجة عدد الوفيات اللي ماتوا من
+
+121
+00:09:52,610 --> 00:09:57,310
+influenza الخنازير أكتر من influenza الطيور على
+
+122
+00:09:57,310 --> 00:10:02,670
+الرغم من أنه أنا 60% وانا 0.005 ليش؟ لأن العدد
+
+123
+00:10:02,670 --> 00:10:05,510
+اللي يوصيف هذا عدد كبير فبالتالي مهما كانت النسبة
+
+124
+00:10:05,510 --> 00:10:10,610
+صغيرة بيكون عدد المحصلة كبيرة الان لكم أنت تخيلوا
+
+125
+00:10:10,610 --> 00:10:13,910
+أن الفيروسين هدولة دخلوا خلية واحدة
+
+126
+00:10:16,540 --> 00:10:21,020
+وتبادلوا جينات، يعني طفرات، مش برضه في الآخر طفرة،
+
+127
+00:10:21,020 --> 00:10:25,940
+تبادلوا جينات، وطلعلنا سلالة، طلعلنا سلالة جديدة،
+
+128
+00:10:25,940 --> 00:10:29,440
+هذه السلالة لها مقدرة Influenza الخنازير على
+
+129
+00:10:29,440 --> 00:10:33,460
+الانتقال من إنسان لإنسان وانتشار بسرعة، ولها مقدرة
+
+130
+00:10:33,460 --> 00:10:38,200
+القتل العالية لدى ال Influenza تبعد الطيور، يبقى
+
+131
+00:10:38,200 --> 00:10:43,100
+حتى يصبح لدينا Virus Superمظبوط، سهل الانتقال
+
+132
+00:10:43,100 --> 00:10:47,960
+وقدرته على القتل عالية جدا، وهذه الخشية هي ليست
+
+133
+00:10:47,960 --> 00:10:53,300
+خشية نظرية، في العام 1914 كان في هناك حمّة اسمها
+
+134
+00:10:53,300 --> 00:10:57,620
+الحمّة الإسبانية، أفضل ال influenza الإسبانية،
+
+135
+00:10:57,620 --> 00:11:02,850
+وقتل فيها ما لا يقل عن أربعين مليون إنسانوفي ذاك
+
+136
+00:11:02,850 --> 00:11:06,310
+الزمن اللي هو 1914 أو 1918 مش فاكر بالظبط التاريخ
+
+137
+00:11:06,310 --> 00:11:12,270
+كان عدد الوفيات أعلى من عدد قتلى الحرب العالمية
+
+138
+00:11:12,270 --> 00:11:16,210
+الأولى والثانية و الحرب الأمريكية الفيتنامية، إذن
+
+139
+00:11:16,210 --> 00:11:20,230
+رقم مهول جدا من البشر قد يقتل من سلالة من هذا
+
+140
+00:11:20,230 --> 00:11:23,950
+النوع، إذن لما بقول Antigenic Variation قد تكون
+
+141
+00:11:23,950 --> 00:11:27,630
+بسيطةوتغير طفيف لكن قد يكون هناك أيضا تغير
+
+142
+00:11:27,630 --> 00:11:33,230
+دراماتيكي على الفيروس طبعا ما ذكرناه عن التغيير
+
+143
+00:11:33,230 --> 00:11:37,170
+الجيني الرئيسي هدرسه تحت اللي هو ال interaction
+
+144
+00:11:37,170 --> 00:11:41,550
+between two viruses تحت مصطلح اسمه reassortment
+
+145
+00:11:41,550 --> 00:11:44,910
+جزء من الجينوم هذا بنتقل للفيروس التاني والجزء
+
+146
+00:11:44,910 --> 00:11:49,930
+التاني بحلم حله للأولى النقطة التانية اللي صالح
+
+147
+00:11:49,930 --> 00:11:54,510
+الفيروس اللي هي drug resistant mutantاحنا ملقنا
+
+148
+00:11:54,510 --> 00:11:58,930
+الدنيا صراخا على ان البكتيريا ستتقام من المضادات
+
+149
+00:11:58,930 --> 00:12:03,130
+الحيوية لكن هل ترى الفيروسات عندها المقدرة اللي هي
+
+150
+00:12:03,130 --> 00:12:07,390
+كائنات بيبقوا عنها غير حية صح؟ هل لديها المقدرة
+
+151
+00:12:07,390 --> 00:12:11,150
+على انها تشكل resistance لعقاقير او مضادات
+
+152
+00:12:11,150 --> 00:12:16,310
+الفيروسات؟ نعم لديها وأكبر دي على ذلك هو فيروس ال
+
+153
+00:12:16,310 --> 00:12:22,870
+aidsيعني أصبح مقاوم لكثير من عقاقير الـAnti
+
+154
+00:12:22,870 --> 00:12:26,310
+-retroviral drugs اللي هي عقاقير مضادة لفيروس
+
+155
+00:12:26,310 --> 00:12:32,210
+الـAIDS إذن Miss 10 في صالح مين؟ في صالح الفيروس
+
+156
+00:12:32,210 --> 00:12:35,370
+ميلي ميوتاشين الأولى أنه بيعمل Antigenic Variation
+
+157
+00:12:35,370 --> 00:12:41,850
+رقم اتنين بيعمل Drug Resistance نجي لمصطلح اللي
+
+158
+00:12:41,850 --> 00:12:45,550
+احنا وعدناكم بالتعرف عليه باسم Conditional Lethal
+
+159
+00:12:45,550 --> 00:12:51,960
+Mutation وهيImmutation بتشتغل في ضرف، بنسميه
+
+160
+00:12:51,960 --> 00:12:56,640
+permissive، الضرف الذي يسمح، permissive، تمام؟ لكن
+
+161
+00:12:56,640 --> 00:13:02,230
+تفشل في العمل علىالتعبير عن هذا الجين أو عن هذه
+
+162
+00:13:02,230 --> 00:13:05,910
+الطفرة في حالة يسميها restrictive إذا في عندي
+
+163
+00:13:05,910 --> 00:13:09,570
+permissive و في عندي restrictive ال permissive
+
+164
+00:13:09,570 --> 00:13:13,030
+اللي يسمح بالتعبير عنه و ال restrictive هو اللي
+
+165
+00:13:13,030 --> 00:13:17,790
+يمنع التعبير عنه إذا في عندي ضارفين هناخد مثل عليه
+
+166
+00:13:17,790 --> 00:13:21,770
+مثلا temperature sensitive conditional lethal
+
+167
+00:13:21,770 --> 00:13:26,720
+mutant طفرات حساسة لمين بالحرارةالـ low
+
+168
+00:13:26,720 --> 00:13:31,340
+temperature بصير exhibition للجين و ال high
+
+169
+00:13:31,340 --> 00:13:36,940
+temperature بصير عدم exhibition للجين طب هل ترى هل
+
+170
+00:13:36,940 --> 00:13:45,140
+هناك فائدة خطوط بأذهانكم الآن من هذه التفرط؟ يعني
+
+171
+00:13:45,140 --> 00:13:53,080
+مثلا العلماء إيش عملوا؟ عملوا vaccine لل influenza
+
+172
+00:13:55,240 --> 00:14:02,100
+بنرشه في القنف فال influenza ال mutant هذي at low
+
+173
+00:14:02,100 --> 00:14:06,760
+temperature it will be expressed الجين العادي
+
+174
+00:14:06,760 --> 00:14:12,420
+بيصير ال expression و بتتكاثر بشكل جيد تمام؟ لكن
+
+175
+00:14:12,420 --> 00:14:17,480
+لو نزلت على الجسم من تحت على ال lungs يعني تمام؟
+
+176
+00:14:17,480 --> 00:14:21,780
+درجة حمامها أعلى بتمنع اللي هو ال expression
+
+177
+00:14:21,780 --> 00:14:26,030
+وبتالي يبطل الفيروس يتكاثرإذا أنا استخدمت vaccine
+
+178
+00:14:26,030 --> 00:14:30,810
+آمن، vaccine آمن، بين عالمين، على إن هذا ال
+
+179
+00:14:30,810 --> 00:14:35,890
+vaccine بيحتوي على سلالة فيها طفراسا منها
+
+180
+00:14:35,890 --> 00:14:38,990
+conditional lethal mutation، لكن اللي .. اللي
+
+181
+00:14:38,990 --> 00:14:42,510
+أمامنا على اللوحة موضوع مختلف، اللي هو فيروس تاني
+
+182
+00:14:42,510 --> 00:14:46,670
+اسمه Raw's Sarcoma Virus، ال Raw's Sarcoma وكلمة
+
+183
+00:14:46,670 --> 00:14:51,260
+Sarcoma يعني سلطان، تمام؟فيروس بيسبب ساركومة وخاصة
+
+184
+00:14:51,260 --> 00:14:55,440
+في الفئران can transform cell to malignancy بيحول
+
+185
+00:14:55,440 --> 00:14:58,680
+الخلايا إلى خلايا سرطانية على ال permissive
+
+186
+00:14:58,680 --> 00:15:02,960
+temperature اللي هي قداش 37 درجة مئوية لو مرفعها
+
+187
+00:15:02,960 --> 00:15:06,900
+لداشت في حالات الوسط إلى 41 بيضلوا يتكاثر لكن
+
+188
+00:15:06,900 --> 00:15:12,270
+بيعملش ساركومة ولا malignancyإذن برضه فيه تطبيقات
+
+189
+00:15:12,270 --> 00:15:16,730
+ممكن محتملة لهذه الظاهرة اللي إيشت منها كمان مرة
+
+190
+00:15:16,730 --> 00:15:21,350
+conditional lethal mutation وخدنا نموذج عليها اللي
+
+191
+00:15:21,350 --> 00:15:25,010
+هو ال temperature sensitive ل two viruses الفيروس
+
+192
+00:15:25,010 --> 00:15:28,510
+الأول اللي وجدانا هو الراوسر كومة والفيروس التاني
+
+193
+00:15:28,510 --> 00:15:32,210
+اللي هو ال influenza virus اللي كنا استخدمناه في
+
+194
+00:15:32,210 --> 00:15:33,750
+مين في الفكسينة
+
+195
+00:15:36,320 --> 00:15:40,320
+الـ Defective Interfering Particle، إذا بتذكروا،
+
+196
+00:15:40,320 --> 00:15:46,860
+لما شرحنا الـ Basic Virology، تحدثنا عن Virus-like
+
+197
+00:15:46,860 --> 00:15:50,980
+Particles، وكان أول واحدة منهم اللي هي Defective
+
+198
+00:15:50,980 --> 00:15:55,060
+Interfering Particle، وكنا هي عبارة عن فيروسلا
+
+199
+00:15:55,060 --> 00:16:00,500
+يمتلك القدرة على التكاثر بذاته ويحتاج helper virus
+
+200
+00:16:00,500 --> 00:16:04,860
+المساعدة اعطيكم مثال بيتعلق بوقعكم الأكاديمي لما
+
+201
+00:16:04,860 --> 00:16:09,000
+بناخد امتحان احنا واحنا جاعدين جانب بعض انا بحل
+
+202
+00:16:09,000 --> 00:16:14,940
+الخمس اسئلة وضل علي مين السادس بدون السادس هذا مش
+
+203
+00:16:14,940 --> 00:16:21,260
+هننجح تمام فبناخده من مين؟من المساعد؟ من المساعد؟
+
+204
+00:16:21,260 --> 00:16:25,720
+شخص آخر عنده هذا أو عنده إجابة هذا السؤال؟ تماروه
+
+205
+00:16:25,720 --> 00:16:29,900
+هذي في الامتحانات؟ طبعا كلكم قد رأينا، أكيد، نعم،
+
+206
+00:16:29,900 --> 00:16:35,160
+الآن في كمان حاجة تانية ممكن تكون لطيفة، إنه
+
+207
+00:16:35,160 --> 00:16:40,730
+اتنين، واحد عنده سؤال، اتنين مش محلول،وواحد تاني
+
+208
+00:16:40,730 --> 00:16:44,350
+عنده سؤال أربعة مش محلول فبتبادله أبو أربعة بعطيه
+
+209
+00:16:44,350 --> 00:16:47,150
+سؤال لإتنين و أبو اتنين بعطيه سؤال و أبو اتنين
+
+210
+00:16:47,150 --> 00:16:51,210
+بعطيه للتاني الجواب تبعه وبتاني بيصير فيه نوع من
+
+211
+00:16:51,210 --> 00:16:56,950
+ال complementation ف ال defective interfering
+
+212
+00:16:56,950 --> 00:17:03,010
+particles هي particles غير قادرة على التكاثر
+
+213
+00:17:03,010 --> 00:17:09,920
+بذاتها لابد من وجود فيروس مساعدوأشهر مثال ضربناه
+
+214
+00:17:09,920 --> 00:17:14,420
+هو Hepatitis D و Hepatitis B
+
+215
+00:17:17,420 --> 00:17:22,360
+والـ B هو المساعد يعني في خلال في إنتاج protein
+
+216
+00:17:22,360 --> 00:17:27,240
+معين لـ D بوفر له يمين B فبالتالي بيجرد كثر لذلك
+
+217
+00:17:27,240 --> 00:17:32,300
+قلنا إذا وجدنا D عند مريض فمؤكد لازم يكون فيه B
+
+218
+00:17:32,300 --> 00:17:39,760
+مستحيل مايكونش فيه B وللألم اتنين يعني وجودهم فيفي
+
+219
+00:17:39,760 --> 00:17:44,960
+مريض واحد بيؤدي الى complication أسوأ مما لو كان
+
+220
+00:17:44,960 --> 00:17:52,440
+ال B طبعا لوحده مستحيل يكون ال D لوحده فالاقول ان
+
+221
+00:17:52,440 --> 00:17:55,920
+احنا لما كون two viruses infecting one cell بقولنا
+
+222
+00:17:55,920 --> 00:17:59,080
+ممكن يصير فينا recombination وكلمة recombination
+
+223
+00:17:59,080 --> 00:18:04,720
+يعني جين مع جين يتبادلوا بعمل crossing over بقفل
+
+224
+00:18:04,720 --> 00:18:07,510
+الكرموزوماتأو complementation وكلمة
+
+225
+00:18:07,510 --> 00:18:10,250
+complementation بالضبط زي ما ذكرنا مثال انتحان
+
+226
+00:18:10,250 --> 00:18:14,030
+واحد قاعد طالب تاني سؤال و ال phenotyping mixing
+
+227
+00:18:14,030 --> 00:18:16,930
+اللي هو السؤال .. ال .. ال .. ال .. ال مثال اللي
+
+228
+00:18:16,930 --> 00:18:22,810
+قولنا أحد الناس أخد معطف الآخر فقد يبدو للآخرين
+
+229
+00:18:22,810 --> 00:18:28,530
+أنه شخص آخر لكن من جوا هو originally نفس الشخص طيب
+
+230
+00:18:28,530 --> 00:18:35,950
+معروف أن ال DNA virusesبيحدث فيها عملية الـ
+
+231
+00:18:35,950 --> 00:18:40,970
+Recombination لكن الـ RNA viruses الاعتقاد السائد
+
+232
+00:18:40,970 --> 00:18:44,650
+انه اذا كان فيه Recombination في الـ RNA viruses
+
+233
+00:18:44,650 --> 00:18:51,210
+فهي نادرة جدا او لا تحدث على الإطلاق لكن بدناش
+
+234
+00:18:51,210 --> 00:18:55,030
+ننسى ان ال influenza virus اللي كنا متحدث عنه قبل
+
+235
+00:18:55,030 --> 00:19:00,490
+قليل هو RNA virus ولا يحدث Recombination بالمفهوم
+
+236
+00:19:00,490 --> 00:19:05,450
+Recombination وانما يحدث تبادلقطع واش سميناها
+
+237
+00:19:05,450 --> 00:19:12,010
+المصطلح سميناها reassortment reassortment وال
+
+238
+00:19:12,010 --> 00:19:16,090
+reassortment المقصود فيها هو تبادل قطع من ال
+
+239
+00:19:16,090 --> 00:19:20,590
+genome تبع فيروس influenza type X و فيروس
+
+240
+00:19:20,590 --> 00:19:25,190
+influenza type B طب تعالى نطلع هل هذا حقيقي وبيحدث
+
+241
+00:19:25,190 --> 00:19:32,350
+في الواقع ولا لأ يقال ونظريها دى ان الفلاح الصيني
+
+242
+00:19:33,060 --> 00:19:37,500
+اللي هو بيعمل في الحقول في الصين في الحضيرة تبعته
+
+243
+00:19:37,500 --> 00:19:41,220
+بيكون فيه حصان فيه بقرة وممكن يكون فيه جمل كمان
+
+244
+00:19:41,220 --> 00:19:47,780
+وكم من خنزير اكرمكم الله ودجاج وبط وطيور اخرى اوز
+
+245
+00:19:47,780 --> 00:19:51,200
+وغيره وغيرته بالاضافة الى الطيور المهاجرة اللى
+
+246
+00:19:51,200 --> 00:19:56,420
+بيبتدي تشارك هذه الحيانات الولئم تبعتها لحظة هذه
+
+247
+00:19:56,420 --> 00:20:02,120
+المجموعة من المخلوقاتإن في من ال influenza viruses
+
+248
+00:20:02,120 --> 00:20:08,500
+قد يصيب الحصان والخنزير أكرمكم الله ولكن لا يصيب
+
+249
+00:20:08,500 --> 00:20:12,380
+الإنسان وفي منها يصيب الإنسان ويصيب الخنزير
+
+250
+00:20:12,380 --> 00:20:15,860
+فالخنزير اللي أنا لحظة عامل مشترك بين two viruses
+
+251
+00:20:16,600 --> 00:20:21,000
+لو انتقلت سلالة من الإنسان للخنزير وفي نفس الوقت
+
+252
+00:20:21,000 --> 00:20:26,140
+من الحصار إلى الخنزير قد يحدث ما تحدثنا عنه من ما
+
+253
+00:20:26,140 --> 00:20:31,980
+يسمى الـ reassortment وهي بالمناسبة المتهمة الأول
+
+254
+00:20:31,980 --> 00:20:35,900
+لهذه العملية إنها هي اللي بتغير ال influenza تغيير
+
+255
+00:20:35,900 --> 00:20:39,320
+جذري اللي احنا كنا خايفين منه زي ما ذكرنا قبل قليل
+
+256
+00:20:39,320 --> 00:20:41,780
+influenza الطيور و influenza الخنازير
+
+257
+00:20:45,270 --> 00:20:48,170
+الصورة اللي أمامنا بتوضح اللي هو النموذج اللي أنا
+
+258
+00:20:48,170 --> 00:20:53,010
+شرحته قبل قليل هي highly pathogenic avian strain
+
+259
+00:20:53,010 --> 00:20:56,670
+وكلمة avian strain هي السلالة تبع الطيور بينما هنا
+
+260
+00:20:56,670 --> 00:21:01,470
+ال human strain لاحظوا أنه ممثلين الجينم هنا بلون
+
+261
+00:21:01,470 --> 00:21:07,570
+و هنا بلون أخر عندما صار فيه يعني التقاء للفيروسين
+
+262
+00:21:07,570 --> 00:21:14,970
+وفي نفس الخلية أصبح هناك لديناجينات من كل من
+
+263
+00:21:14,970 --> 00:21:21,310
+السلالتين و أصبح لدينا أيضا لحظة في الخارج تمام
+
+264
+00:21:21,310 --> 00:21:26,910
+ربما مايصيح تغيير جذري لأن هنا أخضر أخضر الزهري هو
+
+265
+00:21:26,910 --> 00:21:31,650
+نفس اللون الزهري بمعنى ال expression هنا تبع ال
+
+266
+00:21:31,650 --> 00:21:36,630
+quote ما اتغير لكن مين اتغير الجينات فقد يكتسب
+
+267
+00:21:36,630 --> 00:21:44,750
+الفيروس هنا صفات جديدةميزات جديدة و قد لا تكون
+
+268
+00:21:44,750 --> 00:21:49,690
+صفات جديدة ولا ميزات جديدة بمعنى أنه فيروس جديد
+
+269
+00:21:49,690 --> 00:21:55,470
+صحيح لكن ليس له أي قيمة يعني لم يحصل على صفات تؤهل
+
+270
+00:21:55,470 --> 00:22:00,370
+أن يكون أفضل من ذي قبل فيموت وتذهب سلالة وتندثر
+
+271
+00:22:00,370 --> 00:22:05,530
+لكن هذه العملية مستمرةوبالتالي احتمالية انه كل كام
+
+272
+00:22:05,530 --> 00:22:10,230
+سنة يطلعنا سلالة ناجحة هي احتمالية واردة وهذا
+
+273
+00:22:10,230 --> 00:22:14,150
+بالفعل ما يحدث كل سبع الى عشر سنوات بيطلعنا سلالة
+
+274
+00:22:14,150 --> 00:22:18,970
+جديدة من ال influence جديدة خالص تمام؟ و بتعمل
+
+275
+00:22:18,970 --> 00:22:22,750
+epidemic او pandemic وكلمة pandemic يعني انتشار
+
+276
+00:22:22,750 --> 00:22:25,940
+عالمي لهذا الوباءطبعا بالنسبة لـ Recombination
+
+277
+00:22:25,940 --> 00:22:31,320
+لحظة انا عندي على خطها A بكبتل و انا ا بكبتل و انا
+
+278
+00:22:31,320 --> 00:22:33,700
+ا بكبتل و انا ا بكبتل و انا ا بكبتل و انا ا بكبتل
+
+279
+00:22:33,700 --> 00:22:33,840
+و انا ا بكبتل و انا ا بكبتل و انا ا بكبتل و انا ا
+
+280
+00:22:33,840 --> 00:22:34,580
+بكبتل و انا ا بكبتل و انا ا بكبتل و انا ا بكبتل و
+
+281
+00:22:34,580 --> 00:22:36,240
+انا ا بكبتل و انا ا بكبتل و انا ا بكبتل و انا ا
+
+282
+00:22:36,240 --> 00:22:40,980
+بكبتل و انا ا بكبتل و انا ا بكبتل و انا ا بكبتل و
+
+283
+00:22:40,980 --> 00:22:47,540
+انا ا بكبتل و انا ا بكبتل
+
+284
+00:22:47,540 --> 00:22:51,600
+و انا االـ Complementation يعني الحقيقة برضه
+
+285
+00:22:51,600 --> 00:22:54,240
+ذكرناها أكتر مرة لكن لا بأس أنه نتطلع عليه في
+
+286
+00:22:54,240 --> 00:22:59,580
+المثال Antivirus A و Virus B لما لحالهم بيكونوا
+
+287
+00:22:59,580 --> 00:23:03,340
+موجودين No Progeny كلمة No Progeny يعني غير قادرين
+
+288
+00:23:03,340 --> 00:23:07,240
+على التكاثر، مافيش سلالة لهم، لكن لما Virus A and
+
+289
+00:23:07,240 --> 00:23:13,890
+B have beenTogether in a medium they both produce
+
+290
+00:23:13,890 --> 00:23:17,610
+virus A and virus B يعني بتاع ليه ساعدوا بعض أو
+
+291
+00:23:17,610 --> 00:23:23,670
+عملوا complementation لبعض مش دايما العملية بتكون
+
+292
+00:23:23,670 --> 00:23:27,990
+أنه التنين محتاجين بعض ممكن واحد يحتاج التاني
+
+293
+00:23:28,840 --> 00:23:32,880
+فالتاني زي الـ zeddy واللي قول بيه، التاني بنسميه
+
+294
+00:23:32,880 --> 00:23:36,300
+helper والأولاني بنسميه defective، لكن لما يكونوا
+
+295
+00:23:36,300 --> 00:23:40,880
+التانين defective فواحد helper للآخر، كل واحد
+
+296
+00:23:40,880 --> 00:23:44,180
+بيكون helper والأولاني بيسميها complementation،
+
+297
+00:23:44,180 --> 00:23:49,210
+واحد بيكمل الآخرهي الـ Phenotyping Mixing اللي
+
+298
+00:23:49,210 --> 00:23:53,670
+قولنا عنه ان واحد بيلبس رداء الآخر تمام؟ تعالوا
+
+299
+00:23:53,670 --> 00:23:57,730
+تطلعوا على هاي B و هاي A شوفولي A كويس طلعوا عليها
+
+300
+00:23:57,730 --> 00:24:01,610
+عشان نعرف الشكل الخارجي إليه عبارة عن دوائر
+
+301
+00:24:01,610 --> 00:24:05,630
+الانتجينات بينما هنا مثلثات كلا هما أصاب نفس
+
+302
+00:24:05,630 --> 00:24:11,690
+الخلية ما هي الاحتمالات أن يخرج هذا الفيروس من هذه
+
+303
+00:24:11,690 --> 00:24:16,020
+الخلية؟ واحد الاحتمال الأول طلعوا على Aنفس ال
+
+304
+00:24:16,020 --> 00:24:19,600
+parent نفس اللي هو يعني أخد ال quote تبعه و أخد
+
+305
+00:24:19,600 --> 00:24:25,580
+المادة الوراثية تبعته، التاني أخد المادة الوراثية
+
+306
+00:24:25,580 --> 00:24:31,790
+تبعته و أخد من ال quoteGlycoproteins من A و
+
+307
+00:24:31,790 --> 00:24:37,370
+Glycoproteins من B و واحد أخد من A المادة الوراثية
+
+308
+00:24:37,370 --> 00:24:43,330
+و أخد totally quote من وين؟ من B و نفس اللي حصل في
+
+309
+00:24:43,330 --> 00:24:50,380
+A بيحصل في B معكوسةيبقى فينا احتمالات ان يطلع
+
+310
+00:24:50,380 --> 00:24:55,840
+original زي الوالد زي ال parent virus او ان يكون
+
+311
+00:24:55,840 --> 00:25:03,620
+hybrid وماياخد gene الوالد وماياخد quote من الاخر
+
+312
+00:25:03,620 --> 00:25:07,720
+تمام؟ الان لو كلهم هدولة أخدناهم وعملناهم
+
+313
+00:25:07,720 --> 00:25:12,680
+infection لخلايا جديدة كلهم بيطلعوا من؟الـ
+
+314
+00:25:12,680 --> 00:25:18,420
+original virus لأن المادة الوراثية لما تدخل داخل
+
+315
+00:25:18,420 --> 00:25:23,340
+خلية أخرى سوف تصنع فقط من مكونات الفيروس الأبض
+
+316
+00:25:23,340 --> 00:25:28,000
+وبالتالي ترجع كما هي طيب ما الفائدة اللذي جناها
+
+317
+00:25:28,000 --> 00:25:37,800
+الفيروس الآن من الحصول على coat تمام؟ مش إله أحكي
+
+318
+00:25:43,000 --> 00:25:46,260
+طب مسكين لو كان نصيبه عاد ان الجسم اللي دخل فيه
+
+319
+00:25:46,260 --> 00:25:49,120
+فيه له antibody لل .. لل .. ال antigen اللي ..
+
+320
+00:25:49,120 --> 00:25:53,500
+اللي دخل فيه بتذكروا
+
+321
+00:25:53,500 --> 00:25:59,440
+كلمة host specificity و organ specificity؟ الآن
+
+322
+00:25:59,440 --> 00:26:04,100
+اللي زي هذا الفيروس عنده specificity ل tissue معين
+
+323
+00:26:04,100 --> 00:26:09,280
+صح و لأ بس هذازادت ال specificity صار عنده لانوعين
+
+324
+00:26:09,280 --> 00:26:14,440
+هذا صار عنده لانوع جديد ماكانش أساسا إله
+
+325
+00:26:14,440 --> 00:26:19,000
+specificity لكن كمان مرة بدخل داخل ال host
+
+326
+00:26:19,000 --> 00:26:23,980
+وبيتكاثر تمام وبيطلع زي ال original و التالي هي
+
+327
+00:26:23,980 --> 00:26:29,760
+فقط transient bypass كلمة transient يعني موقعة
+
+328
+00:26:29,760 --> 00:26:34,380
+bypass اللي هو تخطي ال host specificity أو ال
+
+329
+00:26:34,380 --> 00:26:41,250
+organ specificityطبعا أي فيروس بيحتوي على مادة
+
+330
+00:26:41,250 --> 00:26:48,170
+وراثية أو غلاف مش إله، تمام؟ بنسميه pseudo-type أو
+
+331
+00:26:48,170 --> 00:26:51,710
+pseudo-virus، فأظن يمر معانا الـpseudo-virus في ال
+
+332
+00:26:51,710 --> 00:26:54,970
+animal viruses لما قلنا إنه الفيروس من برا فيروس
+
+333
+00:26:54,970 --> 00:26:57,670
+ومن جوا مادة وراثية من وين؟ من ال horse اللي
+
+334
+00:26:57,670 --> 00:26:59,630
+سميناها برضه pseudo-variant
+
+335
+00:27:02,450 --> 00:27:04,650
+طيب نيجي للـ gene therapy و ال recombinant
+
+336
+00:27:04,650 --> 00:27:07,070
+vaccines اللي هنختم فيهم محاضرتنا اليوم ان شاء
+
+337
+00:27:07,070 --> 00:27:10,530
+الله قولنا ال viruses بيستخدموا ك vector إما to
+
+338
+00:27:10,530 --> 00:27:14,470
+deliver new functional genes to the patient with
+
+339
+00:27:14,470 --> 00:27:17,450
+genetic disease وبين جثين سببين العملية دي إيه؟
+
+340
+00:27:17,450 --> 00:27:22,410
+gene therapy ال gene therapy قد يستخدم وسائل
+
+341
+00:27:22,410 --> 00:27:26,850
+متعددة لكن أنا الآن بتكلم عن ال viruses كوسيلة
+
+342
+00:27:26,850 --> 00:27:33,180
+لنقل الجينة تمام؟ لماذا ال viruses؟أو بالأحرى
+
+343
+00:27:33,180 --> 00:27:36,860
+لماذا ال retro viruses؟ وأرجو أن يكون عندكم فكرة
+
+344
+00:27:36,860 --> 00:27:41,160
+لأن المحاضرة السابقة احنا ختمنا ال replication of
+
+345
+00:27:41,160 --> 00:27:46,340
+viruses وختمناها بموضوع اسمه lysogeny وال lysogeny
+
+346
+00:27:46,340 --> 00:27:51,560
+ايش معناه؟ integrationلأ المادة الوراثية تبعها
+
+347
+00:27:51,560 --> 00:27:55,980
+الفيروس في ال host genome وال retroviruses اللي
+
+348
+00:27:55,980 --> 00:28:00,240
+ينتمي إلى ال aids تمام بالمناسبة هي خير دليل أو
+
+349
+00:28:00,240 --> 00:28:03,580
+خير مثال على مين على فيروسات عندها المقدرة لتعمل
+
+350
+00:28:03,580 --> 00:28:08,020
+integration لل genome تبعها، إذن نتخيل مع بعض
+
+351
+00:28:08,020 --> 00:28:13,980
+التالت جبناالفيروس تبع ال retrovirus جزجصنا منه
+
+352
+00:28:13,980 --> 00:28:17,740
+الانزيمات أو عفوا الجينات اللي مش لازمة وكلمة مش
+
+353
+00:28:17,740 --> 00:28:23,540
+لازمة مش معناها مش لازمة وانما هي المواد دي ال
+
+354
+00:28:23,540 --> 00:28:28,960
+disease و بالمناسبة كمان شيلنا معاها one gene
+
+355
+00:28:28,960 --> 00:28:35,100
+أساسي للتكاثر مابناشيها تتكاثر احنا الا بمعرفتنا
+
+356
+00:28:35,100 --> 00:28:42,260
+احنالما شيلنا جين مسئول عن التكاثر تبع الفيروس
+
+357
+00:28:42,260 --> 00:28:46,360
+أصبحت defective viruses صح ولا مش صح؟ يبجي عشان
+
+358
+00:28:46,360 --> 00:28:50,680
+تتكاثر ايش بدها؟ بدها helper، تمام؟ يبجي عشان تخيل
+
+359
+00:28:50,680 --> 00:28:55,880
+الفيروس تبع retro virus غير قادر على التكاثر، لكن
+
+360
+00:28:55,880 --> 00:29:03,420
+ضفنا له يا بنات الجين الصحيح اللي بننقله للمريض
+
+361
+00:29:03,420 --> 00:29:08,290
+اللي عنده خلل في هذا الجينوجيبنا ال .. كان فيروس
+
+362
+00:29:08,290 --> 00:29:12,010
+.. انا عملت فيروس واحد انا، أخدته، هل فيروس واحد
+
+363
+00:29:12,010 --> 00:29:15,470
+هتكفي ان ارحل المريض فيه، يصليح المريض؟ الفيروس
+
+364
+00:29:15,470 --> 00:29:19,230
+الواحد هتدخل خلية واحدة، فلازم اعمله عملية ايه؟
+
+365
+00:29:19,230 --> 00:29:22,310
+تكاثر، بس مانيش التكاثر يكون جوا الإنسان، مانيش
+
+366
+00:29:22,310 --> 00:29:26,050
+يكون التكاثر وين؟ برا الإنسان، فبروح بصمم cell
+
+367
+00:29:26,050 --> 00:29:30,240
+culture، خلاياالجين فاكرين اللي شيلته من ال .. من
+
+368
+00:29:30,240 --> 00:29:34,020
+ال .. من الفيروس؟ شيلته عشان مايتكثرش، هذا الجين
+
+369
+00:29:34,020 --> 00:29:39,200
+بحقنه في الخلايا اللي بدى نمي عليها الفيروس، ايش
+
+370
+00:29:39,200 --> 00:29:43,920
+صارت الخلايا الآن؟ كأنها helper cells، سموها
+
+371
+00:29:43,920 --> 00:29:48,200
+helper cells وبنمي الفيروس عليها، بتكاثر الفيروس،
+
+372
+00:29:48,200 --> 00:29:52,760
+لكن محد ما اخد الفيروس منها واحقنه في الإنسان، لن
+
+373
+00:29:52,760 --> 00:29:57,510
+يتكاثرفقط بيدخلوا في مين؟ في الخلايا وبعمل
+
+374
+00:29:57,510 --> 00:30:02,070
+integration وبيدخل الجينوم تبعه إلى داخل الخلايا
+
+375
+00:30:02,070 --> 00:30:06,510
+والجينوم تبعه اللي أنا نجزه منه مين؟ الجين الصحيح
+
+376
+00:30:06,510 --> 00:30:11,310
+اللي أنا نقلته ومثال عليها أشهر مثال حد اسمه ADA
+
+377
+00:30:11,310 --> 00:30:15,900
+geneوهذا الـ ADE جين كان من .. يعني خلّيني نقول من
+
+378
+00:30:15,900 --> 00:30:19,140
+الأمثلة الناجحة على استخدام ال retroviruses في
+
+379
+00:30:19,140 --> 00:30:22,840
+عملية ال .. ال gene therapy وانا اعتقد ان ال gene
+
+380
+00:30:22,840 --> 00:30:27,560
+therapy ما زال بتروح up and down لكن الأمال معقودة
+
+381
+00:30:27,560 --> 00:30:31,710
+على الفيروسات في أن تكون هي الناقللأن الفيروسات
+
+382
+00:30:31,710 --> 00:30:36,030
+تضمن الوصول إلى عدد كبير من مين من الخلايا وبنضمن
+
+383
+00:30:36,030 --> 00:30:40,690
+من خلالها integration لل gene داخل الجينوم مش
+
+384
+00:30:40,690 --> 00:30:45,090
+بالله معلج في النواء أو في الcytoplasm وقد يتكسر
+
+385
+00:30:45,090 --> 00:30:49,850
+بعد فترة أو عجيزة هذا مثال على الكلمات اللي
+
+386
+00:30:49,850 --> 00:30:53,870
+حكيناهم بالنسبة للفيروس وشيلنا وحطينا في cell
+
+387
+00:30:53,870 --> 00:30:56,990
+culture cell culture معناه هذا cell culture helper
+
+388
+00:30:56,990 --> 00:31:03,600
+cell cultureيعني كومبناند فاكسينز ايضا المرشح
+
+389
+00:31:03,600 --> 00:31:08,440
+الرئيسي لها الفاكسينيا فيروس الفاكسينيا بتذكركوا
+
+390
+00:31:08,440 --> 00:31:11,840
+كلمة vaccination ولا لا؟ ايش يعني فاكسيناشن؟
+
+391
+00:31:11,840 --> 00:31:17,740
+تطييم، تلقيح، مظبوط؟ تطييم عارفين ايش معد؟ vaca
+
+392
+00:31:17,740 --> 00:31:21,900
+باللاتيني مع أنها بقرة طب مش علاقة vaca و
+
+393
+00:31:21,900 --> 00:31:26,980
+vaccination و vaccineلمّا Edward Jenner اللي هو
+
+394
+00:31:26,980 --> 00:31:30,760
+اللي بيعتبره مؤسس علم التطايم أو ال vaccination
+
+395
+00:31:30,760 --> 00:31:34,920
+الحديث، لاحظ ملاحظة أن النساء اللي بيحلبنا البقر
+
+396
+00:31:34,920 --> 00:31:39,640
+يصابنا بنوع من الجدري يحميهن من مين؟ من الجدري
+
+397
+00:31:39,640 --> 00:31:44,020
+الخطير اللي هو ال smallpoxفصار ياخد من الجدري تبع
+
+398
+00:31:44,020 --> 00:31:48,160
+ال .. ال .. ال .. ال cow box اللي هي ال VACA وسموا
+
+399
+00:31:48,160 --> 00:31:51,760
+الفيروس لها Vaccina من VACA وسموا العملية
+
+400
+00:31:51,760 --> 00:31:56,480
+Vaccination عملية ايه؟ Vaccination ميزات هذا
+
+401
+00:31:56,480 --> 00:32:00,920
+الفيروس ان حجمه كبير ولا تتذكروا في أول محاضرة لما
+
+402
+00:32:00,920 --> 00:32:05,220
+استعرضنا بعض بعض صور للفيروسات ورناكوا صورة ال ..
+
+403
+00:32:05,220 --> 00:32:09,670
+ال .. ال بي كورنا فيروسووريناكوا صورة ال Ebola
+
+404
+00:32:09,670 --> 00:32:13,330
+virus وجنبه ال Box viruses، ال Box viruses تعتبر
+
+405
+00:32:13,330 --> 00:32:19,470
+حجمها كبير، لأن حجمه كبير، المادة اللي بقيت بقتها
+
+406
+00:32:19,470 --> 00:32:26,970
+كبيرة، فبتعطينا فرصة أكبر أنه نجطع و نركب فيها كم
+
+407
+00:32:26,970 --> 00:32:32,430
+كبير منهامن الـ Antigen .. من الجينات المسئولة عن
+
+408
+00:32:32,430 --> 00:32:37,610
+إنتاج Antigenات أنا بدي أستخدمها لتطييم البشر،
+
+409
+00:32:37,610 --> 00:32:42,310
+تمام؟ فبنجسجس منها كميات كهية طبعاً للفيروس، بنحط
+
+410
+00:32:42,310 --> 00:32:47,770
+مع بعض الجينات المسئولة عن الـ Antigenات واحد أو
+
+411
+00:32:47,770 --> 00:32:52,050
+أكثر، تمام؟ واحد أو أكثر، لكن بدلا من أن أنا صرت
+
+412
+00:32:52,050 --> 00:32:56,870
+..نستخدم فيروس كبير لماذا لا أقوم بحقنة واحدة
+
+413
+00:32:56,870 --> 00:33:00,490
+بفيروس واحد تطييب إنسان لعشرة أمراض على سبيل
+
+414
+00:33:00,490 --> 00:33:04,350
+المثال لعشرة أمراض بدل ما ياخد كل يوم تطييب أنا
+
+415
+00:33:04,350 --> 00:33:10,690
+بعطيه تطييب واحد فقط لغاية طبعا في زمن ثورة
+
+416
+00:33:10,690 --> 00:33:15,470
+الهندسة الولاياتية في سبعينيات القرن الماضي كان في
+
+417
+00:33:15,470 --> 00:33:22,680
+أحلام كثيرة مثلا ننتج حليب حليبمعدل وراثيا يحتوي
+
+418
+00:33:22,680 --> 00:33:27,960
+على الانتجينات تبعت كثير من الأمراض كويس وبالتالي
+
+419
+00:33:27,960 --> 00:33:31,920
+يشربوا الطفل ويتطعم او موز يأكل موزة او تفاحة
+
+420
+00:33:31,920 --> 00:33:37,000
+تحتوي على لكن هذه كان يعني ينقصها الواقعية لأنه
+
+421
+00:33:37,000 --> 00:33:40,240
+بدأ عبر الفم غالبا هذه الانتجينات بيصير لها
+
+422
+00:33:40,240 --> 00:33:44,060
+digestion وهضم وما بتصلش للدم وال immune system ما
+
+423
+00:33:44,060 --> 00:33:49,600
+بتعرف عليها ألخصوحضرتنا اليوم تكلمنا فيها عن
+
+424
+00:33:49,600 --> 00:33:53,800
+مجموعة من العناصر تكلمنا عن الـ mutationواتكلمنا
+
+425
+00:33:53,800 --> 00:34:00,220
+عن أثارها الإيجابي لنا من خلال عمل طفرات في
+
+426
+00:34:00,220 --> 00:34:06,160
+الفيروسات وجعلها ضعيفة حية يمكن استخدامها كفاكسين
+
+427
+00:34:06,160 --> 00:34:11,600
+وتحدثنا عن الطفرة الجيدة من وجه نظر الفيروس أعطته
+
+428
+00:34:11,600 --> 00:34:16,000
+Antigenic Variation أعطته قدرة على أن يقاوم من
+
+429
+00:34:16,000 --> 00:34:23,890
+العقاقير لل Antiviral Drugsعندما يلتقي فيروسان في
+
+430
+00:34:23,890 --> 00:34:29,530
+خلية واحدة تحدثنا عن ال reassortment او اللي هي
+
+431
+00:34:29,530 --> 00:34:35,070
+سمناها recombination واتكلمنا عن اللي هو ال
+
+432
+00:34:35,070 --> 00:34:39,190
+complementation انه فيروس يكمل الاخر والتالتة اللي
+
+433
+00:34:39,190 --> 00:34:42,810
+هو ال phenotype mixing بعد انتقلنا الى ال gene
+
+434
+00:34:42,810 --> 00:34:46,940
+therapy واتكلمنا عنالـ Retroviruses واتكلمنا عن
+
+435
+00:34:46,940 --> 00:34:52,480
+ركمل الفاكسين وتحدثنا عن الفاكسينيا فيروس وبهذا
+
+436
+00:34:52,480 --> 00:34:54,620
+نكون انتهينا من هذه المحاضرة ان شاء الله نكمل
+
+437
+00:34:54,620 --> 00:34:56,340
+المحاضرة القادمة ان شاء الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/27NHg1td15Y_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/27NHg1td15Y_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..55426766aca4e27163ff90665e0e27cdc5b1ffd0
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/27NHg1td15Y_raw.json
@@ -0,0 +1 @@
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Cornebacterium Diphtheria ولفيروس الهيباطايتس B وA .. هكان فيروس او اتنين .. 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الجيدة من وجه نظر الفيروس أعطته Antigenic Variation أعطته قدرة على أن يقاوم من العقاقير لل Antiviral Drugs", "tokens": [2407, 9307, 4117, 19528, 8315, 18871, 5551, 12984, 9640, 11296, 33688, 1829, 7435, 16758, 1829, 5296, 8315, 9154, 16490, 1211, 6027, 6225, 42213, 23032, 5172, 2288, 9307, 8978, 27188, 13546, 41779, 9307, 49610, 30241, 11296, 48812, 3615, 33911, 3660, 11331, 1829, 3660, 7251, 43020, 44713, 9778, 3215, 10943, 11296, 9122, 5172, 995, 4117, 3794, 9957, 34683, 24401, 12984, 8315, 18871, 41950, 5172, 25720, 25724, 25708, 3660, 9154, 49610, 3224, 8717, 19913, 2288, 27188, 13546, 41779, 5551, 3615, 9566, 47395, 5130, 3213, 299, 32511, 399, 5551, 3615, 9566, 47395, 12174, 3215, 25720, 15844, 14739, 7251, 4587, 995, 20498, 9154, 18863, 4587, 995, 4587, 13546, 24976, 5130, 592, 35083, 2491, 14950], "avg_logprob": -0.21889203881675548, "compression_ratio": 1.6244725738396624, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2033.22, "end": 2033.8, "word": "واتكلمنا", "probability": 0.851953125}, {"start": 2033.8, "end": 2033.96, "word": " عن", "probability": 0.99365234375}, {"start": 2033.96, "end": 2034.54, "word": " أثارها", "probability": 0.77825927734375}, {"start": 2034.54, "end": 2035.64, "word": " الإيجابي", "probability": 0.92685546875}, {"start": 2035.64, "end": 2036.1, "word": " لنا", "probability": 0.78759765625}, {"start": 2036.1, "end": 2036.78, "word": " من", "probability": 0.94091796875}, {"start": 2036.78, "end": 2037.24, "word": " خلال", "probability": 0.9951171875}, {"start": 2037.24, "end": 2038.46, "word": " عمل", "probability": 0.98583984375}, {"start": 2038.46, "end": 2039.84, "word": " طفرات", "probability": 0.9215087890625}, {"start": 2039.84, "end": 2040.22, "word": " في", "probability": 0.935546875}, {"start": 2040.22, "end": 2041.02, "word": " الفيروسات", "probability": 0.9541015625}, {"start": 2041.02, "end": 2042.06, "word": " وجعلها", "probability": 0.9347330729166666}, {"start": 2042.06, "end": 2043.0, "word": " ضعيفة", "probability": 0.994140625}, {"start": 2043.0, "end": 2044.12, "word": " حية", "probability": 0.6946614583333334}, {"start": 2044.12, "end": 2044.66, "word": " يمكن", "probability": 0.9794921875}, {"start": 2044.66, "end": 2045.46, "word": " استخدامها", "probability": 0.9720703125}, {"start": 2045.46, "end": 2046.16, "word": " كفاكسين", "probability": 0.7912190755208334}, {"start": 2046.16, "end": 2047.44, "word": " وتحدثنا", "probability": 0.8331298828125}, {"start": 2047.44, "end": 2047.82, "word": " عن", "probability": 0.99267578125}, {"start": 2047.82, "end": 2048.8, "word": " الطفرة", "probability": 0.9514973958333334}, {"start": 2048.8, "end": 2049.56, "word": " الجيدة", "probability": 0.958984375}, {"start": 2049.56, "end": 2049.64, "word": " من", "probability": 0.9365234375}, {"start": 2049.64, "end": 2049.76, "word": " وجه", "probability": 0.550262451171875}, {"start": 2049.76, "end": 2049.96, "word": " نظر", "probability": 0.8159993489583334}, {"start": 2049.96, "end": 2050.5, "word": " الفيروس", "probability": 0.9845377604166666}, {"start": 2050.5, "end": 2051.6, "word": " أعطته", "probability": 0.8740234375}, {"start": 2051.6, "end": 2052.56, "word": " Antigenic", "probability": 0.722412109375}, {"start": 2052.56, "end": 2053.3, "word": " Variation", "probability": 0.7919921875}, {"start": 2053.3, "end": 2054.1, "word": " أعطته", "probability": 0.908203125}, {"start": 2054.1, "end": 2054.54, "word": " قدرة", "probability": 0.9270833333333334}, {"start": 2054.54, "end": 2054.86, "word": " على", "probability": 0.9052734375}, {"start": 2054.86, "end": 2055.14, "word": " أن", "probability": 0.350341796875}, {"start": 2055.14, "end": 2055.66, "word": " يقاوم", "probability": 0.967041015625}, {"start": 2055.66, "end": 2056.0, "word": " من", "probability": 0.94384765625}, {"start": 2056.0, "end": 2057.64, "word": " العقاقير", "probability": 0.7222412109375}, {"start": 2057.64, "end": 2058.32, "word": " لل", "probability": 0.456787109375}, {"start": 2058.32, "end": 2059.06, "word": " Antiviral", "probability": 0.7069091796875}, {"start": 2059.06, "end": 2059.76, "word": " Drugs", "probability": 0.6361083984375}], "temperature": 1.0}, {"id": 86, "seek": 208455, "start": 2061.99, "end": 2084.55, "text": "عندما يلتقي فيروسان في خلية واحدة تحدثنا عن ال reassortment او اللي هي سمناها recombination واتكلمنا عن اللي هو ال complementation انه فيروس يكمل الاخر والتالتة اللي هو ال phenotype mixing بعد انتقلنا الى ال gene therapy واتكلمنا عن", "tokens": [3615, 41260, 15042, 7251, 1211, 2655, 38436, 8978, 32887, 3794, 7649, 8978, 16490, 1211, 10632, 36764, 24401, 3660, 6055, 24401, 12984, 8315, 18871, 2423, 19486, 477, 518, 1975, 2407, 13672, 1829, 39896, 8608, 2304, 8315, 11296, 850, 3548, 2486, 4032, 9307, 4117, 19528, 8315, 18871, 13672, 1829, 31439, 2423, 17103, 399, 16472, 3224, 8978, 32887, 3794, 7251, 24793, 1211, 2423, 47283, 2288, 16070, 2655, 6027, 2655, 3660, 13672, 1829, 31439, 2423, 7279, 13108, 11983, 39182, 16472, 2655, 4587, 1211, 8315, 2423, 7578, 2423, 12186, 9492, 4032, 9307, 4117, 19528, 8315, 18871], "avg_logprob": -0.1971807049020477, "compression_ratio": 1.7560975609756098, "no_speech_prob": 5.364418029785156e-07, "words": [{"start": 2061.99, "end": 2062.79, "word": "عندما", "probability": 0.8289388020833334}, {"start": 2062.79, "end": 2063.21, "word": " يلتقي", "probability": 0.982421875}, {"start": 2063.21, "end": 2063.75, "word": " فيروسان", "probability": 0.94189453125}, {"start": 2063.75, "end": 2063.89, "word": " في", "probability": 0.93505859375}, {"start": 2063.89, "end": 2064.23, "word": " خلية", "probability": 0.97998046875}, {"start": 2064.23, "end": 2064.85, "word": " واحدة", "probability": 0.9860026041666666}, {"start": 2064.85, "end": 2065.67, "word": " تحدثنا", "probability": 0.9000244140625}, {"start": 2065.67, "end": 2066.09, "word": " عن", "probability": 0.982421875}, {"start": 2066.09, "end": 2066.77, "word": " ال", "probability": 0.93603515625}, {"start": 2066.77, "end": 2067.97, "word": " reassortment", "probability": 0.7220052083333334}, {"start": 2067.97, "end": 2068.43, "word": " او", "probability": 0.65771484375}, {"start": 2068.43, "end": 2069.37, "word": " اللي", "probability": 0.5631103515625}, {"start": 2069.37, "end": 2069.53, "word": " هي", "probability": 0.51953125}, {"start": 2069.53, "end": 2070.27, "word": " سمناها", "probability": 0.74365234375}, {"start": 2070.27, "end": 2072.21, "word": " recombination", "probability": 0.7149658203125}, {"start": 2072.21, "end": 2073.29, "word": " واتكلمنا", "probability": 0.82119140625}, {"start": 2073.29, "end": 2073.57, "word": " عن", "probability": 0.9814453125}, {"start": 2073.57, "end": 2074.23, "word": " اللي", "probability": 0.9169921875}, {"start": 2074.23, "end": 2074.51, "word": " هو", "probability": 0.9619140625}, {"start": 2074.51, "end": 2075.07, "word": " ال", "probability": 0.9677734375}, {"start": 2075.07, "end": 2075.87, "word": " complementation", "probability": 0.746826171875}, {"start": 2075.87, "end": 2076.23, "word": " انه", "probability": 0.59375}, {"start": 2076.23, "end": 2076.55, "word": " فيروس", "probability": 0.9676106770833334}, {"start": 2076.55, "end": 2077.03, "word": " يكمل", "probability": 0.99169921875}, {"start": 2077.03, "end": 2077.77, "word": " الاخر", "probability": 0.789306640625}, {"start": 2077.77, "end": 2078.93, "word": " والتالتة", "probability": 0.837548828125}, {"start": 2078.93, "end": 2079.19, "word": " اللي", "probability": 0.9208984375}, {"start": 2079.19, "end": 2079.31, "word": " هو", "probability": 0.98095703125}, {"start": 2079.31, "end": 2079.41, "word": " ال", "probability": 0.794921875}, {"start": 2079.41, "end": 2080.01, "word": " phenotype", "probability": 0.961669921875}, {"start": 2080.01, "end": 2080.73, "word": " mixing", "probability": 0.87109375}, {"start": 2080.73, "end": 2081.39, "word": " بعد", "probability": 0.374267578125}, {"start": 2081.39, "end": 2081.93, "word": " انتقلنا", "probability": 0.882177734375}, {"start": 2081.93, "end": 2082.23, "word": " الى", "probability": 0.7880859375}, {"start": 2082.23, "end": 2082.47, "word": " ال", "probability": 0.98046875}, {"start": 2082.47, "end": 2082.81, "word": " gene", "probability": 0.88525390625}, {"start": 2082.81, "end": 2083.35, "word": " therapy", "probability": 0.93017578125}, {"start": 2083.35, "end": 2084.31, "word": " واتكلمنا", "probability": 0.96826171875}, {"start": 2084.31, "end": 2084.55, "word": " عن", "probability": 0.98388671875}], "temperature": 1.0}, {"id": 87, "seek": 209634, "start": 2084.82, "end": 2096.34, "text": "الـ Retroviruses واتكلمنا عن ركمل الفاكسين وتحدثنا عن الفاكسينيا فيروس وبهذا نكون انتهينا من هذه المحاضرة ان شاء الله نكمل المحاضرة القادمة ان شاء الله", "tokens": [6027, 39184, 11495, 24088, 347, 8355, 4032, 9307, 4117, 19528, 8315, 18871, 12602, 24793, 1211, 27188, 995, 4117, 3794, 9957, 34683, 24401, 12984, 8315, 18871, 27188, 995, 4117, 3794, 9957, 25528, 8978, 32887, 3794, 46599, 3224, 15730, 8717, 30544, 16472, 47395, 1829, 8315, 9154, 29538, 9673, 5016, 46958, 25720, 16472, 13412, 16606, 21984, 8717, 24793, 1211, 9673, 5016, 46958, 25720, 25062, 18513, 46007, 16472, 13412, 16606, 21984], "avg_logprob": -0.21576286194955602, "compression_ratio": 1.7161290322580645, "no_speech_prob": 2.682209014892578e-06, "words": [{"start": 2084.82, "end": 2085.12, "word": "الـ", "probability": 0.470703125}, {"start": 2085.12, "end": 2085.8, "word": " Retroviruses", "probability": 0.7635498046875}, {"start": 2085.8, "end": 2086.54, "word": " واتكلمنا", "probability": 0.746923828125}, {"start": 2086.54, "end": 2086.94, "word": " عن", "probability": 0.9921875}, {"start": 2086.94, "end": 2087.74, "word": " ركمل", "probability": 0.4365234375}, {"start": 2087.74, "end": 2088.28, "word": " الفاكسين", "probability": 0.87392578125}, {"start": 2088.28, "end": 2089.32, "word": " وتحدثنا", "probability": 0.82781982421875}, {"start": 2089.32, "end": 2090.0, "word": " عن", "probability": 0.99267578125}, {"start": 2090.0, "end": 2091.16, "word": " الفاكسينيا", "probability": 0.8875732421875}, {"start": 2091.16, "end": 2091.84, "word": " فيروس", "probability": 0.793212890625}, {"start": 2091.84, "end": 2092.48, "word": " وبهذا", "probability": 0.6581217447916666}, {"start": 2092.48, "end": 2092.8, "word": " نكون", "probability": 0.67919921875}, {"start": 2092.8, "end": 2093.16, "word": " انتهينا", "probability": 0.943603515625}, {"start": 2093.16, "end": 2093.3, "word": " من", "probability": 0.970703125}, {"start": 2093.3, "end": 2093.5, "word": " هذه", "probability": 0.90771484375}, {"start": 2093.5, "end": 2093.98, "word": " المحاضرة", "probability": 0.98974609375}, {"start": 2093.98, "end": 2094.1, "word": " ان", "probability": 0.6494140625}, {"start": 2094.1, "end": 2094.22, "word": " شاء", "probability": 0.98583984375}, {"start": 2094.22, "end": 2094.24, "word": " الله", "probability": 0.92724609375}, {"start": 2094.24, "end": 2094.62, "word": " نكمل", "probability": 0.9850260416666666}, {"start": 2094.62, "end": 2095.36, "word": " المحاضرة", "probability": 0.9915771484375}, {"start": 2095.36, "end": 2095.78, "word": " القادمة", "probability": 0.9923502604166666}, {"start": 2095.78, "end": 2096.02, "word": " ان", "probability": 0.8125}, {"start": 2096.02, "end": 2096.26, "word": " شاء", "probability": 0.993896484375}, {"start": 2096.26, "end": 2096.34, "word": " الله", "probability": 0.93603515625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2096.576125, "duration_after_vad": 2012.2518749999945}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/5JmKrldRkA4_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/5JmKrldRkA4_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7ba67088381fdca7d0dd5dcddad97456d1e5253b
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/5JmKrldRkA4_postprocess.srt
@@ -0,0 +1,2220 @@
+1
+00:00:20,890 --> 00:00:24,030
+بسم الله الرحمن الرحيم الموضوع الجديد اليوم اللي
+
+2
+00:00:24,030 --> 00:00:29,510
+هو ال viral pathogenesis كيف لذاك الفيروس الصغير
+
+3
+00:00:29,510 --> 00:00:33,230
+الذي لايمتلك من مقومات الحياة إلا قدرة على التكاثر
+
+4
+00:00:33,230 --> 00:00:38,470
+كيف له أن يحدث أمراض قد تتراوح من أمراض بسيطة
+
+5
+00:00:38,470 --> 00:00:42,350
+وسهلة إلى أمراض خطيرة جدا هذا مثلا اتعرف عليه ان
+
+6
+00:00:42,350 --> 00:00:48,640
+شاء الله في محاضرتنا اليوم viral pathogenesisويمكن
+
+7
+00:00:48,640 --> 00:00:52,640
+لنا أن نستعرض ال pathogenesis للفيروس بطريقة
+
+8
+00:00:52,640 --> 00:00:57,740
+تانية، الطريقة الأولى من خلال رؤيتنا لما يحدث في
+
+9
+00:00:57,740 --> 00:01:03,250
+الخلية المصابة أو من خلال رؤيتنا للعائل ككلإذا إما
+
+10
+00:01:03,250 --> 00:01:07,290
+على مستوى الخلية أو على مستوى العائل فحنشوف إن شاء
+
+11
+00:01:07,290 --> 00:01:12,930
+الله في ال infected cell إن هناك أربع احتمالات لأي
+
+12
+00:01:12,930 --> 00:01:17,210
+خلية تصاب بفيروس الاحتمال الأول هو موت الخلية
+
+13
+00:01:17,210 --> 00:01:24,130
+deathوالاحتمال الثاني هو ان تتحد مجموعة من الخلايا
+
+14
+00:01:24,130 --> 00:01:28,670
+لتكون ما يسمى او ما يُعرف بـ Multi-Nucleated Giant
+
+15
+00:01:28,670 --> 00:01:35,110
+Cell ويمكن لنا تخيل مجموعة من الخلايا لها أنوية
+
+16
+00:01:35,110 --> 00:01:42,050
+أصيبت إحداها أو كلهم بالفيروس يمكن للفيروس أن يزيل
+
+17
+00:01:42,050 --> 00:01:46,190
+هذه الفواصل لتصبح
+
+18
+00:01:48,270 --> 00:01:54,750
+خلية واحدة ضخمة giant ذات أنوية متعددة نسميها
+
+19
+00:01:54,750 --> 00:01:59,070
+multinucleated giant cell أما الخيار الثالث أو
+
+20
+00:01:59,070 --> 00:02:03,710
+الاحتمال الثالث وهو تحول الخلية إلى خلية سرطانية
+
+21
+00:02:03,710 --> 00:02:06,490
+واحنا بنعرف انها مجموعة من الفيروسات نسميها
+
+22
+00:02:06,490 --> 00:02:13,300
+oncovirusesOr Fusion Or Transformation To
+
+23
+00:02:13,300 --> 00:02:17,840
+Malignancy الإحتمال الرابع اللى يظهر عليها أي
+
+24
+00:02:17,840 --> 00:02:24,440
+إشارات خارجية كلمة apparent يعني ظاهرية تمام أو
+
+25
+00:02:24,440 --> 00:02:28,180
+حتى ال functional change يعني مش شايفين فيها تغير
+
+26
+00:02:28,180 --> 00:02:33,540
+وظيفة لهذه الخلايا كيف
+
+27
+00:02:33,540 --> 00:02:40,500
+لخلية أن تموت عندما تصاب ب فيروس؟أقوى احتمال وهو
+
+28
+00:02:40,500 --> 00:02:43,800
+الاحتمال اللى تم دراسته او حصلنا على evidence انه
+
+29
+00:02:43,800 --> 00:02:48,140
+حقيقي موجود وهو ايقاف تصنيع ال macro molecules،
+
+30
+00:02:48,140 --> 00:02:50,720
+ايش يعني macro molecules؟ يعني proteins، يعني
+
+31
+00:02:50,720 --> 00:02:54,180
+carbohydrates، يعني DNA، يعني lipids، هذه هي ال
+
+32
+00:02:54,180 --> 00:03:00,150
+macro moleculesإذا من من هذه ال macro molecules
+
+33
+00:03:00,150 --> 00:03:04,310
+التي يستطيع الفيروس أن يستهدفها؟ الحقيقة نعم لا
+
+34
+00:03:04,310 --> 00:03:07,850
+يستهدف إلا ال protein لماذا يستهدف ال protein؟ لأن
+
+35
+00:03:07,850 --> 00:03:11,390
+ال protein عبارة عن process translation وهو تخصصه
+
+36
+00:03:11,390 --> 00:03:14,850
+أنه يعمل transcription and translation انت فاكرين؟
+
+37
+00:03:14,850 --> 00:03:18,410
+early transcription and translation طيب هل يمكن
+
+38
+00:03:18,410 --> 00:03:25,170
+الفيروس أن يوقفالـ Cellular Protein Synthesis دون
+
+39
+00:03:25,170 --> 00:03:29,790
+ما يقاف لـ Protein Synthesis الخاص فيه نعم يمكنه
+
+40
+00:03:29,790 --> 00:03:35,210
+ذلك لكن قبل ما نتعرف على كيف يمكنه ذلك دعونا نتعرف
+
+41
+00:03:35,210 --> 00:03:38,610
+على ال consequences لـ Protein Synthesis
+
+42
+00:03:38,610 --> 00:03:42,150
+Inhibition يعني اتوقف لـ Protein Synthesis في
+
+43
+00:03:42,150 --> 00:03:47,470
+خلينا ما الذي سيحدث تذكروا ان كل الانزينات في
+
+44
+00:03:47,470 --> 00:03:52,440
+الخلية هي Proteinاتإذا توقفت الانزيمات، اللي هي
+
+45
+00:03:52,440 --> 00:03:58,020
+البروتينات، عن الإنتاج، عن العمل، عن أداء وظائفها،
+
+46
+00:03:58,020 --> 00:04:02,140
+فانا بتوقع حتى ال DNA يبطل يصير له synthesis، لكن
+
+47
+00:04:02,140 --> 00:04:08,080
+بالأساستوقف ال DNA مش كنتيجة أولية وانما كنتيجة
+
+48
+00:04:08,080 --> 00:04:12,120
+ثانوية لتصنيع من ال protein توقف ال protein فتوقف
+
+49
+00:04:12,120 --> 00:04:18,280
+ال DNA نموذج تم دراسته وعرفناه هو ال poliovirus ال
+
+50
+00:04:18,280 --> 00:04:21,780
+poliovirus بيعمل inactivation لل protein synthesis
+
+51
+00:04:21,780 --> 00:04:25,180
+من خلال inactivation of initiation factor اللي هو
+
+52
+00:04:25,180 --> 00:04:29,680
+ال IF هذا ال initiation factor ضروري لنا لل
+
+53
+00:04:29,680 --> 00:04:36,090
+cellular protein synthesis تبعنا لكنهل ضروري ل ال
+
+54
+00:04:36,090 --> 00:04:39,430
+.. ال viral mRNA؟ تعالوا نطلع، إيش بيقولنا؟ Polio
+
+55
+00:04:39,430 --> 00:04:44,370
+virus، mRNA has a special ribosome initiating site
+
+56
+00:04:44,370 --> 00:04:49,870
+that does not require أو bypass، يعني ممكن يتجاوز
+
+57
+00:04:49,870 --> 00:04:53,450
+ال initiation factor، إذا ال initiation factor صار
+
+58
+00:04:53,450 --> 00:04:57,800
+مطلوب للسيليور و مش مطلوب للفيروسوبالتالي إذا
+
+59
+00:04:57,800 --> 00:05:00,300
+وقفنا ال initiation factor سيتوقف ال protein
+
+60
+00:05:00,300 --> 00:05:04,320
+synthesis في ال host ولن يتوقف في من؟ في ال virus
+
+61
+00:05:04,320 --> 00:05:08,300
+إذا فكرة ذكية على قتل الخلايا من خلال استهداف ال
+
+62
+00:05:08,300 --> 00:05:12,820
+protein synthesis ال
+
+63
+00:05:12,820 --> 00:05:17,360
+infected cells في الفيروسات قد نرع فيها ما يسمى أو
+
+64
+00:05:17,360 --> 00:05:20,120
+يعرف بال inclusion bodies احنا ممكن تطرحنا هذا
+
+65
+00:05:20,120 --> 00:05:24,820
+الكلام لما اتكلمنا عن ال cytopathic effect في مرات
+
+66
+00:05:24,820 --> 00:05:28,690
+سابقةالـ Inclusion Bodies هذي عبارة عن إما Viral
+
+67
+00:05:28,690 --> 00:05:35,850
+Particles أو Viral Proteins يعني الفيروس كامل جوا
+
+68
+00:05:35,850 --> 00:05:39,350
+الخلية بنعتبره Inclusion أو أجزاء من الفيروس
+
+69
+00:05:39,350 --> 00:05:43,510
+بنعتبرها أيضا Inclusions ممكن هذه الـ Inclusion
+
+70
+00:05:43,510 --> 00:05:48,130
+تكون إما في الدنوية وسميها Intranuclear وممكن تكون
+
+71
+00:05:48,130 --> 00:05:51,970
+في الـCytoplasm وسميها Intracytoplasmic ليش
+
+72
+00:05:51,970 --> 00:05:56,950
+Intranuclear؟ لأن في بعض الفيروساتفي النواء كل ال
+
+73
+00:05:56,950 --> 00:06:00,370
+DNA viruses اتفقنا انها بتروح على النواء ما عدا من
+
+74
+00:06:00,370 --> 00:06:04,630
+ال box virus وفي جزء من ال RNA viruses برضه بروح
+
+75
+00:06:04,630 --> 00:06:09,210
+على من؟ على النواء، اذا هناك viruses بتتكاثر في
+
+76
+00:06:09,210 --> 00:06:12,590
+النواء فلو أنا أخدت صورة تحت ال microscope لخلية
+
+77
+00:06:12,590 --> 00:06:16,490
+مصابة وفيها فيروسات في النواء، هنقدر نشوف ال
+
+78
+00:06:16,490 --> 00:06:20,000
+inclusion body أو على الأقل بعض منهاأما
+
+79
+00:06:20,000 --> 00:06:23,840
+Intranuclear أو Intra قلناها Cytoplasmic من أشهر
+
+80
+00:06:23,840 --> 00:06:27,140
+ال inclusion bodies على الإطلاق في ال Virology
+
+81
+00:06:27,140 --> 00:06:31,640
+حاجة مسميها Negri bodiesوالـ Negribodies is
+
+82
+00:06:31,640 --> 00:06:36,180
+diagnostic of rabies يعني لو أخذنا من دماغ كلب
+
+83
+00:06:36,180 --> 00:06:41,600
+مصاب أو من أنسجة خفاش مصاب تمام أو حتى من إنسان
+
+84
+00:06:41,600 --> 00:06:47,440
+مصاب من دماغه لما توفى وعملنا الوسمير وصبغناه
+
+85
+00:06:47,440 --> 00:06:51,740
+بنشوف intracytoplasmic هو اللي موجود الآن في الـ
+
+86
+00:06:51,740 --> 00:06:54,800
+cytoplasm intracytoplasmic inclusion بسميها
+
+87
+00:06:54,800 --> 00:06:59,350
+Negribodiesووجود الـ Negribody دلالة مؤكدة على
+
+88
+00:06:59,350 --> 00:07:02,790
+وجود الـ Ravis Virus، لاحظوا الآن إن استخدمت هذه
+
+89
+00:07:02,790 --> 00:07:08,060
+الإشارة إلى Diagnosisفي كمان شغلة اللي هي الـ Owls
+
+90
+00:07:08,060 --> 00:07:10,640
+Eye عينان البومة اللي حكينالكم عنهم سابقاً و
+
+91
+00:07:10,640 --> 00:07:13,740
+هنوريكوا صورة لهم الآن ان شاء الله ال Owls Eye is
+
+92
+00:07:13,740 --> 00:07:16,740
+included in the nucleus of the cytomegalovirus
+
+93
+00:07:16,740 --> 00:07:20,140
+-infected cell CMV اللي واحد أعضاء ال herpes
+
+94
+00:07:20,140 --> 00:07:24,740
+viruses تمام؟ إذا عمل infection في خلية دائما هذه
+
+95
+00:07:24,740 --> 00:07:29,420
+الخلية لو صبغناها هنشوف فيها الشكل المميز لما يسمى
+
+96
+00:07:29,420 --> 00:07:35,300
+بال Owls Eye في أنالـ missiles اللى درسناها
+
+97
+00:07:35,300 --> 00:07:40,280
+المحاضرة الماضية اللى هى الحصبة اللى هى تابعة لمين
+
+98
+00:07:40,280 --> 00:07:44,260
+للبراميكسى viruses و ال herpes viruses كلا هما
+
+99
+00:07:44,260 --> 00:07:47,260
+بيعمل اللى رسم اللى رسمناها اللى سمناها multi
+
+100
+00:07:47,260 --> 00:07:51,380
+-nucleated giant cell و الآن هنشوف بعض الصور اللى
+
+101
+00:07:51,380 --> 00:07:54,120
+هم هدى نجري bodies اللى مشارلها بالسهم إذا
+
+102
+00:07:54,120 --> 00:08:01,290
+بتلاحظوا عندى ال نجري body هذا تمامالـ neuron cell
+
+103
+00:08:01,290 --> 00:08:05,630
+وهذه هي النواة التابعة للـ neuron cell هذا مؤشر
+
+104
+00:08:05,630 --> 00:08:11,570
+أكيد على أن هذا الشخص مصاب بمين بالريبز أعتقد أن
+
+105
+00:08:11,570 --> 00:08:15,350
+الصورة هناك صورة حقيقية لبومة وبعينين بومة بالأحرى
+
+106
+00:08:15,350 --> 00:08:18,290
+عشان ترى بس جدش جميلين يعني بعض الناس بتشيأوا من
+
+107
+00:08:18,290 --> 00:08:23,560
+البوم يعنيواطلعوا الصورة اللى موجودة ان في الخلية
+
+108
+00:08:23,560 --> 00:08:27,580
+بنلاقي انه بالفعل معطيانة شكل اللى هو ال awls eye
+
+109
+00:08:27,580 --> 00:08:31,720
+وهذا الانطباع حقيقة حتى لو ماكنتش الصورة موجودة
+
+110
+00:08:31,720 --> 00:08:35,080
+اللى هي الصورة الحقيقية هتاخدوا الانطباع مجرد
+
+111
+00:08:35,080 --> 00:08:39,060
+انكوا تشوفوا اللى هو صورة البوم اللى أعفن الاسمية
+
+112
+00:08:40,930 --> 00:08:46,030
+في حزمة اسمها تزناكسمير او تزناكسمير وهذا السمير
+
+113
+00:08:46,030 --> 00:08:50,250
+بياخدوه من المرضى اللى عندهم herpes labialis اللى
+
+114
+00:08:50,250 --> 00:08:53,810
+هو ال herpes اللى بصيب الشفاة لو أخدنا مسحها
+
+115
+00:08:53,810 --> 00:08:59,270
+وصبغناها على شريحة هنشوف فيها ال multi-nucleated
+
+116
+00:08:59,270 --> 00:09:03,370
+giant cell خلية عملاقة وهذه برضه دياجنوستيكا بناءت
+
+117
+00:09:03,370 --> 00:09:09,330
+لمين لل herpes simplex type 1 طيب
+
+118
+00:09:10,290 --> 00:09:13,590
+The clinical diagnosis of herpes skin infection
+
+119
+00:09:13,590 --> 00:09:20,590
+بمساعدة
+
+120
+00:09:20,590 --> 00:09:24,870
+وجود الـ multinucleated genes اللي احنا شفناها في
+
+121
+00:09:24,870 --> 00:09:28,890
+اللوحة السابقة With ezymophilic intracellular
+
+122
+00:09:28,890 --> 00:09:33,650
+internuclear inclusions الآن هذا بيرجعنا لل
+
+123
+00:09:33,650 --> 00:09:36,290
+concept الحقيقي اللي ذكرناها في السابقإن
+
+124
+00:09:36,290 --> 00:09:41,250
+الـCytopathic Effect أو الـCPE is an indication أو
+
+125
+00:09:41,250 --> 00:09:45,170
+is an aid in the diagnosis of viral infection لذلك
+
+126
+00:09:45,170 --> 00:09:50,050
+إذا أردتم أن تصبحوا جيدين في عملية ال diagnoses
+
+127
+00:09:50,050 --> 00:09:53,610
+للفيروس بيكونوا تعرفوا شغلتين أساسيات الشغل الأولى
+
+128
+00:09:53,610 --> 00:09:58,830
+what a normal cell culture looks like كيف تبدو
+
+129
+00:09:58,830 --> 00:10:05,010
+مزرعة خلايا عادية وكيف تبدولما يكون عليها
+
+130
+00:10:05,010 --> 00:10:07,170
+psychopathic effect، يعني الـ pathological changes
+
+131
+00:10:07,170 --> 00:10:11,790
+اللي بتحدث من تغيير إما lyses تحلل الخلايا أو إما
+
+132
+00:10:11,790 --> 00:10:16,250
+syncytia تتجمع الخلايا أو multinucleated أو كنا
+
+133
+00:10:16,250 --> 00:10:19,750
+فيها بيكون intra nuclear أو intra cytoplasmic
+
+134
+00:10:19,750 --> 00:10:20,510
+bodies
+
+135
+00:10:25,200 --> 00:10:28,300
+Infection with certain viruses causes malignant
+
+136
+00:10:28,300 --> 00:10:31,220
+transformation وهو الكلمة اللي اتفقناها هي
+
+137
+00:10:31,220 --> 00:10:38,940
+Hepatitis B, Hepatitis C, Papilloma Viruses تندرج
+
+138
+00:10:38,940 --> 00:10:42,740
+تحت إطار كبير اسمه Oncoviruses، these viruses may
+
+139
+00:10:42,740 --> 00:10:47,630
+transform a normal cell to a malignant cellWhat
+
+140
+00:10:47,630 --> 00:10:51,470
+distinguish a malignant cell from a normal cell؟
+
+141
+00:10:51,470 --> 00:10:56,510
+رقم واحد Unrestrained growth يعني قدرتها اللي لا
+
+142
+00:10:56,510 --> 00:11:01,890
+محدودة على النمو عمرها الطويليعني بيقولوا انه
+
+143
+00:11:01,890 --> 00:11:06,190
+virtually نظريا انه they can live forever اذا انت
+
+144
+00:11:06,190 --> 00:11:10,630
+اعطتهم الغذاء الملائم و ازالت منهم ال metabolite
+
+145
+00:11:10,630 --> 00:11:14,050
+السيئة تمام؟ فممكن ينمو لكن ال normal cells لها
+
+146
+00:11:14,050 --> 00:11:18,690
+normal life span لها عمر محدد مش زي ال malignant
+
+147
+00:11:18,690 --> 00:11:26,940
+cell الاحتمال الرابع اللي قلنا عنه هواحتمال وارد
+
+148
+00:11:26,940 --> 00:11:31,980
+في كثير من الفيروسات وخاصة تلك التي تمتلك envelope
+
+149
+00:11:31,980 --> 00:11:37,080
+وهي مغادرة بتاخد يزق من مين؟ من ال cell membrane
+
+150
+00:11:37,080 --> 00:11:41,640
+وبتطلع والخلية ولا يبدو عليها شيء لكن بدأ احكيلكم
+
+151
+00:11:41,640 --> 00:11:46,400
+عن نقطة مهمة في هذا الإطار كلكم فاكرين ان الفيروس
+
+152
+00:11:46,400 --> 00:11:50,000
+كان يطلع glycoproteins يشبكهم مع مين؟ مع ال cell
+
+153
+00:11:50,000 --> 00:11:53,480
+membrane تبقى الخلية المصابةهذه الـ Glycoprotein
+
+154
+00:11:53,480 --> 00:11:58,960
+هي مش our own it is a virus Glycoprotein ولهذه
+
+155
+00:11:58,960 --> 00:12:02,700
+المناعة تبعنا احنا بيبقى عامل زي شرطة المرور
+
+156
+00:12:02,700 --> 00:12:08,600
+بيمروا على الخلايا انت self self self self اه هذه
+
+157
+00:12:08,600 --> 00:12:14,360
+الخلية في عليها abnormal proteins
+
+158
+00:12:14,360 --> 00:12:20,990
+يبقى هذا مش self attack اهجمفاللي بدمر الخلايا تحت
+
+159
+00:12:20,990 --> 00:12:28,510
+الـ organ المصاب بفيروس لا يعطي اي morphologic ولا
+
+160
+00:12:28,510 --> 00:12:32,070
+functional changes اللي بدمرها غالبا من جهاز
+
+161
+00:12:32,070 --> 00:12:37,170
+المناع وهذا ما يحدث في التهاب الكبد الوبائي B وC
+
+162
+00:12:37,170 --> 00:12:41,070
+لأن الفيروس نفسه ما بيحدث اي change لكن اللي بيحدث
+
+163
+00:12:41,070 --> 00:12:46,580
+ال change هذا من جهاز المناعكل هذه الملاحظات
+
+164
+00:12:46,580 --> 00:12:53,700
+بتورينا إن الـ Viral Infection مش واحدة قد تؤدي
+
+165
+00:12:53,700 --> 00:12:57,380
+لموت، قد تؤدي إلى Fusion، قد تؤدي إلى
+
+166
+00:12:57,380 --> 00:13:00,800
+Transformation، قد لا تؤدي إلى أي Change أو
+
+167
+00:13:00,800 --> 00:13:03,800
+Pathological Change، هذا بيعطينا Wide Variation
+
+168
+00:13:03,800 --> 00:13:09,680
+للـ Effect تبع الفيروس خلصنا من الاحتمالات الأربعة
+
+169
+00:13:09,680 --> 00:13:14,380
+اللي الفيروس ممكن يعملها في مين؟في cell على مستوى
+
+170
+00:13:14,380 --> 00:13:17,620
+الخلوي أو على مستوى الخلية المصابة نتكلم الآن على
+
+171
+00:13:17,620 --> 00:13:22,080
+مستوى ال host اللي هو العائل بشكل كامل رقم واحد
+
+172
+00:13:22,080 --> 00:13:26,420
+بيتكلم عن ال transmission هل الفيروسات كلها بتنتقل
+
+173
+00:13:26,420 --> 00:13:29,200
+بنفس الطريقة ولا في فيروسات تنتقل عن طريق ال
+
+174
+00:13:29,200 --> 00:13:32,200
+respiratory tract في بينتقل عن طريق الجلد في
+
+175
+00:13:32,200 --> 00:13:35,440
+بينتقل عن طريق الفيكل oral لأ في طرق متنوعة
+
+176
+00:13:35,440 --> 00:13:37,900
+ومختلفة هنتعرف عليها ان شاء الله في ال
+
+177
+00:13:37,900 --> 00:13:44,870
+transmission ال replicationالفيروس بيدخل خلية عشان
+
+178
+00:13:44,870 --> 00:13:49,290
+يتكاثر فيها لازم يدخلها عشان يدخلها لازم يرتبط
+
+179
+00:13:49,290 --> 00:13:52,570
+فيها عشان يرتبط فيها لازم يكون له receptors ففي
+
+180
+00:13:52,570 --> 00:13:55,930
+نوع من ال specificity جونا في الارتباط لكن إذا دخل
+
+181
+00:13:55,930 --> 00:14:00,650
+خلية هيتكاثر في الغالب فيها و يخرج و يصيب خلايا
+
+182
+00:14:00,650 --> 00:14:05,050
+أخرى يعني ال damage بيصيرش منالفيروس اللي دخل أول
+
+183
+00:14:05,050 --> 00:14:08,770
+مرة خربله خلية و لا خليتين و لا عشر خلايا ال
+
+184
+00:14:08,770 --> 00:14:12,990
+damage بيحدث متى؟ لما هدول العشرة يتكاتروا و
+
+185
+00:14:12,990 --> 00:14:16,690
+يصيروا مئات أو آلاف و يغزوا خلايا فال damage بيكون
+
+186
+00:14:16,690 --> 00:14:19,970
+كبير فبتحدث اللي هو الأعراض اللي احنا بنعرفها
+
+187
+00:14:20,720 --> 00:14:25,180
+Spread of the virus to other cells and organs The
+
+188
+00:14:25,180 --> 00:14:28,900
+immune response الآن معظم ال viral infection
+
+189
+00:14:28,900 --> 00:14:33,280
+بتوقفها ال immune system بتعامل معاها بال cell
+
+190
+00:14:33,280 --> 00:14:37,220
+mediated immunity اللي هي humoral immunity وبيشفى
+
+191
+00:14:37,220 --> 00:14:44,620
+تلقائيا رقم أربعة هي اللي احنا بنشوفه باستمرار لكن
+
+192
+00:14:44,620 --> 00:14:48,740
+هناك استثناء دوما في رقم خمسةإن الجهاز المنع لم
+
+193
+00:14:48,740 --> 00:14:54,020
+يستطع أو إن الفيروس نفسه يمتلك صفات أهلته إنه
+
+194
+00:14:54,020 --> 00:14:57,760
+يتخطى جهاز المنع فقد تتحول إلى ما يسمى بال
+
+195
+00:14:57,760 --> 00:15:04,060
+persistence infection يعني عدوى مستقرة ثابتة في
+
+196
+00:15:04,060 --> 00:15:08,660
+هذا الإنسان فيه قلنا في مين في some cases مش في كل
+
+197
+00:15:08,660 --> 00:15:15,240
+الحلقة طيب ال stages تشبه إلى حد كبير لل stages
+
+198
+00:15:15,240 --> 00:15:19,810
+تبع ال bacterial infectionأول مرحلة اللي هي الـ
+
+199
+00:15:19,810 --> 00:15:23,170
+Incubation Period و الـ Incubation Period هي
+
+200
+00:15:23,170 --> 00:15:27,910
+الفترة من دخول الفيروس إلى ظهور الأعراض و هذه الـ
+
+201
+00:15:27,910 --> 00:15:31,670
+Incubation Period غالبا ما بيكون فيها أي أعراض و
+
+202
+00:15:31,670 --> 00:15:35,690
+ما بنعرف أصلا إن الشخص عنده Viral Infection أو لا
+
+203
+00:15:35,690 --> 00:15:40,990
+المرحلة اللي بعديها هي مرحلة تسبق دائما الـ Viral
+
+204
+00:15:40,990 --> 00:15:42,530
+Infection أو الـ Bacterial Infection اسمها الـ
+
+205
+00:15:42,530 --> 00:15:46,120
+Prodromal Periodو الـ Prodromal Period احنا
+
+206
+00:15:46,120 --> 00:15:50,700
+بنوصفها بالعمية، بنقول أنا حاسس حالي بدي أمرضطب
+
+207
+00:15:50,700 --> 00:15:54,900
+كيف حاسس أنك بتتمرض؟ لا يبدو عليك أي علامات مميزة
+
+208
+00:15:54,900 --> 00:15:59,700
+للمرض، أقولك أنا مثلا حاسس حالي مرهق، عنيا
+
+209
+00:15:59,700 --> 00:16:02,740
+دابلانين، حاسس حالي بدي أسخن، و هو مش سخن، لو جثنا
+
+210
+00:16:02,740 --> 00:16:06,540
+حرارة تبلاجيها سبعة و تلاتين، لكن هذه الأعراض اللي
+
+211
+00:16:06,540 --> 00:16:10,300
+non specific اللي بتعطي شعور بإنه بدي مرض نسميه
+
+212
+00:16:10,300 --> 00:16:14,500
+احنا prodromal period، يتبعها طبعا تاني يوم الصبح
+
+213
+00:16:14,500 --> 00:16:20,010
+بلاجة حاله، بعطس، بكح،رجليه بيجأو، حرارة مرتفعة
+
+214
+00:16:20,010 --> 00:16:24,090
+لجثنها لجنة 38، هذه اللي بيسميها specific illness
+
+215
+00:16:24,090 --> 00:16:28,090
+period، إذا incubation period، prodromal period،
+
+216
+00:16:28,090 --> 00:16:31,030
+specific illness period، تالت أربع أيام viral
+
+217
+00:16:31,030 --> 00:16:34,290
+infection على سبيل المثال، وبعدين يبدأ يتحسن، اللي
+
+218
+00:16:34,290 --> 00:16:39,740
+هي recovery periodبيرجع فيها تدرجيا إلى ال normal
+
+219
+00:16:39,740 --> 00:16:44,980
+health كمان مرة in some cases .. in some cases
+
+220
+00:16:44,980 --> 00:16:47,900
+مابصير الشفاء ولا كان .. ليش في ناس بتموت من ال
+
+221
+00:16:47,900 --> 00:16:53,100
+influenza لو صار شفاء؟يبقى in some cases بيصير فيه
+
+222
+00:16:53,100 --> 00:16:58,000
+انه اما ب resistance او بيصير انه chronic carrier
+
+223
+00:16:58,000 --> 00:17:01,940
+state او انه رقم اربعة مابتجومش بدورها كاملا
+
+224
+00:17:01,940 --> 00:17:05,520
+فبيفشل جهاز المناع في القضاء على الفيروس وقد يقتل
+
+225
+00:17:05,520 --> 00:17:08,910
+الفيروس اللي هو المريضزي ما قلتلكوا احنا في نسبة
+
+226
+00:17:08,910 --> 00:17:12,410
+خمسة بالمائة وفيات لمرض بسيط زي المرض من ال
+
+227
+00:17:12,410 --> 00:17:15,030
+influence فانتوا بالكوا لما اتكلم عن ابولا اللي
+
+228
+00:17:15,030 --> 00:17:18,590
+وصل تسعين بالمائة حالة وفيات عن influenza الطيور
+
+229
+00:17:18,590 --> 00:17:22,190
+حوالي تلات ستين بالمائة نسبة اللي هو الوفية
+
+230
+00:17:22,190 --> 00:17:25,990
+transmission
+
+231
+00:17:25,990 --> 00:17:30,590
+and portal of entry transmission and portal او
+
+232
+00:17:30,590 --> 00:17:35,250
+portals of entry person to person spread a car via
+
+233
+00:17:35,250 --> 00:17:38,510
+transfer of respiratory secretionطبعا ال
+
+234
+00:17:38,510 --> 00:17:41,470
+respiratory circulation اللي هي الإفرازات اللي
+
+235
+00:17:41,470 --> 00:17:44,490
+ناجي معانا الجهاز التنفسي اللي ناجي معانا العطس أو
+
+236
+00:17:44,490 --> 00:17:49,530
+الكلام أو الكحة كلها ممكن تنتقل في كمان شغل مهمة
+
+237
+00:17:49,530 --> 00:17:53,930
+saliva تمام اللي هو اللعاب تبع المريض المصاب ال
+
+238
+00:17:53,930 --> 00:17:57,750
+blood و ال blood ممكن يكون من طريقتين blood
+
+239
+00:17:57,750 --> 00:18:04,700
+transfusion انه احنا بتعرفواكثير من المرضى في قطاع
+
+240
+00:18:04,700 --> 00:18:08,460
+غزة نظرا لعدم توفر إمكانيات معينة بينتقلوا إلى دول
+
+241
+00:18:08,460 --> 00:18:14,380
+أخرىلإجراء عملية جراحية هذه العملية المفروض أنها
+
+242
+00:18:14,380 --> 00:18:18,120
+عملية بسيطة وممكن يعني بكل سهولة في الدولة الأخرى
+
+243
+00:18:18,120 --> 00:18:22,940
+تجرأ لولد الإمكانيات و تجرأ و تنجح العملية لكن
+
+244
+00:18:22,940 --> 00:18:27,200
+المرض يعود بـ Hepatitis C على سبيل المثال لا نريد
+
+245
+00:18:27,200 --> 00:18:32,200
+أن نذكر دول ولكن هذا شيء صار معروف لدينا في قطاع
+
+246
+00:18:32,200 --> 00:18:35,800
+غزة أن المرض اللي بيروح لدولة معينة برجع بنسبة
+
+247
+00:18:35,800 --> 00:18:38,850
+كبيرة بـ Hepatitis Cليش؟ لأنه في العمليات الجراحية
+
+248
+00:18:38,850 --> 00:18:43,350
+بيتطروا يعطوهم blood أو بيستخدموا أدوات غير معقمة
+
+249
+00:18:43,350 --> 00:18:48,050
+من مريض إلى مريض طريقة تانية للانتقال في ال blood
+
+250
+00:18:48,050 --> 00:18:51,110
+اللي هي طريقة اللي هو ال needle sharing اللي
+
+251
+00:18:51,110 --> 00:18:54,550
+حاكينا عنها اللي هو تبعون المخدرات semen طبعا
+
+252
+00:18:54,550 --> 00:18:56,930
+معاهمة في المفهوم أنه هذا من خلال اللي هو sexual
+
+253
+00:18:56,930 --> 00:19:02,070
+transmission فكأة ال contamination of water or
+
+254
+00:19:02,070 --> 00:19:05,910
+foodوأعتقد أن المحاضرة ماضي قضية نوع طويل في
+
+255
+00:19:05,910 --> 00:19:10,850
+الحديث عن أن أكبر ملوث لمياه الشرب والمياه
+
+256
+00:19:10,850 --> 00:19:16,150
+الاستجمام هي الـFecal Material أو الـ Sewage وعليه
+
+257
+00:19:16,150 --> 00:19:21,990
+فاحتمالية وخاصة في بلدان كما ذكرت كبلدان ننامية أن
+
+258
+00:19:21,990 --> 00:19:25,410
+الـSewage System مش كله Complete أو Closed System
+
+259
+00:19:25,410 --> 00:19:28,970
+فبالتالي إمكانية انتقال هذه الفيروسات بتكون عالية
+
+260
+00:19:28,970 --> 00:19:35,400
+جدالو روحنا على بلدان متطورة عندهم very perfect
+
+261
+00:19:35,400 --> 00:19:39,820
+discharge system و treatment system هلاجئ ان هذه
+
+262
+00:19:39,820 --> 00:19:46,340
+الأمراض لا تشكل ابقى على هذه البلدان هذا تشرح لل
+
+263
+00:19:46,340 --> 00:19:51,320
+blood اللي احنا حكيناه قبل قليلطيب Transmission من
+
+264
+00:19:51,320 --> 00:19:59,240
+الأم إلى المولود كيف تتم؟ هناك ثلاث مراحل يمكن من
+
+265
+00:19:59,240 --> 00:20:05,640
+خلالها انتقال الفيروس من الأم إلى الطفل في المرحلة
+
+266
+00:20:05,640 --> 00:20:08,860
+الجنانية وبنسميها in neutral في الرحم يعني تمام؟
+
+267
+00:20:08,860 --> 00:20:12,240
+والمرحلة التانية اللي هي at the time of delivery
+
+268
+00:20:12,240 --> 00:20:18,160
+وقت الولادة وقت الولادةوده هنبّه بس لنقطة الولادة،
+
+269
+00:20:18,160 --> 00:20:24,580
+الولادة عملية صحيح طبيعية، لكن عملية عنيفة وصعبة،
+
+270
+00:20:24,580 --> 00:20:31,410
+بيتم فيها تهتك كبير لأنسجةوتهتك ليه؟ ودماء، دماء
+
+271
+00:20:31,410 --> 00:20:35,150
+كثيرة وكلمة دماء يعني أي مايكروب كان مولود في دماء
+
+272
+00:20:35,150 --> 00:20:40,930
+الام تمام ممكن يلامس من الآن الطفل وأيضا عند خروج
+
+273
+00:20:40,930 --> 00:20:43,110
+الطفل من قناة الولادة كما اتعلمتهم في ال
+
+274
+00:20:43,110 --> 00:20:46,530
+diagnostic microbiology هناك بعض الأمراض انتقلت من
+
+275
+00:20:46,530 --> 00:20:51,490
+الأم إلى من؟ إلى الطفل زي الـGonorrhea زي
+
+276
+00:20:51,490 --> 00:20:54,790
+الـGonorrhea مشهورة كتير في موضوع الـOphthalmia
+
+277
+00:20:54,790 --> 00:20:59,060
+Neonatrum اللي بتصيب العينإذن in-neutral at the
+
+278
+00:20:59,060 --> 00:21:03,260
+time of delivery وفي مرحلة تالتة الإم مصرة إنها
+
+279
+00:21:03,260 --> 00:21:06,940
+تعطي الفيروس لأبنها من خلال مين؟ ال breast feeding
+
+280
+00:21:06,940 --> 00:21:12,320
+طبعا احنا هذه بس ممزحة يبقى في تلت مراحل ممكن
+
+281
+00:21:12,320 --> 00:21:16,940
+انتقل فيها الفيروس in-neutral at the time of
+
+282
+00:21:16,940 --> 00:21:21,650
+delivery during breast feedingالانتقال من الأم إلى
+
+283
+00:21:21,650 --> 00:21:26,550
+الطفل بنسميها .. للمولود يعني بنسميها vertical
+
+284
+00:21:26,550 --> 00:21:31,170
+transmission انتقال عمودي بينما لو بنتقل الفيروس
+
+285
+00:21:31,170 --> 00:21:35,870
+من شخص إلى شخص بنسميها horizontal طبعا ال M لل
+
+286
+00:21:35,870 --> 00:21:38,890
+offspring تمام؟ بس من .. من .. من شخص إلى شخص
+
+287
+00:21:38,890 --> 00:21:44,930
+بنسميها horizontal transfer في كمان جانب احنا ما
+
+288
+00:21:44,930 --> 00:21:47,030
+.. ما طرقناله في ال transmission اللي هو ال animal
+
+289
+00:21:47,030 --> 00:21:55,390
+to humanبتسمعوا انه 60% من الأمراض المعضية هي
+
+290
+00:21:55,390 --> 00:22:00,970
+أمراض مشتركة بين الحيوان و الإنسان قد ينقل الحيوان
+
+291
+00:22:00,970 --> 00:22:04,370
+إلى الإنسان و قد ينقل الإنسان أيضا لمن؟ للحيوان
+
+292
+00:22:04,370 --> 00:22:09,290
+يعني مثلا تكسب
+
+293
+00:22:09,290 --> 00:22:12,550
+لازموسز المشهورة تبعة القطط اللي موجودة هذه
+
+294
+00:22:12,550 --> 00:22:17,360
+برازايت تمام؟في عندنا الـ Pasturella اللى تنتقل عن
+
+295
+00:22:17,360 --> 00:22:22,520
+طريق برضه القطط بكتيريا عن طريق القطط للإنسان بعض
+
+296
+00:22:22,520 --> 00:22:27,600
+أنواع من الفطريات تنتقل من القطط أيضا للإنسان أنا
+
+297
+00:22:27,600 --> 00:22:32,300
+ركزت على حيوان واحة تمام؟ عشان في بعض الناس ابتسمت
+
+298
+00:22:32,300 --> 00:22:36,200
+لإنهم معرفين حالهم إنهم هم صاروا عرضة لهذه الأمراض
+
+299
+00:22:37,810 --> 00:22:41,810
+لكن بشكل عام الانتقال من الحيوان إلى الإنسان بتم
+
+300
+00:22:41,810 --> 00:22:46,850
+بطريقتين إما مباشرة و مثلا أنا أخدت مثال هنا فيروس
+
+301
+00:22:46,850 --> 00:22:50,490
+ال rabies اللي هو ده الكلب ممكن عن طريق عضة
+
+302
+00:22:50,490 --> 00:22:55,010
+الحيوان مباشرة للإنسان سواء كان خفاش أو قنة اللي
+
+303
+00:22:55,010 --> 00:23:01,200
+هو ال .. ال .. ال ..الكلب المصاب أو indirectly عبر
+
+304
+00:23:01,200 --> 00:23:06,200
+البعوض الحشرات الناقلة ال yellow fever ال dingy
+
+305
+00:23:06,200 --> 00:23:11,860
+fever تمام ال West Nile virus كلها أمراض تنتقل من
+
+306
+00:23:11,860 --> 00:23:15,920
+الحيوان إلى الإنسان لكن من خلال إيه؟ من خلال
+
+307
+00:23:15,920 --> 00:23:20,400
+viruses من خلال أفر من خلال vector اللي هو ال
+
+308
+00:23:20,400 --> 00:23:23,900
+mosquitoes إذا إما directly أو indirectly
+
+309
+00:23:26,390 --> 00:23:32,270
+في مصدر للعدوى مارضو ما بنكرره كتير احنا بس هو اول
+
+310
+00:23:32,270 --> 00:23:36,470
+مرة بيكون من external source، من مصدر خارجي، لكن
+
+311
+00:23:36,470 --> 00:23:42,560
+تخيلوا شخص عنده herpes simplexوشو فيها منه؟ أصيب
+
+312
+00:23:42,560 --> 00:23:47,200
+فيه أول مرة انتقل من أمه له للطفل أو من أبوه للطفل
+
+313
+00:23:47,200 --> 00:23:50,960
+أثناء التقبيل هو صغير واحد من الولدين كان مصاب
+
+314
+00:23:50,960 --> 00:23:55,040
+وقبل الطفل فنقله مين؟ اللي هو ال herpes simplex
+
+315
+00:23:55,040 --> 00:23:58,720
+هذا الطفل أخده مرة واحدة من direct contact من جلد
+
+316
+00:23:58,720 --> 00:24:03,960
+لجلد تمام؟ لكن بعد أربع سنين أو خمس سنين طلع للطفل
+
+317
+00:24:03,960 --> 00:24:10,660
+حم في منطقة الفمهذا ليس فيروس جايبه من برا، هو كان
+
+318
+00:24:10,660 --> 00:24:15,200
+مختبئ عنده اللي هو latent infection الصفة اللي
+
+319
+00:24:15,200 --> 00:24:18,740
+ربطناها بال herpes viruses فاكرينها؟ قلنا لكوا ان
+
+320
+00:24:18,740 --> 00:24:21,720
+ال herpes viruses عندها قدرة على الكمون أو ال
+
+321
+00:24:21,720 --> 00:24:26,060
+latency اللي هي مثال عليها، فهو أول مرة external،
+
+322
+00:24:26,060 --> 00:24:29,640
+لكن في هذه الحالة لم يكن external، هو مصدر
+
+323
+00:24:29,640 --> 00:24:35,180
+internal ناخده الطفل من عندههذه الجدولة كتير حلوة
+
+324
+00:24:35,180 --> 00:24:39,760
+ومهمة ورايعة جدا انها بتلخصلي ال portal of entry
+
+325
+00:24:39,760 --> 00:24:42,900
+طبعا الان كل الأسماء اللي موجودة هذه أصبحت
+
+326
+00:24:42,900 --> 00:24:47,160
+familiar لديكمدكرناها مرارا و تكرارا و أصبحت
+
+327
+00:24:47,160 --> 00:24:51,420
+بالفعل سهل أنه نتكلم فيها بدون ما نقول إيش هي هذه
+
+328
+00:24:51,420 --> 00:24:54,920
+الفيروسات طلعولي مجموعة ال respiratory viruses
+
+329
+00:24:54,920 --> 00:24:58,960
+عندي influenza virus بسبب ال influenza ال
+
+330
+00:24:58,960 --> 00:25:01,400
+rhinovirus بسبب ال common cold ال respiratory
+
+331
+00:25:01,400 --> 00:25:05,560
+syncytial virus بسبب ال broncolitis Epstein أو
+
+332
+00:25:05,560 --> 00:25:08,380
+بشتاعين بعرف فيروس infectious mononucleosis
+
+333
+00:25:08,380 --> 00:25:12,730
+Varicella zoster chickenpoxHerpes Simplex Type I
+
+334
+00:25:12,730 --> 00:25:16,470
+Herpes Labialis Labialis يعني الشفاءالـ
+
+335
+00:25:16,470 --> 00:25:20,210
+Respiratory Tract ما زلنا فيها Cytomegalovirus،
+
+336
+00:25:20,210 --> 00:25:23,750
+Micelles Virus، Mumps Virus، Rubella Virus، كل ما
+
+337
+00:25:23,750 --> 00:25:25,570
+دول اللي رسمناهم من المحاضرة السابقة لما تكلمنا عن
+
+338
+00:25:25,570 --> 00:25:31,790
+تصنيف اللي هو الـ RNA Viruses وقولنا MMR اللي هو
+
+339
+00:25:31,790 --> 00:25:36,030
+ال vaccine، Micelles, Mumps and Rubella طبعا الـ
+
+340
+00:25:36,030 --> 00:25:40,030
+Hantavirus بسبب نيمونيا والأدينوفيروس أيضا بسبب
+
+341
+00:25:40,030 --> 00:25:45,000
+النيمونيا، هذا لا يعنيإن الأمراض اللي موجودة في
+
+342
+00:25:45,000 --> 00:25:48,990
+العمود الأخرهي فقط تلك اللتي تسبب هذه الفيروسات
+
+343
+00:25:48,990 --> 00:25:53,130
+يعني مثلا هندفن مثال على one disease caused by a
+
+344
+00:25:53,130 --> 00:25:57,230
+adenovirus اسمه الـ pneumonia لكن مر معانا في
+
+345
+00:25:57,230 --> 00:26:00,810
+المحاضرة السابقة انها بتعمل pharyngitis لما
+
+346
+00:26:00,810 --> 00:26:04,990
+قولنالكوا انه هي من أشهر مسببات التنسولايتس لدى
+
+347
+00:26:04,990 --> 00:26:11,170
+الأطفال من النوع الفيروسي طبعا قد تقابل في النسبة
+
+348
+00:26:11,170 --> 00:26:15,070
+تلك اللتي تسببها البكتيرا ليس مسترد كوكاس بيو جينز
+
+349
+00:26:15,070 --> 00:26:19,540
+إذا ال respiratory tractمصدر مهم جدا جدا للعدوى
+
+350
+00:26:19,540 --> 00:26:25,260
+لمجموعة كبيرة من ال pathogens بدي اجابة انتقل
+
+351
+00:26:25,260 --> 00:26:30,520
+للوحة التانية تنتبهوا لشغل كمان انه قد نجد بعض ..
+
+352
+00:26:30,520 --> 00:26:37,520
+قد نجد بعض الفيروسات تنتقل باكثر من وسيلة واذكرولي
+
+353
+00:26:37,520 --> 00:26:41,240
+الربلا وبيع السياسة بالمثال من هذه المجموعة
+
+354
+00:26:41,240 --> 00:26:44,400
+gastrointestinal
+
+355
+00:26:44,400 --> 00:26:49,100
+tract infectionطبعا احنا المحاضرة السابقة ايضا
+
+356
+00:26:49,100 --> 00:26:53,240
+تحدثنا في معرض حديثنا عن ال classification ل ال ..
+
+357
+00:26:53,240 --> 00:26:56,960
+ال medically important viruses انه البعض كيف ينتقل
+
+358
+00:26:56,960 --> 00:27:01,220
+و ذكرنا انه فيك ال oral مجموعة كبيرة مش صغيرة و
+
+359
+00:27:01,220 --> 00:27:04,980
+هذه أمثلة عليها hepatitis A virus اللي بسبب
+
+360
+00:27:04,980 --> 00:27:07,820
+hepatitis A طبعا ال poliovirus اللي بسبب شر
+
+361
+00:27:07,820 --> 00:27:11,760
+الأطفال او ال poliomyelitis و ال rotavirus الشهير
+
+362
+00:27:11,760 --> 00:27:14,460
+اللي بيعمل دياريات انا بعتقد ان هو كلمة واحدة
+
+363
+00:27:14,460 --> 00:27:19,510
+rotavirus مش مفصلين عن بعض rotavirusSkin عن طريق
+
+364
+00:27:19,510 --> 00:27:24,710
+الجلب ريبز فيروس وكتير سيدنا حاكين عنه Yellow
+
+365
+00:27:24,710 --> 00:27:29,470
+fever virus, dingy virus, human papilloma virus
+
+366
+00:27:29,470 --> 00:27:35,630
+افضل مثال على ان في فيروس واحد اكتر من طريقة هيوم
+
+367
+00:27:35,630 --> 00:27:38,730
+ورا بعضالـ Human Papilloma Virus كان ويما انتقل عن
+
+368
+00:27:38,730 --> 00:27:42,670
+طريق الـ Skin، والآن بنتقل أيضا كمعالمين الـ
+
+369
+00:27:42,670 --> 00:27:46,110
+Genital tract.بنفهم كمان شغل، انه زي البكتيريا ما
+
+370
+00:27:46,110 --> 00:27:51,410
+هي سلالات، strains، كمان ال viruses، strains،
+
+371
+00:27:51,410 --> 00:27:55,370
+بمعنى انه الـ Sterology دي باعها مختلف من واحد
+
+372
+00:27:55,370 --> 00:28:00,550
+لواحد، وبالتالي قد نرى ارتباط وثيق بين Serotypes
+
+373
+00:28:00,550 --> 00:28:05,460
+ومرض معين.مش كل الـ Serotypes بما يكون هذا المرض
+
+374
+00:28:05,460 --> 00:28:08,560
+فعلى سبيل المثال اللي بينتقلوا عن طريق الجلد ال
+
+375
+00:28:08,560 --> 00:28:13,360
+tract اللي هو مرقام محددة و غالبا بيأدوا إلى أورام
+
+376
+00:28:13,360 --> 00:28:17,760
+سرطانية لكن اللي بينتقلوا عن طريق الجلد مابيأدوش
+
+377
+00:28:17,760 --> 00:28:22,440
+إلى أورام مثلاسرطاني إذا اللي بدي أقوله أنا أن ال
+
+378
+00:28:22,440 --> 00:28:26,320
+virus قد ينتقل بأكتر من وسيلة و أنا قلتلكوا أربطوا
+
+379
+00:28:26,320 --> 00:28:29,460
+في الأذهان اللي هو ال virus روبيلا ال virus هنشوفه
+
+380
+00:28:29,460 --> 00:28:33,440
+كمان شوية وهي لجينا هنا ال human ببقى بل هو virus
+
+381
+00:28:33,440 --> 00:28:37,460
+و ال human ببقى بل هو virus و hepatitis B لجيناها
+
+382
+00:28:37,460 --> 00:28:41,360
+في ال genital tract و هنلاجيها كمان شوية في ال
+
+383
+00:28:41,360 --> 00:28:44,670
+blood في اللوحة اللي وراها على طولالـ blood وين
+
+384
+00:28:44,670 --> 00:28:48,090
+اللي جينا بيه؟ حياتها، شايفينها؟ يبقى انتقلت بالـ
+
+385
+00:28:48,090 --> 00:28:52,150
+genital tract وانتقلت عن طريق اللي هو ال blood
+
+386
+00:28:52,150 --> 00:28:59,740
+transfusion، بينما الـ hepatitis Cماولدنهاش في
+
+387
+00:28:59,740 --> 00:29:02,720
+مين؟ في الـgenital، لكنها فقط مين؟ في الـblood.
+
+388
+00:29:03,000 --> 00:29:06,260
+Hepatitis D، وأعتقد أن دي هو أشهرهم بالنسبة لكم،
+
+389
+00:29:06,260 --> 00:29:09,400
+كونه هو الـdefective virus، الـhuman T cell
+
+390
+00:29:09,400 --> 00:29:13,220
+lymphotropic virus بتابع لنا لوكيميا، والـhuman
+
+391
+00:29:13,220 --> 00:29:17,160
+immunodeficiency virus، اللي هو مسئول عن إحداث مرض
+
+392
+00:29:17,160 --> 00:29:18,120
+الـAIDS.
+
+393
+00:29:20,620 --> 00:29:23,420
+الـtransplacental، اللي هو عبر الـplacenta خلال
+
+394
+00:29:23,420 --> 00:29:27,980
+عملية الولادة،انديسايتوميجالو فيروس لحظة كمان مرة
+
+395
+00:29:27,980 --> 00:29:31,900
+blood و Trans placental و الربلة اللى قولنا لكوا
+
+396
+00:29:31,900 --> 00:29:35,260
+احملوها من ال respiratory tract حين حملناها ايضا
+
+397
+00:29:35,260 --> 00:29:42,340
+مرة تانية وان في Trans placental Trans mission طيب
+
+398
+00:29:42,340 --> 00:29:47,580
+اللى احنا قولنا انه مجموعة الأمراض الفيروسية اللى
+
+399
+00:29:47,580 --> 00:29:54,270
+تنتقل من الأم إلىالمولود أو الجنين تمام مهمة
+
+400
+00:29:54,270 --> 00:29:56,890
+بالنسبة أن الصحية ومجموعة مش .. مش صغيرة لذلك
+
+401
+00:29:56,890 --> 00:30:01,170
+خصصنا لهم برضه لوحة viruses that commonly cause
+
+402
+00:30:01,170 --> 00:30:05,170
+perinatal infection ال .. ال .. ال perinatal بتلخص
+
+403
+00:30:05,170 --> 00:30:08,790
+بإنه في عندي حمل و في عندي ولادة و في عندي breast
+
+404
+00:30:08,790 --> 00:30:12,790
+feeding تلت .. تلت مواضع مهمين جدا في عملية
+
+405
+00:30:12,790 --> 00:30:17,770
+الولادة بشكل عام الحمل و الولادة نفسها و الرضاعة
+
+406
+00:30:19,410 --> 00:30:22,090
+الفيروس الأوامر مثلًا على الـ Transplant اللي
+
+407
+00:30:22,090 --> 00:30:26,750
+جوناه Cytomegalovirus البرفوفيروس، فاكرينه؟ ال
+
+408
+00:30:26,750 --> 00:30:30,110
+B19، إيش بقى بقى ال B19؟ هذا Slab Chick Syndrome
+
+409
+00:30:30,110 --> 00:30:33,450
+اللي هو جونا الخد المصفوع اللي بيكون لونه أحمر
+
+410
+00:30:34,580 --> 00:30:39,280
+الروبيلا فيروس ال جرم المسل هو كمان مرة بأكدلكوا
+
+411
+00:30:39,280 --> 00:30:43,740
+على انه الروبيلا اعطيتهم الفاكسين من أجل هذه
+
+412
+00:30:43,740 --> 00:30:48,380
+اللحظة حتى نمنع انتقال الفيروس إذا كانت الأم أصيبت
+
+413
+00:30:48,380 --> 00:30:52,160
+فترة الحمل حتى لا ينتقل هذا الفيروس إلى الجنين
+
+414
+00:30:52,160 --> 00:30:57,020
+ويحدث هذا الدرع ال time of birth hepatitis B و
+
+415
+00:30:57,020 --> 00:31:01,660
+hepatitis C فيروسHerpes simplex virus type 2 وهذا
+
+416
+00:31:01,660 --> 00:31:05,720
+sexually transmitted وبالتالي بيكون مولود في الأم
+
+417
+00:31:05,720 --> 00:31:10,220
+في ال vagina وبالتالي عبر الولادة الطبيعية هياخد
+
+418
+00:31:10,220 --> 00:31:16,220
+ال virus ال human immunodeficiency virusأمهات
+
+419
+00:31:16,220 --> 00:31:20,800
+مصابات نفس الجثة أطفالهم خلال عملية الولادة
+
+420
+00:31:20,800 --> 00:31:24,680
+بياخدوا ال virus طبعا ال human papillomavirus و ال
+
+421
+00:31:24,680 --> 00:31:28,760
+human papillomavirus لو كونه مرض كنا بينتقل عن
+
+422
+00:31:28,760 --> 00:31:34,740
+طريق الجنس العلماء و بسبب سرطان العلماء بيفتخروا
+
+423
+00:31:34,740 --> 00:31:40,530
+الآن بإن واحنا أنتجنا أول vaccine مضاد للسرطانليش
+
+424
+00:31:40,530 --> 00:31:43,970
+هم هم؟ مش لكل السرطان لكن لمن؟ للسرطان الناجر عن
+
+425
+00:31:43,970 --> 00:31:48,550
+من؟ عن ال papilloma virus فكل الفتيات اللي في سن
+
+426
+00:31:48,550 --> 00:31:53,990
+تسمح لهنا بالممارسة الجنسية في أمريكا وأوروبا
+
+427
+00:31:53,990 --> 00:31:57,150
+بياخدوا ال vaccine اللي اسمه human papilloma
+
+428
+00:31:57,150 --> 00:32:01,170
+vaccine HPV vaccine تمام؟ زي ما احنا بناخد اللي هو
+
+429
+00:32:01,170 --> 00:32:06,110
+الربلة vaccine وهذا يقطع فقط للإناث لأنه بيسبب
+
+430
+00:32:06,110 --> 00:32:12,770
+سرطان للإناث فقطbreast feeding, cytomegalovirus و
+
+431
+00:32:12,770 --> 00:32:16,270
+الـ human T cell lymphotropic virus طبعا هذا بيعمل
+
+432
+00:32:16,270 --> 00:32:23,390
+لوكيميا للأطفال طيب
+
+433
+00:32:23,390 --> 00:32:26,350
+medically important viruses that have an animal
+
+434
+00:32:26,350 --> 00:32:29,950
+reservoir animal reservoir يعني إلها مخزن من
+
+435
+00:32:29,950 --> 00:32:34,690
+الحيوانات بمعنى أخر حيوانات تصاب بهذا الفيروس قد
+
+436
+00:32:34,690 --> 00:32:36,110
+تمرض أو لا تمرض
+
+437
+00:32:40,520 --> 00:32:46,660
+مخازن للفيروسات Reservoirs تمام بتمر بمرحلة المرض
+
+438
+00:32:46,660 --> 00:32:49,900
+زي الإنسان مابمر مرحلة المرض وفي منها لا يمرض من
+
+439
+00:32:49,900 --> 00:32:53,600
+هذا الفيروس يعني أنواعها لا تمرض فكلمة reservoir
+
+440
+00:32:53,600 --> 00:32:59,300
+يعني حيوان قد ينقل إلينا هذا ال virus ال rabies
+
+441
+00:32:59,300 --> 00:33:03,320
+virus in the united states في الولايات المتحدة
+
+442
+00:33:03,320 --> 00:33:07,260
+skunks ماعرفش تعرفه ال skunk و لا تعرفهوش يسموه
+
+443
+00:33:07,260 --> 00:33:14,220
+ضرباناللي بيشبه سنجاب و داله طويل مخطط و رائحته
+
+444
+00:33:14,220 --> 00:33:19,380
+كريهة .. رائحته كريهة اسمه skunk راكونز ..
+
+445
+00:33:19,380 --> 00:33:22,180
+الراكونز برضه من الحيوانات اللي لها دال مخطط و
+
+446
+00:33:22,180 --> 00:33:27,670
+حلوة و جميلةBats ليها الخفافيش لكن in developing
+
+447
+00:33:27,670 --> 00:33:31,810
+countries معزلة الكلاب هي المسئولة أو الرزروار
+
+448
+00:33:31,810 --> 00:33:35,810
+الرئيسي لل rabies virus ال mood of the
+
+449
+00:33:35,810 --> 00:33:41,450
+transmission غالبا ال bite of infectedانمال او ال
+
+450
+00:33:41,450 --> 00:33:48,670
+aerosols of bat saliva يعني لست بحاجة ان ال bat
+
+451
+00:33:48,670 --> 00:33:53,850
+اصلا ييجي يعضك ممكن لو هو طاير و نزل منه saliva
+
+452
+00:33:53,850 --> 00:33:59,890
+على جروح انسان تمام او صار direct contact بين
+
+453
+00:33:59,890 --> 00:34:03,550
+انسان و بين خفاش دون ما يكون في حالة عض ممكن ينقل
+
+454
+00:34:03,550 --> 00:34:09,320
+له هذا المعلقالدزيز طبعا rabies صرت خبراء الان في
+
+455
+00:34:09,320 --> 00:34:12,500
+الفيروسات الان كل الفيروسات اتكررت معنا اكتر من
+
+456
+00:34:12,500 --> 00:34:16,500
+عشرين او تلاتين مرة اسمها الهنتا فيروس انواع من
+
+457
+00:34:16,500 --> 00:34:19,660
+الفرن سموها deer mice وسموها deer mice لإن
+
+458
+00:34:19,660 --> 00:34:23,520
+الرجليها رفاع وطوال زي الغزلان فسموها deer mice
+
+459
+00:34:23,520 --> 00:34:27,920
+aerosols of dried excreta ال aerosols اللي ورا
+
+460
+00:34:27,920 --> 00:34:33,520
+ذاذب الناجم عن المخلفات تبعت هذه الفرن الجافة
+
+461
+00:34:33,520 --> 00:34:38,780
+بودرة تبعتهابرضه هانتا فيروس Palmonary Syndrome هو
+
+462
+00:34:38,780 --> 00:34:42,300
+عبارة عن pneumonia ال yellow fever virus اللي هم
+
+463
+00:34:42,300 --> 00:34:46,040
+الحمّة الصفراء بتنتقل عن طريق ال .. ال .. أو ال
+
+464
+00:34:46,040 --> 00:34:50,590
+reservoir تبعها اللي هو القرودبيت اف ايدس موسكيتو
+
+465
+00:34:50,590 --> 00:34:55,450
+تبتعرف ان البعوض انواع واسماء عديدة من ضمن الاسماء
+
+466
+00:34:55,450 --> 00:34:59,010
+المشهورة في عالم البعوض اللي هو الادس مثلا
+
+467
+00:34:59,010 --> 00:35:02,730
+ايجيبتاي اللي هي الزعجة ايدس معناها الزعجة
+
+468
+00:35:02,730 --> 00:35:07,230
+ايجيبتاي هي الزعجة المصرية ويلها دور في نقل كثير
+
+469
+00:35:07,230 --> 00:35:12,720
+من الأمراضyellow fever، dingy fever، monkeys bite
+
+470
+00:35:12,720 --> 00:35:16,120
+of aedes mosquitoes برضه بسبب ال dingy، ال
+
+471
+00:35:16,120 --> 00:35:18,900
+encephalitis viruses و كلمة encephalitis شرحناها
+
+472
+00:35:18,900 --> 00:35:23,140
+المرة الماضية من التهاب الدماغ، ممكن wild birds زي
+
+473
+00:35:23,140 --> 00:35:26,360
+ال sparrows، بتعرفوا ال sparrow؟ أشهر عصفور عندنا
+
+474
+00:35:26,360 --> 00:35:30,000
+في غزة شوة اللي بتلاقوه دايما في الشوارع و على
+
+475
+00:35:30,000 --> 00:35:35,240
+السطوح و بعشعش في أي مكان في الدوارياسمه ..
+
+476
+00:35:35,240 --> 00:35:38,000
+العصفور الصغير هذا ال common هذا اسمه Sparrow مش
+
+477
+00:35:38,000 --> 00:35:40,880
+Jack Sparrow تعرفوا Jack Sparrow؟ وين Jack Sparrow
+
+478
+00:35:40,880 --> 00:35:46,920
+شفتوا هذا؟ وين شفتوا Jack Sparrow؟ في ال .. ال
+
+479
+00:35:46,920 --> 00:35:50,040
+pirates of the Caribbean مظبوط و على فكرة هذه
+
+480
+00:35:50,040 --> 00:35:54,900
+الشخصية Jack .. Jack Sparrow هذه شخصية مسلمة و
+
+481
+00:35:54,900 --> 00:35:58,160
+برابوسة اللي .. اللي .. اللي بيجيبوه في الفيلم على
+
+482
+00:35:58,160 --> 00:36:02,440
+أنه وحش و كده و برضه شخصية تركية كان سيد بحار
+
+483
+00:36:02,440 --> 00:36:10,090
+العالم يعني كان هوأكبر يعني قبطان كلمة يسمع اسمه
+
+484
+00:36:10,090 --> 00:36:13,710
+في منطقة يدب الرعو في تلك المنطقة من كتر مكان شهير
+
+485
+00:36:13,710 --> 00:36:18,410
+في انتصاراته البحرية، لكن التاريخ بيحاولوا يشوهوه
+
+486
+00:36:18,410 --> 00:36:22,410
+إلينا ويرجعونيها بصريقة عجيبة، المهم Sparrow هالة
+
+487
+00:36:22,410 --> 00:36:26,960
+اللي قدامنا هو إيه؟ الدوار اللي أنت بتعرفهbites of
+
+488
+00:36:26,960 --> 00:36:29,860
+various mosquitoes encephalitis فيه SARS
+
+489
+00:36:29,860 --> 00:36:33,080
+coronavirus نوع من ال cats قلنا لكوا اسمها civet
+
+490
+00:36:33,080 --> 00:36:37,960
+cats بتنقله برضه aerosols aerosols droplets و
+
+491
+00:36:37,960 --> 00:36:42,160
+بيسببنا ال SARS ال avian influenza و ال avian
+
+492
+00:36:42,160 --> 00:36:46,280
+influenza قلنا هي انفلونزا الطيور chicken and
+
+493
+00:36:46,280 --> 00:36:50,480
+other fowls اللي هو الدجاج و الطيور الأخرى
+
+494
+00:36:50,480 --> 00:36:56,550
+aerosols droplets guano فاكرين ال guanoالمخلفات
+
+495
+00:36:56,550 --> 00:37:00,610
+اللي بتنتج من الخفافيش تمام؟ بتنتج من الخفافيش
+
+496
+00:37:00,610 --> 00:37:07,390
+ممكن نقلنا influence طيب localized or disseminated
+
+497
+00:37:07,390 --> 00:37:11,990
+infection ما الذي نقصده في localized infection
+
+498
+00:37:11,990 --> 00:37:16,330
+localized يعني متموضعة يعني في مكان واحد بينما
+
+499
+00:37:16,330 --> 00:37:20,910
+disseminated يعني منتشرة في جسم الإنسان viral
+
+500
+00:37:20,910 --> 00:37:24,500
+infections are either localizedto the portal of
+
+501
+00:37:24,500 --> 00:37:27,360
+entry or spread systematically through the body
+
+502
+00:37:27,360 --> 00:37:32,360
+يعني واحد أخد فيروس رشح فيروس الرشح بيضله في منطقة
+
+503
+00:37:32,360 --> 00:37:35,100
+ال upper respiratory tract localized في تلك
+
+504
+00:37:35,100 --> 00:37:42,140
+المنطقة لكن لو أخد poly virus أخده عبر مين؟ عبر
+
+505
+00:37:42,140 --> 00:37:45,440
+الفكال oral ووصل ال intestine تكاثر في ال
+
+506
+00:37:45,440 --> 00:37:48,720
+intestine عمل invasion وروح على ال nerve cell ووصل
+
+507
+00:37:48,720 --> 00:37:51,960
+لل central nervous system هذا ايش بنسميه الآن؟
+
+508
+00:37:52,610 --> 00:37:55,750
+Spread Disseminated Infection الأولاني كان
+
+509
+00:37:55,750 --> 00:37:59,290
+Localized والتاني كان Disseminated Infection The
+
+510
+00:37:59,290 --> 00:38:01,650
+best example of the localized infection is the
+
+511
+00:38:01,650 --> 00:38:04,050
+common cold اللي حكيناه أنه فيروس رشح which
+
+512
+00:38:04,050 --> 00:38:08,930
+involves only the upper respiratory tract انفلونزا
+
+513
+00:38:08,930 --> 00:38:15,090
+غير الانفلونزا بتعمل upper وبعدين بتنزل على ال
+
+514
+00:38:15,090 --> 00:38:20,130
+lower respiratory tract وإذا فاكرين الفاكسيناللي
+
+515
+00:38:20,130 --> 00:38:24,730
+قلنا عنه استخدم ال conditional lethal mutation
+
+516
+00:38:24,730 --> 00:38:28,750
+اللي هي الطفرة المتعلقة بالحرارة بتكاثر في الأنف
+
+517
+00:38:28,750 --> 00:38:32,510
+لكن لو نزل إلى ال lungs بيبطل يتكاثر
+
+518
+00:38:37,640 --> 00:38:41,780
+الـ common cold localized بينما ال influenza
+
+519
+00:38:41,780 --> 00:38:45,200
+localized primarily في القبر لكن ممكن تنزل لمين؟
+
+520
+00:38:45,200 --> 00:38:46,960
+للهو ال respiratory لكن لما نقول عن الـ
+
+521
+00:38:46,960 --> 00:38:50,200
+disseminated اعتقد ان المثال اللي ذكرته مثال جيد
+
+522
+00:38:50,200 --> 00:38:55,250
+اللي هو مثال ال polio virusOne of the best
+
+523
+00:38:55,250 --> 00:38:58,230
+understood systemic viral infection is اللي هو ال
+
+524
+00:38:58,230 --> 00:39:01,890
+Paralytic Poliomyelitis، after poliovirus is
+
+525
+00:39:01,890 --> 00:39:04,510
+ingested، يعني تم تناوله عبر الماء الملوث أو
+
+526
+00:39:04,510 --> 00:39:07,870
+الطعام الملوث، it infects and multiply within the
+
+527
+00:39:07,870 --> 00:39:10,970
+cells of the small intestine، بيبدأ يشتغل فيه ال
+
+528
+00:39:10,970 --> 00:39:13,830
+small intestine، and then spread to the mesenteric
+
+529
+00:39:13,830 --> 00:39:15,990
+lymph node، طبعا ال lymph node اللي موجودة في
+
+530
+00:39:15,990 --> 00:39:21,500
+الأمعاقهي أكبر كمية من جهاز المناعة الموجودة في
+
+531
+00:39:21,500 --> 00:39:24,340
+وين؟ في الـ intestinal tract، بيمثلها الـ
+
+532
+00:39:24,340 --> 00:39:28,960
+mesenteric lymph nodes، where it multiplies again،
+
+533
+00:39:28,960 --> 00:39:32,340
+it then enters the bloodstream and is transmitted
+
+534
+00:39:32,340 --> 00:39:36,640
+to certain internal organs where it multiplies
+
+535
+00:39:36,640 --> 00:39:40,770
+againلم يكتفي بوجوده في الـ intestinal tract بل
+
+536
+00:39:40,770 --> 00:39:44,930
+ذهب إلى باقي أنحاء الجسم وهذا معشر على أنه ال
+
+537
+00:39:44,930 --> 00:39:48,490
+viruses ممكن تكون localized وممكن تكون أيضا
+
+538
+00:39:48,490 --> 00:39:49,450
+disseminated
+
+539
+00:39:52,940 --> 00:39:54,960
+الفيروس اللي بيتكلم عنه اللي هو المزيد اللي بيتكلم
+
+540
+00:39:54,960 --> 00:39:57,540
+عنه مين احنا عن ال ال ال ال ال ال ال ال ال ال ال
+
+541
+00:39:57,540 --> 00:39:57,740
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+542
+00:39:57,740 --> 00:39:58,340
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+543
+00:39:58,340 --> 00:39:58,380
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+544
+00:39:58,380 --> 00:39:58,480
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+545
+00:39:58,480 --> 00:40:05,380
+ال ال ال ال ال ال اله هو
+
+546
+00:40:05,380 --> 00:40:12,780
+هد
+
+547
+00:40:14,070 --> 00:40:19,390
+طبعا إذا وصل هناك ودمر هذا النتيج العصري المهم من
+
+548
+00:40:19,390 --> 00:40:22,570
+هنا بيحدث اللي هو الشرل أو الـ Paralysis Viral
+
+549
+00:40:22,570 --> 00:40:25,210
+replication in the gastrointestinal tract result
+
+550
+00:40:25,210 --> 00:40:29,190
+in the presence of poliovirus in the feces فبتالي
+
+551
+00:40:29,190 --> 00:40:33,210
+عملية ال transmission بتكون fecal oral حتى وإذا
+
+552
+00:40:33,210 --> 00:40:37,260
+كان المرض عصبي إلا أن الميكروبقدرته على التكاثر
+
+553
+00:40:37,260 --> 00:40:40,180
+اللي هو الفيروس ع في الـ intestine يجعل من انتقاله
+
+554
+00:40:40,180 --> 00:40:44,720
+عبر البراز أو عبر الفيكل oral route انتقال مهم
+
+555
+00:40:44,720 --> 00:40:46,660
+ولمرة جاي ان شاء الله نكمل المحاضرة
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/5JmKrldRkA4_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/5JmKrldRkA4_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..67ad319f55569ff8f70c3ed9d59a67a6fb5bc982
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/5JmKrldRkA4_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 4641, "start": 20.89, "end": 46.41, "text": "بسم الله الرحمن الرحيم الموضوع الجديد اليوم اللي هو ال viral pathogenesis كيف لذاك الفيروس الصغير الذي لايمتلك من مقومات الحياة إلا قدرة على التكاثر كيف له أن يحدث أمراض قد تتراوح من أمراض بسيطة وسهلة إلى أمراض خطيرة جدا هذا مثلا اتعرف عليه ان شاء الله في محاضرتنا اليوم viral pathogenesis", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 9673, 2407, 11242, 45367, 25724, 16254, 3215, 45595, 20498, 13672, 1829, 31439, 2423, 16132, 3100, 8799, 9374, 9122, 33911, 5296, 15730, 4117, 27188, 13546, 41779, 31767, 17082, 13546, 43527, 20193, 32640, 2655, 23275, 9154, 3714, 4587, 20498, 9307, 21542, 25528, 3660, 11933, 15040, 12174, 3215, 25720, 15844, 16712, 4117, 5718, 104, 2288, 9122, 33911, 46740, 14739, 7251, 24401, 12984, 5551, 29973, 46958, 12174, 3215, 6055, 2655, 23557, 2407, 5016, 9154, 5551, 29973, 46958, 4724, 3794, 1829, 9566, 3660, 46952, 3224, 37977, 30731, 5551, 29973, 46958, 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124.51, "end": 124.71, "word": " انها", "probability": 0.35858154296875}, {"start": 124.71, "end": 125.05, "word": " مجموعة", "probability": 0.93701171875}, {"start": 125.05, "end": 125.19, "word": " من", "probability": 0.9912109375}, {"start": 125.19, "end": 125.97, "word": " الفيروسات", "probability": 0.9600830078125}, {"start": 125.97, "end": 126.49, "word": " نسميها", "probability": 0.7994384765625}, {"start": 126.49, "end": 127.87, "word": " oncoviruses", "probability": 0.64739990234375}], "temperature": 1.0}, {"id": 6, "seek": 15728, "start": 129.38, "end": 157.28, "text": "Or Fusion Or Transformation To Malignancy الإحتمال الرابع اللى يظهر عليها أي إشارات خارجية كلمة apparent يعني ظاهرية تمام أو حتى ال functional change يعني مش شايفين فيها تغير وظيفة لهذه الخلايا كيف لخلية أن تموت عندما تصاب ب فيروس؟", "tokens": [21520, 36721, 1610, 6531, 8663, 1407, 5746, 788, 6717, 33688, 33753, 2304, 6027, 34892, 16758, 3615, 13672, 7578, 7251, 19913, 3224, 2288, 25894, 11296, 36632, 11933, 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موجود وهو ايقاف تصنيع ال macro molecules، ايش يعني macro molecules؟ يعني proteins، يعني carbohydrates، يعني DNA، يعني lipids، هذه هي ال macro molecules", "tokens": [10721, 4587, 2407, 7578, 1975, 33753, 2304, 6027, 37037, 2407, 42963, 33753, 2304, 6027, 13672, 7578, 46811, 11778, 23557, 14851, 3224, 1975, 2407, 11331, 36520, 8315, 15844, 4467, 16472, 3224, 11331, 38436, 38436, 3714, 29245, 23328, 37037, 2407, 1975, 1829, 4587, 31845, 6055, 9381, 22653, 3615, 2423, 18887, 13093, 12399, 1975, 1829, 8592, 37495, 22653, 18887, 13093, 22807, 37495, 22653, 15577, 12399, 37495, 22653, 36817, 12399, 37495, 22653, 8272, 12399, 37495, 22653, 8280, 3742, 12399, 29538, 39896, 2423, 18887, 13093], "avg_logprob": -0.17187499705656076, "compression_ratio": 1.7010309278350515, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 157.98, "end": 158.52, "word": "أقوى", "probability": 0.9169921875}, {"start": 158.52, "end": 159.3, "word": " احتمال", "probability": 0.9608154296875}, {"start": 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"probability": 0.960205078125}, {"start": 170.72, "end": 171.7, "word": " carbohydrates،", "probability": 0.878173828125}, {"start": 171.7, "end": 171.88, "word": " يعني", "probability": 0.974853515625}, {"start": 171.88, "end": 172.58, "word": " DNA،", "probability": 0.90478515625}, {"start": 172.58, "end": 172.9, "word": " يعني", "probability": 0.9755859375}, {"start": 172.9, "end": 173.72, "word": " lipids،", "probability": 0.8128255208333334}, {"start": 173.72, "end": 173.86, "word": " هذه", "probability": 0.69580078125}, {"start": 173.86, "end": 174.06, "word": " هي", "probability": 0.93505859375}, {"start": 174.06, "end": 174.18, "word": " ال", "probability": 0.8515625}, {"start": 174.18, "end": 174.52, "word": " macro", "probability": 0.9794921875}, {"start": 174.52, "end": 175.36, "word": " molecules", "probability": 0.818359375}], "temperature": 1.0}, {"id": 8, "seek": 20037, "start": 176.21, "end": 200.37, "text": "إذا من من هذه ال macro molecules التي يستطيع الفيروس أن 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"probability": 0.6771240234375}, {"start": 219.73, "end": 220.31, "word": " اتوقف", "probability": 0.818603515625}, {"start": 220.31, "end": 221.03, "word": " لـ", "probability": 0.724853515625}, {"start": 221.03, "end": 221.41, "word": " Protein", "probability": 0.912109375}, {"start": 221.41, "end": 221.95, "word": " Synthesis", "probability": 0.949951171875}, {"start": 221.95, "end": 222.15, "word": " في", "probability": 0.947265625}, {"start": 222.15, "end": 222.61, "word": " خلينا", "probability": 0.8204752604166666}, {"start": 222.61, "end": 222.99, "word": " ما", "probability": 0.298095703125}, {"start": 222.99, "end": 223.19, "word": " الذي", "probability": 0.6865234375}, {"start": 223.19, "end": 223.77, "word": " سيحدث", "probability": 0.987060546875}, {"start": 223.77, "end": 224.55, "word": " تذكروا", "probability": 0.954833984375}, {"start": 224.55, "end": 225.25, "word": " ان", "probability": 0.73876953125}, {"start": 225.25, "end": 225.95, "word": " كل", "probability": 0.92724609375}, {"start": 225.95, "end": 227.13, "word": " الانزينات", "probability": 0.7697265625}, {"start": 227.13, "end": 227.47, "word": " في", "probability": 0.96337890625}, {"start": 227.47, "end": 228.07, "word": " الخلية", "probability": 0.935546875}, {"start": 228.07, "end": 228.69, "word": " هي", "probability": 0.78515625}, {"start": 228.69, "end": 229.49, "word": " Proteinات", "probability": 0.7285970052083334}], "temperature": 1.0}, {"id": 10, "seek": 24288, "start": 230.02, "end": 242.88, "text": "إذا توقفت الانزيمات، اللي هي البروتينات، عن الإنتاج، عن العمل، عن أداء وظائفها، فانا بتوقع حتى ال DNA يبطل يصير له synthesis، لكن بالأساس", "tokens": [28814, 15730, 6055, 30543, 5172, 2655, 2423, 7649, 11622, 32640, 9307, 12399, 13672, 1829, 39896, 2423, 26890, 35473, 9957, 9307, 12399, 18871, 33688, 29399, 26108, 12399, 18871, 18863, 42213, 12399, 18871, 5551, 3215, 16606, 4032, 19913, 16373, 5172, 11296, 12399, 6156, 7649, 995, 39894, 30543, 3615, 11331, 49975, 2423, 8272, 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"end": 708.16, "word": " glycoproteins", "probability": 0.85517578125}, {"start": 708.16, "end": 708.8, "word": " يشبكهم", "probability": 0.858642578125}, {"start": 708.8, "end": 708.92, "word": " مع", "probability": 0.97607421875}, {"start": 708.92, "end": 709.34, "word": " مين؟", "probability": 0.94091796875}, {"start": 709.34, "end": 709.64, "word": " مع", "probability": 0.95703125}, {"start": 709.64, "end": 709.8, "word": " ال", "probability": 0.955078125}, {"start": 709.8, "end": 710.0, "word": " cell", "probability": 0.94921875}, {"start": 710.0, "end": 710.44, "word": " membrane", "probability": 0.93505859375}, {"start": 710.44, "end": 710.74, "word": " تبقى", "probability": 0.74957275390625}, {"start": 710.74, "end": 711.08, "word": " الخلية", "probability": 0.8527018229166666}, {"start": 711.08, "end": 711.64, "word": " المصابة", "probability": 0.9818115234375}], "temperature": 1.0}, {"id": 31, "seek": 73694, "start": 712.16, "end": 736.94, "text": "هذه الـ Glycoprotein هي مش our own it is a virus Glycoprotein ولهذه المناعة تبعنا احنا بيبقى عامل زي شرطة المرور بيمروا على الخلايا انت self self self self اه هذه الخلية في عليها abnormal proteins يبقى هذا مش self attack اهجم", "tokens": [3224, 24192, 2423, 39184, 460, 356, 13084, 81, 1370, 259, 39896, 37893, 527, 1065, 309, 307, 257, 5752, 460, 356, 13084, 81, 1370, 259, 4032, 1211, 3224, 24192, 9673, 8315, 27884, 6055, 3555, 3615, 8315, 1975, 5016, 8315, 4724, 1829, 3555, 4587, 7578, 6225, 10943, 1211, 30767, 1829, 13412, 2288, 9566, 3660, 9673, 2288, 13063, 4724, 1829, 29973, 14407, 15844, 33962, 15040, 25528, 16472, 2655, 2698, 2698, 2698, 2698, 1975, 3224, 29538, 33962, 1211, 10632, 8978, 25894, 11296, 32847, 15577, 7251, 3555, 4587, 7578, 23758, 37893, 2698, 2690, 1975, 3224, 7435, 2304], "avg_logprob": -0.24714381079519948, "compression_ratio": 1.635, "no_speech_prob": 0.0, "words": [{"start": 712.16, "end": 712.52, "word": "هذه", "probability": 0.6505126953125}, {"start": 712.52, "end": 712.62, "word": " 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{"start": 734.92, "end": 735.08, "word": " مش", "probability": 0.98974609375}, {"start": 735.08, "end": 735.48, "word": " self", "probability": 0.94091796875}, {"start": 735.48, "end": 736.04, "word": " attack", "probability": 0.8798828125}, {"start": 736.04, "end": 736.94, "word": " اهجم", "probability": 0.9039306640625}], "temperature": 1.0}, {"id": 32, "seek": 76317, "start": 737.87, "end": 763.17, "text": "فاللي بدمر الخلايا تحت الـ organ المصاب بفيروس لا يعطي اي morphologic ولا functional changes اللي بدمرها غالبا من جهاز المناع وهذا ما يحدث في التهاب الكبد الوبائي B وC لأن الفيروس نفسه ما بيحدث اي change لكن اللي بيحدث ال change هذا من جهاز المناع", "tokens": [5172, 6027, 20292, 47525, 29973, 33962, 15040, 25528, 6055, 33753, 2423, 39184, 1798, 9673, 9381, 16758, 4724, 5172, 13546, 41779, 20193, 37495, 9566, 1829, 1975, 1829, 25778, 36661, 49429, 11745, 2962, 13672, 1829, 47525, 29973, 11296, 32771, 6027, 3555, 995, 9154, 10874, 3224, 31377, 9673, 8315, 3615, 37037, 15730, 19446, 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{"start": 757.81, "end": 758.73, "word": " الفيروس", "probability": 0.865234375}, {"start": 758.73, "end": 759.13, "word": " نفسه", "probability": 0.9698893229166666}, {"start": 759.13, "end": 759.25, "word": " ما", "probability": 0.826171875}, {"start": 759.25, "end": 759.65, "word": " بيحدث", "probability": 0.88720703125}, {"start": 759.65, "end": 759.79, "word": " اي", "probability": 0.772705078125}, {"start": 759.79, "end": 760.23, "word": " change", "probability": 0.62744140625}, {"start": 760.23, "end": 760.69, "word": " لكن", "probability": 0.53564453125}, {"start": 760.69, "end": 760.83, "word": " اللي", "probability": 0.964599609375}, {"start": 760.83, "end": 761.07, "word": " بيحدث", "probability": 0.97119140625}, {"start": 761.07, "end": 761.21, "word": " ال", "probability": 0.8154296875}, {"start": 761.21, "end": 761.39, "word": " change", "probability": 0.50927734375}, {"start": 761.39, "end": 761.55, "word": " هذا", "probability": 0.432373046875}, {"start": 761.55, "end": 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"text": "الـ Respiratory Tract ما زلنا فيها Cytomegalovirus، Micelles Virus، Mumps Virus، Rubella Virus، كل ما دول اللي رسمناهم من المحاضرة السابقة لما تكلمنا عن تصنيف اللي هو الـ RNA Viruses وقولنا MMR اللي هو ال vaccine، Micelles, Mumps and Rubella طبعا الـ Hantavirus بسبب نيمونيا والأدينوفيروس أيضا بسبب النيمونيا، هذا لا يعني", "tokens": [6027, 39184, 5015, 9501, 4745, 1765, 578, 19446, 30767, 1211, 8315, 8978, 11296, 383, 4328, 423, 9800, 5179, 9619, 12399, 376, 573, 19126, 39790, 12399, 376, 16951, 39790, 12399, 497, 1977, 3505, 39790, 12399, 28242, 19446, 11778, 12610, 13672, 1829, 12602, 38251, 8315, 16095, 9154, 9673, 5016, 46958, 25720, 21136, 16758, 28671, 5296, 15042, 6055, 4117, 19528, 8315, 18871, 6055, 9381, 22653, 5172, 13672, 1829, 31439, 2423, 39184, 22484, 7566, 8355, 4032, 39648, 8315, 376, 21173, 13672, 1829, 31439, 2423, 7007, 12399, 376, 573, 19126, 11, 376, 16951, 293, 497, 1977, 3505, 23032, 3555, 3615, 995, 2423, 39184, 389, 394, 10868, 4724, 35457, 3555, 8717, 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الفيروسي طبعا قد تقابل في النسبة تلك اللتي تسببها البكتيرا ليس مسترد كوكاس بيو جينز إذا ال respiratory tract", "tokens": [3224, 1829, 6156, 47432, 6055, 23275, 13672, 31371, 6055, 35457, 3555, 29538, 27188, 13546, 41779, 9307, 37495, 22653, 50113, 15040, 8032, 1863, 3215, 5172, 1863, 50113, 6027, 15844, 472, 4752, 7008, 538, 257, 614, 268, 5179, 9619, 24525, 2304, 3224, 2423, 39184, 43097, 44381, 3714, 2288, 20449, 7649, 995, 8978, 9673, 5016, 46958, 25720, 21136, 16758, 28671, 16472, 11296, 39894, 25957, 1211, 903, 822, 872, 16074, 5296, 15042, 12174, 12610, 8315, 23275, 14407, 16472, 3224, 39896, 9154, 5551, 8592, 3224, 2288, 47524, 3555, 3555, 9307, 16712, 1863, 3794, 12610, 995, 36081, 3794, 5296, 3215, 7578, 16247, 9566, 5172, 6027, 9154, 28239, 45367, 27188, 13546, 41779, 1829, 23032, 3555, 3615, 995, 12174, 3215, 6055, 4587, 16758, 1211, 8978, 28239, 35457, 3660, 6055, 23275, 13672, 31371, 6055, 35457, 3555, 11296, 29739, 4117, 2655, 13546, 995, 32239, 3794, 3714, 14851, 2288, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/7XJrhnztack.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/7XJrhnztack.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9ee15827e5147d597acae39d47a798ad25a238ad
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/7XJrhnztack.srt
@@ -0,0 +1,2119 @@
+1
+00:00:21,060 --> 00:00:24,480
+بسم الله الرحمن الرحيم نكمل إن شاء الله موضوع الـ
+
+2
+00:00:24,480 --> 00:00:27,920
+structure of the viruses وبدأنا بالحديث المحاضرة
+
+3
+00:00:27,920 --> 00:00:31,740
+السابقة عن الـ viral nucleic acid وقلنا إنها بتتميز
+
+4
+00:00:31,740 --> 00:00:37,500
+بالفيروسات بأنه هي الوحيدة التي يعني يمكن القول
+
+5
+00:00:37,500 --> 00:00:42,790
+بأنه هي تمتلك genome مكون من RNA وهي الوحيدة أيضًا
+
+6
+00:00:42,790 --> 00:00:45,970
+التي تكون من جينوم أو البعض منها بتكون من جينوم
+
+7
+00:00:45,970 --> 00:00:50,450
+محتوى على single-stranded DNA أو double-stranded
+
+8
+00:00:50,450 --> 00:00:54,730
+RNA يعني فيه .. يعني تفرد في الجينوم تبع الفيروسات
+
+9
+00:00:54,730 --> 00:00:57,730
+إذا الـ DNA ممكن يكون double-stranded ممكن يكون
+
+10
+00:00:57,730 --> 00:01:01,010
+single-stranded الـ RNA ممكن يكون double-stranded
+
+11
+00:01:01,010 --> 00:01:04,510
+ممكن يكون أيضًا single-stranded في كمان كتير نقطة
+
+12
+00:01:04,510 --> 00:01:10,610
+مهمة أن الـ DNA ممكن يكون linear زي الـ Eukaryotes
+
+13
+00:01:10,610 --> 00:01:14,770
+أو الـ Circular زي الـ Prokaryotes هذه كمان نقطة
+
+14
+00:01:14,770 --> 00:01:22,090
+مهمة الآن المادة الوراثية قد تكون قطعة واحدة ومعظم
+
+15
+00:01:22,090 --> 00:01:25,670
+أو كل الـ DNA viruses على سبيل المثال قطعة واحدة
+
+16
+00:01:25,670 --> 00:01:30,290
+بينما الـ RNA viruses قد تكون قطعة وقد تكون مكونة
+
+17
+00:01:30,290 --> 00:01:34,150
+من عدة قطع وذكرنا مثال عليها مثل الـ influenza
+
+18
+00:01:34,150 --> 00:01:38,950
+virus والـ rotavirus segmented بمعنى أن المادة
+
+19
+00:01:38,950 --> 00:01:43,390
+الوراثية عبارة عن أجزاء مختلفة الـ influenza virus
+
+20
+00:01:43,390 --> 00:01:51,110
+ثمان قطع ثمان قطع كل الفيروسات تعتبر haploid بمعنى
+
+21
+00:01:51,110 --> 00:01:54,530
+they contain only one single copy of the genome ما
+
+22
+00:01:54,530 --> 00:01:58,550
+عدا الـ .. أو اللي هي الـ retrovirus family اللي هي
+
+23
+00:01:58,550 --> 00:02:04,730
+بيتميزها الـ HIV مكونة من اثنين نسخة من نفس الجينوم
+
+24
+00:02:04,730 --> 00:02:08,270
+وبالتالي بنسميها diploid وهذه طبعًا غريبة من غرائب
+
+25
+00:02:08,270 --> 00:02:09,870
+أيضًا اللي هو الفيروسات
+
+26
+00:02:12,640 --> 00:02:16,440
+بنسبه لـ capsid الـ capsid هي الـ housing أو
+
+27
+00:02:16,440 --> 00:02:21,480
+الغلاف اللي بيبقى جوا بيكون فيه المادة الوراثية و
+
+28
+00:02:21,480 --> 00:02:27,500
+الـ capsid عبارة عن protein coat مكون من capsomers
+
+29
+00:02:27,500 --> 00:02:32,000
+و الـ capsomers قلنا هي وحدات بنائية أو monomers
+
+30
+00:02:32,000 --> 00:02:36,160
+غالباً والمرة الماضية تحدثنا عنها لكن هنتكلم عنها
+
+31
+00:02:36,160 --> 00:02:39,760
+برضه بشيء من التفصيل اليوم حتى نؤكد على حقيقة
+
+32
+00:02:39,760 --> 00:02:46,160
+وأهمية بناء الكبسيد كاملة من نوع واحد من البروتينات
+
+33
+00:02:46,160 --> 00:02:52,360
+أو من صنف واحد من البروتينات الكبسومر عبارة عن تحت
+
+34
+00:02:52,360 --> 00:02:56,500
+الميكروسكوب بنلاقيها عبارة عن كُريات وهذه الكوريات
+
+35
+00:02:56,500 --> 00:03:02,590
+فيها central hole يعني ثقب مركزي ويظن العلماء بأن
+
+36
+00:03:02,590 --> 00:03:07,410
+هذا الثقب المركزي أساسي في عملية الارتباط أو ما
+
+37
+00:03:07,410 --> 00:03:12,070
+يسمى بالـ self-assembly اللي ذكرناه سابقًا وهنذكره
+
+38
+00:03:12,070 --> 00:03:16,730
+كمان شوية لاحقًا، إذن هي عبارة عن كورية ومحتوي على
+
+39
+00:03:16,730 --> 00:03:23,030
+Central Hall الـ Structure composed of nucleic acid
+
+40
+00:03:23,030 --> 00:03:28,890
+و خارجه الكبسيد بنسميه نوكليو كبسيد والنوكليو
+
+41
+00:03:28,890 --> 00:03:33,710
+كبسيد قد تكون هي الفيروس بمعنى أن في فيروسات
+
+42
+00:03:33,710 --> 00:03:38,050
+لا تمتلك إلا النوكليو كبسيد والكبسيد تبعتها
+
+43
+00:03:38,050 --> 00:03:44,790
+وبالتالي هي بتكون whole virion one single virus
+
+44
+00:03:44,790 --> 00:03:51,250
+إذا النوكليو كبسيد قد تكون فيروس كامل الـ
+
+45
+00:03:51,250 --> 00:03:55,630
+Arrangement وطبيعة الـ Capsomers هي اللي بتحدد الـ
+
+46
+00:03:55,630 --> 00:03:58,870
+Geometric Symmetry للفيروسات إيش يعني الـ
+
+47
+00:03:58,870 --> 00:04:02,510
+Geometric Symmetry؟ يعني مثلًا في عندي في اللوحة زي
+
+48
+00:04:02,510 --> 00:04:07,330
+ما أنتم شايفين في الصورة أعلى اللوحة عندي كورية
+
+49
+00:04:07,330 --> 00:04:14,650
+مكونة من مثلثات هذه المثلثات عبارة عن عشرين مثلثًا
+
+50
+00:04:14,650 --> 00:04:20,570
+بيسموها عشروني الوجوه عشروني الوجوه أو بالانجليزي
+
+51
+00:04:20,570 --> 00:04:25,490
+بنسميها icosahedral بينما
+
+52
+00:04:25,490 --> 00:04:32,530
+بالنسبة للجزء السفلي عبارة عن spiral arrangement
+
+53
+00:04:34,080 --> 00:04:37,020
+ففينا شكلين أساسياً في الفيروسات إما الـ
+
+54
+00:04:37,020 --> 00:04:42,200
+Icosahedral أو الـ Spiral أو الـ Helical
+
+55
+00:04:42,200 --> 00:04:47,480
+Arrangement عادى ذلك بنسميه Complex، بنسميه
+
+56
+00:04:47,480 --> 00:04:51,300
+Complex وغالباً الـ Complex لا تمتلك أي من الشكلين
+
+57
+00:04:51,300 --> 00:04:54,940
+أو تمتلك الشكلين مع بعض في نفس التركيب مثلًا
+
+58
+00:04:55,510 --> 00:04:58,850
+البكتيريو فاج وأنا أوردت لكم صورة منه المرة الماضية
+
+59
+00:04:58,850 --> 00:05:02,870
+الرأس تبعه عبارة عن ايكوزاهيدرال لكن الـ cooler
+
+60
+00:05:02,870 --> 00:05:07,430
+تبعته عبارة عن spiral أو helical فبالتالي بنسميه هذا
+
+61
+00:05:07,430 --> 00:05:13,270
+أيضًا إيه complex في حاجة حلوة ممكن نعممها من الآن
+
+62
+00:05:13,270 --> 00:05:19,730
+أن كل الـ human viruses اللي بتمتلك helical
+
+63
+00:05:19,730 --> 00:05:24,390
+arrangement أو symmetry كلها enveloped كلها
+
+64
+00:05:24,390 --> 00:05:29,990
+enveloped بينما اللي بتمتلك icosahedral
+
+65
+00:05:29,990 --> 00:05:33,270
+arrangement قد تكون enveloped وقد لا تكون
+
+66
+00:05:33,270 --> 00:05:37,990
+enveloped وضعت صورة جدا كل الـ helical enveloped
+
+67
+00:05:37,990 --> 00:05:43,190
+لكن ليس كل الـ icosahedral enveloped في بعض منها
+
+68
+00:05:43,190 --> 00:05:51,510
+هيك وبعض منها مش enveloped ما هي المزايا التي يحصل
+
+69
+00:05:51,510 --> 00:05:58,070
+عليها الفيروس من بناء من بناء الـCapsid كلها من
+
+70
+00:05:58,070 --> 00:06:03,690
+الـCapsomer الواحد تخيلوا أنا بدرس خمس مساقات في
+
+71
+00:06:03,690 --> 00:06:09,650
+الجامعة وكل مساق بدي أحمله Flash تمام؟ يبقى كم
+
+72
+00:06:09,650 --> 00:06:14,070
+Flash هأحمل؟ خمس Flashes ولو كان حجم الـFlash كبير
+
+73
+00:06:14,070 --> 00:06:20,730
+تمام؟ بدي يعني أحد يساعدني في الموضوع طيب تخيل ثاني
+
+74
+00:06:20,730 --> 00:06:24,390
+أن كل المساقات الخمسة محمولين على مين؟ على Flash
+
+75
+00:06:24,390 --> 00:06:28,890
+واحد أعتقد أن هيك أنا خففت مين؟ حمل .. حمل من
+
+76
+00:06:28,890 --> 00:06:33,130
+ذاكرتي .. حمل من ذاكرتي للـ memory .. الآن لما
+
+77
+00:06:33,130 --> 00:06:38,270
+بنقول protein .. protein يعني أصله جاي من جين لما
+
+78
+00:06:38,270 --> 00:06:41,750
+يكون protein واحد يعني جين واحد اثنين protein
+
+79
+00:06:41,750 --> 00:06:44,910
+اثنين جين ثلاثة protein أربعة جين
+
+80
+00:06:47,580 --> 00:06:53,120
+الفكرة أن أنا أبني كل البيت اللي هو الكبسيد من الـ
+
+81
+00:06:53,120 --> 00:06:56,080
+protein الواحد يعني أنا بدي gene واحد لبناء البيت
+
+82
+00:06:56,080 --> 00:07:00,480
+أليس ذلك إنجازًا كبيرًا المادة الوراثية اللي هأحملها
+
+83
+00:07:00,480 --> 00:07:05,080
+لهذا البيت فقط gene واحد هذه نقطة كثير مهمة it
+
+84
+00:07:05,080 --> 00:07:10,320
+reduces the need for genetic information رقم اثنين
+
+85
+00:07:10,320 --> 00:07:15,780
+المادة الواحدة زي المغناطيسات الكروية induces أو
+
+86
+00:07:15,780 --> 00:07:20,220
+promotes self-assembly اللي هو التجميع الذاتي إيش
+
+87
+00:07:20,220 --> 00:07:26,160
+يعني التجميع الذاتي؟ كمان مرة مجموعة من الكوريات
+
+88
+00:07:26,160 --> 00:07:32,280
+رميناها على طرف من الأطراف وعندما التقت هذه
+
+89
+00:07:32,280 --> 00:07:39,100
+الكوريات بدأت تتسلق فوق بعضها البعض وصارت تعمل شكل
+
+90
+00:07:39,100 --> 00:07:45,320
+معين هل أنا ساهمت في هذا الشكل؟ بأي وسيلة من
+
+91
+00:07:45,320 --> 00:07:49,840
+الوسائل نفترض أن احنا بنبني بيت إيش بدنا؟ block
+
+92
+00:07:50,420 --> 00:07:53,080
+والـ block بدنا نحط بين الـ block والـ block احنا
+
+93
+00:07:53,080 --> 00:07:57,580
+نحط سمنت لاصق وبدنا واحد يحط الـ block مظبوط ولا
+
+94
+00:07:57,580 --> 00:08:04,100
+لأ؟ بدنا الأسمنت اعتبره الطاقة وبدنا البناء اللي
+
+95
+00:08:04,100 --> 00:08:07,480
+هو اللي بده يبني اعتبره الـ enzyme تمام؟ طب لما
+
+96
+00:08:07,480 --> 00:08:12,440
+يكون عندي حائط يبنى لوحده لا بده يبنى ولا بده
+
+97
+00:08:19,280 --> 00:08:24,440
+السيلف أسيمبلي بتوفر على الفيروس كمان مرة اللي هو
+
+98
+00:08:24,440 --> 00:08:28,120
+الـ enzymes والـ energy واحد بيقول لي طيب الـ enzymes
+
+99
+00:08:29,130 --> 00:08:31,990
+وإيش ليش ما يكون فيه enzyme يعني الـ enzyme هو
+
+100
+00:08:31,990 --> 00:08:35,050
+protein والـ protein بده يكون gene برضه صح ولا لأ
+
+101
+00:08:35,050 --> 00:08:38,950
+يبقى وفرنا أيضًا genetic information إذا مهم جدًا
+
+102
+00:08:38,950 --> 00:08:43,470
+نفهم أن هذه الوحدات البنائية اللي اسمها capsomers
+
+103
+00:08:43,470 --> 00:08:48,370
+ممتازة جدًا للفيروسات بل رائعة واستطاع العلماء أن
+
+104
+00:08:48,370 --> 00:08:54,720
+يشكلوا أو يكونوا فيروسات فقط من وضع capsomers في
+
+105
+00:08:54,720 --> 00:08:58,460
+أنبوبة بالإضافة إلى مادة وراثية self-assembly
+
+106
+00:08:58,460 --> 00:09:03,140
+تجميع ذاتي لا أنزيمات ولا طاقة تم احتياجها وتكون
+
+107
+00:09:03,140 --> 00:09:08,140
+فيروس كامل في هذه الحالة نتكلم شوية عن الـ viral
+
+108
+00:09:08,140 --> 00:09:12,820
+proteins وهي قضية مهمة جدًا جدًا في الـ virology ما
+
+109
+00:09:12,820 --> 00:09:18,260
+هي وظائف البروتينات في الفيروسات ولا تظنوا أنني
+
+110
+00:09:18,260 --> 00:09:23,880
+أتحدث عن فيروس بعينه وإنما أتحدث عن كل الفيروسات
+
+111
+00:09:23,880 --> 00:09:28,160
+بعض الفيروسات قد تمتلك هذه الصفات والبعض الآخر قد
+
+112
+00:09:28,160 --> 00:09:31,120
+لا يمتلكها زي ما كنا نتحدث عن البكتيريا ونقول
+
+113
+00:09:31,120 --> 00:09:34,980
+فلاجلة مثلًا في بكتيريا فيها فلاجلة وبكتيريا ما فيها
+
+114
+00:09:34,980 --> 00:09:38,720
+أش فلاجلة لكن في شكل عام كنا نتكلم عن الفلاجلة
+
+115
+00:09:38,720 --> 00:09:44,720
+واحدة من أهم وظائف البروتينات في الفيروسات is to
+
+116
+00:09:44,720 --> 00:09:48,380
+protect ما هنكون نفسنا متكلم قبل قليل إنه الـ
+
+117
+00:09:48,380 --> 00:09:52,440
+Capsid هي اللي بتحمل مادة الوراثية إذا to protect
+
+118
+00:09:52,440 --> 00:09:56,380
+the nucleic material رقم اثنين Mediate the
+
+119
+00:09:56,380 --> 00:10:01,320
+Attachment زي ما في البكتيريا بالضبط لا يمكن بأي
+
+120
+00:10:01,320 --> 00:10:05,520
+حال من الأحوال للبكتيريا أن تحدث عدوى إلا من خلال
+
+121
+00:10:05,520 --> 00:10:10,390
+أول خطوة اسمها Attachment برضه الفيروس محتاج
+
+122
+00:10:10,390 --> 00:10:15,450
+attachment كيف له أن يلتصق من خلال الـ proteinات
+
+123
+00:10:15,450 --> 00:10:20,450
+اللي موجودة على السطح تبعه سواء كانت الـ capsid أو
+
+124
+00:10:20,450 --> 00:10:23,930
+كانت الـ envelope اللي هنتكلم عنه لاحقًا لكن هي في
+
+125
+00:10:23,930 --> 00:10:29,290
+الآخر proteinات طيب لماذا هناك فيروسات تصيب
+
+126
+00:10:29,290 --> 00:10:35,410
+الحيوان، وهناك فيروسات تصيب على سبيل المثال النبات
+
+127
+00:10:35,410 --> 00:10:38,090
+specificity
+
+128
+00:10:39,730 --> 00:10:45,490
+بنسميها Species Specificity بتصيب العصافير، بتصيبش 
+
+129
+00:10:45,490 --> 00:10:52,930
+البط، العصفور طير، والبط طير، لكن Species مختلفة، ما 
+
+130
+00:10:52,930 --> 00:10:57,150
+الذي جعلها تصيب وجود بروتينات لها مستقبلات في هذا 
+
+131
+00:10:57,150 --> 00:11:01,530
+الطير، وليس لها مستقبلات في ذلك الطير، إذن Species
+
+132
+00:11:01,530 --> 00:11:08,490
+Specificity، لماذا تصيب الكبد ولا تصيب القلب؟ كمان 
+
+133
+00:11:08,490 --> 00:11:12,750
+مرة لها Receptor للبروتينات التابعة لها في الكبد، وليس
+
+134
+00:11:12,750 --> 00:11:16,690
+لها Receptor على عضلة القلب، لذا نطلع على
+
+135
+00:11:16,690 --> 00:11:21,250
+الاستنتاج ونشوف إن في عندي حاجتين، Species and
+
+136
+00:11:21,250 --> 00:11:25,750
+Organ Specificity، الاثنتين، بحددها برضه البروتينات
+
+137
+00:11:27,230 --> 00:11:32,150
+نقطة كمان ثالثة مهمة لا تقل أهمية وهي الانتيجينات
+
+138
+00:11:32,150 --> 00:11:38,350
+proteins acts as antigens، وما دام they act as 
+
+139
+00:11:38,350 --> 00:11:43,350
+antigen، يبقى إيش الحكمة من ورائها أن جسمنا هيكون
+
+140
+00:11:43,350 --> 00:11:47,790
+أجسامًا مضادة، بغرض ماذا؟ to neutralize، إيش يعني
+
+141
+00:11:47,790 --> 00:11:53,390
+neutralize؟ هذا الـ antigen، هذا الـ antigen، ويرتبط 
+
+142
+00:11:54,280 --> 00:11:58,200
+مع الـ Receptor، يرتبط معه الـ Receptor، الآن ما في
+
+143
+00:11:58,200 --> 00:12:02,920
+بينهم أي حائل يمنعهم من الارتباط، وجود Antibody
+
+144
+00:12:02,920 --> 00:12:08,780
+يرتبط فيه الـ Antigen، بيعمل نوع من المعادلة لهذا
+
+145
+00:12:08,780 --> 00:12:12,320
+الـ Antigen، بحيث أنه يمنعه من الارتباط منين؟ بالـ
+
+146
+00:12:12,320 --> 00:12:15,500
+Receptor، يبقى فيه أن الآن صار في استهداف
+
+147
+00:12:15,500 --> 00:12:19,240
+للبروتينات اللي هي الـ Antigen من جهاز المناعة حتى
+
+148
+00:12:19,240 --> 00:12:23,710
+يمنعها من الارتباط، منعها من الارتباط هو منع للعدوى
+
+149
+00:12:23,710 --> 00:12:26,850
+لأن احنا قلنا أول خطوة في العدوى هو الـ Attachment
+
+150
+00:12:26,850 --> 00:12:30,190
+وبالتالي بيبنيناها من اللي هو الـ Attachment، طبعًا الـ
+
+151
+00:12:30,190 --> 00:12:33,330
+… الـ … الـ protein، كـ أنتجينات تم الـ induction للـ
+
+152
+00:12:33,330 --> 00:12:39,250
+immune response، وده أمر طبيعي، بعض الـ enzyme … بعض
+
+153
+00:12:39,250 --> 00:12:44,150
+الـ protein، احنا في الـ … الـ … الـ في الـ virus 
+
+154
+00:12:44,150 --> 00:12:48,770
+بتكون structural بنائية، بمعنى إنه هي اللي بتبني الـ
+
+155
+00:12:48,770 --> 00:12:53,070
+… الـ هيكل الخارجي للـ virus، والبعض الآخر بيكون
+
+156
+00:12:53,070 --> 00:12:56,950
+enzymes، في المحاضرة الأولى يا بنات أذكركم لما صنفنا 
+
+157
+00:12:56,950 --> 00:13:00,630
+أو ميزنا بين الخلية وبين الفيروس، كنا الخلية بتحتوي
+
+158
+00:13:00,630 --> 00:13:04,990
+على أنزيمات بكثرة، لكن في الفيروسات بعض الفيروسات
+
+159
+00:13:04,990 --> 00:13:08,930
+بيحتوي على أنزيمات، وأنا ذكرتلكوا لماذا بعض
+
+160
+00:13:08,930 --> 00:13:15,390
+الفيروسات تحتاج أنزيمات، أؤكد مرة أخرى أنه لو أنا
+
+161
+00:13:15,390 --> 00:13:20,510
+جيت على الغرفة هذه، ولجيت كل احتياجاتي لأداء مهمتي
+
+162
+00:13:21,210 --> 00:13:26,370
+تمام؟ متوفرة، يبقى أنا باجي بدون ما أحمل ولا حاجة،
+
+163
+00:13:26,370 --> 00:13:32,230
+لكن لو لازم أجيب معي flash وأحطه بالجهاز عشان
+
+164
+00:13:32,230 --> 00:13:35,330
+أقدر أعطي المحاضرة، تمام؟ أنا مضطر أحمل الـ flash
+
+165
+00:13:35,330 --> 00:13:39,930
+معي، صح؟ يبقى إذا ما وجدت بغيتي في الخلية لازم
+
+166
+00:13:39,930 --> 00:13:45,470
+أجيب بعض الأدوات اللي بتساعدني على إكمال المهمة، إذا
+
+167
+00:13:45,470 --> 00:13:48,150
+ممكن تكون Structural أو ممكن تكون إيه؟ إنزيم زي
+
+168
+00:13:48,150 --> 00:13:53,030
+الـ Polymerases، DNA أو RNA Polymerase، فيه Protein
+
+169
+00:13:53,030 --> 00:13:57,730
+مهم جدًا اسمه Matrix Protein، لما احنا قلنا إن بعض 
+
+170
+00:13:57,730 --> 00:14:02,350
+الفيروسات هي عبارة عن نوكليوكابسيد محاطة بـ
+
+171
+00:14:02,350 --> 00:14:07,560
+Envelope، يعني هل ترى الـ Envelope هذا في الهواء معلق
+
+172
+00:14:07,560 --> 00:14:12,520
+على الكبسيد، ولا لازم يكون فيه مادة بنائية بين
+
+173
+00:14:12,520 --> 00:14:16,580
+الكبسيد وبين الـ envelope؟ أوريكوا صورة هنا
+
+174
+00:14:16,580 --> 00:14:24,320
+شايفينها؟ هي الكبسيد، وهي الـ envelope، الآن الفراغ
+
+175
+00:14:24,320 --> 00:14:28,940
+هذا الموجود بيكون مملوء ببروتين، هذا البروتين عبارة
+
+176
+00:14:28,940 --> 00:14:34,780
+عن اللي هو الـ matrix البروتين، وهو بروتين مهم أيضًا
+
+177
+00:14:34,780 --> 00:14:44,180
+لبقاء الـ membrane ملتصق فيه، اللي هو الفيروس، شيء
+
+178
+00:14:44,180 --> 00:14:49,750
+غريب وعجيب في الفيروسات، أن احنا كنا بنتكلم عن Super
+
+179
+00:14:49,750 --> 00:14:52,810
+antigen في الـ cephalococcus aureus toxic shock
+
+180
+00:14:52,810 --> 00:14:55,850
+syndrome، تكسين فاكرينه؟ والصورة اللي أمامنا هنا
+
+181
+00:14:55,850 --> 00:15:02,270
+أيضًا بتوضح لنا الفكرة العامة، وإذا كركوا فيها الـ T
+
+182
+00:15:02,270 --> 00:15:06,710
+cell، ما بتشتغل لحالها، لازم الـ antigen presenting
+
+183
+00:15:06,710 --> 00:15:10,270
+cell تقولها أو تعطيها أمر، تقولها خذي الـ antigen
+
+184
+00:15:10,270 --> 00:15:15,480
+هذا اللي أنت specific له، وقومي اشتغلي، فالـ Antigen
+
+185
+00:15:15,480 --> 00:15:18,720
+Presenting Cell بيصير يدور على الـ T-Cells، الـ T
+
+186
+00:15:18,720 --> 00:15:23,680
+-Cells هم الأصغر الحركين الناشطين، تمام؟ الأنثى
+
+187
+00:15:23,680 --> 00:15:27,340
+الأولى ارتبطت بالثانية، وطلع مش specific، بتسيبها، و
+
+188
+00:15:27,340 --> 00:15:29,660
+بتروح على الثانية حتى تتعرّف على، لما تلاقي مين
+
+189
+00:15:29,660 --> 00:15:34,540
+الخلية المناسبة لها، الـ Super antigen، لما يلاقي T
+
+190
+00:15:34,540 --> 00:15:38,680
+-Cell جاية من Antigen Presenting Cell، بيروح
+
+191
+00:15:38,680 --> 00:15:42,840
+بربطهم ببعض، بلزقهم ببعض، بتصير الأنشطة، لأن الآن 
+
+192
+00:15:43,950 --> 00:15:48,830
+activation للـ T-cells، مش T-cell واحدة، T-cells،
+
+193
+00:15:48,830 --> 00:15:52,930
+وهذا الـ activation بيعمل immune response مبالغ
+
+194
+00:15:52,930 --> 00:15:56,430
+فيه، وهنا بيقول لك، toxic shock syndrome قد تقتل
+
+195
+00:15:56,430 --> 00:16:00,790
+الإنسان، لأنه رد فعل مناعي مبالغ فيه، طب العلماء
+
+196
+00:16:00,790 --> 00:16:04,630
+بيسألوا، بيقولوا، طب ليش هذا الفيروس محتاج يعمل هذا
+
+197
+00:16:04,630 --> 00:16:09,760
+العمل؟ وجدوا أن الفيروسات اللي بتمتلك Super antigen
+
+198
+00:16:09,760 --> 00:16:18,020
+بتحتاج إلى الخلايا اللي الها Antigen اسمه CD4، CD4 
+
+199
+00:16:18,020 --> 00:16:23,280
+cells، بتحتاجها للتكاثر، وبالتالي هي بتنشط جهاز
+
+200
+00:16:23,280 --> 00:16:28,700
+المناعة حتى تخرج هذه الخلايا وتقوم بالسيطرة عليها
+
+201
+00:16:28,700 --> 00:16:32,880
+إذن برضه في ذكاء من اللي هو الفيروسات، وأعتقد أن
+
+202
+00:16:32,880 --> 00:16:35,910
+الصورة هذه أو المحاضرة هذه بتوضح أن في بعض
+
+203
+00:16:35,910 --> 00:16:40,010
+الفيروسات الها Super Antigen زي الـ Epstein-Barr
+
+204
+00:16:40,010 --> 00:16:44,110
+Virus، EBV يا بنات باختصروه، مشهور كثير، هيمر معانا
+
+205
+00:16:44,110 --> 00:16:49,950
+كثير، EBV و CMV اللي هو الـ cytomegalovirus أيضًا من
+
+206
+00:16:49,950 --> 00:16:55,310
+الفيروسات المشهورة، و Retrovirus Mouse Memory Tumor
+
+207
+00:16:55,310 --> 00:17:01,120
+Virus، واضح من اسمه إنه للفئران مش إلينا، زي ما 
+
+208
+00:17:01,120 --> 00:17:04,740
+حكيناكوا النظرية بتقول إنه هي تحتاج إلى الـ CD4
+
+209
+00:17:04,740 --> 00:17:10,160
+cells، بوزتف سيلز، عشان تعمل replication، داخلة في
+
+210
+00:17:10,160 --> 00:17:16,640
+كمان Protein آخر في السلسلة اللي بقينا اسمه
+
+211
+00:17:16,640 --> 00:17:21,230
+تيجيومنت Protein، تيجيومنت Protein، فاكرين وين مولود الـ
+
+212
+00:17:21,230 --> 00:17:25,670
+matrix؟ وين مولود الـ matrix؟ بين الـ … بين الـ …
+
+213
+00:17:25,670 --> 00:17:29,430
+الـ … الـ envelope وبين الـ capsid، هذا أيضًا مولود في
+
+214
+00:17:29,430 --> 00:17:32,430
+تلك المنطقة، يعني في اثنين عندنا Protein قد يكون
+
+215
+00:17:32,430 --> 00:17:35,790
+مولودة في هذه المنطقة، الـ matrix Protein، زائد تجي من
+
+216
+00:17:35,790 --> 00:17:40,250
+الـ protein، لكن له وظيفة أساسية، regulatory، كلمة 
+
+217
+00:17:40,250 --> 00:17:44,320
+regulatory يعني عملية تنظيم، وكلمة تنظيم في الـ … هي
+
+218
+00:17:44,320 --> 00:17:48,020
+تنظيم للجينات، switch on و switch off، بيسموها 
+
+219
+00:17:48,020 --> 00:17:51,500
+transcription and translational factors، بتعمل
+
+220
+00:17:51,500 --> 00:17:55,900
+عملية control للـ viral والـ cellular process، يعني
+
+221
+00:17:55,900 --> 00:18:01,000
+بتسيطر على كل من العمليات الخلوية اللي هي في
+
+222
+00:18:01,000 --> 00:18:04,820
+الخلية بتتم، وعلى العمليات اللي بتتم فيها أيضًا الـ
+
+223
+00:18:04,820 --> 00:18:06,100
+virus itself
+
+224
+00:18:09,280 --> 00:18:13,060
+التركيب التالي في محاضرتنا اللي هو الـ Envelope،
+
+225
+00:18:13,060 --> 00:18:14,900
+الـ Viral Envelope، وأنا على حقيقة تحدثت عنه
+
+226
+00:18:14,900 --> 00:18:18,880
+المرة الماضية باستفاضة، لكن كونه كان ضمن يعني 
+
+227
+00:18:18,880 --> 00:18:22,980
+مقدمة، الآن واجب علينا أنه نذكر نُلقي المعلومات عن
+
+228
+00:18:22,980 --> 00:18:30,360
+هذا التركيب، إيه، بتعرفوا مصطلح budding؟ تبرعم، أي
+
+229
+00:18:30,360 --> 00:18:34,890
+أخر كلمة في اللوحة اسمها تبرعم، budding، هنا الآن 
+
+230
+00:18:34,890 --> 00:18:37,930
+نتخيل الغرفة هذه اللي احنا قاعدين فيها هي عبارة عن
+
+231
+00:18:37,930 --> 00:18:42,910
+خلية، الجدران تبعتها هتكون cell membrane، الآن
+
+232
+00:18:42,910 --> 00:18:46,850
+الفيروس هو طالع من الخلية، وما فيش باب للخلية ولا
+
+233
+00:18:46,850 --> 00:18:51,850
+فيه شباك يطلع منه، فجدامه حال من اثنين، يا اما يدمر
+
+234
+00:18:51,850 --> 00:18:57,650
+ويمزق الـ membrane ويطلع، أو في حال ثانية أكثر لطفًا
+
+235
+00:18:57,650 --> 00:19:03,770
+تمام، وفي فائدة للفيروس أن هو طالع، بيضغط على الـ
+
+236
+00:19:03,770 --> 00:19:07,990
+cell membrane، تمام؟ وبيقطع قطعة منه، بيغلق فيها
+
+237
+00:19:07,990 --> 00:19:12,730
+نفسه، وهذا هو الـ envelope، الآن برضه هو ذكي، بياخدش
+
+238
+00:19:12,730 --> 00:19:18,350
+قطعة مش إله، وهذه أصلاً مش إله، طب هذه كيف يخليها
+
+239
+00:19:18,350 --> 00:19:23,050
+إله؟ هو جوا بتكاثر، بيروح بيصنع بروتينات بيسموها
+
+240
+00:19:23,050 --> 00:19:27,950
+glycoproteins أو glycoproteins، تمام؟ وبيغرسها في 
+
+241
+00:19:27,950 --> 00:19:32,760
+الـ membranes اللي موجودة بتاعة الخلية، فهو طالع
+
+242
+00:19:32,760 --> 00:19:36,360
+بيضغط على الـ membrane، وبياخد يزور من الـ membrane
+
+243
+00:19:36,360 --> 00:19:39,280
+إيش في الـ membrane، الآن الـ glycoproteins، الـ
+
+244
+00:19:39,280 --> 00:19:44,160
+glycoproteins بتخلي الـ membrane إله، يعني viral
+
+245
+00:19:44,160 --> 00:19:47,900
+membrane، بس هو في واقع الأمر مأخوذ من مين؟ من الـ
+
+246
+00:19:47,900 --> 00:19:51,920
+cell membrane، كل الفيروسات اللي الها
+
+247
+00:20:00,690 --> 00:20:05,370
+المصدر الانفلوب الأساسي هو إما cell membrane أو
+
+248
+00:20:05,370 --> 00:20:09,500
+nuclear membrane، لكن يضاف له بعض البروتينات، اللي 
+
+249
+00:20:09,500 --> 00:20:14,920
+سميناها جليكو بروتينز، وهي يعني تبدو في الـ … تحت
+
+250
+00:20:14,920 --> 00:20:20,960
+الـ electron microscope، كـ بنسميها spikes، نتوئات أو 
+
+251
+00:20:20,960 --> 00:20:25,820
+أشواك تمام نتوءات أو أشواك طيب عرفنا من وين ..
+
+252
+00:20:25,820 --> 00:20:30,680
+عرفنا من وين بيجي الـ membrane اللي هو الـ viral 
+
+253
+00:20:30,680 --> 00:20:36,280
+envelope ما هي الفوائد التي يجنيها الفيروس من 
+
+254
+00:20:36,280 --> 00:20:41,840
+اكتساب envelope؟ المرة الماضية تكلمنا عن مساوء،
+
+255
+00:20:41,840 --> 00:20:47,120
+مظبوط؟ المقال اللي بتكلم عن فوائد الفائدة الأولى 
+
+256
+00:20:47,120 --> 00:20:54,620
+أنه بيتجنب جهاز المناعة، ليش؟ لأن هذا الـ envelope
+
+257
+00:20:54,620 --> 00:20:59,520
+هو envelope أصلا من نفس الشخص فبالتالي جهاز 
+
+258
+00:20:59,520 --> 00:21:03,320
+المناعة مش هيتعرف عليه على أنه غريب، هاي واحد،
+
+259
+00:21:03,320 --> 00:21:09,980
+اثنين: عملية إصابة خلية أخرى بتصير أسهل ما يكون،
+
+260
+00:21:09,980 --> 00:21:15,460
+ليش؟ لأن مبرين يلزق في مبرين، يلتصق في مبرين، مش 
+
+261
+00:21:15,460 --> 00:21:18,900
+هيحتاج Receptor، مبرين بيلتصق في مبرين، بيفتح 
+
+262
+00:21:18,900 --> 00:21:22,100
+وبيدخل الفيروس جوا للداخل، وحنبقى لما نوريكوا 
+
+263
+00:21:22,100 --> 00:21:25,740
+عملية الـ replication للـ viruses، نوريكوا كيف بتتم 
+
+264
+00:21:25,740 --> 00:21:30,540
+هذه العملية إن شاء الله من خلال animation، إذن هي 
+
+265
+00:21:30,540 --> 00:21:33,660
+فائدة ثانية، الفائدة الأولى: هروب من جهاز المناعة
+
+266
+00:21:33,660 --> 00:21:40,000
+رقم اثنين: سهولة في إنه يعمل دخول لخلايا أخرى بينما 
+
+267
+00:21:40,000 --> 00:21:45,420
+العيوب: it confers instability to the virus يعني 
+
+268
+00:21:45,420 --> 00:21:51,400
+الفيروس في البيئة بيكون غير ثابت وأي دمار للـ
+
+269
+00:21:51,400 --> 00:21:56,940
+membrane تمام؟ هذا دمار للفيروس itself لأنه سيفقد 
+
+270
+00:21:56,940 --> 00:21:59,900
+قدرته على الإرتباط، ما لوش قدرة على الإرتباط إلا من
+
+271
+00:21:59,900 --> 00:22:05,100
+خلال هذا الـ membrane أنا بجيب مثالين بقول أنه عندي 
+
+272
+00:22:05,100 --> 00:22:08,990
+فيروس الـ influenza وفيروس الرشح طبعا أنت ما بتعرفش 
+
+273
+00:22:08,990 --> 00:22:13,250
+الفرق بينهم رشح و Influenza بالنسبة لكوا إيه؟ واحد 
+
+274
+00:22:13,250 --> 00:22:16,430
+يعني الواحد بدي يقول أنا مرشح ممكن يقول أنا مفلوز 
+
+275
+00:22:16,430 --> 00:22:20,390
+أو العكس ما بتفرقش معاه لكن واقع الأمر هم مرضين 
+
+276
+00:22:20,390 --> 00:22:25,790
+مختلفين ومسبباتهم مختلفة تماما Influenza virus و
+
+277
+00:22:25,790 --> 00:22:30,170
+Rhino virus الـ Rhino virus هو فيروس مسبب للرشح الـ
+
+278
+00:22:30,170 --> 00:22:36,480
+Influenza virus enveloped بينما الـ common cold
+
+279
+00:22:36,480 --> 00:22:43,180
+virus، non-enveloped، naked، مين حيضل مقعد أطول 
+
+280
+00:22:43,180 --> 00:22:47,260
+في البيئة؟ الـ non-enveloped اللي هو مين؟ اللي هو
+
+281
+00:22:47,260 --> 00:22:50,720
+الـ rhino virus، فيروس الرشح، وعلى فكرة، أنتوا 
+
+282
+00:22:50,720 --> 00:22:56,480
+بترشحوا بعض الأحيان دون ما تجدوا مبرر لإنكوا 
+
+283
+00:22:56,480 --> 00:22:57,080
+رشحتوا
+
+284
+00:22:59,880 --> 00:23:04,580
+ما قابلتوا مع واحد مريض بالمرة مرشح من .. من أشهر 
+
+285
+00:23:04,580 --> 00:23:08,240
+وبعد ذلك رشحتوا لإن كنتوا مساكتوا surface طاولة 
+
+286
+00:23:08,240 --> 00:23:12,340
+على سبيل المثال كان قاعد عليها حدا أو بالقرب منها
+
+287
+00:23:12,340 --> 00:23:18,080
+حدا عطس يومين ثلاثة أربعة خمسة وإحنا مساكنا الأسطح 
+
+288
+00:23:18,080 --> 00:23:21,680
+ووضعنا أصابعنا إما في العين عن طريق الحكة العين 
+
+289
+00:23:21,680 --> 00:23:27,430
+أو في مكان آخر تمام؟ فبشكل عام اللي أنا بدي أوصله من
+
+290
+00:23:27,430 --> 00:23:32,230
+الرسالة هذه أنه فيروس الرشح اللي لا يمتلك الـ
+
+291
+00:23:32,230 --> 00:23:37,330
+envelope أكثر قدرة على البقاء في البيئة من الفيروس 
+
+292
+00:23:37,330 --> 00:23:42,760
+تبع الـ influenza اللي هو enveloped virus وأكبر دليل 
+
+293
+00:23:42,760 --> 00:23:45,840
+قلنا لكم على أن كل الفيروسات اللي بتاعة من الـ gas والـ
+
+294
+00:23:45,840 --> 00:23:48,820
+intestinal tract infection كلها non enveloped
+
+295
+00:23:48,820 --> 00:23:51,960
+لو enveloped كان محد ما اتناولناها مع الطعام أو 
+
+296
+00:23:51,960 --> 00:23:56,940
+الشرب الملوث كان دم رثوين في اللي هو المعدة طلعوا 
+
+297
+00:23:56,940 --> 00:24:03,360
+على آخر سطر في اللوحة Hepatitis A virus، Polio virus 
+
+298
+00:24:03,360 --> 00:24:06,800
+طبعا Hepatitis A أحد فيروسات الـ Hepatitis اللي 
+
+299
+00:24:06,800 --> 00:24:10,460
+بينتقل عن طريق الطعام والشراب Hepatitis A virus مش 
+
+300
+00:24:10,460 --> 00:24:13,740
+كلهم بينتقلوا عن طريق الجنس والدم تمام؟ فيه 
+
+301
+00:24:13,740 --> 00:24:16,180
+بينتقل عن طريق اللي هو عشان ذلك أنا قلتلكوا المرة 
+
+302
+00:24:16,180 --> 00:24:20,820
+الماضية المجموعة كلها لا تشترك في صفة إلا إنهم 
+
+303
+00:24:20,820 --> 00:24:26,680
+قادرين على إصابة مين؟ اللي هو الكبد، الـ Poliovirus
+
+304
+00:24:26,680 --> 00:24:28,880
+اللي هو مرض شيء للأطفال وفيه مجموعة من الـ
+
+305
+00:24:28,880 --> 00:24:32,740
+Coxsackievirus، Echinovirus، Norwalk Virus و
+
+306
+00:24:32,740 --> 00:24:35,880
+Rotavirus كلها بتعمل Gastrointestinal tract
+
+307
+00:24:35,880 --> 00:24:41,320
+infection وكلها naked viruses أو non-enveloped
+
+308
+00:24:41,320 --> 00:24:46,840
+virus طيب كيف بينتقلوا الـ .. الـ .. الـ .. الـ
+
+309
+00:24:46,840 --> 00:24:50,200
+enveloped viruses؟ كيف بينتقلوا؟ طلعوا على برضه 
+
+310
+00:24:50,200 --> 00:24:53,520
+اللوحة وركزوا كويس على اللون الأحمر إذا كان إن بين 
+
+311
+00:24:53,520 --> 00:24:55,220
+إشي من اللون من اللون الأحمر
+
+312
+00:24:58,600 --> 00:25:03,320
+فين دي direct transmission؟ وكلمة direct يعني تاني 
+
+313
+00:25:03,320 --> 00:25:06,620
+أنه بشكل مباشر زي مثلا عن طريق الـ blood 
+
+314
+00:25:06,620 --> 00:25:10,580
+transfusion أنه نقل الدم عن طريق الـ sexual
+
+315
+00:25:10,580 --> 00:25:15,520
+transmission وهذا برضه close contact مثل مثال عليها
+
+316
+00:25:15,520 --> 00:25:18,340
+الـ Human Immunodeficiency Virus اللي هو فيروس الـ
+
+317
+00:25:18,340 --> 00:25:21,880
+AIDS الـ Herpes Simplex Virus Type 2 النوع الثاني 
+
+318
+00:25:21,880 --> 00:25:27,400
+من الـ Herpes و Hepatitis B and C لحظة لو على 
+
+319
+00:25:27,400 --> 00:25:31,680
+السابقة كنا نتكلم عن Hepatitis A بنتقل عن طريق الـ 
+
+320
+00:25:31,680 --> 00:25:36,960
+Fecal Oral اللي هو يعني البراز اللي لوث الطعام أو 
+
+321
+00:25:36,960 --> 00:25:39,980
+الشرب بينما أنا بتكلم على Sexual Transmission و
+
+322
+00:25:39,980 --> 00:25:44,940
+Blood Transmission الـ Insect Bites عضّات الحشرات 
+
+323
+00:25:44,940 --> 00:25:50,240
+مثل الـ yellow fever والوضْع الفيروس أو عن طريق 
+
+324
+00:25:50,240 --> 00:25:54,480
+الـ animal bites مثل ده الكلب اللي هو السعار أو الـ
+
+325
+00:25:54,480 --> 00:25:58,120
+rabies الكلب اللي بيحمل المسعور اللي بيحمل الإنسان 
+
+326
+00:25:58,120 --> 00:26:02,020
+بينقله فيروس الـ rabies وفيروس الـ rabies enveloped 
+
+327
+00:26:02,020 --> 00:26:07,970
+virus أيضا مجموعة كبيرة من الفيروسات اللي هي 
+
+328
+00:26:07,970 --> 00:26:12,210
+enveloped تنتقل مباشرة عبر الـ respiratory droplets
+
+329
+00:26:12,210 --> 00:26:17,230
+اللي هو عبر الجهاز التنفسي مثل الإنفلوانزا فيروس 
+
+330
+00:26:17,230 --> 00:26:22,050
+الميسلز فيروس الميسلز اللي هي الحصبة تمام؟ والروبيلا 
+
+331
+00:26:22,050 --> 00:26:25,350
+اللي هي الحصبة الألمانية والرسبيراتوري سينسيتيا 
+
+332
+00:26:25,350 --> 00:26:27,350
+الفيروس هتعرف عليها ده لاحقا إن شاء الله 
+
+333
+00:26:27,350 --> 00:26:31,310
+والفارسيلازوستر فيروس برضه هذا فيروس من الفيروسات 
+
+334
+00:26:31,310 --> 00:26:34,610
+اللي أنتوا قسّبتوا فيها وإنتوا صغار اللي هو جدري 
+
+335
+00:26:34,610 --> 00:26:38,330
+الماء بيسموه جدري الماء بيسموه chickenpox باللغة 
+
+336
+00:26:38,330 --> 00:26:44,500
+الإنكليزية هذه اللوحة بتثبت لنا بالفعل أن الـ 
+
+337
+00:26:44,500 --> 00:26:48,420
+Enveloped viruses غير قادرة على البقاء لفترات 
+
+338
+00:26:48,420 --> 00:26:54,480
+طويلة وبالتالي لابد من وسيلة معينة لنقلها من شخص 
+
+339
+00:26:54,480 --> 00:26:58,560
+مصاب إلى آخر إما عبر الحشرات، عبر الحيوانات، 
+
+340
+00:26:58,560 --> 00:27:02,540
+direct contact اللي هي من الدم أو sexual contact
+
+341
+00:27:02,540 --> 00:27:04,280
+أو عبر الـ respiratory tract
+
+342
+00:27:07,440 --> 00:27:10,860
+واللي لو حالي أمامنا بتوضح أنه الـ .. الـ .. الـ ..
+
+343
+00:27:10,860 --> 00:27:13,120
+الكلام اللي ذكرته على فيروس الرشح اللي هو الـ 
+
+344
+00:27:13,120 --> 00:27:17,760
+Rhino virus و Rhino معناها أنف Rhino معناها أنف
+
+345
+00:27:17,760 --> 00:27:21,560
+اللي هو الفيروس اللي بيعمل رشح في الأنف يعني تمام؟ 
+
+346
+00:27:21,560 --> 00:27:24,700
+which are transmitted by respiratory droplets are 
+
+347
+00:27:24,700 --> 00:27:29,980
+naked nucleocapsid viruses ليس لديها أي envelope
+
+348
+00:27:29,980 --> 00:27:33,820
+وبالفعل تستطيع البقاء لفترات طويلة جدا
+
+349
+00:27:36,500 --> 00:27:41,360
+ما زلنا في الـ viral envelope وبنتكلم عن type 
+
+350
+00:27:41,360 --> 00:27:48,360
+specificity أو حاجة بنسميها serotypes المحاضرة 
+
+351
+00:27:48,360 --> 00:27:54,400
+الأولى ذكرتلكوا أنا حاجة بتخص الـ HIV الـ aids أن 
+
+352
+00:27:54,400 --> 00:28:00,500
+هذا الفيروس دراسات اللي أوجدت عليه طورت علم المناعة 
+
+353
+00:28:00,500 --> 00:28:06,280
+صح؟ وطورت علم الفيروسات ومع ذلك لحد الآن ليس لدينا 
+
+354
+00:28:06,280 --> 00:28:13,120
+vaccine فعال ضد هذا الفيروس عدم مقدرتنا على إنتاج 
+
+355
+00:28:13,120 --> 00:28:17,260
+vaccine أو لقاح قد يكون لها أسباب متنوعة لكن أحد 
+
+356
+00:28:17,260 --> 00:28:23,580
+أشهر أو أهم الأسباب أن يكون هناك سلالات مختلفة 
+
+357
+00:28:23,580 --> 00:28:29,740
+ومتنوعة Serotypes زي البكتيريا اللي درسناها كان 
+
+358
+00:28:29,740 --> 00:28:32,360
+برضه في كتير فيها Serotypes زي السلمونيلا مثلا 
+
+359
+00:28:32,360 --> 00:28:38,780
+والشغلة بعض الفيروسات تحتوي على several Serotypes
+
+360
+00:28:38,780 --> 00:28:45,790
+تسمعوا بالـ influenza vaccine كل سنة بينزل vaccine
+
+361
+00:28:45,790 --> 00:28:51,470
+مختلف عن السنة اللي جابلها ليش؟ لأن الشركات 
+
+362
+00:28:51,470 --> 00:28:55,930
+المصنعة على الـ vaccine بتحاول تجمع السلالات التي 
+
+363
+00:28:55,930 --> 00:29:00,130
+كانت سارية في العالم في العالم الماضي وبتعمل ضدها 
+
+364
+00:29:00,130 --> 00:29:06,090
+أو بتعطينا .. بتعطينا مضعفة أو ميتة وبتلقح الناس 
+
+365
+00:29:06,090 --> 00:29:13,000
+فيها ليش؟ عشان تحميهم من possible possible لكن كثير 
+
+366
+00:29:13,000 --> 00:29:14,760
+من الناس اللي أخذوا الـ vaccine صار عندهم 
+
+367
+00:29:14,760 --> 00:29:18,860
+influenza، دلالة على إيه؟ على إن السلالات اللي .. 
+
+368
+00:29:18,860 --> 00:29:22,960
+اللي .. اللي صار لها protection عندهم قدرت سلالة 
+
+369
+00:29:22,960 --> 00:29:27,180
+جديدة ما فيه protection، وبالتالي أصيبوا بالـ
+
+370
+00:29:27,180 --> 00:29:32,200
+influenza المفهوم هنا بالـ Serotypes هو التنوّع 
+
+371
+00:29:32,200 --> 00:29:38,780
+للأنتيجينات اللي هو الفيروسات أحد مسببات التنوّع هو 
+
+372
+00:29:38,780 --> 00:29:43,340
+الـ Glycoproteins اللي قلنا لكم بتغرسها الفيروسات 
+
+373
+00:29:43,340 --> 00:29:47,280
+في الـ cell membrane اللي على الـ envelope إذن الـ
+
+374
+00:29:47,280 --> 00:29:50,920
+envelope قد يكون مسؤول عن مين؟ عن Serotype
+
+375
+00:29:50,920 --> 00:29:56,680
+variation أو التنوّع في الـ Serotypes مثال الـ 
+
+376
+00:29:56,680 --> 00:30:00,880
+Poliovirus type 1 and 2 and 3 are distinguished by
+
+377
+00:30:00,880 --> 00:30:07,880
+the antigenicity of their capsid proteins، it is
+
+378
+00:30:07,880 --> 00:30:10,660
+important to know the number of serotypes of a
+
+379
+00:30:10,660 --> 00:30:14,920
+virus because the vaccine should contain the prevalent
+
+380
+00:30:14,920 --> 00:30:15,940
+serotype
+
+381
+00:30:19,700 --> 00:30:24,120
+الشائعة الـ prevalent serotype معناها يتبع علينا
+
+382
+00:30:24,120 --> 00:30:29,800
+معرفة الشائع ال common اللي يسبب المرض للإنسان حتى
+
+383
+00:30:29,800 --> 00:30:33,220
+نقدر نحطه في مين؟ في ال vaccine هتعطي مثال ماعرفش
+
+384
+00:30:33,220 --> 00:30:38,340
+من البكتيريا فيه بكتيريا اسمها Streptococcus
+
+385
+00:30:38,340 --> 00:30:43,700
+pneumonia فيها 84 serotype يا بنات 84 serotype هل
+
+386
+00:30:43,700 --> 00:30:48,900
+يُعقل أن نعمل vaccine نحط فيه 84 أنتجين عشان مرض
+
+387
+00:30:48,900 --> 00:30:55,570
+واحد؟ هذا يُنهِك جهاز المناعة فبنروح بندور على أكثر
+
+388
+00:30:55,570 --> 00:31:00,330
+السلالات شيوعا في المنطقة عشرة، سبعة، ثمانية
+
+389
+00:31:00,330 --> 00:31:04,190
+وبنجمعهم مع بعض وبنعطي vaccine بدل ما نعطيه ضد
+
+390
+00:31:04,190 --> 00:31:07,810
+الـ 84 serotype. إذا كلمة prevalent معناها
+
+391
+00:31:07,810 --> 00:31:12,950
+الشائع،  أولا الأمراض بشكل كبير؟ لماذا نحتاج
+
+392
+00:31:12,950 --> 00:31:18,170
+السلالات أن نحطها مع بعض؟ بقول إنه ما فيش حاجة
+
+393
+00:31:18,170 --> 00:31:24,160
+اسمها cross protection. عشان cross protection يعني
+
+394
+00:31:24,160 --> 00:31:31,160
+لو أنا اتطعمت، اتحصنت ضد سلالة X مش هتحميني من
+
+395
+00:31:31,160 --> 00:31:36,880
+سلالة Y. فلازم أُطعم ضد سلالة X وضد Y. ما فيش شيء
+
+396
+00:31:36,880 --> 00:31:41,380
+بينهم cross protection وهذا نقطة كتير مهمة في
+
+397
+00:31:41,380 --> 00:31:48,130
+الفيروسات. Viruses that have multiple serotypes, have
+
+398
+00:31:48,130 --> 00:31:52,950
+antigenic variants, have an enhanced ability to
+
+399
+00:31:52,950 --> 00:31:56,930
+evade our host defenses because antibody against
+
+400
+00:31:56,930 --> 00:32:00,250
+one serotype will not protect against another
+
+401
+00:32:00,250 --> 00:32:05,730
+serotype. هذا المعنى إن ما فيش cross protection. إن
+
+402
+00:32:05,730 --> 00:32:11,150
+الحماية ضد سلالة لن تحميك ضد سلالات الأخرى، هذه
+
+403
+00:32:11,150 --> 00:32:20,820
+نقطة كتير مهمة. نجي الآن لبعض المكونات الشائعة في
+
+404
+00:32:20,820 --> 00:32:25,160
+الـ Virology، لكن أقل شيوعا من الـ virus itself،
+
+405
+00:32:25,160 --> 00:32:28,480
+يسموها atypical virus-like agents، إيش معنى
+
+406
+00:32:28,480 --> 00:32:35,000
+atypical؟ يعني لا تشبه الفيروس غير نمطية، غير نمطية
+
+407
+00:32:35,000 --> 00:32:41,800
+Defective viruses, pseudovirion, viroids و prions
+
+408
+00:32:41,800 --> 00:32:48,220
+طبعا الـ defective viruses كلمة defective معناها
+
+409
+00:32:48,220 --> 00:32:56,480
+خربان، غير فعال، تمام؟ ما المقصود بـ defective
+
+410
+00:32:56,480 --> 00:33:00,220
+virus؟ لما نتعلم الـ replication هنشوف أن
+
+411
+00:33:00,220 --> 00:33:05,770
+الفيروسات بتكون الكابسيت تبعتها وبتكون المادة
+
+412
+00:33:05,770 --> 00:33:09,910
+الوراثية تبعتها وفي الآخر بتعمل عملية packaging
+
+413
+00:33:09,910 --> 00:33:14,390
+إيش يعني packaging؟ بتحط المادة الوراثية اللي
+
+414
+00:33:14,390 --> 00:33:18,950
+تبعتها جوا الكابسيت تبعتها وبتحطها على جانب زي في
+
+415
+00:33:18,950 --> 00:33:24,790
+المصانع، بنغلف، تغليف، packaging. الآن عشان تعمل
+
+416
+00:33:24,790 --> 00:33:28,130
+مادة وراثية، إيش بتساوي هي؟ الفيروسات، بتقطع
+
+417
+00:33:28,130 --> 00:33:32,960
+المادة الوراثية للخلية اللي هي موجودة فيها. قد ينتج
+
+418
+00:33:32,960 --> 00:33:38,240
+عن التقطيع يا بنات قطع من الـ DNA تبع الخلية مش عال
+
+419
+00:33:38,240 --> 00:33:44,420
+فيروس مشابهة في الشكل والطول والحجم لمين؟ للفيروس
+
+420
+00:33:44,420 --> 00:33:54,550
+فبدل ما يعبي جوا الكبسيد مادة وراثية من الخلية
+
+421
+00:33:54,550 --> 00:34:00,810
+بيعمل 
+
+422
+00:34:00,810 --> 00:34:05,310
+infection لخلية تانية بيدخل المادة الوراثية تبعتها
+
+423
+00:34:08,420 --> 00:34:11,760
+مادة وراثية تبعت بكتيريا تبعتها ات خلية عادية
+
+424
+00:34:11,760 --> 00:34:15,480
+وبالتالي لن يكون هناك أي تكاثر لهذا الفيروس
+
+425
+00:34:15,480 --> 00:34:21,840
+فبنسميه defective virus. طبعا البعض هيظن أن العملية
+
+426
+00:34:21,840 --> 00:34:27,120
+هذه عملية نادرة الحدوث. طبعا قد يصل في بعض
+
+427
+00:34:27,120 --> 00:34:30,940
+الفيروسات الـ replication في الـ replication
+
+428
+00:34:30,940 --> 00:34:35,880
+للفيروسات أن لكل مائة فيروس خربان يطلع فيروس واحد
+
+429
+00:34:35,880 --> 00:34:37,140
+حقيقي
+
+430
+00:34:38,950 --> 00:34:44,350
+متخيلين كيف الوضع؟ أن كمية الفيروسات الفاسدة،
+
+431
+00:34:44,350 --> 00:34:49,410
+الغير سليمة، عالية بالمقارنة مع مين؟ مع الفيروسات
+
+432
+00:34:49,410 --> 00:34:54,330
+السليمة وهذا بيفسروا أو بيستخدموه العلماء في تفسير
+
+433
+00:34:54,330 --> 00:34:59,430
+مهم جدا، إيش تفسير هذا؟ لماذا يشفى الإنسان من
+
+434
+00:34:59,430 --> 00:35:04,650
+الأمراض الفيروسية دون ما الحاجة إلى علاج؟ أكمرة
+
+435
+00:35:04,650 --> 00:35:09,850
+رشحنا، أكمرة فلوزنا، واشوفينا بدون أي علاج؟ قلنا
+
+436
+00:35:09,850 --> 00:35:13,750
+أنه ممكن تكون الـ defective virus هي السبب في أننا
+
+437
+00:35:13,750 --> 00:35:19,530
+نشوفينا من هذه الفيروسات، كيف؟ نفترض أن الفيروس دخل
+
+438
+00:35:19,530 --> 00:35:25,510
+خلية، تكاثر، طلع عشرين كويسين وعشرين مش كويسين،
+
+439
+00:35:25,510 --> 00:35:29,370
+لأن كلمة واحد، مية لواحد، هذا أعلى نسبة بنعرفها
+
+440
+00:35:29,370 --> 00:35:32,190
+أحنا، أعلى نسبة بنعرفها، لكن ممكن يكون واحد لمية،
+
+441
+00:35:32,190 --> 00:35:36,930
+العكس، طلع خمسين وخمسين، الآن الخمسين الكويسين
+
+442
+00:35:36,930 --> 00:35:41,340
+هيعملوا infection لمين؟ لخمسين خلية أخرى. الخمسين
+
+443
+00:35:41,340 --> 00:35:47,480
+الخربانين هيدخلوا خمسين خلية أخرى لكن مش هيعملوا
+
+444
+00:35:47,480 --> 00:35:52,160
+infection بس عارفين في نفسكم إيش عملهم؟ منعوا أي
+
+445
+00:35:52,160 --> 00:35:57,360
+فيروس يدخل الخلية اللي دخلوها هم يبقى صار فيه
+
+446
+00:35:57,360 --> 00:36:01,720
+تنافس ما بين الفيروس السليم وما بين الفيروس اللي
+
+447
+00:36:01,720 --> 00:36:07,020
+هو الفاسد وبالتالي قللنا من احتمالية إصابة الخلايا
+
+448
+00:36:07,020 --> 00:36:12,150
+الأخرى. وكل ما زادت عملية الـ infection كل ما زاد عدد
+
+449
+00:36:12,150 --> 00:36:16,890
+من الفيروسات الخربانة وبالتالي زاد التنافس فبيقل
+
+450
+00:36:16,890 --> 00:36:22,730
+عدد الفيروسات اللي هي الفعالة وهذا مدعا للشفاء دون
+
+451
+00:36:22,730 --> 00:36:27,570
+ما الحاجة إلى علاج. وصلت الصورة؟ إذا الـ defective
+
+452
+00:36:27,570 --> 00:36:31,310
+viruses قد تكون سبب في هذا الموضوع. الـ defective
+
+453
+00:36:31,310 --> 00:36:35,990
+virus هذا عبارة عن فيروس فيه خلل صار فيه mutation
+
+454
+00:36:35,990 --> 00:36:42,040
+صار فيه mutation. الميوتاشن خلته غير قادر على أنه
+
+455
+00:36:42,040 --> 00:36:46,860
+يعمل replication داخل الخلايا بذاته. لازم يكون
+
+456
+00:36:46,860 --> 00:36:51,560
+معاها helper virus. إيش يعني helper virus؟ مساعد
+
+457
+00:36:51,560 --> 00:36:56,560
+وأفضل نموذج مثال عليه عندنا فيروسين واحد اسمه
+
+458
+00:36:56,560 --> 00:37:03,420
+hepatitis B وواحد اسمه hepatitis D. إذا وجدنا دي عند
+
+459
+00:37:03,420 --> 00:37:08,220
+إنسان فلازم يكون عنده بي لأن دي .. اتذكروا دي
+
+460
+00:37:08,220 --> 00:37:13,380
+defective. دي defective خربان ولن يستطيع أن يقوم
+
+461
+00:37:13,380 --> 00:37:18,680
+بعمل عدوى للإنسان إلا إذا كان بي موجود. بي هو اللي
+
+462
+00:37:18,680 --> 00:37:24,580
+بيساعده على حدوث التكاثر تمام؟ إذا هذا هو الـ
+
+463
+00:37:24,580 --> 00:37:30,840
+defective virus. الـ pseudovirion هو الفيروس اللي من
+
+464
+00:37:30,840 --> 00:37:36,900
+بره وفي جوا مادة وراثية من الخلية المصابة والذي
+
+465
+00:37:36,900 --> 00:37:42,800
+ذكرت بأنه يمكن أن يكون جزء من متفسير لماذا يشفى
+
+466
+00:37:42,800 --> 00:37:48,740
+الناس بدون الحاجة إلى علاج لأن يصبح هذا الـ
+
+467
+00:37:48,740 --> 00:37:54,260
+pseudovirion منافس للفيروس الحقيقي من حيث عدم سماح
+
+468
+00:37:54,260 --> 00:38:01,100
+له بإصابة خلايا أخرى. الـ Viroids حاجة غريبة في
+
+469
+00:38:01,100 --> 00:38:05,580
+الحقيقة هي عبارة عن single molecule of circular
+
+470
+00:38:05,580 --> 00:38:10,480
+RNA without a protein coat or envelope. يعني مادة
+
+471
+00:38:10,480 --> 00:38:15,580
+وراثية بس مالهاش كبسيد ولا إلها envelope وقادرة
+
+472
+00:38:15,580 --> 00:38:19,740
+على إنها تعمل infection للنباتات، غالبا الـ
+
+473
+00:38:19,740 --> 00:38:25,170
+Viroids بتصيبش الإنسان بتصيب اللي هو النباتة. والجزء
+
+474
+00:38:25,170 --> 00:38:29,750
+الأخير من الـ atypical virus-like particles اللي
+
+475
+00:38:29,750 --> 00:38:34,310
+هي الـ prions والـ prions الحقيقة صدمة ونقلة
+
+476
+00:38:34,310 --> 00:38:39,190
+نوعية كبيرة في العلوم الحياتية لأنها أثبتت لنا أن
+
+477
+00:38:39,190 --> 00:38:44,150
+هناك بعض البروتينات التي لا تمتلك أي صفة من صفات
+
+478
+00:38:44,150 --> 00:38:49,930
+الحياة أو الخلوية تمام. استطاعت أن تحدث مرض للإنسان
+
+479
+00:38:49,930 --> 00:38:56,050
+من خلال فقط تغيير conformation شكل بدل ما هي هيك
+
+480
+00:38:56,050 --> 00:39:02,070
+صارت هيك تمام. لما يتغير الشكل تتغير الوظيفة وهذا
+
+481
+00:39:02,070 --> 00:39:07,330
+الـ abnormal protein بيتكاثر بتحويل الـ normal إلى
+
+482
+00:39:07,330 --> 00:39:16,110
+abnormal. ومن مزايا هذا البروتين أنه مقاوم لعمليات
+
+483
+00:39:16,110 --> 00:39:20,310
+الـ disinfection والـ sterilization اللي بنتكلم عنها
+
+484
+00:39:20,310 --> 00:39:23,720
+بشكل مستمر. بتاع اللي بيلاقيها resistance to
+
+485
+00:39:23,720 --> 00:39:28,100
+formaldehyde and nucleases، they are inactivated،
+
+486
+00:39:28,100 --> 00:39:32,260
+يعني ممكن نقتلهم أو ندمرهم، هم أصلا مش أحياء عشان
+
+487
+00:39:32,260 --> 00:39:35,640
+نقتلهم، لكن بندمرهم من خلال الـ chlor،
+
+488
+00:39:35,640 --> 00:39:39,320
+الـ hypochlorite أو الـ Sodium hydroxide وعن طريق الـ
+
+489
+00:39:39,320 --> 00:39:46,200
+auto-claving. بنفهم أنه صار على قائمة المقاومة
+
+490
+00:39:46,200 --> 00:39:49,920
+للحرارة. المقاومة للحرارة. صار عندنا الـ Prions
+
+491
+00:39:49,920 --> 00:39:52,920
+وبعدين هنتكلم عن الـ Endospore Forming تمام؟ اللي
+
+492
+00:39:52,920 --> 00:39:55,880
+هنتكلم عن الـ Endospore Forming هنتكلم عن ليه الـ
+
+493
+00:39:55,880 --> 00:39:59,000
+Prions؟ والـ Prions طبعا هي المسئولة عن إحداث
+
+494
+00:39:59,000 --> 00:40:02,720
+الأمراض الخطيرة اللي مثل الـ Transmissible
+
+495
+00:40:02,720 --> 00:40:06,960
+Spongiform Encephalopathy أو اللي احنا بنسميه جنون
+
+496
+00:40:06,960 --> 00:40:12,410
+البقر Mad Cow Disease وفيه مقابله مرض بشري اللي هو
+
+497
+00:40:12,410 --> 00:40:17,710
+اسمه Creutzfeld Jakob Disease وفي الأغنام أيضا
+
+498
+00:40:17,710 --> 00:40:23,930
+فيها اسم Scrapy في الأغنام برضه خرف بسبب جنون
+
+499
+00:40:23,930 --> 00:40:28,670
+للأغنام. طبعا في نظريات عن نشوء هذا الـ Prions أن
+
+500
+00:40:28,670 --> 00:40:32,650
+شاء الله لما ندخل بتعمق أكبر في هذا الموضوع لأن 
+
+501
+00:40:32,650 --> 00:40:38,010
+هذا له فصل خاص فيه في الـ Prions إن شاء الله هنتطلع
+
+502
+00:40:38,010 --> 00:40:43,280
+عليه طبعا هذه اللوحة غالبا كل ما .. ما هو موجود
+
+503
+00:40:43,280 --> 00:40:47,280
+فيها احنا ذكرناه عن الفروقات بين الـ بريونات وال
+
+504
+00:40:47,280 --> 00:40:51,520
+conventional viruses الـ .. الـ بريونات مافيهاش
+
+505
+00:40:51,520 --> 00:40:57,720
+نوكليك أسيد normally encoded by our genes، يعني
+
+506
+00:40:57,720 --> 00:41:01,760
+جيناتنا، بينما الفيروسات لها their own genes الـ ال
+
+507
+00:41:01,760 --> 00:41:04,460
+.. الـ .. الـ .. الـ inactivation الفيروسات سهل
+
+508
+00:41:04,460 --> 00:41:07,820
+نعملها inactivation بينما الـ prions صعب نعملها
+
+509
+00:41:07,820 --> 00:41:12,260
+inactivation تحت الميكروسكوب الإلكتروني بنشوف الـ
+
+510
+00:41:12,260 --> 00:41:16,220
+prions عبارة عن filaments بينما الفيروسات إلها شكل
+
+511
+00:41:16,220 --> 00:41:20,120
+محدد إما a causal hydral أو قلنا عنه الـ helical أو
+
+512
+00:41:20,120 --> 00:41:24,300
+الـ complex morphology infection induces antibody
+
+513
+00:41:24,300 --> 00:41:29,200
+بالـ prions لأن هو أصلا جزء من الخلية احنا الـ prions
+
+514
+00:41:29,200 --> 00:41:32,940
+جزء من خلية فبتالي كيف خلية بتعمله أجسام مضادة
+
+515
+00:41:32,940 --> 00:41:36,860
+فلن تقوم بيعمل أجسام مضادة بينما الفيروسات غالبا
+
+516
+00:41:36,860 --> 00:41:41,640
+بيصيرلها أجسام مضادة مافيش inflammation أيضا في الـ
+
+517
+00:41:41,640 --> 00:41:44,040
+prions بينما في inflammation في الـ conventional
+
+518
+00:41:44,040 --> 00:41:44,920
+virus
+
+519
+00:41:48,110 --> 00:41:52,810
+الـ Prions اللوحة هذه هي توضيح لماذا ذكرته عن
+
+520
+00:41:52,810 --> 00:41:56,950
+طبيعتها أن هي protein، cellular proteins و بتتراوح
+
+521
+00:41:56,950 --> 00:42:01,010
+ما بين سبعة و عشرين ألف لتلاتين ألف كيلو دالتون
+
+522
+00:42:01,010 --> 00:42:07,550
+غالبا single cellular genes لها حاجة غريبة أن
+
+523
+00:42:07,550 --> 00:42:12,800
+الناس المصابين والغير مصابين ما لاجيناش فروق في
+
+524
+00:42:12,800 --> 00:42:18,680
+تركيز لا الجين ولا الـ protein ولا الـ RNA تبع اللي
+
+525
+00:42:18,680 --> 00:42:23,200
+هو الـ ال .. وهذا مؤشر على انه فقط الـ confirmation
+
+526
+00:42:23,200 --> 00:42:27,520
+اللي هو الشكل الخاص بالـ brain هل هو normal ولا
+
+527
+00:42:27,520 --> 00:42:30,900
+abnormal هو المسئول وبهك إن شاء الله بنكون انتهينا
+
+528
+00:42:30,900 --> 00:42:34,560
+من الجزء الأول من محاضرتنا ليها الـ structure of
+
+529
+00:42:34,560 --> 00:42:37,820
+viruses وإن شاء الله نكمل المرة القادمة وهيكون
+
+530
+00:42:37,820 --> 00:42:41,070
+موضوعنا عن الـ replication of virus 
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/7XJrhnztack_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/7XJrhnztack_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..65e9f66a177d30f8c54b6c1ab3996c4296bca103
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/7XJrhnztack_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 4046, "start": 21.06, "end": 40.46, "text": "بسم الله الرحمن الرحيم نكمل إن شاء الله موضوع الـ structure of viruses وبدأنا بالحديث المحاضرة السابقة عن ال viral nucleic acid وقلنا إنها بتتميز الفيروسات بإنه هي الوحيدة التي يعني يمكن القول بإنه هي تمتلك genome مكون من RNA", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 8717, 24793, 1211, 36145, 13412, 16606, 21984, 3714, 2407, 11242, 45367, 2423, 39184, 3877, 295, 21785, 4032, 44510, 10721, 8315, 20666, 5016, 16254, 12984, 9673, 5016, 46958, 25720, 21136, 16758, 28671, 18871, 2423, 16132, 14962, 299, 8258, 4032, 4587, 1211, 8315, 36145, 11296, 39894, 39237, 1829, 11622, 27188, 13546, 41779, 9307, 4724, 28814, 1863, 3224, 39896, 2423, 2407, 5016, 25708, 3660, 38392, 37495, 22653, 7251, 43020, 25062, 12610, 4724, 28814, 1863, 3224, 39896, 46811, 2655, 23275, 21953, 3714, 30544, 9154, 22484], "avg_logprob": -0.14757898646396594, "compression_ratio": 1.6355555555555557, 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{"start": 140.0, "end": 140.82, "word": " الوراثية", "probability": 0.973828125}, {"start": 140.82, "end": 141.48, "word": " و", "probability": 0.322509765625}, {"start": 141.48, "end": 141.64, "word": " ال", "probability": 0.53857421875}, {"start": 141.64, "end": 142.22, "word": " capsid", "probability": 0.85693359375}, {"start": 142.22, "end": 142.84, "word": " عبارة", "probability": 0.9912109375}, {"start": 142.84, "end": 143.04, "word": " عن", "probability": 0.9931640625}, {"start": 143.04, "end": 143.5, "word": " protein", "probability": 0.84130859375}, {"start": 143.5, "end": 144.4, "word": " coat", "probability": 0.55126953125}, {"start": 144.4, "end": 146.22, "word": " مكون", "probability": 0.848388671875}, {"start": 146.22, "end": 146.64, "word": " من", "probability": 0.9921875}, {"start": 146.64, "end": 147.5, "word": " capsomers", "probability": 0.8470052083333334}, {"start": 147.5, "end": 147.86, "word": " و", "probability": 0.65771484375}, {"start": 147.86, "end": 147.98, 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{"start": 225.25, "end": 227.21, "word": " النوكليو", "probability": 0.84375}, {"start": 227.21, "end": 227.55, "word": " كبسيد", "probability": 0.994140625}, {"start": 227.55, "end": 227.79, "word": " قد", "probability": 0.982177734375}, {"start": 227.79, "end": 228.13, "word": " تكون", "probability": 0.987548828125}, {"start": 228.13, "end": 228.55, "word": " فيروس", "probability": 0.765625}, {"start": 228.55, "end": 228.87, "word": " كامل", "probability": 0.978515625}], "temperature": 1.0}, {"id": 10, "seek": 25375, "start": 230.95, "end": 253.75, "text": "الـ Arrangement وطبيعة الـ Capsomers هي اللي بتحدد الـ Geometric Symmetry للفيروسات ايش يعني الـ Geometric Symmetry؟ يعني مثلا في عندي في اللوحة زي ما انتوا شايفين في الصورة أعلى اللوحة عندي كورية مكونة من مثلثات هذه المثلثات عبارة عن عشرين مثلث", "tokens": [6027, 39184, 1587, 14521, 518, 4032, 9566, 21292, 27884, 2423, 39184, 383, 2382, 298, 433, 39896, 13672, 1829, 39894, 24401, 3215, 2423, 39184, 2876, 29470, 3902, 2174, 9889, 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861.1, "text": "في الهوى معلج على الكبسيد ولا لازم يكون فيه مادة بنائية بين الكبسيد وبين ال envelope أوريكوا صورة هنا شايفينها؟ هي الكبسيد وهي ال envelope", "tokens": [41185, 2423, 3224, 2407, 7578, 20449, 1211, 7435, 15844, 33251, 3555, 3794, 25708, 49429, 5296, 31377, 2304, 7251, 30544, 8978, 3224, 3714, 18513, 3660, 44945, 16373, 10632, 49374, 33251, 3555, 3794, 25708, 46599, 9957, 2423, 19989, 5551, 13063, 1829, 4117, 14407, 20328, 13063, 3660, 34105, 13412, 995, 33911, 9957, 11296, 22807, 39896, 33251, 3555, 3794, 25708, 37037, 1829, 2423, 19989], "avg_logprob": -0.19544056693061454, "compression_ratio": 1.6857142857142857, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 846.38, "end": 846.58, "word": "في", "probability": 0.265625}, {"start": 846.58, "end": 846.9, "word": " الهوى", "probability": 0.7899169921875}, {"start": 846.9, "end": 847.56, "word": " معلج", "probability": 0.8688151041666666}, {"start": 847.56, "end": 848.68, "word": " على", "probability": 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{"start": 854.48, "end": 854.96, "word": " أوريكوا", "probability": 0.74970703125}, {"start": 854.96, "end": 856.18, "word": " صورة", "probability": 0.9899088541666666}, {"start": 856.18, "end": 856.58, "word": " هنا", "probability": 0.8798828125}, {"start": 856.58, "end": 859.18, "word": " شايفينها؟", "probability": 0.7811686197916666}, {"start": 859.18, "end": 859.54, "word": " هي", "probability": 0.39208984375}, {"start": 859.54, "end": 860.12, "word": " الكبسيد", "probability": 0.97509765625}, {"start": 860.12, "end": 860.64, "word": " وهي", "probability": 0.92822265625}, {"start": 860.64, "end": 860.74, "word": " ال", "probability": 0.96875}, {"start": 860.74, "end": 861.1, "word": " envelope", "probability": 0.8759765625}], "temperature": 1.0}, {"id": 36, "seek": 88760, "start": 862.38, "end": 887.6, "text": "الان الفراغ هذا الموجود بيكون مملوق ببروتين هذا البروتين عبارة عن اللي هو ال matrix البروتين وهو بروتين مهم أيضا لبقاء ال membrane ملتصق فيه اللي هو الفيروس شيء غريب وعجيب 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"text": "إن في بعض الفيروسات إلها Super Antigen زي الـ Epstein-Barr Virus EBV يا بنات باختصروه مشهور كتير هيمر معانا كتير EBV و CMV اللي هو الـ cytomegalovirus أيضا من الفيروسات المشهورة و Retrovirus Mouse Memory Tumor Virus واضح من اسمه إنه للفئران مش إلنا", "tokens": [28814, 1863, 8978, 45030, 11242, 27188, 13546, 41779, 9307, 11933, 1211, 11296, 4548, 5130, 3213, 30767, 1829, 2423, 39184, 9970, 9089, 12, 33, 2284, 39790, 50148, 53, 35186, 4724, 8315, 2655, 4724, 47283, 2655, 9381, 32887, 3224, 37893, 3224, 13063, 9122, 2655, 13546, 39896, 29973, 20449, 7649, 995, 9122, 2655, 13546, 50148, 53, 4032, 20424, 53, 13672, 1829, 31439, 2423, 39184, 40248, 423, 9800, 5179, 9619, 36632, 11242, 995, 9154, 27188, 13546, 41779, 9307, 9673, 8592, 3224, 13063, 3660, 4032, 11495, 24088, 9619, 29383, 38203, 314, 449, 284, 39790, 4032, 46958, 5016, 9154, 24525, 2304, 3224, 36145, 3224, 24976, 5172, 19986, 2288, 7649, 37893, 11933, 1211, 8315], "avg_logprob": -0.2342303261436798, "compression_ratio": 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الـ CD4 cells بوستف سيلز عشان تعمل replication داخلة في كمان protein أخر في السلسلة اللي بقعنا اسمه تيجيومنت بروتين تيجيومنت بروتين", "tokens": [2407, 11622, 1829, 19446, 11331, 4117, 1829, 8315, 4117, 14407, 28239, 19913, 2288, 10632, 39894, 39648, 36145, 3224, 39896, 6055, 33753, 26108, 30731, 2423, 39184, 6743, 19, 5438, 4724, 2407, 14851, 5172, 8608, 26895, 11622, 6225, 8592, 7649, 6055, 25957, 1211, 39911, 11778, 47283, 37977, 8978, 9122, 2304, 7649, 7944, 5551, 34740, 8978, 21136, 1211, 3794, 37977, 13672, 1829, 4724, 4587, 3615, 8315, 24525, 2304, 3224, 6055, 1829, 7435, 1829, 20498, 29399, 4724, 32887, 2655, 9957, 6055, 1829, 7435, 1829, 20498, 29399, 4724, 32887, 2655, 9957], "avg_logprob": -0.21839080562536745, "compression_ratio": 1.5384615384615385, "no_speech_prob": 0.0, "words": [{"start": 1020.78, "end": 1021.06, "word": "وزي", "probability": 0.7897135416666666}, {"start": 1021.06, "end": 1021.12, "word": " ما", "probability": 0.98095703125}, {"start": 1021.12, "end": 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طالع بيدغط على الـ membrane وبياخد يزوء من الـ membrane ايش في الـ membrane الآن الـ glycoproteins الـ glycoproteins بتخلي ال membrane إله يعني viral membrane بس هو في واقع الأمر مأخوذ من مين؟ من ال cell membrane كل الفيروسات اللي إلها", "tokens": [5172, 3224, 2407, 23032, 6027, 3615, 4724, 25708, 17082, 9566, 15844, 2423, 39184, 19651, 4032, 21292, 47283, 3215, 7251, 11622, 2407, 38207, 9154, 2423, 39184, 19651, 1975, 1829, 8592, 8978, 2423, 39184, 19651, 6024, 48506, 2423, 39184, 22633, 13084, 81, 1370, 1292, 2423, 39184, 22633, 13084, 81, 1370, 1292, 39894, 9778, 20292, 2423, 19651, 11933, 43761, 37495, 22653, 16132, 19651, 4724, 3794, 31439, 8978, 36764, 4587, 3615, 16247, 29973, 3714, 10721, 9778, 2407, 8848, 9154, 3714, 9957, 22807, 9154, 2423, 2815, 19651, 28242, 27188, 13546, 41779, 9307, 13672, 1829, 11933, 1211, 11296], "avg_logprob": -0.2562163837494389, "compression_ratio": 1.7828282828282829, "no_speech_prob": 0.0, "words": [{"start": 1171.66, "end": 1172.14, "word": 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0.9549153645833334}, {"start": 1866.63, "end": 1867.05, "word": " prevalent", "probability": 0.50048828125}, {"start": 1867.05, "end": 1867.81, "word": " معناها", "probability": 0.762451171875}, {"start": 1867.81, "end": 1868.51, "word": " الشائع", "probability": 0.96875}, {"start": 1868.51, "end": 1868.89, "word": " ولا", "probability": 0.44482421875}, {"start": 1868.89, "end": 1869.01, "word": " دي", "probability": 0.825439453125}, {"start": 1869.01, "end": 1869.21, "word": " واحدة", "probability": 0.84130859375}, {"start": 1869.21, "end": 1869.65, "word": " الأمراض", "probability": 0.86962890625}, {"start": 1869.65, "end": 1870.09, "word": " بشكل", "probability": 0.9908854166666666}, {"start": 1870.09, "end": 1870.57, "word": " كبير", "probability": 0.96630859375}, {"start": 1870.57, "end": 1872.07, "word": " لماذا", "probability": 0.94775390625}, {"start": 1872.07, "end": 1872.95, "word": " نحتاج", "probability": 0.99462890625}, {"start": 1872.95, "end": 1875.17, "word": " السلالات", "probability": 0.9864501953125}, {"start": 1875.17, "end": 1875.31, "word": " أن", "probability": 0.38916015625}, {"start": 1875.31, "end": 1876.29, "word": " نحطها", "probability": 0.9285888671875}, {"start": 1876.29, "end": 1876.59, "word": " مع", "probability": 0.98974609375}, {"start": 1876.59, "end": 1877.53, "word": " بعض؟", "probability": 0.9197591145833334}, {"start": 1877.53, "end": 1877.63, "word": " بقول", "probability": 0.46044921875}, {"start": 1877.63, "end": 1877.85, "word": " إنه", "probability": 0.598876953125}, {"start": 1877.85, "end": 1878.03, "word": " مافيش", "probability": 0.8837890625}, {"start": 1878.03, "end": 1878.17, "word": " حاجة", "probability": 0.9033203125}, {"start": 1878.17, "end": 1878.35, "word": " اسمها", "probability": 0.8155924479166666}, {"start": 1878.35, "end": 1878.57, "word": " cross", "probability": 0.8369140625}, {"start": 1878.57, "end": 1879.11, "word": " protection", "probability": 0.708984375}], "temperature": 1.0}, {"id": 78, "seek": 190200, "start": 1880.5, "end": 1902.0, "text": "عشان cross protection يعني لو انا اتطعمت اتحصنت ضد سلالة X مش هتحميني من سلالة Y فلازم اتطعم ضد سلالة X و ضد Y مافيش شي بينهم cross protection و هذا نقطة كتير مهمة في الفيروس", "tokens": [3615, 8592, 7649, 3278, 6334, 37495, 22653, 45164, 1975, 8315, 1975, 2655, 9566, 25957, 2655, 1975, 2655, 5016, 9381, 29399, 48812, 3215, 8608, 1211, 6027, 3660, 1783, 37893, 8032, 2655, 35571, 9957, 1829, 9154, 8608, 1211, 6027, 3660, 398, 6156, 1211, 31377, 2304, 1975, 2655, 9566, 25957, 48812, 3215, 8608, 1211, 6027, 3660, 1783, 4032, 48812, 3215, 398, 19446, 41185, 8592, 44049, 49374, 16095, 3278, 6334, 4032, 23758, 8717, 47432, 3660, 9122, 2655, 13546, 3714, 16095, 3660, 8978, 27188, 13546, 41779], "avg_logprob": -0.19035822680083717, "compression_ratio": 1.6607142857142858, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1880.5, "end": 1880.8, "word": "عشان", "probability": 0.5834554036458334}, {"start": 1880.8, "end": 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"word": " من", "probability": 0.98779296875}, {"start": 1891.16, "end": 1891.74, "word": " سلالة", "probability": 0.993408203125}, {"start": 1891.74, "end": 1892.36, "word": " Y", "probability": 0.98095703125}, {"start": 1892.36, "end": 1893.0, "word": " فلازم", "probability": 0.9549560546875}, {"start": 1893.0, "end": 1893.5, "word": " اتطعم", "probability": 0.8280029296875}, {"start": 1893.5, "end": 1893.84, "word": " ضد", "probability": 0.99462890625}, {"start": 1893.84, "end": 1894.32, "word": " سلالة", "probability": 0.9954833984375}, {"start": 1894.32, "end": 1894.7, "word": " X", "probability": 0.98876953125}, {"start": 1894.7, "end": 1894.88, "word": " و", "probability": 0.9658203125}, {"start": 1894.88, "end": 1895.06, "word": " ضد", "probability": 0.58319091796875}, {"start": 1895.06, "end": 1895.48, "word": " Y", "probability": 0.5537109375}, {"start": 1895.48, "end": 1896.8, "word": " مافيش", "probability": 0.9119466145833334}, {"start": 1896.8, "end": 1896.88, "word": " شي", "probability": 0.386962890625}, {"start": 1896.88, "end": 1897.3, "word": " بينهم", "probability": 0.9541015625}, {"start": 1897.3, "end": 1898.44, "word": " cross", "probability": 0.88623046875}, {"start": 1898.44, "end": 1899.34, "word": " protection", "probability": 0.85888671875}, {"start": 1899.34, "end": 1899.68, "word": " و", "probability": 0.54150390625}, {"start": 1899.68, "end": 1899.78, "word": " هذا", "probability": 0.197021484375}, {"start": 1899.78, "end": 1900.04, "word": " نقطة", "probability": 0.9905598958333334}, {"start": 1900.04, "end": 1900.46, "word": " كتير", "probability": 0.97509765625}, {"start": 1900.46, "end": 1901.14, "word": " مهمة", "probability": 0.9777018229166666}, {"start": 1901.14, "end": 1901.38, "word": " في", "probability": 0.91748046875}, {"start": 1901.38, "end": 1902.0, "word": " الفيروس", "probability": 0.9611002604166666}], "temperature": 1.0}, {"id": 79, "seek": 193221, "start": 1904.09, "end": 1932.21, "text": "Viruses that have multiple serotypes, have antigenic variants, have an enhanced ability to evade our host defenses because antibody against one serotype will not protect against another serotype هذا المعنى إن مافيش cross protection إن الحماية ضد سلالة لن تحميك ضد سلالات الأخرى، هذه نقطة كتير مهمة", "tokens": [53, 347, 8355, 300, 362, 3866, 816, 19477, 11, 362, 2511, 3213, 299, 21669, 11, 362, 364, 21191, 3485, 281, 1073, 762, 527, 3975, 35989, 570, 34507, 1970, 472, 816, 13108, 486, 406, 2371, 1970, 1071, 816, 13108, 23758, 9673, 3615, 1863, 7578, 36145, 19446, 41185, 8592, 3278, 6334, 36145, 21542, 15042, 10632, 48812, 3215, 8608, 1211, 6027, 3660, 5296, 1863, 6055, 35571, 1829, 4117, 48812, 3215, 8608, 1211, 6027, 9307, 16247, 34740, 7578, 12399, 29538, 8717, 47432, 3660, 9122, 2655, 13546, 3714, 16095, 3660], "avg_logprob": -0.1581577055676039, "compression_ratio": 1.512396694214876, "no_speech_prob": 0.0, "words": [{"start": 1904.09, "end": 1904.71, "word": "Viruses", "probability": 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to", "probability": 0.982421875}, {"start": 1912.95, "end": 1913.61, "word": " evade", "probability": 0.979248046875}, {"start": 1913.61, "end": 1914.01, "word": " our", "probability": 0.87646484375}, {"start": 1914.01, "end": 1914.37, "word": " host", "probability": 0.9462890625}, {"start": 1914.37, "end": 1915.01, "word": " defenses", "probability": 0.8251953125}, {"start": 1915.01, "end": 1915.67, "word": " because", "probability": 0.68359375}, {"start": 1915.67, "end": 1916.27, "word": " antibody", "probability": 0.434326171875}, {"start": 1916.27, "end": 1916.93, "word": " against", "probability": 0.9521484375}, {"start": 1916.93, "end": 1917.25, "word": " one", "probability": 0.93359375}, {"start": 1917.25, "end": 1917.81, "word": " serotype", "probability": 0.978515625}, {"start": 1917.81, "end": 1918.29, "word": " will", "probability": 0.88818359375}, {"start": 1918.29, "end": 1918.59, "word": " not", "probability": 0.94580078125}, {"start": 1918.59, "end": 1919.07, "word": " protect", "probability": 0.9462890625}, {"start": 1919.07, "end": 1919.83, "word": " against", "probability": 0.9423828125}, {"start": 1919.83, "end": 1920.25, "word": " another", "probability": 0.89453125}, {"start": 1920.25, "end": 1921.17, "word": " serotype", "probability": 0.97998046875}, {"start": 1921.17, "end": 1921.55, "word": " هذا", "probability": 0.215576171875}, {"start": 1921.55, "end": 1922.05, "word": " المعنى", "probability": 0.9774169921875}, {"start": 1922.05, "end": 1922.47, "word": " إن", "probability": 0.367919921875}, {"start": 1922.47, "end": 1922.75, "word": " مافيش", "probability": 0.8470052083333334}, {"start": 1922.75, "end": 1923.11, "word": " cross", "probability": 0.85888671875}, {"start": 1923.11, "end": 1924.33, "word": " protection", "probability": 0.6845703125}, {"start": 1924.33, "end": 1925.73, "word": " إن", "probability": 0.5908203125}, {"start": 1925.73, "end": 1926.91, "word": " الحماية", "probability": 0.9635416666666666}, {"start": 1926.91, 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0.98388671875}], "temperature": 1.0}, {"id": 91, "seek": 224566, "start": 2221.9, "end": 2245.66, "text": "إذا وجدنا دي عند إنسان فلازم يكون عنده بي لأن دي .. اتذكروا دي defective دي defective قربان و لن يستطيع أن يقوم بعمل عدوى للإنسان إلا إذا كان بي موجود بي هو اللي بيساعده على حدوث التكاثر تمام؟ إذا هذا هو ال defective virus", "tokens": [28814, 15730, 49610, 3215, 8315, 11778, 1829, 43242, 36145, 3794, 7649, 6156, 1211, 31377, 2304, 7251, 30544, 43242, 3224, 4724, 1829, 5296, 33456, 11778, 1829, 4386, 1975, 2655, 8848, 37983, 14407, 11778, 1829, 16445, 488, 11778, 1829, 16445, 488, 12174, 25513, 7649, 4032, 5296, 1863, 7251, 14851, 9566, 40228, 14739, 7251, 4587, 20498, 4724, 25957, 1211, 6225, 3215, 2407, 7578, 24976, 28814, 1863, 3794, 7649, 11933, 15040, 11933, 15730, 25961, 4724, 1829, 3714, 29245, 23328, 4724, 1829, 31439, 13672, 1829, 4724, 1829, 3794, 995, 22488, 3224, 15844, 11331, 3215, 2407, 12984, 16712, 4117, 5718, 104, 2288, 46811, 10943, 22807, 11933, 15730, 23758, 31439, 2423, 16445, 488, 5752], "avg_logprob": -0.1552372636894385, "compression_ratio": 1.7596153846153846, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2221.9, "end": 2222.28, "word": "إذا", "probability": 0.87744140625}, {"start": 2222.28, "end": 2222.94, "word": " وجدنا", "probability": 0.97900390625}, {"start": 2222.94, "end": 2223.14, "word": " دي", "probability": 0.509185791015625}, {"start": 2223.14, "end": 2223.42, "word": " عند", "probability": 0.861328125}, {"start": 2223.42, "end": 2224.14, "word": " إنسان", "probability": 0.96533203125}, {"start": 2224.14, "end": 2224.72, "word": " فلازم", "probability": 0.894775390625}, {"start": 2224.72, "end": 2224.9, "word": " يكون", "probability": 0.985595703125}, {"start": 2224.9, "end": 2225.48, "word": " عنده", "probability": 0.991943359375}, {"start": 2225.48, "end": 2226.26, "word": " بي", "probability": 0.75830078125}, {"start": 2226.26, "end": 2226.68, "word": " لأن", "probability": 0.69482421875}, {"start": 2226.68, "end": 2227.12, "word": " دي", "probability": 0.778076171875}, {"start": 2227.12, "end": 2227.18, "word": " ..", "probability": 0.1878662109375}, {"start": 2227.18, "end": 2228.06, "word": " اتذكروا", "probability": 0.89345703125}, {"start": 2228.06, "end": 2228.22, "word": " دي", "probability": 0.9453125}, {"start": 2228.22, "end": 2228.98, "word": " defective", "probability": 0.758544921875}, {"start": 2228.98, "end": 2229.74, "word": " دي", "probability": 0.60760498046875}, {"start": 2229.74, "end": 2230.42, "word": " defective", "probability": 0.94580078125}, {"start": 2230.42, "end": 2230.96, "word": " قربان", "probability": 0.717041015625}, {"start": 2230.96, "end": 2232.04, "word": " و", "probability": 0.552734375}, {"start": 2232.04, "end": 2232.2, "word": " لن", "probability": 0.703857421875}, {"start": 2232.2, "end": 2232.74, "word": " يستطيع", "probability": 0.93505859375}, {"start": 2232.74, "end": 2232.94, "word": " أن", "probability": 0.5751953125}, {"start": 2232.94, "end": 2233.38, "word": " يقوم", "probability": 0.99169921875}, {"start": 2233.38, "end": 2233.94, "word": " بعمل", "probability": 0.92529296875}, {"start": 2233.94, "end": 2234.48, "word": " عدوى", "probability": 0.970947265625}, {"start": 2234.48, "end": 2235.28, "word": " للإنسان", "probability": 0.971875}, {"start": 2235.28, "end": 2235.6, "word": " إلا", "probability": 0.966796875}, {"start": 2235.6, "end": 2235.9, "word": " إذا", "probability": 0.974609375}, {"start": 2235.9, "end": 2236.48, "word": " كان", "probability": 0.9921875}, {"start": 2236.48, "end": 2236.96, "word": " بي", "probability": 0.97314453125}, {"start": 2236.96, "end": 2237.56, "word": " موجود", "probability": 0.9866536458333334}, {"start": 2237.56, "end": 2238.1, "word": " بي", "probability": 0.91552734375}, {"start": 2238.1, "end": 2238.46, "word": " هو", "probability": 0.9775390625}, {"start": 2238.46, "end": 2238.68, "word": " اللي", "probability": 0.9716796875}, {"start": 2238.68, "end": 2239.62, "word": " بيساعده", "probability": 0.9896647135416666}, {"start": 2239.62, "end": 2240.08, "word": " على", "probability": 0.92138671875}, {"start": 2240.08, "end": 2241.56, "word": " حدوث", "probability": 0.994384765625}, {"start": 2241.56, "end": 2242.6, "word": " التكاثر", "probability": 0.97724609375}, {"start": 2242.6, "end": 2243.34, "word": " تمام؟", "probability": 0.80419921875}, {"start": 2243.34, "end": 2243.5, "word": " إذا", "probability": 0.722412109375}, {"start": 2243.5, "end": 2243.78, "word": " هذا", "probability": 0.85888671875}, {"start": 2243.78, "end": 2244.14, "word": " هو", "probability": 0.99365234375}, {"start": 2244.14, "end": 2244.58, "word": " ال", "probability": 0.9345703125}, {"start": 2244.58, "end": 2245.18, "word": " defective", "probability": 0.855224609375}, {"start": 2245.18, "end": 2245.66, "word": " virus", "probability": 0.94384765625}], "temperature": 1.0}, {"id": 92, "seek": 227666, "start": 2246.96, "end": 2276.66, "text": "الـ pseudovirion هو الفيروس اللي من برة و في جوا مادة وراثية من الخلية المصابة والذي ذكرت بأنه يمكن أن يكون جزء من متفسير لماذا يشفى الناس بدون الحاجة إلى علاج لأن يصبح هذا الـ pseudovirion منافس للفيروس الحقيقي من حيث عدم سماح له بإصابة خلايا أخرى", "tokens": [6027, 39184, 25505, 532, 5179, 347, 313, 31439, 27188, 13546, 41779, 13672, 1829, 9154, 4724, 25720, 4032, 8978, 10874, 14407, 3714, 18513, 3660, 4032, 2288, 5718, 104, 10632, 9154, 33962, 1211, 10632, 9673, 9381, 16758, 3660, 16070, 8848, 1829, 29910, 37983, 2655, 4724, 33456, 3224, 7251, 43020, 14739, 7251, 30544, 10874, 11622, 38207, 9154, 44650, 36178, 13546, 32767, 45636, 995, 7251, 8592, 5172, 7578, 2423, 8315, 3794, 47525, 11536, 21542, 26108, 3660, 30731, 11203, 26108, 5296, 33456, 7251, 9381, 49628, 23758, 2423, 39184, 25505, 532, 5179, 347, 313, 3714, 8315, 36178, 24976, 5172, 13546, 41779, 21542, 38436, 38436, 9154, 11331, 1829, 12984, 6225, 40448, 8608, 15042, 5016, 46740, 4724, 28814, 9381, 16758, 3660, 16490, 15040, 25528, 5551, 34740, 7578], "avg_logprob": -0.13242188096046448, "compression_ratio": 1.782426778242678, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2246.96, "end": 2247.24, "word": "الـ", "probability": 0.900390625}, {"start": 2247.24, "end": 2247.98, "word": " pseudovirion", "probability": 0.7882568359375}, {"start": 2247.98, "end": 2248.64, "word": " هو", "probability": 0.95703125}, {"start": 2248.64, "end": 2250.42, "word": " الفيروس", "probability": 0.8284505208333334}, {"start": 2250.42, "end": 2250.66, "word": " اللي", "probability": 0.783203125}, {"start": 2250.66, "end": 2250.84, "word": " من", "probability": 0.966796875}, {"start": 2250.84, "end": 2251.34, "word": " برة", "probability": 0.7314453125}, {"start": 2251.34, "end": 2251.82, "word": " و", "probability": 0.6875}, {"start": 2251.82, "end": 2252.42, "word": " في", "probability": 0.3818359375}, {"start": 2252.42, "end": 2252.78, "word": " جوا", "probability": 0.3692626953125}, {"start": 2252.78, "end": 2253.56, "word": " مادة", "probability": 0.8291015625}, {"start": 2253.56, "end": 2254.34, "word": " وراثية", "probability": 0.94716796875}, {"start": 2254.34, "end": 2254.82, "word": " من", "probability": 0.970703125}, {"start": 2254.82, "end": 2255.32, "word": " الخلية", "probability": 0.9677734375}, {"start": 2255.32, "end": 2256.26, "word": " المصابة", "probability": 0.9678955078125}, {"start": 2256.26, "end": 2256.9, "word": " والذي", "probability": 0.77880859375}, {"start": 2256.9, "end": 2257.38, "word": " ذكرت", "probability": 0.95703125}, {"start": 2257.38, "end": 2258.06, "word": " بأنه", "probability": 0.9140625}, {"start": 2258.06, "end": 2259.08, "word": " يمكن", "probability": 0.955810546875}, {"start": 2259.08, "end": 2259.28, "word": " أن", "probability": 0.7900390625}, {"start": 2259.28, "end": 2259.76, "word": " يكون", "probability": 0.987060546875}, {"start": 2259.76, "end": 2260.52, "word": " جزء", "probability": 0.99365234375}, {"start": 2260.52, "end": 2260.86, "word": " من", "probability": 0.9853515625}, {"start": 2260.86, "end": 2261.94, "word": " متفسير", "probability": 0.8863932291666666}, {"start": 2261.94, "end": 2262.4, "word": " لماذا", "probability": 0.9733072916666666}, {"start": 2262.4, "end": 2262.8, "word": " يشفى", "probability": 0.8814697265625}, {"start": 2262.8, "end": 2263.22, "word": " الناس", "probability": 0.9913736979166666}, {"start": 2263.22, "end": 2266.02, "word": " بدون", "probability": 0.97509765625}, {"start": 2266.02, "end": 2266.4, "word": " الحاجة", "probability": 0.9814453125}, {"start": 2266.4, "end": 2266.56, "word": " إلى", "probability": 0.8408203125}, {"start": 2266.56, "end": 2266.92, "word": " علاج", "probability": 0.98095703125}, {"start": 2266.92, "end": 2267.2, "word": " لأن", "probability": 0.877197265625}, {"start": 2267.2, "end": 2268.16, "word": " يصبح", "probability": 0.8898111979166666}, {"start": 2268.16, "end": 2268.52, "word": " هذا", "probability": 0.97119140625}, {"start": 2268.52, "end": 2268.74, "word": " الـ", "probability": 0.858642578125}, {"start": 2268.74, "end": 2269.38, "word": " pseudovirion", "probability": 0.9611328125}, {"start": 2269.38, "end": 2270.1, "word": " منافس", "probability": 0.9461263020833334}, {"start": 2270.1, "end": 2270.7, "word": " للفيروس", "probability": 0.9541015625}, {"start": 2270.7, "end": 2271.38, "word": " الحقيقي", "probability": 0.9845377604166666}, {"start": 2271.38, "end": 2271.9, "word": " من", "probability": 0.8134765625}, {"start": 2271.9, "end": 2272.22, "word": " حيث", "probability": 0.9869791666666666}, {"start": 2272.22, "end": 2273.14, "word": " عدم", "probability": 0.9775390625}, {"start": 2273.14, "end": 2274.26, "word": " سماح", "probability": 0.75634765625}, {"start": 2274.26, "end": 2274.62, "word": " له", "probability": 0.76416015625}, {"start": 2274.62, "end": 2275.52, "word": " بإصابة", "probability": 0.94189453125}, {"start": 2275.52, "end": 2276.0, "word": " خلايا", "probability": 0.8274739583333334}, {"start": 2276.0, "end": 2276.66, "word": " أخرى", "probability": 0.95751953125}], "temperature": 1.0}, {"id": 93, "seek": 230273, "start": 2278.78, "end": 2302.74, "text": "الـ Viroids حاجة غريبة في الحقيقة هي عبارة عن single molecule of circular RNA without a protein coat or envelope يعني مادة وراثية بس مالهاش كبسيد ولا إلها envelope و قادرة على إنها تعمل infection للنباتات، غالبا الـ Viroids بتصيبش الإنسان بتصيب اللي هو النباتة", "tokens": [6027, 39184, 691, 5182, 3742, 11331, 26108, 3660, 32771, 16572, 49401, 8978, 21542, 38436, 28671, 39896, 6225, 3555, 9640, 3660, 18871, 2167, 15582, 295, 16476, 22484, 1553, 257, 7944, 10690, 420, 19989, 37495, 22653, 3714, 18513, 3660, 4032, 2288, 5718, 104, 10632, 4724, 3794, 3714, 6027, 3224, 33599, 9122, 3555, 3794, 25708, 49429, 11933, 1211, 11296, 19989, 4032, 12174, 18513, 25720, 15844, 36145, 11296, 6055, 25957, 1211, 11764, 24976, 1863, 3555, 9307, 9307, 12399, 32771, 6027, 3555, 995, 2423, 39184, 691, 5182, 3742, 39894, 9381, 1829, 3555, 8592, 33688, 1863, 3794, 7649, 39894, 9381, 1829, 3555, 13672, 1829, 31439, 28239, 3555, 9307, 3660], "avg_logprob": -0.16526441619946405, "compression_ratio": 1.5375494071146245, "no_speech_prob": 0.0, "words": [{"start": 2278.78, "end": 2279.1, "word": "الـ", "probability": 0.806396484375}, {"start": 2279.1, "end": 2279.64, "word": " Viroids", "probability": 0.7764485677083334}, {"start": 2279.64, "end": 2280.66, "word": " حاجة", "probability": 0.9708658854166666}, {"start": 2280.66, "end": 2280.96, "word": " غريبة", "probability": 0.9876302083333334}, {"start": 2280.96, "end": 2281.1, "word": " في", "probability": 0.335693359375}, {"start": 2281.1, "end": 2281.52, "word": " الحقيقة", "probability": 0.9943033854166666}, {"start": 2281.52, "end": 2282.02, "word": " هي", "probability": 0.359375}, {"start": 2282.02, "end": 2282.48, "word": " عبارة", "probability": 0.9976806640625}, {"start": 2282.48, "end": 2282.88, "word": " عن", "probability": 0.9970703125}, {"start": 2282.88, "end": 2284.38, "word": " single", "probability": 0.580078125}, {"start": 2284.38, "end": 2284.88, "word": " molecule", "probability": 0.87646484375}, {"start": 2284.88, "end": 2285.08, "word": " of", "probability": 0.9541015625}, {"start": 2285.08, "end": 2285.58, "word": " circular", "probability": 0.576171875}, {"start": 2285.58, "end": 2286.36, "word": " RNA", "probability": 0.927734375}, {"start": 2286.36, "end": 2287.06, "word": " without", "probability": 0.84912109375}, {"start": 2287.06, "end": 2287.5, "word": " a", "probability": 0.97314453125}, {"start": 2287.5, "end": 2287.9, "word": " protein", "probability": 0.93408203125}, {"start": 2287.9, "end": 2288.34, "word": " coat", "probability": 0.98046875}, {"start": 2288.34, "end": 2288.62, "word": " or", "probability": 0.83837890625}, {"start": 2288.62, "end": 2289.2, "word": " envelope", "probability": 0.8291015625}, {"start": 2289.2, "end": 2290.1, "word": " يعني", "probability": 0.843505859375}, {"start": 2290.1, "end": 2290.48, "word": " مادة", "probability": 0.9674479166666666}, {"start": 2290.48, "end": 2291.22, "word": " وراثية", "probability": 0.89296875}, {"start": 2291.22, "end": 2291.54, "word": " بس", "probability": 0.962158203125}, {"start": 2291.54, "end": 2292.08, "word": " مالهاش", "probability": 0.81658935546875}, {"start": 2292.08, "end": 2292.94, "word": " كبسيد", "probability": 0.6888427734375}, {"start": 2292.94, "end": 2293.44, "word": " ولا", "probability": 0.70166015625}, {"start": 2293.44, "end": 2293.72, "word": " إلها", "probability": 0.8006184895833334}, {"start": 2293.72, "end": 2294.3, "word": " envelope", "probability": 0.865234375}, {"start": 2294.3, "end": 2294.94, "word": " و", "probability": 0.93310546875}, {"start": 2294.94, "end": 2295.58, "word": " قادرة", "probability": 0.8292643229166666}, {"start": 2295.58, "end": 2296.2, "word": " على", "probability": 0.796875}, {"start": 2296.2, "end": 2296.52, "word": " إنها", "probability": 0.93310546875}, {"start": 2296.52, "end": 2296.96, "word": " تعمل", "probability": 0.9440104166666666}, {"start": 2296.96, "end": 2297.66, "word": " infection", "probability": 0.88916015625}, {"start": 2297.66, "end": 2299.32, "word": " للنباتات،", "probability": 0.7633870442708334}, {"start": 2299.32, "end": 2299.58, "word": " غالبا", "probability": 0.974365234375}, {"start": 2299.58, "end": 2299.74, "word": " الـ", "probability": 0.559326171875}, {"start": 2299.74, "end": 2300.14, "word": " Viroids", "probability": 0.89208984375}, {"start": 2300.14, "end": 2300.46, "word": " بتصيبش", "probability": 0.89970703125}, {"start": 2300.46, "end": 2300.8, "word": " الإنسان", "probability": 0.970703125}, {"start": 2300.8, "end": 2301.28, "word": " بتصيب", "probability": 0.9671630859375}, {"start": 2301.28, "end": 2301.6, "word": " اللي", "probability": 0.940673828125}, {"start": 2301.6, "end": 2301.9, "word": " هو", "probability": 0.99462890625}, {"start": 2301.9, "end": 2302.74, "word": " النباتة", "probability": 0.9317626953125}], "temperature": 1.0}, {"id": 94, "seek": 232087, "start": 2304.17, "end": 2320.87, "text": "والجزء الأخير من الـ atypical virus-like particles اللي هي الـ prions و الـ prions الحقيقة صدمة و نقلة نوعية كبيرة في العلوم الحياتية لأنها أثبتت لنا أن هناك بعض البروتينات", "tokens": [2407, 6027, 7435, 11622, 38207, 16247, 9778, 13546, 9154, 2423, 39184, 412, 88, 34061, 5752, 12, 4092, 10007, 13672, 1829, 39896, 2423, 39184, 582, 626, 4032, 2423, 39184, 582, 626, 21542, 38436, 28671, 20328, 40448, 3660, 4032, 8717, 4587, 37977, 8717, 45367, 10632, 9122, 3555, 48923, 8978, 18863, 1211, 20498, 21542, 1829, 9307, 10632, 5296, 33456, 11296, 5551, 12984, 3555, 2655, 2655, 5296, 8315, 14739, 34105, 4117, 45030, 11242, 2423, 26890, 35473, 9957, 9307], "avg_logprob": -0.1978125047683716, "compression_ratio": 1.5, "no_speech_prob": 0.0, "words": [{"start": 2304.17, "end": 2305.17, "word": "والجزء", "probability": 0.91162109375}, {"start": 2305.17, "end": 2305.59, "word": " الأخير", "probability": 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"probability": 0.6881103515625}, {"start": 2311.17, "end": 2311.57, "word": " prions", "probability": 0.861328125}, {"start": 2311.57, "end": 2312.83, "word": " الحقيقة", "probability": 0.97509765625}, {"start": 2312.83, "end": 2313.79, "word": " صدمة", "probability": 0.95947265625}, {"start": 2313.79, "end": 2314.01, "word": " و", "probability": 0.9951171875}, {"start": 2314.01, "end": 2314.31, "word": " نقلة", "probability": 0.9373372395833334}, {"start": 2314.31, "end": 2314.83, "word": " نوعية", "probability": 0.9801432291666666}, {"start": 2314.83, "end": 2315.41, "word": " كبيرة", "probability": 0.9876302083333334}, {"start": 2315.41, "end": 2315.97, "word": " في", "probability": 0.86376953125}, {"start": 2315.97, "end": 2316.47, "word": " العلوم", "probability": 0.97216796875}, {"start": 2316.47, "end": 2317.35, "word": " الحياتية", "probability": 0.98828125}, {"start": 2317.35, "end": 2318.13, "word": " لأنها", "probability": 0.729248046875}, {"start": 2318.13, "end": 2318.67, 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"word": " وعن", "probability": 0.8055013020833334}, {"start": 2378.96, "end": 2379.2, "word": " طريق", "probability": 0.9969075520833334}, {"start": 2379.2, "end": 2379.32, "word": " ال", "probability": 0.9833984375}, {"start": 2379.32, "end": 2379.58, "word": " auto", "probability": 0.40087890625}, {"start": 2379.58, "end": 2380.26, "word": "-claving", "probability": 0.6592610677083334}], "temperature": 1.0}, {"id": 98, "seek": 241078, "start": 2381.84, "end": 2410.78, "text": "بنفهم انه صار على قائمة المقاومة للحرارة المقاومة للحرارة صار عندنا الـ Prions وبعدين هنتكلم عن ال Indospore Forming تمام؟ اللي هنتكلم عن ال Indospore Forming هنتكلم عن ليه ال Prions؟ و ال Prions طبعا هي المسئولة عن إحداث الأمراض الخطيرة اللي مثل ال Transmissible Spongiform Encephalopathy أو اللي احنا بنسميه جنون البقر Mad Cow Disease وفيه مقابل", "tokens": [3555, 1863, 5172, 16095, 16472, 3224, 20328, 9640, 15844, 12174, 16373, 46007, 9673, 4587, 995, 20498, 3660, 24976, 5016, 2288, 9640, 3660, 9673, 4587, 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"end": 2543.2, "word": " confirmation", "probability": 0.95166015625}, {"start": 2543.2, "end": 2543.78, "word": " اللي", "probability": 0.95361328125}, {"start": 2543.78, "end": 2543.88, "word": " هو", "probability": 0.9951171875}, {"start": 2543.88, "end": 2544.38, "word": " الشكل", "probability": 0.988037109375}, {"start": 2544.38, "end": 2545.24, "word": " الخاص", "probability": 0.970703125}, {"start": 2545.24, "end": 2545.62, "word": " بال", "probability": 0.7607421875}, {"start": 2545.62, "end": 2546.3, "word": " ال", "probability": 0.193359375}, {"start": 2546.3, "end": 2546.56, "word": " brain", "probability": 0.07470703125}, {"start": 2546.56, "end": 2546.76, "word": " هل", "probability": 0.877685546875}, {"start": 2546.76, "end": 2546.9, "word": " هو", "probability": 0.99365234375}, {"start": 2546.9, "end": 2547.24, "word": " normal", "probability": 0.818359375}, {"start": 2547.24, "end": 2547.52, "word": " ولا", "probability": 0.93896484375}, {"start": 2547.52, "end": 2548.38, "word": " abnormal", "probability": 0.83154296875}, {"start": 2548.38, "end": 2548.8, "word": " هو", "probability": 0.888671875}, {"start": 2548.8, "end": 2549.58, "word": " المسئول", "probability": 0.9249267578125}, {"start": 2549.58, "end": 2550.12, "word": " وبهك", "probability": 0.6563313802083334}, {"start": 2550.12, "end": 2550.22, "word": " ان", "probability": 0.84423828125}, {"start": 2550.22, "end": 2550.32, "word": " شاء", "probability": 0.94482421875}, {"start": 2550.32, "end": 2550.32, "word": " الله", "probability": 0.96044921875}, {"start": 2550.32, "end": 2550.56, "word": " بنكون", "probability": 0.685546875}, {"start": 2550.56, "end": 2550.9, "word": " انتهينا", "probability": 0.8426513671875}, {"start": 2550.9, "end": 2551.12, "word": " من", "probability": 0.982421875}, {"start": 2551.12, "end": 2551.48, "word": " الجزء", "probability": 0.9651692708333334}, {"start": 2551.48, "end": 2551.88, "word": " الأول", "probability": 0.879150390625}, {"start": 2551.88, "end": 2552.24, "word": " من", "probability": 0.96044921875}, {"start": 2552.24, "end": 2552.96, "word": " محاضرتنا", "probability": 0.840576171875}, {"start": 2552.96, "end": 2553.3, "word": " ليها", "probability": 0.851806640625}, {"start": 2553.3, "end": 2553.68, "word": " ال", "probability": 0.87646484375}, {"start": 2553.68, "end": 2554.06, "word": " structure", "probability": 0.63720703125}, {"start": 2554.06, "end": 2554.56, "word": " of", "probability": 0.97412109375}, {"start": 2554.56, "end": 2555.34, "word": " viruses", "probability": 0.63525390625}, {"start": 2555.34, "end": 2555.58, "word": " وان", "probability": 0.717529296875}, {"start": 2555.58, "end": 2555.66, "word": " شاء", "probability": 0.98583984375}, {"start": 2555.66, "end": 2555.72, "word": " الله", "probability": 0.95654296875}, {"start": 2555.72, "end": 2556.0, "word": " نكمل", "probability": 0.9298502604166666}, {"start": 2556.0, "end": 2556.32, "word": " المرة", "probability": 0.800048828125}, {"start": 2556.32, "end": 2557.06, "word": " القادمة", "probability": 0.9931640625}, {"start": 2557.06, "end": 2557.82, "word": " وهيكون", "probability": 0.8533935546875}, {"start": 2557.82, "end": 2558.4, "word": " موضوعنا", "probability": 0.99560546875}], "temperature": 1.0}, {"id": 105, "seek": 256107, "start": 2558.57, "end": 2561.07, "text": "عن الـ replication of virus", "tokens": [3615, 1863, 2423, 39184, 39911, 295, 5752], "avg_logprob": -0.1787109337747097, "compression_ratio": 0.7804878048780488, "no_speech_prob": 0.0, "words": [{"start": 2558.57, "end": 2559.21, "word": "عن", "probability": 0.904052734375}, {"start": 2559.21, "end": 2559.55, "word": " الـ", "probability": 0.89501953125}, {"start": 2559.55, "end": 2559.99, "word": " replication", "probability": 0.41748046875}, {"start": 2559.99, "end": 2560.51, "word": " of", "probability": 0.97998046875}, {"start": 2560.51, "end": 2561.07, "word": " virus", "probability": 0.9111328125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2561.37, "duration_after_vad": 2455.178749999988}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/A3bS_ezaB7Y.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/A3bS_ezaB7Y.srt
new file mode 100644
index 0000000000000000000000000000000000000000..733f56d83e85610a7ad199e758f00ee787748650
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/A3bS_ezaB7Y.srt
@@ -0,0 +1,2259 @@
+1
+00:00:20,990 --> 00:00:24,770
+بسم الله الرحمن الرحيم ما زلنا في الفصل المعنون
+
+2
+00:00:24,770 --> 00:00:28,050
+بـClassification of Medically Important Viruses
+
+3
+00:00:28,050 --> 00:00:32,270
+وعشان تكتمل الصورة لابد من مراجعة سريعة لهذا الفصل
+
+4
+00:00:32,270 --> 00:00:35,450
+بما يعني بدأنا  المرة الماضية احنا قلنا أن
+
+5
+00:00:35,450 --> 00:00:39,950
+التصنيف فيه معتمد على حاجتين رئيسيتين وهي المادة
+
+6
+00:00:39,950 --> 00:00:43,910
+الوراثية و الـ capsid  و الـ capsid تكلمنا عن عناصر
+
+7
+00:00:43,910 --> 00:00:47,270
+داخلها وجدنا مثلًا الـ size و الـ symmetry ووجود أو 
+
+8
+00:00:47,270 --> 00:00:51,820
+عدم وجود اللي هو الـ envelope وبعدين بالحديث عن الـ
+
+9
+00:00:51,820 --> 00:00:56,460
+classification بناء على المادة الوراثية المصنفة من
+
+10
+00:00:56,460 --> 00:01:01,400
+الـ DNA وقلنا أنه ستة مجموعات مهمة درسناها بشيء
+
+11
+00:01:01,400 --> 00:01:05,840
+من الاختصار و بشيء من التفصيل أيضًا لا يرتقي إلى
+
+12
+00:01:05,840 --> 00:01:10,900
+التفصيل المراد لكن هي مقدمة كما ذكرنا وليس تفصيل
+
+13
+00:01:10,900 --> 00:01:14,980
+كلان معنى الـ Parvo virus, Papuva viruses و الـ
+
+14
+00:01:14,980 --> 00:01:18,820
+Adenoviruses الـ Hepadna viruses و الـ Pox viruses
+
+15
+00:01:19,690 --> 00:01:24,330
+وقلنا من أجمل الأشياء في التصنيف هو حفظ
+
+16
+00:01:24,330 --> 00:01:29,650
+الاستثناءات يعني الاستثناءات، العموميات سهلة لكن بلال 
+
+17
+00:01:29,650 --> 00:01:33,050
+الموضوع الاستثناءات هي اللي بتساعد مثل الـ Pox
+
+18
+00:01:33,050 --> 00:01:36,810
+virus لجينا أنه استثنائي بأنه complex استثنائي
+
+19
+00:01:36,810 --> 00:01:43,010
+بأنه بيتكاثر في الـ cytoplasm مش في الـ nucleus وايضًا
+
+20
+00:01:43,010 --> 00:01:46,550
+طرقنا إلى تصنيف من خلال الـ diagram وعرفنا بالفعل
+
+21
+00:01:46,550 --> 00:01:50,880
+أنه We can classify DNA virus is based on the
+
+22
+00:01:50,880 --> 00:01:55,840
+presence of or absence of envelope زي مثلًا الـ ..
+
+23
+00:01:55,840 --> 00:01:59,880
+الـ .. الـ Herpes virus و الـ Hepadna virus و الـ .. الـ
+
+24
+00:01:59,880 --> 00:02:02,880
+.. الـ Pox viruses كانت كلها enveloped و الباقيين
+
+25
+00:02:02,880 --> 00:02:07,480
+كانوا naked virus و أترقنا للفيروسات بشكل سريع
+
+26
+00:02:07,480 --> 00:02:12,480
+الـ Parvovirus عرفنا فيه نوعين defective و non-defective و الـ
+
+27
+00:02:12,480 --> 00:02:17,240
+Non-defective تحدثنا عن الـ B19 فيروس اللي بيعمل
+
+28
+00:02:17,240 --> 00:02:22,280
+Slab Chick Syndrome إذا بتذكره وسمينا اسم ثاني
+
+29
+00:02:22,280 --> 00:02:26,260
+بيقولنا الـ Fifth disease أو المرض الخامس الـ Papuva
+
+30
+00:02:26,260 --> 00:02:30,740
+فيروس عرفنا أنه مختصر من كلمة Papilloma, Polioma
+
+31
+00:02:30,740 --> 00:02:34,300
+و Semi-invacuating virus و التلاتة بيقولنا عنهم
+
+32
+00:02:34,300 --> 00:02:37,500
+بيعملوا tumors اتنين بيعملوا tumors في الحيوانات
+
+33
+00:02:37,500 --> 00:02:40,660
+واحد بيعمل tumor في الإنسان اللي هو الـ Papilloma
+
+34
+00:02:40,660 --> 00:02:45,400
+virus أيضًا طرحنا لفيروس اسمه Adenovirus و الـ
+
+35
+00:02:45,400 --> 00:02:49,260
+Adenovirus كان من الفيروسات الشهيرة خاصة في
+
+36
+00:02:49,260 --> 00:02:53,260
+الطفولة لأنه بيعمل الـ Pharyngitis وهو Very common
+
+37
+00:02:53,260 --> 00:02:59,470
+in children الـ Hepadna viruses أخذنا مثال واحد عليها
+
+38
+00:02:59,470 --> 00:03:03,250
+اللي هو الـ Hepatitis B virus واتكلمنا عن الـ
+
+39
+00:03:03,250 --> 00:03:07,870
+uniqueness التفرد تبع هذا الـ virus من حيث التركيب
+
+40
+00:03:07,870 --> 00:03:11,530
+قلنا إنه عبارة عن Circle لكن هذا الـ Circle مش
+
+41
+00:03:11,530 --> 00:03:15,890
+complete لا complete في إنه البداية ترتبط مع
+
+42
+00:03:15,890 --> 00:03:20,170
+النهاية ولا complete بإنه Double strand مكتمل الـ
+
+43
+00:03:20,170 --> 00:03:22,530
+.. الـ .. الـ .. الـ strand الـ .. الـ complementary
+
+44
+00:03:22,530 --> 00:03:30,010
+للأصلي بالضبط لا يتعدى لـ 25% من حجم الـ genome الـ
+
+45
+00:03:30,010 --> 00:03:33,350
+Herpes virus family اتفقنا أنها مجموعة كبيرة أيضًا
+
+46
+00:03:33,350 --> 00:03:37,190
+وهذه المجموعة تحتوي على عناصر مهمة من الـ
+
+47
+00:03:37,190 --> 00:03:39,510
+Medically important viruses زي الـ Herpes simplex
+
+48
+00:03:39,510 --> 00:03:43,310
+type 1, type 2, Varicella zoster, الـ
+
+49
+00:03:43,310 --> 00:03:47,010
+Cytomegalovirus و الـ Epstein Barr virus و أفرادها لها
+
+50
+00:03:47,010 --> 00:03:52,390
+لوحة خاصة بتمتلك بعض الخصائص اللي هي مثلًا الـ
+
+51
+00:03:52,390 --> 00:03:58,480
+latency ما تحدثنا عن الـ latency إلا لهذه المجموعة
+
+52
+00:03:58,480 --> 00:04:01,080
+واتكلمنا عن مرض من اللي بتسببه اللي هو الـ
+
+53
+00:04:01,080 --> 00:04:04,500
+Infectious mononucleosis وذكرنا أن هذا مرض خطير
+
+54
+00:04:04,500 --> 00:04:08,520
+بسبب الـ Epstein-Barr virus الأخير في السلسلة كان
+
+55
+00:04:08,520 --> 00:04:14,810
+اللي هو الـ Pox viruses و الـ Pox virus استحدثنا أيضًا
+
+56
+00:04:14,810 --> 00:04:19,170
+عن انتهاءها من كوكب الأرض بالأحرى الـ Small pox
+
+57
+00:04:19,170 --> 00:04:24,770
+virus بوسط أخوه اللي هو الـ vaccine اللي كان بالفعل
+
+58
+00:04:24,770 --> 00:04:28,870
+انطلاقة لعلم اللي هو الـ vaccination أو التطييب
+
+59
+00:04:28,870 --> 00:04:34,950
+اللي ساهم بشكل كبير جدا في خفض عدد الوفيات من
+
+60
+00:04:34,950 --> 00:04:38,810
+الأمراض المعدية بدا أعطيكوا بس مدام ذكرنا هذا
+
+61
+00:04:38,810 --> 00:04:44,840
+المعلومة أعطيكوا معلومة مهمة قبل 100 عام من هذا
+
+62
+00:04:44,840 --> 00:04:52,600
+التاريخ لو حاولنا قراءة نسب الوفيات للأمراض
+
+63
+00:04:52,600 --> 00:04:58,300
+المختلفة من خلال الـ bio chart الكعكة تمام؟ هتلاجي أن
+
+64
+00:04:58,300 --> 00:05:03,740
+53% من نسب الوفيات كانت لصالح من الأمراض المعدية،
+
+65
+00:05:03,740 --> 00:05:06,780
+لما أقول أمراض معديّة يعني فيروسات، بكتيريا،
+
+66
+00:05:06,780 --> 00:05:10,680
+فطريات، طفيليات، إلى آخره عارفين جدش اليوم بتشكل
+
+67
+00:05:10,680 --> 00:05:15,300
+من الكعك العالمي اللي هو فيه فقط تلاتة بالمائة،
+
+68
+00:05:15,300 --> 00:05:19,340
+من تلاتة و خمسين بالمائة انخفض إلى تلاتة بالمائة،
+
+69
+00:05:19,340 --> 00:05:23,420
+هذا بفضل الله سبحانه وتعالى أولًا وآخرًا، ثم بفضل
+
+70
+00:05:23,420 --> 00:05:27,540
+حاجتين رئيسيتين الـ Vaccination اللي هو التطييم اللي
+
+71
+00:05:27,540 --> 00:05:32,380
+هنتكلم عنه و استخدام الـ Antibiotics طبعًا فيه كمان
+
+72
+00:05:32,380 --> 00:05:37,460
+سبب تالت يعني لا يقل أهمية لكن لا يذكر لإنه هو كان
+
+73
+00:05:37,460 --> 00:05:42,020
+تقدم عام للبشر كلهم اللي هي النظافة العامة النظافة
+
+74
+00:05:42,020 --> 00:05:46,960
+العامة إذن الـ Vaccination كانت من المساهمين الكبار
+
+75
+00:05:46,960 --> 00:05:50,360
+في مين؟ في إقلال نسبة نسبة الوفيات من الأمراض
+
+76
+00:05:50,360 --> 00:05:56,430
+المعدية ثم انتقلنا إلى الـ RNA viruses وانتقلنا للـ
+
+77
+00:05:56,430 --> 00:06:00,870
+RNA viruses أوضحتنا بشكل لا لبس فيه بأن الـ RNA
+
+78
+00:06:00,870 --> 00:06:07,250
+viruses أكثر عددًا من الـ DNA virus و زي ما هناك كان
+
+79
+00:06:07,250 --> 00:06:11,510
+في استثناء بأنه Single stranded DNA هنا فيه
+
+80
+00:06:11,510 --> 00:06:16,850
+استثناء Double stranded DNA لصالح مين؟ الـ Reo virus
+
+81
+00:06:16,850 --> 00:06:23,320
+هنا لكن التصنيف معقدة واحنا لجأنا للجداول
+
+82
+00:06:23,320 --> 00:06:27,440
+وحمّورنا على الجداول بشكل برضه سريع عشان نستكمل
+
+83
+00:06:27,440 --> 00:06:32,520
+إجراءاتنا كنا بكورونا فيروس و سمينا بيكو small RNA
+
+84
+00:06:32,520 --> 00:06:37,060
+فيروس وعليه مثال الـ Polio و الـ Rhino و الـ Hepatitis
+
+85
+00:06:37,060 --> 00:06:44,460
+فيروس Calici virus Reo virus و Flavi virus الـ Flavi
+
+86
+00:06:44,460 --> 00:06:47,300
+اللي بتقول عنها الـ Flavi اللي هي الصفراء الـ Flavi
+
+87
+00:06:47,300 --> 00:06:50,280
+اللي هي الصفراء و الـ Reo اللي احنا اصلا جايبينه شوية
+
+88
+00:06:50,280 --> 00:06:53,020
+اللي كنا بنتكلم عنه هو استثناء وعلى فكرة استثنائياته
+
+89
+00:06:53,020 --> 00:07:00,700
+كثيرة وهنشوف لما نطلع على الفقرة الخاص بالـ Reo virus
+
+90
+00:07:00,700 --> 00:07:03,660
+أنه الفئة الاستثنائي فيه أمور كثيرة
+
+91
+00:07:22,660 --> 00:07:24,060
+والالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالال
+
+92
+00:07:27,140 --> 00:07:30,260
+أصلًا هو مش .. مش .. مش نوع واحد وهنشوف أنه .. أنه
+
+93
+00:07:30,260 --> 00:07:34,760
+بينتمي إليه مجموعات من الفيروسات مهمة جدا مثلًا
+
+94
+00:07:34,760 --> 00:07:39,220
+الـ Orthomyxovirus اللي بيضم فيهم الـ Influenza virus
+
+95
+00:07:39,220 --> 00:07:42,800
+ممتاز الـ Influenza virus أنا ممكن أعرف إذا كنت
+
+96
+00:07:42,800 --> 00:07:45,680
+المرة الماضية ولا قلتلكوا أنه الـ Influenza virus
+
+97
+00:07:45,680 --> 00:07:50,760
+من الفيروسات القاتلة والتي تاريخيًا سجلت حالات قتل
+
+98
+00:07:50,760 --> 00:07:54,820
+عديدة أنتم بتعرفوا أن نسبة الوفيات من الـ .. من الـ
+
+99
+00:07:54,820 --> 00:08:00,910
+Influenza العادية حوالي نص بالمائة وقد تصل إلى خمسة
+
+100
+00:08:00,910 --> 00:08:05,470
+بالمائة، من نص إلى خمسة بالمائة وأن عدد الوفيات من
+
+101
+00:08:05,470 --> 00:08:09,750
+الـ Influenza الإسبانية حوالي أربعين مليون حالة
+
+102
+00:08:09,750 --> 00:08:12,870
+وفاة في سنة ألف وتسعمائة وأربعة عشر وهذا العدد في
+
+103
+00:08:12,870 --> 00:08:18,000
+حينه .. في حينه كان أكبر من عدد تعداد من قُتل في
+
+104
+00:08:18,000 --> 00:08:21,060
+الحرب العالمية الأولى والثانية والحرب الأمريكية
+
+105
+00:08:21,060 --> 00:08:25,660
+الفيتناميه، إذن الإنفلوانزا مرض خطير و يفاجئنا كل
+
+106
+00:08:25,660 --> 00:08:29,700
+فترة وفترة بسلالت شرسة بالفعل تحدث وفيات، كان
+
+107
+00:08:29,700 --> 00:08:35,400
+آخرها إنفلوانزا الطيور وإنفلوانزا الخنازير الـ Rhabdo
+
+108
+00:08:35,400 --> 00:08:38,460
+فيروس وهي الفيروسات اللي ذكرنا عنها المرة الماضية
+
+109
+00:08:38,460 --> 00:08:43,940
+بتسبب قولنا ده في الكلب وسميت Rhabdo من الشكل تبع
+
+110
+00:08:43,940 --> 00:08:46,520
+الفيروس اللي هو عامل زي الرصاصة أو الـ Bullet
+
+111
+00:08:46,520 --> 00:08:51,920
+الـ Filo virus من شكله الخيطي و الخيطي لأنه أنا
+
+112
+00:08:51,920 --> 00:08:56,260
+أذكركوا مرة أخرى أنه رأينا هذا الشكل في مقدمة الـ
+
+113
+00:08:56,260 --> 00:08:58,620
+Biology لما طلعنا على أشكال الفيروسات لجينا فيروس
+
+114
+00:08:58,620 --> 00:09:02,460
+عامل زي الدودة الورم اللي هو الـ Ebola Virus طبعًا
+
+115
+00:09:02,460 --> 00:09:05,640
+فيه الواخو ثاني اسمه Marburg Virus برضه نزل على
+
+116
+00:09:05,640 --> 00:09:12,180
+الصحة الطبية الـ Coronavirus الـ Arena Virus طبعًا الـ
+
+117
+00:09:12,180 --> 00:09:16,380
+Corona و هناك في السعودية الآن بلفلف فيها فيروس اسمه
+
+118
+00:09:16,380 --> 00:09:20,520
+Merskov Virus Merskov Middle East Respiratory
+
+119
+00:09:20,520 --> 00:09:26,100
+Virus أو و Co جاءت من كلمة Corona و Corona اشتهرت
+
+120
+00:09:26,100 --> 00:09:31,790
+بشغلتين بالرشح العادي اللي هو الـ Common cold يبقى
+
+121
+00:09:31,790 --> 00:09:36,670
+الـ Common cold مرض لا يسببه فيروس واحد أكثر من
+
+122
+00:09:36,670 --> 00:09:41,910
+فيروس هذه نقطة كتير مهمة مثلًا الـ Rhinovirus الـ
+
+123
+00:09:41,910 --> 00:09:46,150
+Rhinovirus هو المسبب الأساسي للرشح لكن مسبب آخر
+
+124
+00:09:46,150 --> 00:09:52,030
+هو الـ Coronavirus فيه هنا الـ .. الـ .. الـ SARS و الـ
+
+125
+00:09:52,030 --> 00:09:56,230
+SARS من الـ .. الـ .. الـ Coronavirus اللي بالفعل 
+
+126
+00:09:56,230 --> 00:10:00,150
+اكتسبت publicity عالية في السنوات الأخيرة عندما
+
+127
+00:10:00,150 --> 00:10:04,550
+انتشر في Hong Kong و ارتبط بنا ببعض أنواع من القطر
+
+128
+00:10:04,880 --> 00:10:07,700
+الارينا فيروس اشتهر لدينا الآن احنا في ال
+
+129
+00:10:07,700 --> 00:10:10,880
+microbiology هنا أو في ال virology اشتهر لدينا
+
+130
+00:10:10,880 --> 00:10:15,980
+بأنه يحتوي على ريبوزومز هو الوحيد وكلمة ارينا
+
+131
+00:10:15,980 --> 00:10:19,960
+قلنا لكم أنه رمل رمل يعني في الحلبة والريبوزوم
+
+132
+00:10:19,960 --> 00:10:24,980
+عاملة زي الـ sand في هذا الفيروس البنيا فيروس من
+
+133
+00:10:24,980 --> 00:10:31,120
+أخطر الفيروسات أيضًا California encephalitis virus
+
+134
+00:10:31,120 --> 00:10:34,750
+اللي أنا بقول encephalitis يعني التهاب الدماغ فيه
+
+135
+00:10:34,750 --> 00:10:37,250
+كمان هانتا فيروس أيضًا من الفيروسات الخطيرة
+
+136
+00:10:37,250 --> 00:10:41,290
+الميكروب الأخير في السلسلة اللي عندنا اللي هو الـ
+
+137
+00:10:41,290 --> 00:10:46,470
+Delta virus وبرضه هذا الفيروس أصبح شهير لديكم، صح؟
+
+138
+00:10:46,470 --> 00:10:50,170
+اللي هو الـ defective أو الـ D الهيبوتايتس D اللي
+
+139
+00:10:50,170 --> 00:10:53,810
+كنا لازمه به عشان يقدر يعمل replication أو
+
+140
+00:10:53,810 --> 00:10:58,610
+infection للإنسان، الآن نعود إلى تفاصيل الفيروسات
+
+141
+00:10:58,610 --> 00:11:01,450
+كلهم يعني بتفاصيله أيضًا برضه قليلة
+
+142
+00:11:05,380 --> 00:11:09,780
+نبدأ بالـ Picorna viruses, they are the smallest of
+
+143
+00:11:09,780 --> 00:11:14,800
+not of all viruses, of RNA viruses، قد إيش تقريبًا القطر
+
+144
+00:11:14,800 --> 00:11:21,460
+تبعها ثمانية وعشرون، single-stranded linear non
+
+145
+00:11:21,460 --> 00:11:25,480
+-segmented positive polarity RNA، وطبعًا فاهمين إيش
+
+146
+00:11:25,480 --> 00:11:31,220
+يعني positive polarity، can act as an mRNA مباشرة
+
+147
+00:11:31,220 --> 00:11:36,900
+بدون أي .. يعني بدون أي complementation، أنا أكيد
+
+148
+00:11:36,900 --> 00:11:40,820
+إيكوزاهيدرال كابسيل، أنا عندي بالمناسبة برنامج
+
+149
+00:11:40,820 --> 00:11:44,280
+عملته أنا وطلبة من كلية الطب، برنامج محوسب
+
+150
+00:11:44,280 --> 00:11:49,250
+للفيرولوجي، عملته يعني على نسخة قديمة من الـ ويندوز
+
+151
+00:11:49,250 --> 00:11:51,770
+مش متأكد أنه بيشتغل على الـ .. على النسخ الحديثة
+
+152
+00:11:51,770 --> 00:11:55,250
+فبتجربه على .. على ويندوز عشر إن شاء الله وإذا كان
+
+153
+00:11:55,250 --> 00:11:58,150
+مازال يعني بيعمل على هذه الـ .. الـ .. النسخ
+
+154
+00:11:58,150 --> 00:12:04,430
+الجديدة هنزلكم إياه، هذا برنامج عبارة عن قاعدة بيانات
+
+155
+00:12:04,430 --> 00:12:09,800
+صنفنا الفيروسات عليه، كل فيروس بيطلع له صفحة، بس صفحة
+
+156
+00:12:09,800 --> 00:12:14,660
+واحدة للفيروس، وانقطعت المعلومات مقطعة وملصقة،
+
+157
+00:12:14,660 --> 00:12:17,880
+يعني يسهل حفظه، ممكن تعملوا منه تقارير، يعني يتلخص 
+
+158
+00:12:17,880 --> 00:12:21,700
+الـ .. الفيروس، كل فيروس تعمله print out كـ PDF،
+
+159
+00:12:21,700 --> 00:12:24,740
+برنامج كثير رائع فيه حينه،  أرجو أنه يكون موجود
+
+160
+00:12:24,740 --> 00:12:28,680
+مازال موجود عندي نسخ منه عشان أتيح لكم طبعًا
+
+161
+00:12:28,680 --> 00:12:32,800
+اللي خلاني أتذكر البرنامج هو الـ confusion اللي
+
+162
+00:12:32,800 --> 00:12:36,420
+ممكن يحصل للطالب في موضوع positive polarity ولا
+
+163
+00:12:36,420 --> 00:12:39,800
+negative polarity، double stranded ولا single
+
+164
+00:12:39,800 --> 00:12:44,840
+stranded، هذه المعلومات بحاجة إلى وسيلة مساعدة لإنه
+
+165
+00:12:44,840 --> 00:12:48,220
+تساعدنا في حياتنا إن شاء الله،  Picorna viruses جاي من
+
+166
+00:12:48,220 --> 00:12:54,450
+كلمة small و RNA اللي هي containing virus، two groups
+
+167
+00:12:54,450 --> 00:12:57,670
+مهمين جدًا اللي هم الـ انترو فيروس والـ رينو فيروس
+
+168
+00:12:57,670 --> 00:13:01,910
+طبعًا الـ انترو فيروس مجموعة سميت انترو لأنها بتعمل
+
+169
+00:13:01,910 --> 00:13:05,330
+infection في الـ intestinal tract، لكن لا يعني
+
+170
+00:13:05,330 --> 00:13:09,210
+بالضرورة أنهم بيشبهوا بعض في المرض، مثلًا الـ polio
+
+171
+00:13:09,210 --> 00:13:13,830
+virus في شلل الأطفال، مرض خطير جدًا وعمال العالم
+
+172
+00:13:13,830 --> 00:13:19,790
+بيحتفل لكن احتفاله ما اكتملش لإن في ضال الدولتين
+
+173
+00:13:20,510 --> 00:13:24,910
+مازال بيسجل فيهم حالات شلل الأطفال وهم Pakistan
+
+174
+00:13:24,910 --> 00:13:30,710
+وأفغانستان، طبعًا حالات قليلة جدًا لكن تمنع العالم
+
+175
+00:13:30,710 --> 00:13:33,870
+من الاحتفال بالقضاء على المرض، يعني المرض ما زال
+
+176
+00:13:33,870 --> 00:13:39,230
+موجود، فلسطين أعلنت خالية من شلل الأطفال من عدة
+
+177
+00:13:39,230 --> 00:13:43,510
+سنوات بشكل الأرقام، لكن بشكل رسمي أعتقد أن فقط قبل
+
+178
+00:13:43,510 --> 00:13:46,030
+عامين تم إعلانها من قبل منظمة الصحة العالمية أنها
+
+179
+00:13:46,030 --> 00:13:51,130
+خالية من شلل الأطفال، طبعًا ده بقول أنه هذا فضل من
+
+180
+00:13:51,130 --> 00:13:55,670
+الله سبحانه وتعالى وفضل النساء الفلسطينيات اللي
+
+181
+00:13:55,670 --> 00:13:59,870
+بيهتموا كثير في موضوع الـ vaccination لأطفالهم،
+
+182
+00:13:59,870 --> 00:14:03,610
+يعني نسبة الـ vaccination coverage تصل إلى مائة
+
+183
+00:14:03,610 --> 00:14:09,530
+بالمائة، يعني ما فيش طفل بيحارب من إيه؟ من إطة، يعني
+
+184
+00:14:09,530 --> 00:14:14,380
+ما أعرفش هل هو محبة أو انتقام يعني من الأم، هذا طيب الـ
+
+185
+00:14:14,380 --> 00:14:19,060
+انترو فيروس وجدنا بوليو فيروس وكوكساكي فيروس وإيكو
+
+186
+00:14:19,060 --> 00:14:22,200
+فيروس، التنين اللي ذكرته من الأخرانيات هو الإيكو
+
+187
+00:14:22,200 --> 00:14:27,520
+والكوكساكي فيروس are both a cause of meningitis،
+
+188
+00:14:27,520 --> 00:14:33,020
+يعني برضه سببه التهاب السحايا أيضًا Hepatitis A
+
+189
+00:14:33,020 --> 00:14:37,200
+ينتمي إلى هذه
+
+190
+00:14:37,200 --> 00:14:42,440
+المجموعة، طبعًا Hepatitis A تختلف عن B وعن C، احنا
+
+191
+00:14:42,440 --> 00:14:44,680
+قلنا لكم في مجموعة كبيرة من الـ Hepatitis وقلنا
+
+192
+00:14:44,680 --> 00:14:50,060
+لكم لا يربطها علاقة إلا الـ target اللي هم في
+
+193
+00:14:50,060 --> 00:14:52,940
+الآخر بيعملوه أو الـ disease اللي هو التهيئة الـ
+
+194
+00:14:52,940 --> 00:14:58,200
+inflammation of the liver، فمثلًا Hepatitis A و E
+
+195
+00:14:58,200 --> 00:15:04,540
+بينتقل عبر الفيكل oral بينما B بينتقل عبر الجنس و
+
+196
+00:15:04,540 --> 00:15:08,760
+عبر الدم، و C بينتقل عبر الدم بالدرجة الأولى ويقال
+
+197
+00:15:08,760 --> 00:15:14,660
+أن هناك احتمالية انتقاله بالجنس مع دوما، there are
+
+198
+00:15:14,660 --> 00:15:17,640
+two groups of human pathogen، يقول لنا الأولى الـ
+
+199
+00:15:17,640 --> 00:15:21,580
+enterovirus والتانية الـ rhinovirus، لحظة، إن واحد
+
+200
+00:15:21,580 --> 00:15:25,700
+بينتقل عبر الـ intestinal tract والتانية عبر الـ
+
+201
+00:15:25,700 --> 00:15:30,410
+respiratory، كلمة rhino أنف، معناها راينو معناها أنف
+
+202
+00:15:30,410 --> 00:15:36,250
+فالراينو هو المسبب الرئيسي للـ common cold، قبل قليل
+
+203
+00:15:36,250 --> 00:15:43,930
+عرفنا مين كورونا، كورونا virus بسبب الرشح وهي كمان
+
+204
+00:15:43,930 --> 00:15:51,590
+عندنا الـ rhino virus، Calicivirus، Calicivirus يعني
+
+205
+00:15:51,590 --> 00:15:56,110
+بنقدر نقول أنه في السنوات الأخيرة اكتسب شهرة كبيرة
+
+206
+00:15:56,110 --> 00:16:02,390
+برضه، خاصة في الدول الأوروبية وأصبح جزء رئيسي من
+
+207
+00:16:02,390 --> 00:16:08,330
+الأبحاث منصب على كيفية عزل هذا الفيروس من عينات
+
+208
+00:16:08,330 --> 00:16:13,510
+المياه، مياه الصرف طبعًا أو مياه الأنهار اللي تستخدم
+
+209
+00:16:13,510 --> 00:16:19,730
+بعد معالجة لمين؟ لمياه الصرف، من الأمثلة المهمة جدًا
+
+210
+00:16:19,730 --> 00:16:24,590
+على هذا الفيروس هو الـ Norwalk أو Norwalk Virus و
+
+211
+00:16:24,590 --> 00:16:29,130
+Hepatitis E Virus، والـ Hepatitis E Virus تم
+
+212
+00:16:29,130 --> 00:16:34,370
+تصنيفها مؤخرًا في جيناس لحالها سمّوها Hepe Virus، و
+
+213
+00:16:34,370 --> 00:16:38,150
+كلمة Hepe جاء من Hepatitis E يعني الـ E هذه
+
+214
+00:16:38,150 --> 00:16:43,590
+المضاعفة للـ Hep هي لتصنيفها كـ Hepatitis E، اسمها
+
+215
+00:16:43,590 --> 00:16:49,340
+Hepe Virus، برضه الجينوم تبعها positive polarity و
+
+216
+00:16:49,340 --> 00:16:55,920
+non-segmented وايضًا linear، الريوفيروسز تعالوا نشوف
+
+217
+00:16:55,920 --> 00:17:00,200
+من ورا إيجاء اسمها، إيجاء اسمها من ثلاث كلمات
+
+218
+00:17:00,200 --> 00:17:07,640
+respiratory enteric orphan، إيش معنى orphan؟ يتيم
+
+219
+00:17:07,640 --> 00:17:14,140
+orphan معناها يتيم، ليس مو يتيم لأنه في ذاك الوقت
+
+220
+00:17:14,140 --> 00:17:18,440
+لما سمي بهذا الاسم هو الفيروس الوحيد اللي كان يعزل
+
+221
+00:17:18,440 --> 00:17:22,580
+من مكانين في نفس الوقت اللي هم الـ respiratory
+
+222
+00:17:22,580 --> 00:17:26,680
+tract ومن الـ enteric tract، تمام؟ فجاءوا عنه
+
+223
+00:17:26,680 --> 00:17:31,480
+enteric أو respiratory enteric orphan اللي الفيروس
+
+224
+00:17:31,480 --> 00:17:35,280
+الوحيد، تمام؟ بالتالي لأن أنا أخذت أول حرف من كل
+
+225
+00:17:35,280 --> 00:17:40,820
+كلمة من ثلاث كلمات فصار عندي R E O فسمّيها Reo
+
+226
+00:17:40,820 --> 00:17:45,300
+virus، بقول لنا unique في التسمية يعني فريد بالتسمية
+
+227
+00:17:45,300 --> 00:17:50,860
+فريد بأنه يحتوي على double-stranded RNA ومش هيك
+
+228
+00:17:50,860 --> 00:17:55,040
+بس، فريد بأنه يحتوي على segmented، أكبر عدد من الـ
+
+229
+00:17:55,040 --> 00:17:58,760
+segments لحد الآن اللي عرفناها في هذا الفيروس طبعًا
+
+230
+00:17:58,760 --> 00:18:02,580
+بتكلم عن الفيروسات الطبية اللي هو الـ 10 segments
+
+231
+00:18:02,580 --> 00:18:08,770
+يليه الـ influenza كان عشرة segments، من المشهورين تحت
+
+232
+00:18:08,770 --> 00:18:13,890
+هذه العائلة أو هذا الـ genus هو الـ rotavirus والـ
+
+233
+00:18:13,890 --> 00:18:18,870
+rotavirus شهرته في العالم الثالث كثيرة نظرًا لأنه
+
+234
+00:18:18,870 --> 00:18:23,310
+بينتقل عبر الفيكل oral route، ومدينة بينتقل عبر
+
+235
+00:18:23,310 --> 00:18:27,650
+الفيكل oral route في مناطق الـ .. الـ .. الـ sewage
+
+236
+00:18:27,650 --> 00:18:32,770
+system مش مكتمل فيها والـ .. والـ sewage treatment
+
+237
+00:18:32,770 --> 00:18:39,010
+مش فعالة، مثلًا احنا هنا في قطاع غزة فينا waste
+
+238
+00:18:39,010 --> 00:18:41,790
+water treatment plants، فينا واحدة في الشيخ عجلين،
+
+239
+00:18:41,790 --> 00:18:45,410
+واحدة في رفح، واحدة في الشمال، واحدة في منطقة
+
+240
+00:18:45,410 --> 00:18:51,140
+البريج على الحدود، يعني فيه موجود، محطات معالجة
+
+241
+00:18:51,140 --> 00:18:55,320
+للأسف محطات المعالجة أنها شغالة فيها ومشكلات
+
+242
+00:18:55,320 --> 00:18:59,660
+فيها، محتاجة كهرباء والكهرباء أنها وضعها سيء لغاية
+
+243
+00:18:59,660 --> 00:19:05,260
+الحجم تبعها .. الحجم تبعها لا يتناسب مع الكميات اللي
+
+244
+00:19:05,260 --> 00:19:09,160
+بتغطي المنطقة، في بعض الأحيان بيضخ منها sewage
+
+245
+00:19:09,160 --> 00:19:14,460
+مباشرة غير معالجة على مياه البحر، وهذا طبعًا بسبب
+
+246
+00:19:14,460 --> 00:19:18,700
+المشاكل الصحية اللي تحدثنا عنها مرارًا وتكرارًا
+
+247
+00:19:18,700 --> 00:19:24,420
+إذا لا كمية كافية ولا كهرباء، والكهرباء رقم ثلاثة
+
+248
+00:19:24,420 --> 00:19:28,660
+في بعض الأحيان بنحتاج المعالجة مش معالجة واحدة، في
+
+249
+00:19:28,660 --> 00:19:32,660
+معالجة primary و secondary و tertiary، التيرشيري
+
+250
+00:19:32,660 --> 00:19:37,500
+لازم نعمل disinfection للمياه المعالجة قبل أن هو 
+
+251
+00:19:37,500 --> 00:19:42,120
+التخلص منها بعض الأحيان ما بنلاقيش المادة المستخدمة
+
+252
+00:19:42,120 --> 00:19:46,140
+في الـ disinfection بكميات كافية لوضحها وبالتالي
+
+253
+00:19:46,140 --> 00:19:50,320
+أيضا يضخ حتى وإن كانت معالجة هم سميها معالجة جزئيا
+
+254
+00:19:50,320 --> 00:19:55,120
+يعني treated, untreated or partially treated هذا
+
+255
+00:19:55,120 --> 00:20:00,760
+ما يضخ لنا على البحر فبالتالي أنا ذكرتلكوا قبل هيك
+
+256
+00:20:00,760 --> 00:20:05,350
+في هذه المناسبات أن أكبر ملوث للمياه المياه الشرب
+
+257
+00:20:05,350 --> 00:20:10,330
+والمياه الاستجمام هو المياه العادمة القادمة من
+
+258
+00:20:10,330 --> 00:20:15,970
+البشر تمام؟ والبشر يصابوا بأمراض منها فيروسية منها
+
+259
+00:20:15,970 --> 00:20:19,310
+الـ Rotavirus منها Hepatitis A منها Hepatitis E
+
+260
+00:20:19,310 --> 00:20:25,210
+وبالتالي طبعا البعض يقولك أن البحر ما هو؟ قدرته على
+
+261
+00:20:25,210 --> 00:20:30,550
+التطهير الذاتي لأنه مالح حوله أنا أقول نعم لديه
+
+262
+00:20:30,550 --> 00:20:34,470
+قدرة على التطهير الذاتي ولكن هذه القدرة محدودة
+
+263
+00:20:34,470 --> 00:20:40,150
+بعدين من يضمن لنا أنه الفيروس اللي دخل الآن في هذه
+
+264
+00:20:40,150 --> 00:20:46,170
+اللحظة هيموت في نفس اللحظة هناك variation في الـ
+
+265
+00:20:46,170 --> 00:20:50,970
+survival time للـ micro organism مثلا الإشريكية
+
+266
+00:20:50,970 --> 00:20:54,750
+الكلية ممكن تعيش عدة ساعاتالانترو كوكاس ممكن تعيش
+
+267
+00:20:54,750 --> 00:21:00,090
+عدة أيام وصل الصورة ففي اختلاف في الـ survival rate
+
+268
+00:21:00,090 --> 00:21:04,210
+وهذه تنسوش أن الـ pathogen مالهاش envelope مالهاش
+
+269
+00:21:04,210 --> 00:21:07,370
+envelope قدرتها على البقاء في الـ environment بتكون
+
+270
+00:21:07,370 --> 00:21:11,810
+مالها أعلى من الـ envelope virus طيب في كمان نقطتان
+
+271
+00:21:11,810 --> 00:21:16,070
+لازم نحكيها عن الـ rotavirus أنه له vaccine اللي هو
+
+272
+00:21:16,070 --> 00:21:20,850
+vaccine وقومني دخل العام الماضي إلى فلسطين
+
+273
+00:21:20,850 --> 00:21:25,390
+rotavirus وأنا من هنا بسأل السؤال بقول أن أنتو
+
+274
+00:21:25,390 --> 00:21:30,670
+بتعرفوا أثمان التطعيمات بتكون مرتفعة يعني لو
+
+275
+00:21:30,670 --> 00:21:35,090
+تحدثنا عن خمس دولار للجرعة الواحدة وخلينا خمسين
+
+276
+00:21:35,090 --> 00:21:41,570
+ألف طفل بيولد سنويا خمسين في خمسة احسبوا الرقم إذا
+
+277
+00:21:41,570 --> 00:21:46,530
+كان أكثر من جرعة مايضرو في اثنين فالارقام المالية
+
+278
+00:21:46,530 --> 00:21:51,930
+المترتبة على ادخال تطعيمات جديدة هي أرقام ضخمة هل
+
+279
+00:21:53,040 --> 00:21:56,620
+قمنا باتخاذ الـ vaccine بناء على دراسة عرفنا جداش
+
+280
+00:21:56,620 --> 00:22:01,260
+بالفعل الـ Rotavirus بيساهم في إمراض الأطفال اللي
+
+281
+00:22:01,260 --> 00:22:08,040
+عندنا في فلسطين، ما عرفناش، طيب، واحد بيقول طيب حتى
+
+282
+00:22:08,040 --> 00:22:11,700
+لو كانوا Gynecologist ما هو الرقم اللي بندفع
+
+283
+00:22:11,700 --> 00:22:15,660
+المصاري، هذا بدي يحمي أطفالنا، صحيح، لدينا أولويات
+
+284
+00:22:15,660 --> 00:22:19,060
+يا جماعة، لدينا أولويات، يعني لو المبلغ هذا تم
+
+285
+00:22:19,060 --> 00:22:26,910
+صرفه في اتجاه آخر، يوفر علي أمراض أخرى بـ مضاعفات
+
+286
+00:22:26,910 --> 00:22:32,390
+أصعب بنسب وفيات أعلى يمكن يكون هذا التوجه أفضل
+
+287
+00:22:32,390 --> 00:22:37,970
+لذلك احنا بنقول وبنشجع أن بالفعل أي قرارات سياسية
+
+288
+00:22:37,970 --> 00:22:43,650
+صحية تقريبا تكون مبنية على دراسات محلية وليس
+
+289
+00:22:43,650 --> 00:22:48,370
+دراسات أجنبية وكان في مثال صعب للغاية لما في 2011
+
+290
+00:22:48,370 --> 00:22:51,030
+أدخله الـ vaccine تبع الـ
+
+291
+00:22:54,430 --> 00:22:59,290
+دراسات روحنا نعمل دراسة نشوف ماذا تأثير على
+
+292
+00:22:59,290 --> 00:23:03,430
+الـ vaccine قبل يعني إيه إيه لما دخلنا إيش صار في
+
+293
+00:23:03,430 --> 00:23:07,170
+الـ ستربتو كوكاس نيمونيا بعد فلما روحنا ندور على
+
+294
+00:23:07,170 --> 00:23:12,670
+سجلات قبل ما لاقيناش ستربتو كوكاس نيمونيا ولا بعد
+
+295
+00:23:12,670 --> 00:23:17,370
+لاقينا فالمهم أن أصلا أدخل الـ vaccine دون ما
+
+296
+00:23:17,370 --> 00:23:23,060
+الحاجة لهذا الـ vaccine بناء على توقعات أو بناء على
+
+297
+00:23:23,060 --> 00:23:31,340
+توصيات من أماكن أخرى غير فلسطين لذلك نقول أي تغيير
+
+298
+00:23:31,340 --> 00:23:36,480
+أو أي intervention صحي كسياسة عامة لابد أن يكون
+
+299
+00:23:36,480 --> 00:23:42,950
+مبني على دراسات ونتائج دراسات محلية الفلاجو فيروس
+
+300
+00:23:42,950 --> 00:23:47,690
+من أشهر أمثلته اللي هم الـ yellow fever virus و الـ
+
+301
+00:23:47,690 --> 00:23:51,670
+dingy أو الـ dingy virus وقلنا لك الـ dengue virus اسمه
+
+302
+00:23:51,670 --> 00:23:56,170
+بالعربي حمى الضنك تمام مشهورة أنَّها موجودة في السعودية
+
+303
+00:23:56,170 --> 00:24:00,930
+وموجودة في اليمن طبعا في دول جنوب شرق آسيا أمر
+
+304
+00:24:00,930 --> 00:24:06,010
+طبيعي أن يكون فيهم دنجي فيروس الـ yellow و الـ dingy
+
+305
+00:24:06,010 --> 00:24:09,050
+و الـ west nile virus تلتها بينتقل عبر البعوض
+
+306
+00:24:11,330 --> 00:24:17,430
+وخلينا نتكلم عن البعوض كنقل للأمراض الفيروسية طبعا
+
+307
+00:24:17,430 --> 00:24:21,190
+بتعرفوا أن البعوض أنواع مش نوع واحد أنواع وسلالات
+
+308
+00:24:21,190 --> 00:24:28,330
+كثيرة ومتنوعة منها ما ينقل أمراض مخصصة ومنها لا
+
+309
+00:24:28,330 --> 00:24:34,190
+يعيش إلا في مناطق مخصصة بمعنى الملاريا احنا لدينا
+
+310
+00:24:34,190 --> 00:24:38,390
+ملاريا فقط في فلسطين ما عندناش ملاريا ليش ما عندناش
+
+311
+00:24:38,390 --> 00:24:46,270
+ملاريا؟ ما عندناش اللي هو البعوض الناقل للملاريا اللي
+
+312
+00:24:46,270 --> 00:24:49,610
+أنا بدأ أوصله لرسالة بس لوصلها تعرفوا زيكا فيروس
+
+313
+00:24:49,610 --> 00:24:53,310
+سمعتوا في زيكا فيروس السنة الماضية أو اللي جابلها
+
+314
+00:24:53,310 --> 00:24:56,790
+كان هو نجم الأخبار واحنا عملنا عنه محاضرات في
+
+315
+00:24:56,790 --> 00:25:00,910
+الجامعة حتى للتعريف بزيكا فيروس اللي كان بسبب
+
+316
+00:25:00,910 --> 00:25:04,010
+الأطفال لأنهم microcephaly رؤوس صغيرة رؤوس بتكون
+
+317
+00:25:04,010 --> 00:25:10,240
+صغيرة هذه الذيكا في منطقة في أفريقيا أعتقد في زئير
+
+318
+00:25:10,240 --> 00:25:16,060
+مش بتأكد الدولة الأفريقية لكن الآن وين المرض؟ في
+
+319
+00:25:16,060 --> 00:25:16,600
+البرازيل
+
+320
+00:25:19,440 --> 00:25:26,640
+اليوم نحن في عصر انتقال البشر والحيوانات والطيور
+
+321
+00:25:26,640 --> 00:25:29,660
+من أول الطيور، هي الوحيدة اللي كانت أصلا تنتقل
+
+322
+00:25:29,660 --> 00:25:34,480
+بسهولة، بعدين صارنا احنا، وبعدين صارت الحيوانات،
+
+323
+00:25:34,480 --> 00:25:37,220
+تمشي معاها الجوردان تطلع بعد جت معاها نفسها،
+
+324
+00:25:37,220 --> 00:25:40,720
+الجوردان انتقلت حول العالم بقى بالسفن بالصفن اللي
+
+325
+00:25:40,720 --> 00:25:44,380
+... اللي كانت تنتقل من مكان إلى مكان الكوليرا اللي
+
+326
+00:25:44,380 --> 00:25:49,120
+هي البكتيريا بقت تنتقل برضه بالصفن من الـ .. من ..
+
+327
+00:25:49,120 --> 00:25:52,480
+من دولة إلى دولة أنتو عارفين أن في أحد السنوات
+
+328
+00:25:52,480 --> 00:25:57,660
+منعت الحج من الهند بقرار هندي .. بقرار هندي لما
+
+329
+00:25:57,660 --> 00:26:02,160
+كان حاكم الهند مسلم .. كان حاكم الهند مسلم لماذا
+
+330
+00:26:02,160 --> 00:26:08,650
+الحجاج الهند .. اللي هون بشكل عام لديهم معتقدات
+
+331
+00:26:08,650 --> 00:26:12,250
+غريبة وعجيبة مثلا عندهم نهر الـ gang هذا نهر الـ
+
+332
+00:26:12,250 --> 00:26:16,430
+gang بيستحموا فيه وبيبرّوا ماء مقدس يعني اللي
+
+333
+00:26:16,430 --> 00:26:20,630
+بيستحمى فيه بطيب طبعا لو تطلع على منظر المياه اللي
+
+334
+00:26:20,630 --> 00:26:25,890
+فيه يعني هو مش .. مش نهر .. يعني نهر نظيف لأ نهر
+
+335
+00:26:25,890 --> 00:26:29,490
+بالفعل قذر وممكن تلاقي فيه أشياء ميتة يعني
+
+336
+00:26:29,490 --> 00:26:30,650
+مصائب
+
+337
+00:26:32,750 --> 00:26:36,990
+فيبدو أن حتى الـ .. الـ .. الـ .. الـ .. الديانات
+
+338
+00:26:36,990 --> 00:26:39,870
+الأخرى اللي غير الهندوسية بتأثر بالثقافات، يعني
+
+339
+00:26:39,870 --> 00:26:45,030
+بتأثروا بعض، فالمهم أن انتشار الكوليرا في الهند كان
+
+340
+00:26:45,030 --> 00:26:49,590
+أمر طبيعي، فطلع مجموعة من الحجاج على مكة في أحد
+
+341
+00:26:49,590 --> 00:26:54,550
+السنوات و ... يعني ... يعني يذكر ... الحاجة تذكر أنَّه
+
+342
+00:26:54,550 --> 00:26:59,350
+من ... من أربعين ألف حاج مغربي لم يعد إلا خمسة ألف
+
+343
+00:26:59,350 --> 00:27:02,990
+أو ستة ألف، رقم بسيط جدا من الحجاج اللي عاد سالمو
+
+344
+00:27:02,990 --> 00:27:07,290
+الباقي توفي في طريقه وهو مروح من الحج، من مرض
+
+345
+00:27:07,290 --> 00:27:14,000
+الكوليرا، الآن الكوليرا هو موجود في كل الدنيا
+
+346
+00:27:14,000 --> 00:27:16,680
+طبعا بيانة على المعلومات هذه اللي حكيتها هنا
+
+347
+00:27:16,680 --> 00:27:20,460
+الحاكم الهندي السنة اللي بعديها منع قولنا الحج
+
+348
+00:27:20,460 --> 00:27:28,540
+لأسباب صحية كانوا يعملوا حجر صحي الأمراض تنتقل
+
+349
+00:27:28,540 --> 00:27:33,340
+وناقلاتها الآن تنتقل وفي عامل جديد دخل على الساحة
+
+350
+00:27:33,340 --> 00:27:36,320
+اللي هو الـ global warming اللي هو اللي بيعمل
+
+351
+00:27:36,320 --> 00:27:41,400
+climate change أو التغيرات المناخية اللي صار فيه
+
+352
+00:27:41,400 --> 00:27:45,000
+prediction من ... من قبل بعض العلماء أن بعض الدول
+
+353
+00:27:45,000 --> 00:27:49,060
+هتغرق، هتختفي تماما زي Bangladesh، تمام؟ وبعض
+
+354
+00:27:49,060 --> 00:27:52,960
+الدول الصحراوية زي السعودية مثلا، هتصبح خضراء،
+
+355
+00:27:52,960 --> 00:27:56,300
+يعني من كثرة الأمطار، يعني حصي في توزيع مختلف
+
+356
+00:27:56,300 --> 00:27:59,600
+للأمطار والمياه وارتفاع درجة الحرارة في الأماكن
+
+357
+00:27:59,600 --> 00:28:03,140
+وانخفاضها في أماكن أخرى من كوكب الأرض، هتسموه
+
+358
+00:28:03,140 --> 00:28:06,870
+التغيرات المناخية طبعا البعض لحد الآن بيظن أن هذا
+
+359
+00:28:06,870 --> 00:28:14,410
+خيال علمي بس الحقيقة أنه بدأنا نلمس نتائجه وبالتالي
+
+360
+00:28:14,410 --> 00:28:19,010
+ناقلات للحشرات اللي لم تكن قادرة على المعيشة في
+
+361
+00:28:19,010 --> 00:28:23,470
+مكان X ستصبح قادرة على هذا الـ ... الـ ... الـ ... أو على
+
+362
+00:28:23,470 --> 00:28:27,710
+هذه المعيشة والتكاثر فيها وبالتالي ما بنداش نقول
+
+363
+00:28:27,710 --> 00:28:31,170
+أن احنا هذا الفيروس ليس موجود عندنا أو هذا الـ ...
+
+364
+00:28:31,170 --> 00:28:35,050
+الـ ... المرض ليس موجود عندنا في المستقبل القريب زي
+
+365
+00:28:35,050 --> 00:28:39,190
+ما الـ internet عمل العالم قرية صغيرة أيضا الـ ... الـ
+
+366
+00:28:39,190 --> 00:28:43,110
+global warming هيعمل العالم قرية صغيرة بس بالنسبة
+
+367
+00:28:43,110 --> 00:28:49,180
+لمين؟ للحشرات والأمراض والقراد الفيروس اللي بيختلف
+
+368
+00:28:49,180 --> 00:28:52,680
+عنهم الصحيح بينتقلش عن طريق الـ ... الـ ... بينتقلش عن
+
+369
+00:28:52,680 --> 00:28:55,440
+طريق اللي هو البعوض اللي هو الـ Hepatitis C وبينتقل
+
+370
+00:28:55,440 --> 00:29:01,720
+عن طريق الدم والـ Hepatitis C ليس له vaccine فعال
+
+371
+00:29:01,720 --> 00:29:07,440
+صحيح جديد لجولة drug كويس very expensive بيسموه
+
+372
+00:29:07,440 --> 00:29:12,390
+Sovaldi وهذا الـ drug يعني ... خلّيني نقول أعطى فرص
+
+373
+00:29:12,390 --> 00:29:17,370
+أمل للشفاء لأنه ناس كثيرة كانت نسبة الأمل عندهم
+
+374
+00:29:17,370 --> 00:29:22,090
+معدومة تقريبا من Hepatitis C أحد مساوئ Hepatitis
+
+375
+00:29:22,090 --> 00:29:25,890
+C أن الـ complication تبع طلبانات بتعمل Cancer فهو
+
+376
+00:29:25,890 --> 00:29:33,990
+من مسببات أيضا ال Cancer  Toga
+
+377
+00:29:33,990 --> 00:29:34,470
+Virus
+
+378
+00:29:37,680 --> 00:29:42,160
+في  تين جروب من التوجه فيروس هما ال alpha virus و
+
+379
+00:29:42,160 --> 00:29:46,580
+ال rubella virus ال alpha virus بيعمل أو بيشمل على
+
+380
+00:29:46,580 --> 00:29:50,420
+فيروسين مهمين eastern and western encephalitis
+
+381
+00:29:50,420 --> 00:29:55,860
+virus واضح انه تسمي eastern و western على الأماكن
+
+382
+00:29:55,860 --> 00:29:59,660
+اللي عزل منها هذا الفيروس لكن المرض هو
+
+383
+00:29:59,660 --> 00:30:02,680
+encephalitis و ال encephalitis هي التهاب الدماغ
+
+384
+00:30:02,680 --> 00:30:06,820
+وهو مرض خطير جدا.الروبي فايروس بالنسبة ان احنا في
+
+385
+00:30:06,820 --> 00:30:12,940
+فلسطين اهم كتير من اللي هو رقم واحد روبي ماخوذ منه
+
+386
+00:30:12,940 --> 00:30:16,140
+كلمة Rubella Rubella اللي هي ال German measles
+
+387
+00:30:16,140 --> 00:30:19,720
+الحصبة الألمانية اللي اتحدثنا عنها المحاضرة
+
+388
+00:30:19,720 --> 00:30:25,880
+السابقة كان لها اسم لذيذ اسم حصبة التلات أيام حصبة
+
+389
+00:30:25,880 --> 00:30:32,790
+التلات أيام ليش حصبة التلات أيام لأنهعنا الطفل
+
+390
+00:30:32,790 --> 00:30:36,350
+اللى بيطلع عليه اللى هو او بيطلع عليه ال .. ال
+
+391
+00:30:36,350 --> 00:30:40,370
+maculopapular rashes ال rashes اللى طفح الجلدى كان
+
+392
+00:30:40,370 --> 00:30:45,130
+بيستمر تقريبا الى تلت أيام فسموها حصبة التلت أيام
+
+393
+00:30:45,130 --> 00:30:49,310
+عشان يميزوها عن مين؟ عن ال measles اللي هى الأخرى
+
+394
+00:30:49,310 --> 00:30:54,910
+اللي كانت تاخد وقت طبعا أطول اسمها اسم المرض
+
+395
+00:30:54,910 --> 00:31:01,260
+German measles و ال .. من ..طرق انتقالها أو طريقة
+
+396
+00:31:01,260 --> 00:31:06,940
+انتقالها غالبا عبر ال respiratory tract وخطرتها
+
+397
+00:31:06,940 --> 00:31:12,360
+اكثر عندما اتحدث عن .. عندما اتحدث عن اللي هو
+
+398
+00:31:12,360 --> 00:31:21,030
+الجنين و الأم الحامل كلما أصيبت المرأة الحاملفي سن
+
+399
+00:31:21,030 --> 00:31:24,790
+أو مش في سن في عمر مبكر من الحمل يعني في الأشهر
+
+400
+00:31:24,790 --> 00:31:30,290
+الأولى بيكون الأمر أخطر من مين؟ من الأشهر المتقدمة
+
+401
+00:31:30,290 --> 00:31:33,210
+يعني في ال first trimester أخطر من ال second
+
+402
+00:31:33,210 --> 00:31:37,630
+trimester أخطر من ال third trimester شوفوا الآن
+
+403
+00:31:37,630 --> 00:31:42,210
+الرقم اللي مذكور عنه على اللوحة هنا عشرين بالمائة
+
+404
+00:31:42,210 --> 00:31:48,270
+فرصة ان الجنين يصير عنده complications أو
+
+405
+00:31:48,270 --> 00:31:54,650
+deformities بتكون عالية هذه الفرصة متى؟ في بداية ال
+
+406
+00:31:54,650 --> 00:31:58,750
+pregnancy، في بداية اللي هو الحمض زي إيش فينا
+
+407
+00:31:58,750 --> 00:32:04,510
+deformities أو complications ممكن تحصلت للجنين؟
+
+408
+00:32:04,510 --> 00:32:10,090
+واحد، deafness، فقدان السماء، cataract، مشكلة في
+
+409
+00:32:10,090 --> 00:32:12,710
+العين، heart defects اللي هي الميهة البيضاء،
+
+410
+00:32:12,710 --> 00:32:17,160
+بيسموها الميهة البيضاء Heart defects خلل فيه عوضة
+
+411
+00:32:17,160 --> 00:32:22,200
+القلب Mental retardation تخلف ذهني أو عقلي and
+
+412
+00:32:22,200 --> 00:32:26,900
+liver and spleen damage إذا في مخاطر كبيرة و قد
+
+413
+00:32:26,900 --> 00:32:31,040
+يصل الأمر يبنيها إلى أنه يصير فيه abortion أو أن
+
+414
+00:32:31,040 --> 00:32:36,340
+الطفل يولد ميتا إذا فينا مخاطر كبيرة من الربلة على
+
+415
+00:32:36,340 --> 00:32:41,400
+الأم الحامل و أنا ذكرت لكم في محاضرة سابقةبإنه فيه
+
+416
+00:32:41,400 --> 00:32:47,920
+تطايم جرعة انشطية للبنات مش للذكور للبنات في سن
+
+417
+00:32:47,920 --> 00:32:51,540
+الزواج اللي هو السن الأددية او من سن بدء الزواج
+
+418
+00:32:51,540 --> 00:32:56,580
+اللي هو السن الأددىطبعا احنا بناخد فاكسين و
+
+419
+00:32:56,580 --> 00:33:01,100
+الفاكسين هذا اسمه MMR و لو طلعتوا على بطاقاتكم
+
+420
+00:33:01,100 --> 00:33:06,760
+التطييم او على خدكم الصغار بتلاقوا ال MMR جزء
+
+421
+00:33:06,760 --> 00:33:10,040
+أساسي من التطييمات اللي بياخدها الأطفال في فلسطين
+
+422
+00:33:10,040 --> 00:33:16,000
+و بيبدأ التطييم من 12 إلى 15 شهر و ليس قبل و هنا
+
+423
+00:33:16,000 --> 00:33:21,100
+لابد ان نقف عند هذا الرقم و لماذا؟ بعضالأمراض
+
+424
+00:33:21,100 --> 00:33:24,140
+بنطعملها من أول يوم و أمراض أخرى بنطعملها بعد أربع
+
+425
+00:33:24,140 --> 00:33:28,080
+شهور و بعد ست شهور، هل هو مزاج يعني و انتقائي ولا
+
+426
+00:33:28,080 --> 00:33:32,040
+في أكيد أسباب؟ في أكيد أسباب، أحد الأسباب اللي هنا
+
+427
+00:33:32,040 --> 00:33:37,600
+إن طالما الـM أصلا مطعمة للـMMR، يبقى المولود
+
+428
+00:33:37,600 --> 00:33:42,860
+هيحتوي في رسمه أو في دمه على IgG، immunoglobulins
+
+429
+00:33:43,900 --> 00:33:49,380
+الان لو انا حاطط الطفل antigen للروبيلا ال
+
+430
+00:33:49,380 --> 00:33:53,740
+antibodies اللى موجودة في رسم الطفل هتتفاعل و تعمل
+
+431
+00:33:53,740 --> 00:33:56,200
+ال neutralization لمن؟ للفيروس
+
+432
+00:33:59,290 --> 00:34:03,290
+مناعة الطفل اللي أخدها من الأم عملت interference
+
+433
+00:34:03,290 --> 00:34:07,810
+مع ال vaccination هدف ال vaccine أن يستثير جهاز
+
+434
+00:34:07,810 --> 00:34:12,170
+المناعة لإنتاج أجسام مضادة لكن للأسف الأجسام
+
+435
+00:34:12,170 --> 00:34:16,190
+المضادة اللي موجودة في رسم الطفل ارتبط لمين فبتالي
+
+436
+00:34:16,190 --> 00:34:21,230
+أجلنا ال vaccine إلى سن بتكون ال antibodies اللي
+
+437
+00:34:21,230 --> 00:34:26,110
+أخدها من الأم قد بدأت تذوي أو تفقد أو تعدم
+
+438
+00:34:26,110 --> 00:34:31,430
+وبالتالي بنعطيه ال vaccine في هذه الفترة.الان كلمة
+
+439
+00:34:31,430 --> 00:34:38,010
+second dose تقطعتها على أربع إلى ستة سنوات وكنا
+
+440
+00:34:38,010 --> 00:34:41,630
+before kindergarten اللي هي الروضة أو الحضانة
+
+441
+00:34:41,630 --> 00:34:46,230
+بيسموها و ال first grade اللي هو الصف الأول الجرعة
+
+442
+00:34:46,230 --> 00:34:49,930
+الثانية في فرق بينها و بين الأولى حوالى تلت سنوات
+
+443
+00:34:49,930 --> 00:34:57,110
+ولا لا إلى أربع سنوات هذا الفرق الكبير مهم جدا
+
+444
+00:34:58,320 --> 00:35:03,260
+الطفل كون أجسام مضادة في الجرعة الأولى وصار عنده
+
+445
+00:35:03,260 --> 00:35:08,500
+immune response بشكل إنتاج antibody و memory cells
+
+446
+00:35:08,500 --> 00:35:15,360
+خلايا ذاكرة لما بنعطيه جرعة منشطة ليها second dose
+
+447
+00:35:15,360 --> 00:35:18,940
+ايش بيسمي الجرعة منشطة باللغة الإنجليزية booster dose
+
+448
+00:35:18,940 --> 00:35:26,380
+booster dose بسميها جرعة منشطة او جرعة دايمة جرعة
+
+449
+00:35:26,380 --> 00:35:32,230
+دايمةالـ Response في الجرعة الدائمة بيكون أقوى
+
+450
+00:35:32,230 --> 00:35:36,790
+بكثير من الجرعة الأولى لإن فيها الناس الأهم memory
+
+451
+00:35:36,790 --> 00:35:42,910
+cells الجهاز المنع مازال يتذكر هذا الفيروس ومازال
+
+452
+00:35:42,910 --> 00:35:47,110
+يتذكر كيف يمكن أن ينتج له أجسام مضادة وبتالي بكل
+
+453
+00:35:47,110 --> 00:35:52,400
+سهولة بينتجله كمية كبيرة.الفيروس الخامس ال retro
+
+454
+00:35:52,400 --> 00:35:55,680
+virus و ال retro pertains to the reverse
+
+455
+00:35:55,680 --> 00:35:58,860
+transcription of the RNA genome to DNA احنا بنعرف
+
+456
+00:35:58,860 --> 00:36:03,640
+انه DNA ل RNA الوضع الطبيعي هذا من RNA إلى DNA two
+
+457
+00:36:03,640 --> 00:36:08,360
+groups حد يسميها lentivirus و حد يسميها onco
+
+458
+00:36:08,360 --> 00:36:13,720
+virus onco يعني مسبب للأورام و ال lenti small زي
+
+459
+00:36:13,720 --> 00:36:19,160
+العدس من lentil lentil معناها عدس امام؟ very small
+
+460
+00:36:19,160 --> 00:36:24,310
+virusesو بينجو سينج كانت بيعنى slow virus slow
+
+461
+00:36:24,310 --> 00:36:27,930
+virus لإنه يمكن سمعته بأن ناس أصيبوا أعلن عن
+
+462
+00:36:27,930 --> 00:36:31,130
+أنفسهم إنهم مصابين من المشاهير من المصابين بال
+
+463
+00:36:31,130 --> 00:36:34,350
+AIDS زي واحد اسمه magic johnson كان لاعب كرة سلة
+
+464
+00:36:34,350 --> 00:36:40,130
+مشهور جدا في العالم أعلن إنه مصاب بال HIV فحص واحد
+
+465
+00:36:40,130 --> 00:36:44,530
+اللي كان عنده HIV لكن رجع يلعب كرة سلة عادي
+
+466
+00:36:44,530 --> 00:36:47,890
+ومابتعرفش إيش طبعا أنا مش بتبين هذا الكلام جاب
+
+467
+00:36:47,890 --> 00:36:52,340
+العشرين سنة يمكن تمام؟فالفيروس بيصنع من ال slow
+
+468
+00:36:52,340 --> 00:36:57,740
+virus من أشهر هذه الفيروسات اللي هو ال HIV virus
+
+469
+00:36:57,740 --> 00:37:01,360
+في فيروسات بتصيب الحيوانات لكن لو بتصيبش الإنسان
+
+470
+00:37:01,360 --> 00:37:06,540
+من نفس الفصيلة اسمها Vesna virus ال oncoviruses في
+
+471
+00:37:06,540 --> 00:37:10,920
+مثال عليها مشهور جدا بتصيب الإنسان اللي هو human T
+
+472
+00:37:10,920 --> 00:37:17,140
+cell leukemia virus HTLV human T cell leukemia
+
+473
+00:37:17,140 --> 00:37:22,650
+virus.الارثوميكس فيروس حاكينا عنها هنا هي اللي ..
+
+474
+00:37:22,650 --> 00:37:25,310
+اللي بتاعة ال influenza وانا دايما بقول ال
+
+475
+00:37:25,310 --> 00:37:28,110
+influenza فيروس واحدة من أهم الفيروسات على كوكب
+
+476
+00:37:28,110 --> 00:37:32,370
+الأرض اللي كل سبع إلى عشر سنوات بتفاجئنا بسلولة
+
+477
+00:37:32,370 --> 00:37:35,790
+جديدة بطلنا .. بطلنا .. بطلنا نتفاجأ من أننا
+
+478
+00:37:35,790 --> 00:37:38,710
+مابنعرفش بجهة بطلنا نتفاجأ من هذه السلولات الجديدة
+
+479
+00:37:40,220 --> 00:37:45,660
+الـ Paramyxovirus بتشمل مجموعة مهمة جدا من
+
+480
+00:37:45,660 --> 00:37:50,120
+الفيروسات زي الميسلز والمامبس والميسلز بنات زي ما
+
+481
+00:37:50,120 --> 00:37:54,380
+ذكرتلكوا كانت في السابق يعني نسبة الوفيات فيها قد
+
+482
+00:37:54,380 --> 00:37:59,040
+تصل إلى خمسين بالمائة قبل ال vaccination، المامبس
+
+483
+00:38:00,280 --> 00:38:03,560
+للأسف كانت فعلا عدد سيء عندنا الصغار لما كان الطفل
+
+484
+00:38:03,560 --> 00:38:06,960
+يصاب بال mumps تمام؟ طبعا نسبة كبيرة من الأطفال
+
+485
+00:38:06,960 --> 00:38:10,620
+كانوا يصاب بال mumps كانوا يخدهم على حد يدعى شيخ
+
+486
+00:38:10,620 --> 00:38:14,420
+هو مش شيخ يكتبله آية الكورسي على خده تمام؟ يعني
+
+487
+00:38:14,420 --> 00:38:19,140
+استشفاء بالقرآن وهذا كان بينم عن مين؟ عن جهل مدقق
+
+488
+00:38:19,140 --> 00:38:21,940
+لأن الطفل كان يروح الحمام ويطلع من الحمام وهو
+
+489
+00:38:21,940 --> 00:38:26,500
+مكتوب عليه هذه الكلمة للأسف هذه كانت موجودة بكثرة
+
+490
+00:38:26,500 --> 00:38:31,230
+لأن بالفعل الناس جهل وانا دايما بقول جهلالعلماء
+
+491
+00:38:31,230 --> 00:38:35,330
+وجهل المثقفين أسوأ مليون مرة من جهل مين؟ من جهل
+
+492
+00:38:35,330 --> 00:38:40,190
+العامة لأن العالم الجاهل يعني هو كيف يكون عالم
+
+493
+00:38:40,190 --> 00:38:47,330
+جاهل في نفس الوقت مش ذاك هو ده لا بس موجود زي اللي
+
+494
+00:38:47,330 --> 00:38:50,830
+احنا حكينا عنه قبل قليل عامل حاله انه شيخ لكن هو
+
+495
+00:38:50,830 --> 00:38:56,590
+يجهل ان هذا الكلام اللي بيعمله غير جائز شرعا.ميسلز
+
+496
+00:38:56,590 --> 00:38:59,770
+مامس من الأمراض الخطيرة ضفنا عليهم الربلا صار
+
+497
+00:38:59,770 --> 00:39:05,110
+علينا MMR ميسلز مامس and ربلا ايضا ال para
+
+498
+00:39:05,110 --> 00:39:07,750
+influenza واضح من كلمة para influenza انها بتعمل
+
+499
+00:39:07,750 --> 00:39:11,490
+disease بيشبه ال influenza و الرعب اللي هو ال
+
+500
+00:39:11,490 --> 00:39:14,330
+respiratory syncytial الفيروس اللي قلنالكوا هو
+
+501
+00:39:14,330 --> 00:39:18,430
+بيعمل syncytia طبعا هذه الصورة على طفل عنده منتفخ
+
+502
+00:39:18,430 --> 00:39:23,610
+الأوداج لأن الـ مَمْسَ بَيصِيب اللي هو الغدة النكافية
+
+503
+00:39:23,610 --> 00:39:28,210
+اللي بيسموها Paratoid، It's a salivary gland هذه
+
+504
+00:39:28,210 --> 00:39:35,930
+الصورة بتوضح الرشد على رسم طفل على رسم طفل مصاب
+
+505
+00:39:35,930 --> 00:39:39,550
+بالحصبة تشبه الـ German measles اللي شفناها لكن
+
+506
+00:39:39,550 --> 00:39:44,070
+ميزنا بيها نقول لكوا في الفترة الزمنية الـ Rhabdovirus
+
+507
+00:39:44,070 --> 00:39:49,050
+هو الفيروس اللي بيشبه الـ bullet أو الرصاصة وبينتمي
+
+508
+00:39:49,050 --> 00:39:53,230
+لـ rabies virus وهو الوحيد اللي important human
+
+509
+00:39:53,230 --> 00:39:55,950
+pathogen ويمكن تحدثت عنه المرة الماضية وقلت لكوا
+
+510
+00:39:55,950 --> 00:39:59,670
+أنه صار فيه change بالظبط صار فيه change في الـ
+
+511
+00:39:59,670 --> 00:40:03,290
+epidemiology لهذا الـ .. الـ .. الـ virus من خلال
+
+512
+00:40:03,290 --> 00:40:07,230
+الانتقال كان ينتقل عن طريق الكلاب وبعض الحيوانات
+
+513
+00:40:07,230 --> 00:40:10,750
+أظن، لكن الآن بينتقل أكثر شيء عن طريق الخفافيش
+
+514
+00:40:11,050 --> 00:40:15,870
+الصورة اللي تحتها بتبين لي تمّ، تمّ يعني معناها
+
+515
+00:40:15,870 --> 00:40:19,610
+transmission electron microscope وفيه SEM اللي هي
+
+516
+00:40:19,610 --> 00:40:22,450
+scanning electron microscope فدول تمّ، تمّ مشهورين
+
+517
+00:40:22,450 --> 00:40:25,530
+SEM وتمّ لازم تكونوا عارفينهم، تمّ معناها
+
+518
+00:40:25,530 --> 00:40:29,350
+transmission والـ SEM يعني Scanning بيعطينا صورة
+
+519
+00:40:29,350 --> 00:40:35,030
+من الخارج والـ transmission يعطينا صورة من الداخل هنا
+
+520
+00:40:35,030 --> 00:40:42,230
+في نسيج ومليء بالـ bullet shape virus particle من
+
+521
+00:40:42,230 --> 00:40:48,310
+الـ rabies virus الفيروس فيه اللي قلنا أنا
+
+522
+00:40:48,310 --> 00:40:51,470
+هخيطيه، وأخذنا عليه مثالين اللي هم مين؟ Ebola and
+
+523
+00:40:51,470 --> 00:40:56,990
+Marburg وHighly Pleomorphic أول مرة يمرّ معنا
+
+524
+00:40:56,990 --> 00:41:00,630
+مصطلح Pleomorphic في الفيروسات كان يمرّ معنا وين؟
+
+525
+00:41:00,630 --> 00:41:05,330
+في البكتيريا، البكتيريا لما تكون تمتلك أشكال أو
+
+526
+00:41:05,330 --> 00:41:09,370
+تُعطيها القدرة على إنها تغير شكلها مرارًا وتكرارًا
+
+527
+00:41:09,370 --> 00:41:13,550
+تمام، أو حاجاتها مختلفة نسميها pleomorphic طبعًا
+
+528
+00:41:13,550 --> 00:41:19,540
+لأن خيطي أكيد ممكن ينحني بأشكال مختلفة، الـ
+
+529
+00:41:19,540 --> 00:41:23,880
+Coronavirus أظن حلو للفيروس هذا، جميل الصورة تبعته
+
+530
+00:41:23,880 --> 00:41:27,900
+ومن هنا أُطلق عليه Corona لأن الـ Glycoprotein
+
+531
+00:41:27,900 --> 00:41:33,360
+تبعته مصفوفة بشكل تاج فسموها Coronavirus، طبعًا الـ
+
+532
+00:41:33,360 --> 00:41:38,860
+Coronavirus من أشهر الأمراض بيننا الـ SARS والـ
+
+533
+00:41:38,860 --> 00:41:44,840
+MERS-CoV في السعودية وأيضًا بتسبب لنا الرشح، الـ Arena
+
+534
+00:41:44,840 --> 00:41:49,420
+Virus طلع الفيروس هنا جواه هتلاقوا اللي هو مين؟ الـ
+
+535
+00:41:49,420 --> 00:41:51,780
+ribosomes اللي احنا حكينا عنهم اللي سميناهم non-
+
+536
+00:41:51,780 --> 00:41:55,880
+functional ribosomes من أشهر الـ pathogens اللي
+
+537
+00:41:55,880 --> 00:41:58,420
+مولودة في هذه السلسلة الـ Lymphocytic
+
+538
+00:41:58,420 --> 00:42:03,340
+choriomeningitis virus أو LCV واللاّسا fever وكلاهما
+
+539
+00:42:03,340 --> 00:42:06,280
+من الفيروسات، من الفيروسات أيضًا الخطيرة
+
+540
+00:42:06,280 --> 00:42:10,760
+الـ Bunyavirus أيضًا من الفيروسات الخطيرة وعليه أمثلة
+
+541
+00:42:10,760 --> 00:42:16,120
+اللي هم الـ Korean hemorrhagic fever حمى الكورية
+
+542
+00:42:16,120 --> 00:42:21,700
+النزفية والهانتا فيروس والسين نومبري فيروس، الثلاثة
+
+543
+00:42:21,700 --> 00:42:26,380
+أسماءهم عندما تُذكر في عالم الفيروسات تُثير القشعريرة
+
+544
+00:42:26,380 --> 00:42:32,460
+زي إيبولا وزي ماربورج فيروس، أي فيروس بيعمل حمى
+
+545
+00:42:32,460 --> 00:42:37,840
+نزفية معناه الحق إنه هذا ممكن يُدَمِّر organs في الجسم
+
+546
+00:42:37,840 --> 00:42:43,450
+ويمكن يُدَمِّر الجسم بشكل كبير، الأخير في السلسلة وهو
+
+547
+00:42:43,450 --> 00:42:46,830
+الشهير جدًا، صعب بالنسبة إلى إنه هو الـ Delta Virus
+
+548
+00:42:46,830 --> 00:42:53,210
+وشهرته ناتجة من إنه هو defective virus ولا يمكن أن
+
+549
+00:42:53,210 --> 00:42:58,290
+يُصيب الإنسان إلا إذا كان ب موجود، ففي B ممكن
+
+550
+00:42:58,290 --> 00:43:06,710
+التلاني يدخلوا مع بعض أو ممكن يجي D لاحقًا، بيسموه
+
+551
+00:43:06,710 --> 00:43:11,950
+D on top of B، D on top يعني إنه جاي بعد اللي هو
+
+552
+00:43:11,950 --> 00:43:15,630
+الـ B أو إنه يكونوا الاثنين جايين مع بعض، وعلى فكرة
+
+553
+00:43:15,630 --> 00:43:18,410
+الـ outcome تبقى الـ infection بيختلف إذا كانوا
+
+554
+00:43:18,410 --> 00:43:22,630
+اثنين مع بعض جايين غير لما بيكونوا واحد وراء
+
+555
+00:43:22,630 --> 00:43:27,760
+الثاني، أبنك على، ممكن تقريبًا أنهينا اللي هو الـ
+
+556
+00:43:27,760 --> 00:43:30,660
+classification of medically important viruses وأنا
+
+557
+00:43:30,660 --> 00:43:34,800
+يعني بدأت أحكي كلّ انتين، في ختام الفصل إن هذا الـ
+
+558
+00:43:34,800 --> 00:43:39,320
+chapter بالذات يحتاج منّا جهودًا كبيرة، من أي ناحية،
+
+559
+00:43:39,320 --> 00:43:43,260
+هو أسماء كثيرة، صفات كثيرة، وكونه classification
+
+560
+00:43:43,260 --> 00:43:47,090
+أكيد لازم يكون فيه معلومات، الشيء المطمئن في الموضوع
+
+561
+00:43:47,090 --> 00:43:53,050
+أنه احنا تقريبًا هندرس هذه الفيروسات بتفاصيل أكثر
+
+562
+00:43:53,050 --> 00:43:58,270
+من ذلك، لكن كويس إنه نوصل للتفاصيل واحنا معانا اللي
+
+563
+00:43:58,270 --> 00:44:02,170
+هو إيه؟ معانا المعلومات الأساسية والرئيسية عن هذه
+
+564
+00:44:02,170 --> 00:44:05,870
+الفيروسات ونتمنى لكم التوفيق إن شاء الله ونكمل
+
+565
+00:44:05,870 --> 00:44:06,470
+المرة القادمة
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/A3bS_ezaB7Y_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/A3bS_ezaB7Y_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..13f51b9e878f7d9321d2c512036b178de4a0536d
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/A3bS_ezaB7Y_raw.srt
@@ -0,0 +1,2260 @@
+1
+00:00:20,990 --> 00:00:24,770
+بسم الله الرحمن الرحيم ما زلنا في الفصل المعنون
+
+2
+00:00:24,770 --> 00:00:28,050
+بـClassification of Medically Important Viruses
+
+3
+00:00:28,050 --> 00:00:32,270
+وعشان تكتمل الصورة لابد من مراجعة سريعة لهذا الفصل
+
+4
+00:00:32,270 --> 00:00:35,450
+بما يعني بدأناه المرة الماضية احنا قولنا ان
+
+5
+00:00:35,450 --> 00:00:39,950
+التصنيف فيه معتمد على حاجتين رئيسيتين وهي المادة
+
+6
+00:00:39,950 --> 00:00:43,910
+الوراثية و ال capsid و ال capsid تكلمنا عن عناصر
+
+7
+00:00:43,910 --> 00:00:47,270
+داخلها جودنا مثلا ال size و ال symmetry ووجود او
+
+8
+00:00:47,270 --> 00:00:51,820
+عدم وجود اللي هو ال envelopeو بعدين بالحديث عن ال
+
+9
+00:00:51,820 --> 00:00:56,460
+classification بناء على المادة الوراثية المصنعة من
+
+10
+00:00:56,460 --> 00:01:01,400
+ال DNA و قلتنا انه ستة مجموعات مهمة درسناها بشيء
+
+11
+00:01:01,400 --> 00:01:05,840
+من الاختصار و بشيء من التفصيل أيضا لا يرتقي الى
+
+12
+00:01:05,840 --> 00:01:10,900
+التفصيل المراد لكن هي مقدمة كما ذكرنا و ليس تفصيل
+
+13
+00:01:10,900 --> 00:01:14,980
+كلان معنى ال barvo virus, papuva viruses و ال
+
+14
+00:01:14,980 --> 00:01:18,820
+adenoviruses الhibabna viruses و ال box viruses
+
+15
+00:01:19,690 --> 00:01:24,330
+وقلنا من أجمل الأشياء في التصنيف هو حفظ
+
+16
+00:01:24,330 --> 00:01:29,650
+الاستثناءات يعني الاستثناء العموميات سهلة لكن بلال
+
+17
+00:01:29,650 --> 00:01:33,050
+الموضوع الاستثناءات هي اللي بتساعد مثل ال box
+
+18
+00:01:33,050 --> 00:01:36,810
+virus لجينا انه استثنائي بانه complex استثنائي
+
+19
+00:01:36,810 --> 00:01:43,010
+بانه بيتكاثر في ال cytoplasm مش في النوك وايضا
+
+20
+00:01:43,010 --> 00:01:46,550
+طرقنا إلى تصنيف من خلال ال diagram وعرفنا بالفعل
+
+21
+00:01:46,550 --> 00:01:50,880
+انه we can classifyDNA virus is based on the
+
+22
+00:01:50,880 --> 00:01:55,840
+presence of or absence of envelope زي مثلا ال ..
+
+23
+00:01:55,840 --> 00:01:59,880
+ال .. ال herpes virus و الhibadna virus و ال .. ال
+
+24
+00:01:59,880 --> 00:02:02,880
+.. ال box viruses كانت كلها enveloped و الباقيين
+
+25
+00:02:02,880 --> 00:02:07,480
+كانوا naked virus و اترقنا للفيروسات بشكل سريع
+
+26
+00:02:07,480 --> 00:02:12,480
+الbarbovirus عرفنا فيه نوعين defective و noneوالـ
+
+27
+00:02:12,480 --> 00:02:17,240
+Non-defective تحدثنا عن الـ B19 فيروس اللي بيعمل
+
+28
+00:02:17,240 --> 00:02:22,280
+Slab Chick Syndrome إذا بتذكره وسمينا اسم تاني
+
+29
+00:02:22,280 --> 00:02:26,260
+بقولنا ال fifth disease أو المرض الخامس البابوفا
+
+30
+00:02:26,260 --> 00:02:30,740
+فيروس علفنا انه مختصر من كلمة papilloma, polioma
+
+31
+00:02:30,740 --> 00:02:34,300
+وsemi-invacuating virus والتلاتة بيقولنا عنهم
+
+32
+00:02:34,300 --> 00:02:37,500
+بيعملوا tumors اتنين بيعملوا tumors في الحيوانات
+
+33
+00:02:37,500 --> 00:02:40,660
+واحد بيعمل tumor في الإنسان اللي هو ال papilloma
+
+34
+00:02:40,660 --> 00:02:45,400
+virusأيضا طرحنا لفيروس اسمه adenovirus والـ
+
+35
+00:02:45,400 --> 00:02:49,260
+adenovirus كان من الفيروسات الشهيرة خاصة في
+
+36
+00:02:49,260 --> 00:02:53,260
+الطفولة لأنه بيعمل الـ pharyngitis وهو very common
+
+37
+00:02:53,260 --> 00:02:59,470
+in childrenالهيبادنة viruses أخدنا مثال واحد عليها
+
+38
+00:02:59,470 --> 00:03:03,250
+اللي هو الهيباطيتس B virus واتكلمنا عن ال
+
+39
+00:03:03,250 --> 00:03:07,870
+uniqueness التفرد تبع هذا ال virus من حيث التركيب
+
+40
+00:03:07,870 --> 00:03:11,530
+قلنا إنه عبارة عن circle لكن هذا ال circle مش
+
+41
+00:03:11,530 --> 00:03:15,890
+complete لا complete في إنه البداية ترتبط مع
+
+42
+00:03:15,890 --> 00:03:20,170
+النهاية ولا complete بإنه double strand مكتمل ال
+
+43
+00:03:20,170 --> 00:03:22,530
+.. ال .. ال .. ال strand ال .. ال complementary
+
+44
+00:03:22,530 --> 00:03:30,010
+للأصليبالظبط لا يتعدى لـ 25% من حجم الـ genome الـ
+
+45
+00:03:30,010 --> 00:03:33,350
+Herpes virus family اتفقنا انها مجموعة كبيرة ايضا
+
+46
+00:03:33,350 --> 00:03:37,190
+وهذه المجموعة تحتوي على عناصر مهمة من الـ
+
+47
+00:03:37,190 --> 00:03:39,510
+medically important viruses زي الـ Herpes simplex
+
+48
+00:03:39,510 --> 00:03:43,310
+type 1, type 2, Varicella zoster, الـ
+
+49
+00:03:43,310 --> 00:03:47,010
+cytomegalovirus و الابشتين بار virus و أفرادنا لها
+
+50
+00:03:47,010 --> 00:03:52,390
+لوحة خاصة بتمتلك بعض الخصائص اللي هي مثلا ال
+
+51
+00:03:52,390 --> 00:03:58,480
+latencyما تحدثنا عن لتنسي الا لهذه المجموعة
+
+52
+00:03:58,480 --> 00:04:01,080
+واتكلمنا عن مرض من اللي بتسببها اللي هو ال
+
+53
+00:04:01,080 --> 00:04:04,500
+infectious mononucleosis وادكرنا ان هذا مرض خطير
+
+54
+00:04:04,500 --> 00:04:08,520
+بسبب ال Epstein-Barr virus الأخير في السلسلة كان
+
+55
+00:04:08,520 --> 00:04:14,810
+اللي هو ال box virusesو ال box virus استحدثنا ايضا
+
+56
+00:04:14,810 --> 00:04:19,170
+عن انتهاءها من كوكب الأرض بالأحرى ال small box
+
+57
+00:04:19,170 --> 00:04:24,770
+virus بوسط أخوه اللي هو ال vaccine اللي كان بالفعل
+
+58
+00:04:24,770 --> 00:04:28,870
+انطلاقة لعلم اللي هو ال vaccination او التطييب
+
+59
+00:04:28,870 --> 00:04:34,950
+اللي ساهم بشكل كبير جدا في خفض عدد الوفيات من
+
+60
+00:04:34,950 --> 00:04:38,810
+الأمراض الماضية بدا اعطيكوا بس مدام ذكرنا هذا
+
+61
+00:04:38,810 --> 00:04:44,840
+المعلومة اعطيكوا معلومة مهمةقبل 100 عام من هذا
+
+62
+00:04:44,840 --> 00:04:52,600
+التاريخ لو حاولنا قراءة نسب الوفيات للأمراض
+
+63
+00:04:52,600 --> 00:04:58,300
+المختلفة من خلال ال bio chart الكعكة تمام؟ هلاج أن
+
+64
+00:04:58,300 --> 00:05:03,740
+53% من نسب الوفيات كانت لصالح من الأمراض الماضية،
+
+65
+00:05:03,740 --> 00:05:06,780
+لما أقول أمراض معضية يعني فيروسات، بكتيريا،
+
+66
+00:05:06,780 --> 00:05:10,680
+فطريات، تفاليات، إلى آخرينعارفين جدش اليوم بتشكل
+
+67
+00:05:10,680 --> 00:05:15,300
+من الكعك العالمي اللي هو فيها فقط تلاتة بالمائة،
+
+68
+00:05:15,300 --> 00:05:19,340
+من تلاتة و خمسين بالمائة انخرط إلى تلاتة بالمائة،
+
+69
+00:05:19,340 --> 00:05:23,420
+هذا بفضل الله سبحانه وتعالى أولا و آخرا، ثم بفضل
+
+70
+00:05:23,420 --> 00:05:27,540
+حشتين رئيسيتانالـ Vaccination اللي هو التطايم اللي
+
+71
+00:05:27,540 --> 00:05:32,380
+هنتكلم عنه و استخدام ال antibiotics طبعا فيه كمان
+
+72
+00:05:32,380 --> 00:05:37,460
+سبب تالت يعني لا يقل أهمية لكن لا يذكر لإنه هو كان
+
+73
+00:05:37,460 --> 00:05:42,020
+تقدم عام للبشر كلهم اللي هي النظافة العامة النظافة
+
+74
+00:05:42,020 --> 00:05:46,960
+العامة إذن ال vaccination كانت من المساهمين الكبار
+
+75
+00:05:46,960 --> 00:05:50,360
+في مين في إقلال نسبة نسبة الوفيات من الأمراض
+
+76
+00:05:50,360 --> 00:05:56,430
+المعلنةثم انتقلنا إلى ال RNA viruses وانتقلنا لل
+
+77
+00:05:56,430 --> 00:06:00,870
+RNA viruses واضحتنا بشكل لا لبس فيه بأن ال RNA
+
+78
+00:06:00,870 --> 00:06:07,250
+viruses أكثر عددا من ال DNA virus وزي ما هناك كان
+
+79
+00:06:07,250 --> 00:06:11,510
+في استثناء بأنه single stranded DNA هنا فيه
+
+80
+00:06:11,510 --> 00:06:16,850
+استثناء double stranded DNA لصالح مين ال Rio virus
+
+81
+00:06:16,850 --> 00:06:23,320
+هنالكن التصنيف معقدة و احنا لجأنا للجداول
+
+82
+00:06:23,320 --> 00:06:27,440
+و حمور على الجداول بشكل برضه سريع عشان نستكمل
+
+83
+00:06:27,440 --> 00:06:32,520
+إجراءاتنا كنا بكورونا فيروس و صمينا بيكو small RNA
+
+84
+00:06:32,520 --> 00:06:37,060
+فيروس و عليه مثال ال poly و ال رينو و ال hepatitis
+
+85
+00:06:37,060 --> 00:06:44,460
+فيروس كاليسي فيروس ريو فيروس و فلافي فيروسالفلافي
+
+86
+00:06:44,460 --> 00:06:47,300
+اللي بتقول عنها الفلافي اللي هي الصفراء الفلافي
+
+87
+00:06:47,300 --> 00:06:50,280
+اللي هي الصفراء والريو اللي احنا اصلا جابه شويه
+
+88
+00:06:50,280 --> 00:06:53,020
+اللي كنا بتكلم عنه هو استثناء وعلى فكرة استثنائته
+
+89
+00:06:53,020 --> 00:07:00,700
+كثيرة وهنشوف لما نطلع على الفقر الخاص بالريو فيروس
+
+90
+00:07:00,700 --> 00:07:03,660
+انه الفئة الاستثنائي فيه أمور كثيرة
+
+91
+00:07:22,660 --> 00:07:24,060
+والالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالال
+
+92
+00:07:27,140 --> 00:07:30,260
+أصلا هو مش .. مش .. مش نوع واحد وحنشوف انه .. انه
+
+93
+00:07:30,260 --> 00:07:34,760
+بينتمي اليهم مجموعات من الفيروسات مهمة جدا مثلا
+
+94
+00:07:34,760 --> 00:07:39,220
+الارثمايكسفيروس اللي باطنع بيه بال influenza virus
+
+95
+00:07:39,220 --> 00:07:42,800
+ممتاز ال influenza virus انا ممكن بعرف اذا كنت
+
+96
+00:07:42,800 --> 00:07:45,680
+المرة الماضية ولا قولتلكوا انه ال influenza virus
+
+97
+00:07:45,680 --> 00:07:50,760
+من الفيروسات القاتلة والتي تاريخيا سجرت حالات قتل
+
+98
+00:07:50,760 --> 00:07:54,820
+عديدة انتوا بتعرفوا ان نسبة الوفيات من ال .. من ال
+
+99
+00:07:54,820 --> 00:08:00,910
+influenza العاديةحوالي نص بالمائة وقد تصل إلى خمسة
+
+100
+00:08:00,910 --> 00:08:05,470
+بالمائة، من نص إلى خمسة بالمائة وأن عدد الوفيات من
+
+101
+00:08:05,470 --> 00:08:09,750
+ال influenza الإسبانية حوالي اربعين مليون وحالة
+
+102
+00:08:09,750 --> 00:08:12,870
+وفاة في سنة الف وتسعمائة واربعتاش وهذا العدد في
+
+103
+00:08:12,870 --> 00:08:18,000
+حينه .. في حينهكان أكبر من عد تعداد من قُتل في
+
+104
+00:08:18,000 --> 00:08:21,060
+الحرب العالمية الأولى والثانية والحرب الأمريكية
+
+105
+00:08:21,060 --> 00:08:25,660
+الفيتنانية، إذا الإنفلوانزا مرض خطير و بفاجئنا كل
+
+106
+00:08:25,660 --> 00:08:29,700
+فترة وفترة بسلولات شرسة بالفعل تحدث وفيات، كان
+
+107
+00:08:29,700 --> 00:08:35,400
+أخرها إنفلوانزا الطيور وإنفلوانزا الخنازيرالرابدو
+
+108
+00:08:35,400 --> 00:08:38,460
+فيروس وهي الفيروسات اللى ذكرنا عنها المرة الماضية
+
+109
+00:08:38,460 --> 00:08:43,940
+بتسبب قولنا ده الكلب وسميت رابدو من الشكل تبع
+
+110
+00:08:43,940 --> 00:08:46,520
+الفيروس اللى هو عامل زى الرصاصة أو ال bullet
+
+111
+00:08:46,520 --> 00:08:51,920
+الفيلو فيروس من شكله الخيطي و الخيطي لأنه انا
+
+112
+00:08:51,920 --> 00:08:56,260
+اذكركوا مرة اخرى انه رأينا هذا الشكل في مقدمة ال
+
+113
+00:08:56,260 --> 00:08:58,620
+biology لما طلعنا على أشكال الفيروسات لجينا فيروس
+
+114
+00:08:58,620 --> 00:09:02,460
+عامل زى الدودةالورم اللي هو ال Ebola Virus طبعا
+
+115
+00:09:02,460 --> 00:09:05,640
+فيه الواخو تاني اسمه Marburg Virus برضه نزل على
+
+116
+00:09:05,640 --> 00:09:12,180
+الصحة الطبية ال Coronavirus ال Arena Virus طبعا ال
+
+117
+00:09:12,180 --> 00:09:16,380
+Corona و هناك السعودية الآن بلفلف فيها فيروس اسمه
+
+118
+00:09:16,380 --> 00:09:20,520
+Merskov Virus Merskov Middle East Respiratory
+
+119
+00:09:20,520 --> 00:09:26,100
+Virus او و Co جاء من كلمة Corona و Corona اشتهت
+
+120
+00:09:26,100 --> 00:09:31,790
+بشغلتين بالرشحالعادى اللى هو ال common cold يبقى
+
+121
+00:09:31,790 --> 00:09:36,670
+ال common cold مرض لا يسببه فيروس واحد اكثر من
+
+122
+00:09:36,670 --> 00:09:41,910
+فيروس هذه نقطة كتير مهمة مثلا ال rhinovirus ال
+
+123
+00:09:41,910 --> 00:09:46,150
+rhinovirus هو المسبب الأساسى للرشح لكن المسبب آخر
+
+124
+00:09:46,150 --> 00:09:52,030
+هو ال coronavirusفيه هنا ال .. ال .. ال SARS و ال
+
+125
+00:09:52,030 --> 00:09:56,230
+SARS من ال .. ال .. ال coronavirus اللي بالفعل
+
+126
+00:09:56,230 --> 00:10:00,150
+اكتسبت publicity عالية في السنوات الأخيرة عندما
+
+127
+00:10:00,150 --> 00:10:04,550
+انتشر في Hong Kong و ارتبط بنا ببعض أنواع من القطر
+
+128
+00:10:04,880 --> 00:10:07,700
+الارينا فيروس اشتهر لدينا الان احنا في ال
+
+129
+00:10:07,700 --> 00:10:10,880
+microbiology هنا او في ال virology اشتهر لدينا
+
+130
+00:10:10,880 --> 00:10:15,980
+بانه بيحتوي على ريبوزومز هو الوحيد و كلمة ارينا
+
+131
+00:10:15,980 --> 00:10:19,960
+قلنالكم انه رمل رمل يعني في الحلبة و الريبوزوم
+
+132
+00:10:19,960 --> 00:10:24,980
+عاملة زي ال sand في هذا الفيروس البنيا فيروس من
+
+133
+00:10:24,980 --> 00:10:31,120
+اخطر الفيروسات ايضا California encephalitis virus
+
+134
+00:10:31,120 --> 00:10:34,750
+اللي انا بقول encephalitis يعني التهاب الدماءفيه
+
+135
+00:10:34,750 --> 00:10:37,250
+كمان هانتا فيروس ايضا من الفيروسات الخطيرة
+
+136
+00:10:37,250 --> 00:10:41,290
+الميكروب الأخير في السلسلة اللي عندنا اللي هو الـ
+
+137
+00:10:41,290 --> 00:10:46,470
+Delta virus وبرضه هذا الفيروس أصبح شهير لديكم صح؟
+
+138
+00:10:46,470 --> 00:10:50,170
+اللي هو الـ defective او الـD الهيبوتايتس D اللي
+
+139
+00:10:50,170 --> 00:10:53,810
+كنا لازمه بيه عشان يقدر يعمل replication أو
+
+140
+00:10:53,810 --> 00:10:58,610
+infection للإنسان الان نعود إلى تفاصيل الفيروسات
+
+141
+00:10:58,610 --> 00:11:01,450
+كلهم يعني بتفاصيلته أيضا برضه قليلة
+
+142
+00:11:05,380 --> 00:11:09,780
+نبدأ بال بي كورنا viruses they are the smallest of
+
+143
+00:11:09,780 --> 00:11:14,800
+مش of all viruses of RNA viruses قدش تقريبا القطر
+
+144
+00:11:14,800 --> 00:11:21,460
+تبعها تمانية و عشرين single-stranded linear non
+
+145
+00:11:21,460 --> 00:11:25,480
+-segmented positive polarity RNA و طبعا فاهمين إيش
+
+146
+00:11:25,480 --> 00:11:31,220
+يعني positive polarity can act as an mRNA مباشرة
+
+147
+00:11:31,220 --> 00:11:36,900
+بدون أي .. يعني بدون أي complementationأنا اكيد
+
+148
+00:11:36,900 --> 00:11:40,820
+ايكوزاهيدرال كابسيل، انا عندي بالمناسبة برنامج
+
+149
+00:11:40,820 --> 00:11:44,280
+عملته انا وطلبة من كلية الطب برنامج محوثب
+
+150
+00:11:44,280 --> 00:11:49,250
+للفيرولوجيعملته يعني على نسخة قديمة من ال ويندوز
+
+151
+00:11:49,250 --> 00:11:51,770
+مش متأكد انه بيشتر على ال .. على نسخ الحديثة
+
+152
+00:11:51,770 --> 00:11:55,250
+فبتجربه على .. على ويندوز عشر ان شاء الله وإذا كان
+
+153
+00:11:55,250 --> 00:11:58,150
+ما زال يعني بيعمل على هذه ال .. ال .. النسخ
+
+154
+00:11:58,150 --> 00:12:04,430
+الجديدة هنزلكيها هذا برنامج عبارة عن قاعدة بيانات
+
+155
+00:12:04,430 --> 00:12:09,800
+صنفنا الفيروسات عليهكل فيروس بيطلله صفحة، بس صفحة
+
+156
+00:12:09,800 --> 00:12:14,660
+واحدة الفيروس، وانقطعت المعلومات مقطعة وملزقة،
+
+157
+00:12:14,660 --> 00:12:17,880
+يعني يسهل حفظه، ممكن تعمله منه تقارير، يعني يتلخصه
+
+158
+00:12:17,880 --> 00:12:21,700
+ال .. الفيروس، كل فيروس تعمله print out ك PDF،
+
+159
+00:12:21,700 --> 00:12:24,740
+برنامج كتير رائع فيه حينهوارجو انه يكون موجود
+
+160
+00:12:24,740 --> 00:12:28,680
+مازال موجود عندي نسخ منه عشان اتيح حالكوا طبعا
+
+161
+00:12:28,680 --> 00:12:32,800
+اللي خلاني اتذكر البرنامج هو ال confusion اللي
+
+162
+00:12:32,800 --> 00:12:36,420
+ممكن يحصل للطالب في موضوع positive polarity و لا
+
+163
+00:12:36,420 --> 00:12:39,800
+negative polarity double stranded و لا single
+
+164
+00:12:39,800 --> 00:12:44,840
+stranded هذه المعلومات بحاجة الى وسيلة مساعدة لإنه
+
+165
+00:12:44,840 --> 00:12:48,220
+اتساعدنا في حياتنا ان شاء الله gunal copico جاي من
+
+166
+00:12:48,220 --> 00:12:54,450
+كلمة small و RNA اللي هي containing virusتو groups
+
+167
+00:12:54,450 --> 00:12:57,670
+مهمين جدا اللي هم ال انترو فيروس و ال رينو فيروس
+
+168
+00:12:57,670 --> 00:13:01,910
+طبعا ال انترو فيروس مجموعة سميت انترو لأنها بتعمل
+
+169
+00:13:01,910 --> 00:13:05,330
+infection في ال intestinal tract لكن لا يعني
+
+170
+00:13:05,330 --> 00:13:09,210
+بالضرورة أنهم بيشبهوا بعض في المرض مثلا ال polio
+
+171
+00:13:09,210 --> 00:13:13,830
+virus في شعر الأطفال مرض خطير جدا و عمال العالم
+
+172
+00:13:13,830 --> 00:13:19,790
+بيحتفل لكن احتفالته ما اكتملتش لإن في ضال الدولتين
+
+173
+00:13:20,510 --> 00:13:24,910
+ما زال بيسجل فيهم حالات شلال الأطفال وهم Pakistan
+
+174
+00:13:24,910 --> 00:13:30,710
+و أفغانستان طبعا حالات قليلة جدا لكن تمنع العالم
+
+175
+00:13:30,710 --> 00:13:33,870
+من الاحتفال بالقضاء على المرض يعني المرض ما زال
+
+176
+00:13:33,870 --> 00:13:39,230
+موجود فلسطين أعلنت خالية من الشلال الأطفال من عدة
+
+177
+00:13:39,230 --> 00:13:43,510
+سنوات بشكل الأرقام لكن بشكل رسمي اعتقد ان فقط قبل
+
+178
+00:13:43,510 --> 00:13:46,030
+عامين تم إعلانها من قبل مرادمة الصحة العالمية انها
+
+179
+00:13:46,030 --> 00:13:51,130
+خالية من شلال الأطفالطبعا ده بقول أنه هذا فضل من
+
+180
+00:13:51,130 --> 00:13:55,670
+الله سبحانه وتعالى وفضل النساء الفلسطينيات اللي
+
+181
+00:13:55,670 --> 00:13:59,870
+بيهتموا كتير في موضوع ال vaccination لأطفالهم،
+
+182
+00:13:59,870 --> 00:14:03,610
+يعني نسبة ال vaccination coverage تصل إلى مائة
+
+183
+00:14:03,610 --> 00:14:09,530
+بالمائة، يعني مافيش طفل بيحرب من إيه؟ من إتة، يعني
+
+184
+00:14:09,530 --> 00:14:14,380
+ماعرفش هل هو محبة أو انتقام يعني من الأم هذاطيب ال
+
+185
+00:14:14,380 --> 00:14:19,060
+انترو فيروس وجدنا بوليو فيروس وكوكساكي فيروس وإيكو
+
+186
+00:14:19,060 --> 00:14:22,200
+فيروس التنين اللي ذكرته من الأخرانيات هو الإيكو
+
+187
+00:14:22,200 --> 00:14:27,520
+والكوكساكي فيروس are both a cause of meningitis
+
+188
+00:14:27,520 --> 00:14:33,020
+يعني برضه بسببه التهاب السحاب أيضا Hepatitis A
+
+189
+00:14:33,020 --> 00:14:37,200
+ينتمي إلى هذه
+
+190
+00:14:37,200 --> 00:14:42,440
+المجموعة طبعا Hepatitis Aتختلف عن B وعن C، احنا
+
+191
+00:14:42,440 --> 00:14:44,680
+قلنا لكوا في مجموعة كبيرة من الـ Hepatitis وقلنا
+
+192
+00:14:44,680 --> 00:14:50,060
+لكوا لا يربطها علاقة إلى ال target اللي هم في
+
+193
+00:14:50,060 --> 00:14:52,940
+الآخر بيعملوه أو ال disease اللي هو التهيأة ال
+
+194
+00:14:52,940 --> 00:14:58,200
+inflammation of the liver فمثلا Hepatitis Aو E
+
+195
+00:14:58,200 --> 00:15:04,540
+بينتقل عبر الفيكل oral بينما B بينتقل عبر الجنس و
+
+196
+00:15:04,540 --> 00:15:08,760
+عبر الدم و C بينتقل عبر الدم بالدرجة الأولى و يقال
+
+197
+00:15:08,760 --> 00:15:14,660
+ان هناك احتمالية انتقاله بالجنس مع دوما there are
+
+198
+00:15:14,660 --> 00:15:17,640
+two groups of human pathogen يقولنا الأولى ال
+
+199
+00:15:17,640 --> 00:15:21,580
+enterovirus والتانية ال rhinovirus لحظة ان واحد
+
+200
+00:15:21,580 --> 00:15:25,700
+بينتقل عبر ال intestinal tract والتانية عبر ال
+
+201
+00:15:25,700 --> 00:15:30,410
+respiratory كلمة rhinoأنف معناها راينو معناها أنف
+
+202
+00:15:30,410 --> 00:15:36,250
+فالراينو هو المسبب الرئيسي لل common cold قبل قليل
+
+203
+00:15:36,250 --> 00:15:43,930
+عرفنا مين كورونا كورونا virus بسبب الرشح وهي كمان
+
+204
+00:15:43,930 --> 00:15:51,590
+عندنا الراينو virus Calicivirus Calicivirus يعني
+
+205
+00:15:51,590 --> 00:15:56,110
+بنقدر نقول انه في السنوات الأخيرة اكتسب شهرة كبيرة
+
+206
+00:15:56,110 --> 00:16:02,390
+برضهخاصة في الدول الأوروبية و أصبح جزء رئيسي من
+
+207
+00:16:02,390 --> 00:16:08,330
+الأبحاث منصب على كيفية عزل هذا الفيروس من عينات
+
+208
+00:16:08,330 --> 00:16:13,510
+المياه، مياه الشر طبعا أو مياه الأنهار اللي تستخدم
+
+209
+00:16:13,510 --> 00:16:19,730
+بعد معارتها لمين لمياه الشرمن الأمثلة المهمة جدا
+
+210
+00:16:19,730 --> 00:16:24,590
+على هذا الفيروس هو الـ Norwalk أو Norwalk Virus و
+
+211
+00:16:24,590 --> 00:16:29,130
+Hepatitis E Virus و ال Hepatitis E Virus تم
+
+212
+00:16:29,130 --> 00:16:34,370
+تصنيفها مؤخرا في جيناس لحالها سموها Hippie Virus و
+
+213
+00:16:34,370 --> 00:16:38,150
+كلمة Hippie جاء من Hepatitis E يعني الـ E هذه
+
+214
+00:16:38,150 --> 00:16:43,590
+المضعفة للـ Hip هي لتصنيفها كHepatitis E اسمها
+
+215
+00:16:43,590 --> 00:16:49,340
+Hippie Virusبرضه الجينوم تباعها post-polarity و
+
+216
+00:16:49,340 --> 00:16:55,920
+non-segmented وايضا linear الريوفيروسز تعالوا نشوف
+
+217
+00:16:55,920 --> 00:17:00,200
+من ورا إيجا اسمها إيجا اسمها من تلت كلمات
+
+218
+00:17:00,200 --> 00:17:07,640
+respiratory enteric orphan إيش معنى orphan؟ يتيم
+
+219
+00:17:07,640 --> 00:17:14,140
+orphan معناها يتيم ليس مو يتيملأنه في ذاك الوقت
+
+220
+00:17:14,140 --> 00:17:18,440
+لما صمي بهذا الاسم هو الفيروس الوحيد اللي كان يعزل
+
+221
+00:17:18,440 --> 00:17:22,580
+من مكانين في نفس الوقت اللي هم ال respiratory
+
+222
+00:17:22,580 --> 00:17:26,680
+tract و من ال enteric tract تمام؟ فجالوا عنه
+
+223
+00:17:26,680 --> 00:17:31,480
+enteric او respiratory enteric orphan اللي الفيروس
+
+224
+00:17:31,480 --> 00:17:35,280
+الوحيد تمام؟ بالتانية لإن انا أخدنا أول حرف من كل
+
+225
+00:17:35,280 --> 00:17:40,820
+كلمة من تلات كلمات فصار عندي R E O فسميها Rio
+
+226
+00:17:40,820 --> 00:17:45,300
+virusبقولنا unique في التسمية يعني فريد بالتسمية
+
+227
+00:17:45,300 --> 00:17:50,860
+فريد بإنه بيحتوي على double-stranded RNA ومش هيك
+
+228
+00:17:50,860 --> 00:17:55,040
+بس فريد إنه بيحتوي على segmented أكبر عدد من ال
+
+229
+00:17:55,040 --> 00:17:58,760
+segments لحد الآن اللي عرفها في هذا الفيروس طبعا
+
+230
+00:17:58,760 --> 00:18:02,580
+بتكلم عن الفيروسات الطبية اللي هو ال 10 segments
+
+231
+00:18:02,580 --> 00:18:08,770
+يليه ال influenza كان عشرة segmentsمن المشهير تحت
+
+232
+00:18:08,770 --> 00:18:13,890
+هذه العائلة أو هذا ال genus هو ال rotavirus و ال
+
+233
+00:18:13,890 --> 00:18:18,870
+rotavirus شهرته في العالم الثالث كثيرة نظرا لأنه
+
+234
+00:18:18,870 --> 00:18:23,310
+بينتقل عبر الفكل oral route و مدينة بينتقل عبر
+
+235
+00:18:23,310 --> 00:18:27,650
+الفكل oral route في مناطق ال .. ال .. ال search
+
+236
+00:18:27,650 --> 00:18:32,770
+systemمش مكتمل فيها و ال .. و ال sewage treatment
+
+237
+00:18:32,770 --> 00:18:39,010
+مش فعالة مثلا احنا هنا في قطاع غزة فينا waste
+
+238
+00:18:39,010 --> 00:18:41,790
+water treatment plants، فينا واحدة في الشيخ أجلين،
+
+239
+00:18:41,790 --> 00:18:45,410
+واحدة في رفح، واحدة في الشمال، واحدة في منطقة
+
+240
+00:18:45,410 --> 00:18:51,140
+البريج على الحدود، يعني فيه موجودمحطات معالجة
+
+241
+00:18:51,140 --> 00:18:55,320
+للأسف محطات المعالجة انها شغلتين فيها ومشكلتين
+
+242
+00:18:55,320 --> 00:18:59,660
+فيها محتاج كهرباء والكهرباء انها وضعها سيئ دلغاية
+
+243
+00:18:59,660 --> 00:19:05,260
+الحجم تبعها .. الحجم تبعها لا يستوي بالكميات اللي
+
+244
+00:19:05,260 --> 00:19:09,160
+بتغطي المنطقة في بعض الأحيان بيضخ منها sewage
+
+245
+00:19:09,160 --> 00:19:14,460
+مباشرة غير معالج على مياه البحر وهذا طبعا بسبب
+
+246
+00:19:14,460 --> 00:19:18,700
+الماكرونات الصحية اللي اتحدثنا عنها مراراو تكرار
+
+247
+00:19:18,700 --> 00:19:24,420
+اذا لا كمية كافية ولا كهرباء والكهرباء رقم تلاتة
+
+248
+00:19:24,420 --> 00:19:28,660
+بعض الأحيان بنحتاج المعالجة مش معالجة واحدة في
+
+249
+00:19:28,660 --> 00:19:32,660
+معالجة primary و secondary و tertiary التيرشيري
+
+250
+00:19:32,660 --> 00:19:37,500
+لازم نعمل disinfection للمي المعالجة قبل ان هو
+
+251
+00:19:37,500 --> 00:19:42,120
+التخلص منهابعض الأحيان ما بنلاقيش المادة المستخدمة
+
+252
+00:19:42,120 --> 00:19:46,140
+في ال disinfection بكميات كافية لوضحها وبالتالي
+
+253
+00:19:46,140 --> 00:19:50,320
+ايضا يضخ حتى وان كانت معالجة هم سميها معالجة جزئيا
+
+254
+00:19:50,320 --> 00:19:55,120
+يعني treated, untreated or partially treated هذا
+
+255
+00:19:55,120 --> 00:20:00,760
+ما يضخ لنا على البحر فبالتالي انا ذكرتلكوا قبل هيك
+
+256
+00:20:00,760 --> 00:20:05,350
+في هذه المناسبات ان اكبر ملوث للمياهالمياه الشرب
+
+257
+00:20:05,350 --> 00:20:10,330
+والمياه الاستجمام هو المياه العادمة القادمة من
+
+258
+00:20:10,330 --> 00:20:15,970
+البشر تمام؟ والبشر يصابوا بأمراض منها فيروسية منها
+
+259
+00:20:15,970 --> 00:20:19,310
+ال Rotavirus منها Hepatitis A منها Hepatitis E
+
+260
+00:20:19,310 --> 00:20:25,210
+وبالتالي طبعا البعض يقولك أن البحر ما هو؟قدرته على
+
+261
+00:20:25,210 --> 00:20:30,550
+التطهير الذاتي لأنه مالح حولها أنا أقول نعم لديه
+
+262
+00:20:30,550 --> 00:20:34,470
+قدرة على التطهير الذاتي ولكن هذه القدرة محدودة
+
+263
+00:20:34,470 --> 00:20:40,150
+بعدين من يضمن لنا أنه الفيروس اللي دخل الآن في هذه
+
+264
+00:20:40,150 --> 00:20:46,170
+اللحظة هيموت في نفس اللحظة هناك variation في ال
+
+265
+00:20:46,170 --> 00:20:50,970
+survival time لل micro organism مثلا الإشليش
+
+266
+00:20:50,970 --> 00:20:54,750
+الكلية ممكن تعيش عدة ساعاتالانترو كوكاس ممكن تحيكش
+
+267
+00:20:54,750 --> 00:21:00,090
+عدة أيام وصل الصورة ففي اختلاف في ال survival rate
+
+268
+00:21:00,090 --> 00:21:04,210
+وهذه تنسوش ان ال pathogen مالهاش envelope مالهاش
+
+269
+00:21:04,210 --> 00:21:07,370
+envelope قدرتها على البقاء في ال environment بتكون
+
+270
+00:21:07,370 --> 00:21:11,810
+مالها اعلى من ال envelope virus طيب في كمان نقطتان
+
+271
+00:21:11,810 --> 00:21:16,070
+لازم نحكيها عن ال rotavirus انه له vaccine اللي هو
+
+272
+00:21:16,070 --> 00:21:20,850
+vaccine وقومني ادخل العام الماضي إلى فلسطين
+
+273
+00:21:20,850 --> 00:21:25,390
+rotavirusوانا من هنا بسأل السؤال بقول انه انتوا
+
+274
+00:21:25,390 --> 00:21:30,670
+بتعرفوا أثمان التطييمات بتكون مرتفعة يعني لو
+
+275
+00:21:30,670 --> 00:21:35,090
+تحدثنا عن خمس دولار للجرعة الواحدة وخلانا خمسين
+
+276
+00:21:35,090 --> 00:21:41,570
+ألف طفل بيولد سنويا خمسين في خمسة احسبوا الرقم اذا
+
+277
+00:21:41,570 --> 00:21:46,530
+كان اكتر من جرعة مايضرو في اتنين فالارقام المالية
+
+278
+00:21:46,530 --> 00:21:51,930
+المترتبة على ادخال تطييمات جديدة هي ارقام ضخمة هل
+
+279
+00:21:53,040 --> 00:21:56,620
+قمنا باتخاذ الفاكسين بناء على دراسة عرفنا جداش
+
+280
+00:21:56,620 --> 00:22:01,260
+بالفعل ال Rotavirus بيساهم في إمراض الأطفال اللي
+
+281
+00:22:01,260 --> 00:22:08,040
+عندنا في فلسطين، ماعرفناش، طيب، واحد بيقول طيب حتى
+
+282
+00:22:08,040 --> 00:22:11,700
+لو كانوا Gynecologistما هو الرقم اللي بندفع
+
+283
+00:22:11,700 --> 00:22:15,660
+المصاري، هذا بدي يحمي أطفالنا، صحيح، لدينا أولويات
+
+284
+00:22:15,660 --> 00:22:19,060
+يا جماعة، لدينا أولويات، يعني لو المبلغ هذا تم
+
+285
+00:22:19,060 --> 00:22:26,910
+صرفه في اتجاه آخر، يوفر علي أمراض أخرى بـمضاعفات
+
+286
+00:22:26,910 --> 00:22:32,390
+أصعب بنسب وفيات أعلى يمكن يكون هذا التوجه أفضل
+
+287
+00:22:32,390 --> 00:22:37,970
+لذلك احنا بنقول و بنشجع ان بالفعل اي قرارات سياسية
+
+288
+00:22:37,970 --> 00:22:43,650
+صحية يقريبا تكون مبنية على دراسات محلية و ليس
+
+289
+00:22:43,650 --> 00:22:48,370
+دراسات أجنبية و كان في مثال صعب للغاية لما في 2011
+
+290
+00:22:48,370 --> 00:22:51,030
+أدخله ال vaccine تبع ال
+
+291
+00:22:54,430 --> 00:22:59,290
+دراسات روحنا نعمل دراسة نشوف ماذا تأثير على
+
+292
+00:22:59,290 --> 00:23:03,430
+الفاكسين قبل يعني ايه ايه لما دخلنا ايش صار في
+
+293
+00:23:03,430 --> 00:23:07,170
+السترتو كوكاس نيمونيا بعد فلما روحنا ندور على
+
+294
+00:23:07,170 --> 00:23:12,670
+سجلات قبل مالاجيناش استرتو كوكاس نيمونيا ولا بعد
+
+295
+00:23:12,670 --> 00:23:17,370
+لاجينا فمالحاج انه اصلا ادخل الفاكسين دون ما
+
+296
+00:23:17,370 --> 00:23:23,060
+الحاجة لهذا الفاكسينبناء على توقعات أو بناء على
+
+297
+00:23:23,060 --> 00:23:31,340
+توصيات من أماكن أخرى غير فلسطين لذلك نقول أي تغيير
+
+298
+00:23:31,340 --> 00:23:36,480
+أو أي intervention صحي كسياسة عامة لابد أن يكون
+
+299
+00:23:36,480 --> 00:23:42,950
+مبني على دراسات ونتائج دراسات محليةالفلاجو فيروس
+
+300
+00:23:42,950 --> 00:23:47,690
+من أشهر أمثلته اللي هم ال yellow fever virus و ال
+
+301
+00:23:47,690 --> 00:23:51,670
+ding أو ال dingy virus و قلنا لك الدنجي فيروس اسمه
+
+302
+00:23:51,670 --> 00:23:56,170
+بالعربي حمضلك تمام مشهورة انها موجودة في السعودية
+
+303
+00:23:56,170 --> 00:24:00,930
+و موجودة في اليمن طبعا في دول جنوب شرق أسيا أمر
+
+304
+00:24:00,930 --> 00:24:06,010
+طبيعي ان يكون فيهم دنجي فيروس ال yellow و ال dingy
+
+305
+00:24:06,010 --> 00:24:09,050
+و ال west mile ال virus تلتها بينتقل عبر البعوض
+
+306
+00:24:11,330 --> 00:24:17,430
+وخلينا نتكلم عن البعوض كنقل للأمراض الفيروسية طبعا
+
+307
+00:24:17,430 --> 00:24:21,190
+بتعرفوا أن البعوض أنواع مش نوع واحد أنواع وسلالات
+
+308
+00:24:21,190 --> 00:24:28,330
+كثيرة ومتنوعة منها ما ينقل أمراض مخصصة ومنها لا
+
+309
+00:24:28,330 --> 00:24:34,190
+يعيش إلا في مناطق مخصصة بمعنى الملاريا احنا لدينا
+
+310
+00:24:34,190 --> 00:24:38,390
+ملاريا فقط في فلسطين ماعناش ملاريا ليش ماعناش
+
+311
+00:24:38,390 --> 00:24:46,270
+ملاريا؟ماعناش اللي هو البعوض الناقل للملاريال اللي
+
+312
+00:24:46,270 --> 00:24:49,610
+انا بدأ اوصله لرسالة بس لوصلها تعرفوا زيكا فيروس
+
+313
+00:24:49,610 --> 00:24:53,310
+سمعتوا في زيكا فيروس السنة الماضية او اللي جابلها
+
+314
+00:24:53,310 --> 00:24:56,790
+كان هو نجم الأخبار و احنا عملنا عنه محاضرات في
+
+315
+00:24:56,790 --> 00:25:00,910
+الجامعة حتى للتعريف بزيكا فيروس اللي كان بسبب
+
+316
+00:25:00,910 --> 00:25:04,010
+الأطفال لأنهم microcephaly لرسوم صغيرة رسوم بتكون
+
+317
+00:25:04,010 --> 00:25:10,240
+صغيرةهذه الذيكا في منطقة في أفريقيا أعتقد في زئير
+
+318
+00:25:10,240 --> 00:25:16,060
+مش بتأكد الدولة الأفريقية لكن الان وين المرض؟ في
+
+319
+00:25:16,060 --> 00:25:16,600
+برازيل
+
+320
+00:25:19,440 --> 00:25:26,640
+اليوم نحن في عصر انتقال البشر والحيوانات والطيور
+
+321
+00:25:26,640 --> 00:25:29,660
+من أول الطيور، هي الوحيدة اللي كانت أصلا تنتقل
+
+322
+00:25:29,660 --> 00:25:34,480
+بسهولة، بعدين صارنا احنا، وبعدين صارت الحيوانات،
+
+323
+00:25:34,480 --> 00:25:37,220
+تمشي معاها الجوردان تطلع بعد جت معاها نفسها،
+
+324
+00:25:37,220 --> 00:25:40,720
+الجوردان انتقلت حول العالم بقى بالسفنبالصفن اللي
+
+325
+00:25:40,720 --> 00:25:44,380
+.. اللي كانت تنتقل من مكان إلى مكان الكويرة اللي
+
+326
+00:25:44,380 --> 00:25:49,120
+هي البكتيريا بجت تنتقل برضه بالصفن من ال .. من ..
+
+327
+00:25:49,120 --> 00:25:52,480
+من دولة إلى دولة انتوا عارفين ان في أحد السنوات
+
+328
+00:25:52,480 --> 00:25:57,660
+منيع الحج من الهند بقرار هندي .. بقرار هندي لما
+
+329
+00:25:57,660 --> 00:26:02,160
+كان حاكم الهند مسلم .. كان حاكم الهند مسلم لماذا
+
+330
+00:26:02,160 --> 00:26:08,650
+الحجاج الهند ..اللي هون بشكل عام لديهم معتقدات
+
+331
+00:26:08,650 --> 00:26:12,250
+غريبة و عجيبة مثلا عندهم نهر ال gang هذا نهر ال
+
+332
+00:26:12,250 --> 00:26:16,430
+gang بيستحموا فيه و بتبروا ماء مقدس يعني اللي
+
+333
+00:26:16,430 --> 00:26:20,630
+بيستحمى فيه بطيب طبعا لو تطلع على منظر المياه اللي
+
+334
+00:26:20,630 --> 00:26:25,890
+فيه يعني هو مش .. مش نهر .. يعني نهر نظيف لأ نهر
+
+335
+00:26:25,890 --> 00:26:29,490
+بالفعل قدرات و ممكن تلاقي فيه أشياء ميتة يعني
+
+336
+00:26:29,490 --> 00:26:30,650
+مصائب
+
+337
+00:26:32,750 --> 00:26:36,990
+فيبدو أن حتى ال .. ال .. ال .. ال .. الديانات
+
+338
+00:26:36,990 --> 00:26:39,870
+الأخرى اللي غير الهندوسية بتأثر بالثقافات، يعني
+
+339
+00:26:39,870 --> 00:26:45,030
+بتأثروا بعض، فالمهم أن انتشار الكورة في الهند كان
+
+340
+00:26:45,030 --> 00:26:49,590
+أمر طبيعي، فطلع مجموعة من الحجاج على مكة في أحد
+
+341
+00:26:49,590 --> 00:26:54,550
+السنواتو .. يعني .. يعني يذكر .. الحاجة تذكر أنه
+
+342
+00:26:54,550 --> 00:26:59,350
+من .. من أربعين ألف حاج مغربي لم يعد إلا خمسة ألف
+
+343
+00:26:59,350 --> 00:27:02,990
+أو ستة ألف، رقم بسيط جدا من الحجاج اللي عاد سالمو
+
+344
+00:27:02,990 --> 00:27:07,290
+الباجي توفي في طريقه و هو مروح من الحاجة، من مرض
+
+345
+00:27:07,290 --> 00:27:14,000
+الكوليرا، الآن الكوليرا هو الموجودةفي كل الدنيا
+
+346
+00:27:14,000 --> 00:27:16,680
+طبعا بيانة على المعلومات هذه اللي حكيتها هنا
+
+347
+00:27:16,680 --> 00:27:20,460
+الحاكم الهندي السنة اللي بعديها منع قولنا الحج
+
+348
+00:27:20,460 --> 00:27:28,540
+لأسباب صحية كانوا يعملوا حجر الصحي الأمراض تنتقل
+
+349
+00:27:28,540 --> 00:27:33,340
+ومناقلاتها الآن تنتقل وفي عامل جديد دخل على الساحة
+
+350
+00:27:33,340 --> 00:27:36,320
+اللي هو ال global warming اللي هو اللي بيعمل
+
+351
+00:27:36,320 --> 00:27:41,400
+climate change أو التغيرات المناخيةاللي صار فيه
+
+352
+00:27:41,400 --> 00:27:45,000
+prediction من .. من قبل بعض العلماء ان بعض الدول
+
+353
+00:27:45,000 --> 00:27:49,060
+هتغرق، هتختفي تماما زي Bangladesh، تمام؟ وبعض
+
+354
+00:27:49,060 --> 00:27:52,960
+الدول الصحراوية زي السعودية مثلا، هتصبح خضراء،
+
+355
+00:27:52,960 --> 00:27:56,300
+يعني من كثرة الأمطار، يعني حصي في توزيع مختلف
+
+356
+00:27:56,300 --> 00:27:59,600
+للأمطار والمياه وارتفاع درجة الحرارة في الأماكن
+
+357
+00:27:59,600 --> 00:28:03,140
+وانخفاضها في أماكن أخرى من كوكب الأرض، هتسموه
+
+358
+00:28:03,140 --> 00:28:06,870
+التغيرات المناخيةطبعا البعض لحد الآن بيظن ان هذا
+
+359
+00:28:06,870 --> 00:28:14,410
+خيال علمى بس الحقيقة انه بدأنا نلمس نتاجة وبالتالي
+
+360
+00:28:14,410 --> 00:28:19,010
+نواقل للحشرات اللى لم تكن قادرة على المعيشة في
+
+361
+00:28:19,010 --> 00:28:23,470
+مكان Xستصبح قادر على هذا ال .. ال .. ال .. او على
+
+362
+00:28:23,470 --> 00:28:27,710
+هذه المعيشة و التكاثر فيها و بالتالي مابنداش نقول
+
+363
+00:28:27,710 --> 00:28:31,170
+ان احنا هذا الفيروس ليس موجود عندنا او هذا ال ..
+
+364
+00:28:31,170 --> 00:28:35,050
+ال .. المرض ليس موجود عندنا في المستقبل القريب زي
+
+365
+00:28:35,050 --> 00:28:39,190
+ما ال internet عمل العالم قرية صغيرة ايضا ال .. ال
+
+366
+00:28:39,190 --> 00:28:43,110
+global warming هيعمل العالم قرية صغيرة بس بالنسبة
+
+367
+00:28:43,110 --> 00:28:49,180
+لمن؟ للحشرات و الأمراض و القواتالفيروس اللى بيختلف
+
+368
+00:28:49,180 --> 00:28:52,680
+عنهم الصحيح بينتقلش عن طريق ال .. ال .. بينتقلش عن
+
+369
+00:28:52,680 --> 00:28:55,440
+طريق اللى هو البعوض اللى هو الهيبوتايتس C و بينتقل
+
+370
+00:28:55,440 --> 00:29:01,720
+عن طريق الدم والهيبوتايتس C ليس له vaccine فعال
+
+371
+00:29:01,720 --> 00:29:07,440
+صحيح جديد لجوله drug كويس very expensive بيسموه
+
+372
+00:29:07,440 --> 00:29:12,390
+Sovaldi وهذا ال drug يعني ..خلّيني نقول أعطى فرص
+
+373
+00:29:12,390 --> 00:29:17,370
+أمل للشفاء لأنه ناس كثيرة كانت نسبة الأمل عندهم
+
+374
+00:29:17,370 --> 00:29:22,090
+معدومة تقريبا من Hepatitis C أحد مساوئي Hepatitis
+
+375
+00:29:22,090 --> 00:29:25,890
+C أن الـComplication تبع طلبانات بتعمل Cancer فهو
+
+376
+00:29:25,890 --> 00:29:33,990
+من مسببات أيضا ال Cancer Toga
+
+377
+00:29:33,990 --> 00:29:34,470
+Virus
+
+378
+00:29:37,680 --> 00:29:42,160
+في تنين جروب من التوجه فيروس هما ال alpha virus و
+
+379
+00:29:42,160 --> 00:29:46,580
+ال ruby virus ال alpha virus بيعمل أو بيشمل على
+
+380
+00:29:46,580 --> 00:29:50,420
+فيروسين مهمين eastern and western encephalitis
+
+381
+00:29:50,420 --> 00:29:55,860
+virus واضح انه تسمي eastern و western على الأماكن
+
+382
+00:29:55,860 --> 00:29:59,660
+اللي عزل منها هذا الفيروس لكن المرض هو
+
+383
+00:29:59,660 --> 00:30:02,680
+encephalitis و ال encephalitis هي التهاب الدماغ
+
+384
+00:30:02,680 --> 00:30:06,820
+وهو مرض خطير جداالروبي فايروس بالنسبة ان احنا في
+
+385
+00:30:06,820 --> 00:30:12,940
+فلسطين اهم كتير من اللي هو رقم واحد روبي ماخوذ منه
+
+386
+00:30:12,940 --> 00:30:16,140
+كلمة Rubella Rubella اللي هي ال German missiles
+
+387
+00:30:16,140 --> 00:30:19,720
+الحصبة الألمانية اللي اتحدثنا عنها المحاضرة
+
+388
+00:30:19,720 --> 00:30:25,880
+السابقة كان لها اسم لذيذ اسم حصبة التلات أيام حصبة
+
+389
+00:30:25,880 --> 00:30:32,790
+التلات أيام ليش حصبة التلات أيام لأنهعنا الطفل
+
+390
+00:30:32,790 --> 00:30:36,350
+اللى بيطلع عليه اللى هو او بيطلع عليه ال .. ال
+
+391
+00:30:36,350 --> 00:30:40,370
+maculopapular rashes ال rashes اللى طفح الجلدى كان
+
+392
+00:30:40,370 --> 00:30:45,130
+بيستمر تقريبا الى تلت أيام فسموها حصبة التلت أيام
+
+393
+00:30:45,130 --> 00:30:49,310
+عشان يميزوها عن مين؟ عن ال missiles اللى هى الأخرى
+
+394
+00:30:49,310 --> 00:30:54,910
+اللى كانت تاخد وقت طبعا أطول اسمها اسم المرض
+
+395
+00:30:54,910 --> 00:31:01,260
+German missiles و ال .. من ..طرق انتقالها أو طريقة
+
+396
+00:31:01,260 --> 00:31:06,940
+انتقالها غالبا عبر ال respiratory tract وخطرتها
+
+397
+00:31:06,940 --> 00:31:12,360
+اكثر عندما اتحدث عن .. عندما اتحدث عن اللي هو
+
+398
+00:31:12,360 --> 00:31:21,030
+الجنين و الأم الحامل كلما أصيبت المرأة الحاملفي سن
+
+399
+00:31:21,030 --> 00:31:24,790
+أو مش في سن في عمر مبكر من الحمل يعني في الأشهر
+
+400
+00:31:24,790 --> 00:31:30,290
+الأولى بيكون الأمر أخطر من مين؟ من الأشهر المتقدمة
+
+401
+00:31:30,290 --> 00:31:33,210
+يعني في ال first trimester أخطر من ال second
+
+402
+00:31:33,210 --> 00:31:37,630
+trimester أخطر من ال third trimester شوفوا الآن
+
+403
+00:31:37,630 --> 00:31:42,210
+الرقم اللي مذكور عنه على اللوحة هنا عشرين بالمائة
+
+404
+00:31:42,210 --> 00:31:48,270
+فرصة ان الجنين يصير عنده complications أو
+
+405
+00:31:48,270 --> 00:31:54,650
+deformitiesبتكون عالية هذه الفرصة متى؟ في بداية ال
+
+406
+00:31:54,650 --> 00:31:58,750
+pregnancy، في بداية اللي هو الحمض زي إيش فينا
+
+407
+00:31:58,750 --> 00:32:04,510
+deformities أو complications ممكن تحصلت للجنين؟
+
+408
+00:32:04,510 --> 00:32:10,090
+واحد، deafness، فقدان السماء، cataract، مشكلة في
+
+409
+00:32:10,090 --> 00:32:12,710
+العين، heart defects اللي هي الميهة البيضاء،
+
+410
+00:32:12,710 --> 00:32:17,160
+بيسموها الميهة البيضاءHeart defects خلل فيه عوضة
+
+411
+00:32:17,160 --> 00:32:22,200
+القلب Mental retardation تخلف ذهني أو عقلي and
+
+412
+00:32:22,200 --> 00:32:26,900
+liver and spleen damage إذا في مخاطر كبيرة و قد
+
+413
+00:32:26,900 --> 00:32:31,040
+يصل الأمر يبنيها إلى أنه يصير فيه abortion أو أن
+
+414
+00:32:31,040 --> 00:32:36,340
+الطفل يولد ميتا إذا فينا مخاطر كبيرة من الربلة على
+
+415
+00:32:36,340 --> 00:32:41,400
+الأم الحامل و أنا ذكرت لكم في محاضرة سابقةبإنه فيه
+
+416
+00:32:41,400 --> 00:32:47,920
+تطايم جرعة انشطية للبنات مش للذكور للبنات في سن
+
+417
+00:32:47,920 --> 00:32:51,540
+الزواج اللي هو السن الأددية او من سن بدء الزواج
+
+418
+00:32:51,540 --> 00:32:56,580
+اللي هو السن الأددىطبعا احنا بناخد فاكسين و
+
+419
+00:32:56,580 --> 00:33:01,100
+الفاكسين هذا اسمه MMR و لو طلعتوا على بطاقاتكم
+
+420
+00:33:01,100 --> 00:33:06,760
+التطييم او على خدكم الصغار بتلاقوا ال MMR جزء
+
+421
+00:33:06,760 --> 00:33:10,040
+أساسي من التطييمات اللي بياخدها الأطفال في فلسطين
+
+422
+00:33:10,040 --> 00:33:16,000
+و بيبدأ التطييم من 12 إلى 15 شهر و ليس قبل و هنا
+
+423
+00:33:16,000 --> 00:33:21,100
+لابد ان نقف عند هذا الرقم و لماذا؟ بعضالأمراض
+
+424
+00:33:21,100 --> 00:33:24,140
+بنطعملها من أول يوم و أمراض أخرى بنطعملها بعد أربع
+
+425
+00:33:24,140 --> 00:33:28,080
+شهور و بعد ست شهور، هل هو مزاج يعني و انتقائي ولا
+
+426
+00:33:28,080 --> 00:33:32,040
+في أكيد أسباب؟ في أكيد أسباب، أحد الأسباب اللي هنا
+
+427
+00:33:32,040 --> 00:33:37,600
+إن طالما الـM أصلا مطعمة للـMMR، يبقى المولود
+
+428
+00:33:37,600 --> 00:33:42,860
+هيحتوي في رسمه أو في دمه على IgG، immunoglobulins
+
+429
+00:33:43,900 --> 00:33:49,380
+الان لو انا حاطط الطفل antigen للروبيلا ال
+
+430
+00:33:49,380 --> 00:33:53,740
+antibodies اللى موجودة في رسم الطفل هتتفاعل و تعمل
+
+431
+00:33:53,740 --> 00:33:56,200
+ال neutralization لمن؟ للفيروس
+
+432
+00:33:59,290 --> 00:34:03,290
+مناعة الطفل اللي أخدها من الأم عملت interference
+
+433
+00:34:03,290 --> 00:34:07,810
+مع ال vaccination هدف ال vaccine أن يستثير جهاز
+
+434
+00:34:07,810 --> 00:34:12,170
+المناعة لإنتاج أجسام مضادة لكن للأسف الأجسام
+
+435
+00:34:12,170 --> 00:34:16,190
+المضادة اللي موجودة في رسم الطفل ارتبط لمين فبتالي
+
+436
+00:34:16,190 --> 00:34:21,230
+أجلنا ال vaccine إلى سن بتكون ال antibodies اللي
+
+437
+00:34:21,230 --> 00:34:26,110
+أخدها من الأم قد بدأت تذوي أو تفقد أو تعدم
+
+438
+00:34:26,110 --> 00:34:31,430
+وبالتالي بنعطيه ال vaccine في هذه الفترةالان كلمة
+
+439
+00:34:31,430 --> 00:34:38,010
+second dose تقطعتها على أربع إلى ستة سنوات وكنا
+
+440
+00:34:38,010 --> 00:34:41,630
+before kindergarten اللي هي الروضة أو الحضانة
+
+441
+00:34:41,630 --> 00:34:46,230
+بيسموها و ال first grade اللي هو الصف الأول الجرعة
+
+442
+00:34:46,230 --> 00:34:49,930
+الثانية في فرق بينها و بين الأولى حوالى تلت سنوات
+
+443
+00:34:49,930 --> 00:34:57,110
+ولا لا إلى أربع سنوات هذا الفرق الكبير مهم جدا
+
+444
+00:34:58,320 --> 00:35:03,260
+الطفل كون أجسام مضادة في الجرعة الأولى وصار عنده
+
+445
+00:35:03,260 --> 00:35:08,500
+immune response بشكل إنتاج antibody و memory cells
+
+446
+00:35:08,500 --> 00:35:15,360
+خلايا ذاكرة لما بنعطيه جرعة منشطة ليها second dose
+
+447
+00:35:15,360 --> 00:35:18,940
+ايش بيسمي الجرعة منشطة باللغة الإنجليزية بوستر دوس
+
+448
+00:35:18,940 --> 00:35:26,380
+بوستر دوس بسميها جرعة منشطة او جرعة دايمة جرعة
+
+449
+00:35:26,380 --> 00:35:32,230
+دايمةالـ Response في الجرعة الدائمة بيكون أقوى
+
+450
+00:35:32,230 --> 00:35:36,790
+بكثير من الجرعة الأولى لإن فيها الناس الأهم memory
+
+451
+00:35:36,790 --> 00:35:42,910
+cells الجهاز المنع مازال يتذكر هذا الفيروس ومازال
+
+452
+00:35:42,910 --> 00:35:47,110
+يتذكر كيف يمكن أن ينتج له أجسام مضادة وبتالي بكل
+
+453
+00:35:47,110 --> 00:35:52,400
+سهولة بينتجله كمية كبيرةالفيروس الخامس ال retro
+
+454
+00:35:52,400 --> 00:35:55,680
+virus و ال retro pertains to the reverse
+
+455
+00:35:55,680 --> 00:35:58,860
+transcription of the RNA genome to DNA احنا بنعرف
+
+456
+00:35:58,860 --> 00:36:03,640
+انه DNA ل RNA الوضع الطبيعي هذا من RNA إلى DNA two
+
+457
+00:36:03,640 --> 00:36:08,360
+groups حد يسميها linty virus و حد يسميها onco
+
+458
+00:36:08,360 --> 00:36:13,720
+virus onco يعني مسبب للأورام و ال linty small زي
+
+459
+00:36:13,720 --> 00:36:19,160
+العدس من لنتل لنتل معناها عدس امام؟ very small
+
+460
+00:36:19,160 --> 00:36:24,310
+virusesو بينجو سينج كانت بيعنى slow virus slow
+
+461
+00:36:24,310 --> 00:36:27,930
+virus لإنه يمكن سمعته بأن ناس أصيبوا أعلن عن
+
+462
+00:36:27,930 --> 00:36:31,130
+أنفسهم إنهم مصابين من المشاهير من المصابين بال
+
+463
+00:36:31,130 --> 00:36:34,350
+AIDS زي واحد اسمه magic johnson كان لاعب كرة سلة
+
+464
+00:36:34,350 --> 00:36:40,130
+مشهور جدا في العالم أعلن إنه مصاب بال HIV فحص واحد
+
+465
+00:36:40,130 --> 00:36:44,530
+اللي كان عنده HIV لكن رجع يلعب كرة سلة عادي
+
+466
+00:36:44,530 --> 00:36:47,890
+ومابتعرفش إيش طبعا أنا مش بتبين هذا الكلام جاب
+
+467
+00:36:47,890 --> 00:36:52,340
+العشرين سنة يمكن تمام؟فالفيروس بيصنع من ال slow
+
+468
+00:36:52,340 --> 00:36:57,740
+virus من أشهر هذه الفيروسات اللي هو ال HIV virus
+
+469
+00:36:57,740 --> 00:37:01,360
+في فيروسات بتصيب الحيوانات لكن لو بتصيبش الإنسان
+
+470
+00:37:01,360 --> 00:37:06,540
+من نفس الفصيلة اسمها Vesna virus ال Omcoviruses في
+
+471
+00:37:06,540 --> 00:37:10,920
+مثال عليها مشهور جدا بتصيب الإنسان اللي هو human T
+
+472
+00:37:10,920 --> 00:37:17,140
+cell leukemia virus HTLV human T cell leukemia
+
+473
+00:37:17,140 --> 00:37:22,650
+virusالارثوميكس فيروس حاكينا عنها هنا هي اللي ..
+
+474
+00:37:22,650 --> 00:37:25,310
+اللي بتاعة ال influenza وانا دايما بقول ال
+
+475
+00:37:25,310 --> 00:37:28,110
+influenza فيروس واحدة من أهم الفيروسات على كوكب
+
+476
+00:37:28,110 --> 00:37:32,370
+الأرض اللي كل سبع إلى عشر سنوات بتفاجئنا بسلولة
+
+477
+00:37:32,370 --> 00:37:35,790
+جديدة بطلنا .. بطلنا .. بطلنا نتفاجأ من أننا
+
+478
+00:37:35,790 --> 00:37:38,710
+مابنعرفش بجهة بطلنا نتفاجأ من هذه السلولات الجديدة
+
+479
+00:37:40,220 --> 00:37:45,660
+الـ Paramyxovirus بتشمل مجموعة مهمة جدا من
+
+480
+00:37:45,660 --> 00:37:50,120
+الفيروسات زي الميسلز والمامبس والميسلز بنات زي ما
+
+481
+00:37:50,120 --> 00:37:54,380
+ذكرتلكوا كانت في السابق يعني نسبة الوفيات فيها قد
+
+482
+00:37:54,380 --> 00:37:59,040
+تصل إلى خمسين بالمائة قبل ال vaccination، المامبس
+
+483
+00:38:00,280 --> 00:38:03,560
+للأسف كانت فعلا عدد سيء عندنا الصغار لما كان الطفل
+
+484
+00:38:03,560 --> 00:38:06,960
+يصاب بال mumps تمام؟ طبعا نسبة كبيرة من الأطفال
+
+485
+00:38:06,960 --> 00:38:10,620
+كانوا يصاب بال mumps كانوا يخدهم على حد يدعى شيخ
+
+486
+00:38:10,620 --> 00:38:14,420
+هو مش شيخ يكتبله آية الكورسي على خده تمام؟ يعني
+
+487
+00:38:14,420 --> 00:38:19,140
+استشفاء بالقرآن وهذا كان بينم عن مين؟ عن جهل مدقق
+
+488
+00:38:19,140 --> 00:38:21,940
+لأن الطفل كان يروح الحمام ويطلع من الحمام وهو
+
+489
+00:38:21,940 --> 00:38:26,500
+مكتوب عليه هذه الكلمة للأسف هذه كانت موجودة بكثرة
+
+490
+00:38:26,500 --> 00:38:31,230
+لأن بالفعل الناس جهل وانا دايما بقول جهلالعلماء
+
+491
+00:38:31,230 --> 00:38:35,330
+وجهل المثقفين أسوأ مليون مرة من جهل مين؟ من جهل
+
+492
+00:38:35,330 --> 00:38:40,190
+العامة لأن العالم الجاهل يعني هو كيف يكون عالم
+
+493
+00:38:40,190 --> 00:38:47,330
+جاهل في نفس الوقت مش ذاك هو ده لا بس موجود زي اللي
+
+494
+00:38:47,330 --> 00:38:50,830
+احنا حكينا عنه قبل قليل عامل حاله انه شيخ لكن هو
+
+495
+00:38:50,830 --> 00:38:56,590
+يجهل ان هذا الكلام اللي بيعمله غير جائز شرعميسلز
+
+496
+00:38:56,590 --> 00:38:59,770
+مامس من الأمراض الخطيرة ضفنا عليهم الربلا صار
+
+497
+00:38:59,770 --> 00:39:05,110
+علينا MMR ميسلز مامس and ربلا ايضا ال para
+
+498
+00:39:05,110 --> 00:39:07,750
+influenza واضح من كلمة para influenza انها بتعمل
+
+499
+00:39:07,750 --> 00:39:11,490
+disease بيشبه ال influenza و الرعب اللي هو ال
+
+500
+00:39:11,490 --> 00:39:14,330
+respiratory syncytia الفيروس اللي قلنالكوا هو
+
+501
+00:39:14,330 --> 00:39:18,430
+بيعمل syncytia طبعا هذه الصورة على طفل عنده منتفق
+
+502
+00:39:18,430 --> 00:39:23,610
+الأوداج لان ال مامس بصيب اللي هو الغدة النكافية
+
+503
+00:39:23,610 --> 00:39:28,210
+اللي بيسموها ParatoidIt's a livery gland هذه
+
+504
+00:39:28,210 --> 00:39:35,930
+الصورة بتضيين الرشد على رسم طفل على رسم طفل مصاب
+
+505
+00:39:35,930 --> 00:39:39,550
+بالحصبة تشبه ال German missiles اللي شفناها لكن
+
+506
+00:39:39,550 --> 00:39:44,070
+ميزنا بيها نقول لكوا في الفترة الزمنيةالربدوفيروس
+
+507
+00:39:44,070 --> 00:39:49,050
+هو الفيروس اللي بيشبه ال bullet أو الرصاصة وبينتمي
+
+508
+00:39:49,050 --> 00:39:53,230
+له ال rabies virus وهو الوحيد اللي important human
+
+509
+00:39:53,230 --> 00:39:55,950
+pathogen ويمكن تحدثت عنه المرة الماضية وقلتلكوا
+
+510
+00:39:55,950 --> 00:39:59,670
+انه صار فيه change بالظبط صار فيه change في ال
+
+511
+00:39:59,670 --> 00:40:03,290
+epidemiology لهذا ال .. ال .. ال virus من خلال
+
+512
+00:40:03,290 --> 00:40:07,230
+الانتقال كان انتقل عن طريق الكلاب و بعض الحيوانات
+
+513
+00:40:07,230 --> 00:40:10,750
+اتضلى لكن الان بنتقل اكتر شي عن طريق الخلافيشي
+
+514
+00:40:11,050 --> 00:40:15,870
+الصورة اللي تحتها بتبين لي تم تم يعني معناها
+
+515
+00:40:15,870 --> 00:40:19,610
+transmission electron microscope و فيه sim اللي هي
+
+516
+00:40:19,610 --> 00:40:22,450
+scanning electron microscope فدول تم تم مشهورين
+
+517
+00:40:22,450 --> 00:40:25,530
+sim و تم لازم تكونوا عارفينهم تم معناها
+
+518
+00:40:25,530 --> 00:40:29,350
+transmissionو الـ SIM يعني Scanning بيعطينا صورة
+
+519
+00:40:29,350 --> 00:40:35,030
+من الخارج والترانزميشن يعطينا صورة من الداخل هنا
+
+520
+00:40:35,030 --> 00:40:42,230
+في نسيج و مليء بالـ Bullet shape virus particle من
+
+521
+00:40:42,230 --> 00:40:48,310
+ال rabies virus الفيلو فيروسفيه اللي قلنا انا
+
+522
+00:40:48,310 --> 00:40:51,470
+هخيطيه واخدنا عليه مثالين اللي هم مين Ebola and
+
+523
+00:40:51,470 --> 00:40:56,990
+Marburg و Highly Paleomorphic اول مرة يمر معانا
+
+524
+00:40:56,990 --> 00:41:00,630
+مصطلح Paleomorphic في الفيروسات كان يمر معانا وين؟
+
+525
+00:41:00,630 --> 00:41:05,330
+في البكتيريا، البكتيريا لما تكونتمتلك أشكال أو
+
+526
+00:41:05,330 --> 00:41:09,370
+يدها المقدرة علي إنها تغير شكلها مرارا وتكرارا
+
+527
+00:41:09,370 --> 00:41:13,550
+تمام أو حاجاتها مختلفة نسميها paleomorphic طبعا
+
+528
+00:41:13,550 --> 00:41:19,540
+لأن خيطي أكيد ممكن ينحني بأشكال مختلفةالـ
+
+529
+00:41:19,540 --> 00:41:23,880
+Coronavirus أظن حلو للفيروس هذا جميل الصورة تبعته
+
+530
+00:41:23,880 --> 00:41:27,900
+ومن هنا أطلق عليه Corona لأن الـ Glycoprotein
+
+531
+00:41:27,900 --> 00:41:33,360
+تبعته مصفوفة بشكل تاج فسموها Coronavirus طبعا ال
+
+532
+00:41:33,360 --> 00:41:38,860
+Coronavirus من أشهر الأمراض بيننا الـ SARS و الـ
+
+533
+00:41:38,860 --> 00:41:44,840
+MERS-CoVirus السعودية وأيضا بتسببنا الرشح ال Arena
+
+534
+00:41:44,840 --> 00:41:49,420
+Virus طلع الفيروس هنا جواهتلاقوا اللي هو مين الـ
+
+535
+00:41:49,420 --> 00:41:51,780
+ribosomes اللي احنا حكينا عنهم اللي سمناهم non
+
+536
+00:41:51,780 --> 00:41:55,880
+-functional ribosomes من أشهر ال pathogens اللي
+
+537
+00:41:55,880 --> 00:41:58,420
+مولودة في هذه السلسلة ال lymphocytic
+
+538
+00:41:58,420 --> 00:42:03,340
+choriomeningitis virus أو LCV واللاسة fever وكلا
+
+539
+00:42:03,340 --> 00:42:06,280
+هما من الفيروسات من الفيروسات أيضا الخطيرة
+
+540
+00:42:06,280 --> 00:42:10,760
+البنيافيروس أيضا من الفيروسات الخطيرة وعليه أمثلة
+
+541
+00:42:10,760 --> 00:42:16,120
+اللي هم ال Korean hemorrhagic feverحمة الكورية
+
+542
+00:42:16,120 --> 00:42:21,700
+النزفية والهانتا فيروس والسين نومبري فيروس التلاتة
+
+543
+00:42:21,700 --> 00:42:26,380
+أسماءهم عندما تذكر في عالم الفيروسات تثير القشعيرة
+
+544
+00:42:26,380 --> 00:42:32,460
+زي إيبولا وزي ماربورج فيروس أي فيروس بيعمل حمة
+
+545
+00:42:32,460 --> 00:42:37,840
+نزفية معناه الحق إنه هذا ممكن يدمر organs في الجسم
+
+546
+00:42:37,840 --> 00:42:43,450
+ويمكن يدمر الجسم بشكل كبيرالاخير في السلسلة وهو
+
+547
+00:42:43,450 --> 00:42:46,830
+الشهير جدا صعب بالنسبة إلى ان هو الـ Delta Virus
+
+548
+00:42:46,830 --> 00:42:53,210
+وشهرته نجت من ان هو defective virus ولا يمكن أن
+
+549
+00:42:53,210 --> 00:42:58,290
+يصيب الإنسان إلا إذا كان بي موجود ففي بي ممكن
+
+550
+00:42:58,290 --> 00:43:06,710
+التلاني يدخلوا مع بعض او ممكن ييجي D لاحقا بيسموه
+
+551
+00:43:06,710 --> 00:43:11,950
+D on top of BD on top يعني إنه جاي بعد اللي هو
+
+552
+00:43:11,950 --> 00:43:15,630
+الـB أو إنه يكونوا الاتنين جايين مع بعض وعلى فكرة
+
+553
+00:43:15,630 --> 00:43:18,410
+ال outcome تبقى ال infection بيختلف إذا كانوا
+
+554
+00:43:18,410 --> 00:43:22,630
+اتنين مع بعض جايين غير عالما بيكونوا واحد ورا
+
+555
+00:43:22,630 --> 00:43:27,760
+التانيابنك على ممكن تقريبا أنهينا اللي هو ال
+
+556
+00:43:27,760 --> 00:43:30,660
+classification of medically important viruses وانا
+
+557
+00:43:30,660 --> 00:43:34,800
+يعني بدأ أحكي كلانتين في ختام الفصل ان هذا ال
+
+558
+00:43:34,800 --> 00:43:39,320
+chapter بالذات يحتاج مننا جهود كبيرة، من أي ناحية،
+
+559
+00:43:39,320 --> 00:43:43,260
+هو أسماء كثيرة، صفات كثيرة، وكونه classification
+
+560
+00:43:43,260 --> 00:43:47,090
+أكيد لازم يكون فيه معلوماتالشيء المطمئن في الموضوع
+
+561
+00:43:47,090 --> 00:43:53,050
+انه احنا تقريبا هندرس هذه الفيروسات بتفاصيل اكثر
+
+562
+00:43:53,050 --> 00:43:58,270
+من ذلك لكن كويس انه نوصل للتفاصيل واحنا معانا اللي
+
+563
+00:43:58,270 --> 00:44:02,170
+هو ايه؟ معانا المعلومات الأساسية و الرئيسية عن هذه
+
+564
+00:44:02,170 --> 00:44:05,870
+الفيروسات ونتمنى لكم التوفيق ان شاء الله ونكمل
+
+565
+00:44:05,870 --> 00:44:06,470
+المرة القادمة
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/AmzGBCqSgus.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/AmzGBCqSgus.srt
new file mode 100644
index 0000000000000000000000000000000000000000..434e12146d51d3aa8e82a696809ec66b51295773
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/AmzGBCqSgus.srt
@@ -0,0 +1,2015 @@
+1
+00:00:21,260 --> 00:00:23,980
+طيب بسم الله الرحمن الرحيم الحمد لله رب العالمين و
+
+2
+00:00:23,980 --> 00:00:27,300
+الصلاة والسلام على سيدنا محمد وعلى آله وصحبه ومن 
+
+3
+00:00:27,300 --> 00:00:30,640
+ساعدهم إلى يوم الدين وبعد موضوع جديد اليوم إن شاء 
+
+4
+00:00:30,640 --> 00:00:34,100
+الله اللي هو DNA non-enveloped viruses واحنا 
+
+5
+00:00:34,100 --> 00:00:37,340
+اتفقنا من البداية أن الviruses could be
+
+6
+00:00:37,340 --> 00:00:41,560
+classified based on their nuclear material into
+
+7
+00:00:41,560 --> 00:00:46,690
+DNA viruses وRNA viruses.  الدي إن إيه فيروس كانت إنفلوب
+
+8
+00:00:46,690 --> 00:00:52,370
+و لون إنفلوب درسنا في الـ إنفلوب ثلاث مجموعات أو على 
+
+9
+00:00:52,370 --> 00:00:55,530
+الأقل طبقنا في ثلاث مجموعات المجموعة الأولى هي ال
+
+10
+00:00:55,530 --> 00:00:58,390
+herpes viruses المجموعة الثانية كانت المفروض أن تكون
+
+11
+00:00:58,390 --> 00:01:02,950
+the box viruses والثالثة كانت الهيبادنة فيروس و
+
+12
+00:01:02,950 --> 00:01:07,280
+الهيبادنة لم نتطرق لها بتفاصيل لأننا كنا هنجرسها إن 
+
+13
+00:01:07,280 --> 00:01:11,760
+شاء الله من مجموعة الهيباتيتس فيروس. اليوم هنتحدث
+
+14
+00:01:11,760 --> 00:01:16,480
+بإذن الله عن الـ DNA non-enveloped viruses وهي أيضاً
+
+15
+00:01:16,480 --> 00:01:23,680
+مجموعة مكونة من ثلاثة وهي جدول صغير يلخص معظم 
+
+16
+00:01:23,680 --> 00:01:27,920
+الأشياء المهمة في هذه المجموعة.
+
+17
+00:01:30,350 --> 00:01:34,350
+العمود الأول هو الـ adenoviruses, human papilloma
+
+18
+00:01:34,350 --> 00:01:40,370
+viruses, و الـ parvo virus B19. لو نظرنا على العمود 
+
+19
+00:01:40,370 --> 00:01:43,740
+الثاني هلاقي الـ mode of transmission الـ
+
+20
+00:01:43,740 --> 00:01:46,940
+Adenovirus هناك أكثر من طريقة انتقال مثل الـ
+
+21
+00:01:46,940 --> 00:01:52,120
+Respiratory Route, الـ Fecal Oral Route, والـ Direct
+
+22
+00:01:52,120 --> 00:01:55,540
+Contact يعني بالاتصال المباشر بينما الـ Human
+
+23
+00:01:55,540 --> 00:01:59,480
+Papilloma Viruses فقط طريقتين اللي هم الـ Sexual و
+
+24
+00:01:59,480 --> 00:02:04,980
+Skin Contact. والـ Parvo Virus B19 طريقتين أيضاً
+
+25
+00:02:04,980 --> 00:02:08,660
+واحدة منهم الـ Transplacental والتانية Respiratory.
+
+26
+00:02:08,660 --> 00:02:15,280
+العمود الثالث هل هناك different strains that can
+
+27
+00:02:15,280 --> 00:02:19,800
+cause different diseases؟ يعني من هذا الصنف من ال
+
+28
+00:02:19,800 --> 00:02:23,260
+adenovirus على سبيل المثال usual أصناف بتسبب أمراض
+
+29
+00:02:23,260 --> 00:02:27,760
+مختلفة. نعم في الـ adenovirus, نعم وفي الـ human
+
+30
+00:02:27,760 --> 00:02:32,400
+papilloma virus, نعم. لكن في الـ parvo virus B19, it 
+
+31
+00:02:32,400 --> 00:02:35,760
+is only one strain, it is only one disease. تمام.
+
+32
+00:02:35,760 --> 00:02:42,470
+مافيش أمراض مختلفة. الآن أقول الرابع هل تسبب هذه
+
+33
+00:02:42,470 --> 00:02:48,390
+الأنواع أو بعضها منها سرطانات؟ في الـ adenovirus, نعم
+
+34
+00:02:48,390 --> 00:02:53,990
+لكن إجابة مشروطة في الحيوانات فقط. بينما في ال
+
+35
+00:02:53,990 --> 00:02:58,190
+human papilloma virus, نعم تسبب سرطان في الإنسان
+
+36
+00:02:58,190 --> 00:03:03,950
+والأخير هو الـ parvo virus B19 لا يسبب أي نوع من 
+
+37
+00:03:03,950 --> 00:03:10,360
+السرطان. الأخير أو العمود الأخير هل هناك vaccine
+
+38
+00:03:10,360 --> 00:03:16,620
+متاح لهذه الفيروسات؟ الأول نعم لكن ليس للمدنيين ولم
+
+39
+00:03:16,620 --> 00:03:22,640
+لمين؟ للعسكر للجيوش. الـ human papillomavirus إيش
+
+40
+00:03:22,640 --> 00:03:27,780
+الإجابة اللي مكتوبة هنا no لأ هي مش no هي yes بدنا
+
+41
+00:03:27,780 --> 00:03:32,800
+نشطبها ونكتب إيش الآن؟ yes وهنقول كل إيش جاله no
+
+42
+00:03:32,800 --> 00:03:38,780
+وهنقول إيش جاله yes تمام. الـ parvo virus B19 برضه
+
+43
+00:03:38,780 --> 00:03:42,640
+مافيش له فيروس فاكسين. إذا هذا الجدول البسيط
+
+44
+00:03:42,640 --> 00:03:47,000
+يلخص لنا الحالة للفيروسات الثلاثة اللي احنا تحدثنا
+
+45
+00:03:47,000 --> 00:03:51,760
+فيها تحت عنوان الـ DNA Non-Enveloped Virus. ال
+
+46
+00:03:51,760 --> 00:03:56,020
+adenovirus هو الأشهر على الإطلاق والأكثرها شيوعاً
+
+47
+00:03:56,020 --> 00:04:01,790
+ويمكن الأكثرها أيضاً انتشاراً وإحداثاً للأمراض. هذا
+
+48
+00:04:01,790 --> 00:04:05,450
+الشكل الجميل لهذا الفيروس لابد أن نتذكره جيداً
+
+49
+00:04:05,450 --> 00:04:09,790
+عندما نرى هذا الشكل للفيروس أو أي فيروس بهذا الشكل
+
+50
+00:04:09,790 --> 00:04:14,650
+هو الـ adenovirus. لماذا هو الوحيد الذي يمتلك ال
+
+51
+00:04:14,650 --> 00:04:18,210
+fibers اللي أنتم شايفينها اللي طالعة من
+
+52
+00:04:18,210 --> 00:04:23,270
+التقاء المثلثات في الـ icosahedral capsid تاعت
+
+53
+00:04:23,270 --> 00:04:27,710
+الـ icosahedral capsid عبارة عن أن هي مثلثات الزوايا 
+
+54
+00:04:27,710 --> 00:04:31,660
+اللي فيها التقاء المثلثات بيسموها الـ vertices. من كل
+
+55
+00:04:31,660 --> 00:04:36,800
+الـ vertices الموجودة في الفيروس تظهر الـ fiber. وهذا
+
+56
+00:04:36,800 --> 00:04:41,400
+الـ fiber له أهمية كبيرة. غير الشكل اللي نراه له أهمية
+
+57
+00:04:41,400 --> 00:04:45,100
+كبيرة في دورة حياة الفيروس. في الـ Antigenic
+
+58
+00:04:45,100 --> 00:04:48,780
+Variation للفيروس سنعرف أن الفيروس فيه 41
+
+59
+00:04:48,780 --> 00:04:54,480
+serotypes. الـ 41 serotypes مبنيين على هذا الـ fiber
+
+60
+00:04:54,480 --> 00:04:57,550
+اللي نتكلم عنه اللي هي الخيوط اللي موجودة هنا. أيضاً
+
+61
+00:04:57,550 --> 00:05:01,170
+هلاقي أن الفيروس من صفاته أنه بيعمل hemagglutination
+
+62
+00:05:01,170 --> 00:05:05,790
+يعني بيجمع Red Blood Cell. عارفين مين المسؤول عن
+
+63
+00:05:05,790 --> 00:05:09,850
+hemagglutination؟ برضه اللي هو الـ fiber protein
+
+64
+00:05:09,850 --> 00:05:13,290
+اللي موجود على هذا الفيروس. إذا ليس فقط الشكل
+
+65
+00:05:13,290 --> 00:05:19,000
+وإنما له دور كبير في الوظيفة. فاحنا قلنا إن هو الأهم من
+
+66
+00:05:19,000 --> 00:05:22,880
+المجموعة اللي معانا الـ adenovirus. لماذا؟ لماذا
+
+67
+00:05:22,880 --> 00:05:27,780
+هو الأهم؟ انظروا إلى اللوحة وفلنراجع معاً أسماء
+
+68
+00:05:27,780 --> 00:05:33,310
+الأمراض اللي بسببها هذا الـ virus. فرنجايتس مين بيسبب
+
+69
+00:05:33,310 --> 00:05:37,850
+bacterial pharyngitis؟ Streptococcus pyogenes
+
+70
+00:05:37,850 --> 00:05:40,990
+Streptococcus pyogenes هي الأشهر في البكتيريا. ال
+
+71
+00:05:40,990 --> 00:05:44,130
+adenovirus هو الأشهر على الإطلاق في الـ viruses في
+
+72
+00:05:44,130 --> 00:05:48,210
+إحداث الـ pharyngitis بل و هناك بعض المراجع تقول
+
+73
+00:05:48,210 --> 00:05:52,670
+أن نسبة إصابة الأطفال بالـ adenovirus pharyngitis
+
+74
+00:05:52,670 --> 00:05:55,050
+أكثر من نسبة إصابة الأطفال بالـ bacterial
+
+75
+00:05:55,050 --> 00:05:59,390
+pharyngitis. لذلك لما كانوا يقولوا لكم أنّه مش كل
+
+76
+00:05:59,390 --> 00:06:04,570
+التهاب حلق بيحتاج antibiotic هي مقولة صحيحة أنّه قد
+
+77
+00:06:04,570 --> 00:06:08,730
+يكون adenovirus. كونجنكتيفايتس التهاب ملتحمة مثل عين
+
+78
+00:06:08,730 --> 00:06:15,370
+الـ common cold. وهو ناقف هل هو المسبب أو عدوى فيروس؟ 
+
+79
+00:06:15,370 --> 00:06:19,530
+هو المسبب الوحيد للـ common cold؟ لأ ولا المسبب
+
+80
+00:06:19,530 --> 00:06:23,730
+الرئيسي؟ المسبب الرئيسي للـ common cold هو الـ rhino
+
+81
+00:06:23,730 --> 00:06:32,120
+virus. هو أيضاً يسبب أعراض الـ common cold. نيمونيا
+
+82
+00:06:32,120 --> 00:06:37,020
+كيراتو كونجنكتيفايتس hemorrhagic cystitis وكلمة
+
+83
+00:06:37,020 --> 00:06:41,800
+hemorrhagic cystitis يعني التهاب المثانة النزفي.
+
+84
+00:06:41,800 --> 00:06:49,880
+يعني بيكون فيه دم في البول. بيكون كمان قلة في إدرار
+
+85
+00:06:49,880 --> 00:06:53,240
+البول يعني ممكن يكون dysuria حتى ما فيش بول خالص.
+
+86
+00:06:53,240 --> 00:06:57,340
+يعني يصير وينزل فقط blood. keratoconjunctivitis
+
+87
+00:06:57,340 --> 00:07:01,750
+التهاب القرنية والتهاب ملتحمة العين. ال
+
+88
+00:07:01,750 --> 00:07:06,810
+Gastroenteritis، شوفوا الآن التنوع في الأمراض من
+
+89
+00:07:06,810 --> 00:07:10,330
+الـ Upper Respiratory Tract إلى الـ Cystitis إلى
+
+90
+00:07:10,330 --> 00:07:15,170
+Gastroenteritis إلى Eye Infection، وهذا بيأكد على
+
+91
+00:07:15,170 --> 00:07:19,270
+ما ذكرناه سابقاً من طرق انتقال الفيروس، اللي هي
+
+92
+00:07:19,270 --> 00:07:24,170
+الثلاثة. Some viruses من الـ Adenoviruses can
+
+93
+00:07:24,170 --> 00:07:26,930
+cause sarcomas in rodents.
+
+94
+00:07:29,780 --> 00:07:36,360
+لكن ليس في الإنسان. من الخصائص المهمة لهذا الفيروس
+
+95
+00:07:36,360 --> 00:07:41,300
+أنها non-enveloped double-stranded linear DNA
+
+96
+00:07:41,300 --> 00:07:45,680
+المهم أن نركز على كلمة linear DNA لأن الفيروس اللي
+
+97
+00:07:45,680 --> 00:07:48,680
+بعده هلاقي فيه circular DNA
+
+98
+00:07:50,980 --> 00:07:54,660
+الكبسيد هي إيكوزاهيدر. الكبسيد و they are the only
+
+99
+00:07:54,660 --> 00:08:00,180
+viruses with a fiber protruding
+
+100
+00:08:00,180 --> 00:08:04,600
+تخرج من each of the twelve vertices of the capsid.
+
+101
+00:08:10,420 --> 00:08:13,960
+إيش وظيفة الـ Fiber؟ It is the organ of attachment
+
+102
+00:08:13,960 --> 00:08:19,260
+يعني خلايانا اللي بتنصاها هي الـ Receptor أو عليها 
+
+103
+00:08:19,260 --> 00:08:24,940
+Receptor لهذا الـ Fiber and it functions as a
+
+104
+00:08:24,940 --> 00:08:27,460
+hemagglutinin. وكلكم عارفين إيش يعني Hemagglutinin.
+
+105
+00:08:27,460 --> 00:08:31,820
+لذلك هنلاقي إنّه ضمن الـ diagnostic test
+
+106
+00:08:31,820 --> 00:08:36,780
+Hemagglutination Inhibition Assay يعني ممكن نكشف
+
+107
+00:08:36,780 --> 00:08:42,930
+عالمه من خلال هذه الطريقة أو الفكرة. مش بس كمان ال
+
+108
+00:08:42,930 --> 00:08:47,470
+.. ال .. الـ fiber بيشتغل hemagglutinin وبيشتغل
+
+109
+00:08:47,470 --> 00:08:51,710
+الارتباط. لو احنا جسنا من الفيروس، يعني اتخلصنا من
+
+110
+00:08:51,710 --> 00:08:54,870
+كل شيء من الفيروس وفقط طلعنا الـ fibers هذه و
+
+111
+00:08:54,870 --> 00:08:58,270
+حقنها في الخلايا، هلاقي أن الخلايا بتموت، ما تحكي 
+
+112
+00:08:58,270 --> 00:09:05,230
+أنّه toxic أو cytotoxic to the cells. هناك 41 سيرو
+
+113
+00:09:05,230 --> 00:09:10,470
+تايب معروفين للأدينو فيروس وهذا التغير في الـ sero
+
+114
+00:09:10,470 --> 00:09:15,510
+تايب مبني على التغير في الـ fiber. كمان مرة fiber 
+
+115
+00:09:15,510 --> 00:09:19,850
+بروتين وهو type specific. إيش type specific؟ يعني
+
+116
+00:09:19,850 --> 00:09:26,210
+لو الفيروس X واحد من الـ 41 دخل جسم الإنسان باسم
+
+117
+00:09:26,210 --> 00:09:30,490
+الإنسان بيكوّله مناعة. هذه مناعة specific لفقط
+
+118
+00:09:30,490 --> 00:09:35,790
+strain واحد. لو دخل اثنين لازم يكوّله مناعة مرة أخرى.
+
+119
+00:09:35,790 --> 00:09:41,810
+لكن الشيء المطمئن في هذا الفيروس أنّه fifty percent
+
+120
+00:09:41,810 --> 00:09:45,690
+من الـ infections are asymptomatic. خمسين بالمائة
+
+121
+00:09:45,690 --> 00:09:52,800
+asymptomatic. ومعظم بل نقول جل تمام الأمراض اللي
+
+122
+00:09:52,800 --> 00:09:57,260
+بتسببها هذا الـ virus can resolve spontaneously،
+
+123
+00:09:57,260 --> 00:10:00,020
+إيش يعني resolve spontaneously؟ يعني بطبيعة حالته
+
+124
+00:10:00,020 --> 00:10:04,180
+الشفاء تلقائياً بدون علاج. لذلك على فكرة ما فيش
+
+125
+00:10:04,180 --> 00:10:09,400
+antiviral لهذا الـ disease. في vaccine لكن زي ما 
+
+126
+00:10:09,400 --> 00:10:13,440
+أحكيلكوا، vaccine لمين؟ للملتاري، للملتاري
+
+127
+00:10:16,170 --> 00:10:20,110
+في شغل ممكن في المستقبل يعني تساهم في إنتاج
+
+128
+00:10:20,110 --> 00:10:25,330
+vaccine لكن لحد الآن هذا الـ group specific antigen
+
+129
+00:10:25,330 --> 00:10:27,930
+كلمة group specific يعني هذا common لكل الـ
+
+130
+00:10:27,930 --> 00:10:32,310
+adenovirus يعني يفترض إيش يا بنات؟ يفترض إنه لو
+
+131
+00:10:32,310 --> 00:10:37,410
+أنا قدرت أخد هذا الـ antigen تمام؟ و أعمله ك
+
+132
+00:10:37,410 --> 00:10:42,520
+vaccine الـ vaccine هذا يوفر لي حماية من مين؟ من كل
+
+133
+00:10:42,520 --> 00:10:46,640
+الـ adenovirus لكن للأسف ما بصير، عارفين ليش؟ لأن
+
+134
+00:10:46,640 --> 00:10:51,440
+هو أصلا مش على الأطراف هذا الـ common antigen
+
+135
+00:10:51,440 --> 00:10:56,680
+والنمو الموجود داخل اللي هو الـ capsid نفسها، فداخل
+
+136
+00:10:56,680 --> 00:11:01,220
+الـ capsid الفيروس عشان يصير له neutralization،
+
+137
+00:11:01,220 --> 00:11:05,990
+لازم الـ antibody وين يرتبط؟ على الـ fibers يبقى لو
+
+138
+00:11:05,990 --> 00:11:11,130
+قدرت أنا الاقي antigen common في المنطقة هذه في
+
+139
+00:11:11,130 --> 00:11:15,250
+منطقة الـ fibers تمام ممكن اصنع بالفعل vaccine يكون
+
+140
+00:11:15,250 --> 00:11:18,850
+مناسب للواحد واربعين لكن في هذه اللحظة و لحد هذه
+
+141
+00:11:18,850 --> 00:11:23,470
+اللحظة لم نستطيع الحصول على vaccine موحد لهذا الـ
+
+142
+00:11:23,470 --> 00:11:29,830
+virus طيب في كمان شئ المهم كمان ان في ارتباط بين
+
+143
+00:11:29,830 --> 00:11:34,750
+الـ serotype و بين الـ diseaseيعني مش كل الـ
+
+144
+00:11:34,750 --> 00:11:39,890
+Serotype بيسببوا نفس المرض وانما هناك Serotype
+
+145
+00:11:39,890 --> 00:11:45,730
+متخصصة مثلا بيقولنا انه 12 و 18 و 31 عملوا
+
+146
+00:11:45,730 --> 00:11:50,150
+Sarcomas في الـ hamsters بتاع في الـ hamsters اللي هم
+
+147
+00:11:50,150 --> 00:11:53,730
+الحيوان هذا اللي صورته موجودة أمامكم هذا اسمه
+
+148
+00:11:53,730 --> 00:11:57,350
+hamster وهو حيوان تجارب وعارفين كيف تكون الـ
+
+149
+00:11:57,350 --> 00:12:01,330
+sarcomas تكونت الـ sarcomas at the site of
+
+150
+00:12:01,330 --> 00:12:04,010
+injection يعني في المكان اللي احنا فيه حقاننا
+
+151
+00:12:04,010 --> 00:12:09,650
+الفيروس في الفقر تكون sarcomas لكن لم يحدث هذا
+
+152
+00:12:09,650 --> 00:12:13,970
+الكلام في الإنسان ماذا استفدنا من اللوحة هذه؟
+
+153
+00:12:13,970 --> 00:12:18,490
+استفدنا إنه في common group specific antigen ثاناء
+
+154
+00:12:18,490 --> 00:12:23,150
+في اندي specific serotype causes specific symptoms
+
+155
+00:12:23,150 --> 00:12:26,130
+وحنشوف كمان شوية تفاصيل أكثر عن هذا الكلام
+
+156
+00:12:26,130 --> 00:12:29,330
+الأنينوفاياسيز
+
+157
+00:12:29,330 --> 00:12:33,370
+are transmitted usually by aerosols droplets عبر
+
+158
+00:12:33,370 --> 00:12:39,730
+الرذاذ from oral route من البراز إلى الفم وهذه
+
+159
+00:12:39,730 --> 00:12:44,240
+غالبا بتكون common في من؟ في الـ children ليش common
+
+160
+00:12:44,240 --> 00:12:50,740
+في الـ children يا بنات؟ مش بس موضوع النظافة في
+
+161
+00:12:50,740 --> 00:12:54,540
+فترة من الأعمار من عمر الأطفال بتعرفوا على الأشياء
+
+162
+00:12:54,540 --> 00:12:58,680
+من خلال التذوق يا لو أعطناه مفتاح سوف يضعه في فمه
+
+163
+00:12:58,680 --> 00:13:04,060
+لو أعطناه أي أداء جلم أي حاجة يضعها في الفم الآن
+
+164
+00:13:04,060 --> 00:13:09,780
+هذا الـ practice بالإضافة إلى عدم الوعي في موضوع
+
+165
+00:13:09,780 --> 00:13:15,260
+النظافة الشخصية يزيد من احتمالية نقل الأمراض عبر
+
+166
+00:13:15,260 --> 00:13:18,540
+الفكرة الـoral route مش بس لهم، للأطفال و كمان
+
+167
+00:13:18,540 --> 00:13:21,380
+للبالغين في نفس الأسرة، يعني وين فيه أطفال، فيه
+
+168
+00:13:21,380 --> 00:13:26,200
+احتمالية انتقال أيضًا للأهل من خلال هذه الـ route
+
+169
+00:13:26,200 --> 00:13:30,380
+Direct Inculation، إيش يعني Direct Inculation؟
+
+170
+00:13:30,380 --> 00:13:34,860
+يعني حق مباشر of conjunctivas by tonometers or
+
+171
+00:13:34,860 --> 00:13:38,320
+fingers أنا دايما بقولكوا الفينجر هذا أداة مهمة
+
+172
+00:13:38,320 --> 00:13:43,800
+جدا في نقل من العدوى خاصة في العين finger to eye
+
+173
+00:13:43,800 --> 00:13:47,640
+root بس في طريقة تانية اللي هي من خلال الـ
+
+174
+00:13:47,640 --> 00:13:51,880
+tonometers شايفين الصورة هذه؟ الصورة هذه هي عبارة
+
+175
+00:13:51,880 --> 00:13:56,220
+عن جهاز صغير بينجيس فيه ضغط العين إذا الـ
+
+176
+00:13:56,220 --> 00:14:01,240
+Tonometer هو جهاز لقياس ضغط العين كيف يشتغل هذا
+
+177
+00:14:01,240 --> 00:14:07,420
+الجهاز بيحط الجهاز على القرانية و بيدغط ضغط خفيفة
+
+178
+00:14:07,420 --> 00:14:11,900
+الآن القرانية أو العين بشكل عام هتعمل ضغط إلى
+
+179
+00:14:11,900 --> 00:14:18,370
+اتجاه المعاكس فبيجيسه الضغط من خلال Exergen لا
+
+180
+00:14:18,370 --> 00:14:23,690
+pressure ومن ثم قياس الضغط المعاكس يبقى فيه تلامس
+
+181
+00:14:23,690 --> 00:14:28,610
+ما بين الجهاز وما بين العين إذا هذا الجهاز لم يعقم
+
+182
+00:14:28,610 --> 00:14:36,710
+بين مريض و آخر فسوف يكون أداة لنقل منه العدوى وهذا
+
+183
+00:14:36,710 --> 00:14:40,090
+النوع من العدوى ما نسميه في الطب هي atrogenic
+
+184
+00:14:40,090 --> 00:14:45,330
+infection iatrogenic يعني نقلت من خلال التداوي، من
+
+185
+00:14:45,330 --> 00:14:50,730
+خلال الفحص، من خلال أدوات الأطباء أو ممارسات اللي
+
+186
+00:14:50,730 --> 00:14:54,910
+هم الأطباء في المستشفيات، إيش اسمها؟ iatrogenic،
+
+187
+00:14:54,910 --> 00:14:59,910
+هتمروا معانا بتحيل المصطلح كمان شوية حكينا عن
+
+188
+00:14:59,910 --> 00:15:02,690
+الفكرة All are root common in young children and
+
+189
+00:15:02,690 --> 00:15:06,710
+their families. Many species of animals are
+
+190
+00:15:06,710 --> 00:15:09,490
+infected by strains of adenovirus but these
+
+191
+00:15:09,490 --> 00:15:12,870
+strains are not pathogenic to human يعني الإنسان
+
+192
+00:15:12,870 --> 00:15:19,210
+والحيوان اللي هم سردات مختلفة من هذا الـ virus ممكن
+
+193
+00:15:19,210 --> 00:15:23,890
+الـ adenovirus يعمل epidemic أو outbreaks على الرغم
+
+194
+00:15:23,890 --> 00:15:29,630
+من أننا نوصفه على أنه endemic إيش يعني endemic؟
+
+195
+00:15:29,630 --> 00:15:33,850
+endemic يعني مستوطن يعني موجود worldwide في كل
+
+196
+00:15:33,850 --> 00:15:38,600
+العالم في adenovirus لكن قد يحدث أن يكون فيه
+
+197
+00:15:38,600 --> 00:15:43,880
+outbreaks مثال على فئة مهمة بيحدث فيها outbreaks
+
+198
+00:15:43,880 --> 00:15:47,360
+اللي هم الـ military recruits الـ military recruits
+
+199
+00:15:47,360 --> 00:15:53,300
+اللي هم مين؟ المجندين الجدد طبعا في ناس زي
+
+200
+00:15:53,300 --> 00:15:57,020
+المجندين الجدد بيسموهم college students اللي هم
+
+201
+00:15:57,020 --> 00:16:02,040
+طلاب الجامعة طلاب الجامعة ليش الـ military recruits
+
+202
+00:16:02,040 --> 00:16:07,240
+و طلاب الجامعات بالذات عندهم قابلية للانتشار فيه
+
+203
+00:16:07,240 --> 00:16:12,180
+أو انتشار الأمراض بشكل كبير؟ في معظم الدول .. في
+
+204
+00:16:12,180 --> 00:16:17,700
+معظم الدول التجنيد بيكون مركزي بمعنى أنه بييجي من
+
+205
+00:16:17,700 --> 00:16:23,380
+القرى و من المدن الأشخاص على مكان بعيد الآن بيئة
+
+206
+00:16:23,380 --> 00:16:26,760
+جديدة انتقال من بيئة الـ home اللي هو البيت اللي هي
+
+207
+00:16:26,760 --> 00:16:30,720
+الأم والأب و الـ family و الأصدقاء إلى بيئة جديدة
+
+208
+00:16:30,720 --> 00:16:35,460
+ما بيعرفوا حالة فيها غالبا بيئة غريبة عليهم طريقة
+
+209
+00:16:35,460 --> 00:16:40,300
+التناول أطعمها مختلفة الغذاء بتغير بيقدم لهم أغذية
+
+210
+00:16:40,300 --> 00:16:43,630
+غير اللي كانوا ياخدوها في البيتفبكونوا under
+
+211
+00:16:43,630 --> 00:16:49,090
+stress متوترين التغذية تبعتهم مش تمام كويس home
+
+212
+00:16:49,090 --> 00:16:55,970
+sick شعرين بالحنين الى الاهل و المكان و في نفس
+
+213
+00:16:55,970 --> 00:17:02,130
+الوجد they are enclosed يعني in crowded conditions
+
+214
+00:17:02,130 --> 00:17:08,510
+يعني ظروف من الازدحام من الازدحام فانت ما نعم خافي
+
+215
+00:17:08,510 --> 00:17:12,890
+ضرر ننتج عن الأسباب اللي ذكرتها بالإضافة إلى أنهم
+
+216
+00:17:12,890 --> 00:17:16,670
+أصلًا crowded و بالتالي امكانية الانتقال بينهم بتكون
+
+217
+00:17:16,670 --> 00:17:20,430
+إمكانية عالية هذا الكلام بيتطبق على مين؟ على
+
+218
+00:17:20,430 --> 00:17:25,110
+الجنود و طلاب الجامعة نفس القصة احنا محظوظين إنه
+
+219
+00:17:25,110 --> 00:17:28,890
+جامعاتنا جامنة تمام؟ سواء حتى لو كنا في رفح أو في
+
+220
+00:17:28,890 --> 00:17:32,870
+بيت حنون لكن بالنسبة إن الجامعة قريبة جدا بالنسبة
+
+221
+00:17:32,870 --> 00:17:37,230
+لما كان ساكن في معظم الدول التانية بيسافر من ولاية
+
+222
+00:17:37,230 --> 00:17:40,730
+لولاية أو من مدينة إلى مدينة حتى يذهب إلى الجامعة
+
+223
+00:17:40,730 --> 00:17:45,030
+وبالتالي برضه بيكون بينطبق عليه ما ينطبق على الـ
+
+224
+00:17:45,030 --> 00:17:47,630
+military recruit اللي احنا ذكرناهم قبل قليل
+
+225
+00:17:52,340 --> 00:17:56,340
+زي ما ذكرت أنا إنه certain types are associated
+
+226
+00:17:56,340 --> 00:18:00,700
+with specific syndrome مثلا والأرقام اللي مذكورة
+
+227
+00:18:00,700 --> 00:18:04,780
+هنا مش للحفظ وإنما هي للتمثيل وهي أرقام حقيقية
+
+228
+00:18:04,780 --> 00:18:08,280
+حقيقة لكن مش هان .. يعني نطلب منكم تحفظوهم
+
+229
+00:18:08,280 --> 00:18:13,320
+للاختبار تلاتة أربعة سبعة واحد وعشرين مربوطين بمين
+
+230
+00:18:13,320 --> 00:18:16,660
+بالـ respiratory disease احفظوهم كويس هدول الاربعة
+
+231
+00:18:16,660 --> 00:18:20,100
+الآن .. الآن احفظوهم احنا في لوحة تانية هنستفيد
+
+232
+00:18:20,100 --> 00:18:25,300
+منهم تمانية و تسعة و عشر كيراتو كوندكتفيتس أحداشر و
+
+233
+00:18:25,300 --> 00:18:28,900
+واحد و عشرين hemorrhagic cystitis أربعين و واحد و
+
+234
+00:18:28,900 --> 00:18:33,940
+أربعين بسبب infantile gastroenteritis إذا في عندي
+
+235
+00:18:33,940 --> 00:18:37,300
+سلالات بتعمل gastroenteritis سلالات بتعمل
+
+236
+00:18:37,300 --> 00:18:40,020
+hemorrhagic cystitis سلالات بتعمل كيراتو
+
+237
+00:18:40,020 --> 00:18:43,600
+كوندكتفيتس و بتعمل في الأخر اللي هو الأول واحدة الـ
+
+238
+00:18:43,600 --> 00:18:48,980
+respiratory disease طبعا لحظة especially in من
+
+239
+00:19:05,710 --> 00:19:10,510
+Pathogenesis و الإميونية الانينوفيروس انفكت
+
+240
+00:19:10,510 --> 00:19:17,380
+الميكوزل ابيثيليا معفن من عدة أعضاء كثير لكن الـ
+
+241
+00:19:17,380 --> 00:19:20,760
+target المستدف هو مين؟ الـ epithelial تبع هذه
+
+242
+00:19:20,760 --> 00:19:23,540
+الأورجان زي الـ respiratory tract و الـ
+
+243
+00:19:23,540 --> 00:19:26,080
+gastrointestinal tract زائد اللي هو الـ
+
+244
+00:19:26,080 --> 00:19:31,580
+conjunctivus المناعة مرتبطة بـ neutralizing
+
+245
+00:19:31,580 --> 00:19:34,720
+antibody و ماذا يقصد neutralizing antibody يا بنات؟
+
+246
+00:19:34,720 --> 00:19:38,140
+هو الـ antibody اللي هيرتبط بالـ binding site، مين
+
+247
+00:19:38,140 --> 00:19:40,400
+الـ binding site في هذه الحالة؟ اللي هو الـ fibers
+
+248
+00:19:40,400 --> 00:19:45,780
+اللي احنا شفناه في أول المحارة and it is type
+
+249
+00:19:45,780 --> 00:19:52,000
+specific and life long يعني بيعطينا حماية لمدى
+
+250
+00:19:52,000 --> 00:19:56,940
+الحياة، مدى الحياة In addition to acute infection
+
+251
+00:19:56,940 --> 00:20:00,540
+leading to death of cells, adenovirus causes
+
+252
+00:20:00,540 --> 00:20:07,720
+latent infection. إذن ليس herpes viruses 
+
+253
+00:20:07,720 --> 00:20:12,400
+وحدها اللي بتعمل latent infection، أيضا adenovirus
+
+254
+00:20:12,400 --> 00:20:16,250
+بتعمل latent infection، وين بيعمل
+
+255
+00:20:16,250 --> 00:20:19,690
+latency؟ في الـTonsillar tissue عشان هيك ممكن يصير
+
+256
+00:20:19,690 --> 00:20:23,410
+فينا repeated infection في الـTonsils وفي
+
+257
+00:20:23,410 --> 00:20:29,750
+الـAdenoid tissue والحقيقة أن الفيروس عُزل لأول مرة
+
+258
+00:20:29,750 --> 00:20:35,950
+في العام 1953 من Adenoids من غدة لمفاوية في جسم
+
+259
+00:20:35,950 --> 00:20:40,870
+الإنسان، وسمي Adenovirus لإنه عُزل من هذه
+
+260
+00:20:40,870 --> 00:20:43,530
+الـAdenoid cells أو الـAdenoid tissue.
+
+261
+00:20:46,710 --> 00:20:49,530
+من الـclinical findings للأمراض اللي احنا شفناها
+
+262
+00:20:49,530 --> 00:20:52,430
+قبل قليل، مثلا في الـupper respiratory tract
+
+263
+00:20:52,430 --> 00:20:57,390
+infection، ممكن نلاقي pharyngitis التهاب في الحلق،
+
+264
+00:20:57,390 --> 00:21:01,610
+pharyngoconjunctivitis أو pharyngoconjunctival fever
+
+265
+00:21:01,610 --> 00:21:07,710
+هم مصحوبة بالتهاب في الـpharynx يعني الـ
+
+266
+00:21:07,710 --> 00:21:12,670
+pharyngitis، بالإضافة إلى احمرار العين، and acute
+
+267
+00:21:12,670 --> 00:21:17,230
+respiratory disease. كلمة acute يعني الأعراض بتكون
+
+268
+00:21:17,230 --> 00:21:20,490
+prominent وواضحة، و الـonset بتكون rapid
+
+269
+00:21:20,490 --> 00:21:24,510
+characterized by fever, sore throat, coryza،
+
+270
+00:21:24,510 --> 00:21:28,230
+coryza معناها runny nose يعني الأنف بيكون بيسيل
+
+271
+00:21:28,230 --> 00:21:33,770
+تسيل من الأنف، and conjunctivitis في الـlower
+
+272
+00:21:33,770 --> 00:21:37,830
+respiratory tract فينا two conditions: bronchitis
+
+273
+00:21:37,830 --> 00:21:41,130
+and atypical pneumonia. وكلّكم بتعرفوا pneumonia
+
+274
+00:21:41,130 --> 00:21:46,370
+معناها ذات الرئة، ليش حطينا جملة atypical عشان
+
+275
+00:21:46,370 --> 00:21:49,790
+نميزها عن الـpneumonia caused by common بكتير زي
+
+276
+00:21:49,790 --> 00:21:53,710
+Streptococcus pneumoniae. وكلمة atypical pneumonia لا
+
+277
+00:21:53,710 --> 00:21:58,290
+تعني أن أنا بس بتكلم عن الـadenovirus، هناك مجموعة
+
+278
+00:21:58,290 --> 00:22:01,950
+كبيرة من الميكروبات اللي يمكن تسبب atypical
+
+279
+00:22:01,950 --> 00:22:05,670
+pneumonia، hematuria، and dysuria.
+
+280
+00:22:10,220 --> 00:22:14,560
+العرضين المهمين والبارزين في الـhemorrhagic cystitis
+
+281
+00:22:14,560 --> 00:22:15,920
+في الـhemorrhagic cystitis في الـhemorrhagic cystitis
+
+282
+00:22:15,920 --> 00:22:21,220
+طبعا في الـgastroenteritis غالبا بتكون non-bloody
+
+283
+00:22:21,220 --> 00:22:21,920
+diarrhea.
+
+284
+00:22:26,400 --> 00:22:29,200
+diarrhea في الأطفال اللي بنقسمها، أو diarrhea بشكل عام
+
+285
+00:22:29,200 --> 00:22:33,660
+بنقسمها لقسمين: bloody لما تكون مصحوبة بدم، و non-
+
+286
+00:22:33,660 --> 00:22:37,700
+bloody. فهذا التصنيف فقط لوجود الدم أو عدم وجود
+
+287
+00:22:37,700 --> 00:22:41,820
+الدم، لأن في consequences لوجود الدم أو عدم وجود
+
+288
+00:22:41,820 --> 00:22:45,100
+الدم. فإذا bloody diarrhea و non-bloody diarrhea، إذا
+
+289
+00:22:45,100 --> 00:22:49,540
+هذه الـadenovirus مش بيعمل non-bloody diarrhea لمن؟
+
+290
+00:22:49,540 --> 00:22:53,700
+للأطفال اللي عمرهم كده أقل من سنتين، إيش بنسميهم
+
+291
+00:22:53,700 --> 00:22:56,850
+الأطفال اللي عمرهم أقل من سنتين؟ Infants اللي هم
+
+292
+00:22:56,850 --> 00:23:01,630
+الرضع، تمام؟ اللي هنا بينطبق عليهم القول بأنهم هم
+
+293
+00:23:01,630 --> 00:23:05,850
+بالفعل الفئة الأكثر عرضة للفكرة الـoral من
+
+294
+00:23:05,850 --> 00:23:10,050
+الممارسات اللي هي الأطفال بيمارسوها من خلال هنا
+
+295
+00:23:10,050 --> 00:23:16,030
+بتتعرف على الأشياء من خلال التذوق. Most adenovirus
+
+296
+00:23:16,030 --> 00:23:20,890
+infections resolve spontaneously زي ما ذكرنا بتروح
+
+297
+00:23:20,890 --> 00:23:24,990
+لحالها، عددا Approximately half of the adenovirus
+
+298
+00:23:24,990 --> 00:23:32,450
+infections are asymptomatic. قد
+
+299
+00:23:32,450 --> 00:23:36,250
+تكون
+
+300
+00:23:36,250 --> 00:23:43,110
+لأسباب غير أن هو فيروس ضعيف، سأعطيكم سؤال بالإن
+
+301
+00:23:43,110 --> 00:23:47,990
+تفكروا فيه: إذا كان هناك Strain من الذين يعملوا مرض في
+
+302
+00:23:47,990 --> 00:23:52,550
+الـRespiratory tract من اللي بيعمل
+
+303
+00:23:52,550 --> 00:23:56,090
+infection للـRespiratory tract دخل إلى ال
+
+304
+00:23:56,090 --> 00:24:00,580
+Gastrointestinal tract، هل هيعمل infection أو مش 
+
+305
+00:24:00,580 --> 00:24:03,820
+هيعمل infection؟ بيعمل infection لكن مش بيعمل
+
+306
+00:24:03,820 --> 00:24:08,720
+infection symptomatic، وهذا أساس الـvaccine احنا
+
+307
+00:24:08,720 --> 00:24:13,060
+لما نعمل vaccine بنعمل vaccine للـRespiratory للـ
+
+308
+00:24:13,060 --> 00:24:18,380
+Respiratory strains بس بنعطيها عبر مين؟ عبر الفم
+
+309
+00:24:18,380 --> 00:24:20,980
+عشان تروح على الـintestine و تعمل infection
+
+310
+00:24:20,980 --> 00:24:27,570
+asymptomatic infection، إذا قد تكون fifty percent من
+
+311
+00:24:27,570 --> 00:24:33,330
+الإصابات بالـadenovirus are asymptomatic لهذا
+
+312
+00:24:33,330 --> 00:24:37,310
+السبب، وليس بسبب أن الفيروس ضعيف وغير قادر على أن
+
+313
+00:24:37,310 --> 00:24:41,870
+يعمل عدوى، أنه دخل في مكان غير محبب له فعمل
+
+314
+00:24:41,870 --> 00:24:45,710
+infection لكن هذه الـinfection كانت asymptomatic.
+
+315
+00:24:45,710 --> 00:24:52,810
+الـlab diagnosis، الحقيقة أنه... يعني قلتلكم هذا
+
+316
+00:24:52,810 --> 00:24:58,160
+الفيروس مش كتير مهتمين فيه في العالم إلا في جزئية
+
+317
+00:24:58,160 --> 00:25:00,680
+اللي هو الـmilitary recruits وعمليله vaccine، لكن
+
+318
+00:25:00,680 --> 00:25:04,520
+الـdiagnosis بتاعه ممكن يتم من خلال شغلتين
+
+319
+00:25:04,520 --> 00:25:10,080
+رئيسيتين، الأولى أن نعمل عزل للفيروس في cell
+
+320
+00:25:10,080 --> 00:25:14,480
+culture، والثانية من خلال الـserology fourfold
+
+321
+00:25:14,480 --> 00:25:20,960
+increase in antibody titer. فاكرينها الـIgG اليوم
+
+322
+00:25:20,960 --> 00:25:25,560
+وبعد عشر أيام وزيادة أربعة أضعاف أو أكثر في
+
+323
+00:25:25,560 --> 00:25:29,380
+الـTiter تعتبر Diagnostic. والفحصين المستخدمين في
+
+324
+00:25:29,380 --> 00:25:33,980
+السيرولوجيا الأكثر شيوعا هم الـComplement Fixation
+
+325
+00:25:33,980 --> 00:25:38,260
+والـHemagglutination Inhibition. بالنسبة
+
+326
+00:25:38,260 --> 00:25:44,700
+لـTreatment كما ذكرنا لكم ما فيش Antiviral Therapy
+
+327
+00:25:44,700 --> 00:25:51,650
+لهذا الفيروس. بالنسبة لـPrevention تعرف تطلع على
+
+328
+00:25:51,650 --> 00:25:55,730
+الـMode of Transmission. الـMode of Transmission
+
+329
+00:25:55,730 --> 00:26:00,810
+كيف بينتقل الفيروس؟ بينتقل عبر طريق الـfecal-oral
+
+330
+00:26:00,810 --> 00:26:06,450
+بينتقل عبر طريق اللي هو الـRespiratory وبينتقل عبر
+
+331
+00:26:06,450 --> 00:26:10,010
+iatrogenic. وين الـiatrogenic؟ هلعظني في المكان هذا؟
+
+332
+00:26:10,010 --> 00:26:16,670
+Iatrogenic، طب إذا Iatrogenic كيف بدنا نمنع انتقال
+
+333
+00:26:16,670 --> 00:26:23,000
+العدوى؟ بدنا نمارس ممارسات aseptic technique strict
+
+334
+00:26:23,000 --> 00:26:27,920
+aseptic technique لكل من يتعامل مع الـeye عشان ما
+
+335
+00:26:27,920 --> 00:26:33,440
+ننقلش الميكروب من شخص إلى شخص آخر. هذه نقطة كتير
+
+336
+00:26:33,440 --> 00:26:38,300
+مهمة. طب بالنسبة للـRespiratory نرمنا نفس الكح صعب
+
+337
+00:26:38,300 --> 00:26:42,840
+ولا لأ؟ إذا الأشخاص الأكثر عرضة احنا كنا نقول لكم
+
+338
+00:26:42,840 --> 00:26:46,920
+عنهم مين هم؟ الـmilitary recruits. إذا بنحميهم بعمل
+
+339
+00:26:46,920 --> 00:26:52,580
+vaccine. الآن الـvaccine هذا مكون من ثلاث سلالات: أربعة
+
+340
+00:26:52,580 --> 00:26:56,120
+و سبعة وجداش وواحد وعشرين، وأنا أقول لكم تذكروهم
+
+341
+00:26:56,120 --> 00:27:00,460
+من مين؟ من لوحات سابقة. طبعا خدوا بالكم في Vaccines
+
+342
+00:27:00,460 --> 00:27:05,740
+كتيرة معمولة لكن هذا هو الأشهر على الإطلاق في اللي
+
+343
+00:27:05,740 --> 00:27:09,500
+هو هذا المجال الآن. طبعا من كلامي أنا فهمت أن
+
+344
+00:27:09,500 --> 00:27:14,360
+الـvaccine بيحتوي على مين؟ على ثلاثة. أرجو منكم لا
+
+345
+00:27:14,360 --> 00:27:19,140
+تفهموا هذا الكلام، افهموا أن كل واحد منهم لحاله لما
+
+346
+00:27:19,140 --> 00:27:24,020
+حطوهم مع بعض، واحد عمل interference مع الثانيين،
+
+347
+00:27:24,020 --> 00:27:28,260
+بمعنى أن الجسم كوّن أجسام مضادة لواحد بس ما كوّنش
+
+348
+00:27:28,260 --> 00:27:32,840
+الأجسام، ما كوّنش الثانيين الباقين، فإيش نتجنا؟ أن
+
+349
+00:27:32,840 --> 00:27:37,220
+وجودهم مع بعض بيعمل interference مع بعض، وطبعا هذا
+
+350
+00:27:37,220 --> 00:27:41,550
+ممكن يكون منطقي، عارفين ليش؟ لأن الفيروس لما بيدخل
+
+351
+00:27:41,550 --> 00:27:46,750
+داخل خلية كويس وبيعملها infection غالبا بيوفر
+
+352
+00:27:46,750 --> 00:27:52,130
+immunity للخلية من other viruses من other viruses.
+
+353
+00:27:52,130 --> 00:27:59,750
+فلذلك تُعطى هذه اللقاحات على ثلاث جرعات متباعدة
+
+354
+00:27:59,750 --> 00:28:04,050
+على ثلاث جرعات متباعدة، كل ما ما على حد يبقى
+
+355
+00:28:04,050 --> 00:28:08,440
+كبسولة كبسولة كبسولة. طب بتتكلم عن كبسول احنا
+
+356
+00:28:08,440 --> 00:28:13,440
+بتمر عبر مين؟ عبر المعدة، طب والمعدة شو بتعمل؟
+
+357
+00:28:13,440 --> 00:28:17,720
+حامضية وقوية وبتقتل البكتيريا وبتقتل الفيروسات؟
+
+358
+00:28:17,720 --> 00:28:22,200
+بتقتل الفيروسات، لذلك يُعطى في كبسولة خاصة بيسموها
+
+359
+00:28:22,200 --> 00:28:29,910
+Enteric-coated Capsule يعني بتحميها من وين؟ من الـacid
+
+360
+00:28:29,910 --> 00:28:34,290
+أو الحامض تبع المعدة وبالتالي بتوصلها للـintestine
+
+361
+00:28:34,290 --> 00:28:38,550
+وهناك في الـintestine بالذوب وبتبدأ الفيروسات تعمل
+
+362
+00:28:38,550 --> 00:28:43,310
+mild infection أو asymptomatic infection بالأخرى
+
+363
+00:28:43,310 --> 00:28:47,190
+وبتوفر مناعة ضد هذه السلالات اللي احنا ذكرنا
+
+364
+00:28:55,900 --> 00:28:57,560
+الفيروس الثاني في السلسلة اللي هو ال
+
+365
+00:28:57,560 --> 00:29:01,800
+Papillomavirus. والفيروس الثاني في السلسلة اللي هو 
+
+366
+00:29:01,800 --> 00:29:02,480
+هو الـPapillomavirus. والفيروس الثاني في السلسلة
+
+367
+00:29:02,480 --> 00:29:04,340
+اللي هو الـPapillomavirus. والفيروس الثاني في
+
+368
+00:29:04,340 --> 00:29:05,280
+السلسلة اللي هو الـ...  الفيروس الثاني في السلسلة اللي هو
+
+369
+00:29:05,280 --> 00:29:06,440
+الفيروس الثاني في السلسلة اللي هو الـ... الفيروس الثاني
+
+370
+00:29:06,440 --> 00:29:06,780
+في السلسلة اللي هو الـ... الفيروس الثاني في السلسلة اللي
+
+371
+00:29:06,780 --> 00:29:08,540
+هو الـ... الفيروس الثاني في السلسلة اللي هو الـ...
+
+372
+00:29:08,540 --> 00:29:08,920
+الفيروس الثاني في السلسلة اللي هو الـ... الفيروس الثاني
+
+373
+00:29:08,920 --> 00:29:12,940
+في السلسلة اللي هو الـ... الفيروس الثاني في السلسلة اللي هو
+
+374
+00:29:12,940 --> 00:29:18,620
+الفيروس الثاني في السلسلة اللي هو الـ...
+
+375
+00:29:19,660 --> 00:29:24,280
+Particle يعني اللي طلع هذا الشكل هو software. 
+
+376
+00:29:24,280 --> 00:29:28,540
+برنامج حاسوب لكن طلع الصورة الحقيقية under the 
+
+377
+00:29:28,540 --> 00:29:32,860
+electron microscope أليست قريبة؟ قريبة لكن غير 
+
+378
+00:29:32,860 --> 00:29:36,340
+ملونة يعني ما يمكن يكون لو احنا أخذنا صورة ملونة
+
+379
+00:29:36,340 --> 00:29:39,060
+للفيروس بالـ electron microscope someday اللي جاي
+
+380
+00:29:39,060 --> 00:29:46,680
+أجمل مما الـ computer صور طيب human papilloma virus
+
+381
+00:29:46,680 --> 00:29:51,770
+أو HPV causes papillomas والـ papillomas are benign
+
+382
+00:29:51,770 --> 00:29:56,510
+tumors، benign يعني حميدة، مش malignant، خبيثة، 
+
+383
+00:29:56,510 --> 00:30:02,290
+عكسها، of squamous cells وبالتالي بالعربي البسيط،
+
+384
+00:30:02,290 --> 00:30:08,550
+warts on the skin، يعني بثور على الجلد، لكن هناك
+
+385
+00:30:08,550 --> 00:30:15,370
+استثناء بعض الـ HPV-Types، خصوصًا الـType 16 و18،
+
+386
+00:30:15,370 --> 00:30:19,730
+يمكن أن يسببا سرطانًا في عنق الرحم والرأس، إذا في
+
+387
+00:30:19,730 --> 00:30:26,610
+سلالات خاصة 16 و18، إيش بتسبب سرطانًا؟ إذا
+
+388
+00:30:26,610 --> 00:30:30,570
+الـPapilloma virus could be classified as an
+
+389
+00:30:30,570 --> 00:30:39,530
+oncovirusالـ HPV .. أفضل من الـ HHV8 الهيومان هيربس
+
+390
+00:30:39,530 --> 00:30:45,070
+فيروس type 8 اللي هو oncovirus إيش كمان فيروسات؟
+
+391
+00:30:45,070 --> 00:30:48,750
+ابشتين بار فيروس نازوفارنجال كارسينوما بوركيتس
+
+392
+00:30:48,750 --> 00:30:52,290
+لينفومة other lymphomas مظبوط؟ يبقى في عندي مجموعة
+
+393
+00:30:52,290 --> 00:30:57,070
+من الفيروسات ارتبطت ارتباط وثيق بمين؟ بالسرطان
+
+394
+00:30:57,070 --> 00:31:01,880
+واحد منهم الـ papilloma virus في الجدول اللي أعطيته
+
+395
+00:31:01,880 --> 00:31:05,720
+في أول المحاضرة في آخر عمود كان فيه سؤال هل هناك
+
+396
+00:31:05,720 --> 00:31:09,720
+vaccine أم لا؟ وقلنا لكم اشطبوا كفى بالخطأ مكتوبة
+
+397
+00:31:09,720 --> 00:31:14,840
+no لكن قلنا أنه في yes وبنفخر دوما بأنه العلم
+
+398
+00:31:14,840 --> 00:31:19,740
+أنتج vaccine ضد السرطان هو الواقع مش ضد السرطان ضد
+
+399
+00:31:19,740 --> 00:31:23,780
+الفيروس اللي هو الـ papilloma virus اللي بيسبب الـ
+
+400
+00:31:23,780 --> 00:31:25,520
+cervix و الـ penile cancer
+
+401
+00:31:28,500 --> 00:31:30,900
+احنا في الـ .. الـ .. الفيروس اللي سابق قلنا لكم
+
+402
+00:31:30,900 --> 00:31:33,900
+راجعوا على كلمة linear double-stranded linear هنا
+
+403
+00:31:33,900 --> 00:31:37,720
+double-stranded إيش؟ circular DNA and an
+
+404
+00:31:37,720 --> 00:31:41,780
+icosahedral nucleocapsid واضح إن احنا بنتكلم عن
+
+405
+00:31:41,780 --> 00:31:46,660
+شكل غريب من بعض لكن الـ .. الـ .. الـ .. المادة
+
+406
+00:31:46,660 --> 00:31:51,340
+الوراثية مختلفة بإنه double-stranded linear هناك
+
+407
+00:31:51,340 --> 00:31:55,660
+وهنا double-stranded circular تعالوا ننظر الآن على
+
+408
+00:31:55,660 --> 00:32:00,760
+الفيروس هذا كيف يسبب سرطان هنا two of the proteins
+
+409
+00:32:00,760 --> 00:32:06,720
+باسمهم E6 وE7 E6 E7 are implicated in 
+
+410
+00:32:06,720 --> 00:32:11,180
+carcinogenesis implicated يعني متهمة أو متورطة
+
+411
+00:32:11,180 --> 00:32:17,630
+متورطة في الـ carcinogenesis هناك Tumor suppressor
+
+412
+00:32:17,630 --> 00:32:23,250
+genes مشهورين جدا وواحد اسمه P53 وواحد اسمه 
+
+413
+00:32:23,250 --> 00:32:26,750
+Retinoblastoma و Retinoblastoma ما راح معانا ..
+
+414
+00:32:26,750 --> 00:32:32,270
+Retinoblastoma ما راح معانا في الـ human herpes virus
+
+415
+00:32:32,270 --> 00:32:37,750
+type 8 تمام؟ وقلنا لكم كيف بيشتغل، الآن الـ E6 و
+
+416
+00:32:37,750 --> 00:32:42,690
+E7 بيطلقوا بروتينات بيعملوا inactivation لهذه
+
+417
+00:32:42,690 --> 00:32:48,140
+الجينات لما بيعملوا inactivation للـ P53 و للريتنو
+
+418
+00:32:48,140 --> 00:32:51,340
+بلاستوما genes، إيش تقول إن وظيفتهم؟ tumor
+
+419
+00:32:51,340 --> 00:32:54,800
+suppressor، هم اللي موقفين جينات السرطان إنهم
+
+420
+00:32:54,800 --> 00:33:00,760
+يشتغلوا، شيلتهم وعطلتهم أنا، بطلوا قادرين يعملوا
+
+421
+00:33:00,760 --> 00:33:05,120
+suppression لمين؟ للسرطان، فسرطان will develop
+
+422
+00:33:06,000 --> 00:33:11,280
+وصلت الصورة إذا كيف .. كيف للـ human papilloma virus
+
+423
+00:33:11,280 --> 00:33:15,940
+أن يسبب السرطان من خلال الـ E6 و الـ E7 اللي بيعمل
+
+424
+00:33:15,940 --> 00:33:19,400
+الـ inactivation لكل من اللي هم الـ P53 و الـ
+
+425
+00:33:19,400 --> 00:33:22,380
+retinoplastoma وإنها tumor suppressor genes
+
+426
+00:33:25,590 --> 00:33:28,490
+There are at least one hundred types of papilloma
+
+427
+00:33:28,490 --> 00:33:33,930
+viruses Classified
+
+428
+00:33:33,930 --> 00:33:37,530
+primarily on the basis of DNA restriction fragment
+
+429
+00:33:37,530 --> 00:33:38,190
+analysis 
+
+430
+00:33:55,530 --> 00:34:01,250
+بقول لنا إنه فيه هناك يعني ميل لـ certain types to
+
+431
+00:34:01,250 --> 00:34:03,630
+infect certain tissues زي ما شفنا قبل شوية احنا 
+
+432
+00:34:03,630 --> 00:34:06,610
+برضه في الـ rotavirus شفنا سلالات بتصيب الـ
+
+433
+00:34:06,610 --> 00:34:08,670
+respiratory tract شفنا سلالات بتصيب الـ
+
+434
+00:34:08,670 --> 00:34:12,190
+gastrointestinal tract شفنا سلالات بتصيب المثانة
+
+435
+00:34:12,190 --> 00:34:16,130
+صح ولا لأ وبالتالي نفس الشيء مثلًا بقولنا إن skin
+
+436
+00:34:16,130 --> 00:34:23,640
+warts are caused by HPV 1 من واحد إلى أربعة هدول
+
+437
+00:34:23,640 --> 00:34:30,100
+كلمة HPV 1 to through HPV 4 يعني 2, 3 و 4 والـ as
+
+438
+00:34:30,100 --> 00:34:34,220
+genital warts اللي مرتبطة بالأعضاء التناسلية are
+
+439
+00:34:34,220 --> 00:34:39,300
+usually caused by HPV 6 و HPV 11 إذا الـ vaccine
+
+440
+00:34:39,300 --> 00:34:43,960
+هيكون ضمن الـ vaccine اللي حكينا عنه قبل قليل هيكون
+
+441
+00:34:43,960 --> 00:34:48,720
+ضد اللي هم الـ strains اللي بتسبب جونة الـ genital
+
+442
+00:34:48,720 --> 00:34:52,740
+warts اللي هي ممكن تؤدي إلى السرطان طلعوا الآن
+
+443
+00:34:52,740 --> 00:34:58,500
+approximately 30 types من الـ HPV تصيب الـ
+
+444
+00:34:58,500 --> 00:34:59,560
+genital tract
+
+445
+00:35:02,640 --> 00:35:06,220
+Papilloma viruses برضه من الجدول البسيط اللي احنا
+
+446
+00:35:06,220 --> 00:35:09,720
+قعدنا فيه أول المحاضرة بتنتقل عن طريقين اللي هو
+
+447
+00:35:09,720 --> 00:35:14,680
+skin to skin contact و sexual contact skin to skin
+
+448
+00:35:14,680 --> 00:35:18,660
+contact and by genital contact genital warts are
+
+449
+00:35:18,660 --> 00:35:21,560
+among the most common sexually transmitted disease
+
+450
+00:35:21,560 --> 00:35:27,040
+يعني احنا طبعًا أنتم عارفين لما احنا بنقول STD
+
+451
+00:35:27,040 --> 00:35:30,940
+sexually transmitted diseases مجموعة من الأمراض
+
+452
+00:35:30,940 --> 00:35:37,760
+الجنورية clamydia, syphilis, herpes virus type 2، 
+
+453
+00:35:37,760 --> 00:35:44,960
+مظبوط، هي أنها من الـ human papilloma virus الـ HPV
+
+454
+00:35:44,960 --> 00:35:48,920
+ولما أنا أقول one of the most common يبقى الآن
+
+455
+00:35:48,920 --> 00:35:53,320
+نسبة حدوثه في الأعمار الجنسية عالية أيضًا مرتفعة
+
+456
+00:35:53,320 --> 00:35:56,860
+طبعًا الـ most common أنا بقول one of the most
+
+457
+00:35:56,860 --> 00:36:01,740
+common لكن مين الـ most common؟ الكلاميديا number
+
+458
+00:36:01,740 --> 00:36:07,940
+one بيجي وراها الجنورية في الأمراض الـ STD لكن بشكل
+
+459
+00:36:07,940 --> 00:36:11,460
+عام كل الأمراض اللي بتنتقل عن طريق الجنس في العالم
+
+460
+00:36:11,460 --> 00:36:17,520
+الغربي هي الآن بنسبة مرتفعة وعالية Skin warts are
+
+461
+00:36:17,520 --> 00:36:20,320
+more common in children and young adults and tend
+
+462
+00:36:20,320 --> 00:36:25,440
+to regress in older adults يعني بتكون اللي هي الـ
+
+463
+00:36:25,440 --> 00:36:30,120
+skin warts بتكون نسبتها أعلى في الأطفال وبتقل مع
+
+464
+00:36:30,120 --> 00:36:34,220
+الكبار لكن طبعًا عكس هيكون مين اللي هو الـ sexually
+
+465
+00:36:34,220 --> 00:36:39,690
+transmitted HPV ممكن ينتقل من الأم المصابة إلى 
+
+466
+00:36:39,690 --> 00:36:42,310
+the neonate during childbirth يعني إذا احنا بنقول
+
+467
+00:36:42,310 --> 00:36:47,910
+هو genital يبقى ممكن ينتقل من الأم إلى المولود
+
+468
+00:36:47,910 --> 00:36:50,690
+causes warts in the mouth and the respiratory
+
+469
+00:36:50,690 --> 00:36:54,170
+tract يعني حتى داخل الفم وفي الجهاز التنفسي
+
+470
+00:36:54,170 --> 00:36:59,480
+خصوصًا في الحنجرة للطفل many species
+
+471
+00:36:59,480 --> 00:37:03,900
+of animals are infected with their own types of
+
+472
+00:37:03,900 --> 00:37:07,040
+papilloma viruses لكن لا تنتقل إلى مين؟ إلى
+
+473
+00:37:07,040 --> 00:37:15,460
+الإنسان، ولا تعتبر مصدر عدوى مهم للإنسان. بعطي
+
+474
+00:37:15,460 --> 00:37:18,480
+genesis and immunity كيف لهذا الفيروس أن يحدث
+
+475
+00:37:18,480 --> 00:37:23,480
+المرض؟ وإيش الـ immunity اللي بيكون الإنسان ضد هذا
+
+476
+00:37:23,480 --> 00:37:25,600
+المرض؟
+
+477
+00:37:27,110 --> 00:37:31,650
+Papilloma viruses infect squamous epithelial cells
+
+478
+00:37:31,650 --> 00:37:34,930
+and induce within those cells a characteristic
+
+479
+00:37:34,930 --> 00:37:37,110
+cytoplasmic vacuole
+
+480
+00:37:46,750 --> 00:37:52,470
+يعني مرتبطة، مميزة، علامة مميزة لهذا الـ .. الـ ..
+
+481
+00:37:52,470 --> 00:37:55,910
+الـ .. الـ .. الفيروس وهذه الـ vacuolated cell
+
+482
+00:37:55,910 --> 00:38:03,740
+بيسموها وهي coil sites وهي hallmark of infection
+
+483
+00:38:03,740 --> 00:38:07,680
+by these viruses فاكرين لما مرة قلنا إحدى الـ owls
+
+484
+00:38:07,680 --> 00:38:14,460
+eye للـ CMV ولما قلنا inclusion bodies للـ rabies virus
+
+485
+00:38:14,460 --> 00:38:19,460
+أيضًا الـ coil sites هذه hallmark لمين؟ للـ papilloma
+
+486
+00:38:19,460 --> 00:38:20,160
+virus
+
+487
+00:38:25,840 --> 00:38:30,140
+معظم الورمات هي حميدة ولا تتطور إلى أن تكون
+
+488
+00:38:30,140 --> 00:38:36,100
+خبيثة، لكن الإصابة بالـ HPV هي مرتبطة بالسرطانات
+
+489
+00:38:36,100 --> 00:38:39,080
+من الرحم وعنق الرحم والقضيب
+
+490
+00:38:47,520 --> 00:38:51,360
+واشرحنا احنا يمكن الجملة الأخيرة شرحناها أن الـ
+
+491
+00:38:51,360 --> 00:38:55,860
+E6 و E7 هم المسؤولين عن الـ suppression لـ tumor
+
+492
+00:38:55,860 --> 00:39:00,880
+suppressor genes اللي هم الـ P53 و Retinoblastoma
+
+493
+00:39:00,880 --> 00:39:06,660
+factors طبعًا هذا شكل من أشكال الـ skin warts وهذا
+
+494
+00:39:06,660 --> 00:39:11,100
+شكل من أشكال الـ genital warts اللي شايفينه طبعًا
+
+495
+00:39:11,100 --> 00:39:14,200
+هنا الـ growth بيكون
+
+496
+00:39:17,740 --> 00:39:21,760
+قد يكون بمستويات مختلفة، مش مستوى واحد، قد يكون
+
+497
+00:39:21,760 --> 00:39:25,720
+أكبر من ذلك، وقد يكون أصغر من ذلك، وبيصل لمراحل
+
+498
+00:39:25,720 --> 00:39:31,520
+معينة، وقد يشفى تلقائيًا، أو قد يعالج من خلال
+
+499
+00:39:31,520 --> 00:39:35,920
+الحرق، إزالة بالحرق، أو بإزالة بالـ Liquid
+
+500
+00:39:35,920 --> 00:39:41,670
+Nitrogen، لكن المؤكد أن هذا الشكل البسيط من الـ 
+
+501
+00:39:41,670 --> 00:39:46,790
+words شكل مميز و الـdiagnosis غالبا بيكون clinical 
+
+502
+00:39:46,790 --> 00:39:50,310
+يعني مش محتاجين laboratory diagnosis عشان نتعرف
+
+503
+00:39:50,310 --> 00:39:53,950
+على مين على اللي هو الـvirus المرة الجاية إن شاء 
+
+504
+00:39:53,950 --> 00:39:54,890
+الله بنكمل
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/AmzGBCqSgus_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/AmzGBCqSgus_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7d682cdecc6510dbbf20048e6c53d6c874f27d64
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/AmzGBCqSgus_raw.srt
@@ -0,0 +1,2020 @@
+1
+00:00:21,260 --> 00:00:23,980
+طيب بسم الله الرحمن الرحيم الحمد لله رب العالمين و
+
+2
+00:00:23,980 --> 00:00:27,300
+الصلاة والسلام وعلى سيدنا محمد وعلى آله وصحبه ومن
+
+3
+00:00:27,300 --> 00:00:30,640
+ساعد بيه ليوم الدين وبعد موضوع جديد اليوم ان شاء
+
+4
+00:00:30,640 --> 00:00:34,100
+الله اللي هو DNA non-enveloped viruses واحنا
+
+5
+00:00:34,100 --> 00:00:37,340
+اتفقنا من البداية ان ال viruses could be
+
+6
+00:00:37,340 --> 00:00:41,560
+classified based on their nuclear material into
+
+7
+00:00:41,560 --> 00:00:46,690
+DNA viruses وRNA virusesالديانيو فيروس كانت انفلوب
+
+8
+00:00:46,690 --> 00:00:52,370
+و لون انفلوب درسنا في ال انفلوب تلت مجموعات او على
+
+9
+00:00:52,370 --> 00:00:55,530
+الاقل تطبقنا في تلت مجموعات المجموعة الأولى هي ال
+
+10
+00:00:55,530 --> 00:00:58,390
+herpes viruses المجموعة التانية كانت المفروض انها
+
+11
+00:00:58,390 --> 00:01:02,950
+تكون box viruses والثالثة كانت الهيبادنة فيروس و
+
+12
+00:01:02,950 --> 00:01:07,280
+الهيبادنةلم نتطرق لها بتفاصيل لأننا كنا هجرسها ان
+
+13
+00:01:07,280 --> 00:01:11,760
+شاء الله من مجموعة الهيباطايتس فيروس اليوم هتحدث
+
+14
+00:01:11,760 --> 00:01:16,480
+بإذن الله عن ال DNA non-enveloped viruses وهي ايضا
+
+15
+00:01:16,480 --> 00:01:23,680
+مجموعة مكوّنة من ثلاثة وهي تدبل الصغير يلخص معظم
+
+16
+00:01:23,680 --> 00:01:27,920
+الأشياء الهمة في هذه المجموعة
+
+17
+00:01:30,350 --> 00:01:34,350
+العمود الأول هو ال adenoviruses human papilloma
+
+18
+00:01:34,350 --> 00:01:40,370
+viruses و ال barvo virus B19 لو نظرنا على العمود
+
+19
+00:01:40,370 --> 00:01:43,740
+الثاني هلاج ال mood of the transmissionالـ
+
+20
+00:01:43,740 --> 00:01:46,940
+Adenovirus هناك أكثر من طريقة انتقال مثل الـ
+
+21
+00:01:46,940 --> 00:01:52,120
+Respiratory Route الـ Fecal Oral Route والـ Direct
+
+22
+00:01:52,120 --> 00:01:55,540
+Contact يعني بالاتصال المباشر بينما الـ Human
+
+23
+00:01:55,540 --> 00:01:59,480
+Papilloma Viruses فقط طريقتين اللي هم الـ Sexual و
+
+24
+00:01:59,480 --> 00:02:04,980
+Skin Contact والـ Parvo Virus B19 طريقتين أيضا
+
+25
+00:02:04,980 --> 00:02:08,660
+واحدة منهم الـ Transplacental والتانية Respiratory
+
+26
+00:02:08,660 --> 00:02:15,280
+العمول الثالث هل هناكdifferent strains that can
+
+27
+00:02:15,280 --> 00:02:19,800
+cause different diseases يعني من هذا الصنف من ال
+
+28
+00:02:19,800 --> 00:02:23,260
+adenovirus على سبيل المثال usual أصناف بتسبب أمراض
+
+29
+00:02:23,260 --> 00:02:27,760
+مختلفة نعم في ال adenovirus نعم وفي ال human
+
+30
+00:02:27,760 --> 00:02:32,400
+papilloma virus نعم لكن في ال parvo virus B19 it
+
+31
+00:02:32,400 --> 00:02:35,760
+is only one strain it is only one disease تمام
+
+32
+00:02:35,760 --> 00:02:42,470
+مافيش أمراض مختلفةالان اقول الرابع هل تسبب هذه
+
+33
+00:02:42,470 --> 00:02:48,390
+الأنواع أو بعضا منها سرطانات؟ في ال adenovirus نعم
+
+34
+00:02:48,390 --> 00:02:53,990
+لكن إجابة مشروطة في الحيوانات فقط بينما في ال
+
+35
+00:02:53,990 --> 00:02:58,190
+human papilloma virus نعم تسبب سرطان في الإنسان
+
+36
+00:02:58,190 --> 00:03:03,950
+والأخير هو ال barvo virus B19 لا يسبب أي نوع من
+
+37
+00:03:03,950 --> 00:03:10,360
+السرطانةالأخير أو العمود الأخير هل هناك vaccine
+
+38
+00:03:10,360 --> 00:03:16,620
+متاح لهذه الفيروسات الأول نعم لكن ليس للمدنيين ولم
+
+39
+00:03:16,620 --> 00:03:22,640
+لمين للعسكر للجيوش ال human papillomavirus إيش
+
+40
+00:03:22,640 --> 00:03:27,780
+الإجابة اللي مكتوبة هنا no لأ هي مش no هي yes بدنا
+
+41
+00:03:27,780 --> 00:03:32,800
+نشطبها و نكتب إيش الآن yes و هنقول كل إيش جاله no
+
+42
+00:03:32,800 --> 00:03:38,780
+و هنقول إيش جاله yes تمامالبربو فيه فيروس 19 برضه
+
+43
+00:03:38,780 --> 00:03:42,640
+مافيش له فيروس فاكسين، إذا هذا الجدول البسيط
+
+44
+00:03:42,640 --> 00:03:47,000
+يلخصنا الحالة للفيروسات الثلاثة اللي احنا حدثهم
+
+45
+00:03:47,000 --> 00:03:51,760
+فيه تحت عنوان ال DNA Non-Enveloped Virus ال
+
+46
+00:03:51,760 --> 00:03:56,020
+adenovirus هو الأشهر على الإطلاق والأكثرها شيوعا
+
+47
+00:03:56,020 --> 00:04:01,790
+ويمكن الأكثرها ايضا انتشارا واحداثا للامرأةهذا
+
+48
+00:04:01,790 --> 00:04:05,450
+الشكل الجميل لهذا الفيروس لابد ان نتذكره جيدا
+
+49
+00:04:05,450 --> 00:04:09,790
+عندما نرى هذا الشكل للفيروس او اي فيروس بهذا الشكل
+
+50
+00:04:09,790 --> 00:04:14,650
+هو الادينو فيروس لماذا هو الوحيد اللذي يمتلك ال
+
+51
+00:04:14,650 --> 00:04:18,210
+fibers اللي انتوا شايفينها اللي طال ع المنوان من
+
+52
+00:04:18,210 --> 00:04:23,270
+التقاء المثلثات في الecosahedral capsid تاعت
+
+53
+00:04:23,270 --> 00:04:27,710
+الecosahedral capsid عبارة عن انها متلتات الزوايا
+
+54
+00:04:27,710 --> 00:04:31,660
+اللي فيها التقاء المثلثات بيسموها ال vertisمن كل
+
+55
+00:04:31,660 --> 00:04:36,800
+الـ Vertis موجودة في الفيروس تظهر الفيبر وهذا
+
+56
+00:04:36,800 --> 00:04:41,400
+الفيبر له أهمية كبيرة غير الشكل اللي نراه له أهمية
+
+57
+00:04:41,400 --> 00:04:45,100
+كبيرة في دورة حياة الفيروس في الـ Antigenic
+
+58
+00:04:45,100 --> 00:04:48,780
+Variation للفيروس سنعرف أن الفيروس فيه 41
+
+59
+00:04:48,780 --> 00:04:54,480
+Serotypes الـ 41 Serotypes مبنيين على هذا الفيبر
+
+60
+00:04:54,480 --> 00:04:57,550
+اللي نتكلم عنه اللي هي الخيوط اللي موجودة هناأيضا
+
+61
+00:04:57,550 --> 00:05:01,170
+حلج أن الفيروس من صفاته أنه بيعمل hemagglutination
+
+62
+00:05:01,170 --> 00:05:05,790
+يعني بيجمع Red Blood Cell عارفين مين المسؤول عن
+
+63
+00:05:05,790 --> 00:05:09,850
+hemagglutination؟ برضه اللي هو ال fiber protein
+
+64
+00:05:09,850 --> 00:05:13,290
+اللي موجود على هذا الفيروس، إذا ليس فقط الشكل
+
+65
+00:05:13,290 --> 00:05:19,000
+وانما دخل كبير في الوظيفةفاحنا قلنا إن هو الأهم من
+
+66
+00:05:19,000 --> 00:05:22,880
+المجموعة اللي معانا ال adenovirus لماذا .. لماذا
+
+67
+00:05:22,880 --> 00:05:27,780
+هو الأهم انظروا إلى اللوحة و فلنراجع مع سويا أسماء
+
+68
+00:05:27,780 --> 00:05:33,310
+الأمراض اللي بسببها هذا ال virusفرنجايتس مين بيسبب
+
+69
+00:05:33,310 --> 00:05:37,850
+bacterial pharyngitis؟ Stratococcus biogenes
+
+70
+00:05:37,850 --> 00:05:40,990
+Stratococcus biogenes هي الأشهر في البكتيريا ال
+
+71
+00:05:40,990 --> 00:05:44,130
+adenovirus هو الأشهر على الإطلاق في ال viruses في
+
+72
+00:05:44,130 --> 00:05:48,210
+إحداث ال pharyngitis بل و هناك بعض المراجعة تقول
+
+73
+00:05:48,210 --> 00:05:52,670
+إن نسبة إصابة الأطفال بال adenovirus pharyngitis
+
+74
+00:05:52,670 --> 00:05:55,050
+أكتر من نسبة إصابة الأطفال بال bacterial
+
+75
+00:05:55,050 --> 00:05:59,390
+pharyngitisلذلك لما كانوا يقولولكوا انه مش كل
+
+76
+00:05:59,390 --> 00:06:04,570
+التهاب حلق بيحتاج antibiotic هي مقولة صحيحة انه قد
+
+77
+00:06:04,570 --> 00:06:08,730
+يكون adenovirus كوندركتيفيركس التهاب ملتحة متل عين
+
+78
+00:06:08,730 --> 00:06:15,370
+ال common cold وهو ناقف هل هي المسبب او عادل فيروس
+
+79
+00:06:15,370 --> 00:06:19,530
+هي المسبب الوحيد لل common cold لأ ولا المسبب
+
+80
+00:06:19,530 --> 00:06:23,730
+الرئيسي المسبب الرئيسي لل common cold هو ال rhino
+
+81
+00:06:23,730 --> 00:06:32,120
+virusهو أيضا يسبب أعراض ال common cold نيمونيا
+
+82
+00:06:32,120 --> 00:06:37,020
+كيراتو كوندكتيفيتس hemorrhagic cystitis وكلمة
+
+83
+00:06:37,020 --> 00:06:41,800
+hemorrhagic cystitis يعني التهاب المثانى النزفي
+
+84
+00:06:41,800 --> 00:06:49,880
+يعني بيكون فيه دم في البولوبكون كمان قلة في إدرار
+
+85
+00:06:49,880 --> 00:06:53,240
+البول يعني ممكن يكون dysuria حتى مافيش بول خالص
+
+86
+00:06:53,240 --> 00:06:57,340
+يعني يصير وينزل فقط blood keratoconjectivitis
+
+87
+00:06:57,340 --> 00:07:01,750
+التهاب القرنية والاتهاب ملتحمة العينالـ
+
+88
+00:07:01,750 --> 00:07:06,810
+Gastroenteritis، شوفوا الآن التنوع في الأمراض من
+
+89
+00:07:06,810 --> 00:07:10,330
+الـ Upper Respiratory Tract إلى الـ Cystitis إلى
+
+90
+00:07:10,330 --> 00:07:15,170
+Gastroenteritis إلى Eye Infection، وهذا بيأكد على
+
+91
+00:07:15,170 --> 00:07:19,270
+ما ذكرناه سابقاً من طرق انتقال الفيروس، اللي هي
+
+92
+00:07:19,270 --> 00:07:24,170
+الثلاثة. Some viruses من الـ Adenoviruses can
+
+93
+00:07:24,170 --> 00:07:26,930
+cause sarcomas in rodents.
+
+94
+00:07:29,780 --> 00:07:36,360
+لكن ليس في الانسان من الخصائص المهمة لهذا الفيروس
+
+95
+00:07:36,360 --> 00:07:41,300
+انها non-enveloped double-stranded linear DNA
+
+96
+00:07:41,300 --> 00:07:45,680
+المهم ان نركز على كلمة linear DNA لان الفيروس اللي
+
+97
+00:07:45,680 --> 00:07:48,680
+بعده هلاجيه circular DNA
+
+98
+00:07:50,980 --> 00:07:54,660
+الكبسيد هي ايكوزاهيدرالكبسيد و they are the only
+
+99
+00:07:54,660 --> 00:08:00,180
+viruses with a fiber protruding
+
+100
+00:08:00,180 --> 00:08:04,600
+تخرج من each of the twelve vertices of the capsid
+
+101
+00:08:10,420 --> 00:08:13,960
+أيش وظيفة الـ Fiber؟ It is the organ of attachment
+
+102
+00:08:13,960 --> 00:08:19,260
+يعني خلايانا اللي بتنصاها هي الـ Receptor أو عليها
+
+103
+00:08:19,260 --> 00:08:24,940
+Receptor لهذا الـ Fiber and it functions as a
+
+104
+00:08:24,940 --> 00:08:27,460
+hemagglutinin وكلكم عارفين إيش يعني Hemagglutinin
+
+105
+00:08:27,460 --> 00:08:31,820
+لذلك هنلاقي إنه ضمن ال diagnostic test
+
+106
+00:08:31,820 --> 00:08:36,780
+Hemagglutination Inhibition Assay يعني ممكن نكشف
+
+107
+00:08:36,780 --> 00:08:42,930
+عامله من خلال هذه الطريقة أو الفكرةمش بس كمان ال
+
+108
+00:08:42,930 --> 00:08:47,470
+.. ال .. ال fiber بيشتغل hemagglutinin و بيشتغل
+
+109
+00:08:47,470 --> 00:08:51,710
+الارتباط، لو احنا جسنا من الفيروس، يعني اتخلصنا من
+
+110
+00:08:51,710 --> 00:08:54,870
+كل شيء من الفيروس و فقط طلعنا ال fibers هذه و
+
+111
+00:08:54,870 --> 00:08:58,270
+حقنها في الخلايا، هلاج ان الخلايا بتموت، ما تحكي
+
+112
+00:08:58,270 --> 00:09:05,230
+ان هو toxic او cytotoxic to the cellsهناك 41 سيرو
+
+113
+00:09:05,230 --> 00:09:10,470
+تايب معروفين للأدينو فيروس وهذا التغير في السيرو
+
+114
+00:09:10,470 --> 00:09:15,510
+تايب مبني على التغير في الفيبر كمان مرة فيبر
+
+115
+00:09:15,510 --> 00:09:19,850
+بروتيم وهو type specific ايش type specific؟ يعني
+
+116
+00:09:19,850 --> 00:09:26,210
+لو الفيروس X واحد من ال 41 دخل باسم الإنسان باسم
+
+117
+00:09:26,210 --> 00:09:30,490
+الإنسان بيكولله مناعة هذا مناعة specific لفقط
+
+118
+00:09:30,490 --> 00:09:35,790
+strain واحدلو دخل اتنين لازم يكوّله مناعة مرة اخرى
+
+119
+00:09:35,790 --> 00:09:41,810
+لكن الشيء المطمئن في هذا الفيروس انه fifty percent
+
+120
+00:09:41,810 --> 00:09:45,690
+من ال infections are asymptomatic خمسين بالمائة
+
+121
+00:09:45,690 --> 00:09:52,800
+asymptomatic و معظم بل نقولجل تمام الأمراض اللي
+
+122
+00:09:52,800 --> 00:09:57,260
+بتسببها هذا ال virus can resolve spontaneously،
+
+123
+00:09:57,260 --> 00:10:00,020
+إيش يعني resolve spontaneously؟ يعني بالطيب لحالته
+
+124
+00:10:00,020 --> 00:10:04,180
+الشفاء تلقائيا بدون علاج، لذلك على فكرة مافيش
+
+125
+00:10:04,180 --> 00:10:09,400
+antiviral لهذا ال disease، في vaccine لكن زي ما
+
+126
+00:10:09,400 --> 00:10:13,440
+أحكيلكوا، vaccine لمين؟ للملتاري، للملتاري
+
+127
+00:10:16,170 --> 00:10:20,110
+في شغل ممكن في المستقبل يعني تساهم في إنتاج
+
+128
+00:10:20,110 --> 00:10:25,330
+vaccine لكن لحد الآن هذا ال group specific antigen
+
+129
+00:10:25,330 --> 00:10:27,930
+كلمة group specific يعني هذا common لكل ال
+
+130
+00:10:27,930 --> 00:10:32,310
+adenovirus يعني يفترض إيش يا بنات؟ يفترض إنه لو
+
+131
+00:10:32,310 --> 00:10:37,410
+أنا اقدرت أخد هذا ال antigen تمام؟ و أعمله ك
+
+132
+00:10:37,410 --> 00:10:42,520
+vaccine ال vaccine هذا يوفر لي حماية من مين؟من كل
+
+133
+00:10:42,520 --> 00:10:46,640
+ال adenovirus لكن للأسف ما بصير، عارفين ليش؟ لأن
+
+134
+00:10:46,640 --> 00:10:51,440
+هو أصلا مش على الأطراف هذا ال common antigen
+
+135
+00:10:51,440 --> 00:10:56,680
+والنمو الموجود داخل اللي هو ال capsid نفسها، فداخل
+
+136
+00:10:56,680 --> 00:11:01,220
+ال capsid الفيروس عشان يصير له neutralization،
+
+137
+00:11:01,220 --> 00:11:05,990
+لازم ال antibody وين يرتبط؟على ال fibers يبقى لو
+
+138
+00:11:05,990 --> 00:11:11,130
+قدرت انا الاقي antigen common في المنطقة هذه في
+
+139
+00:11:11,130 --> 00:11:15,250
+منطقة ال fibers تمام ممكن اصنع بالفعل vaccine يكون
+
+140
+00:11:15,250 --> 00:11:18,850
+مناسب للواحد واربعين لكن في هذه اللحظة و لحد هذه
+
+141
+00:11:18,850 --> 00:11:23,470
+اللحظة لم نستطيع الحصول على vaccine موحد لهذا ال
+
+142
+00:11:23,470 --> 00:11:29,830
+virus طيب في كمان شئ المهم كمان ان في ارتباط بين
+
+143
+00:11:29,830 --> 00:11:34,750
+ال serotype و بين ال diseaseيعني مش كل الـ
+
+144
+00:11:34,750 --> 00:11:39,890
+Serotype بيسببوا نفس المرض وانما هناك Serotype
+
+145
+00:11:39,890 --> 00:11:45,730
+متخصصة مثلا بيقولنا انه 12 و 18 و 31 عملوا
+
+146
+00:11:45,730 --> 00:11:50,150
+Sarcomasفي ال hamsters بتاع في ال hamsters اللي هم
+
+147
+00:11:50,150 --> 00:11:53,730
+الحيوان هذا اللي صورته موجودة أمامكم هذا اسمه
+
+148
+00:11:53,730 --> 00:11:57,350
+hamster وهو حيوان تجارب وعارفين كيف تكون ال
+
+149
+00:11:57,350 --> 00:12:01,330
+sarcomas تكونت ال sarcomas at the site of
+
+150
+00:12:01,330 --> 00:12:04,010
+injection يعني في المكان اللي احنا فيه حقاننا
+
+151
+00:12:04,010 --> 00:12:09,650
+الفيروس في الفقر تكون sarcomas لكن لم يحدث هذا
+
+152
+00:12:09,650 --> 00:12:13,970
+الكلام في الإنسانماذا استفدنا من اللوحة هذه؟
+
+153
+00:12:13,970 --> 00:12:18,490
+استفدنا انه في common group specific antigen ثاناء
+
+154
+00:12:18,490 --> 00:12:23,150
+في اندي specific serotype causes specific symptoms
+
+155
+00:12:23,150 --> 00:12:26,130
+وحنشوف كمان شوية تفاصيل اكتر عن هذا الكلام
+
+156
+00:12:26,130 --> 00:12:29,330
+الانينوفاياسيز
+
+157
+00:12:29,330 --> 00:12:33,370
+are transmitted usually by aerosols droplets عبر
+
+158
+00:12:33,370 --> 00:12:39,730
+الرذاذ from oral route من البراز إلى الفم وهذه
+
+159
+00:12:39,730 --> 00:12:44,240
+غالبا بتكون common في من؟في ال children ليش common
+
+160
+00:12:44,240 --> 00:12:50,740
+في ال children يا بنات؟ مش بس موضوع النظافة في
+
+161
+00:12:50,740 --> 00:12:54,540
+فترة من الأعمار من عمر الأطفال بتعرفوا على الأشياء
+
+162
+00:12:54,540 --> 00:12:58,680
+من خلال التذوق يا لو أعطناه مفتاح سوف يضعه في فمه
+
+163
+00:12:58,680 --> 00:13:04,060
+لو أعطناه أي أداء جلم أي حاجة يضعها في الفم الآن
+
+164
+00:13:04,060 --> 00:13:09,780
+هذا ال practice بالإضافة إلى عدم الوعي في موضوع
+
+165
+00:13:09,780 --> 00:13:15,260
+النظافة الشخصيةيزيد من احتمالية نقل الأمراض عبر
+
+166
+00:13:15,260 --> 00:13:18,540
+الفكرة الـoral route مش بس لهم، للأطفال و كمان
+
+167
+00:13:18,540 --> 00:13:21,380
+للبالغين في نفس الأسرة، يعني وين فيه أطفال، فيه
+
+168
+00:13:21,380 --> 00:13:26,200
+احتمالية انتقال أيضًا للأهل من خلال هذه ال route
+
+169
+00:13:26,200 --> 00:13:30,380
+Direct Inculation، إيش يعني Direct Inculation؟
+
+170
+00:13:30,380 --> 00:13:34,860
+يعني حق مباشرof conjunctivas by tonometers or
+
+171
+00:13:34,860 --> 00:13:38,320
+fingers أنا دايما بقولكوا الفينجر هذا أداة مهمة
+
+172
+00:13:38,320 --> 00:13:43,800
+جدا في نقل من العدوى خاصة في العين finger to eye
+
+173
+00:13:43,800 --> 00:13:47,640
+root بس في طريقة تانية اللي هي من خلال ال
+
+174
+00:13:47,640 --> 00:13:51,880
+tonometers شايفين الصورة هذه؟الصورة هذه هي عبارة
+
+175
+00:13:51,880 --> 00:13:56,220
+عن جهاز صغير بينجيس فيه ضغط العين إذا الـ
+
+176
+00:13:56,220 --> 00:14:01,240
+Tonometer هو جهاز لقياس ضغط العين كيف يشتغل هذا
+
+177
+00:14:01,240 --> 00:14:07,420
+الجهاز بيحط الجهاز على القرانية و بيدغط ضغط خفيفة
+
+178
+00:14:07,420 --> 00:14:11,900
+الآن القرانية أو العين بشكل عام هتعمل ضغط إلى
+
+179
+00:14:11,900 --> 00:14:18,370
+اتجاه المعاكس فبيجيسه الضغط من خلالExergen لا
+
+180
+00:14:18,370 --> 00:14:23,690
+pressure ومن ثم قياس الضغط المعاكس يبقى فيه تلامس
+
+181
+00:14:23,690 --> 00:14:28,610
+ما بين الجهاز وما بين العين إذا هذا الجهاز لم يعقم
+
+182
+00:14:28,610 --> 00:14:36,710
+بين مريض و آخر فسوف يكون أداة لنقل منه العدوى وهذا
+
+183
+00:14:36,710 --> 00:14:40,090
+النوع من العدوى ما نسميه في الطب هي atrogenic
+
+184
+00:14:40,090 --> 00:14:45,330
+infectionhiatrogenic يعني نقلت من خلال التداوي، من
+
+185
+00:14:45,330 --> 00:14:50,730
+خلال الفحص، من خلال أدوات الأطباء أو ممارسات اللي
+
+186
+00:14:50,730 --> 00:14:54,910
+هم الأطباء في المستشفيات، إيش اسمها؟ hiatrogenic،
+
+187
+00:14:54,910 --> 00:14:59,910
+هتمروا معانا بتحيل المصطلح كمان شويةحكينا عن
+
+188
+00:14:59,910 --> 00:15:02,690
+الفكرة All are root common in young children and
+
+189
+00:15:02,690 --> 00:15:06,710
+their families. Many species of animals are
+
+190
+00:15:06,710 --> 00:15:09,490
+infected by strains of adenovirus but these
+
+191
+00:15:09,490 --> 00:15:12,870
+strains are not pathogenic to human يعني الإنسان
+
+192
+00:15:12,870 --> 00:15:19,210
+والحيوان اللي هم سردات مختلفة من هذا ال virusممكن
+
+193
+00:15:19,210 --> 00:15:23,890
+ال adenovirus يعمل epidemic أو outbreaks على الرغم
+
+194
+00:15:23,890 --> 00:15:29,630
+من أننا نوصفه على انه endemic ايش يعني endemic؟
+
+195
+00:15:29,630 --> 00:15:33,850
+endemic يعني مستوطن يعني موجود worldwide في كل
+
+196
+00:15:33,850 --> 00:15:38,600
+العالم في adenovirusلكن قد يحدث ان يكون فيه
+
+197
+00:15:38,600 --> 00:15:43,880
+outbreaks مثال على فئة مهمة بيحدث فيها outbreaks
+
+198
+00:15:43,880 --> 00:15:47,360
+اللي هم ال military recruits ال military recruits
+
+199
+00:15:47,360 --> 00:15:53,300
+اللي هم مين؟ المجندين الجدد طبعا في ناس زي
+
+200
+00:15:53,300 --> 00:15:57,020
+المجندين الجدد بيسموهم college students اللي هم
+
+201
+00:15:57,020 --> 00:16:02,040
+طلاب الجامعة طلاب الجامعةليش الـ military recruits
+
+202
+00:16:02,040 --> 00:16:07,240
+و طلاب الجامعات بالذات عندهم قابلية للانتشار فيه
+
+203
+00:16:07,240 --> 00:16:12,180
+أو انتشار الأمراض بشكل كبير؟ في معظم الدول .. في
+
+204
+00:16:12,180 --> 00:16:17,700
+معظم الدول التجنيد بيكون مركزي بمعنى أنه بييجي من
+
+205
+00:16:17,700 --> 00:16:23,380
+القرى و من المدن الأشخاص على مكان بعيدالان بيئة
+
+206
+00:16:23,380 --> 00:16:26,760
+جديدة انتقال من بيئة ال home اللي هو البيت اللي هي
+
+207
+00:16:26,760 --> 00:16:30,720
+الأم والأب و ال family و الأصدقاء إلى بيئة جديدة
+
+208
+00:16:30,720 --> 00:16:35,460
+ما بيعرفوا حالة فيها غالبا بيئة غريبة عليهم طريقة
+
+209
+00:16:35,460 --> 00:16:40,300
+التناول أطعمها مختلفة الغذاء بتغير بيقدم لهم أغذية
+
+210
+00:16:40,300 --> 00:16:43,630
+غير اللي كانوا ياخدوها في البيتفبيكونوا under
+
+211
+00:16:43,630 --> 00:16:49,090
+stress متوترين التغذية تبعتهم مش تمام كويس home
+
+212
+00:16:49,090 --> 00:16:55,970
+sick شعرين بالحنين الى الاهل و المكان و في نفس
+
+213
+00:16:55,970 --> 00:17:02,130
+الوجد they are enclosed يعني in crowded conditions
+
+214
+00:17:02,130 --> 00:17:08,510
+يعني ظروف من الازدحان من الازدحان فانت ما نعم خافي
+
+215
+00:17:08,510 --> 00:17:12,890
+ضرر ننتج عن الأسباب اللي ذكرتهابالاضافة إلى انهم
+
+216
+00:17:12,890 --> 00:17:16,670
+اصلا crowded وبتالي امكانية الانتقال بينهم بتكون
+
+217
+00:17:16,670 --> 00:17:20,430
+امكانية عالية هذا الكلام بيتطبق على مين؟ على
+
+218
+00:17:20,430 --> 00:17:25,110
+الجنود وطلاب الجامعة نفس القصةاحنا محظوظين إنه
+
+219
+00:17:25,110 --> 00:17:28,890
+جامعاتنا جامنة تمام؟ سواء حتى لو كنا في رفح أو في
+
+220
+00:17:28,890 --> 00:17:32,870
+بيت حنون لكن بالنسبة إن الجامعة قريبة جدا بالنسبة
+
+221
+00:17:32,870 --> 00:17:37,230
+لما كان ساكن في معظم الدول التانية بيسافر من ولاية
+
+222
+00:17:37,230 --> 00:17:40,730
+لولاية أو من مدينة إلى مدينة حتى يذهب إلى الجامعة
+
+223
+00:17:40,730 --> 00:17:45,030
+وبالتالي برضه بيكون بينطبق عليه ما ينطبق على ال
+
+224
+00:17:45,030 --> 00:17:47,630
+military recruit اللي احنا ذكرناهم قبل قليل
+
+225
+00:17:52,340 --> 00:17:56,340
+زي ما ذكرت انا انه certain types are associated
+
+226
+00:17:56,340 --> 00:18:00,700
+with specific syndrome مثلا والارقام اللي مذكورة
+
+227
+00:18:00,700 --> 00:18:04,780
+هنا مش للحفظ وانما هي للتمثيل وهي ارقام حقيقية
+
+228
+00:18:04,780 --> 00:18:08,280
+حقيقة لكن مش هان .. يعني نطلب منكم تحفظوهم
+
+229
+00:18:08,280 --> 00:18:13,320
+للاختبار تلاتة اربعة سبعة واحد وعشرين مربوطين بمين
+
+230
+00:18:13,320 --> 00:18:16,660
+بال respiratory disease احفظوهم كويس هدول الاربعة
+
+231
+00:18:16,660 --> 00:18:20,100
+الآن .. الآن احفظوهم احنا في لوحة تانية هنستفيد
+
+232
+00:18:20,100 --> 00:18:25,300
+منهمتمنية و تسعة و عشر كيراتو كوندكتفيتس أحداشر و
+
+233
+00:18:25,300 --> 00:18:28,900
+واحد و عشرين hemorrhagic cystitis أربعين و واحد و
+
+234
+00:18:28,900 --> 00:18:33,940
+أربعين بسبب infantile gastroenteritis إذا في عندي
+
+235
+00:18:33,940 --> 00:18:37,300
+سلالات بتعمل gastroenteritis سلالات بتعمل
+
+236
+00:18:37,300 --> 00:18:40,020
+hemorrhagic cystitis سلالات بتعمل كيراتو
+
+237
+00:18:40,020 --> 00:18:43,600
+كوندكتفيتس و بتعمل في الأخر اللي هو الأول واحدة ال
+
+238
+00:18:43,600 --> 00:18:48,980
+respiratory disease طبعا لحظة especially in من
+
+239
+00:19:05,710 --> 00:19:10,510
+Pathogenesis والإميونية الانينوفيروس انفكت
+
+240
+00:19:10,510 --> 00:19:17,380
+الميكوزل ابيثيليا معفن من عدة أعضاء كثيرلكن الـ
+
+241
+00:19:17,380 --> 00:19:20,760
+target المستدف هو مين؟ الـ epithelial تبع هذه
+
+242
+00:19:20,760 --> 00:19:23,540
+الأورجان زي ال respiratory tract وال
+
+243
+00:19:23,540 --> 00:19:26,080
+gastrointestinal tract زائد اللي هو ال
+
+244
+00:19:26,080 --> 00:19:31,580
+conjunctivus المناعة مرتبطة ب neutralizing
+
+245
+00:19:31,580 --> 00:19:34,720
+antibody وماذا يقصد neutralizing antibody يا بنات؟
+
+246
+00:19:34,720 --> 00:19:38,140
+هو ال antibody اللي هيرتبط بال binding site، مين
+
+247
+00:19:38,140 --> 00:19:40,400
+ال binding site في هذه الحالة؟ اللي هو ال fibers
+
+248
+00:19:40,400 --> 00:19:45,780
+اللي احنا شفناه في أول المحارةand it is type
+
+249
+00:19:45,780 --> 00:19:52,000
+specific and life long يعني بيعطينا حماية لمدى
+
+250
+00:19:52,000 --> 00:19:56,940
+الحياة، مدى الحياةIn addition to acute infection
+
+251
+00:19:56,940 --> 00:20:00,540
+leading to death of cells, adenovirus causes
+
+252
+00:20:00,540 --> 00:20:07,720
+latent infection. إذن ليس ليس ال herpes viruses
+
+253
+00:20:07,720 --> 00:20:12,400
+وحدها اللي بتعمل latent infection، أيضا حضرة ال
+
+254
+00:20:12,400 --> 00:20:16,250
+adenovirus بتعمل latent infectionوين بيعمل
+
+255
+00:20:16,250 --> 00:20:19,690
+latency؟ في الـTonsillar tissue عشان هيك ممكن يصير
+
+256
+00:20:19,690 --> 00:20:23,410
+فينا repeated infection في الـTonsils وفي
+
+257
+00:20:23,410 --> 00:20:29,750
+الـAdenoid tissue والحقيقة أن الفيروس عزل لأول مرة
+
+258
+00:20:29,750 --> 00:20:35,950
+في العام 1953 من Adenoids من غدر لمفاوية في رسم
+
+259
+00:20:35,950 --> 00:20:40,870
+الإنسان وسمي ادينو فيروس لإنه عزل من هذه
+
+260
+00:20:40,870 --> 00:20:43,530
+الـAdenoid cells أو الـAdenoid tissue
+
+261
+00:20:46,710 --> 00:20:49,530
+من الـ clinical findings للأمراض اللي احنا شوفناها
+
+262
+00:20:49,530 --> 00:20:52,430
+قبل قليل مثلا في ال upper respiratory tract
+
+263
+00:20:52,430 --> 00:20:57,390
+infection ممكن نلاقي pharyngitis التها في الحلق،
+
+264
+00:20:57,390 --> 00:21:01,610
+pharyngoconductivitis أو pharyngoconductive fever
+
+265
+00:21:01,610 --> 00:21:07,710
+هم مصحوبة بالتهاب في ال pharynx يعني ال
+
+266
+00:21:07,710 --> 00:21:12,670
+pharyngitis بالاضافة إلى احمرار العين and acute
+
+267
+00:21:12,670 --> 00:21:17,230
+respiratory diseaseكلمة acute يعني العراض بتكون
+
+268
+00:21:17,230 --> 00:21:20,490
+prominent و واضحة و ال onset بتكون rapid
+
+269
+00:21:20,490 --> 00:21:24,510
+characterized by fever, sore throat, choroisa،
+
+270
+00:21:24,510 --> 00:21:28,230
+choroisa معناها runny nose يعني الأنف بيكون بيسيل
+
+271
+00:21:28,230 --> 00:21:33,770
+تسيل من الأنف and conductive itis في ال lower
+
+272
+00:21:33,770 --> 00:21:37,830
+respiratory tract فينا two conditions bronchitis
+
+273
+00:21:37,830 --> 00:21:41,130
+and atypical pneumonia وكل كوا بتعرفوا pneumonia
+
+274
+00:21:41,130 --> 00:21:46,370
+معناها ذات الرئةليش قدفنا جملة atypical عشان
+
+275
+00:21:46,370 --> 00:21:49,790
+نميزها عن ال pneumonia caused by common بكتير زي
+
+276
+00:21:49,790 --> 00:21:53,710
+Stratococcus pneumonia وكلمة atypical pneumonia لا
+
+277
+00:21:53,710 --> 00:21:58,290
+تعني ان انا بس بتكلم عن ال adenovirus هناك مجموعة
+
+278
+00:21:58,290 --> 00:22:01,950
+كبيرة من الميكروبات اللي يمكن تسبب atypical
+
+279
+00:22:01,950 --> 00:22:05,670
+pneumonia hematuria and dysuria
+
+280
+00:22:10,220 --> 00:22:14,560
+العرضين المهمين والبرزين في الهيموراجيك سيستايتس
+
+281
+00:22:14,560 --> 00:22:15,920
+في الهيموراجيك سيستايتس في الهيموراجيك سيستايتس
+
+282
+00:22:15,920 --> 00:22:21,220
+طبعا في ال gastroenteritis غالبا بتكون non bloody
+
+283
+00:22:21,220 --> 00:22:21,920
+دياريا
+
+284
+00:22:26,400 --> 00:22:29,200
+دياريا في الأطفال اللي بنقسمها أو دياريا بشكل عام
+
+285
+00:22:29,200 --> 00:22:33,660
+بنقسمها لجسمين bloody لما تكون مصحوبة بدم و non
+
+286
+00:22:33,660 --> 00:22:37,700
+-bloody فهذا التصنيف فقط لووجود الدم أو عدم وجود
+
+287
+00:22:37,700 --> 00:22:41,820
+الدم لأن في consequences لووجود الدم أو عدم وجود
+
+288
+00:22:41,820 --> 00:22:45,100
+الدم فإذا bloody دياريا و non-bloody دياريا إذا
+
+289
+00:22:45,100 --> 00:22:49,540
+هذه الأدينو بايروس مش بيعمل non-bloody دياريا لمن؟
+
+290
+00:22:49,540 --> 00:22:53,700
+للأطفال اللي عمرهم كده أقل من سنتين إيش بنسميهم
+
+291
+00:22:53,700 --> 00:22:56,850
+الأطفال اللي عمرهم أقل من سنتين؟Infants اللي هم
+
+292
+00:22:56,850 --> 00:23:01,630
+الرضا تمام؟ اللي جنا بينطبق عليهم القول بإنهم هم
+
+293
+00:23:01,630 --> 00:23:05,850
+بالفعل الفئة الأكتر عرضة للفكرة ال oral من
+
+294
+00:23:05,850 --> 00:23:10,050
+الممارسات اللي هي الأطفال بيمارسوها من خلال جنا
+
+295
+00:23:10,050 --> 00:23:16,030
+تتعرف على الأشياء من خلال التذوق Most adenovirus
+
+296
+00:23:16,030 --> 00:23:20,890
+infections resolve spontaneously زي ما ذكرنا بتروح
+
+297
+00:23:20,890 --> 00:23:24,990
+لحالها العدوApproximately half of the adenovirus
+
+298
+00:23:24,990 --> 00:23:32,450
+infection are asymptomatic قد
+
+299
+00:23:32,450 --> 00:23:36,250
+تكون
+
+300
+00:23:36,250 --> 00:23:43,110
+لأسباب غير أن هو فيروس ضعيف سأعطيكم سؤال بالان
+
+301
+00:23:43,110 --> 00:23:47,990
+تفكروا فيه إذا كان هناك عضو من الذين يعملوا مرض في
+
+302
+00:23:47,990 --> 00:23:52,550
+الـ Respiratory tractStrain من اللي بيعمل
+
+303
+00:23:52,550 --> 00:23:56,090
+infection للـ respiratory tract دخل إلى ال
+
+304
+00:23:56,090 --> 00:24:00,580
+gastrointestinal tractهل هيعمل infection أو مش
+
+305
+00:24:00,580 --> 00:24:03,820
+هيعمل infection؟ بيعمل infection لكن مش بيعمل
+
+306
+00:24:03,820 --> 00:24:08,720
+infection asymptomatic وهذا أساس ال vaccine احنا
+
+307
+00:24:08,720 --> 00:24:13,060
+لما نعمل vaccine بنعمل vaccine لل respiratory لل
+
+308
+00:24:13,060 --> 00:24:18,380
+respiratory strains بس بنعطيها عبر مين؟ عبر الفم
+
+309
+00:24:18,380 --> 00:24:20,980
+عشان تروح على ال intestine و تعمل infection
+
+310
+00:24:20,980 --> 00:24:27,570
+asymptomatic infection إذا قد تكون fifty percentمن
+
+311
+00:24:27,570 --> 00:24:33,330
+الإصابات بالـ adenovirus are asymptomatic لهذا
+
+312
+00:24:33,330 --> 00:24:37,310
+السبب و ليس بسبب أن الفيروس ضعيف و غير قادر على أن
+
+313
+00:24:37,310 --> 00:24:41,870
+يعمل عدوة انه دخل في مكان غير محبب له فعمل
+
+314
+00:24:41,870 --> 00:24:45,710
+infection لكن هذه ال infection كانت asymptomatic
+
+315
+00:24:45,710 --> 00:24:52,810
+ال lab diagnosis الحقيقة أنه .. يعني قلتلكوا هذا
+
+316
+00:24:52,810 --> 00:24:58,160
+الفيروسمش كتير مهتمين فيه في العالم إلا في جزئيته
+
+317
+00:24:58,160 --> 00:25:00,680
+اللي هو ال military recruits وعمليله vaccine لكن
+
+318
+00:25:00,680 --> 00:25:04,520
+ال diagnosis بتاعه ممكن يتم من خلال شغلتان
+
+319
+00:25:04,520 --> 00:25:10,080
+رئيسيتين الأولى انه نعمل عزل للفيروس في cell
+
+320
+00:25:10,080 --> 00:25:14,480
+culture والثانية من خلال ال serology fourfold
+
+321
+00:25:14,480 --> 00:25:20,960
+increase in antibody tighter فاكرينها ال IGGاليوم
+
+322
+00:25:20,960 --> 00:25:25,560
+وبعد عشر أيام وزيادة أربعة أضعاف أو أكتر في
+
+323
+00:25:25,560 --> 00:25:29,380
+الـTiter تعتبر Diagnostic والفحصين المستخدمين في
+
+324
+00:25:29,380 --> 00:25:33,980
+السيرولوجيا الأكتر شيوعا هم الـComplement Fixation
+
+325
+00:25:33,980 --> 00:25:38,260
+والـHeme Agglutination Inhibition بالنسبة
+
+326
+00:25:38,260 --> 00:25:44,700
+لـTreatment كما ذكرنا لكم مافيش Antiviral Therapy
+
+327
+00:25:44,700 --> 00:25:51,650
+لهذا الفيروس بالنسبة لـ Preventionتعرف تطلع على
+
+328
+00:25:51,650 --> 00:25:55,730
+الـ Mode of Transmission الـ Mode of Transmission
+
+329
+00:25:55,730 --> 00:26:00,810
+كيف بينتقل الفيروس؟ بينتقل عبر طريق الفيكرورال
+
+330
+00:26:00,810 --> 00:26:06,450
+بينتقل عبر طريق اللي هو ال Respiratory وبينتقل عبر
+
+331
+00:26:06,450 --> 00:26:10,010
+إياتروجينك وين الإياتروجينك؟ هلعظني في المكان هذا؟
+
+332
+00:26:10,010 --> 00:26:16,670
+إياتروجينك طب إذا إياتروجينك كيف بدنا نمنع انتقال
+
+333
+00:26:16,670 --> 00:26:23,000
+العدوى؟بدنا نمارس ممارسات aseptic technique strict
+
+334
+00:26:23,000 --> 00:26:27,920
+aseptic technique لكل من يتعامل مع ال eye عشان ما
+
+335
+00:26:27,920 --> 00:26:33,440
+ننقلش الميكروب من شخص إلى شخص آخر هذه نقطة كتير
+
+336
+00:26:33,440 --> 00:26:38,300
+مهمة طب بالنسبة لل Respiratory نرمنا نفس الكح صعب
+
+337
+00:26:38,300 --> 00:26:42,840
+ولا لأ؟ إذا الأشخاص الأكثر أرضة احنا كنا نقول لكوا
+
+338
+00:26:42,840 --> 00:26:46,920
+عنهم مين هم ال military recruits إذا نفتنقهم بعمل
+
+339
+00:26:46,920 --> 00:26:52,580
+vaccineالان الفاكسين هذا مكون من ثلاث سلالات اربعة
+
+340
+00:26:52,580 --> 00:26:56,120
+و سبعة و جداش و واحد و عشرين و انا اقول لك تذكروهم
+
+341
+00:26:56,120 --> 00:27:00,460
+من مين من لوحات سابقة طبعا خدوا بالكوا في فاكسينز
+
+342
+00:27:00,460 --> 00:27:05,740
+كتيرة معمولة لكن هذا هو الأشهر على الإطلاق في اللي
+
+343
+00:27:05,740 --> 00:27:09,500
+هو هذا المجال الان طبعا من كلامي انا فهمت ان
+
+344
+00:27:09,500 --> 00:27:14,360
+الفاكسين بيحتوي على مين؟ على ثلاثة ارجو منكم لا
+
+345
+00:27:14,360 --> 00:27:19,140
+تفهموش هذا الكلام افهموا ان كل واحد منهم لحاللما
+
+346
+00:27:19,140 --> 00:27:24,020
+حطوهم مع بعض، واحد عمل interference مع التانين،
+
+347
+00:27:24,020 --> 00:27:28,260
+بمعنى إن الجسم كوّن أجسام مضادة لو واحد بس ماكوّنش
+
+348
+00:27:28,260 --> 00:27:32,840
+الأجسام ماكوّنش التانين الباقين، فإيش صنتجنا؟ إن
+
+349
+00:27:32,840 --> 00:27:37,220
+وجودهم مع بعض بيعمل interference مع بعض، وطبعا هذا
+
+350
+00:27:37,220 --> 00:27:41,550
+ممكن يكون منطقي، عارفين ليش؟لأن الفيروس لما بيدخل
+
+351
+00:27:41,550 --> 00:27:46,750
+داخل خلية كويس و بيعملها infection غالبا بيوفر
+
+352
+00:27:46,750 --> 00:27:52,130
+immunity للخلية من other viruses من other viruses
+
+353
+00:27:52,130 --> 00:27:59,750
+فلذلك تُعطى هذه التطايمات على ثلاث جرعات متباعدة
+
+354
+00:27:59,750 --> 00:28:04,050
+على ثلاث جرعات متباعدة كل ما ما على حد يبقى
+
+355
+00:28:04,050 --> 00:28:08,440
+كابسولة كابسولة كابسولةطب بتتكلم عن كابسول احنا
+
+356
+00:28:08,440 --> 00:28:13,440
+بتتمر عبر مين؟ عبر المعيدة، طب والمعيدة شو بتعمل؟
+
+357
+00:28:13,440 --> 00:28:17,720
+حامضية و قوية و بتقتل البكتيريات و تقتل الفيروسات؟
+
+358
+00:28:17,720 --> 00:28:22,200
+تقتل الفيروسات، لذلك يُعطى في كابسولة خاصة بيسموها
+
+359
+00:28:22,200 --> 00:28:29,910
+Intricated Capsuleيعني بتحميها من وين؟ من ال acid
+
+360
+00:28:29,910 --> 00:28:34,290
+أو الحامض تبع المعدة وبالتالي بتوصلها لل intestine
+
+361
+00:28:34,290 --> 00:28:38,550
+وهناك في ال intestine بالذوب وبتبدأ الفيروسات تعمل
+
+362
+00:28:38,550 --> 00:28:43,310
+mild infection أو asymptomatic infection بالاخرى
+
+363
+00:28:43,310 --> 00:28:47,190
+وبتوفر مناقة ضد هذه السلالات اللي احنا ذكرنا
+
+364
+00:28:55,900 --> 00:28:57,560
+الفيروس التاني في السلسلة اللي هو ال
+
+365
+00:28:57,560 --> 00:29:01,800
+papillomavirus والفيروس التاني في السلسلة اللي هو
+
+366
+00:29:01,800 --> 00:29:01,800
+ال papillomavirus والفيروس التاني في السلسلة اللي
+
+367
+00:29:01,800 --> 00:29:02,480
+هو ال papillomavirus والفيروس التاني في السلسلة
+
+368
+00:29:02,480 --> 00:29:04,340
+اللي هو ال papillomavirus والفيروس التاني في
+
+369
+00:29:04,340 --> 00:29:05,280
+السلسلة اللي هو الفيروس التاني في السلسلة اللي هو
+
+370
+00:29:05,280 --> 00:29:06,440
+الفيروس التاني في السلسلة اللي هو الفيروس التاني
+
+371
+00:29:06,440 --> 00:29:06,780
+في السلسلة اللي هو الفيروس التاني في السلسلة اللي
+
+372
+00:29:06,780 --> 00:29:08,540
+هو الفيروس التاني في السلسلة اللي هو الفيروس
+
+373
+00:29:08,540 --> 00:29:08,920
+التاني في السلسلة اللي هو الفيروس التاني في
+
+374
+00:29:08,920 --> 00:29:12,940
+السلسلة اللي هو الفيروس التاني في السلسلة اللي هو
+
+375
+00:29:12,940 --> 00:29:18,620
+الفيروس التاني في السلسلة اللي هو الفيروس
+
+376
+00:29:19,660 --> 00:29:24,280
+Particle يعني اللي طلع هذا الشكل هو software
+
+377
+00:29:24,280 --> 00:29:28,540
+برنامج حاسوب لكن طلع الصورة الحقيقية under the
+
+378
+00:29:28,540 --> 00:29:32,860
+electron microscope أليست قريبة؟ قريبة لكن غير
+
+379
+00:29:32,860 --> 00:29:36,340
+ملونة يعني ماممكن يكون لو أحنا أخدنا صورة ملونة
+
+380
+00:29:36,340 --> 00:29:39,060
+للفيروس بال electron microscope someday اللي جيه
+
+381
+00:29:39,060 --> 00:29:46,680
+أجمل مما ال computer صور طيب human papilloma virus
+
+382
+00:29:46,680 --> 00:29:51,770
+أو HPVcauses papillomas والـ papillomas are benign
+
+383
+00:29:51,770 --> 00:29:56,510
+tumors، benign يعني حميدة، مش malignant، خبيثة،
+
+384
+00:29:56,510 --> 00:30:02,290
+عكسها، of squamous cells وبالتالي بالعرب البسيط،
+
+385
+00:30:02,290 --> 00:30:08,550
+warts on the skin، يعني تقليل على الجلم، لكن هناك
+
+386
+00:30:08,550 --> 00:30:15,370
+استثناءبعض الـ HPV-Types، خصوصًا الـType 16 و18،
+
+387
+00:30:15,370 --> 00:30:19,730
+يمكن أن يسببوا كرسينوما في الصحراء والرأس، إذا في
+
+388
+00:30:19,730 --> 00:30:26,610
+سلالات خاصة 16 و18، إيش بتسبب كرسينوما؟ إذا
+
+389
+00:30:26,610 --> 00:30:30,570
+الـPapilloma virus could be classified as an
+
+390
+00:30:30,570 --> 00:30:39,530
+oncovirusالـ HPV .. أفضل الـ HHV8 الهيومان هيربس
+
+391
+00:30:39,530 --> 00:30:45,070
+فيروس تايب ات جونه اونكو فيروس ايش كمان فيروسات؟
+
+392
+00:30:45,070 --> 00:30:48,750
+ابشتين بار فيروس نازوفارنجال كارسينوما باريكتس
+
+393
+00:30:48,750 --> 00:30:52,290
+لينفومة other lymphomas مظبوط؟ يبقى في عندي مجموعة
+
+394
+00:30:52,290 --> 00:30:57,070
+من الفيروسات ارتبطت ارتباط واثق بمين؟ بالكانسر
+
+395
+00:30:57,070 --> 00:31:01,880
+واحد منهم ال papilloma virusفي الجدول اللي أعطته
+
+396
+00:31:01,880 --> 00:31:05,720
+في أول المحاضرة في آخر عمود كان فيه سؤال هل هناك
+
+397
+00:31:05,720 --> 00:31:09,720
+vaccine أم لا؟ وقلنا لكوا اشطبوا كفي بالخطأ مكتوبة
+
+398
+00:31:09,720 --> 00:31:14,840
+no لكن قلنا انه في yes وبنفتخر دوما بإنه العلم
+
+399
+00:31:14,840 --> 00:31:19,740
+أنتج vaccine ضد السرطان هو الواقع مش ضد السرطان ضد
+
+400
+00:31:19,740 --> 00:31:23,780
+الفيروس اللي هو ال papilloma virus اللي بيسبب ال
+
+401
+00:31:23,780 --> 00:31:25,520
+cervix و ال penile cancer
+
+402
+00:31:28,500 --> 00:31:30,900
+أحنا في ال .. ال .. الفيروس اللي السابق قلنالكوا
+
+403
+00:31:30,900 --> 00:31:33,900
+راجزوا على كلمة linear double-stranded linear هنا
+
+404
+00:31:33,900 --> 00:31:37,720
+double-stranded إيش؟ circular DNA and an
+
+405
+00:31:37,720 --> 00:31:41,780
+icosahedral nucleocapsin واضح إن احنا بتتكلم عن
+
+406
+00:31:41,780 --> 00:31:46,660
+شكل جريب من بعض لكن ال .. ال .. ال .. المادة
+
+407
+00:31:46,660 --> 00:31:51,340
+الوراثية مختلفة بإنه double-stranded linear هناك
+
+408
+00:31:51,340 --> 00:31:55,660
+وهنا double-stranded circleتعالى ننظر الان على
+
+409
+00:31:55,660 --> 00:32:00,760
+الفيروس هذا كيف يسبب كانسر هنا two of the proteins
+
+410
+00:32:00,760 --> 00:32:06,720
+بسمهم E6 وE7 E6 E7 are implicated in
+
+411
+00:32:06,720 --> 00:32:11,180
+carcinogenesis implicated يعني متهلة او متورطة
+
+412
+00:32:11,180 --> 00:32:17,630
+متورطة في ال carcinogenesis هناكTumor suppressor
+
+413
+00:32:17,630 --> 00:32:23,250
+genes مشهورين جدا و واحد اسمه B53 و واحد اسمه
+
+414
+00:32:23,250 --> 00:32:26,750
+Retinoblastoma و Retinoblastoma مار معانا ..
+
+415
+00:32:26,750 --> 00:32:32,270
+Retinoblastoma مار معانا في ال human herpes virus
+
+416
+00:32:32,270 --> 00:32:37,750
+type 8 تمام؟ و قلنالكوا كيف بيشتغل، الآن ال E6 و
+
+417
+00:32:37,750 --> 00:32:42,690
+E7 بيطلقوا بروتينات بيعملوا inactivation لهذه
+
+418
+00:32:42,690 --> 00:32:48,140
+الجيناتلما بيعملوا inactivation لل P53 و للريتنو
+
+419
+00:32:48,140 --> 00:32:51,340
+بلاستوما genes، ايش تقول انها وظيفتهم؟ tumor
+
+420
+00:32:51,340 --> 00:32:54,800
+suppressor، هم اللي موقفين جينات ال cancer انهم
+
+421
+00:32:54,800 --> 00:33:00,760
+يشتغلوا، شيلتهم و عطلتهم انا، بطلوا جادرين يعملوا
+
+422
+00:33:00,760 --> 00:33:05,120
+suppression لمين؟ لل cancer، ف cancer will develop
+
+423
+00:33:06,000 --> 00:33:11,280
+وصل الصورة إذا كيف .. كيف لل human papilloma virus
+
+424
+00:33:11,280 --> 00:33:15,940
+أن يسبب ال cancer من خلال ال E6 و ال E7 اللي بيعمل
+
+425
+00:33:15,940 --> 00:33:19,400
+ال inactivation لكل من اللي هم ال P53 و ال
+
+426
+00:33:19,400 --> 00:33:22,380
+retinoplastoma و انها tumor suppressor genes
+
+427
+00:33:25,590 --> 00:33:28,490
+There are at least one hundred types of papilloma
+
+428
+00:33:28,490 --> 00:33:33,930
+viruses Classified
+
+429
+00:33:33,930 --> 00:33:37,530
+primarily on the basis of DNA restriction fragment
+
+430
+00:33:37,530 --> 00:33:38,190
+analysis
+
+431
+00:33:55,530 --> 00:34:01,250
+بقولنا إنه فيه هناك يعني ميل ل certain types to
+
+432
+00:34:01,250 --> 00:34:03,630
+infect certain tissues زي ما شوفنا قبل شويه احنا
+
+433
+00:34:03,630 --> 00:34:06,610
+برضه في القدي نوفايروس شوفنا سلالات بتصيب ال
+
+434
+00:34:06,610 --> 00:34:08,670
+respiratory tract شوفنا سلالات بتصيب ال
+
+435
+00:34:08,670 --> 00:34:12,190
+gastrointestinal tract شوفنا سلالات بتصيب المثالة
+
+436
+00:34:12,190 --> 00:34:16,130
+صح ولا لأ وبالتالي نفس الشيء مثلا بقولنا إن skin
+
+437
+00:34:16,130 --> 00:34:23,640
+warts are caused by HPV1من واحد إلى أربعة هدولة
+
+438
+00:34:23,640 --> 00:34:30,100
+كلمة HPV 1 to through HPV 4 يعني 2, 3 و 4 و الـ as
+
+439
+00:34:30,100 --> 00:34:34,220
+genital warts اللي مرتبطة بالعضايا التناثلية are
+
+440
+00:34:34,220 --> 00:34:39,300
+usually caused by HPV 6 و HPV 11 إذا الفاكسين
+
+441
+00:34:39,300 --> 00:34:43,960
+هيكون ضمنينالفاكسين اللي حكينا عنه قبل قليل هيكون
+
+442
+00:34:43,960 --> 00:34:48,720
+ضد اللي هم الـ strains اللي بتسبب جونة الـ genital
+
+443
+00:34:48,720 --> 00:34:52,740
+warts اللي هي ممكن تؤدي إلى الـ cancer طلعوا الآن
+
+444
+00:34:52,740 --> 00:34:58,500
+approximately 30 types من المية of HPV انفكس الـ
+
+445
+00:34:58,500 --> 00:34:59,560
+genital tract
+
+446
+00:35:02,640 --> 00:35:06,220
+Papilloma viruses برضه من الجدول البسيط اللى احنا
+
+447
+00:35:06,220 --> 00:35:09,720
+قعدنا في اول المحاضرة بتنتقل عن طريقين اللى هو
+
+448
+00:35:09,720 --> 00:35:14,680
+skin to skin contact و sexual contact skin to skin
+
+449
+00:35:14,680 --> 00:35:18,660
+contact and by genital contact genital warts are
+
+450
+00:35:18,660 --> 00:35:21,560
+among the most common sexually transmitted disease
+
+451
+00:35:21,560 --> 00:35:27,040
+يعني احنا طبعا انتوا عارفين لما احنا بنقول STD
+
+452
+00:35:27,040 --> 00:35:30,940
+sexually transmitted diseases مجموعة من الأمراض
+
+453
+00:35:30,940 --> 00:35:37,760
+الجنوريةclamydia, syphilis, herpes virus type 2،
+
+454
+00:35:37,760 --> 00:35:44,960
+مظبوط، هي أنها من ال human papilloma virus ال HPV
+
+455
+00:35:44,960 --> 00:35:48,920
+و لما أنا أقول one of the most common يبقى الآن
+
+456
+00:35:48,920 --> 00:35:53,320
+نسبة حدوثه في الأعمار الجنسية جمالها ايضا مرتفعة
+
+457
+00:35:53,320 --> 00:35:56,860
+طبعا ال most common انا بقول one of the most
+
+458
+00:35:56,860 --> 00:36:01,740
+common لكن مين ال most common؟الكلاميديا number
+
+459
+00:36:01,740 --> 00:36:07,940
+one بيجي وراها الجنورية في الأمراض ال STD لكن بشكل
+
+460
+00:36:07,940 --> 00:36:11,460
+عام كل الأمراض اللي بتتقل عن طريق الجنس في العالم
+
+461
+00:36:11,460 --> 00:36:17,520
+الغربي هي الآن بنسبة مرتفعة وعاليةSkin warts are
+
+462
+00:36:17,520 --> 00:36:20,320
+more common in children and young adults and tend
+
+463
+00:36:20,320 --> 00:36:25,440
+to regress in older adults يعني بتكون اللي هي ال
+
+464
+00:36:25,440 --> 00:36:30,120
+skin warts بتكون نسبتها أعلى في الأطفال و بتجل مع
+
+465
+00:36:30,120 --> 00:36:34,220
+الكبار لكن طبعا عكس هيكون مين اللي هو ال sexually
+
+466
+00:36:34,220 --> 00:36:39,690
+transmitted HPV ممكن ينتقل من ال infected motherto
+
+467
+00:36:39,690 --> 00:36:42,310
+the neonate during childbirth يعني إذا احنا بنقول
+
+468
+00:36:42,310 --> 00:36:47,910
+هو genital يبقى ممكن ينتقل من الأم إلى المولود
+
+469
+00:36:47,910 --> 00:36:50,690
+causes warts in the mouth and the respiratory
+
+470
+00:36:50,690 --> 00:36:54,170
+tract يعني حتى داخل الفم وفي الجهاز التنفسي
+
+471
+00:36:54,170 --> 00:36:59,480
+especially in the larynx of the infantmany species
+
+472
+00:36:59,480 --> 00:37:03,900
+of animals are infected with their own types of
+
+473
+00:37:03,900 --> 00:37:07,040
+papilloma viruses لكن لا تنتقل إلى مين؟ إلى
+
+474
+00:37:07,040 --> 00:37:15,460
+الإنسان، ولا تعتبر مصدر عدوى مهم للإنسان.بعطي
+
+475
+00:37:15,460 --> 00:37:18,480
+genesis and immunity كيف لهذا الفيروس أن يحدث
+
+476
+00:37:18,480 --> 00:37:23,480
+المرض؟ وإيش ال immunity اللي بيكون الإنسان ضد هذا
+
+477
+00:37:23,480 --> 00:37:25,600
+المرض؟
+
+478
+00:37:27,110 --> 00:37:31,650
+Papilloma viruses infect squamous epithelial cells
+
+479
+00:37:31,650 --> 00:37:34,930
+and induce within those cells a characteristic
+
+480
+00:37:34,930 --> 00:37:37,110
+cytoplasmic vacuole
+
+481
+00:37:46,750 --> 00:37:52,470
+يعني مرتبطة، مميزة، علامة مميزة لهذا ال .. ال ..
+
+482
+00:37:52,470 --> 00:37:55,910
+ال .. ال .. الفيروس وهذه الـ vacculated cell
+
+483
+00:37:55,910 --> 00:38:03,740
+بيسموهاوهي coil sites و هي hallmark of infection
+
+484
+00:38:03,740 --> 00:38:07,680
+by these viruses فاكرين لما مرة قلنا احدى ال owls
+
+485
+00:38:07,680 --> 00:38:14,460
+eye لل CMV و لما قلنا نجري bodies لل rabies virus
+
+486
+00:38:14,460 --> 00:38:19,460
+ايضا ال coil sites هذه hallmark لمين؟ لل papilloma
+
+487
+00:38:19,460 --> 00:38:20,160
+virus
+
+488
+00:38:25,840 --> 00:38:30,140
+معظم الحكومات هي حميدة ولا تتطور إلى انها تكون
+
+489
+00:38:30,140 --> 00:38:36,100
+خبيثة، لكن الانفكار الـ HPV هو مرتبط بالكرسينومات
+
+490
+00:38:36,100 --> 00:38:39,080
+من اليوترين والسرفيكس والبنيس
+
+491
+00:38:47,520 --> 00:38:51,360
+و اتشرحنا احنا يمكن الجملة الأخيرة اشرحناها ان ال
+
+492
+00:38:51,360 --> 00:38:55,860
+E6 و E7 هم المسؤولين عن ال suppression ل ال tumor
+
+493
+00:38:55,860 --> 00:39:00,880
+suppression genes اللي هم ال B53 و Retinoblastoma
+
+494
+00:39:00,880 --> 00:39:06,660
+factors طبعا هذا شكل من أشكال ال skin warts وهذا
+
+495
+00:39:06,660 --> 00:39:11,100
+شكل من أشكال ال genital warts اللي شايفينه طبعا
+
+496
+00:39:11,100 --> 00:39:14,200
+هنا ال growth بيكون
+
+497
+00:39:17,740 --> 00:39:21,760
+قد يكون بمستويات مختلفة، مش مستوى واحد، قد يكون
+
+498
+00:39:21,760 --> 00:39:25,720
+أكبر من ذلك، وقد يكون أصغر من ذلك، وبيصل لمراحل
+
+499
+00:39:25,720 --> 00:39:31,520
+معينة، وقد يشفى تلقائيا، أو قد يعالج من خلال
+
+500
+00:39:31,520 --> 00:39:35,920
+الحرق، إزالة بالحرق، أو بإزالة بالـ Liquid
+
+501
+00:39:35,920 --> 00:39:41,670
+Nitrogen، لكن المؤكد أن هذا الشكلالبسيط من ال
+
+502
+00:39:41,670 --> 00:39:46,790
+words شكل مميز و ال diagnosis غالبا بيكون clinical
+
+503
+00:39:46,790 --> 00:39:50,310
+يعني مش محتاجين laboratory diagnosis عشان نتعرف
+
+504
+00:39:50,310 --> 00:39:53,950
+على مين على اللي هو ال virus المرة الجاية ان شاء
+
+505
+00:39:53,950 --> 00:39:54,890
+الله بنكمل
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2651e9c97c4ff16bc74bd8b475a14fc71be6d8eb
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_postprocess.srt
@@ -0,0 +1,1912 @@
+1
+00:00:20,790 --> 00:00:23,830
+طيب بسم الله الرحمن الرحيم نكمل ما بدأنا المحاضرة
+
+2
+00:00:23,830 --> 00:00:27,950
+السابقة والمتعلقة بالـRNA Envelope Viruses وبدأنا
+
+3
+00:00:27,950 --> 00:00:31,570
+بالحديث عن أول فيروس بينتمي إلى الـOrthomax
+
+4
+00:00:31,570 --> 00:00:36,230
+Viruses اللي هو الـ Influenza Virus ويمكن آخر شيء
+
+5
+00:00:36,230 --> 00:00:41,880
+تحدثنا فيه اللي هو متعلق بإنه فيه تلت أنواعأو تلت
+
+6
+00:00:41,880 --> 00:00:45,200
+groups اللي هم group A و group B و group C هذا
+
+7
+00:00:45,200 --> 00:00:48,520
+يعني انه كل واحدة منهم تمتلك group antigen لكن كنا
+
+8
+00:00:48,520 --> 00:00:52,060
+فيه كمان type specific antigens و المتبادلة مثلا
+
+9
+00:00:52,060 --> 00:00:58,640
+في ال H و ال N و كنا مثلا ال ال ال الجروب A فيها
+
+10
+00:00:58,640 --> 00:01:04,460
+16 H من 1 إلى 16 ونفس الجروب فيها من 1 إلى 9 من
+
+11
+00:01:04,460 --> 00:01:08,720
+اللي هم ال N وبعدين اتحدث عن بعض التراكيب المتعلقة
+
+12
+00:01:08,720 --> 00:01:12,440
+بال matrix protein 1 و matrix protein 2 M1 و M2
+
+13
+00:01:12,440 --> 00:01:17,480
+وجودنا الأولاني هو structural بنائي بيعمل support
+
+14
+00:01:17,480 --> 00:01:22,800
+للمنبرين مع الكبسيد والثاني ب forms ion channel
+
+15
+00:01:22,800 --> 00:01:26,310
+وال ion channel جودنا مهمة جدا في عملية اللي هوالـ
+
+16
+00:01:26,310 --> 00:01:30,370
+Uncoating للفيروس لما يدخل داخل الخلية لكن هناك
+
+17
+00:01:30,370 --> 00:01:33,830
+أيضًا بروتين بنسميه non-structural لما نقول non
+
+18
+00:01:33,830 --> 00:01:36,710
+-structural لغاية ما نقصد فيها ان هو functional
+
+19
+00:01:36,710 --> 00:01:41,890
+يعني له function رئيسي اللي هو اللي سمينا NS1 ال
+
+20
+00:01:41,890 --> 00:01:47,870
+NS1 له طريقة رهيبة جدًا في ال virulence كيف
+
+21
+00:01:47,870 --> 00:01:52,790
+بيشتغل؟ بتعرفوا أن ال interferon هو أحد ال innate
+
+22
+00:01:52,790 --> 00:01:58,020
+immunity against virusesضد الفيروسات الـ
+
+23
+00:01:58,020 --> 00:02:00,720
+interferon بنبّي الخلايا الأخرى و بيخلّيها more
+
+24
+00:02:00,720 --> 00:02:04,160
+alert more immune to viral infection مين اللي
+
+25
+00:02:04,160 --> 00:02:07,380
+بيفرز ال interferon؟ نفس الخلايا المصادرة بالفيروس
+
+26
+00:02:07,380 --> 00:02:11,800
+عشان يصير فينا production ل interferon لازم يصير
+
+27
+00:02:11,800 --> 00:02:16,220
+فينا transcription ل mRNA عشان يصير translation لل
+
+28
+00:02:16,220 --> 00:02:20,400
+interferon اللي هو ال protein حضرة ال NS1 اللي هو
+
+29
+00:02:20,400 --> 00:02:23,540
+ال non structural protein one بيعمل عملية
+
+30
+00:02:23,540 --> 00:02:27,600
+inhibition لمين؟لـ Production of mRNA تبع الـ
+
+31
+00:02:27,600 --> 00:02:30,860
+Interferon يعني بيبنع تكوين الـ Interferon من
+
+32
+00:02:30,860 --> 00:02:35,600
+المادة وسط الصورة إذا هذه الـ Viability تبع اللي
+
+33
+00:02:35,600 --> 00:02:43,720
+هو الـ NS1 الآن ننتقل إلى فكرة أنه فيروس بيصيب
+
+34
+00:02:43,720 --> 00:02:48,760
+مخلوقات مختلفة مثلا لما بنقول waterfall أو water
+
+35
+00:02:48,760 --> 00:02:52,760
+birds إيش يعني water birds الطيور المائية الطيور
+
+36
+00:02:52,760 --> 00:02:53,700
+المائية إيش بتعرفوا عنها
+
+37
+00:02:58,130 --> 00:03:02,690
+الحقيقة انه هناك مئات ال species من هذا البط اللي
+
+38
+00:03:02,690 --> 00:03:05,630
+بنتكلم عنه أو اللي بيسميه water birds او water
+
+39
+00:03:05,630 --> 00:03:10,270
+fowl، بنتكلم عن horses، بنتكلم عن swans، خنازير،
+
+40
+00:03:10,270 --> 00:03:14,770
+هذه كلها species اللي لها specific strains اللي
+
+41
+00:03:14,770 --> 00:03:20,470
+بتصيبش الإنسانما بتصيبش الانسان وبالتالي ربما ..
+
+42
+00:03:20,470 --> 00:03:24,930
+ربما يصيب الحصان وما يصيب الخنزير والانسان ..
+
+43
+00:03:24,930 --> 00:03:27,390
+الفيروس يصيب الانسان وما يصيب الخنزير يعني في عقل
+
+44
+00:03:27,390 --> 00:03:31,270
+مشترك وقلنا لكوا ان ممكن للانسان او فيروسات
+
+45
+00:03:31,270 --> 00:03:37,110
+الانسان تكتسب H جديدة او N جديدة من وين؟ من مصادر
+
+46
+00:03:37,110 --> 00:03:40,370
+اخرى حيوانية هذا الكلام ماتصيرش الا في group A
+
+47
+00:03:40,370 --> 00:03:43,910
+group B مابصيرش فيها الكلام هذا ليش؟ لأنها تصيب
+
+48
+00:03:43,910 --> 00:03:49,660
+الا الانسانوصل الصورة لما يكون في مصادر أخرى لل H
+
+49
+00:03:49,660 --> 00:03:54,780
+وال N من حيوانات أو طيور مائية قد تنتقل إلى
+
+50
+00:03:54,780 --> 00:03:57,800
+الإنسان عبر التقن اللي كنا نقول عنها reassortment
+
+51
+00:03:57,800 --> 00:04:01,080
+إنه اتنين فيروس يعمل infection ل one single cell
+
+52
+00:04:01,080 --> 00:04:05,060
+ويصير في exchange لل DNA segment أو fragment
+
+53
+00:04:10,830 --> 00:04:14,930
+ده كان من 16 type من الـ HA و جداش من الـ NA اللي
+
+54
+00:04:14,930 --> 00:04:21,410
+هم 9 types في البنادمين في البشر غالبا H1 و H2 و
+
+55
+00:04:21,410 --> 00:04:25,610
+H3 هم المسيطرين هم ال dominant يعني ال predominant
+
+56
+00:04:25,610 --> 00:04:29,230
+و ال N1 و N2 من ال neuroimmunization يبقى فيه
+
+57
+00:04:29,230 --> 00:04:33,900
+تلاتة H و فيه اتنين Nفمثلا عندنا ال influenza
+
+58
+00:04:33,900 --> 00:04:37,840
+virus type B only human virus عشان انا قلنالكوا
+
+59
+00:04:37,840 --> 00:04:41,460
+مافيش امكانية الاكتساب H جديدة او N جديدة من
+
+60
+00:04:41,460 --> 00:04:46,060
+المخلوقات اخرى يبقى بيه مايصيرلوش antigenic shift
+
+61
+00:04:46,060 --> 00:04:50,860
+ايش بيصيرله؟ antigenic drift ايش drift؟هو تغيير
+
+62
+00:04:50,860 --> 00:04:57,140
+طفيف في الـ Antigen Structure، وأنا أؤكد مرة أخرى
+
+63
+00:04:57,140 --> 00:05:01,460
+هنا بأن تأثير الـ Antigenic Drift أو الـ Shift ما
+
+64
+00:05:01,460 --> 00:05:06,360
+بنقدرش نحكم عليهم من أكتر خطورة، لكن التغيير
+
+65
+00:05:06,360 --> 00:05:10,940
+الدراماتيكي معروف وموجود في الـ Shift، تغيير طفيف
+
+66
+00:05:10,940 --> 00:05:12,880
+في اللي هو الـ Antigenic Drift
+
+67
+00:05:16,940 --> 00:05:20,600
+فاكرين في الجدول اللي شوفنا فيه السنوات تبع
+
+68
+00:05:20,600 --> 00:05:24,060
+الأوبئة؟ شوفنا ال prototype virus وشوفنا كيف ال
+
+69
+00:05:24,060 --> 00:05:28,140
+nominclature اللي هي تسمية للفيروسات فمثلا هنا A
+
+70
+00:05:28,140 --> 00:05:32,140
+تعني فيروس A Philippines يعني انتشر فيه الفلبين
+
+71
+00:05:32,140 --> 00:05:36,260
+سنة الف وتسعمائة واتنين وتمانين والسلالة المسببة
+
+72
+00:05:36,260 --> 00:05:42,200
+واطلعة على الرقم لل H و ال N في هذه السلالة H3 N2
+
+73
+00:05:42,200 --> 00:05:50,310
+هل خرجنا من المعروف؟ H1H2 H3 N1 N2 هاي اللي هم
+
+74
+00:05:50,310 --> 00:05:56,670
+الخمسة هذا لا يعني انه فيش غيرهم احنا شوفنا H5 N1
+
+75
+00:05:56,670 --> 00:06:02,650
+وحنشوف كمان شوية كمان H7 لكن هذه السلالات أصلا من
+
+76
+00:06:02,650 --> 00:06:06,490
+أين جاية من الطيور جاية من الطيور مش من ال human
+
+77
+00:06:08,630 --> 00:06:10,670
+طبعا التفسير اللي قوله كل الكلام اللي قولته هنا
+
+78
+00:06:10,670 --> 00:06:15,570
+تفسير ليه اللي هو تسمية جنة A هو type A اتطلعوا
+
+79
+00:06:15,570 --> 00:06:23,710
+يعرفوا عدد الوفيات هم 226 ضعيف بنسبة وفيات 63%
+
+80
+00:06:23,710 --> 00:06:28,790
+يعني من أعلى نسب القتل لكل الفيروسات والبكتيريا
+
+81
+00:06:28,790 --> 00:06:35,140
+اللي بنعرفها في الوقت الحالي 63% حالات وفياتالان
+
+82
+00:06:35,140 --> 00:06:40,020
+الخطورة كمان مرة ان هذه السلالة highly pathogenic
+
+83
+00:06:40,020 --> 00:06:46,200
+الفيرالينس بتاعها عالي جدا لكن الشئ المطمئن انها
+
+84
+00:06:46,200 --> 00:06:49,020
+مابتنتقلش من انسان الى انسان
+
+85
+00:06:51,630 --> 00:06:57,050
+اللي بيصاب فيها غالبا بيصاب بعد intense exposure
+
+86
+00:06:57,050 --> 00:07:02,750
+يعني تعرض كثيف للفيروس احتكاك مباشر مع الدواجن
+
+87
+00:07:02,750 --> 00:07:06,730
+المصابة وقد يكون الاحتكاك لفترات طويلة وحنحاول
+
+88
+00:07:06,730 --> 00:07:11,710
+نفسر ليش بتصيب الدواجن وبتصيبش الإنسان وإن أصابت
+
+89
+00:07:11,710 --> 00:07:15,630
+الإنسان فقط بتصيروا بعد انها intense exposure زي
+
+90
+00:07:15,630 --> 00:07:22,370
+ما ذكرناأخر جملة في اللوحة بتقول ان الـ Spread of
+
+91
+00:07:22,370 --> 00:07:25,650
+H5 in one strain from person to person occurs
+
+92
+00:07:25,650 --> 00:07:30,650
+rarely، نادرا ما حصل، والحقيقة أن حتى الدراسة اللي
+
+93
+00:07:30,650 --> 00:07:34,470
+ذكرت أنه في انتقال من إنسان إلى إنسان، هذه الدراسة
+
+94
+00:07:34,470 --> 00:07:37,750
+was not supported، لم تدعم من أي دراسة أخرى،
+
+95
+00:07:37,750 --> 00:07:42,330
+وبالتالي لحد الآن الخط اللي بنعرفه أنه بتنتقل من
+
+96
+00:07:42,330 --> 00:07:45,950
+الدواجن إلى الإنسان وليس من إنسان إلى إنسان
+
+97
+00:07:49,430 --> 00:07:56,090
+في 2005 الـ H5N1 انتشر من آسيا ورقع سيبيريا وعلى
+
+98
+00:07:56,090 --> 00:08:02,390
+أوروبا الشرقية هناك الفيروس قتل thousands of birds
+
+99
+00:08:02,390 --> 00:08:09,390
+لكن لم يصب البنادمين بأي حالة avian flu في 2008 لم
+
+100
+00:08:09,390 --> 00:08:11,110
+تسجل أي حالة
+
+101
+00:08:15,900 --> 00:08:19,320
+حالة بشرية للـ avian flu في الولايات المتحدة لكن
+
+102
+00:08:19,320 --> 00:08:26,580
+في ال 2005 اه عفوا في نفس السنة كان هناك حالتين
+
+103
+00:08:26,580 --> 00:08:33,720
+بشريات من ال influenza سببهم strain جديد اسمه H7N2
+
+104
+00:08:33,720 --> 00:08:37,980
+والـ H7N2 هو ايضا avian influenza
+
+105
+00:08:47,400 --> 00:08:53,660
+الحاجز اللى كان بيننا وبين الطيور يزول يزول هذا
+
+106
+00:08:53,660 --> 00:08:58,420
+الحاجز طبعا البعض بيقول ان احنا في ضل التقدم
+
+107
+00:08:58,420 --> 00:09:03,080
+التكنولوجي والمدن وابتعدنا عن الزراع ان احنا
+
+108
+00:09:03,080 --> 00:09:09,180
+بعيدين عن الحيواناتاحنا بنحتكب الحيوانات شئنا ام
+
+109
+00:09:09,180 --> 00:09:13,840
+قبينا تمام من خلال الغذاء من خلال الغذاء الحيوانات
+
+110
+00:09:13,840 --> 00:09:19,720
+تشكل جزء كبير من غذانا فى حد ما بيستحقش دواجن طب
+
+111
+00:09:19,720 --> 00:09:23,000
+الدواجن هي اللى هي اللى ممكن ايه تنقلنا ال avian
+
+112
+00:09:23,000 --> 00:09:31,590
+fluاحتكاكنا بالحياة لم يقل ربما صار اقل ظهورا اقل
+
+113
+00:09:31,590 --> 00:09:35,670
+شيوعا لكن ما زال منتشر بشكل كبير باشكال اخرى من
+
+114
+00:09:35,670 --> 00:09:42,170
+خلال الغذاء في شيء لطيف في ال 2005 حصل نبشوا على
+
+115
+00:09:42,170 --> 00:09:46,890
+جثة من اللي توفوا في ال 1918 اللي هو متوان الحمة
+
+116
+00:09:46,890 --> 00:09:51,710
+او الانفلوانزا الإسبانية في منطقة من المناطق اللي
+
+117
+00:09:51,710 --> 00:09:57,260
+هي دائما فيها جليدفأخذوا الجثة وحللوا الفيروس اللي
+
+118
+00:09:57,260 --> 00:10:03,900
+موجود في الرئتين تبع الإنسان المتوفق من الحمّة
+
+119
+00:10:03,900 --> 00:10:10,040
+الإسبانية لجوا إن السلالة تبعته تشبه إلى حد كبير
+
+120
+00:10:10,040 --> 00:10:12,220
+H5N1
+
+121
+00:10:13,540 --> 00:10:17,540
+يعني الفرق اللي بين اللي بين الحُمّة هذه و الحُمّة
+
+122
+00:10:17,540 --> 00:10:21,020
+هذه ان هذه الكلمة تنتقل من إنسان لإنسان وهذه لا
+
+123
+00:10:21,020 --> 00:10:25,960
+تنتقل إلا من الدواجن إلى الإنسان فلو صار فيه تغيير
+
+124
+00:10:25,960 --> 00:10:31,160
+يمكن هذا الفيروس من تخطي هذا الحجز يبقى معناه
+
+125
+00:10:31,160 --> 00:10:35,020
+الحكي إمكانية انتشاره في العالم و قتله لأعداد
+
+126
+00:10:35,020 --> 00:10:40,000
+كبيرة هتكون إمكانية مرتفعة جدا وهذه المرة هتكون
+
+127
+00:10:40,000 --> 00:10:44,950
+أصعب ليش؟في 1918 ماكانش فيه سهولة التنقل اللي
+
+128
+00:10:44,950 --> 00:10:49,310
+اليوم موجودة في هذا العالم وبالتالي الاعتقاد ان
+
+129
+00:10:49,310 --> 00:10:53,630
+يكون فيه انتشار واسع يعني بيكون اكبر من ذي قبل
+
+130
+00:10:53,630 --> 00:10:59,350
+الان نفسر لماذا ال H5N1 بصيب الدواجن وما بصيبش
+
+131
+00:10:59,350 --> 00:11:04,170
+البرادمين لجوا ان ال receptors لهذا الفيروس موجودة
+
+132
+00:11:04,170 --> 00:11:08,960
+في كل ال respiratory tract بعتمين تحت الدواجنلكن
+
+133
+00:11:08,960 --> 00:11:13,860
+احنا كبشر نمتلك ال receptors وين؟ نمتلكها فقط في
+
+134
+00:11:13,860 --> 00:11:17,540
+ال alveoli فعشان ال virus يعمل infection لازم نسأل
+
+135
+00:11:17,540 --> 00:11:19,740
+وين؟ ال alveoli وانتوا عارفين ان احنا عندنا
+
+136
+00:11:19,740 --> 00:11:24,220
+ميكانيزم تطرد دايما ايه؟ الفيروسات الا اذا كان
+
+137
+00:11:24,220 --> 00:11:28,980
+كمان مرة التعرض intense اشيان intense كثيف يعني
+
+138
+00:11:28,980 --> 00:11:35,040
+وصل ال alveoli من كثرة مكان موجود الفيروس في
+
+139
+00:11:35,040 --> 00:11:37,320
+الهواء او في ال environment
+
+140
+00:11:41,950 --> 00:11:47,390
+طيب ليش هذا ال strain بالذات more violent و نسبة
+
+141
+00:11:47,390 --> 00:11:50,690
+القتل عنده عالية جدا؟ بقولنا فيه سببين احنا
+
+142
+00:11:50,690 --> 00:11:55,090
+عرفناهم، سببين عرفناهم، واحد it's relative
+
+143
+00:11:55,090 --> 00:11:57,850
+resistance to interferon، عشان اقولنا بيجيب شوي ال
+
+144
+00:11:57,850 --> 00:12:02,670
+influenza بتمنع تكون ال interferon، هذا لو ال
+
+145
+00:12:02,670 --> 00:12:09,460
+interferon متكون أصلا resistant لهرقم اتنين
+
+146
+00:12:09,460 --> 00:12:14,420
+بيستثير جهاز المناعة من خلال الـ cytokine
+
+147
+00:12:14,420 --> 00:12:18,420
+production بيعمل induction للـ cytokines وانا يمكن
+
+148
+00:12:18,420 --> 00:12:23,060
+في هذا ال course بالذات اكثر من عشر مرات اكدت على
+
+149
+00:12:23,060 --> 00:12:30,310
+ان معظمالأعراض والضرر الناتج عن الأمراض الفيروسية
+
+150
+00:12:30,310 --> 00:12:33,350
+بيكون ناتج عن مش الفيروس نفسه وانما عن جهاز
+
+151
+00:12:33,350 --> 00:12:37,410
+المناعة attacking the virally infected cells فلما
+
+152
+00:12:37,410 --> 00:12:41,010
+بيصير فيه cytokines جهاز المناعة بييجي وبيعمل ال
+
+153
+00:12:41,010 --> 00:12:44,450
+damage له ممكن يعمل حاجة اسمها acute respiratory
+
+154
+00:12:44,450 --> 00:12:48,610
+distress syndrome وهذا يعني سيء للغاية وممكن يؤدي
+
+155
+00:12:48,610 --> 00:12:52,130
+الى الوفاة في مرضى ال H5N1
+
+156
+00:13:06,220 --> 00:13:11,080
+هنا نجيب نتكلم عن العقاقيل المستخدمة في العلاج
+
+157
+00:13:11,080 --> 00:13:15,500
+هناك نوعية من العقارات أو العقاقيل عفوا عقارات
+
+158
+00:13:15,500 --> 00:13:20,590
+بتصير real estateالعقاقير فيهم دي حاجة اسمها
+
+159
+00:13:20,590 --> 00:13:24,230
+neuroaminidase inhibitors اللي هي الموانع او
+
+160
+00:13:24,230 --> 00:13:27,390
+مثبتات ال neuroaminidase وكلكوا بتعرفوا ان ال
+
+161
+00:13:27,390 --> 00:13:33,210
+neuroaminidase له وظيفة نهائية في قص الفيروس عن
+
+162
+00:13:33,210 --> 00:13:37,870
+الخلية المصابة فصلها عن الخلية المصابةالان الـ
+
+163
+00:13:37,870 --> 00:13:40,370
+Neuraminidase Inhibitor بعد الحاجة الـ
+
+164
+00:13:40,370 --> 00:13:43,910
+Neuraminidase مش هيشتغل مش هيقص اللي هو ال .. ال
+
+165
+00:13:43,910 --> 00:13:48,490
+virus فهيدله منتصق بمين؟ بالخلية المصابة يبقى لان
+
+166
+00:13:48,490 --> 00:13:53,510
+ينتقل الى خلايا أخرى وهذا بيقلل من المرض و طبعا
+
+167
+00:13:53,510 --> 00:13:58,170
+بتدريج بروح ال disease في اسمين مشهورين جدا و
+
+168
+00:13:58,170 --> 00:14:04,300
+سورتاميفير والتاني زنامفيرالاسم التجارة الأول
+
+169
+00:14:04,300 --> 00:14:08,580
+Tamiflu وهذا الاسم هو الأشهر على وجه الأرض كان في
+
+170
+00:14:08,580 --> 00:14:13,020
+الفين و خمسة و الفين و ستة لما كان المرض بيلفلف في
+
+171
+00:14:13,020 --> 00:14:16,720
+الدنيا و الناس خايفة منه فكان شركات الأدوية أو
+
+172
+00:14:16,720 --> 00:14:21,900
+شركة الأدوية المصنعة باعت كميات ضخمة منه كل الدول
+
+173
+00:14:21,900 --> 00:14:27,560
+اشترت تخزن تحصب لوجود حالات يعني من هذا ال disease
+
+174
+00:14:29,750 --> 00:14:33,070
+يبقى الـ H5N1 sensitive للعقارين اللي هم مشكلة
+
+175
+00:14:33,070 --> 00:14:39,290
+مارسهمهمOseltamivir وXanamivir بينما resistant to
+
+176
+00:14:39,290 --> 00:14:41,950
+the drugs that inhibit entry انتوا عارفين ان ال
+
+177
+00:14:41,950 --> 00:14:48,650
+entry للفيروس برضه عملية مهمة الان ال H5N1 دون عن
+
+178
+00:14:48,650 --> 00:14:54,490
+ال others مقاوم لل drugs اللى بتستخدم لمنا دخول
+
+179
+00:14:54,490 --> 00:14:57,490
+الفيروس اللى هم ال Amantadine وRamantadine اذا
+
+180
+00:14:57,490 --> 00:15:01,370
+Ramantadine وAmantadine هى resistant لهمطبعا
+
+181
+00:15:01,370 --> 00:15:04,490
+التامي فلو هو drug of choice للعلاج و لل
+
+182
+00:15:04,490 --> 00:15:07,150
+prevention يعني بمعنى اخر لو واحد صار عنده
+
+183
+00:15:07,150 --> 00:15:10,890
+exposure و بنعمله prophylaxis بنعطيه برضه تمي فلو
+
+184
+00:15:10,890 --> 00:15:13,950
+بالنسبة
+
+185
+00:15:13,950 --> 00:15:16,790
+لل vaccination مافيش vaccine .. مافيش vaccine
+
+186
+00:15:16,790 --> 00:15:20,750
+human vaccine لكن في animal vaccine بمعنى انه
+
+187
+00:15:20,750 --> 00:15:24,630
+بنعطيه دواجن H5N1 vaccine
+
+188
+00:15:29,780 --> 00:15:32,860
+كثير من الكلام المذكور هنا مقرر لكن لا بقص انه
+
+189
+00:15:32,860 --> 00:15:36,940
+انكرر بعض المعلومات لاجل ترسيخها في الأذهان ان شاء
+
+190
+00:15:36,940 --> 00:15:40,820
+الله الانتقال عبر ال respiratory droplets
+
+191
+00:15:43,060 --> 00:15:46,500
+ال epidemics او ال pandemics بتحدث متى يا جماعة؟
+
+192
+00:15:46,500 --> 00:15:51,920
+بتحدث عندما يكون السكان في منطقة معينة ليس لديهم
+
+193
+00:15:51,920 --> 00:15:57,580
+مناعة او اي نوع من المناعة ضد السلالة التي ستسبب
+
+194
+00:15:57,580 --> 00:16:03,760
+هذا الوباء كمان مرة انديفيروس أصاب مجموعة من البشر
+
+195
+00:16:03,760 --> 00:16:07,840
+وشوفوا منه هل الفيروس هذا بيقدر يعمل epidemic مرة
+
+196
+00:16:07,840 --> 00:16:10,840
+تانية فيهم؟بقدرش أعمل epidemic مرة تانية فيها،
+
+197
+00:16:10,840 --> 00:16:15,960
+ليش؟ لأنهم كوّنوها مناعة أنا بجيب مثال دايما واضح
+
+198
+00:16:15,960 --> 00:16:22,400
+ال smallpox قضية عليه سنة 1977 يعني كلنا احنا لم
+
+199
+00:16:22,400 --> 00:16:27,980
+نصب قبل ذلك ولم نطعم ضد هذا الفيروس لو اليوم
+
+200
+00:16:27,980 --> 00:16:32,720
+الفيروس رجع مرة تانية احنا مؤهلين ان يصير لنا وباء
+
+201
+00:16:32,720 --> 00:16:36,850
+ولا مش مؤهلين؟عارفين ليش مؤهلين؟ لأن ولا واحد فينا
+
+202
+00:16:36,850 --> 00:16:40,750
+بيمتلك منع تذكر ال herd immunity او ال community
+
+203
+00:16:40,750 --> 00:16:44,890
+immunity ان الناس المطعمين بيقللوا فرص الناس الغير
+
+204
+00:16:44,890 --> 00:16:48,330
+مطعمين في الإصابة لكن احنا مافيش حد مطعم أساسا
+
+205
+00:16:48,330 --> 00:16:52,510
+وبالتالي فرصة ان يحدث وباء ان يحدث وباء بتكون
+
+206
+00:16:52,510 --> 00:16:58,200
+عالية جدا، إذا متى؟يمكن للانفلونزا ان تحدث هبط
+
+207
+00:16:58,200 --> 00:17:03,640
+عندما يكون التغيير في الانتيجينات تراها كافي ان
+
+208
+00:17:03,640 --> 00:17:08,060
+ولا واحد في المنطقة عنده antibody لهذا الانتيجين،
+
+209
+00:17:08,060 --> 00:17:12,340
+يعني صار تغيير اما drift او shift لهذا الانتيجين
+
+210
+00:17:20,440 --> 00:17:23,720
+الجملة التانية في الفقرة بتقول ان influenza occurs
+
+211
+00:17:23,720 --> 00:17:27,460
+primarily in the winter months اللي دي الأشهر اللي
+
+212
+00:17:27,460 --> 00:17:34,580
+طبعا بدأنا احضروا أنفسكم ليها ال influenza when it
+
+213
+00:17:34,580 --> 00:17:37,620
+and bacterial pneumonia secondary to influenza
+
+214
+00:17:37,620 --> 00:17:40,500
+causes significant number of deaths especially in
+
+215
+00:17:40,500 --> 00:17:44,220
+older people في ممكن في حد المحاضرة اتكلمنا عن
+
+216
+00:17:44,220 --> 00:17:47,920
+five percent mortality rate صح؟ وبنالكوا في مين
+
+217
+00:17:47,920 --> 00:17:52,520
+هذه؟ في ال old ageما هي السبب في الـ old age؟ شكله
+
+218
+00:17:52,520 --> 00:17:57,080
+تاني إن هما منعتهم بالفعل منخفضة واحتمالية الـ
+
+219
+00:17:57,080 --> 00:17:59,840
+complication إنه مش بس تكون upper respiratory
+
+220
+00:17:59,840 --> 00:18:04,860
+tract تنزل وتعمل نيومونيا عالية والاحتمالية الأخرى
+
+221
+00:18:04,860 --> 00:18:09,360
+إن يصاب الإنسان ب secondary bacterial pneumonia زي
+
+222
+00:18:09,360 --> 00:18:12,420
+Staphylococcus aureus
+
+223
+00:18:14,340 --> 00:18:17,480
+احتمالية الوفيات بتكون عالية في هؤلاء الناس، مين
+
+224
+00:18:17,480 --> 00:18:23,000
+كمان فئات، خدنا نقول أكتر عرضة للإصابة بتكون فيهم
+
+225
+00:18:23,000 --> 00:18:26,180
+severe، اللي هم ال infants الأقل من سنتين، الأقل
+
+226
+00:18:26,180 --> 00:18:31,740
+من سنتين ال
+
+227
+00:18:31,740 --> 00:18:37,360
+immunity اللي بتحدث متكونة من تلت عناصر رئيسية،
+
+228
+00:18:37,360 --> 00:18:42,680
+IGAوال IGA is protective ليش protective؟ لأن هو
+
+229
+00:18:42,680 --> 00:18:45,780
+اللي بيحمي الميوكاس membrane والفيروس أصلا بيدخل
+
+230
+00:18:45,780 --> 00:18:50,480
+عبر الميوكاس membrane وبالتالي وجود IGA غالبا
+
+231
+00:18:50,480 --> 00:18:57,300
+بيكون protective لكن أيضا الجسم بينتج IGG وهو
+
+232
+00:18:57,300 --> 00:19:01,120
+يساعد لكن less protective يعني لو افترضنا أن ال
+
+233
+00:19:01,120 --> 00:19:05,620
+IGA مش موجود وال IGG موجود مابيحميناش من مين من
+
+234
+00:19:05,620 --> 00:19:10,050
+الانفلوانزلكن الدور الأعظم كما تعلمون لـ cytotoxic
+
+235
+00:19:10,050 --> 00:19:17,310
+T cell في نقطة أهم جدا اللي بتميز ال influenza عن
+
+236
+00:19:17,310 --> 00:19:21,110
+الرشح
+
+237
+00:19:22,530 --> 00:19:27,630
+إنه فيه ألم في العضلات و ألم العضلات ناتج عن
+
+238
+00:19:27,630 --> 00:19:31,050
+فاكرين جاب شويه جون انه في induction ل cytokines
+
+239
+00:19:31,050 --> 00:19:35,070
+ال cytokines و هي بتلفلف في الدم بتعمل induction
+
+240
+00:19:35,070 --> 00:19:45,730
+للألم اللي احنا بسميه ماليجي أو ألم في العضلات ال
+
+241
+00:19:45,730 --> 00:19:49,780
+incubation period ل disease is very shortقصيرة جدا
+
+242
+00:19:49,780 --> 00:19:54,420
+من 24 ساعة ل 48 ساعة ويمكن البعض منكم ملاحظ هذه
+
+243
+00:19:54,420 --> 00:19:59,720
+الملاحظة انه مابين فترة شعوره بأنه بده يمرض لحين
+
+244
+00:19:59,720 --> 00:20:04,020
+ظهور الأعراض في ال influenza غالبا بتكون قد ساعات
+
+245
+00:20:04,020 --> 00:20:08,200
+يعني مثلا الظهر روح تعبان نامله ساعة زمن بصحى كل
+
+246
+00:20:08,200 --> 00:20:13,340
+الأعراض موجودة من حرارة من رشح اللي هو ال ال ال
+
+247
+00:20:13,340 --> 00:20:17,300
+sneezing من ألم في المفاصل ألم في العضلات كلها
+
+248
+00:20:17,300 --> 00:20:22,910
+ممكن تكونموجودة بشكل سريع لذلك they can develop a
+
+249
+00:20:22,910 --> 00:20:31,070
+suddenly يعني بشكل فجأة حسب ما على بعضكم في دياريا
+
+250
+00:20:31,070 --> 00:20:36,020
+و vomiting في ال influenza؟فيه بس in rare cases ..
+
+251
+00:20:36,020 --> 00:20:39,400
+in rare cases بتكون associated with بالفعل اللي هو
+
+252
+00:20:39,400 --> 00:20:43,660
+influenza من أسوأ ال complications زي ما ذكرنالكم
+
+253
+00:20:43,660 --> 00:20:47,640
+اللي هو ال .. ال Staphylococcal aureus .. aureus
+
+254
+00:20:47,640 --> 00:20:51,860
+ال pneumonia غالبا بتصاحب الحالات ال influenza
+
+255
+00:20:51,860 --> 00:20:56,040
+طبعا ال recovery بيكون من أربع إلى سبع أيام في ال
+
+256
+00:20:56,040 --> 00:21:00,310
+normal peopleالناس العاديين بيشوفوا بدون أي حاجة
+
+257
+00:21:00,310 --> 00:21:06,530
+من أربع إلى سبعية لكن وجود influenza أو bacterial
+
+258
+00:21:06,530 --> 00:21:11,710
+pneumonia بيعقد مسار المرض و قد يوطيله لعدة أسابيع
+
+259
+00:21:11,710 --> 00:21:17,710
+و قد يؤدي كما ذكرنا إلى الوفاة هذه الفقرة تم
+
+260
+00:21:17,710 --> 00:21:22,550
+دراستها سابقا في فيروس اسمه chickenpox صح؟ raise
+
+261
+00:21:22,550 --> 00:21:29,090
+syndrome هذكركم بالاسبارين؟عدم تناول الاسبرين في
+
+262
+00:21:29,090 --> 00:21:34,130
+حالتان إذا كان ال influenza من نوع B أو في حالة ال
+
+263
+00:21:34,130 --> 00:21:38,110
+Varicella Zoster بيصير فيانا two conditions أو two
+
+264
+00:21:38,110 --> 00:21:41,950
+symptoms سevere encephalopathy و liver
+
+265
+00:21:41,950 --> 00:21:47,640
+degeneration هو rare disease لكنهvery خلّينا نقول
+
+266
+00:21:47,640 --> 00:21:51,920
+live threatening يهدد حياة الناس خاصة في الأطفال
+
+267
+00:21:51,920 --> 00:21:54,900
+اللي يصابوا بال viral infection اللي يكون عنها
+
+268
+00:21:54,900 --> 00:21:59,460
+influenza B و chickenpox طبعا ال mechanism by
+
+269
+00:21:59,460 --> 00:22:03,100
+which aspirin produces this disease is not
+
+270
+00:22:03,100 --> 00:22:08,560
+understood لكن هي ملاحظة لذلك ال aspirin لا يُعطى
+
+271
+00:22:08,560 --> 00:22:11,780
+في حالة ال influenza ولا في حالة ال chickenpox
+
+272
+00:22:14,950 --> 00:22:17,970
+الـ lab diagnosis يا جماعة، في حدا فيكم بيعرفش شخص
+
+273
+00:22:17,970 --> 00:22:22,050
+الـ influenza؟ انتوافي حداتيكوا باعرفش شخص
+
+274
+00:22:22,050 --> 00:22:27,850
+الانفلوانزا؟ متهيألي الطباء بشخصه الانفلوانزا
+
+275
+00:22:27,850 --> 00:22:32,010
+clinically بمعنى ان هو مش محتاج هو فحوصات لكن و مع
+
+276
+00:22:32,010 --> 00:22:36,110
+ذلك بنقولكوا انه هناك العديد من الفحوصات المتوفرة
+
+277
+00:22:36,110 --> 00:22:39,570
+للانفلوانزا و بتتاخد للكشف عن الفيروس في ال
+
+278
+00:22:39,570 --> 00:22:42,770
+secretions اللي هو ال nasal secretion او ال throat
+
+279
+00:22:42,770 --> 00:22:47,700
+washing او ال sputumوبنستخدم فيها تقنيات مختلفة
+
+280
+00:22:47,700 --> 00:22:51,500
+مثل الـ direct fluorescent antibody ال polymerase
+
+281
+00:22:51,500 --> 00:22:55,500
+chain reaction in PCR أو ال cell culture based
+
+282
+00:22:55,500 --> 00:22:59,940
+test يعني فحصات متمدة على إنه نم ال فيروس على cell
+
+283
+00:22:59,940 --> 00:23:07,220
+cultureو في عنا rapid tests بتاعه ال pregnancy
+
+284
+00:23:07,220 --> 00:23:11,960
+test ال cartridge تمام او ال hepatitis test او ال
+
+285
+00:23:11,960 --> 00:23:15,840
+aids test اللي استربيت هذه تمام؟ هذه الفحوصات اللي
+
+286
+00:23:15,840 --> 00:23:22,140
+هان متوفرة وبشكل يعني common في ال ..القطاع
+
+287
+00:23:22,140 --> 00:23:25,760
+التشخيصي لكن لو جينا ندورنا على القطاع الغزة
+
+288
+00:23:25,760 --> 00:23:30,260
+بنلاقي أنه يخلوا من هذه الفحوصات السبب كمان مرة هو
+
+289
+00:23:30,260 --> 00:23:34,280
+الاعتماد التام في التشخيص على اللي هو ال clinical
+
+290
+00:23:34,280 --> 00:23:39,040
+impression و أصلا يعني في مجتمع زي مجتمعنا ال
+
+291
+00:23:39,040 --> 00:23:43,240
+inflammation اعتبر مرض يستدعي الذهاب إلى الطبيب في
+
+292
+00:23:43,240 --> 00:23:46,180
+معظم الأحيان شعب صامد
+
+293
+00:23:49,420 --> 00:23:53,980
+أيضا مستوى ال antibody يمكن قياسه لماه من الدم
+
+294
+00:23:53,980 --> 00:23:57,800
+وينطبق عليه نفس القوة اللى كنا نقوله زمان إن
+
+295
+00:23:57,800 --> 00:24:02,140
+ارتفاع في ال titer طبعا الفحوصات اللى بنستخدمها
+
+296
+00:24:02,140 --> 00:24:05,060
+لقياس ال antibody في ال titer اللى هم ال hem
+
+297
+00:24:05,060 --> 00:24:07,880
+agglutination inhibition أو ال complement fixation
+
+298
+00:24:07,880 --> 00:24:13,140
+test كلا هما يستخدم لتقدير الأجسام المضادة في دم
+
+299
+00:24:13,140 --> 00:24:18,860
+المرضىهذه بعض الأمثلة بتورينا إنه كيف بناخد
+
+300
+00:24:18,860 --> 00:24:23,020
+نازوفرينجيا للسواب نعمله mixing بنحدد وقت زمان
+
+301
+00:24:23,020 --> 00:24:27,420
+معين بعدين بنحط ال strip فيه وبعد ال strip فترة
+
+302
+00:24:27,420 --> 00:24:30,980
+زمانية معينة بنقرأ إذا تكون خطوط بصت فإذا ما تكون
+
+303
+00:24:30,980 --> 00:24:36,200
+خطوط ملونة بيكون الفحص negative هذا فحص تاني flu
+
+304
+00:24:36,200 --> 00:24:37,360
+oya
+
+305
+00:24:39,580 --> 00:24:45,800
+وهذا كمان اللي هو Z-stat flu وبيعتمد على استخدام
+
+306
+00:24:45,800 --> 00:24:48,660
+اللي هو ال neuroaminidase، ال neuroaminidase
+
+307
+00:24:48,660 --> 00:24:52,980
+بتعرفين بيكسر جنة اللي هو السيالك أسد فبيحطوا
+
+308
+00:24:52,980 --> 00:24:56,940
+substrate، substrate، هذا ال substrate مرتبط ممين؟
+
+309
+00:24:56,940 --> 00:25:02,830
+بسيالك أسد analogالان لو في فيروس في المكان وحاطين
+
+310
+00:25:02,830 --> 00:25:06,950
+عليه ال substrate هذا هيفصل مين؟ هيفصل السيالك أسد
+
+311
+00:25:06,950 --> 00:25:10,770
+لأن ال neuro aminic acid هو سيالك أسد، هو سيالك
+
+312
+00:25:10,770 --> 00:25:13,630
+أسد، هيفصل ال chromogene اللي هو ال substrate
+
+313
+00:25:13,630 --> 00:25:18,530
+الملون عن السيالك
+
+314
+00:25:18,530 --> 00:25:22,550
+أسد وبتالي بيطلع عندنا لون مميز، هذا فحص فكرته
+
+315
+00:25:22,550 --> 00:25:26,710
+حلوة ومستخدم أيضا في diagnosis معتمد على مين كم
+
+316
+00:25:26,710 --> 00:25:28,850
+مرة؟ على neuroaminidase
+
+317
+00:25:30,690 --> 00:25:35,550
+التريتمنت للفيرال الانفلوانزا تتلخص في مجموعة من
+
+318
+00:25:35,550 --> 00:25:41,170
+العقاقير مثل الريمانتدين type A only وطبعا شفنا
+
+319
+00:25:41,170 --> 00:25:44,650
+انه فاشل هذا الريمانتدين والأمانتدين كان فاشل في
+
+320
+00:25:44,650 --> 00:25:49,190
+مين؟ في ال H5N1 لكن في الاخرين الفيروس الانفلوانزا
+
+321
+00:25:49,190 --> 00:25:53,590
+شغل type A وtype A الامانتدين زي المفير ممكن
+
+322
+00:25:53,590 --> 00:25:58,420
+يستخدموا فيهافي الـ type A و الـ type B لكن لحظة
+
+323
+00:25:58,420 --> 00:26:04,880
+لم يعتمد كإجراء ويقائي الذنبير لا يستخدم كإجراء
+
+324
+00:26:04,880 --> 00:26:09,540
+ويقائي بينما الأسر الذنبير بيستخدموا لإلاج و
+
+325
+00:26:09,540 --> 00:26:13,800
+بيستخدموا كمرة لمين؟ لـ prevention و بيستخدم الـ
+
+326
+00:26:13,800 --> 00:26:14,940
+type A و الـ type B
+
+327
+00:26:18,320 --> 00:26:22,060
+الـ Prevention للإنفلوانزا بشكل عام هنرجو انه عشان
+
+328
+00:26:22,060 --> 00:26:27,120
+احنا خلطنا بين انفلوانزا و ركزنا عمين على H5N1 انه
+
+329
+00:26:27,120 --> 00:26:31,480
+نحاول نفصل بينهم تمام؟ هم صحيح اتنين انفلوانزا لكن
+
+330
+00:26:31,480 --> 00:26:36,280
+واحد له special situation اللي هو الـH5N1 لأنه
+
+331
+00:26:36,280 --> 00:26:39,880
+بنالكه highly pathogenic فحاولنا نركز عليه شوية
+
+332
+00:26:39,880 --> 00:26:45,620
+طيب لو انسينا الـH5N1 الآن و نتكلم عن الانفلوانزا
+
+333
+00:26:45,620 --> 00:26:49,640
+بشكل عاممش احنا بنسمع ان في influenza vaccine ال
+
+334
+00:26:49,640 --> 00:26:54,140
+influenza vaccine طب ال influenza vaccine بيحتوي
+
+335
+00:26:54,140 --> 00:26:57,780
+على السلالات البشرية الشائعة اللي هم بتبقى على مين
+
+336
+00:26:57,780 --> 00:27:04,700
+H1 in one H3 in two isolates كمان مرة هم مش اتنين
+
+337
+00:27:04,700 --> 00:27:12,370
+هم سلالات بينتموا لهذه السلالتين يعني في صدلان
+
+338
+00:27:12,370 --> 00:27:18,570
+احنا بقول لكوا بس they undergo antigenic drift،
+
+339
+00:27:18,570 --> 00:27:23,990
+فال vaccine each year is updated، كل سنة بيصيرله
+
+340
+00:27:23,990 --> 00:27:27,730
+updating، ايش يعني updating؟ ايش صار السنة الماضية
+
+341
+00:27:27,730 --> 00:27:32,510
+سلالات جديدة بنجمعها و بنحطها في هذا اللي هو ال
+
+342
+00:27:32,510 --> 00:27:37,680
+vaccine؟طبعا الجمهورية الرقم تلاتة ال vaccine is
+
+343
+00:27:37,680 --> 00:27:44,300
+usually reformulated يعني عاد تشكيله each year to
+
+344
+00:27:44,300 --> 00:27:47,380
+contain the current antigenic strains both killed
+
+345
+00:27:47,380 --> 00:27:51,180
+and live vaccines contain two A strains and one B
+
+346
+00:27:51,180 --> 00:27:55,510
+strain of influenza virusThere are two types of
+
+347
+00:27:55,510 --> 00:27:57,670
+influenza vaccine available في الولايات المتحدة
+
+348
+00:27:57,670 --> 00:28:02,610
+الأول killed vaccine وبيحتوي على ال purified
+
+349
+00:28:02,610 --> 00:28:08,780
+subunits من الفيروسالهيم أجلوتنين والهيم أجلوتنين
+
+350
+00:28:08,780 --> 00:28:15,620
+والهيم
+
+351
+00:28:15,620 --> 00:28:25,360
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+352
+00:28:25,360 --> 00:28:26,380
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+353
+00:28:26,380 --> 00:28:26,720
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+354
+00:28:26,720 --> 00:28:27,080
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+355
+00:28:27,080 --> 00:28:33,840
+أجلوتنين الهيم
+
+356
+00:28:33,840 --> 00:28:36,510
+أجلوتنبيحضروه من خلال inactivation with
+
+357
+00:28:36,510 --> 00:28:40,270
+formaldehyde وعلى فكرة ال formaldehyde استخدمناها
+
+358
+00:28:40,270 --> 00:28:43,330
+أيضا حتى في ال bacterial vaccine فإذا ال
+
+359
+00:28:43,330 --> 00:28:47,850
+formaldehyde مشهور في كل من ال viral و ال
+
+360
+00:28:47,850 --> 00:28:51,410
+bacterial vaccine بعد ال formaldehyde بيستخدموا ال
+
+361
+00:28:51,410 --> 00:28:55,790
+lipid solvent حتى يكسر ال virus و بعدين ناخد منه
+
+362
+00:28:55,790 --> 00:29:00,430
+ال neuroamidase و ال hemeإذا ال prevention في ال
+
+363
+00:29:00,430 --> 00:29:04,650
+influenza لحد الآن معتمد بالدرجة الأولى على مين؟
+
+364
+00:29:04,650 --> 00:29:09,470
+على ال vaccine اللي فيه منه كمان مرة صينفين طب فيه
+
+365
+00:29:09,470 --> 00:29:16,530
+صينف تالت منه؟ درسنا conditional
+
+366
+00:29:16,530 --> 00:29:23,050
+lethal mutation إيش معنى الفيروس هادا؟هذا اللي
+
+367
+00:29:23,050 --> 00:29:26,270
+قلنا عنه بيتكاثر في الأنف و في ال upper
+
+368
+00:29:26,270 --> 00:29:29,570
+respiratory لإن هو نزل لتحت مابقدرش يتكاثر لإن هو
+
+369
+00:29:29,570 --> 00:29:33,470
+temperature sensitive mutant و كذلك يستخدمونه ك
+
+370
+00:29:33,470 --> 00:29:40,650
+spray ك nasal spray طبعا
+
+371
+00:29:40,650 --> 00:29:47,410
+إذا فاكرين قلنا إنه قد نستخدم بعض العقاقير مش فقط
+
+372
+00:29:47,410 --> 00:29:51,840
+لل treatmentأيضًا لمن؟ لـ Prevention مثل
+
+373
+00:29:51,840 --> 00:29:55,260
+الأمانتدين والريمانتدين والأصول تمافير، بينما
+
+374
+00:29:55,260 --> 00:29:59,320
+الـXanamavir جونالكول لم يعتمد لـ Prevention مين
+
+375
+00:29:59,320 --> 00:30:01,780
+اللي ممكن ياخد الفاكسين؟ غالبًا الـ elderly
+
+376
+00:30:01,780 --> 00:30:05,880
+people، الناس اللي فوق الخمسة أو ستين سنة
+
+377
+00:30:08,930 --> 00:30:12,230
+طبعا الأفعال هذه ولا بأي حالة من الأحوال ممكن
+
+378
+00:30:12,230 --> 00:30:16,070
+نستخدمها كبديل عن ال vaccine وما زالت ال
+
+379
+00:30:16,070 --> 00:30:22,370
+immunization هي الطريقة الأكثر يعني فعالية في منع
+
+380
+00:30:22,370 --> 00:30:27,750
+ال diseaseالفيروس التاني اللي هو ال Paramyoxic
+
+381
+00:30:27,750 --> 00:30:30,570
+virus اللي هو مجموعة من الفيروسات طبعا ال
+
+382
+00:30:30,570 --> 00:30:33,990
+orthomyoxic virus أخدنا الممثل عنه الوحيد منه اللي
+
+383
+00:30:33,990 --> 00:30:39,450
+هو ال influenza virus لكن هنا سنتحدث عن مجموعة من
+
+384
+00:30:39,450 --> 00:30:45,110
+الفيروسات تحت عنوان Paramyoxic virus اتلقونا على
+
+385
+00:30:45,110 --> 00:30:51,350
+ال spike هذا بقولنا HN HN يعني بتحتوي على
+
+386
+00:30:52,650 --> 00:30:57,590
+Hemagglutinin و Neuraminidase at the same spike
+
+387
+00:30:57,590 --> 00:31:02,430
+هذا الكلام مار معانا لما عملنا مقارنة بين ال Ortho
+
+388
+00:31:02,430 --> 00:31:08,110
+و Paramyoxivirus طبعا ال M-protein زي ال M-protein
+
+389
+00:31:08,110 --> 00:31:14,310
+اللي هناك اللي هي ال matrix protein طيب هذه
+
+390
+00:31:14,310 --> 00:31:17,410
+المجموعة بالنسبة لنا كانت في يوم من الأيام من
+
+391
+00:31:17,410 --> 00:31:22,440
+المجموعات الخطيرة جدا لانها بتشملقائمة من
+
+392
+00:31:22,440 --> 00:31:26,140
+الفيروسات اللي كانت تسبب أمراض الإنسان قاتلة لو لا
+
+393
+00:31:26,140 --> 00:31:32,360
+وجود ال vaccination لحتفرت بأهميتها بشكل كبير في
+
+394
+00:31:32,360 --> 00:31:37,420
+عالم ال micro biologyIt is composed of one piece
+
+395
+00:31:37,420 --> 00:31:41,620
+of a single stranded RNA, a helical nucleocapsid
+
+396
+00:31:41,620 --> 00:31:45,080
+and outer lipoprotein وبيقول عنها .. بيقول عنها
+
+397
+00:31:45,080 --> 00:31:51,120
+الجينوم تبعها typical of paramoxivirus يعني كلهم
+
+398
+00:31:51,120 --> 00:31:57,980
+الجينوم تبعهم متشابه Negative polarity جينوم موجود
+
+399
+00:31:57,980 --> 00:32:01,600
+معاه RNA dependent RNA polymerase عشان يقدر يحوله
+
+400
+00:32:01,600 --> 00:32:05,860
+من negative sense إلى positive senseوالجينوم بيقول
+
+401
+00:32:05,860 --> 00:32:10,680
+عنه انه ليس infectious السبب انه .. انه مضطر يجيب
+
+402
+00:32:10,680 --> 00:32:14,000
+معاه إشي يبتدى مش infectious الحق ال envelope is
+
+403
+00:32:14,000 --> 00:32:17,000
+covered with spikes which contain hemagglutinin,
+
+404
+00:32:17,360 --> 00:32:20,160
+neuroamylidase او a fusion protein لاحظوا الآن انا
+
+405
+00:32:20,160 --> 00:32:25,900
+بتكلم بعمومية انا الآن بتكلم بالعموم ال spikes اما
+
+406
+00:32:25,900 --> 00:32:28,540
+بتحتوى على hemagglutinin و neuroamylidase او
+
+407
+00:32:28,540 --> 00:32:31,820
+fusion protein هذه ماكانتش موجودة في من؟ في ال
+
+408
+00:32:31,820 --> 00:32:38,200
+orthopoxy virusesوفي بعض الحالات الهيمولاسيس ليس
+
+409
+00:32:38,200 --> 00:32:41,480
+فقط تعمل ال fusion تعمل أيضا الهيمولاسيس لذلك يوجد
+
+410
+00:32:41,480 --> 00:32:44,700
+فيه نيرو امينوديز يوجد فيه مأجلوتنين يوجد فيه فسيل
+
+411
+00:32:44,700 --> 00:32:48,480
+فيوجن يوجد فيه الهيمولاسيس يوجد فيه الـ spike سبعت
+
+412
+00:32:48,480 --> 00:32:59,300
+ال Paramyxivirus بنجسمها إلى تلت مجموعات ال ال ال
+
+413
+00:32:59,300 --> 00:33:00,080
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+414
+00:33:00,080 --> 00:33:00,880
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+415
+00:33:00,880 --> 00:33:01,440
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+416
+00:33:01,440 --> 00:33:03,760
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+417
+00:33:03,760 --> 00:33:03,780
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+418
+00:33:05,580 --> 00:33:10,940
+في حجم مربيلي فيروس ضمن الـ Paramyx Verdi بيضم
+
+419
+00:33:10,940 --> 00:33:15,240
+اللي هو ال missiles أو الربيولا والنيومو فيروس
+
+420
+00:33:15,240 --> 00:33:19,520
+بيضم فيروس اسمه Respiratory syncytial virus إذن ال
+
+421
+00:33:19,520 --> 00:33:25,560
+Paramyx Verdi تشمل تلت sub families اللي هم
+
+422
+00:33:25,560 --> 00:33:30,640
+Paramyx Virus مربيلي فيروس ونيومو فيروس الأسماء
+
+423
+00:33:30,640 --> 00:33:35,470
+اللي قدامكواPrespiratory-sensitive virus, Measles,
+
+424
+00:33:35,890 --> 00:33:41,750
+Mumps, and Parainfluenza virus دعونا نطلع على
+
+425
+00:33:41,750 --> 00:33:48,290
+الفروقات في الـ spikes سبعتهم الميسل
+
+426
+00:33:48,290 --> 00:33:53,370
+فيروس عنده هيم أجليتينين بس ماعندوش نيورو أمينيديز
+
+427
+00:33:53,370 --> 00:33:57,750
+خدينا بس العمودين الأولانية و بعدين نشوف اللي هو
+
+428
+00:33:57,750 --> 00:34:02,920
+العمود التالتالـ Mumps عنده Hemagglutinin و عنده
+
+429
+00:34:02,920 --> 00:34:07,380
+Neuroaminidase الـ Respiratory لا عنده
+
+430
+00:34:07,380 --> 00:34:10,920
+Hemagglutinin ولا عنده Neuroaminidase الـ
+
+431
+00:34:10,920 --> 00:34:16,520
+Parainfluenza زي الـ Mumps فيروس تحتوي على كل من
+
+432
+00:34:16,520 --> 00:34:20,280
+ال Hemagglutinin و Neuroaminidase لكن لاحظوا ال
+
+433
+00:34:20,280 --> 00:34:24,040
+fusion proteinكلهم بيحتوى على fusion ال protein
+
+434
+00:34:24,040 --> 00:34:31,400
+يعني كلهم بيعملوا syncytia بيعملوا ال giant cell
+
+435
+00:34:31,400 --> 00:34:35,940
+اللي في ال cell culture طيب
+
+436
+00:34:35,940 --> 00:34:41,340
+نبدأ بمين؟ بال measles هل تعلموا ان ال measles كان
+
+437
+00:34:41,340 --> 00:34:48,670
+الناس يخافوا منها خوفهم من الطعون؟لأنه يمكن نصف
+
+438
+00:34:48,670 --> 00:34:52,950
+أطفال المنطقة اللي كانت تصاب بال missiles كانوا
+
+439
+00:34:52,950 --> 00:34:58,580
+برضه يموتوافالميسلز من الأمراض الخطيرة جدا و التي
+
+440
+00:34:58,580 --> 00:35:03,720
+أدت إلى يعني خلّيني نقول قتل ملايين من البشر في
+
+441
+00:35:03,720 --> 00:35:08,080
+عصور صادقة بفضل من الله سبحانه وتعالى و بفضل ال
+
+442
+00:35:08,080 --> 00:35:11,240
+vaccine ثم بفضل ال vaccine تم تقريبا القضاء على
+
+443
+00:35:11,240 --> 00:35:15,660
+هذا المرض و أصبح هذه الحالات نادر جدا و إذا كان في
+
+444
+00:35:15,660 --> 00:35:18,940
+حالات غالبا بتكون mild cases لأن ال vaccine بيكون
+
+445
+00:35:18,940 --> 00:35:22,290
+عاملprotection للإنسان إذن ال missiles virus أو
+
+446
+00:35:22,290 --> 00:35:25,730
+الحصبة وبيتبيزوا بين الحصبة و الحصبة الألمانية
+
+447
+00:35:25,730 --> 00:35:28,490
+الحصبة الألمانية اللي هي الربلة برضه واحد من نفس
+
+448
+00:35:28,490 --> 00:35:33,730
+اللي هو العيلة ال missiles أخطر من الربلة ال
+
+449
+00:35:33,730 --> 00:35:37,050
+missiles مثلا في الأم الحامل كانت تؤدي إلى وفاة
+
+450
+00:35:37,050 --> 00:35:41,150
+الجنين لكن الربلة كانت تؤدي إلى تشوهات في الجنين
+
+451
+00:35:41,150 --> 00:35:46,130
+يعني شوفوا كده شدة المرض في ال missiles أعلى بكثير
+
+452
+00:35:46,130 --> 00:35:49,050
+من اللي هو ال .. ال .. ال ..
+
+453
+00:35:52,230 --> 00:35:56,430
+الفيروس يسبب فيه ميسيلات، مخلوق مسموح بـ
+
+454
+00:35:56,430 --> 00:36:00,910
+maculopapular rash، أهم يميزه طفاح جلدي، يحدث
+
+455
+00:36:00,910 --> 00:36:08,070
+أولاً في الطفولة، الخواص العام له الـRNA و
+
+456
+00:36:08,070 --> 00:36:11,450
+الـNucleocapsid ميسيلات، فيروس أرضوس و بطبيكال
+
+457
+00:36:11,450 --> 00:36:12,470
+باراميكسفيروس
+
+458
+00:36:17,410 --> 00:36:20,970
+الـ single-stranded RNA، negative single-stranded
+
+459
+00:36:20,970 --> 00:36:24,230
+RNA، وفيها الـ RNA dependent RNA Polymerase، هاي
+
+460
+00:36:24,230 --> 00:36:27,970
+اللي هم الـ الـ ال typical genome أو الـ virus
+
+461
+00:36:30,050 --> 00:36:37,030
+البيعس لديه اتفاقنات اتفاقنية اتفاقنية
+
+462
+00:36:37,030 --> 00:36:41,630
+اتفاقنية
+
+463
+00:36:41,630 --> 00:36:45,330
+اتفاقنية اتفاقنية اتفاقنية اتفاقنية اتفاقنية
+
+464
+00:36:45,330 --> 00:36:47,710
+اتفاقنية اتفاقنية اتفاقنية اتفاقنية اتفاقنية
+
+465
+00:36:47,710 --> 00:36:54,890
+اتفاقنية اتفاقنية اتفاقنيةنتلقى النبع هذا ببلغ
+
+466
+00:36:54,890 --> 00:36:58,290
+الارتياح ودلها single serotype يعني الفاكسين أحد
+
+467
+00:36:58,290 --> 00:37:01,310
+أسرار نجاح الفاكسين أنه single serotype
+
+468
+00:37:03,650 --> 00:37:07,150
+and hemeagglutinin is the antigen against which
+
+469
+00:37:07,150 --> 00:37:11,250
+neutralizing antibody is directed نفس الكلام اللي
+
+470
+00:37:11,250 --> 00:37:14,670
+حكيناه لمين؟ للإنفلوانزا إنه إذا الجسم مكوّن
+
+471
+00:37:14,670 --> 00:37:18,030
+antibody للهيم أجلوتينين فبيعمل neutralization
+
+472
+00:37:18,030 --> 00:37:21,490
+ليش؟ لأنه الهيم أجلوتينين هو المسؤول عن الإرتباب
+
+473
+00:37:21,490 --> 00:37:25,790
+بالcell surface والاختراق لداخل الخلية فإذا أنا
+
+474
+00:37:25,790 --> 00:37:29,450
+كونت antibody ضده أنا عملت له neutralization منعته
+
+475
+00:37:29,450 --> 00:37:34,410
+من الدخول إلى داخل الخليةhuman are the only
+
+476
+00:37:34,410 --> 00:37:38,070
+natural host for this virus هذا كمان سر من أسرار
+
+477
+00:37:38,070 --> 00:37:40,850
+نجاح من ال vaccine و ال prevention المرة الجاية ان
+
+478
+00:37:40,850 --> 00:37:42,730
+شاء الله نكمل عن هذا ال virus
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e9ae0b4cca722bf6a5f90fb51df4592d4b466b07
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_raw.json
@@ -0,0 +1 @@
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عرضة للإصابة بتكون فيهم severe، اللي هم ال infants الأقل من سنتين، الأقل من سنتين ال immunity اللي بتحدث متكونة من تلت عناصر رئيسية، IGA", "tokens": [995, 33753, 2304, 6027, 10632, 2423, 38688, 1829, 9307, 39894, 30544, 6225, 6027, 10632, 8978, 8032, 33604, 1211, 16606, 2423, 8315, 3794, 12399, 3714, 9957, 9122, 2304, 7649, 6156, 19986, 9307, 12399, 16490, 3215, 8315, 8717, 39648, 5551, 4117, 2655, 2288, 6225, 43042, 3660, 24976, 28814, 9381, 16758, 3660, 39894, 30544, 8978, 16095, 8922, 12399, 13672, 1829, 8032, 2304, 2423, 38829, 16247, 4587, 1211, 9154, 8608, 29399, 9957, 12399, 16247, 4587, 1211, 9154, 8608, 29399, 9957, 2423, 22701, 13672, 1829, 39894, 24401, 12984, 44650, 30544, 3660, 9154, 6055, 1211, 2655, 18871, 33546, 2288, 12602, 19986, 1829, 3794, 10632, 12399, 286, 12570], "avg_logprob": -0.1668198484123922, "compression_ratio": 1.6790697674418604, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1094.34, "end": 1095.08, "word": "احتمالية", "probability": 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Z-stat flu وبيعتمد على استخدام اللي هو ال neuroaminidase، ال neuroaminidase بتعرفين بيكسر جنة اللي هو السيالك أسد فبيحطوا substrate، substrate، هذا ال substrate مرتبط ممين؟ بسيالك أسد analog", "tokens": [2407, 3224, 15730, 9122, 2304, 7649, 13672, 1829, 31439, 1176, 12, 19435, 5029, 4032, 21292, 34268, 2304, 3215, 15844, 44713, 9778, 3215, 10943, 13672, 1829, 31439, 2423, 16499, 7428, 327, 651, 12399, 2423, 16499, 7428, 327, 651, 39894, 3615, 28480, 9957, 4724, 1829, 4117, 3794, 2288, 10874, 1863, 3660, 13672, 1829, 31439, 21136, 1829, 6027, 4117, 5551, 3794, 3215, 6156, 21292, 5016, 9566, 14407, 27585, 12399, 27585, 12399, 23758, 2423, 27585, 3714, 43500, 3555, 9566, 3714, 2304, 9957, 22807, 4724, 3794, 1829, 6027, 4117, 5551, 3794, 3215, 16660], "avg_logprob": -0.25983146335301777, "compression_ratio": 1.643979057591623, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1479.58, "end": 1479.92, "word": "وهذا", "probability": 0.5788981119791666}, {"start": 1479.92, "end": 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chromogene اللي هو ال substrate الملون عن السيالك أسد وبتالي بيطلع عندنا لون مميز، هذا فحص فكرته حلوة ومستخدم أيضا في diagnosis معتمد على مين كم مرة؟ على neuroaminidase", "tokens": [6027, 7649, 45164, 8978, 8978, 32887, 3794, 8978, 9673, 41361, 4032, 5016, 41193, 9957, 47356, 2423, 27585, 23758, 39896, 5172, 36520, 3714, 9957, 22807, 39896, 5172, 36520, 21136, 1829, 6027, 4117, 5551, 3794, 3215, 5296, 33456, 2423, 16499, 669, 259, 299, 8258, 31439, 8608, 1829, 6027, 4117, 5551, 3794, 3215, 12399, 31439, 8608, 1829, 6027, 4117, 5551, 3794, 3215, 12399, 39896, 5172, 36520, 2423, 16209, 664, 1450, 13672, 1829, 31439, 2423, 27585, 9673, 1211, 11536, 18871, 21136, 1829, 6027, 4117, 5551, 3794, 3215, 46599, 2655, 6027, 1829, 4724, 1829, 9566, 1211, 3615, 43242, 8315, 5296, 11536, 3714, 2304, 1829, 11622, 12399, 23758, 6156, 5016, 9381, 6156, 4117, 43500, 3224, 11331, 1211, 2407, 3660, 4032, 2304, 14851, 9778, 40448, 36632, 11242, 995, 8978, 15217, 3714, 34268, 2304, 3215, 15844, 3714, 9957, 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0.9625244140625}, {"start": 2258.07, "end": 2258.33, "word": " نجاح", "probability": 0.9767252604166666}, {"start": 2258.33, "end": 2258.59, "word": " من", "probability": 0.53271484375}, {"start": 2258.59, "end": 2259.21, "word": " ال", "probability": 0.818359375}, {"start": 2259.21, "end": 2259.59, "word": " vaccine", "probability": 0.8828125}, {"start": 2259.59, "end": 2259.83, "word": " و", "probability": 0.80859375}, {"start": 2259.83, "end": 2260.07, "word": " ال", "probability": 0.2396240234375}, {"start": 2260.07, "end": 2260.35, "word": " prevention", "probability": 0.94970703125}, {"start": 2260.35, "end": 2260.59, "word": " المرة", "probability": 0.780029296875}, {"start": 2260.59, "end": 2260.77, "word": " الجاية", "probability": 0.6292317708333334}, {"start": 2260.77, "end": 2260.85, "word": " ان", "probability": 0.5048828125}, {"start": 2260.85, "end": 2261.07, "word": " شاء", "probability": 0.951416015625}, {"start": 2261.07, "end": 2261.25, "word": " الله", "probability": 0.958984375}, {"start": 2261.25, "end": 2261.83, "word": " نكمل", "probability": 0.9508463541666666}, {"start": 2261.83, "end": 2261.93, "word": " عن", "probability": 0.96875}, {"start": 2261.93, "end": 2262.21, "word": " هذا", "probability": 0.96630859375}, {"start": 2262.21, "end": 2262.47, "word": " ال", "probability": 0.2685546875}, {"start": 2262.47, "end": 2262.73, "word": " virus", "probability": 0.81787109375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2263.5740625, "duration_after_vad": 2146.9543749999907}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..dbd7f5d3e18b43f0781d92ce710292e027c41140
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEPIcMm0U7A_raw.srt
@@ -0,0 +1,1928 @@
+1
+00:00:20,790 --> 00:00:23,830
+طيب بسم الله الرحمن الرحيم نكمل ما بدأنا المحاضرة
+
+2
+00:00:23,830 --> 00:00:27,950
+السابقة والمتعلقة بالـRNA Envelope Viruses وبدأنا
+
+3
+00:00:27,950 --> 00:00:31,570
+بالحديث عن أول فيروس بينتمي إلى الـOrthomax
+
+4
+00:00:31,570 --> 00:00:36,230
+Viruses اللي هو الـ Influenza Virus ويمكن آخر شيء
+
+5
+00:00:36,230 --> 00:00:41,880
+تحدثنا فيه اللي هو متعلق بإنه فيه تلت أنواعأو تلت
+
+6
+00:00:41,880 --> 00:00:45,200
+groups اللي هم group A و group B و group C هذا
+
+7
+00:00:45,200 --> 00:00:48,520
+يعني انه كل واحدة منهم تمتلك group antigen لكن كنا
+
+8
+00:00:48,520 --> 00:00:52,060
+فيه كمان type specific antigens و المتبادلة مثلا
+
+9
+00:00:52,060 --> 00:00:58,640
+في ال H و ال N و كنا مثلا ال ال ال الجروب A فيها
+
+10
+00:00:58,640 --> 00:01:04,460
+16 H من 1 إلى 16 ونفس الجروب فيها من 1 إلى 9 من
+
+11
+00:01:04,460 --> 00:01:08,720
+اللي هم ال N وبعدين اتحدث عن بعض التراكيب المتعلقة
+
+12
+00:01:08,720 --> 00:01:12,440
+بال matrix protein 1 و matrix protein 2 M1 و M2
+
+13
+00:01:12,440 --> 00:01:17,480
+وجودنا الأولاني هو structural بنائي بيعمل support
+
+14
+00:01:17,480 --> 00:01:22,800
+للمنبرين مع الكبسيد والثاني ب forms ion channel
+
+15
+00:01:22,800 --> 00:01:26,310
+وال ion channel جودنا مهمة جدا في عملية اللي هوالـ
+
+16
+00:01:26,310 --> 00:01:30,370
+Uncoating للفيروس لما يدخل داخل الخلية لكن هناك
+
+17
+00:01:30,370 --> 00:01:33,830
+أيضًا بروتين بنسميه non-structural لما نقول non
+
+18
+00:01:33,830 --> 00:01:36,710
+-structural لغاية ما نقصد فيها ان هو functional
+
+19
+00:01:36,710 --> 00:01:41,890
+يعني له function رئيسي اللي هو اللي سمينا NS1 ال
+
+20
+00:01:41,890 --> 00:01:47,870
+NS1 له طريقة رهيبة جدًا في ال virulence كيف
+
+21
+00:01:47,870 --> 00:01:52,790
+بيشتغل؟ بتعرفوا أن ال interferon هو أحد ال innate
+
+22
+00:01:52,790 --> 00:01:58,020
+immunity against virusesضد الفيروسات الـ
+
+23
+00:01:58,020 --> 00:02:00,720
+interferon بنبّي الخلايا الأخرى و بيخلّيها more
+
+24
+00:02:00,720 --> 00:02:04,160
+alert more immune to viral infection مين اللي
+
+25
+00:02:04,160 --> 00:02:07,380
+بيفرز ال interferon؟ نفس الخلايا المصادرة بالفيروس
+
+26
+00:02:07,380 --> 00:02:11,800
+عشان يصير فينا production ل interferon لازم يصير
+
+27
+00:02:11,800 --> 00:02:16,220
+فينا transcription ل mRNA عشان يصير translation لل
+
+28
+00:02:16,220 --> 00:02:20,400
+interferon اللي هو ال protein حضرة ال NS1 اللي هو
+
+29
+00:02:20,400 --> 00:02:23,540
+ال non structural protein one بيعمل عملية
+
+30
+00:02:23,540 --> 00:02:27,600
+inhibition لمين؟لـ Production of mRNA تبع الـ
+
+31
+00:02:27,600 --> 00:02:30,860
+Interferon يعني بيبنع تكوين الـ Interferon من
+
+32
+00:02:30,860 --> 00:02:35,600
+المادة وسط الصورة إذا هذه الـ Viability تبع اللي
+
+33
+00:02:35,600 --> 00:02:43,720
+هو الـ NS1 الآن ننتقل إلى فكرة أنه فيروس بيصيب
+
+34
+00:02:43,720 --> 00:02:48,760
+مخلوقات مختلفة مثلا لما بنقول waterfall أو water
+
+35
+00:02:48,760 --> 00:02:52,760
+birds إيش يعني water birds الطيور المائية الطيور
+
+36
+00:02:52,760 --> 00:02:53,700
+المائية إيش بتعرفوا عنها
+
+37
+00:02:58,130 --> 00:03:02,690
+الحقيقة انه هناك مئات ال species من هذا البط اللي
+
+38
+00:03:02,690 --> 00:03:05,630
+بنتكلم عنه أو اللي بيسميه water birds او water
+
+39
+00:03:05,630 --> 00:03:10,270
+fowl، بنتكلم عن horses، بنتكلم عن swans، خنازير،
+
+40
+00:03:10,270 --> 00:03:14,770
+هذه كلها species اللي لها specific strains اللي
+
+41
+00:03:14,770 --> 00:03:20,470
+بتصيبش الإنسانما بتصيبش الانسان وبالتالي ربما ..
+
+42
+00:03:20,470 --> 00:03:24,930
+ربما يصيب الحصان وما يصيب الخنزير والانسان ..
+
+43
+00:03:24,930 --> 00:03:27,390
+الفيروس يصيب الانسان وما يصيب الخنزير يعني في عقل
+
+44
+00:03:27,390 --> 00:03:31,270
+مشترك وقلنا لكوا ان ممكن للانسان او فيروسات
+
+45
+00:03:31,270 --> 00:03:37,110
+الانسان تكتسب H جديدة او N جديدة من وين؟ من مصادر
+
+46
+00:03:37,110 --> 00:03:40,370
+اخرى حيوانية هذا الكلام ماتصيرش الا في group A
+
+47
+00:03:40,370 --> 00:03:43,910
+group B مابصيرش فيها الكلام هذا ليش؟ لأنها تصيب
+
+48
+00:03:43,910 --> 00:03:49,660
+الا الانسانوصل الصورة لما يكون في مصادر أخرى لل H
+
+49
+00:03:49,660 --> 00:03:54,780
+وال N من حيوانات أو طيور مائية قد تنتقل إلى
+
+50
+00:03:54,780 --> 00:03:57,800
+الإنسان عبر التقن اللي كنا نقول عنها reassortment
+
+51
+00:03:57,800 --> 00:04:01,080
+إنه اتنين فيروس يعمل infection ل one single cell
+
+52
+00:04:01,080 --> 00:04:05,060
+ويصير في exchange لل DNA segment أو fragment
+
+53
+00:04:10,830 --> 00:04:14,930
+ده كان من 16 type من الـ HA و جداش من الـ NA اللي
+
+54
+00:04:14,930 --> 00:04:21,410
+هم 9 types في البنادمين في البشر غالبا H1 و H2 و
+
+55
+00:04:21,410 --> 00:04:25,610
+H3 هم المسيطرين هم ال dominant يعني ال predominant
+
+56
+00:04:25,610 --> 00:04:29,230
+و ال N1 و N2 من ال neuroimmunization يبقى فيه
+
+57
+00:04:29,230 --> 00:04:33,900
+تلاتة H و فيه اتنين Nفمثلا عندنا ال influenza
+
+58
+00:04:33,900 --> 00:04:37,840
+virus type B only human virus عشان انا قلنالكوا
+
+59
+00:04:37,840 --> 00:04:41,460
+مافيش امكانية الاكتساب H جديدة او N جديدة من
+
+60
+00:04:41,460 --> 00:04:46,060
+المخلوقات اخرى يبقى بيه مايصيرلوش antigenic shift
+
+61
+00:04:46,060 --> 00:04:50,860
+ايش بيصيرله؟ antigenic drift ايش drift؟هو تغيير
+
+62
+00:04:50,860 --> 00:04:57,140
+طفيف في الـ Antigen Structure، وأنا أؤكد مرة أخرى
+
+63
+00:04:57,140 --> 00:05:01,460
+هنا بأن تأثير الـ Antigenic Drift أو الـ Shift ما
+
+64
+00:05:01,460 --> 00:05:06,360
+بنقدرش نحكم عليهم من أكتر خطورة، لكن التغيير
+
+65
+00:05:06,360 --> 00:05:10,940
+الدراماتيكي معروف وموجود في الـ Shift، تغيير طفيف
+
+66
+00:05:10,940 --> 00:05:12,880
+في اللي هو الـ Antigenic Drift
+
+67
+00:05:16,940 --> 00:05:20,600
+فاكرين في الجدول اللي شوفنا فيه السنوات تبع
+
+68
+00:05:20,600 --> 00:05:24,060
+الأوبئة؟ شوفنا ال prototype virus وشوفنا كيف ال
+
+69
+00:05:24,060 --> 00:05:28,140
+nominclature اللي هي تسمية للفيروسات فمثلا هنا A
+
+70
+00:05:28,140 --> 00:05:32,140
+تعني فيروس A Philippines يعني انتشر فيه الفلبين
+
+71
+00:05:32,140 --> 00:05:36,260
+سنة الف وتسعمائة واتنين وتمانين والسلالة المسببة
+
+72
+00:05:36,260 --> 00:05:42,200
+واطلعة على الرقم لل H و ال N في هذه السلالة H3 N2
+
+73
+00:05:42,200 --> 00:05:50,310
+هل خرجنا من المعروف؟ H1H2 H3 N1 N2 هاي اللي هم
+
+74
+00:05:50,310 --> 00:05:56,670
+الخمسة هذا لا يعني انه فيش غيرهم احنا شوفنا H5 N1
+
+75
+00:05:56,670 --> 00:06:02,650
+وحنشوف كمان شوية كمان H7 لكن هذه السلالات أصلا من
+
+76
+00:06:02,650 --> 00:06:06,490
+أين جاية من الطيور جاية من الطيور مش من ال human
+
+77
+00:06:08,630 --> 00:06:10,670
+طبعا التفسير اللي قوله كل الكلام اللي قولته هنا
+
+78
+00:06:10,670 --> 00:06:15,570
+تفسير ليه اللي هو تسمية جنة A هو type A اتطلعوا
+
+79
+00:06:15,570 --> 00:06:23,710
+يعرفوا عدد الوفيات هم 226 ضعيف بنسبة وفيات 63%
+
+80
+00:06:23,710 --> 00:06:28,790
+يعني من أعلى نسب القتل لكل الفيروسات والبكتيريا
+
+81
+00:06:28,790 --> 00:06:35,140
+اللي بنعرفها في الوقت الحالي 63% حالات وفياتالان
+
+82
+00:06:35,140 --> 00:06:40,020
+الخطورة كمان مرة ان هذه السلالة highly pathogenic
+
+83
+00:06:40,020 --> 00:06:46,200
+الفيرالينس بتاعها عالي جدا لكن الشئ المطمئن انها
+
+84
+00:06:46,200 --> 00:06:49,020
+مابتنتقلش من انسان الى انسان
+
+85
+00:06:51,630 --> 00:06:57,050
+اللي بيصاب فيها غالبا بيصاب بعد intense exposure
+
+86
+00:06:57,050 --> 00:07:02,750
+يعني تعرض كثيف للفيروس احتكاك مباشر مع الدواجن
+
+87
+00:07:02,750 --> 00:07:06,730
+المصابة وقد يكون الاحتكاك لفترات طويلة وحنحاول
+
+88
+00:07:06,730 --> 00:07:11,710
+نفسر ليش بتصيب الدواجن وبتصيبش الإنسان وإن أصابت
+
+89
+00:07:11,710 --> 00:07:15,630
+الإنسان فقط بتصيروا بعد انها intense exposure زي
+
+90
+00:07:15,630 --> 00:07:22,370
+ما ذكرناأخر جملة في اللوحة بتقول ان الـ Spread of
+
+91
+00:07:22,370 --> 00:07:25,650
+H5 in one strain from person to person occurs
+
+92
+00:07:25,650 --> 00:07:30,650
+rarely، نادرا ما حصل، والحقيقة أن حتى الدراسة اللي
+
+93
+00:07:30,650 --> 00:07:34,470
+ذكرت أنه في انتقال من إنسان إلى إنسان، هذه الدراسة
+
+94
+00:07:34,470 --> 00:07:37,750
+was not supported، لم تدعم من أي دراسة أخرى،
+
+95
+00:07:37,750 --> 00:07:42,330
+وبالتالي لحد الآن الخط اللي بنعرفه أنه بتنتقل من
+
+96
+00:07:42,330 --> 00:07:45,950
+الدواجن إلى الإنسان وليس من إنسان إلى إنسان
+
+97
+00:07:49,430 --> 00:07:56,090
+في 2005 الـ H5N1 انتشر من آسيا ورقع سيبيريا وعلى
+
+98
+00:07:56,090 --> 00:08:02,390
+أوروبا الشرقية هناك الفيروس قتل thousands of birds
+
+99
+00:08:02,390 --> 00:08:09,390
+لكن لم يصب البنادمين بأي حالة avian flu في 2008 لم
+
+100
+00:08:09,390 --> 00:08:11,110
+تسجل أي حالة
+
+101
+00:08:15,900 --> 00:08:19,320
+حالة بشرية للـ avian flu في الولايات المتحدة لكن
+
+102
+00:08:19,320 --> 00:08:26,580
+في ال 2005 اه عفوا في نفس السنة كان هناك حالتين
+
+103
+00:08:26,580 --> 00:08:33,720
+بشريات من ال influenza سببهم strain جديد اسمه H7N2
+
+104
+00:08:33,720 --> 00:08:37,980
+والـ H7N2 هو ايضا avian influenza
+
+105
+00:08:47,400 --> 00:08:53,660
+الحاجز اللى كان بيننا وبين الطيور يزول يزول هذا
+
+106
+00:08:53,660 --> 00:08:58,420
+الحاجز طبعا البعض بيقول ان احنا في ضل التقدم
+
+107
+00:08:58,420 --> 00:09:03,080
+التكنولوجي والمدن وابتعدنا عن الزراع ان احنا
+
+108
+00:09:03,080 --> 00:09:09,180
+بعيدين عن الحيواناتاحنا بنحتكب الحيوانات شئنا ام
+
+109
+00:09:09,180 --> 00:09:13,840
+قبينا تمام من خلال الغذاء من خلال الغذاء الحيوانات
+
+110
+00:09:13,840 --> 00:09:19,720
+تشكل جزء كبير من غذانا فى حد ما بيستحقش دواجن طب
+
+111
+00:09:19,720 --> 00:09:23,000
+الدواجن هي اللى هي اللى ممكن ايه تنقلنا ال avian
+
+112
+00:09:23,000 --> 00:09:31,590
+fluاحتكاكنا بالحياة لم يقل ربما صار اقل ظهورا اقل
+
+113
+00:09:31,590 --> 00:09:35,670
+شيوعا لكن ما زال منتشر بشكل كبير باشكال اخرى من
+
+114
+00:09:35,670 --> 00:09:42,170
+خلال الغذاء في شيء لطيف في ال 2005 حصل نبشوا على
+
+115
+00:09:42,170 --> 00:09:46,890
+جثة من اللي توفوا في ال 1918 اللي هو متوان الحمة
+
+116
+00:09:46,890 --> 00:09:51,710
+او الانفلوانزا الإسبانية في منطقة من المناطق اللي
+
+117
+00:09:51,710 --> 00:09:57,260
+هي دائما فيها جليدفأخذوا الجثة وحللوا الفيروس اللي
+
+118
+00:09:57,260 --> 00:10:03,900
+موجود في الرئتين تبع الإنسان المتوفق من الحمّة
+
+119
+00:10:03,900 --> 00:10:10,040
+الإسبانية لجوا إن السلالة تبعته تشبه إلى حد كبير
+
+120
+00:10:10,040 --> 00:10:12,220
+H5N1
+
+121
+00:10:13,540 --> 00:10:17,540
+يعني الفرق اللي بين اللي بين الحُمّة هذه و الحُمّة
+
+122
+00:10:17,540 --> 00:10:21,020
+هذه ان هذه الكلمة تنتقل من إنسان لإنسان وهذه لا
+
+123
+00:10:21,020 --> 00:10:25,960
+تنتقل إلا من الدواجن إلى الإنسان فلو صار فيه تغيير
+
+124
+00:10:25,960 --> 00:10:31,160
+يمكن هذا الفيروس من تخطي هذا الحجز يبقى معناه
+
+125
+00:10:31,160 --> 00:10:35,020
+الحكي إمكانية انتشاره في العالم و قتله لأعداد
+
+126
+00:10:35,020 --> 00:10:40,000
+كبيرة هتكون إمكانية مرتفعة جدا وهذه المرة هتكون
+
+127
+00:10:40,000 --> 00:10:44,950
+أصعب ليش؟في 1918 ماكانش فيه سهولة التنقل اللي
+
+128
+00:10:44,950 --> 00:10:49,310
+اليوم موجودة في هذا العالم وبالتالي الاعتقاد ان
+
+129
+00:10:49,310 --> 00:10:53,630
+يكون فيه انتشار واسع يعني بيكون اكبر من ذي قبل
+
+130
+00:10:53,630 --> 00:10:59,350
+الان نفسر لماذا ال H5N1 بصيب الدواجن وما بصيبش
+
+131
+00:10:59,350 --> 00:11:04,170
+البرادمين لجوا ان ال receptors لهذا الفيروس موجودة
+
+132
+00:11:04,170 --> 00:11:08,960
+في كل ال respiratory tract بعتمين تحت الدواجنلكن
+
+133
+00:11:08,960 --> 00:11:13,860
+احنا كبشر نمتلك ال receptors وين؟ نمتلكها فقط في
+
+134
+00:11:13,860 --> 00:11:17,540
+ال alveoli فعشان ال virus يعمل infection لازم نسأل
+
+135
+00:11:17,540 --> 00:11:19,740
+وين؟ ال alveoli وانتوا عارفين ان احنا عندنا
+
+136
+00:11:19,740 --> 00:11:24,220
+ميكانيزم تطرد دايما ايه؟ الفيروسات الا اذا كان
+
+137
+00:11:24,220 --> 00:11:28,980
+كمان مرة التعرض intense اشيان intense كثيف يعني
+
+138
+00:11:28,980 --> 00:11:35,040
+وصل ال alveoli من كثرة مكان موجود الفيروس في
+
+139
+00:11:35,040 --> 00:11:37,320
+الهواء او في ال environment
+
+140
+00:11:41,950 --> 00:11:47,390
+طيب ليش هذا ال strain بالذات more violent و نسبة
+
+141
+00:11:47,390 --> 00:11:50,690
+القتل عنده عالية جدا؟ بقولنا فيه سببين احنا
+
+142
+00:11:50,690 --> 00:11:55,090
+عرفناهم، سببين عرفناهم، واحد it's relative
+
+143
+00:11:55,090 --> 00:11:57,850
+resistance to interferon، عشان اقولنا بيجيب شوي ال
+
+144
+00:11:57,850 --> 00:12:02,670
+influenza بتمنع تكون ال interferon، هذا لو ال
+
+145
+00:12:02,670 --> 00:12:09,460
+interferon متكون أصلا resistant لهرقم اتنين
+
+146
+00:12:09,460 --> 00:12:14,420
+بيستثير جهاز المناعة من خلال الـ cytokine
+
+147
+00:12:14,420 --> 00:12:18,420
+production بيعمل induction للـ cytokines وانا يمكن
+
+148
+00:12:18,420 --> 00:12:23,060
+في هذا ال course بالذات اكثر من عشر مرات اكدت على
+
+149
+00:12:23,060 --> 00:12:30,310
+ان معظمالأعراض والضرر الناتج عن الأمراض الفيروسية
+
+150
+00:12:30,310 --> 00:12:33,350
+بيكون ناتج عن مش الفيروس نفسه وانما عن جهاز
+
+151
+00:12:33,350 --> 00:12:37,410
+المناعة attacking the virally infected cells فلما
+
+152
+00:12:37,410 --> 00:12:41,010
+بيصير فيه cytokines جهاز المناعة بييجي وبيعمل ال
+
+153
+00:12:41,010 --> 00:12:44,450
+damage له ممكن يعمل حاجة اسمها acute respiratory
+
+154
+00:12:44,450 --> 00:12:48,610
+distress syndrome وهذا يعني سيء للغاية وممكن يؤدي
+
+155
+00:12:48,610 --> 00:12:52,130
+الى الوفاة في مرضى ال H5N1
+
+156
+00:13:06,220 --> 00:13:11,080
+هنا نجيب نتكلم عن العقاقيل المستخدمة في العلاج
+
+157
+00:13:11,080 --> 00:13:15,500
+هناك نوعية من العقارات أو العقاقيل عفوا عقارات
+
+158
+00:13:15,500 --> 00:13:20,590
+بتصير real estateالعقاقير فيهم دي حاجة اسمها
+
+159
+00:13:20,590 --> 00:13:24,230
+neuroaminidase inhibitors اللي هي الموانع او
+
+160
+00:13:24,230 --> 00:13:27,390
+مثبتات ال neuroaminidase وكلكوا بتعرفوا ان ال
+
+161
+00:13:27,390 --> 00:13:33,210
+neuroaminidase له وظيفة نهائية في قص الفيروس عن
+
+162
+00:13:33,210 --> 00:13:37,870
+الخلية المصابة فصلها عن الخلية المصابةالان الـ
+
+163
+00:13:37,870 --> 00:13:40,370
+Neuraminidase Inhibitor بعد الحاجة الـ
+
+164
+00:13:40,370 --> 00:13:43,910
+Neuraminidase مش هيشتغل مش هيقص اللي هو ال .. ال
+
+165
+00:13:43,910 --> 00:13:48,490
+virus فهيدله منتصق بمين؟ بالخلية المصابة يبقى لان
+
+166
+00:13:48,490 --> 00:13:53,510
+ينتقل الى خلايا أخرى وهذا بيقلل من المرض و طبعا
+
+167
+00:13:53,510 --> 00:13:58,170
+بتدريج بروح ال disease في اسمين مشهورين جدا و
+
+168
+00:13:58,170 --> 00:14:04,300
+سورتاميفير والتاني زنامفيرالاسم التجارة الأول
+
+169
+00:14:04,300 --> 00:14:08,580
+Tamiflu وهذا الاسم هو الأشهر على وجه الأرض كان في
+
+170
+00:14:08,580 --> 00:14:13,020
+الفين و خمسة و الفين و ستة لما كان المرض بيلفلف في
+
+171
+00:14:13,020 --> 00:14:16,720
+الدنيا و الناس خايفة منه فكان شركات الأدوية أو
+
+172
+00:14:16,720 --> 00:14:21,900
+شركة الأدوية المصنعة باعت كميات ضخمة منه كل الدول
+
+173
+00:14:21,900 --> 00:14:27,560
+اشترت تخزن تحصب لوجود حالات يعني من هذا ال disease
+
+174
+00:14:29,750 --> 00:14:33,070
+يبقى الـ H5N1 sensitive للعقارين اللي هم مشكلة
+
+175
+00:14:33,070 --> 00:14:39,290
+مارسهمهمOseltamivir وXanamivir بينما resistant to
+
+176
+00:14:39,290 --> 00:14:41,950
+the drugs that inhibit entry انتوا عارفين ان ال
+
+177
+00:14:41,950 --> 00:14:48,650
+entry للفيروس برضه عملية مهمة الان ال H5N1 دون عن
+
+178
+00:14:48,650 --> 00:14:54,490
+ال others مقاوم لل drugs اللى بتستخدم لمنا دخول
+
+179
+00:14:54,490 --> 00:14:57,490
+الفيروس اللى هم ال Amantadine وRamantadine اذا
+
+180
+00:14:57,490 --> 00:15:01,370
+Ramantadine وAmantadine هى resistant لهمطبعا
+
+181
+00:15:01,370 --> 00:15:04,490
+التامي فلو هو drug of choice للعلاج و لل
+
+182
+00:15:04,490 --> 00:15:07,150
+prevention يعني بمعنى اخر لو واحد صار عنده
+
+183
+00:15:07,150 --> 00:15:10,890
+exposure و بنعمله prophylaxis بنعطيه برضه تمي فلو
+
+184
+00:15:10,890 --> 00:15:13,950
+بالنسبة
+
+185
+00:15:13,950 --> 00:15:16,790
+لل vaccination مافيش vaccine .. مافيش vaccine
+
+186
+00:15:16,790 --> 00:15:20,750
+human vaccine لكن في animal vaccine بمعنى انه
+
+187
+00:15:20,750 --> 00:15:24,630
+بنعطيه دواجن H5N1 vaccine
+
+188
+00:15:29,780 --> 00:15:32,860
+كثير من الكلام المذكور هنا مقرر لكن لا بقص انه
+
+189
+00:15:32,860 --> 00:15:36,940
+انكرر بعض المعلومات لاجل ترسيخها في الأذهان ان شاء
+
+190
+00:15:36,940 --> 00:15:40,820
+الله الانتقال عبر ال respiratory droplets
+
+191
+00:15:43,060 --> 00:15:46,500
+ال epidemics او ال pandemics بتحدث متى يا جماعة؟
+
+192
+00:15:46,500 --> 00:15:51,920
+بتحدث عندما يكون السكان في منطقة معينة ليس لديهم
+
+193
+00:15:51,920 --> 00:15:57,580
+مناعة او اي نوع من المناعة ضد السلالة التي ستسبب
+
+194
+00:15:57,580 --> 00:16:03,760
+هذا الوباء كمان مرة انديفيروس أصاب مجموعة من البشر
+
+195
+00:16:03,760 --> 00:16:07,840
+وشوفوا منه هل الفيروس هذا بيقدر يعمل epidemic مرة
+
+196
+00:16:07,840 --> 00:16:10,840
+تانية فيهم؟بقدرش أعمل epidemic مرة تانية فيها،
+
+197
+00:16:10,840 --> 00:16:15,960
+ليش؟ لأنهم كوّنوها مناعة أنا بجيب مثال دايما واضح
+
+198
+00:16:15,960 --> 00:16:22,400
+ال smallpox قضية عليه سنة 1977 يعني كلنا احنا لم
+
+199
+00:16:22,400 --> 00:16:27,980
+نصب قبل ذلك ولم نطعم ضد هذا الفيروس لو اليوم
+
+200
+00:16:27,980 --> 00:16:32,720
+الفيروس رجع مرة تانية احنا مؤهلين ان يصير لنا وباء
+
+201
+00:16:32,720 --> 00:16:36,850
+ولا مش مؤهلين؟عارفين ليش مؤهلين؟ لأن ولا واحد فينا
+
+202
+00:16:36,850 --> 00:16:40,750
+بيمتلك منع تذكر ال herd immunity او ال community
+
+203
+00:16:40,750 --> 00:16:44,890
+immunity ان الناس المطعمين بيقللوا فرص الناس الغير
+
+204
+00:16:44,890 --> 00:16:48,330
+مطعمين في الإصابة لكن احنا مافيش حد مطعم أساسا
+
+205
+00:16:48,330 --> 00:16:52,510
+وبالتالي فرصة ان يحدث وباء ان يحدث وباء بتكون
+
+206
+00:16:52,510 --> 00:16:58,200
+عالية جدا، إذا متى؟يمكن للانفلونزا ان تحدث هبط
+
+207
+00:16:58,200 --> 00:17:03,640
+عندما يكون التغيير في الانتيجينات تراها كافي ان
+
+208
+00:17:03,640 --> 00:17:08,060
+ولا واحد في المنطقة عنده antibody لهذا الانتيجين،
+
+209
+00:17:08,060 --> 00:17:12,340
+يعني صار تغيير اما drift او shift لهذا الانتيجين
+
+210
+00:17:20,440 --> 00:17:23,720
+الجملة التانية في الفقرة بتقول ان influenza occurs
+
+211
+00:17:23,720 --> 00:17:27,460
+primarily in the winter months اللي دي الأشهر اللي
+
+212
+00:17:27,460 --> 00:17:34,580
+طبعا بدأنا احضروا أنفسكم ليها ال influenza when it
+
+213
+00:17:34,580 --> 00:17:37,620
+and bacterial pneumonia secondary to influenza
+
+214
+00:17:37,620 --> 00:17:40,500
+causes significant number of deaths especially in
+
+215
+00:17:40,500 --> 00:17:44,220
+older people في ممكن في حد المحاضرة اتكلمنا عن
+
+216
+00:17:44,220 --> 00:17:47,920
+five percent mortality rate صح؟ وبنالكوا في مين
+
+217
+00:17:47,920 --> 00:17:52,520
+هذه؟ في ال old ageما هي السبب في الـ old age؟ شكله
+
+218
+00:17:52,520 --> 00:17:57,080
+تاني إن هما منعتهم بالفعل منخفضة واحتمالية الـ
+
+219
+00:17:57,080 --> 00:17:59,840
+complication إنه مش بس تكون upper respiratory
+
+220
+00:17:59,840 --> 00:18:04,860
+tract تنزل وتعمل نيومونيا عالية والاحتمالية الأخرى
+
+221
+00:18:04,860 --> 00:18:09,360
+إن يصاب الإنسان ب secondary bacterial pneumonia زي
+
+222
+00:18:09,360 --> 00:18:12,420
+Staphylococcus aureus
+
+223
+00:18:14,340 --> 00:18:17,480
+احتمالية الوفيات بتكون عالية في هؤلاء الناس، مين
+
+224
+00:18:17,480 --> 00:18:23,000
+كمان فئات، خدنا نقول أكتر عرضة للإصابة بتكون فيهم
+
+225
+00:18:23,000 --> 00:18:26,180
+severe، اللي هم ال infants الأقل من سنتين، الأقل
+
+226
+00:18:26,180 --> 00:18:31,740
+من سنتين ال
+
+227
+00:18:31,740 --> 00:18:37,360
+immunity اللي بتحدث متكونة من تلت عناصر رئيسية،
+
+228
+00:18:37,360 --> 00:18:42,680
+IGAوال IGA is protective ليش protective؟ لأن هو
+
+229
+00:18:42,680 --> 00:18:45,780
+اللي بيحمي الميوكاس membrane والفيروس أصلا بيدخل
+
+230
+00:18:45,780 --> 00:18:50,480
+عبر الميوكاس membrane وبالتالي وجود IGA غالبا
+
+231
+00:18:50,480 --> 00:18:57,300
+بيكون protective لكن أيضا الجسم بينتج IGG وهو
+
+232
+00:18:57,300 --> 00:19:01,120
+يساعد لكن less protective يعني لو افترضنا أن ال
+
+233
+00:19:01,120 --> 00:19:05,620
+IGA مش موجود وال IGG موجود مابيحميناش من مين من
+
+234
+00:19:05,620 --> 00:19:10,050
+الانفلوانزلكن الدور الأعظم كما تعلمون لـ cytotoxic
+
+235
+00:19:10,050 --> 00:19:17,310
+T cell في نقطة أهم جدا اللي بتميز ال influenza عن
+
+236
+00:19:17,310 --> 00:19:21,110
+الرشح
+
+237
+00:19:22,530 --> 00:19:27,630
+إنه فيه ألم في العضلات و ألم العضلات ناتج عن
+
+238
+00:19:27,630 --> 00:19:31,050
+فاكرين جاب شويه جون انه في induction ل cytokines
+
+239
+00:19:31,050 --> 00:19:35,070
+ال cytokines و هي بتلفلف في الدم بتعمل induction
+
+240
+00:19:35,070 --> 00:19:45,730
+للألم اللي احنا بسميه ماليجي أو ألم في العضلات ال
+
+241
+00:19:45,730 --> 00:19:49,780
+incubation period ل disease is very shortقصيرة جدا
+
+242
+00:19:49,780 --> 00:19:54,420
+من 24 ساعة ل 48 ساعة ويمكن البعض منكم ملاحظ هذه
+
+243
+00:19:54,420 --> 00:19:59,720
+الملاحظة انه مابين فترة شعوره بأنه بده يمرض لحين
+
+244
+00:19:59,720 --> 00:20:04,020
+ظهور الأعراض في ال influenza غالبا بتكون قد ساعات
+
+245
+00:20:04,020 --> 00:20:08,200
+يعني مثلا الظهر روح تعبان نامله ساعة زمن بصحى كل
+
+246
+00:20:08,200 --> 00:20:13,340
+الأعراض موجودة من حرارة من رشح اللي هو ال ال ال
+
+247
+00:20:13,340 --> 00:20:17,300
+sneezing من ألم في المفاصل ألم في العضلات كلها
+
+248
+00:20:17,300 --> 00:20:22,910
+ممكن تكونموجودة بشكل سريع لذلك they can develop a
+
+249
+00:20:22,910 --> 00:20:31,070
+suddenly يعني بشكل فجأة حسب ما على بعضكم في دياريا
+
+250
+00:20:31,070 --> 00:20:36,020
+و vomiting في ال influenza؟فيه بس in rare cases ..
+
+251
+00:20:36,020 --> 00:20:39,400
+in rare cases بتكون associated with بالفعل اللي هو
+
+252
+00:20:39,400 --> 00:20:43,660
+influenza من أسوأ ال complications زي ما ذكرنالكم
+
+253
+00:20:43,660 --> 00:20:47,640
+اللي هو ال .. ال Staphylococcal aureus .. aureus
+
+254
+00:20:47,640 --> 00:20:51,860
+ال pneumonia غالبا بتصاحب الحالات ال influenza
+
+255
+00:20:51,860 --> 00:20:56,040
+طبعا ال recovery بيكون من أربع إلى سبع أيام في ال
+
+256
+00:20:56,040 --> 00:21:00,310
+normal peopleالناس العاديين بيشوفوا بدون أي حاجة
+
+257
+00:21:00,310 --> 00:21:06,530
+من أربع إلى سبعية لكن وجود influenza أو bacterial
+
+258
+00:21:06,530 --> 00:21:11,710
+pneumonia بيعقد مسار المرض و قد يوطيله لعدة أسابيع
+
+259
+00:21:11,710 --> 00:21:17,710
+و قد يؤدي كما ذكرنا إلى الوفاة هذه الفقرة تم
+
+260
+00:21:17,710 --> 00:21:22,550
+دراستها سابقا في فيروس اسمه chickenpox صح؟ raise
+
+261
+00:21:22,550 --> 00:21:29,090
+syndrome هذكركم بالاسبارين؟عدم تناول الاسبرين في
+
+262
+00:21:29,090 --> 00:21:34,130
+حالتان إذا كان ال influenza من نوع B أو في حالة ال
+
+263
+00:21:34,130 --> 00:21:38,110
+Varicella Zoster بيصير فيانا two conditions أو two
+
+264
+00:21:38,110 --> 00:21:41,950
+symptoms سevere encephalopathy و liver
+
+265
+00:21:41,950 --> 00:21:47,640
+degeneration هو rare disease لكنهvery خلّينا نقول
+
+266
+00:21:47,640 --> 00:21:51,920
+live threatening يهدد حياة الناس خاصة في الأطفال
+
+267
+00:21:51,920 --> 00:21:54,900
+اللي يصابوا بال viral infection اللي يكون عنها
+
+268
+00:21:54,900 --> 00:21:59,460
+influenza B و chickenpox طبعا ال mechanism by
+
+269
+00:21:59,460 --> 00:22:03,100
+which aspirin produces this disease is not
+
+270
+00:22:03,100 --> 00:22:08,560
+understood لكن هي ملاحظة لذلك ال aspirin لا يُعطى
+
+271
+00:22:08,560 --> 00:22:11,780
+في حالة ال influenza ولا في حالة ال chickenpox
+
+272
+00:22:14,950 --> 00:22:17,970
+الـ lab diagnosis يا جماعة، في حدا فيكم بيعرفش شخص
+
+273
+00:22:17,970 --> 00:22:22,050
+الـ influenza؟ انتوافي حداتيكوا باعرفش شخص
+
+274
+00:22:22,050 --> 00:22:27,850
+الانفلوانزا؟ متهيألي الطباء بشخصه الانفلوانزا
+
+275
+00:22:27,850 --> 00:22:32,010
+clinically بمعنى ان هو مش محتاج هو فحوصات لكن و مع
+
+276
+00:22:32,010 --> 00:22:36,110
+ذلك بنقولكوا انه هناك العديد من الفحوصات المتوفرة
+
+277
+00:22:36,110 --> 00:22:39,570
+للانفلوانزا و بتتاخد للكشف عن الفيروس في ال
+
+278
+00:22:39,570 --> 00:22:42,770
+secretions اللي هو ال nasal secretion او ال throat
+
+279
+00:22:42,770 --> 00:22:47,700
+washing او ال sputumوبنستخدم فيها تقنيات مختلفة
+
+280
+00:22:47,700 --> 00:22:51,500
+مثل الـ direct fluorescent antibody ال polymerase
+
+281
+00:22:51,500 --> 00:22:55,500
+chain reaction in PCR أو ال cell culture based
+
+282
+00:22:55,500 --> 00:22:59,940
+test يعني فحصات متمدة على إنه نم ال فيروس على cell
+
+283
+00:22:59,940 --> 00:23:07,220
+cultureو في عنا rapid tests بتاعه ال pregnancy
+
+284
+00:23:07,220 --> 00:23:11,960
+test ال cartridge تمام او ال hepatitis test او ال
+
+285
+00:23:11,960 --> 00:23:15,840
+aids test اللي استربيت هذه تمام؟ هذه الفحوصات اللي
+
+286
+00:23:15,840 --> 00:23:22,140
+هان متوفرة وبشكل يعني common في ال ..القطاع
+
+287
+00:23:22,140 --> 00:23:25,760
+التشخيصي لكن لو جينا ندورنا على القطاع الغزة
+
+288
+00:23:25,760 --> 00:23:30,260
+بنلاقي أنه يخلوا من هذه الفحوصات السبب كمان مرة هو
+
+289
+00:23:30,260 --> 00:23:34,280
+الاعتماد التام في التشخيص على اللي هو ال clinical
+
+290
+00:23:34,280 --> 00:23:39,040
+impression و أصلا يعني في مجتمع زي مجتمعنا ال
+
+291
+00:23:39,040 --> 00:23:43,240
+inflammation اعتبر مرض يستدعي الذهاب إلى الطبيب في
+
+292
+00:23:43,240 --> 00:23:46,180
+معظم الأحيان شعب صامد
+
+293
+00:23:49,420 --> 00:23:53,980
+أيضا مستوى ال antibody يمكن قياسه لماه من الدم
+
+294
+00:23:53,980 --> 00:23:57,800
+وينطبق عليه نفس القوة اللى كنا نقوله زمان إن
+
+295
+00:23:57,800 --> 00:24:02,140
+ارتفاع في ال titer طبعا الفحوصات اللى بنستخدمها
+
+296
+00:24:02,140 --> 00:24:05,060
+لقياس ال antibody في ال titer اللى هم ال hem
+
+297
+00:24:05,060 --> 00:24:07,880
+agglutination inhibition أو ال complement fixation
+
+298
+00:24:07,880 --> 00:24:13,140
+test كلا هما يستخدم لتقدير الأجسام المضادة في دم
+
+299
+00:24:13,140 --> 00:24:18,860
+المرضىهذه بعض الأمثلة بتورينا إنه كيف بناخد
+
+300
+00:24:18,860 --> 00:24:23,020
+نازوفرينجيا للسواب نعمله mixing بنحدد وقت زمان
+
+301
+00:24:23,020 --> 00:24:27,420
+معين بعدين بنحط ال strip فيه وبعد ال strip فترة
+
+302
+00:24:27,420 --> 00:24:30,980
+زمانية معينة بنقرأ إذا تكون خطوط بصت فإذا ما تكون
+
+303
+00:24:30,980 --> 00:24:36,200
+خطوط ملونة بيكون الفحص negative هذا فحص تاني flu
+
+304
+00:24:36,200 --> 00:24:37,360
+oya
+
+305
+00:24:39,580 --> 00:24:45,800
+وهذا كمان اللي هو Z-stat flu وبيعتمد على استخدام
+
+306
+00:24:45,800 --> 00:24:48,660
+اللي هو ال neuroaminidase، ال neuroaminidase
+
+307
+00:24:48,660 --> 00:24:52,980
+بتعرفين بيكسر جنة اللي هو السيالك أسد فبيحطوا
+
+308
+00:24:52,980 --> 00:24:56,940
+substrate، substrate، هذا ال substrate مرتبط ممين؟
+
+309
+00:24:56,940 --> 00:25:02,830
+بسيالك أسد analogالان لو في فيروس في المكان وحاطين
+
+310
+00:25:02,830 --> 00:25:06,950
+عليه ال substrate هذا هيفصل مين؟ هيفصل السيالك أسد
+
+311
+00:25:06,950 --> 00:25:10,770
+لأن ال neuro aminic acid هو سيالك أسد، هو سيالك
+
+312
+00:25:10,770 --> 00:25:13,630
+أسد، هيفصل ال chromogene اللي هو ال substrate
+
+313
+00:25:13,630 --> 00:25:18,530
+الملون عن السيالك
+
+314
+00:25:18,530 --> 00:25:22,550
+أسد وبتالي بيطلع عندنا لون مميز، هذا فحص فكرته
+
+315
+00:25:22,550 --> 00:25:26,710
+حلوة ومستخدم أيضا في diagnosis معتمد على مين كم
+
+316
+00:25:26,710 --> 00:25:28,850
+مرة؟ على neuroaminidase
+
+317
+00:25:30,690 --> 00:25:35,550
+التريتمنت للفيرال الانفلوانزا تتلخص في مجموعة من
+
+318
+00:25:35,550 --> 00:25:41,170
+العقاقير مثل الريمانتدين type A only وطبعا شفنا
+
+319
+00:25:41,170 --> 00:25:44,650
+انه فاشل هذا الريمانتدين والأمانتدين كان فاشل في
+
+320
+00:25:44,650 --> 00:25:49,190
+مين؟ في ال H5N1 لكن في الاخرين الفيروس الانفلوانزا
+
+321
+00:25:49,190 --> 00:25:53,590
+شغل type A وtype A الامانتدين زي المفير ممكن
+
+322
+00:25:53,590 --> 00:25:58,420
+يستخدموا فيهافي الـ type A و الـ type B لكن لحظة
+
+323
+00:25:58,420 --> 00:26:04,880
+لم يعتمد كإجراء ويقائي الذنبير لا يستخدم كإجراء
+
+324
+00:26:04,880 --> 00:26:09,540
+ويقائي بينما الأسر الذنبير بيستخدموا لإلاج و
+
+325
+00:26:09,540 --> 00:26:13,800
+بيستخدموا كمرة لمين؟ لـ prevention و بيستخدم الـ
+
+326
+00:26:13,800 --> 00:26:14,940
+type A و الـ type B
+
+327
+00:26:18,320 --> 00:26:22,060
+الـ Prevention للإنفلوانزا بشكل عام هنرجو انه عشان
+
+328
+00:26:22,060 --> 00:26:27,120
+احنا خلطنا بين انفلوانزا و ركزنا عمين على H5N1 انه
+
+329
+00:26:27,120 --> 00:26:31,480
+نحاول نفصل بينهم تمام؟ هم صحيح اتنين انفلوانزا لكن
+
+330
+00:26:31,480 --> 00:26:36,280
+واحد له special situation اللي هو الـH5N1 لأنه
+
+331
+00:26:36,280 --> 00:26:39,880
+بنالكه highly pathogenic فحاولنا نركز عليه شوية
+
+332
+00:26:39,880 --> 00:26:45,620
+طيب لو انسينا الـH5N1 الآن و نتكلم عن الانفلوانزا
+
+333
+00:26:45,620 --> 00:26:49,640
+بشكل عاممش احنا بنسمع ان في influenza vaccine ال
+
+334
+00:26:49,640 --> 00:26:54,140
+influenza vaccine طب ال influenza vaccine بيحتوي
+
+335
+00:26:54,140 --> 00:26:57,780
+على السلالات البشرية الشائعة اللي هم بتبقى على مين
+
+336
+00:26:57,780 --> 00:27:04,700
+H1 in one H3 in two isolates كمان مرة هم مش اتنين
+
+337
+00:27:04,700 --> 00:27:12,370
+هم سلالات بينتموا لهذه السلالتين يعني في صدلان
+
+338
+00:27:12,370 --> 00:27:18,570
+احنا بقول لكوا بس they undergo antigenic drift،
+
+339
+00:27:18,570 --> 00:27:23,990
+فال vaccine each year is updated، كل سنة بيصيرله
+
+340
+00:27:23,990 --> 00:27:27,730
+updating، ايش يعني updating؟ ايش صار السنة الماضية
+
+341
+00:27:27,730 --> 00:27:32,510
+سلالات جديدة بنجمعها و بنحطها في هذا اللي هو ال
+
+342
+00:27:32,510 --> 00:27:37,680
+vaccine؟طبعا الجمهورية الرقم تلاتة ال vaccine is
+
+343
+00:27:37,680 --> 00:27:44,300
+usually reformulated يعني عاد تشكيله each year to
+
+344
+00:27:44,300 --> 00:27:47,380
+contain the current antigenic strains both killed
+
+345
+00:27:47,380 --> 00:27:51,180
+and live vaccines contain two A strains and one B
+
+346
+00:27:51,180 --> 00:27:55,510
+strain of influenza virusThere are two types of
+
+347
+00:27:55,510 --> 00:27:57,670
+influenza vaccine available في الولايات المتحدة
+
+348
+00:27:57,670 --> 00:28:02,610
+الأول killed vaccine وبيحتوي على ال purified
+
+349
+00:28:02,610 --> 00:28:08,780
+subunits من الفيروسالهيم أجلوتنين والهيم أجلوتنين
+
+350
+00:28:08,780 --> 00:28:15,620
+والهيم
+
+351
+00:28:15,620 --> 00:28:25,360
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+352
+00:28:25,360 --> 00:28:26,380
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+353
+00:28:26,380 --> 00:28:26,720
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+354
+00:28:26,720 --> 00:28:26,720
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+355
+00:28:26,720 --> 00:28:26,720
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+356
+00:28:26,720 --> 00:28:26,720
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+357
+00:28:26,720 --> 00:28:27,080
+أجلوتنين الهيم أجلوتنين الهيم أجلوتنين الهيم
+
+358
+00:28:27,080 --> 00:28:33,840
+أجلوتنين الهيم
+
+359
+00:28:33,840 --> 00:28:36,510
+أجلوتنبيحضروه من خلال inactivation with
+
+360
+00:28:36,510 --> 00:28:40,270
+formaldehyde وعلى فكرة ال formaldehyde استخدمناها
+
+361
+00:28:40,270 --> 00:28:43,330
+أيضا حتى في ال bacterial vaccine فإذا ال
+
+362
+00:28:43,330 --> 00:28:47,850
+formaldehyde مشهور في كل من ال viral و ال
+
+363
+00:28:47,850 --> 00:28:51,410
+bacterial vaccine بعد ال formaldehyde بيستخدموا ال
+
+364
+00:28:51,410 --> 00:28:55,790
+lipid solvent حتى يكسر ال virus و بعدين ناخد منه
+
+365
+00:28:55,790 --> 00:29:00,430
+ال neuroamidase و ال hemeإذا ال prevention في ال
+
+366
+00:29:00,430 --> 00:29:04,650
+influenza لحد الآن معتمد بالدرجة الأولى على مين؟
+
+367
+00:29:04,650 --> 00:29:09,470
+على ال vaccine اللي فيه منه كمان مرة صينفين طب فيه
+
+368
+00:29:09,470 --> 00:29:16,530
+صينف تالت منه؟ درسنا conditional
+
+369
+00:29:16,530 --> 00:29:23,050
+lethal mutation إيش معنى الفيروس هادا؟هذا اللي
+
+370
+00:29:23,050 --> 00:29:26,270
+قلنا عنه بيتكاثر في الأنف و في ال upper
+
+371
+00:29:26,270 --> 00:29:29,570
+respiratory لإن هو نزل لتحت مابقدرش يتكاثر لإن هو
+
+372
+00:29:29,570 --> 00:29:33,470
+temperature sensitive mutant و كذلك يستخدمونه ك
+
+373
+00:29:33,470 --> 00:29:40,650
+spray ك nasal spray طبعا
+
+374
+00:29:40,650 --> 00:29:47,410
+إذا فاكرين قلنا إنه قد نستخدم بعض العقاقير مش فقط
+
+375
+00:29:47,410 --> 00:29:51,840
+لل treatmentأيضًا لمن؟ لـ Prevention مثل
+
+376
+00:29:51,840 --> 00:29:55,260
+الأمانتدين والريمانتدين والأصول تمافير، بينما
+
+377
+00:29:55,260 --> 00:29:59,320
+الـXanamavir جونالكول لم يعتمد لـ Prevention مين
+
+378
+00:29:59,320 --> 00:30:01,780
+اللي ممكن ياخد الفاكسين؟ غالبًا الـ elderly
+
+379
+00:30:01,780 --> 00:30:05,880
+people، الناس اللي فوق الخمسة أو ستين سنة
+
+380
+00:30:08,930 --> 00:30:12,230
+طبعا الأفعال هذه ولا بأي حالة من الأحوال ممكن
+
+381
+00:30:12,230 --> 00:30:16,070
+نستخدمها كبديل عن ال vaccine وما زالت ال
+
+382
+00:30:16,070 --> 00:30:22,370
+immunization هي الطريقة الأكثر يعني فعالية في منع
+
+383
+00:30:22,370 --> 00:30:27,750
+ال diseaseالفيروس التاني اللي هو ال Paramyoxic
+
+384
+00:30:27,750 --> 00:30:30,570
+virus اللي هو مجموعة من الفيروسات طبعا ال
+
+385
+00:30:30,570 --> 00:30:33,990
+orthomyoxic virus أخدنا الممثل عنه الوحيد منه اللي
+
+386
+00:30:33,990 --> 00:30:39,450
+هو ال influenza virus لكن هنا سنتحدث عن مجموعة من
+
+387
+00:30:39,450 --> 00:30:45,110
+الفيروسات تحت عنوان Paramyoxic virus اتلقونا على
+
+388
+00:30:45,110 --> 00:30:51,350
+ال spike هذا بقولنا HN HN يعني بتحتوي على
+
+389
+00:30:52,650 --> 00:30:57,590
+Hemagglutinin و Neuraminidase at the same spike
+
+390
+00:30:57,590 --> 00:31:02,430
+هذا الكلام مار معانا لما عملنا مقارنة بين ال Ortho
+
+391
+00:31:02,430 --> 00:31:08,110
+و Paramyoxivirus طبعا ال M-protein زي ال M-protein
+
+392
+00:31:08,110 --> 00:31:14,310
+اللي هناك اللي هي ال matrix protein طيب هذه
+
+393
+00:31:14,310 --> 00:31:17,410
+المجموعة بالنسبة لنا كانت في يوم من الأيام من
+
+394
+00:31:17,410 --> 00:31:22,440
+المجموعات الخطيرة جدا لانها بتشملقائمة من
+
+395
+00:31:22,440 --> 00:31:26,140
+الفيروسات اللي كانت تسبب أمراض الإنسان قاتلة لو لا
+
+396
+00:31:26,140 --> 00:31:32,360
+وجود ال vaccination لحتفرت بأهميتها بشكل كبير في
+
+397
+00:31:32,360 --> 00:31:37,420
+عالم ال micro biologyIt is composed of one piece
+
+398
+00:31:37,420 --> 00:31:41,620
+of a single stranded RNA, a helical nucleocapsid
+
+399
+00:31:41,620 --> 00:31:45,080
+and outer lipoprotein وبيقول عنها .. بيقول عنها
+
+400
+00:31:45,080 --> 00:31:51,120
+الجينوم تبعها typical of paramoxivirus يعني كلهم
+
+401
+00:31:51,120 --> 00:31:57,980
+الجينوم تبعهم متشابه Negative polarity جينوم موجود
+
+402
+00:31:57,980 --> 00:32:01,600
+معاه RNA dependent RNA polymerase عشان يقدر يحوله
+
+403
+00:32:01,600 --> 00:32:05,860
+من negative sense إلى positive senseوالجينوم بيقول
+
+404
+00:32:05,860 --> 00:32:10,680
+عنه انه ليس infectious السبب انه .. انه مضطر يجيب
+
+405
+00:32:10,680 --> 00:32:14,000
+معاه إشي يبتدى مش infectious الحق ال envelope is
+
+406
+00:32:14,000 --> 00:32:17,000
+covered with spikes which contain hemagglutinin,
+
+407
+00:32:17,360 --> 00:32:20,160
+neuroamylidase او a fusion protein لاحظوا الآن انا
+
+408
+00:32:20,160 --> 00:32:25,900
+بتكلم بعمومية انا الآن بتكلم بالعموم ال spikes اما
+
+409
+00:32:25,900 --> 00:32:28,540
+بتحتوى على hemagglutinin و neuroamylidase او
+
+410
+00:32:28,540 --> 00:32:31,820
+fusion protein هذه ماكانتش موجودة في من؟ في ال
+
+411
+00:32:31,820 --> 00:32:38,200
+orthopoxy virusesوفي بعض الحالات الهيمولاسيس ليس
+
+412
+00:32:38,200 --> 00:32:41,480
+فقط تعمل ال fusion تعمل أيضا الهيمولاسيس لذلك يوجد
+
+413
+00:32:41,480 --> 00:32:44,700
+فيه نيرو امينوديز يوجد فيه مأجلوتنين يوجد فيه فسيل
+
+414
+00:32:44,700 --> 00:32:48,480
+فيوجن يوجد فيه الهيمولاسيس يوجد فيه الـ spike سبعت
+
+415
+00:32:48,480 --> 00:32:59,300
+ال Paramyxivirus بنجسمها إلى تلت مجموعات ال ال ال
+
+416
+00:32:59,300 --> 00:33:00,080
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+417
+00:33:00,080 --> 00:33:00,880
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+418
+00:33:00,880 --> 00:33:01,440
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+419
+00:33:01,440 --> 00:33:03,760
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+420
+00:33:03,760 --> 00:33:03,760
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+421
+00:33:03,760 --> 00:33:03,780
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+422
+00:33:05,580 --> 00:33:10,940
+في حجم مربيلي فيروس ضمن الـ Paramyx Verdi بيضم
+
+423
+00:33:10,940 --> 00:33:15,240
+اللي هو ال missiles أو الربيولا والنيومو فيروس
+
+424
+00:33:15,240 --> 00:33:19,520
+بيضم فيروس اسمه Respiratory syncytial virus إذن ال
+
+425
+00:33:19,520 --> 00:33:25,560
+Paramyx Verdi تشمل تلت sub families اللي هم
+
+426
+00:33:25,560 --> 00:33:30,640
+Paramyx Virus مربيلي فيروس ونيومو فيروس الأسماء
+
+427
+00:33:30,640 --> 00:33:35,470
+اللي قدامكواPrespiratory-sensitive virus, Measles,
+
+428
+00:33:35,890 --> 00:33:41,750
+Mumps, and Parainfluenza virus دعونا نطلع على
+
+429
+00:33:41,750 --> 00:33:48,290
+الفروقات في الـ spikes سبعتهم الميسل
+
+430
+00:33:48,290 --> 00:33:53,370
+فيروس عنده هيم أجليتينين بس ماعندوش نيورو أمينيديز
+
+431
+00:33:53,370 --> 00:33:57,750
+خدينا بس العمودين الأولانية و بعدين نشوف اللي هو
+
+432
+00:33:57,750 --> 00:34:02,920
+العمود التالتالـ Mumps عنده Hemagglutinin و عنده
+
+433
+00:34:02,920 --> 00:34:07,380
+Neuroaminidase الـ Respiratory لا عنده
+
+434
+00:34:07,380 --> 00:34:10,920
+Hemagglutinin ولا عنده Neuroaminidase الـ
+
+435
+00:34:10,920 --> 00:34:16,520
+Parainfluenza زي الـ Mumps فيروس تحتوي على كل من
+
+436
+00:34:16,520 --> 00:34:20,280
+ال Hemagglutinin و Neuroaminidase لكن لاحظوا ال
+
+437
+00:34:20,280 --> 00:34:24,040
+fusion proteinكلهم بيحتوى على fusion ال protein
+
+438
+00:34:24,040 --> 00:34:31,400
+يعني كلهم بيعملوا syncytia بيعملوا ال giant cell
+
+439
+00:34:31,400 --> 00:34:35,940
+اللي في ال cell culture طيب
+
+440
+00:34:35,940 --> 00:34:41,340
+نبدأ بمين؟ بال measles هل تعلموا ان ال measles كان
+
+441
+00:34:41,340 --> 00:34:48,670
+الناس يخافوا منها خوفهم من الطعون؟لأنه يمكن نصف
+
+442
+00:34:48,670 --> 00:34:52,950
+أطفال المنطقة اللي كانت تصاب بال missiles كانوا
+
+443
+00:34:52,950 --> 00:34:58,580
+برضه يموتوافالميسلز من الأمراض الخطيرة جدا و التي
+
+444
+00:34:58,580 --> 00:35:03,720
+أدت إلى يعني خلّيني نقول قتل ملايين من البشر في
+
+445
+00:35:03,720 --> 00:35:08,080
+عصور صادقة بفضل من الله سبحانه وتعالى و بفضل ال
+
+446
+00:35:08,080 --> 00:35:11,240
+vaccine ثم بفضل ال vaccine تم تقريبا القضاء على
+
+447
+00:35:11,240 --> 00:35:15,660
+هذا المرض و أصبح هذه الحالات نادر جدا و إذا كان في
+
+448
+00:35:15,660 --> 00:35:18,940
+حالات غالبا بتكون mild cases لأن ال vaccine بيكون
+
+449
+00:35:18,940 --> 00:35:22,290
+عاملprotection للإنسان إذن ال missiles virus أو
+
+450
+00:35:22,290 --> 00:35:25,730
+الحصبة وبيتبيزوا بين الحصبة و الحصبة الألمانية
+
+451
+00:35:25,730 --> 00:35:28,490
+الحصبة الألمانية اللي هي الربلة برضه واحد من نفس
+
+452
+00:35:28,490 --> 00:35:33,730
+اللي هو العيلة ال missiles أخطر من الربلة ال
+
+453
+00:35:33,730 --> 00:35:37,050
+missiles مثلا في الأم الحامل كانت تؤدي إلى وفاة
+
+454
+00:35:37,050 --> 00:35:41,150
+الجنين لكن الربلة كانت تؤدي إلى تشوهات في الجنين
+
+455
+00:35:41,150 --> 00:35:46,130
+يعني شوفوا كده شدة المرض في ال missiles أعلى بكثير
+
+456
+00:35:46,130 --> 00:35:49,050
+من اللي هو ال .. ال .. ال ..
+
+457
+00:35:52,230 --> 00:35:56,430
+الفيروس يسبب فيه ميسيلات، مخلوق مسموح بـ
+
+458
+00:35:56,430 --> 00:36:00,910
+maculopapular rash، أهم يميزه طفاح جلدي، يحدث
+
+459
+00:36:00,910 --> 00:36:08,070
+أولاً في الطفولة، الخواص العام له الـRNA و
+
+460
+00:36:08,070 --> 00:36:11,450
+الـNucleocapsid ميسيلات، فيروس أرضوس و بطبيكال
+
+461
+00:36:11,450 --> 00:36:12,470
+باراميكسفيروس
+
+462
+00:36:17,410 --> 00:36:20,970
+الـ single-stranded RNA، negative single-stranded
+
+463
+00:36:20,970 --> 00:36:24,230
+RNA، وفيها الـ RNA dependent RNA Polymerase، هاي
+
+464
+00:36:24,230 --> 00:36:27,970
+اللي هم الـ الـ ال typical genome أو الـ virus
+
+465
+00:36:30,050 --> 00:36:37,030
+البيعس لديه اتفاقنات اتفاقنية اتفاقنية
+
+466
+00:36:37,030 --> 00:36:41,630
+اتفاقنية
+
+467
+00:36:41,630 --> 00:36:45,330
+اتفاقنية اتفاقنية اتفاقنية اتفاقنية اتفاقنية
+
+468
+00:36:45,330 --> 00:36:47,710
+اتفاقنية اتفاقنية اتفاقنية اتفاقنية اتفاقنية
+
+469
+00:36:47,710 --> 00:36:54,890
+اتفاقنية اتفاقنية اتفاقنيةنتلقى النبع هذا ببلغ
+
+470
+00:36:54,890 --> 00:36:58,290
+الارتياح ودلها single serotype يعني الفاكسين أحد
+
+471
+00:36:58,290 --> 00:37:01,310
+أسرار نجاح الفاكسين أنه single serotype
+
+472
+00:37:03,650 --> 00:37:07,150
+and hemeagglutinin is the antigen against which
+
+473
+00:37:07,150 --> 00:37:11,250
+neutralizing antibody is directed نفس الكلام اللي
+
+474
+00:37:11,250 --> 00:37:14,670
+حكيناه لمين؟ للإنفلوانزا إنه إذا الجسم مكوّن
+
+475
+00:37:14,670 --> 00:37:18,030
+antibody للهيم أجلوتينين فبيعمل neutralization
+
+476
+00:37:18,030 --> 00:37:21,490
+ليش؟ لأنه الهيم أجلوتينين هو المسؤول عن الإرتباب
+
+477
+00:37:21,490 --> 00:37:25,790
+بالcell surface والاختراق لداخل الخلية فإذا أنا
+
+478
+00:37:25,790 --> 00:37:29,450
+كونت antibody ضده أنا عملت له neutralization منعته
+
+479
+00:37:29,450 --> 00:37:34,410
+من الدخول إلى داخل الخليةhuman are the only
+
+480
+00:37:34,410 --> 00:37:38,070
+natural host for this virus هذا كمان سر من أسرار
+
+481
+00:37:38,070 --> 00:37:40,850
+نجاح من ال vaccine و ال prevention المرة الجاية ان
+
+482
+00:37:40,850 --> 00:37:42,730
+شاء الله نكمل عن هذا ال virus
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEUFxaEvUo4_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEUFxaEvUo4_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ddf13ef20f924ff245d006ffd8cf26780bec6099
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/BEUFxaEvUo4_postprocess.srt
@@ -0,0 +1,2156 @@
+1
+00:00:21,040 --> 00:00:23,460
+بسم الله الرحمن الرحيم احنا اليوم هبدأ ان شاء الله
+
+2
+00:00:23,460 --> 00:00:27,380
+بالفيروس رقم أربعة اللي هو cytomegalovirus و
+
+3
+00:00:27,380 --> 00:00:31,760
+cytomegalovirus بتميز يعني ارتباط وثيق بينه و بين
+
+4
+00:00:31,760 --> 00:00:36,480
+ال congenital abnormalities في ال neonates و عندما
+
+5
+00:00:36,480 --> 00:00:38,780
+تحدثنا عن ال classification of medically important
+
+6
+00:00:38,780 --> 00:00:42,440
+viruses و اتكلمنا عن طرق الانتقال هذا الفيروس احتل
+
+7
+00:00:42,440 --> 00:00:47,420
+مكانة خاصة كنا بنتقل vertically من ال M إلى الجنين
+
+8
+00:00:48,060 --> 00:00:53,200
+ومن قناة الولادة وبين ال breast feeding يعني ثلاث
+
+9
+00:00:53,200 --> 00:00:56,440
+نقاط ولو بكبر ممكن ينتقل عن طريق برضه sexual
+
+10
+00:00:56,440 --> 00:00:58,760
+transmission وممكن ينتقل عن طريق ال bad
+
+11
+00:00:58,760 --> 00:01:03,800
+transfusion وينتقل عبر ال organ donation يعني تبرر
+
+12
+00:01:03,800 --> 00:01:09,740
+بكلية إلى أخر إذا فيروس مشهور بال congenital
+
+13
+00:01:09,740 --> 00:01:13,280
+abnormality بل هو رقم واحد مسبب لل congenital
+
+14
+00:01:13,280 --> 00:01:18,540
+abnormality في الولايات المتحدةقد يسبب نيمونيا و
+
+15
+00:01:18,540 --> 00:01:20,720
+اشياء اخرى في مصادر مصادر مصادر مصادر مصادر مصادر
+
+16
+00:01:20,720 --> 00:01:21,820
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+17
+00:01:21,820 --> 00:01:24,980
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+18
+00:01:24,980 --> 00:01:25,880
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+19
+00:01:25,880 --> 00:01:26,140
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+20
+00:01:26,140 --> 00:01:28,040
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+21
+00:01:28,040 --> 00:01:34,150
+مصادر مصادر مصادر مصادر مصادر مصالـ Mononucleosis
+
+22
+00:01:34,150 --> 00:01:38,750
+اسم مش مرتبط بالـ cytone gallovirus مرتبط بالفيروس
+
+23
+00:01:38,750 --> 00:01:42,430
+اللي بعديلهو الـ Epstein Bar Virus عشان نميز بين
+
+24
+00:01:42,430 --> 00:01:46,970
+اتنين بدنا نقول واحد heterofile negative و
+
+25
+00:01:46,970 --> 00:01:49,970
+heterofile positive مين ال heterofile
+
+26
+00:01:49,970 --> 00:01:54,070
+mononucleosis negative ال CMV و ال Epstein Bar
+
+27
+00:01:54,070 --> 00:01:58,510
+Virus هو ال heterofile mononucleosis positive ايش
+
+28
+00:01:58,510 --> 00:02:01,610
+يعني heterofile أساسا؟Heterophyll معناها فنة
+
+29
+00:02:01,610 --> 00:02:06,850
+antibody، antibody، إله خاصية معينة، أحنا الأصل
+
+30
+00:02:06,850 --> 00:02:11,670
+بنكشف عن ال antibody باستخدام نفس ال antigen اللي
+
+31
+00:02:11,670 --> 00:02:16,800
+سبب إنتاج هذا ال antibody، ولا مش هيك؟ هيكالـ
+
+32
+00:02:16,800 --> 00:02:21,120
+Heterophil Antibody هو Antibody تم توظيف أنتجين
+
+33
+00:02:21,120 --> 00:02:26,440
+غير الـ Antigen اللي تم أو أسبب إنتاجه في الكشف عن
+
+34
+00:02:26,440 --> 00:02:29,960
+هذا الـ Antibody إذن هو Non-specific أصلا Non
+
+35
+00:02:29,960 --> 00:02:35,260
+-specific إذن من تعريفه هو Non-specific اتفقنا
+
+36
+00:02:35,260 --> 00:02:38,560
+Congenital Abnormalities بعض الأحيان pneumonia and
+
+37
+00:02:38,560 --> 00:02:41,360
+other diseases in immunocompromised ممكن نسميه
+
+38
+00:02:41,360 --> 00:02:44,160
+كمان Heterophil Negative قولنا Infectious
+
+39
+00:02:44,160 --> 00:02:47,610
+Mononucleosisin immunocompetent يعني الناس عندهم
+
+40
+00:02:47,610 --> 00:02:55,050
+مناعة جيدة من الخصائص المهمة ان احنا لحد الآن لم
+
+41
+00:02:55,050 --> 00:02:57,990
+نجد اي فرق بين herpes similics type 1 ولا type 2
+
+42
+00:02:57,990 --> 00:03:02,410
+ولا varicella ولا أيضا من اللي هو cytomegalovirus
+
+43
+00:03:02,410 --> 00:03:06,210
+في الشكل والتركيب يشبه بعض إلى حد كبير لكن
+
+44
+00:03:06,210 --> 00:03:10,270
+antigenically it is different single serotype
+
+45
+00:03:12,290 --> 00:03:15,470
+الإنسان هو ال natural host فيه CMV بتصيب الحيوانات
+
+46
+00:03:15,470 --> 00:03:19,830
+لكن مابتصيبش اللي هو بتنتقلش لها الإنسان الاسم
+
+47
+00:03:19,830 --> 00:03:25,770
+أُخذ من cytomegalovirus أُخذ من الشكل اللي بيحدث
+
+48
+00:03:25,770 --> 00:03:29,190
+في الخلايا عندما ينمو عليها وهي تضخيم الخلايا أو
+
+49
+00:03:29,190 --> 00:03:33,750
+تكبير الخلايا cytomegalo megalo يعني كبير cyt يعني
+
+50
+00:03:33,750 --> 00:03:37,110
+خلوي إذن هو الفيروس المضخم للخلايا
+
+51
+00:03:39,800 --> 00:03:43,740
+ينتقل كما ذكرت في المقدمة عبر يعني طرق مختلفة زي
+
+52
+00:03:43,740 --> 00:03:47,280
+ما ذكرنا early in life في المحل الجنينية birth
+
+53
+00:03:47,280 --> 00:03:51,980
+canal و ال breast milk في ال children ممكن يعني
+
+54
+00:03:51,980 --> 00:03:57,080
+ينتقل عبر ال saliva في ال adults sexually و during
+
+55
+00:03:57,080 --> 00:04:01,680
+blood transfusion and organ transplants طلعوا الآن
+
+56
+00:04:01,680 --> 00:04:05,040
+الرقم اللي بدنا نذكره عن نسبة الإصابة في ال adults
+
+57
+00:04:05,040 --> 00:04:07,740
+في العالم أو في الولايات المتحدة بالأخرىتمانين
+
+58
+00:04:07,740 --> 00:04:11,520
+بالمائة من ال adults have antibody against this
+
+59
+00:04:11,520 --> 00:04:19,180
+virus تمانين بالمائة when occurs worldwide معناه
+
+60
+00:04:19,180 --> 00:04:22,560
+يحكي انه كمان مش بس في دولة المتحدة في العالم كله
+
+61
+00:04:22,560 --> 00:04:27,080
+هذا ال virus منتشر بشكل كبير جدا تمانين بالمائة من
+
+62
+00:04:27,080 --> 00:04:31,620
+السكانعزيزي انا الوحيد في انه صحيح هم قشر بشكل
+
+63
+00:04:31,620 --> 00:04:38,220
+كبير لكن الناس اللي بتأثر منه هم قلة لكن هذه القلة
+
+64
+00:04:38,220 --> 00:04:42,300
+للأسف ايضا تعاني بشكل كبير لما اتكلم عن mental
+
+65
+00:04:42,300 --> 00:04:46,920
+retardation اتأخر عقلي او ذهني لما اتكلم عن
+
+66
+00:04:46,920 --> 00:04:51,260
+abnormal organ development في الأطفال microcephaly
+
+67
+00:04:51,260 --> 00:04:55,860
+رأس صغيرة امراض خطيرة جدا ممكن تنتج عن هذا ال
+
+68
+00:04:55,860 --> 00:04:56,140
+disease
+
+69
+00:05:00,580 --> 00:05:04,900
+فيها يسموها cytomegalic inclusion disease، سنتكلم
+
+70
+00:05:04,900 --> 00:05:10,820
+عنها كمان شوية، لكن هذا الفيروس هو اللي تميز بالـ
+
+71
+00:05:10,820 --> 00:05:13,360
+Intranuclear Inclusion اللي يقولون عنها Owls Eye،
+
+72
+00:05:13,360 --> 00:05:14,040
+فاكرينها؟
+
+73
+00:05:18,360 --> 00:05:24,180
+في حاجة مهمة انه في المرحلة الجنينية لو كانت الأم
+
+74
+00:05:24,180 --> 00:05:29,200
+مصابة في بداية الحمل هذا هيكون اخطر بكثير مما لو
+
+75
+00:05:29,200 --> 00:05:33,240
+كانت مصابة او اصيبت بعد مين بعد ال second او ال
+
+76
+00:05:33,240 --> 00:05:37,460
+third trimester لان في ال first trimester بيكون ال
+
+77
+00:05:37,460 --> 00:05:42,760
+fetal او الخلايا الجنينية بتنقسم بسرعة جنونية ايضا
+
+78
+00:05:42,760 --> 00:05:46,300
+تمام؟وبالتالي سهل على الفيروس انه يعمل
+
+79
+00:05:46,300 --> 00:05:49,720
+multiplication فيها وبالتالي يؤثر على ال
+
+80
+00:05:49,720 --> 00:05:54,560
+development of organs، إذا التأثر بيكون أكبر كل ما
+
+81
+00:05:54,560 --> 00:05:59,120
+كان الحمل لسه أبكر تمام؟ وبيقل التأثير كل ما زاد
+
+82
+00:05:59,120 --> 00:06:04,800
+اللي هو فترة الحملغالبا لو الأم عندها أجسام مضادة
+
+83
+00:06:04,800 --> 00:06:09,560
+ضد هذا الفيروس، الطفل لا يصاب، الطفل لا يصاب، إذن
+
+84
+00:06:09,560 --> 00:06:13,880
+هي المشكلة المهم فقط في النساء اللواتي يصابن
+
+85
+00:06:13,880 --> 00:06:19,540
+بالفيروس لأول مرة خلال فترة الحمل، وبالتالي بيكون
+
+86
+00:06:19,540 --> 00:06:22,940
+الفيروس أصاب الأم وأصاب أيضا اللي هو الجنة
+
+87
+00:06:28,830 --> 00:06:31,810
+معظم الإصابات تبدأ في ال early childhood و بتكون
+
+88
+00:06:31,810 --> 00:06:35,850
+asymptomatic يعني بدون أي أعراب except in
+
+89
+00:06:35,850 --> 00:06:40,070
+immunocompromised individuals ممكن تعمل لتنسي في
+
+90
+00:06:40,070 --> 00:06:44,070
+ال eucocytes في قوية الدم البيضاء لتنسي انتوا
+
+91
+00:06:44,070 --> 00:06:49,650
+عارفين لتنسي صرفها من صفات ال herpes virusesand
+
+92
+00:06:49,650 --> 00:06:53,130
+can be reactivated when cell-mediated immunity is
+
+93
+00:06:53,130 --> 00:06:56,550
+decreased ما اتغير ايش عن الكلام اللي حاكينها
+
+94
+00:06:56,550 --> 00:07:01,170
+للفيروس رقم 1 و 2 و 3 في هذا الموضوع هنا النقطة
+
+95
+00:07:01,170 --> 00:07:06,790
+المهمة CMV can persist for long periods when in
+
+96
+00:07:06,790 --> 00:07:12,330
+kidneys لذلك في نقل الأعضاء الآن أصبح لزمن لزمن
+
+97
+00:07:12,330 --> 00:07:15,930
+على أن نفحص الكلية المراد نقلها اللي هي ال donor
+
+98
+00:07:15,930 --> 00:07:20,610
+يعني تمام لل CMVفي .. في أحد ال recommendation
+
+99
+00:07:20,610 --> 00:07:27,790
+بتقول انه ماننقلش كيلية إلا من مريض خالي من مين؟
+
+100
+00:07:27,790 --> 00:07:32,570
+من ال CMV إلا من دون العفوان خالي من ال CMV if
+
+101
+00:07:32,570 --> 00:07:36,550
+possible ايش يعني if possible؟ إذا كان الأمر ممكن
+
+102
+00:07:36,550 --> 00:07:42,390
+انت بتعرف نتابع فقه الموازنات فقه الموازنات في
+
+103
+00:07:42,390 --> 00:07:48,440
+الطب مثلا بنقول ان ممكن نبص إيدفي سبيل 800 ميه
+
+104
+00:07:48,440 --> 00:07:52,120
+بيهب إيده تنجرس؟ ماحدش، ضرر، ضرر كبير، لكن أنه
+
+105
+00:07:52,120 --> 00:07:56,720
+أكبر ضرر؟ انجص الراحت اليد ولا كل اليد؟ مثلا، من
+
+106
+00:07:56,720 --> 00:08:01,960
+الراحت اليد، انجص الإيد ولا يموت المريض؟ لأ، منجص
+
+107
+00:08:01,960 --> 00:08:05,740
+الإيد، فإذا احنا بنعمل مفاضلة بين ضررين، تمام؟ أخف
+
+108
+00:08:05,740 --> 00:08:09,190
+الضررين، وهذا بيسمي فقه الموازناتفي الإسلام موجود
+
+109
+00:08:09,190 --> 00:08:12,150
+وفي الطب واللي هو طبعا الإسلام ما نهاش حياة
+
+110
+00:08:12,150 --> 00:08:16,750
+وبالتالي في كل منح الحياة يبقى أن يستخدم هذا الفقه
+
+111
+00:08:16,750 --> 00:08:21,870
+أو الفقه الموازنةوبالتالي بنقول ان بعض الأحيان نقل
+
+112
+00:08:21,870 --> 00:08:26,410
+كيليا ب CMV يعني الموجود فيها CMV أقل دولة من عدد
+
+113
+00:08:26,410 --> 00:08:30,430
+نقل الكيليا وموت المريض اللي بنتظر هذه الكيليا اذا
+
+114
+00:08:30,430 --> 00:08:34,270
+احنا بننصح بنقول if possible اذا كان في خيار انه
+
+115
+00:08:34,270 --> 00:08:38,590
+نجله كيليا بدون CMV بيكون جيد اذا مافيش هذا الخيار
+
+116
+00:08:38,590 --> 00:08:43,810
+للأسف مضطرين نجله طبعا الخشية وين الخشية ال CMV
+
+117
+00:08:43,810 --> 00:08:46,930
+معظم الحاجات بيقولون انها symptomatic لكن مريض نقل
+
+118
+00:08:46,930 --> 00:08:50,300
+الأعضاءغالبا احنا .. مش غالبا، احنا هنعطيه اصلا
+
+119
+00:08:50,300 --> 00:08:52,620
+immunosuppressive agent، ال immunosuppressive
+
+120
+00:08:52,620 --> 00:08:56,440
+agents هذه بتخفض جهاز المناع وبالتالي هو باعتباره
+
+121
+00:08:56,440 --> 00:09:00,320
+immunocompromised فال CMV ممكن يعمل complication
+
+122
+00:09:00,320 --> 00:09:06,310
+عندها المريضأحنا شوفنا إن الـ Herpes Simplex Type
+
+123
+00:09:06,310 --> 00:09:11,070
+I و Type II عملوا Evasion للـimmune system يعني
+
+124
+00:09:11,070 --> 00:09:17,030
+اختفوا داخل الخلايا دون ظهور علامات على الخلية
+
+125
+00:09:17,030 --> 00:09:21,290
+تشير إلى أن الخلية مصابة بالفيروس هل الـCMV بيمتلك
+
+126
+00:09:21,290 --> 00:09:26,190
+هذه المهارة؟ بيمتلك مهارة يمكن مميزة أكتر من
+
+127
+00:09:26,190 --> 00:09:29,930
+Herpes Simplex Type I و Type II إيش بيعمل هذا؟
+
+128
+00:09:31,130 --> 00:09:34,470
+انتوا بتاعتوا اقولكوا class one MFC اللي هو ال
+
+129
+00:09:34,470 --> 00:09:38,470
+major host of compatibility class one هذا ال class
+
+130
+00:09:38,470 --> 00:09:43,890
+هو اللي بيحمل معاه ال antigen تبع الفيروس و بيعمله
+
+131
+00:09:43,890 --> 00:09:47,130
+presentation على ال surface تمام؟ يبقى لازم يكون
+
+132
+00:09:47,130 --> 00:09:50,190
+في طابة class one مع مين؟ مع ال viral antigen
+
+133
+00:09:51,570 --> 00:09:57,130
+الـCNV من ذكائه عن الانتجن أو انتجناته ما بترتبطش
+
+134
+00:09:57,130 --> 00:10:01,570
+بثبات مع class one كل ما بيرتبط بينفك كل ما بيرتبط
+
+135
+00:10:01,570 --> 00:10:05,090
+بينفك فبالتالي هذا بيضطر يصعد لحاله على الخلايا
+
+136
+00:10:05,090 --> 00:10:08,290
+لما يصعد لحاله على الخلايا ايش معاناها؟ ان الخلية
+
+137
+00:10:08,290 --> 00:10:12,010
+مالها normal cell normal cell يعني الـcytoxic T
+
+138
+00:10:12,010 --> 00:10:16,410
+cellمش هتقدر تتعرف على إيه بقى عنده قدرة على اللي
+
+139
+00:10:16,410 --> 00:10:20,310
+تنسي وخداع دي هذا المناعة بهذه القالية إيش القالية
+
+140
+00:10:20,310 --> 00:10:24,750
+كمان مرة؟ عدم تكوين stable bonding بين الانتجين
+
+141
+00:10:24,750 --> 00:10:34,750
+وبين ال class I MHC نفس
+
+142
+00:10:34,750 --> 00:10:41,950
+ال disease بيعمل immunosuppression يعني المصاببالـ
+
+143
+00:10:41,950 --> 00:10:47,170
+cytomegalovirus مانعته مالها هتنخفض يعني حتى لو
+
+144
+00:10:47,170 --> 00:10:51,350
+كان هو immunocompetent مانعته هتنخفض ايه السبب؟ ان
+
+145
+00:10:51,350 --> 00:10:54,670
+هو بيعمل infection او بيعمل effect by inhibiting T
+
+146
+00:10:54,670 --> 00:11:00,550
+cells هو عنده مقدرة على انه ينزل من كفاءة ال T
+
+147
+00:11:00,550 --> 00:11:04,690
+cell اذا نزل من كفاءة ال T cell هو نزل من كفاءة ال
+
+148
+00:11:04,690 --> 00:11:08,650
+cell mediated immunity و ال humoral immunity ايضا
+
+149
+00:11:09,450 --> 00:11:12,510
+هواتف محافظة ضد الـCMV تحتوي على الـCirculating
+
+150
+00:11:12,510 --> 00:11:16,790
+Antibody وCell-Mediated Immunity كيف يرد جهاز منع
+
+151
+00:11:16,790 --> 00:11:21,090
+تبعنا من شغلتين بالانتبادي و بالcell-mediated
+
+152
+00:11:21,090 --> 00:11:27,310
+immunity لكن يا هل ترى مين الأهم فيهم الانتبادي
+
+153
+00:11:27,310 --> 00:11:30,910
+response ولا ال cell-mediated response؟ أكيد ال
+
+154
+00:11:30,910 --> 00:11:34,370
+cell-mediated response عارفين كيف عرفنا؟ Cellular
+
+155
+00:11:34,370 --> 00:11:38,410
+immunity is more important because its suppression
+
+156
+00:11:39,700 --> 00:11:44,140
+can lead to systemic disease لما يكون الخلل في ال
+
+157
+00:11:44,140 --> 00:11:47,840
+T cell او في ال cell mediated immunity ال CMV
+
+158
+00:11:47,840 --> 00:11:51,920
+بيكون قادر على انه يعمل systemic disease بينما لو
+
+159
+00:11:51,920 --> 00:11:55,920
+كان الخلل في ال antibody ما بيعمل systemic
+
+160
+00:11:55,920 --> 00:11:58,900
+disease، اذا من الاهام في هذا الموضوع منها؟ ال
+
+161
+00:11:58,900 --> 00:12:00,040
+cell mediated immunity
+
+162
+00:12:03,060 --> 00:12:07,700
+20% من الأطفال اللي عندهم CMV during gestation
+
+163
+00:12:07,700 --> 00:12:10,800
+show clinically apparent manifestation of
+
+164
+00:12:10,800 --> 00:12:13,700
+cytomegalic inclusion disease أنا وعدتكوا في أول
+
+165
+00:12:13,700 --> 00:12:16,760
+المحاضرة أقولكوا إيش يعني cytomegalic inclusion
+
+166
+00:12:16,760 --> 00:12:21,760
+disease مثل microcephaly رأس صغيرة seizure
+
+167
+00:12:21,760 --> 00:12:25,780
+انقباضات فقدر للسمع deafness jaundice اللي هو
+
+168
+00:12:25,780 --> 00:12:29,700
+الإصفرار بالاضافة إلى البربرة أو الإذرقال
+
+169
+00:12:32,830 --> 00:12:36,910
+تضخم في الكابل و تضخم في إبتحال الـ mental
+
+170
+00:12:36,910 --> 00:12:41,130
+retardation اللي هو التخلف جونه العقلي و تطلع على
+
+171
+00:12:41,130 --> 00:12:44,570
+الجملة بتقول cytomegalic inclusion disease is one
+
+172
+00:12:44,570 --> 00:12:47,690
+of the leading causes of mental retardation in the
+
+173
+00:12:47,690 --> 00:12:52,850
+united states يبجى هذا الفيروس له ضرر كبير أو أثر
+
+174
+00:12:52,850 --> 00:12:58,990
+كبير على الأجيال المستقبلية حيث أنه يسبب جونه
+
+175
+00:12:58,990 --> 00:13:00,170
+mental retardation
+
+176
+00:13:04,470 --> 00:13:08,390
+Infected infants، وهذه نقطة كتير مهمة، can
+
+177
+00:13:08,390 --> 00:13:13,370
+execrate CMV especially in the urine، كلمة
+
+178
+00:13:13,370 --> 00:13:16,170
+especially in the urine بتذكرنا بمعلومة مين؟
+
+179
+00:13:16,170 --> 00:13:22,450
+بمعلومة إنه CMV can persist in kidneys for years،
+
+180
+00:13:22,450 --> 00:13:25,570
+يبقى ممكن يستمر إلى سنوات في ال kidneys، يبقى حصله
+
+181
+00:13:25,570 --> 00:13:27,670
+shedding عبر اللي هو ال urine
+
+182
+00:13:30,620 --> 00:13:34,240
+مازلنا في الـ clinical finding قلنا ال disease كان
+
+183
+00:13:34,240 --> 00:13:37,200
+او one of the diseases caused by CMV حيث انها
+
+184
+00:13:37,200 --> 00:13:40,680
+heterofile infectious mononucleosis او heterofile
+
+185
+00:13:40,680 --> 00:13:44,060
+negative infectious mononucleosis ال
+
+186
+00:13:44,060 --> 00:13:47,440
+characteristic سبعته lethargy و كلمة lethargy يعني
+
+187
+00:13:47,440 --> 00:13:52,320
+خمول، خمول يعني عدم الرغبة في أداء أي عمل أو
+
+188
+00:13:52,320 --> 00:13:57,790
+القدرة حتى على أداء هذه الأعمالو abnormal
+
+189
+00:13:57,790 --> 00:14:01,910
+lymphocytes احفظوا الجرمتين الكلمتين هدوله لأن
+
+190
+00:14:01,910 --> 00:14:05,930
+هدوله هيتكرروا في مين؟ هيتكرروا في الابشتين بار و
+
+191
+00:14:05,930 --> 00:14:09,890
+بايرس لما اتكلم عن heterofile postive antibody إيش
+
+192
+00:14:09,890 --> 00:14:14,670
+يعني abnormal lymphocytes؟ كلكم بتعرفوا أن ال
+
+193
+00:14:14,670 --> 00:14:21,150
+lymphocyte عبارة عن خليةيحتل .. او تحتل النواء
+
+194
+00:14:21,150 --> 00:14:26,990
+الدوس الأكبر منها، مظبوط؟ الآن تخيل أن عندي
+
+195
+00:14:26,990 --> 00:14:33,850
+لينفوسات بهذا الشكل، دوسة كبيرة صار في vacuum
+
+196
+00:14:33,850 --> 00:14:38,190
+لعندي، وفي عندي shrinkage لمين؟ ل .. اللي هو
+
+197
+00:14:38,190 --> 00:14:42,650
+النواء، وقد تبدو كأنها lopulated وكانها مفصصة،
+
+198
+00:14:42,650 --> 00:14:45,570
+يعني مقطعة إلى أرزاق، زي مين؟ زي النتروفيل، فاكرين
+
+199
+00:14:45,570 --> 00:14:47,890
+نتروفيل كيف؟ نتروفيل كما اتزهج
+
+200
+00:14:58,710 --> 00:15:02,650
+abnormal lymphocytes في كمان finding مهمة انه في
+
+201
+00:15:02,650 --> 00:15:06,290
+ال blood film الطبيعي ايش اكتر خلايا بنشوفها بنات
+
+202
+00:15:06,290 --> 00:15:10,680
+هنا؟نيتروفيل هنا بنشوف absolute lymphocytosis
+
+203
+00:15:10,680 --> 00:15:14,340
+بمعنى انه كل ال fields عبارة عن ايه؟ عبارة عن
+
+204
+00:15:14,340 --> 00:15:17,800
+lymphocytes حوالي ثلاثين بالمائة من هذه ال
+
+205
+00:15:17,800 --> 00:15:23,140
+lymphocytes او اكثر abnormal lymphocytes والعلماء
+
+206
+00:15:23,140 --> 00:15:27,200
+يعني بيقولوا انه هذه ال abnormal lymphocytes هي
+
+207
+00:15:27,200 --> 00:15:35,380
+عبارة عن T cells تلاحق ال B cellsT-cells تلاحق من
+
+208
+00:15:35,380 --> 00:15:38,820
+الـB-cells فاكرين قبل قليل يقولون أن البكتيريا
+
+209
+00:15:38,820 --> 00:15:42,140
+تستطيع البقاء أو العفو من الفلوسيات تستطيع البقاء
+
+210
+00:15:42,140 --> 00:15:46,240
+داخل الخلايا الدم البيضاء تمام الـeukocytes اللي
+
+211
+00:15:46,240 --> 00:15:53,960
+من ضمنها الـB-cells في كمان يعني مجموعة من الأمراض
+
+212
+00:15:53,960 --> 00:15:59,750
+الأخرى غير اللي هم ال ..الـ heterofile، negative
+
+213
+00:15:59,750 --> 00:16:02,650
+mononucleosis ممكن عندنا pneumonia و يكون عندنا
+
+214
+00:16:02,650 --> 00:16:07,130
+أيضا hepatitis ممكن كمان عندنا infection في ال
+
+215
+00:16:07,130 --> 00:16:12,090
+intestinal tract خاصة في مرضى اللي هم ال aids و
+
+216
+00:16:12,090 --> 00:16:15,910
+أيضا مرضى ال aids ممكن يكون عرضة لما يسمى ال
+
+217
+00:16:15,910 --> 00:16:19,470
+retinitis التهاب ال retina في العين وهذا قد يؤدي
+
+218
+00:16:19,470 --> 00:16:23,730
+إلى blindness إذا ال cytomegalovirusنسبة كبيرة من
+
+219
+00:16:23,730 --> 00:16:27,150
+.. من .. من .. من سكان الكوكب والأرض موصابين بهذا
+
+220
+00:16:27,150 --> 00:16:33,570
+الفيروس معظم الإصابات صح asymptomatic لكن لما
+
+221
+00:16:33,570 --> 00:16:37,930
+بتكلم على تسعين بالمائة من الناس لو قلتلك point
+
+222
+00:16:37,930 --> 00:16:41,090
+zero zero واحد في المائة من هؤلاء الناس قد يصاب
+
+223
+00:16:41,090 --> 00:16:45,690
+بمرض فهذا رقم أو هذا رقم كبير جدالأن أنا بتكلم على
+
+224
+00:16:45,690 --> 00:16:49,870
+percentage صغيرة من رقم بخم اللي هو عدد سكان
+
+225
+00:16:49,870 --> 00:16:54,330
+العالم، فبالتالي ال CMV من الفيروسات اللي بتحتل
+
+226
+00:16:54,330 --> 00:16:57,510
+الصدارة في اهتمام العلماء والدارسين
+
+227
+00:17:00,010 --> 00:17:02,450
+الـ laboratory diagnosis هي أول مرة بنشوف حيثما
+
+228
+00:17:02,450 --> 00:17:07,030
+shell virus وهي commercially available technique
+
+229
+00:17:07,030 --> 00:17:10,650
+for the detection of some viruses منها اللي هو ال
+
+230
+00:17:10,650 --> 00:17:17,490
+CMV لكن اليوم عندنا ال PCR based assays موجودة لل
+
+231
+00:17:17,490 --> 00:17:23,410
+detection of ال CMV وممكن أيضا نستخدم ال
+
+232
+00:17:23,410 --> 00:17:27,320
+fluorescent antibody stainingكتقنية سيرولوجية
+
+233
+00:17:27,320 --> 00:17:32,380
+للكشف عن هذا الفيروس ممكن كمان في ال urine مش
+
+234
+00:17:32,380 --> 00:17:36,820
+هنجونا قريب شوية انه الفيروس موجود في ال urine لو
+
+235
+00:17:36,820 --> 00:17:39,600
+عملنا centrifugation لل urine و انتوا عملته تحت ال
+
+236
+00:17:39,600 --> 00:17:42,900
+urine و لسه عملته مش بتعمله centrifugation بتاخد
+
+237
+00:17:42,900 --> 00:17:46,420
+ال sediment الآن من ال sediments لو احنا شفنا
+
+238
+00:17:46,420 --> 00:17:50,460
+giant cells خلايا كبيرة هذه ال giant cell ممكن
+
+239
+00:17:50,460 --> 00:17:55,940
+ناخدها و نعملهافيكسايشن على شريحة و نصبغها ب
+
+240
+00:17:55,940 --> 00:18:00,500
+immunofluorescent labelled antibody لل CMV و بعدين
+
+241
+00:18:00,500 --> 00:18:03,480
+نشوفها تحت ال fluorescent microscope و نعرف إذا
+
+242
+00:18:03,480 --> 00:18:08,880
+كان موجود ال CMV ولا غير موجود و أكيد ال .. ال
+
+243
+00:18:08,880 --> 00:18:13,020
+owl's eye أصبحت لدينا لها cytomegalo inclusion
+
+244
+00:18:13,020 --> 00:18:16,440
+اللي هي intra nuclear inclusion اللي موجودة في بعض
+
+245
+00:18:16,440 --> 00:18:21,720
+الخلاياالنقطة الأخيرة اللي هي الـ four-fold
+
+246
+00:18:21,720 --> 00:18:27,600
+increase in antibody titers IGG فحصلنا اليوم
+
+247
+00:18:27,600 --> 00:18:32,700
+وفحصلنا بعد عشر أيام إلى أربعاشر يوم ووجدنا ان
+
+248
+00:18:32,700 --> 00:18:35,580
+ارتفاع ما يعادل
+
+249
+00:18:37,730 --> 00:18:40,430
+أما تركيزه في المرحلة الأولى، هذا يعتبر أيضًا
+
+250
+00:18:40,430 --> 00:18:44,050
+diagnostic، لكن اتفقنا إن هذا ال diagnosis غير
+
+251
+00:18:44,050 --> 00:18:48,810
+مفيد في حالة المريض نفسه، إنما هو تأكيد للحالة ك
+
+252
+00:18:48,810 --> 00:18:50,710
+Epidemiological Survey
+
+253
+00:18:53,850 --> 00:18:58,070
+كمان في PCR Assays مش بس في ال .. ال .. ال .. ال
+
+254
+00:18:58,070 --> 00:19:02,150
+.. من ال urine او من ال saliva و انما ايضا كمان من
+
+255
+00:19:02,150 --> 00:19:05,550
+ال body fluids زي ال spinal fluid و حتى الأم
+
+256
+00:19:05,550 --> 00:19:09,350
+الحامل من ال amniotic fluid اللي هو السائق الجنيني
+
+257
+00:19:09,350 --> 00:19:14,430
+تمام؟ من ال amniotic fluid are also used فيه كمان
+
+258
+00:19:14,430 --> 00:19:18,490
+شغل مهمة و طول امرا هنقولكوا انه الكشف عن ال
+
+259
+00:19:18,490 --> 00:19:24,020
+antibody ليس بنفس القيمة للكشف عن ال antigenفيه
+
+260
+00:19:24,020 --> 00:19:26,520
+أنتجين اسمه PP65
+
+261
+00:19:28,200 --> 00:19:31,460
+كأول ما بنكشف عن antigen يبقى بنكشف عن component
+
+262
+00:19:31,460 --> 00:19:34,580
+من ال virus فوجود ال .. فوجود هذا ال component
+
+263
+00:19:34,580 --> 00:19:38,500
+معناه وجود هذا ال virus مافيش جدال انه موجود او
+
+264
+00:19:38,500 --> 00:19:41,600
+غير موجود زي ال antibody ال antibody كنا نقول يمكن
+
+265
+00:19:41,600 --> 00:19:44,620
+من previous infection يمكن carrier مظبوط يمكن
+
+266
+00:19:44,620 --> 00:19:49,520
+vaccination يمكن ويمكن لكن ال antigen مدام هو جزء
+
+267
+00:19:49,520 --> 00:19:53,460
+من مين من ال virus وبتالي إذا وجدناه بيكون ال
+
+268
+00:19:53,460 --> 00:19:54,720
+infection موجود
+
+269
+00:19:57,350 --> 00:20:02,610
+فما هو PP65؟ هو يبارح عن بروتين موجود في
+
+270
+00:20:02,610 --> 00:20:08,410
+الـNucleocapsid تبع الـCMV و يمكن أن يتم اكتشافه
+
+271
+00:20:08,410 --> 00:20:13,670
+داخل الـinfected leukocytes باستخدام مواصلة
+
+272
+00:20:13,670 --> 00:20:19,130
+فلوريسن مسمى مونوكلونال أنتيبادي، إذن الـPP65 هو
+
+273
+00:20:19,130 --> 00:20:23,770
+تجارب مؤكدة إذا وجدنا معنى الحاجة أن الـCMV موجود
+
+274
+00:20:26,390 --> 00:20:32,150
+التريتمنت برضه antivirals كتيرة GANSYCLOVERE
+
+275
+00:20:32,150 --> 00:20:36,470
+مارعيها اسمها؟ مارعيها ال GANSYCLOVERE ولا
+
+276
+00:20:36,470 --> 00:20:39,750
+GANSYCLOVERE لما مارهش حقيقه اللي مارعيها ولا
+
+277
+00:20:39,750 --> 00:20:44,270
+CYCLOVERE هذا ولا GANSYCLOVERE تمام؟ فوسكر نت مار
+
+278
+00:20:44,270 --> 00:20:48,470
+معانا لما قلنالكوا انه اي resistant للا CYCLOVERE
+
+279
+00:20:48,470 --> 00:20:53,550
+ماعطيه فوسكر نت unlike HSV and Varicellar Zoster
+
+280
+00:20:53,550 --> 00:21:01,300
+Virus طلعوا الآن الجملة دىCMV is largely resistant
+
+281
+00:21:01,300 --> 00:21:06,640
+to mean to اللي هو أسائكلوفير إذا ال resistance زي
+
+282
+00:21:06,640 --> 00:21:09,440
+ما احنا بنقول الـ cephalococcus aureus is highly
+
+283
+00:21:09,440 --> 00:21:12,600
+resistant to penicillins أكتر من الـ streptococcus
+
+284
+00:21:12,600 --> 00:21:16,080
+بما أنه ينتهي جرام positive هي من نفس العائلة وفي
+
+285
+00:21:16,080 --> 00:21:19,620
+resistance عند بعض الفيروسات أعلى من resistance
+
+286
+00:21:19,620 --> 00:21:21,280
+لفيروسات أخرى
+
+287
+00:21:24,730 --> 00:21:29,410
+فيموفرسين و هذا الفيموفرسين لازم نحط تحته خط و
+
+288
+00:21:29,410 --> 00:21:35,410
+نتكلم عنه بإعجاب لأنه unique drug لم يستخدم و لم
+
+289
+00:21:35,410 --> 00:21:39,370
+يعتمد غيره في الدنيا من نفس الصنف و نفس الفكرة
+
+290
+00:21:39,370 --> 00:21:45,470
+تسمع بحياتي اسمها antisense؟ antisense هاي DNA
+
+291
+00:21:45,470 --> 00:21:51,840
+single strand لو عملتله أنا من عندى نسخةتركب عليه
+
+292
+00:21:51,840 --> 00:21:57,980
+بمعنى انه to complement it هذا ال DNA او ال RNA
+
+293
+00:21:57,980 --> 00:22:04,880
+اسمه antisense العلماء فكروا جاله انه لماذا لا
+
+294
+00:22:04,880 --> 00:22:10,320
+نصنع antisense لكل الجينات المؤذية والضارة في
+
+295
+00:22:10,320 --> 00:22:15,560
+البكتيريا؟والفكرة لقت استحسان في زمن من الأزمين
+
+296
+00:22:15,560 --> 00:22:18,900
+الولماء كلهم جالوا antisense technology، antisense
+
+297
+00:22:18,900 --> 00:22:22,680
+technology ستطور العالم، وبدأ العلماء يبدأوا
+
+298
+00:22:22,680 --> 00:22:29,380
+يبحثوا في هذا المجال، نجحوا في إحداث طفرة في إنه
+
+299
+00:22:29,380 --> 00:22:33,780
+يصنعوا antisense، لكن للأسف التكنولوجيا كلها ما
+
+300
+00:22:33,780 --> 00:22:38,630
+نجحتليش؟ لأن في معيقات كيف لنا أن ندخل الـ
+
+301
+00:22:38,630 --> 00:22:43,650
+Antisense هذا إلى الخلايا بشكل سلس مش كل المادة
+
+302
+00:22:43,650 --> 00:22:47,970
+الوراثية ممكن تدخل إلى داخل الخلايا فالمهم ماكانش
+
+303
+00:22:47,970 --> 00:22:54,750
+في نجاحات كبيرة in vivo يعني داخل الجسم إلا لهذا
+
+304
+00:22:54,750 --> 00:23:01,030
+المركب اللي اسمه فوموفيرسين فوموفيرسين يحقن في
+
+305
+00:23:01,030 --> 00:23:01,570
+العين
+
+306
+00:23:04,550 --> 00:23:12,070
+Ocular تمام يحقن في العين في العين Intraocular إيش
+
+307
+00:23:12,070 --> 00:23:16,430
+هو هذا كلام مرة الفومفرسين؟ هو عبارة عن antisense
+
+308
+00:23:16,430 --> 00:23:20,630
+antisense الآن هو ال antisense الوحيد ال approved
+
+309
+00:23:20,630 --> 00:23:24,510
+for human use مافيش غيره يبقى أنتوا عرفتوا اليوم
+
+310
+00:23:24,510 --> 00:23:30,150
+مركب مشهور متفرد في الطب اللي هو الفومفرسين كشكل
+
+311
+00:23:30,150 --> 00:23:32,610
+من أشكال ال antisense drugs
+
+312
+00:23:35,910 --> 00:23:41,730
+الـ Prevention، there is no vaccine for this virus
+
+313
+00:23:41,730 --> 00:23:47,590
+الـGanciclovir
+
+314
+00:23:47,590 --> 00:23:50,690
+can suppress progressive arthritis in AIDS
+
+315
+00:23:50,690 --> 00:23:53,030
+patients وانتوا عارفين الـ AIDS patients
+
+316
+00:23:53,030 --> 00:23:57,030
+بيقولنالكوا اننا مشكلتين معاهم، اننا ال viral load
+
+317
+00:23:57,030 --> 00:24:01,190
+واننا
+
+318
+00:24:01,190 --> 00:24:09,810
+ال CD4 countكل ما انخفض هذا CD4 count وكل ما ارتفع
+
+319
+00:24:09,810 --> 00:24:14,610
+ال viral load كل ما ضعفت المناعة وهذا من قياس صار
+
+320
+00:24:14,610 --> 00:24:19,110
+جزء من ال routine فحص مرضى ال AIDS إذا انخفض ال
+
+321
+00:24:19,110 --> 00:24:25,410
+CD4 عن 200 cells تمام؟ هذا مؤشر أن ال viral load
+
+322
+00:24:25,410 --> 00:24:29,570
+شماله عالي وبالتالي هذا بيستلزم أن نعطيه
+
+323
+00:24:29,570 --> 00:24:34,910
+Prophylaxis طبعا
+
+324
+00:24:35,920 --> 00:24:40,120
+الـ Prophylaxis معناها إن أنا باعطي drug مش لمرض
+
+325
+00:24:40,120 --> 00:24:46,760
+موجود، لمرض محتمل، لمرض محتمل طبعا قايمة طويلة يا
+
+326
+00:24:46,760 --> 00:24:50,020
+بنات من العقاقير اللي هتواطى لهذا المريض منها
+
+327
+00:24:50,020 --> 00:24:53,820
+Antifungal منها Antibiotics عادية للبكتيريا ومنها
+
+328
+00:24:53,820 --> 00:24:58,320
+Antivirals فبالتالي مرضى ال AIDS, Brunelco يلهم
+
+329
+00:24:58,320 --> 00:25:03,780
+special situation في ال viral disease okay
+
+330
+00:25:06,830 --> 00:25:10,590
+الاطفال ال infants اللي عندهم cytomegalic
+
+331
+00:25:10,590 --> 00:25:12,930
+inclusion diseases مش هنقول نجرب شويه أنه دول ال
+
+332
+00:25:12,930 --> 00:25:16,730
+infants بيعملوا execution ل .. ال .. ال .. ال
+
+333
+00:25:16,730 --> 00:25:20,450
+virus for several years in their urine they should
+
+334
+00:25:20,450 --> 00:25:23,470
+be kept in isolated from other infants يعني
+
+335
+00:25:23,470 --> 00:25:25,550
+الأطفال هدول اللي بينولدوا و عندهم هذا المشكلة
+
+336
+00:25:25,550 --> 00:25:29,950
+لازم نفصلهم عن الأطفال الآخرين blood for
+
+337
+00:25:29,950 --> 00:25:33,530
+transfusion to newborns اللي قالوا احنا على بنك
+
+338
+00:25:33,530 --> 00:25:38,620
+الدم احناواسألناهم عن الفحوصات اللى بتجرى لواحدة
+
+339
+00:25:38,620 --> 00:25:44,920
+الدم المتبرع بها ال CMV ليس واحدا منها لأن احنا
+
+340
+00:25:44,920 --> 00:25:49,700
+بقولك 90% من الناس عندهم CMV وبالتالي مالفائدة؟
+
+341
+00:25:49,700 --> 00:25:55,200
+مالفائدة؟ تمام؟ يمكن لو احنا اتدجين على هذا الجانب
+
+342
+00:25:55,200 --> 00:26:02,320
+تمام؟ ماحدش هينجل دم للتانى صح؟ فعديها الآن في شرط
+
+343
+00:26:03,180 --> 00:26:08,760
+إنه الـ newborns الأطفال المولدين حديثا الأصل إذا
+
+344
+00:26:08,760 --> 00:26:11,820
+بدنا نعملهم blood transfusion لأي سبب من الأسباب
+
+345
+00:26:11,820 --> 00:26:16,960
+أن يكون هذا الدم خالي من مين؟ من ال CMVإذا كان
+
+346
+00:26:16,960 --> 00:26:20,400
+ممكن .. كما قالت جونيها قبل قليل، فإن فقط أرغن من
+
+347
+00:26:20,400 --> 00:26:25,160
+الـCMV يجب أن يتم تبعه إلى مستخدمين مستخدمين
+
+348
+00:26:25,160 --> 00:26:25,960
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+349
+00:26:25,960 --> 00:26:26,680
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+350
+00:26:26,680 --> 00:26:30,020
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+351
+00:26:30,020 --> 00:26:30,200
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+352
+00:26:30,200 --> 00:26:30,640
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+353
+00:26:30,640 --> 00:26:33,780
+مستخدمين مستخدمين مستخدمين مستخدمين مستخدمين
+
+354
+00:26:33,780 --> 00:26:40,060
+مستخدمين مستخدمين مستخدمين مستخ
+
+355
+00:26:41,820 --> 00:26:46,700
+في تحضير لـ Antibody زي الـ Varicella .. تذكرين ال
+
+356
+00:26:46,700 --> 00:26:52,600
+Varicella؟ ال Vizig؟ Varicella Zoster؟
+
+357
+00:26:54,470 --> 00:26:59,590
+Immunoglobulin اللي قلنا ممكن نعطيها لبعض الناس
+
+358
+00:26:59,590 --> 00:27:04,110
+عشان إما نمنع ال complications تبع ال vaccination
+
+359
+00:27:04,110 --> 00:27:08,710
+اللي موجودة أو نخفف حتى من حالات الناس اللي عندهم
+
+360
+00:27:08,710 --> 00:27:12,830
+زوستر بشكل كبير فينا كمان حالة اسمها cytogam و
+
+361
+00:27:12,830 --> 00:27:16,770
+cytogam معناها gamma globulin for cytomegalovirus
+
+362
+00:27:22,240 --> 00:27:25,440
+هو استخدامه لإيقاف إتصال الـ CMV في المريض في
+
+363
+00:27:29,730 --> 00:27:34,790
+نقلنا كمرة كيليا من CMV positive ل CMV negative
+
+364
+00:27:34,790 --> 00:27:38,450
+وعطينا immunosuppressive agent كنا بالتأكيد
+
+365
+00:27:38,450 --> 00:27:43,330
+الفيروس هينشط عشان ما ينشطش الفيروس ويعمل مشكلة
+
+366
+00:27:43,330 --> 00:27:47,170
+لهذا المريض اللي هو الآن في وضع حرش جدا تمام
+
+367
+00:27:47,170 --> 00:27:53,010
+بنعطيه هذا ال immunoglobulin حتى نخفف عنه ممكنية
+
+368
+00:27:53,010 --> 00:27:58,030
+إصابة بال CMV الفيروس
+
+369
+00:27:59,110 --> 00:28:03,950
+الخامس، الخامس في السلسلة لول ابشتين بار فيروس،
+
+370
+00:28:03,950 --> 00:28:09,450
+بار فيروس حلو وجميل وكمان منتشر بشكل كبير في هذه
+
+371
+00:28:09,450 --> 00:28:09,950
+الدنيا
+
+372
+00:28:13,020 --> 00:28:16,720
+أساسا ارتبط اسمه على مين؟ مع infectious
+
+373
+00:28:16,720 --> 00:28:23,220
+mononucleus، لكن الآن بدنا نرفع إيدينا عن الباقي و
+
+374
+00:28:23,220 --> 00:28:27,440
+نفكر في مين؟ في الابشتين بارفيا، عارفين ليش؟ لأنه
+
+375
+00:28:27,440 --> 00:28:31,680
+هيتميز عنهم كلهم، هو واللي وراه، بينهم cause of
+
+376
+00:28:31,680 --> 00:28:36,080
+cancerتمام؟ هدولة ال .. ال .. ال .. الابيشتين بار
+
+377
+00:28:36,080 --> 00:28:38,880
+فيروس و ال herpes .. human herpes virus type 8
+
+378
+00:28:38,880 --> 00:28:41,220
+التانية اللي بيسببوه ال cancer وبالتالي بنصنفهم
+
+379
+00:28:41,220 --> 00:28:48,800
+تحت مين oncoviruses اللي هي المسببة للكنسر إيش
+
+380
+00:28:48,800 --> 00:28:52,260
+أنواع ال cancer اللي بيسببها؟ طلع بيسبب berkits
+
+381
+00:28:52,260 --> 00:28:55,680
+lymphoma and other lymphomas .. other lymphomas
+
+382
+00:28:55,680 --> 00:28:59,480
+إيش يعني lymphoma؟ infection of the lymphocytes
+
+383
+00:29:00,400 --> 00:29:03,380
+Nasopharyngeal carcinoma و تعالوا نجحى فى عند
+
+384
+00:29:03,380 --> 00:29:07,640
+المصطلحين هدولة Birkitt's lymphoma و
+
+385
+00:29:07,640 --> 00:29:12,220
+Nasopharyngeal carcinoma ارجو انه ننتبه شوية بدون
+
+386
+00:29:12,220 --> 00:29:20,600
+كتابة لأن الموضوع متعلق بتفسير لبعض الظواهر لجوا
+
+387
+00:29:20,600 --> 00:29:24,420
+ان الأطفال الأفريقا إذا وصيبوا بإبشتين بار فيروس
+
+388
+00:29:24,420 --> 00:29:28,410
+بيصير عندهم Birkitt's lymphomaلكن الصينيين لو
+
+389
+00:29:28,410 --> 00:29:31,650
+أصيبوا بال CMV بيصير عندهم nasopharyngeal
+
+390
+00:29:31,650 --> 00:29:37,910
+carcinoma فكيف الفيروس واحد أن ينطقي المرض عند فئة
+
+391
+00:29:37,910 --> 00:29:46,950
+معينة من الناس؟ هل من تفسير؟ فاكرين البيئة؟ لأ في
+
+392
+00:29:46,950 --> 00:29:49,830
+بيئة أهم من البيئة هي اسمها العرق، يعني لو أخدنا
+
+393
+00:29:49,830 --> 00:29:52,270
+واحد أفريقيا و أدينا واحد الصين، هيصير عنده برضه
+
+394
+00:29:52,270 --> 00:29:57,360
+مين؟ Burkitt lymphoma، تمام؟العرق قد يكون طبعاً
+
+395
+00:29:57,360 --> 00:30:00,180
+العرق أكيد له علاقة بالوراثة بال genetics مظبوط
+
+396
+00:30:00,180 --> 00:30:05,220
+ولا لأ لما نقول العرق أصفر تمام أو قوقازي تمام
+
+397
+00:30:05,220 --> 00:30:08,820
+هدول الناس فئة خلينا نقول انه عزله في بعض الجينات
+
+398
+00:30:08,820 --> 00:30:14,340
+أو بعض الجينات تميزه فيها هذا التميز هذا التميز
+
+399
+00:30:14,340 --> 00:30:19,680
+يجعلهم إما immune أو susceptible to certain
+
+400
+00:30:19,680 --> 00:30:24,900
+diseasesوصف الصورة فقد يدخل الفيروس إلى جنسين
+
+401
+00:30:24,900 --> 00:30:31,160
+مختلفين من البشر ويحدث أمراض مختلفة بسبب الاستعداد
+
+402
+00:30:31,160 --> 00:30:36,520
+الوراثي لهؤلاء البشر، تمام؟ هذه نقطة كتير مهمة
+
+403
+00:30:36,520 --> 00:30:40,400
+تستخدم في تفسير بعض الاختلافات في الـ Epidemiology
+
+404
+00:30:40,400 --> 00:30:41,560
+of the disease
+
+405
+00:30:44,150 --> 00:30:48,870
+الشكل اللي هناك لسان أبيض اسمه ال disease hairy
+
+406
+00:30:48,870 --> 00:30:55,570
+leukoblackia وهي non-malignant يعني مش سرطاني
+
+407
+00:30:55,570 --> 00:31:01,250
+غالبا مشروع في المرضى ال aids برضه
+
+408
+00:31:01,250 --> 00:31:06,330
+زي أخته الفاجين باخترفش عنهم شكلا إلا أنت جينيكالي
+
+409
+00:31:06,330 --> 00:31:10,660
+و طبعا واكيد ال structural geneticsاحفظ الآن بعض
+
+410
+00:31:10,660 --> 00:31:16,300
+المعلومات المتعلقة بهذا الفيروس لم نتطرق لها في
+
+411
+00:31:16,300 --> 00:31:20,340
+الفيروس الأخرى اول حاجة انه انكوجينيك رقم اتنين
+
+412
+00:31:21,050 --> 00:31:24,930
+Heterofil Positive Mononucleosis رقم تلاتة قاعد
+
+413
+00:31:24,930 --> 00:31:28,790
+أتكلم عن أنتجينات داخلية مثلا ال viral capsid
+
+414
+00:31:28,790 --> 00:31:33,390
+antigen ال VCA Viral Capsid Antigen وفي عندي حد
+
+415
+00:31:33,390 --> 00:31:38,710
+اسمها Early Antigen و حد اسمها Nuclear Antigen
+
+416
+00:31:38,710 --> 00:31:42,530
+طبعا Nuclear Antigen هان هي شايفينها و ال EP إيش
+
+417
+00:31:42,530 --> 00:31:48,530
+معناها بيشتين بعض هد محطنهاش يعني حطنا EA هد EPA
+
+418
+00:31:51,160 --> 00:31:58,800
+هؤلاء الانتاجين هم الـ early antigens و ال VCA و
+
+419
+00:31:58,800 --> 00:32:05,980
+ال EPNA هم بعض الأحيان مدعومين للدراسة يعني
+
+420
+00:32:05,980 --> 00:32:11,380
+بتساعدنا في وين في عملية التشخيص فهو لسه early
+
+421
+00:32:11,380 --> 00:32:15,740
+antigen و nuclear antigen و viral capsid antigen
+
+422
+00:32:21,450 --> 00:32:25,190
+بالإضافة إلى ما ذكرناهم فيه أنتجينات أقل أهمية أو
+
+423
+00:32:25,190 --> 00:32:29,270
+على الأقل أقل شهرة نسميها أهمية lymphocyte
+
+424
+00:32:29,270 --> 00:32:31,990
+determined membrane antigen وviral membrane
+
+425
+00:32:31,990 --> 00:32:35,890
+antigens برضه هدولة تم الكشف عنهم في هذا الفيروس
+
+426
+00:32:35,890 --> 00:32:40,490
+يبقى فيه مجموعة أنتجينات كبيرة في الإبشتينبار
+
+427
+00:32:40,490 --> 00:32:47,210
+الويرس ال neutralizing activity is directed
+
+428
+00:32:47,210 --> 00:32:51,020
+against the viral membrane antigenأعتقد كلمة
+
+429
+00:32:51,020 --> 00:32:54,980
+neutralizing activity صارت بالنسبة أنها واضحة ولا
+
+430
+00:32:54,980 --> 00:32:59,300
+مش واضحة، هاي ال virus،
+
+431
+00:32:59,300 --> 00:33:04,120
+هاي ال envelope،
+
+432
+00:33:04,120 --> 00:33:12,050
+الانتجنات تبعته، أي antibody بيعملّي ارتباطمع هذه
+
+433
+00:33:12,050 --> 00:33:16,010
+الانتيجينات، أي انتيجينات تحديدًا، التي هي أصلا
+
+434
+00:33:16,010 --> 00:33:20,650
+ترتبط على مين؟ على ال host cell، إذا لو ال
+
+435
+00:33:20,650 --> 00:33:24,750
+antibody موجود هنا، يبقى مش هترتبط، اللي هو
+
+436
+00:33:24,750 --> 00:33:27,990
+الفيروس مش هترتبط على ال cell، فهذا بنسميه احنا
+
+437
+00:33:27,990 --> 00:33:33,990
+neutralizing antibodyإذا الـ Neutralizing activity
+
+438
+00:33:33,990 --> 00:33:37,630
+is directed against the viral membrane antigen
+
+439
+00:33:37,630 --> 00:33:39,890
+يعني بيبقى أنها أخرجت من ال antibodies produced
+
+440
+00:33:39,890 --> 00:33:44,130
+against this antigen. human are the natural host،
+
+441
+00:33:44,130 --> 00:33:48,710
+polynatural hostEPV infect mainly lymphoid cells
+
+442
+00:33:48,710 --> 00:33:54,310
+وصنفنا هذا على انه ايه جاما herpes viruses قولنا
+
+443
+00:33:54,310 --> 00:33:58,330
+هم alpha beta جاما ال alpha بيصيبوا مين ال
+
+444
+00:33:58,330 --> 00:34:01,210
+epithelial كامة تلاتة بيصيبوا ال epithelial herpes
+
+445
+00:34:01,210 --> 00:34:06,010
+simplex one و two و ال varicella بينما هذا ال
+
+446
+00:34:06,010 --> 00:34:09,210
+virus تمام صنفناه من مين جاما لأنه بيصيب ال
+
+447
+00:34:09,210 --> 00:34:14,940
+lymphoid و ال CMV اللي جاب لهذابيتا ليش بيتا لإنه
+
+448
+00:34:14,940 --> 00:34:19,140
+بصيب variety of tissues تمام أنتجها مختلفة يعني
+
+449
+00:34:19,140 --> 00:34:23,270
+هذه المعلومات ما ننساهاأنا أولا قبل ما أجي على
+
+450
+00:34:23,270 --> 00:34:28,430
+المحاضرة نزلتلكم فيديو على المجموعة تبعتنا على
+
+451
+00:34:28,430 --> 00:34:32,390
+الهرب السيمبليكس type 1 و type 2 هو باللغة
+
+452
+00:34:32,390 --> 00:34:36,610
+الإنجليزية تاما لكن بشكل توضيحي وكأنكوا حضرتوا
+
+453
+00:34:36,610 --> 00:34:41,170
+المحاضرات معانا هتلاقوا من السهل جدا أنكوا تفهموا
+
+454
+00:34:41,170 --> 00:34:44,210
+كل ما جاء في هذه المحاضرة وهي محاضرة يعني أقل من
+
+455
+00:34:44,210 --> 00:34:51,290
+عشر دقائق ان شاء اللهتمام يبقى it infects من اللي
+
+456
+00:34:51,290 --> 00:34:54,490
+قلنا اللي هو ال lymphoid cell primarily بـ
+
+457
+00:34:54,490 --> 00:34:58,570
+lymphocytes عشان هي قلنا لكوا ال T lymphocyte اللي
+
+458
+00:34:58,570 --> 00:35:02,430
+في الدم absolute lymphocytosis وقلنا لكوا العلماء
+
+459
+00:35:02,430 --> 00:35:06,350
+بيقولوا ان هذه ال lymphocytes هي اللي تلحق ال T
+
+460
+00:35:06,350 --> 00:35:11,250
+lymphocyte هي اللي تلحق ال B lymphocyte Illegently
+
+461
+00:35:11,250 --> 00:35:15,850
+infected cell multiple copies of EPV DNA are found
+
+462
+00:35:15,850 --> 00:35:19,190
+in the cytoplasmof infected B lymphocyte إذا في
+
+463
+00:35:19,190 --> 00:35:22,330
+برضه كمان زي حكاية ال herpes simplex type 1 و type
+
+464
+00:35:22,330 --> 00:35:26,930
+2 إنه في نسخ موجودة في ال cytoplasm بس هتعرفوا إنه
+
+465
+00:35:26,930 --> 00:35:33,370
+كمان في كبز integrated في ال DNA EPV is
+
+466
+00:35:33,370 --> 00:35:38,370
+transmitted through salivaالسليفة من الناس مع
+
+467
+00:35:38,370 --> 00:35:40,070
+إعادة إعادة إعادة إعادة إعادة إعادة إعادة إعادة
+
+468
+00:35:40,070 --> 00:35:40,950
+إعادة إعادة إعادة إعادة إعادة إعادة إعادة إعادة
+
+469
+00:35:40,950 --> 00:35:51,090
+إعادة إعادة إعادة إعادة إعادة إعادة إعادة
+
+470
+00:35:51,090 --> 00:35:53,030
+إعادة إعادة إعادة إعادة إعادة إعادة إعادة إعادة
+
+471
+00:35:53,030 --> 00:35:54,350
+إعادة إعادة إعادة إعادة إعادة إعادة إعادة إعادة
+
+472
+00:35:54,350 --> 00:36:05,830
+إعادة إعادة إعادة إعادة إعادة إعادة إع
+
+473
+00:36:06,090 --> 00:36:12,050
+حضرة انتقال ال EPV عبر هذه الطريقة نادرة نادرة من
+
+474
+00:36:12,050 --> 00:36:16,090
+انتقال عن طريق الدم EPV infection is one of the
+
+475
+00:36:16,090 --> 00:36:20,710
+most common infections worldwide more than 90% of
+
+476
+00:36:20,710 --> 00:36:23,890
+adults في الولايات المتحدة are or having
+
+477
+00:36:23,890 --> 00:36:30,630
+antibodies برضه متكلم عن رقم ضخم جداإذا لو أنا
+
+478
+00:36:30,630 --> 00:36:35,390
+قلتلكوا إنه بعد هال 4،5 محاضرات الأخيرة، بعد ال
+
+479
+00:36:35,390 --> 00:36:38,630
+Herpes Simplex Type 1 و Type 2 و ال Varicella
+
+480
+00:36:38,630 --> 00:36:43,610
+Zoster و ال CMV و حضرت هذا اللي هو ال Epstein-Barr
+
+481
+00:36:43,610 --> 00:36:46,950
+Virus، أنا تعتقدوا إن الفيروسات بتلعب دور في
+
+482
+00:36:46,950 --> 00:36:52,810
+حياتنا أكبر منها تسبب لنا أمراض؟أنا أصبحت أشك بإنه
+
+483
+00:36:52,810 --> 00:36:57,070
+هي لها دور أكبر بكثير منها بس بتاعة مننا بعض
+
+484
+00:36:57,070 --> 00:37:02,270
+الأمراض طالما أنها بتاعة مننا جاعة integration في
+
+485
+00:37:02,270 --> 00:37:07,450
+ال DNA تبعها داخل الخليان، تمام؟ وبعض العلماء
+
+486
+00:37:07,450 --> 00:37:10,810
+اكتشف إنه كتير من ال sequence تبع ال genome تبعنا
+
+487
+00:37:11,720 --> 00:37:16,620
+جزء منه Viral بمعنى أنه يطابق اللي هو الفيروسات
+
+488
+00:37:16,620 --> 00:37:23,220
+فلابد أن يكون هناك دور محتمل نحن الآن نجهله كما
+
+489
+00:37:23,220 --> 00:37:26,720
+كنا نجهل دور البكتيريا في السابق في أمانة وصلنا
+
+490
+00:37:26,720 --> 00:37:30,060
+لأيام اكتشفنا انه له أدوار عظيمة قد نكتشف في يوم
+
+491
+00:37:30,060 --> 00:37:34,520
+من الأيام ان الفيروسات ليست فقط موجودة لإيذانه
+
+492
+00:37:34,520 --> 00:37:37,160
+انما ممكن يكون في أسباب أخرى
+
+493
+00:37:40,290 --> 00:37:43,430
+Infection in the first few years of life is
+
+494
+00:37:43,430 --> 00:37:47,010
+usually asymptomatic. Early infection tends to
+
+495
+00:37:47,010 --> 00:37:51,150
+occur in individuals in lower socioeconomic groups
+
+496
+00:37:51,150 --> 00:37:54,190
+يعني
+
+497
+00:37:54,190 --> 00:37:59,690
+الفئات المهمشة مجتمعيا يعني الفقراء الفقراء او
+
+498
+00:37:59,690 --> 00:38:03,190
+المحتاجين هم الناس اللي بتظهر فيهم العرض هذه المرض
+
+499
+00:38:03,190 --> 00:38:07,660
+مميز بين الفقير والغنيطب عليش هدول الناس بتظهر
+
+500
+00:38:07,660 --> 00:38:13,340
+فيهم اللي هو socio-economic groups؟ بتكون تعرفوا
+
+501
+00:38:13,340 --> 00:38:20,010
+أن وجود أو توفر المال هو سبب لأكثر من شغلةمنها
+
+502
+00:38:20,010 --> 00:38:26,030
+مستوى النظافة العام مظبوط عند المقدرين أكيد ممكن
+
+503
+00:38:26,030 --> 00:38:29,270
+يكون أفضل من اللي غير المقدرين لأن النظافة اللي
+
+504
+00:38:29,270 --> 00:38:33,690
+مستلزمة منها المياه حاسب المثال والمياه تكلفة
+
+505
+00:38:33,690 --> 00:38:42,350
+الصابون النظافة للمنزل نفسه النظافة دورية للمكان
+
+506
+00:38:42,350 --> 00:38:47,470
+تستلزم أيضا أن يكون فيه مصاريف جارية لكن اللي أهم
+
+507
+00:38:47,470 --> 00:38:55,570
+من ذلك هوالغذاء، في علاقة بين الغذاء وسوء التقضية
+
+508
+00:38:55,570 --> 00:39:04,360
+والفقر والضعف المناعة وضعف المناعةسوء التغذية وغير
+
+509
+00:39:04,360 --> 00:39:06,560
+هذا الكلام معروف من زمان يعني ال tuberculosis على
+
+510
+00:39:06,560 --> 00:39:10,100
+سبيل المثال من الأمراض المشهوانة بتصيب الناس اللي
+
+511
+00:39:10,100 --> 00:39:13,620
+هم مابيتغذوش كويس سواء كانوا فقراء أو غير فقراء
+
+512
+00:39:13,620 --> 00:39:18,520
+لكن سوء التغذية عندهم عالي وبالتالي في علاقة بين
+
+513
+00:39:18,520 --> 00:39:23,540
+الفقر وسوء التغذية وسوء التغذية و المناعة تمام
+
+514
+00:39:23,540 --> 00:39:26,780
+فربما يكون هذا هو السبب أنه في انتشار
+
+515
+00:39:29,270 --> 00:39:32,330
+لل .. ال .. ال disease بين ال lower socioeconomic
+
+516
+00:39:32,330 --> 00:39:36,470
+group هذا باين في ال children في ال adult life
+
+517
+00:39:36,470 --> 00:39:41,990
+usually بيكون college students اللي هم طلبت
+
+518
+00:39:41,990 --> 00:39:43,150
+الجامعات
+
+519
+00:39:52,490 --> 00:39:56,050
+المكان الـ infection الأساسي بيحدث غالبا في الـ
+
+520
+00:39:56,050 --> 00:39:58,770
+Oropharynx، أنا قولكوا بنتقل mainly عبر السلايفة،
+
+521
+00:39:58,770 --> 00:40:02,750
+Oropharynx بيصل للـ blood و من ال blood طبعا
+
+522
+00:40:02,750 --> 00:40:08,100
+بيستهدف مين قلنا الـ B lymphocytesCytotoxic T
+
+523
+00:40:08,100 --> 00:40:11,400
+cells زي ما ذكرناها قبل قليل قلنا لكوا انه هي ال
+
+524
+00:40:11,400 --> 00:40:15,700
+normal lymphocyte طلعوا عن نواة النواة حجمها ماخد
+
+525
+00:40:15,700 --> 00:40:20,060
+تقريبا كل الخلية بينما هنا في عندي فرار كبير ففي
+
+526
+00:40:20,060 --> 00:40:24,380
+شرنكش وفي vaculation يعني تفريغ في اللي هو ال
+
+527
+00:40:24,380 --> 00:40:29,140
+cytoplasm تبع الليمف وكما ذكرت اكتر من تلاتين
+
+528
+00:40:29,140 --> 00:40:32,460
+بالمائة من ال lymphocytes الموجودة في blood film
+
+529
+00:40:32,460 --> 00:40:36,240
+هتكون في هذا الحالة قلنا atypical lymph
+
+530
+00:40:41,540 --> 00:40:47,800
+الكشف عن ال IGM و IGG لل VCA ايش ال VCA قلنا عنه
+
+531
+00:40:47,800 --> 00:40:54,200
+Viral Capsid Antigen كلكم بتعرفوا وجود IGM هو مؤشر
+
+532
+00:40:54,200 --> 00:40:59,100
+على Recent Infection بينما وجود IGG يا بنات لا
+
+533
+00:40:59,100 --> 00:41:05,800
+يعني الا ان هذا المريض عندهخبرة سابقة بهذا المرض
+
+534
+00:41:05,800 --> 00:41:11,040
+هل الخبرة السابقة هل هي حالية ولا قديمة ما بنقدر
+
+535
+00:41:11,040 --> 00:41:14,740
+نعرف إلا بإيقاعات الفحص مرة أخرى و four fold
+
+536
+00:41:14,740 --> 00:41:19,440
+increase للمستوى
+
+537
+00:41:19,440 --> 00:41:25,940
+طيب يمكن هنا ال immunity بتحتاج مننا وقت أطول فان
+
+538
+00:41:25,940 --> 00:41:28,320
+شاء الله بنخليها لمحاضرة قادمة بإذن الله يعطيكم
+
+539
+00:41:28,320 --> 00:41:28,600
+العافية
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c0c9172c0327bbb6fe0e2c849aabb0dc2c0ba746
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg.srt
@@ -0,0 +1,2247 @@
+1
+00:00:20,820 --> 00:00:22,780
+بسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:22,780 --> 00:00:25,820
+والصلاة والسلام على سيدنا محمد وعلى آله وصحبه ومن
+
+3
+00:00:25,820 --> 00:00:29,520
+ساعد ربي اليوم الدين. محاضرتنا اليوم إن شاء الله 
+
+4
+00:00:29,520 --> 00:00:35,960
+بعنوان الـViral Replication وتعتبر من أهم المواضيع
+
+5
+00:00:35,960 --> 00:00:42,000
+في الـVirology نظرا لاختلاف الطريقة التي تتكاثر بها
+
+6
+00:00:42,000 --> 00:00:46,000
+الفيروسات عن باقي المخلوقات وللاختلاف الداخلي بين
+
+7
+00:00:46,000 --> 00:00:51,840
+هذه الفيروسات يعني نجد أن هناك DNA single-stranded
+
+8
+00:00:51,840 --> 00:00:55,660
+virus أكيد بالتأكيد هيختلف عن الـdouble-stranded و
+
+9
+00:00:55,660 --> 00:00:58,580
+كذلك الأمر بالنسبة للـsingle-stranded أو double
+
+10
+00:00:58,580 --> 00:01:02,780
+-stranded RNA فيروس هيكون فيها نوع من الاختلاف
+
+11
+00:01:02,780 --> 00:01:06,720
+في المحتوى.
+
+12
+00:01:06,720 --> 00:01:09,500
+هذه المحاضرة سيكون إن شاء الله مقدمة بسيطة عن
+
+13
+00:01:09,500 --> 00:01:15,090
+لماذا الفيروسات مختلفة. سيكون هناك كيف ننظر نحن في
+
+14
+00:01:15,090 --> 00:01:18,310
+الـVirology للـreplication of viruses، هل ننظر له
+
+15
+00:01:18,310 --> 00:01:22,010
+بنفس الطريقة اللي بننظر للبكتيريا فيها، ولا بطريقة
+
+16
+00:01:22,010 --> 00:01:26,150
+مختلفة، لأنهم أصلا هم مختلفين، هناك مصطلح اسمه
+
+17
+00:01:26,150 --> 00:01:32,850
+cytopathic effect عندما نقوم بوضع فيروس على خلايا
+
+18
+00:01:32,850 --> 00:01:37,710
+لتنميتها لتنمية هذه الفيروسات نجد أن بعض الفيروسات
+
+19
+00:01:37,710 --> 00:01:42,890
+تقوم بإحداث أثر سلبي في هذه الخلايا. هذا الأثر
+
+20
+00:01:42,890 --> 00:01:48,750
+السلبي يسمى cytopathic effect أو اختصارا CPE. ما
+
+21
+00:01:48,750 --> 00:01:53,590
+يميز هذا الـCPE هو أن الفيروس الذي يحدثه دائما
+
+22
+00:01:53,590 --> 00:01:58,740
+يحدثه. إيش يعني؟ يمكن الاستفادة من شكل الـCPE للتعرف
+
+23
+00:01:58,740 --> 00:02:02,640
+على الفيروس، إذن هي أحد طرق التعرف على الفيروس.
+
+24
+00:02:02,640 --> 00:02:08,720
+سنطرق أيضًا في الـreplication إلى الخطوات المحددة
+
+25
+00:02:08,720 --> 00:02:13,140
+التي من خلالها يتكاثر الفيروس. مثلًا سنتحدث عن
+
+26
+00:02:13,140 --> 00:02:16,620
+الـattachment، عن الـpenetration، عن الـuncoating
+
+27
+00:02:16,960 --> 00:02:22,320
+عن الـearly و الـ genome replication و
+
+28
+00:02:22,320 --> 00:02:26,080
+الـlate protein synthesis عن الـassembly للفيروس و
+
+29
+00:02:26,080 --> 00:02:33,120
+عن الـrelease لهذا الفيروس. سنتحدث أيضًا عن الـ
+
+30
+00:02:33,120 --> 00:02:35,640
+infectious nucleic acid. إيش يعني infectious
+
+31
+00:02:35,640 --> 00:02:40,680
+nucleic acid؟ لكم أن تتخيلوا أن الفيروس مكون رئيسيا
+
+32
+00:02:40,680 --> 00:02:47,220
+من إيش؟ من مادة وراثية ومن capsid. طب يا ترى لو
+
+33
+00:02:47,220 --> 00:02:51,480
+أخذنا الـNucleic Acid لوحده ووضعناه في خلايا، هل
+
+34
+00:02:51,480 --> 00:02:57,480
+سيكون قادرًا على التكاثر وإعادة دورة الحياة للفيروس
+
+35
+00:02:57,480 --> 00:03:01,620
+ولا لا؟ هذا يعتمد، هناك بعض الفيروسات أو بعض
+
+36
+00:03:01,620 --> 00:03:04,840
+المادة اللي بنعطيها للفيروسات مؤدية والبعض الآخر
+
+37
+00:03:04,840 --> 00:03:09,300
+غير مؤدية، ما الذي يحدد؟ سنتعرف على هذا أيضًا في
+
+38
+00:03:09,300 --> 00:03:14,700
+خلال محاضرة الـViral Replication. هنتكلم عن الـViral 
+
+39
+00:03:14,700 --> 00:03:19,760
+mRNA. أول مرة بنتكلم عن جينوم أصلا مكون من RNA
+
+40
+00:03:19,760 --> 00:03:26,000
+فبالتالي كيف الـViral mRNA الناتجة من هذه الـ
+
+41
+00:03:26,000 --> 00:03:31,860
+Genomes كيف تتعامل معها في خلايانها؟ كيف هي الـ
+
+42
+00:03:31,860 --> 00:03:35,300
+استراتيجيات المختلفة لهذه الفيروسات في الـ
+
+43
+00:03:35,300 --> 00:03:38,540
+replication. وآخر نقطة هنتطرق لها في الـreplication
+
+44
+00:03:38,540 --> 00:03:42,410
+في الـViral replication اللي هي الـlysogenic و الـ
+
+45
+00:03:42,410 --> 00:03:45,250
+lysogeny. مصطلح عرفته أنتو في الـEssential
+
+46
+00:03:45,250 --> 00:03:47,970
+Medical Microbiology وعرفته في الـDiagnostic
+
+47
+00:03:47,970 --> 00:03:51,670
+Microbiology لما تحدثنا عن قدرة بعض الفيروسات على
+
+48
+00:03:51,670 --> 00:03:56,690
+الـintegration لدي الجينوم تبعها داخل الجينوم تبع
+
+49
+00:03:56,690 --> 00:04:02,070
+الـhost cell. وقلنا إن هناك أنواع من البكتيريا
+
+50
+00:04:02,070 --> 00:04:06,890
+لا تكن لتكون أصلا سامة أو قادرة على إحداث المرض إلا
+
+51
+00:04:06,890 --> 00:04:10,850
+من خلال وجود فيروس داخلها. وجود الـvirus داخل
+
+52
+00:04:10,850 --> 00:04:14,450
+الخلية هذا اللي بيسميه احنا lysogeny. كلمة وجوده
+
+53
+00:04:14,450 --> 00:04:21,820
+داخل الخلية بشكل مختفي داخل الـgenome. نبدأ بالمقدمة
+
+54
+00:04:21,820 --> 00:04:25,980
+البسيطة اللي وعدناكم فيها وهي أن الفيروسات مختلفة.
+
+55
+00:04:25,980 --> 00:04:30,760
+ما هو وجه الاختلاف في الفيروسات؟ they are obligate
+
+56
+00:04:30,760 --> 00:04:33,780
+intracellular parasites. They cannot replicate
+
+57
+00:04:33,780 --> 00:04:38,580
+independently. يعني لازم داخل خلية وهذه نقطة لم
+
+58
+00:04:38,580 --> 00:04:42,180
+نجدها في المخلوقات الأخرى إلا في بكتيريا من نوعين
+
+59
+00:04:42,180 --> 00:04:47,390
+جُن عنهم كلاميديا and ركيزي. Viruses do not undergo
+
+60
+00:04:47,390 --> 00:04:54,330
+عملية الـsimple binary fission أو الـmitosis و
+
+61
+00:04:54,330 --> 00:05:00,970
+الـmeiosis. إذن الفيروسات مختلفة وبالتالي لازم نعرف
+
+62
+00:05:00,970 --> 00:05:06,970
+كيف الفيروسات بتتكاثر؟ لماذا نريد معرفة التفاصيل
+
+63
+00:05:06,970 --> 00:05:11,520
+تبع تكاثر الفيروسات؟ عارفين ليش؟ لأن معرفتنا
+
+64
+00:05:11,520 --> 00:05:15,900
+بالتفاصيل الدقيقة بتخلينا ناخذ استراتيجيات كيف
+
+65
+00:05:15,900 --> 00:05:21,180
+نوقف هذا التكاثر؟ ماذا يعني بإيقاف التكاثر؟ إيقاف
+
+66
+00:05:21,180 --> 00:05:26,860
+المرض أو علاج المرض، مظبوط؟ إذا الـspecific events
+
+67
+00:05:26,860 --> 00:05:31,520
+اللي بنتكلم عنها ضرورية حتى نعلم ما هي استراتيجية
+
+68
+00:05:31,520 --> 00:05:35,640
+الفيروس في التكاثر وكيف سنكافح هذه الاستراتيجيات.
+
+69
+00:05:36,690 --> 00:05:40,290
+أيضًا نقطة اختلاف مهمة أنه إذا كنا نعرف أن البكتيريا
+
+70
+00:05:40,290 --> 00:05:48,430
+تنقسم من قول 1,2,4,8,16,32,64 لكن الفيروسات بيدخل
+
+71
+00:05:48,430 --> 00:05:53,490
+one virus داخل الخلية وبيطلع بعد عدة ساعات مئات من
+
+72
+00:05:53,490 --> 00:05:58,450
+الـviruses. يبقى بالتأكيد كل ما يتعلق بالـ
+
+73
+00:05:58,450 --> 00:06:01,970
+replication تبقى الـvirus مختلف تماما عن مين؟ عن
+
+74
+00:06:01,970 --> 00:06:08,960
+المخلوقات الأخرى. طيب احنا كدارسين للـ للفيروسات
+
+75
+00:06:08,960 --> 00:06:13,700
+كيف لنا أن نعرف الـreplication في الفيروس؟ هل
+
+76
+00:06:13,700 --> 00:06:18,000
+نعرفه بنفس الطريقة اللي عرفنا فيها الـreplication
+
+77
+00:06:18,000 --> 00:06:23,020
+في البكتيريا؟ بمعنى كنا نتكلم عن lag, log,
+
+78
+00:06:24,100 --> 00:06:27,360
+stationary, death phase. فاكرين الـgrowth curve تبع
+
+79
+00:06:27,360 --> 00:06:31,360
+البكتيريا؟ نعم. يمكن لنا أن نتعامل مع الفيروس بهذه
+
+80
+00:06:31,360 --> 00:06:35,310
+الطريقة. بندخل الفيروسات في الخلايا وبنعد الفيروسات
+
+81
+00:06:35,310 --> 00:06:40,450
+كل ساعة ساعتين تلاتة وممكن نعمل curve لكن في مشكلة
+
+82
+00:06:40,450 --> 00:06:45,910
+هنا إن في لحظة من اللحظات الفيروس هيدخل داخل
+
+83
+00:06:45,910 --> 00:06:51,630
+الخلايا ومش هقدر أعده. أنا مش هقدر أشوفه هيختفي عن
+
+84
+00:06:51,630 --> 00:06:56,390
+ناظري ولا أنا أستطيع أن أقوم بقياسه أصلا. وهذه مشكلة
+
+85
+00:06:56,390 --> 00:07:01,770
+كبيرة. الخيار الثاني أن أنظر إذا التكاثر تبع
+
+86
+00:07:01,770 --> 00:07:05,490
+الفيروسات بطريقة الـspecific events اللي حكينا
+
+87
+00:07:05,490 --> 00:07:11,210
+عنها. Attachment, Penetration, Uncoating, Early mRNA
+
+88
+00:07:11,210 --> 00:07:16,330
+Early Protein, Genome Replication, Late mRNA, Late
+
+89
+00:07:16,330 --> 00:07:20,710
+Protein, بعدين Assembly, بعدين Release. هذه الـ
+
+90
+00:07:20,710 --> 00:07:25,290
+specific event. إذا الخطوة الأولى أن تطلع عليها كـ
+
+91
+00:07:25,290 --> 00:07:29,790
+growth curve وتطلع على الفقرة أو الفترة ما بين
+
+92
+00:07:29,790 --> 00:07:34,670
+واحد وما بين خمسة الفيروس غير موجود البتة. ما احنا
+
+93
+00:07:34,670 --> 00:07:37,190
+احنا بدنا الفيروس. واحد على المنطقة اللي شايفينها
+
+94
+00:07:37,190 --> 00:07:41,330
+هاي. احنا بنتكلم على one single virus دخلناها في
+
+95
+00:07:41,330 --> 00:07:46,690
+الخلايا أو في الـ في الـgrowth يعني اختفى وفترة
+
+96
+00:07:46,690 --> 00:07:50,610
+الاختفاء بيسموها eclipse period. Eclipse يعني الكسوف.
+
+97
+00:07:50,610 --> 00:07:56,250
+تمام. اختفى عن الأنظار وبعد عدة ساعات بدأ يظهر
+
+98
+00:07:56,250 --> 00:08:01,230
+المادة الوراثية تبعه وبيظهر الفيروس نفسه، إذا هذه
+
+99
+00:08:01,230 --> 00:08:05,230
+تشبه الـgrowth curve تبع مين؟ تبع البكتيريا، لكن
+
+100
+00:08:05,230 --> 00:08:09,710
+كما ذكرت لكم أحد عيوبها إن في عندي فترة اختفاء لا
+
+101
+00:08:09,710 --> 00:08:14,420
+أستطيع قياس الفيروس فيها. الـcytopathic effect
+
+102
+00:08:14,420 --> 00:08:19,160
+التعريف اللي ذكرناه وقلنالكم هو التأثير الحاصل على
+
+103
+00:08:19,160 --> 00:08:24,000
+الخلايا التي ينمو عليها الفيروس. وكونكم لسه ما
+
+104
+00:08:24,000 --> 00:08:28,460
+اتعلمتوش كيف الفيروس أصلا بينمو وبيتكاثر في المعمل
+
+105
+00:08:28,460 --> 00:08:34,340
+بدنا نوضحلكم مثلًا لو افترضنا هذا الجوال عبارة عن
+
+106
+00:08:34,340 --> 00:08:42,380
+بطل شفافة. ويلها عنق وغطاء. وادخلنا من هذا الغطاء
+
+107
+00:08:42,380 --> 00:08:47,920
+مادة مغذية وادخلنا خلايا آدمية. الخلايا الآدمية
+
+108
+00:08:47,920 --> 00:08:52,120
+نفترض أنها من أي عضو من أعضاء الجسم. لما تتكاثر
+
+109
+00:08:52,120 --> 00:08:57,500
+الخلايا الآدمية جوا، تتكاثرش وبتكون أنه عضو، تتكاثر
+
+110
+00:08:57,500 --> 00:09:04,000
+وبتكون طبقة سطحية monolayer. طبقة واحدة من الخلايا.
+
+111
+00:09:04,940 --> 00:09:09,480
+هذا النوع من الخلايا أستطيع أن أفحصه تحت الـ
+
+112
+00:09:09,480 --> 00:09:12,840
+microscope وأرى ما يسمى بالـnormal morphology
+
+113
+00:09:12,840 --> 00:09:17,840
+الشكل الطبيعي لهذه الخلايا. تمام؟ وكل نوع خلايا له
+
+114
+00:09:17,840 --> 00:09:23,000
+normal morphology. لو وضعنا virus عليه والـvirus
+
+115
+00:09:23,000 --> 00:09:27,820
+قلنا لكم من النوع اللي بيدمر الخلايا. تمام؟ بيدمرها
+
+116
+00:09:27,820 --> 00:09:33,510
+كل مرة بنفس الطريقة. التدمير هذا بنسميه cytopathic
+
+117
+00:09:33,510 --> 00:09:37,690
+effect. كيف ممكن أفحصه؟ مرة أخرى تحت الـmicroscope
+
+118
+00:09:37,690 --> 00:09:40,810
+في عندي normal morphology وفي عندي abnormal
+
+119
+00:09:40,810 --> 00:09:44,650
+morphology. الـabnormal morphology هي الـcytopathic
+
+120
+00:09:44,650 --> 00:09:47,990
+effect اللي احنا بنشوفه. إيش ممكن نشوف؟ ممكن نشوف
+
+121
+00:09:47,990 --> 00:09:52,430
+فجوات في النمو. بدل ما هي مونولية مغطية تماما نشوف
+
+122
+00:09:52,430 --> 00:09:57,990
+فجوات. ممكن نشوف خلايا بيسميها Multi-Nucleated
+
+123
+00:09:57,990 --> 00:10:03,350
+Giant Cell. إيش يعني Multi-Nucleated Giant Cell؟
+
+124
+00:10:03,350 --> 00:10:07,910
+خلية عملاقة. Multi-Nucleated يعني فيها العديد من
+
+125
+00:10:07,910 --> 00:10:12,130
+الأنوية. عبارة عن إيش هي دي؟ عبارة عن خلايا عادية. 
+
+126
+00:10:12,130 --> 00:10:17,370
+الفيروس لما عملها infection أزال الفواصل اللي بينها
+
+127
+00:10:17,370 --> 00:10:21,510
+فأصبحت وكأنها خلية كبيرة لكن الأنمي تبعتها ما
+
+128
+00:10:21,510 --> 00:10:26,370
+زالت موجودة هذا الفيروس كل مرة بيعمل نفس ال
+
+129
+00:10:26,370 --> 00:10:29,390
+infection بيعمل نفس ال cytopathic effect إذا
+
+130
+00:10:29,390 --> 00:10:34,370
+اتفقنا على أن ال cytopathic effect هو تأثير لبعض
+
+131
+00:10:34,370 --> 00:10:37,770
+الفيروسات، مش كل الفيروسات، لبعض الفيروسات على
+
+132
+00:10:37,770 --> 00:10:41,850
+الخلايا اللي بينمو عليها هذا الفيروس ومن خلالها
+
+133
+00:10:41,850 --> 00:10:45,370
+نستطيع التعرف على مين على الفيروسات، أعطيكم مثال
+
+134
+00:10:45,370 --> 00:10:53,590
+صغير، في فيروس اسمه Respiratory Syncytial Virus RSV
+
+135
+00:10:53,590 --> 00:10:58,410
+Respiratory Syncytial Virus، كلمة Syncytia تجمية
+
+136
+00:10:58,410 --> 00:11:03,030
+فهو بيروح... الخلايا بتكون خلايا normal morphology
+
+137
+00:11:03,030 --> 00:11:07,790
+بيروح بيجمعها مع بعض، كل مرة بشوف هذا التجميع بقول
+
+138
+00:11:07,790 --> 00:11:13,090
+أن الفيروس اسمه RSV، في فيروس ثاني اسمه
+
+139
+00:11:13,090 --> 00:11:16,510
+cytomegalovirus لما بيعمل infection للخلايا
+
+140
+00:11:16,510 --> 00:11:22,730
+الخلايا نفسها بيصير تحتوي على نواتين شكل عينتين
+
+141
+00:11:22,730 --> 00:11:27,730
+تحت الميكروسكوب، بنسميهم owl's eye، عارفين شنهو owl؟
+
+142
+00:11:27,730 --> 00:11:33,370
+البومة زي عينين البومة؟ تمام؟ هذا شكل مميز ومميز
+
+143
+00:11:33,370 --> 00:11:37,390
+للـ cytomegalovirus، إيه ثاني الـ cytopathic effect
+
+144
+00:11:37,390 --> 00:11:40,730
+هو أحد الوسائل اللي من خلالها ممكن نتعرف على مين
+
+145
+00:11:40,730 --> 00:11:43,980
+يا بنات؟ على الفيروسات طبعا، مش على كل الفيروسات لأن
+
+146
+00:11:43,980 --> 00:11:49,620
+مش كل الفيروسات أصلا بتعمل cytopathic effect، طيب
+
+147
+00:11:49,620 --> 00:11:53,400
+نيجي الآن لل specific events during the growth
+
+148
+00:11:53,400 --> 00:11:56,480
+cycle، و أنا ممكن كررتهم مرتين من أول المحاضرة
+
+149
+00:11:56,480 --> 00:12:00,660
+وسأكررهم للمرة الثالثة والرابعة أو الخامسة عشان نطلع
+
+150
+00:12:00,660 --> 00:12:05,810
+من المحاضرة إن شاء الله حافظينهم غيبا، attachment
+
+151
+00:12:05,810 --> 00:12:10,350
+and penetration of parental virus، ال parental يعني
+
+152
+00:12:10,350 --> 00:12:12,490
+الفيروس الأب اللي هو ال original الفيروس ال
+
+153
+00:12:12,490 --> 00:12:17,730
+original، attachment وبعدين إيش penetration، خدوا
+
+154
+00:12:17,730 --> 00:12:23,610
+بالكوا أنا بتكلم عن specific events لكل الفيروسات
+
+155
+00:12:23,610 --> 00:12:28,270
+لكن لما يدخلوا في التفاصيل هتلاقوا إنه ال attachment
+
+156
+00:12:28,270 --> 00:12:33,120
+من فيروس لفيروس بتختلف، الـ penetration من فيروس
+
+157
+00:12:33,120 --> 00:12:36,700
+لفيروس تختلف، يبقى... احنا بتكلم على إيه؟ على
+
+158
+00:12:36,700 --> 00:12:39,980
+specific event for the whole process for all
+
+159
+00:12:39,980 --> 00:12:44,140
+viruses، Uncoating of the viral genome، إيش يعني
+
+160
+00:12:44,140 --> 00:12:48,700
+uncoating؟ فصل المادة الوراثية عن الكبسيد وإذا كان
+
+161
+00:12:48,700 --> 00:12:54,180
+فيه أصلا coat، عفوا، envelope عشان نحرر المادة
+
+162
+00:12:54,180 --> 00:13:01,380
+الوراثية، Early viral mRNA synthesis، ليش بنعمل الـ
+
+163
+00:13:01,380 --> 00:13:04,440
+mRNA synthesis؟ عشان نطلع البروتين، عشان نطلع
+
+164
+00:13:04,440 --> 00:13:10,960
+البروتين، شوفوا عليا، لو أنا بدي أحاول أبني بيت،
+
+165
+00:13:10,960 --> 00:13:17,160
+قبل ما أبني البيت، بدي أجيب من؟ الأدوات، الأدوات
+
+166
+00:13:17,160 --> 00:13:21,580
+اللي بدي أصنع فيها هذا البيت، فالـ Early الـ Early
+
+167
+00:13:22,560 --> 00:13:27,220
+mRNA و early protein في الغالب يا بنات هي لتصنيع
+
+168
+00:13:27,220 --> 00:13:33,140
+الانزيمات اللازمة لتصنيع الفيروس في الآخر، يبقى هي
+
+169
+00:13:33,140 --> 00:13:38,120
+مرحلة تحضيرية للفيروس، في النصف في عندنا حاجة اسمها
+
+170
+00:13:38,120 --> 00:13:41,060
+viral genome replication، والمسؤول عن ال genome
+
+171
+00:13:41,060 --> 00:13:46,100
+viral replication هم الـ early protein أصلا بعد ما
+
+172
+00:13:46,100 --> 00:13:52,430
+صنعنا المادة الوراثية الأساسية للفيروس، تمام، نبدأ
+
+173
+00:13:52,430 --> 00:13:57,190
+الآن نصنع الـ Late mRNA والـ Late Protein، إيش هما
+
+174
+00:13:57,190 --> 00:14:00,090
+ال Late mRNA وال Late Protein؟ هما البروتينات
+
+175
+00:14:00,090 --> 00:14:06,090
+اللازمة لبناء الفيروس زي مثلا الـ Capsomers، تمام؟
+
+176
+00:14:06,090 --> 00:14:09,390
+إذا كان بدنا جينوم، إذا كان بدنا enzymes معينة
+
+177
+00:14:09,390 --> 00:14:13,890
+ناخدها معانا على الخلايا الأخرى، هذه كلها بتتم في
+
+178
+00:14:13,890 --> 00:14:18,430
+مرحلة مين؟ ال Late mRNA وال Late Protein Synthesis
+
+179
+00:14:19,070 --> 00:14:23,690
+بعدين صار عندي الآن مادة وراثية، صار عندي وحدات
+
+180
+00:14:23,690 --> 00:14:29,770
+بنائية، العملية التالية هي التجميع، حط ال DNA جوا ال
+
+181
+00:14:29,770 --> 00:14:33,770
+capsid، حط ال DNA جوا ال capsid، المحاضرة اللي فاتت
+
+182
+00:14:33,770 --> 00:14:37,530
+لما كلمنا عن ال pseudo virion لما قلنالكوا بعض
+
+183
+00:14:37,530 --> 00:14:42,750
+الأحيان الفيروسات بتخطأ و بتحط مادة وراثية، هذا متى
+
+184
+00:14:42,750 --> 00:14:46,230
+بتتم في عملية ال assembly، اللي المرحلة اللي قبل
+
+185
+00:14:46,230 --> 00:14:50,670
+الأخرى، طب بعد ما عملنا assembly إيش دلوقتي للفيروس؟
+
+186
+00:14:50,670 --> 00:14:58,010
+لازم إيش يعمل الآن؟ ينطلق، release، بتحرر، بعض
+
+187
+00:14:58,010 --> 00:15:02,710
+الفيروسات بتتحرر بإنها بتحلل الخلية، وبعض
+
+188
+00:15:02,710 --> 00:15:05,590
+الفيروسات، وهذا على فكرة بتعمل cytopathic effect
+
+189
+00:15:05,590 --> 00:15:09,390
+لإنها بتدمر الخلية، وبعض الفيروسات بتطلع بأدب،
+
+190
+00:15:09,390 --> 00:15:12,720
+واحد واحد، بيطلع بياخد معاها قطعة من ال cell
+
+191
+00:15:12,720 --> 00:15:15,960
+membrane و بيلزق ال cell membrane وراها فبتضل
+
+192
+00:15:15,960 --> 00:15:21,600
+الخلية وكأنها ما فيها أي ضرر، وبيطلع الفيروسات
+
+193
+00:15:21,600 --> 00:15:26,140
+تباعا منها وما بيصيرش فيها cytopathic effect، يعرفنا
+
+194
+00:15:26,140 --> 00:15:30,440
+من وين بيجي الـ cytopathic effect؟ من تكاثر الفيروس أو
+
+195
+00:15:30,440 --> 00:15:33,960
+من إطلاق الفيروس اللي هو ال release تبع هذا
+
+196
+00:15:33,960 --> 00:15:42,220
+الفيروس، الشكل اللي أمامنا لابد من تطبيق ما ذكرناه
+
+197
+00:15:42,220 --> 00:15:47,140
+من events على هذا الشكل، واللوحة اللي أمامكم هي
+
+198
+00:15:47,140 --> 00:15:53,280
+عبارة عن التكاثر في ال adenovirus، واحد من أكثر
+
+199
+00:15:53,280 --> 00:15:57,580
+الفيروسات اللي درست فيها ال replication cycle
+
+200
+00:15:58,110 --> 00:16:01,290
+والعملية السهلة هي ال adenovirus اللي هو اللي
+
+201
+00:16:01,290 --> 00:16:05,390
+ممثله بإنها e-causa، هيدرال الخلية اللي أمامنا هذه
+
+202
+00:16:05,390 --> 00:16:11,110
+أمثلة على أنها host cell، هذا cytoplasm وهذه
+
+203
+00:16:11,110 --> 00:16:16,350
+الكبيرة النواة، ليش هو كبر النواة مع أنها مش هالجد
+
+204
+00:16:16,350 --> 00:16:21,470
+حجمها؟ عشان الرسمة، عشان هذا الفيروس جزء من جزء كبير
+
+205
+00:16:21,470 --> 00:16:26,130
+من الأنشطة، طبعته بتتم في وين؟ في النواة، وهذه نقطة
+
+206
+00:16:26,130 --> 00:16:30,570
+بدنا ننتبه لها من الآن، إن كثير من الفيروسات تتكاثر
+
+207
+00:16:30,570 --> 00:16:35,970
+تماما في الـ cytoplasm، بتروح لمين؟ على النواة، وفي
+
+208
+00:16:35,970 --> 00:16:41,050
+في فيروسات لابد من أن تذهب إلى النواة، إذا بيختلفوا
+
+209
+00:16:41,050 --> 00:16:44,940
+عن بعض في هذا الجزء، Attachment, Penetration,
+
+210
+00:16:46,100 --> 00:16:50,140
+Uncoating، وين المادة دلوقتي؟ راحت على النواة، Early
+
+211
+00:16:50,140 --> 00:16:53,680
+transcription, Early translation, Synthesis للـ
+
+212
+00:16:53,680 --> 00:16:57,260
+Early protein اللي هي ال enzymes زي ال DNA
+
+213
+00:16:57,260 --> 00:17:00,640
+polymerases وكانت هاي أدوات اللي بنستخدمها في
+
+214
+00:17:00,640 --> 00:17:04,120
+التصنيع، بعدين في عندي هنا اللي هو ال synthesis
+
+215
+00:17:04,120 --> 00:17:09,880
+للمادة الوراثية، تمام، اللي هي للفيروس نفسه، بعدين ال
+
+216
+00:17:09,880 --> 00:17:14,300
+mRNA و ال protein ال late، بعد هيك assembly، لاحظوا
+
+217
+00:17:14,300 --> 00:17:20,060
+الآن إيش صار عندي؟ فيروس كامل داخله مادة وراثية، و
+
+218
+00:17:20,060 --> 00:17:24,960
+بعدين release، إذا الخطوات اللي ذكرناهم إن أدهم مع
+
+219
+00:17:24,960 --> 00:17:27,300
+بعض، أنا بدي أدهم وشوفوا حالكوا حافظوا إن هم ولا
+
+220
+00:17:27,300 --> 00:17:30,700
+لأ، attachment penetration 
+
+221
+00:17:32,670 --> 00:17:37,470
+uncoating، early mRNA synthesis، late mRNA
+
+222
+00:17:37,470 --> 00:17:43,110
+synthesis، في النص اللي هو ال genome replication،
+
+223
+00:17:43,110 --> 00:17:47,590
+بعدين late protein، عفوا، late mRNA synthesis،
+
+224
+00:17:47,590 --> 00:17:52,010
+late protein synthesis assembly and release، هاي
+
+225
+00:17:52,010 --> 00:17:56,850
+عشر خطوات كاملين بيوضحون لنا ل specific events لـ any
+
+226
+00:17:56,850 --> 00:18:02,550
+virus أو any viral replication، نبدأ بالخطوة الأولى
+
+227
+00:18:02,550 --> 00:18:06,430
+احنا قلنا إن هذه معلومات عامة، الآن نتكلم عن بعض
+
+228
+00:18:06,430 --> 00:18:11,330
+التفاصيل، attachment والـ attachment لا تتم يا بنات
+
+229
+00:18:11,330 --> 00:18:16,150
+إلا من خلال receptors، وهذا على فكرة بيثير سؤال
+
+230
+00:18:16,150 --> 00:18:19,610
+كثير، بيسألون الطلبة، طب هو احنا يا دكتور مصممين
+
+231
+00:18:19,610 --> 00:18:23,750
+أصلا ال receptors تبعتنا، يعني خليانا مصممة عشان
+
+232
+00:18:23,750 --> 00:18:30,120
+تنصب الفيروس، إيش رأيكم؟ مدام... مدام الارتباط هو
+
+233
+00:18:30,120 --> 00:18:35,860
+أصلا من خلال receptors، ال
+
+234
+00:18:35,860 --> 00:18:39,020
+... ال... ال receptor احنا... احنا المستقبلين ال
+
+235
+00:18:39,020 --> 00:18:42,820
+antigen اللي بده يرتبط معانا، تمام، احنا receptor هو
+
+236
+00:18:42,820 --> 00:18:47,560
+antigen، فهل هو احنا مصممين أن يكون عندنا receptors
+
+237
+00:18:47,560 --> 00:18:49,540
+لهذه ال antigen؟  أنا السؤال
+
+238
+00:18:54,000 --> 00:18:59,920
+الريسبتور ليس ضعف، وليس ضعف، هو مركب موجود على
+
+239
+00:18:59,920 --> 00:19:02,960
+الخلايا تبعتنا، الجواب
+
+240
+00:19:04,420 --> 00:19:09,000
+الفيروسات بتستغل receptors normally have functions
+
+241
+00:19:09,000 --> 00:19:12,660
+in our body، يعني في الهواء ضائف في أجسامنا
+
+242
+00:19:12,660 --> 00:19:16,280
+بتستغلها هذه الفيروسات، مثلا ناخد أصل اللوحة اللي
+
+243
+00:19:16,280 --> 00:19:19,820
+بعديها على السرية، وبيبّن أنه جال اللوحة هذه كلكوا
+
+244
+00:19:19,820 --> 00:19:23,960
+بتعرفوا أن ال CD4 هو موجود على ال T-Helper cells
+
+245
+00:19:25,010 --> 00:19:29,770
+والـ T-Helper Cells تستخدمه للارتباط بـ Class II
+
+246
+00:19:29,770 --> 00:19:33,110
+MHC اللي هو الـ Major Histocompatibility Complex
+
+247
+00:19:33,110 --> 00:19:38,350
+عشان تعمل activation للـ Helper T Cell، يعني في الـ
+
+248
+00:19:38,350 --> 00:19:42,170
+CD4 هذا اللي ماله؟ له Normal Function، مين اللي
+
+249
+00:19:42,170 --> 00:19:50,270
+بيرتبط فيه؟ الـ HIV، الـ HIV استغل الـ CD4 ريسبتور
+
+250
+00:19:50,270 --> 00:19:54,350
+تمام في الارتباط، لكن CD4 لها normal function عندنا
+
+251
+00:19:54,350 --> 00:19:59,650
+ناخد مثال تاني الـ Rabies اللي هو ده السعر أو
+
+252
+00:19:59,650 --> 00:20:05,090
+الفيروس ده السعر أو الكلب بيرتبط بالـ Acetylcholine 
+
+253
+00:20:05,090 --> 00:20:08,550
+ريسبتور، مين ما عندهوش فينا Acetylcholine ريسبتور؟
+
+254
+00:20:08,550 --> 00:20:12,410
+كلنا عندنا .. أقولكوا كل الثدييات لديها
+
+255
+00:20:12,410 --> 00:20:17,150
+Acetylcholine وبالتالي هذا الفيروس يصيب كل
+
+256
+00:20:17,150 --> 00:20:21,570
+الثدييات، طب الـ Acetylcholine هو أصلا نيوترانسميتر
+
+257
+00:20:21,570 --> 00:20:24,630
+وبالتالي لازم يكون فيه أنه ريسبتور، الـ Rabies
+
+258
+00:20:24,630 --> 00:20:27,910
+استغل هذا الريسبتور في الارتباط، فإن الـ Epstein
+
+259
+00:20:27,910 --> 00:20:31,230
+-Barr أو الـ EB Virus بيرتبط بالكمبلمنت
+
+260
+00:20:31,230 --> 00:20:33,590
+ريسبتور، والكمبلمنت يوزع من our immune system
+
+261
+00:20:33,590 --> 00:20:37,330
+وبالتالي بالفعل لازم يكون موجود الـ Vaccinia Virus
+
+262
+00:20:37,330 --> 00:20:40,310
+بيرتبط بالـ Epidermal Growth Factor وهذا أيضًا
+
+263
+00:20:40,310 --> 00:20:45,510
+فاكتور مهم إلينا، والأصل إنه يكون موجود لكن الـ
+
+264
+00:20:45,510 --> 00:20:48,170
+Virus أو الـ Vaccinia Virus بيرتبط فيه الـ
+
+265
+00:20:48,170 --> 00:20:52,690
+Rhinovirus، الفيروس الرشح بيرتبط في الـ Receptor
+
+266
+00:20:52,690 --> 00:20:56,710
+بيسموه ICAM-1 أو Intracellular Adhesion Molecule-1
+
+267
+00:20:56,710 --> 00:20:59,590
+وهذا أيضًا من الـ Receptors اللي المفروض تكون
+
+268
+00:20:59,590 --> 00:21:02,390
+موجودة في الإنسان ويقولها Normal Function إذن
+
+269
+00:21:02,390 --> 00:21:08,220
+الفيروسات ترتبط بالريسيبتورز normally لها Normal
+
+270
+00:21:08,220 --> 00:21:10,900
+Function عند الإنسان، نرجع برجوع على اللوحة اللي
+
+271
+00:21:10,900 --> 00:21:19,220
+قبلها نقول إنه طالما أن الـ Attachment Specific
+
+272
+00:21:19,220 --> 00:21:23,680
+يبقى هي المسؤولة عن الـ Species الـ Specificity و الـ
+
+273
+00:21:23,680 --> 00:21:27,700
+Host Range، إيش يعني Host Range فاكرين في البكتيريا
+
+274
+00:21:27,700 --> 00:21:31,440
+كنا نتكلم عن أختين سلمونيلا وشيجلا كنا نقول
+
+275
+00:21:31,440 --> 00:21:37,100
+السلمونيلا بتصيب السحالي بتصيب الحرادين بتصيب
+
+276
+00:21:37,100 --> 00:21:41,580
+التنمساح بتصيب الدواجن بتصيب البنات من؟ إلها Host
+
+277
+00:21:41,580 --> 00:21:47,240
+Range واسعة بينما الشيء اللي لا تصيب إلا الإنسان
+
+278
+00:21:47,240 --> 00:21:53,670
+Host Range ضيق، في الفيروسات كذلك الأمر في منها ما هو
+
+279
+00:21:53,670 --> 00:21:58,450
+Wide أو الـ Host Range واسع وفي منها الـ Host Range
+
+280
+00:21:58,450 --> 00:22:03,050
+ضيق مثل الـ Poliovirus الـ Polio اللي هو مرض شلل
+
+281
+00:22:03,050 --> 00:22:08,890
+الأطفال أو فيروس شلل الأطفال يصيب فقط الإنسان و الـ
+
+282
+00:22:08,890 --> 00:22:11,570
+Primates الـ Primates اللي هم زي القردة ده الـ
+
+283
+00:22:11,570 --> 00:22:16,690
+Gorilla و الشمبانزي بينما الـ Rabies Virus اللي احنا
+
+284
+00:22:16,690 --> 00:22:20,890
+ذكرناه قبل قليل، فاكرين الـ Rabies بيصيب بأي ريسبتور
+
+285
+00:22:20,890 --> 00:22:25,770
+الـ Acetylcholine وقلنالكوا الـ Acetylcholine موجود في
+
+286
+00:22:25,770 --> 00:22:28,970
+كل الـ Mammals وبتالي طالع هو اللي بيصيب هنا بيصيب
+
+287
+00:22:28,970 --> 00:22:33,550
+كل الـ Mammalian Cells، إذن الـ Rabies Virus Wide
+
+288
+00:22:33,550 --> 00:22:37,770
+Range الـ Host Wide Range بينما الـ الـ الـ الـ
+
+289
+00:22:37,770 --> 00:22:41,210
+Poliovirus Narrow Range، مين المسؤول عن الكلام هذا؟
+
+290
+00:22:42,910 --> 00:22:46,130
+وجود Receptor والدليل على ذلك إنه احنا بنتكلم على
+
+291
+00:22:46,130 --> 00:22:50,670
+أن الارتباط Specific ومدام Specific فهو الذي
+
+292
+00:22:50,670 --> 00:22:55,950
+سيحدد الـ Host وهو الذي سيحدد الـ Organ وهذا الكلام
+
+293
+00:22:55,950 --> 00:22:59,530
+حكيناه من أول محاضرة لما قلنالكوا Species and
+
+294
+00:22:59,530 --> 00:23:05,050
+Organ Specificity are determined by the Proteins
+
+295
+00:23:05,050 --> 00:23:09,050
+الـ Outer Proteins أما على الـ Envelope أو على الـ
+
+296
+00:23:09,050 --> 00:23:11,050
+Capsid في حال عدم وجود Envelope
+
+297
+00:23:13,870 --> 00:23:19,150
+الـ Penetration كلمة Penetration يعني هو التثقّب وهو
+
+298
+00:23:19,150 --> 00:23:22,450
+خطوة أولى، كويس إنه التثقّب و Specific Receptor و Non
+
+299
+00:23:22,450 --> 00:23:26,190
+-Covalent Bonding وغالبا الـ Bond بتكون Weak Bond
+
+300
+00:23:26,190 --> 00:23:31,150
+يعني رابطة ضعيفة، لحظة في الـ Penetration ممكن يكون
+
+301
+00:23:31,150 --> 00:23:36,210
+Fusion with Host Cell Membrane لما كان الـ Virus
+
+302
+00:23:36,210 --> 00:23:42,420
+Envelope وهذا التثقّب بالخلية هاي الـ Virus هذه
+
+303
+00:23:42,420 --> 00:23:49,700
+الخلية وهذا الفيروس الآن، الفيروس يمتلك ممبرين من
+
+304
+00:23:49,700 --> 00:23:56,150
+جنس الممبرين تبع الـ Host وإذا بتذكروا لما شرحنالكوا
+
+305
+00:23:56,150 --> 00:24:00,610
+الـ Membrane قولنالكوا هو عبارة عن Viscous مش حاجة
+
+306
+00:24:00,610 --> 00:24:04,810
+صلبة يعني سهل جدا إنه يمتزج الـ Viscous مع الـ
+
+307
+00:24:04,810 --> 00:24:07,570
+Viscous وبالتالي الـ Membrane مع الـ Membrane
+
+308
+00:24:07,570 --> 00:24:13,900
+هيمتزجوا مع بعض والفيروس هيخترق الخلية، هذا من خلال
+
+309
+00:24:13,900 --> 00:24:18,620
+مين؟ Fusion with the Whole Cell Membrane في طريقة
+
+310
+00:24:18,620 --> 00:24:22,480
+تانية زي اللي احنا شايفينها هنا اسمها Endocytosis
+
+311
+00:24:22,480 --> 00:24:27,140
+أو Pinocytosis مش Phagocytosis وإنما Endocytosis
+
+312
+00:24:27,140 --> 00:24:32,480
+تمام؟ والطريقتين موجودة، شوفوا الـ Membrane هنا لما
+
+313
+00:24:32,480 --> 00:24:37,730
+صار Fusion بين الـ Outer Membrane وبين الـ Cell
+
+314
+00:24:37,730 --> 00:24:41,750
+Membrane تبع الـ Host Cell والفيروس دخل إلى الداخل
+
+315
+00:24:41,750 --> 00:24:46,210
+لكن هنا دخل الفيروس من خلال إيه يا شباب؟ من خلال
+
+316
+00:24:46,210 --> 00:24:52,530
+Physical، إيش يعني Physical؟ هوى صلاة دخل جواها
+
+317
+00:24:52,530 --> 00:24:58,170
+الفيروس إلى داخل الخلية وبعدين بيمر بعملية بنسميها
+
+318
+00:24:58,170 --> 00:25:02,190
+اللي هي الـ Uncoating والـ Uncoating هنشوف كمان شوية
+
+319
+00:25:02,190 --> 00:25:08,630
+أنه الـ Physical هذه ذكية، هذه Physical ذكية لأنه
+
+320
+00:25:08,630 --> 00:25:14,170
+بتحاول إنها تعمل الـ pH يكون ملائم للـ Uncoating
+
+321
+00:25:14,170 --> 00:25:19,310
+لمين؟ لـ .. اللي هو الـ Virus Itself، كدا اتفقنا إنه
+
+322
+00:25:19,310 --> 00:25:24,550
+دخول الـ Virus إما بيكون عبر Fusion، الاتحام مع الـ
+
+323
+00:25:24,550 --> 00:25:27,250
+Cell Membrane أو عن طريق الـ Endocytosis
+
+324
+00:25:29,260 --> 00:25:33,940
+الـ Uncoating قلنا هو عبارة عن Rupture أو انفجار of
+
+325
+00:25:33,940 --> 00:25:36,840
+the Vesicle أو Fusion of the Outer Layer of the
+
+326
+00:25:36,840 --> 00:25:39,560
+Virus with the Vesicle Membrane Deposits the Inner
+
+327
+00:25:39,560 --> 00:25:43,360
+Core، المحصلة النهائية للـ Uncoating إنه المادة
+
+328
+00:25:43,360 --> 00:25:47,520
+الوراثية هتخرج من مين؟ من الـ .. الـ .. الـ .. الـ
+
+329
+00:25:47,520 --> 00:25:52,120
+Capsid تبعت الفيروس، وقلنا أن الـ Low pH الـ .. الـ pH
+
+330
+00:25:52,120 --> 00:25:56,520
+المنخفض الحامضي في الـ Vesicle بيـ .. بيـ .. بيساعد
+
+331
+00:25:56,520 --> 00:25:58,500
+على اللي هو الـ Uncoating
+
+332
+00:26:04,260 --> 00:26:08,500
+التلات خطوات اللي ذكرناهم Attachment Penetration
+
+333
+00:26:08,500 --> 00:26:14,620
+Uncoating هم تلات Events ماشيين مع بعض يعني غالبا
+
+334
+00:26:14,620 --> 00:26:17,900
+بيصير فيه ارتباط وبعدين دخول وبعدين اللي هو
+
+335
+00:26:17,900 --> 00:26:22,520
+Uncoating فبنلاقي عند حاجة غريبة مختلفة شوية عما
+
+336
+00:26:22,520 --> 00:26:27,580
+درسناها في الخطوات السابقة، متعلق ببعض الفيروسات
+
+337
+00:26:27,580 --> 00:26:29,300
+اللي هي مرتبطة بالبكتيريا اللي بيسميها
+
+338
+00:26:29,300 --> 00:26:35,730
+Bacteriophages، البكتيريوفاج لا بيصير له Fusion ولا
+
+339
+00:26:35,730 --> 00:26:40,110
+بيصير له Endocytosis، طب هاي إيش بيعمل؟ طريقة تالتة
+
+340
+00:26:40,110 --> 00:26:45,230
+الطريقة التالتة إنه الفيروس نفسه بيجئ على الخلية
+
+341
+00:26:45,230 --> 00:26:52,750
+من برا وبيحقن المادة الوراثية من خلال إحداث ثقب في
+
+342
+00:26:52,750 --> 00:26:56,950
+الـ Cell Wall تبع البكتيريا من خلال إنزيم اسمه
+
+343
+00:26:56,950 --> 00:26:58,930
+Lysozyme
+
+344
+00:27:00,390 --> 00:27:04,370
+الـ Tail Fiber تبعته هي الـ Receptor وفيه قرص Disk
+
+345
+00:27:04,370 --> 00:27:09,310
+لما بيجي على البكتيريا من الـ Disk بينزل الإنزيم،
+
+346
+00:27:09,310 --> 00:27:14,130
+الإنزيم بيدوب أو بيذيب اللي هو الـ Cell Wall
+
+347
+00:27:14,130 --> 00:27:19,150
+وبيبدأ بعملية Contraction للـ Tail Fiber أو عفوا
+
+348
+00:27:19,150 --> 00:27:24,460
+للـ Collar تبعته، فبيجيب الـ DNA تبعه من رأسه اللي هو
+
+349
+00:27:24,460 --> 00:27:28,160
+من الرأس تبع الـ .. الـ .. الـ .. وبيحقنه داخل اللي
+
+350
+00:27:28,160 --> 00:27:32,780
+هو كـ Injection بالظبط كحقنة بيحقن الـ DNA لداخل
+
+351
+00:27:32,780 --> 00:27:36,680
+اللي هو الـ Bacteria، إذا الـ Bacteriophage مختلفة
+
+352
+00:27:36,680 --> 00:27:41,080
+شوية عن مين؟ عن الـ Other الـ Animal Virus وهذه ممكن
+
+353
+00:27:41,080 --> 00:27:44,440
+صورة كرتونية وهتاخد وقت شوية لما تشتغل لكن هذا هو
+
+354
+00:27:44,440 --> 00:27:47,260
+الـ Bacteriophage، فرصة نتكلم عنه، هذا الرأس هذا
+
+355
+00:27:47,260 --> 00:27:52,470
+المادة الوراثية، هذا اللي كان الآن، الالتقاء لحظة لما
+
+356
+00:27:52,470 --> 00:27:56,170
+بيلتقي مع الـ Receptors بينزل هذا الـ Disk بيحلل
+
+357
+00:27:56,170 --> 00:28:00,350
+اللي هو الـ Cell Wall وبيبدأ يحقن من المادة
+
+358
+00:28:00,350 --> 00:28:03,530
+الوراثية، طبعا هذه الصورة بتوضح كل الخطوات تبع الـ
+
+359
+00:28:03,530 --> 00:28:07,590
+الـ الـ Replication بس أنا معني فقط بالـ .. بالـ ..
+
+360
+00:28:07,590 --> 00:28:12,360
+بالـ .. بالجزء المتعلق بمين؟ بإدخال المادة الوراثية
+
+361
+00:28:12,360 --> 00:28:16,680
+لأنه مختلف تماما عن الـ Animal Virus لم يكن هناك
+
+362
+00:28:16,680 --> 00:28:22,180
+حاجة للفيروس أن يدخل إلى داخل الخلية وإنما أدخل من
+
+363
+00:28:22,180 --> 00:28:27,960
+المادة الوراثية وبقي هو كصدفة فارغة لا تحتوي على
+
+364
+00:28:27,960 --> 00:28:30,920
+شيء يعني ميت مائل وأي قيمة في الخارج
+
+365
+00:28:36,370 --> 00:28:40,850
+إذن نسترجع مع بعض وين وصلنا؟ وصلنا للـ Attachment
+
+366
+00:28:40,850 --> 00:28:44,130
+و الـ Penetration و الـ Uncoating الآن بدنا ننتقل
+
+367
+00:28:44,130 --> 00:28:48,250
+أكيد لمرحلة اللي هو الـ Early Viral mRNA Synthesis
+
+368
+00:28:48,250 --> 00:28:52,470
+و الـ Early Viral Protein Synthesis Gene
+
+369
+00:28:52,470 --> 00:28:55,970
+Expression and Genome Replication كلمة Gene
+
+370
+00:28:55,970 --> 00:29:02,970
+Expression ماذا تعني؟ أن الجين يعبر عنه بالبروتين
+
+371
+00:29:02,970 --> 00:29:08,610
+من خلال ترجمة من خلال الـ Transcription لـ mRNA ومن
+
+372
+00:29:08,610 --> 00:29:13,050
+ثم إلى البروتين إذا الجين اللي هو الـ DNA يتحول إلى
+
+373
+00:29:13,050 --> 00:29:17,990
+mRNA ثم يتحول إلى البروتين، إذا تحول لبروتين بنقول
+
+374
+00:29:17,990 --> 00:29:25,240
+تم التعبير عن الجين، لما بنقول Genome Replication،
+
+375
+00:29:25,240 --> 00:29:30,040
+المادة الوراثية الأصلية تتكاثر، 
+
+376
+00:29:30,040 --> 00:29:34,140
+تنقسم، يعني بدل ما كان نسخة واحدة، صار عندي مئات
+
+377
+00:29:34,140 --> 00:29:39,040
+نسخ تمهيدا لتعبيئتها في الكبسيط، إذا في اختلاف بين
+
+378
+00:29:39,040 --> 00:29:44,780
+gene expression وبين genome replication. The first
+
+379
+00:29:44,780 --> 00:29:48,760
+step in viral gene expression is mRNA synthesis.
+
+380
+00:29:49,470 --> 00:29:52,750
+وهذا كلام معروف، إذا بتعبر عن الـG لازم يطلع عندنا
+
+381
+00:29:52,750 --> 00:29:57,770
+mRNA، طب إذا كان الجينوم هو نفسه mRNA، مش إحنا كنا 
+
+382
+00:29:57,770 --> 00:30:03,770
+فيه فيروسات، المادة الوراثية تبعتها هي RNA، إيه
+
+383
+00:30:03,770 --> 00:30:10,460
+بتصير؟ هذا عشان... عشان نصنع منها اللي هي الـ genome 
+
+384
+00:30:10,460 --> 00:30:15,040
+تبعها بس عشان نعملها expression في بعض... في بعض
+
+385
+00:30:15,040 --> 00:30:21,080
+الفيروسات المادة الوراثية نفسها بتكون هي ال... ال
+
+386
+00:30:21,080 --> 00:30:25,580
+... النسخة اللي بنشتغل عليها translation يعني على
+
+387
+00:30:25,580 --> 00:30:31,010
+طول بنترجمها لمين؟ ل... لـ protein. لكن بشكل عام إذا
+
+388
+00:30:31,010 --> 00:30:33,810
+ما نتحدث عن الفيروسات مش كلها بشكل عام نقول إنه
+
+389
+00:30:33,810 --> 00:30:37,830
+هذه العملية بتعتمد على شغلتين أساسيتين the nature
+
+390
+00:30:37,830 --> 00:30:41,590
+of their nucleic acid. the part of the cell in
+
+391
+00:30:41,590 --> 00:30:46,210
+which they replicate. هل بتكاثروا في النواة ولا في
+
+392
+00:30:46,210 --> 00:30:50,890
+الـ cytoplasm؟ وما هي المادة الوراثية؟ هل هي DNA ولا
+
+393
+00:30:50,890 --> 00:30:56,770
+RNA؟ وطبعا كمان مرة هلاجي تفاصيل عميقة جدا في
+
+394
+00:30:56,770 --> 00:31:02,380
+موضوع المادة الوراثية. أنا متعود أفهم... أقرأ إن الـ
+
+395
+00:31:02,380 --> 00:31:08,780
+mRNA هو single-strand. أول كنت دراسته في التانوية
+
+396
+00:31:08,780 --> 00:31:11,940
+أو في سنة أولى أو سنة تانية في الجامعة إن الـ mRNA
+
+397
+00:31:11,940 --> 00:31:15,600
+double-stranded. اليوم هلاجي double strand. طب في
+
+398
+00:31:15,600 --> 00:31:19,920
+double strand هل هم واحد؟ لأ أكيد complementary
+
+399
+00:31:19,920 --> 00:31:24,900
+لبعض. واحد بيسميه بصي وواحد بيسميه negative و كيف
+
+400
+00:31:24,900 --> 00:31:28,120
+هذا بيشتغل و كيف هذا بيشتغل برضه كمان طريقة مختلفة
+
+401
+00:31:28,120 --> 00:31:33,460
+الحقيقة عن بعضهم البعض. طيب نطلع على اللوحة دي و
+
+402
+00:31:33,460 --> 00:31:38,040
+نركز كويس لما اتكلم على الـ DNA viruses و الـ RNA
+
+403
+00:31:38,040 --> 00:31:43,640
+viruses. نعمل محاولة تمهيد. العملية الـ replication في
+
+404
+00:31:43,640 --> 00:31:48,540
+اتنين. الـ DNA viruses consist of double-stranded
+
+405
+00:31:48,540 --> 00:31:54,340
+DNA except for the parvo virus which is a single
+
+406
+00:31:54,340 --> 00:31:59,580
+-stranded DNA. إذا كل الـ DNA viruses are double
+
+407
+00:31:59,580 --> 00:32:04,920
+-stranded ما عدا الـ parvo viruses عبارة عن single
+
+408
+00:32:04,920 --> 00:32:10,980
+-stranded DNA. ما أظن نتعامل معه كـ double-stranded
+
+409
+00:32:11,630 --> 00:32:16,190
+بينما الـ RNA viruses they consist of single
+
+410
+00:32:16,190 --> 00:32:20,670
+-stranded RNA except for the members of the reo
+
+411
+00:32:20,670 --> 00:32:25,170
+family which have double-stranded RNA. جينوم خدوا 
+
+412
+00:32:25,170 --> 00:32:29,710
+بالكوا الفروقات هذه كتير مهمة و الـ exceptions برضه
+
+413
+00:32:29,710 --> 00:32:33,750
+مهمة. يعني اللوحة هذه كويسة في الامتحان يعني ممكن
+
+414
+00:32:33,750 --> 00:32:38,630
+نجيب منها نص الامتحان من اللوحة دي. شو رأيكم؟ هي ريتها
+
+415
+00:32:38,630 --> 00:32:45,330
+هتحفظوها و خلاص أو تحطوها على الجوالة. طيب كمان مرة
+
+416
+00:32:45,330 --> 00:32:48,450
+كل الـ DNA viruses are double-stranded معادة الـ
+
+417
+00:32:48,450 --> 00:32:53,150
+Parvo virus و كل الـ RNA single-stranded معادة الـ
+
+418
+00:32:53,150 --> 00:32:56,390
+reo virus which have double-stranded RNA. الـ
+
+419
+00:32:56,390 --> 00:33:02,530
+Rotavirus أحد الأمثلة الشهيرة على الـ reo virus
+
+420
+00:33:02,530 --> 00:33:04,750
+family. إيش هو الـ Rotavirus؟
+
+421
+00:33:07,590 --> 00:33:12,290
+الروتا فيروس أحد مسببات الإسهال لدى الأطفال في
+
+422
+00:33:12,290 --> 00:33:17,050
+معظم أنحاء العالم. وحديثا في غزة أعتقد دخوله
+
+423
+00:33:17,050 --> 00:33:21,870
+vaccine. دخوله vaccine للروتا فيروس. طبعا الروتا
+
+424
+00:33:21,870 --> 00:33:24,950
+فيروس ما كانش معروف بالنسبة لنا في غزة أنا وجدش
+
+425
+00:33:24,950 --> 00:33:28,290
+نسابه غير كام من دراسة صارت في غزة من طلبة ماجستير
+
+426
+00:33:28,290 --> 00:33:33,710
+وبعضها أظهر أنه من عشرة لخمستاش بالمائة من حالات
+
+427
+00:33:33,710 --> 00:33:39,980
+الإسهال في الأطفال is caused by this virus. فهذا أو
+
+428
+00:33:39,980 --> 00:33:44,880
+هذه النتائج أدت إلى جعل من صناعة القرار يفكروا في واحد
+
+429
+00:33:44,880 --> 00:33:49,400
+إدخال فحوصات سيرولوجية للـ stool للروتا فيروس ويدعوهم
+
+430
+00:33:49,400 --> 00:33:53,260
+يفكروا في موضوع اللي هو الـ vaccine production. طيب
+
+431
+00:33:53,260 --> 00:33:58,840
+الـ DNA viruses they replicate in the nucleus. بتكتر
+
+432
+00:33:58,840 --> 00:34:02,320
+وين؟ وشوفنا الـ adenovirus جاب شوية الـ adenovirus
+
+433
+00:34:02,320 --> 00:34:07,620
+الرسوم تبعتنا شفناه وين؟ في الـ nucleus and uses the
+
+434
+00:34:07,620 --> 00:34:11,380
+host DNA dependent RNA polymerase to synthesize
+
+435
+00:34:11,380 --> 00:34:12,340
+their mRNA.
+
+436
+00:34:18,580 --> 00:34:23,740
+ومنها مين الـ DNA dependent RNA لعملية الـ synthesis
+
+437
+00:34:23,740 --> 00:34:29,420
+للـ MRNA. يعني بيجيبوش معاهم specific enzymes لأ
+
+438
+00:34:29,420 --> 00:34:34,820
+بيستغلوا الـ enzymes اللي موجودة. مثال على exception
+
+439
+00:34:34,820 --> 00:34:39,520
+إحنا قولنا كويس و اين بتكلمت على همها؟ في الـ
+
+440
+00:34:39,520 --> 00:34:43,080
+nucleus. الـ parvo viruses هم الـ exception لأنهم
+
+441
+00:34:43,080 --> 00:34:47,480
+يتعاملون في الـ cytoplasm. فيش شيء كله كامل و أنا
+
+442
+00:34:47,480 --> 00:34:50,680
+قلتلكم من البداية اللي يدرس معانا micro لازم يكون
+
+443
+00:34:50,680 --> 00:34:57,440
+مستعد لمين؟ للاستثناءات. و الاستثناءات هيقد تكون
+
+444
+00:34:57,440 --> 00:35:04,020
+صعبة عند البعض، لكن قد تكون فرصة لمعرفة أو تمييز
+
+445
+00:35:04,020 --> 00:35:08,540
+بعض الفيروسات عن بعضها البعض من خلال هذا الاستثناء
+
+446
+00:35:08,540 --> 00:35:11,920
+اللي إحنا بنتكلم عنه، إذن الـ parvo virus هو الوحيد
+
+447
+00:35:11,920 --> 00:35:15,640
+من الـ DNA فيروس اللي بتكاثر وين؟ في الـ cytoplasm،
+
+448
+00:35:15,640 --> 00:35:22,620
+كلهم بتكاثر في الـ nucleus where they do not have
+
+449
+00:35:22,620 --> 00:35:27,350
+access to the host's RNA polymerase. طبعا كونها مردف
+
+450
+00:35:27,350 --> 00:35:31,350
+أنه يبقى لام تستطيع الحصول على مين؟ على الـ DNA
+
+451
+00:35:31,350 --> 00:35:35,130
+dependent RNA polymerase تبع الخلية، فمضطرة هذه
+
+452
+00:35:35,130 --> 00:35:40,630
+الفيروسات أن تجيب معاها their own polymerase. وصل
+
+453
+00:35:40,630 --> 00:35:44,390
+الصورة و تذكروا الكلام كويس لإنه هيلزمنا كمان شوية
+
+454
+00:35:44,390 --> 00:35:50,050
+اللي بتضطر تجيب معاه إنزيمات. هذا مشكلة. أما اللي
+
+455
+00:35:50,050 --> 00:35:55,110
+بيجي بدون إنزيمات هذا عنده ميزة أو أفضلية و هنكلم
+
+456
+00:35:55,110 --> 00:36:00,190
+عنها جونة لاحقا. نرجع للـ RNA viruses كلهم single
+
+457
+00:36:00,190 --> 00:36:04,610
+-stranded ما عدا الريو فيروس و أخذنا مثال جونة
+
+458
+00:36:04,610 --> 00:36:09,890
+الروتا فيروس. they all replicate in the cytoplasm
+
+459
+00:36:09,890 --> 00:36:15,200
+ما عدا اتنين مشهورين برضه اللي هم الـ retro viruses
+
+460
+00:36:15,200 --> 00:36:20,240
+و الـ influenza virus. الـ retro اللي هي بتمثل مثال
+
+461
+00:36:20,240 --> 00:36:24,440
+عليها الـ aids الـ HIV virus و الـ influenza هي
+
+462
+00:36:24,440 --> 00:36:28,340
+الشهيرة و أشهر من أن إحنا نعرفها بحاجة تانية. both
+
+463
+00:36:28,340 --> 00:36:31,380
+of which have an important replicative steps in
+
+464
+00:36:31,380 --> 00:36:37,820
+the nucleus. لا أقول إن كل الـ replication في وين؟ في
+
+465
+00:36:37,820 --> 00:36:42,680
+الـ Nucleus بالنسبة للـ Retro-Influenza ولكن لديها
+
+466
+00:36:42,680 --> 00:36:46,320
+خطوات مهمة في الـ replication في الـ Nucleus. يعني
+
+467
+00:36:46,320 --> 00:36:50,180
+فيه جزء هيكون في الـ Cytoplasm و جزء وين؟ في الـ نواة
+
+468
+00:36:50,180 --> 00:36:55,860
+الـ Retrovirus integrate a DNA copy of their genome
+
+469
+00:36:55,860 --> 00:36:59,750
+into the host cell DNA. و هذا معروف عن الـ AIDS أن
+
+470
+00:36:59,750 --> 00:37:04,990
+الـ AIDS بيدخل جزء من الجينوم تبعه جوا الجينوم تبع
+
+471
+00:37:04,990 --> 00:37:09,630
+الـ host cell. هذا طبعا الجينوم هو الموجود في النواة
+
+472
+00:37:09,630 --> 00:37:12,490
+و لفسته بلازم في النواة و بالتالي هو لازم يروح على
+
+473
+00:37:12,490 --> 00:37:17,700
+النواة عشان يعمل integration للجينوم تبعه. بينما الـ
+
+474
+00:37:17,700 --> 00:37:22,240
+influenza viruses synthesize their progeny. طبعا
+
+475
+00:37:22,240 --> 00:37:25,960
+فاهمين شو يعني progeny؟ progeny يعني السلالة، السلالة أو
+
+476
+00:37:25,960 --> 00:37:30,420
+ما ينتج من الأبناء من الفيروس، their progeny
+
+477
+00:37:30,420 --> 00:37:33,240
+genomes in the nucleus. يبقى الـ influenza بتطلع
+
+478
+00:37:33,240 --> 00:37:38,650
+المادة الوراثية تبعتها من النواة. In addition the
+
+479
+00:37:38,650 --> 00:37:43,270
+mRNA of hepatitis delta virus. فاكرين الـ delta
+
+480
+00:37:43,270 --> 00:37:45,610
+virus اللي أخطأنا في المحاضرة السابقة لما قلنا الـ
+
+481
+00:37:45,610 --> 00:37:48,790
+defective virus؟ الـ defective virus بدو إيش مقال
+
+482
+00:37:48,790 --> 00:37:54,340
+له هذا؟ بدو helper virus. is also synthesized in the
+
+483
+00:37:54,340 --> 00:37:59,060
+nucleus of hepatocytes. إذن تلت أمثلة Retrovirus و
+
+484
+00:37:59,060 --> 00:38:02,420
+Influenza بالإضافة إلى مين؟ إلى الـ Hepatitis Delta
+
+485
+00:38:02,420 --> 00:38:07,060
+Virus من الـ RNA Viruses اللي بيتكاثروا داخل اللي
+
+486
+00:38:07,060 --> 00:38:12,320
+هو النواة. و الباقي في الـ Cytoplasm عكس الـ DNA Virus
+
+487
+00:38:12,320 --> 00:38:21,410
+ما الذي نفهمه من هذه اللوحة؟ أن مكان التكاثر تماما
+
+488
+00:38:21,410 --> 00:38:26,850
+إما النواة أو الـ cytoplasm أو أن هناك البعض
+
+489
+00:38:26,850 --> 00:38:36,050
+بيستغل النواة و الـ cytoplasm. لا يوجد قاعدة محددة
+
+490
+00:38:37,190 --> 00:38:41,230
+في الـ... الفيروسات. وجدنا أنه من... من الـ DNA
+
+491
+00:38:41,230 --> 00:38:45,830
+viruses واحد اللي بيحب وين يتكاثر في الـ cytoplasm
+
+492
+00:38:45,830 --> 00:38:50,410
+و الباقيين كلهم في اللي هو ال... الـ nucleus. بينما
+
+493
+00:38:50,410 --> 00:38:54,170
+في الـ RNA viruses كلهم في ال... في الـ cytoplasm
+
+494
+00:38:54,170 --> 00:38:57,150
+ماعدى استثناءات بسيطة في اللي هو الـ nucleus
+
+495
+00:38:59,970 --> 00:39:02,370
+هذه اللوحة بتوضح لنا ما يسمى بالـ replication
+
+496
+00:39:02,370 --> 00:39:07,290
+strategies. و أنا عندي صور أوضح منها إن شاء
+
+497
+00:39:07,290 --> 00:39:11,730
+الله هوريكم معاها. ناخذ فكرة عامة عن الـ double
+
+498
+00:39:11,730 --> 00:39:18,750
+stranded DNA viruses. دخل الفيروس و انراح على النواة
+
+499
+00:39:18,750 --> 00:39:21,950
+تمام؟ اللي هم بتطلع إيه؟ المعرضة اللي المعرضة
+
+500
+00:39:21,950 --> 00:39:24,050
+اللي هم بتروح؟ الـ cytoplasm لما إحنا نسير له
+
+501
+00:39:24,050 --> 00:39:24,790
+translation
+
+502
+00:39:29,230 --> 00:39:32,070
+الـ Early Protein بترجع على النوية و بيصير فيها 
+
+503
+00:39:32,070 --> 00:39:35,670
+عملية DNA Replication و ممكن يصير أنها لاية جينة
+
+504
+00:39:35,670 --> 00:39:38,810
+اللي هو Transcription و Translation اللي ساميها
+
+505
+00:39:38,810 --> 00:39:46,950
+أنا سكندري بعدين بتكون Structural Proteins اللي
+
+506
+00:39:46,950 --> 00:39:51,710
+هي الـ .. الـ capsids و بعدين بيصير فيها عملية جينة
+
+507
+00:39:51,710 --> 00:39:56,770
+انتقال أو Packagingاللي هي في المنطقة هاي صار فيه
+
+508
+00:39:56,770 --> 00:40:02,710
+packaging للفيروس فيه الكبسيد ومن ثم الـ release
+
+509
+00:40:02,710 --> 00:40:05,690
+اللي هي double stranded عن أن الفيروس عادة مرة
+
+510
+00:40:05,690 --> 00:40:08,650
+أخرى بس بدون كلام نتطلع عليها
+
+511
+00:40:47,970 --> 00:40:57,710
+الآن single-stranded DNA viruses طلعوا عليها برضه
+
+512
+00:40:57,710 --> 00:41:05,950
+روحنا على وين الـ single
+
+513
+00:41:05,950 --> 00:41:11,220
+-stranded اتحول لمين لـ double-strandedالفيروسات
+
+514
+00:41:11,220 --> 00:41:15,120
+ليست غبية بأن تغامر بالنسخة الأصلية تبعها تعمل 
+
+515
+00:41:15,120 --> 00:41:19,920
+دائماً copies و بتشتري عليها الـ copies كقوالب للشغل
+
+516
+00:41:19,920 --> 00:41:25,960
+تبعها تجريباً نفس الـ double stranded اللهم أنه في
+
+517
+00:41:25,960 --> 00:41:29,940
+إضافة خطوة إضافية يومها خطوة إضافية أن الـ single
+
+518
+00:41:29,940 --> 00:41:34,460
+stranded تحول إلى double stranded و الـ double
+
+519
+00:41:34,460 --> 00:41:39,840
+stranded بينتسخ منه نسخة بتصير قالب لتصنيع من الـ اللي
+
+520
+00:41:39,840 --> 00:41:42,680
+هو الـ Genome الأصلي اللي هو Single Stranded كمان
+
+521
+00:41:42,680 --> 00:41:42,940
+مرة
+
+522
+00:42:11,770 --> 00:42:14,550
+هي بده double strand لمين لـ single strand كمان
+
+523
+00:42:14,550 --> 00:42:20,330
+مرة عشان نصنع جينوم جديد
+
+524
+00:42:20,330 --> 00:42:27,070
+طيب نحاول أنه نغطي لوحده إن شاء الله و بعدين ننهي
+
+525
+00:42:27,070 --> 00:42:31,830
+محاضرتنا اليوم strategies of mRNA synthesizing in
+
+526
+00:42:31,830 --> 00:42:36,310
+RNA viruses mRNA synthesizing in RNA virus The
+
+527
+00:42:36,310 --> 00:42:40,370
+simplest strategy is illustrated by poliovirus،
+
+528
+00:42:40,370 --> 00:42:42,610
+الـ poliovirus اللي يقول عنه مراد فيروس شلل
+
+529
+00:42:42,610 --> 00:42:46,770
+للأطفال، which has a single-stranded RNA of
+
+530
+00:42:46,770 --> 00:42:51,410
+positive polarity، single-stranded positive
+
+531
+00:42:51,410 --> 00:42:54,850
+polarity، إيش معنى positive polarity؟ عكسه هيكون
+
+532
+00:42:54,850 --> 00:42:58,110
+إيش طبعاً، negative polarity، وباختصارا بيقولها
+
+533
+00:42:58,110 --> 00:43:01,940
+positive strand و negative strandالـ Postive
+
+534
+00:43:01,940 --> 00:43:06,120
+Strand هو الـ Strand اللي جاهز أنه يشتغل كـ mRNA
+
+535
+00:43:06,120 --> 00:43:13,440
+مباشرة وصلت ولا مصلتش يعني لو أنا عندي two strands
+
+536
+00:43:13,440 --> 00:43:17,380
+من
+
+537
+00:43:17,380 --> 00:43:24,090
+mRNA هذا strand وهذا strand كويس؟اللي فيهم already
+
+538
+00:43:24,090 --> 00:43:30,070
+بيركب عليه الـ ribosome وبيترجمه هذا اسمه positive
+
+539
+00:43:30,070 --> 00:43:34,990
+strand اللي بحاجة أن يصير له complementary strand
+
+540
+00:43:34,990 --> 00:43:38,450
+عشان يصير له translation هذا بيسميه negative strand
+
+541
+00:43:38,450 --> 00:43:41,270
+إذا فينا positive polarity و negative polarity
+
+542
+00:43:41,270 --> 00:43:46,010
+ومفهومهم كمان مرة الـ positive polarity can act as
+
+543
+00:43:46,010 --> 00:43:49,870
+an mRNA مباشرة بينما الـ negative polarity محتاج
+
+544
+00:43:49,870 --> 00:43:51,490
+إلى خطوة إضافية
+
+545
+00:43:56,410 --> 00:44:02,110
+طلعوا، these viruses uses أو use their RNA genome
+
+546
+00:44:02,110 --> 00:44:07,710
+directly as mRNA، هذه أبسط استراتيجية وموجودة في
+
+547
+00:44:07,710 --> 00:44:11,570
+مين؟ في الـ Polio virus. The second group has a
+
+548
+00:44:11,570 --> 00:44:15,290
+single-stranded RNA of negative polarity as its
+
+549
+00:44:15,290 --> 00:44:20,600
+genetic material.هدولة بالتأكيد الاستراتيجية
+
+550
+00:44:20,600 --> 00:44:24,320
+تبعتهم هتكون عبارة عن ايه يا شبنات؟ عبارة عن تكوين
+
+551
+00:44:24,320 --> 00:44:31,260
+complementary strand اللي هو هيكون a messenger RNA
+
+552
+00:44:31,260 --> 00:44:35,920
+بس مش مباشرة و هاد الفرق بين اللي هو الـ positive و
+
+553
+00:44:35,920 --> 00:44:39,940
+الـ single strand there are two sub categories of
+
+554
+00:44:39,940 --> 00:44:46,520
+negative polarity RNA virusesطبعا هذه العملية خدوا
+
+555
+00:44:46,520 --> 00:44:51,520
+بالكوا اللي هي تحويل الـ negative strand نعمله
+
+556
+00:44:51,520 --> 00:44:56,440
+positive strand مش موجودة في خلايانا فالفيروسات
+
+557
+00:44:56,440 --> 00:45:01,960
+اللي عندها negative strand لازم تجيب إنزيماتها
+
+558
+00:45:01,960 --> 00:45:06,580
+الخاصة فيها اللي بتحول الـ negative إلى positive
+
+559
+00:45:06,580 --> 00:45:10,880
+هذه كمان نقطة كتير مهمةاللي ماعندوش access
+
+560
+00:45:10,880 --> 00:45:15,300
+لإنزيماتنا، بده يجيب إنزيماته معاه، اللي ماعنداش
+
+561
+00:45:15,300 --> 00:45:19,400
+إنزيمات أصلاً للخطوة تبعته، بده يجيب إنزيماته معاه
+
+562
+00:45:19,400 --> 00:45:22,440
+في هذه الخلية، والمرة الجاية إن شاء الله يبنك 
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..93d1531c049f52886ab4fd19660e33ca1cce11a3
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg_postprocess.srt
@@ -0,0 +1,2248 @@
+1
+00:00:20,820 --> 00:00:22,780
+بسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:22,780 --> 00:00:25,820
+والصلاة والسلام وعلى سيدنا محمد وعلى آله وصحبه ومن
+
+3
+00:00:25,820 --> 00:00:29,520
+ساعد ربي اليوم الدين محاضرتنا اليوم ان شاء الله
+
+4
+00:00:29,520 --> 00:00:35,960
+بعنوان الـViral Replication وتعتبر من أهم المواضيع
+
+5
+00:00:35,960 --> 00:00:42,000
+في الـVirology نظرا لاختلاف الطريقة التي تتكثر بها
+
+6
+00:00:42,000 --> 00:00:46,000
+الفيروسات عن باق المخلوقات وللاختلاف الداخلي بين
+
+7
+00:00:46,000 --> 00:00:51,840
+هذه الفيروسات يعنينجد أن هناك DNA single-stranded
+
+8
+00:00:51,840 --> 00:00:55,660
+virus أكيد بالتأكيد هيختلف عن ال double-stranded و
+
+9
+00:00:55,660 --> 00:00:58,580
+كذلك الأمر بالنسبة لل single-stranded أو double
+
+10
+00:00:58,580 --> 00:01:02,780
+-stranded RNA فيروس هيكون فيها نوع من الإختلاف
+
+11
+00:01:02,780 --> 00:01:06,720
+المحتوى
+
+12
+00:01:06,720 --> 00:01:09,500
+هذه المحاضرة سيكون ان شاء الله مقدمة بسيطة عن
+
+13
+00:01:09,500 --> 00:01:15,090
+لماذا الفيروسات مختلفةسيكون هناك كيف ننظر نحن في
+
+14
+00:01:15,090 --> 00:01:18,310
+الـVirology للـreplication of viruses، هل ننظر له
+
+15
+00:01:18,310 --> 00:01:22,010
+بنفس الطريقة اللي بننظر للبكتيريا فيها و لا بطريقة
+
+16
+00:01:22,010 --> 00:01:26,150
+مختلفة، لأنهم أصلا هم مختلفين، هناك مصطلح اسمه
+
+17
+00:01:26,150 --> 00:01:32,850
+cytopathic effectعندما نقوم بوضع فيروس على خلايا
+
+18
+00:01:32,850 --> 00:01:37,710
+لتنميتها لتنمية هذه الفيروسات نجد أن بعض الفيروسات
+
+19
+00:01:37,710 --> 00:01:42,890
+تقوم بإحداث أثر سلبي في هذه الخلايا هذا الأثر
+
+20
+00:01:42,890 --> 00:01:48,750
+السلبي يسمى psychopathic effect أو اختصارا CPE ما
+
+21
+00:01:48,750 --> 00:01:53,590
+يميز هذا ال CPE هو أن الفيروس الذي يحدثه دائما
+
+22
+00:01:53,590 --> 00:01:58,740
+يحدثه ايش يعني؟يمكن الاستفادة من شكل الـCPE للتعرف
+
+23
+00:01:58,740 --> 00:02:02,640
+على الفيروس، إذن هي أحد طرق التعرف على الفيروس
+
+24
+00:02:02,640 --> 00:02:08,720
+سنطرق أيضًا في الـreplication إلى الخطوات المحددة
+
+25
+00:02:08,720 --> 00:02:13,140
+التي من خلالها يتكاثر الفيروس مثلًا سنتحدث عن
+
+26
+00:02:13,140 --> 00:02:16,620
+الـattachment، عن الـpenetration، عن الـuncoating
+
+27
+00:02:16,960 --> 00:02:22,320
+عن الـ early و ال .. ال .. ال genome replication و
+
+28
+00:02:22,320 --> 00:02:26,080
+ال late protein synthesis عن ال assembly للفيروس و
+
+29
+00:02:26,080 --> 00:02:33,120
+عن ال release لهذا الفيروس سنتحدث ايضا عن ال
+
+30
+00:02:33,120 --> 00:02:35,640
+infectious nucleic acid ايش يعني infectious
+
+31
+00:02:35,640 --> 00:02:40,680
+nucleic acid لكم انت تخيلوا ان الفيروس مكون رئيسيا
+
+32
+00:02:40,680 --> 00:02:47,220
+من ايش؟ من مادة وراثية و من capsidطب يا هل ترى لو
+
+33
+00:02:47,220 --> 00:02:51,480
+أخدنا الـNucleic Acid لوحده ووضعناه في خلايا، هل
+
+34
+00:02:51,480 --> 00:02:57,480
+سيكون قادر على التكاثر وإعادة دورة الحياة للفيروس
+
+35
+00:02:57,480 --> 00:03:01,620
+ولا لا؟ هذا بيعتمد، هناك بعض الفيروسات أو بعض
+
+36
+00:03:01,620 --> 00:03:04,840
+المادة اللي بنعطيها الفيروسات مؤدية والبعض الآخر
+
+37
+00:03:04,840 --> 00:03:09,300
+غير مؤدية، ما الذي يحدد؟ سنتعرف على هذا أيضا في
+
+38
+00:03:09,300 --> 00:03:14,700
+خلال محاضرة الـViral Replicationهتكلم عن الـ Viral
+
+39
+00:03:14,700 --> 00:03:19,760
+mRNA أول مرة بنتكلم عن جينوم أصلا مكون من RNA
+
+40
+00:03:19,760 --> 00:03:26,000
+فبالتالي كيف الـ Viral mRNA الناتجة من هذه الـ
+
+41
+00:03:26,000 --> 00:03:31,860
+Genomes كيف يتعامل معها في خلايانها كيف هي ال
+
+42
+00:03:31,860 --> 00:03:35,300
+استراتيجيات المختلفة لهذه الفيروسات في الـ
+
+43
+00:03:35,300 --> 00:03:38,540
+replication و أخر نقطة هتطرقلها في ال replication
+
+44
+00:03:38,540 --> 00:03:42,410
+في الـ Viral replication اللي هي ال ISO geneوالـ
+
+45
+00:03:42,410 --> 00:03:45,250
+Lysogeny مصطلح عرفته انتوا في الـ Essential
+
+46
+00:03:45,250 --> 00:03:47,970
+Medical Microbiology وعرفته في الـ Diagnostic
+
+47
+00:03:47,970 --> 00:03:51,670
+Microbiology لما تحدثنا عن قدرة بعض الفيروسات على
+
+48
+00:03:51,670 --> 00:03:56,690
+ال integration لدي الجينوم تبعها داخل الجينوم تبع
+
+49
+00:03:56,690 --> 00:04:02,070
+ال host cell وقولنا ان هناك أنواع من البكتيريالم
+
+50
+00:04:02,070 --> 00:04:06,890
+تكن لتكون أصلا سامة أو قادرة على إحداث المرض إلا
+
+51
+00:04:06,890 --> 00:04:10,850
+من خلال وجود فيروس داخلها وجود ال virus داخل
+
+52
+00:04:10,850 --> 00:04:14,450
+الخلية هذا اللي بيسميه احنا lysogeny كلمة وجوده
+
+53
+00:04:14,450 --> 00:04:21,820
+داخل الخلية بشكل مختفي داخل ال genomeنبدأ بالمقدمة
+
+54
+00:04:21,820 --> 00:04:25,980
+البسيطة اللي وعدناكم فيها وهي أن الفيروسات مختلفة
+
+55
+00:04:25,980 --> 00:04:30,760
+ما هو وجه الاختلاف في الفيروسات they are obligate
+
+56
+00:04:30,760 --> 00:04:33,780
+intracellular parasites they cannot replicate
+
+57
+00:04:33,780 --> 00:04:38,580
+independently يعني لازم داخل خلية وهذه نقطة لم
+
+58
+00:04:38,580 --> 00:04:42,180
+نجدها في المخلوقات الأخرى إلا في بكتيريا من نوعين
+
+59
+00:04:42,180 --> 00:04:47,390
+جُن عنهم كلاميديا and ركيزيViruses do not undergo
+
+60
+00:04:47,390 --> 00:04:54,330
+عملية الـ simple binary vision أو الـ mitosis و
+
+61
+00:04:54,330 --> 00:05:00,970
+الmyosis إذن الفيروسات مختلفة وبالتالي لازم نعرف
+
+62
+00:05:00,970 --> 00:05:06,970
+كيف الفيروسات بتتكاثر لماذا نريد معرفة التفاصيل
+
+63
+00:05:06,970 --> 00:05:11,520
+تبع تكاثر الفيروسات؟عارفين ليش؟ لأن معرفتنا
+
+64
+00:05:11,520 --> 00:05:15,900
+بالتفاصيل الدقيقة بتخلينا ناخد استراتيجيات كيف
+
+65
+00:05:15,900 --> 00:05:21,180
+نوقف هذا التكاثر ماذا يعني بإيقاف التكاثر؟ إيقاف
+
+66
+00:05:21,180 --> 00:05:26,860
+المرض أو علاج المرض، مظبوط؟ إذا ال specific events
+
+67
+00:05:26,860 --> 00:05:31,520
+اللي بنتكلم عنها ضرورية حتى نعلم ما هي استراتيجية
+
+68
+00:05:31,520 --> 00:05:35,640
+الفيروس في التكاثر وكيف سنكافح هذه الاستراتيجيات
+
+69
+00:05:36,690 --> 00:05:40,290
+أيضا نقطة اختلاف مهمة أنه إذا كنا نعرف أن البكتيرا
+
+70
+00:05:40,290 --> 00:05:48,430
+تنقسم من قول 1,2,4,8,16,32,64 لكن الفيروسات بيدخل
+
+71
+00:05:48,430 --> 00:05:53,490
+one virus داخل الخلية وبيطلع بعد عدة ساعات مئات من
+
+72
+00:05:53,490 --> 00:05:58,450
+ال viruses يبقى بالتأكيد كل ما يتعلق بال
+
+73
+00:05:58,450 --> 00:06:01,970
+replication تبقى ال virus مختلف تماما عن مين عن
+
+74
+00:06:01,970 --> 00:06:08,960
+المخلوقات الأخرىطيب احنا كدارسين لل .. للفيروسات
+
+75
+00:06:08,960 --> 00:06:13,700
+كيف لنا ان نعرف ال replication في الفيروس؟ هل
+
+76
+00:06:13,700 --> 00:06:18,000
+نعرفه بنفس الطريقة اللي عرفنا فيها ال replication
+
+77
+00:06:18,000 --> 00:06:23,020
+في البكتيريا؟ بمعنى كنا نتكلم عن lag, log,
+
+78
+00:06:24,100 --> 00:06:27,360
+stationary, death phase فاكرين ال growth curve تبع
+
+79
+00:06:27,360 --> 00:06:31,360
+البكتيريا؟ نعم يمكن لنا ان نتعامل مع الفيروس بهذه
+
+80
+00:06:31,360 --> 00:06:35,310
+الطريقةبندخل الفيروسات في الخلايا وبنعدل الفيروسات
+
+81
+00:06:35,310 --> 00:06:40,450
+كل ساعة ساعتين تلاتة وممكن نعمل curve لكن في مشكلة
+
+82
+00:06:40,450 --> 00:06:45,910
+هنا ان في لحظة من اللحظات الفيروس هيدخل داخل
+
+83
+00:06:45,910 --> 00:06:51,630
+الخلايا ومش هقدر اعده انا مش هقدر اشوفه هيختفي عن
+
+84
+00:06:51,630 --> 00:06:56,390
+ناظري ولا انا استطيع ان اقوم بقياسه اصلاوهذه مشكلة
+
+85
+00:06:56,390 --> 00:07:01,770
+كبيرة الخيار التاني أن أنظر إذا التكاثر تبع
+
+86
+00:07:01,770 --> 00:07:05,490
+الفيروسات بطريقة ال specific events اللي حكينا
+
+87
+00:07:05,490 --> 00:07:11,210
+عنها Attachment Penetration Uncoating Early mRNA
+
+88
+00:07:11,210 --> 00:07:16,330
+Early Protein Genome Replication Late mRNA Late
+
+89
+00:07:16,330 --> 00:07:20,710
+Protein بعدين Assembly بعدين Release هذه ال
+
+90
+00:07:20,710 --> 00:07:25,290
+specific event إذا الخطوة الأولىان تطلع عليها ك
+
+91
+00:07:25,290 --> 00:07:29,790
+growth curve و تطلع على الفقرة او الفترة مابين
+
+92
+00:07:29,790 --> 00:07:34,670
+واحد و مابين خمسة الفيروس غير موجود البتة مانا
+
+93
+00:07:34,670 --> 00:07:37,190
+احنا بدنا الفيروس واحد على المنطقة اللي شايفينها
+
+94
+00:07:37,190 --> 00:07:41,330
+هاي هانا بنتكلم على one single virus دخلناها في
+
+95
+00:07:41,330 --> 00:07:46,690
+الخلايا او في ال .. في ال growth يعني اختفى و فترة
+
+96
+00:07:46,690 --> 00:07:50,610
+الاختفاء بيسموها eclipse periodEclipse يعني الكثوف
+
+97
+00:07:50,610 --> 00:07:56,250
+تمام اختفى عن الأنظار وبعد عدة ساعات بدأ يظهر
+
+98
+00:07:56,250 --> 00:08:01,230
+المادة الوراثية تبعته وبيظهر الفيروس نفسه، إذا هذه
+
+99
+00:08:01,230 --> 00:08:05,230
+تشبه ال growth curve تبع مين؟ تا البكتيريا، لكن
+
+100
+00:08:05,230 --> 00:08:09,710
+كما ذكرت لكم أحد عيوبها إن في عندي فترة اختفاء لا
+
+101
+00:08:09,710 --> 00:08:14,420
+أستطيع قياس الفيروس فيهاالـ cytopathic effect
+
+102
+00:08:14,420 --> 00:08:19,160
+التعريف اللي ذكرناه وقلنالكم هو التأثير الحاصل على
+
+103
+00:08:19,160 --> 00:08:24,000
+الخلايا التي ينمو عليها الفيروس وكونكم لسه ما
+
+104
+00:08:24,000 --> 00:08:28,460
+اتعلمتوش كيف الفيروس أصلا بينمو وبيتكاثر في المعمل
+
+105
+00:08:28,460 --> 00:08:34,340
+بدنا نوضحلكم مثلًا لو افترضنا هذا الجوال عبارة عن
+
+106
+00:08:34,340 --> 00:08:42,380
+بطل شفافة ويلها عنق وغطاءوادخلنا من هذا الغطاء
+
+107
+00:08:42,380 --> 00:08:47,920
+مادة مغذية وادخلنا خلايا آدمية الخلايا الآدمية
+
+108
+00:08:47,920 --> 00:08:52,120
+نفترض أنها من أي عضو من عضاء الدسم لما تتكاثر
+
+109
+00:08:52,120 --> 00:08:57,500
+الخلايا الآدمية جوا، تتكثرش وبتكون أنه عضو، تتكاثر
+
+110
+00:08:57,500 --> 00:09:04,000
+وبتكون طبقة سطحية mono layer طبقة واحدة من الخلايا
+
+111
+00:09:04,940 --> 00:09:09,480
+هذا النوع من الخلايا استطيع ان افحصه تحت ال
+
+112
+00:09:09,480 --> 00:09:12,840
+microscope و ارى ما يسمى بال normal morphology
+
+113
+00:09:12,840 --> 00:09:17,840
+الشكل الطبيعي لهذا الخلايا تمام؟ و كل نوع خلايا له
+
+114
+00:09:17,840 --> 00:09:23,000
+normal morphology لو وضعنا virus عليه و ال virus
+
+115
+00:09:23,000 --> 00:09:27,820
+قلنا لكم من النوع اللي بدمر الخلايا تمام؟ بدمرها
+
+116
+00:09:27,820 --> 00:09:33,510
+كل مرة بنفس الطريقةالتدمير هذا بنسميه cytopathic
+
+117
+00:09:33,510 --> 00:09:37,690
+effect كيف ممكن أفحصه؟ مرة أخرى تحت ال microscope
+
+118
+00:09:37,690 --> 00:09:40,810
+في عندي normal morphology وفي عندي abnormal
+
+119
+00:09:40,810 --> 00:09:44,650
+morphology ال abnormal morphology هي ال cytopathic
+
+120
+00:09:44,650 --> 00:09:47,990
+effect اللي احنا بنشوفه ايش ممكن نشوف؟ ممكن نشوف
+
+121
+00:09:47,990 --> 00:09:52,430
+فجواتفي النمو بدل ما هي مونولية مغطية تماما نشوف
+
+122
+00:09:52,430 --> 00:09:57,990
+فجوات ممكن نشوف خلايا بيسميها Multi-Nucleated
+
+123
+00:09:57,990 --> 00:10:03,350
+Giant Cell ايش يعني Multi-Nucleated Giant Cell
+
+124
+00:10:03,350 --> 00:10:07,910
+خلية عملاقة Multi-Nucleated يعني فيها العديد من
+
+125
+00:10:07,910 --> 00:10:12,130
+الأنوية عبارة عن ايش هي دي عبارة عن خلايا عادية
+
+126
+00:10:12,130 --> 00:10:17,370
+الفيروس لما عملها infectionأزال الفواصل اللي بينها
+
+127
+00:10:17,370 --> 00:10:21,510
+فأصبحت وكاينها خلية كبيرة لكن الأنمي تبعتها ما
+
+128
+00:10:21,510 --> 00:10:26,370
+زالت موجودة هذا الفيروس كل مرة بيعمل نفس ال
+
+129
+00:10:26,370 --> 00:10:29,390
+infection بيعمل نفس ال cytopathic effect إذا
+
+130
+00:10:29,390 --> 00:10:34,370
+اتفقنا على ان ال cytopathic effect هو تأثير لبعض
+
+131
+00:10:34,370 --> 00:10:37,770
+الفيروسات مش كل الفيروسات لبعض الفيروسات على
+
+132
+00:10:37,770 --> 00:10:41,850
+الخلايا اللي بينمو عليها هذا الفيروس ومن خلالها
+
+133
+00:10:41,850 --> 00:10:45,370
+نستطيع التعرف على مينعلى الفيروسات أعطيكم مثال
+
+134
+00:10:45,370 --> 00:10:53,590
+صغير في فيروس اسمه Respiratory Syncytial Virus RSV
+
+135
+00:10:53,590 --> 00:10:58,410
+Respiratory Syncytial Virus كلمة Syncytia تجمية
+
+136
+00:10:58,410 --> 00:11:03,030
+فهو بيروح .. الخلايا بتكون خلايا normal morphology
+
+137
+00:11:03,030 --> 00:11:07,790
+بيروح بيجمعها مع بعض كل مرة بشوف هذا التجميع بقول
+
+138
+00:11:07,790 --> 00:11:13,090
+ان الفيروس اسمه RSVفي فيروس تاني اسمه
+
+139
+00:11:13,090 --> 00:11:16,510
+cytomegalovirus لما بيعمل infection للخلايا
+
+140
+00:11:16,510 --> 00:11:22,730
+الخلايا نفسها بيصير تحتوي على عينتين شكل عينتين
+
+141
+00:11:22,730 --> 00:11:27,730
+تحت الميكروسكوب بنسميهم owl's eye عارفين شنه owl؟
+
+142
+00:11:27,730 --> 00:11:33,370
+البومة زي عينين؟ البومة تمام؟ هذا شكل مميز ومميز
+
+143
+00:11:33,370 --> 00:11:37,390
+للـcytomegalovirus إيه تاني الـcytopathic effect
+
+144
+00:11:37,390 --> 00:11:40,730
+هو أحد الوسائل اللي من خلالها ممكن نتعرف على مين
+
+145
+00:11:40,730 --> 00:11:43,980
+يا بنات؟على الفيروسات طبعا مش على كل الفيروسات لأن
+
+146
+00:11:43,980 --> 00:11:49,620
+مش كل الفيروسات أصلا بتعمل psychopathic effect طيب
+
+147
+00:11:49,620 --> 00:11:53,400
+نيجي الآن لل specific events during the growth
+
+148
+00:11:53,400 --> 00:11:56,480
+cycle وانا ممكن كررتهم مرتين من أول المحاضرة
+
+149
+00:11:56,480 --> 00:12:00,660
+وسأكررهم للمرة الثالثة والرابع أو الخمسة عشان نطلع
+
+150
+00:12:00,660 --> 00:12:05,810
+من المحاضرة ان شاء الله حافظينهم غيباattachment
+
+151
+00:12:05,810 --> 00:12:10,350
+and penetration of parental virus ال parental يعني
+
+152
+00:12:10,350 --> 00:12:12,490
+الفيروس الأب اللي هو ال original الفيروس ال
+
+153
+00:12:12,490 --> 00:12:17,730
+original attachment و بعدين إيش penetration خدوا
+
+154
+00:12:17,730 --> 00:12:23,610
+بالكوا أنا بتكلم عن specific events لكل الفيروسات
+
+155
+00:12:23,610 --> 00:12:28,270
+لكن لما يدخلوا في التفاصيل هلاجي إنه ال attachment
+
+156
+00:12:28,270 --> 00:12:33,120
+من فيروس لفيروس بتختلفالـ penetration من فيروس
+
+157
+00:12:33,120 --> 00:12:36,700
+لفيروس تختلف يبقى .. احنا بتكلم على ايه؟ على
+
+158
+00:12:36,700 --> 00:12:39,980
+specific event for the whole process for all
+
+159
+00:12:39,980 --> 00:12:44,140
+viruses Uncoating of the viral genome، إيش يعني
+
+160
+00:12:44,140 --> 00:12:48,700
+uncoating؟ فصل المادة الوراثية عن الكبسيد وإذا كان
+
+161
+00:12:48,700 --> 00:12:54,180
+فيه أصلاً coat عفوا، envelope عشان نحرر المادة
+
+162
+00:12:54,180 --> 00:13:01,380
+الوراثية Early viral mRNA synthesisليش بنعمل الـ
+
+163
+00:13:01,380 --> 00:13:04,440
+mRNA synthesis؟ عشان نطلع البروتين، عشان نطلع
+
+164
+00:13:04,440 --> 00:13:10,960
+البروتين شوفوا عليا، لو أنا بدي أحاول أبني بيت،
+
+165
+00:13:10,960 --> 00:13:17,160
+قبل ما أبني البيت، بدي أجيب من؟ الأدوات، الأدوات
+
+166
+00:13:17,160 --> 00:13:21,580
+اللي بدي أصنع فيها هذا البيت، فالـ Early الـ Early
+
+167
+00:13:22,560 --> 00:13:27,220
+mRNA و early protein في الغالب يا بنات هي لتصنيع
+
+168
+00:13:27,220 --> 00:13:33,140
+الانزيمات اللازمة لتصنيع الفيروس في الآخر يبقى هي
+
+169
+00:13:33,140 --> 00:13:38,120
+مرحلة تحضيرية للفيروس في النصف في عندنا حاجة اسمها
+
+170
+00:13:38,120 --> 00:13:41,060
+viral genome replication والمسؤول عن ال genome
+
+171
+00:13:41,060 --> 00:13:46,100
+viral replication هم الـ early protein أصلا بعد ما
+
+172
+00:13:46,100 --> 00:13:52,430
+صنعنا المادة الوراثية الأساسية للفيروس تمامنبدأ
+
+173
+00:13:52,430 --> 00:13:57,190
+الأن نصنع الـ Late mRNA والـ Late Protein ايش هما
+
+174
+00:13:57,190 --> 00:14:00,090
+ال Late mRNA وال Late Protein؟ هما البروتينات
+
+175
+00:14:00,090 --> 00:14:06,090
+اللازمة لبناء الفيروس زي مثلا الـ Capsomers تمام؟
+
+176
+00:14:06,090 --> 00:14:09,390
+إذا كان بدنا تجيومنت، إذا كان بدنا enzymes معينة
+
+177
+00:14:09,390 --> 00:14:13,890
+ناخدها معانا على الخلايا الأخرى، هذه كلها بتتم في
+
+178
+00:14:13,890 --> 00:14:18,430
+مرحلة مين؟ ال Late mRNA وال Late Protein Synthesis
+
+179
+00:14:19,070 --> 00:14:23,690
+بعدين صار عندى الان مادة وراثية صار عندى وحدات
+
+180
+00:14:23,690 --> 00:14:29,770
+بنائية العملية التالية هي التجميع حط ال DNA جوا ال
+
+181
+00:14:29,770 --> 00:14:33,770
+capsid حط ال DNA جوا ال capsid المحاضرة اللى فاتت
+
+182
+00:14:33,770 --> 00:14:37,530
+لما كلمنا عن ال pseudo virion لما قلنالكوا بعض
+
+183
+00:14:37,530 --> 00:14:42,750
+الأحيان الفيروسات بتخطأ و بتحط مادة وراثية هذا متى
+
+184
+00:14:42,750 --> 00:14:46,230
+بتتم في عملية ال assembly اللى المرحلة اللى قبل
+
+185
+00:14:46,230 --> 00:14:50,670
+الأخرىطب بعد ما عملنا assembly ايش دلوقت للفيروس؟
+
+186
+00:14:50,670 --> 00:14:58,010
+لازم ايش يعمل الآن؟ ينطلق، release، بتحرر، بعض
+
+187
+00:14:58,010 --> 00:15:02,710
+الفيروسات بتتحرر بإنها بتحلل الخلية وبعض
+
+188
+00:15:02,710 --> 00:15:05,590
+الفيروسات، وهذا على فكرة بتعمل psychopathic effect
+
+189
+00:15:05,590 --> 00:15:09,390
+لإنها بتدمر الخلية، وبعض الفيروسات بتطلع بأدب،
+
+190
+00:15:09,390 --> 00:15:12,720
+واحد واحدبيطلع بياخد معاها قطعة من ال cell
+
+191
+00:15:12,720 --> 00:15:15,960
+membrane و بيلزج ال cell membrane وراها فبتضل
+
+192
+00:15:15,960 --> 00:15:21,600
+الخلية و كأنها ما فيها اي ضرر و بيطلع الفيروسات
+
+193
+00:15:21,600 --> 00:15:26,140
+تباعا منها و مابصيرش فيها cytopathic effect يعرفنا
+
+194
+00:15:26,140 --> 00:15:30,440
+من وين بيلي cytopathic effect من تكاثر الفيروس او
+
+195
+00:15:30,440 --> 00:15:33,960
+من اطلاق الفيروس اللي هو ال release تبع هذا
+
+196
+00:15:33,960 --> 00:15:42,220
+الفيروسالشكل اللي أمامنا لابد من تطبيق ما ذكرناه
+
+197
+00:15:42,220 --> 00:15:47,140
+من events على هذا الشكل واللوحة اللي أمامكم هي
+
+198
+00:15:47,140 --> 00:15:53,280
+عبارة عن التكاثر في ال adenovirus واحد من أكتر
+
+199
+00:15:53,280 --> 00:15:57,580
+الفيروسات اللي دُرست فيها ال replication cycle
+
+200
+00:15:58,110 --> 00:16:01,290
+والعملية السهلة هي ال adenovirus اللي هو اللي
+
+201
+00:16:01,290 --> 00:16:05,390
+ممثله بانه e-causa هيدرال الخلية اللي أمامنا هذه
+
+202
+00:16:05,390 --> 00:16:11,110
+امثلة على انها host cell هذا cytoplasm وهذه
+
+203
+00:16:11,110 --> 00:16:16,350
+الكبيرة النواء ليش هو كبر النواء مع أنها مش هالجد
+
+204
+00:16:16,350 --> 00:16:21,470
+حجمها عشان الرسمة عشان هذا الفيروس جزء من جزء كبير
+
+205
+00:16:21,470 --> 00:16:26,130
+من الأنشطة طبعته بتتم في وين في النواء وهذه نقطة
+
+206
+00:16:26,130 --> 00:16:30,570
+بدنا ننتبه لها من الآنإن كثير من الفيروسات تتكاثر
+
+207
+00:16:30,570 --> 00:16:35,970
+تماما في الـ cytoplasm بتروح لمين؟ على النواء، وفي
+
+208
+00:16:35,970 --> 00:16:41,050
+فيروسات لابد من أن تذهب إلى النواء، إذا بيختلفوا
+
+209
+00:16:41,050 --> 00:16:44,940
+عن بعض في هذا الجزءAttachment, Penetration,
+
+210
+00:16:46,100 --> 00:16:50,140
+Uncoating وين المادة دلوقتي راحت على الدوام Early
+
+211
+00:16:50,140 --> 00:16:53,680
+transcription, Early translation, Synthesis للـ
+
+212
+00:16:53,680 --> 00:16:57,260
+Early protein اللي هي ال enzymes زي ال DNA
+
+213
+00:16:57,260 --> 00:17:00,640
+polymerases وكانت هاي أدوات اللي بنستخدمها في
+
+214
+00:17:00,640 --> 00:17:04,120
+التصنيعبعدين في عندي هنا اللي هو ال synthesis
+
+215
+00:17:04,120 --> 00:17:09,880
+للمادة الوراثية تمام اللي هي للفيروس نفسه بعدين ال
+
+216
+00:17:09,880 --> 00:17:14,300
+mRNA و ال protein ال late بعد هيك assembly لاحظوا
+
+217
+00:17:14,300 --> 00:17:20,060
+الآن إيش صار عندي فيروس كامل داخله مادة وراثية و
+
+218
+00:17:20,060 --> 00:17:24,960
+بعدين release إذا الخطوات اللي ذكرناهم أن أدهم مع
+
+219
+00:17:24,960 --> 00:17:27,300
+بعض أنا بدي أدهم و شوفوا حالكوا حافظوا إن هم ولا
+
+220
+00:17:27,300 --> 00:17:30,700
+لأ attachment penetration
+
+221
+00:17:32,670 --> 00:17:37,470
+uncoating، early mRNA synthesis، late mRNA
+
+222
+00:17:37,470 --> 00:17:43,110
+synthesis، في النص اللي هو ال genome replication،
+
+223
+00:17:43,110 --> 00:17:47,590
+بعدين late protein، عفوا، late mRNA synthesis،
+
+224
+00:17:47,590 --> 00:17:52,010
+late protein synthesis assembly and release، هاي
+
+225
+00:17:52,010 --> 00:17:56,850
+عشر خطوات كاملين بيوضحوننا ل specific events لany
+
+226
+00:17:56,850 --> 00:18:02,550
+virus أو any viral replicationنبدأ بالخطوة الأولى
+
+227
+00:18:02,550 --> 00:18:06,430
+احنا قلنا ان هذه معلومات عامة الآن نتكلم عن بعض
+
+228
+00:18:06,430 --> 00:18:11,330
+التفاصيل attachment والـ attachment لا تتم يا بنات
+
+229
+00:18:11,330 --> 00:18:16,150
+إلا من خلال receptors وهذا على فكرة بيثير سؤال
+
+230
+00:18:16,150 --> 00:18:19,610
+كتير بيسألون الطلبة طب هو احنا يا دكتور مصممين
+
+231
+00:18:19,610 --> 00:18:23,750
+اصلا ال receptors تبعتنا يعني خليانا مصمم عشان
+
+232
+00:18:23,750 --> 00:18:30,120
+تنصب الفيروس ايش رأيكم؟مدام .. مدام الارتباط هو
+
+233
+00:18:30,120 --> 00:18:35,860
+اصلا من خلال receptors ال
+
+234
+00:18:35,860 --> 00:18:39,020
+.. ال .. ال receptor احنا .. احنا المستقبلين ال
+
+235
+00:18:39,020 --> 00:18:42,820
+antigen اللي بده ارتبط معانا تمام احنا receptor هو
+
+236
+00:18:42,820 --> 00:18:47,560
+antigen فهل هو احنا مصممين ان يكون عندنا receptors
+
+237
+00:18:47,560 --> 00:18:49,540
+لهذه ال antigen ات انا السؤال
+
+238
+00:18:54,000 --> 00:18:59,920
+الريسبتور ليس ضعف وليس ضعف، هو مركّب موجود على
+
+239
+00:18:59,920 --> 00:19:02,960
+الخلايا تبعتنا، الجواب
+
+240
+00:19:04,420 --> 00:19:09,000
+الفيروسات بتستغل receptors normally have functions
+
+241
+00:19:09,000 --> 00:19:12,660
+in our body يعني في الهواء ضائف في أجسامنا
+
+242
+00:19:12,660 --> 00:19:16,280
+بتستغلها هذه الفيروسات مثلا ناخد أصل اللوحة اللي
+
+243
+00:19:16,280 --> 00:19:19,820
+بعديها على السرية و بيبين أنه جال اللوحة هذه كلكوا
+
+244
+00:19:19,820 --> 00:19:23,960
+بتعرفوا أن ال CD4 هو موجود على ال T-Helper cells
+
+245
+00:19:25,010 --> 00:19:29,770
+والـ T-Helper Cells تستخدمه للارتباط بـ Class II
+
+246
+00:19:29,770 --> 00:19:33,110
+MHC اللي هو الـ Major Histocompatibility Complex
+
+247
+00:19:33,110 --> 00:19:38,350
+عشان تعمل activation للـ Helper T Cell يعني في الـ
+
+248
+00:19:38,350 --> 00:19:42,170
+CD4 هذا اللي ماله له Normal Function مين اللي
+
+249
+00:19:42,170 --> 00:19:50,270
+بيرتبط فيه؟ الـ HIVالـ HIV استغل الـ CD4 ريسبتور
+
+250
+00:19:50,270 --> 00:19:54,350
+تمام في الإرتباط لكن CD4 لها normal function عندنا
+
+251
+00:19:54,350 --> 00:19:59,650
+ناخد مثال تاني ال rabies اللي هو ده السعر أو
+
+252
+00:19:59,650 --> 00:20:05,090
+الفيروس ده السعر أو الكلببيرتبط بالـ Acetylcholine
+
+253
+00:20:05,090 --> 00:20:08,550
+ريسبتور، مين ماعندوش فينا Acetylcholine ريسبتور؟
+
+254
+00:20:08,550 --> 00:20:12,410
+كلنا عندنا .. أقولكوا كل الثدييات لديها
+
+255
+00:20:12,410 --> 00:20:17,150
+Acetylcholine وبالتالي هذا الفيروس يصيب كل
+
+256
+00:20:17,150 --> 00:20:21,570
+الثديياتطب الأستيالكولين هو أصلا نيرو ترانزميتر
+
+257
+00:20:21,570 --> 00:20:24,630
+وبالتالي لازم يكون فيه أنها ريسبتور، ال rabies
+
+258
+00:20:24,630 --> 00:20:27,910
+استغل هذا الريسبتور في الإرتباط، فإن ال Epstein
+
+259
+00:20:27,910 --> 00:20:31,230
+-Barr أو ال بيشتعين بار فيروس بيرتبط بالكمبلمنت
+
+260
+00:20:31,230 --> 00:20:33,590
+ريسبتور والكمبلمنت يوزق من our immune system
+
+261
+00:20:33,590 --> 00:20:37,330
+وبالتالي بالفعل لازم يكون موجودالـ Vaccinia Virus
+
+262
+00:20:37,330 --> 00:20:40,310
+بيرتبط بالـ Epidermal Growth Factor وهذا أيضًا
+
+263
+00:20:40,310 --> 00:20:45,510
+فاكتور مهم إلنا والأصل إنه يكون موجود لكن الـ
+
+264
+00:20:45,510 --> 00:20:48,170
+Virus أو الـ Vaccinia Virus بيرتبط فيه الـ
+
+265
+00:20:48,170 --> 00:20:52,690
+Rhinovirus، الفيروس الرشح بيرتبط في الـ Receptor
+
+266
+00:20:52,690 --> 00:20:56,710
+بيسموه ICAM-1 أو Intracellular Adhesion Molecule-1
+
+267
+00:20:56,710 --> 00:20:59,590
+وهذا أيضًا من الـ Receptors اللي المفروض تكون
+
+268
+00:20:59,590 --> 00:21:02,390
+موجودة في الإنسان ويقولها Normal Function إذن
+
+269
+00:21:02,390 --> 00:21:08,220
+الفيروسات ترتبطبالرسيبتورز normally لها normal
+
+270
+00:21:08,220 --> 00:21:10,900
+function عند الإنسان نرجع برجوع على اللوحة اللي
+
+271
+00:21:10,900 --> 00:21:19,220
+قبلها نقول انه طالما ان ال attachment specific
+
+272
+00:21:19,220 --> 00:21:23,680
+يبجى هي المسؤولة عن ال species ال specificity و ال
+
+273
+00:21:23,680 --> 00:21:27,700
+host range ايش يعني host range فاكرين في البكتيريا
+
+274
+00:21:27,700 --> 00:21:31,440
+كنا نتكلم عن أختين سلمونيلا وشجلة كنا نقول
+
+275
+00:21:31,440 --> 00:21:37,100
+السلمونيلا بتصيبالسحالي بتصيب الحرادين بتصيب
+
+276
+00:21:37,100 --> 00:21:41,580
+التنمساح بتصيب الدواجن بتصيب البنات من؟ إلها host
+
+277
+00:21:41,580 --> 00:21:47,240
+range واسة بينما الشيء اللي لا تصيب إلا الإنسان
+
+278
+00:21:47,240 --> 00:21:53,670
+host range ضيقالفيروسات كذلك الأمر في منها ما هو
+
+279
+00:21:53,670 --> 00:21:58,450
+wide أو ال host range واسع وفي منها ال host range
+
+280
+00:21:58,450 --> 00:22:03,050
+ضيق مثل ال poliovirus ال polyو اللي هو مرض شلل
+
+281
+00:22:03,050 --> 00:22:08,890
+الأطفال أو فيروس شلل الأطفال يصيب فقط الإنسان و ال
+
+282
+00:22:08,890 --> 00:22:11,570
+primates ال primates اللي هم زي القيرة ده ال
+
+283
+00:22:11,570 --> 00:22:16,690
+gorilla و الشمبانزيبينما ال rabies virus اللي احنا
+
+284
+00:22:16,690 --> 00:22:20,890
+ذكرناه قبل قليل فكينو ال rabies بيصيب بأي ريسبتور
+
+285
+00:22:20,890 --> 00:22:25,770
+الacetylcholine وقلنالكوا الacetylcholine موجود في
+
+286
+00:22:25,770 --> 00:22:28,970
+كل ال mammals و بتالي طالع هو اللي بيصيب هنا بيصيب
+
+287
+00:22:28,970 --> 00:22:33,550
+كل ال mammalian cells يدن ال rabies virus wide
+
+288
+00:22:33,550 --> 00:22:37,770
+range ال host wide range بينما ال ال ال ال
+
+289
+00:22:37,770 --> 00:22:41,210
+poliovirus narrow range مين المسئول عن الكلام هذا؟
+
+290
+00:22:42,910 --> 00:22:46,130
+وجود receptor والدليل على ذلك انه احنا بنتكلم على
+
+291
+00:22:46,130 --> 00:22:50,670
+ان الارتباط specific ومدام specific فهو اللذي
+
+292
+00:22:50,670 --> 00:22:55,950
+سيحدد ال host وهو اللذي سيحدد ال organ وهذا الكلام
+
+293
+00:22:55,950 --> 00:22:59,530
+حكيناه من اول محاضرة لما قلنالكوا species and
+
+294
+00:22:59,530 --> 00:23:05,050
+organ specificity are determined by the proteins
+
+295
+00:23:05,050 --> 00:23:09,050
+ال outer proteins اما على ال envelope او على ال
+
+296
+00:23:09,050 --> 00:23:11,050
+capsid في حال عدم موجود envelope
+
+297
+00:23:13,870 --> 00:23:19,150
+الـ penetration كلمة penetration يعني هو التثق وهو
+
+298
+00:23:19,150 --> 00:23:22,450
+خطوة أولى كويس انه التثق و specific receptor و non
+
+299
+00:23:22,450 --> 00:23:26,190
+-covalent bonding وغالبا ال bond بتكون weak bond
+
+300
+00:23:26,190 --> 00:23:31,150
+يعني رابطة ضعيف لحظة في ال penetration ممكن يكون
+
+301
+00:23:31,150 --> 00:23:36,210
+fusion with host cell membrane لما كان ال virus
+
+302
+00:23:36,210 --> 00:23:42,420
+envelope و هذا التثق بالخلية هاي ال virusهذه
+
+303
+00:23:42,420 --> 00:23:49,700
+الخلية وهذا الفيروس الان الفيروس يمتلك ممبرين من
+
+304
+00:23:49,700 --> 00:23:56,150
+جنس الممبرين تبع ال hostواذا بتذكروا لما شرحنالكوا
+
+305
+00:23:56,150 --> 00:24:00,610
+ال membrane قولنالكوا هو عبارة عن viscous مش حاجة
+
+306
+00:24:00,610 --> 00:24:04,810
+صلبة يعني سهل جدا انه يمتزج ال viscous مع ال
+
+307
+00:24:04,810 --> 00:24:07,570
+viscous وبالتالي ال membrane مع ال membrane
+
+308
+00:24:07,570 --> 00:24:13,900
+هيمتزجوا مع بعض والفيروس هيجعجوا الخليةهذا من خلال
+
+309
+00:24:13,900 --> 00:24:18,620
+مين؟ fusion with the whole cell membrane في طريقة
+
+310
+00:24:18,620 --> 00:24:22,480
+تانية زي اللي احنا شايفينها هنا اسمها endocytosis
+
+311
+00:24:22,480 --> 00:24:27,140
+او penocytosis مش phagocytosis وانما endocytosis
+
+312
+00:24:27,140 --> 00:24:32,480
+تمام؟ والطريقتين موجودة شوفوا ال membrane هنا لما
+
+313
+00:24:32,480 --> 00:24:37,730
+صار fusionبين ال outer membrane وبين ال cell
+
+314
+00:24:37,730 --> 00:24:41,750
+membrane تبع ال host cell والفيروس دخل إلى الداخل
+
+315
+00:24:41,750 --> 00:24:46,210
+لكن هنا دخل الفيروس من خلال ايه يا شبانات؟ من خلال
+
+316
+00:24:46,210 --> 00:24:52,530
+physical ايش يعني physical؟ هواي صلاة دخل جواها
+
+317
+00:24:52,530 --> 00:24:58,170
+الفيروس إلى داخل الخلية وبعدين بمر بعملية بنسميها
+
+318
+00:24:58,170 --> 00:25:02,190
+اللي هي ال uncoatingوالـ Uncoating هنشوف كمان شوية
+
+319
+00:25:02,190 --> 00:25:08,630
+أنه الـ physical هذه ذكية، هذه physical ذكية لأنه
+
+320
+00:25:08,630 --> 00:25:14,170
+بتحاول إنها تعمل ال pH يكون ملائم للـ Uncoating
+
+321
+00:25:14,170 --> 00:25:19,310
+لمين؟ ل .. اللي هو ال virus itself، كدا اتفقنا أنه
+
+322
+00:25:19,310 --> 00:25:24,550
+دخول ال virus إما بيكون عبر fusion، الاتحام مع ال
+
+323
+00:25:24,550 --> 00:25:27,250
+cell membrane أو عن طريق ال endocytosis
+
+324
+00:25:29,260 --> 00:25:33,940
+الـ Uncoating قلنا هو عبارة عن ربتشر أو انفجار of
+
+325
+00:25:33,940 --> 00:25:36,840
+the vesicle أو fusion of the outer layer of the
+
+326
+00:25:36,840 --> 00:25:39,560
+virus with the vesicle membrane deposits the inner
+
+327
+00:25:39,560 --> 00:25:43,360
+core المحصلة النهائية للـ Uncoating أنه المادة
+
+328
+00:25:43,360 --> 00:25:47,520
+الوراثية هتخرج من مين؟ من ال .. ال .. ال .. ال
+
+329
+00:25:47,520 --> 00:25:52,120
+capsid تبعت الفيروس وقلنا أن ال low pH ال .. ال pH
+
+330
+00:25:52,120 --> 00:25:56,520
+المنخفض الحامضي في ال vesicle بي .. بي .. بيساعد
+
+331
+00:25:56,520 --> 00:25:58,500
+على اللي هو ال uncoating
+
+332
+00:26:04,260 --> 00:26:08,500
+التلات خطوات اللي ذكرناهم Attachment Penetration
+
+333
+00:26:08,500 --> 00:26:14,620
+Uncoating هم تلات events ماشيين مع بعض يعني غالبا
+
+334
+00:26:14,620 --> 00:26:17,900
+بيصير فيه ارتباط و بعدين دخول و بعدين اللي هو
+
+335
+00:26:17,900 --> 00:26:22,520
+Uncoating فبنوجف عند حاجة غريبة مختلفة شوية عما
+
+336
+00:26:22,520 --> 00:26:27,580
+درسناها في الخطوات السابقة متعلق ببعض الفيروسات
+
+337
+00:26:27,580 --> 00:26:29,300
+اللي هي مرتبطة بالبكتيريا اللي بيسميها
+
+338
+00:26:29,300 --> 00:26:35,730
+Bacteriophagesالبكتيريوفاج لا بيصيرله fusion ولا
+
+339
+00:26:35,730 --> 00:26:40,110
+بيصيرله endocytosis طب هاي إيش بيعمل؟ طريقة تالتة
+
+340
+00:26:40,110 --> 00:26:45,230
+الطريقة التالتة إنه الفيروس نفسه بيجف على الخلية
+
+341
+00:26:45,230 --> 00:26:52,750
+من برا وبيحقن المادة الوراثية من خلال إحداث ثقب في
+
+342
+00:26:52,750 --> 00:26:56,950
+ال cell wall تبع البكتيريا من خلال إنزيم اسمه
+
+343
+00:26:56,950 --> 00:26:58,930
+lysozyme
+
+344
+00:27:00,390 --> 00:27:04,370
+الـ Tail Fiber تبعته هي الـ Receptor وفيه قرص Disk
+
+345
+00:27:04,370 --> 00:27:09,310
+لما بيجي على البكتيريا من ال disk بينزل الإنزيم،
+
+346
+00:27:09,310 --> 00:27:14,130
+الإنزيم بيدوب أو بيوذيب اللي هو ال cell wall
+
+347
+00:27:14,130 --> 00:27:19,150
+وبيبدأ بعملية contraction للـ Tail Fiber أو عفوا
+
+348
+00:27:19,150 --> 00:27:24,460
+لل cooler تبعتهفبيجيب ال DNA تبعه من رأسه اللي هو
+
+349
+00:27:24,460 --> 00:27:28,160
+من الرأس تبع ال .. ال .. ال .. وبيحقنه داخل اللي
+
+350
+00:27:28,160 --> 00:27:32,780
+هو ك injection بالظبط كحقنة بيحقن ال DNA لداخل
+
+351
+00:27:32,780 --> 00:27:36,680
+اللي هو ال bacteria إذا ال bacteriophage مختلفة
+
+352
+00:27:36,680 --> 00:27:41,080
+شوية عن مين عن ال other ال animal virus وهذه ممكن
+
+353
+00:27:41,080 --> 00:27:44,440
+صورة كرتونية و هتاخد وقت شوية لما تشتغل لكن هذا هو
+
+354
+00:27:44,440 --> 00:27:47,260
+ال bacteriophage فرصة نتكلم عنه هذا الرأس هذا
+
+355
+00:27:47,260 --> 00:27:52,470
+المادة الوراثية هذا اللي كنت الآنالالتقاء لحظه لما
+
+356
+00:27:52,470 --> 00:27:56,170
+بيلتقي مع ال receptors بينزل هذا ال disk بيحلل
+
+357
+00:27:56,170 --> 00:28:00,350
+اللي هو ال cell wall و بيبدأ يحكم من المادة
+
+358
+00:28:00,350 --> 00:28:03,530
+الوراثية طبعا هذه الصورة بتوضح كل الخطوات تبع ال
+
+359
+00:28:03,530 --> 00:28:07,590
+ال ال replication بس أنا معنى فقط بال .. بال ..
+
+360
+00:28:07,590 --> 00:28:12,360
+بال .. بالجزء المتعلق بمينبإدخال المادة الوراثية
+
+361
+00:28:12,360 --> 00:28:16,680
+لأنه مختلف تماما عن ال animal virus لم يكن هناك
+
+362
+00:28:16,680 --> 00:28:22,180
+حاجة للفيروس أن يدخل إلى داخل الخلية وإنما أدخل من
+
+363
+00:28:22,180 --> 00:28:27,960
+المادة الوراثية وبقي هو كصدفة فارغة لا تحتوي على
+
+364
+00:28:27,960 --> 00:28:30,920
+شيء يعني ميت مائل وأي قيمة في الخارج
+
+365
+00:28:36,370 --> 00:28:40,850
+إذن نسترجع مع بعض وين وصلنا؟ وصلنا للـ Attachment
+
+366
+00:28:40,850 --> 00:28:44,130
+و الـ Penetration و الـ Uncoating الآن بدنا ننتقل
+
+367
+00:28:44,130 --> 00:28:48,250
+أكيد لمرحلة اللي هو الـ Early Viral mRNA Synthesis
+
+368
+00:28:48,250 --> 00:28:52,470
+و الـ Early Viral Protein Synthesis Gene
+
+369
+00:28:52,470 --> 00:28:55,970
+Expression and Genome Replication كلمة Gene
+
+370
+00:28:55,970 --> 00:29:02,970
+Expression ماذا تعني؟ أن الجين يعبر عنهبالبروتين
+
+371
+00:29:02,970 --> 00:29:08,610
+من خلال ترجمة من خلال ال transcription ل mRNA ومن
+
+372
+00:29:08,610 --> 00:29:13,050
+ثم إلى البروتين إذا الجين اللي هو ال DNA يتحول إلى
+
+373
+00:29:13,050 --> 00:29:17,990
+mRNA ثم يتحول إلى البروتين إذا تحول لبروتين بنقول
+
+374
+00:29:17,990 --> 00:29:25,240
+تم التعبير عن الجينلما بنقول genome replication،
+
+375
+00:29:25,240 --> 00:29:30,040
+المادة الوراثية الأصلية تتكاثر،
+
+376
+00:29:30,040 --> 00:29:34,140
+تنقسم، يعني بدل ما كان نسخة واحدة، صار عندي مئات
+
+377
+00:29:34,140 --> 00:29:39,040
+نسخ تمهيدا لتعبيئتها في الكبسيط، إذا في اختلاف بين
+
+378
+00:29:39,040 --> 00:29:44,780
+gene expression وبين genome replication The first
+
+379
+00:29:44,780 --> 00:29:48,760
+step in viral gene expression is mRNA synthesis
+
+380
+00:29:49,470 --> 00:29:52,750
+وهذا كلام معروف، إذا بتعبر عن الـG لازم يطلع عندنا
+
+381
+00:29:52,750 --> 00:29:57,770
+mRNA، طب إذا كان الجينوم هو نفسه mRNA، مش إحنا كنا
+
+382
+00:29:57,770 --> 00:30:03,770
+فيه فيروسات، المادة اللي وراتيه تبعتها هي RNA، إيه
+
+383
+00:30:03,770 --> 00:30:10,460
+بتصير؟هذا عشان .. عشان نصنع منها اللي هي ال genome
+
+384
+00:30:10,460 --> 00:30:15,040
+تبعها بس عشان نعملها expression في بعض .. في بعض
+
+385
+00:30:15,040 --> 00:30:21,080
+الفيروسات المادة الوراثية نفسها بتكون هي ال .. ال
+
+386
+00:30:21,080 --> 00:30:25,580
+.. النسخة اللي بنشتغل عليها translation يعني على
+
+387
+00:30:25,580 --> 00:30:31,010
+طول بنترجمها لمين؟ ل .. ل proteinلكن بشكل عام إذا
+
+388
+00:30:31,010 --> 00:30:33,810
+ما نتحدث عن الفيروسات مش كلها بشكل عام نقول إنه
+
+389
+00:30:33,810 --> 00:30:37,830
+هذه العملية بتعتمد على شغلتين أساسيتين the nature
+
+390
+00:30:37,830 --> 00:30:41,590
+of their nucleic acid the part of the cell in
+
+391
+00:30:41,590 --> 00:30:46,210
+which they replicate هل بتكاثروا في النواء ولا في
+
+392
+00:30:46,210 --> 00:30:50,890
+الcytoplasm؟ وما هي المادة الوراثية؟ هل هي DNA ولا
+
+393
+00:30:50,890 --> 00:30:56,770
+RNA؟ وطبعا كمان مرة هلاجي تفاصيل عميقة جدا في
+
+394
+00:30:56,770 --> 00:31:02,380
+موضوع المادة الوراثيةأنا متعود أفهم .. أقرأ إن ال
+
+395
+00:31:02,380 --> 00:31:08,780
+mRNA هو single-strand أول كنت دراسته في التانوية
+
+396
+00:31:08,780 --> 00:31:11,940
+أو في سنة أولى أو سنة تانية في الجامعة إن ال mRNA
+
+397
+00:31:11,940 --> 00:31:15,600
+double-strandedاليوم هلاجي double strand طب في
+
+398
+00:31:15,600 --> 00:31:19,920
+double strand هل هم واحد؟ لأ أكيد complementary
+
+399
+00:31:19,920 --> 00:31:24,900
+لبعض واحد بيسميه بصي و واحد بيسميه negative و كيف
+
+400
+00:31:24,900 --> 00:31:28,120
+هذا بيشتغل و كيف هذا بيشتغل برضه كمان طريقة مختلفة
+
+401
+00:31:28,120 --> 00:31:33,460
+الحقيقة عن بعضهم البعض طيب نطلع على اللوحة دي و
+
+402
+00:31:33,460 --> 00:31:38,040
+نركز كويس لما اتكلم على ال DNA viruses و ال RNA
+
+403
+00:31:38,040 --> 00:31:43,640
+viruses نعمل محاولة تمهيدالعملية ال replication في
+
+404
+00:31:43,640 --> 00:31:48,540
+اتنين ال DNA viruses consist of double-stranded
+
+405
+00:31:48,540 --> 00:31:54,340
+DNA except for the barvo virus which is a single
+
+406
+00:31:54,340 --> 00:31:59,580
+-stranded DNA إذا كل ال DNA viruses are double
+
+407
+00:31:59,580 --> 00:32:04,920
+-stranded ما عدا ال barvo viruses عبارة عن single
+
+408
+00:32:04,920 --> 00:32:10,980
+-stranded DNA ما أظن نتعامل معه ك double-stranded
+
+409
+00:32:11,630 --> 00:32:16,190
+بينما ال RNA viruses they consist of single
+
+410
+00:32:16,190 --> 00:32:20,670
+-stranded RNA except for the members of the Rio
+
+411
+00:32:20,670 --> 00:32:25,170
+family which have double-stranded RNA جينوم خدوا
+
+412
+00:32:25,170 --> 00:32:29,710
+بالكوا الفروقات هذه كتير مهمة وال exceptions برضه
+
+413
+00:32:29,710 --> 00:32:33,750
+مهمة يعني اللوحة هذه كويسة في الامتحان يعني ممكن
+
+414
+00:32:33,750 --> 00:32:38,630
+نجيب منها نص الامتحان من اللوحة ديش رأيكم؟هي ريتها
+
+415
+00:32:38,630 --> 00:32:45,330
+هتحفظوها و خلاص او تحطوها على الجوالة طيب كمان مرة
+
+416
+00:32:45,330 --> 00:32:48,450
+كل ال DNA viruses are double-stranded معادة ال
+
+417
+00:32:48,450 --> 00:32:53,150
+Parvo virus و كل ال RNA single-stranded معادة ال
+
+418
+00:32:53,150 --> 00:32:56,390
+Rio virus which have double-stranded RNA ال
+
+419
+00:32:56,390 --> 00:33:02,530
+Rotavirus أحد الأمثلة الشهيرة على ال Rio virus
+
+420
+00:33:02,530 --> 00:33:04,750
+family ايش هو ال Rotavirus؟
+
+421
+00:33:07,590 --> 00:33:12,290
+الروتا فيروس أحد مسببات الإسهال لدى الأطفال في
+
+422
+00:33:12,290 --> 00:33:17,050
+معظم أنحاء العالم وحديثا في غزة أعتقد دخلوله
+
+423
+00:33:17,050 --> 00:33:21,870
+vaccine دخلوله vaccine للروتا فيروس طبعا الروتا
+
+424
+00:33:21,870 --> 00:33:24,950
+فيروس ماكانش معروف بالنسبة لنا في غزة أنا وجدش
+
+425
+00:33:24,950 --> 00:33:28,290
+نسابه غير كام من دراسة صارت في غزة من طلبة ملستير
+
+426
+00:33:28,290 --> 00:33:33,710
+وبعضها أظهر أنه من عشرة لخمستاش بالمائة من حالات
+
+427
+00:33:33,710 --> 00:33:39,980
+الدياريةفي الأطفال is caused by this virus فهذا أو
+
+428
+00:33:39,980 --> 00:33:44,880
+هذه النتائج اتجعلت من صناعة القرار يفكروا في واحد
+
+429
+00:33:44,880 --> 00:33:49,400
+ادخال فحوصات سيرولوجية للستول دروتا فيروس ويدعوتوا
+
+430
+00:33:49,400 --> 00:33:53,260
+يفكروا في موضوع اللي هو ال vaccine production طيب
+
+431
+00:33:53,260 --> 00:33:58,840
+ال DNA viruses they replicate in the nucleus بتكتر
+
+432
+00:33:58,840 --> 00:34:02,320
+وين؟وشوفنا ال adenovirus جاب شوية ال adenovirus
+
+433
+00:34:02,320 --> 00:34:07,620
+الرسم تبعتنا شفناه وين؟ في ال nucleus and uses the
+
+434
+00:34:07,620 --> 00:34:11,380
+host DNA dependent RNA polymerase to synthesize
+
+435
+00:34:11,380 --> 00:34:12,340
+their mRNA
+
+436
+00:34:18,580 --> 00:34:23,740
+ومنها مين ال DNA dependent RNA لعملية ال synthesis
+
+437
+00:34:23,740 --> 00:34:29,420
+لل MRNA يعني بيجيبوش معاهم specific enzymes لأ
+
+438
+00:34:29,420 --> 00:34:34,820
+بيستغلوا ال enzymes اللي موجودة مثال على exception
+
+439
+00:34:34,820 --> 00:34:39,520
+احنا قولنا كويس و اين بتكلمت على همها؟ في ال
+
+440
+00:34:39,520 --> 00:34:43,080
+nucleus ال virus بوكس هم ال exception لأنهم
+
+441
+00:34:43,080 --> 00:34:47,480
+يتعاملون في ال cytoplasmفيش شيء كله كامل وانا
+
+442
+00:34:47,480 --> 00:34:50,680
+قلتلكم من البداية اللي يدرس معانا micro لازم يكون
+
+443
+00:34:50,680 --> 00:34:57,440
+مستعد لمين؟ للاستثناءات والاستثناءات هيقد تكون
+
+444
+00:34:57,440 --> 00:35:04,020
+صعبة عند البعض، لكن قد تكون فرصة لمعرفة أو تمييز
+
+445
+00:35:04,020 --> 00:35:08,540
+بعض الفيروسات عن بعضها البعض من خلال هذا الاستثناء
+
+446
+00:35:08,540 --> 00:35:11,920
+اللي احنا بنتكلم عنه، إذن ال box virus هو الوحيد
+
+447
+00:35:11,920 --> 00:35:15,640
+من ال DNA فيروس اللي بتكاثر وين؟ في ال cytoplasm،
+
+448
+00:35:15,640 --> 00:35:22,620
+كلهم بتكاثر في ال nucleus where they do not have
+
+449
+00:35:22,620 --> 00:35:27,350
+access to the host's RNA polymeraseطبعا كونها مردف
+
+450
+00:35:27,350 --> 00:35:31,350
+انه يبقى لام تستطيع الحصول علي مين علي ال DNA
+
+451
+00:35:31,350 --> 00:35:35,130
+dependent RNA polymerase تبع الخلية فمضطرة هذه
+
+452
+00:35:35,130 --> 00:35:40,630
+الفيروسات ان هتجيب معاها their own polymerase وصل
+
+453
+00:35:40,630 --> 00:35:44,390
+الصورة و تذكروا الكلام كويس لإنه هيلزمنا كمان شوية
+
+454
+00:35:44,390 --> 00:35:50,050
+اللي بتضطر يجيب معاه انزيمات هذا مشكلةأما اللي
+
+455
+00:35:50,050 --> 00:35:55,110
+بيجي بدون أنزيمات هذا عنده ميزة أو أفضلية وحنتكلم
+
+456
+00:35:55,110 --> 00:36:00,190
+عنها جونة لاحقا نرجع لل RNA viruses كلهم single
+
+457
+00:36:00,190 --> 00:36:04,610
+-stranded ما عدا الريو فيروس واخدنا مثال جونة
+
+458
+00:36:04,610 --> 00:36:09,890
+الروتا فيروس they all replicate in the cytoplasm
+
+459
+00:36:09,890 --> 00:36:15,200
+ما عدا اتنينمشهورين برضه اللي هم ال retro viruses
+
+460
+00:36:15,200 --> 00:36:20,240
+و ال influenza virus ال retro اللي هي بتمثل مثال
+
+461
+00:36:20,240 --> 00:36:24,440
+عليها ال aids ال HIV virus و ال influenza هي
+
+462
+00:36:24,440 --> 00:36:28,340
+الشهيرة و أشهر من ان احنا نعرفها بحاجة تانية both
+
+463
+00:36:28,340 --> 00:36:31,380
+of which have an important replicative steps in
+
+464
+00:36:31,380 --> 00:36:37,820
+the nucleusلا أقول إن كل الـreplication في وين؟ في
+
+465
+00:36:37,820 --> 00:36:42,680
+الـNucleus بالنسبة للـRetro-Influenza ولكن لديها
+
+466
+00:36:42,680 --> 00:36:46,320
+خطوات مهمة في الـreplication في الـNucleus يعني
+
+467
+00:36:46,320 --> 00:36:50,180
+فيه جزء هيكون في الـCytoplasm و جزء وين؟ في النوم
+
+468
+00:36:50,180 --> 00:36:55,860
+الـRetrovirus integrate a DNA copy of their genome
+
+469
+00:36:55,860 --> 00:36:59,750
+into the host cell DNAوهذا معروف عن الـ AIDS ان
+
+470
+00:36:59,750 --> 00:37:04,990
+الـ AIDS بيدخل جزء من الجينوم تبعه جوا الجينوم تبع
+
+471
+00:37:04,990 --> 00:37:09,630
+ال host cell هذا طبعا الجينوم هو الموجود في النواء
+
+472
+00:37:09,630 --> 00:37:12,490
+و لفسته بلازم في النواء وبالتالي هو لازم يروح على
+
+473
+00:37:12,490 --> 00:37:17,700
+النواء عشان يعمل integration للجينوم تبعهبينما ال
+
+474
+00:37:17,700 --> 00:37:22,240
+influenza viruses synthesize their progeny طبعا
+
+475
+00:37:22,240 --> 00:37:25,960
+فاهمين شون برجني؟ برجني يعني السلالة، السلالة أو
+
+476
+00:37:25,960 --> 00:37:30,420
+ما ينتج من الأبناء من الفيروس، their progeny
+
+477
+00:37:30,420 --> 00:37:33,240
+genomes in the nucleus يبقى ال influenza بتطلع
+
+478
+00:37:33,240 --> 00:37:38,650
+المادة الوراثية تبعتها من النوةIn addition the
+
+479
+00:37:38,650 --> 00:37:43,270
+mRNA of hepatitis delta virus فاكرين ال delta
+
+480
+00:37:43,270 --> 00:37:45,610
+virus اللي أخطأنا في المحاضرة السابقة لما قلنا ال
+
+481
+00:37:45,610 --> 00:37:48,790
+defective virus؟ ال defective virus بدو إيش مقال
+
+482
+00:37:48,790 --> 00:37:54,340
+له هذا؟ بدو helper virusis also synthesized in the
+
+483
+00:37:54,340 --> 00:37:59,060
+nucleus of hepatocytes إذن تلت أمثلة Retrovirus و
+
+484
+00:37:59,060 --> 00:38:02,420
+Influenza بالاضافة إلى مين إلى الـ Hepatitis Delta
+
+485
+00:38:02,420 --> 00:38:07,060
+Virus من الـRNA Viruses اللي بيتكاثروا داخل اللي
+
+486
+00:38:07,060 --> 00:38:12,320
+هو النواوذ الباجي في الـCytoplasm عكس الـDNA Virus
+
+487
+00:38:12,320 --> 00:38:21,410
+ما الذي نفهمه من هذه اللوحة أن مكانالتكاثر تمام
+
+488
+00:38:21,410 --> 00:38:26,850
+اما النواء او الـ cytoplasm او ان هناك البعض
+
+489
+00:38:26,850 --> 00:38:36,050
+بيستغل النواء و الـ cytoplasm لا يوجد قاعدة محددة
+
+490
+00:38:37,190 --> 00:38:41,230
+في ال .. الفيروسات وجدنا انه من .. من ال DNA
+
+491
+00:38:41,230 --> 00:38:45,830
+viruses واحد اللي بيحب وين يتكاثر في ال cytoplasm
+
+492
+00:38:45,830 --> 00:38:50,410
+و الباقيين كلهم في اللي هو ال .. ال nucleus بينما
+
+493
+00:38:50,410 --> 00:38:54,170
+في ال RNA viruses كلهم في ال .. في ال cytoplasm
+
+494
+00:38:54,170 --> 00:38:57,150
+معدى استثناءات بسيطة في اللي هو ال nucleus
+
+495
+00:38:59,970 --> 00:39:02,370
+هذه اللوحة بتوضح لنا ما يسمى بال replication
+
+496
+00:39:02,370 --> 00:39:07,290
+strategies وانا عندي صور أكتر أوضح منها ان شاء
+
+497
+00:39:07,290 --> 00:39:11,730
+الله هوريكم معاها ناخد فكرة عامة عن ال double
+
+498
+00:39:11,730 --> 00:39:18,750
+stranded DNA viruses دخل الفيروس وانراح على النوة
+
+499
+00:39:18,750 --> 00:39:21,950
+تمام؟ اللي هم بتطلع ايه المعرنية اللي المعرنية
+
+500
+00:39:21,950 --> 00:39:24,050
+اللي هم بتروح؟ ال cytoplasm لما احنا نسيرله
+
+501
+00:39:24,050 --> 00:39:24,790
+translation
+
+502
+00:39:29,230 --> 00:39:32,070
+الـ Early Protein بترجع على النوية و بيصير فيها
+
+503
+00:39:32,070 --> 00:39:35,670
+عملية DNA Replication و ممكن يصير انها لاية جنة
+
+504
+00:39:35,670 --> 00:39:38,810
+اللي هو Transcription و Translation اللي ساميها
+
+505
+00:39:38,810 --> 00:39:46,950
+أنا سكندري بعدين بتكونة Structural Proteins اللي
+
+506
+00:39:46,950 --> 00:39:51,710
+هي ال .. ال capsids و بعدين بيصير فيها عملية جنة
+
+507
+00:39:51,710 --> 00:39:56,770
+انتقال او Packagingاللي هي في المنطقة هاي صار فيه
+
+508
+00:39:56,770 --> 00:40:02,710
+packaging للفيروس فيه الكبسيد ومن ثم ال release
+
+509
+00:40:02,710 --> 00:40:05,690
+اللي هي double stranded عن ان الفيروس عادة مرة
+
+510
+00:40:05,690 --> 00:40:08,650
+أخرى بس بدون كلام نتطلع عليها
+
+511
+00:40:47,970 --> 00:40:57,710
+الان single-stranded DNA viruses طلوا عليها برضه
+
+512
+00:40:57,710 --> 00:41:05,950
+روحنا على وين ال single
+
+513
+00:41:05,950 --> 00:41:11,220
+-stranded اتحول لمين ل double-strandedالفيروسات
+
+514
+00:41:11,220 --> 00:41:15,120
+ليست غبية بأن تغامر بالنسخة الأصلية تبعتها تعمل
+
+515
+00:41:15,120 --> 00:41:19,920
+دائما copies و بتشتري عليها ال copies كقوالب للشغل
+
+516
+00:41:19,920 --> 00:41:25,960
+تبعها تجريبا نفس ال double stranded اللهم انه في
+
+517
+00:41:25,960 --> 00:41:29,940
+إضافة خطوة إضافية يومهلة خطوة إضافية ان ال single
+
+518
+00:41:29,940 --> 00:41:34,460
+stranded تحول إلى double stranded و ال double
+
+519
+00:41:34,460 --> 00:41:39,840
+stranded بينتسخ منه نسخة بتصير قالب لتصنيع مناللي
+
+520
+00:41:39,840 --> 00:41:42,680
+هو الـ Genome الأصلي اللي هو Single Stranded كمان
+
+521
+00:41:42,680 --> 00:41:42,940
+مرة
+
+522
+00:42:11,770 --> 00:42:14,550
+هي بده double strand لمين لا single strand كمان
+
+523
+00:42:14,550 --> 00:42:20,330
+مرة عشان نصنع جينوم جديد
+
+524
+00:42:20,330 --> 00:42:27,070
+طيب نحاول انه نغطي لوحده ان شاء الله و بعدين ننهي
+
+525
+00:42:27,070 --> 00:42:31,830
+محاضرتنا اليوم strategies of mRNA synthesizing in
+
+526
+00:42:31,830 --> 00:42:36,310
+RNA viruses mRNA synthesizing in RNA virusThe
+
+527
+00:42:36,310 --> 00:42:40,370
+simplest strategy is illustrated by poliovirus،
+
+528
+00:42:40,370 --> 00:42:42,610
+الـ poliovirus اللي يقول عنه مراد فيروس شلل
+
+529
+00:42:42,610 --> 00:42:46,770
+للأطفال، which has a single-stranded RNA of
+
+530
+00:42:46,770 --> 00:42:51,410
+positive polarity، single-stranded positive
+
+531
+00:42:51,410 --> 00:42:54,850
+polarity، إيش معنى positive polarity؟ عكسه هيكون
+
+532
+00:42:54,850 --> 00:42:58,110
+إيش طبعا، negative polarity، وباختصارا بيقولها
+
+533
+00:42:58,110 --> 00:43:01,940
+positive strand و negative strandالـ Postive
+
+534
+00:43:01,940 --> 00:43:06,120
+Strand هو الـ Strand اللي جاهز انه يشتغل ك mRNA
+
+535
+00:43:06,120 --> 00:43:13,440
+مباشرة وصلت ولا مصلتش يعني لو انا عندي two strands
+
+536
+00:43:13,440 --> 00:43:17,380
+من
+
+537
+00:43:17,380 --> 00:43:24,090
+mRNA هذا strand وهذا strand كويس؟اللي فيهم already
+
+538
+00:43:24,090 --> 00:43:30,070
+بيركب عليه ال ribosome وبيترجمه هذا اسمه positive
+
+539
+00:43:30,070 --> 00:43:34,990
+strand اللي بحاجة ان يصيرله complementary strand
+
+540
+00:43:34,990 --> 00:43:38,450
+عشان يصيرله translation هذا بيسميه negative strand
+
+541
+00:43:38,450 --> 00:43:41,270
+إذا فينا positive polarity و negative polarity
+
+542
+00:43:41,270 --> 00:43:46,010
+ومفهومهم كمان مرة ال positive polarity can act as
+
+543
+00:43:46,010 --> 00:43:49,870
+an mRNA مباشرة بينما ال negative polarity محتاج
+
+544
+00:43:49,870 --> 00:43:51,490
+إلى خطوة إضافية
+
+545
+00:43:56,410 --> 00:44:02,110
+طلعوا، these viruses uses او use their RNA genome
+
+546
+00:44:02,110 --> 00:44:07,710
+directly as mRNA، هذه أبسط استراتيجية وموجودة في
+
+547
+00:44:07,710 --> 00:44:11,570
+مين؟ في الـ Polio virus. The second group has a
+
+548
+00:44:11,570 --> 00:44:15,290
+single-stranded RNA of negative polarity as its
+
+549
+00:44:15,290 --> 00:44:20,600
+genetic material.هدولة بالتأكيد الاستراتيجية
+
+550
+00:44:20,600 --> 00:44:24,320
+تبعتهم هتكون عبارة عن ايه يا شبنات؟ عبارة عن تكوين
+
+551
+00:44:24,320 --> 00:44:31,260
+complementary strand اللي هو هيكون a messenger RNA
+
+552
+00:44:31,260 --> 00:44:35,920
+بس مش مباشرة و هاد الفرق بين اللي هو ال positive و
+
+553
+00:44:35,920 --> 00:44:39,940
+ال single strand there are two sub categories of
+
+554
+00:44:39,940 --> 00:44:46,520
+negative polarity RNA virusesطبعا هذه العملية خدوا
+
+555
+00:44:46,520 --> 00:44:51,520
+بالكوا اللي هي تحويل ال negative strand نعمله
+
+556
+00:44:51,520 --> 00:44:56,440
+positive strand مش موجودة في خلايانا فالفيروسات
+
+557
+00:44:56,440 --> 00:45:01,960
+اللي عندها negative strand لازم تجيب انزيماتها
+
+558
+00:45:01,960 --> 00:45:06,580
+الخاصة فيها اللي بتحول ال negative إلى positive
+
+559
+00:45:06,580 --> 00:45:10,880
+هذه كمان نقطة كتير مهمةاللي ماعندوش access
+
+560
+00:45:10,880 --> 00:45:15,300
+لإنزيماتنا، بده يجيب إنزيماته معاه، اللي ماعنداش
+
+561
+00:45:15,300 --> 00:45:19,400
+إنزيمات أصلا للخطوة تبعته، بده يجيب إنزيماته معاه
+
+562
+00:45:19,400 --> 00:45:22,440
+في هذه الخلية، والمرة الجاية إن شاء الله يبنك
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..74dd35e92439fd7a65b65bb73c2f27aa74bf22c7
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/CDfXdxQfVIg_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 4822, "start": 20.82, "end": 48.22, "text": "بسم الله الرحمن الرحيم الحمد لله رب العالمين والصلاة والسلام وعلى سيدنا محمد وعلى آله وصحبه ومن ساعد ربي اليوم الدين محاضرتنا اليوم ان شاء الله بعنوان الـViral Replication وتعتبر من أهم المواضيع في الـVirology نظرا لاختلاف الطريقة التي تتكثر بها الفيروسات عن باق المخلوقات وللاختلاف الداخلي بين هذه الفيروسات يعني", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 21542, 2304, 3215, 24976, 3224, 12602, 3555, 18863, 45340, 9957, 16070, 9381, 15040, 3660, 16070, 3794, 37440, 4032, 3615, 23942, 8608, 25708, 8315, 3714, 35571, 3215, 4032, 3615, 23942, 19753, 43761, 4032, 9381, 5016, 3555, 3224, 4032, 27842, 8608, 995, 22488, 12602, 21292, 45595, 20498, 32748, 9957, 3714, 5016, 46958, 43500, 8315, 45595, 20498, 16472, 13412, 16606, 21984, 45030, 1863, 2407, 7649, 2423, 39184, 53, 35083, 1300, 4770, 399, 34683, 34268, 26890, 9154, 5551, 16095, 9673, 2407, 46958, 40228, 8978, 2423, 39184, 53, 5182, 4987, 88, 8717, 19913, 23557, 5296, 47283, 2655, 15040, 5172, 41950, 16572, 28671, 38392, 6055, 2655, 4117, 49115, 4724, 11296, 27188, 13546, 41779, 9307, 18871, 4724, 995, 4587, 9673, 9778, 1211, 30543, 9307, 4032, 1211, 1211, 47283, 2655, 15040, 5172, 32748, 47283, 20292, 49374, 29538, 27188, 13546, 41779, 9307, 37495, 22653], "avg_logprob": -0.12273707060978331, "compression_ratio": 1.93006993006993, "no_speech_prob": 2.205371856689453e-06, "words": [{"start": 20.82, "end": 21.06, "word": "بسم", "probability": 0.877685546875}, {"start": 21.06, "end": 21.2, "word": " الله", "probability": 0.94970703125}, {"start": 21.2, "end": 21.5, "word": " الرحمن", "probability": 0.9549153645833334}, {"start": 21.5, "end": 21.78, "word": " الرحيم", "probability": 0.9934895833333334}, {"start": 21.78, "end": 22.08, "word": " الحمد", "probability": 0.88720703125}, {"start": 22.08, "end": 22.26, "word": " لله", "probability": 0.931396484375}, {"start": 22.26, "end": 22.44, "word": " رب", "probability": 0.93603515625}, {"start": 22.44, "end": 22.78, "word": " العالمين", "probability": 0.9928385416666666}, {"start": 22.78, "end": 23.1, "word": " والصلاة", "probability": 0.84661865234375}, {"start": 23.1, "end": 23.48, "word": " والسلام", "probability": 0.9490559895833334}, {"start": 23.48, "end": 23.76, "word": " وعلى", "probability": 0.8551432291666666}, {"start": 23.76, "end": 24.1, "word": " سيدنا", "probability": 0.98193359375}, {"start": 24.1, "end": 24.54, "word": " محمد", "probability": 0.97802734375}, {"start": 24.54, "end": 24.72, "word": " وعلى", "probability": 0.9462890625}, {"start": 24.72, "end": 24.98, "word": " آله", "probability": 0.8701171875}, {"start": 24.98, "end": 25.54, "word": " وصحبه", "probability": 0.923046875}, {"start": 25.54, "end": 25.82, "word": " ومن", "probability": 0.9755859375}, {"start": 25.82, "end": 26.12, "word": " ساعد", "probability": 0.978515625}, {"start": 26.12, "end": 26.34, "word": " ربي", "probability": 0.93896484375}, {"start": 26.34, "end": 26.56, "word": " اليوم", "probability": 0.6827392578125}, {"start": 26.56, "end": 26.88, "word": " الدين", "probability": 0.965576171875}, {"start": 26.88, "end": 29.1, "word": " محاضرتنا", "probability": 0.86083984375}, {"start": 29.1, "end": 29.26, "word": " اليوم", "probability": 0.984130859375}, {"start": 29.26, "end": 29.4, "word": " ان", "probability": 0.54931640625}, {"start": 29.4, "end": 29.5, "word": " شاء", "probability": 0.975830078125}, {"start": 29.5, "end": 29.52, "word": " الله", "probability": 0.9482421875}, {"start": 29.52, "end": 30.06, "word": " بعنوان", "probability": 0.9443359375}, {"start": 30.06, "end": 31.6, "word": " الـViral", "probability": 0.5333251953125}, {"start": 31.6, "end": 32.42, "word": " Replication", "probability": 0.8134765625}, {"start": 32.42, "end": 33.94, "word": " وتعتبر", "probability": 0.8463541666666666}, {"start": 33.94, "end": 34.12, "word": " من", "probability": 0.994140625}, {"start": 34.12, "end": 34.56, "word": " أهم", "probability": 0.935791015625}, {"start": 34.56, "end": 35.96, "word": " المواضيع", "probability": 0.9783935546875}, {"start": 35.96, "end": 36.3, "word": " في", "probability": 0.98486328125}, {"start": 36.3, "end": 37.68, "word": " الـVirology", "probability": 0.8145751953125}, {"start": 37.68, "end": 38.36, "word": " نظرا", "probability": 0.9562174479166666}, {"start": 38.36, "end": 39.84, "word": " لاختلاف", "probability": 0.894140625}, {"start": 39.84, "end": 40.92, "word": " الطريقة", "probability": 0.9923502604166666}, {"start": 40.92, "end": 41.32, "word": " التي", "probability": 0.9140625}, {"start": 41.32, "end": 41.8, "word": " تتكثر", "probability": 0.862060546875}, {"start": 41.8, "end": 42.0, "word": " بها", "probability": 0.91015625}, {"start": 42.0, "end": 42.78, "word": " الفيروسات", "probability": 0.9627685546875}, {"start": 42.78, "end": 43.28, "word": " عن", "probability": 0.9853515625}, {"start": 43.28, "end": 43.56, "word": " باق", "probability": 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"probability": 0.29638671875}, {"start": 487.77, "end": 487.93, "word": " في", "probability": 0.86669921875}, {"start": 487.93, "end": 488.13, "word": " عندي", "probability": 0.8369140625}, {"start": 488.13, "end": 488.43, "word": " فترة", "probability": 0.9977213541666666}, {"start": 488.43, "end": 489.29, "word": " اختفاء", "probability": 0.946533203125}, {"start": 489.29, "end": 489.71, "word": " لا", "probability": 0.75830078125}, {"start": 489.71, "end": 490.17, "word": " أستطيع", "probability": 0.8973388671875}, {"start": 490.17, "end": 490.57, "word": " قياس", "probability": 0.9609375}, {"start": 490.57, "end": 491.07, "word": " الفيروس", "probability": 0.9207356770833334}, {"start": 491.07, "end": 491.53, "word": " فيها", "probability": 0.967041015625}], "temperature": 1.0}, {"id": 20, "seek": 51928, "start": 493.22, "end": 519.28, "text": "الـ cytopathic effect التعريف اللي ذكرناه وقلنالكم هو التأثير الحاصل على الخلايا التي ينمو عليها الفيروس وكونكم لسه ما اتعلمتوش كيف الفيروس أصلا بينمو وبيتكاثر في المعمل بدنا نوضحلكم مثلًا لو افترضنا هذا الجوال عبارة عن بطل شفافة ويلها عنق وغطاء", "tokens": [6027, 39184, 40248, 27212, 299, 1802, 16712, 3615, 16572, 5172, 13672, 1829, 29910, 37983, 8315, 3224, 4032, 4587, 1211, 8315, 23275, 2304, 31439, 16712, 10721, 12984, 13546, 21542, 33546, 1211, 15844, 33962, 15040, 25528, 38392, 7251, 1863, 2304, 2407, 25894, 11296, 27188, 13546, 41779, 4032, 4117, 11536, 24793, 5296, 3794, 3224, 19446, 1975, 2655, 3615, 19528, 2655, 2407, 8592, 9122, 33911, 27188, 13546, 41779, 5551, 9381, 15040, 4724, 9957, 2304, 2407, 4032, 21292, 2655, 4117, 5718, 104, 2288, 8978, 9673, 25957, 1211, 47525, 8315, 8717, 2407, 11242, 5016, 23275, 2304, 50113, 1211, 14111, 995, 45164, 1975, 5172, 2655, 43042, 8315, 23758, 25724, 2407, 6027, 6225, 3555, 9640, 3660, 18871, 4724, 9566, 1211, 13412, 5172, 31845, 3660, 4032, 26895, 11296, 18871, 4587, 4032, 17082, 9566, 16606], "avg_logprob": -0.14459325503262263, "compression_ratio": 1.75, 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"probability": 0.966796875}, {"start": 500.3, "end": 500.92, "word": " التي", "probability": 0.86376953125}, {"start": 500.92, "end": 501.3, "word": " ينمو", "probability": 0.9522705078125}, {"start": 501.3, "end": 501.76, "word": " عليها", "probability": 0.98583984375}, {"start": 501.76, "end": 502.4, "word": " الفيروس", "probability": 0.9290364583333334}, {"start": 502.4, "end": 502.96, "word": " وكونكم", "probability": 0.8021240234375}, {"start": 502.96, "end": 503.9, "word": " لسه", "probability": 0.9318033854166666}, {"start": 503.9, "end": 504.0, "word": " ما", "probability": 0.60205078125}, {"start": 504.0, "end": 504.62, "word": " اتعلمتوش", "probability": 0.8443777901785714}, {"start": 504.62, "end": 504.84, "word": " كيف", "probability": 0.979248046875}, {"start": 504.84, "end": 505.3, "word": " الفيروس", "probability": 0.9664713541666666}, {"start": 505.3, "end": 505.78, "word": " أصلا", "probability": 0.82666015625}, {"start": 505.78, "end": 507.2, "word": " بينمو", "probability": 0.887451171875}, {"start": 507.2, "end": 507.8, "word": " وبيتكاثر", "probability": 0.8869977678571429}, {"start": 507.8, "end": 507.92, "word": " في", "probability": 0.91015625}, {"start": 507.92, "end": 508.46, "word": " المعمل", "probability": 0.9928385416666666}, {"start": 508.46, "end": 509.02, "word": " بدنا", "probability": 0.6649169921875}, {"start": 509.02, "end": 509.82, "word": " نوضحلكم", "probability": 0.9547526041666666}, {"start": 509.82, "end": 511.22, "word": " مثلًا", "probability": 0.7845458984375}, {"start": 511.22, "end": 511.44, "word": " لو", "probability": 0.677734375}, {"start": 511.44, "end": 512.02, "word": " افترضنا", "probability": 0.9630859375}, {"start": 512.02, "end": 512.86, "word": " هذا", "probability": 0.95068359375}, {"start": 512.86, "end": 513.44, "word": " الجوال", "probability": 0.9466145833333334}, {"start": 513.44, "end": 514.14, "word": " عبارة", "probability": 0.9964599609375}, {"start": 514.14, "end": 514.34, "word": " عن", "probability": 0.99267578125}, {"start": 514.34, "end": 514.78, "word": " بطل", "probability": 0.9352213541666666}, {"start": 514.78, "end": 517.0, "word": " شفافة", "probability": 0.82867431640625}, {"start": 517.0, "end": 518.22, "word": " ويلها", "probability": 0.7242838541666666}, {"start": 518.22, "end": 518.62, "word": " عنق", "probability": 0.97216796875}, {"start": 518.62, "end": 519.28, "word": " وغطاء", "probability": 0.9306640625}], "temperature": 1.0}, {"id": 21, "seek": 54400, "start": 520.36, "end": 544.0, "text": "وادخلنا من هذا الغطاء مادة مغذية وادخلنا خلايا آدمية الخلايا الآدمية نفترض أنها من أي عضو من عضاء الدسم لما تتكاثر الخلايا الآدمية جوا، تتكثرش وبتكون أنه عضو، تتكاثر وبتكون طبقة سطحية mono layer طبقة واحدة من الخلايا", "tokens": [2407, 18513, 9778, 1211, 8315, 9154, 23758, 6024, 118, 9566, 16606, 3714, 18513, 3660, 3714, 17082, 8848, 10632, 4032, 18513, 9778, 1211, 8315, 16490, 15040, 25528, 19753, 40448, 10632, 33962, 15040, 25528, 6024, 95, 40448, 10632, 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0.9542643229166666}, {"start": 523.1, "end": 523.74, "word": " مغذية", "probability": 0.9271240234375}, {"start": 523.74, "end": 524.78, "word": " وادخلنا", "probability": 0.9658203125}, {"start": 524.78, "end": 525.18, "word": " خلايا", "probability": 0.9503580729166666}, {"start": 525.18, "end": 525.86, "word": " آدمية", "probability": 0.9363606770833334}, {"start": 525.86, "end": 527.4, "word": " الخلايا", "probability": 0.8929036458333334}, {"start": 527.4, "end": 527.92, "word": " الآدمية", "probability": 0.8421630859375}, {"start": 527.92, "end": 528.32, "word": " نفترض", "probability": 0.925048828125}, {"start": 528.32, "end": 528.6, "word": " أنها", "probability": 0.697021484375}, {"start": 528.6, "end": 528.84, "word": " من", "probability": 0.97705078125}, {"start": 528.84, "end": 529.56, "word": " أي", "probability": 0.841796875}, {"start": 529.56, "end": 529.8, "word": " عضو", "probability": 0.9698893229166666}, {"start": 529.8, "end": 529.96, "word": " من", "probability": 0.98193359375}, {"start": 529.96, "end": 530.22, "word": " عضاء", "probability": 0.89501953125}, {"start": 530.22, "end": 530.58, "word": " الدسم", "probability": 0.879150390625}, {"start": 530.58, "end": 531.58, "word": " لما", "probability": 0.822021484375}, {"start": 531.58, "end": 532.12, "word": " تتكاثر", "probability": 0.9120279947916666}, {"start": 532.12, "end": 532.52, "word": " الخلايا", "probability": 0.9716796875}, {"start": 532.52, "end": 533.06, "word": " الآدمية", "probability": 0.8885498046875}, {"start": 533.06, "end": 534.06, "word": " جوا،", "probability": 0.7103678385416666}, {"start": 534.06, "end": 534.64, "word": " تتكثرش", "probability": 0.8081461588541666}, {"start": 534.64, "end": 535.04, "word": " وبتكون", "probability": 0.7928873697916666}, {"start": 535.04, "end": 535.28, "word": " أنه", "probability": 0.510009765625}, {"start": 535.28, "end": 536.66, "word": " عضو،", "probability": 0.9017333984375}, {"start": 536.66, "end": 537.5, "word": " تتكاثر", "probability": 0.9513346354166666}, {"start": 537.5, "end": 538.12, "word": " وبتكون", "probability": 0.84326171875}, {"start": 538.12, "end": 538.7, "word": " طبقة", "probability": 0.97314453125}, {"start": 538.7, "end": 539.48, "word": " سطحية", "probability": 0.9945068359375}, {"start": 539.48, "end": 540.12, "word": " mono", "probability": 0.44580078125}, {"start": 540.12, "end": 541.04, "word": " layer", "probability": 0.75048828125}, {"start": 541.04, "end": 541.84, "word": " طبقة", "probability": 0.8440755208333334}, {"start": 541.84, "end": 543.02, "word": " واحدة", "probability": 0.984375}, {"start": 543.02, "end": 543.44, "word": " من", "probability": 0.99267578125}, {"start": 543.44, "end": 544.0, "word": " الخلايا", "probability": 0.9788411458333334}], "temperature": 1.0}, {"id": 22, "seek": 57016, "start": 544.94, "end": 570.16, "text": "هذا النوع من الخلايا استطيع ان افحصه تحت ال microscope و ارى ما يسمى بال normal morphology الشكل الطبيعي لهذا الخلايا تمام؟ و كل نوع خلايا له normal morphology لو وضعنا virus عليه و ال virus قلنا لكم من النوع اللي بدمر الخلايا تمام؟ بدمرها كل مرة بنفس الطريقة", "tokens": [3224, 15730, 28239, 45367, 9154, 33962, 15040, 25528, 44713, 9566, 40228, 16472, 1975, 5172, 5016, 9381, 3224, 6055, 33753, 2423, 4532, 4417, 1114, 4032, 1975, 2288, 7578, 19446, 7251, 38251, 7578, 20666, 2710, 25778, 1793, 25124, 28820, 41950, 21292, 3615, 1829, 46740, 15730, 33962, 15040, 25528, 46811, 10943, 22807, 4032, 28242, 8717, 45367, 16490, 15040, 25528, 46740, 2710, 25778, 1793, 45164, 4032, 11242, 3615, 8315, 5752, 47356, 4032, 2423, 5752, 12174, 1211, 8315, 5296, 24793, 9154, 28239, 45367, 13672, 1829, 47525, 29973, 33962, 15040, 25528, 46811, 10943, 22807, 47525, 29973, 11296, 28242, 3714, 25720, 44945, 36178, 41950, 16572, 28671], "avg_logprob": -0.15382812827825545, "compression_ratio": 1.8914027149321266, "no_speech_prob": 0.0, "words": [{"start": 544.94, "end": 545.34, "word": "هذا", "probability": 0.90576171875}, {"start": 545.34, "end": 545.64, "word": " النوع", "probability": 0.810546875}, {"start": 545.64, "end": 545.86, "word": " من", "probability": 0.951171875}, {"start": 545.86, "end": 546.48, "word": " الخلايا", "probability": 0.9482421875}, {"start": 546.48, "end": 547.24, "word": " استطيع", "probability": 0.8046875}, {"start": 547.24, "end": 547.5, "word": " ان", "probability": 0.72509765625}, {"start": 547.5, "end": 549.04, "word": " افحصه", "probability": 0.824609375}, {"start": 549.04, "end": 549.36, "word": " تحت", "probability": 0.983642578125}, {"start": 549.36, "end": 549.48, "word": " ال", "probability": 0.380859375}, {"start": 549.48, "end": 550.16, "word": " microscope", "probability": 0.7755533854166666}, {"start": 550.16, "end": 550.62, "word": " و", "probability": 0.8662109375}, {"start": 550.62, "end": 551.02, "word": " ارى", "probability": 0.7561848958333334}, {"start": 551.02, "end": 551.16, "word": " ما", "probability": 0.9326171875}, {"start": 551.16, "end": 551.6, "word": " يسمى", "probability": 0.9778645833333334}, {"start": 551.6, "end": 551.76, "word": " بال", "probability": 0.96484375}, {"start": 551.76, "end": 552.16, "word": " normal", "probability": 0.40234375}, {"start": 552.16, "end": 552.84, "word": " morphology", "probability": 0.962158203125}, {"start": 552.84, "end": 553.32, "word": " الشكل", "probability": 0.828857421875}, {"start": 553.32, "end": 554.04, "word": " الطبيعي", "probability": 0.97216796875}, {"start": 554.04, "end": 554.28, "word": " لهذا", "probability": 0.885498046875}, {"start": 554.28, "end": 554.7, "word": " الخلايا", "probability": 0.9407552083333334}, {"start": 554.7, "end": 555.92, "word": " تمام؟", "probability": 0.7316080729166666}, {"start": 555.92, "end": 556.18, "word": " و", "probability": 0.9072265625}, {"start": 556.18, "end": 556.48, "word": " كل", "probability": 0.7216796875}, {"start": 556.48, "end": 556.94, "word": " نوع", "probability": 0.977294921875}, {"start": 556.94, "end": 557.56, "word": " خلايا", "probability": 0.9363606770833334}, {"start": 557.56, "end": 557.84, "word": " له", "probability": 0.57958984375}, {"start": 557.84, "end": 558.26, "word": " normal", "probability": 0.84033203125}, {"start": 558.26, "end": 559.1, "word": " morphology", "probability": 0.976806640625}, {"start": 559.1, "end": 560.46, "word": " لو", "probability": 0.89990234375}, {"start": 560.46, "end": 560.92, "word": " وضعنا", "probability": 0.9935302734375}, {"start": 560.92, "end": 561.32, "word": " virus", "probability": 0.330322265625}, {"start": 561.32, "end": 561.76, "word": " عليه", "probability": 0.89697265625}, {"start": 561.76, "end": 562.42, "word": " و", "probability": 0.7060546875}, {"start": 562.42, "end": 562.56, "word": " ال", "probability": 0.83935546875}, {"start": 562.56, "end": 563.0, "word": " virus", "probability": 0.98095703125}, {"start": 563.0, "end": 563.4, "word": " قلنا", "probability": 0.724609375}, {"start": 563.4, "end": 563.66, "word": " لكم", "probability": 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"text": "التدمير هذا بنسميه cytopathic effect كيف ممكن أفحصه؟ مرة أخرى تحت ال microscope في عندي normal morphology وفي عندي abnormal morphology ال abnormal morphology هي ال cytopathic effect اللي احنا بنشوفه ايش ممكن نشوف؟ ممكن نشوف فجوات", "tokens": [6027, 2655, 40448, 13546, 23758, 44945, 38251, 1829, 3224, 40248, 27212, 299, 1802, 9122, 33911, 3714, 43020, 5551, 5172, 5016, 9381, 3224, 22807, 3714, 25720, 5551, 34740, 7578, 6055, 33753, 2423, 4532, 4417, 1114, 8978, 18871, 16254, 2710, 25778, 1793, 4032, 41185, 18871, 16254, 32847, 25778, 1793, 2423, 32847, 25778, 1793, 39896, 2423, 40248, 27212, 299, 1802, 13672, 1829, 1975, 5016, 8315, 44945, 8592, 38688, 3224, 1975, 1829, 8592, 3714, 43020, 8717, 8592, 38688, 22807, 3714, 43020, 8717, 8592, 38688, 6156, 7435, 2407, 9307], "avg_logprob": -0.18235293767031502, "compression_ratio": 1.7354497354497354, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 571.35, "end": 571.85, "word": "التدمير", "probability": 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عبارة عن التكاثر في ال adenovirus واحد من أكتر الفيروسات اللي دُرست فيها ال replication cycle", "tokens": [6027, 8592, 28820, 13672, 1829, 5551, 2304, 10943, 8315, 5296, 16758, 3215, 9154, 6055, 9566, 21292, 4587, 19446, 29910, 37983, 8315, 3224, 9154, 3931, 15844, 23758, 25124, 28820, 16070, 1211, 2407, 5016, 3660, 13672, 1829, 5551, 2304, 10943, 24793, 39896, 6225, 3555, 9640, 3660, 18871, 16712, 4117, 5718, 104, 2288, 8978, 2423, 614, 268, 5179, 9619, 36764, 24401, 9154, 5551, 4117, 2655, 2288, 27188, 13546, 41779, 9307, 13672, 1829, 11778, 10859, 2288, 14851, 8978, 11296, 2423, 39911, 6586], "avg_logprob": -0.13696598365337034, "compression_ratio": 1.5789473684210527, "no_speech_prob": 0.0, "words": [{"start": 936.68, "end": 937.32, "word": "الشكل", "probability": 0.9781901041666666}, {"start": 937.32, "end": 937.46, "word": " اللي", "probability": 0.719482421875}, {"start": 937.46, "end": 937.96, "word": " أمامنا", "probability": 0.8408203125}, {"start": 937.96, "end": 938.84, 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"temperature": 1.0}, {"id": 59, "seek": 145207, "start": 1434.29, "end": 1452.07, "text": "واذا بتذكروا لما شرحنالكوا ال membrane قولنالكوا هو عبارة عن viscous مش حاجة صلبة يعني سهل جدا انه يمتزج ال viscous مع ال viscous وبالتالي ال membrane مع ال membrane هيمتزجوا مع بعض والفيروس هيجعجوا الخلية", "tokens": [2407, 45636, 995, 39894, 8848, 37983, 14407, 5296, 15042, 13412, 2288, 5016, 1863, 6027, 4117, 14407, 2423, 19651, 12174, 12610, 1863, 6027, 4117, 14407, 31439, 6225, 3555, 9640, 3660, 18871, 1452, 39939, 37893, 11331, 26108, 3660, 20328, 46152, 3660, 37495, 22653, 8608, 3224, 1211, 10874, 28259, 16472, 3224, 7251, 2304, 2655, 11622, 7435, 2423, 1452, 39939, 20449, 2423, 1452, 39939, 46599, 6027, 2655, 6027, 1829, 2423, 19651, 20449, 2423, 19651, 39896, 2304, 2655, 11622, 7435, 14407, 20449, 45030, 11242, 16070, 5172, 13546, 41779, 39896, 7435, 3615, 7435, 14407, 33962, 1211, 10632], "avg_logprob": -0.16932744937746422, "compression_ratio": 1.8333333333333333, "no_speech_prob": 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DNA viruses consist of double-stranded DNA except for the barvo virus which is a single-stranded DNA إذا كل ال DNA viruses are double-stranded ما عدا ال barvo viruses عبارة عن single-stranded DNA ما أظن نتعامل معه ك double-stranded", "tokens": [6027, 25957, 1211, 10632, 2423, 39911, 8978, 1975, 2655, 1863, 9957, 2423, 8272, 21785, 4603, 295, 3834, 12, 372, 3699, 292, 8272, 3993, 337, 264, 2159, 3080, 5752, 597, 307, 257, 2167, 12, 372, 3699, 292, 8272, 11933, 15730, 28242, 2423, 8272, 21785, 366, 3834, 12, 372, 3699, 292, 19446, 6225, 28259, 2423, 2159, 3080, 21785, 6225, 3555, 9640, 3660, 18871, 2167, 12, 372, 3699, 292, 8272, 19446, 5551, 19913, 1863, 8717, 2655, 3615, 10943, 1211, 20449, 3224, 9122, 3834, 12, 372, 3699, 292], "avg_logprob": -0.22371323599534876, "compression_ratio": 1.641025641025641, "no_speech_prob": 0.0, "words": [{"start": 1901.96, "end": 1902.58, "word": "العملية", "probability": 0.8553466796875}, {"start": 1902.58, "end": 1902.7, "word": " ال", "probability": 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new file mode 100644
index 0000000000000000000000000000000000000000..ae95e633b249728d46b836f2f8ec68830d6f2973
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@@ -0,0 +1 @@
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بشكل كوريات صغيرة و بشكل filaments يبقى ال surface antigen هيكون حجمه ألاف الأضعاف بالمقارنة مع مين مع ال DNA بتاع ال virus نفسه و مع اللي هو ال other antigens لإن ال real virus بيحتوي على surface و core", "tokens": [1211, 10721, 1975, 2655, 8848, 37983, 14407, 1975, 2655, 8848, 37983, 14407, 16472, 23758, 27188, 13546, 41779, 11933, 1829, 3224, 46740, 23032, 21292, 27884, 1975, 46456, 46538, 2655, 18871, 4724, 995, 38436, 27188, 13546, 41779, 9307, 28242, 11296, 14739, 2655, 7435, 3753, 2511, 3213, 4724, 8592, 28820, 9122, 13063, 1829, 9307, 20328, 17082, 48923, 4032, 4724, 8592, 28820, 1387, 28401, 7251, 3555, 4587, 7578, 2423, 3753, 2511, 3213, 39896, 30544, 11331, 7435, 2304, 3224, 5551, 15040, 5172, 16247, 11242, 3615, 31845, 20666, 2304, 4587, 9640, 1863, 3660, 20449, 3714, 9957, 20449, 2423, 8272, 39894, 45761, 2423, 5752, 8717, 36178, 3224, 4032, 20449, 13672, 1829, 31439, 2423, 661, 44417, 694, 5296, 28814, 1863, 2423, 957, 5752, 4724, 1829, 33753, 45865, 15844, 3753, 4032, 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قلنا لكوا انه واحد الى الف يعني واحد فيروس الى الف قطعة أخرى فبالتالي بالفعل ال surface antigen ايش ماله؟ وهل وجود surface antigen يعني وجود الفيروس؟ ايش رأيكم؟", "tokens": [2407, 462, 12, 394, 3213, 49374, 15042, 2423, 1387, 28401, 4032, 2423, 41225, 13672, 1829, 11331, 4117, 1829, 8315, 18871, 16095, 8032, 2304, 13672, 1829, 4724, 1829, 33753, 2288, 4587, 14407, 6156, 47432, 15844, 3753, 2511, 3213, 4032, 12174, 1211, 8315, 5296, 4117, 14407, 16472, 3224, 36764, 24401, 2423, 7578, 27188, 37495, 22653, 36764, 24401, 8978, 32887, 3794, 2423, 7578, 27188, 12174, 9566, 27884, 5551, 34740, 7578, 6156, 3555, 6027, 2655, 6027, 1829, 20666, 5172, 30241, 2423, 3753, 2511, 3213, 1975, 1829, 8592, 3714, 6027, 3224, 22807, 37037, 1211, 49610, 23328, 3753, 2511, 3213, 37495, 22653, 49610, 23328, 27188, 13546, 41779, 22807, 1975, 1829, 8592, 12602, 10721, 1829, 24793, 22807], "avg_logprob": -0.24422859957626275, "compression_ratio": 1.8149779735682818, "no_speech_prob": 3.5762786865234375e-07, 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0.53759765625}, {"start": 2784.2, "end": 2784.36, "word": " يوم", "probability": 0.99462890625}, {"start": 2784.36, "end": 2784.68, "word": " بطلع", "probability": 0.91162109375}, {"start": 2784.68, "end": 2785.16, "word": " جديد", "probability": 0.95751953125}, {"start": 2785.16, "end": 2785.52, "word": " اللي", "probability": 0.81103515625}, {"start": 2785.52, "end": 2785.68, "word": " أنا", "probability": 0.57568359375}, {"start": 2785.68, "end": 2786.04, "word": " درسته", "probability": 0.931640625}, {"start": 2786.04, "end": 2786.14, "word": " في", "probability": 0.966796875}, {"start": 2786.14, "end": 2786.22, "word": " ال", "probability": 0.921875}, {"start": 2786.22, "end": 2786.8, "word": " immunology", "probability": 0.87548828125}, {"start": 2786.8, "end": 2787.06, "word": " لا", "probability": 0.77978515625}, {"start": 2787.06, "end": 2787.64, "word": " يساوي", "probability": 0.940673828125}, {"start": 2787.64, "end": 2788.4, "word": " واحد", "probability": 0.890869140625}, {"start": 2788.4, "end": 2788.72, "word": " على", "probability": 0.7041015625}, {"start": 2788.72, "end": 2789.4, "word": " عشرين", "probability": 0.9646809895833334}, {"start": 2789.4, "end": 2789.52, "word": " او", "probability": 0.817626953125}, {"start": 2789.52, "end": 2790.12, "word": " تلاتين", "probability": 0.962158203125}, {"start": 2790.12, "end": 2790.64, "word": " من", "probability": 0.98193359375}, {"start": 2790.64, "end": 2790.78, "word": " اللي", "probability": 0.983154296875}, {"start": 2790.78, "end": 2791.0, "word": " الآن", "probability": 0.751708984375}, {"start": 2791.0, "end": 2791.66, "word": " بندرسه", "probability": 0.9267578125}, {"start": 2791.66, "end": 2792.08, "word": " في", "probability": 0.9697265625}, {"start": 2792.08, "end": 2792.2, "word": " ال", "probability": 0.95068359375}, {"start": 2792.2, "end": 2792.86, "word": " virology", "probability": 0.744873046875}, {"start": 2792.86, "end": 2793.12, "word": " من", "probability": 0.98974609375}, {"start": 2793.12, "end": 2793.66, "word": " المناعة", "probability": 0.6998697916666666}, {"start": 2793.66, "end": 2794.98, "word": " العلم", "probability": 0.849853515625}, {"start": 2794.98, "end": 2795.58, "word": " بتتطور", "probability": 0.813720703125}, {"start": 2795.58, "end": 2795.78, "word": " و", "probability": 0.6484375}, {"start": 2795.78, "end": 2796.5, "word": " بتزداد", "probability": 0.896484375}, {"start": 2796.5, "end": 2796.92, "word": " وبالتالي", "probability": 0.93642578125}, {"start": 2796.92, "end": 2797.26, "word": " لابد", "probability": 0.7821451822916666}, {"start": 2797.26, "end": 2797.44, "word": " ان", "probability": 0.693359375}, {"start": 2797.44, "end": 2797.62, "word": " احنا", "probability": 0.8806966145833334}, {"start": 2797.62, "end": 2798.28, "word": " نتطور", "probability": 0.9864501953125}, {"start": 2798.28, "end": 2798.62, "word": " هنقدر", "probability": 0.9537353515625}, {"start": 2798.62, "end": 2798.92, "word": " نجدم", "probability": 0.7908528645833334}, {"start": 2798.92, "end": 2799.52, "word": " خدمة", "probability": 0.9798177083333334}, {"start": 2799.52, "end": 2800.3, "word": " جيدة", "probability": 0.9733072916666666}, {"start": 2800.3, "end": 2801.06, "word": " لأبناء", "probability": 0.859033203125}, {"start": 2801.06, "end": 2801.4, "word": " عشانها", "probability": 0.8349609375}, {"start": 2801.4, "end": 2801.82, "word": " شكرا", "probability": 0.8653971354166666}, {"start": 2801.82, "end": 2801.96, "word": " و", "probability": 0.2744140625}, {"start": 2801.96, "end": 2802.12, "word": " أعطيكم", "probability": 0.723388671875}, {"start": 2802.12, "end": 2802.32, "word": " ألف", "probability": 0.779052734375}, {"start": 2802.32, "end": 2802.6, "word": " عافية", "probability": 0.7786458333333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2802.9968125, "duration_after_vad": 2691.3706249999914}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/COCAScUekH8_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/COCAScUekH8_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6b9293d7183c83ed7031b0b9c4533cb7cc983428
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/COCAScUekH8_raw.srt
@@ -0,0 +1,2572 @@
+1
+00:00:21,310 --> 00:00:24,290
+بسم الله الرحمن الرحيم سنكمل ان شاء الله ما بدأنا
+
+2
+00:00:24,290 --> 00:00:29,430
+المحاضرة السابقة من Hepatitis viruses اتكلمنا
+
+3
+00:00:29,430 --> 00:00:32,810
+المحاضرة الماضية عن Hepatitis A وان شاء الله اليوم
+
+4
+00:00:32,810 --> 00:00:36,610
+هنكمل الجزء المتعلق بال pathogenesis و ال immunity
+
+5
+00:00:36,610 --> 00:00:41,390
+لل Hepatitis Bوارفنا ان الـ Hepatitis B مهم جدا
+
+6
+00:00:41,390 --> 00:00:45,730
+لأسباب متنوعة من ضمن هذه الأسباب ان نسبة ما نسبته
+
+7
+00:00:45,730 --> 00:00:51,190
+5% من المرضى المصابين يتحولوا الى chronic carriers
+
+8
+00:00:51,190 --> 00:00:54,930
+و هدول ال chronic carriers نسبة لا بأس بيها منهم
+
+9
+00:00:54,930 --> 00:00:57,950
+ايضا تتحول الى Hepatocellular Carcinoma أو
+
+10
+00:00:57,950 --> 00:01:01,890
+Hepatomaولمّا اتكلمنا عن الأرقام العالمية كنا
+
+11
+00:01:01,890 --> 00:01:05,970
+حوالي 300 مليون انسان مصابين ب chronic ماعرف احنا
+
+12
+00:01:05,970 --> 00:01:10,050
+كدش الرقم المصابين او كانوا مصابين بالهولوجيز رقم
+
+13
+00:01:10,050 --> 00:01:13,830
+هذا كبير جدا طبعا الرقم اللي بنزل في العصر الحالي
+
+14
+00:01:13,830 --> 00:01:18,810
+بنزل بشكل انحدار قوي لإنه ال vaccine عمل مفعول جيد
+
+15
+00:01:18,810 --> 00:01:22,250
+في معظم دول العالم خاصة الدول الأسوية اللي كانت
+
+16
+00:01:22,250 --> 00:01:27,690
+بتشكليعني الجزء الأكبر من المرضى في العالم ال
+
+17
+00:01:27,690 --> 00:01:30,970
+pathogenesis و ال immunity لهذا الفيروس بعد دخول
+
+18
+00:01:30,970 --> 00:01:33,970
+الفيروس إلى الدم الفيروس بيعمل infection ل ال
+
+19
+00:01:33,970 --> 00:01:36,990
+hepatocyte و بعدين ال viral antigen بيصير له
+
+20
+00:01:36,990 --> 00:01:40,710
+display على ال cells تبع ال hepatocyte بالتأكيد
+
+21
+00:01:40,710 --> 00:01:44,170
+لما يصير فيه display لل .. لل antigen تبع الفيروس
+
+22
+00:01:44,170 --> 00:01:47,290
+مش بتصير بعد هي كده ال cytocytic cell هتيجي تعمل
+
+23
+00:01:47,290 --> 00:01:52,750
+attack لهذه الخلايا و تعمل لها destructionالـ
+
+24
+00:01:52,750 --> 00:01:56,410
+Pathogenesis تبع الـ Hepatitis B فيروس غالبا ناتج
+
+25
+00:01:56,410 --> 00:02:00,330
+عن الـ cell-mediated immunity أكتر من ناتج عن الـ
+
+26
+00:02:00,330 --> 00:02:03,110
+virus destruction، تعرفين ليش؟ لأن الفيروس بتكاثر
+
+27
+00:02:03,110 --> 00:02:05,050
+بالـ body، بمعنى أنه بياخد يزور من الـ cell
+
+28
+00:02:05,050 --> 00:02:09,710
+-membrane، وتبقى الخلية intact، متكاملة، وما بتموت
+
+29
+00:02:09,710 --> 00:02:14,110
+من الـ viral replicationولكن لابد أن ننوح أيضًا
+
+30
+00:02:14,110 --> 00:02:17,870
+إلى أهمية الـ Antigen Antibody Complexes اللي ممكن
+
+31
+00:02:17,870 --> 00:02:23,110
+تتكون فيه و تسبب بعض ال early symptoms في المرضى
+
+32
+00:02:23,110 --> 00:02:29,260
+مثل الارثرالجيا و الارتكارية أو الحساسيةوبعض
+
+33
+00:02:29,260 --> 00:02:31,420
+التعريفات الخاصة بـ Chronic Hepatitis زي الـ
+
+34
+00:02:31,420 --> 00:02:34,760
+Immune Complex, Glomerul, Nephritis وVasculitis.
+
+35
+00:02:34,820 --> 00:02:38,180
+إذن الـ Immune Complexes بالإضافة إلى Cell Media
+
+36
+00:02:38,180 --> 00:02:42,360
+Immunity هم الـ Major Factors أو Players في عملية
+
+37
+00:02:42,360 --> 00:02:48,580
+Pathogenesis للـ Hepatitis B. كما ذكرت قبل قليل، 5
+
+38
+00:02:48,580 --> 00:02:52,500
+% من المرضى اللي عندهم Hepatitis B Virus يتحولوا
+
+39
+00:02:52,500 --> 00:02:56,460
+إلى Chronic Carriers. لـ Chronic Carrier تعريفه هو
+
+40
+00:02:56,460 --> 00:03:01,430
+شخصتم الكشف عن الـ hepatitis surface antigen في
+
+41
+00:03:01,430 --> 00:03:05,090
+دمه في فترة على الأقل ستة أشهر بمعنى أنه استمر الـ
+
+42
+00:03:05,090 --> 00:03:10,750
+antigen positive في دمه إلى فترة ستة أشهر الآن هذا
+
+43
+00:03:10,750 --> 00:03:13,290
+تعريف لمين؟ للـ chronic carrier معناه الحكي أن
+
+44
+00:03:13,290 --> 00:03:18,550
+الإنسان ممكن ينصاب و يشفى خلال فترة مين؟ الستة
+
+45
+00:03:18,550 --> 00:03:22,210
+أشهر أما هؤلاء الذين لا يشفون اتحوروا إلى مين
+
+46
+00:03:22,210 --> 00:03:27,680
+قلنا؟ إلى الـ chronic carrierطبعا الـ chronic
+
+47
+00:03:27,680 --> 00:03:31,620
+carrier state ممكن يعني نعزوها إلى ما يسمى بالـ
+
+48
+00:03:31,620 --> 00:03:34,360
+persistent infection والـ persistent infection في
+
+49
+00:03:34,360 --> 00:03:37,460
+اللي يبعته ال sites غالبا تنتج من الـ prolonged
+
+50
+00:03:37,460 --> 00:03:42,340
+presence of HPV DNA في وين الدي .. يعني كنا
+
+51
+00:03:42,340 --> 00:03:45,040
+بيصيرله integration فاكرين؟ كنا جزء منه بيصيرله
+
+52
+00:03:45,040 --> 00:03:49,320
+integration في الجنوم تبعنا و جزء منه بيبقى بشكل
+
+53
+00:03:49,320 --> 00:03:55,060
+ابيزوم ابيزوم يعني حر بعيد عن الكرومظومفيه إمكانية
+
+54
+00:03:55,060 --> 00:03:59,040
+لبعض الـ copies من ال DNA تبع الهيباطيتس أن يصبح
+
+55
+00:03:59,040 --> 00:04:01,740
+له integration وهذا اللي يؤدي إلى chronic
+
+56
+00:04:01,740 --> 00:04:08,080
+infection state ان يطيب الإنسان او يتحول ل chronic
+
+57
+00:04:08,080 --> 00:04:14,940
+carrier state هذا قرار مين اللي بيحدده كفاية كفاية
+
+58
+00:04:14,940 --> 00:04:18,000
+ال immune system المتمثل بمين بال cell mediated
+
+59
+00:04:18,000 --> 00:04:22,180
+immunityخد بالكوا في ال initial infection ال cell
+
+60
+00:04:22,180 --> 00:04:28,300
+-mediated immunity هي الأساس لكن عشان نعمل
+
+61
+00:04:28,300 --> 00:04:32,880
+elimination للفيروس ال humoral antibody هو الأساس
+
+62
+00:04:32,880 --> 00:04:36,820
+واللي بوفرنا lifelong protection من الإصابة مرة
+
+63
+00:04:36,820 --> 00:04:40,020
+أخرى بالفيروس هو ال humoral immunity وليس ال cell
+
+64
+00:04:40,020 --> 00:04:44,440
+-mediated immunity واذكروا هذه المعلومة جيدا لما
+
+65
+00:04:44,440 --> 00:04:48,790
+يكون الفيروس بيمرض بمرحلة viremiaالـ
+
+66
+00:04:48,790 --> 00:04:53,310
+Immunoglobulin مهم جدا لأنه يعمل نتراليزيش
+
+67
+00:04:53,310 --> 00:04:55,590
+للإنفكتفية تبع هذا الفيروس
+
+68
+00:05:01,500 --> 00:05:04,100
+الـ chronic carrier state بينتج عنها high rate of
+
+69
+00:05:04,100 --> 00:05:10,200
+هباطوسيلرار كارسينونا، طب يا جماعة دراسنا اللي هو
+
+70
+00:05:10,200 --> 00:05:13,640
+ال genome تبع الهيبوتايتس بي مايلاجناش Oncogenes،
+
+71
+00:05:13,640 --> 00:05:17,840
+مافي Oncogenes، إذا كيف نفسر حدوث سوطان في ال
+
+72
+00:05:17,840 --> 00:05:22,660
+liver ناتج عن الإصابة بالهيبوتايتس بي، قعدنا تلت
+
+73
+00:05:22,660 --> 00:05:26,910
+تفسيراتالتفسير الأول احنا ذكرنا قبل قليل انه
+
+74
+00:05:26,910 --> 00:05:30,530
+الفيروس اللي بتكاثر بيطلع ال antigen تبعه على ال
+
+75
+00:05:30,530 --> 00:05:33,090
+hepatocyte and it will be attacked by mean
+
+76
+00:05:33,090 --> 00:05:36,630
+cytotoxic T cell هذا ال attack و ال killing
+
+77
+00:05:36,630 --> 00:05:41,210
+بيستلزم من ال liver ان يعمل regeneration اش يعني
+
+78
+00:05:41,210 --> 00:05:46,430
+regeneration يعادة انتاج خلالها بدل الخلايا اللي
+
+79
+00:05:46,430 --> 00:05:53,580
+ماتتإعادة الإنتاج بتكون عملية سريعة ومتسرعة ومافيش
+
+80
+00:05:53,580 --> 00:05:58,000
+فيها الحكمة تبع من؟ تبع ال natural die off ايش ال
+
+81
+00:05:58,000 --> 00:06:01,320
+natural die off؟ اللي هو الموت الطبيعي للخلال
+
+82
+00:06:01,320 --> 00:06:06,140
+والإحلال تمام؟ بتكون عملية سريعة ومتسرعة ونسبة
+
+83
+00:06:06,140 --> 00:06:11,640
+الخطأ بتكون فيها عالية فمن ال regeneration النتج
+
+84
+00:06:11,640 --> 00:06:15,040
+ممكن يسيبنا cancer يعني ال regeneration نفسه يعمل
+
+85
+00:06:15,040 --> 00:06:21,920
+cancer هذا واحد اتنيناتنين في عندي نقطة مهمة جدا
+
+86
+00:06:21,920 --> 00:06:27,100
+متعلقة بال insertion احنا مش قولنا قبل شويه انه ال
+
+87
+00:06:27,100 --> 00:06:29,980
+genome بيصيله insertion في ال genome تبع الإنسان
+
+88
+00:06:29,980 --> 00:06:33,340
+طب هذا بيعمل mutation ولا بيعملش mutation؟ ممكن
+
+89
+00:06:33,340 --> 00:06:37,440
+يعمل insertion ال mutation و أي mutation قد تؤدي
+
+90
+00:06:37,440 --> 00:06:42,540
+إلى سرطان، مظبوط؟ الخيار التالت أو النظرية الثالثة
+
+91
+00:06:42,540 --> 00:06:47,760
+بتقول انه ال insertion تبعه غالبا بيكون بالقرب من
+
+92
+00:06:48,460 --> 00:06:53,300
+Human Oncogen يعني احنا هالنا Oncogen خاصة فينا،
+
+93
+00:06:53,300 --> 00:07:00,790
+مظبوط؟ Controlled، معمولها suppressionمن قبل الجين
+
+94
+00:07:00,790 --> 00:07:04,710
+تاني لأنه هذا الجين اللي عمل suppression للأنكوجين
+
+95
+00:07:04,710 --> 00:07:09,530
+صار في insertion لل DNA تبع الهيباطيتس وصار في
+
+96
+00:07:09,530 --> 00:07:14,510
+mutation يبقى ال protein بطل يطلع يبقى بطل يعمل
+
+97
+00:07:14,510 --> 00:07:17,450
+suppression لمن؟ للأنكوجين فالأنكوجين صار له
+
+98
+00:07:17,450 --> 00:07:21,650
+expression صار عندنا سلطان إذا كم خيار كم مرة؟
+
+99
+00:07:21,650 --> 00:07:25,950
+تلاتة replacement of cells أو regeneration تؤدي
+
+100
+00:07:25,950 --> 00:07:30,290
+إلى cancerinsertional mutation أو insertion near
+
+101
+00:07:30,290 --> 00:07:37,210
+gona cellular oncogene الآن
+
+102
+00:07:37,210 --> 00:07:41,610
+بنتكلم عن الأمر و علاقته بال chronic infection
+
+103
+00:07:41,610 --> 00:07:44,930
+طلعولي على الرقم اللي موجود على اللوحة في الوسط في
+
+104
+00:07:44,930 --> 00:07:49,350
+ال approximately 90% of infected neonates become
+
+105
+00:07:49,350 --> 00:07:54,920
+chronic carriers حواليتسعين بالمائة من المواليد
+
+106
+00:07:54,920 --> 00:07:58,840
+المصابين يعني ايش مصابين؟ اخدوها من وين؟ من الام
+
+107
+00:07:58,840 --> 00:08:02,660
+في الغالب تمام؟ بتحولوا الى career state إذا نسبة
+
+108
+00:08:02,660 --> 00:08:07,440
+ال career state عالية جدا في مين؟ في ال neonates
+
+109
+00:08:07,440 --> 00:08:11,360
+كل ما كبل الإنسان أكتر و أصيبه على سن أكبر
+
+110
+00:08:11,360 --> 00:08:15,260
+احتمالية انه يتحول ل chronic career بتكون مالها
+
+111
+00:08:15,260 --> 00:08:23,420
+أقل إذا أضخم نسبة هم بالفعل ال neonatesكمان مساكين
+
+112
+00:08:23,420 --> 00:08:27,400
+لإن هما أضخم نسبة بتحول ل Corona Carrier برضه
+
+113
+00:08:27,400 --> 00:08:33,840
+هيكون هما أضخم نسبة او ضلمين لل Hepatocarcinoma أو
+
+114
+00:08:33,840 --> 00:08:36,880
+الـ Hepatoma اللي حاكينا عنها، إذا ال neonate فئة
+
+115
+00:08:36,880 --> 00:08:43,640
+fragile لهذا المرضLifelong immunity غالبا نتج عن
+
+116
+00:08:43,640 --> 00:08:47,200
+مين قلنا؟ عن الانتيبادات ضد مين؟ ضد ال surface
+
+117
+00:08:47,200 --> 00:08:51,540
+antigen احنا في المحاضرة الماضية اتكلمنا عن three
+
+118
+00:08:51,540 --> 00:08:55,400
+antigens surface antigen و car antigen و E
+
+119
+00:08:55,400 --> 00:08:58,820
+-antigen، مظبوط؟ قلنا ال surface antigen خارجي
+
+120
+00:08:58,820 --> 00:09:03,130
+بينما ال car و E موجودينفي الـNucleocapsid جوا
+
+121
+00:09:03,130 --> 00:09:07,590
+وبالتالي يا بنات الـAntibody اللى بتكون للـC والـE
+
+122
+00:09:07,590 --> 00:09:11,430
+مابيدخلش الى داخل الفيروس يتفاعل معاه يبقى mainly
+
+123
+00:09:11,430 --> 00:09:15,530
+protective فقط اللى هو الـAntibody ضد ال surface
+
+124
+00:09:15,530 --> 00:09:19,210
+antigen وكده لكوا احفظه Hepatitis surface antigen
+
+125
+00:09:19,210 --> 00:09:24,510
+HPSAG هذا يعني Antigen مهم جدا اللى ممكن انه ننساه
+
+126
+00:09:24,510 --> 00:09:29,270
+والـAntibody تبعه كذلك الأمر لإن هوالمؤشر على
+
+127
+00:09:29,270 --> 00:09:34,370
+الشفاء أو عدم الشفاء في موضوع الـ Hepatitis B يعني
+
+128
+00:09:34,370 --> 00:09:38,650
+وجود antibodies للـC أو للـE بيهموناش كتير في
+
+129
+00:09:38,650 --> 00:09:42,890
+الموضوع اللي هو الـprognosis بقى ال disease فقط
+
+130
+00:09:42,890 --> 00:09:45,650
+الـAnti-HPSAG
+
+131
+00:09:47,670 --> 00:09:52,170
+يبقى معناه حاكيه هالأ ال ال antibody لل surface لل
+
+132
+00:09:52,170 --> 00:09:56,590
+C انتجين is not mellow not protective و لنفس السبب
+
+133
+00:09:56,590 --> 00:10:03,250
+اللي ذكرناه أنه هو جوا الفيروس مش برا الفيروسالان
+
+134
+00:10:03,250 --> 00:10:06,470
+بالنسبة للأعراض بتاعة الـ Hepatitis B احنا ذكرنا
+
+135
+00:10:06,470 --> 00:10:11,250
+في مقدمة الـ Hepatitis بشكل عام ان كل الـ
+
+136
+00:10:11,250 --> 00:10:15,210
+Hepatitis viruses have similar symptoms من ضمن الـ
+
+137
+00:10:15,210 --> 00:10:19,010
+symptoms هذه اللي هو انها fever و jaundice و dark
+
+138
+00:10:19,010 --> 00:10:22,570
+urine و pale stool بالاضافة الى elevated
+
+139
+00:10:22,570 --> 00:10:26,890
+transaminase اللي هو الـ ALT و EST او الـSGBT
+
+140
+00:10:26,890 --> 00:10:30,570
+وSGOT اللي هو liver function test
+
+141
+00:10:32,020 --> 00:10:34,720
+اقرؤ الجملة الأخيرة ايش بتقول الجملة الأخيرة في
+
+142
+00:10:34,720 --> 00:10:40,560
+اللوحة بتقول انه hepatitis B symptoms tend to be
+
+143
+00:10:40,560 --> 00:10:45,600
+more severe يعني بتتشابه مع الباقي لكن الاعاطراتها
+
+144
+00:10:45,600 --> 00:10:50,480
+بتكون ايه اكتر حده من ال other hepatitis غالبا
+
+145
+00:10:50,480 --> 00:10:55,200
+فينا كمان life threatening hepatitis في كمان
+
+146
+00:10:55,200 --> 00:10:57,560
+اختلاف مهم جدا في ال hepatitis B اللي هو ال
+
+147
+00:10:57,560 --> 00:11:01,000
+incubation periodالـ Incubation period بتبعات الـ
+
+148
+00:11:01,000 --> 00:11:04,260
+Hepatitis A جُن عنها تلات الاربع أسابيع، يعني
+
+149
+00:11:04,260 --> 00:11:08,560
+maximum شهر، بينما هنا نتكلم عن عشر إلى أطن عشر
+
+150
+00:11:08,560 --> 00:11:12,960
+أسبوع طبعا أنا قدمت في المحاضرة السابقة إن الـ
+
+151
+00:11:12,960 --> 00:11:16,520
+Hepatitis A Incubation Period is short وقلتلكوا
+
+152
+00:11:16,520 --> 00:11:20,460
+short بالمقارنة بالـ other Hepatitis viruses، لكن
+
+153
+00:11:20,460 --> 00:11:23,680
+أنا بتكلم عن الـ common cold أو الـ influenza،
+
+154
+00:11:23,680 --> 00:11:25,840
+يعني very short اللي .. اللي .. اللي .. اللي هو
+
+155
+00:11:25,840 --> 00:11:28,280
+الـ Incubation period طيب
+
+156
+00:11:30,520 --> 00:11:33,120
+أعتقد المصطلح هذه بنات الزجنة اللي احنا بتتكلم فيه
+
+157
+00:11:33,120 --> 00:11:35,760
+اللي هو الـimmune reconstitution وبنالكوا في حال
+
+158
+00:11:35,760 --> 00:11:41,720
+موجود HIV و HPV لابد انه نهالج الـHPV جانب ما
+
+159
+00:11:41,720 --> 00:11:44,940
+نهالج الـHIV عشان مايصيرش عندنا immune
+
+160
+00:11:44,940 --> 00:11:48,220
+reconstitution يصحى جهاز المناع ويقول انت ايش
+
+161
+00:11:48,220 --> 00:11:51,200
+بتسوي هنا ويبقى دي اعمل destruction لين؟ لل liver
+
+162
+00:11:51,200 --> 00:11:55,560
+cells تمثيل
+
+163
+00:11:57,280 --> 00:12:00,600
+مهم للانتيجينات الثلاثة اللي ذكرناها ال surface
+
+164
+00:12:00,600 --> 00:12:04,220
+antigen كان المرور موجود على السطح بينما ال C و ال
+
+165
+00:12:04,220 --> 00:12:07,540
+E موجودين في ال core وبالتالي بالفعل ال antibody
+
+166
+00:12:07,540 --> 00:12:10,360
+لما بيجي بيشتغل بيشتغل على مين على ال surface مش
+
+167
+00:12:10,360 --> 00:12:14,980
+على ال core هذا ال diagram كتير حلو لازم نطلع عليه
+
+168
+00:12:14,980 --> 00:12:20,080
+بشكل جيد تابوا معايا بدون كتابة الآن وانطبعوا على
+
+169
+00:12:20,080 --> 00:12:25,460
+الصبورة ونتطلع على اللي هو الخط الزهري هذااللي
+
+170
+00:12:25,460 --> 00:12:29,580
+بيمثل مين؟ Hepatitis Surface Antigen Normally إذا
+
+171
+00:12:29,580 --> 00:12:35,520
+كان في عملية شفاء للمريض بيصل ل peak معين و بعدين
+
+172
+00:12:35,520 --> 00:12:40,460
+بينزل في ال peak هذا اطلعولي على إيش ال symptoms
+
+173
+00:12:40,460 --> 00:12:44,640
+بتكون موجودة في فترة ال peak صح؟ و ال elevated
+
+174
+00:12:44,640 --> 00:12:48,100
+transaminase اللي هم ال liver function enzymes
+
+175
+00:12:48,100 --> 00:12:52,970
+برضه بيكونوا مرتفعين في فترة ارتفاعاللي هو الـ
+
+176
+00:12:52,970 --> 00:12:57,510
+hepatitis surface antigen اطلعولي على ال hepatitis
+
+177
+00:12:57,510 --> 00:13:04,770
+E antigen فترة طواري أشمالها أكثر صح؟ طب مش
+
+178
+00:13:04,770 --> 00:13:11,350
+المفروض يكون في علاقة بينهم؟ مش ال E هو جزء من
+
+179
+00:13:11,350 --> 00:13:16,350
+الفيروس ليش ما أعطاش نفس اللي هو ال level تبع ال
+
+180
+00:13:16,350 --> 00:13:17,110
+surface antigen
+
+181
+00:13:20,530 --> 00:13:24,870
+لأ اتذكروا اتذكروا ان هذا الفيروس إيه له طبيعة
+
+182
+00:13:24,870 --> 00:13:29,330
+اختلفت عن باقي الفيروسات كلها أنتج surface antigen
+
+183
+00:13:29,330 --> 00:13:33,110
+بشكل كوريات صغيرة و بشكل filaments يبقى ال surface
+
+184
+00:13:33,110 --> 00:13:37,310
+antigen هيكون حجمه ألاف الأضعاف بالمقارنة مع مين
+
+185
+00:13:37,310 --> 00:13:42,130
+مع ال DNA بتاع ال virus نفسه و مع اللي هو ال other
+
+186
+00:13:42,130 --> 00:13:46,670
+antigens لإن ال real virus بيحتوي على surface و
+
+187
+00:13:46,670 --> 00:13:51,860
+coreو E-antigen بينما ال filaments و ال spheres
+
+188
+00:13:51,860 --> 00:13:55,020
+اللي حكينا عنهم هم اللي بيحترقوا فقط على surface
+
+189
+00:13:55,020 --> 00:14:00,640
+antigen و قلنا لكوا انه واحد الى الف يعني واحد
+
+190
+00:14:00,640 --> 00:14:04,040
+فيروس الى الف قطعة أخرى فبالتالي بالفعل ال surface
+
+191
+00:14:04,040 --> 00:14:08,800
+antigen ايش ماله؟ وهل وجود surface antigen يعني
+
+192
+00:14:08,800 --> 00:14:15,420
+وجود الفيروس؟ ايش رأيكم؟لكن وجود E-antigen معناته
+
+193
+00:14:15,420 --> 00:14:19,180
+اللي حكي الفيروس معله موجود إذن اتطلعوا على النقطة
+
+194
+00:14:19,180 --> 00:14:23,020
+هذه هذا Indicator رائع جدا لمن؟ لـ
+
+195
+00:14:23,020 --> 00:14:27,100
+Transmissibility إيش ال Transmissibility؟ يعني إن
+
+196
+00:14:27,100 --> 00:14:31,680
+الفيروس موجود ويمكن أن ينتقل من إنسان إلى إنسان
+
+197
+00:14:31,680 --> 00:14:37,000
+وصلت الصورة وجود ال E في هذا الحالة Indicator جيد
+
+198
+00:14:37,000 --> 00:14:41,820
+سبونا من المناعة أنا الآن بتكلم على دلالاتاللي هو
+
+199
+00:14:41,820 --> 00:14:44,280
+الـ Hepatitis الـ Markers اللي هم اللي بيسموه
+
+200
+00:14:44,280 --> 00:14:48,060
+Markers ما الذي يعني كل واحد من هذه ال Markers
+
+201
+00:14:48,060 --> 00:14:50,660
+كمان مرة في عندي surface antigen و في عندي هنا إيش
+
+202
+00:14:50,660 --> 00:14:55,880
+مقلد تاني هذا اسمه E-antigen شوفوا الـ Anti-HPS ال
+
+203
+00:14:55,880 --> 00:15:02,660
+Anti-HPC طلع في فترة كان فيه Peak عندي هناوهذا
+
+204
+00:15:02,660 --> 00:15:09,340
+موجود طول الفترة، لكن هل له قيمة؟ هل له قيمة في
+
+205
+00:15:09,340 --> 00:15:14,220
+المناعة تبع الإنسان؟ ليش مالوش قيمة؟ لأنه ماتفعلش
+
+206
+00:15:14,220 --> 00:15:17,820
+مع الفيروس من برا، لازم يدخل جوا، ودخول جوا مافيش
+
+207
+00:15:17,820 --> 00:15:21,700
+إمكان يدخله، فمالوش قيمة في المناعة تبع الإنسان،
+
+208
+00:15:21,700 --> 00:15:27,630
+في فترة بنات هنابسموها window period، لاحظوا مش
+
+209
+00:15:27,630 --> 00:15:31,370
+فيها surface antigen ولا فيها anti-HPS، اللي هو
+
+210
+00:15:31,370 --> 00:15:37,770
+الـantibody تبعه، لكن مش فيها anti-HPE وanti-HPC،
+
+211
+00:15:37,770 --> 00:15:41,070
+يعني هؤلاء التنين الموجودين في نفس الفترة هذه، إيش
+
+212
+00:15:41,070 --> 00:15:45,830
+يعني window period؟يعني مش جادرين نمسك ال antigen
+
+213
+00:15:45,830 --> 00:15:48,370
+و لا نمسك ال antibody تبعها لل antigen مين ال
+
+214
+00:15:48,370 --> 00:15:51,270
+antigen الأساسي أننا ال surface اللي هو ال surface
+
+215
+00:15:51,270 --> 00:15:55,850
+antigen نعم فهذه بيسموها window period إذا أكم
+
+216
+00:15:55,850 --> 00:16:00,250
+marker عندنا الآن تلت انتجينات و تلت antibody
+
+217
+00:16:00,250 --> 00:16:03,650
+تبعهم تلت antibody بيسموهم hepatitis marker تعالوا
+
+218
+00:16:03,650 --> 00:16:07,650
+نستغلهم و نشوف بعض منهم كيف ممكن يخدمنا في ال
+
+219
+00:16:07,650 --> 00:16:13,920
+diagnosisأكان فحص عندي هنا تلاتة surface antigen و
+
+220
+00:16:13,920 --> 00:16:20,980
+surface antibody و core antibody مجسم
+
+221
+00:16:20,980 --> 00:16:27,160
+انا اربع عاملة acute disease window phase complete
+
+222
+00:16:27,160 --> 00:16:32,700
+recovery و chronic carrier state اربع حالات
+
+223
+00:16:32,700 --> 00:16:35,780
+بنشوفهم في ال hepatitis ايش يعني complete
+
+224
+00:16:35,780 --> 00:16:42,150
+recovery؟يعني شوفيا تماما ايش بنشوف عنده؟ negative
+
+225
+00:16:42,150 --> 00:16:49,870
+surface antigen positive surface antibody positive
+
+226
+00:16:49,870 --> 00:16:56,270
+core antibody لحظولي لو واحد أخد vaccine لو واحد
+
+227
+00:16:56,270 --> 00:17:02,170
+أخد vaccine ايش بتختلف عن هذا؟
+
+228
+00:17:02,170 --> 00:17:05,490
+اللي أخد vaccine هكوّن أجسام مضادة لمن؟ لل surface
+
+229
+00:17:05,490 --> 00:17:10,250
+antigenبس مش هيكوّل لمن؟ لل car وبالتالي بيكون
+
+230
+00:17:10,250 --> 00:17:12,890
+negative positive negative هذا بيكون negative
+
+231
+00:17:12,890 --> 00:17:16,070
+positive positive لإنه لديه natural infection
+
+232
+00:17:16,070 --> 00:17:20,970
+natural infection يبقى ال complete recovery بتتميز
+
+233
+00:17:20,970 --> 00:17:26,960
+بشرة بنات بوجودsurface antibody فى غيره فى surface
+
+234
+00:17:26,960 --> 00:17:31,800
+antibody نيجاتيف نيجاتيف نيجاتيف هو الوحيد اللى
+
+235
+00:17:31,800 --> 00:17:37,000
+أعطاناه positive وهو المؤشر الحقيقي لعملية ال
+
+236
+00:17:37,000 --> 00:17:41,500
+recovery وجود antibody هو مؤشر لل recovery طب طبعا
+
+237
+00:17:41,500 --> 00:17:46,560
+طلع ال chronic career state حلج هذا positive وحلج
+
+238
+00:17:46,560 --> 00:17:51,590
+هذا positive لكن حلج هذا في مقلهيعني مدام لم يظهر
+
+239
+00:17:51,590 --> 00:17:55,850
+Anti-HPS بنات، اعتبروا ان المريض ماله دخل في حالة
+
+240
+00:17:55,850 --> 00:18:00,160
+Chronic اللي هو Stigmaالويندوزة اللي حاولت أخبركم
+
+241
+00:18:00,160 --> 00:18:03,600
+عنها نيجاتيف نيجاتيف ميه اللي بيكون عنها surface
+
+242
+00:18:03,600 --> 00:18:07,860
+antibody أو C أفضل C antibody بتكون بوستف ال acute
+
+243
+00:18:07,860 --> 00:18:12,180
+disease وكلمة acute يعني اللي بتظهر فيها الأعراض
+
+244
+00:18:12,180 --> 00:18:15,580
+الصفار اللي بيكون عنه و ال elevated transaminases
+
+245
+00:18:15,580 --> 00:18:19,920
+بتكون surface antigen بوستف نيجاتيف للعنتبادي و
+
+246
+00:18:19,920 --> 00:18:26,480
+بوستف للهيبوتايتس B core antibody طب طلعولي هنا
+
+247
+00:18:26,480 --> 00:18:30,760
+على ال acute disease وعلى مين؟على الـ chronic
+
+248
+00:18:30,760 --> 00:18:36,280
+disease، أيش فيه فرق بينهم؟ هي postive و postive،
+
+249
+00:18:36,280 --> 00:18:39,660
+negative و negative، و postive إيش؟ postive، إذا
+
+250
+00:18:39,660 --> 00:18:43,140
+الفرق إن هناك فيش symptoms صار و أنا فيه أنها
+
+251
+00:18:43,140 --> 00:18:44,320
+symptoms فقط
+
+252
+00:18:47,670 --> 00:18:52,330
+لتريتمنت الحقيقة انه بتعرف ان ال liver لما بيكون
+
+253
+00:18:52,330 --> 00:18:55,290
+صار فيه destruction برضه بيصير فيه inflammation
+
+254
+00:18:55,290 --> 00:18:59,470
+فممكن لو طبيب يعطيه عققير ماعناهش علاقة بال .. بال
+
+255
+00:18:59,470 --> 00:19:02,750
+.. بال virus نفسه وانما Anti-inflammatory .. Anti
+
+256
+00:19:02,750 --> 00:19:06,650
+-inflammatory لكن العققير الحقيقية اللي بتوعطه في
+
+257
+00:19:06,650 --> 00:19:08,810
+حالة ال .. ال hepatitis B
+
+258
+00:19:11,960 --> 00:19:15,220
+Hepatitis B infection هي الـ Alpha interferon
+
+259
+00:19:15,220 --> 00:19:19,340
+والمفيودين و ال adivivore هدولها تلت drugs
+
+260
+00:19:19,340 --> 00:19:22,940
+المشهورين في علاج ال .. ال .. ال hepatitis لكن
+
+261
+00:19:22,940 --> 00:19:27,680
+كلهم بيعملوا حاسب mitigation ايش انهي mitigation؟
+
+262
+00:19:27,680 --> 00:19:32,320
+بيخففوا من ال effect تبع الفيروس لكن ما بيقدروا
+
+263
+00:19:32,320 --> 00:19:36,340
+يشيلوا ال chronic carrier state ال vaccine مار
+
+264
+00:19:36,340 --> 00:19:39,520
+معانا ال vaccine المحاضرة السابقة لما اتكلمنا عن
+
+265
+00:19:39,520 --> 00:19:43,750
+ال Twinrixو هناك و ال twinrix عمل ال decrease لل
+
+266
+00:19:43,750 --> 00:19:47,630
+incidence of hepatocellular carcinoma in children
+
+267
+00:19:47,630 --> 00:19:51,930
+لمين ال vaccine مش بيحتوى او افوان بيحتوى على ال
+
+268
+00:19:51,930 --> 00:19:55,990
+hepatitis B surface antigen و انا قبل قليل قلتلكوا
+
+269
+00:19:55,990 --> 00:20:02,070
+كيف نميز من ال natural infection و ما بين
+
+270
+00:20:02,070 --> 00:20:05,990
+protection بال vaccine هو غياب ال antibody لل core
+
+271
+00:20:05,990 --> 00:20:12,920
+antigenلمن يعطيها للفاكسين؟ زمان كنا طالبات اتحاد
+
+272
+00:20:12,920 --> 00:20:14,880
+الطبي و طالب اتحاد الطبية كنا قبل ما نروح على
+
+273
+00:20:14,880 --> 00:20:17,680
+مستشفى ليش؟ لأ قبل ما نروح على مستشفى لأن هم من
+
+274
+00:20:17,680 --> 00:20:21,300
+الناس المعاضي لل blood and blood products كنا
+
+275
+00:20:21,300 --> 00:20:23,960
+نعملهم vaccination طبعا لإن انتوا أخدتوا الفاكسين
+
+276
+00:20:23,960 --> 00:20:27,980
+كاطفال فصرتوا انتوا لازم من ال cycle بعد هي كده
+
+277
+00:20:27,980 --> 00:20:32,720
+يعني كل الأطفال اللي وراكم مثلا موديل كام انتوا؟
+
+278
+00:20:32,720 --> 00:20:36,000
+اللي هو ممكن بدأ من .. من أوائل التسعينات يمكن ال
+
+279
+00:20:36,000 --> 00:20:42,190
+.. ال .. الفاكسينتبتدى أجيال كثيرة وراكم برضه أخدت
+
+280
+00:20:42,190 --> 00:20:46,170
+هذا ال vaccine كمان patient receiving multiple
+
+281
+00:20:46,170 --> 00:20:49,090
+transfusion or dialysis بتعرفوا انتوا في مرضى
+
+282
+00:20:49,090 --> 00:20:53,130
+عندهم مشاكل في الدن او مشاكل في الكيلية بيتعرضوا
+
+283
+00:20:53,130 --> 00:20:57,590
+لغسيل الكيلية هدول الناس باستمرار بحتكوا بمكن
+
+284
+00:20:57,590 --> 00:21:01,510
+المكن هذا مش مخصص لإنسان واحد المكينة الواحدة بيقل
+
+285
+00:21:01,510 --> 00:21:06,840
+عليها اكتر من شخصو في الأسبوع ممكن يغسله مرتين او
+
+286
+00:21:06,840 --> 00:21:12,020
+تلاتة لنفس الشخص و معروف عالميا ان ال dialysis
+
+287
+00:21:12,020 --> 00:21:16,800
+machine هي ناقل من نواقل ال hepatitis B and C و
+
+288
+00:21:16,800 --> 00:21:18,780
+احنا عملنا دراسة في قطاع غزة على ال hemodialysis
+
+289
+00:21:18,780 --> 00:21:22,300
+patient اخدنا كل المرضى اللي كانوا hemodialysis
+
+290
+00:21:22,300 --> 00:21:25,940
+patient في ذاك الوقت و بالفعل وضبنا انه نسبة كبيرة
+
+291
+00:21:25,940 --> 00:21:28,160
+من اللي عندهم hepatitis C اعلى من النسبة اللي
+
+292
+00:21:28,160 --> 00:21:32,510
+موجودة في المجتمعمؤشر عليه على إنه في البعض منه
+
+293
+00:21:32,510 --> 00:21:35,950
+منتقله الـ Hepatitis C من وين من الـ Hemodialysis
+
+294
+00:21:35,950 --> 00:21:40,450
+patient فبتالي لو أنا واحد أجانب جديد بده يغسل
+
+295
+00:21:40,450 --> 00:21:45,490
+يعني صار عنده kidney failure و بده يغسل الأصل
+
+296
+00:21:45,490 --> 00:21:48,930
+نفحصه إذا عنده ماعندهوش antibody ل ال hepatitis
+
+297
+00:21:48,930 --> 00:21:54,610
+surface antigen نعطيه vaccine عشان نحميه من
+
+298
+00:21:54,610 --> 00:21:58,070
+الإصابة بال hepatitis خلال العملية اللي هو الغسيلة
+
+299
+00:21:59,400 --> 00:22:01,900
+طبعا الفئة التالتة اللي هم الـ all newborns كود
+
+300
+00:22:01,900 --> 00:22:06,540
+المولد الجدد وانها ده الكلام كسياسة تم اتباعها
+
+301
+00:22:06,540 --> 00:22:13,380
+ممكن هو يُعطى على شكل تلت جرعات ال booster dose
+
+302
+00:22:13,380 --> 00:22:18,260
+غالبا مابنحتاجهاش إلا للأشخاص التنشيطية لكن في
+
+303
+00:22:18,260 --> 00:22:23,160
+غالب الآخرين اللي هم مش at risk groups في غالب
+
+304
+00:22:23,160 --> 00:22:26,040
+الأمر مابنعطيهمش booster dose
+
+305
+00:22:29,210 --> 00:22:31,190
+بالنسبة للـ Immunoglobulin او Hepatitis B
+
+306
+00:22:31,190 --> 00:22:34,990
+immunoglobulin كلكم بتذكروا في ال vaccination او
+
+307
+00:22:34,990 --> 00:22:38,730
+ال viral vaccine لما اتكلمنا عن two examples of
+
+308
+00:22:38,730 --> 00:22:43,110
+post exposure vaccination وفي نفس الوجه تجدون
+
+309
+00:22:43,110 --> 00:22:46,650
+active and passive immunization هذا مثال جيد على
+
+310
+00:22:46,650 --> 00:22:51,350
+هذا الموضوع وبيحتوي على high titer من ال hepatitis
+
+311
+00:22:51,350 --> 00:22:55,210
+surface antigen immunoglobulin وهذا ال
+
+312
+00:22:55,210 --> 00:22:59,130
+immunoglobulin غالبا بيكون جايبينه من اناسأصيبوا
+
+313
+00:22:59,130 --> 00:23:02,150
+بـ hepatitis B و يشوفوا يوم منها أو هم vaccinated
+
+314
+00:23:02,150 --> 00:23:06,210
+و بناخد منهم يعني الـ immunoglobulin والحقيقة أنه
+
+315
+00:23:06,210 --> 00:23:13,030
+بيوفر immediate protection يعني حماية فورية للناس
+
+316
+00:23:13,030 --> 00:23:18,270
+خاصة إذا قلنا كده مرة تعرضوا و هم ما عندهمش مناعة
+
+317
+00:23:18,270 --> 00:23:24,110
+ضد هذا المرضالـ Hepatitis C Virus طبعا احنا
+
+318
+00:23:24,110 --> 00:23:26,610
+قلنالكوا الـ Hepatitis B كان شكل خطر كبير، الآن
+
+319
+00:23:26,610 --> 00:23:32,530
+الـ B مع وجود الفاكسين أصبح ثانوى بالنسبة لمن؟ لـ
+
+320
+00:23:32,530 --> 00:23:36,830
+Hepatitis C Virus ويوم كدا ذكرتلكوا انه في
+
+321
+00:23:36,830 --> 00:23:39,950
+المحاضرة السابقة ان جمهورية مصر العربية نسبة كبيرة
+
+322
+00:23:39,950 --> 00:23:45,470
+من الناس فيها مصابة بهذا ال virus وبيكلف الدولة
+
+323
+00:23:45,470 --> 00:23:52,790
+مبالغ ضخمة جدا لعلاج هؤلاء المرضىFLAVY معناها أصفر
+
+324
+00:23:52,790 --> 00:23:58,270
+بأساس صفراء انفلوب بوستف single-stranded RNA
+
+325
+00:23:58,270 --> 00:24:01,530
+نوفريون بوليماريزي لأن طبعا أكيد بوستف stranded
+
+326
+00:24:01,530 --> 00:24:06,470
+six genotypes and multiple subgenotypes بجهة هذا
+
+327
+00:24:06,470 --> 00:24:10,350
+كمان هيعملنا مشكلة تمينفي الvaccination هذا يعني
+
+328
+00:24:10,350 --> 00:24:14,570
+يقولنا for the sake of vaccine اعتبروه one single
+
+329
+00:24:14,570 --> 00:24:18,390
+serotype و for the sake of epidemiology اعتبروه
+
+330
+00:24:18,390 --> 00:24:23,190
+اربع genotypes او subtypes لكن هنا already six
+
+331
+00:24:23,190 --> 00:24:27,570
+genotypes and multiple subgenotypes وبتالي عاملنا
+
+332
+00:24:27,570 --> 00:24:32,510
+مشكلة بالفعل في عملية ال vaccineالـ blood هو الـ
+
+333
+00:24:32,510 --> 00:24:37,250
+main mood of transmission لهذا الفيروس ال needle
+
+334
+00:24:37,250 --> 00:24:42,350
+stick الغزة تبع الإبرة في الهيبوتايتس C أقل
+
+335
+00:24:42,350 --> 00:24:48,870
+احتمالا من مين من الهيبوتايتس B إذا هو blood و
+
+336
+00:24:48,870 --> 00:24:53,570
+blood بكميات غالبا لازم تكون كافية طبعا عندما بقول
+
+337
+00:24:53,570 --> 00:24:57,570
+needle stick هنا في الهيبوتايتس C أقل من
+
+338
+00:24:57,570 --> 00:25:01,090
+الهيبوتايتس B عارفين المؤشر على إيش؟مؤشر على أن
+
+339
+00:25:01,090 --> 00:25:08,070
+الـviremia level في الـB أعلى من الـC، هذا ممكن
+
+340
+00:25:08,070 --> 00:25:12,110
+يكون مؤشر، لكن ليس ضروري أن يكون صح، بس هي تفسير
+
+341
+00:25:13,470 --> 00:25:17,670
+Sexual transmission from mother to child is
+
+342
+00:25:17,670 --> 00:25:19,990
+inefficient يعني مش زي الهيباطيتس بيه، هنقول إن
+
+343
+00:25:19,990 --> 00:25:24,130
+الهيباطيتس بيه بثلاث طرق، دم، sexual intercourse و
+
+344
+00:25:24,130 --> 00:25:27,810
+from mother to fetus لكن هنا بقولنا إنه mainly
+
+345
+00:25:27,810 --> 00:25:33,290
+blood نادرًا من أم لطفل و نادرًا عبر اللي هو ال
+
+346
+00:25:33,290 --> 00:25:37,210
+sexual transmission يعني الانتقال أقل فعالية من
+
+347
+00:25:37,210 --> 00:25:41,460
+الهيباطيتس بيه بهذه الطرقit is the most prevalent
+
+348
+00:25:41,460 --> 00:25:44,280
+blood-borne pathogen طبعا هذه الكلام ماكانش صحيح
+
+349
+00:25:44,280 --> 00:25:48,800
+قبل إدخال مين؟ قبل إدخال ال hepatitis B vaccine
+
+350
+00:25:48,800 --> 00:25:52,200
+كان ال hepatitis B أعلى منه، لكن الان هو كون ال
+
+351
+00:25:52,200 --> 00:25:55,040
+hepatitis B بينخفض و هو الان بيرتفع
+
+352
+00:25:56,970 --> 00:26:00,910
+There is no evidence for an insect vector for HCV
+
+353
+00:26:00,910 --> 00:26:04,750
+طبعا insect vector يعني ان يكون من مين؟ من
+
+354
+00:26:04,750 --> 00:26:08,850
+الاربوفيروسز ..اربوفيروسز زي مين؟ زي ال yellow
+
+355
+00:26:08,850 --> 00:26:12,370
+fever حمّة الصفراء لإن هو من نفس العيلة yellow
+
+356
+00:26:12,370 --> 00:26:16,690
+fever نفس عيلة مين؟ اللي هو ال .. ال .. ال .. ال
+
+357
+00:26:16,690 --> 00:26:17,110
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+358
+00:26:17,110 --> 00:26:17,330
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+359
+00:26:17,330 --> 00:26:17,670
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+360
+00:26:17,670 --> 00:26:19,030
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+361
+00:26:19,030 --> 00:26:20,310
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+362
+00:26:20,310 --> 00:26:20,310
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+363
+00:26:20,310 --> 00:26:20,310
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+364
+00:26:20,310 --> 00:26:22,230
+ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+365
+00:26:25,810 --> 00:26:28,830
+كلمة no evidence يعني لحد دلوقتي مافيش لنا دليل
+
+366
+00:26:28,830 --> 00:26:32,150
+انه بينتقل عن طريق ال vector لكن قد يكون قد يكون
+
+367
+00:26:32,150 --> 00:26:36,070
+يعني الصراحة أنا مش قادر افسر لا استطيع تفسير
+
+368
+00:26:36,070 --> 00:26:40,830
+لماذا يوجد هذا العدد الكبير من مرض ال hepatitis C
+
+369
+00:26:40,830 --> 00:26:44,470
+في الجمهورية مصر العربي لا استطيع التفسير ان كلهم
+
+370
+00:26:44,470 --> 00:26:51,010
+أخذوا دم هذا يعني رقم ضخم جدا في ناس عمرهم ما
+
+371
+00:26:51,010 --> 00:26:56,190
+يأخذوا دمفطريقة الانتقال يعني ما زال ممكن يكون
+
+372
+00:26:56,190 --> 00:26:59,850
+عليها بعض اللي هو علامات الاستفهام وهذا أمر طبيعي
+
+373
+00:26:59,850 --> 00:27:05,010
+خاصة في الفيروسات الجديدة بنقعد سنين لما نكتشف طرق
+
+374
+00:27:05,010 --> 00:27:09,310
+الانتقال بشكل كاملImmunoglobulin preparations are
+
+375
+00:27:09,310 --> 00:27:14,090
+safe but transmission of HCV have occurred كلمة IG
+
+376
+00:27:14,090 --> 00:27:17,050
+immunoglobulin preparation احنا جالب الشباب بنقول
+
+377
+00:27:17,050 --> 00:27:21,690
+انه Hepatitis B immunoglobulin استخدمناها كعيلة
+
+378
+00:27:21,690 --> 00:27:27,670
+لمن؟ لل Hepatitis B من أين أخدناها؟من مرضى، صح؟
+
+379
+00:27:27,670 --> 00:27:31,710
+أخدنا هدول المرضى، إذا كان واحد من هؤلاء المرضى
+
+380
+00:27:31,710 --> 00:27:36,210
+عنده ال virus، وهذا كلمة بيقول أخدناه من مرضى، مش
+
+381
+00:27:36,210 --> 00:27:39,310
+من مريض واحد، بنعمل حاجة اسمها pooling، بناخد منهم
+
+382
+00:27:39,310 --> 00:27:42,610
+فلان وفلان وفلان وفلان، وبنجمعهم مع بعض، وبنفصل
+
+383
+00:27:42,610 --> 00:27:47,970
+منهم شوية سيرن محتوي على antibodyلو كان فيه مثلا
+
+384
+00:27:47,970 --> 00:27:51,670
+undetectable levels او ال testing efficiency مش
+
+385
+00:27:51,670 --> 00:27:54,650
+عالي مثلا في المؤسسة اللي بتحضر هذا ال
+
+386
+00:27:54,650 --> 00:27:58,470
+immunoglobulin ممكن ينتقل الى الضحية اللى هو
+
+387
+00:27:58,470 --> 00:28:01,430
+المفروض ان يكون احنا عطناه ال immunoglobulin اللى
+
+388
+00:28:01,430 --> 00:28:06,310
+حمايته احنا نقلناله ال hepatitis C لأنه هيقولنا
+
+389
+00:28:06,310 --> 00:28:09,510
+but the transmission of hepatitis C have occurred
+
+390
+00:28:09,510 --> 00:28:13,090
+حدث في الماضي يعني صار انه فيه انتقل ال hepatitis
+
+391
+00:28:13,090 --> 00:28:17,420
+CThis is the only example of an infectious disease
+
+392
+00:28:17,420 --> 00:28:22,980
+transmitted by immunoglobulin وهذا يمكن أنه
+
+393
+00:28:22,980 --> 00:28:27,200
+الفيروس الوحيد اللي تم التأكد انه انتقل عبر اللي
+
+394
+00:28:27,200 --> 00:28:31,180
+هو ال immunoglobulin اللي بنعطيها للمرضى ال
+
+395
+00:28:31,180 --> 00:28:36,340
+pathogenesis and immunity no CPEوان الكلمة No-CPE
+
+396
+00:28:36,340 --> 00:28:39,620
+يعني مافيش لنا Cytopathic Effect الـ Death بيكون
+
+397
+00:28:39,620 --> 00:28:43,380
+بالـ Cytotoxic T Cell، No Oncogene، No DNA
+
+398
+00:28:43,380 --> 00:28:46,780
+Insertion، But Hepatocellular Carcinoma Occur هذا
+
+399
+00:28:46,780 --> 00:28:49,420
+حاجة .. هي .. هي أمانا مشكلة في التفسير، احنا
+
+400
+00:28:49,420 --> 00:28:52,360
+قولنا الـ Hepatitis B، واحد، اتنين، تلاتة، طب هذا
+
+401
+00:28:52,360 --> 00:28:57,660
+مش قادرين إلا حاجة واحدة الـ Regeneration اللي هو
+
+402
+00:28:57,660 --> 00:29:02,320
+استبدال الخلالة الميتة قولنالكم بشكل سريع قد يؤدي
+
+403
+00:29:02,320 --> 00:29:08,800
+إلى حدوث خلايا سلطانيةchronic carriage of HCV أعلى
+
+404
+00:29:08,800 --> 00:29:14,240
+من مين من ال HPV 75%
+
+405
+00:29:14,240 --> 00:29:17,440
+of patients are chronically infected continue to
+
+406
+00:29:17,440 --> 00:29:21,780
+produce the virus for at least one year ال chronic
+
+407
+00:29:21,780 --> 00:29:24,280
+active hepatitis and cirrhosis occur in
+
+408
+00:29:24,280 --> 00:29:26,400
+approximately 10%
+
+409
+00:29:34,590 --> 00:29:41,090
+انتجوا الفيروس لفترة طويلة على الرغم من يعني انهم
+
+410
+00:29:41,090 --> 00:29:44,690
+لأ مش شوفيه أنا chronic هنا هم chronic وال chronic
+
+411
+00:29:44,690 --> 00:29:49,130
+غالبا يعني بتحول الفيروس الى slow growth cycle
+
+412
+00:29:49,130 --> 00:29:52,450
+يعني بيصير نمو بطيء جدا وبتالي مش infectious بيكون
+
+413
+00:29:52,450 --> 00:29:57,610
+في غالب الأمرلو شوفيا الإنسان منه بياخد جنة
+
+414
+00:29:57,610 --> 00:30:02,110
+lifelong إمني طبعا السنوات الأخيرة شهدت عقار جديد
+
+415
+00:30:02,110 --> 00:30:07,590
+اسمه Sovaldi هذا الـ Sovaldi يعني ضمن نسبة شفاء
+
+416
+00:30:07,590 --> 00:30:10,850
+عالي جدا لمرضى الهيبوتايتس و أدخل هذا العلاج قبل
+
+417
+00:30:10,850 --> 00:30:13,950
+سنة إلى جامعة مصر العربية نسأل الله لنا و لهم
+
+418
+00:30:13,950 --> 00:30:18,650
+العفو والعافية يا رب acute infection of HCV is
+
+419
+00:30:18,650 --> 00:30:23,710
+milder than HPVيعني الـ acute نفسها احنا قلنالكوا
+
+420
+00:30:23,710 --> 00:30:26,970
+انه في ال .. ال symptoms في الهيباديتس B is
+
+421
+00:30:26,970 --> 00:30:30,730
+similar to all لكن the most severe هي الأكتر شدة
+
+422
+00:30:30,730 --> 00:30:33,870
+بين الهيباديتس fever, anorexia, nausea, vomiting,
+
+423
+00:30:34,190 --> 00:30:37,130
+jaundice, dark urine, pale feces and high level of
+
+424
+00:30:37,130 --> 00:30:41,910
+transaminases هذه صارت ايش الآن سمعان ملمين لكل
+
+425
+00:30:41,910 --> 00:30:47,110
+الهيباديتس virus many acute and chronic infections
+
+426
+00:30:47,110 --> 00:30:51,350
+are asymptomatic asymptomatic يعني مافيش هنا أعرض
+
+427
+00:30:52,280 --> 00:30:56,260
+ممكن ينتج بعض الأعواد نادية عن مين عن autoimmune
+
+428
+00:30:56,260 --> 00:31:01,360
+وفي غالب الأمر نادية من ال complexes أو أن الـ
+
+429
+00:31:01,360 --> 00:31:03,820
+cytotoxic T cell هي اللي بتهاجم الخلايا
+
+430
+00:31:03,820 --> 00:31:10,720
+Similarities between HCV and HPV كلا هما بيعمل
+
+431
+00:31:10,720 --> 00:31:14,660
+chronic liver disease لكن ال HCV قُلنا هي أعلى من
+
+432
+00:31:14,660 --> 00:31:18,930
+ال HPVالتانين بيعملوا serrosis والتانين بيعملوا
+
+433
+00:31:18,930 --> 00:31:22,510
+predisposition، كلمة predisposition يعني بأهله،
+
+434
+00:31:22,510 --> 00:31:26,470
+بأهله إلى الإصابة بالهيباعت السيلولار كارسينال
+
+435
+00:31:30,490 --> 00:31:34,250
+الـ Lab Diagnosis يمكن أسهل شوية من الـ Hepatitis
+
+436
+00:31:34,250 --> 00:31:38,070
+B HCV infection is diagnosed by detecting
+
+437
+00:31:38,070 --> 00:31:43,290
+antibodies to HCV using ELISA والإيليزا فحص متوفر
+
+438
+00:31:43,290 --> 00:31:47,970
+وسهل جدا The antigen in the assay is a recombinant
+
+439
+00:31:47,970 --> 00:31:51,210
+protein formed from three immunologically stable
+
+440
+00:31:51,210 --> 00:31:56,780
+HCV proteins يعني الفقرة هي بتوصف من لغافبتوصف الـ
+
+441
+00:31:56,780 --> 00:32:00,460
+Antigen اللي أنا استخدمته في الـ ELISA للكشف عن
+
+442
+00:32:00,460 --> 00:32:04,900
+مين عن الـ Antibody انه هذا ال .. ال .. ال Antigen
+
+443
+00:32:04,900 --> 00:32:07,620
+عبارة عن Recombinant، Recombinant يعني معمول
+
+444
+00:32:07,620 --> 00:32:11,660
+بالتقنيات الهندسة الوراثية وبيمثل تلاتة
+
+445
+00:32:11,660 --> 00:32:15,440
+neurological stable HCV protein and does not
+
+446
+00:32:15,440 --> 00:32:18,820
+include the highly variable envelope protein طبعا
+
+447
+00:32:18,820 --> 00:32:21,480
+ال highly variable هيكون مختلف من إستريان إلى
+
+448
+00:32:21,480 --> 00:32:27,900
+إستريان آخرالـ test هذا لا يستطيع أن يميز بين IgM
+
+449
+00:32:27,900 --> 00:32:32,280
+وبين IgG and does not distinguish between an acute
+
+450
+00:32:32,280 --> 00:32:35,240
+chronic or resolved infection يعني مابقدرش يقوللي
+
+451
+00:32:35,240 --> 00:32:37,440
+إنه هذي acute و لا .. زي ما شفنا في ال .. في
+
+452
+00:32:37,440 --> 00:32:40,800
+Hepatitis B شفنا ال .. ال stages of the disease
+
+453
+00:32:40,800 --> 00:32:44,720
+بال marker صح؟ هذا الفحص بقوللي بست في Hepatitis C
+
+454
+00:32:45,180 --> 00:32:48,840
+انه في عنده antibodies تمام؟ هذه ال antibodies
+
+455
+00:32:48,840 --> 00:32:52,620
+بتتمدها انت الآن كطبيب correlation مع مين؟ مع ال
+
+456
+00:32:52,620 --> 00:32:57,250
+symptoms اللي موجودة عند هذا المرضيfalse positive
+
+457
+00:32:57,250 --> 00:33:01,290
+may occur وهذا الكلاب بالفعل بيحدث في ال blood
+
+458
+00:33:01,290 --> 00:33:06,470
+banks كتير من المتبرعين بتصلوا فيهم ويقولهم ماعرفش
+
+459
+00:33:06,470 --> 00:33:10,470
+تعب نعيدك الفحص مرة تانية مش متأكدين من الفحص
+
+460
+00:33:10,470 --> 00:33:14,530
+وبيعملوا confirmatory test بالرايبة حالياتي ماريكم
+
+461
+00:33:14,530 --> 00:33:18,430
+من ال immunoblot assay او بال PCR وبيعملوا
+
+462
+00:33:18,430 --> 00:33:23,850
+confirmation لهذا الحالة انه positive او negative
+
+463
+00:33:26,730 --> 00:33:30,530
+بس البصدر بده confirmation، إيش بنسمي هذا النوع من
+
+464
+00:33:30,530 --> 00:33:35,010
+الفحص؟ بيقولنا screening test ال isolation لل
+
+465
+00:33:35,010 --> 00:33:40,890
+virus is not usually performed or not done اترقبنا
+
+466
+00:33:40,890 --> 00:33:51,310
+على ال interpretation لتلت فحصاتHCV RNA PCR
+
+467
+00:33:51,310 --> 00:33:58,430
+و الـ Anti-HCV بالرايبة و الـ Anti-HCV بالإليزر No
+
+468
+00:33:58,430 --> 00:34:02,170
+infection لازم يكونوش مالهم نيجاتف في التلاتة
+
+469
+00:34:02,170 --> 00:34:06,150
+ongoing infection لازم تكون positive في التلاتة
+
+470
+00:34:10,380 --> 00:34:13,800
+Past or current infection طبعا كلمة Past or
+
+471
+00:34:13,800 --> 00:34:16,160
+current يعني أنا مش عارف، مش قادر اميز، مش قادر
+
+472
+00:34:16,160 --> 00:34:23,200
+اميز لما تكون ال HCV RNA نيجاتيف لكن بُستف لمين؟
+
+473
+00:34:23,200 --> 00:34:29,560
+ال HCV بكل من الريبا والإليزا، ليش مش قادر اميز؟
+
+474
+00:34:29,560 --> 00:34:33,860
+لأن ال Antibody موجود، و ال Antibody أنا مش قادر
+
+475
+00:34:33,860 --> 00:34:37,260
+اعرف انه IgG و لا IgM لأنه قلنا لكم في الفحص هذا
+
+476
+00:34:37,260 --> 00:34:41,330
+أحد عيوبه أنه مقدرش اميز بين التنتةماذا يعمل؟
+
+477
+00:34:41,330 --> 00:34:46,110
+additional or repeat testing should be done to
+
+478
+00:34:46,110 --> 00:34:50,330
+exclude fluctuating or low level of viremia احنا
+
+479
+00:34:50,330 --> 00:34:55,750
+قبل قليل ذكرنا ان ال viremia في هذا الفيروس هي اقل
+
+480
+00:34:55,750 --> 00:34:58,810
+من مين من ال hepatitis B إذا لو لجيت positive
+
+481
+00:34:58,810 --> 00:35:02,810
+positive و negative في ال RNA ضروري اعمل اقعد فحص
+
+482
+00:35:02,810 --> 00:35:07,910
+بعد فترة حتى اتأكد من ايش يعني fluctuation هذا
+
+483
+00:35:07,910 --> 00:35:11,880
+بالظبطفال situation معناه تذبدب، ارتفاع وانخفاض،
+
+484
+00:35:11,880 --> 00:35:18,780
+هذا اسمه تذبدب في المستوى false positive Eliza لما
+
+485
+00:35:18,780 --> 00:35:22,160
+يكون عندى positive للإليزا فقط و negative بالرايبة
+
+486
+00:35:22,160 --> 00:35:27,590
+و negative لمن؟ لل RNASituation unclear بتعرف فيها
+
+487
+00:35:27,590 --> 00:35:31,950
+حاجة اسمها cut of value في الاليزا positive او
+
+488
+00:35:31,950 --> 00:35:37,970
+negative وفي منطقة ممكن تكون محيرة في هذا الحالة
+
+489
+00:35:37,970 --> 00:35:41,330
+او بيسموها intermediate هذا ال situation بنسميه
+
+490
+00:35:41,330 --> 00:35:44,850
+unclear وبنحتاج additional testing كلمة additional
+
+491
+00:35:44,850 --> 00:35:48,950
+testing يعني بعد فترة انهيط الفحوصات مرة تانية
+
+492
+00:35:51,390 --> 00:35:58,030
+نيجاتيف HCV و Anti HCV نيجاتيف من الرعيبة لكن بصت
+
+493
+00:35:58,030 --> 00:36:03,570
+فيهاش RNA بقولنا new acute HCV او chronic HCV لانه
+
+494
+00:36:03,570 --> 00:36:10,350
+لو المريض كون antibody غالبا مش هيكون فيه الفيروس
+
+495
+00:36:10,350 --> 00:36:14,030
+تمام فاما new او chronic infection
+
+496
+00:36:18,310 --> 00:36:21,010
+الكاركترستيكس للـ Chronic Infection High
+
+497
+00:36:21,010 --> 00:36:23,730
+Transaminases Level يعني مستوى الـ Transaminases
+
+498
+00:36:23,730 --> 00:36:28,630
+بيكون عالي جدا البستفرايبة زي ما حكينا detectable
+
+499
+00:36:28,630 --> 00:36:33,290
+viral RNA for at least 6 months شبيها بمين؟ بالـ
+
+500
+00:36:33,290 --> 00:36:38,150
+Hepatitis B ال treatment and prevention فيه أنه
+
+501
+00:36:38,150 --> 00:36:42,630
+acute infectionبنستخدم لها الـ Alpha Interferon
+
+502
+00:36:42,630 --> 00:36:45,650
+كمان مرة مش علاج وانما mitigation يعني بنخفف من
+
+503
+00:36:45,650 --> 00:36:49,210
+الأعراض ال chronic infection غالبا بعضها كانوا
+
+504
+00:36:49,210 --> 00:36:53,790
+Alpha Interferon زاد Ribavirin وهذا بيقلل من ال
+
+505
+00:36:53,790 --> 00:36:56,930
+viral replication لكن لا يستطيع أنه يتخلص من مين
+
+506
+00:36:56,930 --> 00:37:01,330
+من ال career estate وأحد عيوبه أنه expensive وله
+
+507
+00:37:01,330 --> 00:37:06,570
+شوية side effect ال ribavirin alone not effective
+
+508
+00:37:06,570 --> 00:37:11,440
+لاحظوا أن ال ribavirin ما بيعملش تأثير إيجابيمافيش
+
+509
+00:37:11,440 --> 00:37:15,060
+vaccine لهذا ال virus لحد الآن وذكرنا احنا السبب
+
+510
+00:37:15,060 --> 00:37:21,240
+انه في genotypes ستة وفي many sub genotypes وهذا
+
+511
+00:37:21,240 --> 00:37:25,130
+الكلام كنا بيعقد المثالبرضه ال hyper
+
+512
+00:37:25,130 --> 00:37:27,370
+immunoglobulin are not available، ال
+
+513
+00:37:27,370 --> 00:37:30,810
+immunoglobulin not useful for post exposure
+
+514
+00:37:30,810 --> 00:37:35,270
+prophylaxis، زي مثلا اللي بنغزه إبرة، زي ما كنا في
+
+515
+00:37:35,270 --> 00:37:39,910
+اللي بدرس بيه أو في العض تبعت اللي هو ال rabies،
+
+516
+00:37:39,910 --> 00:37:43,950
+مافيش يعني إمكاني إلامن العقارين الجديدة فيها
+
+517
+00:37:43,950 --> 00:37:49,530
+اسمها semiprevar و sofsofbuvar اللي هو السوفالدي
+
+518
+00:37:49,530 --> 00:37:52,730
+تمام؟ و أحفظوه سوفالدي أسهل من اللي هو اسم العلم
+
+519
+00:37:52,730 --> 00:37:59,650
+تبعه و في دكتاليز داكلاتيزفير
+
+520
+00:37:59,650 --> 00:38:03,170
+و هذه كلها antiviral جديدة لكن أشهرهم زي ما حكينا
+
+521
+00:38:03,170 --> 00:38:07,510
+اللي هو السوفالدي العقار الذي يعني اعتبر يعني
+
+522
+00:38:07,510 --> 00:38:12,950
+إنجاز كبير للبشرية في تخلص من هذا المرضالـ
+
+523
+00:38:12,950 --> 00:38:17,610
+Hepatitis D أو الـ Delta فيروس هو عبارة عن فيروس
+
+524
+00:38:17,610 --> 00:38:21,550
+درسناها كلها تبني عرفه اسمه Delta أو Defective أو
+
+525
+00:38:21,550 --> 00:38:25,770
+D فيروس وهو Invalid فيروس Negative Since Single
+
+526
+00:38:25,770 --> 00:38:36,970
+Stranded Closely Circled RNAوهو عبارة
+
+527
+00:38:36,970 --> 00:38:41,090
+عن ريبوزايم مافيش الويريون بوليماريز الـ
+
+528
+00:38:41,090 --> 00:38:47,320
+replication بتم من خلال الـ host RNA بوليماريزالـ
+
+529
+00:38:47,320 --> 00:38:52,220
+HDV RNA ليس لديها سيكوينس هيمولوجي لـ HPV DNA يعني
+
+530
+00:38:52,220 --> 00:38:59,560
+لو أخدنا الـ RNA بتاع الـ D و قررنا سيكوينسه بالـ
+
+531
+00:38:59,560 --> 00:39:06,800
+DNA بتاع الـ D مافيش أي مقارنة بمعنى ان هما مش
+
+532
+00:39:06,800 --> 00:39:14,320
+علاقة ببعض لكن واحد معتمد على الآخرالأهم لو أنا
+
+533
+00:39:14,320 --> 00:39:18,620
+عملت vaccination للناس بهيبوتايتس B يا بنات، هل
+
+534
+00:39:18,620 --> 00:39:22,000
+فيه إمكان إنهم يصابوا بـD؟ لأ، يبقى انا ال vaccine
+
+535
+00:39:22,000 --> 00:39:26,300
+اللي عملته للـB حاملنا من B ومن مين؟ ومن D، بدون
+
+536
+00:39:26,300 --> 00:39:29,000
+قصد، ولا لأ؟ احنا مش جاسدين الـD، احنا جاسدين
+
+537
+00:39:29,000 --> 00:39:32,360
+الـB، لكن كونه الـD لا يستطيع أن يعمل infection
+
+538
+00:39:32,360 --> 00:39:36,020
+إلا في وجود B، وبالتالي احنا بنكون حاملنا الناس من
+
+539
+00:39:36,020 --> 00:39:39,190
+اتنينIt is only one single serotype, no animal
+
+540
+00:39:39,190 --> 00:39:42,670
+reservoir.الترانزميشن زي Hepatitis B بالظبط
+
+541
+00:39:42,670 --> 00:39:47,550
+Sexually, blood, perinatally ال pathogenesis and
+
+542
+00:39:47,550 --> 00:39:52,610
+immunity نفس ال HPV الدمج by cytotoxic T cell لكن
+
+543
+00:39:52,610 --> 00:39:56,110
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+544
+00:39:56,110 --> 00:39:56,110
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+545
+00:39:56,110 --> 00:39:56,510
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+546
+00:39:56,510 --> 00:39:56,550
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+547
+00:39:56,550 --> 00:39:56,730
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+548
+00:39:56,730 --> 00:39:56,730
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+549
+00:39:56,730 --> 00:39:56,730
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+550
+00:39:56,730 --> 00:40:04,590
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+551
+00:40:04,590 --> 00:40:10,620
+الليخاصة في الـ acute stage، لكن مافيش زيادة يا
+
+552
+00:40:10,620 --> 00:40:14,100
+بنات في التحول إلى chronic، مش هنقولنا 5% من
+
+553
+00:40:14,100 --> 00:40:18,520
+المرضى اللي Hepatitis B بتحول ل chronic، لو كان،
+
+554
+00:40:18,520 --> 00:40:21,460
+قالت يا معاها، دي هل بتزداد النسبة ولا بتزدادش؟
+
+555
+00:40:21,460 --> 00:40:27,200
+لأ، لأ تزداد النسبة وتبقى كما هيالـ IgG against
+
+556
+00:40:27,200 --> 00:40:30,260
+delta antigen is not detected for long period
+
+557
+00:40:30,260 --> 00:40:34,080
+after infection يعني بتطول لما يطلع فينا antibody،
+
+558
+00:40:34,080 --> 00:40:40,110
+long term immunity بتنتج لما يصير فينا antibodyزي
+
+559
+00:40:40,110 --> 00:40:43,070
+ما حكينا ال patient co-infected with both has more
+
+560
+00:40:43,070 --> 00:40:46,110
+severe symptoms ال incidence of chronic hepatitis
+
+561
+00:40:46,110 --> 00:40:50,650
+is the same in co-infection and HPV alone مافيش
+
+562
+00:40:50,650 --> 00:40:54,070
+زيادة في ال chronic infection ال lab diagnosis في
+
+563
+00:40:54,070 --> 00:40:59,890
+الكشف عن ال delta antigen او الكشف عن IgM لدلتا
+
+564
+00:40:59,890 --> 00:41:02,990
+انتجن، اذا هذا هو ال laboratory diagnosis لد
+
+565
+00:41:04,210 --> 00:41:05,910
+التريتمنت و ال prevention زي اللي بحكيها لك هو
+
+566
+00:41:05,910 --> 00:41:09,070
+مافيش أصلا إله treatment ولا إله vaccine وبالتالي
+
+567
+00:41:09,070 --> 00:41:12,990
+لك ال vaccine تبع ال B هو اللي بيحمينا من اللي هو
+
+568
+00:41:12,990 --> 00:41:17,750
+ال D أعلى شكل ل ال .. ال .. ال hepatitis B virus و
+
+569
+00:41:17,750 --> 00:41:22,190
+ال HD virus اللي طبعا الصغير ال defective بياخد
+
+570
+00:41:22,190 --> 00:41:25,990
+التاني ك helper يعني طيب الفيروس اللي قبل الأخر
+
+571
+00:41:25,990 --> 00:41:32,820
+اللي هو ال Eوالتانية يعني معرفتهم قليل عنهم واللي
+
+572
+00:41:32,820 --> 00:41:36,720
+بيشبه إلى حد كبير مين ايه فيه عملية ال
+
+573
+00:41:36,720 --> 00:41:40,740
+transmission وفيه عملية انه بتحولش إلى chronic
+
+574
+00:41:40,740 --> 00:41:47,060
+carrier تمام ولا بيترك اثار لكن بيتميز عن ايه هذا
+
+575
+00:41:47,060 --> 00:41:54,020
+ضد النساء خاصة الحواملإذا أصاب النساء الحوامل الـ
+
+576
+00:41:54,020 --> 00:41:57,740
+mortality rate بتكون عالية فقط في من في النساء
+
+577
+00:41:57,740 --> 00:42:02,780
+الحوامل أما في الغالب الأخرين بيكونوا نفس المعلومة
+
+578
+00:42:02,780 --> 00:42:07,000
+وهو Calicivirus وقلنا لكم يا بنات أطلق عليه hippie
+
+579
+00:42:07,000 --> 00:42:12,200
+virusوكلمة hippivirus من hepatitis يعني ايه ده
+
+580
+00:42:12,200 --> 00:42:16,600
+انتريك فيروس لكن او كليس فيروس لكن من صنع صنف خاص
+
+581
+00:42:16,600 --> 00:42:21,460
+بالهيباطيتس وهو non-enveloped single-stranded RNA
+
+582
+00:42:24,230 --> 00:42:28,050
+بينتقل عن طريق الـ Fecal Oral Route وبيشبه
+
+583
+00:42:28,050 --> 00:42:32,790
+Hepatitis A جنه في خاصتين لدى الفيروس طبعا زى ما
+
+584
+00:42:32,790 --> 00:42:37,310
+ذكرنا الاختلاف الأساسى اللى هو النساء الحوامل اللى
+
+585
+00:42:37,310 --> 00:42:43,050
+مرتبطة فيهم حالي لـ Hepatitis A ال test للـ HEV
+
+586
+00:42:43,050 --> 00:42:46,750
+antibody is not available for diagnosis يعني مافيش
+
+587
+00:42:46,750 --> 00:42:51,950
+أن افحص وبالتالي بتتم العملية من خلالالتشخيص يتم
+
+588
+00:42:51,950 --> 00:42:55,470
+من خلال استثناء كيف الاستثناء؟ انا عندي خمس او ست
+
+589
+00:42:55,470 --> 00:43:00,310
+انواع من الهيباديتس A negative B negative طبعا اذا
+
+590
+00:43:00,310 --> 00:43:04,090
+B negative اكيد بيبحثش لمين؟ بيبحثش لديه .. ل .. ل
+
+591
+00:43:04,090 --> 00:43:05,170
+.. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل
+
+592
+00:43:05,170 --> 00:43:05,250
+.. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل
+
+593
+00:43:05,250 --> 00:43:05,270
+.. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل
+
+594
+00:43:05,270 --> 00:43:05,370
+.. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل
+
+595
+00:43:05,370 --> 00:43:06,010
+.. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل
+
+596
+00:43:06,010 --> 00:43:06,710
+.. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل
+
+597
+00:43:06,710 --> 00:43:14,090
+.. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل .. ل ..
+
+598
+00:43:14,090 --> 00:43:22,810
+ل .. لThere is no antiviral treatment or vaccine
+
+599
+00:43:22,810 --> 00:43:28,590
+هو من الاخير هذا من Hepatitis G virus بينتمي ل
+
+600
+00:43:28,590 --> 00:43:30,830
+Flavivirus أكمل Flavivirus صار عندنا في Hepatitis
+
+601
+00:43:30,830 --> 00:43:34,870
+V virus اتنين اللي هم Hepatitis C و Hepatitis LG
+
+602
+00:43:34,870 --> 00:43:39,150
+It can cause chronic infection lasting for decades
+
+603
+00:43:39,150 --> 00:43:46,620
+استمر لعشرات السنوات الآن طلعوا الرقم الكبير60-70%
+
+604
+00:43:46,620 --> 00:43:49,740
+of those infected clear the virus and develop
+
+605
+00:43:49,740 --> 00:43:56,020
+antibodies يبقى قدش تراندي 30-40% من المرضى قد
+
+606
+00:43:56,020 --> 00:44:00,360
+يتحولوا إلى chronic infection مدى فقط 60-70% اللي
+
+607
+00:44:00,360 --> 00:44:04,760
+بيخلصونا من مين بتخلصه من ال virus يبقى 30-40% قد
+
+608
+00:44:04,760 --> 00:44:10,820
+يصابوا ب .. تقولنا اللي هو chronic infectionHGV is
+
+609
+00:44:10,820 --> 00:44:13,960
+transmitted via sexual intercourse and blood هذا
+
+610
+00:44:13,960 --> 00:44:19,720
+بيختلف عن الـ C الـ C مين فقط ال blood هذا ممكن
+
+611
+00:44:19,720 --> 00:44:23,420
+تقل بسهولة عن ال sexual intercourse فيه معلومة
+
+612
+00:44:23,420 --> 00:44:29,260
+حلوة كتير عجيبة لو مريض aids أصيب بيه hepatitis G
+
+613
+00:44:29,260 --> 00:44:34,140
+بنلاقي أن أعراض ال aids في هذا المريض أخفماذا
+
+614
+00:44:34,140 --> 00:44:37,720
+رأيكم؟ يعني اللي ممكن نستخدمه إيه؟ نستخدمه كعلاج
+
+615
+00:44:37,720 --> 00:44:43,320
+لمرضى ال aids و تطلع كمان معلومة عن have less HIV
+
+616
+00:44:43,320 --> 00:44:46,720
+in their blood واضح أن الفيروس اللي ممكن بيعمل
+
+617
+00:44:46,720 --> 00:44:52,940
+interference مع مين؟ مع اللي هو ال HIV virusوبهذا
+
+618
+00:44:52,940 --> 00:44:58,200
+يعني ننهي ال course ان شاء الله اللي هو ال biology
+
+619
+00:44:58,200 --> 00:45:02,960
+واتمنى ان اتقدم لكم يعني ب .. ببعض الكلمات ال ..
+
+620
+00:45:02,960 --> 00:45:06,960
+الأخيرة في هذا ال course طبعا كنتم يعني جمهور
+
+621
+00:45:06,960 --> 00:45:10,340
+محترم وجيد وانا سعيد جدا بان ادرسكم هذا الفصل
+
+622
+00:45:10,340 --> 00:45:14,070
+الحقيقي دل مرة ثالثة الآنessential و diagnostic
+
+623
+00:45:14,070 --> 00:45:19,830
+way اللي هو ال biology في نهاية الفصل بتقدم لكم
+
+624
+00:45:19,830 --> 00:45:23,870
+كمان مرة بجديل الشكر و بتقدم لكم بخالص الدعاء
+
+625
+00:45:23,870 --> 00:45:27,610
+والتمانية ان شاء الله بإن يعني يكون وفقنا في هذا
+
+626
+00:45:27,610 --> 00:45:32,110
+ال course إلى إيصال معلومات وافية وكافية عن course
+
+627
+00:45:32,110 --> 00:45:36,490
+الفيروسات لكن ما أود أن أقوله حقيقة أن أنا في
+
+628
+00:45:36,490 --> 00:45:41,380
+فلسطينفي قطاع غزة بالذات و تحت ضل هذه الظروف التي
+
+629
+00:45:41,380 --> 00:45:46,740
+نحياها لابد لنا أن نقدم شيء لمجتمعاتنا عارفين احنا
+
+630
+00:45:46,740 --> 00:45:51,240
+بنجرش نقدم لمجتمعاتنا؟ بنقدم لهم خدمة أمينة خدمة
+
+631
+00:45:51,240 --> 00:45:55,900
+جيدة والخدمة الأمينة والجيدة تتطلب مننا أن نكون
+
+632
+00:45:55,900 --> 00:46:02,450
+احنا اصلا مهرم انكون عندنا قدرات علميةما نشتغل شغل
+
+633
+00:46:02,450 --> 00:46:07,010
+غير علمي ونقدمه للناس، كثير من الخزعبالات وكثير من
+
+634
+00:46:07,010 --> 00:46:11,510
+التجاوزات اللي موجودة في قطاع المختبرات الطبية
+
+635
+00:46:11,510 --> 00:46:15,710
+موجودة في مجتمعنا، لذلك نرجو من حضرتكم أن تتعلموا
+
+636
+00:46:15,710 --> 00:46:19,300
+باستمرار، تتعلموا مستمر، إيه تتعلموا مستمر؟يعني
+
+637
+00:46:19,300 --> 00:46:22,860
+بعد ما نتخرج ما .. خلاص اننا والله هنهينا العلم
+
+638
+00:46:22,860 --> 00:46:25,680
+وانتهينا من الموضوع كل يوم بطلع جديد اللي أنا
+
+639
+00:46:25,680 --> 00:46:29,520
+درسته في ال immunology لا يساوي واحد على عشرين او
+
+640
+00:46:29,520 --> 00:46:33,120
+تلاتين من اللي الآن بندرسه في ال virology من
+
+641
+00:46:33,120 --> 00:46:37,440
+المناعة العلم بتتطور و بتزداد وبالتالي لابد ان
+
+642
+00:46:37,440 --> 00:46:41,820
+احنا نتطور هنقدر نجدم خدمة جيدة لأبناء عشانها شكرا
+
+643
+00:46:41,820 --> 00:46:42,600
+و أعطيكم ألف عافية
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LIgItABBP8U.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LIgItABBP8U.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2fd8a5071c7d7d4759a747363bfcf6b2dc13cd5d
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LIgItABBP8U.srt
@@ -0,0 +1,1983 @@
+1
+00:00:21,360 --> 00:00:24,560
+طيب بسم الله الرحمن الرحيم احنا المحاضرة الماضية
+
+2
+00:00:24,560 --> 00:00:29,940
+بدأنا بالحديث عن فيروس مهم جدا قلنا اللي هو فيروس
+
+3
+00:00:29,940 --> 00:00:33,260
+الـHIV وذكرنا أن هذا الفيروس ينتمي لعائلة ال
+
+4
+00:00:33,260 --> 00:00:37,040
+retroviruses اللي هي مكونة من ثلاث sub families
+
+5
+00:00:37,040 --> 00:00:42,580
+واحدة منهم الـLentiviruses و Lentiviruses هي اللي
+
+6
+00:00:42,580 --> 00:00:47,840
+ينتمي لها قولنا الـHIV وتحدثنا عن صنفين HIV-1 و HIV-2
+
+7
+00:00:47,840 --> 00:00:51,980
+وميزنا بينهم في بعض الصفات كلمنا برضه عن بعض التراكيب
+
+8
+00:00:51,980 --> 00:00:56,140
+المهمة جدا في الـHIV مثل الـstructural genes زي الـ
+
+9
+00:00:56,140 --> 00:00:59,820
+pol و الـgag و الـenv واتكلمنا عن بعض اللي هم الـ
+
+10
+00:00:59,820 --> 00:01:03,260
+regulatory genes و الـnon essential genes وشوفنا
+
+11
+00:01:03,260 --> 00:01:06,140
+الـfunctions تبعت كل واحد من هذه الجينات على الأقل
+
+12
+00:01:06,810 --> 00:01:10,050
+وبعدين انتقلنا إلى الـdiseases associated with
+
+13
+00:01:10,050 --> 00:01:14,270
+HIV وجسمناها على الـlungs و الـ...الـ...الدم و الـ
+
+14
+00:01:14,270 --> 00:01:17,670
+skin و الـ...يعني الـgastrointestinal فصلة تقريبا
+
+15
+00:01:17,670 --> 00:01:20,590
+تفصيل فيها كبيرة، اللي هنا هنتكلم...هنكمل إن شاء
+
+16
+00:01:20,590 --> 00:01:25,470
+الله ونشوف الـpath genesis تبع الـHIV من الـ
+
+17
+00:01:25,470 --> 00:01:27,010
+characteristics أنه بيعمل infection إلى الـ
+
+18
+00:01:27,010 --> 00:01:31,910
+lymphocyte و الـmacrophages هذا أو هذه الخاصية
+
+19
+00:01:31,910 --> 00:01:36,830
+تجعل من هذا الفيروس قاتل للخلايا للخلايا من؟ للخلايا ال
+
+20
+00:01:36,830 --> 00:01:41,690
+immune system المتمثل في الـCD4 cells وكمان شوية
+
+21
+00:01:41,690 --> 00:01:46,990
+هنشوف احنا الـcourse على الـHIV عندما يبدأ الـ
+
+22
+00:01:46,990 --> 00:01:52,430
+disease بيبدأ silent ساكن وممكن يستمر لسنوات ساكن
+
+23
+00:01:52,430 --> 00:01:58,710
+متى بتبدأ الأعراض عندما ينخفض عدد الـCD4 في الدم
+
+24
+00:01:58,710 --> 00:02:05,390
+تمام إلى مستوى معين وهو 200 خلية per milliliter
+
+25
+00:02:05,390 --> 00:02:08,110
+بيبدأ الأعراض تبع الـHIV تظهر
+
+26
+00:02:16,090 --> 00:02:20,290
+هذا يؤدي إلى inactivation of CD4 helper T cells، طب
+
+27
+00:02:20,290 --> 00:02:22,870
+لما نعمل inactivation لـhelper T cells، مجرد حاجة
+
+28
+00:02:22,870 --> 00:02:27,990
+أنه جزء كبير من الـactivator immune cells بتروح
+
+29
+00:02:27,990 --> 00:02:31,430
+وبالتالي بالفعل بصرف النظر عن خفض فيما يسمى بالـ
+
+30
+00:02:31,430 --> 00:02:34,410
+delayed type hypersensitivity و الـdelayed type
+
+31
+00:02:34,410 --> 00:02:39,050
+hypersensitivity هي cell mediated immunity لكثير
+
+32
+00:02:39,050 --> 00:02:41,850
+من الـintracellular pathogen زي البكتيريا و
+
+33
+00:02:41,850 --> 00:02:46,670
+الفيروس لكمان الفيروس اللي مقدر على نعمل تغيير في
+
+34
+00:02:46,670 --> 00:02:49,070
+الـ...نعمل antigenic drift فاكرين الـdrift و
+
+35
+00:02:49,070 --> 00:02:53,370
+shift؟ الـdrift تغيير طفيف...تغيير طفيف في اللى
+
+36
+00:02:53,370 --> 00:02:57,190
+هو الـglycoprotein 120 اللي هو المسؤول عن مين؟ عن
+
+37
+00:02:57,190 --> 00:03:01,430
+الارتباط هذا التغيير كافي إنه ما يتعرفش على الـ
+
+38
+00:03:01,430 --> 00:03:05,990
+antibody اللي اتكون بالأول، لكن غير كافي إنه يمنع
+
+39
+00:03:05,990 --> 00:03:10,150
+ارتباطه بمين؟ بالـCD4، يعني ما اتغيرش بشكل
+
+40
+00:03:10,150 --> 00:03:15,290
+دراماتيكي، اتغير بشكل طفيف، خدع الـantibody، لكن
+
+41
+00:03:15,290 --> 00:03:19,750
+ما زال قادر على ارتباطه بمين؟ مع الـCD4 في كمان
+
+42
+00:03:19,750 --> 00:03:22,810
+شغل تاني في الجسم نفسه في جسم الإنسان بيعمل
+
+43
+00:03:22,810 --> 00:03:26,570
+حاجة glycosylation أو heavy glycosylation للـ
+
+44
+00:03:26,570 --> 00:03:30,910
+GP120 اللي هو الـ...الـ...الـ...الـreceptor اللي
+
+45
+00:03:30,910 --> 00:03:33,610
+موجه على الـHIV، إيش يعني heavy glycosylation؟
+
+46
+00:03:33,610 --> 00:03:37,710
+يعني بيعمل له masking، إيش يعني masking؟ يعني زي لما
+
+47
+00:03:37,710 --> 00:03:42,370
+احنا بنحط الجلم وبنحط له غطا، هو حط غطا لمين؟ للـ
+
+48
+00:03:42,370 --> 00:03:47,810
+GP120 هذا الغطاء بيعمل بيمنع برضه الـantibodies اللي
+
+49
+00:03:47,810 --> 00:03:53,610
+اتكونت لهذا specifically لهذا الـGlycoprotein إنه
+
+50
+00:03:53,610 --> 00:03:59,090
+يرتبط فيه، إذن الـHIV عنده طرق لخداع جهاز المناعة
+
+51
+00:03:59,090 --> 00:04:05,850
+بشكل قوي جدا من خلال أولا الارتباط وعصابة كل من
+
+52
+00:04:05,850 --> 00:04:09,910
+الـCD4 والماكروفاج، رقم اثنين inactivation of CD4،
+
+53
+00:04:09,910 --> 00:04:15,550
+رقم ثلاثة اللي هو الـantigenic drift للـGP120
+
+54
+00:04:15,550 --> 00:04:18,430
+بالإضافة إلى الـheavy glycosylation أو الـmasking
+
+55
+00:04:18,430 --> 00:04:20,390
+للـGP120
+
+56
+00:04:22,370 --> 00:04:27,910
+طبعا الـhuman herpes virus type 8 درسناها في الـ
+
+57
+00:04:27,910 --> 00:04:30,410
+DNA virus اللي تكلمنا عنه الـherpes viruses و
+
+58
+00:04:30,410 --> 00:04:34,130
+اتكلمنا عن الـKaposi's sarcoma و الـKaposi's sarcoma
+
+59
+00:04:34,130 --> 00:04:37,830
+واحدة من أهم الـindicators أن هذا الإنسان قد
+
+60
+00:04:37,830 --> 00:04:44,140
+يكون مصاب بمرض الـAIDS أو الـHIV الـAIDS
+
+61
+00:04:44,140 --> 00:04:49,380
+Epidemiology بينقسم لثلاث أقسام طرق الانتقال إما
+
+62
+00:04:49,380 --> 00:04:54,400
+عن طريق الـblood and blood products أو عن طريق الـ
+
+63
+00:04:54,400 --> 00:04:57,900
+vertical transmission أو رقم واحد اللي هي الـ
+
+64
+00:04:57,900 --> 00:05:01,600
+sexual transmission والحقيقة إنهم مرتبين تقريبا
+
+65
+00:05:01,600 --> 00:05:06,360
+بنفس اللي هو الأهمية الـsexual transmission اللي
+
+66
+00:05:06,360 --> 00:05:10,400
+لجوه إنه في الذكور المخنثين اللي هم اللي بيسموهم
+
+67
+00:05:10,400 --> 00:05:11,160
+homosexual
+
+68
+00:05:13,430 --> 00:05:21,390
+هم بشكل أكبر فئة معرضة للإصابة بالـHIV في
+
+69
+00:05:21,390 --> 00:05:24,650
+الولايات المتحدة وأوروبا لكن في الدول النامية
+
+70
+00:05:24,650 --> 00:05:29,670
+الرجال العاديين اللي هو الـheterosexual منهم أكثر
+
+71
+00:05:29,670 --> 00:05:33,770
+فئة يصابوا إذا بدنا نتفق على أن الـsexual
+
+72
+00:05:33,770 --> 00:05:38,170
+transmission هو أداة رئيسية لانتقال الـHIV
+
+73
+00:05:40,740 --> 00:05:42,860
+الطريقة الثانية اللي هي الـblood and blood
+
+74
+00:05:42,860 --> 00:05:46,580
+products وكلمة blood products يعني بدل ما أعطي
+
+75
+00:05:46,580 --> 00:05:48,920
+whole blood بأعطي مثلا الـplatelet concentrate
+
+76
+00:05:48,920 --> 00:05:52,040
+بأعطي factors معينة coagulation factors لبعض
+
+77
+00:05:52,040 --> 00:05:55,480
+المرضى هذا بيسموها blood product بأعطي بلازما لحال
+
+78
+00:05:56,700 --> 00:06:00,680
+لكن في نقطة مهمة جدا قبل ما نتكلم عن الـblood bags
+
+79
+00:06:00,680 --> 00:06:03,840
+و الـblood products نتكلم عن الـIV drug users اللي
+
+80
+00:06:03,840 --> 00:06:07,180
+هم مدمني المخدرات اللي بيحقنوا أنفسهم جننا بيه
+
+81
+00:06:07,180 --> 00:06:13,320
+بمخدرات وبيشاركوا في القنوات طبعا هدول لما نقول drug
+
+82
+00:06:13,320 --> 00:06:18,010
+abusers هذا مش دمهم الوحيد خدوا بالكم كالخمر الخمر
+
+83
+00:06:18,010 --> 00:06:21,350
+طوله بالعقل فإذا دعا بالعقل يرتكب الإنسان كل
+
+84
+00:06:21,350 --> 00:06:26,190
+الفواحش ومن ضمنها الزنا واللواط وغيره وبالتالي
+
+85
+00:06:26,190 --> 00:06:31,630
+هؤلاء الناس لديهم برضه فرصة عالية لاكتساب هذا
+
+86
+00:06:31,630 --> 00:06:35,050
+المرض إما من خلال مشاركة الإبر أو من خلال الأفعال
+
+87
+00:06:35,050 --> 00:06:42,620
+الأخرى التي يقومون بها في الفئات اللي ظهر أنها high
+
+88
+00:06:42,620 --> 00:06:45,880
+risk group الناس اللي عندهم hemophilia واللي عندهم
+
+89
+00:06:45,880 --> 00:06:51,020
+hemophilia دائما بيعطوا factor ثمانية وهو يعني
+
+90
+00:06:51,020 --> 00:06:55,180
+يفصل من الـblood bags ويعطيه خصيصا لهؤلاء المرضى
+
+91
+00:06:55,180 --> 00:06:59,280
+وبالتالي هدول الناس كانوا عرضة للإصابة بالـHIV قبل
+
+92
+00:06:59,280 --> 00:07:02,960
+ما يدخل عملية الفحوصات للـHIV في الـblood bags
+
+93
+00:07:02,960 --> 00:07:08,300
+ثلاثة Vertical Transmission طلعوا ليها الجملة اللي
+
+94
+00:07:08,300 --> 00:07:13,340
+في سطر اثنين وأنها varies from around 15% in
+
+95
+00:07:13,340 --> 00:07:18,760
+western Europe to up to 50% in Africa الآن البعض
+
+96
+00:07:18,760 --> 00:07:22,360
+على طول بينظر لمن؟ للجغرافيا صح ولا لا؟ بما أننا
+
+97
+00:07:22,360 --> 00:07:26,620
+نتكلم عن أوروبا ونتكلم عن أفريقيا شمالها 15% في
+
+98
+00:07:26,620 --> 00:07:31,840
+أوروبا لانتقال من الأم إلى المولود وفي أفريقيا تصل
+
+99
+00:07:31,840 --> 00:07:37,770
+إلى 50% هل هذا الكلام له علاقة بالجغرافيا؟ قد
+
+100
+00:07:37,770 --> 00:07:42,630
+يكون له علاقة بتطور الطب في المنطقتين يعني هذا في
+
+101
+00:07:42,630 --> 00:07:47,210
+أوروبا الأم الحامل المصابة بالـHIV تعطى drugs لمنع
+
+102
+00:07:47,210 --> 00:07:51,730
+انتقال الفيروس من الـ...أو تقليل فرص انتقال
+
+103
+00:07:51,730 --> 00:07:55,610
+الفيروس إلى اللي هو المولود وبالتالي النسبة بتكون
+
+104
+00:07:55,610 --> 00:08:00,790
+إيه؟  أقل  فرح الـHIV بينتقل من
+
+105
+00:08:00,790 --> 00:08:05,390
+transplacentally خلال الولادة أو حتى من الـbreast
+
+106
+00:08:05,390 --> 00:08:09,110
+milk يعني الـbreast feeding من الرضاعة الطبيعية
+
+107
+00:08:09,110 --> 00:08:14,290
+لذلك الأم المصابة بالـHIV كإجراء وقاية يجب أن تمنع
+
+108
+00:08:14,290 --> 00:08:18,190
+من إرضاع طفلها رضاعة طبيعية وزي ما حكينا إذا كانت
+
+109
+00:08:18,190 --> 00:08:21,950
+معروفة ومشخصة يمكن أن تعطى بعض العقاقير لمنع
+
+110
+00:08:21,950 --> 00:08:29,320
+الانتقال إلى اللي هو الموضوع الـtreatment للـHIV
+
+111
+00:08:29,320 --> 00:08:32,240
+طبعا أنا ما بديش أدوشكم كتير في موضوع الـ
+
+112
+00:08:32,240 --> 00:08:36,380
+treatment لكن احنا مجبرين رصبا عندنا في الـHIV أن
+
+113
+00:08:36,380 --> 00:08:41,740
+نتكلم عن الـtreatment لأن أكثر الفيروسات المدروسة
+
+114
+00:08:41,740 --> 00:08:46,510
+واللتي  بوحي  تلها عن عقاقير يعني هنحاول قدر الامكان
+
+115
+00:08:46,510 --> 00:08:52,270
+نقتصر الـtreatment في بعض الصفحات البسيطة لكن
+
+116
+00:08:52,270 --> 00:08:56,330
+رأيها الأمر أن هو بالفعل الـHIV محتل مساحة ضخمة من
+
+117
+00:08:56,330 --> 00:09:04,300
+الـantiviral drugs فيها سماعات HAART مش بالقلب يعني
+
+118
+00:09:04,300 --> 00:09:10,860
+وإنما HAART وتعني highly active وكلمة highly
+
+119
+00:09:10,860 --> 00:09:14,980
+active يعني ذو فعالية عالية anti-viral therapy عرفنا إيش يعني HAART؟ Highly Active Anti
+
+120
+00:09:18,720 --> 00:09:24,840
+-Retroviral Therapy المقصود فيها أنه علاج للـ
+
+121
+00:09:24,840 --> 00:09:30,720
+retrovirus الـHIV و highly active يعني فعال جدا
+
+122
+00:09:30,720 --> 00:09:36,880
+كلمة فعال جدا زي مصطلحاتنا لمعاهد قصير كتير بيشوف
+
+123
+00:09:36,880 --> 00:09:40,580
+واحد أطول منه بشوية إيش بيقول عنه؟ طويل جدا
+
+124
+00:09:40,580 --> 00:09:45,880
+فالمقارنة هنا نسبية كلهم قصير لو واحد طويل عادي أو 
+
+126
+00:09:45,880 --> 00:09:48,840
+لو واحد normal بيقول اثنين ايش بالهم اثنين جسور
+
+127
+00:09:48,840 --> 00:09:54,700
+لكن الجسير بيشوف الطويل بيقول عنه طويل جدا، مظبوط؟
+
+128
+00:09:54,700 --> 00:09:59,280
+إذن هذا مصطلح qualitative مش quantitative أو semi
+
+129
+00:09:59,280 --> 00:10:06,470
+quantitative مش relative مش absolute وبالتالي نعني
+
+130
+00:10:06,470 --> 00:10:10,270
+فيه أن هذا العلاج هو من أفضل العلاجات التي 
+
+131
+00:10:10,270 --> 00:10:14,630
+استخدمناها على من للـ HIV مقارنة بما هو متوفر
+
+132
+00:10:14,630 --> 00:10:23,870
+وتكون من زيدوفيودين ولمفيودين وهاتان عبارة عن
+
+133
+00:10:23,870 --> 00:10:27,410
+نوكليوسايد إنّهيبتر وعارفين يعني نوكليوسايد
+
+134
+00:10:27,410 --> 00:10:27,910
+إنّهيبتر
+
+135
+00:10:32,170 --> 00:10:36,010
+الـ Transcription أو الـ Replication تمام؟ عندما
+
+136
+00:10:36,010 --> 00:10:39,390
+يركب نوكليوسايد معينة يوقفوها فبالتالي يوقفوا
+
+137
+00:10:39,390 --> 00:10:42,450
+عملية الـ Transcription و Trans... لماذا؟ بالإضافة
+
+138
+00:10:42,450 --> 00:10:46,350
+إلى ما يسمى بـ Protease Inhibitor كلكم تعرفون أن
+
+139
+00:10:46,350 --> 00:10:49,690
+الريتروفيروس يتميز بأنه ينتج الـ precursor
+
+140
+00:10:49,690 --> 00:10:53,050
+polypeptide والـ precursor polypeptide  لعمل
+
+141
+00:10:53,050 --> 00:10:58,460
+يحتاج Protease ويبقى فيه Protease إذا استطعت أنا أن
+
+142
+00:10:58,460 --> 00:11:02,200
+أنا أقوم بـ inhibition لها  لبروتياز فأنا أمنع تكسير
+
+143
+00:11:02,200 --> 00:11:05,460
+الـ precursor polypeptide وبالتالي لا يخرج functional
+
+144
+00:11:05,460 --> 00:11:08,380
+protein بوجه الـ replication تبع الفيروس، إذن
+
+145
+00:11:08,380 --> 00:11:13,370
+البروتياز إنّهيبتر فكرة عظيمة دمجناها مع two
+
+146
+00:11:13,370 --> 00:11:19,370
+nucleoside inhibitors تشكل لنا علاجاً أو خذنا نقول
+
+147
+00:11:19,370 --> 00:11:25,630
+وصفة regimen علاجية للـHIV سميناها highly active
+
+148
+00:11:25,630 --> 00:11:30,010
+antiretroviral therapy ال... ال... الـ protein
+
+149
+00:11:30,010 --> 00:11:34,270
+inhibitor اسمه Indenavir Indenavir وزيدوفيودين
+
+150
+00:11:34,270 --> 00:11:36,530
+وقلنا التي لهم فيودين هؤلاء هم الـ nucleoside
+
+151
+00:11:36,530 --> 00:11:41,080
+inhibitors من مزاياها أنها effective in prolonging
+
+152
+00:11:41,080 --> 00:11:45,180
+life ماذا يعني in prolonging life يطول الأمر؟ طب
+
+153
+00:11:45,180 --> 00:11:47,920
+أحنا فينا في ال... في ال... في الإسلام حد يطول
+
+154
+00:11:47,920 --> 00:11:52,220
+الأمر؟ ماذا رأيكم؟ لا ما هو الثاني... الثاني غيب
+
+155
+00:11:52,220 --> 00:11:56,860
+الثاني improving quality of life هذه موجودة  لكن الـ
+
+156
+00:11:56,860 --> 00:12:03,290
+prolonging life في حد يقدر يمد أمر  حدّه  هو المصطلح
+
+157
+00:12:03,290 --> 00:12:07,730
+... المصطلح فيه ظاهري يبدو أن فيه خلال لكن في...
+
+158
+00:12:07,730 --> 00:12:10,530
+في بعض ما أمر طبيعي  أحنا حد فينا يعرف أصلاً  جدش 
+
+159
+00:12:10,530 --> 00:12:14,470
+الأمر وابتداءً ما يعرفش أحنا كيف يحسبوا... يحسبوا
+
+160
+00:12:14,470 --> 00:12:17,510
+أو يقولوا هذه الجملة effective in prolonging life
+
+161
+00:12:17,510 --> 00:12:21,750
+يقولون أن مثلاً من دخول الأعراض إلى الوفاة بدون 
+
+162
+00:12:21,750 --> 00:12:27,870
+علاج X بدون علاج Y X بدون علاج Z X يعني في أندي
+
+163
+00:12:27,870 --> 00:12:31,390
+فترات معينة من... من بداية دخول الأعراض إلى الوفاة
+
+164
+00:12:32,180 --> 00:12:36,700
+الذي قال لو استخدمت أنا علاج وأعطاني مع مجموعة من
+
+165
+00:12:36,700 --> 00:12:42,040
+المرضى فترة عمر أطول، عاشوا أطول، فأجيب الفترة
+
+166
+00:12:42,040 --> 00:12:46,700
+التي عاشوها أطول وأقول أنه زود عمر المرضى بشهرين،
+
+167
+00:12:46,700 --> 00:12:50,720
+بسنتين، بعشرين سنة، تمام؟ يبقى هذا المصطلح فيه
+
+168
+00:12:50,720 --> 00:12:55,210
+الذي أسميه هنا prolonging life improving quality of
+
+169
+00:12:55,210 --> 00:12:59,650
+life تحسين جودة الحياة طبعاً حياة مرضى الـ aids حياة
+
+170
+00:12:59,650 --> 00:13:05,150
+عذاب كل الميكروبات التي في الدنيا سواء كان ممرضة
+
+171
+00:13:05,150 --> 00:13:09,310
+أو غير ممرضة تعمل لهم أمراض إبتلاء هو always sick
+
+172
+00:13:09,310 --> 00:13:14,400
+ما فيه عنده يعني وقت ما فيه sick لكن وجود هذا الـ
+
+173
+00:13:14,400 --> 00:13:20,100
+Drug رفع من الذي هو الـ CD4 count إلى أكثر من 200
+
+174
+00:13:20,100 --> 00:13:23,760
+وبالتالي قلل من إمكانية الذي هو الـ infection
+
+175
+00:13:23,760 --> 00:13:28,000
+فأعطاه يعني بعض الفترات التي هو ممكن ما كانش فيها
+
+176
+00:13:28,000 --> 00:13:34,180
+مريض بمرض آخر Reducing viral load هذا مؤشر على أنه
+
+177
+00:13:34,180 --> 00:13:41,160
+المريض يستجيب لهذا العلاج الـ disadvantage طبعاً زي
+
+178
+00:13:41,160 --> 00:13:44,420
+كل الـ antiviral drugs أن does not cure the
+
+179
+00:13:44,420 --> 00:13:53,280
+chronic HIV infection أحنا قلنا فيها أن ال... ال...
+
+180
+00:13:53,280 --> 00:13:57,120
+... الـ heart في كلمة heart بس أستخدمها للـ children
+
+181
+00:13:57,930 --> 00:14:04,410
+مكوّن من زيدوفيودين ولموفيودين بالإضافة
+
+182
+00:14:04,410 --> 00:14:07,850
+إلى non-nucleoside
+
+183
+00:14:07,850 --> 00:14:13,290
+reverse transcriptase inhibitors اسمه EVA virans
+
+184
+00:14:17,100 --> 00:14:21,820
+البروتياز إنّهيبتر آخر غير الأولاني اسمه Nelfenadir
+
+185
+00:14:21,820 --> 00:14:26,420
+أضفناه لهذه المجموعة يقول أن يعمل enhancement
+
+186
+00:14:26,420 --> 00:14:32,500
+للـ potency والـ duration of the antiviral effect in
+
+187
+00:14:32,500 --> 00:14:38,300
+children نستطيع أن نقول أن الـ HAART الآن ليس مجرد وصفة
+
+188
+00:14:38,300 --> 00:14:42,260
+واحدة ولا بأكثر من وصفة لكن هي عبارة عن من؟ عن
+
+189
+00:14:42,260 --> 00:14:46,800
+خلطة من بعض العقاقير الـ antiviral غالباً from two
+
+190
+00:14:46,800 --> 00:14:50,360
+to three classes ماذا يعني الـ two to three classes؟
+
+191
+00:14:50,360 --> 00:14:54,320
+يعني من صنفين أو من ثلاث أصناف من العقاقير شفنا
+
+192
+00:14:54,320 --> 00:14:58,040
+نوكليوسايد إنّهيبتر مظبوط شفنا التي بروتيز
+
+193
+00:14:58,040 --> 00:15:02,200
+إنّهيبتر شفنا الآن التي هم non-nucleoside reverse
+
+194
+00:15:02,200 --> 00:15:07,850
+transcriptase inhibitors مزمنة في الـ treatment
+
+195
+00:15:07,850 --> 00:15:12,110
+زيدوفيودين والأزيدوثايميدين  يُثبّط HIV
+
+196
+00:15:12,110 --> 00:15:16,770
+replication by interfering with proviral DNA
+
+197
+00:15:16,770 --> 00:15:21,450
+synthesis من يتذكر ماذا يعني proviral DNA synthesis
+
+198
+00:15:21,450 --> 00:15:28,010
+أو proviral؟ عندما أذكركم في الـ prophage الـ prophage
+
+199
+00:15:28,010 --> 00:15:31,330
+هو الـ DNA الذي صار له integration في الـ host
+
+200
+00:15:31,330 --> 00:15:37,030
+فبالتالي هذا الذي هو الـ DNA تبع الـ HIV الذي صار له
+
+201
+00:15:37,030 --> 00:15:41,090
+integration في الـ host DNA أي اسمه proviral DNA
+
+202
+00:15:41,090 --> 00:15:46,210
+الذي نحن نقول ZWD والـ ZYD كلاهما يعمل
+
+203
+00:15:46,210 --> 00:15:49,410
+inhibition للـ replication من خلال الـ interference
+
+204
+00:15:49,410 --> 00:15:55,630
+مع هذا الذي هو الـ DNA لكن للأسف لا يستطيعون أن
+
+205
+00:15:55,630 --> 00:16:01,190
+يقوموا بـ curing لخلايا already فيها الذي هو الـ
+
+206
+00:16:01,190 --> 00:16:06,470
+provirus لماذا؟ هم يمنعون الـ replication تبعه، ولكن
+
+207
+00:16:06,470 --> 00:16:11,050
+لا يستطيعون إزالته من مكانه، لا يستطيعون نزعه من مكانه بتاعه
+
+208
+00:16:11,050 --> 00:16:15,970
+يبقى له موجود يعني لو انتهت الدواء، راح تأثير العقار،
+
+209
+00:16:15,970 --> 00:16:21,880
+يرجع الـ DNA يتكاثر مرة أخرى Strains of HIV
+
+210
+00:16:21,880 --> 00:16:25,500
+resistant to ZDV الذي هو الذي قلنا عنه Zidovudine
+
+211
+00:16:25,500 --> 00:16:29,380
+have been isolated from patients receiving long
+
+212
+00:16:29,380 --> 00:16:33,120
+term ZDV therapy، إذن زي زي البكتيريا، يعني تستطيع
+
+213
+00:16:33,120 --> 00:16:36,300
+أنا برضه مالها أنها تقاوم الذي هو أو تبقى
+
+214
+00:16:36,300 --> 00:16:41,980
+resistant للعقاقير أيضاً الـ Zidovudine عنده effects
+
+215
+00:16:41,980 --> 00:16:48,980
+هيماتولوجي والذي يحد من إمكانية
+
+216
+00:16:48,980 --> 00:16:56,200
+استخدامه في الإنسان الآن كونه هذا toxic للإنسان و
+
+217
+00:16:56,200 --> 00:17:02,960
+خاصة للدم تبع الإنسان ممكن نحن نقوم بحيلة أخرى
+
+218
+00:17:02,960 --> 00:17:06,380
+نقوم بها حتى في الـ antibiotics أن نقوم بأكثر من
+
+219
+00:17:06,380 --> 00:17:11,810
+antibiotic مع بعض مثلاً ولـ ZDV بإمكانها التعامل مع
+
+220
+00:17:11,810 --> 00:17:19,190
+ديدانوسين وزالسيتابين لتخلص الميزة من كل ميزة و
+
+221
+00:17:19,190 --> 00:17:20,850
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+222
+00:17:20,850 --> 00:17:24,250
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+223
+00:17:24,250 --> 00:17:27,830
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+224
+00:17:27,830 --> 00:17:28,650
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+225
+00:17:28,650 --> 00:17:32,330
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+226
+00:17:32,330 --> 00:17:37,120
+تخل 300 جرام 300 جرام 300 جرام 300 جرام 300 جرام
+
+227
+00:17:37,120 --> 00:17:45,760
+300 جرام 300 جرام 300 جرام 300 جرام 300 جرام 300
+
+228
+00:17:45,760 --> 00:17:49,480
+جرام 300 جرام 300 جرام 300 جرام 300 جرام 300 جرام
+
+229
+00:17:49,480 --> 00:17:50,220
+300 جرام 300 جرام 300 جرام 300 جرام 300 جرام 300
+
+230
+00:17:50,220 --> 00:17:51,820
+300 جرام 300 جرام 300 جرام 300 جرام 300 جرام 300
+
+231
+00:17:51,820 --> 00:17:55,240
+جرام 300
+
+232
+00:17:55,240 --> 00:18:03,550
+جرام هو مقترح للطبيعي الذي هو غير مقاوم للـ ZDV
+
+233
+00:18:05,740 --> 00:18:08,920
+يعني لأي سبب من الأسباب صار عنده reaction، صار
+
+234
+00:18:08,920 --> 00:18:12,620
+عنده ضعف، صار عنده ألم، صار عنده side effect من الـ
+
+235
+00:18:12,620 --> 00:18:18,360
+ZDV يبقى نستطيع أن نستخدم didanosine replacement or
+
+236
+00:18:18,360 --> 00:18:22,460
+whose disease has progressed أو هؤلاء الأشخاص
+
+237
+00:18:22,460 --> 00:18:28,060
+الذين أعطوا ZDV ومع ذلك المرض ما لنا مش ماله يتطور
+
+238
+00:18:28,060 --> 00:18:31,120
+ويزداد سوءاً معناه الحاجة أن الفيروس صار يشملّه
+
+239
+00:18:31,120 --> 00:18:38,210
+مقاوم للـ ZDV ميكانيزم الـ ZD-V بشكل مشابه لـ ZD-V
+
+240
+00:18:38,210 --> 00:18:44,870
+ثلاثة أخرى أدوات زلستيبين، ستابيودين ولمبيودين
+
+241
+00:18:44,870 --> 00:18:48,350
+تستخدم أيضاً في حالة مشابهة، ماذا يعني في حالة
+
+242
+00:18:48,350 --> 00:18:51,750
+مشابهة؟ التي هم... التي... التي... التي... التي...
+
+243
+00:18:51,750 --> 00:18:53,770
+التي قلنا عنهم الجثتين، الجثة الأولى أن واحد
+
+244
+00:18:53,770 --> 00:18:56,910
+intolerant لـ ZD-V أو أن الـ disease has
+
+245
+00:18:56,910 --> 00:19:03,270
+progressed في وجود الذي هو ZD-V من بعض العقاقير
+
+246
+00:19:03,270 --> 00:19:08,390
+التي يستخدموها كـ classes في الـ antiviral drugs هم
+
+247
+00:19:08,390 --> 00:19:11,830
+الـ protease inhibitors أعتقد أن شفنا مثالين عليهم
+
+248
+00:19:11,830 --> 00:19:16,610
+و non-nucleotide reverse transcriptase inhibitor
+
+249
+00:19:16,610 --> 00:19:19,510
+في كمان حاجة ما ذكرناش نحن لها الـ fusion
+
+250
+00:19:19,510 --> 00:19:23,550
+inhibitor ماذا يعني fusion inhibitor؟ أنتم تعرفون
+
+251
+00:19:23,550 --> 00:19:30,330
+أنه فاكرين الـ GP120 والـ GP41 اللي مرتبطة بمين؟ بالـ
+
+252
+00:19:30,330 --> 00:19:34,870
+receptor CD4 و الـ co receptor هدول الاثنين هو
+
+253
+00:19:34,870 --> 00:19:38,970
+المسؤولين عن بعد ذلك اللي هو الـ sequence of fusion
+
+254
+00:19:38,970 --> 00:19:42,690
+لو صار فيه أي interference هذا بيمنع مين؟ الـ fusion
+
+255
+00:19:42,690 --> 00:19:49,660
+فبسموها fusion inhibitors هل مازال الـ HIV على حاله
+
+256
+00:19:49,660 --> 00:19:55,180
+و لا فيه تطورات بتصير في الدنيا في هذا المجال؟ في
+
+257
+00:19:55,180 --> 00:20:04,400
+2007، قبل عشر سنوات، هذه المعلومات من كتاب 2010
+
+258
+00:20:04,400 --> 00:20:11,140
+-2011، ممكن تكون في تطورات أخرى وعقاقير أخرى الـ
+
+259
+00:20:11,140 --> 00:20:13,700
+FDA، الكل كان يعرفها في الـ FDA، الـ Food and Drug
+
+260
+00:20:13,700 --> 00:20:14,320
+Administration
+
+261
+00:20:20,070 --> 00:20:27,370
+وهذا العقار بعمل blocking للـ binding للـ GP121 في
+
+262
+00:20:27,370 --> 00:20:30,190
+الـ core receptor اللي هو اسمه CCR5
+
+263
+00:20:34,810 --> 00:20:40,370
+الـ GP121 مع الـ CD4 مع الـ GP41 مع الـ CCXR هذه
+
+264
+00:20:40,370 --> 00:20:45,110
+العملية إذا ما تمت الـ HRV بيسهل الـ entry فالـ
+
+265
+00:20:45,110 --> 00:20:48,890
+Marivalok بيعمل interference مع هذا الـ binding
+
+266
+00:20:48,890 --> 00:20:51,610
+وبالتالي بيمنع الفيروس من الارتباط
+
+267
+00:20:54,780 --> 00:20:59,020
+الدواء في الارتباط يعني مش ضروري تكون 100% هذا
+
+268
+00:20:59,020 --> 00:21:02,700
+واحد، اثنين احنا بنعطي الدواء لمين؟ لو واحد بده
+
+269
+00:21:02,700 --> 00:21:06,240
+يُصاب ولا مصاب؟ مصاب، معناه حاجة أنه في فيه فيه
+
+270
+00:21:06,240 --> 00:21:09,860
+فيه فيه فيه فيه في داخل الخلايا، يعني ما بنقدرش
+
+271
+00:21:09,860 --> 00:21:13,560
+برضه كمان نعمل prevention term لـ death disease
+
+272
+00:21:13,560 --> 00:21:16,700
+وعشان ما يصيرش فيه resistance البنات بقول لك أنه it
+
+273
+00:21:16,700 --> 00:21:19,580
+should be used in combination with other
+
+274
+00:21:19,580 --> 00:21:24,660
+antiretroviral drugs يعني بنخاف عليه كثير، ما بدناش
+
+275
+00:21:24,660 --> 00:21:28,320
+يا سيدي، resistant اللي هو بسرعة، برضه في 2007 الـ
+
+276
+00:21:28,320 --> 00:21:33,280
+FDA طلعت drug جديد وهذا الـ drug أول drug بيشتغل
+
+277
+00:21:33,280 --> 00:21:37,860
+على إنزيم الـ integrase طبعا فاكرين أنتم هنجود لأن
+
+278
+00:21:37,860 --> 00:21:40,520
+فينا ثلاثة enzymes فاكرين هم؟ reverse
+
+279
+00:21:40,520 --> 00:21:45,000
+transcriptase و protease و integrase الآن شوفنا
+
+280
+00:21:45,000 --> 00:21:47,580
+قبل شوية reverse transcriptase inhibitor وشوفنا
+
+281
+00:21:47,580 --> 00:21:51,520
+protease inhibitor هذا هو الأول من صنف اللي
+
+282
+00:21:51,520 --> 00:21:56,280
+هم الـ integrase أنا أعتقد أن هذا يعني ممكن يكون له
+
+283
+00:21:56,280 --> 00:22:02,340
+أثر كويس في القضاء على الـ HIV لو بالفعل كان فعال
+
+284
+00:22:02,340 --> 00:22:08,530
+بشكل جيد، ليش؟ most of cells اللي بيصير فيها
+
+285
+00:22:08,530 --> 00:22:14,050
+infection بالـ HIV في الآخر في المحصلة بتموت
+
+286
+00:22:14,790 --> 00:22:19,250
+في المحصلة بتموت فإذا الآن هذا الـ drug منع الـ
+
+287
+00:22:19,250 --> 00:22:23,290
+integration تنهار يبقى معناه يحكي أنه هيمنع الـ
+
+288
+00:22:23,290 --> 00:22:27,310
+common تبع اللي هو الـ HIV وبتالي ممكن يقضي على الـ
+
+289
+00:22:27,310 --> 00:22:32,550
+HIV لكن مش فاهمين احنا بالضبط القابلية اللي الـ HIV
+
+290
+00:22:32,550 --> 00:22:37,790
+can survive in cells وغالبا مش هيكون لوحده كافي
+
+291
+00:22:37,790 --> 00:22:44,010
+للقضاء على الـ HIV اسمه رالتي غريفير وهو الـfirst
+
+292
+00:22:44,010 --> 00:22:49,970
+drug to inhibit الـHIV encoded integrase ونفس
+
+293
+00:22:49,970 --> 00:22:55,310
+الشيء يمكن استخدام فيه المرضى اللي أولجه بقدر
+
+294
+00:22:55,310 --> 00:22:59,890
+أنتريتروفيرل لكن فشلت هذي الانتريتروفيرل في خفض الـ
+
+295
+00:22:59,890 --> 00:23:06,150
+viral load أو تحسين الـCD4 count المصطلح اللي
+
+296
+00:23:06,150 --> 00:23:10,530
+أمامكم هذا مصطلح مر علينا قبل ذلك وناقشناه بعناية
+
+297
+00:23:10,530 --> 00:23:16,350
+واسمه immune reconstitution syndrome وهذا الـ
+
+298
+00:23:16,350 --> 00:23:19,650
+immune reconstitution syndrome من ضمن القضايا اللي
+
+299
+00:23:19,650 --> 00:23:24,170
+ناقشناها سابقا في أن دور الـ immune system في تدمير
+
+300
+00:23:24,170 --> 00:23:28,090
+بعض الأعضاء في خلال الـ viral infection يعني ما كانش
+
+301
+00:23:28,090 --> 00:23:32,620
+السبب هو الفيروس مباشرة تم نرميه على الـ Immune System
+
+302
+00:23:32,620 --> 00:23:34,560
+وجودنا هذه الكلام في Hepatitis B و Hepatitis C
+
+303
+00:23:34,560 --> 00:23:39,660
+واضح جدا لنا الآن تخيل لو واحد عنده HIV وعنده
+
+304
+00:23:39,660 --> 00:23:44,880
+Hepatitis B الآن لأن الـ Immune System منخفض فلن
+
+305
+00:23:44,880 --> 00:23:50,100
+يكون هناك ضرر على مين؟ على الكبد لأن ما فيش Immune
+
+306
+00:23:50,100 --> 00:23:54,860
+System يضر بمين؟ بالكبد لو عالجنا الـ Immune System
+
+307
+00:23:54,860 --> 00:24:00,950
+... الـ HIV ورفعنا الـ CD4 count بالـ Highly Active
+
+308
+00:24:00,950 --> 00:24:04,460
+Antiretroviral Therapy اللي سميناها HART بيصحى الـ
+
+309
+00:24:04,460 --> 00:24:08,020
+immune system يقول أنت ايش بتسوي هنا على Hepatitis
+
+310
+00:24:08,020 --> 00:24:12,600
+ايش أنت بتسوي هنا ويقعد يقتل في الخلايا تبع الكبد
+
+311
+00:24:12,600 --> 00:24:16,840
+ويعمل destruction لمن؟ للـ liver لذلك هم بيسموه
+
+312
+00:24:16,840 --> 00:24:20,700
+immune reconstitution syndrome صحى الجهاز المناعي
+
+313
+00:24:20,700 --> 00:24:24,800
+تحسن جهاز المناعة فبدأ يشتغل على اللي هو الملفات
+
+314
+00:24:24,800 --> 00:24:27,800
+اللي قدامه اللي موجودة ومن ضمنها تدمير بعض
+
+315
+00:24:27,800 --> 00:24:33,810
+الأنسجة المصابة بأي فيروس طب ما هيش نعمل؟ وإن إذا
+
+316
+00:24:33,810 --> 00:24:39,570
+كان عندنا مريض HIV لابد متى كان الأمر متاحا... متى
+
+317
+00:24:39,570 --> 00:24:44,870
+كان الأمر متاحا لابد لنا من البحث عن الأمراض
+
+318
+00:24:44,870 --> 00:24:51,070
+الأخرى وعلاجها قبل مين؟ قبل علاج اللي هو الـ HIV
+
+319
+00:24:51,070 --> 00:24:55,290
+خشية أنه زي ما حكينا يتحسن الـ immune system عنده
+
+320
+00:24:55,290 --> 00:25:03,810
+يدور بهذا الاسم اللي بس الـ diagnosis للـ HIV طبعا من
+
+321
+00:25:03,810 --> 00:25:08,210
+أول ما ظهر هذا المرض بدأ موضوع الـ screening يقلق
+
+322
+00:25:08,210 --> 00:25:15,570
+أو يقرق العاملين في القطاع الوبائي وفي CDC وفي
+
+323
+00:25:15,570 --> 00:25:18,990
+طوروا فحص سريع جدا اسمه ELISA اللي هو الـ enzyme
+
+324
+00:25:18,990 --> 00:25:24,790
+linked immunosorbent assay و الفحص كان الحقيقة
+
+325
+00:25:24,790 --> 00:25:30,030
+يعني very sensitive بمعنى أنه الـ negative يكون
+
+326
+00:25:30,030 --> 00:25:35,350
+عندها negative حقيقي بينما مش specific وهذا هي من
+
+327
+00:25:35,350 --> 00:25:38,970
+معالم سمات الـ screening test بتكون sensitive و
+
+328
+00:25:38,970 --> 00:25:40,290
+بتكونش specific
+
+329
+00:25:44,130 --> 00:25:47,890
+يعني بتستثني الـ negative الحقيقي لكن الـ
+
+330
+00:25:47,890 --> 00:25:51,470
+positive لابد أن نعمل له confirmatory test
+
+331
+00:25:51,470 --> 00:25:58,110
+وبالتالي الـ confirmatory test المستخدمة للـ HIV هي
+
+332
+00:25:58,110 --> 00:26:02,470
+نفس الـ confirmatory test اللي بنستخدمها للـ retro
+
+333
+00:26:02,470 --> 00:26:09,070
+virus الـ HTLV-1 وHTLV-2 مين بتذكرها؟ فصفحات ثانية
+
+334
+00:26:09,070 --> 00:26:11,570
+اللي هي
+
+335
+00:26:14,670 --> 00:26:21,490
+برضه مش عارفينها؟ وسترن بلوت تكنيك وسترن بلوت تكنيك
+
+336
+00:26:21,490 --> 00:26:25,330
+طبعا هذه الصورة اللي أمامنا هي اللي هو الـ ELISA
+
+337
+00:26:25,330 --> 00:26:28,930
+for HIV طبعا اللون الأصفر هذا بيعطينا أنه reactive
+
+338
+00:26:28,930 --> 00:26:32,910
+وفي طبعا الآن فينا cartridge شايفينها الـ HIV
+
+339
+00:26:32,910 --> 00:26:40,310
+موجودة بشكل تجاري وسهل وقطرة الدم ثم إذا اتضح
+
+340
+00:26:40,310 --> 00:26:43,590
+الخطين هدول في بوستر إذا خط واحد في الـ control
+
+341
+00:26:43,590 --> 00:26:47,070
+بيكون الفحص negative طبعا الـ Negative هذا لا
+
+342
+00:26:47,070 --> 00:26:50,950
+يستدعي تجارب أكثر، لكن الـ Positive هذا يستدعي
+
+343
+00:26:50,950 --> 00:26:56,630
+تجارب تجارب أكثر،
+
+344
+00:26:56,630 --> 00:26:58,630
+لكن الـ Positive هذا يستدعي تجارب تجارب أكثر، لكن
+
+345
+00:26:58,630 --> 00:26:58,730
+الـ Positive هذا يستدعي تجارب تجارب أكثر، لكن الـ
+
+346
+00:26:58,730 --> 00:27:00,070
+Positive هذا يستدعي تجارب تجارب أكثر، لكن الـ
+
+347
+00:27:00,070 --> 00:27:00,390
+Positive هذا يستدعي تجارب تجارب أكثر، لكن الـ
+
+348
+00:27:00,390 --> 00:27:00,970
+Positive هذا يستدعي تجارب تجارب أكثر، لكن الـ
+
+349
+00:27:00,970 --> 00:27:01,790
+Positive هذا يستدعي تجارب تجارب أكثر ما بكشفش فيه
+
+350
+00:27:01,790 --> 00:27:05,990
+عن مين؟ عن الـ antibody واللي بكشف عن الـ antigen باستخدام
+
+351
+00:27:05,990 --> 00:27:09,990
+أجسام اللي هو primary و secondary antibodies واحد
+
+352
+00:27:09,990 --> 00:27:14,030
+منهم أنزين برضه conjugated والعملية هي فأنا
+
+353
+00:27:14,030 --> 00:27:17,490
+هحط لكم هنا link اللي بدي حابب يشوف اللي هو الفيديو
+
+354
+00:27:17,490 --> 00:27:21,110
+كيف بيشتغل من ألف إلى ياء في الـ western blot
+
+355
+00:27:21,110 --> 00:27:24,790
+technique طبعا المهم أنكم تطلعوا على التكنيك حتى
+
+356
+00:27:24,790 --> 00:27:27,710
+لو ما اشتغلتوش في المعمل يعني مجرد رؤيتكم أقول لكم
+
+357
+00:27:27,710 --> 00:27:31,030
+كيف ناس بتشتغلوا من ألف إلى ياء هذا بيعطيكم
+
+358
+00:27:31,030 --> 00:27:36,250
+فكرة جيدة عن هذا الفحص طيب
+
+359
+00:27:36,250 --> 00:27:39,330
+هذا بالنسبة للـ diagnostic test اللي هم جونا
+
+360
+00:27:39,330 --> 00:27:43,450
+screening ومين؟ وconfirmatory test جونا الـ ELISA
+
+361
+00:27:43,450 --> 00:27:48,370
+بالإضافة إلى الـ western blot الـ prognostic test
+
+362
+00:27:55,420 --> 00:28:04,880
+في كام فحص اسمه HIV P24 يستخدموه كـ quantitative
+
+363
+00:28:04,880 --> 00:28:11,640
+measure يجيسوا فيه الـ HIV وكان لفترة معينة هو يعني
+
+364
+00:28:11,640 --> 00:28:18,900
+المعتمد لكن مع مرور الوقت بدأت فكرة أن ندور على الـ CD4
+
+365
+00:28:18,900 --> 00:28:25,740
+count لجوا أن الـ CD4 count أدق بكثير من الـ P24
+
+366
+00:28:25,740 --> 00:28:30,760
+وبالتالي أصبح الـ CD4 count أو ما يسمى بالـ serial
+
+367
+00:28:30,760 --> 00:28:35,620
+CD4 count ليش serial؟ لأنه متكرر يعني مش مرة واحدة
+
+368
+00:28:35,620 --> 00:28:44,560
+وإنما بشكل مستمر فجرى الاتفاق على أن الـ P24 تم يعني
+
+369
+00:28:44,560 --> 00:28:50,820
+أيه؟ باستبعاده واستبعاده من مين؟ serial CD4 count
+
+370
+00:28:50,820 --> 00:28:54,520
+طب جالهم هذا الـ CD4 count معبر عن مين؟ عن الـ immune
+
+371
+00:28:54,520 --> 00:28:57,850
+system طب بدنا حاجة ثانية أنها تعبر عن الفيروس
+
+372
+00:28:57,850 --> 00:29:03,270
+نفسه فجعلوا يتكلموا عن الـViral Load أو الـViral RNA
+
+373
+00:29:03,270 --> 00:29:09,250
+الـHIV Viral RNA ويسمّى هذه الحاجة الـHIV Viral
+
+374
+00:29:09,250 --> 00:29:12,890
+Load ويتم الكشف عنه بالـ RT أو Reverse
+
+375
+00:29:12,890 --> 00:29:18,050
+Transcriptase PCR إذا 
+
+376
+00:29:18,050 --> 00:29:21,250
+فاندي two parameters اللي هم مين؟ اللي هم الـCD4
+
+377
+00:29:21,250 --> 00:29:24,470
+count والتانية الـHIV Viral Load
+
+378
+00:29:27,500 --> 00:29:34,840
+طلع على اللوحة دي، اللوحة اللي راسمينها مكونة من
+
+379
+00:29:34,840 --> 00:29:38,060
+لونين رئيسيين، اللون الأزرق شايفينه؟ واللون الثاني
+
+380
+00:29:38,060 --> 00:29:43,080
+عنها أحمر، الأحمر هو الـHIV RNA copies وكلمة HIV 
+
+381
+00:29:43,080 --> 00:29:46,960
+RNA copies معناها الآخر لمين؟ لـViral Loads، وعالجهة
+
+382
+00:29:46,960 --> 00:29:52,180
+الأخرى CD4 T lymphocyte count cells per cubic
+
+383
+00:29:52,180 --> 00:29:57,220
+millimeter لما بدأنا في الـ infection أو قبل الـ
+
+384
+00:29:57,220 --> 00:30:01,780
+infection كان في اندي الرقم تبع الـ CD4 جداش حوالي
+
+385
+00:30:01,780 --> 00:30:07,660
+1200 خلية per cubic millimeter والفيروس جداش
+
+386
+00:30:10,110 --> 00:30:15,750
+بين ايه؟ بينها ماله؟ Zero مافي عندي viruses يبقى
+
+387
+00:30:15,750 --> 00:30:19,510
+هذا كان at maximum وهذا شماله minimum مافيش Zero
+
+388
+00:30:19,510 --> 00:30:22,830
+يعني لو قاعدت أنا أعمل علاقة بقول علاقة ايش بينهم؟
+
+389
+00:30:22,830 --> 00:30:27,070
+أقولها علاقة عكسية، لما كان هذا مرتفع هذا كان منخفض
+
+390
+00:30:27,070 --> 00:30:32,910
+جدا، اطلعوا على الـ CD4 بالظبط كيف ماشية وعلى جبالها
+
+391
+00:30:32,910 --> 00:30:39,700
+شماله، هذه اللي بيسموها الـ perfect inverse relation
+
+392
+00:30:39,700 --> 00:30:45,720
+العلاقة العكسية التامة، إذا ارتفع هذا لإنه أصلاً سبب
+
+393
+00:30:45,720 --> 00:30:52,920
+انخفاض الـ CD4 هو ارتفاع عدد الـ multiplication اللي
+
+394
+00:30:52,920 --> 00:30:59,080
+أدى لقتل هذه الخلايا، طبعًا بتلاحظوا، ما بعرفش نمشي مع
+
+395
+00:30:59,080 --> 00:31:02,720
+بعض، عشان مهم..مهم..مهم الـ الـ الخطوة دي
+
+396
+00:31:02,720 --> 00:31:07,960
+الـ primary infection weeks تنخفض، بعدين تعود ترتفع
+
+397
+00:31:07,960 --> 00:31:12,200
+إلى مستوى معين، وبعدين.. شوفتوا القطر هذا في 
+
+398
+00:31:12,200 --> 00:31:16,180
+الكلمة، ما معنى القطر هذا؟ إنه بدأنا نتكلم مش
+
+399
+00:31:16,180 --> 00:31:19,880
+إسرابية، نتكلم عن ايه؟ شهور أو سنوات، يعني القطر
+
+400
+00:31:19,880 --> 00:31:25,870
+هذا تغيرنا من weeks إلى مين؟ إلى شهور، هذا المرحلة
+
+401
+00:31:25,870 --> 00:31:28,430
+الـ متعرفة عليها في الـ curves لما أنا ما قلتش حطينا
+
+402
+00:31:28,430 --> 00:31:32,350
+دولة، ما نحكي إن في cut في قطر زمني بين هذه الأشياء
+
+403
+00:31:32,350 --> 00:31:40,610
+طيب ما زلنا لو أخذنا خط أفقي 700، 500، 400
+
+404
+00:31:40,610 --> 00:31:46,630
+متى وصلنا، طلع لجداش، شوف المقطة هذه العمودي من
+
+405
+00:31:46,630 --> 00:31:52,550
+جانب هنا، لما وصلنا هنا لو أخذنا خط، أخذنا، وصلنا مين؟
+
+406
+00:31:52,550 --> 00:31:57,890
+200.. الآن هذا الـ windows أو الـ window ها دي اسمها
+
+407
+00:31:57,890 --> 00:32:00,710
+clinical latency متى بيبقى اللي تنسي شعار اللي
+
+408
+00:32:00,710 --> 00:32:04,590
+تنسي؟ common سريري، يعني لا يظهر على المريض أي
+
+409
+00:32:04,590 --> 00:32:09,110
+إشارة، متى بيبقى تظهر عليه الإشارات؟ لما نزل مسترة
+
+410
+00:32:09,960 --> 00:32:15,200
+الـ CD4 count إلى أقل من 200 بدأت تظهر عليه
+
+411
+00:32:15,200 --> 00:32:19,520
+repeated infection من very simple microorganisms
+
+412
+00:32:19,520 --> 00:32:22,340
+زي الـ Candida، زي الكابوساركومة، زي الـ
+
+413
+00:32:22,340 --> 00:32:24,780
+Pneumocystis Girovici اللي قلنا لك هو عبارة عن
+
+414
+00:32:24,780 --> 00:32:28,480
+فنجس أو ييست، كان يعتقد أنه في السابق أنه برازيل،
+
+415
+00:32:28,480 --> 00:32:33,800
+بالمقابل، كل ما ذكرناه من انخفاض كان مقابله شيء منه
+
+416
+00:32:33,800 --> 00:32:37,480
+صعود، ارتفاع في مين؟ في الـ viral load، كمان مرة الـ
+
+417
+00:32:37,480 --> 00:32:42,380
+viral load أخذ peak معينة تمام؟ وبعدين استقر، والـ
+
+418
+00:32:42,380 --> 00:32:47,040
+تفع ارتفاع بطيء جداً، هذا الـ normal course، بطيء
+
+419
+00:32:47,040 --> 00:32:50,220
+جداً، لاحظوا في السنوات الأخيرة اللي هي جاية من
+
+420
+00:32:50,220 --> 00:32:58,730
+مين؟ واللي أقل من 200 الـ viral load ارتفع كبير وهنا
+
+421
+00:32:58,730 --> 00:33:03,730
+قد تحدث الوفاة لما يصل الرقم، ترجمتها فوق العشرة أو
+
+422
+00:33:03,730 --> 00:33:07,150
+الستة أو بين عشرة أو ستة أو بين عشرة أو ستة أبعاء ملي
+
+423
+00:33:07,150 --> 00:33:12,300
+لتر، هناك علاقة وطيدة نستطيع من خلالها أن نعمل
+
+424
+00:33:12,300 --> 00:33:18,180
+follow-up نشوف هل في تقدم أو في سوق للحالة يعني
+
+425
+00:33:18,180 --> 00:33:21,840
+progression لـ الـ disease ولا regression لـ الـ
+
+426
+00:33:21,840 --> 00:33:25,980
+disease من خلال الـ two parameters اللي هم من CD4 والـ
+
+427
+00:33:25,980 --> 00:33:29,380
+viral load، والـ viral load معبر عن مين؟ قلنا عن
+
+428
+00:33:29,380 --> 00:33:34,730
+الـ HIV RNA copies، الـ HIV RNA copies معبر أيضًا
+
+429
+00:33:34,730 --> 00:33:39,030
+على العدد اللي هو الفيروسات اللي مولودة في الإنسان
+
+430
+00:33:39,030 --> 00:33:45,370
+طيب الـ prevention الـ risk، طلع الجملة الأولى
+
+431
+00:33:45,370 --> 00:33:49,590
+والجملة الثانية عشان بدنا نكون دائمًا نفهم إن
+
+432
+00:33:49,590 --> 00:33:53,970
+الأجانب ما بيحبوا يحكوا الحقيقة في هذا الموضوع، الـ
+
+433
+00:33:53,970 --> 00:33:57,090
+risk of contracting HIV increases with the number
+
+434
+00:33:57,090 --> 00:34:01,780
+of sexual partners، كل ما زاد عدد الشركاء الجنسيين
+
+435
+00:34:01,780 --> 00:34:07,520
+كل ما زاد احتماليه اللي هو اخذ أو اقتصاد الـ HIV
+
+436
+00:34:07,520 --> 00:34:13,180
+طبعًا ايش التعبير المخفف المستخدم من قبلهم عشان
+
+437
+00:34:13,180 --> 00:34:17,040
+ينصحوا a change in the lifestyle، ايش يعني change
+
+438
+00:34:17,040 --> 00:34:20,060
+in the lifestyle؟ تغيير في أسلوب الحياة، أيش تغيير
+
+439
+00:34:20,060 --> 00:34:24,000
+في أسلوب الحياة؟ يعني التزم بالتعليم الدينية، سواء
+
+440
+00:34:24,000 --> 00:34:27,760
+كانت الإسلامية ولا المسيحية ولا اليهودية، بتحرم
+
+441
+00:34:27,760 --> 00:34:31,120
+الزنا، مظبوط ولا مظبوط؟ وبالتالي، لكن لا يستطيعوا
+
+442
+00:34:31,120 --> 00:34:35,340
+يقولوا هذا الكلام، لأن هم مش معنيين بإنهم يوقفوا
+
+443
+00:34:35,340 --> 00:34:40,730
+هذا المفهوم، التغيير في طريقة الحياة سيقوم بالتقليد
+
+444
+00:34:40,730 --> 00:34:43,950
+أو تقليد، رغم هذا التغيير الهيوغو من خلال
+
+445
+00:34:43,950 --> 00:34:48,450
+تنسيق دماغ يتم إيقافه، لماذا؟ لأنه الآن مافيش أي
+
+446
+00:34:48,450 --> 00:34:52,210
+دونار إلا بيفحصه، حتى الآن في غزة من سنة ألف
+
+447
+00:34:52,210 --> 00:34:56,090
+وتسعمائة وتسعين أو واحدة وتسعين، مش متأكد بالضبط
+
+448
+00:34:56,090 --> 00:35:01,760
+التاريخ، هذا العام بتدخل فيه خدمة اللي هو الـ HIV
+
+449
+00:35:01,760 --> 00:35:07,620
+testing لكل blood bag تمام؟ وبالتالي جثة إنه ينتقل
+
+450
+00:35:07,620 --> 00:35:11,920
+عن طريق blood bag هذا أو blood transfusion هذا أمر
+
+451
+00:35:11,920 --> 00:35:15,820
+غير وارد، لكن ما زال الـ risk اللي بتعاطف منه إنها
+
+452
+00:35:15,820 --> 00:35:22,780
+المخدرة AZA أو AZT had been shown to be effective
+
+453
+00:35:22,780 --> 00:35:28,460
+in preventing transmission of HIV from mother to
+
+454
+00:35:28,460 --> 00:35:32,340
+the fetus، فكدا ما كنا نجيب شوية أفريقيا وأوروبا
+
+455
+00:35:32,340 --> 00:35:36,440
+لما بيناكوا 15 إلى 50 بالمية وبيناكوا قد
+
+456
+00:35:36,440 --> 00:35:41,240
+لا تكون الفروقات بنسبة لهتين نسبتين بسبب
+
+457
+00:35:41,240 --> 00:35:44,180
+الجغرافيا، إنما بسبب التطور الطبي وسبب الـ medical
+
+458
+00:35:44,180 --> 00:35:48,690
+treatment، هذا أحد الدخلات اللي قللت من الإصابة
+
+459
+00:35:48,690 --> 00:35:51,490
+الأطفال، وطالع عايشة النتيجة كانت الـ incidence of
+
+460
+00:35:51,490 --> 00:35:54,950
+HIV infection in the baby was reduced by two
+
+461
+00:35:54,950 --> 00:36:00,110
+thirds، يعني من كل تلاتة كان المفروض إنه مصاب صار
+
+462
+00:36:00,110 --> 00:36:02,610
+واحد اللي فقط ايه أو الاحتمالية إنه ينصاب إنه
+
+463
+00:36:02,610 --> 00:36:07,560
+ينصاب واحد فقط، The management of healthcare workers
+
+464
+00:36:07,560 --> 00:36:11,880
+وهذا نقطة لكم أنتو اللي بتعملوا في مجال التحديث
+
+465
+00:36:11,880 --> 00:36:16,440
+الطبي، وأكثر ناس بنغزوا قبر إذا كانوا ما اتبعوش
+
+466
+00:36:16,440 --> 00:36:20,740
+تعليمات إلا أنا بنات السياسة العامة عدم إرجاع الـ
+
+467
+00:36:20,740 --> 00:36:28,320
+needle إلى الـ wild cap تبعته، ليش؟ ليش احنا بنغلط؟
+
+468
+00:36:28,870 --> 00:36:34,370
+أول حاجة الإرهاق اللي ممكن يصيب العاملين في المجال
+
+469
+00:36:34,370 --> 00:36:40,930
+الصحي كبير، ضعف النظر اللي بيصاحب التقدم في السن
+
+470
+00:36:40,930 --> 00:36:42,070
+تمام؟
+
+471
+00:36:44,950 --> 00:36:49,870
+الإنسان بيكون تعبان فتركيزه بيكون أقل، ضغط العمل
+
+472
+00:36:49,870 --> 00:36:54,070
+بعض الأحيان برضه بيأثر على هذا العمل، لذلك القاعدة
+
+473
+00:36:54,070 --> 00:36:57,290
+العامة بتقول إنه don't recap the needle, dispose
+
+474
+00:36:57,290 --> 00:37:05,150
+the needle، فيه needle box خاص فيها العمل، لكن على
+
+475
+00:37:05,150 --> 00:37:07,990
+الرغم من ذلك بيقولوا إنه على الرغم من كل
+
+476
+00:37:07,990 --> 00:37:16,880
+الاحتياطات، Incidents occur، يعني الحالات تحدث
+
+477
+00:37:16,880 --> 00:37:24,340
+فبيقول إنه يا دلترا إذا صار فيه needle injury لوحد
+
+478
+00:37:24,340 --> 00:37:27,900
+من العاملين في المجال الصحي ايش نعمله؟ بقول هذا
+
+479
+00:37:27,900 --> 00:37:32,880
+قضية قضية قضية جدالية، ليه جدالية؟ بقول أبي أعطيه
+
+480
+00:37:32,880 --> 00:37:36,840
+مثلاً prophylaxis antiviral prophylaxis زي الـ AZT
+
+481
+00:37:38,530 --> 00:37:41,710
+طبعًا هنا لا جداش نعطيه، نعطيه ليوم واحد ولا نعطيه
+
+482
+00:37:41,710 --> 00:37:45,510
+لأسبوع ولا نعطيه لشهر، مش جادين نحدد protocol
+
+483
+00:37:45,510 --> 00:37:51,810
+للأشخاص الذين اتعرضوا لدماء مصابة بالـ HIV
+
+484
+00:37:51,810 --> 00:37:58,890
+الفاكسينز هي بجثة طويلة طويلة جداً، لحقيقة وكل سنة
+
+485
+00:37:59,980 --> 00:38:03,460
+بنقرع في الأخبار إنه هناك زي ما احنا الآن كاتبين
+
+486
+00:38:03,460 --> 00:38:07,360
+هنا بالظبط، clinical trials for several vaccines
+
+487
+00:38:07,360 --> 00:38:10,800
+are in progress، يعني وكلمة clinical trial يا بنات
+
+488
+00:38:10,800 --> 00:38:16,540
+هي مرحلة متقدمة جداً للفحص
+
+489
+00:38:16,540 --> 00:38:18,920
+تبع الـ vaccine، يعني الـ vaccine بيكون مرة ومراحل
+
+490
+00:38:18,920 --> 00:38:24,100
+كتيرة آخرها هتكون مين؟ الـ clinical trial، تقريباً كل
+
+491
+00:38:24,100 --> 00:38:27,500
+سنة بيطلع واحد أو اثنين في الأخبار إنه another
+
+492
+00:38:27,500 --> 00:38:31,470
+clinical trial، والسنة اللي بعدها ما بنسمع عنهم
+
+493
+00:38:31,470 --> 00:38:35,050
+أخبار، تبارك على إنهم ايه؟ إنهم إنهم فشلوا إنهم
+
+494
+00:38:35,050 --> 00:38:36,870
+يعني يعطوا النسبة
+
+495
+00:38:36,870 --> 00:38:57,670
+الالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالال
+
+496
+00:38:58,250 --> 00:39:02,730
+أحد الأسباب اللي بتخلينا نفشل في إنتاج اللي هو هذا
+
+497
+00:39:02,730 --> 00:39:05,890
+الفاكسين، والمرة الجاية إن شاء الله بنكمل
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LIgItABBP8U_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LIgItABBP8U_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b6442febce1955d0d9f0f070aa0264320b057eee
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LIgItABBP8U_postprocess.srt
@@ -0,0 +1,1988 @@
+1
+00:00:21,360 --> 00:00:24,560
+طيب بسم الله الرحمن الرحيم احنا المحاضرة الماضية
+
+2
+00:00:24,560 --> 00:00:29,940
+بدأنا بالحديث عن فيروس مهم جدا قلنا اللي هو فيروس
+
+3
+00:00:29,940 --> 00:00:33,260
+الـHIV وذكرنا ان هذا الفيروس بنتمي لعيط ال
+
+4
+00:00:33,260 --> 00:00:37,040
+retroviruses اللي هي مكونة من ثلاث sub families
+
+5
+00:00:37,040 --> 00:00:42,580
+واحدة منهم ال Lentiviruses و Lentiviruses هي اللي
+
+6
+00:00:42,580 --> 00:00:47,840
+بنتمي لقولنا الـHIVوتحدثنا عن صنفين HIV-1 و HIV-2
+
+7
+00:00:47,840 --> 00:00:51,980
+وميزنا بينهم في بعض الصفات كلمنا برضه بعض التراكيب
+
+8
+00:00:51,980 --> 00:00:56,140
+المهم جدا في ال HIV مثل ال structural genes زي ال
+
+9
+00:00:56,140 --> 00:00:59,820
+pool و ال gag و ال inf واتكلمنا عن بعض اللي هم ال
+
+10
+00:00:59,820 --> 00:01:03,260
+regulatory genes و ال non essential genes وشوفنا
+
+11
+00:01:03,260 --> 00:01:06,140
+ال functions تبعت كل واحد من هذه الجينات على الأقل
+
+12
+00:01:06,810 --> 00:01:10,050
+و بعدين انتقلنا الى ال diseases associated with
+
+13
+00:01:10,050 --> 00:01:14,270
+HIV و جسمناها على ال lungs و ال .. ال .. الدم و ال
+
+14
+00:01:14,270 --> 00:01:17,670
+skin و ال .. يعني ال gastrointestinal فصلة تقريبا
+
+15
+00:01:17,670 --> 00:01:20,590
+تفصيل فيها كبيرة، اللي هان هتكلم .. هنكمل ان شاء
+
+16
+00:01:20,590 --> 00:01:25,470
+الله و نشوف ال path genesis تبع ال HIV من ال
+
+17
+00:01:25,470 --> 00:01:27,010
+characteristics انه بيعمل infection الى ال
+
+18
+00:01:27,010 --> 00:01:31,910
+lymphocyte و ال macrofibersهذا الأو هذه الخاصية
+
+19
+00:01:31,910 --> 00:01:36,830
+تجعل من هذا الفيروس قاتل للرأس للرأس من؟ الرأس ال
+
+20
+00:01:36,830 --> 00:01:41,690
+immune system المتمثل في ال CD4 cells وكمان شوية
+
+21
+00:01:41,690 --> 00:01:46,990
+هنشوف احنا ال course على ال HIVعندما بيبدأ ال
+
+22
+00:01:46,990 --> 00:01:52,430
+disease بيبدأ silent ساكن وبممكن يستمر لسنوات ساكن
+
+23
+00:01:52,430 --> 00:01:58,710
+متى بتبدأ الأعراض عندما ينقفض عدد ال CD4 في الدم
+
+24
+00:01:58,710 --> 00:02:05,390
+تمام إلى مستوى معين وهو 200 خلية per milliliter
+
+25
+00:02:05,390 --> 00:02:08,110
+بيبدأ الأعراض تبع ال HIV تظهر
+
+26
+00:02:16,090 --> 00:02:20,290
+هذا يؤدي إلى inactivation of CD4 هيلبارتيس سيل، طب
+
+27
+00:02:20,290 --> 00:02:22,870
+لما نعمل inactivation لهيلبارتيس سيل، مجرد حاجة
+
+28
+00:02:22,870 --> 00:02:27,990
+انه جزء كبير من ال activator immune cells بتروح
+
+29
+00:02:27,990 --> 00:02:31,430
+وبالتالي بالفعل بصرفي ان عن خفاض فيما يسمى بال
+
+30
+00:02:31,430 --> 00:02:34,410
+delay type hypersensitivity و ال delay type
+
+31
+00:02:34,410 --> 00:02:39,050
+hypersensitivity هي cell mediated immunity لكثير
+
+32
+00:02:39,050 --> 00:02:41,850
+من ال intracellular pathogen زي البكتيريا و
+
+33
+00:02:41,850 --> 00:02:46,670
+الفيروسلكمان الفيروس اللى مقدر على نعمل تغيير في
+
+34
+00:02:46,670 --> 00:02:49,070
+ال .. نعمل Antionic drift فاكريني ال drift و
+
+35
+00:02:49,070 --> 00:02:53,370
+shift؟ ال drift تغيير طفيف .. تغيير طفيف في اللى
+
+36
+00:02:53,370 --> 00:02:57,190
+هو ال glycoprotein 120 اللى هو المسؤول عن مين عن
+
+37
+00:02:57,190 --> 00:03:01,430
+الارتباط هذا التغييركافي إنه مايتعرفش على الـ
+
+38
+00:03:01,430 --> 00:03:05,990
+Antibody اللي اتكوّن بالأول، لكن غير كافي إنه يمنع
+
+39
+00:03:05,990 --> 00:03:10,150
+إرتباطه مين بالـ CD4، يعني ما اتغيرش بشكل
+
+40
+00:03:10,150 --> 00:03:15,290
+دراماتيكي، اتغير بشكل طفيف، خدع الـ Antibody، لكن
+
+41
+00:03:15,290 --> 00:03:19,750
+ما زال قادر على إرتباطنا مين؟ مع الـ CD4في كمان
+
+42
+00:03:19,750 --> 00:03:22,810
+شغل تاني في الجسم نفسه في الجسم الإنسان بيعمل
+
+43
+00:03:22,810 --> 00:03:26,570
+حاسمة glycosylation أو heavy glycosylation لل
+
+44
+00:03:26,570 --> 00:03:30,910
+GP120 اللي هو ال .. ال .. ال .. ال receptor اللي
+
+45
+00:03:30,910 --> 00:03:33,610
+موجه على ال HIV، إيش يعني heavy glycosylation؟
+
+46
+00:03:33,610 --> 00:03:37,710
+يعني بيعمله masking، إيش يعني masking؟ يعني زي لما
+
+47
+00:03:37,710 --> 00:03:42,370
+أحنا بنحط الجلم و بنحطله غطاي، هو حط غطا لمين؟ لل
+
+48
+00:03:42,370 --> 00:03:47,810
+GP120هذا الغطش بيعمل بيمنع برضه ال antibodies اللي
+
+49
+00:03:47,810 --> 00:03:53,610
+اتكوّنت لهذا specifically لهذاالـGlycoprotein إنه
+
+50
+00:03:53,610 --> 00:03:59,090
+يرتبط فيه، إذن الـHIV عنده طرق لخداع جهاز المناعة
+
+51
+00:03:59,090 --> 00:04:05,850
+بشكل قوي جدا من خلال أولا الارتباط وعصابة كل من
+
+52
+00:04:05,850 --> 00:04:09,910
+الـCD4 والماكروفاج، رقم اتنين inactivation of CD4،
+
+53
+00:04:09,910 --> 00:04:15,550
+رقم تلاتة اللي هو الـantigenic drift للـGP120
+
+54
+00:04:15,550 --> 00:04:18,430
+بالإضافة إلى الـheavy glycosylation أو ال masking
+
+55
+00:04:18,430 --> 00:04:20,390
+للـGP120
+
+56
+00:04:22,370 --> 00:04:27,910
+طبعا ال human herpes virus type 8 درسناها في ال
+
+57
+00:04:27,910 --> 00:04:30,410
+DNA virus اللي اتكلمنا عنه ال herpes viruses و
+
+58
+00:04:30,410 --> 00:04:34,130
+اتكلمنا عن الكابوسي ساركومة و الكابوسي ساركومة
+
+59
+00:04:34,130 --> 00:04:37,830
+واحدثات من اهم ال indicators ان هذا الإنسان قد
+
+60
+00:04:37,830 --> 00:04:44,140
+يكون مصاب بمرض ال AIDS او ال HIVالـ AIDS
+
+61
+00:04:44,140 --> 00:04:49,380
+Epidemiology بينجسمها لثلاث أقسام طرق الانتقال إما
+
+62
+00:04:49,380 --> 00:04:54,400
+عن طريق ال blood and blood products أو عن طريق ال
+
+63
+00:04:54,400 --> 00:04:57,900
+vertical transmission أو رقم واحد اللي هي ال
+
+64
+00:04:57,900 --> 00:05:01,600
+sexual transmission والحقيقة إن هم مرتبين تقريبا
+
+65
+00:05:01,600 --> 00:05:06,360
+بنفس اللي هو الأهمية ال sexual transmission اللي
+
+66
+00:05:06,360 --> 00:05:10,400
+لجوه إنه في الذكور المخنثين اللي هم اللي بيسموهم
+
+67
+00:05:10,400 --> 00:05:11,160
+homosexual
+
+68
+00:05:13,430 --> 00:05:21,390
+هما بشكله أكبر فئة تعرضة للإصابة بالـ HIV في
+
+69
+00:05:21,390 --> 00:05:24,650
+الولايات المتحدة وأوروبا لكن في الدول النامية
+
+70
+00:05:24,650 --> 00:05:29,670
+الرجال العاديين اللي هو الـ heterosexual منهم أكثر
+
+71
+00:05:29,670 --> 00:05:33,770
+فئة يصابوا إذا بدنا نتفق على أن الـ sexual
+
+72
+00:05:33,770 --> 00:05:38,170
+transmission هو أداة رئيسية لانتقال الـ HIV
+
+73
+00:05:40,740 --> 00:05:42,860
+الادارة الثانية اللي هي ال blood and blood
+
+74
+00:05:42,860 --> 00:05:46,580
+products وكلمة blood products يعني بدل ما اعطي
+
+75
+00:05:46,580 --> 00:05:48,920
+whole blood باعطي مثلا ال platelet concentrate
+
+76
+00:05:48,920 --> 00:05:52,040
+باعطي factors معينة coordination factors لبعض
+
+77
+00:05:52,040 --> 00:05:55,480
+المرضى هذا بيسموها blood product باعطي بلازمة لحال
+
+78
+00:05:56,700 --> 00:06:00,680
+لكن في نقطة مهمة جدا قبل ما نتكلم عن ال blood bags
+
+79
+00:06:00,680 --> 00:06:03,840
+و ال blood products نتكلم عن ال IV drug users اللي
+
+80
+00:06:03,840 --> 00:06:07,180
+هم مدمني المخدرات اللي بيحكموا أنفسهم جننا بيه
+
+81
+00:06:07,180 --> 00:06:13,320
+بمخدرات و بتشاركوا بالقبر طبعا هدولة لما نقول drug
+
+82
+00:06:13,320 --> 00:06:18,010
+abusers هذا مش دمهم الوحيد خدوا بالكوا كالخمرالخمر
+
+83
+00:06:18,010 --> 00:06:21,350
+طوله بالعقل فإذا دعا بالعقل يرتكب الإنسان كل
+
+84
+00:06:21,350 --> 00:06:26,190
+الفواحش ومن ضمنها الزنا والليواط وغيره وبالتالي
+
+85
+00:06:26,190 --> 00:06:31,630
+هؤلاء الناس لديهم برضه فرصة عالية لاجتساب هذا
+
+86
+00:06:31,630 --> 00:06:35,050
+المرض إما من خلال مشاركة الإبر أو من خلال الأفعال
+
+87
+00:06:35,050 --> 00:06:42,620
+الأخرى تيقومون بها في الفئاتاللي ظهر انها high
+
+88
+00:06:42,620 --> 00:06:45,880
+risk group الناس اللي عندهم Hemophilia واللي عندهم
+
+89
+00:06:45,880 --> 00:06:51,020
+Hemophilia دايما بيعطوا factor تمانية وهو يعني
+
+90
+00:06:51,020 --> 00:06:55,180
+يفصل من ال blood bags ويعطيه خصيصا لهؤلاء المرضى
+
+91
+00:06:55,180 --> 00:06:59,280
+وبالتالي هدول الناس كان عرضة للإصابة بال HIV قبل
+
+92
+00:06:59,280 --> 00:07:02,960
+ما يدخل عملية الفحوصات لل HIV في ال blood bag
+
+93
+00:07:02,960 --> 00:07:08,300
+تلاتة Vertical Transmissionطلعوا ليها الجملة اللي
+
+94
+00:07:08,300 --> 00:07:13,340
+في سطر اتنين وإنها varies from around 15% in
+
+95
+00:07:13,340 --> 00:07:18,760
+western Europe to up to 50% in Africa الآن البعض
+
+96
+00:07:18,760 --> 00:07:22,360
+على طول بينظر لمن؟ للجيографيا صح ولا لا؟ بما أننا
+
+97
+00:07:22,360 --> 00:07:26,620
+بتكلم عن أوروبا وبتكلم عن أفريقيا اشمالها 15% في
+
+98
+00:07:26,620 --> 00:07:31,840
+أوروبا لانتقال من الأم إلى الموليد وفي أفريقيا تصل
+
+99
+00:07:31,840 --> 00:07:37,770
+إلى 50% هل هذا الكلام له علاقة بالجيографيا؟قد
+
+100
+00:07:37,770 --> 00:07:42,630
+يكون له علاقة بتطور الطب في المنطقتين يعني هذا في
+
+101
+00:07:42,630 --> 00:07:47,210
+أوروبا الأم الحامل المصاب بال HIV تعطى drugs لمنع
+
+102
+00:07:47,210 --> 00:07:51,730
+انتقال الفيروس من ال .. أو تقليل فرص انتقال
+
+103
+00:07:51,730 --> 00:07:55,610
+الفيروس إلى اللي هو المولود وبالتالي النسبة بتكون
+
+104
+00:07:55,610 --> 00:08:00,790
+إيه؟ يشملها أقلفرح الـ HIV بينتقل من
+
+105
+00:08:00,790 --> 00:08:05,390
+Transplacetaly خلال الولادة أو حتى من ال breast
+
+106
+00:08:05,390 --> 00:08:09,110
+milk يعني ال breast feeding من الرضاعة الطبيعية
+
+107
+00:08:09,110 --> 00:08:14,290
+لذلك الأم المصابة بالـ HIV كإجراء وقاء يجب أن تمنع
+
+108
+00:08:14,290 --> 00:08:18,190
+من إرضاع طفلها رضاعة طبيعية وزي ما حكينا إذا كانت
+
+109
+00:08:18,190 --> 00:08:21,950
+معروفة ومشخصة يمكن أن تقطع بعض العقاقير لمنع
+
+110
+00:08:21,950 --> 00:08:29,320
+الانتقال إلى اللي هو الموضوع ال treatmentللـ HIV
+
+111
+00:08:29,320 --> 00:08:32,240
+طبعا أنا ماابدوش ادوشكوا كتير في موضوع ال
+
+112
+00:08:32,240 --> 00:08:36,380
+treatment لكن احنا مجبرين رصبا عندنا في ال HIV ان
+
+113
+00:08:36,380 --> 00:08:41,740
+نتكلم عن ال treatment لان اكتر الفيروسات المدروسة
+
+114
+00:08:41,740 --> 00:08:46,510
+و اللتي بوحي تلها عن عقاقيرهيعني هنحاول قدر الممكن
+
+115
+00:08:46,510 --> 00:08:52,270
+نقتصر ال treatment في بعض الصفحات البسيطة لكن
+
+116
+00:08:52,270 --> 00:08:56,330
+رأيها الأمر ان هو بالفعل ال HIV محتل مساحة ضخمة من
+
+117
+00:08:56,330 --> 00:09:04,300
+ال antiviral drugs فيها سماعاتHeart مش بالقلب يعني
+
+118
+00:09:04,300 --> 00:09:10,860
+وانما H A A R T وتعني highly active وكلمة highly
+
+119
+00:09:10,860 --> 00:09:14,980
+active يعني ذو فعالية عالية until it's a viral
+
+120
+00:09:14,980 --> 00:09:18,720
+therapy عرفنا إيش يعني heart؟Highly Active Anti
+
+121
+00:09:18,720 --> 00:09:24,840
+-Retroviral Therapy المقصود فيها أنه علاج للـ
+
+122
+00:09:24,840 --> 00:09:30,720
+Retrovirus الـHIV و highly active يعني فعال جدا
+
+123
+00:09:30,720 --> 00:09:36,880
+كلمة فعال جدازي مصطلحاتنا لمعاهد قصير كتير بيشوف
+
+124
+00:09:36,880 --> 00:09:40,580
+واحد أطول منه بشويه ايش بيقول عنه طويل جدا
+
+125
+00:09:40,580 --> 00:09:45,880
+فالمقارنة هنا نسبية كلهم قصير لو واحد طويل عادي او
+
+126
+00:09:45,880 --> 00:09:48,840
+لو واحد normal بيقول اتنين ايش بالهم اتنين اجسار
+
+127
+00:09:48,840 --> 00:09:54,700
+لكن الجسير بيشوف الطويل بيقول عنه طويل جدا، مظبوط؟
+
+128
+00:09:54,700 --> 00:09:59,280
+إذن هذا مصطلح qualitative مش quantitative او semi
+
+129
+00:09:59,280 --> 00:10:06,470
+quantitativeمش relative مش absolute وبالتالي نعني
+
+130
+00:10:06,470 --> 00:10:10,270
+فيه إن هذا العلاج هو من أفضل العلاجات اللي
+
+131
+00:10:10,270 --> 00:10:14,630
+استخدمناها على مين لل HIV مقارنة بما هو متوفر
+
+132
+00:10:14,630 --> 00:10:23,870
+وبتكون من زيدوفيودين ولمفيودين وده هتين عبارة عن
+
+133
+00:10:23,870 --> 00:10:27,410
+نوكليوسايد انهيبتر وعارفينش يعني نوكليوسايد
+
+134
+00:10:27,410 --> 00:10:27,910
+انهيبتر
+
+135
+00:10:32,170 --> 00:10:36,010
+الـ Transcription أو الـ Replication تمام؟ لما
+
+136
+00:10:36,010 --> 00:10:39,390
+يركب نوكليوسايد معينة بيوقفوها فبالتالي بيوقفوا
+
+137
+00:10:39,390 --> 00:10:42,450
+عملية الـ Transcription و Trans .. ليش؟ بالاضافة
+
+138
+00:10:42,450 --> 00:10:46,350
+إلى ما يسمى بـ Protease Inhibitor كلكم بتعرفوا أن
+
+139
+00:10:46,350 --> 00:10:49,690
+الريتروفيروس تميز بأنه بتنتج ال precursor
+
+140
+00:10:49,690 --> 00:10:53,050
+polypeptide و ال precursor polypeptide عشان يشتغل
+
+141
+00:10:53,050 --> 00:10:58,460
+بده Protease و يبقى فيها Proteaseإذا استطعت انا ان
+
+142
+00:10:58,460 --> 00:11:02,200
+انا اعمل انهيبشن لها ده لبروتياز فانا بمنع تكسير
+
+143
+00:11:02,200 --> 00:11:05,460
+ال precursor polypeptide وبالتالي بطلعش functional
+
+144
+00:11:05,460 --> 00:11:08,380
+protein بوجه ال replication تبع الفيروس، اذا
+
+145
+00:11:08,380 --> 00:11:13,370
+البروتياز inhibitor فكرة عظيمةدمجناها مع two
+
+146
+00:11:13,370 --> 00:11:19,370
+nucleoside inhibitors تشكل لنا عقاء أو خدنا نقول
+
+147
+00:11:19,370 --> 00:11:25,630
+وصفة regimen علاجية للـHIV سميناها highly active
+
+148
+00:11:25,630 --> 00:11:30,010
+antiretroviral therapy ال .. ال .. ال protein
+
+149
+00:11:30,010 --> 00:11:34,270
+inhibitor اسمه Indenavir Indenavir وزيدوا فيودين
+
+150
+00:11:34,270 --> 00:11:36,530
+وقلنا اللي لهم فيودين هدول هم ال nucleoside
+
+151
+00:11:36,530 --> 00:11:41,080
+inhibitorsمن مزايا انه effective in prolonging
+
+152
+00:11:41,080 --> 00:11:45,180
+life ايش يعني in prolonging life بيطول الأمر؟ طب
+
+153
+00:11:45,180 --> 00:11:47,920
+احنا فينا في ال .. في ال .. في الإسلام حد بينطول
+
+154
+00:11:47,920 --> 00:11:52,220
+الأمر؟ ايش رايكم؟ لأ ما هو التاني .. التاني غيب
+
+155
+00:11:52,220 --> 00:11:56,860
+التاني improving quality of life هذه موجودة بس ال
+
+156
+00:11:56,860 --> 00:12:03,290
+prolonging life في حد بيقدر يمد أمر حدهو المصطلح
+
+157
+00:12:03,290 --> 00:12:07,730
+.. المصطلح فيه ظاهري يبدو انه فيه خلال لكن في ..
+
+158
+00:12:07,730 --> 00:12:10,530
+في بعض ما امر طبيعي احنا حد فينا بيعرف اصلا جدش
+
+159
+00:12:10,530 --> 00:12:14,470
+الامر و ابتدا مايعرفش احنا كيف بيحسبوا .. بيحسبوا
+
+160
+00:12:14,470 --> 00:12:17,510
+او بيقولوا هذه الجملة effective in prolonging life
+
+161
+00:12:17,510 --> 00:12:21,750
+بيقولوا انه مثلا من دخول الاعراض الى الوفاة بدون
+
+162
+00:12:21,750 --> 00:12:27,870
+علاج X بدون علاج Y X بدون علاج Z X يعني في اندي
+
+163
+00:12:27,870 --> 00:12:31,390
+فترات معينة من .. من بداية دخول الاعراض الى الوفاة
+
+164
+00:12:32,180 --> 00:12:36,700
+اللي قال لو استخدمت أنا علاج و أعطاني مع مجموعة من
+
+165
+00:12:36,700 --> 00:12:42,040
+المرضى فترة عمر أطول، عاشوا أطول، فبجيب الفترة
+
+166
+00:12:42,040 --> 00:12:46,700
+اللي عاشوها أطول و بقول إنه زود عمر المرضى بشهرين،
+
+167
+00:12:46,700 --> 00:12:50,720
+بسنتين، بعشرين سنة، تمام؟ يبقى هذا المصطلح فيه
+
+168
+00:12:50,720 --> 00:12:55,210
+اللي بسميه هنا prolonging lifeimproving quality of
+
+169
+00:12:55,210 --> 00:12:59,650
+life تحسين جودة الحياة طبعا حياة مرضى ال aids حياة
+
+170
+00:12:59,650 --> 00:13:05,150
+عذاب كل الميكروبات اللي في الدنيا سواء كان ممرضة
+
+171
+00:13:05,150 --> 00:13:09,310
+أو غير ممرضة تعملهم أمراض ابتالي هو always sick
+
+172
+00:13:09,310 --> 00:13:14,400
+مافي عنده يعني وقت مافيش فيه sickلكن وجود هذا الـ
+
+173
+00:13:14,400 --> 00:13:20,100
+Drug رفع من اللي هو الـ CD4 count إلى أكتر من 200
+
+174
+00:13:20,100 --> 00:13:23,760
+وبالتالي قلل من إمكانية اللي هو ال infection
+
+175
+00:13:23,760 --> 00:13:28,000
+فاعطاه يعني بعض الفترات اللي هو ممكن ماكنش فيها
+
+176
+00:13:28,000 --> 00:13:34,180
+مريض بمرض آخر Reducing viral load هذا مؤشر على إنه
+
+177
+00:13:34,180 --> 00:13:41,160
+المريض بيستجيب لهذا العلاج ال disadvantage طبعازي
+
+178
+00:13:41,160 --> 00:13:44,420
+كل ال antiviral drugs انه does not cure the
+
+179
+00:13:44,420 --> 00:13:53,280
+chronic HIV infection احنا قلنا فيها ان ال .. ال
+
+180
+00:13:53,280 --> 00:13:57,120
+.. ال heart في كلمة heart بس بستخدمها لل children
+
+181
+00:13:57,930 --> 00:14:04,410
+مكوّن من زيدوفيودين ولموفيودين بالإضافة
+
+182
+00:14:04,410 --> 00:14:07,850
+إلى نونكليوسايد
+
+183
+00:14:07,850 --> 00:14:13,290
+ريفيرس ترانسكريبتيز انهيبترز اسمه EVA virans
+
+184
+00:14:17,100 --> 00:14:21,820
+البروتيز انهيبتر آخر غير الأولاني اسمه Nelfenadir
+
+185
+00:14:21,820 --> 00:14:26,420
+ضفناه لهذه المجموعة بيقول إنه بيعمل enhancement
+
+186
+00:14:26,420 --> 00:14:32,500
+للpotency و ال duration of the antiviral effect in
+
+187
+00:14:32,500 --> 00:14:38,300
+childrenبنقدر نقول ان ال heart الان ليس مجرد وصفة
+
+188
+00:14:38,300 --> 00:14:42,260
+واحدة و لا بأكتر من وصفة لكن هي عبارة عن مين؟ عن
+
+189
+00:14:42,260 --> 00:14:46,800
+خلطة من بعض العقاقير ال antiviral غالبا from two
+
+190
+00:14:46,800 --> 00:14:50,360
+to three classes ايش يعني ال two to three classes؟
+
+191
+00:14:50,360 --> 00:14:54,320
+يعني من صينفين او من ثلاث أصناف من العقاقير شوفنا
+
+192
+00:14:54,320 --> 00:14:58,040
+نوكليوسايد انهيبتور مظبوط شوفنا اللي بروتيز
+
+193
+00:14:58,040 --> 00:15:02,200
+انهيبتور شوفنا الان اللي هم نونوكليوسايد ريفيرس
+
+194
+00:15:02,200 --> 00:15:07,850
+ترانسكريبتيز انهيبتورمزمنة في ال treatment
+
+195
+00:15:07,850 --> 00:15:12,110
+زيدوفيودين والأزيدو ثايميدين انهيبط HIV
+
+196
+00:15:12,110 --> 00:15:16,770
+replication by interfering with proviral DNA
+
+197
+00:15:16,770 --> 00:15:21,450
+synthesis مين بتذكر شو يعني proviral DNA synthesis
+
+198
+00:15:21,450 --> 00:15:28,010
+او proviral؟لما اذكركوا في ال proofage ال proofage
+
+199
+00:15:28,010 --> 00:15:31,330
+هو ال DNA اللي صارله integration في ال host
+
+200
+00:15:31,330 --> 00:15:37,030
+فبالتالي هذا اللي هو ال DNA تبع ال HIV اللي صارله
+
+201
+00:15:37,030 --> 00:15:41,090
+integration في ال host DNA اي اسمه provariable DNA
+
+202
+00:15:41,090 --> 00:15:46,210
+اللي احنا بيقولنا ال ZWD و ال ZYD كلا هما بيعمل
+
+203
+00:15:46,210 --> 00:15:49,410
+inhibition لل replication من خلال ال interference
+
+204
+00:15:49,410 --> 00:15:55,630
+مع هذا اللي هو ال DNAلكن للأسف لا يستطيعوا انهم
+
+205
+00:15:55,630 --> 00:16:01,190
+يعملوا curing لخلايا already فيها اللي هو ال
+
+206
+00:16:01,190 --> 00:16:06,470
+provirus ليش؟ هم بيمنعوا ال replication تبعه، ولكن
+
+207
+00:16:06,470 --> 00:16:11,050
+ممكنش يشيلوه من مكانه، ممكنش ينزعوه من مكانه بتاعه
+
+208
+00:16:11,050 --> 00:16:15,970
+يبقى له موجود يعني لو خلصت الدوة، راح تحتيل عقار،
+
+209
+00:16:15,970 --> 00:16:21,880
+بيرجع ال DNA بتكاثر مرة أخرىStrains of HIV
+
+210
+00:16:21,880 --> 00:16:25,500
+resistant to ZDV اللي هو اللي قلنا عنه Zidovudine
+
+211
+00:16:25,500 --> 00:16:29,380
+have been isolated from patients receiving long
+
+212
+00:16:29,380 --> 00:16:33,120
+term ZDV therapy، إذن زي زي البكتيريا، يعني تستطيع
+
+213
+00:16:33,120 --> 00:16:36,300
+أنا برضه مالها إنها تقاوم اللي هو أو تبقى
+
+214
+00:16:36,300 --> 00:16:41,980
+resistant للعقاقيأيضًا الـ Zidovudine عنده effects
+
+215
+00:16:41,980 --> 00:16:48,980
+هيماتولوجي والذي يحدد من إمكانية
+
+216
+00:16:48,980 --> 00:16:56,200
+استخدامه في الإنسانالان كونه هذا toxic للإنسان و
+
+217
+00:16:56,200 --> 00:17:02,960
+خاصة للدم تبع الإنسان ممكن احنا نعمل حيلة اخرى
+
+218
+00:17:02,960 --> 00:17:06,380
+نعملها حتى في ال antibiotics ان نعمل اكتر من
+
+219
+00:17:06,380 --> 00:17:11,810
+antibiotic مع بعض مثلا و ل ZDVبإمكانها تتعامل مع
+
+220
+00:17:11,810 --> 00:17:19,190
+ديدانوسين وزلسة تابين لتخلص الميزة من كل ميزة و
+
+221
+00:17:19,190 --> 00:17:20,850
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+222
+00:17:20,850 --> 00:17:24,250
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+223
+00:17:24,250 --> 00:17:27,830
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+224
+00:17:27,830 --> 00:17:28,650
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+225
+00:17:28,650 --> 00:17:32,330
+تخلص الميزة من كل ميزة و تخلص الميزة من كل ميزة و
+
+226
+00:17:32,330 --> 00:17:37,120
+تخل300 جرام 300 جرام 300 جرام 300 جرام 300 جرام
+
+227
+00:17:37,120 --> 00:17:45,760
+300 جرام 300 جرام 300 جرام 300 جرام 300 جرام 300
+
+228
+00:17:45,760 --> 00:17:49,480
+جرام 300 جرام 300 جرام 300 جرام 300 جرام 300 جرام
+
+229
+00:17:49,480 --> 00:17:50,220
+300 جرام 300 جرام 300 جرام 300 جرام 300 جرام 300
+
+230
+00:17:50,220 --> 00:17:51,820
+300 جرام 300 جرام 300 جرام 300 جرام 300 جرام 300
+
+231
+00:17:51,820 --> 00:17:55,240
+جرام 300
+
+232
+00:17:55,240 --> 00:18:03,550
+جرامهو مقترح للطبيعي اللي هو غير مقاوم للـ ZDV
+
+233
+00:18:05,740 --> 00:18:08,920
+يعني لأي سبب من الأسباب صار عنده reaction، صار
+
+234
+00:18:08,920 --> 00:18:12,620
+عنده ضعف، صار عنده ألم، صار عنده side effect من ال
+
+235
+00:18:12,620 --> 00:18:18,360
+ZDV يبقى بنقدر نستخدم de-denosyncal replacement or
+
+236
+00:18:18,360 --> 00:18:22,460
+whose disease has progressed أو هؤلاء الأشخاص
+
+237
+00:18:22,460 --> 00:18:28,060
+الذين أعطوا ZDV ومع ذلك المرض مانا مش ماله بيتطور
+
+238
+00:18:28,060 --> 00:18:31,120
+وبيزداد سوءًا معناه الحاجة إن الفيروس صار يشمله
+
+239
+00:18:31,120 --> 00:18:38,210
+مقاوم لل ZDVميكانيزم الـ ZD-V بشكل مشابه لـ ZD-V
+
+240
+00:18:38,210 --> 00:18:44,870
+ثلاثة أخرى أدوات زلستيبين، ستابيودين ولمبيودين
+
+241
+00:18:44,870 --> 00:18:48,350
+تستخدم أيضًا في حالة مشابهة، مايعني في حالة
+
+242
+00:18:48,350 --> 00:18:51,750
+مشابهة؟ اللي هم .. اللي .. اللي .. اللي .. اللي ..
+
+243
+00:18:51,750 --> 00:18:53,770
+اللي قولنا عنهم الجثتين، الجثة الأولى أنه واحد
+
+244
+00:18:53,770 --> 00:18:56,910
+intolerant لـ ZD-V أو أن الـ disease has
+
+245
+00:18:56,910 --> 00:19:03,270
+progressed في وجود اللي هو ZD-Vمن بعض العقرقير
+
+246
+00:19:03,270 --> 00:19:08,390
+اللي بيستخدموها ك classes في ال antiviral drugs هم
+
+247
+00:19:08,390 --> 00:19:11,830
+ال protease inhibitors اعتقد انه شفنا مثالين عليهم
+
+248
+00:19:11,830 --> 00:19:16,610
+و non-nucleotide reverse transcriptase inhibitor
+
+249
+00:19:16,610 --> 00:19:19,510
+في كمان حاجة ما ذكرناش احنا ليها ال fusion
+
+250
+00:19:19,510 --> 00:19:23,550
+inhibitor ايش يعني fusion inhibitor؟انتوا عارفين
+
+251
+00:19:23,550 --> 00:19:30,330
+انه فاكرين ال GP120 وال GP41 اللي برتبته بمين؟ بال
+
+252
+00:19:30,330 --> 00:19:34,870
+receptor CD4 و ال co receptor هدولة التنين هو
+
+253
+00:19:34,870 --> 00:19:38,970
+المسؤولين عن بعد ذلك اللي هو ال sequence of fusion
+
+254
+00:19:38,970 --> 00:19:42,690
+لو صار فيه اي interference هذا بيمنع مين ل fusion
+
+255
+00:19:42,690 --> 00:19:49,660
+فبسموها fusion inhibitorsهل مازال الـ HIV على حاله
+
+256
+00:19:49,660 --> 00:19:55,180
+و لا فيه تطورات بتصير في الدنيا في هذا المجال؟ في
+
+257
+00:19:55,180 --> 00:20:04,400
+2007، قبل عشر سنوات، هذا المعلومات من كتاب 2010
+
+258
+00:20:04,400 --> 00:20:11,140
+-2011، ممكن تكون في تطورات أخرى وعققير أخرى الـ
+
+259
+00:20:11,140 --> 00:20:13,700
+FDA، الكل كنت تعرفه في الـ FDA، الـ Food and Drug
+
+260
+00:20:13,700 --> 00:20:14,320
+Administration
+
+261
+00:20:20,070 --> 00:20:27,370
+وهذا العقار بعمل blocking لل binding لل GP121 في
+
+262
+00:20:27,370 --> 00:20:30,190
+ال core receptor اللي هو اسمه CCR5
+
+263
+00:20:34,810 --> 00:20:40,370
+الـ GP121 مع الـ CD4 مع الـ GP41 مع الـ CCXR هذه
+
+264
+00:20:40,370 --> 00:20:45,110
+العملية إذا ما تمتش الـ HRV بسولوش entry فالـ
+
+265
+00:20:45,110 --> 00:20:48,890
+Marivalok بيعمل interference مع هذا ال binding
+
+266
+00:20:48,890 --> 00:20:51,610
+وبالتالي بيمنع الفيروس من الارتباط
+
+267
+00:20:54,780 --> 00:20:59,020
+الدراج في الارتباط يعني مش ضروري تكون 100% هذا
+
+268
+00:20:59,020 --> 00:21:02,700
+واحد، اتنين احنا بنعطي الدراج لمين؟ لو واحد بده
+
+269
+00:21:02,700 --> 00:21:06,240
+يوصيب ولا أصيب؟ أصيب، معناه حاجة انه في فيه فيه
+
+270
+00:21:06,240 --> 00:21:09,860
+فيه فيه فيه فيه في داخل الخلايا، يعني مابنقدرش
+
+271
+00:21:09,860 --> 00:21:13,560
+برضه كمان نعمل prevention term ل death disease
+
+272
+00:21:13,560 --> 00:21:16,700
+وعشان مايصيرش فيه resistance البنات بقولك انه it
+
+273
+00:21:16,700 --> 00:21:19,580
+should be used in combination with other
+
+274
+00:21:19,580 --> 00:21:24,660
+antiretroviral drugs يعنيبنخيفين عليه كتير، بدناش
+
+275
+00:21:24,660 --> 00:21:28,320
+ياسير، resistant اللي هو بسرعة، برضه في 2007 ال
+
+276
+00:21:28,320 --> 00:21:33,280
+FDA طلعت drug جديد وهذا ال drug أول drug بيشتغل
+
+277
+00:21:33,280 --> 00:21:37,860
+على أنزيم ال integraseطبعا فاكرين انتوا هنجود لأن
+
+278
+00:21:37,860 --> 00:21:40,520
+فينا three enzymes فاكرين هم؟ reverse
+
+279
+00:21:40,520 --> 00:21:45,000
+transcriptase و protease و integrase الان شوفنا
+
+280
+00:21:45,000 --> 00:21:47,580
+قبل شوية reverse transcriptase inhibitor وشوفنا
+
+281
+00:21:47,580 --> 00:21:51,520
+protease inhibitor هذا هو الكان الأول من صنف اللي
+
+282
+00:21:51,520 --> 00:21:56,280
+هم ال integrase انا اعتقد ان هذا يعني ممكن يكون له
+
+283
+00:21:56,280 --> 00:22:02,340
+أثر كويس في القضاء على ال HIV لو بالفعل كان فعال
+
+284
+00:22:02,340 --> 00:22:08,530
+بشكل جيد، ليش؟most of cells اللي بيصير فيها
+
+285
+00:22:08,530 --> 00:22:14,050
+infection بال HIV في الآخر في المحاصلة بتموت
+
+286
+00:22:14,790 --> 00:22:19,250
+المحاصرة بتموت فإذا الآن هذا ال drug منع ال
+
+287
+00:22:19,250 --> 00:22:23,290
+integration تنهار يبقى معناه يحكي انه هيمنع ال
+
+288
+00:22:23,290 --> 00:22:27,310
+common تبع اللي هو ال HIV وبتلاه ممكن يقضي على ال
+
+289
+00:22:27,310 --> 00:22:32,550
+HIV لكن مش فاهمين احنا بالضبط القالية اللي ال HIV
+
+290
+00:22:32,550 --> 00:22:37,790
+can survive in cells وغالبا مش هيكون لوحده كافي
+
+291
+00:22:37,790 --> 00:22:44,010
+للقضاء على ال HIVاسمه رالتي غريفير وهو الـfirst
+
+292
+00:22:44,010 --> 00:22:49,970
+drug to inhibit الـHIV encoded integrase ونفس
+
+293
+00:22:49,970 --> 00:22:55,310
+الجثة يمكن استخدام فيه المرضى اللي أولجه بقدر
+
+294
+00:22:55,310 --> 00:22:59,890
+انتريتروفيرل لكن فشلت هذي الانتريتروفيرل في خفض ال
+
+295
+00:22:59,890 --> 00:23:06,150
+viral load أو تحسين الـCD4 countالمصطلح اللي
+
+296
+00:23:06,150 --> 00:23:10,530
+أمامكم هذا مصطلح مر علينا قبل ذلك وناقشناه بعينيا
+
+297
+00:23:10,530 --> 00:23:16,350
+واسمه immune reconstitution syndrome وهذا ال
+
+298
+00:23:16,350 --> 00:23:19,650
+immune reconstitution syndrome من ضمن القضايا اللي
+
+299
+00:23:19,650 --> 00:23:24,170
+نقشناها سابقا في ان دور ال immune system في تدمير
+
+300
+00:23:24,170 --> 00:23:28,090
+بعض العضاء في خلال ال viral infection يعني ماكانش
+
+301
+00:23:28,090 --> 00:23:32,620
+السبب هو الفيروس مباشرة تم نرميهالـ Immune System
+
+302
+00:23:32,620 --> 00:23:34,560
+وجودنا هذه الكلام في Hepatitis B و Hepatitis C
+
+303
+00:23:34,560 --> 00:23:39,660
+واضح جدا لنا الآن تخيل لو واحد عنده HIV و عنده
+
+304
+00:23:39,660 --> 00:23:44,880
+Hepatitis B الآن لأن ال Immune System منخفض فلن
+
+305
+00:23:44,880 --> 00:23:50,100
+يكون هناك ضرر على مين؟ على الكبد لأن مافيش Immune
+
+306
+00:23:50,100 --> 00:23:54,860
+System يضر بمين؟ بالكبد لو علجنا ال Immune System
+
+307
+00:23:54,860 --> 00:24:00,950
+.. ال HIV و رفعنا ال CD4 countبالـ Highly Active
+
+308
+00:24:00,950 --> 00:24:04,460
+Antiretroviral Therapy اللي سميناها HARTهيصحى ال
+
+309
+00:24:04,460 --> 00:24:08,020
+immune system يقول انت ايش بتسوي هنا على Hepatitis
+
+310
+00:24:08,020 --> 00:24:12,600
+ايش انت بتسوي هنا و يقعد يقتل في الخلايا تبع الكبد
+
+311
+00:24:12,600 --> 00:24:16,840
+و يعمل destruction لمن؟ لل liver لذلك هم بيسموه
+
+312
+00:24:16,840 --> 00:24:20,700
+immune reconstitution syndrome صحى الجهاز المناع
+
+313
+00:24:20,700 --> 00:24:24,800
+اتحسن جهاز المناع فبدأ يشتغل على اللي هو الملفات
+
+314
+00:24:24,800 --> 00:24:27,800
+اللي قدامه اللي موجودة ومن ضمنها تدمير بعض
+
+315
+00:24:27,800 --> 00:24:33,810
+الانسجار المصابة بأخر فيروس طب ماهيش نعمل؟وإن إذا
+
+316
+00:24:33,810 --> 00:24:39,570
+كان عندنا مريض HIV لابد متى كان الأمر متاحا .. متى
+
+317
+00:24:39,570 --> 00:24:44,870
+كان الأمر متاحا لابد لنا عن البحث عن الأمراض
+
+318
+00:24:44,870 --> 00:24:51,070
+الأخرى وعلاجها قبل مين؟ قبل علاج اللي هو ال HIV
+
+319
+00:24:51,070 --> 00:24:55,290
+خشية انه زي ما حكينا يتحسن ال immune system عنده
+
+320
+00:24:55,290 --> 00:25:03,810
+يدور بهذا الاسم اللي بس ال diagnosis لل HIVطبعا من
+
+321
+00:25:03,810 --> 00:25:08,210
+أول ما ظهر هذا المرض بدأ موضوع ال screening يقلق
+
+322
+00:25:08,210 --> 00:25:15,570
+أو يقرق العاملين في القطاع الإبديمولوجي و في CDC و
+
+323
+00:25:15,570 --> 00:25:18,990
+طوروا فحص سريع جدا اسمه ELISA اللي هو ال enzyme
+
+324
+00:25:18,990 --> 00:25:24,790
+linked immunosorbent assay و الفحص كان الحقيقة
+
+325
+00:25:24,790 --> 00:25:30,030
+يعني very sensitive بمعنى أنه ال negative يكون
+
+326
+00:25:30,030 --> 00:25:35,350
+عندها negative حقيقيبينما مش specific وهذا هي من
+
+327
+00:25:35,350 --> 00:25:38,970
+معرم سمات ال screening test بتكون sensitive و
+
+328
+00:25:38,970 --> 00:25:40,290
+بتكونش specific
+
+329
+00:25:44,130 --> 00:25:47,890
+يعني بتستثنينها الـ negative الحقيقي لكن الـ
+
+330
+00:25:47,890 --> 00:25:51,470
+positive لابد انه اش نعمله confirmatory test
+
+331
+00:25:51,470 --> 00:25:58,110
+وبالتالي ال confirmatory test المستخدمة للـ HIV هي
+
+332
+00:25:58,110 --> 00:26:02,470
+نفس ال confirmatory test اللي بنستخدمها لل retro
+
+333
+00:26:02,470 --> 00:26:09,070
+virus ال HTLV-1 وHTLV-2 مين بتذكرها؟ فصفحات تانية
+
+334
+00:26:09,070 --> 00:26:11,570
+اللي هي
+
+335
+00:26:14,670 --> 00:26:21,490
+برضه مش عارفينها؟وسترن بلوت تكنيك وسترن بلوت تكنيك
+
+336
+00:26:21,490 --> 00:26:25,330
+طبعا هذه الصورة اللي أمامنا هي اللي هو ال الايزا
+
+337
+00:26:25,330 --> 00:26:28,930
+for hiv طبعا اللون الأصفر هذا بيعطينا انه reactive
+
+338
+00:26:28,930 --> 00:26:32,910
+وفي طبعا الآن فينا cartridge شايفينها ال hiv
+
+339
+00:26:32,910 --> 00:26:40,310
+موجودة بشكل تجاري وسهل وقطر الدم ثم إذا اتدهر
+
+340
+00:26:40,310 --> 00:26:43,590
+الخطين هدولة في بوستر إذا خط واحد في ال control
+
+341
+00:26:43,590 --> 00:26:47,070
+بيكون الفحص negative طبعاالـ Negative هذا لا
+
+342
+00:26:47,070 --> 00:26:50,950
+يستدعي تجارب أكتر، لكن الـ Positive هذا يستدعي
+
+343
+00:26:50,950 --> 00:26:56,630
+تجارب تجارب أكتر،
+
+344
+00:26:56,630 --> 00:26:58,630
+لكن الـ Positive هذا يستدعي تجارب تجارب أكتر، لكن
+
+345
+00:26:58,630 --> 00:26:58,730
+الـ Positive هذا يستدعي تجارب تجارب أكتر، لكن الـ
+
+346
+00:26:58,730 --> 00:27:00,070
+Positive هذا يستدعي تجارب تجارب أكتر، لكن الـ
+
+347
+00:27:00,070 --> 00:27:00,390
+Positive هذا يستدعي تجارب تجارب أكتر، لكن الـ
+
+348
+00:27:00,390 --> 00:27:00,970
+Positive هذا يستدعي تجارب تجارب أكتر، لكن الـ
+
+349
+00:27:00,970 --> 00:27:01,790
+Positive هذا يستدعي تجارب تجارب أكتبس ما بكشفش فيه
+
+350
+00:27:01,790 --> 00:27:05,990
+عن مين عن الانتي و اللي بكشف عن الانتجن باستخدام
+
+351
+00:27:05,990 --> 00:27:09,990
+جنة اللي هو primary و secondary antibodies واحد
+
+352
+00:27:09,990 --> 00:27:14,030
+منهم انزين برضه conjugated و العملية هي فانا
+
+353
+00:27:14,030 --> 00:27:17,490
+هحطلكوا هنا link اللي بدي حابب شوف اللي هو الفيديو
+
+354
+00:27:17,490 --> 00:27:21,110
+كيف بيشتغل من الف إلى الياء في ال western blot
+
+355
+00:27:21,110 --> 00:27:24,790
+techniqueطبعا المهم انكوا تطلعوا على التكنيك حتى
+
+356
+00:27:24,790 --> 00:27:27,710
+لو ما اشتغلتوش في المعمل يعني مجرد رأيتكوا اقولوا
+
+357
+00:27:27,710 --> 00:27:31,030
+كيف ناس بتشتغلوا من الف الى الياه هذا بيعطيكوا
+
+358
+00:27:31,030 --> 00:27:36,250
+فكرة جيدة عن هذا الفحص طيب
+
+359
+00:27:36,250 --> 00:27:39,330
+هذا بالنسبة لل diagnostic test اللي هم جونا
+
+360
+00:27:39,330 --> 00:27:43,450
+screening و مين و confirmatory test جونا الايزا
+
+361
+00:27:43,450 --> 00:27:48,370
+بالاضافة الى ال western blot ال prognostic test
+
+362
+00:27:55,420 --> 00:28:04,880
+في كام فحص اسمه HIV B24 يستخدموه ك quantitative
+
+363
+00:28:04,880 --> 00:28:11,640
+measure يجيسوا فيه ال HIVوكان لفترة معينة هو يعني
+
+364
+00:28:11,640 --> 00:28:18,900
+المعتمد لكن محدد ما بدأت فكرة انه ندور على ال CD4
+
+365
+00:28:18,900 --> 00:28:25,740
+count لجوا ان ال CD4 count أدق بكثير من ال P24
+
+366
+00:28:25,740 --> 00:28:30,760
+وبالتالي أصبح ال CD4 count او ما يسمى بال serial
+
+367
+00:28:30,760 --> 00:28:35,620
+CD4 count ليش serial؟ لأنه متكرر يعني مش مرة واحدة
+
+368
+00:28:35,620 --> 00:28:44,560
+وانما بشكل مستمريفجر متفقين على ان ال P24 تم يعني
+
+369
+00:28:44,560 --> 00:28:50,820
+ايه باستبعاده واستبعاده من مين؟ Serial CD4 count
+
+370
+00:28:50,820 --> 00:28:54,520
+طب جالهم هذا CD4 count معبر عن مين؟ عن ال immune
+
+371
+00:28:54,520 --> 00:28:57,850
+system طب بدنا حاجة تانية انها تتعبر عنالفيروس
+
+372
+00:28:57,850 --> 00:29:03,270
+نفسه فجعله يتكلم عن الـViral Load أو الـViral RNA
+
+373
+00:29:03,270 --> 00:29:09,250
+الـHIV Viral RNA ويسمّى هذه الحاجة الـHIV Viral
+
+374
+00:29:09,250 --> 00:29:12,890
+Load ويتم الكشف عنه بالـ RT أو Reverse
+
+375
+00:29:12,890 --> 00:29:18,050
+Transcriptase PCR إذا
+
+376
+00:29:18,050 --> 00:29:21,250
+فاندي two parameters اللي هم مين اللي هم الـCD4
+
+377
+00:29:21,250 --> 00:29:24,470
+count والتانية الـHIV Viral Load
+
+378
+00:29:27,500 --> 00:29:34,840
+طلع على اللوحة دي اللوحة اللي رامناها مكونة من
+
+379
+00:29:34,840 --> 00:29:38,060
+لونين رئيسيين، اللون الأزرق شايفينه؟ واللون التاني
+
+380
+00:29:38,060 --> 00:29:43,080
+عنها أحمر، الأحمر هو الـHIV RNA copies وكلمة HIV
+
+381
+00:29:43,080 --> 00:29:46,960
+RNA copies معناه أخر لمين لـViral Loads وعالجهة
+
+382
+00:29:46,960 --> 00:29:52,180
+الأخرى CD4 T lymphocyte count cells per cubic
+
+383
+00:29:52,180 --> 00:29:57,220
+millimeterلما بدأنا في ال infection او قبل ال
+
+384
+00:29:57,220 --> 00:30:01,780
+infection كان في اندي الرقم تبع ال CD4 جداش حوالي
+
+385
+00:30:01,780 --> 00:30:07,660
+1200 خلية per cubic millimeter و الفيروس جداش
+
+386
+00:30:10,110 --> 00:30:15,750
+بين ايه؟ بينها ماله؟ Zero مافي عندي viruses يبجي
+
+387
+00:30:15,750 --> 00:30:19,510
+هذا كان at maximum وهذا شماله minimum مافيش Zero
+
+388
+00:30:19,510 --> 00:30:22,830
+يعني لو قاعدت انا اعمل علاقة بقول علاقة ايش بينهم
+
+389
+00:30:22,830 --> 00:30:27,070
+اقولها علاقة عكسية لما كان هذا مرتفع هذا كان منخفض
+
+390
+00:30:27,070 --> 00:30:32,910
+جدا اطلعوا على ال CD4 بالظبط كيف ماشية وعلى جبالها
+
+391
+00:30:32,910 --> 00:30:39,700
+شمالههذه اللي بيسموها ال perfect inverse relation
+
+392
+00:30:39,700 --> 00:30:45,720
+العلاقة العكسية التامة إذا ارتفع هذا لإنه أصلا سبب
+
+393
+00:30:45,720 --> 00:30:52,920
+انخفاض ال CD4 هو ارتفاع عدد ال multiplication اللي
+
+394
+00:30:52,920 --> 00:30:59,080
+أدى لقتل هذه الخلايا طبعا بتلاحظوليماعرفش نمشي مع
+
+395
+00:30:59,080 --> 00:31:02,720
+بعض، عشان مهم .. مهم .. مهم ال .. ال .. الخطوة دي
+
+396
+00:31:02,720 --> 00:31:07,960
+ال primary infection weeks تنخفض، بعدين تعود ترتفع
+
+397
+00:31:07,960 --> 00:31:12,200
+إلى مستوى معين، و بعدين .. شوفتوا القطر هذا في
+
+398
+00:31:12,200 --> 00:31:16,180
+الكلمة ماعنى القطر هذا؟ انه بدأنا نتكلم مش
+
+399
+00:31:16,180 --> 00:31:19,880
+إسرابية، نتكلم عن إيه؟ شهور أو سنوات، يعني القطر
+
+400
+00:31:19,880 --> 00:31:25,870
+هذا اتغيرنا من weeks إلى مين؟ إلى شهورهذا المرحلة
+
+401
+00:31:25,870 --> 00:31:28,430
+المتعرفة عليه في ال curves لما انا ماقلتش احطينا
+
+402
+00:31:28,430 --> 00:31:32,350
+دولة مانحك ان في cut في قطر زماني بين هذه الأشياء
+
+403
+00:31:32,350 --> 00:31:40,610
+طيب ما زلنا لو أخدنا خط أفقي سبعمية خمسمية أربعمية
+
+404
+00:31:40,610 --> 00:31:46,630
+متى وصلنا طلعه لجداش شوف المقطة هذه العمودي من
+
+405
+00:31:46,630 --> 00:31:52,550
+جانب هنا لما وصلنا هنا لو أخدنا خطأخدنا وصلنا مين؟
+
+406
+00:31:52,550 --> 00:31:57,890
+200 ..الان هذا ال windows او ال window ها دي اسمها
+
+407
+00:31:57,890 --> 00:32:00,710
+clinical latency متى بيبقى اللي تنسي شعار اللي
+
+408
+00:32:00,710 --> 00:32:04,590
+تنسي؟ common سريري يعني لا يظهر على المريض اي
+
+409
+00:32:04,590 --> 00:32:09,110
+اشارة متى بيبقى تظهر على الاشارات؟ لما نزل مسترة
+
+410
+00:32:09,960 --> 00:32:15,200
+الـ CD4 count إلى أقل من 200 بدأت تظهر عليه
+
+411
+00:32:15,200 --> 00:32:19,520
+repeated infection من very simple microorganisms
+
+412
+00:32:19,520 --> 00:32:22,340
+زي الـ Candida، زي الكابوساركومة، زي الـ
+
+413
+00:32:22,340 --> 00:32:24,780
+Pneumocystis Girovici اللي قلنا لك هو عبارة عن
+
+414
+00:32:24,780 --> 00:32:28,480
+فنجس أو ييست، كان يعتقد أنه في السابق أنه برازيل،
+
+415
+00:32:28,480 --> 00:32:33,800
+بالمقابلكل ما ذكرناه من انخفاض كان مقابله إشي منها
+
+416
+00:32:33,800 --> 00:32:37,480
+صعود، ارتفاع في مين؟ في ال viral load، كمان مرة ال
+
+417
+00:32:37,480 --> 00:32:42,380
+viral load أخد peak معينة تمام؟ و بعدين استقر و
+
+418
+00:32:42,380 --> 00:32:47,040
+التفع ارتفاع بطيء جدا، هذا ال normal course، بطيء
+
+419
+00:32:47,040 --> 00:32:50,220
+جدا، لاحظوا في السنوات الأخيرة اللي هي جرية من
+
+420
+00:32:50,220 --> 00:32:58,730
+مين؟والذي أقل من 200 الفيرال لود ارتفع كبير وهنا
+
+421
+00:32:58,730 --> 00:33:03,730
+قد تحدث الوفاة لما يصل الرقم ترعنى فوق العشرة أو
+
+422
+00:33:03,730 --> 00:33:07,150
+الست أو بين عشرة أو ست أو بين عشرة أو ست أبعاء ملي
+
+423
+00:33:07,150 --> 00:33:12,300
+لترهناك علاقة وطيدة نستطيع من خلالها ان نعمل
+
+424
+00:33:12,300 --> 00:33:18,180
+follow-up نشوف هل في تقدم او في سوق ل الحالة يعني
+
+425
+00:33:18,180 --> 00:33:21,840
+progression ل ال disease ولا regression ل ال
+
+426
+00:33:21,840 --> 00:33:25,980
+disease من خلال ال two parameters اللي هم من CD4 و
+
+427
+00:33:25,980 --> 00:33:29,380
+ال viral load و ال viral load معبر عن مين قلنا عن
+
+428
+00:33:29,380 --> 00:33:34,730
+ال HIV RNA copiesالـ HIV RNA copies معبّر أيضًا
+
+429
+00:33:34,730 --> 00:33:39,030
+على العدد اللي هو الفيروسات اللي مولودة في الإنسان
+
+430
+00:33:39,030 --> 00:33:45,370
+طيب ال prevention ال risk طلع الجملة الأولى
+
+431
+00:33:45,370 --> 00:33:49,590
+والجملة التانية عشان بدنا نكون دائمًا نفهم إن
+
+432
+00:33:49,590 --> 00:33:53,970
+الأجانب ما بيحبوا يحكوا الحقيقة في هذا الموضوع ال
+
+433
+00:33:53,970 --> 00:33:57,090
+risk of contracting HIV increases with the number
+
+434
+00:33:57,090 --> 00:34:01,780
+of sexual partners كل ما زاد عددالشركاء الجنسيين
+
+435
+00:34:01,780 --> 00:34:07,520
+كل ما زاد احتمالية اللي هو اخذ او اقتصاد ال HIV
+
+436
+00:34:07,520 --> 00:34:13,180
+طبعا ايش التعبير المخفف المستخدم من قبلهم عشان
+
+437
+00:34:13,180 --> 00:34:17,040
+ينصحوا a change in the lifestyle ايش يعني change
+
+438
+00:34:17,040 --> 00:34:20,060
+in the lifestyle؟تغيير في أسلوب الحياة، أيش تغيير
+
+439
+00:34:20,060 --> 00:34:24,000
+في أسلوب الحياة؟ يعني التزم بالتعليم الدينية، سواء
+
+440
+00:34:24,000 --> 00:34:27,760
+كانت الإسلامية ولا المسيحية ولا اليهودية، بتحرم
+
+441
+00:34:27,760 --> 00:34:31,120
+الزنا، مظبوط ولا مظبوط؟ وبالتالي، لكن لا يستطيعوا
+
+442
+00:34:31,120 --> 00:34:35,340
+يقولوا هذا الكلام، لأن هم مش معنيين بإنهم يوقفوا
+
+443
+00:34:35,340 --> 00:34:40,730
+هذا المفهومالتغيير في طريقة الحياة سيقوم بالتقليد
+
+444
+00:34:40,730 --> 00:34:43,950
+أو تقليد الرغم من هذا التغيير الهيوغو من خلال
+
+445
+00:34:43,950 --> 00:34:48,450
+تنسيق دماغ يتم إيقافه، لماذا؟ لأنه الآن مافيش أي
+
+446
+00:34:48,450 --> 00:34:52,210
+دونار إلا بيفحصه، حتى الآن في غزة من سنة ألف
+
+447
+00:34:52,210 --> 00:34:56,090
+وتسعمائة، تسعين أو واحدة تسعية، مش متأكد بالضبط
+
+448
+00:34:56,090 --> 00:35:01,760
+التاريخهذا العام بتدخل فيه خدمة اللي هو الـ HIV
+
+449
+00:35:01,760 --> 00:35:07,620
+testing لكل blood bag تمام؟ وبالتالي جثة انه ينتقل
+
+450
+00:35:07,620 --> 00:35:11,920
+عن طريق blood bag هذا او blood transfusion هذا أمر
+
+451
+00:35:11,920 --> 00:35:15,820
+غير وارد لكن ما زال ال risk اللي بتعاطف منه انها
+
+452
+00:35:15,820 --> 00:35:22,780
+المخدرةAZA او AZT had been shown to be effective
+
+453
+00:35:22,780 --> 00:35:28,460
+in preventing transmission of HIV from mother to
+
+454
+00:35:28,460 --> 00:35:32,340
+the fetus فكدا ما كنا نجيب شوية أفريقيا و أوروبا
+
+455
+00:35:32,340 --> 00:35:36,440
+لما بيناكوا خمستاشر إلى خمسين بالمية و بيناكوا قد
+
+456
+00:35:36,440 --> 00:35:41,240
+لا تكون الفروقات بنسبة ليهتين نسبتين بسبب
+
+457
+00:35:41,240 --> 00:35:44,180
+الجغرافيا انها بسبب التطور الطبي وسبب ال medical
+
+458
+00:35:44,180 --> 00:35:48,690
+treatment هذا احد الدخلات اللي قللت منالإيصابة
+
+459
+00:35:48,690 --> 00:35:51,490
+الأطفال وطالع عايشة النتيجة كانت الـ incidence of
+
+460
+00:35:51,490 --> 00:35:54,950
+HIV infection in the baby was reduced by two
+
+461
+00:35:54,950 --> 00:36:00,110
+thirds يعني من كل تلاتة كان المفروض انه مصابه صار
+
+462
+00:36:00,110 --> 00:36:02,610
+واحد اللي فقط ايه او الاحتمالية انه ينصاب انه
+
+463
+00:36:02,610 --> 00:36:07,560
+ينصاب واحد فقطThe management of healthcare workers
+
+464
+00:36:07,560 --> 00:36:11,880
+وهذا نقطة لكم انتوا اللي بتعملونا في مجال التحديث
+
+465
+00:36:11,880 --> 00:36:16,440
+الطبية و اكتر ناس بنغزوا قبر اذا كانوا ما اتبعوش
+
+466
+00:36:16,440 --> 00:36:20,740
+تعليمات الا انا بنات السياسة العامة عدم ارجاع ال
+
+467
+00:36:20,740 --> 00:36:28,320
+needle الى ال wild cap تبعته، ليش؟ ليش احنا بنغلط؟
+
+468
+00:36:28,870 --> 00:36:34,370
+أول حاجة الإرهاق اللي ممكن يصيب العاملين في المجال
+
+469
+00:36:34,370 --> 00:36:40,930
+الصحي كبير، ضعف النظر اللي بيصاحب التقدم في السن
+
+470
+00:36:40,930 --> 00:36:42,070
+تمام؟
+
+471
+00:36:44,950 --> 00:36:49,870
+الانسان بيكون تعبان فتركيزه بيكون اقل ضغط العمل
+
+472
+00:36:49,870 --> 00:36:54,070
+بعض الأحيان برضه بيأثر على هذا العمل لذلك القاعدة
+
+473
+00:36:54,070 --> 00:36:57,290
+العامة بتقول انه don't recap the needle dispose
+
+474
+00:36:57,290 --> 00:37:05,150
+the needle فيه needle box خاص فيها العمل لكن على
+
+475
+00:37:05,150 --> 00:37:07,990
+الرغم من ذلك بيقولوا انه على الرغم من كل
+
+476
+00:37:07,990 --> 00:37:16,880
+الاحتياطاتIncidents occur يعني الحالات تتحدث
+
+477
+00:37:16,880 --> 00:37:24,340
+فبقول إنه يا دلترا إذا صار فيه needle injury لوحد
+
+478
+00:37:24,340 --> 00:37:27,900
+من العاملين في المجال الصحي إيش نعمله؟ بقول هذا
+
+479
+00:37:27,900 --> 00:37:32,880
+قضية قضية قضية جدالية ليه جدالية؟ بقول أبي أعطيه
+
+480
+00:37:32,880 --> 00:37:36,840
+مثلا prophylaxis antiviral prophylaxis زي ال AZT
+
+481
+00:37:38,530 --> 00:37:41,710
+طبعا هنا لا جدش نعطيه نعطيه ليوم واحد و لا نعطيه
+
+482
+00:37:41,710 --> 00:37:45,510
+لأسبوع و لا نعطيه لشهر مش جادين نحدد protocol
+
+483
+00:37:45,510 --> 00:37:51,810
+للأشخاص الذين اتعرضونا لدماء مصابة بال HIV
+
+484
+00:37:51,810 --> 00:37:58,890
+الفاكسينز هي بجثة طويلة طويلة جدا لحقيقة و كل سنة
+
+485
+00:37:59,980 --> 00:38:03,460
+بنقرع في الأخبار انه هناك زي ما احنا الآن كاتبين
+
+486
+00:38:03,460 --> 00:38:07,360
+هنا بالظبط clinical trials for several vaccines
+
+487
+00:38:07,360 --> 00:38:10,800
+are in progress يعني وكلمة clinical trial يا بنات
+
+488
+00:38:10,800 --> 00:38:16,540
+هي مرحلة متقدمة جدا للفحص
+
+489
+00:38:16,540 --> 00:38:18,920
+تبع ال vaccine يعني ال vaccine بيكون مرة و مراحل
+
+490
+00:38:18,920 --> 00:38:24,100
+كتيرة أخرها هتكون مين ال clinical trial تقريبا كل
+
+491
+00:38:24,100 --> 00:38:27,500
+سنة بيطلع واحد او اتنين في الأخبار انه another
+
+492
+00:38:27,500 --> 00:38:31,470
+clinical trial والسنة اللي بعدهاما بنسمع عنهم
+
+493
+00:38:31,470 --> 00:38:35,050
+اخبار تبارك على انهم ايه؟ انهم انهم فشلوا انهم
+
+494
+00:38:35,050 --> 00:38:36,870
+يعني يعطوا النسبة
+
+495
+00:38:36,870 --> 00:38:57,670
+الالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالالال
+
+496
+00:38:58,250 --> 00:39:02,730
+أحد الأسباب اللي بتخلينا نفشل في إنتاج اللي هو هذا
+
+497
+00:39:02,730 --> 00:39:05,890
+الفاكسين والمرة جاي ان شاء الله بنكمل
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LqNgTpGYkso_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LqNgTpGYkso_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..cefb6c2d7e9f5fdc2ef73582da6ed5b4eafeb8d6
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/LqNgTpGYkso_postprocess.srt
@@ -0,0 +1,1612 @@
+1
+00:00:21,460 --> 00:00:23,820
+بسم الله الرحمن الرحيم، الحمد لله رب العالمين و
+
+2
+00:00:23,820 --> 00:00:26,540
+الصلاة والسلام وعلى سيدنا محمد وعلى آله وصحبه ومن
+
+3
+00:00:26,540 --> 00:00:29,820
+ساعد بيه اليوم الدين، أما بعد كما وعدناكم في
+
+4
+00:00:29,820 --> 00:00:35,440
+المحاضرة السابقة، نعرض بعض الكرتون الموضح للأفكار
+
+5
+00:00:35,440 --> 00:00:40,140
+اللي درسناها من بداية هذا الفصلولننظر إلى هذه
+
+6
+00:00:40,140 --> 00:00:46,520
+الصورة ونتحدث عن الفيروس وهذا بيعطينا انطباع عن
+
+7
+00:00:46,520 --> 00:00:50,980
+المصطلح اللى تحدثنا به اكوزا هيدرال او عشرون
+
+8
+00:00:50,980 --> 00:00:55,860
+الوجوه ان الفيروس مكون من كبسيد مكونة من مثلثات
+
+9
+00:00:55,860 --> 00:01:01,320
+بيعطيها الشكل اللى هو الكراوي في المحصرةلكن لابد
+
+10
+00:01:01,320 --> 00:01:02,260
+للاطلاع
+
+11
+00:01:19,140 --> 00:01:23,340
+تعمل عملية الهواتف الخاصة لكي تقوم بتجريب الفيروس،
+
+12
+00:01:23,340 --> 00:01:27,660
+وإعادة إعادة إعادة تجريب الفيروس، وإعادة تجريب
+
+13
+00:01:27,660 --> 00:01:27,940
+الفيروس، وإعادة تجريب الفيروس، وإعادة تجريب
+
+14
+00:01:27,940 --> 00:01:28,120
+الفيروس، وإعادة تجريب الفيروس، وإعادة تجريب
+
+15
+00:01:28,120 --> 00:01:30,060
+الفيروس، وإعادة تجريب الفيروس، وإعادة تجريب
+
+16
+00:01:30,060 --> 00:01:32,280
+الفيروس، وإعادة تجريب الفيروس، وإعادة تجريب
+
+17
+00:01:32,280 --> 00:01:36,500
+الفيروس، وإعادة تجريب الفيروس، وإعادة تجريب
+
+18
+00:01:36,500 --> 00:01:41,660
+الفيروس، وإعادة تجريب الفيروس، وإعادة تجريب
+
+19
+00:01:41,660 --> 00:01:48,340
+الفيروس، وإعادة
+
+20
+00:01:56,420 --> 00:02:02,940
+في المحصلة اللى رأيناه هو عبارة عن virus ارتبط به
+
+21
+00:02:02,940 --> 00:02:07,760
+host cell لم يدخل الى الداخل وانما عمل injection
+
+22
+00:02:07,760 --> 00:02:13,140
+للمادة الوراثية وهذه سماء من سمات ال bacterial
+
+23
+00:02:13,140 --> 00:02:17,160
+viruses او ال bacteriophages يعني غالبا لا نجدها
+
+24
+00:02:17,160 --> 00:02:21,910
+في ال animal viruses لكن تم تمثيلها بهذا الشكلو ال
+
+25
+00:02:21,910 --> 00:02:25,110
+DNA ذهب إلى ال nucleus و في ال nucleus صارله
+
+26
+00:02:25,110 --> 00:02:29,250
+transcription و بعدين ال mRNA طلع لل cytoplasm و
+
+27
+00:02:29,250 --> 00:02:34,070
+ال cytoplasm صارله translation و طلع لبروتينات و
+
+28
+00:02:34,070 --> 00:02:39,770
+في المحصلة ال virus عمل تحليل لل cell membrane و
+
+29
+00:02:39,770 --> 00:02:44,190
+خرج إلى خارج الخلية كبروجيني كلمة بروجيني يعني
+
+30
+00:02:44,190 --> 00:02:48,250
+سلالة او منتج من منتجات هذا ال virus
+
+31
+00:02:52,410 --> 00:02:54,950
+بنشوف الآن ال viral replication و ال viral
+
+32
+00:02:54,950 --> 00:03:00,270
+replication مرتبط جوننا كمان مرة بنوع المادة
+
+33
+00:03:00,270 --> 00:03:04,070
+الوراثية هل هي double-stranded DNA او single
+
+34
+00:03:04,070 --> 00:03:08,630
+-stranded DNA و مرتبط بكمان انه RNA و اذا كان ال
+
+35
+00:03:08,630 --> 00:03:11,610
+RNA هل هو positive sense ولا negative sense ولا
+
+36
+00:03:11,610 --> 00:03:16,490
+كلا هما اللي هما ال double-stranded RNA فدعونا نرى
+
+37
+00:03:16,490 --> 00:03:18,430
+ايضا هذا العرض
+
+38
+00:03:20,590 --> 00:03:25,330
+الفيروسات مختلفة بسبب نوع النوكلياك الذي يمتلكه و
+
+39
+00:03:25,330 --> 00:03:30,030
+اذا كانوا مغامرين او انفلوكا كل مختلفة تنتج في
+
+40
+00:03:30,030 --> 00:03:35,250
+مراتب مختلفة في حياته مغامر و انفلوكا سيقومون
+
+41
+00:03:35,250 --> 00:03:41,570
+بتواصل و تدخل مستخدم مختلفاAnimal viruses without
+
+42
+00:03:41,570 --> 00:03:45,290
+an envelope are referred to as naked viruses. They
+
+43
+00:03:45,290 --> 00:03:48,450
+bind to the surface of the host cell and inject
+
+44
+00:03:48,450 --> 00:03:51,550
+their DNA into the host cell in a manner similar
+
+45
+00:03:51,550 --> 00:03:57,090
+to bacteriophages الانفيلوفد
+
+46
+00:03:57,090 --> 00:03:59,550
+فيروس طبعا بطريقة مختلفة بحيث انه بيصير فيه
+
+47
+00:03:59,550 --> 00:04:00,830
+membrane fusion
+
+48
+00:04:16,010 --> 00:04:22,490
+النوع التالت بيصيرله اندو سايتوسز اندو هو مكتوب
+
+49
+00:04:22,490 --> 00:04:25,170
+انه فاجو سايتوسز بس في الواقع اندو سايتوسز
+
+50
+00:04:32,190 --> 00:04:34,990
+عندما يدخل الفيروس في المخزن، يتعامل الجزء الخارق
+
+51
+00:04:34,990 --> 00:04:38,590
+والداخلية من المخزن مع بعضها، ويتم إطلاق الكابسيت
+
+52
+00:04:38,590 --> 00:04:43,050
+إلى الـCytoplasm. في هذه اللحظة، يفتح الكابسيت
+
+53
+00:04:43,050 --> 00:04:46,770
+ويطلق المواد الجينية الفيروية إلى جزء من جسم
+
+54
+00:04:46,770 --> 00:04:49,810
+المخزن.هذه العملية نسميها Uncoating، اللي أخيرة
+
+55
+00:04:49,810 --> 00:04:55,950
+الجزء المهم بالـ Animation هو نوع المادة اللي
+
+56
+00:04:55,950 --> 00:04:58,550
+ورثية وين بيصير له عملية تكاثر
+
+57
+00:05:01,130 --> 00:05:06,530
+عندما يدخل جنوب DNA واحد من البرفو فيروس مصطلح و
+
+58
+00:05:06,530 --> 00:05:10,660
+يهاجم نموهأحنا اللي هنتحدث عن مين، هنتحدث على
+
+59
+00:05:10,660 --> 00:05:16,480
+single-stranded DNA زي البرفو فيروس من وين دخل،
+
+60
+00:05:16,480 --> 00:05:20,840
+الأن من وين رايح، متجه، مهم جدا، نعرف وين العملية
+
+61
+00:05:20,840 --> 00:05:26,320
+بتكاثر وإن كل ال DNA فيروس بتكاثروا في نواة، يعني
+
+62
+00:05:26,320 --> 00:05:29,380
+هذا ال box virus بتكاثر في وين؟ في ال cytoplasm،
+
+63
+00:05:29,380 --> 00:05:33,680
+هذه كمان نقاط بدنا نكون عارفينها a complementary
+
+64
+00:05:33,680 --> 00:05:36,820
+strand is produced for the single-stranded viral
+
+65
+00:05:36,820 --> 00:05:41,730
+DNAThis DNA is then replicated normally Messenger
+
+66
+00:05:41,730 --> 00:05:45,090
+RNA is transcribed and transported into the
+
+67
+00:05:45,090 --> 00:05:48,670
+cytoplasm زي ما انا متفقين العملية كلها في الآخر
+
+68
+00:05:48,670 --> 00:05:54,930
+متمحورة حول ال RNA و احنا المرة الماضية توقفنا عند
+
+69
+00:05:54,930 --> 00:05:58,450
+في المحاضرة توقفنا عند ال RNA و اننا بده بده مننا
+
+70
+00:05:58,450 --> 00:06:04,070
+يعني محاضرة فبالتالي التمحور هذاهو محور فهمنا
+
+71
+00:06:04,070 --> 00:06:07,130
+عملية الـ replication أساسا، قلنا إذا كان positive
+
+72
+00:06:07,130 --> 00:06:12,270
+-stranded بده يتحول مباشرة can act as an messenger
+
+73
+00:06:12,270 --> 00:06:16,050
+RNA، لكن إذا negative-strand بده وإذا DNA غير،
+
+74
+00:06:16,050 --> 00:06:24,710
+يعني كل مادة وراثية في الآخر ستسعى للحصول علىMRNA
+
+75
+00:06:24,710 --> 00:06:28,630
+عشان أصير فيه Early Transcription و Translation
+
+76
+00:06:28,630 --> 00:06:32,610
+والـ Early Transcription و Translation بتمهد لمين؟
+
+77
+00:06:32,610 --> 00:06:38,090
+تمهد للـ Late Transcription
+
+78
+00:06:38,330 --> 00:06:41,090
+وفي مرحلة في النص بتاعة ننساها اللي هي ال genome
+
+79
+00:06:41,090 --> 00:06:46,270
+replication ان هذه البروتينات
+
+80
+00:06:46,270 --> 00:06:50,810
+الأولى مسؤولة عن أيضا مضاعفة ال genome لأن في
+
+81
+00:06:50,810 --> 00:06:54,770
+الآخر الفيروس هو عبارة عن protein كوتل والكابسيد
+
+82
+00:06:54,770 --> 00:07:01,540
+زاد اللي هو المادة اللي وراها فيههي تنتج كبسوميرات
+
+83
+00:07:01,540 --> 00:07:06,180
+عامة في الوقت بعد أن بدأت التنسيق، تدخل
+
+84
+00:07:06,180 --> 00:07:10,460
+الكبسوميرات في نوكليوس المستخدم، ويجمع الـ V-Rions
+
+85
+00:07:10,460 --> 00:07:13,240
+التي تحتوي على DNA واحدة منها
+
+86
+00:07:17,840 --> 00:07:34,960
+لأن كدا ماعنده بروستراندت نتوجه
+
+87
+00:07:34,960 --> 00:07:42,120
+فهنا و نسأل السؤال ال DNA viruses بتدخل المادة
+
+88
+00:07:42,120 --> 00:07:46,160
+الوراثية للنوكلياس و بيصير لها replication من خلال
+
+89
+00:07:46,160 --> 00:07:50,590
+مين؟الانزيمات بتاعة الفيروس ولا من خلال انزيمات
+
+90
+00:07:50,590 --> 00:07:57,230
+تبع ال ال host cell ال host cell طيب الفيروس اللي
+
+91
+00:07:57,230 --> 00:08:01,550
+مابيدخلش إلى النواة من ال DNA فيروس زي مثلا ال Vox
+
+92
+00:08:01,550 --> 00:08:05,670
+virus مضطر ايش يعمل لازم يجيب معاه الانزيمات تبع
+
+93
+00:08:05,670 --> 00:08:09,850
+هذه كمان نقطة ايضا يجب ان تبقى لا DNA in the
+
+94
+00:08:09,850 --> 00:08:12,990
+nucleus and viral capsimere proteins are made in
+
+95
+00:08:12,990 --> 00:08:17,580
+the cytoplasm from the messenger RNAالكانزاميرات
+
+96
+00:08:17,580 --> 00:08:22,220
+تدخل في النوكليا و الـ virions تجمع في نوكليا
+
+97
+00:08:22,220 --> 00:08:26,680
+الرئيسي بعد تجمعه الـ virions تتجمع في الصينوبلاسم
+
+98
+00:08:26,680 --> 00:08:33,120
+و تستعد لإخراجه من جسم الرئيسي بعض
+
+99
+00:08:33,120 --> 00:08:37,800
+الفيروسين لديها جينام رنة رقم واحد رقم رقم رقم رقم
+
+100
+00:08:37,800 --> 00:08:43,120
+رقم رقم رقم رقم رقم رقم رقم رقم رقم رقم رقم رقم
+
+101
+00:08:43,120 --> 00:08:43,920
+رقم رقم رقم رقم رقم رقم رقم رقم رقم رقم رقم رقم
+
+102
+00:08:43,920 --> 00:08:47,370
+رقم رقمThis messenger RNA is read by host
+
+103
+00:08:47,370 --> 00:08:51,170
+ribosomes to make viral proteins الكلام اللي
+
+104
+00:08:51,170 --> 00:08:56,990
+بيتحكى في هذه اللحظة هو ان ال mRNA أو عفوا البستف
+
+105
+00:08:56,990 --> 00:09:03,330
+since RNA virus genome can act as او directly can
+
+106
+00:09:03,330 --> 00:09:08,950
+act as a messenger RNA and can be translated
+
+107
+00:09:08,950 --> 00:09:09,990
+directly
+
+108
+00:09:13,250 --> 00:09:20,960
+الان السؤالإذا كان بيترانسليت Directly هل مطلوب من
+
+109
+00:09:20,960 --> 00:09:25,260
+إن الريبوزومات تبع الخلية الـ host cell تيجي على
+
+110
+00:09:25,260 --> 00:09:30,720
+هذه النسخة الأصلية و تقوم تشتغل عليها يبقى لازم ..
+
+111
+00:09:30,720 --> 00:09:35,820
+لازم .. لازم يجون نكون .. نكون template و ال
+
+112
+00:09:35,820 --> 00:09:40,500
+template هذا يعمل نسخ من ال genome اللي هو mRNA
+
+113
+00:09:40,500 --> 00:09:43,720
+صح؟ و يشتغل عليه اللي هو الريبوزومات
+
+114
+00:09:54,320 --> 00:09:57,560
+في مصطلح احنا ما .. ما .. ما .. مااتكلملناش فيه
+
+115
+00:09:57,560 --> 00:10:04,840
+قبل هيك لما يكون ال .. ال RNA مكون من positive و
+
+116
+00:10:04,840 --> 00:10:08,300
+negative strand بسمه ambience ambience يعني مكون
+
+117
+00:10:08,300 --> 00:10:12,280
+من positive strand و من اللي هو ال negative strand
+
+118
+00:10:35,830 --> 00:10:39,590
+وهي آخر رزق إن شاء الله في الـ viral replication
+
+119
+00:10:39,590 --> 00:10:46,560
+أعتقد توقفنا عند هذه اللوحةاللوحة هذه مهمة جدا
+
+120
+00:10:46,560 --> 00:10:49,500
+بتعطينا بعض الأفكار وبتلخصنا بعض المعلومات اللي
+
+121
+00:10:49,500 --> 00:10:54,500
+احنا ذكرناها عن ال RNA سابقا وانه انه من خصائص ال
+
+122
+00:10:54,500 --> 00:11:01,200
+viral mRNA انه بيمتلك ثلاث عوامل مشتركة مع ال
+
+123
+00:11:01,200 --> 00:11:03,020
+cellular mRNA
+
+124
+00:11:05,130 --> 00:11:09,230
+سفات مشتركة بين الـ Viral mRNA و بين الcellular
+
+125
+00:11:09,230 --> 00:11:13,370
+mRNA، ايش هذه السفات؟ رقم واحد بيقول إنه على الـ 5
+
+126
+00:11:13,370 --> 00:11:20,130
+prime end للـ mRNA، فينا methylated GDP cap، و هذا
+
+127
+00:11:20,130 --> 00:11:25,130
+موجود أيضا في مين؟ في ال mRNA تبع ال human و ال
+
+128
+00:11:25,130 --> 00:11:31,460
+host cellعلى ثلاثة prime في منطقة بنسميها tail او
+
+129
+00:11:31,460 --> 00:11:36,420
+ذيل مكون من مائة الى متين polyadenine برضه هذه
+
+130
+00:11:36,420 --> 00:11:40,660
+موجودة في من؟ في ال cells او الcellular معناه ايه؟
+
+131
+00:11:40,660 --> 00:11:47,010
+رقم تلاتة انمقدرة على إنه يحصل فينا splicing لل
+
+132
+00:11:47,010 --> 00:11:52,330
+mRNA من larger transcription أو transcribed يعني
+
+133
+00:11:52,330 --> 00:11:59,070
+بمعنى عندي mRNA طويل و قصدته إلى قطعة صغيرة وهذا
+
+134
+00:11:59,070 --> 00:12:03,310
+الكلام أيضا بيحدث فيان في الcellular mRNA إذا تلت
+
+135
+00:12:03,310 --> 00:12:08,230
+صفات مشتركةمع ال .. ال .. ال .. الcellular mRNA
+
+136
+00:12:08,230 --> 00:12:12,950
+رقم واحد ايش هي رقم واحد قلنا انه methylated GDP
+
+137
+00:12:12,950 --> 00:12:16,690
+cap رقم اتنين tail of one hundred to two hundred
+
+138
+00:12:16,690 --> 00:12:20,530
+قلنا عنهم adenosine residual او قلنا عنهم poly-A
+
+139
+00:12:20,530 --> 00:12:25,710
+رقم تلاتة انه فيه إمكانية انه نعمل قصلة اللي هو
+
+140
+00:12:25,710 --> 00:12:32,130
+small pieces من larger pieces mRNAالحقيقة انه لازم
+
+141
+00:12:32,130 --> 00:12:37,230
+كان نقول ان هي أوجه الشبه ما بين ال cellular mRNA
+
+142
+00:12:37,230 --> 00:12:42,450
+و ال viral mRNA عارفين ليش؟ لأن ال mRNA تم اكتشاف
+
+143
+00:12:42,450 --> 00:12:44,770
+هذه الصفات في تبع الفيروس قبل ما انا اكتشافها في
+
+144
+00:12:44,770 --> 00:12:49,950
+مين في ال cellular mRNA، إذن يعني في تشابه بين
+
+145
+00:12:49,950 --> 00:12:50,430
+اتنين
+
+146
+00:12:54,290 --> 00:12:57,870
+فاكرين لما قولنا ان بعض الفيروسات .. بعض الفيروسات
+
+147
+00:12:57,870 --> 00:13:03,330
+بتستغل الجينوم تبعها بال full capacity لما قولنا
+
+148
+00:13:03,330 --> 00:13:08,490
+ان قطعة صغيرة من الجينوم يمكن تغيير ال reading
+
+149
+00:13:08,490 --> 00:13:12,970
+frame يعني إذا عندي أنا sequence من القواعد قفزت
+
+150
+00:13:12,970 --> 00:13:17,210
+عن الأولى كل ال sequence اللي بعدها هيتغير وهذه
+
+151
+00:13:17,210 --> 00:13:24,430
+سياسة تخدم غرضين هيمر معانا كمان شوية ان كيفبننتج
+
+152
+00:13:24,430 --> 00:13:29,830
+one single mRNA that contains only one protein
+
+153
+00:13:29,830 --> 00:13:35,410
+يعني كوب تبعته لبروتين واحد بنفس القالية و هي
+
+154
+00:13:35,410 --> 00:13:40,730
+changing of reading frame بدا ما نبدأ في نقطة zero
+
+155
+00:13:40,730 --> 00:13:46,570
+نبدأ نقطة اتنين او تلاتة واحدة كدهwith some DNA
+
+156
+00:13:46,570 --> 00:13:49,510
+viruses there is a temporal control هاي صفة كمان
+
+157
+00:13:49,510 --> 00:13:54,770
+مهمة جدا كلمة temporal control معناها سيطرة زمانية
+
+158
+00:13:54,770 --> 00:14:02,770
+الآن لو احنا افترضنا التالي في ال early
+
+159
+00:14:02,770 --> 00:14:07,550
+transcription and translation كان في عندي فقط
+
+160
+00:14:07,550 --> 00:14:13,220
+transcription لأول جزء من الجينومفأول جزء من
+
+161
+00:14:13,220 --> 00:14:17,360
+الجينوم طلعت بروتينات على طول من أوله تعمل
+
+162
+00:14:17,360 --> 00:14:22,540
+Inhibition لل Transcription لل Late Genome او
+
+163
+00:14:22,540 --> 00:14:27,260
+لباقي الجينوم اش يعني؟ يعني طلعت Repressor Protein
+
+164
+00:14:27,260 --> 00:14:31,940
+.. ال Repressor Protein منع ال Transcription و ال
+
+165
+00:14:31,940 --> 00:14:35,820
+Translation لل Late Protein هذا ال protein اسمه
+
+166
+00:14:35,820 --> 00:14:38,700
+Repressor بيتدمر بعد ساعتين
+
+167
+00:14:41,260 --> 00:14:48,600
+يبقى أنا سيطرتعلى الجينات سيطراش زمانية بالضبط زي
+
+168
+00:14:48,600 --> 00:14:52,100
+ما واحد بيعمل ميقاتي لبدي بعت email بس مانتش
+
+169
+00:14:52,100 --> 00:14:54,960
+يبعتوا ال email لان بدي بعت ال email بعدها بعد
+
+170
+00:14:54,960 --> 00:14:59,720
+ساعتين طب اروح بحط شرط انه ت send after two hours
+
+171
+00:14:59,720 --> 00:15:04,260
+او زي القنبلة بحطها توقيت انه تنفجر مثلا بعد نص
+
+172
+00:15:04,260 --> 00:15:08,920
+ساعة او ساعة فإذا هذا ال protein وكأنه توقيت
+
+173
+00:15:08,920 --> 00:15:16,070
+للعملية الأخرى ايش العملية الأخرى؟بدأ .. بدأ ال
+
+174
+00:15:16,070 --> 00:15:18,090
+transcription لأن هو اللي كان مانع ال
+
+175
+00:15:18,090 --> 00:15:21,070
+transcription بعد ما خلصت الفترة الزمنية صار فيه
+
+176
+00:15:21,070 --> 00:15:25,030
+أنه وهذه العملية الحقيقة غريبة جدا في الفيروسات
+
+177
+00:15:25,030 --> 00:15:28,690
+أنه عندها المقدرة على إنها تعمل temporal control
+
+178
+00:15:28,690 --> 00:15:29,870
+لبعض الجينة
+
+179
+00:15:38,120 --> 00:15:44,780
+الـ Monocistronic RNA تعريفه هو الـ RNA التي
+
+180
+00:15:44,780 --> 00:15:49,680
+تتعامل مع واحد من البروتين، بينما الـ
+
+181
+00:15:49,680 --> 00:15:50,520
+Polycistronic
+
+182
+00:15:52,880 --> 00:15:59,600
+أكيد يعني فكيف هي العمليات التي من خلالها تنتج
+
+183
+00:15:59,600 --> 00:16:04,140
+الفيروسات one single mRNA او one single protein
+
+184
+00:16:04,140 --> 00:16:08,620
+from mRNA طبعا واحدة منهم درسناها بتفصيل المرة
+
+185
+00:16:08,620 --> 00:16:11,440
+الماضية الأخيرة اللي يعني هنا مثلا ال poly virus
+
+186
+00:16:11,440 --> 00:16:17,640
+كنا بينتج transcription ل ال mRNA واحد و
+
+187
+00:16:17,640 --> 00:16:23,900
+translation واحد فبسميه polyببتاعت أو سمنها
+
+188
+00:16:23,900 --> 00:16:27,300
+precursor poly-beptide اللي هو ال poly-beptide
+
+189
+00:16:27,300 --> 00:16:31,700
+الطويل اللي مثلناه بقطعات خشب تمام غير مؤهلة لإنها
+
+190
+00:16:31,700 --> 00:16:36,240
+تكون لا قاعدة ولا أدراج ولا غيره لكن بعد ما
+
+191
+00:16:36,240 --> 00:16:39,980
+أنتجناها استطعنا من خلال الانزيم انه نقطعها إلى
+
+192
+00:16:39,980 --> 00:16:45,290
+قطع صغيرفي فيروسات تانية زي مثلا الريو فيروس
+
+193
+00:16:45,290 --> 00:16:47,490
+والإنفلوانزا فيروس زي ما أحنا شايفين على اللوحة
+
+194
+00:16:47,490 --> 00:16:51,170
+هنا الريو فيروس والإنفلوانزا فيروس أصلا ال genome
+
+195
+00:16:51,170 --> 00:16:55,870
+تبعهم مقطع واحد تمام قطعة وواحد عشر قطعة فكل قطعة
+
+196
+00:16:55,870 --> 00:17:00,490
+أصلا can encode for single polypeptide أو single
+
+197
+00:17:00,490 --> 00:17:05,120
+proteinطبعا الأولى اللى احنا حاكيناها هي starting
+
+198
+00:17:05,120 --> 00:17:09,860
+at different reading frames انه نبدأ القراها من
+
+199
+00:17:09,860 --> 00:17:14,260
+نقاط مختلفة على الجينو، إذا هذه الثلاث ميكانيزمات
+
+200
+00:17:14,260 --> 00:17:20,660
+by which viruses can produce mono-cystronic mRNA
+
+201
+00:17:20,660 --> 00:17:27,100
+من polycystronic جينوالمفهوم الأخير اللي هنقشه في
+
+202
+00:17:27,100 --> 00:17:31,460
+محاضرة اليوم وفي ال replication بشكل عام مفهوم ال
+
+203
+00:17:31,460 --> 00:17:34,840
+isogenic وهذا المفهوم الحقيقة مار معانا في ال
+
+204
+00:17:34,840 --> 00:17:37,420
+essential medical microbiology ومار معانا في ال
+
+205
+00:17:37,420 --> 00:17:41,960
+diagnostic لكن مكانه الصحيح هنا في ال virology
+
+206
+00:17:41,960 --> 00:17:49,630
+لذلك سنحاول أن نقشه بعمق أكتر بإذن اللهنحن نعلم أن
+
+207
+00:17:49,630 --> 00:17:54,870
+ال cycle التي شرحناها و أظهرناها في أكثر من مناسبة
+
+208
+00:17:54,870 --> 00:17:58,790
+في ال presentations تبعتنا هي أن الفيروس يدخل إلى
+
+209
+00:17:58,790 --> 00:18:04,770
+داخل الخلية و من ثم ينتج فيروسات و يخرج إلى الخارج
+
+210
+00:18:04,770 --> 00:18:08,970
+بكل سلاسة و سهولة و يدخل واحد و يطلع مئات
+
+211
+00:18:08,970 --> 00:18:14,760
+الفيروساتهذه بنسميها Lytic Cycle والفيروسات
+
+212
+00:18:14,760 --> 00:18:19,740
+بنسميها Lytic Viruses Lytic من ايه؟ من عملية
+
+213
+00:18:19,740 --> 00:18:27,420
+التحلل في عملية اسمها Lysogenic مش Lytic بتختلف
+
+214
+00:18:27,420 --> 00:18:33,060
+تماما في مرحلة من المراحل و بتتشابه تماما في مرحلة
+
+215
+00:18:33,060 --> 00:18:38,370
+من المراحل مع من؟ مع ال Lytic Virusesإيش برج
+
+216
+00:18:38,370 --> 00:18:43,390
+الإختلاف؟ الميروس هنا في الريسوجيني لما بيدخل
+
+217
+00:18:43,390 --> 00:18:50,870
+بيدخل إلى داخل الخلية ولا يحدث ضرروإنما يطلب من ال
+
+218
+00:18:50,870 --> 00:18:56,270
+chromosome تبع الخلية بأن يدمج داخلها فبصير فيه
+
+219
+00:18:56,270 --> 00:19:00,950
+نوع من الاتحاد ما بين الفيروس وما بين اللي هو ال
+
+220
+00:19:00,950 --> 00:19:04,990
+genome تبع ال host cell وأن نفترض أنه بكتيريا لأن
+
+221
+00:19:04,990 --> 00:19:08,930
+أكتر حاجة مفهومة لنا في ال life journey هي ال
+
+222
+00:19:08,930 --> 00:19:15,390
+viruses مع من؟ مع البكتيريا طيب البكتيريا
+
+223
+00:19:17,860 --> 00:19:23,920
+أيش هتستفيد من وجود Viral Genome داخلها؟ والفيروس
+
+224
+00:19:23,920 --> 00:19:28,960
+أيش هيستفيد من وجوده داخل البكتيريا؟ ناخد الجانب
+
+225
+00:19:28,960 --> 00:19:32,910
+تبع مين؟ بتاع الفيروس بالأولعندما تنقسم البكتيريا
+
+226
+00:19:32,910 --> 00:19:37,810
+أكيد تنقسم وينقسم الكروموزوم تبعها بالكامل اللي من
+
+227
+00:19:37,810 --> 00:19:43,170
+ضمنه مين؟ الفيروس، إذا كل انقسام للبكتيريا، يعني
+
+228
+00:19:43,170 --> 00:19:45,970
+انقسام بصيره اتنين، اربع، تمانين، ستاشر، اتنين و
+
+229
+00:19:45,970 --> 00:19:50,290
+تلاتين يبقى مع كل نسخة جديدة من البكتيريا بيطلع
+
+230
+00:19:50,290 --> 00:19:54,950
+نسخة من مين؟ من الفيروس، إذا هو مرتاح، ماعنده
+
+231
+00:19:54,950 --> 00:19:58,230
+مشاكل، مش هو اللي بيشتغل، البكتيريا اللي بتشتغل،
+
+232
+00:19:58,230 --> 00:20:02,450
+بتنقسم و هو بيتكاثريعني لو خلال عشر ساعات ممكن
+
+233
+00:20:02,450 --> 00:20:07,570
+يصير هو عنده مليار نسخة واتفاقيته مع البكتيريا
+
+234
+00:20:07,570 --> 00:20:13,290
+اتفاقية مؤقتة الحلوة بس المرة لأ لما بتكون الأمور
+
+235
+00:20:13,290 --> 00:20:19,250
+سالسة و البكتيريا بتتغذى و بتتكاثر هو بيضلوا ضمن
+
+236
+00:20:19,250 --> 00:20:24,930
+التحالف عندما يستشعر أن هناك خطر على البكتيريا قد
+
+237
+00:20:24,930 --> 00:20:29,720
+تموت مثلا تعارض ل ultra violet lightبيروح بيفصل
+
+238
+00:20:29,720 --> 00:20:36,020
+نفسه من مين؟ من ال genome تبع البكتيريا و بيبدأ
+
+239
+00:20:36,020 --> 00:20:42,440
+شغل أخوه اللي اسمه Lytic virusوبيحلل البكتيريا
+
+240
+00:20:42,440 --> 00:20:48,860
+وتخيلوا هو الآن ضمن مليار خلية ومن كل خلية بيطلع
+
+241
+00:20:48,860 --> 00:20:52,800
+زي ابن عمه مئات ال bacteriophages فهذا
+
+242
+00:20:52,800 --> 00:20:57,380
+الاستراتيجية استراتيجية ناجحة لكثير من الفيروسات
+
+243
+00:20:57,380 --> 00:21:01,690
+طيب what's in it for the bacteria؟أخدنا الجانب
+
+244
+00:21:01,690 --> 00:21:06,850
+المشرق للفيروس طب ما الجانب المشرق للبكتيريا؟ لكم
+
+245
+00:21:06,850 --> 00:21:09,870
+أن تتخيلوا بكتيريا بتعرفوها كل كوسمها
+
+246
+00:21:09,870 --> 00:21:14,270
+streptococcus biogenes اللي بتسبب لنا tonsillitis
+
+247
+00:21:14,270 --> 00:21:20,450
+لكم أن تتخيلوا أن فيروس اجى وعمل فيها العمل اللي
+
+248
+00:21:20,450 --> 00:21:23,390
+شفتوها اللي هي ال isogenic ايش العمل هذه؟ دخل
+
+249
+00:21:23,390 --> 00:21:28,290
+الجينوم تبعه في الجينوم تبع هذه البكتيرياو أعطاها
+
+250
+00:21:28,290 --> 00:21:32,390
+قدرة يبقى بعض الفيروسات لما بتعمل ال isogenic
+
+251
+00:21:32,390 --> 00:21:36,270
+بتعطي البكتيريا قدرة على إنتاج حاجة إيش الحاجة
+
+252
+00:21:36,270 --> 00:21:40,710
+اللي إنتجتها البكتيريا هذه و خلتها شهيرة كمية
+
+253
+00:21:40,710 --> 00:21:44,390
+كبيرة من ال proteases يبقى الفيروس جابلها gene
+
+254
+00:21:44,390 --> 00:21:48,810
+جديد بيعطي كميات ضخمة من مين؟ من إنزيمات ال
+
+255
+00:21:48,810 --> 00:21:54,790
+proteases الآن هذه الانزيمات جعلت البكتيريا شريها
+
+256
+00:21:54,790 --> 00:22:00,290
+جدا لللحمفلو عملت إلنا التهاب في جروح مثلا في
+
+257
+00:22:00,290 --> 00:22:05,390
+الكتف، تاني يوم العضم بيبين، ليش؟ لأن البكتيريا
+
+258
+00:22:05,390 --> 00:22:08,910
+صارت تنتج كمية كبيرة من البروتياز، فأصبح لديها
+
+259
+00:22:08,910 --> 00:22:12,150
+المقدر على هضم البروتينات اللي هي ال muscle
+
+260
+00:22:12,150 --> 00:22:16,270
+سبعتنا، فبالتالي سموها flesh eating bacteria،
+
+261
+00:22:16,270 --> 00:22:22,320
+بكتيريا آكلت اللحمةوالسبب هي بريئة، من المجرم؟
+
+262
+00:22:22,320 --> 00:22:25,480
+البكتيريا، فهذه اللي أعطانا هذه القدرة، فبقى هذه
+
+263
+00:22:25,480 --> 00:22:28,360
+الكلام ليس حالة فريدة يا بنات في ال .. في ال
+
+264
+00:22:28,360 --> 00:22:30,800
+microbiology، اتطلعوا على اللوحة اللي جداننا هنا
+
+265
+00:22:32,500 --> 00:22:36,160
+الـ Diphtheria لم تكن سامة إلا من خلال الـ
+
+266
+00:22:36,160 --> 00:22:40,000
+Bacteriophage، البوتلونيوم السم الأقوى على وجه
+
+267
+00:22:40,000 --> 00:22:43,700
+الأرض، السم البيولوجي الأقوى، برضه ناتج عن الـ
+
+268
+00:22:43,700 --> 00:22:47,000
+Bacteriophage، الكوليرة اللي الآن منتشرة في
+
+269
+00:22:47,000 --> 00:22:50,140
+أخواننا في اليمن ورزقه من العراق ويمكن في سوريا
+
+270
+00:22:50,140 --> 00:22:54,680
+مؤكد موجودة في سوريا، لكن الأخبار لاتصل إلا على
+
+271
+00:22:54,680 --> 00:22:59,860
+عدد القتلىالكلراتوكسين والإيريثروجينيك توكسين كلها
+
+272
+00:22:59,860 --> 00:23:07,240
+توكسين مجموعة من بكتيريو فاجز اللي بتعمل ليسو جيني
+
+273
+00:23:07,240 --> 00:23:11,400
+إذا في هناك فوائد لمن؟ للبكتيريا إنها بصي تمتلك
+
+274
+00:23:11,400 --> 00:23:15,860
+قدرات بتأهلها إنها تكون more virulent وبالتالي
+
+275
+00:23:15,860 --> 00:23:21,020
+تعمل disease للإنسان العملية عشان أنا ماتطولش
+
+276
+00:23:21,020 --> 00:23:25,320
+عليكم فيها بدي أحاول أنه ألخصلكوا إياها تمثليا
+
+277
+00:23:25,320 --> 00:23:30,020
+بالإدانةالـ viruses اللي بتعمل الـ lysogeny غالبا
+
+278
+00:23:30,020 --> 00:23:37,540
+بتكون DNA viruses و linear فبيدخل المادة الوراثية
+
+279
+00:23:37,540 --> 00:23:44,080
+إلى الخلية ك linear DNA قبل ما يصير في integration
+
+280
+00:23:44,080 --> 00:23:49,880
+مش انها integration دمج دمج يعني جعل اتنين واحد
+
+281
+00:23:49,880 --> 00:23:54,700
+لازم يصير حاجة اسمها الcirculation يعني ال linear
+
+282
+00:23:54,700 --> 00:24:00,670
+يتكون و يصير دائرةكيف ممكن لينيار دوبل استران يصير
+
+283
+00:24:00,670 --> 00:24:05,790
+دائرة إذا تخيلنا إن الطرفين تبعونه واحد من هنا
+
+284
+00:24:05,790 --> 00:24:10,530
+واحد من هنا فالتين أكمن base pair مش double
+
+285
+00:24:10,530 --> 00:24:14,830
+strand، single strand؟فلما بلفناهم على بعض هذه
+
+286
+00:24:14,830 --> 00:24:18,610
+بتكمل هذه ب let's go مع بعض بس ال .. بس اللصق هذا
+
+287
+00:24:18,610 --> 00:24:23,410
+بيحتاج إيش يا بنات؟ بيحتاج ligating enzyme،
+
+288
+00:24:23,410 --> 00:24:28,010
+ligating enzyme وهذا ممكن ال virus يجيبه معاه
+
+289
+00:24:28,010 --> 00:24:33,310
+وبالتالي يسهل العملين، الأن صار عندي circle،
+
+290
+00:24:33,310 --> 00:24:36,650
+اليمين ال circle هذي، الكرموزام، تبع مين؟
+
+291
+00:24:43,840 --> 00:24:52,060
+هذا بيبحث عن homologous ساعة 2 في البكتيريا وعن
+
+292
+00:24:52,060 --> 00:24:55,920
+طريق بعض الإنزيمات برضه بيعمل حتة اسمة breaking
+
+293
+00:24:56,890 --> 00:25:00,250
+البريكيكاليب بجُص هنا وبجُص هنا وبعدين بيصير في
+
+294
+00:25:00,250 --> 00:25:06,270
+عندنا rejoining فبصير عندي DNA جزء منه فيروس وجزء
+
+295
+00:25:06,270 --> 00:25:12,370
+منه مين اللي هو البكتيري وهذا ال integration وبعض
+
+296
+00:25:12,370 --> 00:25:16,650
+الفيروسات ال animal viruses زي ال tumor viruses و
+
+297
+00:25:16,650 --> 00:25:21,510
+الherpes viruses بتعمل integrationفي الـ human
+
+298
+00:25:21,510 --> 00:25:27,310
+genome، إذا ليس فقط البكتيريو فاجز وانما بعض ال
+
+299
+00:25:27,310 --> 00:25:30,850
+human viruses زي ال tumor viruses و ال herpes
+
+300
+00:25:30,850 --> 00:25:37,530
+virus طبعا و هندرس كمان ال HIV لاحقا هذا جزء من ال
+
+301
+00:25:37,530 --> 00:25:42,890
+life cycle لازم يعمل integration لل genome تبعه في
+
+302
+00:25:42,890 --> 00:25:49,230
+our host DNA، تمام؟لذلك .. لذلك ال .. ال HIV من
+
+303
+00:25:49,230 --> 00:25:53,750
+المرشحات .. من المرشحات لل gene therapy ليش ال
+
+304
+00:25:53,750 --> 00:25:59,270
+gene therapy؟ مدان بيعمل integration تمام؟ يبقى
+
+305
+00:25:59,270 --> 00:26:02,910
+أنا خلينا أشيل الجينات السيئة اللي فيه اللي بتعمل
+
+306
+00:26:02,910 --> 00:26:06,670
+لمرض و أخلي الجينات اللي بتعمل ال integration و
+
+307
+00:26:06,670 --> 00:26:10,750
+أضيف عليها الجينات اللي أنا بدي أصلحها في الشخص
+
+308
+00:26:10,750 --> 00:26:14,910
+المصاب بمرض و يبعدها على سبيل المثالفبنضمن ان
+
+309
+00:26:14,910 --> 00:26:24,210
+الفيروس هيدخل جوا الخلية وهيبقى هناك مع الجينات
+
+310
+00:26:24,210 --> 00:26:28,150
+السليمة اللي انا بده انقلها لهذا الانسان نرجع مرة
+
+311
+00:26:28,150 --> 00:26:29,830
+تانية عملنا ايش قلنا؟
+
+312
+00:26:34,790 --> 00:26:39,170
+Integration من خلال breakage and rejoining اللي هي
+
+313
+00:26:39,170 --> 00:26:43,990
+القص و يعادة اللي هو الالتصاق الفيروس لما بيكون في
+
+314
+00:26:43,990 --> 00:26:47,790
+هذه الحالة موجود داخل الخلية مش بنسميه بروفاج
+
+315
+00:26:47,790 --> 00:26:53,030
+الخلية المصابة بالفيروس بنسميها lysogenized cell
+
+316
+00:26:53,030 --> 00:26:56,530
+يبقى الفيبرو كلها اللي تنتج الكوليراتكسين هي عبارة
+
+317
+00:26:56,530 --> 00:27:00,010
+عن ايه ال lysogenized cell ال clostridium
+
+318
+00:27:00,010 --> 00:27:03,730
+botulinumاللي بتنتج بوتلونيوم توكسين يبقى هي
+
+319
+00:27:03,730 --> 00:27:10,270
+رايسجينوز سيل وداخلها بروفعيش البروفعيش قلنا عنه
+
+320
+00:27:10,270 --> 00:27:15,490
+not permanently integrated لو شعرو في المعمل على
+
+321
+00:27:15,490 --> 00:27:18,850
+فكرة هتخليه شعار من خلال تعرض البكتيريا ل
+
+322
+00:27:18,850 --> 00:27:22,010
+ultraviolet light مجرد أنه هتتعرض البكتيريا ل
+
+323
+00:27:22,010 --> 00:27:26,690
+ultraviolet light بيرجع و بيفصل نفسه و بيكمل ال
+
+324
+00:27:26,690 --> 00:27:29,550
+cycle بتاعة ال lightic phase إذا مافيه اندي
+
+325
+00:27:29,550 --> 00:27:36,750
+lightic و lysogenic cycle طيب اللوحة اللي أمامنا
+
+326
+00:27:36,750 --> 00:27:43,030
+بتوضح لنا طريقين لأي فيروس في الدنيا الفيروس هيته
+
+327
+00:27:43,030 --> 00:27:49,800
+على الطرفهنا التسخ بالخلية البكتيرية او اعفن
+
+328
+00:27:49,800 --> 00:27:54,860
+بالخلية بشكل عام ال host cell وعمل ادراج للمادة
+
+329
+00:27:54,860 --> 00:27:59,880
+الوراثية او دخله داخل الخلية تفهم دي طريق ال Lytic
+
+330
+00:27:59,880 --> 00:28:07,200
+cycle انه يكوّن جوا ال host cell فيروسات من نسله
+
+331
+00:28:07,200 --> 00:28:11,240
+بروجيني فيروس ويعملها لايسز و يطلع عشان تسميها ال
+
+332
+00:28:11,240 --> 00:28:16,700
+cycle اللي قلناهاأو الطريق الآخر طبعا هذا مش خيار
+
+333
+00:28:16,700 --> 00:28:21,840
+خدوا بألكوا هى طبيعة في الفيروسات يعنى فى لاتك
+
+334
+00:28:21,840 --> 00:28:25,860
+فيروس وفى لايسوجينك فيروس فى اللايسوجينك فيروس
+
+335
+00:28:25,860 --> 00:28:30,600
+لحظوا الخط المدرج هذا هو عبارة عن ايه؟ ايش يعني ال
+
+336
+00:28:30,600 --> 00:28:35,420
+proofage؟ ال proofage هو ال genome تبع ال virus
+
+337
+00:28:35,420 --> 00:28:40,260
+اللى هو صارله integration فى ال host cellلو صار له
+
+338
+00:28:40,260 --> 00:28:45,180
+UV طبعا خدوا بالك في اللحظة هذه الفيروس مبسوط وكل
+
+339
+00:28:45,180 --> 00:28:49,940
+ما انقسمت الخلية بينقسم معاه لو صار فيه ضرر على
+
+340
+00:28:49,940 --> 00:28:55,150
+الخلية و احنا بنقول ال UV مثاللكن هناك أمثلة عديدة
+
+341
+00:28:55,150 --> 00:28:59,910
+مثلا فيش نوترينت مافيه نوترينت ارتفاع حرارة انخفاض
+
+342
+00:28:59,910 --> 00:29:04,710
+حرارة toxic material antibiotic شعر الفيروس بإن
+
+343
+00:29:04,710 --> 00:29:10,550
+البكتيريا مهددة بالخطر أو إن حياتها في خطر فهو
+
+344
+00:29:10,550 --> 00:29:14,530
+بقولك عم هي تموت أنا مالي تمام؟ أنا بفصل نفسي و
+
+345
+00:29:14,530 --> 00:29:19,640
+بتكاتر مرة أخرى علشان نروح على خلايالذلك يا بنات
+
+346
+00:29:19,640 --> 00:29:23,440
+أنجح مخلوقات على كوكب الأرض بالكمين الانسان ولا
+
+347
+00:29:23,440 --> 00:29:28,960
+الديناصولات؟ الفيروسات وهي الأكثر عالدا بالمناسبة
+
+348
+00:29:28,960 --> 00:29:35,420
+ولو يعني في مقاربة لطيفة انه لو على رغم من صغرها
+
+349
+00:29:35,420 --> 00:29:41,560
+لو جمعناها الفيروسات تمام يمكن الوزن تبعها يوازي
+
+350
+00:29:41,560 --> 00:29:44,520
+وزن البشر الموجودين على كوكب الأرض، إيش رأيكم؟
+
+351
+00:29:45,150 --> 00:29:49,270
+فالفيروسات مخلوقات ناجحة لديها المقدرة على التكاثر
+
+352
+00:29:49,270 --> 00:29:51,910
+بشكل فعال في ال host cell
+
+353
+00:29:55,260 --> 00:29:59,340
+طيب كتفصيل اكتر للعمري اللي احنا ذكرناها احنا
+
+354
+00:29:59,340 --> 00:30:03,600
+ذكرنا انه ال .. الفاج بيعمل injection للمادة
+
+355
+00:30:03,600 --> 00:30:08,260
+الوراثية تمام؟ وهي linear شايفينها؟ خطية صارلها
+
+356
+00:30:08,260 --> 00:30:12,620
+ايش الآن؟ circleization بعدين اللي هو ال breakage
+
+357
+00:30:12,620 --> 00:30:16,180
+and rejoining وبعدين اللي هو ال integration اللي
+
+358
+00:30:16,180 --> 00:30:20,540
+بتصير انها جونا ال proofage وقد يحصل لها بعد ذلك
+
+359
+00:30:20,540 --> 00:30:26,720
+جونا انفصال مرة اخرىطب نستغل المعلومة اللي قمنا من
+
+360
+00:30:26,720 --> 00:30:32,080
+هنا في حد اسمها Transduction درسناها ساجقا، ال
+
+361
+00:30:32,080 --> 00:30:36,180
+Transduction هو عبارة عن ايش Transduction؟ نقل ..
+
+362
+00:30:36,180 --> 00:30:39,880
+وسيلة نقل جينات من خلال مين برضه؟ من خلال ال
+
+363
+00:30:39,880 --> 00:30:44,940
+virusات، و احنا درسنا على فكرة التنين، درسناالريتك
+
+364
+00:30:44,940 --> 00:30:47,440
+والليسوجينيك وهقولكوا كيف ده راسنهم ده راسنهم
+
+365
+00:30:47,440 --> 00:30:50,780
+باسمين مختلفين generalized transduction
+
+366
+00:30:50,780 --> 00:30:55,560
+وspecialized transduction تخيلوا لما انا قلت قبل
+
+367
+00:30:55,560 --> 00:31:03,040
+بشوية انه دائما الفيروس بيبحث عن نقطة للدخول الى
+
+368
+00:31:03,040 --> 00:31:08,900
+الجينوم كلمة نقطة ويبحث بجهة specific point الان
+
+369
+00:31:08,900 --> 00:31:13,380
+الفيروس هذا هو طالعلما بدي .. بدي انسخ نفسه من ال
+
+370
+00:31:13,380 --> 00:31:17,060
+.. ال .. المادة اللي وراها فيها، بينسخ نفسه و
+
+371
+00:31:17,060 --> 00:31:23,720
+بياخد قطعة معاه من مين؟ من ال host DNA لما بياخد
+
+372
+00:31:23,720 --> 00:31:28,300
+host DNA قطعة، ده باخدها من وين؟ من جنبه، باخداش
+
+373
+00:31:28,300 --> 00:31:32,020
+من مكان بعيد، طبعا .. طبعا باخدها من جنبه، و كل
+
+374
+00:31:32,020 --> 00:31:35,740
+مرة بيدخل أصلا من نفس المكان، يبقى كل مرة بدياخد
+
+375
+00:31:35,740 --> 00:31:40,400
+نفس مين؟ نفس القطعةهنكسب منها specialized
+
+376
+00:31:40,400 --> 00:31:45,880
+transduction لأنه بياخد دائما من the same piece of
+
+377
+00:31:45,880 --> 00:31:50,900
+DNAفي ال .. في ال .. في ال .. في ال generalized
+
+378
+00:31:50,900 --> 00:31:57,440
+transduction كان هناك عملية license و ال license
+
+379
+00:31:57,440 --> 00:32:03,720
+للخلية بدمر ال DNA تبعها فحلاجي viral genome و
+
+380
+00:32:03,720 --> 00:32:09,280
+حلاجي host genome او DNA اذا تشابهت قطعة في الحجم
+
+381
+00:32:09,280 --> 00:32:14,480
+قد يحصل بعض .. يحصل بعض الفيروسات او ال .. ال
+
+382
+00:32:14,480 --> 00:32:21,710
+capsids قد تعبق بمين؟ ب hostgenome او DNA فالان اي
+
+383
+00:32:21,710 --> 00:32:25,710
+قطعة من ال genome قد تدخل الى هذا ال virus كلمة اي
+
+384
+00:32:25,710 --> 00:32:31,030
+قطعة مش زي كل مرة نفس القطعة يبقى هذا generalized
+
+385
+00:32:31,030 --> 00:32:35,790
+وهذا اشماله وهذا specialized, trans,duction وهذا
+
+386
+00:32:35,790 --> 00:32:43,430
+كمان مرة احد اهم وسائل نقل المعلومات بين البكتيريا
+
+387
+00:32:43,430 --> 00:32:44,970
+والبكتيريا الاخرى
+
+388
+00:32:48,210 --> 00:32:54,010
+النقطة أو التلميح الأخير في المحاضرة اللي هو عملية
+
+389
+00:32:54,010 --> 00:32:57,970
+حصول
+
+390
+00:32:57,970 --> 00:33:04,970
+صفات معينة بدخول الـ bacterophage إلى البكتيريا،
+
+391
+00:33:04,970 --> 00:33:07,510
+مثلا هذا ال bacterophage اللي مسمى beta phage
+
+392
+00:33:07,970 --> 00:33:12,550
+بيحتوى على مين؟ على الـ Diphtheria توكسين جين دخلت
+
+393
+00:33:12,550 --> 00:33:17,270
+إلى البكتيريا الكروموزوم و أصبحت ضمن مين الآن؟ ضمن
+
+394
+00:33:17,270 --> 00:33:21,290
+البكتيريا لأن بدأت أصبحت ضمن البكتيريا والبكتيريا
+
+395
+00:33:21,290 --> 00:33:25,960
+أمورها تمام مافي مشكلة بتتكاتروبتنقسم وبتنتج هذا
+
+396
+00:33:25,960 --> 00:33:31,080
+التكسين الذي من شأنه إيقاف تصنيع لبروتين في خلايا
+
+397
+00:33:31,080 --> 00:33:33,940
+ال host ومن ثم إحداث المرض الخطير اللي اسمه
+
+398
+00:33:33,940 --> 00:33:38,500
+diphtheria واصلا ال vaccine اللي عملنا على ال
+
+399
+00:33:38,500 --> 00:33:43,090
+diphtheria عارفين مين موجهه؟موجه للتوكسين اللى
+
+400
+00:33:43,090 --> 00:33:47,210
+بتنتجه الـ diphtheria، وهذا التوكسين أصلا هو مش من
+
+401
+00:33:47,210 --> 00:33:51,730
+صنع من البكتيريا نفسها وإنها من صنع البكتيريوفاج
+
+402
+00:33:51,730 --> 00:33:54,950
+اللى هو موجود فيها، والمرة الجاية ان شاء الله نكمل
+
+403
+00:33:54,950 --> 00:33:56,350
+بموضوع جديد
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA.srt
new file mode 100644
index 0000000000000000000000000000000000000000..19feefb5593f6ecf9917f645757c8a8c527d9f80
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA.srt
@@ -0,0 +1,2175 @@
+1
+00:00:20,870 --> 00:00:22,790
+بسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:22,790 --> 00:00:26,370
+الصلاة والسلام على سيدنا محمد وعلى آله وصحبه ومن 
+
+3
+00:00:26,370 --> 00:00:30,570
+ساعده ربيع الأعمال الدين كل عام وأنتم بخير بمناسبة 
+
+4
+00:00:30,570 --> 00:00:33,690
+بدء الفصل الدراسي الجديد وإن شاء الله يكون عام خير 
+
+5
+00:00:33,690 --> 00:00:38,950
+وجد واجتهاد ونجاح بإذن الله مصاق اللي هندرسه مع 
+
+6
+00:00:38,950 --> 00:00:42,280
+بعض إن شاء الله اليوم اللي هو الـ biology والحقيقة
+
+7
+00:00:42,280 --> 00:00:46,940
+أنكم محظوظين أنكم درستم essential و medical
+
+8
+00:00:46,940 --> 00:00:50,520
+microbiology سابقا لهذا الـ course لأنه كثير من 
+
+9
+00:00:50,520 --> 00:00:54,400
+المعلومات المذكورة في هذا المصاد ستجدون أنكم 
+
+10
+00:00:54,400 --> 00:01:00,610
+بتعرفوها مسبقا إن شاء الله قبل ما أبدأ بعرض مفارضات 
+
+11
+00:01:00,610 --> 00:01:07,230
+المساق بنحاول نشوف اللي هو course outline أو الـ
+
+12
+00:01:07,230 --> 00:01:12,030
+course syllabus طبعا بتعرفوني عبدالروف المنعمة 
+
+13
+00:01:12,030 --> 00:01:19,860
+مدرسكم السابق للمساق اسمه virology والعدد الساعات 
+
+14
+00:01:19,860 --> 00:01:24,220
+المعتمدة هو ثلاث ساعات فقط لغير الـ course number
+
+15
+00:01:24,220 --> 00:01:30,980
+ميدي تلاتة تلاتة خمسة أربع الساعات اللي بنلتقي 
+
+16
+00:01:30,980 --> 00:01:34,160
+فيها إن شاء الله هي من التاسعة إلى العشرة سبت 
+
+17
+00:01:34,160 --> 00:01:37,860
+اثنين أربعاء في هذه القاعة اللي هي الآن M601
+
+18
+00:01:39,840 --> 00:01:43,760
+الـ website الخاص بيه أنا برضه بتعرفوه موجود على 
+
+19
+00:01:43,760 --> 00:01:46,620
+المحاضرة إن شاء الله الـ email تبعي أنا وبفضل 
+
+20
+00:01:46,620 --> 00:01:50,220
+وسيلة التواصل أما على الـ facebook أو على الـ email
+
+21
+00:01:50,220 --> 00:01:54,540
+يعني أكثر من هاتف أو زيارة حتى المكتب مع أنه 
+
+22
+00:01:54,540 --> 00:01:58,780
+هتخصكم إن شاء الله ساعات مكتبية بالنسبة لي اللي هي 
+
+23
+00:01:58,780 --> 00:02:03,500
+الغالبا بعد المحاضرة من الـ 11 من العشرة الـ 11 سبت 
+
+24
+00:02:03,500 --> 00:02:06,080
+اثنين أربع ساعات مكتبية بتكونوا فاضين فيها ولا 
+
+25
+00:02:06,080 --> 00:02:13,470
+مشغولين؟ مشغولين؟ من الـ 11 لـ 12 برضه فرق خلاص ممكن 
+
+26
+00:02:13,470 --> 00:02:18,790
+نمدها من العشرة لـ 12 إن شاء الله العشرة لـ 12 طبعا 
+
+27
+00:02:18,790 --> 00:02:23,910
+المكتب يقنع الجديد في الطابق الثالث في مبنى العلوم 
+
+28
+00:02:23,910 --> 00:02:28,210
+الطبية المخبرية في قسم التخصصات الطبية يعني بقرب من 
+
+29
+00:02:28,210 --> 00:02:32,730
+مكاتب الأساتذة في القسم إن شاء الله بالنسبة للـ
+
+30
+00:02:32,730 --> 00:02:37,570
+facebook group مننا group لكم اسمها Virology 201،
+
+31
+00:02:37,570 --> 00:02:42,250
+201 على رقم الشعب اللي أنتو تسجلون فيها، لو فت...
+
+32
+00:02:42,250 --> 00:02:45,650
+لو فتحتوا عليها اليوم إن شاء الله وعملتوا انضمام، 
+
+33
+00:02:45,650 --> 00:02:49,050
+طلب انضمام، هتلاقوا المحاضرة اللي معانا الآن 
+
+34
+00:02:49,050 --> 00:02:51,570
+موجودة والـ course outline أو الـ course syllabus
+
+35
+00:02:51,570 --> 00:02:56,760
+أيضا هتلاقوه إن شاء الله موجود بالنسبة للكتاب هو 
+
+36
+00:02:56,760 --> 00:03:00,220
+كتاب عالم مشهور اسمه a review of medical 
+
+37
+00:03:00,220 --> 00:03:05,160
+microbiology and immunology والـ .. الـ .. حيكون 
+
+38
+00:03:05,160 --> 00:03:10,320
+ضمن المساق إن شاء الله flashات وصور وفيديوهات 
+
+39
+00:03:10,320 --> 00:03:14,040
+إن شاء الله هنزودكم فيها أو روابط لها حتى تحضروها
+
+40
+00:03:14,040 --> 00:03:16,740
+وتستفيدوا منها إن شاء الله بالنسبة للدرجات وهذا 
+
+41
+00:03:16,740 --> 00:03:21,700
+الموضوع اللي بهمكوا كثير الأمر كالعادي يعني الـ
+
+42
+00:03:21,700 --> 00:03:26,540
+midterm عادي 25 درجة الـ final exam 60 درجة الـ 
+
+43
+00:03:26,540 --> 00:03:30,780
+attendance خمس درجات والـ quizzes عشر درجات ولو 
+
+44
+00:03:30,780 --> 00:03:33,860
+ما أخذناش الـ quizzes هنضم العشرة درجات للمين للـ
+
+45
+00:03:33,860 --> 00:03:35,360
+midterm إن شاء الله للـ midterm
+
+46
+00:03:38,090 --> 00:03:43,190
+محتوى المساق محتوى غزير ومحتوى رائع جدا وأنا أود 
+
+47
+00:03:43,190 --> 00:03:48,550
+أن أقدم يعني تقديم بسيط لهذا المساق يمكن من أضعف 
+
+48
+00:03:48,550 --> 00:03:55,070
+النقاط في مجال التحاليل الطبية في قطاع غزة ومجال الـ 
+
+49
+00:03:55,070 --> 00:04:01,430
+virus لماذا أضعف النقطة؟ لأن التكلفة تبع الزراعة 
+
+50
+00:04:01,430 --> 00:04:07,250
+تحت الفيروسات عالية وغير متوفرة في معظم المؤسسات 
+
+51
+00:04:07,250 --> 00:04:11,110
+الصحية، حتى الجامعات ومنها جامعتنا، فقط بنوفرها 
+
+52
+00:04:11,110 --> 00:04:16,510
+لما نعمل دراسة، ولكن ليس على شكل روتيني، وبالتالي 
+
+53
+00:04:16,510 --> 00:04:20,730
+نحن بحاجة إلى تطوير هذا المجال ولا يمكن أن نطول هذا 
+
+54
+00:04:20,730 --> 00:04:24,990
+المجال فقط بشراء أجهزة ومعدات ومواد وإنما يجب أن 
+
+55
+00:04:24,990 --> 00:04:27,930
+نطور الكوادر البشرية اللي هي مثل حضراتكم فهذا 
+
+56
+00:04:27,930 --> 00:04:31,410
+المساق هيجتمل إن شاء الله على كم كبير من 
+
+57
+00:04:31,410 --> 00:04:34,870
+المعلومات صحيح صعب .. صعب عليكم في الامتحان لكن 
+
+58
+00:04:34,870 --> 00:04:39,110
+الآخر بيطلع منها وناس مؤهلين بشكل جيد إن شاء الله 
+
+59
+00:04:39,110 --> 00:04:43,350
+أنا قسمت المساق إلى قسمين قسم part one و part two
+
+60
+00:04:43,350 --> 00:04:46,950
+part one هو الـ basic virology والـ part two هو الـ
+
+61
+00:04:46,950 --> 00:04:51,490
+clinical virology طبعا الـ basic صعب علينا نتكلم عن 
+
+62
+00:04:51,490 --> 00:04:56,190
+طب وعن أمراض فيروسية دون أننا نعرف التفاصيل عن 
+
+63
+00:04:56,190 --> 00:05:00,370
+الفيروسات و صفاتها وتركيبها وطريقة تكاثرها 
+
+64
+00:05:00,370 --> 00:05:03,770
+بالضبط زي ما أخذنا في البكتيريا أخذنا essential و
+
+65
+00:05:03,770 --> 00:05:05,870
+medical وبعدين أخذنا diagnostic و micro وقبل
+
+66
+00:05:05,870 --> 00:05:09,790
+فأنا فيه basic virology الـ structure تبع الفيروسات
+
+67
+00:05:09,790 --> 00:05:13,310
+الـ replication والـ replication تبع الفيروس أصلا 
+
+68
+00:05:13,310 --> 00:05:15,950
+بميزة عن باقي المخلوقات وهنتكلم عنه بعد قليل
+
+69
+00:05:16,620 --> 00:05:19,620
+Genetic and gene therapy، يا هل ترى الفيروسات 
+
+70
+00:05:19,620 --> 00:05:24,060
+يحكمها نفس ما يحكم البكتيريا والإنسان من مادة 
+
+71
+00:05:24,060 --> 00:05:29,500
+وراثية ونظم للوراثة، هذا ما سنتعرف عليه إن شاء 
+
+72
+00:05:29,500 --> 00:05:32,540
+الله في هذا الفصل Classification of medically 
+
+73
+00:05:32,540 --> 00:05:38,680
+important viruses زي ما في بكتيريا مفيدة وبكتيريا 
+
+74
+00:05:38,680 --> 00:05:42,500
+ضارة وزي ما في بكتيريا ممرضة وبكتيريا محتملها 
+
+75
+00:05:42,500 --> 00:05:46,480
+تكون ممرضة، أيضا الفيروسات لا نستطيع أن نقول عنها 
+
+76
+00:05:46,480 --> 00:05:50,600
+كلها medically important، في كثير منها بالعكس 
+
+77
+00:05:50,600 --> 00:05:54,300
+medically important من ناحية عكسية، نحن نستخدمها 
+
+78
+00:05:54,300 --> 00:05:57,420
+في قتل البكتيريا، على سبيل المثال زي الـ
+
+79
+00:05:57,420 --> 00:06:02,480
+bacteriophages يعني مثلا كعلاج مش كفيه فيروسات 
+
+80
+00:06:02,480 --> 00:06:05,640
+بتصيبش الإنسان بتصيب الحيوان فيه بتصيبش الإنسان 
+
+81
+00:06:05,640 --> 00:06:09,300
+والحيوان فيه بتصيب النباتات وبالتالي فيه فيروسات 
+
+82
+00:06:09,300 --> 00:06:16,380
+بالفعل لا تهم سريريا أو طبيا هذا الفيروس الذي 
+
+83
+00:06:16,380 --> 00:06:20,820
+نختلف على ما إذا كان أصلا كائن حي أو غير كائن حي
+
+84
+00:06:22,900 --> 00:06:28,600
+كيف له أن يحدث مرض للإنسان؟ ما الذي يؤهله؟ ما هي 
+
+85
+00:06:28,600 --> 00:06:32,900
+مكوناته؟ ما هي جيناته؟ ما هي إنزيماته؟ كيف له أن 
+
+86
+00:06:32,900 --> 00:06:38,510
+يحدث مرض؟ هذا بيسميه pathogenesis كيف لرسم الإنسان
+
+87
+00:06:38,510 --> 00:06:42,050
+أن يتقي هذا الفيروس وأن يكافحه وأن هثير بالمرض 
+
+88
+00:06:42,050 --> 00:06:47,190
+بالـ influenza وهي فيروس وبالرشح وهي فيروس ونشفى 
+
+89
+00:06:47,190 --> 00:06:51,370
+تلقائيا دون ما تدخل علاجي يبقى في عندنا host 
+
+90
+00:06:51,370 --> 00:06:55,530
+defense يعني في عندنا مناعة ضد الفيروسات كيف لهذه 
+
+91
+00:06:55,530 --> 00:06:59,710
+المناعة أو كيف تعمل هذه المناعة الـ laboratory
+
+92
+00:06:59,710 --> 00:07:04,250
+diagnosis تشخيص المخبري للفيروسات قاعدين نتكلم على 
+
+93
+00:07:04,250 --> 00:07:08,990
+ضعف شديد في هذا المجال antiviral drugs وأنا سأكون 
+
+94
+00:07:08,990 --> 00:07:13,630
+يعني خفيف معاكم في هذا الجانب لإنه كم من العقاقير 
+
+95
+00:07:13,630 --> 00:07:19,410
+عالي جدا وأسمائها صعبة فهنكتفي في غالبا بأسماء 
+
+96
+00:07:19,410 --> 00:07:24,550
+العائلات تبع هذه العقاقير الوصول الأخير من الـ part 
+
+97
+00:07:24,550 --> 00:07:30,340
+one اللي هو الـ viral vaccines يعني شرر الأطفال أعلن 
+
+98
+00:07:30,340 --> 00:07:33,880
+قبل عامين أن فلسطين خالية من شرر الأطفال من قبل 
+
+99
+00:07:33,880 --> 00:07:38,260
+مرضى الصحة العالمية شرر الأطفال مرض فيروسي كيف 
+
+100
+00:07:38,260 --> 00:07:42,980
+تخلص العالم من هذا المرض الفيروسي من خلال التطعيمات 
+
+101
+00:07:42,980 --> 00:07:47,700
+اللي هي الـ vaccines بتسمعوا بالـ smallpox smallpox
+
+102
+00:07:47,700 --> 00:07:50,760
+اللي هو الجدري مش الجدري اللي بتعرفوه أنتو جدر 
+
+103
+00:07:50,760 --> 00:07:56,340
+الماء أو بيسموه chickenpox لأ هذا جدري 
+
+104
+00:07:57,160 --> 00:08:02,180
+تم القضاء عليه أيضا من خلال من خلال تطعيمات وتطعيمات 
+
+105
+00:08:02,180 --> 00:08:06,340
+كانت فعالة جدا لدرجة أنه بالفعل آخر حالة 
+
+106
+00:08:06,340 --> 00:08:10,600
+سجلت كانت في العام ألف وتسعمائة وتسعة وسبعين لمريض 
+
+107
+00:08:10,600 --> 00:08:15,660
+سوداني أصيب بهذا المرض الخبيث وتم القضاء عليه إذا 
+
+108
+00:08:15,660 --> 00:08:20,840
+الـ viral vaccines مهمة جدا جدا في عملية التخلص 
+
+109
+00:08:20,840 --> 00:08:25,860
+منها من الأمراض الفيروسية الـ part two هلاجي أول 
+
+110
+00:08:25,860 --> 00:08:30,760
+أربع عناوين DNA envelope viruses DNA non envelope
+
+111
+00:08:30,760 --> 00:08:36,060
+viruses RNA envelope وRNA non envelope إيش التصنيف 
+
+112
+00:08:36,060 --> 00:08:41,020
+هذه العجيبة؟ عندنا تصنيف للمادة الوراثية للفيروسات 
+
+113
+00:08:41,020 --> 00:08:47,580
+يا جماعة يا إما DNA يا إما RNA لكن ليس كلاهما 
+
+114
+00:08:47,580 --> 00:08:53,440
+لا يوجد داخل الفيروس اثنين اللي هم الـ DNA والـ RNA،
+
+115
+00:08:53,440 --> 00:08:57,100
+يا إما RNA يا إما DNA، وأصلا لا يوجد في الدنيا 
+
+116
+00:08:57,100 --> 00:09:01,440
+مخلوقات بنعرفها المادة الوراثية تبعتها RNA إلا من؟
+
+117
+00:09:01,440 --> 00:09:06,460
+إلا الفيروس، اللي أنا صففنا based on DNA أو RNA،
+
+118
+00:09:06,460 --> 00:09:12,560
+في كمان تصنيف، في بعض الفيروسات تمتلك envelope غلاف 
+
+119
+00:09:12,560 --> 00:09:17,300
+خارجي تمام؟ بنسميه envelope فاللي تمتلك هذا الغلاف 
+
+120
+00:09:17,300 --> 00:09:21,420
+بنسميها enveloped واللي ما تمتلكه بنسميها non 
+
+121
+00:09:21,420 --> 00:09:27,140
+-enveloped أو naked تمام؟ يا إما naked يا إما non
+
+122
+00:09:27,140 --> 00:09:30,080
+-enveloped فالآن بالضبط زي ما كنا في البكتيريا 
+
+123
+00:09:30,080 --> 00:09:32,800
+نقول gram positive و gram negative ونقول بصي لاي 
+
+124
+00:09:32,800 --> 00:09:37,040
+ونقول كوكساي هلق نقول DNA viruses يا إما 
+
+125
+00:09:37,040 --> 00:09:40,180
+enveloped يا إما non-enveloped RNA enveloped أو 
+
+126
+00:09:40,180 --> 00:09:44,940
+non-enveloped إذا تصنيفها سهلة لهذه الفيروسات أنا 
+
+127
+00:09:44,940 --> 00:09:48,560
+كمان مجموعة مهمة جدا من الفيروسات تسمى Hepatitis
+
+128
+00:09:48,560 --> 00:09:55,580
+viruses لا تمتلك مقومات الشراكة في مجموعة إلا مقوم
+
+129
+00:09:55,580 --> 00:10:00,260
+واحد، إيش هو هذا المقوم؟ إنها كلها بتصيب الكبد،
+
+130
+00:10:00,260 --> 00:10:04,080
+يعني الـ target تبعها الكبد، أعطيكم أمثلة،
+
+131
+00:10:04,080 --> 00:10:09,980
+Hepatitis A تختلف تقريبا عن B تختلف تقريبا عن C،
+
+132
+00:10:09,980 --> 00:10:14,110
+في الـ structure و في الـ العائلة لكن بنسميها Hepatitis
+
+133
+00:10:14,110 --> 00:10:17,970
+A و Hepatitis B و Hepatitis C لإن كلهم بيشتركوا
+
+134
+00:10:17,970 --> 00:10:22,430
+بيصيبوا مين اللي هو الكبد طبعا هم صاروا ستة الآن
+
+135
+00:10:22,430 --> 00:10:28,030
+Hepatitis A و B و C و D أو Delta و فيه هنا E و فيه
+
+136
+00:10:28,030 --> 00:10:31,710
+هنا G يبقى فيه هنا مجموعة كبيرة من الفيروسات
+
+137
+00:10:31,710 --> 00:10:37,010
+سميناهم Hepatitis Virus في مجموعة أخرى كمان مهمة
+
+138
+00:10:37,010 --> 00:10:41,680
+اسمها Arboviruses و Arbo جاية من كلمة Arthropod
+
+139
+00:10:41,680 --> 00:10:45,400
+والـ Arthropod مرض عليكم قبل هيك مفصليات الأرجل
+
+140
+00:10:45,400 --> 00:10:52,960
+الحشرات يعني و borne فـ الـ ar اللي هي r  هدى عبارة عن
+
+141
+00:10:52,960 --> 00:11:00,600
+Arthro والـ pod بي والـ  o هى من borne كلمة borne لما
+
+142
+00:11:00,600 --> 00:11:03,740
+نقول food borne diseases الأمراض المنتقلة عن طريق
+
+143
+00:11:03,740 --> 00:11:09,050
+الغذاء Arthropod borne diseases الأمراض المنتقلة عن
+
+144
+00:11:09,050 --> 00:11:14,150
+طريق الحشرات، Arboviruses هي فيروسات تنتقل عن
+
+145
+00:11:14,150 --> 00:11:19,470
+طريق من الحشرات، تسمعوا أن الفيروسات بتسبب سرطان؟
+
+146
+00:11:20,300 --> 00:11:24,000
+مين هدول معانا اليوم الدراسة اللي عملناها للـ .. للـ
+
+147
+00:11:24,000 --> 00:11:28,740
+.. السرطان؟ أنا عملت محاضرة وتحدثت على إن ما نسبته
+
+148
+00:11:28,740 --> 00:11:33,320
+حوالي عشرين بالمائة من السرطانات اللي بتصيب البشر
+
+149
+00:11:33,320 --> 00:11:39,800
+سببها micro organism بكتيريا أو فيروسات أو طفيليات
+
+150
+00:11:39,800 --> 00:11:45,600
+الناس بلا بأس بها من السرطانات تحدثها micro
+
+151
+00:11:45,600 --> 00:11:49,180
+organism منها الفيروسات هذه الفيروسات احنا بنسميها
+
+152
+00:11:49,180 --> 00:11:54,920
+tumor viruses يعني الفيروسات التي تنتج الأورام
+
+153
+00:11:54,920 --> 00:11:59,360
+ومن ضمن هذه الأورام هي السرطانة في مجموعة أخرى
+
+154
+00:11:59,360 --> 00:12:05,000
+اسمها slow viruses and prions كلمة slow viruses
+
+155
+00:12:05,000 --> 00:12:11,860
+توحي بأن الفيروس بطيء أو المرض اللي يسببه الفيروس
+
+156
+00:12:11,860 --> 00:12:16,660
+بيعمل slow progression يعني تقدمه في الإنسان بيكون
+
+157
+00:12:16,660 --> 00:12:21,220
+بطيء بده سنوات حتى يحدث هذا المرض هذا الشق الأول
+
+158
+00:12:21,220 --> 00:12:25,220
+من الموضوع الشق الثاني اللي هي الـ prions الـ prions
+
+159
+00:12:25,220 --> 00:12:30,110
+يا بنات احنا يعني لما زمان زمان قبل الميكروسكوبات
+
+160
+00:12:30,110 --> 00:12:33,510
+الشيء الوحيد اللي كنا نعرفه أنه parasite هو
+
+161
+00:12:33,510 --> 00:12:36,750
+الحشرات الكبيرة زي الجمل اللي كنا نشوفها أما على
+
+162
+00:12:36,750 --> 00:12:41,730
+الرأس أو على الاسم طورنا شوية صار إن الميكروسكوبات
+
+163
+00:12:41,730 --> 00:12:46,150
+صاروا ناعمة في الـ bacteria لما اكتشفنا الـ virus
+
+164
+00:12:46,150 --> 00:12:51,870
+كانت نقلة نوعية في المعرفة البشرية إن في مخلوقات
+
+165
+00:12:51,870 --> 00:12:57,140
+أصغر من مين من الـ bacteria في تسعينات القرن الماضي
+
+166
+00:12:57,140 --> 00:13:04,020
+اكتشفنا إن في أصلا مادة عضوية ليس لها أي خصائص
+
+167
+00:13:04,020 --> 00:13:08,800
+حياة ليه الـ prions اللي بتسبب مرض جنون البقر
+
+168
+00:13:08,800 --> 00:13:16,540
+بالمناسبة في مرض جنون البشر يعني المقابل له الـ
+
+169
+00:13:16,540 --> 00:13:20,620
+prions عبارة عن مجموعة من البروتينات normally
+
+170
+00:13:20,620 --> 00:13:25,230
+found in our bodies يعني مولودة فينا احنا بس بتكون
+
+171
+00:13:25,230 --> 00:13:31,650
+normal ونفترض شكلها هيك هذا normal إذا تحول إلى
+
+172
+00:13:31,650 --> 00:13:37,550
+شكل آخر بتصير abnormal كيف تتكاثر هذه الـ abnormal
+
+173
+00:13:37,550 --> 00:13:43,810
+بيلتقي مع الـ normal بيخليه abnormal بمعنى آخر هو
+
+174
+00:13:43,810 --> 00:13:48,480
+بتكاثرش تكاثر فعلي وإنما بيحول الـ Normal إلى
+
+175
+00:13:48,480 --> 00:13:52,360
+Abnormal فبيكتر من مين؟ من الـ Abnormal وكانوا قاعد
+
+176
+00:13:52,360 --> 00:13:57,820
+بتكاثر وهذا اسمه protein infectious واقتصرناهم
+
+177
+00:13:57,820 --> 00:14:02,760
+واسميناهم Prions إذن الـ Prions هي ليست مخلوقات
+
+178
+00:14:02,760 --> 00:14:07,100
+حية وإنما مخلوقات غير حية هي عبارة عن protein لا
+
+179
+00:14:07,100 --> 00:14:13,380
+تحتوي على مادة وراثية ألبس النقطة
+
+180
+00:14:13,380 --> 00:14:18,520
+اللي بعديها Human Immunodeficiency Virus اللي هو
+
+181
+00:14:18,520 --> 00:14:23,220
+مرض أو فيروس عواز المناعة أو نقص المناعة اللي هو الـ
+
+182
+00:14:23,220 --> 00:14:27,740
+AIDS فيروس الـ AIDS وكلكم
+
+183
+00:14:27,740 --> 00:14:32,800
+بتعرفوا أن هذا الفيروس منذ اكتشافه أجريت عليه
+
+184
+00:14:32,800 --> 00:14:37,120
+دراسات عديدة لدرجة أن هذه الدراسات كان لها أثر كبير
+
+185
+00:14:37,120 --> 00:14:41,980
+في تطور علم الـ biology وعلم الـ immunology بشكل عام
+
+186
+00:14:43,340 --> 00:14:46,400
+على الرغم إن احنا لحد الآن ما اتشفناش علاج فعال
+
+187
+00:14:46,400 --> 00:14:52,780
+للفيروس يعني في علاجات لكن مش ناجعة تماما في
+
+188
+00:14:52,780 --> 00:14:58,520
+القضاء عليه ولا قدرنا نحصل على vaccine يمنع حدوث هذا
+
+189
+00:14:58,520 --> 00:15:02,440
+المرض إلا أن الدراسات المصاحبة بالفعل ساهمت في
+
+190
+00:15:02,440 --> 00:15:07,730
+تطوير علم المناعة وعلم الفيروسة وطبعا بتعرفوا كل
+
+191
+00:15:07,730 --> 00:15:11,150
+سنة بيحتفلوا بيوم الـ .. بيوم الـ AIDS العالمي دلالة
+
+192
+00:15:11,150 --> 00:15:16,330
+على أن هذا المرض ما زال بيحتل مكانة كبيرة في الطب
+
+193
+00:15:16,330 --> 00:15:19,570
+في العالم والنقطة الأخيرة إذا أسعفنا الوقت اللي هي
+
+194
+00:15:19,570 --> 00:15:23,530
+الـ minor viral pathogen كلمة minor viral pathogen
+
+195
+00:15:23,530 --> 00:15:30,150
+مصطلح فضفاض ليس مصطلح دقيق فبنحاول نفسر لكم إيه ما
+
+196
+00:15:30,150 --> 00:15:34,810
+المقصود فيه لو عرفنا أنه منطقة ما جغرافية في
+
+197
+00:15:34,810 --> 00:15:39,830
+العالم بيحدث فيها وباء بفيروس محدد ولا ينتقل هذا
+
+198
+00:15:39,830 --> 00:15:45,290
+الفيروس إلى أي دولة ثانية هذا بيعتبره minor بيحصل
+
+199
+00:15:45,290 --> 00:15:51,030
+مثلا كل عشرين سنة وباء محدود بيسموه minor لكن ما
+
+200
+00:15:51,030 --> 00:15:55,870
+رأيكم باسم West Nile Virus West Nile حمال نيل
+
+201
+00:15:55,870 --> 00:16:00,430
+الغربي صح؟ إيش يعني حمال نيل الغربي؟ يعني حمى
+
+202
+00:16:00,430 --> 00:16:06,200
+اكتشفوها في مناطق حوض النيل الغربي طب هاد الـ .. الـ
+
+203
+00:16:06,200 --> 00:16:07,840
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+204
+00:16:07,840 --> 00:16:08,020
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ال
+
+205
+00:16:08,020 --> 00:16:08,060
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+206
+00:16:08,060 --> 00:16:08,320
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ال
+
+207
+00:16:08,320 --> 00:16:08,340
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+208
+00:16:08,340 --> 00:16:14,220
+الـ .. الـ .. الـ ..
+
+209
+00:16:14,220 --> 00:16:19,320
+الـ ..
+
+210
+00:16:19,320 --> 00:16:19,340
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ال
+
+211
+00:16:19,340 --> 00:16:19,620
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+212
+00:16:19,620 --> 00:16:19,940
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ال
+
+213
+00:16:19,940 --> 00:16:20,160
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+214
+00:16:20,160 --> 00:16:31,700
+الـ .. الـ ..
+
+215
+00:16:32,620 --> 00:16:37,320
+التغير المناخي اللي حاصل في العالم بلدان كانت أصلا
+
+216
+00:16:37,320 --> 00:16:41,680
+حارة اليوم صارت معتدلة أنت بتعرف إن بريطانيا زرع
+
+217
+00:16:41,680 --> 00:16:46,800
+فيها زيتون قبل كم سنة نجحتها في زراعة زيتون طبعا
+
+218
+00:16:46,800 --> 00:16:49,620
+الزيتون كان حلم إن ينزلها في وين في بريطانيا إنه
+
+219
+00:16:49,620 --> 00:16:53,080
+يعني هو بنزلها بس ما بيحملش ثمر يعني فالقصد من
+
+220
+00:16:53,080 --> 00:16:57,200
+الكلام احنا في غزة هنا أصبح لدينا أنواع من البعوض
+
+221
+00:16:57,200 --> 00:17:02,270
+لم نكن نعرفها من قبل سموها tiger mosquito اللي
+
+222
+00:17:02,270 --> 00:17:06,610
+بتكون مخططة زي الـ .. و لساعتها مزعجة جدا أعتقد
+
+223
+00:17:06,610 --> 00:17:10,590
+بيسموها Aedes Aegypticus أو الزعجة المصرية يعني هي
+
+224
+00:17:10,590 --> 00:17:18,310
+بعوضة من مصر هذا التغير في المناخ وسهولة السفر
+
+225
+00:17:18,310 --> 00:17:23,170
+أصبح أو جعل من إمكانية انتقال الأمراض من مكان
+
+226
+00:17:23,170 --> 00:17:28,300
+جغرافي إلى آخر إمكانية عالية كلمة minor الآن هي
+
+227
+00:17:28,300 --> 00:17:32,860
+minor لكن في المستقبل قد تكون major ومنتشرة بشكل
+
+228
+00:17:32,860 --> 00:17:37,160
+كام طيب
+
+229
+00:17:37,160 --> 00:17:43,020
+الآن ما نفعش إنه ندخل على الفيروسات وعلى الطب
+
+230
+00:17:43,020 --> 00:17:47,420
+تبع الفيروسات دون ما معرفة ماهي .. ماهية
+
+231
+00:17:47,420 --> 00:17:54,390
+الفيروسات، بنتفق عليها تماما أول نقطة أساسية تميز
+
+232
+00:17:54,390 --> 00:17:58,110
+الفيروسات عن باقي المخلوقات their obligate
+
+233
+00:17:58,110 --> 00:18:02,810
+intracellular replication حد هيقول لي دارس
+
+234
+00:18:02,810 --> 00:18:05,210
+diagnostic microbial يقول لي دكتور ما احنا درسنا
+
+235
+00:18:05,210 --> 00:18:10,290
+التنتين بكتيريا الكلاميديا والريكيزيا التنتين
+
+236
+00:18:10,290 --> 00:18:13,770
+obligate intracellular برضه كلامكم صحيح هذا وجه
+
+237
+00:18:13,770 --> 00:18:18,630
+التشابه الوحيد بين هدول التنتين والفيروسات لكن
+
+238
+00:18:18,630 --> 00:18:23,610
+بالإضافة إلى هذه المعلومة إن الـ replication of
+
+239
+00:18:23,610 --> 00:18:28,250
+viruses is so different from that of other
+
+240
+00:18:28,250 --> 00:18:33,310
+microorganisms، ليش؟ احنا capable من التكاثر عننا،
+
+241
+00:18:33,310 --> 00:18:37,490
+من الانقسام عننا، الخلية بتصير، بتنتهي، مصبوط؟
+
+242
+00:18:37,490 --> 00:18:42,930
+والبكتيريا كذلك الأمر، البكتيريا بالانقسام الثنائي
+
+243
+00:18:42,930 --> 00:18:47,310
+البسيط، احنا بالـ meiosis و الـ mitosis، صح ولا لأ؟ لكن
+
+244
+00:18:47,310 --> 00:18:52,630
+الفيروسات بيدخل الفيروس داخل خلية بيطلع مئات
+
+245
+00:18:52,630 --> 00:18:58,070
+الفيروس يبقى طريقة التكاثر معاها unique فريدة
+
+246
+00:18:58,070 --> 00:19:02,710
+متميزة متفردة عن باقي المخلوقات إذا obligate
+
+247
+00:19:02,710 --> 00:19:08,070
+intracellular parasite رقم اثنين they reproduce in
+
+248
+00:19:08,070 --> 00:19:10,870
+a manner different from that dose of prokaryotes
+
+249
+00:19:10,870 --> 00:19:13,610
+and eukaryotes يعني مش زي الخلايا
+
+250
+00:19:16,370 --> 00:19:20,650
+طبعا هدول النقطتين مهمين جدا لكن النقطة اللي أهم
+
+251
+00:19:20,650 --> 00:19:26,970
+من ذلك المحتوى الوراثي المحتوى الوراثي ذكرنا قبل
+
+252
+00:19:26,970 --> 00:19:32,530
+قليل أنه الفيروسات تحتوي على مادة وراثية يا إما DNA يا 
+
+253
+00:19:32,530 --> 00:19:37,950
+إما RNA but never both بينما كل المخلوقات الأخرى
+
+254
+00:19:37,950 --> 00:19:43,470
+تحتوي على كل من الـ DNA و الـ RNA إذا هذا فرق أساسي
+
+255
+00:19:43,470 --> 00:19:49,540
+ومهم جدا بعض الفيروسات تمتلك ما يسمى بالـ envelope
+
+256
+00:19:49,540 --> 00:19:53,040
+اللي احنا نقول عنها enveloped viruses من وين هذا
+
+257
+00:19:53,040 --> 00:19:57,440
+الـ envelope جاي؟ تخيلوا معايا هاي الفيروس وهي الـ
+
+258
+00:19:57,440 --> 00:20:02,740
+cell membrane بتاع الخلية الـ host الفيروس هو طالع
+
+259
+00:20:02,740 --> 00:20:09,220
+بياخد جزء من الـ membrane بيقطعه و بيطلع فيه برا فالـ
+
+260
+00:20:09,220 --> 00:20:12,820
+membrane هذا الآن صار مين؟ محيط بالـ virus لاحظوا
+
+261
+00:20:12,820 --> 00:20:19,330
+شغلة أن وجود هذا الـ membrane له مزايا و له عيوب
+
+262
+00:20:19,330 --> 00:20:25,610
+إيش مزايا بتتوقعوا؟ مدام هو جزء من الـ host cell
+
+263
+00:20:25,610 --> 00:20:31,610
+لو بديعمل infection لخلية تانية مابيحتاجش إلى 
+
+264
+00:20:31,610 --> 00:20:36,190
+receptors بس بيعمل fusion بيرتبط الـ membrane مع الـ
+
+265
+00:20:36,190 --> 00:20:41,630
+membrane و الفيروس يدخل جوا بكل سهولة صح؟ هذا رقم
+
+266
+00:20:41,630 --> 00:20:46,590
+واحد، هذا رقم اثنين جهاز المناعة بتعرفش عليه، ليش؟
+
+267
+00:20:47,110 --> 00:20:52,150
+ما هو جزء من مين؟ من الـ host، سرق، إذا في مزيتين،
+
+268
+00:20:52,150 --> 00:20:56,570
+أنه دخوله للخلايا بيصير سهل و بيهرب من مين؟ من 
+
+269
+00:20:56,570 --> 00:21:00,690
+جهاز المناعة، طب إيش عيوبه؟ لو خرج إلى الخارج،
+
+270
+00:21:00,690 --> 00:21:07,230
+خارج الجسم، على الأسطح مثلا، و جف قليلا، بيخرب الـ
+
+271
+00:21:07,230 --> 00:21:13,570
+virus لو استخدمنا أي مادة مذيبة للدهون زي الكحول
+
+272
+00:21:13,570 --> 00:21:18,530
+البسيط بيدمر الـ cell membrane إذا دمر الـ cell
+
+273
+00:21:18,530 --> 00:21:21,170
+membrane اللي هو الـ envelope بيبطل الفيروس قادر
+
+274
+00:21:21,170 --> 00:21:26,430
+على مين؟ على الارتباط و دخول الخلايا، إذا خدنا نقول
+
+275
+00:21:26,430 --> 00:21:30,170
+أنه له مزايا داخل الجسم و له عيوب خارج الجسم أنه
+
+276
+00:21:30,170 --> 00:21:35,530
+environmentally مش stable يعني غير قادر على ثبات
+
+277
+00:21:35,530 --> 00:21:42,570
+لفتررات طويلة في البيئة أدللكم بمثال بسيط، بتعرفوا
+
+278
+00:21:42,570 --> 00:21:46,070
+الفيروس اللي بيعمل أمراض في الـ intestine، في
+
+279
+00:21:46,070 --> 00:21:50,410
+القمعة يعني، مثلا زي الإسهال، زي الـ rotavirus، لو
+
+280
+00:21:50,410 --> 00:21:53,690
+تخيلنا هذا له envelope، و احنا أكلناه، when
+
+281
+00:21:53,690 --> 00:21:58,570
+هيموت؟ على المعدة المعدة فيها حامض الحامض مش بيعمل
+
+282
+00:21:58,570 --> 00:22:04,570
+بيذيب الدهون فمستحيل اللاجي فيروس بيعمل
+
+283
+00:22:04,570 --> 00:22:11,030
+gastroenteritis و يكون له envelope وصل الصورة الـ
+
+284
+00:22:11,030 --> 00:22:15,390
+envelope بيعطيه instability إيش هالـ instability؟
+
+285
+00:22:15,390 --> 00:22:19,890
+عدم استقرار و عدم ثبات بينما الفيروسات اللي مالهاش 
+
+286
+00:22:19,890 --> 00:22:25,840
+envelope غالبا بتكون ثابتة في البيئة كل الفيروسات
+
+287
+00:22:25,840 --> 00:22:30,140
+اللي بتعمل gastrointestinal tract infection مالهاش 
+
+288
+00:22:30,140 --> 00:22:39,720
+envelope في فيروس شهير صديق لكم فيروس رino هذا
+
+289
+00:22:39,720 --> 00:22:46,400
+صغير جدا و لا يمتلك envelope و عدم امتلاكه envelope
+
+290
+00:22:46,400 --> 00:22:53,450
+لو عطسنا و على الطاولة هذه جافة و لا لأ؟ الأصل لو أنه
+
+291
+00:22:53,450 --> 00:22:57,910
+.. أنه .. لو له envelope بيحصل فيه بيجف و بيتدمر
+
+292
+00:22:57,910 --> 00:23:01,910
+بينما لإنه مالوش فبيبقى لفترات طويلة بيجي حاضر
+
+293
+00:23:01,910 --> 00:23:05,450
+واحد بيمسك الطاولة هادي وبعد شوية بيحك عينه أو 
+
+294
+00:23:05,450 --> 00:23:10,630
+بيحك أنفه أو بيتناول طعام بي .. بيت .. بينتقل الـ
+
+295
+00:23:10,630 --> 00:23:14,590
+microbe من الـ surfaces إلى الإنسان لإنه
+
+296
+00:23:14,590 --> 00:23:19,750
+environmentally stable مالوش envelope تمام؟
+
+297
+00:23:22,610 --> 00:23:27,550
+بالنسبة للفروقات الأخرى ما بين الـ virus و الـ other
+
+298
+00:23:27,550 --> 00:23:32,390
+cells كل الخلايا ما عدا البكتيريا طبعا تحتوي على
+
+299
+00:23:32,390 --> 00:23:36,970
+نواة حقيقية الفيروس ماعندوش نواة كل الخلايا ما عدا
+
+300
+00:23:36,970 --> 00:23:41,650
+البكتيريا عندها mitochondria بينما الفيروسات
+
+301
+00:23:41,650 --> 00:23:46,670
+ماعندهاش أي شيء ribosomes البكتيريا و الـ other
+
+302
+00:23:46,670 --> 00:23:51,170
+cells عندهم ribosomes لكن الفيروسات ماعندهاش
+
+303
+00:23:52,430 --> 00:23:57,970
+الفيروس لا يمتلك من مقومات الخلايا الحية إلا حاجة
+
+304
+00:23:57,970 --> 00:24:01,730
+واحدة قدرته على الـ replication يا جماعة قدرته على
+
+305
+00:24:01,730 --> 00:24:08,090
+الـ replication وهي محدودة وين؟ في host يعني مش برا
+
+306
+00:24:08,090 --> 00:24:10,950
+زي البكتيريا البكتيريا تقدر تعيش معيشة حرة هذا
+
+307
+00:24:10,950 --> 00:24:17,630
+بعيش معيشة حرة قلبها الجدول البسيط بيحاول أنه يفرق
+
+308
+00:24:17,630 --> 00:24:21,510
+ما بين طبعا تلخيص لما ذكرناه لكن بس أن نمر عليهم
+
+309
+00:24:21,510 --> 00:24:27,730
+مرور بشكل سريع المادة الوراثية الـ viruses يكون يا
+
+310
+00:24:27,730 --> 00:24:32,410
+إما DNA يا إما RNA بينما الخلايا كل من الـ DNA و الـ
+
+311
+00:24:32,410 --> 00:24:36,010
+RNA موجودين بالنسبة للـ proteins في الفيروسات
+
+312
+00:24:36,010 --> 00:24:42,230
+موجودة لكن قليلة بينما يعني عماد تكوين الخلايا
+
+313
+00:24:42,230 --> 00:24:46,120
+الأخرى غالبا بيكون من مين؟ من الـ protein فلازم تكون
+
+314
+00:24:46,120 --> 00:24:51,280
+كثيرة أيضا عندنا الـ lipoprotein membrane الـ
+
+315
+00:24:51,280 --> 00:24:54,740
+lipoprotein membrane في الخلايا العادية بيكون
+
+316
+00:24:54,740 --> 00:24:57,540
+موجود بكثرة سواء كان في النواة أو في الـ cell
+
+317
+00:24:57,540 --> 00:25:01,860
+membrane بينما في الـ viruses لم نجده إلا في الـ
+
+318
+00:25:01,860 --> 00:25:06,700
+enveloped viruses و مأخوذ من مين؟ من الـ host cell
+
+319
+00:25:06,700 --> 00:25:09,600
+يعني مش هو اللي بيصنعه مأخوذ أيضا من الـ host cell
+
+320
+00:25:10,260 --> 00:25:13,820
+الـ ribosomes بيقولنا غير موجودة في الفيروسات بس في
+
+321
+00:25:13,820 --> 00:25:19,380
+إشارة خدوا بالكم جنب كلمة absent و تحت الجدول في
+
+322
+00:25:19,380 --> 00:25:25,760
+تعليق عليها بيقولكوا استثناء واحد لفيروس اسمه
+
+323
+00:25:25,760 --> 00:25:32,740
+Arena virus و Arena من حلبة حلبة بجد تكون المفروضة
+
+324
+00:25:32,740 --> 00:25:36,870
+بالرمل وسموا الفيروس هذا لما شافوا تحت الـ
+
+325
+00:25:36,870 --> 00:25:40,710
+microscope لجوا أنه فيه granules granules يعني
+
+326
+00:25:40,710 --> 00:25:44,610
+حبيبات فذكرتهم باسم arena اللي هي الحلبة اللي فيها
+
+327
+00:25:44,610 --> 00:25:50,190
+الرمل تمام فسموه arena virus لما كشفوا عن الـ .. الـ
+
+328
+00:25:50,190 --> 00:25:54,170
+.. الـ .. الحبيبات هذه لجوها عبارة عن ribosomes
+
+329
+00:25:54,170 --> 00:25:57,330
+طبعا اللي على بعض يقولون أنها non-functional إيش
+
+330
+00:25:57,330 --> 00:26:05,730
+يعني non-functional؟ يعني مالهاش .. مالهاش وظيفة؟ يعني
+
+331
+00:26:05,730 --> 00:26:09,750
+غير فعالة مافيش فيها لكن أنا دايما بفضل مصطلح
+
+332
+00:26:09,750 --> 00:26:13,950
+أن احنا مش عارفين إيش وظيفتها لكن عموما الفيروسات
+
+333
+00:26:13,950 --> 00:26:18,350
+كلها ما عدا هذا الفيروس لا تحتوي على ribosomes
+
+334
+00:26:18,350 --> 00:26:22,270
+بينما المخلوقات الأخرى كلها فيها ribosomes
+
+335
+00:26:22,270 --> 00:26:26,990
+بينما المخلوقات الأخرى كلها فيها ribosomes
+
+336
+00:26:26,990 --> 00:26:31,150
+بينما المخلوقات الأخرى كلها فيها ribosomes
+
+337
+00:26:31,770 --> 00:26:35,530
+الأنزيمات هل تحتاج الفيروس أن يكون معه انزيمات و
+
+338
+00:26:35,530 --> 00:26:41,510
+لا يحتاجه؟ هل يحتاج الفيروس أن يكون لديه جايب معه
+
+339
+00:26:41,510 --> 00:26:48,230
+انزيمات و لا بيحتاجه؟ طيب إذا افترضنا أن انزيمات
+
+340
+00:26:48,230 --> 00:26:53,260
+الخلية مابتقدريش الغرض أنا بيالقعها هاي تمام؟ و
+
+341
+00:26:53,260 --> 00:26:57,840
+لازمني أنا طبعا في القاعات الأخرى ممكن يكون أو
+
+342
+00:26:57,840 --> 00:27:03,680
+لآخرين بيحطولهم flash أنا نفسي أكسبني الأخ المصور
+
+343
+00:27:03,680 --> 00:27:06,380
+هناك و مش حاطلي flash أنا كل ما أجي هناك لازم أخد
+
+344
+00:27:06,380 --> 00:27:10,680
+معايا مين الـ flash تبعي ففي بعض الانزيمات لا تجد
+
+345
+00:27:10,680 --> 00:27:15,700
+بغياتها في بعض الفيروسات لا تجد بغياتها في مكونات
+
+346
+00:27:15,700 --> 00:27:20,210
+الخلية فبتحضر مكونات معاها جاهزة ففي بعض الفيروس
+
+347
+00:27:20,210 --> 00:27:27,010
+تحتاج إلى بعض الانزيمات لكن قليل جدا قليل جدا بينما
+
+348
+00:27:27,010 --> 00:27:31,870
+الخلايا الخلايا الانزيمات يعني بدون انزيمات مافيش
+
+349
+00:27:31,870 --> 00:27:35,990
+أنا قلتلكم أن خلية بدون protein خلية محكم عليها
+
+350
+00:27:35,990 --> 00:27:43,270
+بالموت و الانزيمات كلها protein عملية الانقسام بالـ
+
+351
+00:27:43,270 --> 00:27:45,930
+binary vision أو الـ mitosis طبعا غير موجودة في
+
+352
+00:27:45,930 --> 00:27:48,830
+الفيروسات بينما موجودة في من؟ في الخلايا
+
+353
+00:27:52,160 --> 00:27:58,800
+ناخد فكرة و تصور عن حجوم الفيروسات أذكركم
+
+354
+00:27:58,800 --> 00:28:01,780
+بالبكتيريا لما عملتوا gram stain و مثلين blue
+
+355
+00:28:01,780 --> 00:28:06,620
+stain و طلعتوا تحت الميكروسكوب و شوفتوا البكتيريا
+
+356
+00:28:06,620 --> 00:28:11,380
+كانت عبارة عن شحطة أو نقطة gram positive أو gram
+
+357
+00:28:11,380 --> 00:28:17,860
+negative و هذه يا بنات الحجم تبعها طول الـ E.coli
+
+358
+00:28:17,860 --> 00:28:21,780
+عايز المثال 3 مايكرون عرضها ثمكة يعني
+
+359
+00:28:26,320 --> 00:28:34,620
+المايكرون ألف نانو متر المايكرون ألف نانو متر ألف
+
+360
+00:28:34,620 --> 00:28:37,580
+نانو متر ألف نانو متر ألف نانو متر ألف نانو متر
+
+361
+00:28:37,580 --> 00:28:37,600
+ألف نانو متر ألف نانو متر ألف نانو متر ألف نانو
+
+362
+00:28:37,600 --> 00:28:37,700
+متر ألف نانو متر ألف نانو متر ألف نانو متر ألف
+
+363
+00:28:37,700 --> 00:28:37,960
+نانو متر ألف نانو متر ألف نانو متر ألف نانو متر
+
+364
+00:28:37,960 --> 00:28:40,800
+ألف نانو متر ألف نانو متر ألف نانو متر ألف نانو
+
+365
+00:28:40,800 --> 00:28:48,640
+متر ألف نانو متر ألف نانو متر ألف نانو متر ألف
+
+366
+00:28:48,640 --> 00:28:56,430
+نانو يعني أشهر بالحجوم لازم نشوفها لازم نشوفها بس
+
+367
+00:28:56,430 --> 00:29:00,270
+خليني قبل ما نشوفها نعمل analogy analogy يعني
+
+368
+00:29:00,270 --> 00:29:05,810
+مقاربة بيقولنا أن أكبر بروتين تقريبا حجمه عشرين
+
+369
+00:29:05,810 --> 00:29:11,510
+نانومتر إذا في فيروسات تشابه في الحجم one single
+
+370
+00:29:11,510 --> 00:29:17,790
+protein و أصغر المخلوقات الحية اللي بنعرفها احنا الـ
+
+371
+00:29:17,790 --> 00:29:21,550
+mycoplasma فاكرينها؟ الـ mycoplasma كبكتيريا هي
+
+372
+00:29:21,550 --> 00:29:27,410
+أصغر بكتيريا تقريبا 400 نانو متر أو 300 نانو متر
+
+373
+00:29:27,410 --> 00:29:33,520
+فبتقول أن أصغر حجم في الفيروسات يساوي أكبر حجم في
+
+374
+00:29:33,520 --> 00:29:38,200
+البروتينات و أكبر حادة في الفيروسات قد تشابه أو قد
+
+375
+00:29:38,200 --> 00:29:45,020
+توازي أصغر بكتيريا اللي هي الـ mycoplasma كيف نطلق
+
+376
+00:29:45,020 --> 00:29:51,860
+الأسماء على الفيروسات؟ فيه أن مصطلح اسمه colloquial
+
+377
+00:29:51,860 --> 00:29:57,540
+terms و colloquial terms يعني مصطلحات هبهزن عشوائية
+
+378
+00:29:57,540 --> 00:30:01,980
+يعني مما نراه نحن بالعامية ما له أساس علمي مثلا
+
+379
+00:30:01,980 --> 00:30:08,140
+بنقول عنها كوريات spheres أو rods عصويات أو مثل
+
+380
+00:30:08,140 --> 00:30:12,520
+الرصاصة على سبيل المثال أو مثل الـ block تبع الطوب
+
+381
+00:30:12,520 --> 00:30:16,710
+تمام اللي بنبني فيه هذا bricks لكن واقع الأمر لو
+
+382
+00:30:16,710 --> 00:30:20,790
+دخلنا في التفاصيل الشكلية لهذه الفيروسات سنجد يا
+
+383
+00:30:20,790 --> 00:30:26,610
+بنات تركيب معقدة جدا ونظام .. خلّيني أسميه 
+
+384
+00:30:26,610 --> 00:30:29,690
+geometrical symmetry إيش هي geometrical symmetry؟
+
+385
+00:30:29,690 --> 00:30:37,970
+تماثل هندسي دقيق جدا لهذه الفيروسة طبعا اللي بيعطي
+
+386
+00:30:37,970 --> 00:30:43,830
+التماثل الدقيق تركيب اسمه capsid الـ capsid عبارة
+
+387
+00:30:43,830 --> 00:30:52,730
+عن protein يحيط بالمادة الوراثية إذا الفيروس الكامل
+
+388
+00:30:52,730 --> 00:30:58,430
+قد يتكون فقط من قطعتين أو من جزئين مادة وراثية
+
+389
+00:30:58,430 --> 00:31:05,410
+نوكليو و من كابسيل و بيسموها نوكليو كابسيل الآن
+
+390
+00:31:05,410 --> 00:31:14,100
+هذا الـ protein coat مش مكون من تركيب مختلفة مكون من
+
+391
+00:31:14,100 --> 00:31:21,920
+تركيب واحد متعدد إيش يعني إيه؟ monomer إيش هات
+
+392
+00:31:21,920 --> 00:31:27,340
+monomer؟ mono .. monomer يعني بروتين واحد أعطيكم
+
+393
+00:31:27,340 --> 00:31:30,560
+مثال بس عشان تخيلوا تعرفوا الـ glue؟ أكيد ياخدوكوا
+
+394
+00:31:30,560 --> 00:31:36,200
+الصغار بلعبوا معاهم لو أخذنا حفنة من الـ glue هاي و
+
+395
+00:31:36,200 --> 00:31:41,420
+رميناها على جهة و فجأة وجدناها قاعدة تتصفق فوق بعضها
+
+396
+00:31:41,420 --> 00:31:44,840
+و بتشكلي تركيبها .. أنتو إيش بتقولوا أنتو هذا
+
+397
+00:31:44,840 --> 00:31:50,700
+خيال علمي اه؟ مادة قادرة على أنها تجمع ذاتها
+
+398
+00:31:50,700 --> 00:31:57,920
+بذاتها و بمصطلح بنسميه احنا self assembly assembly
+
+399
+00:31:57,920 --> 00:32:04,440
+تجميع self assembly الآن هذا ما يحدث حقا في
+
+400
+00:32:04,440 --> 00:32:09,570
+الفيروسات الفيروسات لو احنا أخذنا المادة هذه
+
+401
+00:32:09,570 --> 00:32:12,890
+و حطيناها في test tube لحالها بدون فيروس ولا بدون
+
+402
+00:32:12,890 --> 00:32:17,450
+مادة دولارتية هتجمع لوحدها بتشكل symmetrical
+
+403
+00:32:17,450 --> 00:32:24,470
+compound وهذا شيء رائع هنتكلم عنه كمان شوية أو في
+
+404
+00:32:24,470 --> 00:32:29,310
+المحاضرة اللي جاي إن شاء الله بنه الإحساس بالحجوم
+
+405
+00:32:29,310 --> 00:32:34,960
+مهم جدا الجزء الأحمر هذا اللي شايفينه احنا هذا قطعة
+
+406
+00:32:34,960 --> 00:32:40,740
+من محيط الـ red blood cell دراسته الـ red blood cell
+
+407
+00:32:40,740 --> 00:32:45,140
+جداش حجمها؟ سبعة و نص مايكرون سبعة و نص مايكرون
+
+408
+00:32:45,140 --> 00:32:51,300
+القطر تبعها هذه السفينة الفضاء العجيبة هذي شريشا
+
+409
+00:32:51,300 --> 00:33:00,740
+كولاي جداش حجمها؟ تلاتلاف طول ب ألف قطر، الألف اللي
+
+410
+00:33:00,740 --> 00:33:03,280
+قلنالك هو واحد إيش؟ مايكرون، اللي هو الـ 1000
+
+411
+00:33:03,280 --> 00:33:08,040
+نانومتر واحد مايكرون، تطلعولي على الفيروسات، أضخم
+
+412
+00:33:08,040 --> 00:33:12,200
+فيروس على الإطلاق اسمه Ebola virus، في الأخبار
+
+413
+00:33:12,200 --> 00:33:17,300
+أكيد تسمعوا لي منها فيروس Ebola من أخطر الفيروسات
+
+414
+00:33:17,300 --> 00:33:23,140
+على كوكب الأرض وهو مولود في أفريقيا والإنسان الذي
+
+415
+00:33:23,140 --> 00:33:27,060
+يُصاب به يمكن نسبة الوفيات تصل إلى تسعين بالمائة
+
+416
+00:33:27,060 --> 00:33:32,720
+تسعين بالمائة فالنسبة القتل عنده عالية جدا ومرض
+
+417
+00:33:32,720 --> 00:33:37,760
+خطير جدا وأكبر الـ virus أو أكبر الفيروسات ومع ذلك
+
+418
+00:33:37,760 --> 00:33:41,440
+لو أخذناها لو لو لنا قدرة أنه نعمل drug and drop
+
+419
+00:33:41,440 --> 00:33:44,840
+كان سحبناها وحطيناها في الإشريشية الكولاي في في في
+
+420
+00:33:44,840 --> 00:33:48,040
+زاوية من زوايا الإشريشية الكولاي ده لا لا لا إشريشية
+
+421
+00:33:48,040 --> 00:33:53,860
+إن هو كبير اه نعم مقارنة مع مين؟ مع الفيروسات لكن
+
+422
+00:33:53,860 --> 00:33:57,560
+بالنسبة للإشريشية الكولاي صغير صلولي على فيروس الرشح
+
+423
+00:33:57,560 --> 00:34:02,720
+اللي بيحط على الماوس أنا هنا شوفينه؟ هذا ثلاثين
+
+424
+00:34:02,720 --> 00:34:06,240
+نانومتر هذا اللي .. اللي .. اللي كل سنة بيزورنا
+
+425
+00:34:06,240 --> 00:34:10,120
+مرتين ثلاثة كل واحد فينا تمام؟ ومش قادرين نتخلص
+
+426
+00:34:10,120 --> 00:34:14,840
+منه ثلاثين nanometer فقط فيه فيروسات كبيرة زي الـ
+
+427
+00:34:14,840 --> 00:34:18,560
+.. الـ variola و الـ smallpox اللي هو الجدري و الـ ..
+
+428
+00:34:18,560 --> 00:34:21,520
+الـ .. الجدري الـ .. cowpox اللي بيسموه الجدري
+
+429
+00:34:21,520 --> 00:34:24,900
+الأبقار برضه فيروس من الفيروسات الكبيرة لكن كلهم
+
+430
+00:34:24,900 --> 00:34:29,260
+لو جمعناهم يا جماعة و حاطناهم في الـ E.coli .. الـ E
+
+431
+00:34:29,260 --> 00:34:34,070
+.coli التساؤل دلالة على أنه الفيروسات صغيرة هذه
+
+432
+00:34:34,070 --> 00:34:39,530
+اللوحة أرجو أنها تكون أعطتكم إحساس بالحجوم بتاعة
+
+433
+00:34:39,530 --> 00:34:42,770
+الـ .. كل من Red blood cell اللي أنتو بتشوفوها في
+
+434
+00:34:42,770 --> 00:34:47,350
+الـ blood film كرة صغيرة صح؟ و البكتيريا بتشوفوها
+
+435
+00:34:47,350 --> 00:34:53,290
+شُحطة صغيرة فيستحيل نقدر نشوف الفيروسات under the
+
+436
+00:34:53,290 --> 00:34:57,230
+ordinary microscope بدنا electron microscope عشان
+
+437
+00:34:57,230 --> 00:34:59,210
+نقدر نشوف هذه المخلوقة
+
+438
+00:35:01,480 --> 00:35:05,760
+أنا ذكرت في التركيب قلت إنه فيه هنا الـ virus
+
+439
+00:35:05,760 --> 00:35:11,400
+بتكون من شغلتين بتكون من capsid و بتكون من مادة
+
+440
+00:35:11,400 --> 00:35:15,640
+وراثية وسميناهم nuclear capsid أنا مش قلت monomer
+
+441
+00:35:15,640 --> 00:35:20,360
+الـ monomer عشان إنه بيكون capsid سموه capsomer إذن
+
+442
+00:35:20,360 --> 00:35:25,260
+هو capsomer بيكون capsid فهمتوش الـ capsomer هو
+
+443
+00:35:25,260 --> 00:35:30,100
+monomer واحدة بناء لـ capsid كل هذا اللي سميناه
+
+444
+00:35:30,100 --> 00:35:34,060
+مع بعض وقلنا نوكليو كابسيت الـ nuclear capsule
+
+445
+00:35:34,060 --> 00:35:40,700
+طبعا في تراكيب أخرى إضافية هننتقل لها لما نتكلم عن
+
+446
+00:35:40,700 --> 00:35:46,280
+اللي هو التراكيب الأخرى في الفيروس هذا كمان بعطينا
+
+447
+00:35:46,280 --> 00:35:51,120
+إيحاء بأشكال الفيروسات المختلفة طلعوا ليه على هذا
+
+448
+00:35:53,540 --> 00:35:58,540
+عشان عامة زي في فاكهة في جنوب شرق آسيا اسمها
+
+449
+00:35:58,540 --> 00:36:02,120
+jackfruit دوروا عليها في فيلم هتلاقوها نفس
+
+450
+00:36:02,120 --> 00:36:08,020
+الشكل هذا jackfruit تمام؟ هذا شكل منتظم تماما و
+
+451
+00:36:08,020 --> 00:36:13,560
+بيسموه أشروني .. أشروني يعني عشرين أشروني الوجوه
+
+452
+00:36:13,560 --> 00:36:20,050
+أو icosa-hedral و icosa حيمرمع هتجلجوش icosahedral
+
+453
+00:36:20,050 --> 00:36:24,830
+symmetry يعني لو اللي نطلعنا هو شكله زي الكرة لكن
+
+454
+00:36:24,830 --> 00:36:29,510
+الكرة مكونة من عشرين مثلث عشرين مثلث سموها
+
+455
+00:36:29,510 --> 00:36:36,790
+icosahedral هذا حلقي spiral و عامل زي العكاز اللي
+
+456
+00:36:36,790 --> 00:36:38,390
+هو الـ إيبولا اللي شفناها قبل شوية اللي عامل زي
+
+457
+00:36:38,390 --> 00:36:46,570
+الدودة إذا فينا شكلين رئيسيين helical إيش يعني
+
+458
+00:36:46,570 --> 00:36:51,540
+helical؟ الحلزون اللولبي و icosahedral اللي يقول
+
+459
+00:36:51,540 --> 00:36:59,600
+عنه أشروني الوجوه قد نجد بعض الفيروسات تختلف تمتلك
+
+460
+00:36:59,600 --> 00:37:05,160
+شغلتين مع بعض مثلا وين
+
+461
+00:37:05,160 --> 00:37:08,900
+الـ bacterium phage كيفين الـ bacterium phage اللي
+
+462
+00:37:08,900 --> 00:37:15,850
+هنا الرأس تبعه icosahedral لكن الـ cooler في الوزن
+
+463
+00:37:15,850 --> 00:37:21,410
+هذا الفيروس helical وهذا بيسموه complex إذا ما كانش
+
+464
+00:37:21,410 --> 00:37:26,350
+icosahedral أو helical مش بيسميه complex complex
+
+465
+00:37:26,350 --> 00:37:29,890
+يعني معقد غالبا بيكون ماخد شكل غير عن الشكليين
+
+466
+00:37:29,890 --> 00:37:34,630
+التانية اللي احنا شوفناها ألخص إيش استفادنا من
+
+467
+00:37:34,630 --> 00:37:40,010
+المحاضرة هذه عرفنا إيش فيروسات كائنات حية و لا مش
+
+468
+00:37:40,010 --> 00:37:46,400
+كائنات حية لا احنا بدنا نفتي في فتوى لو لا مارسنا
+
+469
+00:37:46,400 --> 00:37:51,100
+فتوى ما فتوش فيها لحتى لو بمختلفين لا تنتلك من صفات
+
+470
+00:37:51,100 --> 00:37:55,020
+الحياة إلا قدرتها على التكاثر ومشروطة
+
+471
+00:37:55,020 --> 00:38:00,280
+intracellular ولا تنتلك DNA و RNA واحد من الثانية
+
+472
+00:38:00,280 --> 00:38:05,720
+يا إما DNA يا إما RNA المكونات تبعتها بسيطة تكاثر
+
+473
+00:38:05,720 --> 00:38:11,990
+تبعها غريب يختلف عن تكاثر المخلوقات الأخرى الحجوة
+
+474
+00:38:11,990 --> 00:38:18,070
+تبعها من 20 إلى 300 نانو متر و رأينا كيف المقارنة
+
+475
+00:38:18,070 --> 00:38:21,250
+بينها وبين الاشريكية الكولاي وما بين الورد بلود 
+
+476
+00:38:21,250 --> 00:38:26,030
+سيل شوفنا أشكال مختلفة لكن صنفنا الأشكال لثلاثة
+
+477
+00:38:26,030 --> 00:38:30,270
+الـ icosahedral, Helical و Complex هاي الثلاثة
+
+478
+00:38:30,270 --> 00:38:37,100
+أشياء اللي احنا عرفناها لحد الآن طيب ناخد جزء متعلق
+
+479
+00:38:37,100 --> 00:38:41,740
+بالمادة الوراثية لأن هذا أساسي في تصنيف الفيروسات
+
+480
+00:38:41,740 --> 00:38:44,280
+اللي معاها المادة الوراثية
+
+481
+00:38:47,000 --> 00:38:52,720
+مكونة للفيروسات إما DNA وإما RNA، الآن هذا أمر
+
+482
+00:38:52,720 --> 00:38:55,520
+سهل أن نقوله، صح هذا لأ؟ كثير سهل، إما DNA ولا
+
+483
+00:38:55,520 --> 00:38:59,620
+RNA، الآن النقطة الثانية إنه Single-Stranded أو
+
+484
+00:38:59,620 --> 00:39:04,080
+Double-Stranded، أيضًا لا يوجد في أي مخلوقات أخرى
+
+485
+00:39:04,080 --> 00:39:08,100
+أن يكون المادة اللي هو الأن Single-Stranded بس في
+
+486
+00:39:08,100 --> 00:39:11,740
+الفيروسات في single-stranded DNA و في single
+
+487
+00:39:11,740 --> 00:39:17,200
+-stranded RNA تخيلوا فإذا التصنيف بطل DNA و RNA بس
+
+488
+00:39:17,200 --> 00:39:22,800
+DNA single-stranded double-stranded RNA double
+
+489
+00:39:22,800 --> 00:39:31,540
+-stranded و single-stranded في كمان شغل ثاني الشغل
+
+490
+00:39:31,540 --> 00:39:37,260
+الثاني أن الـ RNA الـ RNA قد يكون whole RNA أو
+
+491
+00:39:37,260 --> 00:39:42,240
+segmented RNA، إيش يعني segmented؟ قطعة الـ
+
+492
+00:39:42,240 --> 00:39:45,620
+influenza virus على سبيل المثال فيها eight
+
+493
+00:39:45,620 --> 00:39:49,580
+segments المادة الوراثية تبعتها eight segments،
+
+494
+00:39:49,580 --> 00:39:53,500
+ثمان قطع عشان هي كمان لما بيجي فيروس و فيروس و
+
+495
+00:39:53,500 --> 00:39:56,880
+بيدخلوا داخل خلية، تمام؟ من نوعين مختلفين
+
+496
+00:39:56,880 --> 00:40:01,140
+الفيروسات، من صنفين مختلفين المادة الوراثية قد
+
+497
+00:40:01,140 --> 00:40:05,940
+تختلط وتروح قطعة من هذا الـ virus لمن؟ لـ virus آخر،
+
+498
+00:40:05,940 --> 00:40:10,580
+هذا الـ virus الآخر بيمتلك الآن صفات جديدة، هذه
+
+499
+00:40:10,580 --> 00:40:17,150
+الصفات الجديدة منها أن جينات فلابدوا لأن على
+
+500
+00:40:17,150 --> 00:40:24,070
+أجسامنا تمام هذه الفيروسات كإنها فيروسات جديدة 
+
+501
+00:40:24,070 --> 00:40:28,990
+جسمنا ما بتعرف عليها إنها أصابع تساجقك وبالتالي
+
+502
+00:40:28,990 --> 00:40:34,210
+يحدث مرض لدينا هذا واحد، اثنان قد تمتلك بعض عوامل
+
+503
+00:40:34,210 --> 00:40:39,830
+الشراسة الجديدة تسمعوا بإنفلوانزا الطيور؟ الإنفلوانزا 
+
+504
+00:40:39,830 --> 00:40:46,090
+الطيور، نسبة القتل فيها وصلت ل 65%، انتشارها 
+
+505
+00:40:46,090 --> 00:40:50,130
+ضعيف، يعني كل اللي أصابتهم لحد الآن حول العالم من
+
+506
+00:40:50,130 --> 00:40:54,650
+سبع سنوات أو ثمان سنوات، لها دلوقت ثلاث تلف، لكن
+
+507
+00:40:54,650 --> 00:40:59,470
+الثلاث تلف شخص اللي أصيبه أكثر من نصفهم ماتوا، يبقى
+
+508
+00:40:59,470 --> 00:41:04,170
+عموما شراسة قوية جدا في هذا الفيروس غير موجود فيه
+
+509
+00:41:04,170 --> 00:41:07,690
+نحن بنصاب بالإنفلوانزا العادية باستمرار و دلوقت ..
+
+510
+00:41:07,690 --> 00:41:08,890
+أو .. أو .. أو .. أو .. أو .. أو .. أو .. أو .. أو
+
+511
+00:41:08,890 --> 00:41:11,770
+.. أو .. أو .. أو .. أو .. أو .. أو .. أو .. أو ..
+
+512
+00:41:11,770 --> 00:41:12,210
+أو .. أو .. أو .. أو .. أو .. أو .. أو .. أو .. أو
+
+513
+00:41:12,210 --> 00:41:16,410
+أو .. أو .. أو ..
+
+514
+00:41:16,410 --> 00:41:20,650
+أو ..
+
+515
+00:41:30,110 --> 00:41:34,830
+غالبا الذين يموتون من الـ influenza هم من كبار السن
+
+516
+00:41:34,830 --> 00:41:39,470
+كلمة كبار السن غالبا مثلا في دولة زي اليابان
+
+517
+00:41:39,470 --> 00:41:48,070
+المتوسط الـ life expectancy صار فوق السبعين، صار فوق
+
+518
+00:41:48,070 --> 00:41:55,410
+السبعين، فبنلاقي نسبة كبيرة من الناس في هذه الفئة،
+
+519
+00:41:55,410 --> 00:42:00,590
+الفئة مين؟ الـ very old age وبالتالي هم هدول الناس
+
+520
+00:42:00,590 --> 00:42:03,990
+اللي دي أكثر ناس ممكن يصابوا بيه أو يموتوا من
+
+521
+00:42:03,990 --> 00:42:09,270
+أمراض مثل اللي هو الـ influenza، لكن بشكل عام المادة
+
+522
+00:42:09,270 --> 00:42:15,410
+الوراثية المجزأة تسهل عملية تبادل القطع وبالتالي
+
+523
+00:42:15,410 --> 00:42:19,970
+في أنحاء اسمها Antigenic Variation، Antigenic
+
+524
+00:42:19,970 --> 00:42:23,670
+Variation يعني إيه؟ التغير الجيني من سلالة إلى
+
+525
+00:42:23,670 --> 00:42:30,150
+سلالة أخرى، وهذا يعطي أفضلية للفيروس في أنه يحدث
+
+526
+00:42:30,150 --> 00:42:33,930
+دائما اللي هو العمل دي كمان نقطة كتير مهمة
+
+527
+00:42:34,570 --> 00:42:40,630
+الفيروسات تنتقل نسخة واحدة من المادة الوراثية داخل
+
+528
+00:42:40,630 --> 00:42:45,630
+النوكليوكابسي، نسخة واحدة زي الخلايا الجنسية عند
+
+529
+00:42:45,630 --> 00:42:50,930
+الإنسان، كم .. كم كروموزومي احنا؟ 46 مظبوط، لكن
+
+530
+00:42:50,930 --> 00:42:59,470
+البويضة؟ 23، الـ sperm؟ 23، فالفيروسات تنتقل نسخة
+
+531
+00:42:59,470 --> 00:43:01,870
+واحدة، إيش بنسمي النسخة الواحدة احنا في الوراثة؟
+
+532
+00:43:03,510 --> 00:43:07,450
+لما يكونوا ينتهوا يسميها deployed يا هل تلاقي فيه
+
+533
+00:43:07,450 --> 00:43:11,350
+فيروسات عندها deployed؟ نعم فيه فيروسات عندها
+
+534
+00:43:11,350 --> 00:43:16,890
+deployed لكن استثناء يعني فيروس واحدة اللي بنعرفه
+
+535
+00:43:16,890 --> 00:43:22,670
+اللي هو الـ HIV، الفيروس الـ AIDS فيه نسختين من
+
+536
+00:43:22,670 --> 00:43:24,530
+المادة الوراثية
+
+537
+00:43:28,940 --> 00:43:31,240
+طيب، الملخص لأن المادة الوراثية بالنسبة لي كتير
+
+538
+00:43:31,240 --> 00:43:38,240
+مهمة في الـ .. في الـ .. في الفيروسات، عندي الفيروس
+
+539
+00:43:38,240 --> 00:43:45,560
+يختلف عن الخلايا بأنه يحتوي يا إما DNA يا إما RNA
+
+540
+00:43:45,560 --> 00:43:49,780
+يعني الـ DNA و الـ RNA، بطل DNA أو RNA عادي، يا إما
+
+541
+00:43:49,780 --> 00:43:53,340
+double-stranded يا إما single-stranded، و single
+
+542
+00:43:53,340 --> 00:43:58,920
+-stranded يا إما whole يا إما segmented، و مرة أخرى
+
+543
+00:43:58,920 --> 00:44:03,540
+الجينوم ككل ممكن يكون haploid و ممكن يكون diploid
+
+544
+00:44:03,540 --> 00:44:07,100
+و المرة الجاية إن شاء الله بنكمل في نفس السياق
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8166bc529c5fce382d50f8ad4835c27c0fc56ba2
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA_postprocess.srt
@@ -0,0 +1,2176 @@
+1
+00:00:20,870 --> 00:00:22,790
+بسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:22,790 --> 00:00:26,370
+الصلاة والسلام على سيدنا محمد وعلى آله وصحبه ومن
+
+3
+00:00:26,370 --> 00:00:30,570
+ساعده ربيع الأعمال الدين كل عام وانتم بخير بمناسبة
+
+4
+00:00:30,570 --> 00:00:33,690
+بدء الفصل الدراسي الجديد وان شاء الله يكون عام خير
+
+5
+00:00:33,690 --> 00:00:38,950
+وجد واجتهاد ونجاح بإذن الله مصاق اللي هندرسه مع
+
+6
+00:00:38,950 --> 00:00:42,280
+بعض ان شاء الله اليوم اللي هو ال biologyو الحقيقة
+
+7
+00:00:42,280 --> 00:00:46,940
+انكم محظوظين انكم درستم essential و medical
+
+8
+00:00:46,940 --> 00:00:50,520
+microbiology سابقا لهذا ال course لأنه كتير من
+
+9
+00:00:50,520 --> 00:00:54,400
+المعلومات المذكورة في هذا المصاد ستجدوا انكم
+
+10
+00:00:54,400 --> 00:01:00,610
+بتعرفوها مسبقا ان شاء اللهقبل ما ابدأ بعرض مفارضات
+
+11
+00:01:00,610 --> 00:01:07,230
+المساق بنحاول نشوف اللي هو course outline او ال
+
+12
+00:01:07,230 --> 00:01:12,030
+course syllabus طبعا بتعرفوني عبدالروف المنعمة
+
+13
+00:01:12,030 --> 00:01:19,860
+مدرسكم السابق المساق اسمه virologyو العدد الساعات
+
+14
+00:01:19,860 --> 00:01:24,220
+المعتبدة هو ثلاث ساعات فقط لغير ال course number
+
+15
+00:01:24,220 --> 00:01:30,980
+ميدي تلاتة تلاتة خمسة أربع الساعات اللي بنلتقي
+
+16
+00:01:30,980 --> 00:01:34,160
+فيها ان شاء الله هي من التاسعة إلى العشرة سبت
+
+17
+00:01:34,160 --> 00:01:37,860
+اثنين اربعاء في هذه القاعة اللي هي الان M601
+
+18
+00:01:39,840 --> 00:01:43,760
+ال website الخاص بيه انا برضه بتعرفوه موجود على
+
+19
+00:01:43,760 --> 00:01:46,620
+المحاضرة ان شاء الله ال email تبعي انا و بفضل
+
+20
+00:01:46,620 --> 00:01:50,220
+وسيلة التواصل اما على ال facebook او على ال email
+
+21
+00:01:50,220 --> 00:01:54,540
+يعني اكثر من هاتف او زيارة حتى المكتب مع انه
+
+22
+00:01:54,540 --> 00:01:58,780
+هتخصكوا ان شاء الله ساعات مكتبية بالنسبالي اللي هي
+
+23
+00:01:58,780 --> 00:02:03,500
+الغالبا بعد المحاضرة من ال 11 من العشرة ال 11 سبت
+
+24
+00:02:03,500 --> 00:02:06,080
+اتنين اربعة ساعات مكتبية بتكونوا فاضين فيها ولا
+
+25
+00:02:06,080 --> 00:02:13,470
+مشغولين؟ مشغولين؟من ال 11 ل 12 برضه فرق خلاص ممكن
+
+26
+00:02:13,470 --> 00:02:18,790
+نمدها من العشرة ل 12 ان شاء الله العشرة ل 12 طبعا
+
+27
+00:02:18,790 --> 00:02:23,910
+المكتب يقنع الجديد في الطابق التالت في مبنى العلوم
+
+28
+00:02:23,910 --> 00:02:28,210
+الطبية المخبرية في قسم التحيط الطبية يعني بقرب من
+
+29
+00:02:28,210 --> 00:02:32,730
+مكاتب الأساتذة في القسم ان شاء اللهبالنسبة لل
+
+30
+00:02:32,730 --> 00:02:37,570
+facebook group مننا group لكم اسمها Virology 201،
+
+31
+00:02:37,570 --> 00:02:42,250
+201 على رقم الشعب اللي أنتوا تسجلين فيها، لو فت ..
+
+32
+00:02:42,250 --> 00:02:45,650
+لو فتحتوا عليها اليوم ان شاء الله و عملتوا انضمام،
+
+33
+00:02:45,650 --> 00:02:49,050
+طلب انضمام، هتلاقوا المحاضرة اللي معانا الآن
+
+34
+00:02:49,050 --> 00:02:51,570
+موجودة و ال course outline أو ال course syllabus
+
+35
+00:02:51,570 --> 00:02:56,760
+أيضا هتلاقوه ان شاء الله موجودبالنسبة ل الكتاب هو
+
+36
+00:02:56,760 --> 00:03:00,220
+كتاب عالم مشهور اسمه a review of medical
+
+37
+00:03:00,220 --> 00:03:05,160
+microbiology and immunology و ال .. ال .. حيكون
+
+38
+00:03:05,160 --> 00:03:10,320
+ضمن المساقن ان شاء الله flashات و صور و فيديوهات
+
+39
+00:03:10,320 --> 00:03:14,040
+ان شاء الله هنزودكم فيها او روابط لها حتى تحضروها
+
+40
+00:03:14,040 --> 00:03:16,740
+و تستفيدوا منها ان شاء اللهبالنسبة للدرجات و هذا
+
+41
+00:03:16,740 --> 00:03:21,700
+الموضوع اللى بهمكوا كتير الامر كالعادى يعنى ال
+
+42
+00:03:21,700 --> 00:03:26,540
+midterm عادي 25 درجة ال final exam 60 درجة ال
+
+43
+00:03:26,540 --> 00:03:30,780
+attendance خمس درجات و ال quizzes عشر درجات و لو
+
+44
+00:03:30,780 --> 00:03:33,860
+مااخدناش ال quizzes هنضم العشرة درجات للمين لل
+
+45
+00:03:33,860 --> 00:03:35,360
+midterm ان شاء الله لل midterm
+
+46
+00:03:38,090 --> 00:03:43,190
+محتوى المساق محتوى غزير ومحتوى رائع جدا وانا اود
+
+47
+00:03:43,190 --> 00:03:48,550
+ان اقدم يعني تقديم بسيط لهذا المساق يمكن من اضعف
+
+48
+00:03:48,550 --> 00:03:55,070
+النقاط في مجال التحليل الطبية في قطاع غزة ومجال ال
+
+49
+00:03:55,070 --> 00:04:01,430
+virusلماذا أضعف النقطة؟ لأن التكلفة تبع الزراعة
+
+50
+00:04:01,430 --> 00:04:07,250
+تحت الفيروسات عالية وغير متوفرة في معظم المؤسسات
+
+51
+00:04:07,250 --> 00:04:11,110
+الصحية، حتى الجامعات ومنها جامعتنا، فقط بنوفرها
+
+52
+00:04:11,110 --> 00:04:16,510
+لما نمل دراسة، ولكن ليس على شكل روتيني، وبالتالي
+
+53
+00:04:16,510 --> 00:04:20,730
+نحن بحاجة إلى تطوير هذا المجالولا يمكن أن نطول هذا
+
+54
+00:04:20,730 --> 00:04:24,990
+المجال فقط بشراء أجهزة ومعدات ومواد وإنما يجب أن
+
+55
+00:04:24,990 --> 00:04:27,930
+نطول الكوادر البشرية اللي هي مثل حضراتكم فهذا
+
+56
+00:04:27,930 --> 00:04:31,410
+المثاق هيجتمل ان شاء الله على كام كبير من
+
+57
+00:04:31,410 --> 00:04:34,870
+المعلومات صحيح بصعب .. بصعب عليكم في الامتحان لكن
+
+58
+00:04:34,870 --> 00:04:39,110
+الآخر بيطلن منها وناس مؤهلين بشكل جيد ان شاء الله
+
+59
+00:04:39,110 --> 00:04:43,350
+أنا قسمت المثاق إلى قسمين قسم part one و part two
+
+60
+00:04:43,350 --> 00:04:46,950
+part one هو ال basic virology و ال part two هو ال
+
+61
+00:04:46,950 --> 00:04:51,490
+clinical virologyطبعا ال basic صعب علينا نتكلم عن
+
+62
+00:04:51,490 --> 00:04:56,190
+طب و عن أمراض فيروسية دون أننا نعرف التفاصيل عن
+
+63
+00:04:56,190 --> 00:05:00,370
+الفيروسات و صفاتها و تركيبها و طريقة تكاثرها
+
+64
+00:05:00,370 --> 00:05:03,770
+بالضبط زي ما أخدنا في البكتيريا أخدنا essential و
+
+65
+00:05:03,770 --> 00:05:05,870
+medical و بعدين أخدنا diagnostic و micro و اقبل
+
+66
+00:05:05,870 --> 00:05:09,790
+فانا فيه basic virology ال structure تبع الفيروسات
+
+67
+00:05:09,790 --> 00:05:13,310
+ال replication و ال replication تبع الفيروس أصلا
+
+68
+00:05:13,310 --> 00:05:15,950
+بميزه عن باقي المخلوقات و هنتكلم عنه بعد قليل
+
+69
+00:05:16,620 --> 00:05:19,620
+Genetic and gene therapy، يا هل ترى الفيروسات
+
+70
+00:05:19,620 --> 00:05:24,060
+يحكمها نفس ما يحكم البكتيريا والإنسان من مادة
+
+71
+00:05:24,060 --> 00:05:29,500
+وراثية ونظم للوراثة، هذا ما سنتعرف عليه إن شاء
+
+72
+00:05:29,500 --> 00:05:32,540
+الله في هذا الفصل Classification of medically
+
+73
+00:05:32,540 --> 00:05:38,680
+important virusesزي ما في بكتيريا مفيدة و بكتيريا
+
+74
+00:05:38,680 --> 00:05:42,500
+ضارة و زي ما في بكتيريا ممرضة و بكتيريا محتملها
+
+75
+00:05:42,500 --> 00:05:46,480
+تكون ممرضة، أيضا البيروسات لا نستطيع أن نقول عنها
+
+76
+00:05:46,480 --> 00:05:50,600
+كلها medically important، في كتير منها بالعكس
+
+77
+00:05:50,600 --> 00:05:54,300
+medically important من ناحية عكسية، نحن نستخدمها
+
+78
+00:05:54,300 --> 00:05:57,420
+في قتل البكتيريا، على سبيل المثال زي ال
+
+79
+00:05:57,420 --> 00:06:02,480
+bacteriophagesيعني مثلا كعلاج مش كفيه فيروسات
+
+80
+00:06:02,480 --> 00:06:05,640
+بتصيبش الإنسان بتصيب الحيوان فيه بتصيبش الإنسان
+
+81
+00:06:05,640 --> 00:06:09,300
+والحيوان فيه بتصيب النباتات وبتالي فيه فيروسات
+
+82
+00:06:09,300 --> 00:06:16,380
+بالفعل لاتهمن سريريا أو طبيا هذا الفيروس الذي
+
+83
+00:06:16,380 --> 00:06:20,820
+نختلف على ما إذا كان أصلا كائن حي أو غير كائن حي
+
+84
+00:06:22,900 --> 00:06:28,600
+كيف له أن يحدث مرض للإنسان؟ ما الذي يؤهله؟ ما هي
+
+85
+00:06:28,600 --> 00:06:32,900
+مكوناته؟ ما هي جيناته؟ ما هي إنزيماته؟ كيف له أن
+
+86
+00:06:32,900 --> 00:06:38,510
+يحدث مرض؟ هذا بيسميه pathogenesisكيف لرسم الإنسان
+
+87
+00:06:38,510 --> 00:06:42,050
+أن يتقي هذا الفيروس و أن يكافحه و أن هثير بالمرض
+
+88
+00:06:42,050 --> 00:06:47,190
+بال influenza وهي فيروس و بالرشح وهي فيروس و نشفى
+
+89
+00:06:47,190 --> 00:06:51,370
+تلقائيا دون ما تدخل علاجي يبقى في عندنا host
+
+90
+00:06:51,370 --> 00:06:55,530
+defense يعني في عندنا مناعة ضد الفيروسات كيف لهذه
+
+91
+00:06:55,530 --> 00:06:59,710
+المناعة أو كيف تعمل هذه المناعةالـ laboratory
+
+92
+00:06:59,710 --> 00:07:04,250
+diagnosis تشخيص المخبري للفيروسات قاعدين نتكلم على
+
+93
+00:07:04,250 --> 00:07:08,990
+ضعف شديد في هذا المجال antiviral drugs و أنا سأكون
+
+94
+00:07:08,990 --> 00:07:13,630
+يعني خفيف معاكم في هذا الجانب لإنه كام من العقاقير
+
+95
+00:07:13,630 --> 00:07:19,410
+عالي جدا و أسماءها صعبة فهنكتفي في غالبا بأسماء
+
+96
+00:07:19,410 --> 00:07:24,550
+العائلات تبع هذه العقاقير الوصول الأخير من ال part
+
+97
+00:07:24,550 --> 00:07:30,340
+one اللي هو ال viral vaccinesيعني شرر الأطفال أعلن
+
+98
+00:07:30,340 --> 00:07:33,880
+قبل عامين أن فلسطين خالية من شرر الأطفال من قبل
+
+99
+00:07:33,880 --> 00:07:38,260
+مرضى الصحة العالمية شرر الأطفال مرض فيروسي كيف
+
+100
+00:07:38,260 --> 00:07:42,980
+تخلص العالم من هذا المرض الفيروسي من خلال التطعمات
+
+101
+00:07:42,980 --> 00:07:47,700
+اللي هي ال vaccines بتسمعوا بال smallpox smallpox
+
+102
+00:07:47,700 --> 00:07:50,760
+اللي هو الجدري مش الجدري اللي بتعرفوه انتوا جدر
+
+103
+00:07:50,760 --> 00:07:56,340
+الماء أو بيسموه chickenpox لأ هذا جدري
+
+104
+00:07:57,160 --> 00:08:02,180
+تم القضاء عليه ايضا من خلال من خلال تطعيمات و
+
+105
+00:08:02,180 --> 00:08:06,340
+تطعيمات كانت فعالة جدا لدرجة انه بالفعل اخر حالة
+
+106
+00:08:06,340 --> 00:08:10,600
+سجلت كانت في العام الف وتسعمائة وتسعة وسبعين لمريض
+
+107
+00:08:10,600 --> 00:08:15,660
+سوداني اصيب بهذا المرض الخبيث و تم القضاء عليه اذا
+
+108
+00:08:15,660 --> 00:08:20,840
+ال viral vaccines مهمة جدا جدا في عملية التخلص
+
+109
+00:08:20,840 --> 00:08:25,860
+منها من الأمراض الفيروسية ال part two هلاجي اول
+
+110
+00:08:25,860 --> 00:08:30,760
+اربع عنوينDNA envelope viruses DNA non envelope
+
+111
+00:08:30,760 --> 00:08:36,060
+viruses RNA envelope وRNA non envelope ايش التصنيف
+
+112
+00:08:36,060 --> 00:08:41,020
+هذه العجيبة؟ عندنا تصنيف للمادة الوراطية الفيروسات
+
+113
+00:08:41,020 --> 00:08:47,580
+يا جماعة يا اما DNA يا اما RNA لكن ليس كلاهما
+
+114
+00:08:47,580 --> 00:08:53,440
+لايوجد داخل الفيروس اتنيناللي هم ال DNA و ال RNA،
+
+115
+00:08:53,440 --> 00:08:57,100
+يا إما RNA يا إما DNA، و أصلا لا يوجد في الدنيا
+
+116
+00:08:57,100 --> 00:09:01,440
+مخلوقات بنعرفها المادة الوراثية تبعتها RNA إلا من؟
+
+117
+00:09:01,440 --> 00:09:06,460
+إلا الفيروس، اللي أنا صففنا based on DNA أو RNA،
+
+118
+00:09:06,460 --> 00:09:12,560
+في كمان تصنيف، في بعض الفيروسات تنتلك envelopeغلاف
+
+119
+00:09:12,560 --> 00:09:17,300
+خارجي تمام؟ بنسميه envelope فاللي تمتلك هذا الغلاف
+
+120
+00:09:17,300 --> 00:09:21,420
+بنسميها enveloped واللي ما تمتلكه بنسميها non
+
+121
+00:09:21,420 --> 00:09:27,140
+-enveloped أو nakedتمام؟ يا اما naked يا اما non
+
+122
+00:09:27,140 --> 00:09:30,080
+-enveloped فالان بالظبط زي ما كنا في البكتيريا
+
+123
+00:09:30,080 --> 00:09:32,800
+نقول gram positive و gram negative و نقول بصي لاي
+
+124
+00:09:32,800 --> 00:09:37,040
+و نقول كوكساي هلق نقول DNA viruses يا اما
+
+125
+00:09:37,040 --> 00:09:40,180
+enveloped يا اما non-enveloped RNA enveloped او
+
+126
+00:09:40,180 --> 00:09:44,940
+non-enveloped إذا تصنيفة سهلة لهذه الفيروسات انا
+
+127
+00:09:44,940 --> 00:09:48,560
+كمان مجموعة مهمة جدا من الفيروسات تسمى Hepatitis
+
+128
+00:09:48,560 --> 00:09:55,580
+virusesلا تمتلك مقومات الشراكة في مجموعة إلا مقوم
+
+129
+00:09:55,580 --> 00:10:00,260
+واحد، إيش هو هذا المقوم؟ إنها كلها بتصيب الكبد،
+
+130
+00:10:00,260 --> 00:10:04,080
+يعني ال target تبعها الكبد، أعطيكوا أمثلة،
+
+131
+00:10:04,080 --> 00:10:09,980
+Hepatitis A تختلف تقريبا عن B تختلف تقريبا عن C،
+
+132
+00:10:09,980 --> 00:10:14,110
+في ال structure و في العائلةلكن بنسميها Hepatitis
+
+133
+00:10:14,110 --> 00:10:17,970
+A و Hepatitis B و Hepatitis C لإن كلهم بيشتركوا
+
+134
+00:10:17,970 --> 00:10:22,430
+بيصيبوا مين اللي هو الكلمة طبعا هم صاروا ستة الآن
+
+135
+00:10:22,430 --> 00:10:28,030
+Hepatitis A و B و C و D أو Delta و فيه هنا E و فيه
+
+136
+00:10:28,030 --> 00:10:31,710
+هنا G يبقى فيه هنا مجموعة كبيرة من الفيروسات
+
+137
+00:10:31,710 --> 00:10:37,010
+سميناهم Hepatitis Virus في مجموعة أخرى كمان مهمة
+
+138
+00:10:37,010 --> 00:10:41,680
+اسمها Arboviruses و Arbo جاية من كلمةأرثروبود
+
+139
+00:10:41,680 --> 00:10:45,400
+والأرثروبود مرض عليكم قبل هيك مفصليات الأرض
+
+140
+00:10:45,400 --> 00:10:52,960
+الحشرات يعني و بو born ف ar اللي هى r هدى عبارة عن
+
+141
+00:10:52,960 --> 00:11:00,600
+أرثرو والجندل بي وال او هى من born كلمة born لما
+
+142
+00:11:00,600 --> 00:11:03,740
+نقول food born diseases الأمراض المنتقلة عن طريق
+
+143
+00:11:03,740 --> 00:11:09,050
+الغذاءأرثروبود born diseases الأمراض المنتقلة عن
+
+144
+00:11:09,050 --> 00:11:14,150
+طريق الحشرات، أربو فيروسات هي فيروسات تنتقل عن
+
+145
+00:11:14,150 --> 00:11:19,470
+طريق من الحشرات، تسمعوا أن الفيروسات بتسبب سرطان؟
+
+146
+00:11:20,300 --> 00:11:24,000
+مين هدول معانا اليوم الدراسة اللي عملناها لل .. لل
+
+147
+00:11:24,000 --> 00:11:28,740
+.. السرطان؟ أنا عملت محاضرة وتحدثت على إن ما نسبته
+
+148
+00:11:28,740 --> 00:11:33,320
+حوالي عشرين بالمائة من السرطانات اللي بتصيب البشر
+
+149
+00:11:33,320 --> 00:11:39,800
+سببها micro organismبكتيريا او فيروسات او طوفيليات
+
+150
+00:11:39,800 --> 00:11:45,600
+الناس بلا بأس بها من السرطانات تحدثها micro
+
+151
+00:11:45,600 --> 00:11:49,180
+organism منها الفيروسات هذه الفيروسات احنا بنسميها
+
+152
+00:11:49,180 --> 00:11:54,920
+tumor viruses يعني الفيروسات التي تنتج الأورامل
+
+153
+00:11:54,920 --> 00:11:59,360
+ومن ضمن هذه الأورامل هي السرطانة في مجموعة أخرى
+
+154
+00:11:59,360 --> 00:12:05,000
+اسمها slowviruses and prions كلمة slow viruses
+
+155
+00:12:05,000 --> 00:12:11,860
+توحي بأن الفيروس بطيء أو المرض اللي يسببه الفيروس
+
+156
+00:12:11,860 --> 00:12:16,660
+بيعمل slow progression يعني تقدمه في الإنسان بيكون
+
+157
+00:12:16,660 --> 00:12:21,220
+بطيء بده سنوات حتى يحدث هذا المرض هذا الشق الأول
+
+158
+00:12:21,220 --> 00:12:25,220
+من الموضوع الشق التاني اللي هي ال prions ال prions
+
+159
+00:12:25,220 --> 00:12:30,110
+يا بنات احنا يعني لما زمان زمانجابل الميكروسكوبات
+
+160
+00:12:30,110 --> 00:12:33,510
+الشيء الوحيد اللي كنا نعرفه انه parasite هو
+
+161
+00:12:33,510 --> 00:12:36,750
+الحشرات الكبيرة زي الجمل اللي كنا نشوفها اما على
+
+162
+00:12:36,750 --> 00:12:41,730
+الرأس او على الاسم طورنا شوية صار ان الميكروسكوبات
+
+163
+00:12:41,730 --> 00:12:46,150
+صاروا ناعرة في ال bacteria لما اكتشفنا ال virus
+
+164
+00:12:46,150 --> 00:12:51,870
+كانت نقلة نوعية في المعارفة البشرية ان في مخلوقات
+
+165
+00:12:51,870 --> 00:12:57,140
+اصغر من مين من ال bacteriaفي تسينات القرن الماضي
+
+166
+00:12:57,140 --> 00:13:04,020
+اكتشفنا ان في اصلا مادة معضية ليس لها اي خصائص
+
+167
+00:13:04,020 --> 00:13:08,800
+حياة ليه ال bryons اللي بتسبب مرض جنون البقر
+
+168
+00:13:08,800 --> 00:13:16,540
+بالمناسبة في مرض جنون البشر يعني المقابل له ال
+
+169
+00:13:16,540 --> 00:13:20,620
+bryons عبارة عن مجموعة من البروتينات normally
+
+170
+00:13:20,620 --> 00:13:25,230
+found in our bodies يعني مولودة فينا احنابس بتكون
+
+171
+00:13:25,230 --> 00:13:31,650
+normal ونفترض شكلها هيك هذا normal إذا اتحول إلى
+
+172
+00:13:31,650 --> 00:13:37,550
+شكل آخر بتصير abnormal كيف تتكاتر هذه ال abnormal
+
+173
+00:13:37,550 --> 00:13:43,810
+بيلتقي مع ال normal بيخليه abnormal بمعنى آخر هو
+
+174
+00:13:43,810 --> 00:13:48,480
+بتكاترش تكاتر فعلي وإنما بيحولالـ Normal إلى
+
+175
+00:13:48,480 --> 00:13:52,360
+Abnormal فبكتر من مين؟ من الـ Abnormal وكانوا قاعد
+
+176
+00:13:52,360 --> 00:13:57,820
+بتكاتر وهذا اسمه protein infectious واقتصرناهم
+
+177
+00:13:57,820 --> 00:14:02,760
+واسميناهم Prions إذن الـ Prions هي ليست مخلوقات
+
+178
+00:14:02,760 --> 00:14:07,100
+حية وإنما مخلوقات غير حية هي عبارة عن protein لا
+
+179
+00:14:07,100 --> 00:14:13,380
+تحتوي على مادة وراثية ألبس النقطة
+
+180
+00:14:13,380 --> 00:14:18,520
+اللي بعديها Human Immunodeficiency Virusاللي هو
+
+181
+00:14:18,520 --> 00:14:23,220
+مرض أو فيروس عواز المناع أو نقص المناع اللي هو ال
+
+182
+00:14:23,220 --> 00:14:27,740
+aids فيروس ال aids وكلكم
+
+183
+00:14:27,740 --> 00:14:32,800
+بتعرفوا أن هذا الفيروس منذ اكتشافه أجريت عليه
+
+184
+00:14:32,800 --> 00:14:37,120
+دراسات عديدة لدرجة أن هذه الدراسات كانلها أثر كبير
+
+185
+00:14:37,120 --> 00:14:41,980
+في تطور علم ال biology وعلم ال immunology بشكل عام
+
+186
+00:14:43,340 --> 00:14:46,400
+على الرغم ان احنا لحد دلان مااتشفناش علاج فعال
+
+187
+00:14:46,400 --> 00:14:52,780
+للفيروس يعني في علاجات لكن مش ناجعة تماما في
+
+188
+00:14:52,780 --> 00:14:58,520
+القضاء عليه ولا قدرنا نحصل vaccine يمنع حدوث هذا
+
+189
+00:14:58,520 --> 00:15:02,440
+المرض إلا أن الدراسات المصاحبة بالفعل سهمت في
+
+190
+00:15:02,440 --> 00:15:07,730
+تطوير علم المناعة وعلم الفيروسةو طبعا بتعرفوا كل
+
+191
+00:15:07,730 --> 00:15:11,150
+سنة بيحتفلوا بيوم ال .. بيوم ال aids العالمي دلالة
+
+192
+00:15:11,150 --> 00:15:16,330
+على أن هذا المرض ما زال بيحتل مكانة كبيرة في الطب
+
+193
+00:15:16,330 --> 00:15:19,570
+في العالم والنقطة الأخيرة إذا أسعفنا الوقت اللي هي
+
+194
+00:15:19,570 --> 00:15:23,530
+ال minor viral pathogen كلمة minor viral pathogen
+
+195
+00:15:23,530 --> 00:15:30,150
+مصطلح فاضفاض ليس مصطلح دقيق فبنحاول نفسرلكم إيه ما
+
+196
+00:15:30,150 --> 00:15:34,810
+المقصود فيه لو عرفنا أنه منطقة ما جغرافية في
+
+197
+00:15:34,810 --> 00:15:39,830
+العالمبيحدث فيها وباء بفيروس محدد ولا ينتقل هذا
+
+198
+00:15:39,830 --> 00:15:45,290
+الفيروس إلى أي دولة تانية هذا بيعتبره minor بيحصل
+
+199
+00:15:45,290 --> 00:15:51,030
+مثلا كل عشرين سنة وباء محدود بيسموه minor لكن ما
+
+200
+00:15:51,030 --> 00:15:55,870
+رأيكم باسم West Nile Virus West Nile حمال نيل
+
+201
+00:15:55,870 --> 00:16:00,430
+الغربي صح؟ ايش يعني حمال نيل الغربي؟ يعني حمى
+
+202
+00:16:00,430 --> 00:16:06,200
+اكتشفوها في منطقات حوض النيل الغربيطب هاد ال .. ال
+
+203
+00:16:06,200 --> 00:16:07,840
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+204
+00:16:07,840 --> 00:16:08,020
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+205
+00:16:08,020 --> 00:16:08,060
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+206
+00:16:08,060 --> 00:16:08,320
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+207
+00:16:08,320 --> 00:16:08,340
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+208
+00:16:08,340 --> 00:16:14,220
+ال .. ال .. ال ..
+
+209
+00:16:14,220 --> 00:16:19,320
+ال ..
+
+210
+00:16:19,320 --> 00:16:19,340
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+211
+00:16:19,340 --> 00:16:19,620
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+212
+00:16:19,620 --> 00:16:19,940
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+213
+00:16:19,940 --> 00:16:20,160
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+214
+00:16:20,160 --> 00:16:31,700
+.. ال .. ال ..
+
+215
+00:16:32,620 --> 00:16:37,320
+التغير المناخي اللي حاصل في العالم بلدان كانت أصلا
+
+216
+00:16:37,320 --> 00:16:41,680
+حارة اليوم صارت معتدلة انت بتعرف ان بريطانيا زرع
+
+217
+00:16:41,680 --> 00:16:46,800
+فيها زيتون قبل كام سنة نجحها في زراعة زيتون طبعا
+
+218
+00:16:46,800 --> 00:16:49,620
+الزيتون كان حلم ان ينزلها في وين في بريطانيا انه
+
+219
+00:16:49,620 --> 00:16:53,080
+يعني هو بنزلها بس مافيحملش ثمر يعني فالقصد من
+
+220
+00:16:53,080 --> 00:16:57,200
+الكلام احنا في غزة هنا أصبح لدينا أنواع من البعوض
+
+221
+00:16:57,200 --> 00:17:02,270
+لم نكن نعرفها من قبل سموها tiger mosquitoاللي
+
+222
+00:17:02,270 --> 00:17:06,610
+بتكون مخططة زي ال .. و لساعتها مزعجة جدا اعتقد
+
+223
+00:17:06,610 --> 00:17:10,590
+بيسموها Aedes Aegypticus او الزعجة المصرية يعني هي
+
+224
+00:17:10,590 --> 00:17:18,310
+بعوضة من مصر هذا التغير في المناخ و سهولة السفر
+
+225
+00:17:18,310 --> 00:17:23,170
+أصبح او جعل من إمكانية انتقال الأمراض من مكان
+
+226
+00:17:23,170 --> 00:17:28,300
+جغرافي إلى آخر إمكانية عاليةكلمة minor الآن هي
+
+227
+00:17:28,300 --> 00:17:32,860
+minor لكن في المستقبل قد تكون major ومنتشرة بشكل
+
+228
+00:17:32,860 --> 00:17:37,160
+كام طيب
+
+229
+00:17:37,160 --> 00:17:43,020
+.. الآن مانفعش أنه ندخل على الفيروسات وعلى الطب
+
+230
+00:17:43,020 --> 00:17:47,420
+تبع الفيروسات دون ما معرفة ماهي .. ماهية
+
+231
+00:17:47,420 --> 00:17:54,390
+الفيروسات، بنتفق عليها تماماأول نقطة أساسية تميز
+
+232
+00:17:54,390 --> 00:17:58,110
+الفيروسات عن باقي المخلوقات their obligate
+
+233
+00:17:58,110 --> 00:18:02,810
+intracellular replication حد هيقوللي دارس
+
+234
+00:18:02,810 --> 00:18:05,210
+diagnostic microbial يقوللي دكتور ماحنا درسنا
+
+235
+00:18:05,210 --> 00:18:10,290
+تنتين بكتيريا الكلاميديا والريكيزيا التنتين
+
+236
+00:18:10,290 --> 00:18:13,770
+obligate intracellular برضة كلامكوا صحيح هذا وجه
+
+237
+00:18:13,770 --> 00:18:18,630
+التشابه الوحيد بين هدول التنتين والفيروسات لكن
+
+238
+00:18:18,630 --> 00:18:23,610
+بالإضافة إلى هذه المعلومةإن ال replication of
+
+239
+00:18:23,610 --> 00:18:28,250
+viruses is so different from that of other
+
+240
+00:18:28,250 --> 00:18:33,310
+microorganisms، ليش؟ احنا capable من التكاتر عننا،
+
+241
+00:18:33,310 --> 00:18:37,490
+من الانقسام عننا، الخلية بتصير، بتنتهي، مصبوط؟
+
+242
+00:18:37,490 --> 00:18:42,930
+والبكتيريا كذلك الأمر، البكتيريا بالانقسام الثنائي
+
+243
+00:18:42,930 --> 00:18:47,310
+البسيط، احنا بالmyosis والmyotosis، صح ولا لأ؟لكن
+
+244
+00:18:47,310 --> 00:18:52,630
+الفيروسات بيدخل الفيروس داخل خلية بيطلع مئات
+
+245
+00:18:52,630 --> 00:18:58,070
+الفيروس يبقى طريقة التكاثر معاها unique فريدة
+
+246
+00:18:58,070 --> 00:19:02,710
+متميزة متفردة عن باقي المخلوقات إذا obligate
+
+247
+00:19:02,710 --> 00:19:08,070
+intracellular parasite رقم اتنين they reproduce in
+
+248
+00:19:08,070 --> 00:19:10,870
+a manner different from that dose of prokaryotes
+
+249
+00:19:10,870 --> 00:19:13,610
+and eukaryotes يعني مش زي الخلايا
+
+250
+00:19:16,370 --> 00:19:20,650
+طبعاً هدولا النقطتين مهمين جدا لكن النقطة اللي أهم
+
+251
+00:19:20,650 --> 00:19:26,970
+من ذلك المحتوى الوراثي المحتوى الوراثي ذكرنا قبل
+
+252
+00:19:26,970 --> 00:19:32,530
+قليل أنه الفيروسات تحتوي مادة وراثية يا إما DNA يا
+
+253
+00:19:32,530 --> 00:19:37,950
+إما RNA but never both بينما كل المخلوقات الأخرى
+
+254
+00:19:37,950 --> 00:19:43,470
+تحتوي على كل من ال DNA و ال RNA إذا هذا فرق أساسي
+
+255
+00:19:43,470 --> 00:19:49,540
+ومهم جدابعض الفيروسات تمتلك ما يسمى بال envelope
+
+256
+00:19:49,540 --> 00:19:53,040
+اللي احنا نقول عنها enveloped viruses من وين هذا
+
+257
+00:19:53,040 --> 00:19:57,440
+ال envelope جاي؟ تخيلوا معايا هاي الفيروس وهي ال
+
+258
+00:19:57,440 --> 00:20:02,740
+cell membrane بتاع الخلية ال host الفيروس هو طالع
+
+259
+00:20:02,740 --> 00:20:09,220
+بياخد جزء من ال membrane بيقطعه و بطلع فيه برا فال
+
+260
+00:20:09,220 --> 00:20:12,820
+membrane هذا الآن صار مين محيط بال virus لاحظوا
+
+261
+00:20:12,820 --> 00:20:19,330
+شغلة ان وجود هذا ال membraneإله مزايا وإله عيوب
+
+262
+00:20:19,330 --> 00:20:25,610
+إيش مزايا بتتوقعوا؟ مدام هو جزء من ال horse cell
+
+263
+00:20:25,610 --> 00:20:31,610
+لو بديعمل infection لخلية تانية مابيحتاجش إلى
+
+264
+00:20:31,610 --> 00:20:36,190
+receptors بس بيعمل fusion بيرتبط ال membrane مع ال
+
+265
+00:20:36,190 --> 00:20:41,630
+membrane و الفيروس يدخل جوا بكل سهولة صح؟ هذا رقم
+
+266
+00:20:41,630 --> 00:20:46,590
+واحد، هذا رقم اتنين جهاز المناعة بتعرفش عليه، ليش؟
+
+267
+00:20:47,110 --> 00:20:52,150
+ما هو جزء من مين؟ من الهواص، سرق، إذا في مستين،
+
+268
+00:20:52,150 --> 00:20:56,570
+إنه دخوله للخلايا بيصير سهل و بيهرب من مين؟ من
+
+269
+00:20:56,570 --> 00:21:00,690
+جهاز المناقة، طب إيش هيوبه؟ لو خرج إلى الخارج،
+
+270
+00:21:00,690 --> 00:21:07,230
+خارج الجسم، على الأسطح مثلا، وجف قليلا، بيخرب ال
+
+271
+00:21:07,230 --> 00:21:13,570
+virusلو استخدمنا أي مادة مذيبة للدهون زي الكحول
+
+272
+00:21:13,570 --> 00:21:18,530
+البسيط بيدمر ال cell membrane إذا دمر ال cell
+
+273
+00:21:18,530 --> 00:21:21,170
+membrane اللي هو ال envelope بيبطل الفيروس قادر
+
+274
+00:21:21,170 --> 00:21:26,430
+على مين؟ على الإرتباط ودخول الخلايا، إذا خدنا نقول
+
+275
+00:21:26,430 --> 00:21:30,170
+إنه إله مزايا داخل الجسم وإله عيوب خارج الجسم إنه
+
+276
+00:21:30,170 --> 00:21:35,530
+environmentally مش stableيعني غير قادر على ثبات
+
+277
+00:21:35,530 --> 00:21:42,570
+لفترات طويلة في البيئة أدللكم بمثال بسيط، بتعرفوا
+
+278
+00:21:42,570 --> 00:21:46,070
+الفيروس اللي بيعمل أمراض في ال intestine، في
+
+279
+00:21:46,070 --> 00:21:50,410
+القمعة يعني، مثلا زي الإسهادط، زي ال rotavirus، لو
+
+280
+00:21:50,410 --> 00:21:53,690
+تخيلنا هذا إله envelope، و أحنا أكلناه، when
+
+281
+00:21:53,690 --> 00:21:58,570
+هيمور؟ع المعدة المعدة فيها حامض الحامض مش بيعمل
+
+282
+00:21:58,570 --> 00:22:04,570
+بيذيب الدهون فمستحيل اللاجي فيروس بيعمل
+
+283
+00:22:04,570 --> 00:22:11,030
+gastroenteritis ويكون له envelope وصل الصورة ال
+
+284
+00:22:11,030 --> 00:22:15,390
+envelope بيعطيه instability ايش هال instability؟
+
+285
+00:22:15,390 --> 00:22:19,890
+عدم استقرار وعدم ثبت بينما الفيروسات اللي مالهاش
+
+286
+00:22:19,890 --> 00:22:25,840
+envelope غالبا بتكون ثابتة في البيتوكل الفيروسات
+
+287
+00:22:25,840 --> 00:22:30,140
+اللى بتعمل gastrointestinal tract infection مالهاش
+
+288
+00:22:30,140 --> 00:22:39,720
+envelope فى فيروس شهير صديق لكم فيروس رussia هذا
+
+289
+00:22:39,720 --> 00:22:46,400
+صغير جدا ولا يمتلك envelope وعدم امتلاكه envelope
+
+290
+00:22:46,400 --> 00:22:53,450
+لو عطصنا وعلى الطاولة هذهجافة ولا لأ؟ الأصل لو انه
+
+291
+00:22:53,450 --> 00:22:57,910
+.. انه .. لو إله انفله بيحصل فيه بيجف وبيتدمر
+
+292
+00:22:57,910 --> 00:23:01,910
+بينما لإنه مالوش فبيبقى لفترات طويلة بيجي حاضرة
+
+293
+00:23:01,910 --> 00:23:05,450
+واحد بيمسك الطاولة هادى وبعد شوية بيحك عينه أو
+
+294
+00:23:05,450 --> 00:23:10,630
+بيحك أنفه أو بيتناول طعام بي .. بيت .. بينتقل ال
+
+295
+00:23:10,630 --> 00:23:14,590
+microbe من ال surfaces إلى الإنسان لإنه
+
+296
+00:23:14,590 --> 00:23:19,750
+environmentally stable مالوش انفل تمام؟
+
+297
+00:23:22,610 --> 00:23:27,550
+بالنسبة للفروقات الأخرى ما بين ال virus و ال other
+
+298
+00:23:27,550 --> 00:23:32,390
+cells كل الخلايا ماعدل البكتيريا طبعا تحتوي على
+
+299
+00:23:32,390 --> 00:23:36,970
+نواة حقيقية الفيروس ماعودش نواة كل الخلايا ماعدل
+
+300
+00:23:36,970 --> 00:23:41,650
+البكتيريا عندها mitochondria بينما الفيروسات
+
+301
+00:23:41,650 --> 00:23:46,670
+ماعندهاش أي شيء ribosomes البكتيريا و ال other
+
+302
+00:23:46,670 --> 00:23:51,170
+cells عندهم ribosomes لكن الفيروسات ماعندهاش
+
+303
+00:23:52,430 --> 00:23:57,970
+البيروس لا يمتلك من مقومات الخلايا الحية إلا حاجة
+
+304
+00:23:57,970 --> 00:24:01,730
+واحدة قدرته على ال replication يا جماعة قدرته على
+
+305
+00:24:01,730 --> 00:24:08,090
+ال replication وهي محدودة وين في host يعني مش برا
+
+306
+00:24:08,090 --> 00:24:10,950
+زي البكتيريا البكتيريا تقدر تعيش معيشة حرة هذا
+
+307
+00:24:10,950 --> 00:24:17,630
+بعيش معيشة حرة قلبهاالجدول البسيط بيحاول انه يفرق
+
+308
+00:24:17,630 --> 00:24:21,510
+ما بين طبعا تلخيص لما ذكرناه لكن لبس ان نمر عليهم
+
+309
+00:24:21,510 --> 00:24:27,730
+مرور بشكل سريع المادة الوراثية ال viruses يكون يا
+
+310
+00:24:27,730 --> 00:24:32,410
+اما DNA يا اما RNA بينما الخلايا كل من ال DNA و ال
+
+311
+00:24:32,410 --> 00:24:36,010
+RNA موجودين بالنسبة لل proteins في الفيروسات
+
+312
+00:24:36,010 --> 00:24:42,230
+موجودة لكن قليلة بينما يعني عماد تكوين الخلايا
+
+313
+00:24:42,230 --> 00:24:46,120
+الأخرىغالبا بيكون من مين؟ من ال protein فلازم تكون
+
+314
+00:24:46,120 --> 00:24:51,280
+كثيرة ايضا عندنا ال lipoprotein membrane ال
+
+315
+00:24:51,280 --> 00:24:54,740
+lipoprotein membrane في الخلايا العادية بيكون
+
+316
+00:24:54,740 --> 00:24:57,540
+موجود بكثرة سواء كان في النواء او في ال cell
+
+317
+00:24:57,540 --> 00:25:01,860
+membrane بينما في ال viruses لم نجده الا في ال
+
+318
+00:25:01,860 --> 00:25:06,700
+enveloped viruses ومأخوض من مين؟ من ال host cell
+
+319
+00:25:06,700 --> 00:25:09,600
+يعني مش هو اللي بيصنعه مأخوض ايضا من ال host cell
+
+320
+00:25:10,260 --> 00:25:13,820
+الريبوزومس بيقولنا غير موجودة في الفيروسات بس في
+
+321
+00:25:13,820 --> 00:25:19,380
+إشارة خدوا بالك جنب كلمة absent و تحت الجدول في
+
+322
+00:25:19,380 --> 00:25:25,760
+تعليق عليها بيقولكوا إستثناء واحد لفيروس اسمه
+
+323
+00:25:25,760 --> 00:25:32,740
+Arena virus و Arena من حلبة حلبة بجد تكون المفروضة
+
+324
+00:25:32,740 --> 00:25:36,870
+بالرملوسموا الفيروس هذا لما شافوا تحت ال
+
+325
+00:25:36,870 --> 00:25:40,710
+microscope لجوا انه فيه granules granules يعني
+
+326
+00:25:40,710 --> 00:25:44,610
+حبابية فذكرتهم باسم arena اللي هي الحلبة اللي فيها
+
+327
+00:25:44,610 --> 00:25:50,190
+الرمل تمام فسموه arena virus لما كشفوا عن ال .. ال
+
+328
+00:25:50,190 --> 00:25:54,170
+.. ال .. الحبابات هذه لجوها عبارة عن ribosomes
+
+329
+00:25:54,170 --> 00:25:57,330
+طبعا اللي على بعض يقولون انها non-functional ايش
+
+330
+00:25:57,330 --> 00:26:05,730
+يعني non-functional؟ يعني ملاك .. ملاك وظيفة؟يعني
+
+331
+00:26:05,730 --> 00:26:09,750
+غير فعالة مافيش فيها لكن احنا انا دايما بفضل مصطلح
+
+332
+00:26:09,750 --> 00:26:13,950
+ان احنا مش عارفين ايش فضل بيكون مافيش اشي بدون ..
+
+333
+00:26:13,950 --> 00:26:18,350
+بدون .. بدون .. بدون اشي لكن هذا غالبا بيكون احنا
+
+334
+00:26:18,350 --> 00:26:22,270
+لسه ماعرفناش الوظيفة تبعتها لكن عموما الفيروسات
+
+335
+00:26:22,270 --> 00:26:26,990
+كلها معادة هذا الفيروس لا تحتوي على ribosomes
+
+336
+00:26:26,990 --> 00:26:31,150
+بينما المخلوقات الأخرى كلها فيها ribosomes
+
+337
+00:26:31,770 --> 00:26:35,530
+الانزيمات هل تحتاج الفيروس ان يكون معاه انزيمات و
+
+338
+00:26:35,530 --> 00:26:41,510
+لا يحتاجه؟ هل يحتاج الفيروس ان يكون لديه جايب معه
+
+339
+00:26:41,510 --> 00:26:48,230
+انزيمات و لا بيحتاجه؟ طيب إذا افترضنا ان انزيمات
+
+340
+00:26:48,230 --> 00:26:53,260
+الخلية مابتقدريش الغرض انا بيالقعها هاي تمام؟و
+
+341
+00:26:53,260 --> 00:26:57,840
+لازمني انا طبعا في القاعات الأخرى ممكن يكون او
+
+342
+00:26:57,840 --> 00:27:03,680
+لأخرين بيحطولهم flash انا نفسي اكسبني الأخ المصور
+
+343
+00:27:03,680 --> 00:27:06,380
+هناك ومش حاطلي flash انا كل ما اجي هناك لازم اخد
+
+344
+00:27:06,380 --> 00:27:10,680
+معايا مين ال flash تبعي ففي بعض الانزيمات لا تجد
+
+345
+00:27:10,680 --> 00:27:15,700
+بغيات افهم بعض الفيروسات لا تجد بغياتها في مكونات
+
+346
+00:27:15,700 --> 00:27:20,210
+الخلية فبتحضر مكونات معاها جاهزةففي بعض الفيروس
+
+347
+00:27:20,210 --> 00:27:27,010
+تحتاج إلى بعض الانزمات لكن قليل جدا قليل جدا بينما
+
+348
+00:27:27,010 --> 00:27:31,870
+الخلايا الخلايا الانزمات يعني بدون انزمات مافيش
+
+349
+00:27:31,870 --> 00:27:35,990
+انا قلتلكم ان خلية بدون protein خلية محكم عليها
+
+350
+00:27:35,990 --> 00:27:43,270
+بالموت والانزمات كلها protein عملية الانقسام بال
+
+351
+00:27:43,270 --> 00:27:45,930
+binary vision او ال mitosis طبعا غير موجودة في
+
+352
+00:27:45,930 --> 00:27:48,830
+الفيروسات بينما موجودة في من؟ في الخلايا
+
+353
+00:27:52,160 --> 00:27:58,800
+ناخد فكرة و تصور عن حجوم البيروسات اذكركم
+
+354
+00:27:58,800 --> 00:28:01,780
+بالبكتيريا لما عملتوا gram stain و مثلين blue
+
+355
+00:28:01,780 --> 00:28:06,620
+stain و طلعتوا تحت الميكروسكوب و شوفتوا البكتيريا
+
+356
+00:28:06,620 --> 00:28:11,380
+كانت عبارة عن شحتة او نقطة gram positive او gram
+
+357
+00:28:11,380 --> 00:28:17,860
+negative وهذه يا بنات الحجم تبعها طول ال E.coli
+
+358
+00:28:17,860 --> 00:28:21,780
+عايز المثال 3 مايكرون عرضها ثمكة يعني
+
+359
+00:28:26,320 --> 00:28:34,620
+الميكرون ألف نانو متر الميكرون ألف نانو متر الف
+
+360
+00:28:34,620 --> 00:28:37,580
+نانو متر الف نانو متر الف نانو متر الف نانو متر
+
+361
+00:28:37,580 --> 00:28:37,600
+الف نانو متر الف نانو متر الف نانو متر الف نانو
+
+362
+00:28:37,600 --> 00:28:37,700
+متر الف نانو متر الف نانو متر الف نانو متر الف
+
+363
+00:28:37,700 --> 00:28:37,960
+نانو متر الف نانو متر الف نانو متر الف نانو متر
+
+364
+00:28:37,960 --> 00:28:40,800
+الف نانو متر الف نانو متر الف نانو متر الف نانو
+
+365
+00:28:40,800 --> 00:28:48,640
+متر الف نانو متر الف نانو متر الف نانو متر الف
+
+366
+00:28:48,640 --> 00:28:56,430
+نانويعني أشهر بالحجوم لازم نشوفها لازم نشوفها بس
+
+367
+00:28:56,430 --> 00:29:00,270
+خلّيني قبل ما نشوفها نعمل analogy analogy يعني
+
+368
+00:29:00,270 --> 00:29:05,810
+مقاربة بيقولنا أن أكبر بروتين تقريبا حجمه عشرين
+
+369
+00:29:05,810 --> 00:29:11,510
+نانومتر إذا في فيروسات تشابه في الحجم one single
+
+370
+00:29:11,510 --> 00:29:17,790
+proteinوأصغر المخلوقات الحية اللى بنعرفها احنا ال
+
+371
+00:29:17,790 --> 00:29:21,550
+microplasma فاكرينها؟ ال microplasma كبكتيريا هي
+
+372
+00:29:21,550 --> 00:29:27,410
+أصغر بكتيريا تقريبا 400 نانو نيتر أو 300 نانو نيتر
+
+373
+00:29:27,410 --> 00:29:33,520
+فبتقول انه أصغرحجم في الفيروسات يساوي اكبر حجم في
+
+374
+00:29:33,520 --> 00:29:38,200
+البروتينات و اكبر حادة في الفيروسات قد تشابه او قد
+
+375
+00:29:38,200 --> 00:29:45,020
+توازي اصغر بكتيداليال مايكو إبلاسما كيف نطلق
+
+376
+00:29:45,020 --> 00:29:51,860
+الأسماء على الفيروسات؟فيه أن مصطلح اسمه colloquial
+
+377
+00:29:51,860 --> 00:29:57,540
+terms وcolloquial terms يعني مصطلحات هبهزن عشوائية
+
+378
+00:29:57,540 --> 00:30:01,980
+يعني مما نراه نحن بالعامية مالاش أساس علم مثلا
+
+379
+00:30:01,980 --> 00:30:08,140
+بنقول عنها كوريات spheres أو rods عصويات أو مثل
+
+380
+00:30:08,140 --> 00:30:12,520
+الرصاصة على سبيل المثال أو مثل ال block تبع الطوب
+
+381
+00:30:12,520 --> 00:30:16,710
+تمام اللي بنبني فيه هذا bricksلكن واقع الأمر لو
+
+382
+00:30:16,710 --> 00:30:20,790
+دخلنا في التفاصيل الشكلية لهذه الفيروسات سنجد يا
+
+383
+00:30:20,790 --> 00:30:26,610
+بنات تركيب معقدة جدا ونظام .. خلّيني أسميه
+
+384
+00:30:26,610 --> 00:30:29,690
+geometrical symmetry إيش هي geometrical symmetry؟
+
+385
+00:30:29,690 --> 00:30:37,970
+تماثل هندسي دقيق جدا لهذه الفيروسة طبعا اللي بيعطي
+
+386
+00:30:37,970 --> 00:30:43,830
+التماثل الدقيق تركيب اسمه capsid ال capsid عبارة
+
+387
+00:30:43,830 --> 00:30:52,730
+عن proteinيحيط بالمادة الوراثية إذا الفيروس الكامل
+
+388
+00:30:52,730 --> 00:30:58,430
+قد يتكون فقط من قطعتين أو من جزئين مادة وراثية
+
+389
+00:30:58,430 --> 00:31:05,410
+نوكليو و من كابسيل و بيسموها نوكليو كابسيل الآن
+
+390
+00:31:05,410 --> 00:31:14,100
+هذا ال protein coat مش مكون منتركيب مختلفة مكون من
+
+391
+00:31:14,100 --> 00:31:21,920
+تركيب واحد متعدد اش يعني ايه؟ monomer اش هات
+
+392
+00:31:21,920 --> 00:31:27,340
+monomer؟ mono .. monomer يعني بروتين واحد اعطيكم
+
+393
+00:31:27,340 --> 00:31:30,560
+مثال بس عشان تخيلوا تعرف ال glul؟ اكيد ياخدوكوا
+
+394
+00:31:30,560 --> 00:31:36,200
+الصغار بلعبوا معاهم لو أخدنا حفنة من ال glul هاي و
+
+395
+00:31:36,200 --> 00:31:41,420
+رمناها على جهةو فجأة وجدناها قاعدة تتصفق فوق بعضها
+
+396
+00:31:41,420 --> 00:31:44,840
+و بتشكلي تركيبها .. انتوا إيش بتقولوا انتوا هذا
+
+397
+00:31:44,840 --> 00:31:50,700
+خيال علمي اه؟ مادة قادرة على انها تجمع ذاتها
+
+398
+00:31:50,700 --> 00:31:57,920
+بذاتها و بمصطلح بنسميه احنا self assembly assembly
+
+399
+00:31:57,920 --> 00:32:04,440
+تجميع self assembly الان هذا ما يحدث حقا في
+
+400
+00:32:04,440 --> 00:32:09,570
+الفيروساتالفيروسات لو احنا أخدنا المادة هذه
+
+401
+00:32:09,570 --> 00:32:12,890
+وحطناها في test tube لحالها بدون فيروس ولا بدون
+
+402
+00:32:12,890 --> 00:32:17,450
+مادة دولارتية هتجمع لوحدها بتشكل symmetrical
+
+403
+00:32:17,450 --> 00:32:24,470
+compound وهذا شيء رائع هنتكلم عنه كمان شوية أو في
+
+404
+00:32:24,470 --> 00:32:29,310
+المحاضرة اللي جاي ان شاء الله بنه الإحساس بالحجوم
+
+405
+00:32:29,310 --> 00:32:34,960
+مهم جدا الجزء الأحمر هذا اللي شايفينه احناهذا قطعة
+
+406
+00:32:34,960 --> 00:32:40,740
+من محيط ال red blood cell دراسته ال red blood cell
+
+407
+00:32:40,740 --> 00:32:45,140
+جداش حجمها؟ سبعة و نص مايكرون سبعة و نص مايكرون
+
+408
+00:32:45,140 --> 00:32:51,300
+القطر تبعها هذه السفينة الفضاء العجيبة هذي شريشا
+
+409
+00:32:51,300 --> 00:33:00,740
+كولاي جداش حجمها؟تلتلاف طول ب ألف قطر، الألف اللي
+
+410
+00:33:00,740 --> 00:33:03,280
+قلنالك هو واحد ايش؟ مايكرون، اللي هو ال 1000
+
+411
+00:33:03,280 --> 00:33:08,040
+نانومتر واحد مايكرون، تطلعولي على الفيروسات، أضخم
+
+412
+00:33:08,040 --> 00:33:12,200
+فيروس على الإطلاق اسمه Ebola virus، في الأخبار
+
+413
+00:33:12,200 --> 00:33:17,300
+أكيد تسمعويلي منهافيروس Ebola من أخطر الفيروسات
+
+414
+00:33:17,300 --> 00:33:23,140
+على كوكب الأرض وهو مولود في أفريقيا والإنسان الذي
+
+415
+00:33:23,140 --> 00:33:27,060
+يوصي بيه يمكن نسبة الوفيات تصل إلى تسعين بالمائة
+
+416
+00:33:27,060 --> 00:33:32,720
+تسعين بالمائة فالنسبة القتل عنده عالي جدا ومرض
+
+417
+00:33:32,720 --> 00:33:37,760
+خطير جداوأكبر ال virus أو أكبر الفيروسات ومع ذلك
+
+418
+00:33:37,760 --> 00:33:41,440
+لو أخدناها لو لو لنا قدرة أنه نعمل drug and drop
+
+419
+00:33:41,440 --> 00:33:44,840
+كان سحبناها وحطناها في الإشريش الكولاي في في في
+
+420
+00:33:44,840 --> 00:33:48,040
+زاوية من زوايا الإشريش الكولاي ده لا لا لا إشريش
+
+421
+00:33:48,040 --> 00:33:53,860
+ان هو كبير اه نعم مقارنة مع مين؟ مع الفيروسات لكن
+
+422
+00:33:53,860 --> 00:33:57,560
+بالنسبة للإشريش الكولاي صغير صلولي على فيروس الرشح
+
+423
+00:33:57,560 --> 00:34:02,720
+اللي حطي على الماوس أنا هنا شوفينه؟ هذا تلاتين
+
+424
+00:34:02,720 --> 00:34:06,240
+نانومترهذا اللي .. اللي .. اللي كل سنة بيزورنا
+
+425
+00:34:06,240 --> 00:34:10,120
+مرتين تلاتة كل واحد فينا تمام؟ ومش قادرين نتخلص
+
+426
+00:34:10,120 --> 00:34:14,840
+منه تلاتين nanometer فقط فيه فيروسات كبيرة زي ال
+
+427
+00:34:14,840 --> 00:34:18,560
+.. ال variola و ال smallpox اللي هو الجدري و ال ..
+
+428
+00:34:18,560 --> 00:34:21,520
+ال .. الجدري ال .. cowpox اللي بيسموه الجدري
+
+429
+00:34:21,520 --> 00:34:24,900
+الأبقار برضه فيروس من الفيروسات الكبيرة لكن كلهم
+
+430
+00:34:24,900 --> 00:34:29,260
+لو جمعناهم يا جماعة و حاطناهم في ال E.coli .. ال E
+
+431
+00:34:29,260 --> 00:34:34,070
+.coli التساهمة دلالة على أنه الفيروسات صغيرةهذه
+
+432
+00:34:34,070 --> 00:34:39,530
+اللوحة أرجو أنها تكون أعطتكم إحساس بالحجوم بتاعة
+
+433
+00:34:39,530 --> 00:34:42,770
+ال .. كل من Red blood cell اللي أنتوا بتشوفوها في
+
+434
+00:34:42,770 --> 00:34:47,350
+ال blood film كرة صغيرة صح؟ و البكتيريا بتشوفوها
+
+435
+00:34:47,350 --> 00:34:53,290
+شحتة صغيرة فيستحيل نقدر نشوف الفيروسات under the
+
+436
+00:34:53,290 --> 00:34:57,230
+ordinary microscope بدنا electron microscope عشان
+
+437
+00:34:57,230 --> 00:34:59,210
+نقدر نشوف هذه المخلوقة
+
+438
+00:35:01,480 --> 00:35:05,760
+أنا ذكرت في التركيب قولت إنه فيه هنا ال virus
+
+439
+00:35:05,760 --> 00:35:11,400
+بتكون من شغلتين بتكون من capsid و بتكون من مادة
+
+440
+00:35:11,400 --> 00:35:15,640
+وراتية وسميناهم nuclear capsid أنا مش قولت monomer
+
+441
+00:35:15,640 --> 00:35:20,360
+ال monomer عشان انه بيكون capsid سموه capsomer إذن
+
+442
+00:35:20,360 --> 00:35:25,260
+هو capsomer بيكون capsid فهمتوش ال capsomer هو
+
+443
+00:35:25,260 --> 00:35:30,100
+monomer واحدة بناء ل ال capsidكل هذا اللي سميناه
+
+444
+00:35:30,100 --> 00:35:34,060
+مع بعض وقلنا نوكليو كابسيت الـ nuclear capsule
+
+445
+00:35:34,060 --> 00:35:40,700
+طبعا في تراكيب أخرى إضافية هنترقلها لما اتكلم عن
+
+446
+00:35:40,700 --> 00:35:46,280
+اللي هو التراكيب الأخرى في الفيروس هذا كمان بعطينا
+
+447
+00:35:46,280 --> 00:35:51,120
+إيحاء بأشكال الفيروسات المختلفة طلعوا ليه على هذا
+
+448
+00:35:53,540 --> 00:35:58,540
+عشان عامة زي في فاكهة في جنوب الشرق أسيا اسمها
+
+449
+00:35:58,540 --> 00:36:02,120
+jackfruit تدوروا عليها في الفيلم هتلاقوها نفس
+
+450
+00:36:02,120 --> 00:36:08,020
+الشكل هذا jackfruit تمام؟ هذا شكل منتظم تماما و
+
+451
+00:36:08,020 --> 00:36:13,560
+بيسموه أشروني .. أشروني يعني عشرين أشروني الوجوه
+
+452
+00:36:13,560 --> 00:36:20,050
+او icosa-hedral و icosa حيمرمع هتجلجوشecosahedral
+
+453
+00:36:20,050 --> 00:36:24,830
+symmetry يعني لو اللي نطلعنا هو شكله زي الكرة لكن
+
+454
+00:36:24,830 --> 00:36:29,510
+الكرة مكونة من عشرين مثلث عشرين مثلث سموها
+
+455
+00:36:29,510 --> 00:36:36,790
+ecosahedral هذا حلقي spiral و عامل زي العكاز اللي
+
+456
+00:36:36,790 --> 00:36:38,390
+هو ال إيبول اللي شفناها قبل شوية اللي عامل زي
+
+457
+00:36:38,390 --> 00:36:46,570
+الدودة إذا فينا شكلين رئيسيين helical إيش يعني
+
+458
+00:36:46,570 --> 00:36:51,540
+helical؟الحلزون اللولوي و Ecosahedral اللي يقول
+
+459
+00:36:51,540 --> 00:36:59,600
+عنه أشروني الوجوه قد نجد بعض الفيروسات تختلف تمتلك
+
+460
+00:36:59,600 --> 00:37:05,160
+شغلتين مع بعض مثلا وين
+
+461
+00:37:05,160 --> 00:37:08,900
+ال bacterium phage كيفين ال bacterium phage اللي
+
+462
+00:37:08,900 --> 00:37:15,850
+هنا الرأس تبعه Ecosahedralلكن ال cooler في الوزن
+
+463
+00:37:15,850 --> 00:37:21,410
+هذا الفيروس helical وهذا بيسموه complex إذا ماكانش
+
+464
+00:37:21,410 --> 00:37:26,350
+icosahedral أو helical مش بيسميه complex complex
+
+465
+00:37:26,350 --> 00:37:29,890
+يعني معقد غالبا بيكون ماخد شكل غير عن الشكليين
+
+466
+00:37:29,890 --> 00:37:34,630
+التانية اللي احنا شوفناها ألخص إيش استفادنا من
+
+467
+00:37:34,630 --> 00:37:40,010
+المحاضرة هذه عرفنا إيش فيروسات كينات حية و لا مش
+
+468
+00:37:40,010 --> 00:37:46,400
+كينات حيةلأ احنا بدنا نفتي في فتوة لو لا مارسنا
+
+469
+00:37:46,400 --> 00:37:51,100
+فتوة مافتوش فيها لحتى لو بمختلفين لاتنتلك من صفات
+
+470
+00:37:51,100 --> 00:37:55,020
+الحياة إلا قدرتها على التكاثر ومشروطة
+
+471
+00:37:55,020 --> 00:38:00,280
+intracellular ولا تنتلك DNA وRNA واحد من التانية
+
+472
+00:38:00,280 --> 00:38:05,720
+يا إما DNA يا إما RNA المكونات تبعتها بسيطة تكاثر
+
+473
+00:38:05,720 --> 00:38:11,990
+تبعها غريب يختلف عن تكاثر المخلوقات الأخرىالحجوة
+
+474
+00:38:11,990 --> 00:38:18,070
+تبعها من 20 إلى 300 نانو متر ورأينا كيف المقارنة
+
+475
+00:38:18,070 --> 00:38:21,250
+بينها وبين الاشتشاكولاي وما بين الورد بلود
+
+476
+00:38:21,250 --> 00:38:26,030
+سيلفشوفنا أشكال مختلفة لكن صنفنا الأشكال لتلاتة
+
+477
+00:38:26,030 --> 00:38:30,270
+الـ Causohedral, Helical و Complex هاي التلات
+
+478
+00:38:30,270 --> 00:38:37,100
+أشياء اللي احنا عرفناها لحد الآن طيبناخد جزء متعلق
+
+479
+00:38:37,100 --> 00:38:41,740
+بالمادة الوراثية لأن هذا أساسي في تصنيف الفيروسات
+
+480
+00:38:41,740 --> 00:38:44,280
+اللي معاها المادة الوراثية
+
+481
+00:38:47,000 --> 00:38:52,720
+مكوّنة للبيروسات إما DNA وإما RNA، الآن هذا أمر
+
+482
+00:38:52,720 --> 00:38:55,520
+سهل أن نقوله، صح هذا لأ؟ كتير سهل، إما DNA ولا
+
+483
+00:38:55,520 --> 00:38:59,620
+RNA، الآن النقطة التانية إنه Single-Stranded أو
+
+484
+00:38:59,620 --> 00:39:04,080
+Double-Stranded، أيضًا لا يورد في أي مخلوقات أخرى
+
+485
+00:39:04,080 --> 00:39:08,100
+أن يكون المادة اللي هو الأن Single-Strandedبس في
+
+486
+00:39:08,100 --> 00:39:11,740
+الفيروسات في single-stranded DNA و في single
+
+487
+00:39:11,740 --> 00:39:17,200
+-stranded RNA تخيلوا فإذا التصنيف بطل DNA و RNA بس
+
+488
+00:39:17,200 --> 00:39:22,800
+DNA single-stranded double-stranded RNA double
+
+489
+00:39:22,800 --> 00:39:31,540
+-stranded و single-stranded في كمان شغل تاني الشغل
+
+490
+00:39:31,540 --> 00:39:37,260
+التاني ان ال RNA ال RNA قد يكون whole RNAأو
+
+491
+00:39:37,260 --> 00:39:42,240
+segmented RNA، إيش يعني segmented؟ قطة ال
+
+492
+00:39:42,240 --> 00:39:45,620
+influenza virus على سبيل المثال فيها eight
+
+493
+00:39:45,620 --> 00:39:49,580
+segments المادة الوراثية تبعتها eight segments،
+
+494
+00:39:49,580 --> 00:39:53,500
+ثمن قطع عشان هي كمان لما بيجي فيروس و فيروس و
+
+495
+00:39:53,500 --> 00:39:56,880
+بيدخلوا داخل خلية، تمام؟ من نوعين مختلفين
+
+496
+00:39:56,880 --> 00:40:01,140
+الفيروسات، من صنفين مختلفينالمادة الوراثية قد
+
+497
+00:40:01,140 --> 00:40:05,940
+تختلط وتروح قطعة من هذا ال virus لمن؟ ل virus آخر،
+
+498
+00:40:05,940 --> 00:40:10,580
+هذا ال virus الآخر بيمتلك الآن صفات جديدة، هذه
+
+499
+00:40:10,580 --> 00:40:17,150
+الصفات الجديدةمنها أنتجينات فلابدوا لأن على
+
+500
+00:40:17,150 --> 00:40:24,070
+أجسامنا تمام هذه الفيروسات كإنها فيروسات جديدة
+
+501
+00:40:24,070 --> 00:40:28,990
+جسمنا ما بتعرف عليها إنها أصابع تساجقك وبالتالي
+
+502
+00:40:28,990 --> 00:40:34,210
+تحدث مرض لدينا هذا واحد، اتنين قد تمتلك بعض عوامل
+
+503
+00:40:34,210 --> 00:40:39,830
+الشراسة الجديدة تسمعوا بإنفلوانزا الطيور؟القلوانزة
+
+504
+00:40:39,830 --> 00:40:46,090
+الطيورة بنات نسبة القتل فيها وصلت ل 65% انتشارها
+
+505
+00:40:46,090 --> 00:40:50,130
+ضعيف، يعني كل اللي أصابتهم لحد الآن حول العالم من
+
+506
+00:40:50,130 --> 00:40:54,650
+سبعة سنوات أو تمان سنوات، لها دلوقت تلت تلف، لكن
+
+507
+00:40:54,650 --> 00:40:59,470
+التلت تلف شخص اللي أصيبه أكتر من نصفهم ماتوايبقى
+
+508
+00:40:59,470 --> 00:41:04,170
+عامة شراسة قوية جدا في هذا الفيروس غير موجود فيه
+
+509
+00:41:04,170 --> 00:41:07,690
+نحن بنوصب بالإنفلوانزا العادية باستمرار و دلوقت ..
+
+510
+00:41:07,690 --> 00:41:08,890
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+511
+00:41:08,890 --> 00:41:11,770
+.. او .. او .. او .. او .. او .. او .. او .. او ..
+
+512
+00:41:11,770 --> 00:41:12,210
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+513
+00:41:12,210 --> 00:41:16,410
+او .. او .. او ..
+
+514
+00:41:16,410 --> 00:41:20,650
+او ..
+
+515
+00:41:30,110 --> 00:41:34,830
+غالبا الذين يموتون من ال influence هم من كبار السن
+
+516
+00:41:34,830 --> 00:41:39,470
+كلمة كبار السن غالبا مثلا في دولة زي اليابان
+
+517
+00:41:39,470 --> 00:41:48,070
+المتوسط ال life expectancy صار فوق السبعين صار فوق
+
+518
+00:41:48,070 --> 00:41:55,410
+السبعين فبنلاقي نسبة كبيرة من الناسفي هذه الفئة،
+
+519
+00:41:55,410 --> 00:42:00,590
+الفئة مين؟ ال very old age وبالتالي هم هدول الناس
+
+520
+00:42:00,590 --> 00:42:03,990
+اللي دي أكتر ناس ممكن يصابوا بيه أو يموتوا من
+
+521
+00:42:03,990 --> 00:42:09,270
+أمراض مثل اللي هو ال influenza، لكن بشكل عامالمادة
+
+522
+00:42:09,270 --> 00:42:15,410
+الوراثية المجزقة تسهل عملية تبادل القطع وبالتالي
+
+523
+00:42:15,410 --> 00:42:19,970
+في أنحاء اسمها Antigenic Variation Antigenic
+
+524
+00:42:19,970 --> 00:42:23,670
+Variation يعني أيه؟ التغير الجيني من سلالة إلى
+
+525
+00:42:23,670 --> 00:42:30,150
+سلالة أخرى وهذا يعطي أفضلية للفيروس في أنه يحدث
+
+526
+00:42:30,150 --> 00:42:33,930
+دائمًا اللي هو العمل دي كمان نقطة كتير مهمة
+
+527
+00:42:34,570 --> 00:42:40,630
+الفيروسات تنتلق نسخة واحدة من المادة الوراثية داخل
+
+528
+00:42:40,630 --> 00:42:45,630
+النوكليوكابسي نسخة واحدة زي الخلال الجنسية عند
+
+529
+00:42:45,630 --> 00:42:50,930
+الإنسان أكم .. أكم كرموزومي احنا؟ 46 مظبوط، لكن
+
+530
+00:42:50,930 --> 00:42:59,470
+البوايضة؟ 23، ال sperm؟ 23 فالفيروسات تنتلق نسخة
+
+531
+00:42:59,470 --> 00:43:01,870
+واحدة، ايش بنسمي النسخة الواحدة احنا في الوراثة؟
+
+532
+00:43:03,510 --> 00:43:07,450
+لما يكونوا تنتهيوا يسميها deployed يا هل تلاقي فيه
+
+533
+00:43:07,450 --> 00:43:11,350
+فيروسات عندها deployed نعم فيه فيروسات عندها
+
+534
+00:43:11,350 --> 00:43:16,890
+deployed لكن استثناء يعني فيروس واحدة اللي بنعرفه
+
+535
+00:43:16,890 --> 00:43:22,670
+اللي هو ال HIV الفيروس ال AIDS فيه نسختين من
+
+536
+00:43:22,670 --> 00:43:24,530
+المادة الوراقية
+
+537
+00:43:28,940 --> 00:43:31,240
+طيب، اللخص لأن المادة الوراثية بالنسبة لي كتير
+
+538
+00:43:31,240 --> 00:43:38,240
+مهمة في ال .. في ال .. في الفيروسات عندي الفيروس
+
+539
+00:43:38,240 --> 00:43:45,560
+يختلف عن الخلايا بإنه يحتوي يا إما DNA يا إما RNA
+
+540
+00:43:45,560 --> 00:43:49,780
+يعني ال DNA و ال RNA بطل DNA أو RNA عادي يا إما
+
+541
+00:43:49,780 --> 00:43:53,340
+double-stranded يا إما single-stranded و single
+
+542
+00:43:53,340 --> 00:43:58,920
+-stranded يا إما whole يا إما segmentedو مرة أخرى
+
+543
+00:43:58,920 --> 00:44:03,540
+الجينوم ككل ممكن يكون haploid و ممكن يكون diploid
+
+544
+00:44:03,540 --> 00:44:07,100
+و المرة الجاية ان شاء الله بنكمل في نفس السياق
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6789e55b675cf12a05a66cddbe2e4a1632ad1026
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/OJkYQZfU2vA_raw.srt
@@ -0,0 +1,2212 @@
+1
+00:00:20,870 --> 00:00:22,790
+بسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:22,790 --> 00:00:26,370
+الصلاة والسلام على سيدنا محمد وعلى آله وصحبه ومن
+
+3
+00:00:26,370 --> 00:00:30,570
+ساعده ربيع الأعمال الدين كل عام وانتم بخير بمناسبة
+
+4
+00:00:30,570 --> 00:00:33,690
+بدء الفصل الدراسي الجديد وان شاء الله يكون عام خير
+
+5
+00:00:33,690 --> 00:00:38,950
+وجد واجتهاد ونجاح بإذن الله مصاق اللي هندرسه مع
+
+6
+00:00:38,950 --> 00:00:42,280
+بعض ان شاء الله اليوم اللي هو ال biologyو الحقيقة
+
+7
+00:00:42,280 --> 00:00:46,940
+انكم محظوظين انكم درستم essential و medical
+
+8
+00:00:46,940 --> 00:00:50,520
+microbiology سابقا لهذا ال course لأنه كتير من
+
+9
+00:00:50,520 --> 00:00:54,400
+المعلومات المذكورة في هذا المصاد ستجدوا انكم
+
+10
+00:00:54,400 --> 00:01:00,610
+بتعرفوها مسبقا ان شاء اللهقبل ما ابدأ بعرض مفارضات
+
+11
+00:01:00,610 --> 00:01:07,230
+المساق بنحاول نشوف اللي هو course outline او ال
+
+12
+00:01:07,230 --> 00:01:12,030
+course syllabus طبعا بتعرفوني عبدالروف المنعمة
+
+13
+00:01:12,030 --> 00:01:19,860
+مدرسكم السابق المساق اسمه virologyو العدد الساعات
+
+14
+00:01:19,860 --> 00:01:24,220
+المعتبدة هو ثلاث ساعات فقط لغير ال course number
+
+15
+00:01:24,220 --> 00:01:30,980
+ميدي تلاتة تلاتة خمسة أربع الساعات اللي بنلتقي
+
+16
+00:01:30,980 --> 00:01:34,160
+فيها ان شاء الله هي من التاسعة إلى العشرة سبت
+
+17
+00:01:34,160 --> 00:01:37,860
+اثنين اربعاء في هذه القاعة اللي هي الان M601
+
+18
+00:01:39,840 --> 00:01:43,760
+ال website الخاص بيه انا برضه بتعرفوه موجود على
+
+19
+00:01:43,760 --> 00:01:46,620
+المحاضرة ان شاء الله ال email تبعي انا و بفضل
+
+20
+00:01:46,620 --> 00:01:50,220
+وسيلة التواصل اما على ال facebook او على ال email
+
+21
+00:01:50,220 --> 00:01:54,540
+يعني اكثر من هاتف او زيارة حتى المكتب مع انه
+
+22
+00:01:54,540 --> 00:01:58,780
+هتخصكوا ان شاء الله ساعات مكتبية بالنسبالي اللي هي
+
+23
+00:01:58,780 --> 00:02:03,500
+الغالبا بعد المحاضرة من ال 11 من العشرة ال 11 سبت
+
+24
+00:02:03,500 --> 00:02:06,080
+اتنين اربعة ساعات مكتبية بتكونوا فاضين فيها ولا
+
+25
+00:02:06,080 --> 00:02:13,470
+مشغولين؟ مشغولين؟من ال 11 ل 12 برضه فرق خلاص ممكن
+
+26
+00:02:13,470 --> 00:02:18,790
+نمدها من العشرة ل 12 ان شاء الله العشرة ل 12 طبعا
+
+27
+00:02:18,790 --> 00:02:23,910
+المكتب يقنع الجديد في الطابق التالت في مبنى العلوم
+
+28
+00:02:23,910 --> 00:02:28,210
+الطبية المخبرية في قسم التحيط الطبية يعني بقرب من
+
+29
+00:02:28,210 --> 00:02:32,730
+مكاتب الأساتذة في القسم ان شاء اللهبالنسبة لل
+
+30
+00:02:32,730 --> 00:02:37,570
+facebook group مننا group لكم اسمها Virology 201،
+
+31
+00:02:37,570 --> 00:02:42,250
+201 على رقم الشعب اللي أنتوا تسجلين فيها، لو فت ..
+
+32
+00:02:42,250 --> 00:02:45,650
+لو فتحتوا عليها اليوم ان شاء الله و عملتوا انضمام،
+
+33
+00:02:45,650 --> 00:02:49,050
+طلب انضمام، هتلاقوا المحاضرة اللي معانا الآن
+
+34
+00:02:49,050 --> 00:02:51,570
+موجودة و ال course outline أو ال course syllabus
+
+35
+00:02:51,570 --> 00:02:56,760
+أيضا هتلاقوه ان شاء الله موجودبالنسبة ل الكتاب هو
+
+36
+00:02:56,760 --> 00:03:00,220
+كتاب عالم مشهور اسمه a review of medical
+
+37
+00:03:00,220 --> 00:03:05,160
+microbiology and immunology و ال .. ال .. حيكون
+
+38
+00:03:05,160 --> 00:03:10,320
+ضمن المساقن ان شاء الله flashات و صور و فيديوهات
+
+39
+00:03:10,320 --> 00:03:14,040
+ان شاء الله هنزودكم فيها او روابط لها حتى تحضروها
+
+40
+00:03:14,040 --> 00:03:16,740
+و تستفيدوا منها ان شاء اللهبالنسبة للدرجات و هذا
+
+41
+00:03:16,740 --> 00:03:21,700
+الموضوع اللى بهمكوا كتير الامر كالعادى يعنى ال
+
+42
+00:03:21,700 --> 00:03:26,540
+midterm عادي 25 درجة ال final exam 60 درجة ال
+
+43
+00:03:26,540 --> 00:03:30,780
+attendance خمس درجات و ال quizzes عشر درجات و لو
+
+44
+00:03:30,780 --> 00:03:33,860
+مااخدناش ال quizzes هنضم العشرة درجات للمين لل
+
+45
+00:03:33,860 --> 00:03:35,360
+midterm ان شاء الله لل midterm
+
+46
+00:03:38,090 --> 00:03:43,190
+محتوى المساق محتوى غزير ومحتوى رائع جدا وانا اود
+
+47
+00:03:43,190 --> 00:03:48,550
+ان اقدم يعني تقديم بسيط لهذا المساق يمكن من اضعف
+
+48
+00:03:48,550 --> 00:03:55,070
+النقاط في مجال التحليل الطبية في قطاع غزة ومجال ال
+
+49
+00:03:55,070 --> 00:04:01,430
+virusلماذا أضعف النقطة؟ لأن التكلفة تبع الزراعة
+
+50
+00:04:01,430 --> 00:04:07,250
+تحت الفيروسات عالية وغير متوفرة في معظم المؤسسات
+
+51
+00:04:07,250 --> 00:04:11,110
+الصحية، حتى الجامعات ومنها جامعتنا، فقط بنوفرها
+
+52
+00:04:11,110 --> 00:04:16,510
+لما نمل دراسة، ولكن ليس على شكل روتيني، وبالتالي
+
+53
+00:04:16,510 --> 00:04:20,730
+نحن بحاجة إلى تطوير هذا المجالولا يمكن أن نطول هذا
+
+54
+00:04:20,730 --> 00:04:24,990
+المجال فقط بشراء أجهزة ومعدات ومواد وإنما يجب أن
+
+55
+00:04:24,990 --> 00:04:27,930
+نطول الكوادر البشرية اللي هي مثل حضراتكم فهذا
+
+56
+00:04:27,930 --> 00:04:31,410
+المثاق هيجتمل ان شاء الله على كام كبير من
+
+57
+00:04:31,410 --> 00:04:34,870
+المعلومات صحيح بصعب .. بصعب عليكم في الامتحان لكن
+
+58
+00:04:34,870 --> 00:04:39,110
+الآخر بيطلن منها وناس مؤهلين بشكل جيد ان شاء الله
+
+59
+00:04:39,110 --> 00:04:43,350
+أنا قسمت المثاق إلى قسمين قسم part one و part two
+
+60
+00:04:43,350 --> 00:04:46,950
+part one هو ال basic virology و ال part two هو ال
+
+61
+00:04:46,950 --> 00:04:51,490
+clinical virologyطبعا ال basic صعب علينا نتكلم عن
+
+62
+00:04:51,490 --> 00:04:56,190
+طب و عن أمراض فيروسية دون أننا نعرف التفاصيل عن
+
+63
+00:04:56,190 --> 00:05:00,370
+الفيروسات و صفاتها و تركيبها و طريقة تكاثرها
+
+64
+00:05:00,370 --> 00:05:03,770
+بالضبط زي ما أخدنا في البكتيريا أخدنا essential و
+
+65
+00:05:03,770 --> 00:05:05,870
+medical و بعدين أخدنا diagnostic و micro و اقبل
+
+66
+00:05:05,870 --> 00:05:09,790
+فانا فيه basic virology ال structure تبع الفيروسات
+
+67
+00:05:09,790 --> 00:05:13,310
+ال replication و ال replication تبع الفيروس أصلا
+
+68
+00:05:13,310 --> 00:05:15,950
+بميزه عن باقي المخلوقات و هنتكلم عنه بعد قليل
+
+69
+00:05:16,620 --> 00:05:19,620
+Genetic and gene therapy، يا هل ترى الفيروسات
+
+70
+00:05:19,620 --> 00:05:24,060
+يحكمها نفس ما يحكم البكتيريا والإنسان من مادة
+
+71
+00:05:24,060 --> 00:05:29,500
+وراثية ونظم للوراثة، هذا ما سنتعرف عليه إن شاء
+
+72
+00:05:29,500 --> 00:05:32,540
+الله في هذا الفصل Classification of medically
+
+73
+00:05:32,540 --> 00:05:38,680
+important virusesزي ما في بكتيريا مفيدة و بكتيريا
+
+74
+00:05:38,680 --> 00:05:42,500
+ضارة و زي ما في بكتيريا ممرضة و بكتيريا محتملها
+
+75
+00:05:42,500 --> 00:05:46,480
+تكون ممرضة، أيضا البيروسات لا نستطيع أن نقول عنها
+
+76
+00:05:46,480 --> 00:05:50,600
+كلها medically important، في كتير منها بالعكس
+
+77
+00:05:50,600 --> 00:05:54,300
+medically important من ناحية عكسية، نحن نستخدمها
+
+78
+00:05:54,300 --> 00:05:57,420
+في قتل البكتيريا، على سبيل المثال زي ال
+
+79
+00:05:57,420 --> 00:06:02,480
+bacteriophagesيعني مثلا كعلاج مش كفيه فيروسات
+
+80
+00:06:02,480 --> 00:06:05,640
+بتصيبش الإنسان بتصيب الحيوان فيه بتصيبش الإنسان
+
+81
+00:06:05,640 --> 00:06:09,300
+والحيوان فيه بتصيب النباتات وبتالي فيه فيروسات
+
+82
+00:06:09,300 --> 00:06:16,380
+بالفعل لاتهمن سريريا أو طبيا هذا الفيروس الذي
+
+83
+00:06:16,380 --> 00:06:20,820
+نختلف على ما إذا كان أصلا كائن حي أو غير كائن حي
+
+84
+00:06:22,900 --> 00:06:28,600
+كيف له أن يحدث مرض للإنسان؟ ما الذي يؤهله؟ ما هي
+
+85
+00:06:28,600 --> 00:06:32,900
+مكوناته؟ ما هي جيناته؟ ما هي إنزيماته؟ كيف له أن
+
+86
+00:06:32,900 --> 00:06:38,510
+يحدث مرض؟ هذا بيسميه pathogenesisكيف لرسم الإنسان
+
+87
+00:06:38,510 --> 00:06:42,050
+أن يتقي هذا الفيروس و أن يكافحه و أن هثير بالمرض
+
+88
+00:06:42,050 --> 00:06:47,190
+بال influenza وهي فيروس و بالرشح وهي فيروس و نشفى
+
+89
+00:06:47,190 --> 00:06:51,370
+تلقائيا دون ما تدخل علاجي يبقى في عندنا host
+
+90
+00:06:51,370 --> 00:06:55,530
+defense يعني في عندنا مناعة ضد الفيروسات كيف لهذه
+
+91
+00:06:55,530 --> 00:06:59,710
+المناعة أو كيف تعمل هذه المناعةالـ laboratory
+
+92
+00:06:59,710 --> 00:07:04,250
+diagnosis تشخيص المخبري للفيروسات قاعدين نتكلم على
+
+93
+00:07:04,250 --> 00:07:08,990
+ضعف شديد في هذا المجال antiviral drugs و أنا سأكون
+
+94
+00:07:08,990 --> 00:07:13,630
+يعني خفيف معاكم في هذا الجانب لإنه كام من العقاقير
+
+95
+00:07:13,630 --> 00:07:19,410
+عالي جدا و أسماءها صعبة فهنكتفي في غالبا بأسماء
+
+96
+00:07:19,410 --> 00:07:24,550
+العائلات تبع هذه العقاقير الوصول الأخير من ال part
+
+97
+00:07:24,550 --> 00:07:30,340
+one اللي هو ال viral vaccinesيعني شرر الأطفال أعلن
+
+98
+00:07:30,340 --> 00:07:33,880
+قبل عامين أن فلسطين خالية من شرر الأطفال من قبل
+
+99
+00:07:33,880 --> 00:07:38,260
+مرضى الصحة العالمية شرر الأطفال مرض فيروسي كيف
+
+100
+00:07:38,260 --> 00:07:42,980
+تخلص العالم من هذا المرض الفيروسي من خلال التطعمات
+
+101
+00:07:42,980 --> 00:07:47,700
+اللي هي ال vaccines بتسمعوا بال smallpox smallpox
+
+102
+00:07:47,700 --> 00:07:50,760
+اللي هو الجدري مش الجدري اللي بتعرفوه انتوا جدر
+
+103
+00:07:50,760 --> 00:07:56,340
+الماء أو بيسموه chickenpox لأ هذا جدري
+
+104
+00:07:57,160 --> 00:08:02,180
+تم القضاء عليه ايضا من خلال من خلال تطعيمات و
+
+105
+00:08:02,180 --> 00:08:06,340
+تطعيمات كانت فعالة جدا لدرجة انه بالفعل اخر حالة
+
+106
+00:08:06,340 --> 00:08:10,600
+سجلت كانت في العام الف وتسعمائة وتسعة وسبعين لمريض
+
+107
+00:08:10,600 --> 00:08:15,660
+سوداني اصيب بهذا المرض الخبيث و تم القضاء عليه اذا
+
+108
+00:08:15,660 --> 00:08:20,840
+ال viral vaccines مهمة جدا جدا في عملية التخلص
+
+109
+00:08:20,840 --> 00:08:25,860
+منها من الأمراض الفيروسية ال part two هلاجي اول
+
+110
+00:08:25,860 --> 00:08:30,760
+اربع عنوينDNA envelope viruses DNA non envelope
+
+111
+00:08:30,760 --> 00:08:36,060
+viruses RNA envelope وRNA non envelope ايش التصنيف
+
+112
+00:08:36,060 --> 00:08:41,020
+هذه العجيبة؟ عندنا تصنيف للمادة الوراطية الفيروسات
+
+113
+00:08:41,020 --> 00:08:47,580
+يا جماعة يا اما DNA يا اما RNA لكن ليس كلاهما
+
+114
+00:08:47,580 --> 00:08:53,440
+لايوجد داخل الفيروس اتنيناللي هم ال DNA و ال RNA،
+
+115
+00:08:53,440 --> 00:08:57,100
+يا إما RNA يا إما DNA، و أصلا لا يوجد في الدنيا
+
+116
+00:08:57,100 --> 00:09:01,440
+مخلوقات بنعرفها المادة الوراثية تبعتها RNA إلا من؟
+
+117
+00:09:01,440 --> 00:09:06,460
+إلا الفيروس، اللي أنا صففنا based on DNA أو RNA،
+
+118
+00:09:06,460 --> 00:09:12,560
+في كمان تصنيف، في بعض الفيروسات تنتلك envelopeغلاف
+
+119
+00:09:12,560 --> 00:09:17,300
+خارجي تمام؟ بنسميه envelope فاللي تمتلك هذا الغلاف
+
+120
+00:09:17,300 --> 00:09:21,420
+بنسميها enveloped واللي ما تمتلكه بنسميها non
+
+121
+00:09:21,420 --> 00:09:27,140
+-enveloped أو nakedتمام؟ يا اما naked يا اما non
+
+122
+00:09:27,140 --> 00:09:30,080
+-enveloped فالان بالظبط زي ما كنا في البكتيريا
+
+123
+00:09:30,080 --> 00:09:32,800
+نقول gram positive و gram negative و نقول بصي لاي
+
+124
+00:09:32,800 --> 00:09:37,040
+و نقول كوكساي هلق نقول DNA viruses يا اما
+
+125
+00:09:37,040 --> 00:09:40,180
+enveloped يا اما non-enveloped RNA enveloped او
+
+126
+00:09:40,180 --> 00:09:44,940
+non-enveloped إذا تصنيفة سهلة لهذه الفيروسات انا
+
+127
+00:09:44,940 --> 00:09:48,560
+كمان مجموعة مهمة جدا من الفيروسات تسمى Hepatitis
+
+128
+00:09:48,560 --> 00:09:55,580
+virusesلا تمتلك مقومات الشراكة في مجموعة إلا مقوم
+
+129
+00:09:55,580 --> 00:10:00,260
+واحد، إيش هو هذا المقوم؟ إنها كلها بتصيب الكبد،
+
+130
+00:10:00,260 --> 00:10:04,080
+يعني ال target تبعها الكبد، أعطيكوا أمثلة،
+
+131
+00:10:04,080 --> 00:10:09,980
+Hepatitis A تختلف تقريبا عن B تختلف تقريبا عن C،
+
+132
+00:10:09,980 --> 00:10:14,110
+في ال structure و في العائلةلكن بنسميها Hepatitis
+
+133
+00:10:14,110 --> 00:10:17,970
+A و Hepatitis B و Hepatitis C لإن كلهم بيشتركوا
+
+134
+00:10:17,970 --> 00:10:22,430
+بيصيبوا مين اللي هو الكلمة طبعا هم صاروا ستة الآن
+
+135
+00:10:22,430 --> 00:10:28,030
+Hepatitis A و B و C و D أو Delta و فيه هنا E و فيه
+
+136
+00:10:28,030 --> 00:10:31,710
+هنا G يبقى فيه هنا مجموعة كبيرة من الفيروسات
+
+137
+00:10:31,710 --> 00:10:37,010
+سميناهم Hepatitis Virus في مجموعة أخرى كمان مهمة
+
+138
+00:10:37,010 --> 00:10:41,680
+اسمها Arboviruses و Arbo جاية من كلمةأرثروبود
+
+139
+00:10:41,680 --> 00:10:45,400
+والأرثروبود مرض عليكم قبل هيك مفصليات الأرض
+
+140
+00:10:45,400 --> 00:10:52,960
+الحشرات يعني و بو born ف ar اللي هى r هدى عبارة عن
+
+141
+00:10:52,960 --> 00:11:00,600
+أرثرو والجندل بي وال او هى من born كلمة born لما
+
+142
+00:11:00,600 --> 00:11:03,740
+نقول food born diseases الأمراض المنتقلة عن طريق
+
+143
+00:11:03,740 --> 00:11:09,050
+الغذاءأرثروبود born diseases الأمراض المنتقلة عن
+
+144
+00:11:09,050 --> 00:11:14,150
+طريق الحشرات، أربو فيروسات هي فيروسات تنتقل عن
+
+145
+00:11:14,150 --> 00:11:19,470
+طريق من الحشرات، تسمعوا أن الفيروسات بتسبب سرطان؟
+
+146
+00:11:20,300 --> 00:11:24,000
+مين هدول معانا اليوم الدراسة اللي عملناها لل .. لل
+
+147
+00:11:24,000 --> 00:11:28,740
+.. السرطان؟ أنا عملت محاضرة وتحدثت على إن ما نسبته
+
+148
+00:11:28,740 --> 00:11:33,320
+حوالي عشرين بالمائة من السرطانات اللي بتصيب البشر
+
+149
+00:11:33,320 --> 00:11:39,800
+سببها micro organismبكتيريا او فيروسات او طوفيليات
+
+150
+00:11:39,800 --> 00:11:45,600
+الناس بلا بأس بها من السرطانات تحدثها micro
+
+151
+00:11:45,600 --> 00:11:49,180
+organism منها الفيروسات هذه الفيروسات احنا بنسميها
+
+152
+00:11:49,180 --> 00:11:54,920
+tumor viruses يعني الفيروسات التي تنتج الأورامل
+
+153
+00:11:54,920 --> 00:11:59,360
+ومن ضمن هذه الأورامل هي السرطانة في مجموعة أخرى
+
+154
+00:11:59,360 --> 00:12:05,000
+اسمها slowviruses and prions كلمة slow viruses
+
+155
+00:12:05,000 --> 00:12:11,860
+توحي بأن الفيروس بطيء أو المرض اللي يسببه الفيروس
+
+156
+00:12:11,860 --> 00:12:16,660
+بيعمل slow progression يعني تقدمه في الإنسان بيكون
+
+157
+00:12:16,660 --> 00:12:21,220
+بطيء بده سنوات حتى يحدث هذا المرض هذا الشق الأول
+
+158
+00:12:21,220 --> 00:12:25,220
+من الموضوع الشق التاني اللي هي ال prions ال prions
+
+159
+00:12:25,220 --> 00:12:30,110
+يا بنات احنا يعني لما زمان زمانجابل الميكروسكوبات
+
+160
+00:12:30,110 --> 00:12:33,510
+الشيء الوحيد اللي كنا نعرفه انه parasite هو
+
+161
+00:12:33,510 --> 00:12:36,750
+الحشرات الكبيرة زي الجمل اللي كنا نشوفها اما على
+
+162
+00:12:36,750 --> 00:12:41,730
+الرأس او على الاسم طورنا شوية صار ان الميكروسكوبات
+
+163
+00:12:41,730 --> 00:12:46,150
+صاروا ناعرة في ال bacteria لما اكتشفنا ال virus
+
+164
+00:12:46,150 --> 00:12:51,870
+كانت نقلة نوعية في المعارفة البشرية ان في مخلوقات
+
+165
+00:12:51,870 --> 00:12:57,140
+اصغر من مين من ال bacteriaفي تسينات القرن الماضي
+
+166
+00:12:57,140 --> 00:13:04,020
+اكتشفنا ان في اصلا مادة معضية ليس لها اي خصائص
+
+167
+00:13:04,020 --> 00:13:08,800
+حياة ليه ال bryons اللي بتسبب مرض جنون البقر
+
+168
+00:13:08,800 --> 00:13:16,540
+بالمناسبة في مرض جنون البشر يعني المقابل له ال
+
+169
+00:13:16,540 --> 00:13:20,620
+bryons عبارة عن مجموعة من البروتينات normally
+
+170
+00:13:20,620 --> 00:13:25,230
+found in our bodies يعني مولودة فينا احنابس بتكون
+
+171
+00:13:25,230 --> 00:13:31,650
+normal ونفترض شكلها هيك هذا normal إذا اتحول إلى
+
+172
+00:13:31,650 --> 00:13:37,550
+شكل آخر بتصير abnormal كيف تتكاتر هذه ال abnormal
+
+173
+00:13:37,550 --> 00:13:43,810
+بيلتقي مع ال normal بيخليه abnormal بمعنى آخر هو
+
+174
+00:13:43,810 --> 00:13:48,480
+بتكاترش تكاتر فعلي وإنما بيحولالـ Normal إلى
+
+175
+00:13:48,480 --> 00:13:52,360
+Abnormal فبكتر من مين؟ من الـ Abnormal وكانوا قاعد
+
+176
+00:13:52,360 --> 00:13:57,820
+بتكاتر وهذا اسمه protein infectious واقتصرناهم
+
+177
+00:13:57,820 --> 00:14:02,760
+واسميناهم Prions إذن الـ Prions هي ليست مخلوقات
+
+178
+00:14:02,760 --> 00:14:07,100
+حية وإنما مخلوقات غير حية هي عبارة عن protein لا
+
+179
+00:14:07,100 --> 00:14:13,380
+تحتوي على مادة وراثية ألبس النقطة
+
+180
+00:14:13,380 --> 00:14:18,520
+اللي بعديها Human Immunodeficiency Virusاللي هو
+
+181
+00:14:18,520 --> 00:14:23,220
+مرض أو فيروس عواز المناع أو نقص المناع اللي هو ال
+
+182
+00:14:23,220 --> 00:14:27,740
+aids فيروس ال aids وكلكم
+
+183
+00:14:27,740 --> 00:14:32,800
+بتعرفوا أن هذا الفيروس منذ اكتشافه أجريت عليه
+
+184
+00:14:32,800 --> 00:14:37,120
+دراسات عديدة لدرجة أن هذه الدراسات كانلها أثر كبير
+
+185
+00:14:37,120 --> 00:14:41,980
+في تطور علم ال biology وعلم ال immunology بشكل عام
+
+186
+00:14:43,340 --> 00:14:46,400
+على الرغم ان احنا لحد دلان مااتشفناش علاج فعال
+
+187
+00:14:46,400 --> 00:14:52,780
+للفيروس يعني في علاجات لكن مش ناجعة تماما في
+
+188
+00:14:52,780 --> 00:14:58,520
+القضاء عليه ولا قدرنا نحصل vaccine يمنع حدوث هذا
+
+189
+00:14:58,520 --> 00:15:02,440
+المرض إلا أن الدراسات المصاحبة بالفعل سهمت في
+
+190
+00:15:02,440 --> 00:15:07,730
+تطوير علم المناعة وعلم الفيروسةو طبعا بتعرفوا كل
+
+191
+00:15:07,730 --> 00:15:11,150
+سنة بيحتفلوا بيوم ال .. بيوم ال aids العالمي دلالة
+
+192
+00:15:11,150 --> 00:15:16,330
+على أن هذا المرض ما زال بيحتل مكانة كبيرة في الطب
+
+193
+00:15:16,330 --> 00:15:19,570
+في العالم والنقطة الأخيرة إذا أسعفنا الوقت اللي هي
+
+194
+00:15:19,570 --> 00:15:23,530
+ال minor viral pathogen كلمة minor viral pathogen
+
+195
+00:15:23,530 --> 00:15:30,150
+مصطلح فاضفاض ليس مصطلح دقيق فبنحاول نفسرلكم إيه ما
+
+196
+00:15:30,150 --> 00:15:34,810
+المقصود فيه لو عرفنا أنه منطقة ما جغرافية في
+
+197
+00:15:34,810 --> 00:15:39,830
+العالمبيحدث فيها وباء بفيروس محدد ولا ينتقل هذا
+
+198
+00:15:39,830 --> 00:15:45,290
+الفيروس إلى أي دولة تانية هذا بيعتبره minor بيحصل
+
+199
+00:15:45,290 --> 00:15:51,030
+مثلا كل عشرين سنة وباء محدود بيسموه minor لكن ما
+
+200
+00:15:51,030 --> 00:15:55,870
+رأيكم باسم West Nile Virus West Nile حمال نيل
+
+201
+00:15:55,870 --> 00:16:00,430
+الغربي صح؟ ايش يعني حمال نيل الغربي؟ يعني حمى
+
+202
+00:16:00,430 --> 00:16:06,200
+اكتشفوها في منطقات حوض النيل الغربيطب هاد ال .. ال
+
+203
+00:16:06,200 --> 00:16:07,840
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+204
+00:16:07,840 --> 00:16:08,020
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+205
+00:16:08,020 --> 00:16:08,060
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+206
+00:16:08,060 --> 00:16:08,320
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+207
+00:16:08,320 --> 00:16:08,340
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+208
+00:16:08,340 --> 00:16:14,220
+ال .. ال .. ال ..
+
+209
+00:16:14,220 --> 00:16:19,320
+ال ..
+
+210
+00:16:19,320 --> 00:16:19,340
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+211
+00:16:19,340 --> 00:16:19,620
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+212
+00:16:19,620 --> 00:16:19,620
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+213
+00:16:19,620 --> 00:16:19,620
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+214
+00:16:19,620 --> 00:16:19,940
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+215
+00:16:19,940 --> 00:16:20,160
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+216
+00:16:20,160 --> 00:16:20,160
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+217
+00:16:20,160 --> 00:16:31,700
+.. ال .. ال ..
+
+218
+00:16:32,620 --> 00:16:37,320
+التغير المناخي اللي حاصل في العالم بلدان كانت أصلا
+
+219
+00:16:37,320 --> 00:16:41,680
+حارة اليوم صارت معتدلة انت بتعرف ان بريطانيا زرع
+
+220
+00:16:41,680 --> 00:16:46,800
+فيها زيتون قبل كام سنة نجحها في زراعة زيتون طبعا
+
+221
+00:16:46,800 --> 00:16:49,620
+الزيتون كان حلم ان ينزلها في وين في بريطانيا انه
+
+222
+00:16:49,620 --> 00:16:53,080
+يعني هو بنزلها بس مافيحملش ثمر يعني فالقصد من
+
+223
+00:16:53,080 --> 00:16:57,200
+الكلام احنا في غزة هنا أصبح لدينا أنواع من البعوض
+
+224
+00:16:57,200 --> 00:17:02,270
+لم نكن نعرفها من قبل سموها tiger mosquitoاللي
+
+225
+00:17:02,270 --> 00:17:06,610
+بتكون مخططة زي ال .. و لساعتها مزعجة جدا اعتقد
+
+226
+00:17:06,610 --> 00:17:10,590
+بيسموها Aedes Aegypticus او الزعجة المصرية يعني هي
+
+227
+00:17:10,590 --> 00:17:18,310
+بعوضة من مصر هذا التغير في المناخ و سهولة السفر
+
+228
+00:17:18,310 --> 00:17:23,170
+أصبح او جعل من إمكانية انتقال الأمراض من مكان
+
+229
+00:17:23,170 --> 00:17:28,300
+جغرافي إلى آخر إمكانية عاليةكلمة minor الآن هي
+
+230
+00:17:28,300 --> 00:17:32,860
+minor لكن في المستقبل قد تكون major ومنتشرة بشكل
+
+231
+00:17:32,860 --> 00:17:37,160
+كام طيب
+
+232
+00:17:37,160 --> 00:17:43,020
+.. الآن مانفعش أنه ندخل على الفيروسات وعلى الطب
+
+233
+00:17:43,020 --> 00:17:47,420
+تبع الفيروسات دون ما معرفة ماهي .. ماهية
+
+234
+00:17:47,420 --> 00:17:54,390
+الفيروسات، بنتفق عليها تماماأول نقطة أساسية تميز
+
+235
+00:17:54,390 --> 00:17:58,110
+الفيروسات عن باقي المخلوقات their obligate
+
+236
+00:17:58,110 --> 00:18:02,810
+intracellular replication حد هيقوللي دارس
+
+237
+00:18:02,810 --> 00:18:05,210
+diagnostic microbial يقوللي دكتور ماحنا درسنا
+
+238
+00:18:05,210 --> 00:18:10,290
+تنتين بكتيريا الكلاميديا والريكيزيا التنتين
+
+239
+00:18:10,290 --> 00:18:13,770
+obligate intracellular برضة كلامكوا صحيح هذا وجه
+
+240
+00:18:13,770 --> 00:18:18,630
+التشابه الوحيد بين هدول التنتين والفيروسات لكن
+
+241
+00:18:18,630 --> 00:18:23,610
+بالإضافة إلى هذه المعلومةإن ال replication of
+
+242
+00:18:23,610 --> 00:18:28,250
+viruses is so different from that of other
+
+243
+00:18:28,250 --> 00:18:33,310
+microorganisms، ليش؟ احنا capable من التكاتر عننا،
+
+244
+00:18:33,310 --> 00:18:37,490
+من الانقسام عننا، الخلية بتصير، بتنتهي، مصبوط؟
+
+245
+00:18:37,490 --> 00:18:42,930
+والبكتيريا كذلك الأمر، البكتيريا بالانقسام الثنائي
+
+246
+00:18:42,930 --> 00:18:47,310
+البسيط، احنا بالmyosis والmyotosis، صح ولا لأ؟لكن
+
+247
+00:18:47,310 --> 00:18:52,630
+الفيروسات بيدخل الفيروس داخل خلية بيطلع مئات
+
+248
+00:18:52,630 --> 00:18:58,070
+الفيروس يبقى طريقة التكاثر معاها unique فريدة
+
+249
+00:18:58,070 --> 00:19:02,710
+متميزة متفردة عن باقي المخلوقات إذا obligate
+
+250
+00:19:02,710 --> 00:19:08,070
+intracellular parasite رقم اتنين they reproduce in
+
+251
+00:19:08,070 --> 00:19:10,870
+a manner different from that dose of prokaryotes
+
+252
+00:19:10,870 --> 00:19:13,610
+and eukaryotes يعني مش زي الخلايا
+
+253
+00:19:16,370 --> 00:19:20,650
+طبعاً هدولا النقطتين مهمين جدا لكن النقطة اللي أهم
+
+254
+00:19:20,650 --> 00:19:26,970
+من ذلك المحتوى الوراثي المحتوى الوراثي ذكرنا قبل
+
+255
+00:19:26,970 --> 00:19:32,530
+قليل أنه الفيروسات تحتوي مادة وراثية يا إما DNA يا
+
+256
+00:19:32,530 --> 00:19:37,950
+إما RNA but never both بينما كل المخلوقات الأخرى
+
+257
+00:19:37,950 --> 00:19:43,470
+تحتوي على كل من ال DNA و ال RNA إذا هذا فرق أساسي
+
+258
+00:19:43,470 --> 00:19:49,540
+ومهم جدابعض الفيروسات تمتلك ما يسمى بال envelope
+
+259
+00:19:49,540 --> 00:19:53,040
+اللي احنا نقول عنها enveloped viruses من وين هذا
+
+260
+00:19:53,040 --> 00:19:57,440
+ال envelope جاي؟ تخيلوا معايا هاي الفيروس وهي ال
+
+261
+00:19:57,440 --> 00:20:02,740
+cell membrane بتاع الخلية ال host الفيروس هو طالع
+
+262
+00:20:02,740 --> 00:20:09,220
+بياخد جزء من ال membrane بيقطعه و بطلع فيه برا فال
+
+263
+00:20:09,220 --> 00:20:12,820
+membrane هذا الآن صار مين محيط بال virus لاحظوا
+
+264
+00:20:12,820 --> 00:20:19,330
+شغلة ان وجود هذا ال membraneإله مزايا وإله عيوب
+
+265
+00:20:19,330 --> 00:20:25,610
+إيش مزايا بتتوقعوا؟ مدام هو جزء من ال horse cell
+
+266
+00:20:25,610 --> 00:20:31,610
+لو بديعمل infection لخلية تانية مابيحتاجش إلى
+
+267
+00:20:31,610 --> 00:20:36,190
+receptors بس بيعمل fusion بيرتبط ال membrane مع ال
+
+268
+00:20:36,190 --> 00:20:41,630
+membrane و الفيروس يدخل جوا بكل سهولة صح؟ هذا رقم
+
+269
+00:20:41,630 --> 00:20:46,590
+واحد، هذا رقم اتنين جهاز المناعة بتعرفش عليه، ليش؟
+
+270
+00:20:47,110 --> 00:20:52,150
+ما هو جزء من مين؟ من الهواص، سرق، إذا في مستين،
+
+271
+00:20:52,150 --> 00:20:56,570
+إنه دخوله للخلايا بيصير سهل و بيهرب من مين؟ من
+
+272
+00:20:56,570 --> 00:21:00,690
+جهاز المناقة، طب إيش هيوبه؟ لو خرج إلى الخارج،
+
+273
+00:21:00,690 --> 00:21:07,230
+خارج الجسم، على الأسطح مثلا، وجف قليلا، بيخرب ال
+
+274
+00:21:07,230 --> 00:21:13,570
+virusلو استخدمنا أي مادة مذيبة للدهون زي الكحول
+
+275
+00:21:13,570 --> 00:21:18,530
+البسيط بيدمر ال cell membrane إذا دمر ال cell
+
+276
+00:21:18,530 --> 00:21:21,170
+membrane اللي هو ال envelope بيبطل الفيروس قادر
+
+277
+00:21:21,170 --> 00:21:26,430
+على مين؟ على الإرتباط ودخول الخلايا، إذا خدنا نقول
+
+278
+00:21:26,430 --> 00:21:30,170
+إنه إله مزايا داخل الجسم وإله عيوب خارج الجسم إنه
+
+279
+00:21:30,170 --> 00:21:35,530
+environmentally مش stableيعني غير قادر على ثبات
+
+280
+00:21:35,530 --> 00:21:42,570
+لفترات طويلة في البيئة أدللكم بمثال بسيط، بتعرفوا
+
+281
+00:21:42,570 --> 00:21:46,070
+الفيروس اللي بيعمل أمراض في ال intestine، في
+
+282
+00:21:46,070 --> 00:21:50,410
+القمعة يعني، مثلا زي الإسهادط، زي ال rotavirus، لو
+
+283
+00:21:50,410 --> 00:21:53,690
+تخيلنا هذا إله envelope، و أحنا أكلناه، when
+
+284
+00:21:53,690 --> 00:21:58,570
+هيمور؟ع المعدة المعدة فيها حامض الحامض مش بيعمل
+
+285
+00:21:58,570 --> 00:22:04,570
+بيذيب الدهون فمستحيل اللاجي فيروس بيعمل
+
+286
+00:22:04,570 --> 00:22:11,030
+gastroenteritis ويكون له envelope وصل الصورة ال
+
+287
+00:22:11,030 --> 00:22:15,390
+envelope بيعطيه instability ايش هال instability؟
+
+288
+00:22:15,390 --> 00:22:19,890
+عدم استقرار وعدم ثبت بينما الفيروسات اللي مالهاش
+
+289
+00:22:19,890 --> 00:22:25,840
+envelope غالبا بتكون ثابتة في البيتوكل الفيروسات
+
+290
+00:22:25,840 --> 00:22:30,140
+اللى بتعمل gastrointestinal tract infection مالهاش
+
+291
+00:22:30,140 --> 00:22:39,720
+envelope فى فيروس شهير صديق لكم فيروس رussia هذا
+
+292
+00:22:39,720 --> 00:22:46,400
+صغير جدا ولا يمتلك envelope وعدم امتلاكه envelope
+
+293
+00:22:46,400 --> 00:22:53,450
+لو عطصنا وعلى الطاولة هذهجافة ولا لأ؟ الأصل لو انه
+
+294
+00:22:53,450 --> 00:22:57,910
+.. انه .. لو إله انفله بيحصل فيه بيجف وبيتدمر
+
+295
+00:22:57,910 --> 00:23:01,910
+بينما لإنه مالوش فبيبقى لفترات طويلة بيجي حاضرة
+
+296
+00:23:01,910 --> 00:23:05,450
+واحد بيمسك الطاولة هادى وبعد شوية بيحك عينه أو
+
+297
+00:23:05,450 --> 00:23:10,630
+بيحك أنفه أو بيتناول طعام بي .. بيت .. بينتقل ال
+
+298
+00:23:10,630 --> 00:23:14,590
+microbe من ال surfaces إلى الإنسان لإنه
+
+299
+00:23:14,590 --> 00:23:19,750
+environmentally stable مالوش انفل تمام؟
+
+300
+00:23:22,610 --> 00:23:27,550
+بالنسبة للفروقات الأخرى ما بين ال virus و ال other
+
+301
+00:23:27,550 --> 00:23:32,390
+cells كل الخلايا ماعدل البكتيريا طبعا تحتوي على
+
+302
+00:23:32,390 --> 00:23:36,970
+نواة حقيقية الفيروس ماعودش نواة كل الخلايا ماعدل
+
+303
+00:23:36,970 --> 00:23:41,650
+البكتيريا عندها mitochondria بينما الفيروسات
+
+304
+00:23:41,650 --> 00:23:46,670
+ماعندهاش أي شيء ribosomes البكتيريا و ال other
+
+305
+00:23:46,670 --> 00:23:51,170
+cells عندهم ribosomes لكن الفيروسات ماعندهاش
+
+306
+00:23:52,430 --> 00:23:57,970
+البيروس لا يمتلك من مقومات الخلايا الحية إلا حاجة
+
+307
+00:23:57,970 --> 00:24:01,730
+واحدة قدرته على ال replication يا جماعة قدرته على
+
+308
+00:24:01,730 --> 00:24:08,090
+ال replication وهي محدودة وين في host يعني مش برا
+
+309
+00:24:08,090 --> 00:24:10,950
+زي البكتيريا البكتيريا تقدر تعيش معيشة حرة هذا
+
+310
+00:24:10,950 --> 00:24:17,630
+بعيش معيشة حرة قلبهاالجدول البسيط بيحاول انه يفرق
+
+311
+00:24:17,630 --> 00:24:21,510
+ما بين طبعا تلخيص لما ذكرناه لكن لبس ان نمر عليهم
+
+312
+00:24:21,510 --> 00:24:27,730
+مرور بشكل سريع المادة الوراثية ال viruses يكون يا
+
+313
+00:24:27,730 --> 00:24:32,410
+اما DNA يا اما RNA بينما الخلايا كل من ال DNA و ال
+
+314
+00:24:32,410 --> 00:24:36,010
+RNA موجودين بالنسبة لل proteins في الفيروسات
+
+315
+00:24:36,010 --> 00:24:42,230
+موجودة لكن قليلة بينما يعني عماد تكوين الخلايا
+
+316
+00:24:42,230 --> 00:24:46,120
+الأخرىغالبا بيكون من مين؟ من ال protein فلازم تكون
+
+317
+00:24:46,120 --> 00:24:51,280
+كثيرة ايضا عندنا ال lipoprotein membrane ال
+
+318
+00:24:51,280 --> 00:24:54,740
+lipoprotein membrane في الخلايا العادية بيكون
+
+319
+00:24:54,740 --> 00:24:57,540
+موجود بكثرة سواء كان في النواء او في ال cell
+
+320
+00:24:57,540 --> 00:25:01,860
+membrane بينما في ال viruses لم نجده الا في ال
+
+321
+00:25:01,860 --> 00:25:06,700
+enveloped viruses ومأخوض من مين؟ من ال host cell
+
+322
+00:25:06,700 --> 00:25:09,600
+يعني مش هو اللي بيصنعه مأخوض ايضا من ال host cell
+
+323
+00:25:10,260 --> 00:25:13,820
+الريبوزومس بيقولنا غير موجودة في الفيروسات بس في
+
+324
+00:25:13,820 --> 00:25:19,380
+إشارة خدوا بالك جنب كلمة absent و تحت الجدول في
+
+325
+00:25:19,380 --> 00:25:25,760
+تعليق عليها بيقولكوا إستثناء واحد لفيروس اسمه
+
+326
+00:25:25,760 --> 00:25:32,740
+Arena virus و Arena من حلبة حلبة بجد تكون المفروضة
+
+327
+00:25:32,740 --> 00:25:36,870
+بالرملوسموا الفيروس هذا لما شافوا تحت ال
+
+328
+00:25:36,870 --> 00:25:40,710
+microscope لجوا انه فيه granules granules يعني
+
+329
+00:25:40,710 --> 00:25:44,610
+حبابية فذكرتهم باسم arena اللي هي الحلبة اللي فيها
+
+330
+00:25:44,610 --> 00:25:50,190
+الرمل تمام فسموه arena virus لما كشفوا عن ال .. ال
+
+331
+00:25:50,190 --> 00:25:54,170
+.. ال .. الحبابات هذه لجوها عبارة عن ribosomes
+
+332
+00:25:54,170 --> 00:25:57,330
+طبعا اللي على بعض يقولون انها non-functional ايش
+
+333
+00:25:57,330 --> 00:26:05,730
+يعني non-functional؟ يعني ملاك .. ملاك وظيفة؟يعني
+
+334
+00:26:05,730 --> 00:26:09,750
+غير فعالة مافيش فيها لكن احنا انا دايما بفضل مصطلح
+
+335
+00:26:09,750 --> 00:26:13,950
+ان احنا مش عارفين ايش فضل بيكون مافيش اشي بدون ..
+
+336
+00:26:13,950 --> 00:26:18,350
+بدون .. بدون .. بدون اشي لكن هذا غالبا بيكون احنا
+
+337
+00:26:18,350 --> 00:26:22,270
+لسه ماعرفناش الوظيفة تبعتها لكن عموما الفيروسات
+
+338
+00:26:22,270 --> 00:26:26,990
+كلها معادة هذا الفيروس لا تحتوي على ribosomes
+
+339
+00:26:26,990 --> 00:26:31,150
+بينما المخلوقات الأخرى كلها فيها ribosomes
+
+340
+00:26:31,770 --> 00:26:35,530
+الانزيمات هل تحتاج الفيروس ان يكون معاه انزيمات و
+
+341
+00:26:35,530 --> 00:26:41,510
+لا يحتاجه؟ هل يحتاج الفيروس ان يكون لديه جايب معه
+
+342
+00:26:41,510 --> 00:26:48,230
+انزيمات و لا بيحتاجه؟ طيب إذا افترضنا ان انزيمات
+
+343
+00:26:48,230 --> 00:26:53,260
+الخلية مابتقدريش الغرض انا بيالقعها هاي تمام؟و
+
+344
+00:26:53,260 --> 00:26:57,840
+لازمني انا طبعا في القاعات الأخرى ممكن يكون او
+
+345
+00:26:57,840 --> 00:27:03,680
+لأخرين بيحطولهم flash انا نفسي اكسبني الأخ المصور
+
+346
+00:27:03,680 --> 00:27:06,380
+هناك ومش حاطلي flash انا كل ما اجي هناك لازم اخد
+
+347
+00:27:06,380 --> 00:27:10,680
+معايا مين ال flash تبعي ففي بعض الانزيمات لا تجد
+
+348
+00:27:10,680 --> 00:27:15,700
+بغيات افهم بعض الفيروسات لا تجد بغياتها في مكونات
+
+349
+00:27:15,700 --> 00:27:20,210
+الخلية فبتحضر مكونات معاها جاهزةففي بعض الفيروس
+
+350
+00:27:20,210 --> 00:27:27,010
+تحتاج إلى بعض الانزمات لكن قليل جدا قليل جدا بينما
+
+351
+00:27:27,010 --> 00:27:31,870
+الخلايا الخلايا الانزمات يعني بدون انزمات مافيش
+
+352
+00:27:31,870 --> 00:27:35,990
+انا قلتلكم ان خلية بدون protein خلية محكم عليها
+
+353
+00:27:35,990 --> 00:27:43,270
+بالموت والانزمات كلها protein عملية الانقسام بال
+
+354
+00:27:43,270 --> 00:27:45,930
+binary vision او ال mitosis طبعا غير موجودة في
+
+355
+00:27:45,930 --> 00:27:48,830
+الفيروسات بينما موجودة في من؟ في الخلايا
+
+356
+00:27:52,160 --> 00:27:58,800
+ناخد فكرة و تصور عن حجوم البيروسات اذكركم
+
+357
+00:27:58,800 --> 00:28:01,780
+بالبكتيريا لما عملتوا gram stain و مثلين blue
+
+358
+00:28:01,780 --> 00:28:06,620
+stain و طلعتوا تحت الميكروسكوب و شوفتوا البكتيريا
+
+359
+00:28:06,620 --> 00:28:11,380
+كانت عبارة عن شحتة او نقطة gram positive او gram
+
+360
+00:28:11,380 --> 00:28:17,860
+negative وهذه يا بنات الحجم تبعها طول ال E.coli
+
+361
+00:28:17,860 --> 00:28:21,780
+عايز المثال 3 مايكرون عرضها ثمكة يعني
+
+362
+00:28:26,320 --> 00:28:34,620
+الميكرون ألف نانو متر الميكرون ألف نانو متر الف
+
+363
+00:28:34,620 --> 00:28:37,580
+نانو متر الف نانو متر الف نانو متر الف نانو متر
+
+364
+00:28:37,580 --> 00:28:37,600
+الف نانو متر الف نانو متر الف نانو متر الف نانو
+
+365
+00:28:37,600 --> 00:28:37,700
+متر الف نانو متر الف نانو متر الف نانو متر الف
+
+366
+00:28:37,700 --> 00:28:37,960
+نانو متر الف نانو متر الف نانو متر الف نانو متر
+
+367
+00:28:37,960 --> 00:28:40,800
+الف نانو متر الف نانو متر الف نانو متر الف نانو
+
+368
+00:28:40,800 --> 00:28:40,800
+متر الف نانو متر الف نانو متر الف نانو متر الف
+
+369
+00:28:40,800 --> 00:28:40,800
+نانو متر الف نانو متر الف نانو متر الف نانو متر
+
+370
+00:28:40,800 --> 00:28:40,800
+الف نانو متر الف نانو متر الف نانو متر الف نانو
+
+371
+00:28:40,800 --> 00:28:48,640
+متر الف نانو متر الف نانو متر الف نانو متر الف
+
+372
+00:28:48,640 --> 00:28:56,430
+نانويعني أشهر بالحجوم لازم نشوفها لازم نشوفها بس
+
+373
+00:28:56,430 --> 00:29:00,270
+خلّيني قبل ما نشوفها نعمل analogy analogy يعني
+
+374
+00:29:00,270 --> 00:29:05,810
+مقاربة بيقولنا أن أكبر بروتين تقريبا حجمه عشرين
+
+375
+00:29:05,810 --> 00:29:11,510
+نانومتر إذا في فيروسات تشابه في الحجم one single
+
+376
+00:29:11,510 --> 00:29:17,790
+proteinوأصغر المخلوقات الحية اللى بنعرفها احنا ال
+
+377
+00:29:17,790 --> 00:29:21,550
+microplasma فاكرينها؟ ال microplasma كبكتيريا هي
+
+378
+00:29:21,550 --> 00:29:27,410
+أصغر بكتيريا تقريبا 400 نانو نيتر أو 300 نانو نيتر
+
+379
+00:29:27,410 --> 00:29:33,520
+فبتقول انه أصغرحجم في الفيروسات يساوي اكبر حجم في
+
+380
+00:29:33,520 --> 00:29:38,200
+البروتينات و اكبر حادة في الفيروسات قد تشابه او قد
+
+381
+00:29:38,200 --> 00:29:45,020
+توازي اصغر بكتيداليال مايكو إبلاسما كيف نطلق
+
+382
+00:29:45,020 --> 00:29:51,860
+الأسماء على الفيروسات؟فيه أن مصطلح اسمه colloquial
+
+383
+00:29:51,860 --> 00:29:57,540
+terms وcolloquial terms يعني مصطلحات هبهزن عشوائية
+
+384
+00:29:57,540 --> 00:30:01,980
+يعني مما نراه نحن بالعامية مالاش أساس علم مثلا
+
+385
+00:30:01,980 --> 00:30:08,140
+بنقول عنها كوريات spheres أو rods عصويات أو مثل
+
+386
+00:30:08,140 --> 00:30:12,520
+الرصاصة على سبيل المثال أو مثل ال block تبع الطوب
+
+387
+00:30:12,520 --> 00:30:16,710
+تمام اللي بنبني فيه هذا bricksلكن واقع الأمر لو
+
+388
+00:30:16,710 --> 00:30:20,790
+دخلنا في التفاصيل الشكلية لهذه الفيروسات سنجد يا
+
+389
+00:30:20,790 --> 00:30:26,610
+بنات تركيب معقدة جدا ونظام .. خلّيني أسميه
+
+390
+00:30:26,610 --> 00:30:29,690
+geometrical symmetry إيش هي geometrical symmetry؟
+
+391
+00:30:29,690 --> 00:30:37,970
+تماثل هندسي دقيق جدا لهذه الفيروسة طبعا اللي بيعطي
+
+392
+00:30:37,970 --> 00:30:43,830
+التماثل الدقيق تركيب اسمه capsid ال capsid عبارة
+
+393
+00:30:43,830 --> 00:30:52,730
+عن proteinيحيط بالمادة الوراثية إذا الفيروس الكامل
+
+394
+00:30:52,730 --> 00:30:58,430
+قد يتكون فقط من قطعتين أو من جزئين مادة وراثية
+
+395
+00:30:58,430 --> 00:31:05,410
+نوكليو و من كابسيل و بيسموها نوكليو كابسيل الآن
+
+396
+00:31:05,410 --> 00:31:14,100
+هذا ال protein coat مش مكون منتركيب مختلفة مكون من
+
+397
+00:31:14,100 --> 00:31:21,920
+تركيب واحد متعدد اش يعني ايه؟ monomer اش هات
+
+398
+00:31:21,920 --> 00:31:27,340
+monomer؟ mono .. monomer يعني بروتين واحد اعطيكم
+
+399
+00:31:27,340 --> 00:31:30,560
+مثال بس عشان تخيلوا تعرف ال glul؟ اكيد ياخدوكوا
+
+400
+00:31:30,560 --> 00:31:36,200
+الصغار بلعبوا معاهم لو أخدنا حفنة من ال glul هاي و
+
+401
+00:31:36,200 --> 00:31:41,420
+رمناها على جهةو فجأة وجدناها قاعدة تتصفق فوق بعضها
+
+402
+00:31:41,420 --> 00:31:44,840
+و بتشكلي تركيبها .. انتوا إيش بتقولوا انتوا هذا
+
+403
+00:31:44,840 --> 00:31:50,700
+خيال علمي اه؟ مادة قادرة على انها تجمع ذاتها
+
+404
+00:31:50,700 --> 00:31:57,920
+بذاتها و بمصطلح بنسميه احنا self assembly assembly
+
+405
+00:31:57,920 --> 00:32:04,440
+تجميع self assembly الان هذا ما يحدث حقا في
+
+406
+00:32:04,440 --> 00:32:09,570
+الفيروساتالفيروسات لو احنا أخدنا المادة هذه
+
+407
+00:32:09,570 --> 00:32:12,890
+وحطناها في test tube لحالها بدون فيروس ولا بدون
+
+408
+00:32:12,890 --> 00:32:17,450
+مادة دولارتية هتجمع لوحدها بتشكل symmetrical
+
+409
+00:32:17,450 --> 00:32:24,470
+compound وهذا شيء رائع هنتكلم عنه كمان شوية أو في
+
+410
+00:32:24,470 --> 00:32:29,310
+المحاضرة اللي جاي ان شاء الله بنه الإحساس بالحجوم
+
+411
+00:32:29,310 --> 00:32:34,960
+مهم جدا الجزء الأحمر هذا اللي شايفينه احناهذا قطعة
+
+412
+00:32:34,960 --> 00:32:40,740
+من محيط ال red blood cell دراسته ال red blood cell
+
+413
+00:32:40,740 --> 00:32:45,140
+جداش حجمها؟ سبعة و نص مايكرون سبعة و نص مايكرون
+
+414
+00:32:45,140 --> 00:32:51,300
+القطر تبعها هذه السفينة الفضاء العجيبة هذي شريشا
+
+415
+00:32:51,300 --> 00:33:00,740
+كولاي جداش حجمها؟تلتلاف طول ب ألف قطر، الألف اللي
+
+416
+00:33:00,740 --> 00:33:03,280
+قلنالك هو واحد ايش؟ مايكرون، اللي هو ال 1000
+
+417
+00:33:03,280 --> 00:33:08,040
+نانومتر واحد مايكرون، تطلعولي على الفيروسات، أضخم
+
+418
+00:33:08,040 --> 00:33:12,200
+فيروس على الإطلاق اسمه Ebola virus، في الأخبار
+
+419
+00:33:12,200 --> 00:33:17,300
+أكيد تسمعويلي منهافيروس Ebola من أخطر الفيروسات
+
+420
+00:33:17,300 --> 00:33:23,140
+على كوكب الأرض وهو مولود في أفريقيا والإنسان الذي
+
+421
+00:33:23,140 --> 00:33:27,060
+يوصي بيه يمكن نسبة الوفيات تصل إلى تسعين بالمائة
+
+422
+00:33:27,060 --> 00:33:32,720
+تسعين بالمائة فالنسبة القتل عنده عالي جدا ومرض
+
+423
+00:33:32,720 --> 00:33:37,760
+خطير جداوأكبر ال virus أو أكبر الفيروسات ومع ذلك
+
+424
+00:33:37,760 --> 00:33:41,440
+لو أخدناها لو لو لنا قدرة أنه نعمل drug and drop
+
+425
+00:33:41,440 --> 00:33:44,840
+كان سحبناها وحطناها في الإشريش الكولاي في في في
+
+426
+00:33:44,840 --> 00:33:48,040
+زاوية من زوايا الإشريش الكولاي ده لا لا لا إشريش
+
+427
+00:33:48,040 --> 00:33:53,860
+ان هو كبير اه نعم مقارنة مع مين؟ مع الفيروسات لكن
+
+428
+00:33:53,860 --> 00:33:57,560
+بالنسبة للإشريش الكولاي صغير صلولي على فيروس الرشح
+
+429
+00:33:57,560 --> 00:34:02,720
+اللي حطي على الماوس أنا هنا شوفينه؟ هذا تلاتين
+
+430
+00:34:02,720 --> 00:34:06,240
+نانومترهذا اللي .. اللي .. اللي كل سنة بيزورنا
+
+431
+00:34:06,240 --> 00:34:10,120
+مرتين تلاتة كل واحد فينا تمام؟ ومش قادرين نتخلص
+
+432
+00:34:10,120 --> 00:34:14,840
+منه تلاتين nanometer فقط فيه فيروسات كبيرة زي ال
+
+433
+00:34:14,840 --> 00:34:18,560
+.. ال variola و ال smallpox اللي هو الجدري و ال ..
+
+434
+00:34:18,560 --> 00:34:21,520
+ال .. الجدري ال .. cowpox اللي بيسموه الجدري
+
+435
+00:34:21,520 --> 00:34:24,900
+الأبقار برضه فيروس من الفيروسات الكبيرة لكن كلهم
+
+436
+00:34:24,900 --> 00:34:29,260
+لو جمعناهم يا جماعة و حاطناهم في ال E.coli .. ال E
+
+437
+00:34:29,260 --> 00:34:34,070
+.coli التساهمة دلالة على أنه الفيروسات صغيرةهذه
+
+438
+00:34:34,070 --> 00:34:39,530
+اللوحة أرجو أنها تكون أعطتكم إحساس بالحجوم بتاعة
+
+439
+00:34:39,530 --> 00:34:42,770
+ال .. كل من Red blood cell اللي أنتوا بتشوفوها في
+
+440
+00:34:42,770 --> 00:34:47,350
+ال blood film كرة صغيرة صح؟ و البكتيريا بتشوفوها
+
+441
+00:34:47,350 --> 00:34:53,290
+شحتة صغيرة فيستحيل نقدر نشوف الفيروسات under the
+
+442
+00:34:53,290 --> 00:34:57,230
+ordinary microscope بدنا electron microscope عشان
+
+443
+00:34:57,230 --> 00:34:59,210
+نقدر نشوف هذه المخلوقة
+
+444
+00:35:01,480 --> 00:35:05,760
+أنا ذكرت في التركيب قولت إنه فيه هنا ال virus
+
+445
+00:35:05,760 --> 00:35:11,400
+بتكون من شغلتين بتكون من capsid و بتكون من مادة
+
+446
+00:35:11,400 --> 00:35:15,640
+وراتية وسميناهم nuclear capsid أنا مش قولت monomer
+
+447
+00:35:15,640 --> 00:35:20,360
+ال monomer عشان انه بيكون capsid سموه capsomer إذن
+
+448
+00:35:20,360 --> 00:35:25,260
+هو capsomer بيكون capsid فهمتوش ال capsomer هو
+
+449
+00:35:25,260 --> 00:35:30,100
+monomer واحدة بناء ل ال capsidكل هذا اللي سميناه
+
+450
+00:35:30,100 --> 00:35:34,060
+مع بعض وقلنا نوكليو كابسيت الـ nuclear capsule
+
+451
+00:35:34,060 --> 00:35:40,700
+طبعا في تراكيب أخرى إضافية هنترقلها لما اتكلم عن
+
+452
+00:35:40,700 --> 00:35:46,280
+اللي هو التراكيب الأخرى في الفيروس هذا كمان بعطينا
+
+453
+00:35:46,280 --> 00:35:51,120
+إيحاء بأشكال الفيروسات المختلفة طلعوا ليه على هذا
+
+454
+00:35:53,540 --> 00:35:58,540
+عشان عامة زي في فاكهة في جنوب الشرق أسيا اسمها
+
+455
+00:35:58,540 --> 00:36:02,120
+jackfruit تدوروا عليها في الفيلم هتلاقوها نفس
+
+456
+00:36:02,120 --> 00:36:08,020
+الشكل هذا jackfruit تمام؟ هذا شكل منتظم تماما و
+
+457
+00:36:08,020 --> 00:36:13,560
+بيسموه أشروني .. أشروني يعني عشرين أشروني الوجوه
+
+458
+00:36:13,560 --> 00:36:20,050
+او icosa-hedral و icosa حيمرمع هتجلجوشecosahedral
+
+459
+00:36:20,050 --> 00:36:24,830
+symmetry يعني لو اللي نطلعنا هو شكله زي الكرة لكن
+
+460
+00:36:24,830 --> 00:36:29,510
+الكرة مكونة من عشرين مثلث عشرين مثلث سموها
+
+461
+00:36:29,510 --> 00:36:36,790
+ecosahedral هذا حلقي spiral و عامل زي العكاز اللي
+
+462
+00:36:36,790 --> 00:36:38,390
+هو ال إيبول اللي شفناها قبل شوية اللي عامل زي
+
+463
+00:36:38,390 --> 00:36:46,570
+الدودة إذا فينا شكلين رئيسيين helical إيش يعني
+
+464
+00:36:46,570 --> 00:36:51,540
+helical؟الحلزون اللولوي و Ecosahedral اللي يقول
+
+465
+00:36:51,540 --> 00:36:59,600
+عنه أشروني الوجوه قد نجد بعض الفيروسات تختلف تمتلك
+
+466
+00:36:59,600 --> 00:37:05,160
+شغلتين مع بعض مثلا وين
+
+467
+00:37:05,160 --> 00:37:08,900
+ال bacterium phage كيفين ال bacterium phage اللي
+
+468
+00:37:08,900 --> 00:37:15,850
+هنا الرأس تبعه Ecosahedralلكن ال cooler في الوزن
+
+469
+00:37:15,850 --> 00:37:21,410
+هذا الفيروس helical وهذا بيسموه complex إذا ماكانش
+
+470
+00:37:21,410 --> 00:37:26,350
+icosahedral أو helical مش بيسميه complex complex
+
+471
+00:37:26,350 --> 00:37:29,890
+يعني معقد غالبا بيكون ماخد شكل غير عن الشكليين
+
+472
+00:37:29,890 --> 00:37:34,630
+التانية اللي احنا شوفناها ألخص إيش استفادنا من
+
+473
+00:37:34,630 --> 00:37:40,010
+المحاضرة هذه عرفنا إيش فيروسات كينات حية و لا مش
+
+474
+00:37:40,010 --> 00:37:46,400
+كينات حيةلأ احنا بدنا نفتي في فتوة لو لا مارسنا
+
+475
+00:37:46,400 --> 00:37:51,100
+فتوة مافتوش فيها لحتى لو بمختلفين لاتنتلك من صفات
+
+476
+00:37:51,100 --> 00:37:55,020
+الحياة إلا قدرتها على التكاثر ومشروطة
+
+477
+00:37:55,020 --> 00:38:00,280
+intracellular ولا تنتلك DNA وRNA واحد من التانية
+
+478
+00:38:00,280 --> 00:38:05,720
+يا إما DNA يا إما RNA المكونات تبعتها بسيطة تكاثر
+
+479
+00:38:05,720 --> 00:38:11,990
+تبعها غريب يختلف عن تكاثر المخلوقات الأخرىالحجوة
+
+480
+00:38:11,990 --> 00:38:18,070
+تبعها من 20 إلى 300 نانو متر ورأينا كيف المقارنة
+
+481
+00:38:18,070 --> 00:38:21,250
+بينها وبين الاشتشاكولاي وما بين الورد بلود
+
+482
+00:38:21,250 --> 00:38:26,030
+سيلفشوفنا أشكال مختلفة لكن صنفنا الأشكال لتلاتة
+
+483
+00:38:26,030 --> 00:38:30,270
+الـ Causohedral, Helical و Complex هاي التلات
+
+484
+00:38:30,270 --> 00:38:37,100
+أشياء اللي احنا عرفناها لحد الآن طيبناخد جزء متعلق
+
+485
+00:38:37,100 --> 00:38:41,740
+بالمادة الوراثية لأن هذا أساسي في تصنيف الفيروسات
+
+486
+00:38:41,740 --> 00:38:44,280
+اللي معاها المادة الوراثية
+
+487
+00:38:47,000 --> 00:38:52,720
+مكوّنة للبيروسات إما DNA وإما RNA، الآن هذا أمر
+
+488
+00:38:52,720 --> 00:38:55,520
+سهل أن نقوله، صح هذا لأ؟ كتير سهل، إما DNA ولا
+
+489
+00:38:55,520 --> 00:38:59,620
+RNA، الآن النقطة التانية إنه Single-Stranded أو
+
+490
+00:38:59,620 --> 00:39:04,080
+Double-Stranded، أيضًا لا يورد في أي مخلوقات أخرى
+
+491
+00:39:04,080 --> 00:39:08,100
+أن يكون المادة اللي هو الأن Single-Strandedبس في
+
+492
+00:39:08,100 --> 00:39:11,740
+الفيروسات في single-stranded DNA و في single
+
+493
+00:39:11,740 --> 00:39:17,200
+-stranded RNA تخيلوا فإذا التصنيف بطل DNA و RNA بس
+
+494
+00:39:17,200 --> 00:39:22,800
+DNA single-stranded double-stranded RNA double
+
+495
+00:39:22,800 --> 00:39:31,540
+-stranded و single-stranded في كمان شغل تاني الشغل
+
+496
+00:39:31,540 --> 00:39:37,260
+التاني ان ال RNA ال RNA قد يكون whole RNAأو
+
+497
+00:39:37,260 --> 00:39:42,240
+segmented RNA، إيش يعني segmented؟ قطة ال
+
+498
+00:39:42,240 --> 00:39:45,620
+influenza virus على سبيل المثال فيها eight
+
+499
+00:39:45,620 --> 00:39:49,580
+segments المادة الوراثية تبعتها eight segments،
+
+500
+00:39:49,580 --> 00:39:53,500
+ثمن قطع عشان هي كمان لما بيجي فيروس و فيروس و
+
+501
+00:39:53,500 --> 00:39:56,880
+بيدخلوا داخل خلية، تمام؟ من نوعين مختلفين
+
+502
+00:39:56,880 --> 00:40:01,140
+الفيروسات، من صنفين مختلفينالمادة الوراثية قد
+
+503
+00:40:01,140 --> 00:40:05,940
+تختلط وتروح قطعة من هذا ال virus لمن؟ ل virus آخر،
+
+504
+00:40:05,940 --> 00:40:10,580
+هذا ال virus الآخر بيمتلك الآن صفات جديدة، هذه
+
+505
+00:40:10,580 --> 00:40:17,150
+الصفات الجديدةمنها أنتجينات فلابدوا لأن على
+
+506
+00:40:17,150 --> 00:40:24,070
+أجسامنا تمام هذه الفيروسات كإنها فيروسات جديدة
+
+507
+00:40:24,070 --> 00:40:28,990
+جسمنا ما بتعرف عليها إنها أصابع تساجقك وبالتالي
+
+508
+00:40:28,990 --> 00:40:34,210
+تحدث مرض لدينا هذا واحد، اتنين قد تمتلك بعض عوامل
+
+509
+00:40:34,210 --> 00:40:39,830
+الشراسة الجديدة تسمعوا بإنفلوانزا الطيور؟القلوانزة
+
+510
+00:40:39,830 --> 00:40:46,090
+الطيورة بنات نسبة القتل فيها وصلت ل 65% انتشارها
+
+511
+00:40:46,090 --> 00:40:50,130
+ضعيف، يعني كل اللي أصابتهم لحد الآن حول العالم من
+
+512
+00:40:50,130 --> 00:40:54,650
+سبعة سنوات أو تمان سنوات، لها دلوقت تلت تلف، لكن
+
+513
+00:40:54,650 --> 00:40:59,470
+التلت تلف شخص اللي أصيبه أكتر من نصفهم ماتوايبقى
+
+514
+00:40:59,470 --> 00:41:04,170
+عامة شراسة قوية جدا في هذا الفيروس غير موجود فيه
+
+515
+00:41:04,170 --> 00:41:07,690
+نحن بنوصب بالإنفلوانزا العادية باستمرار و دلوقت ..
+
+516
+00:41:07,690 --> 00:41:08,890
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+517
+00:41:08,890 --> 00:41:11,770
+.. او .. او .. او .. او .. او .. او .. او .. او ..
+
+518
+00:41:11,770 --> 00:41:11,770
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+519
+00:41:11,770 --> 00:41:11,770
+.. او .. او .. او .. او .. او .. او .. او .. او ..
+
+520
+00:41:11,770 --> 00:41:12,210
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+521
+00:41:12,210 --> 00:41:12,210
+.. او .. او .. او .. او .. او .. او .. او .. او ..
+
+522
+00:41:12,210 --> 00:41:16,410
+او .. او .. او ..
+
+523
+00:41:16,410 --> 00:41:20,650
+او ..
+
+524
+00:41:30,110 --> 00:41:34,830
+غالبا الذين يموتون من ال influence هم من كبار السن
+
+525
+00:41:34,830 --> 00:41:39,470
+كلمة كبار السن غالبا مثلا في دولة زي اليابان
+
+526
+00:41:39,470 --> 00:41:48,070
+المتوسط ال life expectancy صار فوق السبعين صار فوق
+
+527
+00:41:48,070 --> 00:41:55,410
+السبعين فبنلاقي نسبة كبيرة من الناسفي هذه الفئة،
+
+528
+00:41:55,410 --> 00:42:00,590
+الفئة مين؟ ال very old age وبالتالي هم هدول الناس
+
+529
+00:42:00,590 --> 00:42:03,990
+اللي دي أكتر ناس ممكن يصابوا بيه أو يموتوا من
+
+530
+00:42:03,990 --> 00:42:09,270
+أمراض مثل اللي هو ال influenza، لكن بشكل عامالمادة
+
+531
+00:42:09,270 --> 00:42:15,410
+الوراثية المجزقة تسهل عملية تبادل القطع وبالتالي
+
+532
+00:42:15,410 --> 00:42:19,970
+في أنحاء اسمها Antigenic Variation Antigenic
+
+533
+00:42:19,970 --> 00:42:23,670
+Variation يعني أيه؟ التغير الجيني من سلالة إلى
+
+534
+00:42:23,670 --> 00:42:30,150
+سلالة أخرى وهذا يعطي أفضلية للفيروس في أنه يحدث
+
+535
+00:42:30,150 --> 00:42:33,930
+دائمًا اللي هو العمل دي كمان نقطة كتير مهمة
+
+536
+00:42:34,570 --> 00:42:40,630
+الفيروسات تنتلق نسخة واحدة من المادة الوراثية داخل
+
+537
+00:42:40,630 --> 00:42:45,630
+النوكليوكابسي نسخة واحدة زي الخلال الجنسية عند
+
+538
+00:42:45,630 --> 00:42:50,930
+الإنسان أكم .. أكم كرموزومي احنا؟ 46 مظبوط، لكن
+
+539
+00:42:50,930 --> 00:42:59,470
+البوايضة؟ 23، ال sperm؟ 23 فالفيروسات تنتلق نسخة
+
+540
+00:42:59,470 --> 00:43:01,870
+واحدة، ايش بنسمي النسخة الواحدة احنا في الوراثة؟
+
+541
+00:43:03,510 --> 00:43:07,450
+لما يكونوا تنتهيوا يسميها deployed يا هل تلاقي فيه
+
+542
+00:43:07,450 --> 00:43:11,350
+فيروسات عندها deployed نعم فيه فيروسات عندها
+
+543
+00:43:11,350 --> 00:43:16,890
+deployed لكن استثناء يعني فيروس واحدة اللي بنعرفه
+
+544
+00:43:16,890 --> 00:43:22,670
+اللي هو ال HIV الفيروس ال AIDS فيه نسختين من
+
+545
+00:43:22,670 --> 00:43:24,530
+المادة الوراقية
+
+546
+00:43:28,940 --> 00:43:31,240
+طيب، اللخص لأن المادة الوراثية بالنسبة لي كتير
+
+547
+00:43:31,240 --> 00:43:38,240
+مهمة في ال .. في ال .. في الفيروسات عندي الفيروس
+
+548
+00:43:38,240 --> 00:43:45,560
+يختلف عن الخلايا بإنه يحتوي يا إما DNA يا إما RNA
+
+549
+00:43:45,560 --> 00:43:49,780
+يعني ال DNA و ال RNA بطل DNA أو RNA عادي يا إما
+
+550
+00:43:49,780 --> 00:43:53,340
+double-stranded يا إما single-stranded و single
+
+551
+00:43:53,340 --> 00:43:58,920
+-stranded يا إما whole يا إما segmentedو مرة أخرى
+
+552
+00:43:58,920 --> 00:44:03,540
+الجينوم ككل ممكن يكون haploid و ممكن يكون diploid
+
+553
+00:44:03,540 --> 00:44:07,100
+و المرة الجاية ان شاء الله بنكمل في نفس السياق
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE.srt
new file mode 100644
index 0000000000000000000000000000000000000000..72edfcb68f2a9cff5bab7f6200e14164bf552d32
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE.srt
@@ -0,0 +1,1994 @@
+1
+00:00:21,160 --> 00:00:23,480
+طيب بسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:23,480 --> 00:00:28,640
+اليوم احنا نتكلم عن فيروس الـ aids ويمكن الكل بيعرف 
+
+3
+00:00:28,640 --> 00:00:33,640
+أنه قبل ثلاثة أيام من هذا اليوم اللي هو الأول من
+
+4
+00:00:33,640 --> 00:00:37,580
+ديسمبر هو اليوم العالمي للـ aids كل عام وأنتم بخير
+
+5
+00:00:38,710 --> 00:00:43,030
+طبعا اليوم العالمي للـ aids أُقر من منظمة الصحة
+
+6
+00:00:43,030 --> 00:00:47,330
+العالمية لتوحيد الجهود العالمية المبذولة لمكافحة
+
+7
+00:00:47,330 --> 00:00:52,090
+هذا المرض الخطير والذي أثر على أو دخل كل دول
+
+8
+00:00:52,090 --> 00:00:54,350
+العالم تقريبا يعني لا ولا دولة في العالم لا ولا
+
+9
+00:00:54,350 --> 00:00:58,250
+دولة فيها مرض الـ aids لكن بنسبة متفاوتة نسبة
+
+10
+00:00:58,250 --> 00:01:01,710
+الوفيات الناجمة عن هذا المرض عالية جدا، الإصابات
+
+11
+00:01:01,710 --> 00:01:05,830
+السنوية عن هذا المرض ما زالت مرتفعة جدا، نحن في
+
+12
+00:01:05,830 --> 00:01:12,850
+الوطن العربي يمكن الأقل نسبًا عالميًا، لكن الأعلى
+
+13
+00:01:12,850 --> 00:01:17,470
+وباقية، بمعنى إنه قاعدين في ارتفاع وأنت عارفين لما 
+
+14
+00:01:17,470 --> 00:01:21,070
+يصير عشرة ويصير عشرين، ايش يعني عشرة وعشرين؟ ضعف
+
+15
+00:01:21,070 --> 00:01:26,400
+العشرين هي ضعف العشرة، صحيح الـ 20 رقم ضئيل جدا
+
+16
+00:01:26,400 --> 00:01:30,780
+بالمقارنة مع الدول الأخرى، لكن التضاعف اللي حصل هو
+
+17
+00:01:30,780 --> 00:01:33,540
+hundred percent، مائة بالمائة، وبالتالي أنا عندي
+
+18
+00:01:33,540 --> 00:01:36,640
+ارتفاع مائة بالمائة في بعض الدول العربية، وبالتالي
+
+19
+00:01:36,640 --> 00:01:43,070
+في خشية من تفشي أيضًا هذا الوباء، قبل ما ندخل في مرض
+
+20
+00:01:43,070 --> 00:01:47,110
+الاسم نتعرف على عائلة اللي بتشمل هذا الفيروس وهي
+
+21
+00:01:47,110 --> 00:01:51,230
+عائلة الـ retro viruses أو retro virida تنقسم إلى
+
+22
+00:01:51,230 --> 00:01:57,390
+three sub families الأولى بنسميها عفواً ما دخلناش
+
+23
+00:01:57,390 --> 00:02:01,910
+على العائلات، هاي العائلات الـ oncovirو الـ Lenti
+
+24
+00:02:01,910 --> 00:02:06,790
+Verne و الـ Spuma Verne، هنحاول نميز بين التلاتة
+
+25
+00:02:06,790 --> 00:02:09,990
+طبعا في منهم واحدة بتعرفوها كويس اللي هي الـ Onco
+
+26
+00:02:09,990 --> 00:02:16,110
+Verne، دراستها من الـ HTLV-1 و الـ HTLV-2 وبيشملوا
+
+27
+00:02:16,110 --> 00:02:19,770
+طبعا فينا كمان هنا HTLV-5، الـ AIDS كان اسمه في يوم
+
+28
+00:02:19,770 --> 00:02:28,130
+من الأيام HTLV-3 يعني أحد أسمائه الأول كان HTLV-3
+
+29
+00:02:29,270 --> 00:02:32,630
+وخصائص هذه المجموعة أنها تعمل immortalization
+
+30
+00:02:32,630 --> 00:02:36,230
+وtransformation للـ target cells، وشوفنا أنها بالفعل
+
+31
+00:02:36,230 --> 00:02:41,450
+تعمل lymphoma و cancer، الـ Lentivirne اللي بينتمي
+
+32
+00:02:41,450 --> 00:02:47,810
+إليها الـ HIV 1 و الـ HIV 2، لها علاقة بعائلة بتسبب
+
+33
+00:02:47,810 --> 00:02:51,510
+شغلتين رئيسيتين immunodeficiencies و immunological
+
+34
+00:02:51,510 --> 00:02:54,730
+disorders، يعني أشياء متعلقة بالأعصاب وأشياء
+
+35
+00:02:54,730 --> 00:03:00,920
+متعلقة بضعف أو انخفاض جهاز المناعة، الأخير ليس له
+
+36
+00:03:00,920 --> 00:03:06,120
+ارتباط بالأمراض اسمها spuma viruses أو human
+
+37
+00:03:06,120 --> 00:03:11,960
+phobia virus، وكلمة phom معناها رغبة، وسميها كده
+
+38
+00:03:11,960 --> 00:03:15,880
+الفيروس لأنه لما نمو على الـ cell culture عندنا الـ
+
+39
+00:03:15,880 --> 00:03:18,900
+bubbles، و الـ bubbles عاملة زي ايه؟ زي الـ phom فسموه
+
+40
+00:03:18,900 --> 00:03:21,900
+human phobia virus، و it is not associated with any
+
+41
+00:03:21,900 --> 00:03:26,710
+of the human diseases، إذن ثلاثة عائلات مختلفة،
+
+42
+00:03:26,710 --> 00:03:31,850
+أنكو، فيرني، لنتي فيرني، سبيوما فيرني، فيروسنا
+
+43
+00:03:31,850 --> 00:03:37,030
+بيتم لأي واحدة منهم، للثاني أن أنت فيران نرجع نطلع
+
+44
+00:03:37,030 --> 00:03:40,730
+على العائلة ككل، ايش الـ characteristics العامة لهذه
+
+45
+00:03:40,730 --> 00:03:44,650
+العائلة؟ رقم واحد أنه معروف عن عائلة الـ
+
+46
+00:03:44,650 --> 00:03:47,050
+retroviruses أنها associated with ايه؟ with
+
+47
+00:03:47,050 --> 00:03:51,890
+tumors, leukemias و immunodeficiencies، خرجت عن هيك
+
+48
+00:03:51,890 --> 00:03:54,630
+هاي الأمراض اللي بتاعتهم ياما immunodeficiency
+
+49
+00:03:54,630 --> 00:03:59,620
+ياما الـ leukemias أو الـ tumors، كمان شغل المهمة
+
+50
+00:03:59,620 --> 00:04:03,640
+unique to this family اللي هو الـ double genome
+
+51
+00:04:03,640 --> 00:04:07,740
+عندهم نسختان من الـ genome سميناهم الـ diploid اللي
+
+52
+00:04:07,740 --> 00:04:11,480
+وجود عنه بوستفسترانديد RNA، طبعا احنا عارفين أن
+
+53
+00:04:11,480 --> 00:04:15,020
+البوستفسترانديد RNA في معظم الفيروس اللي درسناها
+
+54
+00:04:15,020 --> 00:04:20,740
+ما يحتاجش RNA polymerase، مع بيستغل مين؟ بيستغل الـ
+
+55
+00:04:20,740 --> 00:04:24,120
+RNA polymerase اللي موجود في الخلية لكن هذا
+
+56
+00:04:24,120 --> 00:04:29,010
+الفيروس كان يجب من مرحلة التكاثر عنده أنه يتحول من
+
+57
+00:04:29,010 --> 00:04:34,650
+RNA إلى DNA، ما في خلايانا احنا أي مرحلة بتحول الـ
+
+58
+00:04:34,650 --> 00:04:39,150
+RNA إلى DNA، احنا بتحول الـ DNA إلى RNA، اللي هو الـ
+
+59
+00:04:39,150 --> 00:04:43,710
+flow of information DNA RNA بعدين protein، هنا في
+
+60
+00:04:43,710 --> 00:04:48,230
+خطوة عكسية، والخطوة العكسية هذه عملها الفيروس حتى
+
+61
+00:04:48,230 --> 00:04:51,270
+يقوم بـ integration لذاته لأنه ما ينفعش تعمل
+
+62
+00:04:51,270 --> 00:04:56,110
+integration لـ RNA في DNA، فاتحول لـ DNA ثم عمل
+
+63
+00:04:56,110 --> 00:05:00,190
+integration في الـ host genome، إذن genome consist
+
+64
+00:05:00,190 --> 00:05:03,790
+of two copies، الانزيم الانزيم الانزيم الانزيم
+
+65
+00:05:03,790 --> 00:05:04,170
+الانزيم الانزيم الانزيم الانزيم الانزيم الانزيم
+
+66
+00:05:04,170 --> 00:05:06,890
+الانزيم الانزيم الانزيم الانزيم الانزيم الانزيم
+
+67
+00:05:06,890 --> 00:05:12,530
+الانزيم الانزيم الانزيم الانزيم الانزيم الانزيم
+
+68
+00:05:12,530 --> 00:05:19,690
+الانزيم الانزيم الانزيم الانزيم الانزيم
+
+69
+00:05:20,830 --> 00:05:25,610
+واحد أنهم associated with tumors, leukemias and
+
+70
+00:05:25,610 --> 00:05:29,610
+immunodeficiencies، رقم اثنين double genome أو
+
+71
+00:05:29,610 --> 00:05:33,310
+diploid، رقم ثلاثة لديهم reverse transcription
+
+72
+00:05:33,310 --> 00:05:37,810
+process، تعالوا
+
+73
+00:05:37,810 --> 00:05:40,590
+ناخذ بعض المعلومات العامة عن الفيروس، هنعرف كده
+
+74
+00:05:40,590 --> 00:05:46,620
+أهمية هذا الفيروس و ليش العالم عمله يوم عالمي، HIV أو
+
+75
+00:05:46,620 --> 00:05:52,200
+human immunodeficiency virus هو بالعربي مرض أو
+
+76
+00:05:52,200 --> 00:05:55,920
+فيروس عواز المناعة أو نقص المناعة، يعني الإسمين
+
+77
+00:05:55,920 --> 00:06:01,780
+موجودين بشهرة كبيرة، عواز المناعة أو نقص المناعة، Has
+
+78
+00:06:01,780 --> 00:06:04,800
+now spread to every country in the world and has
+
+79
+00:06:04,800 --> 00:06:07,860
+infected over 40 million people worldwide، هذا
+
+80
+00:06:07,860 --> 00:06:12,200
+الكلام في 2009، الآن احنا في 2017، آخر تقرير تتكلم
+
+81
+00:06:12,200 --> 00:06:19,980
+عن 70 مليون إنسان أصيبوا بهذا الفيروس، حوالي 5
+
+82
+00:06:19,980 --> 00:06:24,240
+مليون إنسان يصابوا سنويًا حول العالم بهذا
+
+83
+00:06:24,240 --> 00:06:31,580
+الفيروس، حوالي 3 مليون بيموتوا من هذا الفيروس، يبقى
+
+84
+00:06:31,580 --> 00:06:37,940
+سنويًا كل سنة بيموت ثلاثة مليون وبيصاب خمسة مليون
+
+85
+00:06:37,940 --> 00:06:42,550
+إشعار، في حدود العام 2000 الإحصائي كانت التراكمية
+
+86
+00:06:42,550 --> 00:06:47,190
+لل وفيات من الـ aids كانت حوالي 22 مليون، عارفين
+
+87
+00:06:47,190 --> 00:06:50,890
+متى بدأ الـ aids؟ احنا بنعرف هنا من الـ 84 و 85، يعني
+
+88
+00:06:50,890 --> 00:06:55,790
+ما بنعرفوش من زمان، يعني من الـ 85 لـ 2000 كده 15 سنة
+
+89
+00:06:55,790 --> 00:07:01,670
+15 سنة، إذا في 15 سنة قتل 22 مليون إنسان، مرض خطير و
+
+90
+00:07:01,670 --> 00:07:07,310
+فيروس خطير، لذلك يعني نقدر الجهود العالمية اللي
+
+91
+00:07:07,310 --> 00:07:13,290
+مبذولة لمكافحة هذا المعنى، The scourge of HIV كلمة
+
+92
+00:07:13,290 --> 00:07:21,160
+scourge يعني البلاء، البلاء اللي يسمى HIV كان بشكل
+
+93
+00:07:21,160 --> 00:07:26,160
+خاص مدمرا في sub-saharan Africa، في أفريقيا يعني في
+
+94
+00:07:26,160 --> 00:07:30,760
+قرى قد يصل نصف العدد من السكان مصابين بمرض الـ aids
+
+95
+00:07:30,760 --> 00:07:36,040
+وهذا رقم ضخم جدا، يعني أعلى من أي وبائية في أوروبا
+
+96
+00:07:36,040 --> 00:07:40,510
+وفي الولايات المتحدة، كمان في نقطة كتير مهمة أن نسبة
+
+97
+00:07:40,510 --> 00:07:44,110
+النساء البالغات اللي واتي أصابنا بالـ aids في
+
+98
+00:07:44,110 --> 00:07:47,610
+ازدياد، طبعا كانت النسبة الأعلى دائمًا في صالح .. مش
+
+99
+00:07:47,610 --> 00:07:51,410
+في صالح، ضد الرجال، بمعنى أن الرجال هو الأكثر إصابة
+
+100
+00:07:51,410 --> 00:07:56,450
+لسببين، أن هو أصلاً يعني الـ aids أول ما اكتشف اكتشف
+
+101
+00:07:56,450 --> 00:08:00,770
+في الرجال المثليين، الـ homosexual، المنحرفين 
+
+102
+00:08:03,390 --> 00:08:06,810
+والفئة الثانية اللي هم بتوع المخدرات اللي هم اللي
+
+103
+00:08:06,810 --> 00:08:10,450
+بياخدوا IV drugs، فالرجال أكثر أيضًا عرضة في هذا
+
+104
+00:08:10,450 --> 00:08:14,870
+الجانب، لكن اليوم فيه زيادة في نسبة النساء المصابات
+
+105
+00:08:14,870 --> 00:08:20,990
+بهذا الفيروس، سمي المرض كما ذكرت human T
+
+106
+00:08:20,990 --> 00:08:26,290
+lymphotropic virus type 3 أو HTLV 3، وسمي أيضًا
+
+107
+00:08:26,290 --> 00:08:29,470
+lymphadenopathy associated virus، ليش سمي بهذا
+
+108
+00:08:29,470 --> 00:08:34,370
+الاسم؟ لأن المريض الـ aids قلنا لكم بيصير جثة متحركة
+
+109
+00:08:34,370 --> 00:08:39,180
+يصاب بأعراض كثيرة من ضمن الأعراض الـ lymph node ما
+
+110
+00:08:39,180 --> 00:08:41,600
+أنتم عارفين هي الـ check point، فلو ما يكون فيش
+
+111
+00:08:41,600 --> 00:08:45,560
+مناعة الـ check point بتفشل في مكافحة الأمراض، فالـ
+
+112
+00:08:45,560 --> 00:08:49,260
+lymph node بيصير نفسها inflamed زي اللوز بس في كل
+
+113
+00:08:49,260 --> 00:08:55,100
+الجسم، generalized lymphoadenopathy، فبيصير المرضى الـ
+
+114
+00:08:55,100 --> 00:08:58,500
+aids دائمًا عندهم المناطق اللي فيها lymph node
+
+115
+00:08:58,500 --> 00:09:02,840
+مؤلمة، فبالتالي lymphadenopathy، فسموا الفيروس
+
+116
+00:09:02,840 --> 00:09:06,480
+lymphadenopathy associated virus، وبعدين كمان سموه
+
+117
+00:09:06,480 --> 00:09:13,320
+اسم ثاني aids related virus ARV، وبعدين استقرينا على
+
+118
+00:09:13,320 --> 00:09:17,140
+اسم الأخير الـ HIV أو الـ human immunodeficiency
+
+119
+00:09:17,140 --> 00:09:21,270
+virus، واللي هي one immunodeficiency virus بيجيب
+
+120
+00:09:21,270 --> 00:09:28,830
+ينقسم برضه إلى two genesis HIV1 وHIV2، وكلاهما
+
+121
+00:09:28,830 --> 00:09:32,630
+يسبب indistinguishable AIDS، بمعنى أنه لا نستطيع
+
+122
+00:09:32,630 --> 00:09:36,310
+نتميز أن الـ AIDS هذا اللي بيسببه رقم واحد أو رقم
+
+123
+00:09:36,310 --> 00:09:39,930
+اثنين إلا من خلال الفحوصات السيرولوجية، لكن كشكل
+
+124
+00:09:39,930 --> 00:09:45,140
+اثنين بيعملوا نفس المرض اللي هو AIDS، على عكس إخوته
+
+125
+00:09:45,140 --> 00:09:48,580
+من العيلة الـ HTLV اللي كانوا بيعملوا
+
+126
+00:09:48,580 --> 00:09:53,280
+immortalization، هذا بيعمل killing للـinfected 
+
+127
+00:09:53,280 --> 00:09:56,800
+cells، it kills or damages cells of the body
+
+128
+00:09:56,800 --> 00:10:00,400
+immune system. HIV progressively destroys the
+
+129
+00:10:00,400 --> 00:10:03,080
+body's ability to fight infection and certain
+
+130
+00:10:03,080 --> 00:10:06,080
+cancers. لأن نعرف أن الجهاز المناعي هو المسئول عن
+
+131
+00:10:06,080 --> 00:10:10,880
+مكافحة العدوى، واش كمان مكافحة أيضا السرطانات، إذا 
+
+132
+00:10:10,880 --> 00:10:14,700
+مافيش جهاز مناعي يبقى الـinfection غير مكافحة، و
+
+133
+00:10:14,700 --> 00:10:18,360
+أيضا السرطانات غير مكافحة، وبالتالي بيظهر عليه أعراض
+
+134
+00:10:18,360 --> 00:10:29,840
+من هذا أو من تلك الأمراض، الأشخاص
+
+135
+00:10:29,840 --> 00:10:35,950
+المشخصين بـAIDS سوف يطورون عدوى أو انتهاكات مهددة 
+
+136
+00:10:35,950 --> 00:10:40,390
+لحياة الإنسان، مهددة لحياة الإنسان، طالعة من مين؟
+
+137
+00:10:40,390 --> 00:10:46,330
+من فيروس وبكتيريا عادة لا تسبب أذى لمين؟ للـnormal 
+
+138
+00:10:46,330 --> 00:10:50,010
+individuals، يبقى، إيش بنسمي هذه الأنواع من
+
+139
+00:10:50,010 --> 00:10:53,030
+الميكروبات؟ opportunistic pathogen أو
+
+140
+00:10:53,030 --> 00:10:57,960
+opportunistic infection للمرض نفسه، اللوحة اللي
+
+141
+00:10:57,960 --> 00:11:03,880
+أمامنا بتوضح لنا بعض الصفات للـHIV-1 وHIV-2 كلا
+
+142
+00:11:03,880 --> 00:11:07,640
+هما، بينتقل عبر اللي هو الـsexual contact، blood
+
+143
+00:11:07,640 --> 00:11:12,680
+from mother to child، يعني trans-placental أو خلال
+
+144
+00:11:12,680 --> 00:11:17,380
+الولادة أو حتى من الـbreast milk، يعني في الثلاث
+
+145
+00:11:17,380 --> 00:11:21,840
+حالات ممكن ينتقل من الأم إلى، مش hundred percent الـ
+
+146
+00:11:21,840 --> 00:11:26,290
+transmission، قد يتراوح من خمسة عشر بالمائة إلى خمسين
+
+147
+00:11:26,290 --> 00:11:30,250
+بالمائة، بمعنى أنه احتمالات الانتقال من خمسة عشر
+
+148
+00:11:30,250 --> 00:11:34,970
+يعني مش أكيد الانتقال، both can cause
+
+149
+00:11:34,970 --> 00:11:38,010
+indistinguishable AIDS، كمان مرة الـAIDS اللي
+
+150
+00:11:38,010 --> 00:11:43,000
+بيسببوا HIV one و two ما بينفرقوش عن بعض، HIV-1 هو
+
+151
+00:11:43,000 --> 00:11:47,960
+البرومينانت فيروس، عشان الجملة اللي عاجباه لإنه
+
+152
+00:11:47,960 --> 00:11:54,200
+HIV-2 أقل سهولة الترانزميشن، يعني بينتقلش بسهولة
+
+153
+00:11:54,200 --> 00:12:00,760
+هذا معناه، والتاني شمياله بينتقل بسهولة، في نقطة
+
+154
+00:12:00,760 --> 00:12:05,590
+كتير مهمة بالنسبة لـHIV-1 أنه عنده high rate of
+
+155
+00:12:05,590 --> 00:12:09,230
+replication، وبالتالي بيصير عنده mutation بشكل
+
+156
+00:12:09,230 --> 00:12:14,790
+rapid، لذلك بنلاقي منه كتير subtype، يبقى HIV-1 يلو
+
+157
+00:12:14,790 --> 00:12:20,610
+subtypes عديدة، وهذا أحد أسباب عدم قدرتنا على إنتاج
+
+158
+00:12:20,610 --> 00:12:24,910
+vaccine بشكل جيد، وحنشوف كمان شوية في أحد اللوحات
+
+159
+00:12:24,910 --> 00:12:30,570
+الكلام بيدور حول كيف للفيروس أن يخدع جهاز
+
+160
+00:12:30,570 --> 00:12:36,870
+المناعة، فيروس ذكي وعنده قدرات خاصة، بالنسبة للـHIV-1
+
+161
+00:12:36,870 --> 00:12:42,510
+نحن نعرف أن الفترة ما بين دخول الفيروس وبين ظهور
+
+162
+00:12:42,510 --> 00:12:46,330
+الأعراض للـHIV تتراوح، لكن هي في الآخر طويلة، هي
+
+163
+00:12:46,330 --> 00:12:53,190
+فترة طويلة، غالبا بقى بتكون أطول لما يكون المسبب
+
+164
+00:12:53,190 --> 00:12:57,110
+بالـAIDS هو HIV-9، يعني الفترة الـincubation
+
+165
+00:12:57,110 --> 00:13:03,230
+بتكون مالها؟ أطول من HIV-1، الشكل اللي أمامنا هو
+
+166
+00:13:03,230 --> 00:13:07,810
+الشكل الجميل لهذا الفيروس، طبعا على طول ما حدر بنشوف
+
+167
+00:13:07,810 --> 00:13:13,290
+احنا double genome بيعطينا إي حق مين؟ بالـretro
+
+168
+00:13:13,290 --> 00:13:17,890
+virus، وخاصة لما نشوف منه أنه جدتين الحمر هدول
+
+169
+00:13:17,890 --> 00:13:21,890
+اللي ماشي هدول هدول معبرة عن الانزيم اسمه
+
+170
+00:13:21,890 --> 00:13:27,410
+reverse transcriptase، طبعا فينا envelope وفينا الـ
+
+171
+00:13:27,410 --> 00:13:32,010
+matrix وفينا الـcore في هذا الـparticle التوضيحية
+
+172
+00:13:33,690 --> 00:13:38,110
+هنا بدي اتأكد على أن الـGP كلمة GP مانعش الـ
+
+173
+00:13:38,110 --> 00:13:42,610
+glycoprotein، الـspikes اللي موجودة من أهمهم أن اللي
+
+174
+00:13:42,610 --> 00:13:48,750
+هم الـGP120 والـGP41، هدول مش موجودين في مين؟ في الـ
+
+175
+00:13:48,750 --> 00:13:54,070
+HTLV1، كان في مقابلهم أرقام أخرى غير الـGP120 و41
+
+176
+00:13:54,070 --> 00:13:59,030
+طبعا هنشوف كمان شوية كمان مرة هنا الـdouble genome
+
+177
+00:13:59,030 --> 00:14:04,970
+ويقولنا اللي هو الـRNA polymerase، طالع على اللوحة
+
+178
+00:14:04,970 --> 00:14:08,590
+اللي على جانب هاي الـT cell اللي هي CD4 أو الـ
+
+179
+00:14:08,590 --> 00:14:12,890
+Macrophage، بيكون في عليها دمعة CD4 Receptor وفيها
+
+180
+00:14:12,890 --> 00:14:18,290
+اسمها Co-Receptor، Co-Receptor، فالـGP121 برتبط مع
+
+181
+00:14:18,290 --> 00:14:24,750
+اللي هو الـ .. الـ .. الـ .. الـCD4 Receptor والـGP1
+
+182
+00:14:24,750 --> 00:14:29,670
+.. الـGP41 برتبط مع الـCo-Receptor، العام بعد الحالة
+
+183
+00:14:29,670 --> 00:14:33,210
+الـ .. الـ .. الـbinding للـtwo receptors اللي هو الـ
+
+184
+00:14:33,210 --> 00:14:35,510
+receptor الأصلي والـcore receptor بيعمل الـ
+
+185
+00:14:35,510 --> 00:14:39,710
+binding قوي وبيعمل الـtriggering للـendocytosis
+
+186
+00:14:39,710 --> 00:14:43,230
+أنه .. أنه .. أن الخلية تاخد مين؟ تاخد الفيروس إلى
+
+187
+00:14:43,230 --> 00:14:51,590
+داخل أو إلى داخله، بشكل لطيف وخفيف، بنوضح الـlife
+
+188
+00:14:51,590 --> 00:14:55,210
+cycle تبع الـHIV، هاي الـ ايه الـvirus ايه ده ارتبط
+
+189
+00:14:55,210 --> 00:14:59,130
+مع الـCD4 والـCCR5 هو الـco receptor اللي احنا
+
+190
+00:14:59,130 --> 00:15:02,930
+حكينا عنه قبل قليل، صار له internalization بيصير له
+
+191
+00:15:02,930 --> 00:15:06,830
+uncoating، بعد الـuncoating بيصير في عندنا reverse
+
+192
+00:15:06,830 --> 00:15:12,390
+transcription، بتحول الـRNA إلى DNA، بعدين بيصير له
+
+193
+00:15:12,390 --> 00:15:18,310
+transport إلى النواة وهناك في النواة بيصير له
+
+194
+00:15:18,310 --> 00:15:23,090
+integration داخل الفيروس، بعدين بيصير فيه
+
+195
+00:15:23,090 --> 00:15:29,030
+transcription، الـRNA بيطلع خارج النواة عشان يصير
+
+196
+00:15:29,030 --> 00:15:34,540
+له translation، وبعدين بيصير في عملية، طبعا في جزء
+
+197
+00:15:34,540 --> 00:15:38,480
+من الـlife cycle مفقود هنا، هو أنه جزء من الـ من الـ
+
+198
+00:15:38,480 --> 00:15:43,020
+core تبع الـvirus بقعد بيرجع لمين؟ بيرجع للنواة
+
+199
+00:15:43,020 --> 00:15:47,080
+بيصير له maturation وبعدين بطلع إلى الخارج، طبعا
+
+200
+00:15:47,080 --> 00:15:49,940
+الخروج عن طريق اللي وجودنا الـbudding، وفي الـ
+
+201
+00:15:49,940 --> 00:15:52,540
+budding بياخد الـspikes تبعته اللي من ضمنها الـ
+
+202
+00:15:52,540 --> 00:15:55,300
+GP120 والـGP41
+
+203
+00:15:57,590 --> 00:16:02,070
+الـmaturation يُقارنها بالفترة في الـbudding أو
+
+204
+00:16:02,070 --> 00:16:06,030
+حتى بعدما يصبح الفيروس بيصير له الـmaturation
+
+205
+00:16:06,030 --> 00:16:10,110
+احنا 
+
+206
+00:16:10,110 --> 00:16:14,930
+درسنا في الـHTLV فيروسات جونا الـretro viruses
+
+207
+00:16:14,930 --> 00:16:19,350
+بتحتوي على نوعين من الجينات سمناهم structural gene
+
+208
+00:16:20,580 --> 00:16:24,940
+و regulatory genes، وكنا فيه structural genes common
+
+209
+00:16:24,940 --> 00:16:30,300
+to all retroviruses زي الـgag والـpol والـenv، الـgag
+
+210
+00:16:30,300 --> 00:16:35,720
+بتطلعنا بروتينات زي بروتينات 24 و17 و7 اللي هم
+
+211
+00:16:35,720 --> 00:16:39,160
+موجودين في الـnucleocaspid والـp17 اللي موجود في
+
+212
+00:16:39,160 --> 00:16:41,340
+من؟ في الـmatrix، كلكم بتعرفوا شو الـmatrix؟ الـ
+
+213
+00:16:41,340 --> 00:16:44,600
+matrix اللي هو اللي بين الـcapsid وين؟ الـenvelope
+
+214
+00:16:45,630 --> 00:16:49,630
+والـpol هو اللي بتطلعنا الانزيمات الثلاث الشهيرة
+
+215
+00:16:49,630 --> 00:16:52,790
+في الـretrovirus اللي هي الـreverse transcriptase
+
+216
+00:16:52,790 --> 00:16:57,850
+والـprotease والـintegrase، gag pol env، الـenv
+
+217
+00:16:57,850 --> 00:17:03,350
+جاية من كلمة envelope لأنه بتطلعنا مين؟ الـGP120 والـ
+
+218
+00:17:03,350 --> 00:17:07,830
+GP41، هذا اللي واش شفناهم في الـ .. في الـenvelope
+
+219
+00:17:07,830 --> 00:17:11,270
+مظبوط، في النقل هون في الـenvelope، دعنا نطلع على الـ
+
+220
+00:17:11,270 --> 00:17:15,210
+functions، قولنا الـجيب الـ الـp24، p7 يومولودين
+
+221
+00:17:15,210 --> 00:17:19,710
+في الـnuclear capsule، الـp17 موجود في الـmatrix
+
+222
+00:17:19,710 --> 00:17:22,730
+طبعا الـmatrix اللي قولنالك هو عبارة عن support ما
+
+223
+00:17:22,730 --> 00:17:26,730
+بين يعني ما ينفعش يكون في عندي membrane وفي عندي
+
+224
+00:17:26,730 --> 00:17:32,110
+capsid وفراغ بينهم، لازم يكون في matrix يعبي هذا
+
+225
+00:17:32,110 --> 00:17:35,870
+اللي هو الفراغ، الـReverse transcriptase وظيفته
+
+226
+00:17:35,870 --> 00:17:39,590
+عرفناها أن نحول الـRNA إلى الـDNA، لبروتياز
+
+227
+00:17:39,590 --> 00:17:46,310
+فاكرينه؟ لما قلنا الـprecursor polypeptide بيقطع
+
+228
+00:17:46,310 --> 00:17:52,050
+الـintegrase هو المسئول عن عملية الدمج، الـDNA
+
+229
+00:17:52,050 --> 00:17:54,130
+بتاع الفيروس اللي اتكون حديثا بالـReverse
+
+230
+00:17:54,130 --> 00:17:58,730
+transcriptase في our own cellular DNA، الـGP120
+
+231
+00:17:58,730 --> 00:18:01,750
+اللي هو مسؤول عن الـattachment لـCD4 Receptor
+
+232
+00:18:01,750 --> 00:18:05,950
+شوفناها في التكملة قبل قليل أيضا، الـGP41 بيساعد
+
+233
+00:18:05,950 --> 00:18:09,110
+أنه قلنالكوا بارتباطه بالـcore receptor بيساعد في
+
+234
+00:18:09,110 --> 00:18:12,010
+الـfusion مع الـhost cell والترابيسي اللي هو
+
+235
+00:18:12,010 --> 00:18:17,730
+internalization إلى الداخل، هذا يعني البروتينات
+
+236
+00:18:17,730 --> 00:18:22,290
+الستركتورية، طيب نيجي للـregulatory protein برضه
+
+237
+00:18:24,570 --> 00:18:31,590
+في منها شبيه شفناها في وين؟ في الـHTLV مثلا شفنا
+
+238
+00:18:31,590 --> 00:18:37,770
+tat، tax، عفوا، tax وشفنا rev، يعني نفس الأحرف اللي
+
+239
+00:18:37,770 --> 00:18:42,890
+اتغير هنا من الحرف الأخير، هنا tat بدل tax وهنا ref
+
+240
+00:18:42,890 --> 00:18:47,710
+بدل rev، تعالوا نشوف الـtat واتذكروا الـtat هو كان
+
+241
+00:18:47,710 --> 00:18:53,190
+الـجين في الـHTLV one، مين متذكرش كانت وظيفته؟
+
+242
+00:18:56,880 --> 00:19:03,720
+Tax Gene، لأ، اقرأوا الوظيفة الموجودة على الصبورة
+
+243
+00:19:03,720 --> 00:19:06,660
+الآن وشوفوا الشبه بين الاتنين، activation of ..
+
+244
+00:19:06,660 --> 00:19:09,820
+أصلًا اسمه Transactivation لـTranscription
+
+245
+00:19:09,820 --> 00:19:12,960
+Transactivator لـTranscription، هي مع الـtat
+
+246
+00:19:12,960 --> 00:19:20,200
+Transactivation of Transcription، it activates of
+
+247
+00:19:20,200 --> 00:19:24,230
+transcription of viral genes، هداك كان يعمل
+
+248
+00:19:24,230 --> 00:19:28,530
+activation للـtranscription of both viral and
+
+249
+00:19:28,530 --> 00:19:32,930
+cellular gene، وهذا هو السبب لأنه صار لنا cancer في
+
+250
+00:19:32,930 --> 00:19:37,230
+الفيروس التاني الـHTLV أنه عمل activation لكل الـ 
+
+251
+00:19:37,230 --> 00:19:41,390
+transcription وبالتالي كل الجينات صارت لها expression
+
+252
+00:19:41,390 --> 00:19:48,080
+صار في عندي uncontrolled growth، الرف بيساعد على 
+
+253
+00:19:48,080 --> 00:19:51,520
+protein تبعه بيساعد على transport of late mRNA
+
+254
+00:19:51,520 --> 00:19:55,300
+from the nucleus to the cytoplasm، كلكم بتعرفوا
+
+255
+00:19:55,300 --> 00:20:00,160
+أنه الـ mRNA لازم يطلع من النواة إلى الـ cytoplasm
+
+256
+00:20:00,160 --> 00:20:05,500
+عشان يصير له translation، هذا الرف بيساعد في نقل الـ
+
+257
+00:20:05,500 --> 00:20:08,880
+late mRNA، طبعًا عارفين إيش يعني late mRNA؟ في early
+
+258
+00:20:08,880 --> 00:20:15,220
+mRNA، تذكرينه من أول الفصل، early و late، فبالإضافة
+
+259
+00:20:15,220 --> 00:20:17,380
+إلى الجينات اللي ذكرناها من اللي قلنا عنها 
+
+260
+00:20:17,380 --> 00:20:22,720
+regulatory، في حد اسمها accessory genes، وتعطيكم
+
+261
+00:20:22,720 --> 00:20:28,060
+إيه حق كلمة accessory؟ إيه اسمها accessory؟ زيادة،
+
+262
+00:20:28,060 --> 00:20:30,960
+في حد اسمها زيادة؟ في فيروس زيادة؟ في حد اسمها
+
+263
+00:20:30,960 --> 00:20:34,720
+زيادة؟ ما في حد اسمها زيادة، لكن المقصود فيها إنها
+
+264
+00:20:34,720 --> 00:20:38,700
+مش essential أو مش required للـ replication، مش
+
+265
+00:20:38,700 --> 00:20:43,150
+required للـ replication، يعني ممكن نشيلها والفيروس
+
+266
+00:20:43,150 --> 00:20:49,590
+بشكل عام يتكاثر، لكن بشرط ما يكونش فيه مناعة، يتكاثر
+
+267
+00:20:49,590 --> 00:20:53,530
+لو ما يكونش فيه حد ضد الفيروس، يعني ممكن هذا الكلام
+
+268
+00:20:53,530 --> 00:20:58,350
+كويس للـ cell culture، لو جربنا الجينات وحطينا الـ
+
+269
+00:20:58,350 --> 00:21:01,690
+HIV في cell culture، ممكن يتكاثر بسهولة بدون هذه
+
+270
+00:21:01,690 --> 00:21:12,550
+الجينة، نف و VIF و VPR و VPU، هذه الـ accessory genes لها
+
+271
+00:21:12,550 --> 00:21:17,830
+وظائف رائعة جدًا، تعالوا نطلع على أول واحد، نف
+
+272
+00:21:19,110 --> 00:21:23,750
+والجين بينكتب بحروف صغيرة وفي خط مائل، وكله small، الجين والـ
+
+273
+00:21:23,750 --> 00:21:27,710
+protein تبعه بينكتب مش بمائل، وأول حرف ماله 
+
+274
+00:21:27,710 --> 00:21:31,370
+capital، يعني هذا الـ Nef هو الجين، وهذا مش ماله، هذا
+
+275
+00:21:31,370 --> 00:21:35,730
+الـ protein تبع هذا الجين، إذا الـ gene بيكتب بطريقة
+
+276
+00:21:35,730 --> 00:21:39,270
+مائلة، بينما الـ product بتبعته بتكتب بالطريقة هذه،
+
+277
+00:21:39,270 --> 00:21:42,610
+الأول حرف بيكون capital مش زي هنا small.
+
+278
+00:21:46,480 --> 00:21:50,720
+كلكم بتعرفوا إنه الـ cytotoxic T cell والـ natural
+
+279
+00:21:50,720 --> 00:21:55,240
+killer cells بيلفلفوا على جهاز المناعة، بيلفلفوا على
+
+280
+00:21:55,240 --> 00:21:58,900
+الخلايا في الجسم، كل يوم بيطلعوا، كل لحظة بيطلعوا
+
+281
+00:21:58,900 --> 00:22:03,840
+عليها، نورمال، نورمال، نورمال، كيف بيعرف إنه نورمال
+
+282
+00:22:03,840 --> 00:22:07,140
+ولا مش نورمال؟ إما decreased expression أو
+
+283
+00:22:07,140 --> 00:22:12,180
+increased expression، أو فيه عندي new genes مش
+
+284
+00:22:12,180 --> 00:22:15,540
+موجودة أصلاً، يعني أو عفواً، new proteins expressed
+
+285
+00:22:15,540 --> 00:22:19,080
+على الـ surface تبع الخلايا، مش من ضمن اللي هو الـ
+
+286
+00:22:19,080 --> 00:22:23,700
+normal cells، إذا الـ T cell راح على التغير على هذه
+
+287
+00:22:23,700 --> 00:22:29,480
+الخلايا، بتهاجمها وبتقتلها، طب كيف الـ HIV بده يخفي
+
+288
+00:22:29,480 --> 00:22:34,880
+نفسه عن باقي جهاز المناعة من خلال الـ Nef gene؟
+
+289
+00:22:34,880 --> 00:22:41,180
+كيف؟ بيعمل decrease للـ CD4 proteins وdecrease للـ
+
+290
+00:22:41,180 --> 00:22:45,080
+class 1 MHC protein على الـ surface تبع الـ infected
+
+291
+00:22:45,080 --> 00:22:51,150
+cells، هذا الـ decrease هو الأصل يصير increase،
+
+292
+00:22:51,150 --> 00:22:55,410
+الأصل يصير increase، لأن هذه الخلية بشكل عام مصابة بالفيروس،
+
+293
+00:22:55,410 --> 00:23:00,270
+عشان تقنع نفسها لجهاز المناعة، الأصل تزيد من إنتاج
+
+294
+00:23:00,270 --> 00:23:05,870
+مين؟ لـ class I MHC، هنا بيعمل decrease، يبقى معنا
+
+295
+00:23:05,870 --> 00:23:10,150
+الحكي، بيصير الـ Cytotoxic مر عنها وتفكرها normal،
+
+296
+00:23:10,150 --> 00:23:15,900
+مش هتعرف إن فيه جواها خطر، هذا ممكن يؤدي إلى أن الـ
+
+297
+00:23:15,900 --> 00:23:18,980
+... ال ... ال ... الـ Cytotoxic cell اللي جاي تقتل
+
+298
+00:23:18,980 --> 00:23:22,220
+الخلية، إذا ما نجاتش إليها دور إنه يصير فيها
+
+299
+00:23:22,220 --> 00:23:26,460
+activation للـ apoptosis، وهي نفسها اللي تموت، و
+
+300
+00:23:26,460 --> 00:23:31,240
+هذا لقول جين مهم جدًا في الـ viralness أو الـ
+
+301
+00:23:31,240 --> 00:23:35,360
+pathogenesis للـ SIV، إيش دخل الـ SIV؟ احنا مش كدا مع
+
+302
+00:23:35,360 --> 00:23:43,810
+مين؟ عن HIV، إيش الـ SIV هذا؟ اسمه أحد النظريات اللي
+
+303
+00:23:43,810 --> 00:23:49,510
+بتتكلم عن نشوء مرض الـ AIDS، عشان تتعرفوا أن كل شيء
+
+304
+00:23:49,510 --> 00:23:54,790
+في الدنيا هنا يعني موجود فيه اتزان رهيب، الغابات
+
+305
+00:23:54,790 --> 00:23:58,950
+اللي ... اللي موجود فيها القرود والحيوانات الأخرى
+
+306
+00:23:58,950 --> 00:24:02,930
+احنا عشان عملنا كبشر أول ما صار لنا منشار كهرباء و
+
+307
+00:24:02,930 --> 00:24:08,250
+دوات وجرفات، راحنا إيه؟ انجبنا على خشب، وكتير من
+
+308
+00:24:08,250 --> 00:24:13,490
+الغابات تأكلت،الفيروس كان عايش مع القرود هناك مبسوط
+
+309
+00:24:13,490 --> 00:24:17,530
+ومكيف، لأن القرود تبقى معاه مبسوطين، فهو بيتقل
+
+310
+00:24:17,530 --> 00:24:22,490
+بينهم وبيمرض، وفيه اتزان في الموضوع، لأن الشجر خف،
+
+311
+00:24:22,490 --> 00:24:26,950
+القرود مالها خفت، الفيروس الزعلان جالك أنت وين وديته
+
+312
+00:24:26,950 --> 00:24:31,490
+... اه وين وديته ال ... الـ host تبعي، طب هو اللي
+
+313
+00:24:31,490 --> 00:24:35,570
+هوريكوا أنا غير، انتقل لمين؟ للبناء الآدمي، وعلى فكرة
+
+314
+00:24:35,570 --> 00:24:40,470
+كل فترة وفترة بيجينا زي ما قلتوا إيبولا، تقلفيه
+
+315
+00:24:40,470 --> 00:24:44,630
+boundaries، المفروض أن في حدود بيننا وبين الفيروسات
+
+316
+00:24:44,630 --> 00:24:49,730
+الـ animal viruses، كل فترة وفترة بيتعداها أو بيتعدا
+
+317
+00:24:49,730 --> 00:24:53,450
+بعض من هذه الفيروسات، من الحيواني إلى الحادث
+
+318
+00:24:53,450 --> 00:24:59,150
+الآدمي، وهناك نظرية تقول إنه لأن الـ SIV معناها
+
+319
+00:24:59,150 --> 00:25:03,250
+simian immunodeficiency virus، وكلمة simian معناها
+
+320
+00:25:03,250 --> 00:25:07,400
+قرد، قرود، فهذا ال ... الـ H ... يعني AIDS القرود، AIDS
+
+321
+00:25:07,400 --> 00:25:10,620
+القرود، فهناك نظرية بتقول إنه ... إن الـ AIDS أصلاً
+
+322
+00:25:10,620 --> 00:25:15,660
+نشأ من وين؟ نشأ من اللي هو القرود، وأصاب الإنسان، والـ
+
+323
+00:25:15,660 --> 00:25:18,540
+... والنظرية بتقول إنه المرض موجود من سنة ألف
+
+324
+00:25:18,540 --> 00:25:23,620
+وتسعمائة وأربعين، أو أقل من ذلك، لكن لما وصل له واتـ
+
+325
+00:25:23,620 --> 00:25:27,960
+أقلم مع الإنسان، يعني ظهر في الثمانينات، القرن اللي
+
+326
+00:25:27,960 --> 00:25:32,610
+هو المرض، إذا أنا عارف إيش يعنيه؟ SIV، Simian
+
+327
+00:25:32,610 --> 00:25:39,050
+Immunodeficiency Virus، أرجو أن فكرة إنه إذا احنا
+
+328
+00:25:39,050 --> 00:25:43,070
+كبشر بنقوم بأعمال، فيه consequences لهذه الأعمال
+
+329
+00:25:44,040 --> 00:25:47,960
+وأنا ذكرت لكم سابقًا أن بعض الأحيان احنا بنحس حالنا
+
+330
+00:25:47,960 --> 00:25:53,860
+في مشكلة، صح؟ لكن بنكون واقعًا إما خلقنا مشكلة كبيرة
+
+331
+00:25:53,860 --> 00:25:59,800
+وكما قال أحدهم بأن مشاكلنا اليوم هي
+
+332
+00:25:59,800 --> 00:26:05,560
+حلول أو نتائج حلول الأمس، واحنا من قبل نحاول نحل
+
+333
+00:26:05,560 --> 00:26:09,660
+مشاكل ونخلق مشاكل، وهذا الكلام كمان شفناه في
+
+334
+00:26:09,660 --> 00:26:13,480
+موضوع استخدام البشر للـ antibiotic المفرط، أن احنا
+
+335
+00:26:13,480 --> 00:26:16,740
+نعم حلنا مشكلة الأمراض الماضية جزئيًا، لكن خلقنا
+
+336
+00:26:16,740 --> 00:26:21,300
+مشاكل أخرى كثيرة، السكر والضغط وأمراض الشرايين، وإيه 
+
+337
+00:26:21,300 --> 00:26:25,400
+الآخر، فيجب أن ننتبه أن الإنسان لابد أن يعيش in
+
+338
+00:26:25,400 --> 00:26:30,340
+harmony with his environment، لازم يعني بتناغم مع
+
+339
+00:26:30,340 --> 00:26:36,300
+البيئة، ولا يستغل البيئة أقصى استغلال، طيب، هدّ حاضر،
+
+340
+00:26:36,300 --> 00:26:42,220
+اتنين، النف، نيجي للـ VIF، enhance infectivity، enhance
+
+341
+00:26:42,220 --> 00:26:47,160
+infectivity، إيش يعني enhance infectivity؟ بيساعد القدرة على
+
+342
+00:26:47,160 --> 00:26:50,560
+أنه يعمل infection من خلال إيش؟ في إنزيم بينتج عندنا،
+
+343
+00:26:50,560 --> 00:26:54,480
+احنا احنا احنا كـ host، اسمه APOBEC3G،
+
+344
+00:26:57,690 --> 00:27:04,530
+APOBEC3G، هذا الإنزيم يبدو أنه مخصص لإحداث طفرات في
+
+345
+00:27:04,530 --> 00:27:07,710
+الـ retrovirus، يعني الإنزيم اللي احنا فبيعمل طفرات
+
+346
+00:27:07,710 --> 00:27:11,310
+في الـ retrovirus، وكلمة hyper mutation يعني طفرات
+
+347
+00:27:11,310 --> 00:27:15,270
+بشكل إيه؟ بشكل كبير، لدرجة أن الفيروس هيصير من
+
+348
+00:27:15,270 --> 00:27:19,110
+الطفرات هذه غير قادر على أنه يتكاثر، يبقى فيها نحن 
+
+349
+00:27:19,110 --> 00:27:23,410
+دفاع ضد الـ retrovirus، إيش اسمه؟ APOBEC3G،
+
+350
+00:27:25,460 --> 00:27:31,980
+للأسف الـ VIF بيعطل هذا الإنزيم، يعني مفضل فيروس
+
+351
+00:27:31,980 --> 00:27:36,060
+جاية معاه إيه؟ معاه سلاح يعطل السلاح تابعنا اللي
+
+352
+00:27:36,060 --> 00:27:41,000
+هو موجه ضد هذا الفيروس، وصلت الصورة؟ فالـ VIF إيه اللي
+
+353
+00:27:41,000 --> 00:27:45,020
+هو أهمية كبرى؟ بإنه بيمنع الإنزيم اللي بيخرب الـ
+
+354
+00:27:45,020 --> 00:27:50,590
+retrovirus، التالت اللي هو الـ VPR، الـ transport viral
+
+355
+00:27:50,590 --> 00:27:52,890
+core، قلت له الـ core قبل شوية، أنا في ال ... في ال ...
+
+356
+00:27:52,890 --> 00:27:56,010
+في الـ life cycle، فيش ناجس إنه في مرحلة، مرحلة بناخد
+
+357
+00:27:56,010 --> 00:27:59,390
+الـ core تبع ال ... ال ... ال ... الـ virus، بيرجع على
+
+358
+00:27:59,390 --> 00:28:05,430
+مين؟ على إنه فالـ VPR هو اللي بيوصله، إنه الـ VPU
+
+359
+00:28:05,430 --> 00:28:09,950
+بيعمل enhancement لـ viral release من الـ cells،
+
+360
+00:28:09,950 --> 00:28:12,570
+فاكرين؟ شوفوا أنا قبل شوية احنا بيعمل budding زي
+
+361
+00:28:12,570 --> 00:28:17,110
+الـ Neuraminidase في الانفلونزا، مش هو كان مسؤول عن
+
+362
+00:28:17,110 --> 00:28:20,890
+قص الفيروس وإخراجه للخارج؟ فهي لأن الـ VPU هو
+
+363
+00:28:20,890 --> 00:28:25,450
+المسؤول عن أو بيحسن من قدرة الفيروس على الخروج إلى
+
+364
+00:28:25,450 --> 00:28:26,970
+خارج الخلية.
+
+365
+00:28:29,810 --> 00:28:36,310
+So what aids، أصيب الـ CD4 cells، الـ CD4 cells is
+
+366
+00:28:36,310 --> 00:28:39,290
+considered by many as the maestro of the immune
+
+367
+00:28:39,290 --> 00:28:43,910
+system، المعيستر هو اللي بيعمل organization أو
+
+368
+00:28:43,910 --> 00:28:47,350
+orchestration للجهود تبع كل الناس اللي موجودين
+
+369
+00:28:47,350 --> 00:28:52,390
+حواليه، القاعدة الأوركسترية مش موجودة، وبنبدأ
+
+370
+00:28:52,390 --> 00:28:55,990
+المعزوفة تبعتنا، هذا بتطبل، هذا بتخبط، هذا بتعمل
+
+371
+00:28:55,990 --> 00:29:00,600
+هتطلع عنا إشي غالبًا مش هتطلع عنا إشي، الجهاز المناعة
+
+372
+00:29:00,600 --> 00:29:07,580
+بدأ أو بدأ يكون بدون رأس، ما لوش موجه، يعني إذا أردت
+
+373
+00:29:07,580 --> 00:29:12,000
+أن تقتل الأفعى، فضل بالرأس، فيروس الـ AIDS اجى على رأس
+
+374
+00:29:12,000 --> 00:29:15,780
+جهاز المناعة اللي هي الـ CD4، والماكروفاج هو بصير
+
+375
+00:29:15,780 --> 00:29:18,540
+من نوعين من الخلايا اللي هم الـ CD4، تيه البرسيل. 
+
+376
+00:29:18,540 --> 00:29:26,360
+والماكروفاج وهوبالتالي نحن فقدنا يا بنات أهم عنصر
+
+377
+00:29:26,360 --> 00:29:30,220
+أو أهم عناصر جهاز المناعة ولو لا وجود المناعة التي 
+
+378
+00:29:30,220 --> 00:29:32,300
+سميناها innate immune system بتعرفوها الـ innate
+
+379
+00:29:32,300 --> 00:29:37,420
+immune system الجلد، الـ stomach acid،  الـ mucus اللي في 
+
+380
+00:29:37,420 --> 00:29:41,570
+الأذن، الشمع هذه اسمها innate immune system التي لو
+
+381
+00:29:41,570 --> 00:29:45,670
+أنها مش موجودة، بتكون تتخيلوا الإنسان الآن هو جثة 
+
+382
+00:29:45,670 --> 00:29:50,370
+تمشي أو تتحرك على الأرض، كل شيء ممكن يصيبه،
+
+383
+00:29:50,370 --> 00:29:53,090
+pseudomonas aeruginosa اللي هي opportunistic
+
+384
+00:29:53,090 --> 00:29:56,830
+pathogen، candida albicans، حتى الحشرات هتطفل
+
+385
+00:29:56,830 --> 00:30:02,210
+عليه، إذن هو فقد الجهاز المناعة اللي هو الـ
+
+386
+00:30:02,210 --> 00:30:06,060
+adaptive immune system، ضايل عنده  هشامين الـ innate
+
+387
+00:30:06,060 --> 00:30:10,000
+immune system اللي هو يعني زي الجلد و الشعر اللي
+
+388
+00:30:10,000 --> 00:30:13,940
+في الأنف و الـ acid اللي موجود في الـ mind لذلك هو 
+
+389
+00:30:13,940 --> 00:30:16,960
+عرض للإصابة بـ opportunistic infection كثيرة من 
+
+390
+00:30:16,960 --> 00:30:21,120
+ضمنها مجسمينها في اللوحتين هذول اللي معانا lung,
+
+391
+00:30:21,880 --> 00:30:25,780
+mouth, esophagus, intestinal tract طلعوا على الـ
+
+392
+00:30:25,780 --> 00:30:30,980
+lung نيومونيا و tuberculosisلما بنقول aids، بنقول
+
+393
+00:30:30,980 --> 00:30:34,860
+tuberculosis لأن أسهل ناس ينصابوا بالـ
+
+394
+00:30:34,860 --> 00:30:39,000
+tuberculosis هم من مرضى الـ aids و اللي بتسببها 
+
+395
+00:30:39,000 --> 00:30:41,240
+طبعا mycobacterium tuberculosis طبعا الـ
+
+396
+00:30:41,240 --> 00:30:45,840
+pneumonia فيبرازايت أو بالأحرى fungi اسمه
+
+397
+00:30:45,840 --> 00:30:49,480
+نيوموسيستس جيروفيسي أو نيوموسيستس كاريناي
+
+398
+00:30:49,480 --> 00:30:54,980
+نيوموسيستس كاريناي أو جيروفيسي اسم الجديد جيروفيسي
+
+399
+00:30:57,970 --> 00:31:01,350
+مرضى وما راشس مانع فيها أنَّها بتسبب pneumonia عند
+
+400
+00:31:01,350 --> 00:31:05,190
+الأصحاء فقط عند مين؟ عند مرضى الـ aids أو عند دول
+
+401
+00:31:05,190 --> 00:31:10,930
+مناعة المنقفضة تماما الـ Mouth in the thrush اللي هو
+
+402
+00:31:10,930 --> 00:31:14,150
+البيضاء تبع الفم وغالبا بتسببه Candida albicans
+
+403
+00:31:14,150 --> 00:31:19,470
+الخميرة المشهورة و الـ Heri leukoplakia ودرسناها في
+
+404
+00:31:19,470 --> 00:31:23,590
+الـ ابشتين بار فيروس و Ulceration ممكن caused by
+
+405
+00:31:23,590 --> 00:31:27,210
+herpes simplex virus و Histoplasma capsulatum و هي
+
+406
+00:31:27,210 --> 00:31:33,230
+خميرة أيضا تعتبر opportunistic pathogen الإيسوفاجوس
+
+407
+00:31:33,230 --> 00:31:37,870
+عاوز فيه أنه thrush و caused by candida albicans
+
+408
+00:31:37,870 --> 00:31:42,030
+غالبا الـ mouth و الإيسوفاجوس جراب من بعضها فممكن
+
+409
+00:31:42,030 --> 00:31:45,210
+يكون الـ mouth فيه thrush و في نفس الوقت يكون فيه
+
+410
+00:31:45,210 --> 00:31:48,010
+في الإيسوفاجوس thrush caused by the same
+
+411
+00:31:48,010 --> 00:31:51,270
+microorganism اللي هو candida albicans و الـ
+
+412
+00:31:51,270 --> 00:31:53,990
+candida albicans يا بنات في الفطريات أنا بعلم
+
+413
+00:31:53,990 --> 00:31:59,450
+فطريات و طلبت الملستير بقولهم أنَّه أهم عشرة أسباب
+
+414
+00:32:00,980 --> 00:32:07,320
+ليه؟ الأمراض الطفيلية هي Candida Candida Candida و
+
+415
+00:32:07,320 --> 00:32:12,260
+بعد لمن؟ لعند سبعة يعني أول يعني بتجيب جوه سبعين
+
+416
+00:32:12,260 --> 00:32:17,180
+بالمية من الأمراض اللي بتسببها الفطريات مرهونة
+
+417
+00:32:17,180 --> 00:32:20,180
+بمين؟ بالـ Candida الـ .. بقى نسبة تلاتين بالمية
+
+418
+00:32:20,180 --> 00:32:24,800
+للأمراض الفطرية الأخرى طلعنا قبل فترة واجيزة خميرة
+
+419
+00:32:24,800 --> 00:32:28,950
+دا اسمها Candida Oris في الولايات المتحدة وفي بعض
+
+420
+00:32:28,950 --> 00:32:33,110
+الدول الأخرى و resistant لكل الـ antifungal هي برضه
+
+421
+00:32:33,110 --> 00:32:36,090
+الخميرة مش بسيطة في الموضوع الـ antimicrobial
+
+422
+00:32:36,090 --> 00:32:36,690
+resistance
+
+423
+00:32:40,670 --> 00:32:44,490
+دياريا و دياريا can be caused by several
+
+424
+00:32:44,490 --> 00:32:47,390
+microorganisms لكن كلكم بتعرفوا الـ cytomegalovirus اللي هو
+
+425
+00:32:47,390 --> 00:32:50,990
+الشجر اللي عند الأصحى و غير الأصحى بتعمل infection
+
+426
+00:32:50,990 --> 00:32:53,890
+فعادي أنَّه نجيها في مرضى الـ aids هاللي عمره طبيعي
+
+427
+00:32:53,890 --> 00:32:57,890
+لكن اللي مش طبيعي اللي هو الـ CMV أنَّه يعمل دياريا
+
+428
+00:32:58,540 --> 00:33:01,420
+عند المرضى الـ AIDS اللي مش طبيعي أنَّه يجي لـ
+
+429
+00:33:01,420 --> 00:33:06,520
+Cryptococcus أو Cryptosporidium Parvum و هي
+
+430
+00:33:06,520 --> 00:33:10,960
+برازايت أيضا لا يسبب اسهال بشكل كبير إلا عند
+
+431
+00:33:10,960 --> 00:33:15,380
+الأطفال أو عند دو المناعة المنخفضة بالإضافة إلى
+
+432
+00:33:15,380 --> 00:33:19,500
+الـGiardia Lamblia طبعا الـGiardia Lamblia واحدة
+
+433
+00:33:19,500 --> 00:33:22,940
+من أشهر الـ pathogens اللي موجودة عندنا في غزة هي
+
+434
+00:33:22,940 --> 00:33:26,380
+الانتميبة استيلوتيكا وهي صديقة الدكتور عبدالله
+
+435
+00:33:26,380 --> 00:33:31,150
+الهندي لأنَّه دائما بيعمل دراسات على الأطفال في
+
+436
+00:33:31,150 --> 00:33:34,330
+مستويات مختلفة في أماكن مختلفة والحمد لله يا رب
+
+437
+00:33:34,330 --> 00:33:37,930
+العالمين يعني بدأ الأرقام تبعتها تنزل في السنوات
+
+438
+00:33:37,930 --> 00:33:42,810
+الأخيرة نتيجة اللي هو وجود التحسن في مستوى البني
+
+439
+00:33:42,810 --> 00:33:48,210
+التحتية للمياه العادية الـ central nervous system
+
+440
+00:33:48,210 --> 00:33:51,230
+زي الـ meningitis، الـ brain abscesses و
+
+441
+00:33:51,230 --> 00:33:54,870
+progressive multifocal leukoencephalopathy اللي
+
+442
+00:33:54,870 --> 00:33:58,490
+بسببه فيروس اسمه JC virus و الـ brain abscess
+
+443
+00:33:58,490 --> 00:34:03,870
+تخيلوا الـ Toxoplasma Gondii اللي هي المشهورة 
+
+444
+00:34:03,870 --> 00:34:06,850
+بالجرثومة عندنا في فلسطين واللي مرتبطة بمين
+
+445
+00:34:06,850 --> 00:34:12,950
+بالإجهاد مرتبطة بالقطط لكن طبائنا الأفاضل يعني نشروا
+
+446
+00:34:12,950 --> 00:34:16,550
+ثقافة بأن معظم حالات الإجهاد كانت من مين من
+
+447
+00:34:16,550 --> 00:34:21,530
+الجرثومة والأسف هذا يعني كان اعتقاد خاطئ ومرروا
+
+448
+00:34:21,530 --> 00:34:26,110
+للناس فأهملوا الأسباب الحقيقية للإجهاد في أنَّه
+
+449
+00:34:26,110 --> 00:34:29,130
+موجود عندهم toxoplasmosis شوفوا الرقم اللي
+
+450
+00:34:29,130 --> 00:34:34,490
+بيحكيلكوا يا بنات من كل عشرة آلاف امرأة حامل والآن 
+
+451
+00:34:34,490 --> 00:34:40,930
+حامل والآن أصيبت بالـ Toxoplasmosis احتمالية
+
+452
+00:34:40,930 --> 00:34:45,760
+الإجهاد واحدة من عشرة آلاف يعني اللي اللي اللي اللي
+
+453
+00:34:45,760 --> 00:34:46,320
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+454
+00:34:46,320 --> 00:34:48,260
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+455
+00:34:48,260 --> 00:34:49,120
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+456
+00:34:49,120 --> 00:34:49,680
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+457
+00:34:49,680 --> 00:34:52,560
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+458
+00:34:52,560 --> 00:34:52,620
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+459
+00:34:52,620 --> 00:34:52,720
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+460
+00:34:52,720 --> 00:34:53,100
+اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي
+
+461
+00:34:53,100 --> 00:35:02,020
+اللي اللي اللي اللي اللي اللي اللي 
+
+462
+00:35:07,450 --> 00:35:10,730
+عندها Erythema اللي هي الـ Toxoplasma Gondii هذا
+
+463
+00:35:10,730 --> 00:35:17,990
+الطفل 99% و 9 من 10 يمكن الـ infection تبقى
+
+464
+00:35:17,990 --> 00:35:22,470
+asymptomatic لكن عند مرضى الـ aids إيش هيعملها؟
+
+465
+00:35:22,470 --> 00:35:29,590
+brain abscess إذا كان هذا المرض بشكل خطوري في حد
+
+466
+00:35:29,590 --> 00:35:32,030
+لطيف عن الـ Toxoplasma لازم أحكيلكوا إياها
+
+467
+00:35:34,890 --> 00:35:42,110
+التوكسو بلازمة طفيل برازايت لا يفقه يعني ما عندهوش
+
+468
+00:35:42,110 --> 00:35:46,970
+ذكاء كبير أو هيك بنعتقد احنا لكن اتطلع و جديش
+
+469
+00:35:46,970 --> 00:35:49,970
+الذكاء تبعه هذا الـ life cycle تبعه أنتِ قلتي وين
+
+470
+00:35:49,970 --> 00:35:54,890
+قطعت لكن جزء من الـ life cycle تبعه الفقران أول ما
+
+471
+00:35:54,890 --> 00:35:58,730
+بصيب بصيب الفقران و أين بصيبها في دماغها بصيب تحب
+
+472
+00:35:58,730 --> 00:36:04,410
+البيسالفقران اللي مشهورة عنها فهو هذا من الـ .. من
+
+473
+00:36:04,410 --> 00:36:10,890
+اللي بيسموه brain modulating parasites يعني طفليات
+
+474
+00:36:10,890 --> 00:36:17,510
+تعدل من سلوك الدماغ تمام؟ فبيخلي الفقران ترغب
+
+475
+00:36:17,510 --> 00:36:21,730
+الذهاب إلى القطط ليش؟ عشان تاكلها طبعا الـ farm مش
+
+476
+00:36:21,730 --> 00:36:25,710
+الذهاب مش المسكين تحت تأثير مين؟ تحت تأثير التكسو
+
+477
+00:36:25,710 --> 00:36:31,090
+بلازموز عشان هو يكمل الـ life cycle طبعا كمان في شغل
+
+478
+00:36:31,090 --> 00:36:34,430
+لجوها مهمة أن الناس اللي بيعملوا حوادث السيارات
+
+479
+00:36:34,430 --> 00:36:40,630
+اللي عندهم antibody لـ toxoplasmosis أكثر من اللي
+
+480
+00:36:40,630 --> 00:36:44,710
+ماعندهمش بمعنى أنَّه قد يكون سبب من أسباب حوادث
+
+481
+00:36:44,710 --> 00:36:47,210
+السيارات أن يكون عند الإنسان إيه؟ toxoplasmosis،
+
+482
+00:36:47,210 --> 00:36:52,560
+ما أعرفش ليش؟ بقولك بيأخر ردة الفعل تعرفين بين حادث
+
+483
+00:36:52,560 --> 00:36:57,900
+عالم الحادث ملي ساكنز أن هي تاخد قرار تضرب break
+
+484
+00:36:57,900 --> 00:37:02,580
+أو ما تضربش break صح؟ فبالتالي وجود تكسب لازمة في
+
+485
+00:37:02,580 --> 00:37:07,240
+أدمغة البشر قد يعيق اللي هي ردة الفعل هذه فقط
+
+486
+00:37:07,240 --> 00:37:13,090
+للسبب في الحوادث، إذا هذا نموذج على برازايف من خلق
+
+487
+00:37:13,090 --> 00:37:17,270
+الله سبحانه وتعالى يعني اللي له هذه القدرة العالية
+
+488
+00:37:17,270 --> 00:37:22,250
+في التحكم في الأدمغة خلّى الفقران تتخلى عن عداءه
+
+489
+00:37:22,250 --> 00:37:26,530
+التاريخي للقطط في سبيل أنَّه يعمل الـ life cycle تبعه
+
+490
+00:37:27,610 --> 00:37:32,230
+الـ I-Retinitis can be caused by CMV طبعا CMV نجم
+
+491
+00:37:32,230 --> 00:37:37,070
+من نجوم الـ HIV يعني من اللي بسبب أمراضها عند مرضى
+
+492
+00:37:37,070 --> 00:37:40,770
+الـ AIDS الكابوس الساركومة في الـ skin كلكم بتعرفوها
+
+493
+00:37:40,770 --> 00:37:45,190
+الـ HHV8 اللي هو الـ human herpes virus type 8
+
+494
+00:37:45,190 --> 00:37:48,870
+والزوستر Varicella zooster بالضعف إلى اللي هو
+
+495
+00:37:48,870 --> 00:37:51,850
+subcutaneous nodules caused by Cryptococcus
+
+496
+00:37:51,850 --> 00:37:56,890
+neoformans واللي Cryptococcus ذكرناها في أكثر مكان
+
+497
+00:37:57,060 --> 00:38:01,520
+وهي من مسببات بالمناسبة التهاب السحايا كريبتوكوكاس
+
+498
+00:38:01,520 --> 00:38:05,140
+نيوفورمانس المرة الجاية إن شاء الله بنكمل بإذن الله
+
+
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a3967beb3db9c77def7aa97a7fda1c2752ff657d
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE_postprocess.srt
@@ -0,0 +1,1992 @@
+1
+00:00:21,160 --> 00:00:23,480
+طيب بسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:23,480 --> 00:00:28,640
+اليوم احنا نتكلم عن فيروس ال aids ويمكن الكل بيعرف
+
+3
+00:00:28,640 --> 00:00:33,640
+انه قبل تلات أيام من هذا اليوم اللي هو الاول من
+
+4
+00:00:33,640 --> 00:00:37,580
+ديسمبر هو اليوم العالمي لل aids كل عام و أنتم بخير
+
+5
+00:00:38,710 --> 00:00:43,030
+طبعا اليوم العالمي لل aids أُقر من مُنظمة الصحة
+
+6
+00:00:43,030 --> 00:00:47,330
+العالمية لتوحيد الجهود العالمية المفذولة لمكافحة
+
+7
+00:00:47,330 --> 00:00:52,090
+هذا المرض الخطير والذي أثر على أو دخل كل دول
+
+8
+00:00:52,090 --> 00:00:54,350
+العالم تقريبا يعني لا ولا دولة في العالم لا ولا
+
+9
+00:00:54,350 --> 00:00:58,250
+دولة فيها مرض ال aids لكن بنسبة متفاوتة نسبة
+
+10
+00:00:58,250 --> 00:01:01,710
+الوفيات الناجمة عن هذا المرض عالية جدا الإصابات
+
+11
+00:01:01,710 --> 00:01:05,830
+السنوية عن هذا المرض ما زالت مرتفعة جدانحن في
+
+12
+00:01:05,830 --> 00:01:12,850
+الوطن العربي يمكن الأقل نسب عالميا، لكن الأعلى
+
+13
+00:01:12,850 --> 00:01:17,470
+وباقية، بمعنى إنه قاعدين في ارتفاع وانت عارفين لما
+
+14
+00:01:17,470 --> 00:01:21,070
+يصير عشرة ويصير عشرين، ايش يعني عشرة وعشرين؟ ضعف
+
+15
+00:01:21,070 --> 00:01:26,400
+العشرين هي ضعف العشرةصحيح الـ20 رقم ضئيل جدا
+
+16
+00:01:26,400 --> 00:01:30,780
+بالمقارنة مع الدول الأخرى، لكن التضاعف اللي حصل هو
+
+17
+00:01:30,780 --> 00:01:33,540
+hundred percent، مائة بالمائة، وبالتالي أنا عندى
+
+18
+00:01:33,540 --> 00:01:36,640
+ارتفاع مائة بالمائة في بعض الدول العربية، وبالتالي
+
+19
+00:01:36,640 --> 00:01:43,070
+في خشية من تفشي أيضا هذا الوباءقبل ما ندخل في مرض
+
+20
+00:01:43,070 --> 00:01:47,110
+الاسم نتعرف على عائلة اللي بتشمل هذا الفيروس وهي
+
+21
+00:01:47,110 --> 00:01:51,230
+عائلة ال retro viruses او retro virida تنقسم الى
+
+22
+00:01:51,230 --> 00:01:57,390
+three sub families الاولى بنسميها عفوا مادخلناش
+
+23
+00:01:57,390 --> 00:02:01,910
+على العائلات هاي العائلات ال oncovirو ال Lentil
+
+24
+00:02:01,910 --> 00:02:06,790
+Verne و ال Spuma Verne هحنحاول نميز بين التلاتة
+
+25
+00:02:06,790 --> 00:02:09,990
+طبعا في منهم واحدة بتعرفوها كويس اللي هي ال Onco
+
+26
+00:02:09,990 --> 00:02:16,110
+Verne دراسته من ال HTLV-1 و ال HTLV-2 و بيشملوا
+
+27
+00:02:16,110 --> 00:02:19,770
+طبعا فينا كمان هنا HTLV-5 ال AIDS كان اسمه في يوم
+
+28
+00:02:19,770 --> 00:02:28,130
+من الأيام HTLV-3 يعني أحد أسماءه الأول كان HTLV-3
+
+29
+00:02:29,270 --> 00:02:32,630
+وخصائص هذه المجموعة انها تعمل immortalization
+
+30
+00:02:32,630 --> 00:02:36,230
+وtransformation لل target cells وشوفنا انها بالفعل
+
+31
+00:02:36,230 --> 00:02:41,450
+تعمل lymphoma و cancer ال Lentivirne اللي بينتمي
+
+32
+00:02:41,450 --> 00:02:47,810
+اليها ال HIV 1 و ال HIV 2 لها علاقة بعائلة بتسبب
+
+33
+00:02:47,810 --> 00:02:51,510
+شغلتين رئيسيتين immunodeficiencies و immunological
+
+34
+00:02:51,510 --> 00:02:54,730
+disorders يعني أشياء متعلقة بالأعصاب و أشياء
+
+35
+00:02:54,730 --> 00:03:00,920
+متعلقة بضعف او انخفاض جهاز المناع الأخيرليس له
+
+36
+00:03:00,920 --> 00:03:06,120
+ارتباط بالأمراض اسمها spuma viruses او human
+
+37
+00:03:06,120 --> 00:03:11,960
+phobia virus وكلمة phom معناها رغبة وسميها كده
+
+38
+00:03:11,960 --> 00:03:15,880
+الفيروس لانه لما نمو على ال cell culture عنا ال
+
+39
+00:03:15,880 --> 00:03:18,900
+bubbles و ال bubbles عاملة زي ايه زي ال phom فسموه
+
+40
+00:03:18,900 --> 00:03:21,900
+human phobia virus و it is not associated with any
+
+41
+00:03:21,900 --> 00:03:26,710
+of the human diseasesإذاً ثلاثة عائلات مختلفة،
+
+42
+00:03:26,710 --> 00:03:31,850
+أنكو، فيرني، لنتي فيرني، سبيوما فيرني، فيروسنا
+
+43
+00:03:31,850 --> 00:03:37,030
+بيتم لأي واحدة منهمللتاني ان انت فيران نرجع نطلع
+
+44
+00:03:37,030 --> 00:03:40,730
+على العائلة ككل ايش ال characteristics العامة لهذه
+
+45
+00:03:40,730 --> 00:03:44,650
+العائلة رقم واحد انه معروف عن عائلة ال
+
+46
+00:03:44,650 --> 00:03:47,050
+retroviruses انها associated with ايه؟ with
+
+47
+00:03:47,050 --> 00:03:51,890
+tumors, leukemias و immunodeficiencies خرجت عن هيك
+
+48
+00:03:51,890 --> 00:03:54,630
+هاي الأمراض اللي بتاعتهم ياما immunodeficiency
+
+49
+00:03:54,630 --> 00:03:59,620
+ياما ال leukemias او ال tumorsكمان شغل المهمة
+
+50
+00:03:59,620 --> 00:04:03,640
+unique to this family اللي هو الـ double genome
+
+51
+00:04:03,640 --> 00:04:07,740
+عندهم نسختان من ال genome سميناهم الـ diploid اللي
+
+52
+00:04:07,740 --> 00:04:11,480
+وجود عنه بوستفسترانديد RNA طبعا احنا عارفين ان
+
+53
+00:04:11,480 --> 00:04:15,020
+البوستفسترانديد RNA في معظم الفيروس اللي درسناها
+
+54
+00:04:15,020 --> 00:04:20,740
+مابحتاجش RNA polymerase مع بيستغل مين؟ بيستغل ال
+
+55
+00:04:20,740 --> 00:04:24,120
+RNA polymerase اللي موجود في الخلية لكن هذا
+
+56
+00:04:24,120 --> 00:04:29,010
+الفيروسكان يجب من مرحلة التكاثر عنده انه يتحول من
+
+57
+00:04:29,010 --> 00:04:34,650
+RNA إلى DNA، ما في خلايانا احنا اي مرحلة بتحول ال
+
+58
+00:04:34,650 --> 00:04:39,150
+RNA إلى DNA، احنا بتحول ال DNA إلى RNA، اللي هو ال
+
+59
+00:04:39,150 --> 00:04:43,710
+flow of information DNA RNA بعدين protein، هنا في
+
+60
+00:04:43,710 --> 00:04:48,230
+خطوة عكسيةوالخطوة العكسية هذه عملها الفيروس حتى
+
+61
+00:04:48,230 --> 00:04:51,270
+يقوم بـ integration لذاته لأنه ماينفعش تعمل
+
+62
+00:04:51,270 --> 00:04:56,110
+integration ل RNA في DNA فاتحول ل DNA ثم عمل
+
+63
+00:04:56,110 --> 00:05:00,190
+integration في ال host genome، إذن genome consist
+
+64
+00:05:00,190 --> 00:05:03,790
+of two copiesالانزيم الانزيم الانزيم الانزيم
+
+65
+00:05:03,790 --> 00:05:04,170
+الانزيم الانزيم الانزيم الانزيم الانزيم الانزيم
+
+66
+00:05:04,170 --> 00:05:06,890
+الانزيم الانزيم الانزيم الانزيم الانزيم الانزيم
+
+67
+00:05:06,890 --> 00:05:12,530
+الانزيم الانزيم الانزيم الانزيم الانزيم الانزيم
+
+68
+00:05:12,530 --> 00:05:19,690
+الانزيم الانزيم الانزيم الانزيم الانزيم
+
+69
+00:05:20,830 --> 00:05:25,610
+واحد انهم associated with tumors, leukemias and
+
+70
+00:05:25,610 --> 00:05:29,610
+immunodeficiencies رقم اتنين double genome او
+
+71
+00:05:29,610 --> 00:05:33,310
+diploid رقم تلاتة لديهم reverse transcription
+
+72
+00:05:33,310 --> 00:05:37,810
+process تعالوا
+
+73
+00:05:37,810 --> 00:05:40,590
+ناخد بعض المعلومات العامة عن الفيروس هنعرف كده
+
+74
+00:05:40,590 --> 00:05:46,620
+أهمية هذا الفيروس وليش العالم عمله يوم عالمHIV أو
+
+75
+00:05:46,620 --> 00:05:52,200
+human immunodeficiency virus هو بالعربي مرض أو
+
+76
+00:05:52,200 --> 00:05:55,920
+فيروس عواز المناعة أو نقص المناعة يعني الإسمين
+
+77
+00:05:55,920 --> 00:06:01,780
+موجودين بشهرة كبيرة عواز المناعة أو نقص المناعةHas
+
+78
+00:06:01,780 --> 00:06:04,800
+now spread to every country in the world and has
+
+79
+00:06:04,800 --> 00:06:07,860
+infected over 40 million people worldwide هذا
+
+80
+00:06:07,860 --> 00:06:12,200
+الكلام في 2009،الان احنا في 2017،اخر تقرير تتكلم
+
+81
+00:06:12,200 --> 00:06:19,980
+عن 70 مليون إنسان أصيبوا بهذا الفيروس حوالي 5
+
+82
+00:06:19,980 --> 00:06:24,240
+مليون إنسان يصابوا سنويا حول العالم بهذا
+
+83
+00:06:24,240 --> 00:06:31,580
+الفيروس،حوالي 3 مليون بيموتوا من هذا الفيروسيبقى
+
+84
+00:06:31,580 --> 00:06:37,940
+سنويًا كل سنة بيموت تلاتة مليون وبيصاب خمسة مليون
+
+85
+00:06:37,940 --> 00:06:42,550
+إشدارفي حدود العام 2000 الإحصائي كانت التراكمية
+
+86
+00:06:42,550 --> 00:06:47,190
+للبوافيات من ال aids كانت حوالي 22 مليون عارفين
+
+87
+00:06:47,190 --> 00:06:50,890
+متى بدأ ال aids احنا بنعرف هنا من ال 84 و 85 يعني
+
+88
+00:06:50,890 --> 00:06:55,790
+مابنعرفوش من زمان يعني من ال 85 ل 2000 كدهش 15 سنة
+
+89
+00:06:55,790 --> 00:07:01,670
+15 سنة إذا في 15 سنة قتل 22 مليون إنسان مرض خطير و
+
+90
+00:07:01,670 --> 00:07:07,310
+فيروس خطيرلذلك يعني نقدر الجهود العالمية اللي
+
+91
+00:07:07,310 --> 00:07:13,290
+مفضولة لمكافحة هذا المعنى The scourge of HIV كلمة
+
+92
+00:07:13,290 --> 00:07:21,160
+scourge يعني البلاء البلاء اللي يسمى HIVكان بشكل
+
+93
+00:07:21,160 --> 00:07:26,160
+خاص مدمرا في sub-saharan Africa في أفريقيا يعني في
+
+94
+00:07:26,160 --> 00:07:30,760
+قرى قد يصل نصف العدد من السكان مصابين بمرض ال aids
+
+95
+00:07:30,760 --> 00:07:36,040
+وهذا رقم ضخم جدا يعني أعلى من أي وبائية في أوروبا
+
+96
+00:07:36,040 --> 00:07:40,510
+وفي الولايات المتحدةكمان في نقطة كتير مهمة ان نسبة
+
+97
+00:07:40,510 --> 00:07:44,110
+النساء البالغات اللي واتي أصابنا بال aids في
+
+98
+00:07:44,110 --> 00:07:47,610
+ازدياد طبعا كانت النسبة الأعلى دايما في صالح .. مش
+
+99
+00:07:47,610 --> 00:07:51,410
+في صالح ضد الرجال بمعنى ان الرجال هو الأكتر إصابة
+
+100
+00:07:51,410 --> 00:07:56,450
+لسببين ان هو أصلا يعني ال aids أول ما اكتشف اكتشف
+
+101
+00:07:56,450 --> 00:08:00,770
+في الرجال المثليين ال homosexual المنحرفين
+
+102
+00:08:03,390 --> 00:08:06,810
+والفئة التانية اللي هم بتوع المخدرات اللي هم اللي
+
+103
+00:08:06,810 --> 00:08:10,450
+بياخدوا IV drugs فالرجال اكثر ايضا عرضة في هذا
+
+104
+00:08:10,450 --> 00:08:14,870
+الجانب لكن اليوم فيه زيادة في نسبة النساء المصابات
+
+105
+00:08:14,870 --> 00:08:20,990
+بهذا الفيروسسمى المرض كما ذكرت human T
+
+106
+00:08:20,990 --> 00:08:26,290
+lymphotropic virus type 3 او HTLV 3 وسمى ايضا
+
+107
+00:08:26,290 --> 00:08:29,470
+lymphadenopathy associated virus ليش سمى بهذا
+
+108
+00:08:29,470 --> 00:08:34,370
+الاسم؟ لان المريض ال aids قلنالكم بيصير جثة متحركة
+
+109
+00:08:34,370 --> 00:08:39,180
+يصاب بعمراض كثيرة من ضمن العمراضالـ lymph node ما
+
+110
+00:08:39,180 --> 00:08:41,600
+انتوا عارفين هي ال check point فلو ما يكون فيش
+
+111
+00:08:41,600 --> 00:08:45,560
+مناعة ال check point بتفشل في مكافحة الأمراض فال
+
+112
+00:08:45,560 --> 00:08:49,260
+lymph node بيصير نفسها inflamed زي اللواز بس في كل
+
+113
+00:08:49,260 --> 00:08:55,100
+الجسم، generalized lymphoadenopathyفبصير المرضى ال
+
+114
+00:08:55,100 --> 00:08:58,500
+aids دايما عندهم المناطق اللي فيها lymph node
+
+115
+00:08:58,500 --> 00:09:02,840
+مؤلمة فبالتالي lymphadenopathy فسموا الفيروس
+
+116
+00:09:02,840 --> 00:09:06,480
+lymphadenopathy associated virus وبعدين كمان سموا
+
+117
+00:09:06,480 --> 00:09:13,320
+اسم تاني aids related virus ARV وبعدين استقرنا على
+
+118
+00:09:13,320 --> 00:09:17,140
+اسم الأخير ال HIV او ال human immunodeficiency
+
+119
+00:09:17,140 --> 00:09:21,270
+virusواللي هي one immunodeficiency virus بيجيب
+
+120
+00:09:21,270 --> 00:09:28,830
+ينجسمهم برضه إلى two genesis HIV1 وHIV2 وكلاهما
+
+121
+00:09:28,830 --> 00:09:32,630
+يسبب indistinguishable AIDS بمعنى انه لا نستطيع
+
+122
+00:09:32,630 --> 00:09:36,310
+نتميز ان ال AIDS هذا اللي بيسببه رقم واحد او رقم
+
+123
+00:09:36,310 --> 00:09:39,930
+اتنين الا من خلال الفحوصات السيرولوجية لكن كشكل
+
+124
+00:09:39,930 --> 00:09:45,140
+اتنين بيعملوا نفس المرض اللي هو AIDSعلى عكس إخوته
+
+125
+00:09:45,140 --> 00:09:48,580
+من العيلة الـHTLV اللي كانوا بيعملوا
+
+126
+00:09:48,580 --> 00:09:53,280
+immortalization، هذاش بيعمل killing لالـinfected
+
+127
+00:09:53,280 --> 00:09:56,800
+cells، it kills or damages cells of the body
+
+128
+00:09:56,800 --> 00:10:00,400
+immune system. HIV progressively destroyed the
+
+129
+00:10:00,400 --> 00:10:03,080
+body ability to fight infection and certain
+
+130
+00:10:03,080 --> 00:10:06,080
+cancers.لان نعرف ان الجهاز المناه هو المسئول عن
+
+131
+00:10:06,080 --> 00:10:10,880
+مكافحة العدوى واش كمان مكافحة أيضا السرطانات اذا
+
+132
+00:10:10,880 --> 00:10:14,700
+مافيش جهاز مناه يبقى ال infection غير مكافحة و
+
+133
+00:10:14,700 --> 00:10:18,360
+ايضا السرطانات غير مكافحة وبتالي بيظهر عليه اعراض
+
+134
+00:10:18,360 --> 00:10:29,840
+من هذا او من تلك الأمراض الاشخاص
+
+135
+00:10:29,840 --> 00:10:35,950
+المشخصين بال aids سوف يطورواعدوى أو انتهانات مهددة
+
+136
+00:10:35,950 --> 00:10:40,390
+لحياة الإنسان، مهددة لحياة الإنسان، طالعة من مين؟
+
+137
+00:10:40,390 --> 00:10:46,330
+من فيروس و بكتيريا عادة لا تسبب أدل مين للـnormal
+
+138
+00:10:46,330 --> 00:10:50,010
+individuals، يبقى، إيش بنسمي هذه الأنواع من
+
+139
+00:10:50,010 --> 00:10:53,030
+الميكروبات؟ opportunistic pathogen أو
+
+140
+00:10:53,030 --> 00:10:57,960
+opportunistic infection للمرض نفسهاللوحة اللي
+
+141
+00:10:57,960 --> 00:11:03,880
+أمامنا بتوضح لنا بعض الصفات للـHIV-1 وHIV-2 كلا
+
+142
+00:11:03,880 --> 00:11:07,640
+هما بينتقل عبر اللي هو ال sexual contact blood
+
+143
+00:11:07,640 --> 00:11:12,680
+from mother to child يعني trans-placental أو خلال
+
+144
+00:11:12,680 --> 00:11:17,380
+الولادة أو حتى من ال breast milk يعني في التلات
+
+145
+00:11:17,380 --> 00:11:21,840
+حالات ممكن ينتقل من الأم إلى مش hundred percent ال
+
+146
+00:11:21,840 --> 00:11:26,290
+transmissionقد يتراوح من خمستاشر بالمائة إلى خمسين
+
+147
+00:11:26,290 --> 00:11:30,250
+بالمائة بمعنى انه احتمالات ان الانتقال من خمستاشر
+
+148
+00:11:30,250 --> 00:11:34,970
+يعني مش اكيد الانتقال both can cause
+
+149
+00:11:34,970 --> 00:11:38,010
+indistinguishable aids كمان مرة ال aids اللي
+
+150
+00:11:38,010 --> 00:11:43,000
+بيسببوا HIV one و two مابينفرجهم مش عن بعضHIV-1 هو
+
+151
+00:11:43,000 --> 00:11:47,960
+البرومينانت فيروس عشان الجملة اللى عاجباله لإنه
+
+152
+00:11:47,960 --> 00:11:54,200
+HIV-2 أقل سهولة الترانزميشن يعني بينتقلش بسهولة
+
+153
+00:11:54,200 --> 00:12:00,760
+هذا معناته والتاني شماله بينتقل بسهولة في نقطة
+
+154
+00:12:00,760 --> 00:12:05,590
+كتير مهمة بالنسبة لHIV-1 انه عندهhigh rate of
+
+155
+00:12:05,590 --> 00:12:09,230
+replication وبالتالي بيصير عنده mutation بشكل
+
+156
+00:12:09,230 --> 00:12:14,790
+rapid لذلك بنلاقي منه كتير subtype يبقى hiv-1 يلو
+
+157
+00:12:14,790 --> 00:12:20,610
+subtypes عديدة وهذا أحد أسباب عدم قدرتنا على إنتاج
+
+158
+00:12:20,610 --> 00:12:24,910
+vaccine بشكل جيد وحنشوف كمان شوية في أحد اللوحات
+
+159
+00:12:24,910 --> 00:12:30,570
+الكلام بيدور حول كيف للجهاز للفيروس أن يخدع جهاز
+
+160
+00:12:30,570 --> 00:12:36,870
+المناع فيروس ذكي وعنده قدرات خاصةبالنسبة للـ HIV-1
+
+161
+00:12:36,870 --> 00:12:42,510
+نحن نعرف إن الفترة ما بين دخول الفيروس و بين ظهور
+
+162
+00:12:42,510 --> 00:12:46,330
+الأعراض للـ HIV تتراوح لكن هي في الآخر طويلة هي
+
+163
+00:12:46,330 --> 00:12:53,190
+فترة طويلة غالبا بقى بتكون أطول لما يكون المسبب
+
+164
+00:12:53,190 --> 00:12:57,110
+بالـ AIDS هو HIV-9 يعني الفترة الـ incubation
+
+165
+00:12:57,110 --> 00:13:03,230
+بتكون مالها أطول من HIV-1 الشكل اللي أمامنا هو
+
+166
+00:13:03,230 --> 00:13:07,810
+الشكل الجميل لهذا الفيروسطبعا على طول ما حدر بنشوف
+
+167
+00:13:07,810 --> 00:13:13,290
+احنا double genome بيعطينا إي حق مين بال retro
+
+168
+00:13:13,290 --> 00:13:17,890
+virus و خاصة لما نشوف منه انه جدتين الحمر هدولة
+
+169
+00:13:17,890 --> 00:13:21,890
+اللي ماشي هدولة هدولة معبرة عن الانزيم الاسمه
+
+170
+00:13:21,890 --> 00:13:27,410
+reverse transcriptase طبعا فينا envelope و فينا ال
+
+171
+00:13:27,410 --> 00:13:32,010
+matrix و فينا ال core في هذا ال particle التوضيحية
+
+172
+00:13:33,690 --> 00:13:38,110
+هنا بدى اتأكد على ان ال GP كلمة GP مانعش ال
+
+173
+00:13:38,110 --> 00:13:42,610
+Lycoprotein ال sparks اللي موجودة من أهمهم ان اللي
+
+174
+00:13:42,610 --> 00:13:48,750
+هم ال GP120 و ال GP41 هدول مش موجودين في مين في ال
+
+175
+00:13:48,750 --> 00:13:54,070
+HTLV1 كان في مقابلهم أرقام أخرى غير ال GP120 و 41
+
+176
+00:13:54,070 --> 00:13:59,030
+طبعا هنشوف كمان شوية كمان مرهانة ال double genome
+
+177
+00:13:59,030 --> 00:14:04,970
+و يقولنا اللي هو ال RNA polymeraseطالع على اللوحة
+
+178
+00:14:04,970 --> 00:14:08,590
+اللي على جانب هاي الـ T cell اللي هي CD4 أو الـ
+
+179
+00:14:08,590 --> 00:14:12,890
+Macrophage بيكون في عليها دمعة CD4 Receptor وفيها
+
+180
+00:14:12,890 --> 00:14:18,290
+اسمها Co-Receptor، Co-Receptor فالـ GP121 برتبط مع
+
+181
+00:14:18,290 --> 00:14:24,750
+اللي هو ال .. ال .. ال .. ال CD4 Receptor و ال GP1
+
+182
+00:14:24,750 --> 00:14:29,670
+.. ال GP41 برتبط مع ال Co-Receptorالعام بعد الحالة
+
+183
+00:14:29,670 --> 00:14:33,210
+ال .. ال .. ال binding لل two receptors اللي هو ال
+
+184
+00:14:33,210 --> 00:14:35,510
+receptor الأصلي و ال core receptor بيعمل ال
+
+185
+00:14:35,510 --> 00:14:39,710
+binding قوي و بيعمل ال triggering لل endocytosis
+
+186
+00:14:39,710 --> 00:14:43,230
+انه .. انه .. ان الخلية تاخد مين؟ تاخد الفيروس إلى
+
+187
+00:14:43,230 --> 00:14:51,590
+داخل أو إلى داخلةبشكل لطيف وخفيف بنوضح ال life
+
+188
+00:14:51,590 --> 00:14:55,210
+cycle تبع ال HIV هاي ال ايه ال virus ايه ده ارتبط
+
+189
+00:14:55,210 --> 00:14:59,130
+مع ال CD4 و ال CCR5 هو ال co receptor اللي احنا
+
+190
+00:14:59,130 --> 00:15:02,930
+حكينا عنه قبل قليل صارله internalization بيصيرله
+
+191
+00:15:02,930 --> 00:15:06,830
+uncoating بعد ال uncoating بيصير في عندنا reverse
+
+192
+00:15:06,830 --> 00:15:12,390
+transcription بتحول ال RNA إلى DNA بعدين بيصيرله
+
+193
+00:15:12,390 --> 00:15:18,310
+transport إلىالناوية وهناك في الناوية بيصير له
+
+194
+00:15:18,310 --> 00:15:23,090
+integration داخل الفيروس، بعدين بيصير فيه
+
+195
+00:15:23,090 --> 00:15:29,030
+transcription، ال RNA بيطلع خارج الناوية عشان يصير
+
+196
+00:15:29,030 --> 00:15:34,540
+له translationو بعدين بيصير في عملية طبعا في جزء
+
+197
+00:15:34,540 --> 00:15:38,480
+من ال life cycle مفقود هنا هو انه جزء من ال من ال
+
+198
+00:15:38,480 --> 00:15:43,020
+core تبع ال virus بقعد بيرجع لمين؟ بيرجع للنواة
+
+199
+00:15:43,020 --> 00:15:47,080
+بيصير له maturation وبعدين بطلع إلى الخارج طبعا
+
+200
+00:15:47,080 --> 00:15:49,940
+الخروج عن طريق اللي وجودنا ال budding وفي ال
+
+201
+00:15:49,940 --> 00:15:52,540
+budding بياخد ال spikes تبعته اللي من ضمنها ال
+
+202
+00:15:52,540 --> 00:15:55,300
+GP120 وال GP41
+
+203
+00:15:57,590 --> 00:16:02,070
+الـ maturation يُقارنها بالفترة في الـ budding أو
+
+204
+00:16:02,070 --> 00:16:06,030
+حتى بعدما يصبح الفيروس بيصير له الـ maturation
+
+205
+00:16:06,030 --> 00:16:10,110
+احنا
+
+206
+00:16:10,110 --> 00:16:14,930
+درسنا في الـ HTLV فيروسات جونا ال retro viruses
+
+207
+00:16:14,930 --> 00:16:19,350
+بتحتوي على نوعين من الجينات سمناهم structural gene
+
+208
+00:16:20,580 --> 00:16:24,940
+وregulatory genes وكنا فيه structural genes common
+
+209
+00:16:24,940 --> 00:16:30,300
+to all retroviruses زي الجاج والبول والانف والجاج
+
+210
+00:16:30,300 --> 00:16:35,720
+بتطلعنا بروتينات زي بروتينات 24 و17 و7 اللي هم
+
+211
+00:16:35,720 --> 00:16:39,160
+موجودين في ال نوكل وكبسيد و ال B17 اللي موجود في
+
+212
+00:16:39,160 --> 00:16:41,340
+من؟ في ال matrix كلكم بتعرف شو ال matrix؟ ال
+
+213
+00:16:41,340 --> 00:16:44,600
+matrix اللي هو اللي بين الكبسيد وين؟ ال envelope
+
+214
+00:16:45,630 --> 00:16:49,630
+وال pull هو اللي بتطلعنا الانزيمات الثلاثة الشهيرة
+
+215
+00:16:49,630 --> 00:16:52,790
+في ال retrovirus اللي هي ال reverse transcriptase
+
+216
+00:16:52,790 --> 00:16:57,850
+و ال protease و ال integrase جاج بول انف ال انف
+
+217
+00:16:57,850 --> 00:17:03,350
+جاية من كلمة envelope لانه بتطلعنا مين ال GP120 و
+
+218
+00:17:03,350 --> 00:17:07,830
+ال GP41 هذا اللي واش شفناهمفى ال .. فى ال envelope
+
+219
+00:17:07,830 --> 00:17:11,270
+مظبوط فى النقل هون فى ال envelope دعنا نطلع على ال
+
+220
+00:17:11,270 --> 00:17:15,210
+functions قولنا ال جيب ال ال ال P 247 ويومولودين
+
+221
+00:17:15,210 --> 00:17:19,710
+فى ال nuclear capsule ال P 17 موجود فى ال matrix
+
+222
+00:17:19,710 --> 00:17:22,730
+طبعا ال matrix اللى قولنالك هو عبارة عن support ما
+
+223
+00:17:22,730 --> 00:17:26,730
+بين يعني مانفعش يكون في عندي membrane وفي عندي
+
+224
+00:17:26,730 --> 00:17:32,110
+capsid وفراغ بينهم لازم يكون فى matrix يعبي هذا
+
+225
+00:17:32,110 --> 00:17:35,870
+اللى هو الفراغالـ Reverse transcriptase وظيفته
+
+226
+00:17:35,870 --> 00:17:39,590
+عرفناها أن نحول الـ RNA إلى الـ DNA لبروتياز
+
+227
+00:17:39,590 --> 00:17:46,310
+فاكرينه؟ لما قلنا ال precursor polypeptide بيقطع
+
+228
+00:17:46,310 --> 00:17:52,050
+الـ integrase هو المسئول عن عملية الدمج، الـ DNA
+
+229
+00:17:52,050 --> 00:17:54,130
+بتاع الفيروس اللي اتكون حديثا بالـ Reverse
+
+230
+00:17:54,130 --> 00:17:58,730
+transcriptase في our own cellular DNAالـ GP120
+
+231
+00:17:58,730 --> 00:18:01,750
+اللي هو مسؤول عن الـ Attachment لـ CD4 ريسبتور
+
+232
+00:18:01,750 --> 00:18:05,950
+شوفناها في التكلمة قبل قليل أيضا ال GP41 بيساعد
+
+233
+00:18:05,950 --> 00:18:09,110
+انه قلنالكوا بارتباطه بال core receptor بيساعد في
+
+234
+00:18:09,110 --> 00:18:12,010
+ال fusion مع ال host cell و الترابيسي اللي هو
+
+235
+00:18:12,010 --> 00:18:17,730
+internalization إلى الداخل هذا يعني البروتينات
+
+236
+00:18:17,730 --> 00:18:22,290
+الستركتورية طيب نيجي لل regulatory protein برضه
+
+237
+00:18:24,570 --> 00:18:31,590
+في منها شبيه شفناها في وين في ال HTLV مثلا شفنا
+
+238
+00:18:31,590 --> 00:18:37,770
+تكس تاكس عفوا تاكس وشفنا ركس يعني نفس الأحرف اللي
+
+239
+00:18:37,770 --> 00:18:42,890
+اتغير هنا من الحرف الأخير هنا تات بدل تاكس وهنا رف
+
+240
+00:18:42,890 --> 00:18:47,710
+بدل ركس تعالوا نشوف التات واتذكروا التات هو كان
+
+241
+00:18:47,710 --> 00:18:53,190
+الأمجين في ال HTLV one مين متذكرش كانت وظيفته؟
+
+242
+00:18:56,880 --> 00:19:03,720
+Tax Gene لأ اقرأوا الوظيفة الموجودة على الصبورة
+
+243
+00:19:03,720 --> 00:19:06,660
+الآن وشوفوا الشبه بين الاتنين activation of ..
+
+244
+00:19:06,660 --> 00:19:09,820
+اصلا اسمه Transactivation ل Transcription
+
+245
+00:19:09,820 --> 00:19:12,960
+Transactivator ل Transcription هي مع التات
+
+246
+00:19:12,960 --> 00:19:20,200
+Transactivation of Transcription it activates of
+
+247
+00:19:20,200 --> 00:19:24,230
+transcription of viral genesهداك كان يعمل
+
+248
+00:19:24,230 --> 00:19:28,530
+activation للـ transcription of both viral and
+
+249
+00:19:28,530 --> 00:19:32,930
+cellular gene وهذا هو السبب لأنه صار لنا cancer في
+
+250
+00:19:32,930 --> 00:19:37,230
+الفيروس التاني الـHTLV انه عمل activation لكل ال
+
+251
+00:19:37,230 --> 00:19:41,390
+transcription وبالتالي كل الجين صار لها expression
+
+252
+00:19:41,390 --> 00:19:48,080
+صار في عندي uncontrolled growthالرف بيساعد ال
+
+253
+00:19:48,080 --> 00:19:51,520
+protein تبعه بيساعد على ال transport of late mRNA
+
+254
+00:19:51,520 --> 00:19:55,300
+from the nucleus to the cytoplasm كلكوا بتعرفوا
+
+255
+00:19:55,300 --> 00:20:00,160
+أنه ال mRNA لازم يطلع من النواء إلى ال cytoplasm
+
+256
+00:20:00,160 --> 00:20:05,500
+عشان يصير له translation هذا الرف بيساعد في نقل ال
+
+257
+00:20:05,500 --> 00:20:08,880
+late mRNA طبعا عارفين إيش يعني late mRNA؟ في early
+
+258
+00:20:08,880 --> 00:20:15,220
+mRNA تذكرينه من أول الفصل early و lateفبالإضافة
+
+259
+00:20:15,220 --> 00:20:17,380
+إلى الجينات اللي ذكرناها من اللي قلنا عنها
+
+260
+00:20:17,380 --> 00:20:22,720
+regulatory في حد اسمها accessory genes وتعطيكوا
+
+261
+00:20:22,720 --> 00:20:28,060
+إيه حق كلمة accessory؟ إيه اسمها accessory؟ زيادة،
+
+262
+00:20:28,060 --> 00:20:30,960
+في حد اسمها زيادة؟ في فيروس زيادة، في حد اسمها
+
+263
+00:20:30,960 --> 00:20:34,720
+زيادة؟ مافي حد اسمها زيادة، لكن المقصود فيها إنها
+
+264
+00:20:34,720 --> 00:20:38,700
+مش essential أو مش required لل replication، مش
+
+265
+00:20:38,700 --> 00:20:43,150
+required لل replicationيعني ممكن نشيلها و الفيروس
+
+266
+00:20:43,150 --> 00:20:49,590
+أشماله يتكاثر، لكن بشرط مايكونش فيه مناعة، يتكاثر
+
+267
+00:20:49,590 --> 00:20:53,530
+لو مايكونش فيه حد ضد الفيروس، يعني ممكن هذا الكلام
+
+268
+00:20:53,530 --> 00:20:58,350
+كويس لل cell culture لو جسجصنا الجينات وحطينا ال
+
+269
+00:20:58,350 --> 00:21:01,690
+HIV في cell culture ممكن يتكاثر بسهولة بدون هذه
+
+270
+00:21:01,690 --> 00:21:12,550
+الجينةنف و VIF و VPR و VPU هذه الأكسيروجين لها
+
+271
+00:21:12,550 --> 00:21:17,830
+وظائف رائعة جدا تعالوا نطلع على أول واحد نف
+
+272
+00:21:19,110 --> 00:21:23,750
+والجين بينكتب ببنات في خط مائل وكله small الجين و
+
+273
+00:21:23,750 --> 00:21:27,710
+ال protein تبعه بينكتب مش بمائل و أول حرف ماله
+
+274
+00:21:27,710 --> 00:21:31,370
+capital يعني هذا ال نف هو الجين و هذا مش ماله هذا
+
+275
+00:21:31,370 --> 00:21:35,730
+ال protein تبع هذا الجين إذا ال gene بيكتب بطريقة
+
+276
+00:21:35,730 --> 00:21:39,270
+مائلة بينما ال product بتبعته بتكتب بالطريقة هذه
+
+277
+00:21:39,270 --> 00:21:42,610
+الأول حرف بيكون capital مش زي هنا small
+
+278
+00:21:46,480 --> 00:21:50,720
+كلكم بتعرفوا إنه الـ cytotoxic T cell و ال natural
+
+279
+00:21:50,720 --> 00:21:55,240
+killer cells بيلفلفوا على جهاز المناع، أعفن على
+
+280
+00:21:55,240 --> 00:21:58,900
+الخلايا في الجسم، كل يوم بيطلعوا، كل لحظة بيطلعوا
+
+281
+00:21:58,900 --> 00:22:03,840
+عليهمنورمال، نورمال، نورمال، كيف بيعرف إنه نورمال
+
+282
+00:22:03,840 --> 00:22:07,140
+ولا مش نورمال؟ إما decreased expression أو
+
+283
+00:22:07,140 --> 00:22:12,180
+increased expression أو فيه عندي new genes مش
+
+284
+00:22:12,180 --> 00:22:15,540
+موجودة أصلا، يعني أو عفوا، new proteins expressed
+
+285
+00:22:15,540 --> 00:22:19,080
+على ال surface تبع الخلايا، مش من ضمن اللي هو ال
+
+286
+00:22:19,080 --> 00:22:23,700
+normal cells، إذا ال T cell راح على التغير على هذه
+
+287
+00:22:23,700 --> 00:22:29,480
+الخلايا، بتهاجمها و بتقتلهاطب كيف الـ HIV بده يخفي
+
+288
+00:22:29,480 --> 00:22:34,880
+نفسه عن باقي جهاز المناعة من خلال الـ Nif gene؟
+
+289
+00:22:34,880 --> 00:22:41,180
+كيف؟ بيعمل decrease للـ CD4 proteins و decrease لل
+
+290
+00:22:41,180 --> 00:22:45,080
+class 1 MHC protein على ال surface تبع ال infected
+
+291
+00:22:45,080 --> 00:22:51,150
+cellsهذا الـ decrease هو الأصل يصير increase،
+
+292
+00:22:51,150 --> 00:22:55,410
+الأصل يصير لأن هذه الخلية شمالها مصابة بالفيروس،
+
+293
+00:22:55,410 --> 00:23:00,270
+عشان تقنع نفسها لجهاز المناعة، الأصل تزيد من إنتاج
+
+294
+00:23:00,270 --> 00:23:05,870
+مين ل class I MHC، هنا بيعمل decrease، يبقى معنا
+
+295
+00:23:05,870 --> 00:23:10,150
+الحكيش بيصير الـCytosectin مر عنها وتفكرها normal،
+
+296
+00:23:10,150 --> 00:23:15,900
+مش هتعرف إن فيه جواها خطرهذا ممكن يؤدي إلى ان الـ
+
+297
+00:23:15,900 --> 00:23:18,980
+.. ال .. ال .. الـ cytocytic cell اللي جاي تقتل
+
+298
+00:23:18,980 --> 00:23:22,220
+الخلية إذا ما نجاتش إليها دور إنه يصير فيها
+
+299
+00:23:22,220 --> 00:23:26,460
+activation لل-apoptosis و هي نفسها اللي اتموت و
+
+300
+00:23:26,460 --> 00:23:31,240
+هذا لقول جين مهم جدا في ال viralness أو ال
+
+301
+00:23:31,240 --> 00:23:35,360
+pathogenesis للـSIV إيش دخل الـSIV؟ احنا مش كدا مع
+
+302
+00:23:35,360 --> 00:23:43,810
+مين؟ عن HIV، إيش الـSIV هذا؟اسمه أحد النظريات اللي
+
+303
+00:23:43,810 --> 00:23:49,510
+بتتكلم عن نشوء مرض ال AIDS عشان تتعرفوا أن كل إشي
+
+304
+00:23:49,510 --> 00:23:54,790
+في الدنيا هنا يعني موجود فيه اتزان رهيب الغابات
+
+305
+00:23:54,790 --> 00:23:58,950
+اللي .. اللي موجود فيها القرود و الحيوانات الأخرى
+
+306
+00:23:58,950 --> 00:24:02,930
+احنا عشان عملنا كبشر أول ما صار لنا منشير كهربا و
+
+307
+00:24:02,930 --> 00:24:08,250
+دوات و جرفات راحنا إيه؟ انجبت على خشب و كتير من
+
+308
+00:24:08,250 --> 00:24:13,490
+الغابات تآكلتالفيروس كان عايش مع الجرود هناك مبسوط
+
+309
+00:24:13,490 --> 00:24:17,530
+و مكيف لأن الجرود تبقوا معاه مبسوطين فهو بتتقل
+
+310
+00:24:17,530 --> 00:24:22,490
+بينهم و بيمرض و فيه اتزان في الموضوع لأن الشجر خف
+
+311
+00:24:22,490 --> 00:24:26,950
+الجرود مالها خفت الفيروس الزعلي جالك انت وين وديته
+
+312
+00:24:26,950 --> 00:24:31,490
+.. اه وين وديته ال .. ال host تبعي طب هو اللي
+
+313
+00:24:31,490 --> 00:24:35,570
+هوريكوا انا غير انتقل لمين للبناء ادمي و على فكرة
+
+314
+00:24:35,570 --> 00:24:40,470
+كل فترة و فترة بيجينا زي ما قلتوا ايبولا تقلفيه
+
+315
+00:24:40,470 --> 00:24:44,630
+boundaries المفروض ان في حدود بيننا وبين الفيروسات
+
+316
+00:24:44,630 --> 00:24:49,730
+ال animal viruses كل فترة وفترة بيتعداها او بيتعدا
+
+317
+00:24:49,730 --> 00:24:53,450
+بعض من هذه الفيروسات الحادث الحيواني الى الحادث
+
+318
+00:24:53,450 --> 00:24:59,150
+الادمى وهناك نظرية تقول انه لان ال SIV معناها
+
+319
+00:24:59,150 --> 00:25:03,250
+simian immunodeficiency virus وكلمة simian معناها
+
+320
+00:25:03,250 --> 00:25:07,400
+قرد قرودفهذا ال .. ال H .. يعني AIDS القرود AIDS
+
+321
+00:25:07,400 --> 00:25:10,620
+القرود فهناك نظرية بتقول انه .. ان ال AIDS أصلا
+
+322
+00:25:10,620 --> 00:25:15,660
+نشأ من وين؟ نشأ من اللي هو القرود و أصاب الإنسان و
+
+323
+00:25:15,660 --> 00:25:18,540
+ال .. و النظرية بتقول أنه المرض موجود من سنة الف
+
+324
+00:25:18,540 --> 00:25:23,620
+وتسعمائة و أربعين أو أقل من ذلك لكن لما وصل له و
+
+325
+00:25:23,620 --> 00:25:27,960
+اتأقلم مع الإنسان يعني ظهر في الثمانيات القرن اللي
+
+326
+00:25:27,960 --> 00:25:32,610
+هو المرضإذا أنا عارف ايش يعنيه؟ SIV Simian
+
+327
+00:25:32,610 --> 00:25:39,050
+Immunodeficiency Virus، أرجو أنه فكرة إنه إذا أحنا
+
+328
+00:25:39,050 --> 00:25:43,070
+كبشر بنقوم بأعمال، فيه consequences لهذه الأعمال
+
+329
+00:25:44,040 --> 00:25:47,960
+وأنا ذكرتلكم سابقا ان بعض الأحيان احنا بنحس حالنا
+
+330
+00:25:47,960 --> 00:25:53,860
+مشكلة صح؟ لكن بنكون واقعا اما خلقنا مشكلة كبيرة
+
+331
+00:25:53,860 --> 00:25:59,800
+وكما قال أحدهم بأن مشاكل اليوم مشاكلنا اليوم هي
+
+332
+00:25:59,800 --> 00:26:05,560
+حلول أو نتائج حلول الأمسو احنا من قبل نحاول نحل
+
+333
+00:26:05,560 --> 00:26:09,660
+مشاكل و نخلق مشاكل و هذا الكلام كمان شفناه في
+
+334
+00:26:09,660 --> 00:26:13,480
+موضوع استخدام البشر لل antibiotic المفرط ان احنا
+
+335
+00:26:13,480 --> 00:26:16,740
+نعم حلنا مشكلة الأمراض الماضية جزئيا لكن خلقنا
+
+336
+00:26:16,740 --> 00:26:21,300
+مشاكل أخرى كثيرة السكر و الضغط و أمراض الشرايين و
+
+337
+00:26:21,300 --> 00:26:25,400
+ايه الاخري فيجب انتبه ان الإنسان لابد ان يعيش in
+
+338
+00:26:25,400 --> 00:26:30,340
+harmony with his environment لازم يعني بتناغم مع
+
+339
+00:26:30,340 --> 00:26:36,300
+البيئة ولا يستغل البيئة أقصى استغلالطيب هد حاضر
+
+340
+00:26:36,300 --> 00:26:42,220
+اتنين النف نيجي لل VIF انهانس اكتفتي انهانس
+
+341
+00:26:42,220 --> 00:26:47,160
+انفكتفتي ايش يعني انهانس انفكتفتي بساعد القدرة على
+
+342
+00:26:47,160 --> 00:26:50,560
+انهي يعمل انفكشن من خلال ايش؟ في انزيم يبنيت عننا
+
+343
+00:26:50,560 --> 00:26:54,480
+احنا احنا احنا ك host اسمه apopeic 3G
+
+344
+00:26:57,690 --> 00:27:04,530
+APOPEC3G هذا الانزيم يبدو انه مخصص لإحداث تفرات في
+
+345
+00:27:04,530 --> 00:27:07,710
+الريتروفيروس يعني الانزيم اللي احنا فبيعمل تفرات
+
+346
+00:27:07,710 --> 00:27:11,310
+في الريتروفيروس وكلمة hyper mutation يعني تفرات
+
+347
+00:27:11,310 --> 00:27:15,270
+بشكل ايه؟ بشكل كبير لدرجة ان الفيروس هيصير من
+
+348
+00:27:15,270 --> 00:27:19,110
+التفرات هذه غير قادر على انه يتكاثر يبقى فيها نحن
+
+349
+00:27:19,110 --> 00:27:23,410
+دفاع ضد الريتروفيروس ايش اسمه؟ APOPEC3G
+
+350
+00:27:25,460 --> 00:27:31,980
+للأسف ال VIF بيعطل هذا الانزيم يعني مفضل فيروس
+
+351
+00:27:31,980 --> 00:27:36,060
+جاية معاه إيه؟ معاه سلاح يعطل السلاح تابعنا اللي
+
+352
+00:27:36,060 --> 00:27:41,000
+هو موجهة ضد هذا الفيروس وصلت صورة فال VIF إيه اللي
+
+353
+00:27:41,000 --> 00:27:45,020
+هو أهمية كبرى؟ بإنه بيمنع الانزيم اللي بيخرب ال
+
+354
+00:27:45,020 --> 00:27:50,590
+retrovirusالتالت اللي هو ال VPR ال transport viral
+
+355
+00:27:50,590 --> 00:27:52,890
+core قلت له ال core قبل شويه انا في ال .. في ال ..
+
+356
+00:27:52,890 --> 00:27:56,010
+في ال life cycle فيش ناجس انه في مرحلة مرحلة بناخد
+
+357
+00:27:56,010 --> 00:27:59,390
+ال core تبع ال .. ال .. ال .. ال virus بيرجع على
+
+358
+00:27:59,390 --> 00:28:05,430
+مين على انه فال VPR هو اللي بيوصله الى انه ال VPU
+
+359
+00:28:05,430 --> 00:28:09,950
+بيعمل enhancement ل ال variant release من ال cells
+
+360
+00:28:09,950 --> 00:28:12,570
+فاكرين؟ شوفوا انا قبل شويه احنا بيعمل bodyingزي
+
+361
+00:28:12,570 --> 00:28:17,110
+الـ Neuromanidase في الانفلونزا مش هو كان مسئول عن
+
+362
+00:28:17,110 --> 00:28:20,890
+قص الفيروس و إخراجه للخارج فهي لأن ال VPU هو
+
+363
+00:28:20,890 --> 00:28:25,450
+المسئول عن أو بيحسن من قدرة الفيروس على الخروج إلى
+
+364
+00:28:25,450 --> 00:28:26,970
+خارج الخلينة
+
+365
+00:28:29,810 --> 00:28:36,310
+So what aids أصعب ال CD4 cells ال CD4 cells is
+
+366
+00:28:36,310 --> 00:28:39,290
+considered by many as the maestro of the immune
+
+367
+00:28:39,290 --> 00:28:43,910
+system المعيستر هو اللي بيعمل organization أو
+
+368
+00:28:43,910 --> 00:28:47,350
+orchestration للجهود تبع كل الناس اللي موجودين
+
+369
+00:28:47,350 --> 00:28:52,390
+حواليه القاعدة الأوركسترية مش موجودة وبنبدأ
+
+370
+00:28:52,390 --> 00:28:55,990
+المعزوفة تبعتنا هذا بتطبل هذا بتخبط هذا بتعمل
+
+371
+00:28:55,990 --> 00:29:00,600
+هتطلع عنا إشي غالبا مش هتطلع عنا إشيالجهاز المنعه
+
+372
+00:29:00,600 --> 00:29:07,580
+بدأ او بدأ يكون بدون رأس مالوش موجه يعني اذا اردت
+
+373
+00:29:07,580 --> 00:29:12,000
+ان تقتل الأفع فضل بالرأس بيروس ال aids اجى على رأس
+
+374
+00:29:12,000 --> 00:29:15,780
+جهاز المنعه اللي هي ال CD4 والماكرو فاجه هو بصير
+
+375
+00:29:15,780 --> 00:29:18,540
+من نوعين من الخلايا اللي هم ال CD4 تيه البرسيل
+
+376
+00:29:18,540 --> 00:29:26,360
+والماكرو فاجهوبالتالي نحن فقدنا يا بنات أهم أنصر
+
+377
+00:29:26,360 --> 00:29:30,220
+أو أهم عناصر جهاز المناعة ولو لا وجود المناعة اللي
+
+378
+00:29:30,220 --> 00:29:32,300
+سمناها innate immune system بتعرفوها ال innate
+
+379
+00:29:32,300 --> 00:29:37,420
+immune system الجلد ال stomach acid مصبوط اللي في
+
+380
+00:29:37,420 --> 00:29:41,570
+الأذن الشمع هذه اسمها innate immune systemاللي لو
+
+381
+00:29:41,570 --> 00:29:45,670
+انها مش موجودة، بتكون تتخيلوا الإنسان الآن هو جثة
+
+382
+00:29:45,670 --> 00:29:50,370
+تمشي أو تتحرك على الأرض، كل شيء ممكن يصيبه،
+
+383
+00:29:50,370 --> 00:29:53,090
+pseudomonas aeruginosa اللي هي opportunistic
+
+384
+00:29:53,090 --> 00:29:56,830
+pathogen، candida albicans، حتى الحشرات هتطفل
+
+385
+00:29:56,830 --> 00:30:02,210
+عليه، إذن هو فقد الجهاز المناعة اللي هو ال
+
+386
+00:30:02,210 --> 00:30:06,060
+adaptive immune system، ضايل عنده هشمينالـ innate
+
+387
+00:30:06,060 --> 00:30:10,000
+immune system اللي هو يعني زي الجلد و الشعر اللي
+
+388
+00:30:10,000 --> 00:30:13,940
+في الأنف و ال acid اللي موجود في ال mind لذلك هو
+
+389
+00:30:13,940 --> 00:30:16,960
+عرض للإصابة ب opportunistic infection كثيرة من
+
+390
+00:30:16,960 --> 00:30:21,120
+ضمنها مجسمينها في اللوحتين هذول اللي معانا lung,
+
+391
+00:30:21,880 --> 00:30:25,780
+mouth, esophagus, intestinal tract طلعوا على ال
+
+392
+00:30:25,780 --> 00:30:30,980
+lung نيومونيا و tuberculosisلما بنقول aids، بنقول
+
+393
+00:30:30,980 --> 00:30:34,860
+tuberculosis لان، أسهل ناس ينصابوا بال
+
+394
+00:30:34,860 --> 00:30:39,000
+tuberculosis هم من مرضى ال aids و اللي بتسييرها
+
+395
+00:30:39,000 --> 00:30:41,240
+طبعا mycobacterium و tuberculosis طبعا ال
+
+396
+00:30:41,240 --> 00:30:45,840
+pneumonia فيبرازايت أو بالأحرى fungi اسمه
+
+397
+00:30:45,840 --> 00:30:49,480
+نيوموسيستس جيروفيسي أو نيوموسيستس كاريناي
+
+398
+00:30:49,480 --> 00:30:54,980
+نيوموسيستس كاريناي أو جيروفيسي اسم الجديد جيروفيسي
+
+399
+00:30:57,970 --> 00:31:01,350
+مرضى وما راشس مانع فيها انها بتسبب pneumonia عند
+
+400
+00:31:01,350 --> 00:31:05,190
+الأصحاء فقط عند مين؟ عند مرضى ال aids او عند دول
+
+401
+00:31:05,190 --> 00:31:10,930
+مناع المنقفضة تماماالـ Mouth in the thrush اللي هو
+
+402
+00:31:10,930 --> 00:31:14,150
+البيضاء تبع الفم وغالبا بتسببه Candida albicans
+
+403
+00:31:14,150 --> 00:31:19,470
+الخميرة المشهورة و ال Heri leukoplakia ودرسناها في
+
+404
+00:31:19,470 --> 00:31:23,590
+ال ابشتين بار فيروس و Ulceration ممكن caused by
+
+405
+00:31:23,590 --> 00:31:27,210
+herpes simplex virus و Histoplasma capsulatum و هي
+
+406
+00:31:27,210 --> 00:31:33,230
+خميرة ايضا تعتبر opportunistic pathogenالإيسوفاجوس
+
+407
+00:31:33,230 --> 00:31:37,870
+عاوز فيه انه thrush و caused by candida albicans
+
+408
+00:31:37,870 --> 00:31:42,030
+غالبا ال mouth و الإيسوفاجوس جراب من بعضها فممكن
+
+409
+00:31:42,030 --> 00:31:45,210
+يكون ال mouth فيه thrush و في نفس الوقت يكون فيه
+
+410
+00:31:45,210 --> 00:31:48,010
+في الإيسوفاجوس thrush caused by the same
+
+411
+00:31:48,010 --> 00:31:51,270
+microorganism اللي هو candida albicans و ال
+
+412
+00:31:51,270 --> 00:31:53,990
+candida albicans يا بنات في الفطريات انا بعلم
+
+413
+00:31:53,990 --> 00:31:59,450
+فطريات و طلبت الملستير بقولهم انه اهم عشرة اسباب
+
+414
+00:32:00,980 --> 00:32:07,320
+ليه؟ الأمراض الطفيلية هي Candida Candida Candida و
+
+415
+00:32:07,320 --> 00:32:12,260
+بعد لمن؟ لعند سبعة يعني أول يعني بتجيب جوه سبعين
+
+416
+00:32:12,260 --> 00:32:17,180
+بالمية من الأمراض اللي بتسببها الفطريات مرهونة
+
+417
+00:32:17,180 --> 00:32:20,180
+بمين؟ بال Candida ال .. بقى نسبة تلاتين بالمية
+
+418
+00:32:20,180 --> 00:32:24,800
+للأمراض الفطرية الأخرى طلعنا قبل فترة واجيزة خمية
+
+419
+00:32:24,800 --> 00:32:28,950
+دا اسمها Candida Orisفي الولايات المتحدة وفي بعض
+
+420
+00:32:28,950 --> 00:32:33,110
+الدول الأخرى و resistant لكل ال antifungal هي برضه
+
+421
+00:32:33,110 --> 00:32:36,090
+الخميرة مش بسيطة في الموضوع ال antimicrobial
+
+422
+00:32:36,090 --> 00:32:36,690
+resistance
+
+423
+00:32:40,670 --> 00:32:44,490
+دياريا و دياريا can be caused by several
+
+424
+00:32:44,490 --> 00:32:47,390
+microorganisms لكن كلكم بتعرفوا السيمون اللي هو
+
+425
+00:32:47,390 --> 00:32:50,990
+الشجر اللي عند الأصحى و غير الأصحى بتعمل infection
+
+426
+00:32:50,990 --> 00:32:53,890
+فعادي انه نجيها في مرضى ال aids هاللي عمره طبيعي
+
+427
+00:32:53,890 --> 00:32:57,890
+لكن اللي مش طبيعي اللي هو ال CMV انه يعمل دياريا
+
+428
+00:32:58,540 --> 00:33:01,420
+عند المرضى الـ AIDS اللى مش طبيعى انه يجى لـ
+
+429
+00:33:01,420 --> 00:33:06,520
+Cryptococcus او Cryptosporidium Parvum و هي
+
+430
+00:33:06,520 --> 00:33:10,960
+برازايت ايضا لا يسبب اسهال بشكل كبير الا عند
+
+431
+00:33:10,960 --> 00:33:15,380
+الاطفال او عند دو المناعة المنخفضة بالاضافة الى
+
+432
+00:33:15,380 --> 00:33:19,500
+الـGuardia Lamblia طبعا الـGuardia Lamblia واحدة
+
+433
+00:33:19,500 --> 00:33:22,940
+من اشهر ال pathogens اللى موجودة عندنا في غزة هي
+
+434
+00:33:22,940 --> 00:33:26,380
+الانتميبة استيلوتيكا وهي صديقة الدكتور عبدالله
+
+435
+00:33:26,380 --> 00:33:31,150
+الهنديلأنه دايما بيعمل دراسات على الأطفال في
+
+436
+00:33:31,150 --> 00:33:34,330
+مستوات مختلفة في أماكن مختلفة والحمد لله يا رب
+
+437
+00:33:34,330 --> 00:33:37,930
+العالمين يعني بدأ الأرقام تبعتها تنزل في السنوات
+
+438
+00:33:37,930 --> 00:33:42,810
+الأخيرة نتيجة اللي هو وجود التحسن في مستوى البني
+
+439
+00:33:42,810 --> 00:33:48,210
+التحتية للمياه العاديةالـ central nervous system
+
+440
+00:33:48,210 --> 00:33:51,230
+زي الـ meningitis، الـ brain abscesses و
+
+441
+00:33:51,230 --> 00:33:54,870
+progressive multifocal leukoencephalopathy اللي
+
+442
+00:33:54,870 --> 00:33:58,490
+بسببه فيروس اسمه GC virus و الـ brain abscess
+
+443
+00:33:58,490 --> 00:34:03,870
+تخيلوا الـ Toxoplasma Gundai اللي هي الـالمشهورة
+
+444
+00:34:03,870 --> 00:34:06,850
+بالجرثومة عندنا في فلسطين واللي مرتبطة بمين
+
+445
+00:34:06,850 --> 00:34:12,950
+بالاجهاد مرتبطة بالقطط لكن طبان الأفاضل يعني نشروا
+
+446
+00:34:12,950 --> 00:34:16,550
+ثقافة بأن معظم حالات الإجهاد كانت من مين من
+
+447
+00:34:16,550 --> 00:34:21,530
+الجرثومة والأسف هذا يعني كان اعتقاد خاطئ ومرروا
+
+448
+00:34:21,530 --> 00:34:26,110
+للناس فأهملوا الأسباب الحقيقية للاجهاد في أنه
+
+449
+00:34:26,110 --> 00:34:29,130
+موجود عندهم toxoplasmosis شوفوا الرقم اللي
+
+450
+00:34:29,130 --> 00:34:34,490
+بيحكيلكوا يا بناتمن كل عشرة ألاف امرأة حامل والان
+
+451
+00:34:34,490 --> 00:34:40,930
+حامل والان أصيبت بالـ Toxoplasmosis احتمالية
+
+452
+00:34:40,930 --> 00:34:45,760
+الإجهاد واحدة من عشرة ألافيعني اللى اللى اللى اللى
+
+453
+00:34:45,760 --> 00:34:46,320
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+454
+00:34:46,320 --> 00:34:48,260
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+455
+00:34:48,260 --> 00:34:49,120
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+456
+00:34:49,120 --> 00:34:49,680
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+457
+00:34:49,680 --> 00:34:52,560
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+458
+00:34:52,560 --> 00:34:52,620
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+459
+00:34:52,620 --> 00:34:52,720
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+460
+00:34:52,720 --> 00:34:53,100
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+461
+00:34:53,100 --> 00:35:02,020
+اللى اللى اللى اللى اللى اللى اللى
+
+462
+00:35:07,450 --> 00:35:10,730
+عندها Erythema اللي هي الـ Toxoplasma Gondii هذا
+
+463
+00:35:10,730 --> 00:35:17,990
+الطفل 99% و 9 من 10 يمكن ال infection تبقى
+
+464
+00:35:17,990 --> 00:35:22,470
+asymptomatic لكن عند مرض ال aids ايش هيعملها؟
+
+465
+00:35:22,470 --> 00:35:29,590
+brain abscess إذا كان هذا مرض بشكل خطوري في حد
+
+466
+00:35:29,590 --> 00:35:32,030
+لطيف عن ال Toxoplasma لازم أحكيلكوا إياها
+
+467
+00:35:34,890 --> 00:35:42,110
+التوكسو بلازمة طفيل برازايت لا يفقه يعني ماعندوش
+
+468
+00:35:42,110 --> 00:35:46,970
+ذكاء كبير أو هيك بنعتقد احنا لكن اتطلع و جديش
+
+469
+00:35:46,970 --> 00:35:49,970
+الذكاء تبعه هذا ال life cycle تبعه انت قلتي وين
+
+470
+00:35:49,970 --> 00:35:54,890
+قطعت لكن جزء من ال life cycle تبعه الفقران اول ما
+
+471
+00:35:54,890 --> 00:35:58,730
+بصيب بصيب الفقران و اين بصيبها في دماغها بصيب تحب
+
+472
+00:35:58,730 --> 00:36:04,410
+البسسالفقران اللي مشهور عنها فهو هذا من ال .. من
+
+473
+00:36:04,410 --> 00:36:10,890
+اللي بيسموه brain modulating parasites يعني طفليات
+
+474
+00:36:10,890 --> 00:36:17,510
+تعدل من سلوك الدماغ تمام؟ فبيخلي الفقران ترغب
+
+475
+00:36:17,510 --> 00:36:21,730
+الذهاب إلى القطط ليش؟ عشان تاكلها طبعا ال farm مش
+
+476
+00:36:21,730 --> 00:36:25,710
+الذهاب مش المسكين تحت تأثير مين؟ تحت تأثير التكسو
+
+477
+00:36:25,710 --> 00:36:31,090
+بلازموز عشان هو يكمل ال life cycleطبعا كمان في شغل
+
+478
+00:36:31,090 --> 00:36:34,430
+لجوها مهمة ان الناس اللي بيعمل حوايات السيارات
+
+479
+00:36:34,430 --> 00:36:40,630
+اللي عندهم antibody لtoxoplasmosis اكثر من اللي
+
+480
+00:36:40,630 --> 00:36:44,710
+ماعندهمش بمعنى انه قد يكون سبب من سبب حوايات
+
+481
+00:36:44,710 --> 00:36:47,210
+السيارات ان يكون عند الإنسان ايه؟ toxoplasmosis،
+
+482
+00:36:47,210 --> 00:36:52,560
+ماعرفي ليش؟ بقولك بيأخر ردة الفعلمتعرفين بين حادث
+
+483
+00:36:52,560 --> 00:36:57,900
+عالم الحادث ملي ساكنز ان هي تاخد قرار تضرب break
+
+484
+00:36:57,900 --> 00:37:02,580
+او ماضربش break صح؟ فبالتالي وجود تكسب لازمة في
+
+485
+00:37:02,580 --> 00:37:07,240
+أدمغة البشر قد يعيق اللي هي ردة الفعل هذه فقط
+
+486
+00:37:07,240 --> 00:37:13,090
+للسبب في الحوادث، اذا هذا مموذج على برازايفمن خلق
+
+487
+00:37:13,090 --> 00:37:17,270
+الله سبحانه وتعالى يعني اللي له هذه القدرة العالية
+
+488
+00:37:17,270 --> 00:37:22,250
+في التحكم في الأدمغة خل الفقران تتخلى عن عداءه
+
+489
+00:37:22,250 --> 00:37:26,530
+التاريخي للقطط في سبيل انه يعمل ال life cycle تبعه
+
+490
+00:37:27,610 --> 00:37:32,230
+الـ I-Retinitis can be caused by CMV طبعا CMV نجم
+
+491
+00:37:32,230 --> 00:37:37,070
+من نجوم الـ HIV يعني من اللي بسبب أمرها عند مرضى
+
+492
+00:37:37,070 --> 00:37:40,770
+ال AIDS الكابوس الساركومة في ال skin كلكم بتعرفوها
+
+493
+00:37:40,770 --> 00:37:45,190
+الـ HHV8 اللي هو ال human herpes virus type 8
+
+494
+00:37:45,190 --> 00:37:48,870
+والزوستر Varicella zooster بالضعف إلى اللي هو
+
+495
+00:37:48,870 --> 00:37:51,850
+subcutaneous nodules caused by Cryptococcus
+
+496
+00:37:51,850 --> 00:37:56,890
+neiformis واللي Cryptococcus ذكرناها في أكتر مكان
+
+497
+00:37:57,060 --> 00:38:01,520
+وهي من مسببات بالمناسبة التهاب الصحي كريبت كوكاس
+
+498
+00:38:01,520 --> 00:38:05,140
+نيو فومس المرة الجاية ان شاء الله بنكمل بإذن الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..a2604fc7e5b9ca234cde65dddb67629857a4ccd1
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Qo7RymXpGFE_raw.json
@@ -0,0 +1 @@
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إن الفترة ما بين دخول الفيروس و بين ظهور الأعراض للـ HIV تتراوح لكن هي في الآخر طويلة هي فترة طويلة غالبا بقى بتكون أطول لما يكون المسبب بالـ AIDS هو HIV-9 يعني الفترة الـ incubation بتكون مالها أطول من HIV-1 الشكل اللي أمامنا هو الشكل الجميل لهذا الفيروس", "tokens": [3555, 6027, 1863, 35457, 3660, 24976, 39184, 15907, 12, 16, 8717, 5016, 1863, 8717, 3615, 28480, 36145, 27188, 2655, 25720, 19446, 49374, 11778, 9778, 12610, 27188, 13546, 41779, 4032, 49374, 1357, 116, 3224, 13063, 16247, 3615, 2288, 46958, 24976, 39184, 15907, 6055, 2655, 23557, 2407, 5016, 44381, 39896, 8978, 6024, 95, 34740, 23032, 2407, 26895, 3660, 39896, 6156, 2655, 25720, 23032, 2407, 26895, 3660, 32771, 6027, 3555, 995, 4724, 4587, 7578, 39894, 30544, 5551, 9566, 12610, 5296, 15042, 7251, 30544, 9673, 35457, 3555, 20666, 39184, 27929, 31439, 15907, 12, 24, 37495, 22653, 27188, 2655, 25720, 2423, 39184, 33345, 399, 39894, 30544, 3714, 6027, 11296, 5551, 9566, 12610, 9154, 15907, 12, 16, 25124, 28820, 13672, 1829, 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double genome بيعطينا إي حق مين بال retro virus و خاصة لما نشوف منه انه جدتين الحمر هدولة اللي ماشي هدولة هدولة معبرة عن الانزيم الاسمه reverse transcriptase طبعا فينا envelope و فينا ال matrix و فينا ال core في هذا ال particle التوضيحية", "tokens": [9566, 3555, 3615, 995, 15844, 23032, 12610, 19446, 11331, 3215, 2288, 44945, 8592, 38688, 1975, 5016, 8315, 3834, 21953, 4724, 1829, 3615, 9566, 1829, 8315, 11933, 1829, 11331, 4587, 3714, 9957, 20666, 18820, 5752, 4032, 16490, 33546, 3660, 5296, 15042, 8717, 8592, 38688, 9154, 3224, 16472, 3224, 10874, 3215, 2655, 9957, 21542, 29973, 8032, 3215, 12610, 3660, 13672, 1829, 3714, 33599, 1829, 8032, 3215, 12610, 3660, 8032, 3215, 12610, 3660, 20449, 3555, 25720, 18871, 2423, 7649, 11622, 32640, 2423, 32277, 2304, 3224, 9943, 24444, 651, 23032, 3555, 3615, 995, 8978, 8315, 19989, 4032, 8978, 8315, 2423, 8141, 4032, 8978, 8315, 2423, 4965, 8978, 23758, 2423, 12359, 16712, 2407, 11242, 1829, 5016, 10632], "avg_logprob": -0.2961836283185841, 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"text": "و بعدين بيصير في عملية طبعا في جزء من ال life cycle مفقود هنا هو انه جزء من ال من ال core تبع ال virus بقعد بيرجع لمين؟ بيرجع للنواة بيصير له maturation وبعدين بطلع إلى الخارج طبعا الخروج عن طريق اللي وجودنا ال budding وفي ال budding بياخد ال spikes تبعته اللي من ضمنها ال GP120 وال GP41", "tokens": [2407, 39182, 9957, 4724, 1829, 9381, 13546, 8978, 6225, 42213, 10632, 23032, 3555, 3615, 995, 8978, 10874, 11622, 38207, 9154, 2423, 993, 6586, 3714, 5172, 4587, 23328, 34105, 31439, 16472, 3224, 10874, 11622, 38207, 9154, 2423, 9154, 2423, 4965, 6055, 3555, 3615, 2423, 5752, 4724, 4587, 22488, 4724, 13546, 7435, 3615, 5296, 2304, 9957, 22807, 4724, 13546, 7435, 3615, 24976, 1863, 14407, 3660, 4724, 1829, 9381, 13546, 46740, 3803, 8167, 46599, 22488, 9957, 4724, 9566, 1211, 3615, 30731, 33962, 9640, 7435, 23032, 3555, 3615, 995, 33962, 2288, 29245, 18871, 23032, 16572, 4587, 13672, 1829, 49610, 23328, 8315, 2423, 3265, 3584, 4032, 41185, 2423, 3265, 3584, 4724, 1829, 47283, 3215, 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0.9677734375}, {"start": 2250.33, "end": 2250.73, "word": " CMV", "probability": 0.6766357421875}, {"start": 2250.73, "end": 2251.01, "word": " طبعا", "probability": 0.8729248046875}, {"start": 2251.01, "end": 2251.57, "word": " CMV", "probability": 0.63818359375}, {"start": 2251.57, "end": 2252.23, "word": " نجم", "probability": 0.9498697916666666}, {"start": 2252.23, "end": 2252.37, "word": " من", "probability": 0.97216796875}, {"start": 2252.37, "end": 2252.85, "word": " نجوم", "probability": 0.9444986979166666}, {"start": 2252.85, "end": 2253.39, "word": " الـ", "probability": 0.887939453125}, {"start": 2253.39, "end": 2253.75, "word": " HIV", "probability": 0.61181640625}, {"start": 2253.75, "end": 2254.59, "word": " يعني", "probability": 0.868408203125}, {"start": 2254.59, "end": 2254.77, "word": " من", "probability": 0.75634765625}, {"start": 2254.77, "end": 2255.57, "word": " اللي", "probability": 0.803955078125}, {"start": 2255.57, "end": 2255.97, "word": " بسبب", "probability": 0.8575846354166666}, {"start": 2255.97, "end": 2256.29, "word": " أمرها", "probability": 0.706298828125}, {"start": 2256.29, "end": 2256.55, "word": " عند", "probability": 0.42138671875}, {"start": 2256.55, "end": 2257.07, "word": " مرضى", "probability": 0.9661458333333334}, {"start": 2257.07, "end": 2257.23, "word": " ال", "probability": 0.9638671875}, {"start": 2257.23, "end": 2257.45, "word": " AIDS", "probability": 0.6845703125}, {"start": 2257.45, "end": 2258.79, "word": " الكابوس", "probability": 0.76220703125}, {"start": 2258.79, "end": 2259.29, "word": " الساركومة", "probability": 0.659033203125}, {"start": 2259.29, "end": 2259.39, "word": " في", "probability": 0.92333984375}, {"start": 2259.39, "end": 2259.49, "word": " ال", "probability": 0.93701171875}, {"start": 2259.49, "end": 2259.81, "word": " skin", "probability": 0.7822265625}, {"start": 2259.81, "end": 2260.21, "word": " كلكم", "probability": 0.6343587239583334}, {"start": 2260.21, "end": 2260.77, "word": " بتعرفوها", "probability": 0.91904296875}, {"start": 2260.77, "end": 2261.41, "word": " الـ", "probability": 0.828125}, {"start": 2261.41, "end": 2263.31, "word": " HHV8", "probability": 0.83740234375}, {"start": 2263.31, "end": 2263.51, "word": " اللي", "probability": 0.916259765625}, {"start": 2263.51, "end": 2263.63, "word": " هو", "probability": 0.984375}, {"start": 2263.63, "end": 2263.75, "word": " ال", "probability": 0.9130859375}, {"start": 2263.75, "end": 2263.91, "word": " human", "probability": 0.490478515625}, {"start": 2263.91, "end": 2264.29, "word": " herpes", "probability": 0.7135009765625}, {"start": 2264.29, "end": 2264.59, "word": " virus", "probability": 0.90966796875}, {"start": 2264.59, "end": 2264.87, "word": " type", "probability": 0.94091796875}, {"start": 2264.87, "end": 2265.19, "word": " 8", "probability": 0.544921875}, {"start": 2265.19, "end": 2266.19, "word": " والزوستر", "probability": 0.722998046875}, {"start": 2266.19, "end": 2266.65, "word": " Varicella", "probability": 0.4636637369791667}, {"start": 2266.65, "end": 2267.09, "word": " zooster", "probability": 0.54986572265625}, {"start": 2267.09, "end": 2267.89, "word": " بالضعف", "probability": 0.75445556640625}, {"start": 2267.89, "end": 2268.09, "word": " إلى", "probability": 0.85986328125}, {"start": 2268.09, "end": 2268.71, "word": " اللي", "probability": 0.972412109375}, {"start": 2268.71, "end": 2268.87, "word": " هو", "probability": 0.986328125}, {"start": 2268.87, "end": 2269.55, "word": " subcutaneous", "probability": 0.8653971354166666}, {"start": 2269.55, "end": 2270.09, "word": " nodules", "probability": 0.900146484375}, {"start": 2270.09, "end": 2270.41, "word": " caused", "probability": 0.892578125}, {"start": 2270.41, "end": 2270.79, "word": " by", "probability": 0.97314453125}, {"start": 2270.79, "end": 2271.85, "word": " Cryptococcus", "probability": 0.8758544921875}, {"start": 2271.85, "end": 2272.95, "word": " neiformis", "probability": 0.6666666666666666}, {"start": 2272.95, "end": 2273.43, "word": " واللي", "probability": 0.527587890625}, {"start": 2273.43, "end": 2273.95, "word": " Cryptococcus", "probability": 0.9161376953125}, {"start": 2273.95, "end": 2275.85, "word": " ذكرناها", "probability": 0.9598388671875}, {"start": 2275.85, "end": 2276.19, "word": " في", "probability": 0.982421875}, {"start": 2276.19, "end": 2276.47, "word": " أكتر", "probability": 0.963134765625}, {"start": 2276.47, "end": 2276.89, "word": " مكان", "probability": 0.752197265625}], "temperature": 1.0}, {"id": 99, "seek": 228514, "start": 2277.06, "end": 2285.14, "text": "وهي من مسببات بالمناسبة التهاب الصحي كريبت كوكاس نيو فومس المرة الجاية ان شاء الله بنكمل بإذن الله", "tokens": [2407, 3224, 1829, 9154, 3714, 35457, 3555, 9307, 20666, 2304, 8315, 35457, 3660, 16712, 11296, 3555, 31767, 5016, 1829, 9122, 16572, 3555, 2655, 9122, 2407, 4117, 32277, 8717, 1829, 2407, 6156, 20498, 3794, 9673, 25720, 25724, 995, 10632, 16472, 13412, 16606, 21984, 44945, 24793, 1211, 4724, 28814, 8848, 1863, 21984], "avg_logprob": -0.27910538163839604, "compression_ratio": 1.5982142857142858, "no_speech_prob": 0.0, "words": [{"start": 2277.06, "end": 2277.68, "word": "وهي", "probability": 0.8896484375}, {"start": 2277.68, "end": 2277.82, "word": " من", "probability": 0.95068359375}, {"start": 2277.82, "end": 2278.54, "word": " مسببات", "probability": 0.81927490234375}, {"start": 2278.54, "end": 2279.36, "word": " بالمناسبة", "probability": 0.93857421875}, {"start": 2279.36, "end": 2280.16, "word": " التهاب", "probability": 0.8948567708333334}, {"start": 2280.16, "end": 2280.72, "word": " الصحي", "probability": 0.7255045572916666}, {"start": 2280.72, "end": 2281.04, "word": " كريبت", "probability": 0.724884033203125}, {"start": 2281.04, "end": 2281.52, "word": " كوكاس", "probability": 0.7579345703125}, {"start": 2281.52, "end": 2282.26, "word": " نيو", "probability": 0.6099446614583334}, {"start": 2282.26, "end": 2282.82, "word": " فومس", "probability": 0.5293782552083334}, {"start": 2282.82, "end": 2283.1, "word": " المرة", "probability": 0.897705078125}, {"start": 2283.1, "end": 2283.3, "word": " الجاية", "probability": 0.6078287760416666}, {"start": 2283.3, "end": 2283.38, "word": " ان", "probability": 0.7080078125}, {"start": 2283.38, "end": 2283.6, "word": " شاء", "probability": 0.983154296875}, {"start": 2283.6, "end": 2283.84, "word": " الله", "probability": 0.9541015625}, {"start": 2283.84, "end": 2284.68, "word": " بنكمل", "probability": 0.8981119791666666}, {"start": 2284.68, "end": 2284.98, "word": " بإذن", "probability": 0.851806640625}, {"start": 2284.98, "end": 2285.14, "word": " الله", "probability": 0.962890625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2285.4240625, "duration_after_vad": 2189.0924999999934}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/QvUu9hWKCrM.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/QvUu9hWKCrM.srt
new file mode 100644
index 0000000000000000000000000000000000000000..9ba03901ce40533799ef2a5f8537f5fdd819a27e
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/QvUu9hWKCrM.srt
@@ -0,0 +1,1943 @@
+1
+00:00:21,090 --> 00:00:23,630
+بسم الله الرحمن الرحيم، الحمد لله رب العالمين
+
+2
+00:00:23,630 --> 00:00:30,330
+ضِمن فيروسين في المجموعة، الـ rabies أحدهما، نبدأ بالـ
+
+3
+00:00:30,330 --> 00:00:36,190
+rabies اللي يمكن أن يصنف على أنه الفيروس الأكثر
+
+4
+00:00:36,190 --> 00:00:40,930
+فتكا أو الأكثر قدرة على القتل في العالم، ليش؟ لأن كلّ
+
+5
+00:00:40,930 --> 00:00:45,770
+الحالات التي لا تُعالج من هذا الفيروس تنتهي بالموت
+
+6
+00:00:46,250 --> 00:00:50,470
+يعني ما فيش نسبة شفاء أو نسبة وفيات معينة بنقول
+
+7
+00:00:50,470 --> 00:00:55,010
+hundred percent fatality rate if untreated، إذن
+
+8
+00:00:55,010 --> 00:00:58,650
+هذا فيروس من أخطر الفيروسات على وجه
+
+9
+00:00:58,650 --> 00:01:05,180
+الأرض، اللي بيخلينا ما نهتمش فيه كثير، إنه عارض 
+
+10
+00:01:05,180 --> 00:01:08,180
+للحالات اللي موجودة أو ناتج عنها الإصابة به قليلة
+
+11
+00:01:08,180 --> 00:01:11,320
+جدا، يعني في الفترة السابقة لم نسمع بالإصابة بهذا
+
+12
+00:01:11,320 --> 00:01:14,200
+الفيروس من سنوات عديدة، الولايات المتحدة في العام
+
+13
+00:01:14,200 --> 00:01:19,580
+2007 أعلنت أنها خالية من الـ rabies اللي بسبب 
+
+14
+00:01:19,580 --> 00:01:24,340
+الكلاب، أعلنتها خالية من الـ rabies من نوع ثاني، هتكلم عنه لكن 
+
+15
+00:01:24,340 --> 00:01:28,720
+بسبب الكلاب انتهى الـ rabies، على حالات الـ rabies في
+
+16
+00:01:28,720 --> 00:01:33,020
+العالم كله سنويًا لا تتجاوز الـ 50 ألف حالة، طبعًا
+
+17
+00:01:33,020 --> 00:01:36,460
+كلمة 50 ألف على مستوى سكان العالم هذا رقم إيه؟
+
+18
+00:01:36,460 --> 00:01:38,980
+يعني اللي بيموت من الاختناق و بيأكل و بيشرب
+
+19
+00:01:38,980 --> 00:01:43,500
+يمكن أكثر من 50 ألف، لذا الرقم بيكون هذا رقم ضئيل
+
+20
+00:01:43,500 --> 00:01:47,140
+طبعًا هنقول اللي احنا ليش هو قلّ و ليش فيه صار تغيير
+
+21
+00:01:47,140 --> 00:01:49,620
+في الـ epidemiology، إذا احنا هالمرة حكينا المحاضرة
+
+22
+00:01:49,620 --> 00:01:51,340
+السابقة قد كلمنا عن التغيير في الـ epidemiology
+
+23
+00:01:51,340 --> 00:01:56,360
+لهذا الفيروس، المعرض اسمه Rabies، الفيروس من عائلة
+
+24
+00:01:56,360 --> 00:02:01,740
+اسمها Rabdovirus وهو الوحيد من هذه العائلة اللي له
+
+25
+00:02:01,740 --> 00:02:05,780
+أهمية طبية، الباقين موجودين فيه أفراد آخرين لكن ليس
+
+26
+00:02:05,780 --> 00:02:10,400
+لهم أهمية طبية، بيحتوي على single-stranded RNA
+
+27
+00:02:10,400 --> 00:02:15,740
+enclosed .. housed by a bullet shape اللي هي الـ
+
+28
+00:02:15,740 --> 00:02:18,960
+capsid اللي شكل الرصاصة، surrounded by a
+
+29
+00:02:18,960 --> 00:02:22,080
+lipoprotein envelope، و أنا اتفقنا إنه هو helical
+
+30
+00:02:22,080 --> 00:02:27,080
+سمتري، وبالتالي كلّ helical اصلا envelope virus
+
+31
+00:02:28,040 --> 00:02:32,880
+الجنوم نيجاتيف سنس وبالتالي يجب أن يحمل على RNA
+
+32
+00:02:32,880 --> 00:02:37,480
+dependent RNA polymerase، ريبز فيروس has a single
+
+33
+00:02:37,480 --> 00:02:43,080
+antigenic type only one zero type، يعني stable الـ
+
+34
+00:02:43,080 --> 00:02:46,820
+Antigenicity ناتجة عن الـ Spikes اللي موجودة على
+
+35
+00:02:46,820 --> 00:02:50,780
+الـ Glycoprotein زي باقي المجموعة اللي درسناهم
+
+36
+00:02:50,780 --> 00:02:54,360
+تمام؟ بس ما تخصصناش، ما قلناش هو Hemagglutinin ولا
+
+37
+00:02:54,360 --> 00:02:57,980
+الـ Neuraminidase، تمام؟ هو Spikes من نوع خاص، لكن
+
+38
+00:02:57,980 --> 00:03:03,740
+الـ Immunity الناتجة هي ضد هذا الـ Antigen اللي
+
+39
+00:03:03,740 --> 00:03:08,140
+موجود على الـ Spike، هنا الميزة اللي بتميّز فيها ده
+
+40
+00:03:08,140 --> 00:03:12,160
+الفيروس، it has a very broad range of hosts، يعني
+
+41
+00:03:12,160 --> 00:03:15,400
+بيصيب الـ rabies اللي كنا نقول الإنسان الإنفلوانزا
+
+42
+00:03:15,400 --> 00:03:20,520
+الإنسان والخنزير والحصان والطيور، البعوض الإنفلوانزا
+
+43
+00:03:20,520 --> 00:03:24,000
+الإنسان وشوية حيوانات، بعض الأوضاع الأخرى موظف ما
+
+44
+00:03:24,000 --> 00:03:28,970
+كانت لمين فقط؟ ده الإنسان، بس هذا كلّ الـ mammals
+
+45
+00:03:28,970 --> 00:03:33,950
+تقريبًا يمكن أن تصاب، مين بيجيب يفسر لي ليش؟ و ياخد
+
+46
+00:03:33,950 --> 00:03:41,790
+26 على الـ .. على الفصل وعلى العلامة تبعتهم؟ إيش
+
+47
+00:03:41,790 --> 00:03:45,070
+هو الـ receptor؟ طب لمن يعطي اللي على العلامة هنا يا
+
+48
+00:03:45,070 --> 00:03:50,940
+عزيزي؟ بالنص، خلاص، لأن الـ Receptor تبعه هو الـ
+
+49
+00:03:50,940 --> 00:03:54,600
+acetylcholine، و الـ acetylcholine موجود في كلّ
+
+50
+00:03:54,600 --> 00:03:58,000
+الـ mammals، و بالتالي بالفعل يمكن، لكن من بين هذه
+
+51
+00:03:58,000 --> 00:04:01,820
+الـ mammals شوية mammals اللي ممكن تنقله للإنسان و
+
+52
+00:04:01,820 --> 00:04:07,940
+تكون ريزرفوار لهذا المرض، العضة من الـ rabid animal، و
+
+53
+00:04:07,940 --> 00:04:10,820
+كلمة rabid animal يعني حيوان مصاب بالـ rabies أو
+
+54
+00:04:10,820 --> 00:04:14,620
+بداء الكلب، that manifests aggressive الذي يظهر
+
+55
+00:04:14,620 --> 00:04:19,850
+aggressive عدوانية، biting behavior induced by the
+
+56
+00:04:19,850 --> 00:04:24,270
+viral encephalitis اللي بيخلي الحيوان يظهر هذه
+
+57
+00:04:24,270 --> 00:04:28,650
+العدوانية ليست طبيعة هذا الحيوان العادية وإنما
+
+58
+00:04:28,650 --> 00:04:32,990
+إصابته بـ encephalitis، يعني نقدر نقول إنه من الضغط
+
+59
+00:04:32,990 --> 00:04:35,530
+اللي موجود في الدماغ ومن الألم اللي موجود في
+
+60
+00:04:35,530 --> 00:04:39,710
+الدماغ بيفقد الحيوان قدرته على التمييز أو أن يكون
+
+61
+00:04:39,710 --> 00:04:42,490
+على طبيعته، بيتصرف بعدوانية كبيرة
+
+62
+00:04:46,380 --> 00:04:52,000
+في الولايات المتحدة معظم حالات الـ rabies بتتم من
+
+63
+00:04:52,000 --> 00:04:54,820
+خلال الـ wild animal، الآن كنت مميز بين كلمة wild
+
+64
+00:04:54,820 --> 00:04:58,360
+animal وبين domestic animals، الآن الكلاب و
+
+65
+00:04:58,360 --> 00:05:01,880
+القطط في أوروبا وأمريكا هي domestic animals
+
+66
+00:05:01,880 --> 00:05:05,800
+مظبوط؟ و الـ .. الـ .. الـ raccoon، عشان المثال
+
+67
+00:05:05,800 --> 00:05:08,660
+الـ raccoon اللي هو الحيوانة اللطيفة اللي له ذيل
+
+68
+00:05:08,660 --> 00:05:11,960
+طويل مقطع حلقات هيك، دي لونه أسود، هنشوف صورة له
+
+69
+00:05:11,960 --> 00:05:16,370
+كمان شوية، و في حاجة اسمها skunk، skunk اللي هو
+
+70
+00:05:16,370 --> 00:05:23,970
+الظربان، برضه حيوان شكله جميل لكن يطلق رائحة كريهة
+
+71
+00:05:23,970 --> 00:05:27,850
+كنوع من اللي هو الدفاع عن النفس، وعنده شجاعة
+
+72
+00:05:27,850 --> 00:05:32,210
+مقاطعة النظر هذا الحيوان، يعني بيدخل على بيوت
+
+73
+00:05:32,210 --> 00:05:36,290
+الناس، ما بيهتم لأي مخلوقات حتى لو شاف أسد قدامه
+
+74
+00:05:36,290 --> 00:05:40,910
+ما بتفرق معاه، هذا اللي هو الـ skunk، Raccoons and
+
+75
+00:05:40,910 --> 00:05:45,590
+bats هذي هي الأكثر .. خلّيني أقول في الولايات
+
+76
+00:05:45,590 --> 00:05:51,030
+المتحدة الأكثر إحداثًا للـ rabies، Dogs and cats are
+
+77
+00:05:51,030 --> 00:05:53,950
+frequently immunized and therefore are rarely
+
+78
+00:05:53,950 --> 00:05:57,110
+sources of human infection، في السنوات الأخيرة
+
+79
+00:05:57,110 --> 00:06:03,030
+الخفافيش أصبحت مصدر لمعظم حالات الـ human rabies في
+
+80
+00:06:03,030 --> 00:06:08,370
+الولايات المتحدة، ملاحظة القوارض والأرانب لا تقوم
+
+81
+00:06:08,370 --> 00:06:14,510
+بنقل اللي هو هذا المرض، في نقطة كثير مهمة الـ bats
+
+82
+00:06:14,510 --> 00:06:19,660
+أو الخفافيش ليس بالضرورة يا بنات أنها تعدّلكن هي
+
+83
+00:06:19,660 --> 00:06:24,560
+بتطير، وهنشوف نقطة كثير مهمة في هذا الفيروس إنه
+
+84
+00:06:24,560 --> 00:06:28,720
+أوكي، هو بيتكاثر في مكان العضة اللي هو في الجلد وفي
+
+85
+00:06:28,720 --> 00:06:32,340
+الـ nerve وبعدين بيطلع على الـ central nervous
+
+86
+00:06:32,340 --> 00:06:37,280
+system، بيضل يمشي لما يصل لـ salivary gland، بيروح على
+
+87
+00:06:37,280 --> 00:06:40,780
+الـ salivary gland وهناك بيعمل induction للـ
+
+88
+00:06:40,780 --> 00:06:43,720
+salivation، الـ salivation اللي هو اللعاب، ليش بيعمل
+
+89
+00:06:43,720 --> 00:06:46,480
+induction للـ salivation؟ عشان الفيروس يصير له
+
+90
+00:06:46,480 --> 00:06:50,240
+secretion مع اللي هو أو عفوا الفيروس يكون مع الـ
+
+91
+00:06:50,240 --> 00:06:54,660
+secretions، عشان لما يهض، أظن يهض من الفم اللي وين
+
+92
+00:06:54,660 --> 00:06:58,640
+فيه اللعاب، ففرصته في الانتقال للآخرين بتكون مالها
+
+93
+00:06:58,640 --> 00:07:05,730
+بتكون أعلى، الآن الخفافيش بتهضّ لكن وهي طايرة الـ
+
+94
+00:07:05,730 --> 00:07:09,370
+saliva تبعتها أو الـ secretions ممكن تطير كردّ فعل
+
+95
+00:07:09,370 --> 00:07:14,330
+وتصل إلى جروح أو تصل عبر الأنف، يعني في تدخل إلى
+
+96
+00:07:14,330 --> 00:07:18,810
+جسم الإنسان، هنا المشكلة الكبيرة اللي بتعرّض لـ
+
+97
+00:07:18,810 --> 00:07:24,330
+animal bite بيروح بيزور الطبيب، بس واحد ما تعرض لـ
+
+98
+00:07:24,330 --> 00:07:29,000
+animal bite ليش يزور الطبيب؟ و للأسف الحالات اللي
+
+99
+00:07:29,000 --> 00:07:32,900
+تنتقل عن طريق الخفافيش لا يمكن تشخيصها إلا بعد
+
+100
+00:07:32,900 --> 00:07:37,780
+ظهور الأعراض، وإذا ظهرت الأعراض على هذا المرض أو
+
+101
+00:07:37,780 --> 00:07:42,120
+بهذا المرض غالبًا نسبة الوفيات كمان مرة بتصل إلى
+
+102
+00:07:42,120 --> 00:07:46,340
+100%، طبعًا مع تطور اللي حصل في موضوع الـ life
+
+103
+00:07:46,340 --> 00:07:49,200
+supporting machines اللي هي الأجهزة، أجهزة التنفس
+
+104
+00:07:49,200 --> 00:07:53,580
+صناعية وخلافه، في بعض الحالات survived لكن النسبة
+
+105
+00:07:53,580 --> 00:07:59,350
+الأعظم كمان مرة، إذا الخفافيش ممكن تنقل إلينا اللي
+
+106
+00:07:59,350 --> 00:08:04,470
+هو الـ rabies من خلال الـ secretions والـ saliva
+
+107
+00:08:04,470 --> 00:08:05,190
+تبعتها
+
+108
+00:08:08,140 --> 00:08:10,720
+هي بعض الصور، هذا الـ skunk اللي حكينا عنه اللي هو
+
+109
+00:08:10,720 --> 00:08:14,040
+الظربان، وهذا الـ raccoon شايفين الحلقات اللي في الذيل
+
+110
+00:08:14,040 --> 00:08:17,440
+اللي طبعته؟ تمام؟ وطبعًا الخفافيش ما هو أشكال
+
+111
+00:08:17,440 --> 00:08:21,540
+وأنواع كثيرة ومتنوعة، في منها حجم يعني صغير خالص
+
+112
+00:08:21,540 --> 00:08:27,160
+وفي حجم يعني بيأكلوه في بعض القبائل الأفريقية، طبعًا
+
+113
+00:08:27,160 --> 00:08:30,000
+شوفوا القطة هذا اللي مطلع عنا كلّها لعاب من الـ
+
+114
+00:08:30,000 --> 00:08:33,440
+saliva، هذا الكلب rabid dog برضه بيطلع كمية كبيرة
+
+115
+00:08:33,440 --> 00:08:39,250
+من إيه؟ من الـ saliva، دلالة على إنه الفيروس وصل الـ
+
+116
+00:08:39,250 --> 00:08:42,390
+salivary gland وعمل induction لمن؟ للـ salivation
+
+117
+00:08:42,390 --> 00:08:47,030
+كوسيلة للـ cycle تبعته إنه ينتقل لآخرين
+
+118
+00:08:49,620 --> 00:08:53,520
+Another rare example of transmission .. ذكرنا بعض
+
+119
+00:08:53,520 --> 00:08:57,000
+الحيوانات، و ذكرنا الـ bats، مظبوط، واحد من الأمثلة
+
+120
+00:08:57,000 --> 00:09:03,900
+النادرة نقل قرنية عين من متوفاة لأسباب غير معروفة
+
+121
+00:09:03,900 --> 00:09:07,980
+واحد ميت، تمام، أسباب غير معروفة، أهله جاله إنه ممكن
+
+122
+00:09:07,980 --> 00:09:12,100
+يكون organ donor، organ donor يعني متبرع بالأعضاء
+
+123
+00:09:12,100 --> 00:09:16,820
+فأخذ القرنية منه و زرعوها لواحد ثاني، الثاني اللي
+
+124
+00:09:16,820 --> 00:09:23,290
+زرعوا له القرنية صار عنده rabies، إذن انتقلت من الـ .. الـ
+
+125
+00:09:23,290 --> 00:09:25,810
+الـ organ transplant، احنا كثير من الأمراض اللي
+
+126
+00:09:25,810 --> 00:09:28,790
+ذكرناهم زي الـ CMV و الـ Epstein-Barr Virus يكونوا
+
+127
+00:09:28,790 --> 00:09:31,910
+بينتقلوا عبر الـ organ transplantation، هاي كمان
+
+128
+00:09:31,910 --> 00:09:36,710
+واحد بينتقل عبر الـ organ transplantation، الآن في
+
+129
+00:09:36,710 --> 00:09:41,810
+الولايات المتحدة لا يزيد عدد حالات الـ .. الـ rabies عن
+
+130
+00:09:41,810 --> 00:09:47,210
+عشر حالات سنويًا، 200 مليون أو أكثر انسان عشر
+
+131
+00:09:47,210 --> 00:09:50,790
+حالات فقط، هذا رقم إيش ماله؟ رقم ضئيل، كمان مرة
+
+132
+00:09:50,790 --> 00:09:55,670
+اللي بيموتوا بحوادث إيش نسميها؟ حوادث دراجات أكثر
+
+133
+00:09:55,670 --> 00:09:59,090
+من اللي بيموتوا من هذا المرض، إذا الـ rabies well
+
+134
+00:09:59,090 --> 00:10:02,940
+-controlled في الـ western part، المشكلة أن حتى
+
+135
+00:10:02,940 --> 00:10:08,640
+الحالات في دولة غالبًا مستوردين إما لأمريكان كانوا
+
+136
+00:10:08,640 --> 00:10:13,120
+مسافرين برا ورجعوا أو لـ أو ناس جايين يزوروا
+
+137
+00:10:13,120 --> 00:10:16,480
+الولايات المتحدة أو مهاجرين للولايات المتحدة، إذا
+
+138
+00:10:16,480 --> 00:10:19,320
+يعني زي ما حكينا فيه و الـ control و الـ control هذا
+
+139
+00:10:19,320 --> 00:10:25,340
+كان سبب الرئيسي شغلتان: الـ vaccination للـ cats و الـ
+
+140
+00:10:25,340 --> 00:10:29,290
+dogs، رقم اثنين الـ Stray Dogs اللي هي الكلاب
+
+141
+00:10:29,290 --> 00:10:33,950
+الضالة، في مكافحة يعني شرسة في الولايات المتحدة
+
+142
+00:10:33,950 --> 00:10:37,250
+لكل الكلاب الضالة، فما نلاقيش كلاب في الشوارع إلا
+
+143
+00:10:37,250 --> 00:10:41,230
+إلها صاحب، إلها صاحب، و تالي، مدام إلها صاحب عشان
+
+144
+00:10:41,230 --> 00:10:45,490
+تقتني كلبًا لابد أو قطة يجب أن تكون لديك شهادات
+
+145
+00:10:45,490 --> 00:10:49,450
+تطعيم، زي ما بيقتني الإنسان إنسان، تمام؟ فيبقوا
+
+146
+00:10:49,450 --> 00:10:53,120
+فيها شهادات تطعيم لهذه الحيوانات، قولنا كوا في 2007
+
+147
+00:10:53,120 --> 00:10:57,840
+تم الإعلان عن الولايات المتحدة خالية من الـ rabies
+
+148
+00:10:57,840 --> 00:11:02,240
+مش أي rabies، الـ rabies اللي مسمين بسبب الكلاب اللي
+
+149
+00:11:02,240 --> 00:11:07,700
+هو بيسميه canine و canine معناها ناب، ناب، نابية
+
+150
+00:11:07,700 --> 00:11:12,580
+اللي هي من الكلاب، و زي ما ذكرنا حوالي خمسين ألف
+
+151
+00:11:12,580 --> 00:11:17,320
+حالة سنويًا بيصابوا بالـ rabies، طبعًا التوزيع
+
+152
+00:11:17,320 --> 00:11:22,170
+الجغرافي للخمسين ألف هو اللي بيفرق، في البلدان
+
+153
+00:11:22,170 --> 00:11:27,970
+العالم الثالث أكيد هيكون الوضع هنا أصعب من البلدان
+
+154
+00:11:27,970 --> 00:11:31,430
+العالم الـ industrialized أو المتطورة، الـ virus
+
+155
+00:11:31,430 --> 00:11:34,930
+multiplies locally at the bite site and fix the
+
+156
+00:11:34,930 --> 00:11:39,490
+sensory neurons، moves by axonal transport to the
+
+157
+00:11:39,490 --> 00:11:42,350
+central nervous system، يعني بيتكاثر في مكان
+
+158
+00:11:42,350 --> 00:11:45,890
+الإصابة وبينتقل عبر اللي هو الجهاز العصبي للـ
+
+159
+00:11:45,890 --> 00:11:50,200
+central nervous system، الآن خلال عملية الانتقال من
+
+160
+00:11:50,200 --> 00:11:54,440
+مكان العضة للـ central nervous system بيكون محمي،
+
+161
+00:11:54,440 --> 00:11:58,480
+ليش محمي؟ لأن هو جوا الـ .. الـ .. الـ central
+
+162
+00:11:58,480 --> 00:12:04,100
+nervous system، والـ immune system بيقدر عاليا الـ
+
+163
+00:12:04,100 --> 00:12:06,940
+central nervous system، بيحاول قدر الإمكان ما
+
+164
+00:12:06,940 --> 00:12:12,490
+يجربش عليه، عارفين ليش؟ أنتم بتعرفوا أن كثير من
+
+165
+00:12:12,490 --> 00:12:16,730
+الأمراض اللي احنا درسناهم، الضرر اللي حدث فينا كان
+
+166
+00:12:16,730 --> 00:12:19,710
+جارٍ على الـ immune system، فلو قلت لكم أنتم
+
+167
+00:12:19,710 --> 00:12:22,650
+تخيلوا إذا قاطع الضوء الأخضر الـ immune system
+
+168
+00:12:22,650 --> 00:12:26,830
+لمهاجمة الـ neurons، إيش هيصير فينا؟ أي infection،
+
+169
+00:12:26,830 --> 00:12:30,790
+أي infection بسيطة بتصيب الجهاز العصبي تبعنا، جهاز
+
+170
+00:12:30,790 --> 00:12:34,540
+اللي بنا عبدالله هشطل عليه، فبديدمر الـ neurons
+
+171
+00:12:34,540 --> 00:12:38,460
+إذا دمر الـ neurons يعني شلل يعني خرف يعني فقدر
+
+172
+00:12:38,460 --> 00:12:42,480
+للسمع يعني مظبوط ولا لأ؟ وبالتالي هو فهذا الفيروس
+
+173
+00:12:42,480 --> 00:12:46,280
+استغل هذا الوضع ودخل من خلال الـ central nervous
+
+174
+00:12:46,280 --> 00:12:52,780
+system، لذلك طول فترة انتقاله من مكان العضة إلى الـ
+
+175
+00:12:52,780 --> 00:12:56,980
+central nervous system غالبًا ما بيكون فيه مناعة أو
+
+176
+00:12:56,980 --> 00:13:01,420
+ردت فعل منعية، وإن كان ردت فعل منعية بتكون ضعيفة
+
+177
+00:13:01,420 --> 00:13:02,340
+للغاية.
+
+178
+00:13:05,210 --> 00:13:10,490
+هذه النقطة بدنا نسجلها في الذاكرة عشان نتكلم عن
+
+179
+00:13:10,490 --> 00:13:13,650
+اللي هو الـ immunization أو الـ vaccination بالـ
+
+180
+00:13:13,650 --> 00:13:15,150
+active و الـ passive immunization.
+
+181
+00:13:19,600 --> 00:13:22,240
+الجملة الثالثة بيقول الـ virus multiplies in the
+
+182
+00:13:22,240 --> 00:13:25,360
+central nervous system and then travels down the
+
+183
+00:13:25,360 --> 00:13:28,220
+peripheral nerve to the salivary gland and other
+
+184
+00:13:28,220 --> 00:13:31,000
+organs، لاحظوا هنا هملنا الـ other organs، بقولنا
+
+185
+00:13:31,000 --> 00:13:34,740
+other organs، بس ركزت على مين؟ على salivary gland،
+
+186
+00:13:34,740 --> 00:13:40,240
+ليه أهميتها في معاودة نقل المرض لآخر؟ from the
+
+187
+00:13:40,240 --> 00:13:43,100
+salivary gland it enters the saliva to be
+
+188
+00:13:43,100 --> 00:13:45,800
+transmitted by the bite، الكلام اللي حكيناه ما فيش
+
+189
+00:13:45,800 --> 00:13:50,360
+stage مؤشرة أنه الفيروس ما بيوصلش للدم وبالتالي
+
+190
+00:13:50,360 --> 00:13:53,740
+الردة الفعل المنعية اللي ذكرناها الضعيفة أحد
+
+191
+00:13:53,740 --> 00:13:58,220
+أسبابها أنه ما فيش وصول للدم within the central
+
+192
+00:13:58,220 --> 00:14:02,100
+nervous system، encephalitis develops سواء كان في
+
+193
+00:14:02,100 --> 00:14:06,310
+الحيوان أو في الإنسان، في encephalitis with the
+
+194
+00:14:06,310 --> 00:14:18,950
+death of neurons and demyelination، Demyelination
+
+195
+00:14:18,950 --> 00:14:23,850
+يعني إزالتها، لما نقول demyelinating diseases هي
+
+196
+00:14:23,850 --> 00:14:26,670
+الأمراض اللي تؤدي إلى الخرف، الخرف يعني فقدان
+
+197
+00:14:26,670 --> 00:14:28,430
+العقل.
+
+198
+00:14:42,080 --> 00:14:45,690
+النيرونات المصابة contains an eosinophilic
+
+199
+00:14:45,690 --> 00:14:48,010
+cytoplasmic تعرفهم inclusion اللي هو ماشي اسمهم
+
+200
+00:14:48,010 --> 00:14:51,890
+Negri bodies، احنا درسنا اثنين inclusion bodies
+
+201
+00:14:51,890 --> 00:14:55,850
+مهمين اللي هم في الـ CMV cytomegalovirus اللي
+
+202
+00:14:55,850 --> 00:14:59,210
+سميناهم owls eye و الـ Negri body اللي كنا قاعدينها في
+
+203
+00:14:59,210 --> 00:15:05,270
+الـ rabies وهي diagnostic يعني marker، because few
+
+204
+00:15:05,270 --> 00:15:11,750
+individuals have survived rabies، يعني
+
+205
+00:15:11,750 --> 00:15:17,370
+الناس اللي أصيبوا بالـ rabies وشوفوا منه هم قلة، هدول
+
+206
+00:15:17,370 --> 00:15:22,810
+القلة لم يتعرضوا لمرة أخرى لـ rabies عشان نقدر نفهم
+
+207
+00:15:22,810 --> 00:15:27,830
+كيف المناعة في المرة الثانية غرب ما يعرفش يعني ما فيش
+
+208
+00:15:27,830 --> 00:15:31,910
+حد أصيب بالـ rabies و أصيب في مرة أخرى عشان نفهم
+
+209
+00:15:31,910 --> 00:15:37,070
+كيف ردت فعل المناعة في هذه الحالة.
+
+210
+00:15:37,070 --> 00:15:45,970
+الـ ink .. يعني هو .. يعني هو مرض ولا .. أنه ردت
+
+211
+00:15:45,970 --> 00:15:48,850
+الفعل يعني ردت المناعة؟ لا احنا .. احنا إيش بنقول؟
+
+212
+00:15:48,850 --> 00:15:55,310
+بنقول أن لو افترضنا أن واحد عنده صار influenza تمام؟
+
+213
+00:15:56,140 --> 00:15:59,060
+وشو فيعمل الـ influenza؟ المرة الثانية صار اندو
+
+214
+00:15:59,060 --> 00:16:03,720
+انفلوانزا، إيش دور المناعة في مكافحة الـ influenza
+
+215
+00:16:03,720 --> 00:16:07,260
+في المرة الثانية؟ نجرب ندرسه، لأن هو اتعرض في
+
+216
+00:16:07,260 --> 00:16:09,560
+المرة الأولى، الآن في الـ rabies ما فيش حاجة أن
+
+217
+00:16:09,560 --> 00:16:13,380
+الناس اتعرضوا مرتين، اتعرض مرة وما فيش مرة اتعرض
+
+218
+00:16:13,380 --> 00:16:17,320
+تانية، فهم مش عارفين إيش التصرف، تبقى لازم يكون لو
+
+219
+00:16:17,320 --> 00:16:23,460
+تعرض لهذا الـ virus مرة أخرى، في نقطة هنا كثير مهمة
+
+220
+00:16:23,460 --> 00:16:25,580
+الـ incubation period اللي احنا ناقشناها من بارحة
+
+221
+00:16:25,580 --> 00:16:28,540
+لما قولنا ليش بتختلف الـ incubation period و ذكرنا
+
+222
+00:16:28,540 --> 00:16:33,000
+لكم نموذج أن الـ site of entry أو المكان اللي عضّى
+
+223
+00:16:33,000 --> 00:16:38,000
+تمام، مثلًا قولنا بتروح من أسبوعين إلى ستة عشر أسبوع
+
+224
+00:16:38,000 --> 00:16:43,580
+نصف شهر لقداش لأربع شهور، تخيلوا أربع شهور الـ
+
+225
+00:16:43,580 --> 00:16:50,780
+incubation period ستة عشر أسبوع or longer أو أطول
+
+226
+00:16:51,790 --> 00:16:56,470
+الآن مالذي يجعل هذا الفرق الكبير؟ احنا قولنا
+
+227
+00:16:56,470 --> 00:17:00,150
+مجموعة من العناصر المرة الماضية، نوع الـ .. الـ ..
+
+228
+00:17:00,150 --> 00:17:05,150
+الـ .. الفيروس، صح؟ اثنين، مكان الإصابة، ثلاثة،
+
+229
+00:17:05,150 --> 00:17:08,970
+الجرعة، والرابع يقولنا الـ immunity، وإذا
+
+230
+00:17:08,970 --> 00:17:13,830
+كان في previous immunity عند الشخص، هنا العامل الأهم
+
+231
+00:17:13,830 --> 00:17:16,090
+هو فيروس واحد، عارفين احنا هو الـ rabies و single
+
+232
+00:17:16,090 --> 00:17:19,550
+serotype، ما فيش فيه نوع، ما فيش فيه أنواع فما فيش هذا
+
+233
+00:17:19,550 --> 00:17:22,810
+الـ variable مش موجود، الـ variable الوحيد هنا شغلتان
+
+234
+00:17:22,810 --> 00:17:26,690
+الـ concentration of the virus with sight of bite
+
+235
+00:17:26,690 --> 00:17:30,710
+with sight of bite و الـ depth of bite، يعني لو كانت
+
+236
+00:17:30,710 --> 00:17:35,990
+superficial ولا deep، تمام؟ أنتم عارفين الحيوانات
+
+237
+00:17:35,990 --> 00:17:39,890
+يعني القطة غير عن الكلب مظبوط في الحجم الأنياب
+
+238
+00:17:39,890 --> 00:17:44,470
+بتبعثها ومكان عمق اللي هو الدخول، إذا هذه العوامل
+
+239
+00:17:44,470 --> 00:17:46,630
+هي اللي بتأثر على الـ incubation period اللي بتكون
+
+240
+00:17:46,630 --> 00:17:51,330
+قصيرة لو كانت العضة في الرأس أو في منطقة الرأس
+
+241
+00:17:51,330 --> 00:17:53,910
+يعني في الأذن في الرقبة في الكتف بيكون الـ
+
+242
+00:17:53,910 --> 00:17:57,450
+incubation period short، لو كانت في الـ leg بتكون
+
+243
+00:17:57,450 --> 00:18:01,950
+الفترة incubation طويلة، طبعًا هذا اللي سمح لنا أن نتدخل
+
+244
+00:18:01,950 --> 00:18:06,210
+قبل ظهور العرض أن في عندنا incubation طويلة، المثالين
+
+245
+00:18:06,210 --> 00:18:08,710
+اللي ذكرناهم في الـ active passive immunization و
+
+246
+00:18:08,710 --> 00:18:12,750
+الـ post exposure كانت الفكرة فيهم أن الـ 10 10 have
+
+247
+00:18:12,750 --> 00:18:16,480
+long incubation period، Clinically, the patient
+
+248
+00:18:16,480 --> 00:18:19,960
+exhibits a prodrome of non-specific symptoms, such
+
+249
+00:18:19,960 --> 00:18:24,060
+as fever, anorexia, and changes in sensation at
+
+250
+00:18:24,060 --> 00:18:25,520
+the bite site.
+
+251
+00:18:31,080 --> 00:18:37,640
+Within a few days, signs such as confusion مين أنت؟ 
+
+252
+00:18:37,640 --> 00:18:42,740
+ينسى، مايركز، هذا اسمه confusion الآن الثانية ال
+
+253
+00:18:42,740 --> 00:18:46,440
+lethargy اللي هو الخمول قد نجد إنسان .. قد نجد
+
+254
+00:18:46,440 --> 00:18:54,220
+إنسان متقطّع الرأس شبه نايم وهو جالس تمام ماعندوش 
+
+255
+00:18:54,220 --> 00:18:58,900
+الحركة العادية تبع الأشخاص حتى لو كان مريض مرض آخر
+
+256
+00:18:58,900 --> 00:19:03,020
+ممكن يتحرك ويتكلم زي الـ influenza لكن لما بيقول
+
+257
+00:19:03,020 --> 00:19:08,790
+lethargic يعني خامل هذه نية ما بيعمل الحركات
+
+258
+00:19:08,790 --> 00:19:14,590
+الطبيعية تبع الإنسان اللي بيعملها بشكل طبيعي جوانا
+
+259
+00:19:14,590 --> 00:19:17,790
+lethargy and increased salivation اللي هو زيادة في
+
+260
+00:19:17,790 --> 00:19:23,030
+إنتاج اللعاب most notable وهذه ملاحظة يعني برضه 
+
+261
+00:19:23,030 --> 00:19:29,070
+مميزة اللي هو القَلَم عند البلع وهذا بيولد .. القَلَم
+
+262
+00:19:29,070 --> 00:19:33,130
+عند البلع بيولد عند المرضى الخوف من الماء بيسمّوه
+
+263
+00:19:33,130 --> 00:19:36,330
+hydrophobia أنه بيصير خائف من الميه لأن الميه
+
+264
+00:19:36,330 --> 00:19:40,130
+بتمثّل له الشيء اللي بيشربه ولو بيشربه بيبلعه برضه
+
+265
+00:19:40,130 --> 00:19:43,430
+مظبوط فمؤلم جدا بيكون وبالتالي بيصير عنده 
+
+266
+00:19:43,430 --> 00:19:48,010
+hydrophobia within several days the disease
+
+267
+00:19:48,010 --> 00:19:52,750
+progressed to seizure يعني تشنجات ممكن يصير في شلل
+
+268
+00:19:52,750 --> 00:19:57,520
+وممكن يصل للكوما إذا وصل للكوما، غالباً بيقولنا الـ
+
+269
+00:19:57,520 --> 00:20:04,080
+death almost invariably ensue، يعني بيتبع هذا
+
+270
+00:20:04,080 --> 00:20:11,880
+الأعراض، بيتبعه ما هو الموت، but with the advent of
+
+271
+00:20:11,880 --> 00:20:14,740
+life support system, a few individuals have
+
+272
+00:20:14,740 --> 00:20:20,300
+survived مع وجود الأجهزة الحديثة اللي بتدعم الحياة
+
+273
+00:20:20,300 --> 00:20:23,240
+زي أجهزة التنفس الصناعي بعض المرضى حتى اللي يروح
+
+274
+00:20:23,240 --> 00:20:28,260
+عليهم أعراض ممكن يعني ينجوا من هذا المرضى طبعاً مش
+
+275
+00:20:28,260 --> 00:20:34,040
+بدون علاج بعلاج تمام؟ والبعض الآخر مع وجود العلاج
+
+276
+00:20:34,040 --> 00:20:36,820
+اللي هو الـ vaccine والـ immunoglobulin برضه 
+
+277
+00:20:36,820 --> 00:20:42,400
+بيموتوا مدى إن ظهرت هذه الأعراض الـ lab diagnosis
+
+278
+00:20:42,400 --> 00:20:53,560
+قلنا لكم إن الإنسان
+
+279
+00:20:53,560 --> 00:20:57,660
+اللي
+
+280
+00:20:57,660 --> 00:21:02,720
+يسبب الأذى هو الحيوان اللي يجيبه معنا نجيب معانا
+
+281
+00:21:02,720 --> 00:21:08,100
+في المستشفيات إذا صار في report إنه حدّ تعرض لعدة
+
+282
+00:21:08,100 --> 00:21:11,860
+مش هنا برا إن هنا بممكن الأهالي يساعدوا في هذا
+
+283
+00:21:11,860 --> 00:21:15,880
+الموضوع إنه والله في كلب بيلفّ في المنطقة هذه هو
+
+284
+00:21:15,880 --> 00:21:19,320
+اللي عضّ هذا الشخص جيبوه وادّوه على المستشفى عشان
+
+285
+00:21:19,320 --> 00:21:22,980
+يراقبوا الـ behavior تبع الكلب هذا واحد اثنين ممكن
+
+286
+00:21:22,980 --> 00:21:27,180
+ناخده منه عينات من الدماغ ونعمل فحص نشوف نجري
+
+287
+00:21:27,180 --> 00:21:31,540
+bodies إذا الحيوان مصاب لازم المريض ياخد active
+
+288
+00:21:31,540 --> 00:21:37,380
+passive immunization هذا لما يكون dogs في الولايات
+
+289
+00:21:37,380 --> 00:21:40,940
+المتحدة إنّها مقارنة بتقول لو كان wild animal والـ
+
+290
+00:21:40,940 --> 00:21:45,370
+animal غضب مش هنقدر نمسكه فسواء مصاب ولا مش مصاب،
+
+291
+00:21:45,370 --> 00:21:49,270
+مدام العضة من .. من wild animal تمام؟ وفي نقطة هنا
+
+292
+00:21:49,270 --> 00:21:53,830
+ممكن يعني برضه الـ .. الأطباء يسألوها للمريض، هل
+
+293
+00:21:53,830 --> 00:21:59,610
+اتعرضت للعضة دون ما سابق إنذار ولا كان فيه بينك
+
+294
+00:21:59,610 --> 00:22:04,660
+وبين الحيوان أخدعطة؟ كيف أخدعطة يعني؟ يعني أنت
+
+295
+00:22:04,660 --> 00:22:08,420
+عملت له provoke، أنت استفزّته، أنت استفزّيته، ضربت
+
+296
+00:22:08,420 --> 00:22:12,460
+عليه حجر، مسكت عليه عصاية، حاولت تؤذيه، هذا اسمه
+
+297
+00:22:12,460 --> 00:22:18,600
+provoke، provoke يعني استفزّ الحيوان من طباعة
+
+298
+00:22:18,600 --> 00:22:22,320
+الحيوانات العادية، أنا ما بتهجم على الإنسان بشكل
+
+299
+00:22:22,320 --> 00:22:26,940
+زي الكلاب والقطط إلا إذا استفزّها واحد أو حاول إنه
+
+300
+00:22:26,940 --> 00:22:30,840
+يؤذيها فالقرار إنه نعطي أو ما نعطي معتمد على
+
+301
+00:22:30,840 --> 00:22:33,800
+مجموعة من العوامل اللي هنمرّ عليها في نهاية اللي هو
+
+302
+00:22:33,800 --> 00:22:36,820
+المحاضرة لما نتكلم عن الـ treatment أو الـ
+
+303
+00:22:36,820 --> 00:22:40,280
+prevention المهم إنه احنا بنقول إن الـ diagnosis
+
+304
+00:22:40,280 --> 00:22:45,060
+مرتبط برضه بمين بالحيوان اللي موجود أو اللي سبّب
+
+305
+00:22:45,060 --> 00:22:49,130
+الأذى نجري bodies في الـ cytoplasmic inclusions
+
+306
+00:22:49,130 --> 00:22:55,370
+للنيورونات تبع الحيوان وجودها هذا diagnostic marker
+
+307
+00:22:55,370 --> 00:22:59,530
+مهم جدا في الـ rabies الفيروس could be isolated
+
+308
+00:22:59,530 --> 00:23:03,290
+from the animal brain by growing in cell culture
+
+309
+00:23:03,290 --> 00:23:08,070
+لكن للأسف هذا بياخد وقت طويل وهذا بيعيق القرار إنه
+
+310
+00:23:08,070 --> 00:23:11,690
+نعطي أو ما نعطي اللي هو الـ active passive
+
+311
+00:23:11,690 --> 00:23:16,400
+immunization الرايبز من الـ human يعني لو واحد ضحّى
+
+312
+00:23:16,400 --> 00:23:21,580
+عليه أعراض وشاكين إنّها رايبز ما بناخدلهوش brain
+
+313
+00:23:21,580 --> 00:23:25,320
+ما بناخدلهوش brain cells ايش ممكن ناخدله؟ ما بناخدله
+
+314
+00:23:25,320 --> 00:23:30,860
+skin من منطقة الرقبة وين منبت الشعر في الرقبة
+
+315
+00:23:30,860 --> 00:23:36,240
+بناخد biopsy وبنعملها staining وبنشوف إذا كان
+
+316
+00:23:36,240 --> 00:23:39,860
+فيها أما باستخدام الـ fluorescent labels antibody
+
+317
+00:23:39,860 --> 00:23:42,300
+أو باستخدام الـ staining العادي عشان نشوف اللي هو
+
+318
+00:23:42,300 --> 00:23:47,840
+الـ negri bodies يبقى الـ skin of the neck at the
+
+319
+00:23:47,840 --> 00:23:48,800
+hairline
+
+320
+00:23:52,160 --> 00:23:54,580
+isolation of the virus from sources such as
+
+321
+00:23:54,580 --> 00:23:58,440
+saliva, spinal fluid and brain tissue برضه موجودة
+
+322
+00:23:58,440 --> 00:24:02,600
+ارتفاع في الـ antibody tighter negri bodies can be
+
+323
+00:24:02,600 --> 00:24:06,140
+demonstrated from corneal scrapping تذكروا قبل
+
+324
+00:24:06,140 --> 00:24:11,960
+قليل قلنا لكم إنه في أحد الحالات اللي تمّ إحداث الـ
+
+325
+00:24:11,960 --> 00:24:15,140
+rabies من خلالها هو نقل الكورنيا فالقرنية بيحتوي
+
+326
+00:24:15,140 --> 00:24:18,580
+على الـ virus وبالتالي ممكن نعمل corneal scrapping
+
+327
+00:24:18,580 --> 00:24:24,210
+وفي حالة الوفاة بعد موت الإنسان لأ بقص إنك تاخد منه
+
+328
+00:24:24,210 --> 00:24:27,630
+عينة من الدماغ تبقى أو حتى اللي هو طالع إنه أنا
+
+329
+00:24:27,630 --> 00:24:31,850
+الآن هو إنسان ميت، ايش بنسمي العينة من الميت؟
+
+330
+00:24:31,850 --> 00:24:37,270
+Autopsy، تمام؟ Autopsy There is no antiviral
+
+331
+00:24:37,270 --> 00:24:40,590
+therapy for patients with rabies، مافي أي علاج
+
+332
+00:24:40,590 --> 00:24:45,230
+نكافح فيه هذا الفيروس، only supportive treatment،
+
+333
+00:24:45,230 --> 00:24:48,990
+ايش يعني supportive treatment؟ يعني عنده seizure
+
+334
+00:24:48,990 --> 00:24:53,810
+بنعطيه Anti-epileptic، عنده مثلاً نقص في التنفس
+
+335
+00:24:53,810 --> 00:24:57,090
+بنحط له Oxygen زيادة، عنده ارتفاع في الحرارة،
+
+336
+00:24:57,090 --> 00:25:01,650
+مسكّنات، هذا اسمه supportive treatment، ليس علاج للـ
+
+337
+00:25:01,650 --> 00:25:06,590
+disease نفسه لـ prevention there are two approaches
+
+338
+00:25:06,590 --> 00:25:11,230
+to prevention of rabies in human واحد الـ pre
+
+339
+00:25:11,230 --> 00:25:15,410
+exposure and post exposure طبعاً الـ pre exposure هو
+
+340
+00:25:15,410 --> 00:25:19,470
+السياسة العامة السياسة العامة اللي متابعينها أصلاً في
+
+341
+00:25:19,470 --> 00:25:22,990
+كل الـ vaccination لكن يا هلتر عشان خمسين ألف واحد
+
+342
+00:25:22,990 --> 00:25:26,230
+في كل العالم بينصابوا بالـ rabies انطعم كل سكان
+
+343
+00:25:26,230 --> 00:25:31,010
+العالم مش منطقي ولا لأ؟ فعليش نلجأ لمن؟ نلجأ للـ ..
+
+344
+00:25:32,690 --> 00:25:36,410
+للفئات الأكثر عرضة للإصابة بالـ rapes مين مثلاً
+
+345
+00:25:36,410 --> 00:25:41,510
+لطبّاء البيطريين المساكين اللي عاملين في حدائق
+
+346
+00:25:41,510 --> 00:25:45,730
+الحيوان أو الناس اللي بيسافروا إلى أماكن موبوءة
+
+347
+00:25:45,730 --> 00:25:51,130
+هدول بيعملهم pre exposure قبل ما يتعرض بيقولوا
+
+348
+00:25:51,130 --> 00:25:54,490
+أنت ممنوع تعمل هذه الوظيفة أو تشتغل هذه الوظيفة
+
+349
+00:25:54,490 --> 00:25:59,700
+إلا تاخد هذا الـ vaccine متفقين عليها؟ إذا مين هم؟
+
+350
+00:25:59,700 --> 00:26:03,360
+Veterinarians، Zoo keepers اللي هم اللي عاملين في
+
+351
+00:26:03,360 --> 00:26:07,040
+حدائق الحيوانات و Travelers to areas of
+
+352
+00:26:07,040 --> 00:26:09,460
+hyperendemic infection يعني بيكون المرض فيها
+
+353
+00:26:09,460 --> 00:26:14,440
+مستوطن بشكل كبير الـ Pre exposure immunization
+
+354
+00:26:14,440 --> 00:26:18,500
+consists of three doses تُعطى على صفر، صفر يعني
+
+355
+00:26:18,500 --> 00:26:22,940
+الآن، لحظة، هذه اللحظة، سبعة أيام، واحد وعشرين أو
+
+356
+00:26:22,940 --> 00:26:27,760
+ثمانية وعشرين يعني هاد ماشي أربع جولات صار تلاتة بس
+
+357
+00:26:27,760 --> 00:26:30,460
+بدل الواحد وعشرين ممكن نبدلها منين ثمانية وعشر
+
+358
+00:26:30,460 --> 00:26:36,660
+الـ booster dose are given as needed ايش يعني as
+
+359
+00:26:36,660 --> 00:26:41,060
+given .. are given as needed يعني تُعطى حسب الحاجة
+
+360
+00:26:41,060 --> 00:26:45,160
+ايش يعني حسب الحاجة واحد بطّل يشتغل في الـ .. في
+
+361
+00:26:45,160 --> 00:26:50,140
+الحديقة الحيواني هل في داعي إن هو على طول كل فترة
+
+362
+00:26:50,140 --> 00:26:56,150
+يعمل booster dose طب واحد ضلّ يشتغل كل كم سنة فيه
+
+363
+00:26:56,150 --> 00:26:59,330
+لاجوا variation بين الناس في الـ response للـ
+
+364
+00:26:59,330 --> 00:27:02,470
+immunization فاكر لك إذا كان بقى اللي عنده
+
+365
+00:27:02,470 --> 00:27:06,730
+antibody tighter أقل من واحد إلى خمسة اعطيه booster
+
+366
+00:27:06,730 --> 00:27:11,070
+dose إذا واحد إلى خمسة وفوق تعطّيهوش booster dose
+
+367
+00:27:11,070 --> 00:27:14,470
+بمعنى إنه حدّد الـ tighter أو التركيز تبع الـ
+
+368
+00:27:14,470 --> 00:27:19,210
+antibody تركيز أقوى الـ antibody below which you
+
+369
+00:27:19,210 --> 00:27:24,550
+should be exposed to a booster dose
+
+370
+00:27:27,370 --> 00:27:30,090
+The rabies vaccine is the only vaccine that is
+
+371
+00:27:30,090 --> 00:27:32,230
+routinely used post-exposure.
+
+372
+00:27:58,450 --> 00:28:02,130
+The long incubation period of the disease allows
+
+373
+00:28:02,130 --> 00:28:05,490
+the virus in the vaccine sufficient time to induce
+
+374
+00:28:05,490 --> 00:28:09,690
+protective immunity. إذن هي بالفعل الـ incubation
+
+375
+00:28:09,690 --> 00:28:14,270
+period الطويلة التي سمحت لنا أو سمحت للفاكسين أنه
+
+376
+00:28:14,270 --> 00:28:21,210
+يعطي immunity كافية للتخلص من الفيروس post 
+
+377
+00:28:21,210 --> 00:28:22,730
+exposure immunization
+
+378
+00:28:26,280 --> 00:28:32,840
+وهو rabies immunoglobulin، من أين حصلنا عليه؟ من
+
+379
+00:28:32,840 --> 00:28:34,380
+شخصين شخصيين اللي هم الـ hyper immunized
+
+380
+00:28:37,920 --> 00:28:42,360
+إما وناس أصيبوا في السابق و أعطوا vaccine أو
+
+381
+00:28:42,360 --> 00:28:46,280
+volunteers أو مُتطوعين طبعا كلمة مُتطوعين يعني
+
+382
+00:28:46,280 --> 00:28:51,780
+غالبا ما فيش تطوع مجاني يعني غالبا فيه خلينا نقول
+
+383
+00:28:51,780 --> 00:28:56,140
+مزايا تُعطى فاسمهم مُتطوعين وهذا كانت تطوع وهذا
+
+384
+00:28:56,140 --> 00:29:00,260
+شراء وهذا شراء زي ما أقول لكم اللي بتطوع بيعطيه
+
+385
+00:29:00,260 --> 00:29:05,320
+خمس علامات صارت تطوع ومع ذلك لو جيناكوا تطوع بخمس
+
+386
+00:29:05,320 --> 00:29:06,040
+علامات بتطوع ولا
+
+387
+00:29:09,560 --> 00:29:12,760
+طيب plus immediate cleaning of the wound يعني
+
+388
+00:29:12,760 --> 00:29:16,480
+تطهير الجرح برضه كمان عملية مهمة جدا في هذه الحالة
+
+389
+00:29:16,480 --> 00:29:20,200
+and this is an example of active passive
+
+390
+00:29:20,200 --> 00:29:23,640
+immunization tetanus immunization should also be
+
+391
+00:29:23,640 --> 00:29:30,060
+considered لأنه زي ما احنا بنقول إن الـ الـ
+
+392
+00:29:33,160 --> 00:29:37,240
+الأشياء الصادقة أو الملوثة بالتربة قد تنقل
+
+393
+00:29:37,240 --> 00:29:41,720
+تيتانوس، أيضًا بعض الحيوانات قد تنقل أيضًا
+
+394
+00:29:41,720 --> 00:29:42,440
+التيتانوس
+
+395
+00:29:46,990 --> 00:29:51,390
+passive immunity أو active immunity لأن احنا جالبا كلنا
+
+396
+00:29:51,390 --> 00:29:55,630
+متعامل ضد تتانوس فيكفي نعطي toxoid عشان نعمل
+
+397
+00:29:55,630 --> 00:30:00,010
+induction لـ secondary response وبيعطي immediate
+
+398
+00:30:00,010 --> 00:30:04,130
+response للـ antibodies ضد تتانوس، إذا تتانوس و
+
+399
+00:30:04,130 --> 00:30:07,450
+rabies ممكن ينتقلوا بنفس اللي هو الوسيلة
+
+400
+00:30:10,740 --> 00:30:15,220
+القرار أن نقوم بإعطاء post exposure immunization
+
+401
+00:30:15,220 --> 00:30:19,400
+بيعتمد على مجموعة من العوامل كما ذكرنا قبل قليل The
+
+402
+00:30:19,400 --> 00:30:23,880
+type of animal إذا كان wild أو domestic قلنا لكم
+
+403
+00:30:23,880 --> 00:30:28,940
+all wild animals demands immunization العضة من
+
+404
+00:30:28,940 --> 00:30:34,160
+حيوان بري تتطلب تمنيع تمنيع اللي هو الـ active
+
+405
+00:30:34,160 --> 00:30:38,300
+immunization Whether an attack by a domestic animal
+
+406
+00:30:38,300 --> 00:30:41,520
+was provoked، قلنا لكم كلمة provoked يعني تم
+
+407
+00:30:41,520 --> 00:30:45,060
+استفزازه، إذا تم استفزازه مع الحكي أنه غالبا مش
+
+408
+00:30:45,060 --> 00:30:49,520
+هيكون بسبب الـ rabies، هو عضمة، عضمة بسبب أنه يدفع
+
+409
+00:30:49,520 --> 00:30:54,550
+عن نفسه whether the animal was immunized adequately
+
+410
+00:30:54,550 --> 00:30:58,290
+إذا كان الحيوان نفسه اللي ستسبب بالعدة هل كان هو
+
+411
+00:30:58,290 --> 00:31:02,330
+مطعم ولا غير مطعم and whether the animal is
+
+412
+00:31:02,330 --> 00:31:06,790
+available to be observed هل الحيوان متوفر موجود؟
+
+413
+00:31:06,790 --> 00:31:13,750
+انت بتعرفه في موضوع الحياة، الثعابين، لو واحد
+
+414
+00:31:13,750 --> 00:31:17,490
+جرسته حياة انتوا عارفين ان فين ده؟ احنا أنواع
+
+415
+00:31:17,490 --> 00:31:21,270
+الثعابين و الحياة، و السم تبعتها أنواع، غالبا كل
+
+416
+00:31:21,270 --> 00:31:24,570
+دولة بيكون عندها registry في كل .. في أنواع
+
+417
+00:31:24,570 --> 00:31:27,550
+الثعابين وعندها antivenom، antivenom يعني
+
+418
+00:31:27,550 --> 00:31:30,450
+antibody ضد مين، ضد السم تبعت هذه الثعابين ..
+
+419
+00:31:30,450 --> 00:31:35,690
+الثعابين، اليوم لما أنا واحد يصير عنده عضة ثعبان،
+
+420
+00:31:35,690 --> 00:31:41,270
+طبعا الثعبان إلو marks قد تكون واضحة وقد لا تكون
+
+421
+00:31:41,270 --> 00:31:46,150
+واضحة الـ marks هذه في مكان العضة قد تكون مميزة
+
+422
+00:31:46,150 --> 00:31:50,570
+للثعبان وقد لا تكون مميزة للثعبان الوسيلة الأمثل
+
+423
+00:31:50,570 --> 00:31:54,490
+عشان أنا أعطي antitoxin antivenom تمام أمثل أن
+
+424
+00:31:54,490 --> 00:32:00,390
+نجيب الثعبان اللي اللي تسبب بالعضة طبعا مش معقول
+
+425
+00:32:00,390 --> 00:32:05,130
+لنفس الشخص اللي لكن ممكن يعطي هو الـ location
+
+426
+00:32:05,130 --> 00:32:10,810
+الجيوجرافي وفيكونوا مسئولين في كل منطقة عن
+
+427
+00:32:10,810 --> 00:32:14,170
+الحياة البرية، هم اللي بيروحوا يدوروا على هذا
+
+428
+00:32:14,170 --> 00:32:17,750
+الثعبان إذا أحضروا للطبيب وعرفت الطبيب أن هو
+
+429
+00:32:17,750 --> 00:32:22,130
+الثعبان، بصير سهل جدا عملية المعالجة، وبالتالي
+
+430
+00:32:22,130 --> 00:32:27,450
+نفس الجثة نقول أن أفضل وسيلة أن نتعرف على أن العضة
+
+431
+00:32:27,450 --> 00:32:32,430
+هذه تستوجب الـ immunization نجيب اللي هو الحيوان
+
+432
+00:32:32,430 --> 00:32:36,310
+اللي تسبب بهذه العضة، وعن برة قلت لكم كمان اللي هو
+
+433
+00:32:36,310 --> 00:32:41,580
+المكافحة الـ .. الـ stray dogs أو الكلاب الضالة يعني
+
+434
+00:32:41,580 --> 00:32:44,460
+هي مؤسسة عندهم باعتبارها مؤسسة ضخمة وكبيرة وتقعد
+
+435
+00:32:44,460 --> 00:32:48,260
+على تلقّي في الشوارع فمن السهل جدا إنه برضه تبلغ ويحضروا 
+
+436
+00:32:48,260 --> 00:32:51,280
+هذه الكلبة طبعا احنا عندنا هذا الكلام
+
+437
+00:32:51,280 --> 00:32:56,200
+مابوصل whether rabies is endemic in the area يعني
+
+438
+00:32:56,200 --> 00:32:58,640
+احنا في غزة مابوصل لأن اصلا احنا ما عندناش rabies
+
+439
+00:32:58,640 --> 00:33:01,800
+يعني احنا من سنوات طويلة لم نسمع بأن في عندنا حالة
+
+440
+00:33:01,800 --> 00:33:08,910
+من حالات الـ rabies في قطاع غزة إذا قررنا إنه بنعمل
+
+441
+00:33:08,910 --> 00:33:13,110
+immunization both human-diplod cell vaccine
+
+442
+00:33:13,110 --> 00:33:18,270
+الفيروس
+
+443
+00:33:18,270 --> 00:33:27,890
+تم تنميته على human-diplod cell culture and
+
+444
+00:33:27,890 --> 00:33:29,590
+RIG are recommended
+
+445
+00:33:34,840 --> 00:33:42,160
+Five doses of HDCV are given on day 0, 3, 7, 14
+
+446
+00:33:42,160 --> 00:33:49,420
+and 28 يبقى فاكرين في الأول كم جرعة كانوا الـ Pre
+
+447
+00:33:49,420 --> 00:33:55,800
+كانوا تلاتة هنا خمس جرعات صفر تلاتة سبعة اربعتاش
+
+448
+00:33:55,800 --> 00:33:59,180
+تمانعاشين والـ RIG اللي هو الـ rabies immunoglobulin
+
+449
+00:33:59,180 --> 00:34:04,200
+يُعطى مرة واحدة فقط للبنت في نفس اليوم اللي بنعطيه
+
+450
+00:34:04,200 --> 00:34:07,220
+الجرعة الأولى، اللي هو الـ Zero Day، اللي هو يعني
+
+451
+00:34:07,220 --> 00:34:10,800
+اليوم الأول، تمام؟ ما بنعطيهوش على فترات، بنعطيه
+
+452
+00:34:10,800 --> 00:34:14,980
+مرة واحدة، وين بنحقنه؟ بنحقنه في مكان الإصابة
+
+453
+00:34:14,980 --> 00:34:19,860
+نفسها، وهذا المشكلة لو كان الشخص قد تعرض لعدة
+
+454
+00:34:19,860 --> 00:34:25,200
+إصابات مختلفة في نفس مكان العضة، هذا المشكلة فبتنوزع الـ
+
+455
+00:34:25,200 --> 00:34:28,980
+Immunoglobulin على المناطق المختلفة من هذه العضة،
+
+456
+00:34:28,980 --> 00:34:33,070
+برضه مش هذه القصة القصة الأخطر إن هو بده يحط الـ
+
+457
+00:34:33,070 --> 00:34:35,970
+vaccine يعني أنا بقول إن دايما الـ vaccine بده
+
+458
+00:34:35,970 --> 00:34:39,670
+يكون في منطقة بعيدة عن المناطق اللي حطيت فيها الـ
+
+459
+00:34:39,670 --> 00:34:44,050
+immunoglobulin فهذه تماما مشكلة لكن في الآخر I
+
+460
+00:34:44,050 --> 00:34:47,470
+have no choice but to give the two لازم نعطي اثنين
+
+461
+00:34:47,470 --> 00:34:49,410
+مع بعض
+
+462
+00:34:52,970 --> 00:34:59,770
+As much as possible of the RIG is
+
+463
+00:34:59,770 --> 00:35:03,590
+given into the bite site and the reminder is given
+
+464
+00:35:03,590 --> 00:35:04,650
+intramuscular
+
+465
+00:35:17,860 --> 00:35:20,240
+If the animal has been captured, it should be
+
+466
+00:35:20,240 --> 00:35:23,340
+observed for 10 days and observed if symptoms
+
+467
+00:35:23,340 --> 00:35:26,680
+develop برضه كمان هذه نقطة من النقاط لـ Prevention
+
+468
+00:35:26,680 --> 00:35:30,480
+عشان احنا ناخد القرار أما نعدم الحيوان أو ما
+
+469
+00:35:30,480 --> 00:35:33,960
+نعدموش برضه هذه نقطة مهمة The brain of the animal
+
+470
+00:35:33,960 --> 00:35:36,700
+should be examined by immunofluorescence كلمة
+
+471
+00:35:36,700 --> 00:35:39,740
+immunofluorescence يعني antibody labelled with
+
+472
+00:35:39,740 --> 00:35:43,470
+اللي هو Fluorescein The vaccine for immunization of
+
+473
+00:35:43,470 --> 00:35:48,090
+dogs and cats consists of inactivated rabies virus
+
+474
+00:35:57,280 --> 00:36:01,160
+The first immunization is usually given at three
+
+475
+00:36:01,160 --> 00:36:06,840
+months of age، ثلاث شهور من حياة الحيوان، with a
+
+476
+00:36:06,840 --> 00:36:11,080
+booster dose either given annually يعني كل سنة أو
+
+477
+00:36:11,080 --> 00:36:15,340
+at three years interval، طبعا برضه كمان مرة، في
+
+478
+00:36:15,340 --> 00:36:19,210
+فرق كبير بين كلمة سنة وكل ثلاث سنين it depends upon
+
+479
+00:36:19,210 --> 00:36:22,890
+the type of animal يعني الـ veterinary هو اللي
+
+480
+00:36:22,890 --> 00:36:30,310
+بيقرر هل نعطيها سنويا ولا كل ثلاث سنوات الفيروس
+
+481
+00:36:30,310 --> 00:36:33,110
+اللي هيكون معنا المرة القادمة إن شاء الله هو human
+
+482
+00:36:33,110 --> 00:36:37,630
+T cell lymphotropic virus وهذا الفيروس اللي
+
+483
+00:36:37,630 --> 00:36:43,570
+بيطلعلنا خلايا جميلة لكنها خلايا سلطانية نختم فيها
+
+484
+00:36:43,570 --> 00:36:49,800
+الصورة المحاضرة عشان المرة الجاية نكون عارفين الـ
+
+485
+00:36:49,800 --> 00:36:54,040
+flower shaped cells اللي بنشوفها في الـ blood
+
+486
+00:36:54,040 --> 00:36:56,940
+اسمها، نراكم إن شاء الله المرة القادمة
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/QvUu9hWKCrM_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/QvUu9hWKCrM_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ebd52f11a07ae573ad7de91295b31021961f175f
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/QvUu9hWKCrM_raw.srt
@@ -0,0 +1,1944 @@
+1
+00:00:21,090 --> 00:00:23,630
+بسم الله الرحمن الرحيم، الحمد لله رب العالمين
+
+2
+00:00:23,630 --> 00:00:30,330
+ضيانة فيروسين في المجموعة ال rabies أحدهم نبدأ بال
+
+3
+00:00:30,330 --> 00:00:36,190
+rabies اللي يمكن أن يصنف على أنه ال virus الأكثر
+
+4
+00:00:36,190 --> 00:00:40,930
+قتلا أو أكثر قدر على القتل في العالم، ليش؟ لأن كل
+
+5
+00:00:40,930 --> 00:00:45,770
+الحالات التي لا تعالج من هذا ال virus تنتهي بالموت
+
+6
+00:00:46,250 --> 00:00:50,470
+يعني مافيش نسبة شفاء أو نسبة وفيات معينة بنقول
+
+7
+00:00:50,470 --> 00:00:55,010
+hundred percent fatality rate if untreated، إذن
+
+8
+00:00:55,010 --> 00:00:58,650
+هذا معرض من أو فيروس من أخطر الفيروسات على وجه
+
+9
+00:00:58,650 --> 00:01:05,180
+الأرضاللي بيخلّينا ما نهتمش فيه كتير، إنه عارض
+
+10
+00:01:05,180 --> 00:01:08,180
+للحالات اللي موجودة أو ناتج عنها الإصابة بيه قليلة
+
+11
+00:01:08,180 --> 00:01:11,320
+جدا، يعني في الفترة السابقة لم نسمع بالإصابة بهذا
+
+12
+00:01:11,320 --> 00:01:14,200
+الفيروس من سنوات عديدة، الولايات المتحدة في العام
+
+13
+00:01:14,200 --> 00:01:19,580
+2007 أعلنت أنها خالية من ال rapes اللي بسبب
+
+14
+00:01:19,580 --> 00:01:24,340
+الكلاب، أعلنتها rapes من نوع تاني، هتكلم عنهلكن
+
+15
+00:01:24,340 --> 00:01:28,720
+بسبب الكلاب انتهى ال rabies على حالات ال rabies في
+
+16
+00:01:28,720 --> 00:01:33,020
+العالم كله سنويا لا تتجاوز ال 50 ألف حالة طبعا
+
+17
+00:01:33,020 --> 00:01:36,460
+كلمة 50 ألف على مستوى سكان العالم هذا رقم ايه؟
+
+18
+00:01:36,460 --> 00:01:38,980
+يعني اللي بيموته من اللي اختناق و بيأكل و بيشربه
+
+19
+00:01:38,980 --> 00:01:43,500
+يمكن اكتر من 50 ألف لذا الرقم بيكون هذا رقم ضائع
+
+20
+00:01:43,500 --> 00:01:47,140
+طبعا هنقول اللي احنا ليش هو قل و ليش فيه صار تغيير
+
+21
+00:01:47,140 --> 00:01:49,620
+في ال epidemiology اذا احنا هالمرة حكينا المحاضرة
+
+22
+00:01:49,620 --> 00:01:51,340
+السابقة قد كلمنا عن التغيير في ال epidemiology
+
+23
+00:01:51,340 --> 00:01:56,360
+لهذا الفيروسالمعرض اسمه Rabies الفيروس من عائلة
+
+24
+00:01:56,360 --> 00:02:01,740
+اسمها Rabdovirus وهو الوحيد من هذه العائلة اللي له
+
+25
+00:02:01,740 --> 00:02:05,780
+أهمية طبية الباقين موجودين فيه أفراد أخرين لكن ليس
+
+26
+00:02:05,780 --> 00:02:10,400
+لهم أهمية طبيةبيحتوي على single-stranded RNA
+
+27
+00:02:10,400 --> 00:02:15,740
+enclosed .. housed by a bullet shape اللي هي الـ
+
+28
+00:02:15,740 --> 00:02:18,960
+capsid اللي شكل الرصاصة surrounded by a
+
+29
+00:02:18,960 --> 00:02:22,080
+lipoprotein envelope و انا اتفقنا انه هو helical
+
+30
+00:02:22,080 --> 00:02:27,080
+سمتري وبالتالي كل helical اصلا envelope virus
+
+31
+00:02:28,040 --> 00:02:32,880
+الجنوم نيجاتيف سنس وبالتالي يجب أن يحترق على RNA
+
+32
+00:02:32,880 --> 00:02:37,480
+dependent RNA polymerase ريبز فيروس has a single
+
+33
+00:02:37,480 --> 00:02:43,080
+antigenic type only one zero type يعني stableالـ
+
+34
+00:02:43,080 --> 00:02:46,820
+Antigenicity ناتجة عن الـ Spikes اللي موجودة على
+
+35
+00:02:46,820 --> 00:02:50,780
+الـ Glycoprotein زي باقي المجموعة اللي درسناهم
+
+36
+00:02:50,780 --> 00:02:54,360
+تمام؟ بس ماخصصناش، مابقلناش هو Hemagglutinin ولا
+
+37
+00:02:54,360 --> 00:02:57,980
+الـ Neuraminidase تمام؟ هو Spikes من نوع خاص، لكن
+
+38
+00:02:57,980 --> 00:03:03,740
+ال Immunity الناتجة هي ضد هذا الـ Antigen اللي
+
+39
+00:03:03,740 --> 00:03:08,140
+موجود على الـ Spikeهنا الميزة اللي بتميز فيها ده
+
+40
+00:03:08,140 --> 00:03:12,160
+الفيروس it has a very broad range of hosts يعني
+
+41
+00:03:12,160 --> 00:03:15,400
+بصيب الربيل اللي كنا نقول الإنسان الإنفلوانزا
+
+42
+00:03:15,400 --> 00:03:20,520
+الإنسان والخنزير والحصن والطيور البارع الإنفلوانزا
+
+43
+00:03:20,520 --> 00:03:24,000
+الإنسان وشوية حيوانات بعض الأواضع الأخرى موظف ما
+
+44
+00:03:24,000 --> 00:03:28,970
+كانت لمين فقط ده الإنسانبس هذا كل ال mammals
+
+45
+00:03:28,970 --> 00:03:33,950
+تقريبا يمكن أن تصاب، مين بيجيب يفسرلي ليش؟ و ياخد
+
+46
+00:03:33,950 --> 00:03:41,790
+26 على ال .. على الفسم و على العلامة تبعتهم؟ ايش
+
+47
+00:03:41,790 --> 00:03:45,070
+هو ال receptor؟ طب لمن يعطي اللي عالعابة هنا يا
+
+48
+00:03:45,070 --> 00:03:50,940
+عزيزي؟ بالنص، خلاصلأن الـ Receptor تبعه هو الـ
+
+49
+00:03:50,940 --> 00:03:54,600
+acetylcholine و الـ acetylcholine موجود في كل
+
+50
+00:03:54,600 --> 00:03:58,000
+المومالز و بتالي بالفعل يمكن لكن من بين هذه
+
+51
+00:03:58,000 --> 00:04:01,820
+المومالز شوية مومالز اللي ممكن تنقله للإنسان و
+
+52
+00:04:01,820 --> 00:04:07,940
+تكون ريزروار لهذا المرض العضة من ال rabid animal و
+
+53
+00:04:07,940 --> 00:04:10,820
+كلمة rabid animal يعني حيوان مصاب بال rabids أو
+
+54
+00:04:10,820 --> 00:04:14,620
+بدراء الكلب that manifests aggressive الذي يظهر
+
+55
+00:04:14,620 --> 00:04:19,850
+aggressive ادوانيةbiting behavior induced by the
+
+56
+00:04:19,850 --> 00:04:24,270
+viral encephalitis اللي بيخلّي الحيوان يظهر هذه
+
+57
+00:04:24,270 --> 00:04:28,650
+العدوانية ليست طبيعة هذا الحيوان العادية وإنما
+
+58
+00:04:28,650 --> 00:04:32,990
+إصابته بـ encephalitis يعني نقدر نقول إنه من الضغط
+
+59
+00:04:32,990 --> 00:04:35,530
+اللي موجود في الدماغ ومن الألم اللي موجود في
+
+60
+00:04:35,530 --> 00:04:39,710
+الدماغ بيفقد الحيوان قدرته على التمييز أو أن يكون
+
+61
+00:04:39,710 --> 00:04:42,490
+على طبيعته بتصرف بعدوانية كبيرة
+
+62
+00:04:46,380 --> 00:04:52,000
+في الولايات المتحدة معظم حالات ال rabies بتتم من
+
+63
+00:04:52,000 --> 00:04:54,820
+خلال ال wild animal ..الان كنت ميزه بين كلمة wild
+
+64
+00:04:54,820 --> 00:04:58,360
+animal و بين domestic animals ..الان الكلاب و
+
+65
+00:04:58,360 --> 00:05:01,880
+القطط في أوروبا و أمريكا هي domestic animals
+
+66
+00:05:01,880 --> 00:05:05,800
+..مظبوط؟ و ال .. ال .. ال racoon عاسم المثال
+
+67
+00:05:05,800 --> 00:05:08,660
+..الracoon اللي هو الحيوانة اللطيفة اللي له ديل
+
+68
+00:05:08,660 --> 00:05:11,960
+طويل مجطع حلقات هيك دي اللون أسود ..حنشوف صورة له
+
+69
+00:05:11,960 --> 00:05:16,370
+كمان شويةو في حاجة اسمها skunk، skunk اللي هو
+
+70
+00:05:16,370 --> 00:05:23,970
+الغبان، برضه حيوان شكله جميل لكن يطلق رائحة كريهة
+
+71
+00:05:23,970 --> 00:05:27,850
+كنوع من اللي هو الدفاع عن النفس و عنده شجاعة
+
+72
+00:05:27,850 --> 00:05:32,210
+مقاطعة النظير هذا الحيوان، يعني بيدخل على بيوت
+
+73
+00:05:32,210 --> 00:05:36,290
+الناس، مابيهتم لأي مخلوقات حتى لو شاف أسد جدامه
+
+74
+00:05:36,290 --> 00:05:40,910
+مابتفرج معاه، هذا اللي هو ال skunkRaccoons and
+
+75
+00:05:40,910 --> 00:05:45,590
+bats هذي هي الأكتر .. خلّيني أقول في الولايات
+
+76
+00:05:45,590 --> 00:05:51,030
+المتحدة الأكتر إحداثا للرايبس Dogs and cats are
+
+77
+00:05:51,030 --> 00:05:53,950
+frequently immunized and therefore are rarely
+
+78
+00:05:53,950 --> 00:05:57,110
+sources of human infection في السنوات الأخيرة
+
+79
+00:05:57,110 --> 00:06:03,030
+الخفافيش أصبحت مصدر لمعظم حالات ال human rabies في
+
+80
+00:06:03,030 --> 00:06:08,370
+الولايات المتحدةملاحظة القوارض والأبانب لا تقوم
+
+81
+00:06:08,370 --> 00:06:14,510
+بنقل اللي هو هذا المرض في نقطة كتير مهمة ال bats
+
+82
+00:06:14,510 --> 00:06:19,660
+أو الخفافيش ليس بالضرورة يا بنات انها تعدلكن هي
+
+83
+00:06:19,660 --> 00:06:24,560
+بتطير و هنشوف نقطة كتير مهمة في هذا الفيروس انه
+
+84
+00:06:24,560 --> 00:06:28,720
+اوكي هو بتكاتر في مكان العضة اللي هو في الجلد و في
+
+85
+00:06:28,720 --> 00:06:32,340
+ال nerve و بعدين بيطلع على ال central nervous
+
+86
+00:06:32,340 --> 00:06:37,280
+system بيضله يمشي لما يصل ل salivary glandبروح على
+
+87
+00:06:37,280 --> 00:06:40,780
+ال salivary gland وهناك بيعمل induction لل
+
+88
+00:06:40,780 --> 00:06:43,720
+salivation ال salivation اللي هو اللعاب ليش بيعمل
+
+89
+00:06:43,720 --> 00:06:46,480
+induction لل salivation عشان الفيروس يصير له
+
+90
+00:06:46,480 --> 00:06:50,240
+secretion مع اللي هو او عفوا الفيروس يكون مع ال
+
+91
+00:06:50,240 --> 00:06:54,660
+secretions عشان لما يهض اظن يهض من الفمه اللي وين
+
+92
+00:06:54,660 --> 00:06:58,640
+فيه اللعاب ففرصته في الانتقال للاخرين بتكون مالها
+
+93
+00:06:58,640 --> 00:07:05,730
+بتكون اعلى الآن الخفافيش بتهضشلكن و هي طايرة ال
+
+94
+00:07:05,730 --> 00:07:09,370
+saliva تبعتها أو ال secretions ممكن تطاير كرداد
+
+95
+00:07:09,370 --> 00:07:14,330
+وتصل إلى جروح أو تصل عبر الأنف يعني في تدخل إلى
+
+96
+00:07:14,330 --> 00:07:18,810
+جسم الإنسان هنا المشكلة الكبيرة اللي بتعرض ل
+
+97
+00:07:18,810 --> 00:07:24,330
+animal bite بيروح بزور الطبيب بس واحد ماتعرض ل
+
+98
+00:07:24,330 --> 00:07:29,000
+animal bite ليش يزور الطبيب؟ودلأسف الحالات اللى
+
+99
+00:07:29,000 --> 00:07:32,900
+تنتقل عن طريق الخفافيش لا يمكن تشخيصها إلا بعد
+
+100
+00:07:32,900 --> 00:07:37,780
+ظهور الأعراض وإذا ظهرت الأعراض على هذا المرض أو
+
+101
+00:07:37,780 --> 00:07:42,120
+بهذا المرض غالبا نسبة الوفيات كمان مرة بتصل إلى
+
+102
+00:07:42,120 --> 00:07:46,340
+100% طبعا مع تطور اللى حصل في موضوع ال life
+
+103
+00:07:46,340 --> 00:07:49,200
+supporting machines اللى هي الأجهزة أجهزة تنفذ
+
+104
+00:07:49,200 --> 00:07:53,580
+صناعية وخلافه في بعض الحالات survived لكن النسبة
+
+105
+00:07:53,580 --> 00:07:59,350
+الأعظم كمان مرةإذا الخفافيش ممكن تنقل إلينا اللي
+
+106
+00:07:59,350 --> 00:08:04,470
+هو ال rapes من خلال ال secretions وال saliva
+
+107
+00:08:04,470 --> 00:08:05,190
+تبعتها
+
+108
+00:08:08,140 --> 00:08:10,720
+هي بعض الصور هذا الـ skunk اللي حكينا عنه اللي هو
+
+109
+00:08:10,720 --> 00:08:14,040
+الظربان وهذا الرقون شايفين الحلقات اللي في الذهب
+
+110
+00:08:14,040 --> 00:08:17,440
+اللي طبعته؟ تمام؟ وطبعا الخطافيش ما هو أشكال
+
+111
+00:08:17,440 --> 00:08:21,540
+وأنواع كثيرة ومتنوعة في منها حجم يعني صغير خالص
+
+112
+00:08:21,540 --> 00:08:27,160
+وفي حجم يعني بيأكلوه في بعض القبائل الأفريقية طبعا
+
+113
+00:08:27,160 --> 00:08:30,000
+شوفوا القط هذا اللي مطلع عنا كلها لذبد من ال
+
+114
+00:08:30,000 --> 00:08:33,440
+saliva هذا الكلب rabid dog برضه بيطلع كمية كبيرة
+
+115
+00:08:33,440 --> 00:08:39,250
+من إيه؟ من ال saliva دلالة على إنهالفيروس وصل ال
+
+116
+00:08:39,250 --> 00:08:42,390
+salivary gland وعمل induction لمن؟ لل salivation
+
+117
+00:08:42,390 --> 00:08:47,030
+كوسيلة لل cycle تبعته انه ينتقل الى آخرين
+
+118
+00:08:49,620 --> 00:08:53,520
+Another rare example of transmission .. ذكرنا بعض
+
+119
+00:08:53,520 --> 00:08:57,000
+الحيوانات و ذكرنا ال bats مظبوط واحد من الأمثلة
+
+120
+00:08:57,000 --> 00:09:03,900
+النادرة نقل قرنية عين من متوفة لأسباب غير معروفة
+
+121
+00:09:03,900 --> 00:09:07,980
+واحد ميت تمام أسباب غير معروفة أهله جاله أنه ممكن
+
+122
+00:09:07,980 --> 00:09:12,100
+يكون organ donor organ donor يعني متبرع بالأعضاء
+
+123
+00:09:12,100 --> 00:09:16,820
+فأخد القرنية منه و زراوها لواحد تاني التاني اللي
+
+124
+00:09:16,820 --> 00:09:23,290
+زراو القرنية صار عنده rabiesإذن انتقلت من ال .. ال
+
+125
+00:09:23,290 --> 00:09:25,810
+.. ال organ transplant، احنا كتير من الأمراض اللي
+
+126
+00:09:25,810 --> 00:09:28,790
+ذكرناهم زي ال CMV و ال Epstein-Barr Virus يكونوا
+
+127
+00:09:28,790 --> 00:09:31,910
+بينتقلوا عبر ال organ transplantation، هاي كمان
+
+128
+00:09:31,910 --> 00:09:36,710
+واحد بينتقل عبر ال organ transplantationالان في
+
+129
+00:09:36,710 --> 00:09:41,810
+اللغة المتحدة لا يزيد عدد حالات ال .. ال rabies عن
+
+130
+00:09:41,810 --> 00:09:47,210
+عشر حالات سنويًا، 200 مليون او اكتر انسان عشر
+
+131
+00:09:47,210 --> 00:09:50,790
+حالات فقط، هذا رقم ايش ماله؟ رقم ضئيل، كمان مرة
+
+132
+00:09:50,790 --> 00:09:55,670
+اللي بيموتوا بحوادث ايش نسميها؟ حوادث بسكلتات اكتر
+
+133
+00:09:55,670 --> 00:09:59,090
+من اللي بيموتوا من هذا المرض، اذا ال rabies well
+
+134
+00:09:59,090 --> 00:10:02,940
+-controlled في ال western partالمشكلة ان حتى
+
+135
+00:10:02,940 --> 00:10:08,640
+الحلقات دولة غالبا مستوردين اما لامريكان كانوا
+
+136
+00:10:08,640 --> 00:10:13,120
+مسافرين برا ورجعوا او لأو ناس جايين يزوروا
+
+137
+00:10:13,120 --> 00:10:16,480
+الولايات المتحدة او مهاجرين الولايات المتحدة اذا
+
+138
+00:10:16,480 --> 00:10:19,320
+يعني زي ما حكينا فيه و ال control و ال control هذا
+
+139
+00:10:19,320 --> 00:10:25,340
+كان سبب الرئيسي شغلتان ال vaccination لل cats و ال
+
+140
+00:10:25,340 --> 00:10:29,290
+dogs رقم اتنينالـ Stray Dogs اللي هي الكلاب
+
+141
+00:10:29,290 --> 00:10:33,950
+الضالة، في مكافحة يعني شرسة في الولايات المتحدة
+
+142
+00:10:33,950 --> 00:10:37,250
+لكل الكلاب الضالة، فمانلاجيش كلاب في الشوارع إلا
+
+143
+00:10:37,250 --> 00:10:41,230
+إلها صاحب، إلها صاحب و تالي، مدام إلها صاحب عشان
+
+144
+00:10:41,230 --> 00:10:45,490
+تقتني كلب لابد أو قطة يجب أن تكون لديك شهادات
+
+145
+00:10:45,490 --> 00:10:49,450
+تطريم، زي ما بيقتن الإنسان إنسان، تمام؟ فيبقوا
+
+146
+00:10:49,450 --> 00:10:53,120
+فيها شهادات تطريم لهذه الحيواناتقولناكوا في 2007
+
+147
+00:10:53,120 --> 00:10:57,840
+تم الإعلان عن الولايات المتحدة خالية من ال rabies
+
+148
+00:10:57,840 --> 00:11:02,240
+مش أي rabies ال rabies اللي مسمين بسبب الكلاب اللي
+
+149
+00:11:02,240 --> 00:11:07,700
+هو بيسميه canine و canine معناها ناب ناب نابية
+
+150
+00:11:07,700 --> 00:11:12,580
+اللي هي من الكلاب و زي ما ذكرنا حوالي خمسين ألف
+
+151
+00:11:12,580 --> 00:11:17,320
+حالة سنويا بيصابوا بال rabies طبعا التوزيع
+
+152
+00:11:17,320 --> 00:11:22,170
+الجغرافي للخمسين ألف هو اللي بيفرجفي البلدان
+
+153
+00:11:22,170 --> 00:11:27,970
+العالم الثالث أكيد هيكون الوضع هنا أصعب من البلدان
+
+154
+00:11:27,970 --> 00:11:31,430
+العالم ال industrialized أو المتطورة ال virus
+
+155
+00:11:31,430 --> 00:11:34,930
+multiplies locally at the bite site and fix the
+
+156
+00:11:34,930 --> 00:11:39,490
+sensory neurons moves by axonal transport to the
+
+157
+00:11:39,490 --> 00:11:42,350
+central nervous system يعني بيتكاثر في مكان
+
+158
+00:11:42,350 --> 00:11:45,890
+الإصابة وبينتقل عبر اللي هو الجهاز العصبي لل
+
+159
+00:11:45,890 --> 00:11:50,200
+central nervous systemالان خلال عملية الانتقال من
+
+160
+00:11:50,200 --> 00:11:54,440
+مكان العضة لل central nervous system بيكون محمي،
+
+161
+00:11:54,440 --> 00:11:58,480
+ليش محمي؟ لأن هو جوا ال .. ال .. ال central
+
+162
+00:11:58,480 --> 00:12:04,100
+nervous system، وال immune system بيقدر عاليا ال
+
+163
+00:12:04,100 --> 00:12:06,940
+central nervous system، بيحاول قدر الإمكان ما
+
+164
+00:12:06,940 --> 00:12:12,490
+يجربش عليه، عارفين ليش؟انتوا بتعرفوا ان كتير من
+
+165
+00:12:12,490 --> 00:12:16,730
+الأمراض اللي احنا درسناهم، الضرر اللي حدث فينا كان
+
+166
+00:12:16,730 --> 00:12:19,710
+جارمين على ال immune system، فلو قلتلكم أنتوا
+
+167
+00:12:19,710 --> 00:12:22,650
+تخيلوا إذا قاطع الضوء الأخضر ال immune system
+
+168
+00:12:22,650 --> 00:12:26,830
+لمهاجمة ال neurons، إيش هيصير فينا؟ أي infection،
+
+169
+00:12:26,830 --> 00:12:30,790
+أي infection بسيطة بتصيب الجهاز العصبي تبعنا، جهاز
+
+170
+00:12:30,790 --> 00:12:34,540
+اللي بنا عبدالله هشطل عليها، فبديدمرالـ neurons
+
+171
+00:12:34,540 --> 00:12:38,460
+إذا دمر الـ neurons يعني شلل يعني خرف يعني فقدر
+
+172
+00:12:38,460 --> 00:12:42,480
+للسمع يعني مظبوط ولا لأ وبالتالي هو فهذا الفيروس
+
+173
+00:12:42,480 --> 00:12:46,280
+استغل هذا الوضع ودخل من خلال الـ central nervous
+
+174
+00:12:46,280 --> 00:12:52,780
+system لذلك طول فترة انتقاله من مكان العضة إلى الـ
+
+175
+00:12:52,780 --> 00:12:56,980
+central nervous system غالبا ما بيكون فيه مناعة أو
+
+176
+00:12:56,980 --> 00:13:01,420
+ردت فعل منعية وإن كان ردت فعل منعية بتكون ضعيفة
+
+177
+00:13:01,420 --> 00:13:02,340
+للغاية
+
+178
+00:13:05,210 --> 00:13:10,490
+هذه النقطة بدنا نسجلها في الذاكرة عشان نتكلم عن
+
+179
+00:13:10,490 --> 00:13:13,650
+اللي هو ال immunization أو ال vaccination بال
+
+180
+00:13:13,650 --> 00:13:15,150
+active وال passive immunization
+
+181
+00:13:19,600 --> 00:13:22,240
+الجملة التالتة بيقول الـ virus multiplies in the
+
+182
+00:13:22,240 --> 00:13:25,360
+central nervous system and then travels down the
+
+183
+00:13:25,360 --> 00:13:28,220
+peripheral nerve to the salivary gland and other
+
+184
+00:13:28,220 --> 00:13:31,000
+organs، لاحظوا هنا هملنا ال other organs، بقولنا
+
+185
+00:13:31,000 --> 00:13:34,740
+other organs، بس ركزت على مين؟ على salivary gland،
+
+186
+00:13:34,740 --> 00:13:40,240
+ليه أهميتها في معاودة نقل المرض لآخر؟from the
+
+187
+00:13:40,240 --> 00:13:43,100
+salivary gland it enters the saliva to be
+
+188
+00:13:43,100 --> 00:13:45,800
+transmitted by the bite الكلام اللي حكيناه مافيش
+
+189
+00:13:45,800 --> 00:13:50,360
+stage مؤشرة أنه الفيروس مابيصلش الدم وبالتالي
+
+190
+00:13:50,360 --> 00:13:53,740
+الردة الفعل المنعية اللي ذكرناها الضعيفة أحد
+
+191
+00:13:53,740 --> 00:13:58,220
+أسبابها أنه مافيش وصول للدم within the central
+
+192
+00:13:58,220 --> 00:14:02,100
+nervous system encephalitis develops سواء كان في
+
+193
+00:14:02,100 --> 00:14:06,310
+الحيوان أو في الإنسان في encephalitiswith the
+
+194
+00:14:06,310 --> 00:14:18,950
+death of neurons and demyelination Demyelination
+
+195
+00:14:18,950 --> 00:14:23,850
+يعني إزالتها، لما نقول demyelinating diseases هي
+
+196
+00:14:23,850 --> 00:14:26,670
+الأمراض اللي تؤدي إلى الخرف، الخرف يعني فقدان
+
+197
+00:14:26,670 --> 00:14:28,430
+العقل
+
+198
+00:14:42,080 --> 00:14:45,690
+النيرونات المصابةContains an eosinophilic
+
+199
+00:14:45,690 --> 00:14:48,010
+cytoplasmic تعرفهم inclusion اللي هو ماشي اسمهم
+
+200
+00:14:48,010 --> 00:14:51,890
+نجري bodies احنا درسنا تنتين inclusion bodies
+
+201
+00:14:51,890 --> 00:14:55,850
+مهمين اللي هم في ال CMV cytomegalovirus اللي
+
+202
+00:14:55,850 --> 00:14:59,210
+سميناهم owls eye و النجري body اللي كنا قاعدها في
+
+203
+00:14:59,210 --> 00:15:05,270
+ال rabies وهي diagnostic يعني markerbecause few
+
+204
+00:15:05,270 --> 00:15:11,750
+individuals have survived rapes يعني
+
+205
+00:15:11,750 --> 00:15:17,370
+الناس اللي أصيبوا بال rapes وشوفوا منه هم قلة هدول
+
+206
+00:15:17,370 --> 00:15:22,810
+القلة لم يتعرضوا لمرة أخرى rapes عشان نقدر نفهم
+
+207
+00:15:22,810 --> 00:15:27,830
+كيف المناه في المرة التانية غرب مايعرفشيعني مافيش
+
+208
+00:15:27,830 --> 00:15:31,910
+حد أصيب بال rapist و أصيب في مرة أخرى عشان نفهم
+
+209
+00:15:31,910 --> 00:15:37,070
+كيف ردت فعل المناعة في هذه الحالة
+
+210
+00:15:37,070 --> 00:15:45,970
+ال ink .. يعني هو .. يعني هو مرض ولا .. انه ردت
+
+211
+00:15:45,970 --> 00:15:48,850
+الفعل يعني ردت المناعة؟ لا احنا .. احنا ايش بنقول؟
+
+212
+00:15:48,850 --> 00:15:55,310
+بنقول ان لو افترض ان واحد عنده صار influenza تمام؟
+
+213
+00:15:56,140 --> 00:15:59,060
+وشو فيعمل ال influenza؟ المرة التانية صار اندو
+
+214
+00:15:59,060 --> 00:16:03,720
+انفلوانزا، إيش دور المناعة في مكافحة ال influenza
+
+215
+00:16:03,720 --> 00:16:07,260
+في المرة التانية؟ نجرب ندرسه، لإن هو اتعرض في
+
+216
+00:16:07,260 --> 00:16:09,560
+المرة الأولى، الآن في ال rabies مافيش حاجة إن
+
+217
+00:16:09,560 --> 00:16:13,380
+الناس اتعرضوا مرتين، اتعرض مرة ومافيش مرة اتعرض
+
+218
+00:16:13,380 --> 00:16:17,320
+تانية، فهم مش عارفين إيش التصرف تبقى لازم يكون لو
+
+219
+00:16:17,320 --> 00:16:23,460
+تعرض لهذا ال virus مرة أخرىفى نقطة هنا كتير مهمة
+
+220
+00:16:23,460 --> 00:16:25,580
+الـ incubation period اللى احنا نقشناها من بارحة
+
+221
+00:16:25,580 --> 00:16:28,540
+لما قولنا ليش بتختلف ال incubation period و ذكرنا
+
+222
+00:16:28,540 --> 00:16:33,000
+لكوا نموذج انه ال site of entry او المكان اللى عضى
+
+223
+00:16:33,000 --> 00:16:38,000
+تمام مثلا قولنا بتروح من أسبوعين إلى ست عشر أسبوع
+
+224
+00:16:38,000 --> 00:16:43,580
+نص شهر لقداش لأربع شهور تخيلوا أربع شهور ال
+
+225
+00:16:43,580 --> 00:16:50,780
+incubation period ست عشر أسبوع or longer أو أطول
+
+226
+00:16:51,790 --> 00:16:56,470
+الان مالذي يجعل هذا الفرق الكبير؟ احنا قولنا
+
+227
+00:16:56,470 --> 00:17:00,150
+مجموعة من العناصر المرة الماضية، نوع ال .. ال ..
+
+228
+00:17:00,150 --> 00:17:05,150
+ال .. الفيروس، صح؟ اتنين، مكان، الإصابة، تلاتة،
+
+229
+00:17:05,150 --> 00:17:08,970
+الدوس، الجرعة، والرابع يقولنا ال immunity، وإذا
+
+230
+00:17:08,970 --> 00:17:13,830
+كان في previous immunity عند الشخصهنا العامل الأهم
+
+231
+00:17:13,830 --> 00:17:16,090
+هو فيروس واحد عارفين احنا هو ال rabies و single
+
+232
+00:17:16,090 --> 00:17:19,550
+serotype مافيش فيه نوع مافيش فيه أنواع فمافيش هذا
+
+233
+00:17:19,550 --> 00:17:22,810
+ال variable مش موجود ال variable الوحيد هنا شغلتان
+
+234
+00:17:22,810 --> 00:17:26,690
+ال concentration of the virus with sight of bite
+
+235
+00:17:26,690 --> 00:17:30,710
+with sight of bite و ال depth of bite يعني لو كانت
+
+236
+00:17:30,710 --> 00:17:35,990
+superficialولا ديب تمام انتوا عارفين الحيوانات
+
+237
+00:17:35,990 --> 00:17:39,890
+يعني القطة غير عن الكلب مظبوط في الحجم الأنيعة
+
+238
+00:17:39,890 --> 00:17:44,470
+بتبعتها ومكان عمق اللي هو الدخول إذا هذه العوامل
+
+239
+00:17:44,470 --> 00:17:46,630
+هي اللي بتأثر على ال incubation period اللي بتكون
+
+240
+00:17:46,630 --> 00:17:51,330
+قصيرة لو كانت العضة في الرأس أو في منطقة الرأس
+
+241
+00:17:51,330 --> 00:17:53,910
+يعني في الأذن في الرقبة في الكاتف بيكون ال
+
+242
+00:17:53,910 --> 00:17:57,450
+incubation periodshort لو كانت في ال leg بتكون
+
+243
+00:17:57,450 --> 00:18:01,950
+الفترة انقبال طويل طبعا هذا اللي سمح لنا انه نتدخل
+
+244
+00:18:01,950 --> 00:18:06,210
+قبل ظهور العرض ان في عندنا انقبال طويل المثالين
+
+245
+00:18:06,210 --> 00:18:08,710
+اللي ذكرناهم في ال active passive immunization و
+
+246
+00:18:08,710 --> 00:18:12,750
+ال post exposure كانت الفكرة فيهم ان ال 10 10 have
+
+247
+00:18:12,750 --> 00:18:16,480
+long incubation periodClinically, the patient
+
+248
+00:18:16,480 --> 00:18:19,960
+exhibits a prodrome of non-specific symptoms, such
+
+249
+00:18:19,960 --> 00:18:24,060
+as fever, anorexia, and changes in sensation at
+
+250
+00:18:24,060 --> 00:18:25,520
+the bite site.
+
+251
+00:18:31,080 --> 00:18:37,640
+Within a few days, signs such as confusionمين أنت؟
+
+252
+00:18:37,640 --> 00:18:42,740
+ينسى، مايركزش، هذا اسمه confusion الآن التانية ال
+
+253
+00:18:42,740 --> 00:18:46,440
+lethargy اللي هو الخمول قد نجد إنسان .. قد نجد
+
+254
+00:18:46,440 --> 00:18:54,220
+إنسان متقطق الرأس شبه نايم و هو جاعد تمام ماعندوش
+
+255
+00:18:54,220 --> 00:18:58,900
+الحركة العادية تبع الأشخاص حتى لو كان مريض مرض آخر
+
+256
+00:18:58,900 --> 00:19:03,020
+ممكن يتحرك و يتكلم زي ال influenza لكن لما بيقول
+
+257
+00:19:03,020 --> 00:19:08,790
+lethargic يعني خاملهذه نية ما بيعمل الحركات
+
+258
+00:19:08,790 --> 00:19:14,590
+الطبيعية تبع الإنسان اللي بعملها بشكل طبيعي جونا
+
+259
+00:19:14,590 --> 00:19:17,790
+lethargy and increased salivation اللي هو زيادة في
+
+260
+00:19:17,790 --> 00:19:23,030
+إنتاج اللعب most notable وهذه ملاحظة يعني برضه
+
+261
+00:19:23,030 --> 00:19:29,070
+مميزة اللي هو القلم عند البلاءو هذا بيولد .. القلم
+
+262
+00:19:29,070 --> 00:19:33,130
+عند البلاء بيولد عند المرضى الخوف من الماء بيسموه
+
+263
+00:19:33,130 --> 00:19:36,330
+hydrophobia انه بيصير خاف من الميه لإن الميه
+
+264
+00:19:36,330 --> 00:19:40,130
+بتمثله الشيء اللي بيشربه و لو بيشربه بيبلعه برضه
+
+265
+00:19:40,130 --> 00:19:43,430
+مظبوط فمؤلم جدا بيكون وبالتالي بيصير عنده
+
+266
+00:19:43,430 --> 00:19:48,010
+hydrophobia within several days the disease
+
+267
+00:19:48,010 --> 00:19:52,750
+progressed to seizure يعني تشنجات ممكن يصير في شرل
+
+268
+00:19:52,750 --> 00:19:57,520
+و ممكن يصل لكومةإذا وصل الكومة، غالباً بيقولنا الـ
+
+269
+00:19:57,520 --> 00:20:04,080
+death almost invariably ensue، يعني بيتبع هذا
+
+270
+00:20:04,080 --> 00:20:11,880
+الأعراض، بيتبع ما هو الموت، but with the advent of
+
+271
+00:20:11,880 --> 00:20:14,740
+life support system, a few individuals have
+
+272
+00:20:14,740 --> 00:20:20,300
+survivedمع وجود الأجهزة الحديثة اللى بتدعم الحياة
+
+273
+00:20:20,300 --> 00:20:23,240
+زى أجهزة تنافس صناعى بعض المرضى حتى اللى يروح
+
+274
+00:20:23,240 --> 00:20:28,260
+عليهم أعراض ممكن يعني ينجوا من هذا المرضى طبعا مش
+
+275
+00:20:28,260 --> 00:20:34,040
+بدون علاج بعلاج تمام؟ والبعض الآخر مع وجود العلاج
+
+276
+00:20:34,040 --> 00:20:36,820
+اللى هو ال vaccine و ال immunoglobulin برضه
+
+277
+00:20:36,820 --> 00:20:42,400
+بيموتوا مدى ان ظهرت هذه الأعراضالـ lab diagnosis
+
+278
+00:20:42,400 --> 00:20:53,560
+قلنا لكوا ان الانسان
+
+279
+00:20:53,560 --> 00:20:57,660
+اللي
+
+280
+00:20:57,660 --> 00:21:02,720
+يسبب الأذى هو الحيوان اللي يجيبه معاناهنجيب معانا
+
+281
+00:21:02,720 --> 00:21:08,100
+في المستشفيات إذا صار في report إنه حد تعرض لعدة
+
+282
+00:21:08,100 --> 00:21:11,860
+مش هنا برا إن هنا بممكن الأهالي يساعدوا في هذا
+
+283
+00:21:11,860 --> 00:21:15,880
+الموضوع إنه والله في كلب بلفل في المنطقة هذه هو
+
+284
+00:21:15,880 --> 00:21:19,320
+اللي عض هذا الشخص جيبوه و ادوه على المستشفى عشان
+
+285
+00:21:19,320 --> 00:21:22,980
+يراقبوا ال behavior تبع الكلب هذا واحد اتنين ممكن
+
+286
+00:21:22,980 --> 00:21:27,180
+ناخده منه عينات من الدماغ و نعمل فحص نشوف نجري
+
+287
+00:21:27,180 --> 00:21:31,540
+bodies إذا الحيوان مصابلازم المريض ياخد active
+
+288
+00:21:31,540 --> 00:21:37,380
+passive immunization هذا لما يكون dogs في الولايات
+
+289
+00:21:37,380 --> 00:21:40,940
+المتحدة انها مقارنة بتقول لو كان wild animal وال
+
+290
+00:21:40,940 --> 00:21:45,370
+animal غذب مش هنقدر نمسكهفسواء مصاب ولا مش مصاب،
+
+291
+00:21:45,370 --> 00:21:49,270
+مدام العضة من .. من wild animal تمام؟ وفي نقطة هنا
+
+292
+00:21:49,270 --> 00:21:53,830
+ممكن يعني برضه ال .. الأطباء يسألوها للمريض، هل
+
+293
+00:21:53,830 --> 00:21:59,610
+اتعرضت للعدد دون ما سابق انذار ولا كان فيه بينك
+
+294
+00:21:59,610 --> 00:22:04,660
+وبين الحيوان أخدعطة؟ كيف أخدعطة يعني؟يعني انت
+
+295
+00:22:04,660 --> 00:22:08,420
+عملتله provoke، انت استفرته، انت استفزيته، ضربت
+
+296
+00:22:08,420 --> 00:22:12,460
+عليه حجر، مساكت عليه عصاية، حاولت تأذيه، هذا اسمه
+
+297
+00:22:12,460 --> 00:22:18,600
+provoke، provoke يعني استفز الحيوانمن طباعة
+
+298
+00:22:18,600 --> 00:22:22,320
+الحيوانات العادية، أنا ما بتهجم على الإنسان بشكل
+
+299
+00:22:22,320 --> 00:22:26,940
+زي الكلاب والقطر إلا إذا استفزها واحد أو حاول إنه
+
+300
+00:22:26,940 --> 00:22:30,840
+يأذيها فالقرار إنه نعطي أو ما نعطيش معتمد على
+
+301
+00:22:30,840 --> 00:22:33,800
+مجموعة من العوامل اللي هنمر عليها في نهاية اللي هو
+
+302
+00:22:33,800 --> 00:22:36,820
+المحاضرة لما نتكلم عن ال treatment أو ال
+
+303
+00:22:36,820 --> 00:22:40,280
+prevention المهم إنه احنا بنقول إن ال diagnosis
+
+304
+00:22:40,280 --> 00:22:45,060
+مرتبط برضه بمين بالحيوان اللي موجود أو اللي سبب
+
+305
+00:22:45,060 --> 00:22:49,130
+الأذىنجري bodies في الـ cytoplasmic inclusions
+
+306
+00:22:49,130 --> 00:22:55,370
+للنيرونات تبع الحيوان وجودها هذا diagnostic marker
+
+307
+00:22:55,370 --> 00:22:59,530
+مهم جدا في ال rabies الفيروس could be isolated
+
+308
+00:22:59,530 --> 00:23:03,290
+from the animal brain by growing in cell culture
+
+309
+00:23:03,290 --> 00:23:08,070
+لكن للأسف هذا بياخد وجه طويل وهذا بيعيق القرار انه
+
+310
+00:23:08,070 --> 00:23:11,690
+نعطي او ما نعطيش اللي هو ال active passive
+
+311
+00:23:11,690 --> 00:23:16,400
+immunizationالرايبز من ال human يعني لو واحد ضحط
+
+312
+00:23:16,400 --> 00:23:21,580
+عليها عراض وشاكين انها رايبز مابناخدلهوش brain
+
+313
+00:23:21,580 --> 00:23:25,320
+مابناخدلهوش brain cells ايش ممكن ناخدله؟ مابناخدله
+
+314
+00:23:25,320 --> 00:23:30,860
+skin من منطقة الرقبة وين منبت الشعر في الرقبة
+
+315
+00:23:30,860 --> 00:23:36,240
+بناخد biopsy و بنعملها staining و بنشوف اذا كان
+
+316
+00:23:36,240 --> 00:23:39,860
+فيها اما باستخدام ال fluorescent labels antibody
+
+317
+00:23:39,860 --> 00:23:42,300
+او باستخدام ال staining العادى عشان نشوف اللي هو
+
+318
+00:23:42,300 --> 00:23:47,840
+النجري bodiesيبقى ال skin of the neck at the
+
+319
+00:23:47,840 --> 00:23:48,800
+hairline
+
+320
+00:23:52,160 --> 00:23:54,580
+isolation of the virus from sources such as
+
+321
+00:23:54,580 --> 00:23:58,440
+saliva, spinal fluid and brain tissue برضه موجودة
+
+322
+00:23:58,440 --> 00:24:02,600
+ارتفاع في ال antibody tighter نجري bodies can be
+
+323
+00:24:02,600 --> 00:24:06,140
+demonstrated from corneal scrapping تذكروا قبل
+
+324
+00:24:06,140 --> 00:24:11,960
+قليل قلنا لكوا انه في احد الحالات اللي تم احداث ال
+
+325
+00:24:11,960 --> 00:24:15,140
+rabies من خلالها هو نقل الكورنيا فالكورنيا بيحتوى
+
+326
+00:24:15,140 --> 00:24:18,580
+على ال virus وبالتالي ممكن نعمل corneal scrapping
+
+327
+00:24:18,580 --> 00:24:24,210
+وفي حالة الوفاةبعد موت الإنسان لأ بقص إنك تاخد منه
+
+328
+00:24:24,210 --> 00:24:27,630
+عينا من الدماغ تبقى أو حتى اللي هو طالع أنه أنا
+
+329
+00:24:27,630 --> 00:24:31,850
+الآن هو إنسان ميت، إيش بنسمي العينا من الميت؟
+
+330
+00:24:31,850 --> 00:24:37,270
+Autopsy، تمام؟ Autopsy There is no antiviral
+
+331
+00:24:37,270 --> 00:24:40,590
+therapy for patients with rabies، مافي أن علاج
+
+332
+00:24:40,590 --> 00:24:45,230
+نكافح فيه هذا الفيروس، only supportive treatment،
+
+333
+00:24:45,230 --> 00:24:48,990
+إيش يعني supportive treatment؟يعني عنده seizure
+
+334
+00:24:48,990 --> 00:24:53,810
+بنعطيه Anti-epileptic، عنده مثلا نقص في التنفس
+
+335
+00:24:53,810 --> 00:24:57,090
+بنحط له Oxygen زيادة، عنده ارتفاع في الحرارة،
+
+336
+00:24:57,090 --> 00:25:01,650
+مسكنات، هذا اسمه supportive treatment، ليس علاج لل
+
+337
+00:25:01,650 --> 00:25:06,590
+disease نفسهلـ prevention there are two approaches
+
+338
+00:25:06,590 --> 00:25:11,230
+to prevention of rabies in human واحد الـ pre
+
+339
+00:25:11,230 --> 00:25:15,410
+exposure and post exposure طبعا ال pre exposure هو
+
+340
+00:25:15,410 --> 00:25:19,470
+السياسة العامة السياسة العامة اللي متابعها أصلا في
+
+341
+00:25:19,470 --> 00:25:22,990
+كل ال vaccination لكن يا هلطر عشان خمسين ألف واحد
+
+342
+00:25:22,990 --> 00:25:26,230
+في كل العالم بينصوا بال rabies انطعم كل سكان
+
+343
+00:25:26,230 --> 00:25:31,010
+العالم مش منطقي ولا لأ فعليش نلجأ لمن؟ نلجأ لل ..
+
+344
+00:25:32,690 --> 00:25:36,410
+للفئات الأكثر عرضة للإصابة بال rapes مين مثلا
+
+345
+00:25:36,410 --> 00:25:41,510
+لطباء البيطاريين المسجود اللي عاملين في حدوق
+
+346
+00:25:41,510 --> 00:25:45,730
+الحيوان أو الناس اللي بيسافروا إلى أماكن موبوعة
+
+347
+00:25:45,730 --> 00:25:51,130
+هدولة بيعملهم pre exposure جبل ما يتعرض بيقولوا
+
+348
+00:25:51,130 --> 00:25:54,490
+أنت ممنوع تعمل هذه الوظيفة أو تشتغل هذه الوظيفة
+
+349
+00:25:54,490 --> 00:25:59,700
+إلا تاخد هذا ال vaccineمتفقين عليها؟ إذا مين هم؟
+
+350
+00:25:59,700 --> 00:26:03,360
+Veterinarians، Zoo keepers اللي هم اللي عاملين في
+
+351
+00:26:03,360 --> 00:26:07,040
+حدوقة الحيوانات و Travelers to areas of
+
+352
+00:26:07,040 --> 00:26:09,460
+hyperendemic infection يعني بيكون المرض فيها
+
+353
+00:26:09,460 --> 00:26:14,440
+مستوطن بشكل كبير الـ Pre exposure immunization
+
+354
+00:26:14,440 --> 00:26:18,500
+consists of three doses تُعطى على صفر، صفر يعني
+
+355
+00:26:18,500 --> 00:26:22,940
+الأن، لحظة، هذه اللحظة، سبع أيام، واحد وعشرين أو
+
+356
+00:26:22,940 --> 00:26:27,760
+تمانية وعشرينيعني هاد ماشي أربع جولات صار تلاتة بس
+
+357
+00:26:27,760 --> 00:26:30,460
+بدل الواحد و عشرين ممكن نبدلها منين تمانية و عشر
+
+358
+00:26:30,460 --> 00:26:36,660
+ال booster dose are given as needed اش يعني as
+
+359
+00:26:36,660 --> 00:26:41,060
+given .. are given as needed يعني تقطع بحسب الحاجة
+
+360
+00:26:41,060 --> 00:26:45,160
+اش يعني بحسب الحاجة واحد بطل يشتغل في ال .. في
+
+361
+00:26:45,160 --> 00:26:50,140
+الحديقة الحيواني هل في داعي ان هو على طبع كل فترة
+
+362
+00:26:50,140 --> 00:26:56,150
+عمله booster dose طب واحد ضل يشتغل كل أكم سنةفيه
+
+363
+00:26:56,150 --> 00:26:59,330
+لاجوا variation بين الناس في ال response لل
+
+364
+00:26:59,330 --> 00:27:02,470
+immunization فاكر لك إذا كان بقى اللي عنده
+
+365
+00:27:02,470 --> 00:27:06,730
+antibody tighter أقل من واحد إلى خمسة اعطيه poster
+
+366
+00:27:06,730 --> 00:27:11,070
+dose إذا واحد إلى خمسة وفج تعطيهوش poster dose
+
+367
+00:27:11,070 --> 00:27:14,470
+بمعنى إنه حدد ال tighter أو التركيز تبع ال
+
+368
+00:27:14,470 --> 00:27:19,210
+antibody تركيز أقوى ال antibody below which you
+
+369
+00:27:19,210 --> 00:27:24,550
+should be exposed to a poster dose
+
+370
+00:27:27,370 --> 00:27:30,090
+The rabies vaccine is the only vaccine that is
+
+371
+00:27:30,090 --> 00:27:32,230
+routinely used post-exposure.
+
+372
+00:27:58,450 --> 00:28:02,130
+The long incubation period of the disease allows
+
+373
+00:28:02,130 --> 00:28:05,490
+the virus in the vaccine sufficient time to induce
+
+374
+00:28:05,490 --> 00:28:09,690
+protective immunity. إذن هي بالفعل الـ incubation
+
+375
+00:28:09,690 --> 00:28:14,270
+period الطويلة التي سمحت لنا أو سمحت للفاكسين أنه
+
+376
+00:28:14,270 --> 00:28:21,210
+يعطي immunity كافية للتخلص من الفيروس ال post
+
+377
+00:28:21,210 --> 00:28:22,730
+exposure immunization
+
+378
+00:28:26,280 --> 00:28:32,840
+وهو ريبز اميونو جلوبيليم، من اين حصلنا عليه؟ من
+
+379
+00:28:32,840 --> 00:28:34,380
+شخصين شخصيين اللي هم الـ hyper immunized
+
+380
+00:28:37,920 --> 00:28:42,360
+اما و ناس أصيبوا في السابق و أعطوا vaccine او
+
+381
+00:28:42,360 --> 00:28:46,280
+volunteers او مُتطوعين طبعا كلمة مُتطوعين يعني
+
+382
+00:28:46,280 --> 00:28:51,780
+غالبا مافيش تطوع مجاني يعني غالبا فيه خلينا نقول
+
+383
+00:28:51,780 --> 00:28:56,140
+مزايا تُعطى فاسمهم مُتطوعين وهذا كانت تطوع وهذا
+
+384
+00:28:56,140 --> 00:29:00,260
+شراء و هذا شراء زي ما أقولكوا اللي بتطوع بيعطيه
+
+385
+00:29:00,260 --> 00:29:05,320
+خمس علامات صارت تطوع ومع ذلك لو جيناكوا تطوع بخمس
+
+386
+00:29:05,320 --> 00:29:06,040
+علامات بتطوع ولا
+
+387
+00:29:09,560 --> 00:29:12,760
+طيب plus immediate cleaning of the wound يعني
+
+388
+00:29:12,760 --> 00:29:16,480
+تطهير الجرح برضه كمان عملية مهمة جدا في هذه الحالة
+
+389
+00:29:16,480 --> 00:29:20,200
+and this is an example of active passive
+
+390
+00:29:20,200 --> 00:29:23,640
+immunization tetanus immunization should also be
+
+391
+00:29:23,640 --> 00:29:30,060
+considered لأنه زي ما احنا بنقول انه ال ال
+
+392
+00:29:33,160 --> 00:29:37,240
+الأشياء الصادقة أو الملوثة بالتربة قد تنقل
+
+393
+00:29:37,240 --> 00:29:41,720
+تيتانوس، أيضًا بعض الحيوانات قد تنقل أيضًا
+
+394
+00:29:41,720 --> 00:29:42,440
+التيتانوس
+
+395
+00:29:46,990 --> 00:29:51,390
+باسيف امينيتي او اكتف امينيتي لان احنا جالبا كلنا
+
+396
+00:29:51,390 --> 00:29:55,630
+متعامل ضد تتانوس فيكفي نعطي تكسيت عشان نعمل
+
+397
+00:29:55,630 --> 00:30:00,010
+induction ل secondary response وبيعطي immediate
+
+398
+00:30:00,010 --> 00:30:04,130
+response لل antibodies ضد تتانوس، اذا تتانوس و
+
+399
+00:30:04,130 --> 00:30:07,450
+rabies ممكن ينتقلوا بنفس اللي هو الوسيلة
+
+400
+00:30:10,740 --> 00:30:15,220
+القرار أن نقوم بإعطاء post exposure immunization
+
+401
+00:30:15,220 --> 00:30:19,400
+بيتمد على مجموعة من الأوامر كما ذكرنا قبل قليل The
+
+402
+00:30:19,400 --> 00:30:23,880
+type of animal إذا كان wild أو domestic قلنالكوا
+
+403
+00:30:23,880 --> 00:30:28,940
+all wild animals demands immunization العبّة من
+
+404
+00:30:28,940 --> 00:30:34,160
+حيوان بري تتطلب تمنيع تمنيع اللي هو ال active
+
+405
+00:30:34,160 --> 00:30:38,300
+immunizationWhether an attack by a domestic animal
+
+406
+00:30:38,300 --> 00:30:41,520
+was provoked، قلنا لكوا كلمة provoked يعني تم
+
+407
+00:30:41,520 --> 00:30:45,060
+استفزازه، إذا تم استفزازه مع الحكي أنه غالبا مش
+
+408
+00:30:45,060 --> 00:30:49,520
+هيكون بسبب ال rapist، هو عضمة، عضمة بسبب أنه يدفع
+
+409
+00:30:49,520 --> 00:30:54,550
+عن نفسهwhether the animal was immunized adequately
+
+410
+00:30:54,550 --> 00:30:58,290
+إذا كان الحيوان نفسه اللي ستسبب بالعدة هل كان هو
+
+411
+00:30:58,290 --> 00:31:02,330
+مطعم ولا غير مطعم and whether the animal is
+
+412
+00:31:02,330 --> 00:31:06,790
+available to be observed هل الحيوان متوفر موجود؟
+
+413
+00:31:06,790 --> 00:31:13,750
+انت بتعرفه في موضوع الحياة، الثعابين، لو واحد
+
+414
+00:31:13,750 --> 00:31:17,490
+جرسته حياةانتوا عارفين ان فين ده؟ احنا انواع
+
+415
+00:31:17,490 --> 00:31:21,270
+الثعابين و الحياة، و السبوم تبعتها انواع، غالبا كل
+
+416
+00:31:21,270 --> 00:31:24,570
+دولة بيكون عندها registry في كل .. في انواع
+
+417
+00:31:24,570 --> 00:31:27,550
+الثعابين و عندها antivenom، antivenom يعني
+
+418
+00:31:27,550 --> 00:31:30,450
+antibody ضد مين، ضد السم تبعت هذه الثعابين ..
+
+419
+00:31:30,450 --> 00:31:35,690
+الثعابين، اليوم لما انا واحد يصير عنده عبد ثابان،
+
+420
+00:31:35,690 --> 00:31:41,270
+طبعا الثابان إلو marksقد تكون واضحة و قد لا تكون
+
+421
+00:31:41,270 --> 00:31:46,150
+واضحة ال marks هذه في المكان العضة قد تكون مميزة
+
+422
+00:31:46,150 --> 00:31:50,570
+للثوبان و قد لا تكون مميزة للثوبان الوسيلة الأمثل
+
+423
+00:31:50,570 --> 00:31:54,490
+عشان انا اعطي antitoxin antivenom تمام امثل ان
+
+424
+00:31:54,490 --> 00:32:00,390
+نجيب الثوبان اللي اللي تسبب بالعضة طبعا مش معقول
+
+425
+00:32:00,390 --> 00:32:05,130
+لنفس الشخص اللي لكن ممكن يعطي هو ال location
+
+426
+00:32:05,130 --> 00:32:10,810
+الجيографي و فيبيكونوا مسئولين في كل منطقة عن
+
+427
+00:32:10,810 --> 00:32:14,170
+الحياة البرية، هم اللي بيروحوا يدوروا على هذا
+
+428
+00:32:14,170 --> 00:32:17,750
+الثابتإذا أحضروا للطبيب وعرفت الطبيب أن هو
+
+429
+00:32:17,750 --> 00:32:22,130
+الثرابان، بصير سهل جدا عملية المعالجة، وبالتالي
+
+430
+00:32:22,130 --> 00:32:27,450
+نفس الجثة نقول أن أفضل وسيلة أن نتعرف على أن العضة
+
+431
+00:32:27,450 --> 00:32:32,430
+هذه تستوجب ال immunization نجيب اللي هو الحيوان
+
+432
+00:32:32,430 --> 00:32:36,310
+اللي تسبب بهذه العضة، وعن برة قلت لكم كمان اللي هو
+
+433
+00:32:36,310 --> 00:32:41,580
+المكافحةال .. ال stray dogs او الكلاب الضالة يعني
+
+434
+00:32:41,580 --> 00:32:44,460
+هي مؤسسة عندهم باعتبارها مؤسسة ضخمة و كبيرة و تقعد
+
+435
+00:32:44,460 --> 00:32:48,260
+على تلقل في الشوارع فمن السهل جدا انه برضه تبلغ و
+
+436
+00:32:48,260 --> 00:32:51,280
+يحضروا هذه الحيارة طبعا احنا عندنا هذا الكلام
+
+437
+00:32:51,280 --> 00:32:56,200
+مابوصيل whether rabies is endemic in the area يعني
+
+438
+00:32:56,200 --> 00:32:58,640
+احنا في غزر مابوصيل لان اصلا احنا ماعناش rabies
+
+439
+00:32:58,640 --> 00:33:01,800
+يعني احنا من سنوات طويلة لم نسمع بان في عندنا حالة
+
+440
+00:33:01,800 --> 00:33:08,910
+من حالات ال rabies في قطاع عظمإذا قررنا إنه بنعمل
+
+441
+00:33:08,910 --> 00:33:13,110
+immunization both human-deployed cell vaccine
+
+442
+00:33:13,110 --> 00:33:18,270
+الويروس
+
+443
+00:33:18,270 --> 00:33:27,890
+تم تنميته على human-deployed cell culture and
+
+444
+00:33:27,890 --> 00:33:29,590
+reg are recommended
+
+445
+00:33:34,840 --> 00:33:42,160
+Five doses of HDCV are given on day 0, 3, 7, 14
+
+446
+00:33:42,160 --> 00:33:49,420
+and 28 يبقى فاكرين في الأول كم جرعة كانوا الـ Pre
+
+447
+00:33:49,420 --> 00:33:55,800
+كانوا تلاتة هنا خمس جرعات صفر تلاتة سبعة اربعتاش
+
+448
+00:33:55,800 --> 00:33:59,180
+تمانعاشين والريج اللي هو ال rabies immunoglobulin
+
+449
+00:33:59,180 --> 00:34:04,200
+يُعطى مرة واحدة فقط لبناتفي نفس اليوم اللي بنعطيه
+
+450
+00:34:04,200 --> 00:34:07,220
+الجرعة الأولى، اللي هو الـ Zero Day، اللي هو يعني
+
+451
+00:34:07,220 --> 00:34:10,800
+اليوم الأول، تمام؟ مابنعطيهوش على فترات، بنعطيه
+
+452
+00:34:10,800 --> 00:34:14,980
+مرة واحدة، وين بنحقنه؟ بنحقنه في مكان الإصابة
+
+453
+00:34:14,980 --> 00:34:19,860
+نفسها، وهذا المشكلة لو كان الشخص قد تعرض لعدة
+
+454
+00:34:19,860 --> 00:34:25,200
+إصابات مختلفة في دسمورك، هذا المشكلة فبتنوزع الـ
+
+455
+00:34:25,200 --> 00:34:28,980
+Immunoglobulin على المناطق المختلفة من هذه العدة،
+
+456
+00:34:28,980 --> 00:34:33,070
+برضه مش هذه القصةالقصة الأخطر ان هو بده يحط ال
+
+457
+00:34:33,070 --> 00:34:35,970
+vaccine يعني انا بقول انه دايما ال vaccine بده
+
+458
+00:34:35,970 --> 00:34:39,670
+يكون في منطقية بعيدة عن المناطق اللي حطيت فيها ال
+
+459
+00:34:39,670 --> 00:34:44,050
+immunoglobulin فهذه تماما مشكلة لكن في الآخر I
+
+460
+00:34:44,050 --> 00:34:47,470
+have no choice but to give the two لازم نعطي اتنين
+
+461
+00:34:47,470 --> 00:34:49,410
+مع بعض
+
+462
+00:34:52,970 --> 00:34:59,770
+As much as possible of the rig is
+
+463
+00:34:59,770 --> 00:35:03,590
+given into the bite site and the reminder is given
+
+464
+00:35:03,590 --> 00:35:04,650
+intramuscular
+
+465
+00:35:17,860 --> 00:35:20,240
+If the animal has been captured, it should be
+
+466
+00:35:20,240 --> 00:35:23,340
+observed for 10 days and observed if symptoms
+
+467
+00:35:23,340 --> 00:35:26,680
+develop برضه كمان هذه نقطة من النقاط لـ Prevention
+
+468
+00:35:26,680 --> 00:35:30,480
+عشان احنا ناخد القرار اما نعدم الحيوان او ما
+
+469
+00:35:30,480 --> 00:35:33,960
+نعدموش برضه هذه نقطة مهمة The brain of the animal
+
+470
+00:35:33,960 --> 00:35:36,700
+should be examined by immunofluorescence كلمة
+
+471
+00:35:36,700 --> 00:35:39,740
+immunofluorescence يعني antibody labelled with
+
+472
+00:35:39,740 --> 00:35:43,470
+اللي هو FluoresceinThe vaccine for immunization of
+
+473
+00:35:43,470 --> 00:35:48,090
+dogs and cats consists of inactivated rabies virus
+
+474
+00:35:57,280 --> 00:36:01,160
+The first immunization is usually given at three
+
+475
+00:36:01,160 --> 00:36:06,840
+months of age، تلت شهور من حياة الحيوان، with a
+
+476
+00:36:06,840 --> 00:36:11,080
+booster dose either given annually يعني كل سنة أو
+
+477
+00:36:11,080 --> 00:36:15,340
+at three years interval، طبعا برضه كمان مرة، في
+
+478
+00:36:15,340 --> 00:36:19,210
+فرج كبير بين كلمة سنة و كل تلت سنينit depends upon
+
+479
+00:36:19,210 --> 00:36:22,890
+the type of animal يعني ال veterinary هو اللي
+
+480
+00:36:22,890 --> 00:36:30,310
+بيقرر هل نعطل حكمة سنويا ولا كل ثلاث سنوات الفيروس
+
+481
+00:36:30,310 --> 00:36:33,110
+اللي هيكون معنا المرة القادمة ان شاء الله هو human
+
+482
+00:36:33,110 --> 00:36:37,630
+T cell lymphotropic virus وهذا الفيروس اللي
+
+483
+00:36:37,630 --> 00:36:43,570
+بيطلعلنا خلايا جميلة لكنها خلايا سلطانية نختم فيها
+
+484
+00:36:43,570 --> 00:36:49,800
+الصورة المحاضرتناعشان المرة الجاية نكون عارفين الـ
+
+485
+00:36:49,800 --> 00:36:54,040
+flower shaped cells اللي بنشوفها في ال blood
+
+486
+00:36:54,040 --> 00:36:56,940
+اسمها، نراكم ان شاء الله المرة القادمة
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0.srt
new file mode 100644
index 0000000000000000000000000000000000000000..64b098b8f2662e9a68354c8c1c508acabb2c8938
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0.srt
@@ -0,0 +1,2283 @@
+1
+00:00:20,990 --> 00:00:23,930
+فبسم الله الرحمن الرحيم اليوم موضوع جديد إن شاء
+
+2
+00:00:23,930 --> 00:00:28,550
+الله متعلق بالـ RNA non-enveloped viruses وهي 
+
+3
+00:00:28,550 --> 00:00:33,010
+مجموعة أقل من التي سبقتها لكن بنركز فيها على 
+
+4
+00:00:33,010 --> 00:00:36,650
+مجموعة غالبا ما تصيب الـ gastrointestinal tract
+
+5
+00:00:36,650 --> 00:00:39,770
+البعض منها طبعا بصيب أماكن أخرى زي الـ rhino virus
+
+6
+00:00:39,770 --> 00:00:43,170
+لكن المعظم بيأثر على الـ gastrointestinal tract
+
+7
+00:00:43,170 --> 00:00:45,630
+الآن التأثير على الـ gastrointestinal tract قد لا 
+
+8
+00:00:45,630 --> 00:00:51,380
+يكون بشكل ديارية قد يكون بشكل شلل شلل زي مثلا الـ
+
+9
+00:00:51,380 --> 00:00:54,820
+polio myelitis الكوكساكي فيروس و الـ eco virus
+
+10
+00:00:54,820 --> 00:00:58,980
+درسناهم سابقا بيعملوا meningitis لكن بداية باتهم
+
+11
+00:00:58,980 --> 00:01:03,530
+من وين انتريك فيروس البعض الآخر زي الـ Norwalk و الـ
+
+12
+00:01:03,530 --> 00:01:07,710
+Rotavirus بيناله Diarrhea عند الإنسان طبعا الـ
+
+13
+00:01:07,710 --> 00:01:13,570
+diagram هذا هو ليس فقط لهذا الـ chapter وإنما لكل
+
+14
+00:01:13,570 --> 00:01:18,170
+الـ RNA viruses بيساعدنا في التعرف على الأفراد بناء
+
+15
+00:01:18,170 --> 00:01:22,720
+على بعض الخصائص المميزة مثلًا بنجسم إحنا اللي هم
+
+16
+00:01:22,720 --> 00:01:26,880
+single-stranded RNA و double-stranded RNA، الـ
+
+17
+00:01:26,880 --> 00:01:29,340
+double-stranded RNA فيه فقط واحد اللي هو الريو
+
+18
+00:01:29,340 --> 00:01:32,600
+فايروس، بينما الـ single-stranded هم الآخرين، فيه
+
+19
+00:01:32,600 --> 00:01:36,740
+عندي negative sense و فيه عندي positive sense في
+
+20
+00:01:36,740 --> 00:01:39,840
+عندي segmented و non-segmented في عندي naked و
+
+21
+00:01:39,840 --> 00:01:44,080
+enveloped الـ enveloped أيضا بنجسمه إلى icosahedral
+
+22
+00:01:44,080 --> 00:01:47,860
+و helical يعني بنقدر نعرف من اسم هذا اللي هو مثلا
+
+23
+00:01:47,860 --> 00:01:51,800
+زي إيش هذا coronavirus هو helical enveloped
+
+24
+00:01:51,800 --> 00:01:55,880
+positive sense single-stranded RNA virus يبقى
+
+25
+00:01:55,880 --> 00:02:00,210
+بيساعدنا في التعرف على الفيروس بينما الفيروسات في
+
+26
+00:02:00,210 --> 00:02:03,890
+هذه المحاضرة ستكون إن شاء الله موزعة على تلت أسماء
+
+27
+00:02:03,890 --> 00:02:08,390
+رئيسية اللي هي الـ بيكورنا فيروس و الـ كليسي فيروس و
+
+28
+00:02:08,390 --> 00:02:12,930
+الـ ريو فيروس الريو فيروس بتشمل الروتا فيروس الفيروس
+
+29
+00:02:12,930 --> 00:02:15,830
+الشهير اللي يحدث إسهال عند الأطفال بنسبة كبيرة في
+
+30
+00:02:15,830 --> 00:02:20,150
+العالم و هنا في فلسطين أيضا نحن لسنا باستثناء يعني
+
+31
+00:02:20,150 --> 00:02:24,610
+لدينا هذا الفيروس الكاريسي فيروس حقا ما يعرف عن هذا
+
+32
+00:02:24,610 --> 00:02:27,030
+الفيروس في غزة يعني ما عندنا أي معرفة عن هذا
+
+33
+00:02:27,030 --> 00:02:31,110
+الفيروس في قطاع غزة لكن الـ بيكورنا فيروس والذي
+
+34
+00:02:31,110 --> 00:02:36,150
+اسمه يحتوي على معلومات مهمة بيكو very small RNA
+
+35
+00:02:36,150 --> 00:02:41,050
+small RNA فيروس بيكو RNA فيروس بيكورنا فيروس
+
+36
+00:02:41,050 --> 00:02:45,730
+بتجتمل على الـ انترو فيروس زي الـ بوليو فيروس و
+
+37
+00:02:45,730 --> 00:02:49,210
+الكوكساكي فيروس و الـ ايكو فيروس و الهيباطايتس a
+
+38
+00:02:49,210 --> 00:02:54,240
+فيروس لكن الهيباطايتس انسوها، ليش انسوها؟ لأننا
+
+39
+00:02:54,240 --> 00:02:57,820
+بدنا ناخدها في مجموعة خاصة، ما حنا برضه أول chapter
+
+40
+00:02:57,820 --> 00:03:01,780
+درسناها كان الـ DNA في الـ clinical biology كان الـ
+
+41
+00:03:01,780 --> 00:03:05,100
+DNA virus وكان آخر واحدة منهم اللي هي Hepatitis B
+
+42
+00:03:05,100 --> 00:03:08,040
+وقلنالكوا هذه بدنا ننقلها لـ chapter خاص اسمه
+
+43
+00:03:08,040 --> 00:03:13,870
+Hepatitis viruses بعد الانتروفيروس فيانا الـ راينو
+
+44
+00:03:13,870 --> 00:03:18,750
+فيروس اللي هو الشهير بالرشح المسؤول عن أوراق مواحد
+
+45
+00:03:18,750 --> 00:03:22,350
+مسبب لمرض الرشح اللي إحنا عرفنا أنه فيه أكثر من
+
+46
+00:03:22,350 --> 00:03:27,930
+بلوس بسببه إذن بيكورنا فيروس كاليسي فيروس و ريو
+
+47
+00:03:27,930 --> 00:03:32,420
+فيروس نبدأ إن شاء الله بالـ بيكورنا viruses وهي كما
+
+48
+00:03:32,420 --> 00:03:36,740
+ذكرنا small حوالي عشرين و ثلاثين نانومتر تحتوي على
+
+49
+00:03:36,740 --> 00:03:41,280
+ايكوزاهيدرال نكليوكابسيد single-stranded RNA جينوم
+
+50
+00:03:41,280 --> 00:03:44,200
+بوستف بولارتي وبتالي الجينوم تبقى أحد بيكون يعيش في
+
+51
+00:03:44,200 --> 00:03:49,700
+هذه الحالة infectious أحد ما يتميز به هذا الجينوم
+
+52
+00:03:49,700 --> 00:03:53,900
+مختلف عن باقي الجينوم اللي في الدنيا كلاتها أنه
+
+53
+00:03:53,900 --> 00:04:01,960
+على الـ five prime للـ positive sense RNA يوجد protein مش
+
+54
+00:04:01,960 --> 00:04:05,400
+موجود في الـ others هذا الـ protein serves as a
+
+55
+00:04:05,400 --> 00:04:09,260
+primer يعني بيشتغل كـ primer للـ transcription لهذا
+
+56
+00:04:09,260 --> 00:04:15,440
+الـ gene وبالتالي يعني هو صحيح ببسط في sense RNA
+
+57
+00:04:15,440 --> 00:04:19,340
+لكن محتوى على كده مرة على protein إضافي يساعده على
+
+58
+00:04:19,340 --> 00:04:24,380
+أن يعمل كـ primer للـ transcription الـ بيكورنا فياسبت
+
+59
+00:04:24,380 --> 00:04:28,660
+كثر في الـ cytoplasm دلوقتي على الخلايا وبيشمل اثنين
+
+60
+00:04:28,660 --> 00:04:32,080
+مهمين جدا اللي هم الـ انترو فيروس و الـ رينو فيروس
+
+61
+00:04:32,080 --> 00:04:35,700
+طبعا الـ انترو فيروس جمع يعني ما يبقى حاجة أنه في
+
+62
+00:04:35,700 --> 00:04:41,760
+أنه مجموعة أيضا among the major enterovirus are
+
+63
+00:04:41,760 --> 00:04:48,100
+poliovirus, kokusaki virus, ecovirus and hepatitis
+
+64
+00:04:48,100 --> 00:04:51,820
+A virus و ذكرنا هذا الكلام سابقا اتذكروا يالله
+
+65
+00:04:51,820 --> 00:04:55,380
+يرضى عليكم اثنين و ثلاثة وين ذكرناهم مرة و
+
+66
+00:04:55,380 --> 00:04:58,210
+تكرارا في الاسبتك مينينجايتس في الاسبتك مينينجايتس
+
+67
+00:04:58,210 --> 00:05:01,890
+في الاسبتك مينينجايتس along with mumps they are
+
+68
+00:05:01,890 --> 00:05:05,910
+the most common cause of aseptic meningitis إذا
+
+69
+00:05:05,910 --> 00:05:10,150
+ايكو و الكوكساكي على الرغم من أنهم انتريك فيروس إلا
+
+70
+00:05:10,150 --> 00:05:14,090
+أنهم بيعملوا مينينجايتس تجربة مقارنة سريعة بين
+
+71
+00:05:14,090 --> 00:05:18,750
+الانترو فيروس و بين الـ رينو فيروس أين الانتيرو فيروس
+
+72
+00:05:18,750 --> 00:05:24,770
+ينفكس الـ  أمعاء فقط
+
+73
+00:05:24,770 --> 00:05:29,630
+الناوز و الثروت طبعا أحد ما يعرفلش لأن الـ temperature
+
+74
+00:05:29,630 --> 00:05:32,710
+اللي بينمو عليها الانتيرو فيروس سبعة و ثلاثين
+
+75
+00:05:32,710 --> 00:05:37,550
+بينما الـ رينو فيروس بيهد جداش ثلاثه و ثلاثين في
+
+76
+00:05:37,550 --> 00:05:42,550
+كمان معلومة مهمة جدا اللي هي الـ acidity الانتيرو
+
+77
+00:05:42,550 --> 00:05:46,050
+فيروس هم مقاومين الاسد عشان هم ممروا عبر المعدة و
+
+78
+00:05:46,050 --> 00:05:50,900
+بيصلوا لمين لكن فيروس الرشح لو مر على المعدة لأنه
+
+79
+00:05:50,900 --> 00:05:54,300
+sensitive بتكسر وبالتالي لا يمكن يعمل infection في
+
+80
+00:05:54,300 --> 00:05:59,220
+الأمعاء في practice في رز هنا بعض الناس بتعمله إن
+
+81
+00:05:59,220 --> 00:06:02,500
+المرشح اللي عنده رشح يعني بنبط ليمون في أنفه
+
+82
+00:06:03,500 --> 00:06:07,660
+الليمون أنت تعرفين حامض قد يكون.. قد يكون أحد
+
+83
+00:06:07,660 --> 00:06:10,600
+الأسباب طبعا إحنا.. إحنا.. هذا الـ.. الـ.. الـ
+
+84
+00:06:10,600 --> 00:06:13,380
+common practice was not scientifically tested يعني
+
+85
+00:06:13,380 --> 00:06:16,800
+ما.. لما تم فحصه علميا بس إحنا جايبين بنفسر و
+
+86
+00:06:16,800 --> 00:06:20,240
+بنربط المعلومة بنقول أنه مدان بتأثر بالحامض قد
+
+87
+00:06:20,240 --> 00:06:24,060
+يكون هذا السبب في أن الناس تشعر بتحسن عندما تبع
+
+88
+00:06:24,060 --> 00:06:30,030
+هذا الليمون الآن عدم قدرته على التكاثر إلا في ثلاث
+
+89
+00:06:30,030 --> 00:06:34,250
+ثلاثين وعدم تحمل الـ acid هذا الذي يفسر أن الـ
+
+90
+00:06:34,250 --> 00:06:38,470
+rhinoviruses will not cause gastroenteritis فقط
+
+91
+00:06:38,470 --> 00:06:41,210
+limited to the upper respiratory tract infection
+
+92
+00:06:42,200 --> 00:06:45,560
+الجدول اللي أمامنا هذا ليس جدول للمحاضرة تبعتنا،
+
+93
+00:06:45,560 --> 00:06:50,060
+المفروض أنه جدول عام بيقول ما هي الفيروسات التي
+
+94
+00:06:50,060 --> 00:06:55,380
+تسبب Gastroenteritis، لكن دي جدول مهم لأن كل
+
+95
+00:06:55,380 --> 00:07:00,300
+الفيروسات المذكورة فيه ما عدا واحد من موضوعنا آخر
+
+96
+00:07:00,300 --> 00:07:03,300
+واحد مين هو الـ adenovirus؟ الـ adenovirus كنا من الـ
+
+97
+00:07:03,300 --> 00:07:08,740
+DNA فيروس مظبوط وهو DNA فيروس بالفعل و الباقين كلهم
+
+98
+00:07:08,740 --> 00:07:12,120
+Polio, Eko, Kokusaki, Hepatitis A, Rotavirus,
+
+99
+00:07:12,480 --> 00:07:15,940
+Norovirus كل ما دولة من المجموعة اللي إحنا بدرسها
+
+100
+00:07:15,940 --> 00:07:21,800
+اللي هي الـ RNA، non-enveloped virus حتى الـ
+
+101
+00:07:21,800 --> 00:07:26,840
+adenovirus هو DNA non-enveloped virus اطلعولي على
+
+102
+00:07:26,840 --> 00:07:32,420
+جبل كل شيء على الـ antiviral therapy آخر عمود آخر
+
+103
+00:07:32,420 --> 00:07:36,840
+عمود كلهم ما فيش اللي هم antiviral therapy و أنا
+
+104
+00:07:36,840 --> 00:07:42,280
+قلتلكم من بداية الفصل نحن لسنا ناجحين في إيجاد
+
+105
+00:07:42,280 --> 00:07:45,920
+antivirals زي ما ناجحين في إيجاد antibacterial
+
+106
+00:07:45,920 --> 00:07:52,420
+تمام؟ طبعا اللي بيساعدنا أنهم يعني أنه نواسع نفسنا
+
+107
+00:07:52,420 --> 00:07:55,680
+في هذا المجال أن كثير من الـ viral infection are
+
+108
+00:07:55,680 --> 00:07:59,560
+self-limited لحالة بتروح صحيح ممكن تكون صعبة و
+
+109
+00:07:59,560 --> 00:08:03,400
+ممكن تكون مؤذية لكن في الآخر self-limited معظمها
+
+110
+00:08:03,400 --> 00:08:06,860
+تراها الـ vaccine availability الـ polio طبعا نجم
+
+111
+00:08:06,860 --> 00:08:13,560
+نجوم الـ الـ الأمراض اللي العالم بيسعى إلى التخلص
+
+112
+00:08:13,560 --> 00:08:17,000
+منها تماما وحنشوف كمان شوية إن مرضى مصحى العالمية
+
+113
+00:08:17,000 --> 00:08:20,720
+كانت حاطة هدف من أهدافها الاستراتيجية أنه بحلول
+
+114
+00:08:20,720 --> 00:08:25,600
+عام 2005 عام 2005 مر من 12 سنة تمام؟ أنه بحلول عام
+
+115
+00:08:25,600 --> 00:08:31,040
+2005 أن نتخلص من وباء البوليو فبالتالي الـ vaccine
+
+116
+00:08:31,040 --> 00:08:35,060
+بالفعل موجود وفعال بدرجة كبيرة وخفض نسبة الحالات
+
+117
+00:08:35,060 --> 00:08:39,200
+إلى أعداد ضئيلة جدا سنة كرهة لما نتكلم عن البوليو
+
+118
+00:08:40,680 --> 00:08:44,380
+مين من الفيروسات الآن الثانية له vaccine Hepatitis
+
+119
+00:08:44,380 --> 00:08:49,260
+A virus و بالفعل Hepatitis A أصبح يعني common له
+
+120
+00:08:49,260 --> 00:08:54,000
+التطعيم في كمان فيروس هم ضمن القائمة إحنا حاطينه
+
+121
+00:08:54,000 --> 00:08:55,960
+هنا negative ما فيش له vaccine اللي هو اللي ورا على
+
+122
+00:08:55,960 --> 00:09:01,560
+طول rotavirus الآن فيه rotavirus vaccine يالا نحطه
+
+123
+00:09:01,560 --> 00:09:04,220
+post هنا و أنا هعدله في الـ presentation إن شاء الله
+
+124
+00:09:04,220 --> 00:09:07,830
+أنه موجود له vaccine الآن في سؤال إيه لي أنا بس
+
+125
+00:09:07,830 --> 00:09:12,010
+سؤال أنا حاطه الـ adenovirus أنا حاطه negative و 
+
+126
+00:09:12,010 --> 00:09:15,790
+علامات استفهام، يعني طبعا فيه له vaccine ولا مش 
+
+127
+00:09:15,790 --> 00:09:20,410
+vaccine؟ على علمكم .. على علمكم .. يعني على علمكم
+
+128
+00:09:20,410 --> 00:09:23,410
+واللي دراستكم معه، فيه له vaccine؟ فيه له
+
+129
+00:09:23,410 --> 00:09:27,880
+vaccine ولا مش؟  أيه له vaccine؟ لكن مش للإسهال 
+
+130
+00:09:27,880 --> 00:09:32,360
+للrespiratory احنا جونا فيه عندنا عدد كبير أكثر من
+
+131
+00:09:32,360 --> 00:09:36,380
+أكثر من 41 42 تقريبا strain جونا من اللي هو ال
+
+132
+00:09:36,380 --> 00:09:40,500
+adenoviruses منها مجموعة بتسبب respiratory tract
+
+133
+00:09:40,500 --> 00:09:44,740
+infection وجانا خاصة في الـ military recruit وعملنا
+
+134
+00:09:44,740 --> 00:09:50,290
+لهم فاكسينة تذكروا ثلاث حبات لكن ما عطيناهم مش لأ في
+
+135
+00:09:50,290 --> 00:09:54,010
+الدم، عطيناهم برضه gastro-intestinal بمعنى أنه صار
+
+136
+00:09:54,010 --> 00:09:57,270
+فيه infection في الانتستين mild وحمينا ضد ال
+
+137
+00:09:57,270 --> 00:10:01,230
+respiratory strength لكن ليس لدينا vaccine لحماية
+
+138
+00:10:01,230 --> 00:10:06,070
+الناس من الـ gastroenteritis caused by adenovirus
+
+139
+00:10:06,070 --> 00:10:08,730
+عشان أنا حاطط negative عشان تعرفوا أن negative
+
+140
+00:10:08,730 --> 00:10:11,430
+ما له vaccine ده الـ gastroenteritis لكن ده
+
+141
+00:10:11,430 --> 00:10:14,430
+respiratory tract فيه له vaccine ويعطى فقط
+
+142
+00:10:14,430 --> 00:10:18,770
+لمين؟ للـ militaryبالنسبة للـ Immunity العمودي
+
+143
+00:10:18,770 --> 00:10:22,930
+الثالث من الأخير، من قبل الأخير بيعطينا Hepatitis
+
+144
+00:10:22,930 --> 00:10:26,750
+A والـ Polio lifelong immunity وهذا شيء جيد
+
+145
+00:10:26,750 --> 00:10:31,010
+بالنسبة للـ Serotype الـ Polio بنوعه من الآن أن هو
+
+146
+00:10:31,010 --> 00:10:35,050
+عبارة عن ثلاثة Serotypes وللأسف الثلاثة Serotypes
+
+147
+00:10:35,050 --> 00:10:38,210
+ولا واحد منهم بيعطي cross reactivity مع الثاني
+
+148
+00:10:38,210 --> 00:10:41,950
+بمعنى إنه إذا أصيب الإنسان في واحد ممكن ينصب
+
+149
+00:10:41,950 --> 00:10:44,550
+الثاني ويمكن ينصب الثالث وبالتالي الفاكسينة لازم
+
+150
+00:10:44,550 --> 00:10:49,180
+يحتاج على مين؟ على الثلاثةالـ echovirus ماني،
+
+151
+00:10:49,180 --> 00:10:52,820
+الـ coxsackievirus ماني، ويمكن هذا السبب إن احنا مش
+
+152
+00:10:52,820 --> 00:10:56,600
+قادرين نعمل vaccine، اللهم الـ rotavirus على الرغم
+
+153
+00:10:56,600 --> 00:11:03,140
+من أنه several، إلا أن أهميته خلت العالم يحاول
+
+154
+00:11:03,140 --> 00:11:05,900
+يعمل vaccine وبالفعل نجح، والآن الـ vaccine
+
+155
+00:11:05,900 --> 00:11:11,040
+موجود في السوق ويعطيها للأطفالالـ norovirus unknown
+
+156
+00:11:11,040 --> 00:11:14,900
+يعني هو جديد باكتشافه باعتباره وبالتالي ما عندناش
+
+157
+00:11:14,900 --> 00:11:18,520
+معرفة كبيرة بالنسبة لـ adenovirus احنا ذكرناها سابقا
+
+158
+00:11:18,520 --> 00:11:22,020
+أنه حوالي اثنين وأربعين serotypes لأن تعرف تلعب
+
+159
+00:11:22,020 --> 00:11:27,440
+الأمراض الأولاني الـ poliomyelitis على الرغم إن هي إيش
+
+160
+00:11:27,440 --> 00:11:30,860
+قلناها gastrointestinal infection لكن في الآخر
+
+161
+00:11:30,860 --> 00:11:34,420
+بتروح على الـ nerve وبتعمل poliomyelitis أو شلل
+
+162
+00:11:34,420 --> 00:11:39,710
+الأطفالاثنين وثلاثة بيعملوا meningitis هذا الـ ..
+
+163
+00:11:39,710 --> 00:11:43,530
+الـ .. الـ very .. very common وأكثر important يعني
+
+164
+00:11:43,530 --> 00:11:48,530
+خليني نقول prominent finding of the disease الـ
+
+165
+00:11:48,530 --> 00:11:51,830
+hepatitis أيه؟ Hepatitis وأنا قبل ما أجيكم كان
+
+166
+00:11:51,830 --> 00:11:55,030
+أحد الطلاب يسألني يقول دكتور طب مدام الـ .. الـ
+
+167
+00:11:55,030 --> 00:11:59,610
+hepatitis viruses واحد من الـ DNA virus وواحد من
+
+168
+00:11:59,610 --> 00:12:02,450
+الـ RNA وكل واحد شكل له احنا حاطينه في مجموعة
+
+169
+00:12:02,450 --> 00:12:10,990
+واحد؟ ولماذا هناك فيروسات بتصيب الكبد ولم تحسب مع
+
+170
+00:12:10,990 --> 00:12:15,830
+الهيباتيتس فيروس؟ يبقى في عندنا سؤالين ليش هم
+
+171
+00:12:15,830 --> 00:12:19,250
+مختلفين وحطيناهم في مجموعة واحدة وليه آخرين
+
+172
+00:12:19,250 --> 00:12:22,430
+بيعملوا الهيباتيتس ومحطيناهم مش مع هذه المجموعة
+
+173
+00:12:22,430 --> 00:12:29,250
+تعالوا نعرف الهيباتيتس فيروس their main and only
+
+174
+00:12:29,250 --> 00:12:34,980
+target is the liverيعني ما فيش عندهم أماكن أخرى
+
+175
+00:12:34,980 --> 00:12:39,520
+يعملوها infection فقط في وين؟ في الـ liver هدول
+
+176
+00:12:39,520 --> 00:12:43,300
+اللي Hepatitis Viruses طب مش ضمنهم مع بعض، في
+
+177
+00:12:43,300 --> 00:12:46,320
+مشكلة عندنا حقيقية لما بيكون واحد عنده Hepatitis
+
+178
+00:12:46,320 --> 00:12:50,680
+بقى بنتفرج نعرف إنها A ولا B ولا C ولا D إلا من
+
+179
+00:12:50,680 --> 00:12:55,740
+خلال فحوصات يبقى بتشابه تشابه كبير طيب معرفتنا
+
+180
+00:12:55,740 --> 00:12:59,660
+بنوع الـ virus هل مهم بالنسبة لنا؟ أكيد مهم، عرفيه
+
+181
+00:12:59,660 --> 00:13:04,900
+ليه مهم؟ مش بس موضوع علاج، لأ موضوع وقاية، موضوع
+
+182
+00:13:04,900 --> 00:13:11,080
+monitoring، لأن مثلًا A وE هدول جروح لحالهم،
+
+183
+00:13:11,080 --> 00:13:15,600
+بينما B وC ممكن يتحول لـ chronic infection وممكن
+
+184
+00:13:15,600 --> 00:13:18,720
+الـ chronic infection هدول يكونوا carrier ويكونوا
+
+185
+00:13:18,720 --> 00:13:23,260
+infectious للآخرين وممكن البعض منهم يتحول إلى liver
+
+186
+00:13:23,260 --> 00:13:27,800
+cancer liver cancer إذا معرفتنا بنوع الـ virus مهم
+
+187
+00:13:27,800 --> 00:13:31,160
+جدا ليه الـ other viruses اللي بتصيب الـ liver
+
+188
+00:13:31,160 --> 00:13:36,080
+ما حطناش مع هذه المجموعة إذا كانت بتصيب أعضاء أخرى
+
+189
+00:13:36,080 --> 00:13:41,400
+ما بنحطهاش مع الـ hepatitis virus إذا خصصنا الـ
+
+190
+00:13:41,400 --> 00:13:46,140
+hepatitis viruses إلى تلك التي فقط تصيب مين اللي
+
+191
+00:13:46,140 --> 00:13:51,190
+هو تلكبالنسبة للـ pathogens كلهم كانوا عملوا دياري الـ
+
+192
+00:13:51,190 --> 00:13:53,630
+rotavirus والـ norwalk والـ adenovirus كانوا
+
+193
+00:13:53,630 --> 00:13:57,930
+مسببين للدياري بالنسبة للـ nucleic acid كلهم RNA معدي
+
+194
+00:13:57,930 --> 00:14:03,170
+الـ adenovirus إذا الشيء المشترك بينهم أنهم non
+
+195
+00:14:03,170 --> 00:14:08,050
+enveloped viruses صح؟ non enveloped virus لكن لحظة
+
+196
+00:14:08,050 --> 00:14:12,030
+كلهم تابعين كمان مرة أو معروفين تابعين لمين؟ للـ RNA
+
+197
+00:14:12,030 --> 00:14:14,970
+مش للـ DNA واحد فقط من الـ DNA virus
+
+198
+00:14:17,600 --> 00:14:22,440
+طب نيجي للـ enterovirus وبالأخير الـ poliovirus
+
+199
+00:14:26,850 --> 00:14:30,950
+الـ disease اللي بتسببه هذا الفيروس اسمه poliomyelitis
+
+200
+00:14:30,950 --> 00:14:35,870
+أو بالعربية شلل الأطفال أو الشلل الشلل important
+
+201
+00:14:35,870 --> 00:14:40,150
+properties الفيروس بيصيب الـ primates الـ primates
+
+202
+00:14:40,150 --> 00:14:42,770
+اللي هم الأوليات اللي هي الأرقى الثديات اللي بيقول
+
+203
+00:14:42,770 --> 00:14:48,050
+عنها الإنسان والقرود الـ apes اللي هي الغوريلا والقرود
+
+204
+00:14:48,050 --> 00:14:52,100
+الأخرىطبعًا هذا بيصيبهم مش بِعد الحاجة إن هم
+
+205
+00:14:52,100 --> 00:14:54,280
+الـ natural host، الـ natural host هو فقط من
+
+206
+00:14:54,280 --> 00:14:58,060
+الإنسان، لكن الـ virus قد يصيب .. يعني لو احنا
+
+207
+00:14:58,060 --> 00:15:02,790
+experimentally ممكن نصيب في هذه المخلوقاتالـ RNA
+
+208
+00:15:02,790 --> 00:15:05,490
+تابعه لأنه هناك وإنه بوصت في سنسه هو infectious
+
+209
+00:15:05,490 --> 00:15:08,490
+فيه three physiological types وهذا الكلام عرفناه من
+
+210
+00:15:08,490 --> 00:15:14,030
+الجدول based on different antigenic components على
+
+211
+00:15:14,030 --> 00:15:16,690
+الكبسيد تبعه اللي ما عامفش ياخدوا بالكم هو envelope
+
+212
+00:15:16,690 --> 00:15:20,250
+ما فيش envelope فأي antigenic تبعها تكون على
+
+213
+00:15:20,250 --> 00:15:23,410
+الكبسيد لما بيكون في envelope لما بيكون في 
+
+214
+00:15:23,410 --> 00:15:26,390
+envelope بيتكلم عن الـ envelope لما ما يكونش في
+
+215
+00:15:26,390 --> 00:15:31,670
+envelope بيتكلم عن مين؟ عن الكبسيد itself زي ما
+
+216
+00:15:31,670 --> 00:15:34,670
+حكينا ما فيش cross-reaction بين الـ strains وبالتالي
+
+217
+00:15:34,670 --> 00:15:38,330
+الإنسان اللي بيصاب بواحد بيوفرش حماية للآخرين أو
+
+218
+00:15:38,330 --> 00:15:41,250
+الاثنين الآخرين بينتقل عبر الـ fecal oral route
+
+219
+00:15:41,250 --> 00:15:46,170
+ودعوني أذكر هنا بنقطة أو بقضية مهمة في موضوع الـ
+
+220
+00:15:46,170 --> 00:15:49,520
+transmission اللي هو الـ fecal oral routeطب هذا ما
+
+221
+00:15:49,520 --> 00:15:54,640
+بنعزو انخفاض نسب الإصابة مثلًا في عملاء الفيروسية
+
+222
+00:15:54,640 --> 00:15:58,080
+زي للـ vaccine، مظهر؟ بنقول أن الـ vaccine حسن من ..
+
+223
+00:15:58,080 --> 00:16:01,740
+هذا كلام صحيح، لكن اللي بيحسن أكثر من الـ vaccine
+
+224
+00:16:01,740 --> 00:16:06,380
+هو الـ improvement في الـ .. والـ proper sewage
+
+225
+00:16:06,380 --> 00:16:11,380
+disposal، تخلص الأمن منين؟ من المياه العادمة،
+
+226
+00:16:11,380 --> 00:16:15,650
+المياه العادمةوبيعطيكم بس بعض الـ .. يعني اللمحات
+
+227
+00:16:15,650 --> 00:16:20,530
+عن تاريخيًا في غزة النهاردة، قبل عشرين سنة كنا نعمل
+
+228
+00:16:20,530 --> 00:16:23,510
+testing لعينات الـ stool من بعض المناطق، بتنشأتكم
+
+229
+00:16:23,510 --> 00:16:28,340
+المناطق، بيزعلوا أصحابهافكنا نجد فيها نسب الإصابة
+
+230
+00:16:28,340 --> 00:16:32,520
+بالبراغيث مثل طريقة مثال مثل الـ Ascaris مثل الـ Guardia
+
+231
+00:16:32,520 --> 00:16:35,280
+والـ Amoeba والـ Mixed Infection نكون نلاقي ثلاثة
+
+232
+00:16:35,280 --> 00:16:39,240
+أو اثنين مع بعض في نفس العينة كانت نسب كبيرة في
+
+233
+00:16:39,240 --> 00:16:42,680
+بعض المناطق لما جينا التلّانة على المناطق هذه لجينا
+
+234
+00:16:42,680 --> 00:16:46,240
+أن الفرق بينها وبين المناطق الأخرى أن ما فيش فيها
+
+235
+00:16:46,240 --> 00:16:49,640
+sewage system ما فيش فيها أنظمة ضخمة جارية كانت
+
+236
+00:16:49,640 --> 00:16:53,380
+بتنده عالمين على الحفر اللي بيحفروها ويتخلصوا من
+
+237
+00:16:53,380 --> 00:16:56,520
+النفايات المنزلية وكل ما يتعبى يتصلوا في البلدية
+
+238
+00:16:56,520 --> 00:17:00,400
+تيجي تتخلصهم من هذا الـ .. طبعًا الشوارع كانت غير
+
+239
+00:17:00,400 --> 00:17:03,980
+مرصوفة أيضًا فكانت نسبة النفايات والمياه العادمة ما
+
+240
+00:17:03,980 --> 00:17:08,220
+تصل للشوارع ففي هذه الحالة عملية الانتقال كانت
+
+241
+00:17:08,220 --> 00:17:13,370
+سهلة جدًا فيها الـ oral transmissionلأن لما نفس
+
+242
+00:17:13,370 --> 00:17:16,910
+المنطقة صار فيها sewage system والشوارع تباتها
+
+243
+00:17:16,910 --> 00:17:22,490
+رُصفت أصبحت هذه المنطقة أقل إصابة من مناطق أخرى
+
+244
+00:17:22,490 --> 00:17:26,590
+كانت في السابق تُعرف عليها يعني من أرقى المناطق
+
+245
+00:17:26,590 --> 00:17:30,300
+وأنظف المناطقيبقى الفارق اللي .. اللي حصل ما ..
+
+246
+00:17:30,300 --> 00:17:32,440
+ما عملنا vaccine جديد للبراغيث، ما فيش vaccine
+
+247
+00:17:32,440 --> 00:17:36,460
+للبراغيث، تمام؟ كل اللي صار أنه بس حسنّا الـ
+
+248
+00:17:36,460 --> 00:17:40,200
+storage disposal وغطينا الشوارع، غطينا الشوارع من
+
+249
+00:17:40,200 --> 00:17:43,540
+الـ .. من الـ .. من الأطفال، ما بيبولوش، بيبرزوش في
+
+250
+00:17:43,540 --> 00:17:46,960
+هذه المناطق وبالتالي ما فيش transmission، والمياه 
+
+251
+00:17:46,960 --> 00:17:51,570
+العادية ما بطلت تصل هذه الشوارع إذا الفيكل oral
+
+252
+00:17:51,570 --> 00:17:56,170
+transmission حلّه الرئيسي هو proper sewage
+
+253
+00:17:56,170 --> 00:18:01,670
+treatment أو disposal and treatment و public
+
+254
+00:18:01,670 --> 00:18:05,770
+health يعني خلّيني نقول measures sanitation نظافة
+
+255
+00:18:05,770 --> 00:18:10,290
+عامة و نظافة شخصية هدول التلات حلول حتى في غياب
+
+256
+00:18:10,290 --> 00:18:13,250
+اللقاحات قد تساعدوا في خفض اللي هو الإصابة
+
+257
+00:18:13,250 --> 00:18:16,430
+بالأمراض المنتقلة عن طريق الـ oral route والذي
+
+258
+00:18:16,430 --> 00:18:18,330
+يعتبر الـ polio أحدها
+
+259
+00:18:27,840 --> 00:18:31,100
+النظافة العامة متمثلة في الأشياء اللي ذكرناها
+
+260
+00:18:31,100 --> 00:18:35,400
+بتساعد كتير it can replicate in the oropharynx and
+
+261
+00:18:35,400 --> 00:18:37,960
+intestinal tract human are the only natural host
+
+262
+00:18:37,960 --> 00:18:42,900
+successful vaccines have eradicated the disease
+
+263
+00:18:42,900 --> 00:18:47,550
+from the united states and indeed from the entire
+
+264
+00:18:47,550 --> 00:18:52,310
+western hemisphere نصف الكرة الأرضية الغربي تم
+
+265
+00:18:52,310 --> 00:18:57,710
+تحلص من هذا الفيروس الحياة النادية التي حدثت في
+
+266
+00:18:57,710 --> 00:19:03,730
+الولايات المتحدة حدثت من أمثلة كالتالي: واحد وناس
+
+267
+00:19:03,730 --> 00:19:08,490
+تعرضوا لـ الـ virus revertant of the attenuated
+
+268
+00:19:08,490 --> 00:19:13,630
+virus كلكوا تذكروا الأيوب أو مش الأيوب المخاوف
+
+269
+00:19:13,630 --> 00:19:18,910
+التي تحدثنا عنها من الـ live attenuated اللي هو الـ
+
+270
+00:19:18,910 --> 00:19:24,010
+live vaccine أحد هذه المخاوف أنه يتحول من
+
+271
+00:19:24,010 --> 00:19:27,570
+attenuated إلى الـ wild type أو الـ active type
+
+272
+00:19:27,570 --> 00:19:30,950
+حالات حدثت في الولايات المتحدة من تعرض ناس لـ
+
+273
+00:19:30,950 --> 00:19:37,010
+revertant رقم اثنين وناس مش مطعمين ذهبوا إلى
+
+274
+00:19:37,010 --> 00:19:40,630
+أماكن موبوءة و اتعرضوا لـ الـ wild type الـ wild type
+
+275
+00:19:40,630 --> 00:19:44,870
+هو الـ بيروس مش المضعف الـ wild يعني بري اللي هو
+
+276
+00:19:44,870 --> 00:19:48,130
+الحقيقي الـ .. الـ .. الـ attenuated هو اللي استقبلنا
+
+277
+00:19:48,130 --> 00:19:52,960
+في مين؟ في الـ vaccine فهو مش مطعم طفل مثلاً ولد في
+
+278
+00:19:52,960 --> 00:19:56,600
+الولايات المتحدة ما تطعمش وسافر أهله على منطقة
+
+279
+00:19:56,600 --> 00:19:59,640
+موبوءة مثل باكستان أو أفغانستان لأنه لأن هم
+
+280
+00:19:59,640 --> 00:20:03,040
+الدولتان الوحيدتان اللي عملوا تقرير السنة الماضية
+
+281
+00:20:03,040 --> 00:20:07,400
+أنه ما زال فيهم polio myelitis ففي هذه الحالة ممكن
+
+282
+00:20:07,400 --> 00:20:11,920
+ينتقل إليهم اللي هو الفيروس ما .. قبل ما بيستخدم
+
+283
+00:20:11,920 --> 00:20:18,540
+الـ vaccine كانت الأوبئة تحدث في الصيف وفي الخريف
+
+284
+00:20:18,540 --> 00:20:23,650
+الـ fall معناها خريف مكتوب فيها خريف كما ذكرت لكم
+
+285
+00:20:23,650 --> 00:20:26,870
+المنظمة الصحية العالمية حاولت أنها تحط هدف أن في
+
+286
+00:20:26,870 --> 00:20:31,710
+الـ 2005 بحيث عام 2005 أنها تنهي من اللي هو الـ
+
+287
+00:20:31,710 --> 00:20:36,910
+polio myelitis لكن للأسف في 2007 كان هناك 16 دولة
+
+288
+00:20:36,910 --> 00:20:42,350
+ما زال فيها polio إلا أن نسبة الإصابات انخفضت يعني
+
+289
+00:20:42,350 --> 00:20:45,630
+الجهود اللي بذلت ما راحتها بقى صحيح ما زال فيه
+
+290
+00:20:45,630 --> 00:20:50,130
+polio لكن الناس بقى اتطلعوا في العام 1988 وهذا الـ
+
+291
+00:20:50,130 --> 00:20:53,900
+vaccine كان موجود يعني كان فيه حوالي أكثر من ربع
+
+292
+00:20:53,900 --> 00:20:58,520
+مليون حالة سنوية worldwide طيب في العام 2005
+
+293
+00:20:58,520 --> 00:21:02,220
+كان العدد أقل من جدًّا من 2000 في العام 2000
+
+294
+00:21:02,220 --> 00:21:05,040
+و16 اللي هو العام المنصرم كان العدد أقل من
+
+295
+00:21:05,040 --> 00:21:07,760
+100 أظن 68 أو 66 لا أذكر الرقم
+
+296
+00:21:07,760 --> 00:21:12,180
+لكن أقل بالتأكيد أقل من 100 حالة ومن دولتين فقط
+
+297
+00:21:12,180 --> 00:21:16,380
+هنا جدًّا كانوا 16 دولة الآن صاروا كده 2 دولتين
+
+298
+00:21:16,620 --> 00:21:20,120
+ومتوقع في الأعوام القادمة إذا بقي الـ rhythm على ما
+
+299
+00:21:20,120 --> 00:21:25,580
+هو في نشاطنا في التطعيم والتوعية والمراقبة أن
+
+300
+00:21:25,580 --> 00:21:31,660
+بالفعل أنه بحلول عام 2020 أن نكون خلصنا من الـ polio
+
+301
+00:21:31,660 --> 00:21:36,920
+إذا لم نستطع نتخلص من الـ polio، نتخلص من مين احنا
+
+302
+00:21:36,920 --> 00:21:38,860
+فقط؟ من الـ small box
+
+303
+00:21:41,280 --> 00:21:44,720
+بعد ما بتتكاثر الفيروسات في الـ .. الـ .. الـ .. الـ 
+
+304
+00:21:44,720 --> 00:21:44,860
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+305
+00:21:44,860 --> 00:21:45,560
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ال
+
+306
+00:21:45,560 --> 00:21:45,860
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+307
+00:21:45,860 --> 00:21:48,540
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ال
+
+308
+00:21:48,540 --> 00:21:53,280
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ال
+
+309
+00:21:53,280 --> 00:21:58,820
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+310
+00:21:58,820 --> 00:21:59,380
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+311
+00:21:59,380 --> 00:22:02,560
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+312
+00:22:10,520 --> 00:22:13,360
+بسمّوه innervating يعني بي بي بي بي بي بي بي بي بي
+
+313
+00:22:13,360 --> 00:22:13,500
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+314
+00:22:13,500 --> 00:22:13,620
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+315
+00:22:13,620 --> 00:22:19,560
+بي بي بي بي بي بي بي بي بي بي بي بي
+
+316
+00:22:19,560 --> 00:22:23,080
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+317
+00:22:23,080 --> 00:22:26,200
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+318
+00:22:26,200 --> 00:22:29,260
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+319
+00:22:29,260 --> 00:22:36,540
+بي ب
+
+320
+00:22:39,480 --> 00:22:45,260
+من القرن الماضي كانت شائعة أن نشوف أطفال من جيلنا
+
+321
+00:22:45,260 --> 00:22:50,100
+أو أكبر منّا تمامًا أنهم يكونوا عندهم شلل أو بيعانوا
+
+322
+00:22:50,100 --> 00:22:56,650
+من شلل في أحد الأطراف من ناتج عن أنا حتى لما بعرف
+
+323
+00:22:56,650 --> 00:23:00,030
+بعض الأشخاص يعني من السن تبقى يعني أكبر شويّة
+
+324
+00:23:00,030 --> 00:23:05,690
+مصابين بهذا المرض الخبيث والذي يعني أنا كتبت عنه
+
+325
+00:23:05,690 --> 00:23:08,990
+مقالة من ضمن المقالات اللي كنت أكتبها في سلسلة
+
+326
+00:23:08,990 --> 00:23:12,350
+اسمها ميكروبات صنعت لها مكانًا في التاريخ فهذا
+
+327
+00:23:12,350 --> 00:23:16,450
+الميكروب من الميكروبات اللي كان يثير القشعريرة في
+
+328
+00:23:16,450 --> 00:23:20,710
+.. عندما يسمع الإنسان باسمه لأنه على الرغم من أنه
+
+329
+00:23:21,350 --> 00:23:26,210
+نسبة إحداثه لشلل الأطفال في الناس المصابين قليلة
+
+330
+00:23:26,210 --> 00:23:31,450
+جدًّا إلا أنها بالنسبة لأنه debilitating شلل مش حاجة
+
+331
+00:23:31,450 --> 00:23:37,770
+يعني فقد مثلاً سماع في أذن أو كده لأ الآن هو مشلول
+
+332
+00:23:37,770 --> 00:23:42,710
+هذا يعني complicated خطيرة على الإنسان رقم اثنين
+
+333
+00:23:42,710 --> 00:23:48,000
+فيه كمان نسبة وفيات لابأس بها لأنه بيدمّر الـ brain
+
+334
+00:23:48,000 --> 00:23:53,420
+stem والـ brain stem مسؤولة عن بعض الحركات
+
+335
+00:23:53,420 --> 00:23:59,540
+اللاإرادية زي التنفس فإذا ضربت الـ brain stem بيضرب
+
+336
+00:23:59,540 --> 00:24:03,740
+التنفس وبالتالي بيموت المريض من respiratory failure
+
+337
+00:24:05,760 --> 00:24:09,760
+الـ Paralysis بينتج عن هذا المرض اللي ممكن نادى
+
+338
+00:24:09,760 --> 00:24:11,800
+الجملة الأخيرة، death of these cells result in
+
+339
+00:24:11,800 --> 00:24:14,820
+paralysis of the muscle innervated by those
+
+340
+00:24:14,820 --> 00:24:17,540
+neurons وبالتالي بيصير لنا شرع اللي جونا عنه
+
+341
+00:24:17,540 --> 00:24:23,470
+الارتخاء الـ Plasma Stem زي ما حكينا بيدّي لغير الـ
+
+342
+00:24:23,470 --> 00:24:26,610
+Poliomyelitis بالإضافة لـ Respiratory Paralysis
+
+343
+00:24:26,610 --> 00:24:29,930
+اللي هو الشلل في عضلات اللي هو الجهاز التنفسي
+
+344
+00:24:29,930 --> 00:24:34,470
+المناعة والاستجابة المناعية لهذا الـ .. الـ بيروس
+
+345
+00:24:34,470 --> 00:24:39,670
+غالباً تتشكّل من شغلتين أساسيتين اللي هم Intestinal
+
+346
+00:24:39,670 --> 00:24:43,710
+IgA وهذا مهم جداً لـ Intestinal IgA بالإضافة إلى
+
+347
+00:24:43,710 --> 00:24:50,810
+Humoral اللي هو الـ IgG هذه المناعة تعطي lifelong
+
+348
+00:24:50,810 --> 00:24:54,530
+immunity وهي specific مناعة لهستيريني اللي بسبب
+
+349
+00:24:54,530 --> 00:25:00,230
+المرض الآن تعالوا نطلع المرض ايه أشكاله في الإنسان
+
+350
+00:25:00,230 --> 00:25:06,110
+هو polyomyelitis لكن طلعوا مقسم إلى أربعة أصناف
+
+351
+00:25:07,210 --> 00:25:10,830
+99% من الصنف الأول ايش هو
+
+352
+00:25:10,830 --> 00:25:13,670
+inapparent يعني 99% من الناس اللي
+
+353
+00:25:13,670 --> 00:25:17,810
+بينصبّوا الـ polio لا يظهر عليهم أي أعراض الـ 1%
+
+354
+00:25:17,810 --> 00:25:21,730
+موزعة على مين؟ على abortive وكلمة abortive
+
+355
+00:25:21,730 --> 00:25:26,910
+تعني mild form of the disease ايش mild form؟ شكل
+
+356
+00:25:26,910 --> 00:25:32,660
+بسيط من المرض الرقم تلاتة الـ Non-paralytic في عراب
+
+357
+00:25:32,660 --> 00:25:37,180
+وخاصة حملة وفيه ألم لكن الـ Non-paralytic لا
+
+358
+00:25:37,180 --> 00:25:42,560
+تؤدي إلى شلل الرابعة وهي الأقل اللي هي Paralytic
+
+359
+00:25:42,560 --> 00:25:46,620
+Poliomyelitis إذا Inapparent, abortive, Non
+
+360
+00:25:46,620 --> 00:25:50,740
+-paralytic and Paralytic Poliomyelitis مين الـ most
+
+361
+00:25:50,740 --> 00:25:55,800
+common؟ الأولى Asymptomatic infection is quite
+
+362
+00:25:55,800 --> 00:25:59,700
+common. Roughly only one percent of infections are
+
+363
+00:25:59,700 --> 00:26:03,860
+clinically apparent يبقى الـ clinically apparent هم
+
+364
+00:26:03,860 --> 00:26:08,240
+التلاتة الباقيين يبقى كل الـ الـ الـ 1%
+
+365
+00:26:08,240 --> 00:26:11,560
+بشكل التلاتة لسه فيه ياندي اللي هم الـ abortive اللي
+
+366
+00:26:11,560 --> 00:26:14,800
+هي الـ mild form والـ non paralytic والأخيرة اللي
+
+367
+00:26:14,800 --> 00:26:18,940
+هي الـ paralytic poliomyelitis الـ incubation period
+
+368
+00:26:18,940 --> 00:26:23,860
+من 10 إلى 14 يوم الـ most common form هو
+
+369
+00:26:23,860 --> 00:26:27,760
+الـ abortive poliomyelitis which is a mild febrile
+
+370
+00:26:27,760 --> 00:26:31,100
+كلمة febrile يعني فيه سخونة في حرارة illness
+
+371
+00:26:31,100 --> 00:26:34,680
+characterized by headache, sore throat, nausea and
+
+372
+00:26:34,680 --> 00:26:41,500
+vomiting معظم المرضى بيشوفوا تلقائيًا بدون حتى تدخل
+
+373
+00:26:41,500 --> 00:26:46,740
+لـ supportive treatment ولا غيره بيشوفوا تلقائيًا الـ
+
+374
+00:26:46,740 --> 00:26:51,540
+Non-paralytic poliomyelitis manifests as aseptic
+
+375
+00:26:51,540 --> 00:26:55,220
+meningitis، إذا بدكم تلاحظوا الآن إنه صار عندنا
+
+376
+00:26:55,220 --> 00:27:00,200
+أربعة meningitis اللي أنتم درستوهم، هذكركم كمان مرة 
+
+377
+00:27:00,200 --> 00:27:06,480
+الأساسيات ماما، إيكوفيروس، كوكساكي فيروس ويعني هنا
+
+378
+00:27:06,480 --> 00:27:10,220
+اللي هو الـ poliomyelitis virus
+
+379
+00:27:13,090 --> 00:27:15,910
+الستيفنك اللي طلع على الستيفنك أنتم عارفين هي أصلاً
+
+380
+00:27:15,910 --> 00:27:20,210
+واحدة من أنواع الـ meningitis الستيفنك اللي هي رقبة
+
+381
+00:27:20,210 --> 00:27:25,230
+المتصلبة، رقبة المتصلبة برضه this infection resolve
+
+382
+00:27:25,230 --> 00:27:29,750
+spontaneously المشكلة اللي هنتكلم عنها الآن في الرابع
+
+383
+00:27:29,750 --> 00:27:33,690
+اللي هي الـ paralytic poliomyelitis which causes
+
+384
+00:27:33,690 --> 00:27:38,600
+flaccid paralysis is the prominent finding كمان ال
+
+385
+00:27:38,600 --> 00:27:42,360
+brain stem involvement كان ممكن يؤدي إلى جنة اللي
+
+386
+00:27:42,360 --> 00:27:47,540
+هو الفشل في عملية التنفس وهذا مهدد لحياة الإنسان
+
+387
+00:27:47,540 --> 00:27:51,980
+في الزمن اللي كان البوليو منتشر، اضطروا يخترعوا
+
+388
+00:27:51,980 --> 00:27:55,780
+كبسولات حديد يعني يحطوا فيها المريض عشان يشغلوا 
+
+389
+00:27:55,780 --> 00:28:01,740
+فيها ضغط يعني جهاز كهربائي يضغط صدر المريض فيخرج
+
+390
+00:28:01,740 --> 00:28:07,160
+الهواء ثم يعني يفرج الضغط فيضطر المريض ياخد الهواء
+
+391
+00:28:07,160 --> 00:28:10,520
+يعني وكانوا تنفس صناعي، تنفس صناعي اليوم الأجهزة
+
+392
+00:28:10,520 --> 00:28:14,740
+التنفس الصناعي أصبحت يعني في متناول اليد مش زي
+
+393
+00:28:14,740 --> 00:28:19,570
+التعقيدات السابقة يعني صارت أفضل من ذي قبل، طبعاً هذا
+
+394
+00:28:19,570 --> 00:28:24,350
+الجهاز كان يبقى المريض فيه ممكن سنة سنتين وفي
+
+395
+00:28:24,350 --> 00:28:29,810
+غالب الأمر يموت، فكانوا يعني محاولة
+
+396
+00:28:29,810 --> 00:28:34,030
+من قبل الأطباء أو الأهل أنهم يعني يبقوا مريضهم
+
+397
+00:28:34,030 --> 00:28:38,710
+طبعاً وهناك أيضاً معاناة شديدة لأنه في انقباضات
+
+398
+00:28:38,710 --> 00:28:42,570
+asbestic painful asbestic
+
+399
+00:28:45,160 --> 00:28:47,800
+painful muscle spasm زي ما حكينا هنا painful
+
+400
+00:28:47,800 --> 00:28:52,100
+muscle spasm also occur وزي ما حكينا لكم الـ motor
+
+401
+00:28:52,100 --> 00:28:56,180
+nerve damage بيكون permanent في أصلاً عندنا nerve
+
+402
+00:28:56,180 --> 00:28:59,900
+damage مش permanent كل الـ nerve damage بيكون
+
+403
+00:28:59,900 --> 00:29:04,100
+permanent لكن بيقول لنا أنه بعد ما بيشفى المريض إذا
+
+404
+00:29:04,100 --> 00:29:08,380
+شفاء المريض وصار عنده شلل في الأول بيكون
+
+405
+00:29:08,380 --> 00:29:14,320
+الحركة ضعيفة خالص لكن بيصير في بعض التحسن في الحركة
+
+406
+00:29:14,320 --> 00:29:19,260
+لأنه يبدو إن الخلايا السليمة اللي موجودة بتاخذ دور
+
+407
+00:29:19,260 --> 00:29:23,900
+الخلايا لكن لا يعود اللي هو المريض كما كان من
+
+408
+00:29:23,900 --> 00:29:29,340
+دقيقة قبل، في مصطلحين لازم نعرفهم للتعبير عن المدى
+
+409
+00:29:29,340 --> 00:29:33,100
+الأعضاء اللي صارت involved في الالتهاب مثلاً لما
+
+410
+00:29:33,100 --> 00:29:36,700
+بنقول meninges بنقول meningitis ولا لأ؟ لكن لو كان
+
+411
+00:29:36,700 --> 00:29:41,440
+meninges و brain برانكما بنقول meningoencephalitis
+
+412
+00:29:41,440 --> 00:29:43,780
+لما يكون التنين مع بعض involved يعني صار فيهم
+
+413
+00:29:43,780 --> 00:29:48,060
+inflammation meningoencephalitis إذا الـ spinal
+
+414
+00:29:48,060 --> 00:29:50,960
+cord كمان مصاب، إيش بنقول؟
+
+415
+00:29:50,960 --> 00:29:54,520
+meningomyeloencephalitis، ولا حاجة، ما فيش يعني
+
+416
+00:29:54,520 --> 00:29:59,200
+نضيف مقاطع، بس meningomyeloencephalitis،
+
+417
+00:29:59,200 --> 00:30:04,930
+is often used كمصطلح الـ lab diagnosis لهذا الفيروس
+
+418
+00:30:04,930 --> 00:30:10,010
+يتم عبر عزل الفيروس أو من خلال ارتفاع في تركيز الـ
+
+419
+00:30:10,010 --> 00:30:14,110
+antibody-titer اللي بنعرفه دائماً الفيروس ممكن يعزل
+
+420
+00:30:14,110 --> 00:30:18,150
+من الـ throat من الستول ومن الـ spinal fluid من
+
+421
+00:30:18,150 --> 00:30:23,800
+خلال زرع هذه العينات إلى cell cultures الفيروس
+
+422
+00:30:23,800 --> 00:30:29,400
+بيسبب الـcytopathic effect وممكن نتعرف على الفيروس
+
+423
+00:30:29,400 --> 00:30:33,700
+من خلال الـneutralization للـcytopathic effect
+
+424
+00:30:33,700 --> 00:30:37,720
+with specific antibodies يعني عندي antibody ثلاثة
+
+425
+00:30:37,720 --> 00:30:41,580
+للواحد والاتنين والثلاثة اللي هم ثلاثة strains الآن
+
+426
+00:30:41,580 --> 00:30:44,320
+الفيروس أنا نميته عامل الـcytopathic effect هذا
+
+427
+00:30:44,320 --> 00:30:47,030
+الـcytopathic effect يمكن يكون لأي فيروس أكيد
+
+428
+00:30:47,030 --> 00:30:51,250
+بدي أعرف إنه للـ poliovirus بروح بحط عليه أول حاجة
+
+429
+00:30:51,250 --> 00:30:57,030
+الثلاثة antibodies إذا الثلاثة antibodies منعوا ال
+
+430
+00:30:57,030 --> 00:31:01,770
+virus يبقى هو poliovirus إذا بدي أعرف أنه سلالة
+
+431
+00:31:01,770 --> 00:31:05,440
+منهم بأفحصه على ثلاثة cell cultures وبحط على ال
+
+432
+00:31:05,440 --> 00:31:09,020
+cell culture الأولى Antibody X Antibody Y Antibody
+
+433
+00:31:09,020 --> 00:31:13,640
+Z وبشوف وين مانع عشان أعرف بالضبط إيش نوع السلالة
+
+434
+00:31:13,640 --> 00:31:16,820
+يبقى بنجي نتعرف على الـ virus من خلال الـ inhibition
+
+435
+00:31:16,820 --> 00:31:23,160
+للـ cytopathic effect with specific antibodies طبعاً
+
+436
+00:31:23,160 --> 00:31:26,080
+specific antisera نفس المعنى أه، antisera أو
+
+437
+00:31:26,080 --> 00:31:28,460
+antibody نفس المعنى treatment there is no
+
+438
+00:31:28,460 --> 00:31:32,020
+antiviral therapy treatment is limited to
+
+439
+00:31:32,020 --> 00:31:35,580
+symptomatic relief and respiratory support زي ما
+
+440
+00:31:35,580 --> 00:31:39,420
+حكينا اللي هي الفشل اللي هو الجهاز التنفسي if
+
+441
+00:31:39,420 --> 00:31:44,200
+needed فيزيو ثيرابي اللي هو العلاج الطبيعي for the
+
+442
+00:31:44,200 --> 00:31:47,300
+affected muscles is important بعد الشفاء بيتم
+
+443
+00:31:47,300 --> 00:31:51,120
+عملية اللي هو rehabilitation اللي هي إعادة تأهيل
+
+444
+00:31:51,120 --> 00:31:57,280
+للأطفال بيحسنه كده مرة بيرجعش normal لكن بيحسنه من
+
+445
+00:31:57,280 --> 00:31:59,680
+الأداء الحركي لهذه العضلة
+
+446
+00:32:02,580 --> 00:32:07,200
+الـ prevention بالأساس زي ما ذكرت لكم أنا اعتمد على ال
+
+447
+00:32:07,200 --> 00:32:10,000
+vaccine لكن ذكرت لكم ملاحظة على ملاحظة اللي هي ال
+
+448
+00:32:10,000 --> 00:32:14,340
+sewage disposal هذه عامة جداً هناك نوعين من ال
+
+449
+00:32:14,340 --> 00:32:18,120
+vaccine واحد اسمه Salk واحد اسمه Sabine وهذول
+
+450
+00:32:18,120 --> 00:32:21,720
+Sabine و Salk علماء هم اللي طوروا، فلو نقول Salk
+
+451
+00:32:21,720 --> 00:32:25,320
+vaccine و Sabine vaccine هذول أعتقد.. أعتقد..
+
+452
+00:32:25,320 --> 00:32:27,640
+والله لأ أنا مش فاكر.. مش متأكد إنهم أخذوا جائزة
+
+453
+00:32:27,640 --> 00:32:31,580
+نوبل برضه في الطب الاكتشاف هم هذول الـ.. إيه؟
+
+454
+00:32:31,580 --> 00:32:36,020
+اللي هم الـ.. الـ.. الـ vaccines لإنه كمرة الـ virus
+
+455
+00:32:36,020 --> 00:32:40,100
+خطير قاتل له consequences سيئة له ال
+
+456
+00:32:40,100 --> 00:32:44,880
+polymyelitis وبتالي أن نلاقي حد يعطينا حل له هذا
+
+457
+00:32:44,880 --> 00:32:51,460
+شيء مميز، IPV-OPV هو Intramuscular .. عفواً..
+
+458
+00:32:51,460 --> 00:32:56,320
+Inactivated Polio Vaccine و Oral Vaccine اللي هو
+
+459
+00:32:56,320 --> 00:33:06,020
+OPV، إذا IPV و OPV، اتذكروا Killed Salk سالك قتل
+
+460
+00:33:06,020 --> 00:33:15,680
+سالِك و سابين قتل
+
+461
+00:33:15,680 --> 00:33:21,860
+سالِك
+
+462
+00:33:22,720 --> 00:33:28,300
+both vaccine induces humoral antibodies شوفت إن ال
+
+463
+00:33:28,300 --> 00:33:33,300
+immunity لهذا الفيروس مرتبط بشكل كبير بالـ IGA و
+
+464
+00:33:33,300 --> 00:33:38,240
+IGG يعني ما قلناش كتير عن مين؟ عن الـ cell mediated
+
+465
+00:33:38,240 --> 00:33:44,700
+immunity أكدنا على الـ IGA و IGG why؟ which
+
+466
+00:33:44,700 --> 00:33:48,240
+neutralizes virus entering the blood and hence
+
+467
+00:33:48,240 --> 00:33:51,580
+prevents central nervous system infection أنا أصلاً
+
+468
+00:33:51,580 --> 00:33:56,040
+خايف على أن الفيروس يصل وين يصل؟ اللي هو الـ central
+
+469
+00:33:56,040 --> 00:33:59,440
+nervous system فإذا اتكون antibody جوا الدم و
+
+470
+00:33:59,440 --> 00:34:02,680
+الفيروس جزء من انتقال الـ central nervous system
+
+471
+00:34:02,680 --> 00:34:05,560
+لازم يمر عبر مين؟ عبر الدم فهذا بيعمل ال
+
+472
+00:34:05,560 --> 00:34:09,240
+neutralization فالدور الكبير لهذا الفيروس معتمد
+
+473
+00:34:09,240 --> 00:34:12,870
+على الـ immunolever both the killed and live
+
+474
+00:34:12,870 --> 00:34:16,330
+vaccines contain all three zero types يعني هذا
+
+475
+00:34:16,330 --> 00:34:22,630
+سواء كان killed أو live وبالمناسبة ما ذكرناش عن
+
+476
+00:34:22,630 --> 00:34:31,130
+الـ advantage و disadvantage للاثنين موجودين طيب لأن
+
+477
+00:34:31,130 --> 00:34:36,050
+بدنا نعمل مقارنة بين بين سالك killed أو بين سبين
+
+478
+00:34:36,050 --> 00:34:39,590
+اللي هو live prevent disease كليهما نعم بيعمل
+
+479
+00:34:39,590 --> 00:34:43,430
+prevention للـ disease interrupt transmission لحظة
+
+480
+00:34:43,430 --> 00:34:48,110
+الـ killed لأ بينما الـ live نعم بيعمل interruption
+
+481
+00:34:48,110 --> 00:34:52,550
+للـ transmission بينتقلش من الإنسان إلى إنسان يعني
+
+482
+00:34:52,550 --> 00:34:57,290
+بحميني أنا تمام والفيروس ما هو أنا قلت لكم مرة مش
+
+483
+00:34:57,290 --> 00:35:01,170
+مش في الـ intestinal tract بيصير تكاثر وبيصير له
+
+484
+00:35:01,170 --> 00:35:08,040
+excretion تمام ليش ما عملش interruption؟ لأنه أصلاً
+
+485
+00:35:08,040 --> 00:35:14,340
+ما قدش induction لـ IGA أما هذا عمل فقط لمين؟ لـ IG
+
+486
+00:35:14,340 --> 00:35:20,880
+.. هذا بتلاحظوا Induced Humoral IGG كلمة نعم بينما
+
+487
+00:35:20,880 --> 00:35:25,980
+الـ IGA فقط مين؟ الـ live vaccine afford secondary
+
+488
+00:35:25,980 --> 00:35:29,080
+protection by spread to others؟ No Yes بحاجة كده
+
+489
+00:35:29,080 --> 00:35:32,860
+برضه بنفس المعنى الـ transmission interfere with the
+
+490
+00:35:32,860 --> 00:35:35,100
+replication of virulent strains in the gut؟ No
+
+491
+00:35:35,100 --> 00:35:40,920
+لأنه ما عندهوش كمان مرة IGA Yes إذا الآن كل هذه
+
+492
+00:35:40,920 --> 00:35:44,700
+المزايا في صالح مين؟ قلناها؟ في صالح الـ life الآن
+
+493
+00:35:44,700 --> 00:35:48,280
+revert to virulence أكيد لأنه أنا ميت بينما هذا
+
+494
+00:35:48,280 --> 00:35:53,640
+yes لكن بنجو سين راري طبعاً كلمة rarely هي إشارة
+
+495
+00:35:53,640 --> 00:35:57,480
+إلى الاحتمالية يعني إحنا لنا سنوات نتكلم عن ال
+
+496
+00:35:57,480 --> 00:36:04,130
+vaccine مناسب أو مناسبتين حدث وبالتالي كلمة rarely
+
+497
+00:36:04,130 --> 00:36:08,470
+هي فقط إشارة للناس إن دلوقتي يا مصنعين، دلوقتي يا
+
+498
+00:36:08,470 --> 00:36:12,310
+مطعمين، بتكونوا تراقبوا أنتم كمان الـ vaccines
+
+499
+00:36:12,310 --> 00:36:17,110
+اللي بتصنعوها واللي بتاعتها بتكونوا تراقبوا هذا ال
+
+500
+00:36:17,110 --> 00:36:17,730
+vaccine
+
+501
+00:36:21,580 --> 00:36:24,440
+with other enterovirus may impair immunization،
+
+502
+00:36:24,440 --> 00:36:30,120
+إيش معنى impair؟ impair يعني بيخرّب، تمام؟ هل لو
+
+503
+00:36:30,120 --> 00:36:33,540
+صار co-infection مع ال vaccine، أنا أخدت ال
+
+504
+00:36:33,540 --> 00:36:36,680
+vaccine و صار عندي انترك فيروس infection، هل بيعوق
+
+505
+00:36:36,680 --> 00:36:42,120
+أو بيفشل ال vaccination، بقولنا في الكل لأ بيعوّقش،
+
+506
+00:36:42,120 --> 00:36:46,480
+ليش؟ أنا ماخده انترا مسكلةبينما الـ enteric virus
+
+507
+00:36:46,480 --> 00:36:50,700
+أو ال oral اللي هو ال live أخدناها oral وبالتالي
+
+508
+00:36:50,700 --> 00:36:55,320
+بالفعل ممكن يعملوا interference مع بعض Can cause
+
+509
+00:36:55,320 --> 00:36:58,940
+disease in the immune compromise؟ No بالنسبة
+
+510
+00:36:58,940 --> 00:37:04,580
+لـ killed بينما yes بالنسبة لـ live إذا ال juice اللي
+
+511
+00:37:04,580 --> 00:37:08,220
+هلوي واضح أنه اللي صالح مين الـ live و الـ juice
+
+512
+00:37:08,220 --> 00:37:09,860
+الشفلي صالح مين الـ kill
+
+513
+00:37:12,980 --> 00:37:16,600
+Route of administration injection and oral التاني
+
+514
+00:37:16,600 --> 00:37:19,960
+oral اورال لأن احنا بدنا يتكاثر جوا الأمهات ويعمل
+
+515
+00:37:19,960 --> 00:37:27,280
+induction لـ ال IGA production Route
+
+516
+00:37:27,280 --> 00:37:30,020
+of administration oral خلصنا منها requires
+
+517
+00:37:30,020 --> 00:37:34,220
+refrigeration نو الـ killed بينما الـ live's a being
+
+518
+00:37:34,220 --> 00:37:39,650
+yesفاكرين الجثة اللى حكتكوا عن ال cold transport
+
+519
+00:37:39,650 --> 00:37:42,930
+chain فى ال vaccine ودالكوا ان ال vaccine لازم من
+
+520
+00:37:42,930 --> 00:37:46,950
+المصنع اللى طلع منه لحد ما يصل لمخازن تبعتنا لازم
+
+521
+00:37:46,950 --> 00:37:52,330
+يكون معاه شهادة بتقول انه مر بدرجة حرارة 22 و 21 و
+
+522
+00:37:52,330 --> 00:37:57,130
+نص 22 و نص يعني تاريخ مروره اسمها cold transport
+
+523
+00:37:57,130 --> 00:38:02,050
+chain فبالتالي في بعض ال vaccine من ميزاتها ان انا
+
+524
+00:38:02,050 --> 00:38:04,670
+بحطها على الراف عارفين اني بحطها على الراف ميزات؟
+
+525
+00:38:04,670 --> 00:38:09,090
+لأن التلاجة طاقة طب في غزة انها انا ايش من انا في
+
+526
+00:38:09,090 --> 00:38:12,090
+التلاجة اللي بتفصل؟ بدنا نشغلها المواطين؟ يعني
+
+527
+00:38:12,090 --> 00:38:17,450
+الابقاءها في ظرف ملائم لها في التخزين هذا أمر حيوي
+
+528
+00:38:17,450 --> 00:38:22,010
+وبالتالي هو أمر مكلف هو حيوي نعم وضروري لكن مكلف
+
+529
+00:38:23,570 --> 00:38:27,090
+Duration of immunity في الـ killed بتكون shorter و
+
+530
+00:38:27,090 --> 00:38:31,490
+بالـ live بتكون longer لإنه هي عبارة عن بناء
+
+531
+00:38:31,490 --> 00:38:37,890
+simulation لـ natural infection يعني زي محاكاة لمرض
+
+532
+00:38:37,890 --> 00:38:41,190
+حقيقي احنا خدنا ال oral و صار فيه اندي infection و
+
+533
+00:38:41,190 --> 00:38:45,390
+يمكن وصل الدم كمان تمام لكن الفيروس ضعيف وبالتالي
+
+534
+00:38:45,390 --> 00:38:52,000
+تم التخلص منه تماماً هذا الفيروس الأول في السلسلة
+
+535
+00:38:52,000 --> 00:38:57,280
+ننتقل الآن لفيروس تاني اسمه كوكساكي virus كوكساكي
+
+536
+00:38:57,280 --> 00:39:01,220
+virus are named for .. named for يعني سمية على اسم
+
+537
+00:39:01,220 --> 00:39:04,220
+اللي هو الـ town of كوكساكي موجودة في نيو يورك
+
+538
+00:39:04,220 --> 00:39:08,700
+where they were first isolated يعني تم عزلها في
+
+539
+00:39:08,700 --> 00:39:12,760
+مدينة كوكساكي في منطقة نيو يورك وبالتالي سمية على
+
+540
+00:39:12,760 --> 00:39:19,940
+اسمها الكوكساكي virus بسبب مجموعة من الأمراضبينجسم
+
+541
+00:39:19,940 --> 00:39:25,620
+على group A و group Bالـ .. ال .. ال .. ال .. ال
+
+542
+00:39:25,620 --> 00:39:26,340
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+543
+00:39:26,340 --> 00:39:26,660
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+544
+00:39:26,660 --> 00:39:26,740
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+545
+00:39:26,740 --> 00:39:34,400
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+546
+00:39:34,400 --> 00:39:37,140
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+547
+00:39:37,140 --> 00:39:37,200
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+548
+00:39:37,200 --> 00:39:37,220
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+549
+00:39:37,220 --> 00:39:38,100
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+550
+00:39:38,100 --> 00:39:40,400
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+551
+00:39:40,400 --> 00:39:46,300
+.. ال .. ال .. ال .. ال .. ال
+
+552
+00:39:49,480 --> 00:39:55,500
+في كمان مرض للغاية سيّء اسمه hand, foot and mouth
+
+553
+00:39:55,500 --> 00:40:01,400
+disease بيطلع blisters بيطلع بيطلع بيطلع بيطلع
+
+554
+00:40:01,400 --> 00:40:02,660
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+555
+00:40:02,660 --> 00:40:02,720
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+556
+00:40:02,720 --> 00:40:18,600
+بيطلع بيطلع بيطل
+
+557
+00:40:18,640 --> 00:40:21,540
+طبعا هداك اللي .. اللي مولود في الأبقار حصل أنه
+
+558
+00:40:21,540 --> 00:40:24,220
+السنة الماضية أو اللي جابلها وحصل أنه قبل أدت
+
+559
+00:40:24,220 --> 00:40:28,980
+سنوات ونسبة القتل فيه للحيوانات بتكون عالية جدا،
+
+560
+00:40:28,980 --> 00:40:31,840
+يعني فيروس من الفيروسات اللي بيسميها الاقتصادية
+
+561
+00:40:31,840 --> 00:40:36,480
+بتأثر على اقتصاد الـ .. البلد وخاصة أنه نتكلم عن
+
+562
+00:40:36,480 --> 00:40:42,940
+قطعان ماشية مكلفة أثمنجروب بي فيروس بتسبب حاجة
+
+563
+00:40:42,940 --> 00:40:49,200
+اسمها pleurodyna وينهدى عبارة عن pain عضلات بين
+
+564
+00:40:49,200 --> 00:40:55,500
+الأضلاع او في الديافرام الحجاب الحاجز myocarditis
+
+565
+00:40:55,500 --> 00:41:01,180
+و pericarditis اذا الكوكساكي فيروس غالبا بيسبب
+
+566
+00:41:01,180 --> 00:41:04,520
+مجموعتين من الأمرض بيسموها group a و group b
+
+567
+00:41:04,520 --> 00:41:06,700
+infection
+
+568
+00:41:09,810 --> 00:41:14,310
+Types cause nonspecific upper respiratory tract
+
+569
+00:41:14,310 --> 00:41:18,250
+disease, common cold, febrile rashes and aseptic
+
+570
+00:41:18,250 --> 00:41:18,790
+meningitis
+
+571
+00:41:39,830 --> 00:41:41,630
+نكمل باقي المجموعات
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2f398d2ccf454ae26691076a3f5f3c55cf2d028a
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0_postprocess.srt
@@ -0,0 +1,2284 @@
+1
+00:00:20,990 --> 00:00:23,930
+فبسم الله الرحمن الرحيم اليوم موضوع جديد ان شاء
+
+2
+00:00:23,930 --> 00:00:28,550
+الله متعلق بال RNA non-enveloped viruses وهي
+
+3
+00:00:28,550 --> 00:00:33,010
+مجموعة أقل من التي سبقتها لكن بنركز فيها على
+
+4
+00:00:33,010 --> 00:00:36,650
+مجموعة غالبا ما تصيب ال gastrointestinal tract
+
+5
+00:00:36,650 --> 00:00:39,770
+البعض منها طبعا بصيب أماكن أخرى زي ال rhino virus
+
+6
+00:00:39,770 --> 00:00:43,170
+لكن المعظم بيأثر على ال gastrointestinal tract
+
+7
+00:00:43,170 --> 00:00:45,630
+الآن التأثير على ال gastrointestinal tract قد لا
+
+8
+00:00:45,630 --> 00:00:51,380
+يكونبشكل ديارية قد يكون بشكل شلل شلل زي مثلا ال
+
+9
+00:00:51,380 --> 00:00:54,820
+polio myelitis الكوكساكي فيروس و ال eco virus
+
+10
+00:00:54,820 --> 00:00:58,980
+درسناهم سابقا بيعملوا meningitis لكن بداية باتهم
+
+11
+00:00:58,980 --> 00:01:03,530
+من وين انتريك فيروس البعض الآخرزي ال Norwalk و ال
+
+12
+00:01:03,530 --> 00:01:07,710
+Rotavirus بيناله Diarrhea عند الإنسان طبعا ال
+
+13
+00:01:07,710 --> 00:01:13,570
+diagram هذا هو ليس فقط لهذا ال chapter و انما لكل
+
+14
+00:01:13,570 --> 00:01:18,170
+ال RNA viruses بيساعدنا في التعرف على الأفراد بناء
+
+15
+00:01:18,170 --> 00:01:22,720
+على بعض الخصائص المميزة مثلابنجسم احنا اللي هم
+
+16
+00:01:22,720 --> 00:01:26,880
+single-stranded RNA و double-stranded RNA، الـ
+
+17
+00:01:26,880 --> 00:01:29,340
+double-stranded RNA فيه فقط واحد اللي هو الريو
+
+18
+00:01:29,340 --> 00:01:32,600
+فايروس، بينما ال single-stranded هم الآخرين، فيه
+
+19
+00:01:32,600 --> 00:01:36,740
+عندي negative sense و فيه عندي positive senseفي
+
+20
+00:01:36,740 --> 00:01:39,840
+عندي segmented و non-segmented في عندي naked و
+
+21
+00:01:39,840 --> 00:01:44,080
+enveloped ال enveloped أيضا بنجسمه إلى icosahedral
+
+22
+00:01:44,080 --> 00:01:47,860
+و helical يعني بنقدر نعرف من اسم هذا اللي هو مثلا
+
+23
+00:01:47,860 --> 00:01:51,800
+زي ايش هذا coronavirus هو helical enveloped
+
+24
+00:01:51,800 --> 00:01:55,880
+positive sense single-stranded RNA virus يبقى
+
+25
+00:01:55,880 --> 00:02:00,210
+بيساعدنا في التعرف على الفيروسبينما الفيروسات في
+
+26
+00:02:00,210 --> 00:02:03,890
+هذه المحاضرة ستكون ان شاء الله موزعة على تلت أسماء
+
+27
+00:02:03,890 --> 00:02:08,390
+رئيسية اللي هي ال بيكورنا فيروس و الكليسي فيروس و
+
+28
+00:02:08,390 --> 00:02:12,930
+الريو فيروس الريو فيروس بتشمل الروتا فيروس الفيروس
+
+29
+00:02:12,930 --> 00:02:15,830
+الشهير اللي يحدث أسهال عند الأطفال بنسبة كبيرة في
+
+30
+00:02:15,830 --> 00:02:20,150
+العالم و هنا في فلسطين ايضا نحن لسنا باستثناء يعني
+
+31
+00:02:20,150 --> 00:02:24,610
+لدينا هذا الفيروسالكاريسي فيروس حقا مايعرف عن هذا
+
+32
+00:02:24,610 --> 00:02:27,030
+الفيروس في غزة يعني ماعنداش اي معرفة عن هذا
+
+33
+00:02:27,030 --> 00:02:31,110
+الفيروس في قطاع غزة لكن ال بيكورنا فيروس والذي
+
+34
+00:02:31,110 --> 00:02:36,150
+اسمها يحتوي على معلومات مهمة بيكو very small RNA
+
+35
+00:02:36,150 --> 00:02:41,050
+small RNA فيروس بيكو RNA فيروس بيكورنا فيروس
+
+36
+00:02:41,050 --> 00:02:45,730
+بتجتمل على ال انترو فيروس زي ال بوليو فيروس و
+
+37
+00:02:45,730 --> 00:02:49,210
+الكوكساكي فيروس و الايكو فيروس و الهيباطايتس a
+
+38
+00:02:49,210 --> 00:02:54,240
+فيروس لكن الهيباطايتسانسوها، ليش انسوها؟ لأننا
+
+39
+00:02:54,240 --> 00:02:57,820
+بدنا ناخدها في مجموعة خاصة، ماحنا برضه أول chapter
+
+40
+00:02:57,820 --> 00:03:01,780
+درسناها كان ال DNA في ال clinical biology كان ال
+
+41
+00:03:01,780 --> 00:03:05,100
+DNA virus وكان أخر واحدة منهم اللي هي Hepatitis B
+
+42
+00:03:05,100 --> 00:03:08,040
+وقلنالكوا هذه بدنا ننقلها ل chapter خاص اسمه
+
+43
+00:03:08,040 --> 00:03:13,870
+Hepatitis virusesبعد الانتروفيروس فيانا الراينو
+
+44
+00:03:13,870 --> 00:03:18,750
+فيروس اللي هو الشهير بالرشح المسئول عن أوراق مواحد
+
+45
+00:03:18,750 --> 00:03:22,350
+مسبب لمرض الرشح اللي احنا عرفنا انه فيه أكتر من
+
+46
+00:03:22,350 --> 00:03:27,930
+بلوس بسببه إذن ب كورنا فيروس كاليسي فيروس وريو
+
+47
+00:03:27,930 --> 00:03:32,420
+فيروسنبدأ ان شاء الله بال بيكورنا viruses وهي كما
+
+48
+00:03:32,420 --> 00:03:36,740
+ذكرنا small حوالي عشرين و تلاتين نانومتر تحتوي على
+
+49
+00:03:36,740 --> 00:03:41,280
+ايكوزاهيدرال نكليوكابسيد single-stranded RNA جينوم
+
+50
+00:03:41,280 --> 00:03:44,200
+بوستف بولارتي وبتالي الجينم تبقى احد بيكون يعيش في
+
+51
+00:03:44,200 --> 00:03:49,700
+هذه الحالة infectious احد ما يتميز به هذا الجينوم
+
+52
+00:03:49,700 --> 00:03:53,900
+مختلف عن باقي الجينوم اللي في الدنيا كلاتها انه
+
+53
+00:03:53,900 --> 00:04:01,960
+على ال five prime لل بوستف سينس RNAيوجد protein مش
+
+54
+00:04:01,960 --> 00:04:05,400
+موجود في ال others هذا ال protein serves as a
+
+55
+00:04:05,400 --> 00:04:09,260
+primer يعني بيشتغل كprimer لل transcription لهذا
+
+56
+00:04:09,260 --> 00:04:15,440
+ال gene وبالتالي يعني هو صحيح ببسط في sense RNA
+
+57
+00:04:15,440 --> 00:04:19,340
+لكن محتوى على كده مرة على protein إضافي يساعده على
+
+58
+00:04:19,340 --> 00:04:24,380
+ان يعمل كprimer لل transcription ال بيكورنا فياسبت
+
+59
+00:04:24,380 --> 00:04:28,660
+كثر في الcytoplasm دلوقتي على الخلاياو بيشمل اتنين
+
+60
+00:04:28,660 --> 00:04:32,080
+مهمين جدا اللي هم ال انترو فيروس و ال رينو فيروس
+
+61
+00:04:32,080 --> 00:04:35,700
+طبعا ال انترو فيروس جمع يعني ما يبقى حاجة انه في
+
+62
+00:04:35,700 --> 00:04:41,760
+انه مجموعة ايضا among the major enterovirus are
+
+63
+00:04:41,760 --> 00:04:48,100
+poliovirus, kokusaki virus, ecovirus and hepatitis
+
+64
+00:04:48,100 --> 00:04:51,820
+A virus و ذكرنا هذا الكلام سابقا اتذكروا يالله
+
+65
+00:04:51,820 --> 00:04:55,380
+يرضى عليكم اتنين و تلاتة وين ذكرناهم مرانا و
+
+66
+00:04:55,380 --> 00:04:58,210
+تكرارافي الاسبتك مينينجايتس في الاسبتك مينينجايتس
+
+67
+00:04:58,210 --> 00:05:01,890
+في الاسبتك مينينجايتس along with mumps they are
+
+68
+00:05:01,890 --> 00:05:05,910
+the most common cause of aseptic meningitis اذا
+
+69
+00:05:05,910 --> 00:05:10,150
+ايكو والكوكساكي على الرغم من انهم انتريك فيروس الا
+
+70
+00:05:10,150 --> 00:05:14,090
+انهم بيعملوا مينينجايتس تجربة مقارنة سريعة بين
+
+71
+00:05:14,090 --> 00:05:18,750
+الانترو فيروس وبين ال رينو فيروسأين الانتيرو فيروس
+
+72
+00:05:18,750 --> 00:05:24,770
+انفكس الوامين فقط
+
+73
+00:05:24,770 --> 00:05:29,630
+الناوز والثروت طبعا حد مايعرفلش لان ال temperature
+
+74
+00:05:29,630 --> 00:05:32,710
+اللي بينمو عليها الانتيرو فيروس سبعة و تلاتين
+
+75
+00:05:32,710 --> 00:05:37,550
+بينما ال رينو فيروس بيهد جداش تلاتة و تلاتين في
+
+76
+00:05:37,550 --> 00:05:42,550
+كمان معلومة مهمة جدا اللي هي ال acidity الانتيرو
+
+77
+00:05:42,550 --> 00:05:46,050
+فيروس هم مقاومين الاسد عشان هم ممروا عبر المعدة و
+
+78
+00:05:46,050 --> 00:05:50,900
+بيصلوا لمينلكن فيروس الرشح لو مر على المعدة لانه
+
+79
+00:05:50,900 --> 00:05:54,300
+sensitive بتكسر وبالتالي لايمكن يعمل infection في
+
+80
+00:05:54,300 --> 00:05:59,220
+الأمعاء في practice في رز هنا بعض الناس بتعمله ان
+
+81
+00:05:59,220 --> 00:06:02,500
+المرشح اللي عنده رشح يعنيه بنبط لمون في أنفه
+
+82
+00:06:03,500 --> 00:06:07,660
+الليمون انت تعرفين حامض قد يكون .. قد يكون احد
+
+83
+00:06:07,660 --> 00:06:10,600
+الأسباب طبعا احنا .. احنا .. هذا ال .. ال .. ال
+
+84
+00:06:10,600 --> 00:06:13,380
+common practice was not scientifically tested يعني
+
+85
+00:06:13,380 --> 00:06:16,800
+ما .. لما تم فحصه علميا بس احنا جايبين بنفسر و
+
+86
+00:06:16,800 --> 00:06:20,240
+بنربط المعلومة بنقول انه مدان بتأثر بالحامض قد
+
+87
+00:06:20,240 --> 00:06:24,060
+يكون هذا السبب في انه الناس تشعر بتحسن عندما تبع
+
+88
+00:06:24,060 --> 00:06:30,030
+هذا الليمونالان عدم قدرته على التكاثر الا في تلات
+
+89
+00:06:30,030 --> 00:06:34,250
+تلاتين وعدم تحمل ال acid هذا الذي يفسر ان ال
+
+90
+00:06:34,250 --> 00:06:38,470
+rhinoviruses will not cause gastroenteritis فقط
+
+91
+00:06:38,470 --> 00:06:41,210
+limited to the upper respiratory tract infection
+
+92
+00:06:42,200 --> 00:06:45,560
+الجدول اللي أمامنا هذا ليس جدول للمحاضرة تبعتنا،
+
+93
+00:06:45,560 --> 00:06:50,060
+المفروض أنه جدول عام بيقول ما هي الفيروسات التي
+
+94
+00:06:50,060 --> 00:06:55,380
+تسبب Gastroenteritis، لكن دي جدول مهم لأن كل
+
+95
+00:06:55,380 --> 00:07:00,300
+الفيروسات المذكورة فيه ما عدا واحد من موضوعناأخر
+
+96
+00:07:00,300 --> 00:07:03,300
+واحد مين هو ال adenovirus؟ ال adenovirus كنا من ال
+
+97
+00:07:03,300 --> 00:07:08,740
+DNA فيروس مظبوط وهو DNA فيروس بالفعل والباقين كلهم
+
+98
+00:07:08,740 --> 00:07:12,120
+Polio, Eko, Kokusaki, Hepatitis A, Rotavirus,
+
+99
+00:07:12,480 --> 00:07:15,940
+Norovirus كل ما دولة من المجموعة اللي احنا بدرسها
+
+100
+00:07:15,940 --> 00:07:21,800
+اللي هي ال RNA، non-enveloped virusحتى ال
+
+101
+00:07:21,800 --> 00:07:26,840
+adenovirus هو DNA non-enveloped virus اطلعولي على
+
+102
+00:07:26,840 --> 00:07:32,420
+جبل كل إشي على ال antiviral therapy أخر عمود أخر
+
+103
+00:07:32,420 --> 00:07:36,840
+عمود كلهم مافيش اللي هم antiviral therapy و أنا
+
+104
+00:07:36,840 --> 00:07:42,280
+قلتلكم من بداية الفصل نحن لسنا ناجحين في إيجاد
+
+105
+00:07:42,280 --> 00:07:45,920
+antivirals زي ما ناجحين في إيجاد antibacterial
+
+106
+00:07:45,920 --> 00:07:52,420
+تمام؟طبعا اللي بيساعدنا انهم يعني انه نواسع نفسنا
+
+107
+00:07:52,420 --> 00:07:55,680
+في هذا المجال انه كثير من ال viral infection are
+
+108
+00:07:55,680 --> 00:07:59,560
+self-limited لحالة بتروح صحيح ممكن تكون صعبة و
+
+109
+00:07:59,560 --> 00:08:03,400
+ممكن تكون مؤذية لكن في الآخر self-limited معظمها
+
+110
+00:08:03,400 --> 00:08:06,860
+تراها ال vaccine availability ال poly طبعا نجم
+
+111
+00:08:06,860 --> 00:08:13,560
+نجوم ال ال الالأمراض اللي العالم بيسعى إلى التخلص
+
+112
+00:08:13,560 --> 00:08:17,000
+منها تماما وحنشوف كمان شوية ان مرضى مصحى العالمية
+
+113
+00:08:17,000 --> 00:08:20,720
+كانت حاطة هدف من أهدافها ال استراتيجية انه بحلول
+
+114
+00:08:20,720 --> 00:08:25,600
+عام 2005 عام 2005 مر من 12 سنة تمام؟ انه بحلول عام
+
+115
+00:08:25,600 --> 00:08:31,040
+2005 ان نتخلص من وباء البوليو فبالتالي ال vaccine
+
+116
+00:08:31,040 --> 00:08:35,060
+بالفعل موجود وفعال بدرجة كبيرة وخفض نسبة الحالات
+
+117
+00:08:35,060 --> 00:08:39,200
+إلى أعداد ضئيلة جدا سنة كرهة لما نتكلم عن البوليو
+
+118
+00:08:40,680 --> 00:08:44,380
+مين من الفيروسات الآن التانية له vaccine Hepatitis
+
+119
+00:08:44,380 --> 00:08:49,260
+A virus وبالفعل Hepatitis A أصبح يعني common له
+
+120
+00:08:49,260 --> 00:08:54,000
+التطعيم في كمان فيروس هم ضمن القائمة احنا حاطينه
+
+121
+00:08:54,000 --> 00:08:55,960
+هنا negative مافيش له vaccine اللي هو اللي ورا على
+
+122
+00:08:55,960 --> 00:09:01,560
+طول rotavirus الان فيه rotavirus vaccine يالا نحطه
+
+123
+00:09:01,560 --> 00:09:04,220
+post هنا وانا هعدله في ال presentation ان شاء الله
+
+124
+00:09:04,220 --> 00:09:07,830
+انه موجود له vaccineالان في سؤال ايه لي أنا بس
+
+125
+00:09:07,830 --> 00:09:12,010
+سؤال انا حاطه ال adenovirus انا حاطه negative و
+
+126
+00:09:12,010 --> 00:09:15,790
+علامات استفهام، يعني طبعا فيه له vaccine ولا مش
+
+127
+00:09:15,790 --> 00:09:20,410
+vaccine؟ على علمكم .. على علمكم .. يعني على عملتكم
+
+128
+00:09:20,410 --> 00:09:23,410
+و اللي دراستكم معاه، فيه له vaccine؟ فيه له
+
+129
+00:09:23,410 --> 00:09:27,880
+vaccine ولا مش؟ ايه له vaccine؟لكن مش للإسهال
+
+130
+00:09:27,880 --> 00:09:32,360
+للrespiratory احنا جونا فيه عنا عدد كبير اكتر من
+
+131
+00:09:32,360 --> 00:09:36,380
+اكتر من 41 42 تقريبا strain جونا من اللي هو ال
+
+132
+00:09:36,380 --> 00:09:40,500
+adenoviruses منها مجموعة بتسبب respiratory tract
+
+133
+00:09:40,500 --> 00:09:44,740
+infection وجونا خاصة في ال military recruit وعملنا
+
+134
+00:09:44,740 --> 00:09:50,290
+لهم فاكسينة تذكروا تلت حباتلكن ماعطيناهم مش لأ في
+
+135
+00:09:50,290 --> 00:09:54,010
+الدم، عطيناهم برضه gastro-intestinal بمعنى انه صار
+
+136
+00:09:54,010 --> 00:09:57,270
+فيه infection في الانتستين mild و حماتنا ضد ال
+
+137
+00:09:57,270 --> 00:10:01,230
+respiratory strength لكن ليس لدينا vaccine لحماية
+
+138
+00:10:01,230 --> 00:10:06,070
+الناس من ال gastroenteritis caused by adenovirus
+
+139
+00:10:06,070 --> 00:10:08,730
+عشان انا حاطيت negative عشان تعرفوا ان negative
+
+140
+00:10:08,730 --> 00:10:11,430
+مالوش vaccine ده ال gastroenteritis لكن ده
+
+141
+00:10:11,430 --> 00:10:14,430
+respiratory tracked فيه له vaccine و يعطى فقط
+
+142
+00:10:14,430 --> 00:10:18,770
+لمين؟ للمilitaryبالنسبة للـ Immunity العمودي
+
+143
+00:10:18,770 --> 00:10:22,930
+الثالث من الأخير، من قبل الأخير بيعطينا Hepatitis
+
+144
+00:10:22,930 --> 00:10:26,750
+A و الـ Polio lifelong immunity وهذا شيء جيد
+
+145
+00:10:26,750 --> 00:10:31,010
+بالنسبة للـ Serotype الـ Polio بنوعه من الآن أن هو
+
+146
+00:10:31,010 --> 00:10:35,050
+عبارة عن ثلاثة Serotypes وللأسف الثلاثة Serotypes
+
+147
+00:10:35,050 --> 00:10:38,210
+ولا واحد منهم بيعطي cross reactivity مع التاني
+
+148
+00:10:38,210 --> 00:10:41,950
+بمعنى إنه إذا وصيك الإنسان في واحد ممكن ينصب
+
+149
+00:10:41,950 --> 00:10:44,550
+التاني ويمكن ينصب التالت وبالتالي الفاكسينة لازم
+
+150
+00:10:44,550 --> 00:10:49,180
+يحتاج على مين؟ على الثلاثةالإيكوفيروس ماني،
+
+151
+00:10:49,180 --> 00:10:52,820
+الكوكساكي فيروس ماني، ويمكن هذا السبب إن احنا مش
+
+152
+00:10:52,820 --> 00:10:56,600
+قادرين نعمل vaccine، اللهم الروتافيروس على الرغم
+
+153
+00:10:56,600 --> 00:11:03,140
+من أنه several، إلا أنه أهميته خلت العالم يحاول
+
+154
+00:11:03,140 --> 00:11:05,900
+يعمل vaccine و بالفعل نجحه، و الآن ال vaccine
+
+155
+00:11:05,900 --> 00:11:11,040
+موجود في السوق ويعطيها للأطفالالنوروفيروس unknown
+
+156
+00:11:11,040 --> 00:11:14,900
+يعني هو جديد باكتشافه باعتباره وبالتالي ماعناش
+
+157
+00:11:14,900 --> 00:11:18,520
+معرفة كبيرة بالنسبة لأدينوفيروس احنا ذكرناها سابقا
+
+158
+00:11:18,520 --> 00:11:22,020
+انه حوالي اتنين واربعين zero types لان تعرف تلعب
+
+159
+00:11:22,020 --> 00:11:27,440
+الأمراض الأولاني polyomyelitis على رغم ان هي ايش
+
+160
+00:11:27,440 --> 00:11:30,860
+قلناها gastrointestinal infection لكن في الآخر
+
+161
+00:11:30,860 --> 00:11:34,420
+بتروح على ال nerve و بتعمل polyomyelitis او شلل
+
+162
+00:11:34,420 --> 00:11:39,710
+الأطفالاتنين و تلاتة بيعملوا meningitis هذا ال ..
+
+163
+00:11:39,710 --> 00:11:43,530
+ال .. ال very .. very common و most important يعني
+
+164
+00:11:43,530 --> 00:11:48,530
+خلّيني نقول prominent finding of the disease ال
+
+165
+00:11:48,530 --> 00:11:51,830
+hepatitis ايه؟ Hepatitis و انا قبل ما اجيكوا كان
+
+166
+00:11:51,830 --> 00:11:55,030
+احد الطلاب يسألني يقول دكتور طب مدام ال .. ال
+
+167
+00:11:55,030 --> 00:11:59,610
+hepatitis viruses واحد من ال DNA virus و واحد من
+
+168
+00:11:59,610 --> 00:12:02,450
+ال RNA و كل واحد شكل ليه احنا حاطينه في مجموعة
+
+169
+00:12:02,450 --> 00:12:10,990
+واحد؟ولماذا هناك فيروسات بتصيب الكبد ولم تحسب مع
+
+170
+00:12:10,990 --> 00:12:15,830
+الهيباطيتس فيروس؟ يبقى في انديان سؤالين ليش هم
+
+171
+00:12:15,830 --> 00:12:19,250
+مختلفين وحطيناهم في مجموعة واحدة وليش اخرين
+
+172
+00:12:19,250 --> 00:12:22,430
+بيعملوا الهيباطيتس ومحطيناهم مش مع هذه المجموعة
+
+173
+00:12:22,430 --> 00:12:29,250
+تعالوا نعرف الهيباطيتس فيروس their main and only
+
+174
+00:12:29,250 --> 00:12:34,980
+target is the liverيعني مافيش عندهم أماكن أخرى
+
+175
+00:12:34,980 --> 00:12:39,520
+يعملوها infection فقط في وين؟ في ال liver هدول
+
+176
+00:12:39,520 --> 00:12:43,300
+اللي Hepatitis و Viruses طب مش ضمنهم مع بعض، فى
+
+177
+00:12:43,300 --> 00:12:46,320
+مشكلة عندنا حقيقية لما بيكون واحد عنده Hepatitis
+
+178
+00:12:46,320 --> 00:12:50,680
+بقى بنتفرج نعرف إنها A ولا B ولا C ولا D إلا من
+
+179
+00:12:50,680 --> 00:12:55,740
+خلال فحوصات يبقى بتشابه تشابه كبير طيب معرفتنا
+
+180
+00:12:55,740 --> 00:12:59,660
+بنوع ال virus هل مهم بالنسبة لنا؟ أكيد مهم، عرفيه
+
+181
+00:12:59,660 --> 00:13:04,900
+ليش مهم؟مش بس موضوع علاج، لأ موضوع وقايا، موضوع
+
+182
+00:13:04,900 --> 00:13:11,080
+monitoring، لأن مثلا A و E هدولة جروح لحالهم،
+
+183
+00:13:11,080 --> 00:13:15,600
+بينما B و C ممكن يتحول ل chronic infection و ممكن
+
+184
+00:13:15,600 --> 00:13:18,720
+ال chronic infection هدولة يكونوا carrier و يكونوا
+
+185
+00:13:18,720 --> 00:13:23,260
+infectious للآخرينوممكن البعض منهم يتحول إلى liver
+
+186
+00:13:23,260 --> 00:13:27,800
+cancer liver cancer إذا معرفتنا بنوع ال virus مهم
+
+187
+00:13:27,800 --> 00:13:31,160
+جدا ليش ال other viruses اللي بتصيب ال liver
+
+188
+00:13:31,160 --> 00:13:36,080
+ماحطناش مع هذه المجموعة إذا كانت بتصيب أعضاء أخرى
+
+189
+00:13:36,080 --> 00:13:41,400
+مابنحطهاش مع ال hepatitis virus إذا خصصنا ال
+
+190
+00:13:41,400 --> 00:13:46,140
+hepatitis viruses إلى تلك التي فقط تصيب مين اللي
+
+191
+00:13:46,140 --> 00:13:51,190
+هو تلكبالنسبة للباجين كلهم كانوا عملوا دياري ال
+
+192
+00:13:51,190 --> 00:13:53,630
+rotavirus و ال norwalk و ال adenovirus كانوا
+
+193
+00:13:53,630 --> 00:13:57,930
+مسببين للدياري بالنسبة لل نوكليك أسد كلهم RNA معدى
+
+194
+00:13:57,930 --> 00:14:03,170
+ال adenovirus اذا الشيء المشترك بينهم انهم non
+
+195
+00:14:03,170 --> 00:14:08,050
+enveloped viruses صح؟ non enveloped virus لكن لحظة
+
+196
+00:14:08,050 --> 00:14:12,030
+كلهم تبعين كمان مرة او معروفين تبعين لمين؟ لل RNA
+
+197
+00:14:12,030 --> 00:14:14,970
+مش ل ال DNA واحد فقط من ال DNA virus
+
+198
+00:14:17,600 --> 00:14:22,440
+طب نيجي لل انترو فيروس وبالاخره ال polyovirus
+
+199
+00:14:26,850 --> 00:14:30,950
+الدزيز اللى بتسببه هذا الفيروس اسمه poliomyelitis
+
+200
+00:14:30,950 --> 00:14:35,870
+أو بالعربية شلل الأطفال او الشلل الشلل important
+
+201
+00:14:35,870 --> 00:14:40,150
+properties الفيروس بيصيب ال primates ال primates
+
+202
+00:14:40,150 --> 00:14:42,770
+اللى هم الأوليات اللى هى الأرقى الثديات اللى بيقول
+
+203
+00:14:42,770 --> 00:14:48,050
+عنها الإنسان و القرود ال apes اللى هى الغريلات و
+
+204
+00:14:48,050 --> 00:14:52,100
+القرود الأخرىطبعا هذا بيصيبهم مش بعد الحاجة ان هم
+
+205
+00:14:52,100 --> 00:14:54,280
+ال natural host، ال natural host هو فقط من
+
+206
+00:14:54,280 --> 00:14:58,060
+الإنسان، لكن ال virus قد يصيب .. يعني لو احنا
+
+207
+00:14:58,060 --> 00:15:02,790
+experimentally يمكن نصيب في هذه المخلوقاتالـ RNA
+
+208
+00:15:02,790 --> 00:15:05,490
+تبعه لأنه هناك و إنه بوصت في سنسه هو infectious
+
+209
+00:15:05,490 --> 00:15:08,490
+فيه three physiological type وهذا الكلب عرفناه من
+
+210
+00:15:08,490 --> 00:15:14,030
+الجدول based on different antigenic component على
+
+211
+00:15:14,030 --> 00:15:16,690
+الكبسيد تبعه اللي عامفش ياخدوا بالك هو envelope
+
+212
+00:15:16,690 --> 00:15:20,250
+مافيش envelope فأي antigenic تبعها تكون على
+
+213
+00:15:20,250 --> 00:15:23,410
+الكبسيد لما بيكون في envelope لما بيكون في
+
+214
+00:15:23,410 --> 00:15:26,390
+envelope بيتكلم عن ال envelope لما مايكونش في
+
+215
+00:15:26,390 --> 00:15:31,670
+envelope بيتكلم عن مين عن الكبسيد itselfزي ما
+
+216
+00:15:31,670 --> 00:15:34,670
+حكينا مافيش cross-reaction بين السترانز وبالتالي
+
+217
+00:15:34,670 --> 00:15:38,330
+الإنسان اللي بيصاب واحد بيوفرش حماية للأخرين أو
+
+218
+00:15:38,330 --> 00:15:41,250
+الأتنين الأخرين بينتقل عبر الفكال oral route
+
+219
+00:15:41,250 --> 00:15:46,170
+ودعوني أذكر هنا بنقطة أو بقضية مهمة في موضوع ال
+
+220
+00:15:46,170 --> 00:15:49,520
+transmission اللي هو الفكال oral routeطب الهدا ما
+
+221
+00:15:49,520 --> 00:15:54,640
+بنعزو انخفاض نسب الإصابة مثلا في عملاء الفيروسية
+
+222
+00:15:54,640 --> 00:15:58,080
+زي لل vaccine، مظهر؟ بنقول أن ال vaccine حسن من ..
+
+223
+00:15:58,080 --> 00:16:01,740
+هذا كلام صحيح، لكن اللي بيحسن أكتر من ال vaccine
+
+224
+00:16:01,740 --> 00:16:06,380
+هو ال improvement في ال .. و ال proper sewage
+
+225
+00:16:06,380 --> 00:16:11,380
+disposal، تخلص الأمن منين؟ من المياه العادمة،
+
+226
+00:16:11,380 --> 00:16:15,650
+المياه العادمةوبيعطيكوا بس بعض ال .. يعني اللامحات
+
+227
+00:16:15,650 --> 00:16:20,530
+عن تاريخيا في غزة النهارة، قبل عشرين سنة كنا نعمل
+
+228
+00:16:20,530 --> 00:16:23,510
+testing لعينات ال stool من بعض المناطق، بتنشأتكوا
+
+229
+00:16:23,510 --> 00:16:28,340
+المناطق، بيزعلوا صحابهافكنا نجد فيها نسب الإصابة
+
+230
+00:16:28,340 --> 00:16:32,520
+بالبرأة زي طريقة مثال زي ال Ascaris زي ال Guardia
+
+231
+00:16:32,520 --> 00:16:35,280
+و ال Amoeba و ال Mixed Infection نكون تلاقي تلاتة
+
+232
+00:16:35,280 --> 00:16:39,240
+أو اتنين مع بعض في نفس العينة كانت نسب كبيرة في
+
+233
+00:16:39,240 --> 00:16:42,680
+بعض المناطق لما جينا التلانة على المناطق هذه لجينا
+
+234
+00:16:42,680 --> 00:16:46,240
+ان الفرق بينها و بين المناطق الأخرى ان مافيش فيها
+
+235
+00:16:46,240 --> 00:16:49,640
+sewage system مافيش فيها أنظمات ضخمة جارية كانت
+
+236
+00:16:49,640 --> 00:16:53,380
+بتنده عالمين على الحفر اللي بيحفروها و يتخلصوا من
+
+237
+00:16:53,380 --> 00:16:56,520
+النفاة المنزليةوكل ما يتعبى يتصلوا في البلدية
+
+238
+00:16:56,520 --> 00:17:00,400
+يتيجي يتخلصهم من هذا ال .. طبعا الشوارع كانت غير
+
+239
+00:17:00,400 --> 00:17:03,980
+مرصوفة ايضا فكانت نسبة النفايات والمياه العادى ما
+
+240
+00:17:03,980 --> 00:17:08,220
+تصل للشوارع ففي هذه الحالة عملية الانتقال كانت
+
+241
+00:17:08,220 --> 00:17:13,370
+سهلة جدا فيها ال oral transmissionلأن لما نفس
+
+242
+00:17:13,370 --> 00:17:16,910
+المنطقة صار فيها sewage system والشوارع تباتها
+
+243
+00:17:16,910 --> 00:17:22,490
+رُصفت أصبحت هذه المنطقة أقل إصابة من مناطق أخرى
+
+244
+00:17:22,490 --> 00:17:26,590
+كانت في السابق تُعرف عليها يعني من أرقى المناطق
+
+245
+00:17:26,590 --> 00:17:30,300
+وأنضف المناطقيبقى الفارق اللي .. اللي حصل ما ..
+
+246
+00:17:30,300 --> 00:17:32,440
+ماعملنا vaccine جديد للبرزايس، مافيش vaccine
+
+247
+00:17:32,440 --> 00:17:36,460
+للبرزاية، تمام؟ كل اللي صار انه بس حسننا ال
+
+248
+00:17:36,460 --> 00:17:40,200
+storage disposal و غطينا الشوارع، غطينا الشوارع من
+
+249
+00:17:40,200 --> 00:17:43,540
+ال .. من ال .. من الأطفال، ما بتبولوش، بتبرزوش في
+
+250
+00:17:43,540 --> 00:17:46,960
+هذه المناطق وبتالي مافيهش transmission، والمياه
+
+251
+00:17:46,960 --> 00:17:51,570
+العادية ما بطلت تصل هذه الشوارعإذا الفيكل oral
+
+252
+00:17:51,570 --> 00:17:56,170
+transmission حله الرئيسي هو proper sewage
+
+253
+00:17:56,170 --> 00:18:01,670
+treatment أو disposal and treatment و public
+
+254
+00:18:01,670 --> 00:18:05,770
+health يعني خلّيني نقول measures sanitation نضافة
+
+255
+00:18:05,770 --> 00:18:10,290
+عامة و نضافة شخصية هدول التلات حلول حتى في غياب
+
+256
+00:18:10,290 --> 00:18:13,250
+الفاكسين قد يساعدوا في خفض اللي هو الإصابة
+
+257
+00:18:13,250 --> 00:18:16,430
+بالأمراض المنتقلة عن طريق الفيكل oral route والذي
+
+258
+00:18:16,430 --> 00:18:18,330
+يعتبر ال polio أحدها
+
+259
+00:18:27,840 --> 00:18:31,100
+النظافة العامة متمثلة في الأشياء اللي ذكرناها
+
+260
+00:18:31,100 --> 00:18:35,400
+بتساعد كتير it can replicate in the oropharynx and
+
+261
+00:18:35,400 --> 00:18:37,960
+intestinal tract human are the only natural host
+
+262
+00:18:37,960 --> 00:18:42,900
+successful vaccines has eradicated the disease
+
+263
+00:18:42,900 --> 00:18:47,550
+from the united states andindeed from the entire
+
+264
+00:18:47,550 --> 00:18:52,310
+western hemisphere نصف الكورة العرضية الغربي تم
+
+265
+00:18:52,310 --> 00:18:57,710
+تحلص من هذا الفيروسالحياة النادية اللتي حدثت في
+
+266
+00:18:57,710 --> 00:19:03,730
+الولايات المتحدة حدثت من أمثلة كالتالي واحد وناس
+
+267
+00:19:03,730 --> 00:19:08,490
+تعرضوا ل ال virus revertant of the attenuated
+
+268
+00:19:08,490 --> 00:19:13,630
+virus كلكوا تذكروا الأيوب أو مش الأيوب المخاوف
+
+269
+00:19:13,630 --> 00:19:18,910
+اللتي تحدثنا عنها من ال live attenuated اللي هو ال
+
+270
+00:19:18,910 --> 00:19:24,010
+live vaccineأحد هذه المخاوف انه يتحول من
+
+271
+00:19:24,010 --> 00:19:27,570
+attenuated إلى ال wild type او ال active type
+
+272
+00:19:27,570 --> 00:19:30,950
+حالات حدثت في الولايات المتحدة من تعرض ناس ل
+
+273
+00:19:30,950 --> 00:19:37,010
+revertant رقم اتنين و ناس مش مطعمين ذهبوا الى
+
+274
+00:19:37,010 --> 00:19:40,630
+اماكن موبوءة و اتعرضوا لل wild type ال wild type
+
+275
+00:19:40,630 --> 00:19:44,870
+هو ال بيروس مش المضعف ال wild يعني بري اللي هو
+
+276
+00:19:44,870 --> 00:19:48,130
+الحقيقي ال .. ال .. ال attenuated هو اللي استقبلنا
+
+277
+00:19:48,130 --> 00:19:52,960
+في مين؟في ال vaccine فهو مش مطعم طفل مثلا ولد في
+
+278
+00:19:52,960 --> 00:19:56,600
+الولايات المتحدة ماتطعمش و سافر اهله على منطقة
+
+279
+00:19:56,600 --> 00:19:59,640
+موبوءة مثل باكستان او افغانستان لانه لان هم
+
+280
+00:19:59,640 --> 00:20:03,040
+الدولتان الواحدتان اللي عملوا تقرير السنة الماضية
+
+281
+00:20:03,040 --> 00:20:07,400
+انه ما زال فيهم polio myelitis ففي هذه الحالة ممكن
+
+282
+00:20:07,400 --> 00:20:11,920
+ينتقل اليهم اللي هو الفيروسلما .. قبل ما بيستخدم
+
+283
+00:20:11,920 --> 00:20:18,540
+ال vaccine كانت الاوبيه تحدث في الصيف و في الخريف
+
+284
+00:20:18,540 --> 00:20:23,650
+ال fall معناها خريف مخطوط فيها خريفكما ذكرتلكم
+
+285
+00:20:23,650 --> 00:20:26,870
+المنظمة الصحية العالمية حاولت انها تحط هدف ان في
+
+286
+00:20:26,870 --> 00:20:31,710
+ال 2005 بحيث عام 2005 انها تنهي من اللي هو ال
+
+287
+00:20:31,710 --> 00:20:36,910
+polio myelitis لكن للأسف في 2007 كان هناك 16 دولة
+
+288
+00:20:36,910 --> 00:20:42,350
+ما زال فيها polio الا ان نسبة الإصابات انخفضت يعني
+
+289
+00:20:42,350 --> 00:20:45,630
+الجهود اللي بودرت ما راحتها بقى صحيح ما زال فيه
+
+290
+00:20:45,630 --> 00:20:50,130
+polio لكن الناس بقى اتطلعوا في العام 1988 و هذا ال
+
+291
+00:20:50,130 --> 00:20:53,900
+vaccine كان موجود يعنيكان فيه حوالي أكتر من ربع
+
+292
+00:20:53,900 --> 00:20:58,520
+مليون حالة سنوية worldwide طيب في العام الفين و
+
+293
+00:20:58,520 --> 00:21:02,220
+خمسة كان العدد أقل من جداش من الفين في العام الفين
+
+294
+00:21:02,220 --> 00:21:05,040
+و ستة عشر اللي هو العام المنصرم كان العدد أقل من
+
+295
+00:21:05,040 --> 00:21:07,760
+مائة أظن ستة و تمانين أو ستة و ستين لا أذكر الرقم
+
+296
+00:21:07,760 --> 00:21:12,180
+لكن أقل بالتأكيد أقل من مائة حالة و من دولتان فقط
+
+297
+00:21:12,180 --> 00:21:16,380
+هنا جدش كانوا ستة عشر دولة الآن صاروا كدهاش دولتين
+
+298
+00:21:16,620 --> 00:21:20,120
+ومتوقع في الأعوام القادمة إذا بقي ال rhythm على ما
+
+299
+00:21:20,120 --> 00:21:25,580
+هو في نشاطنا في التطييم والتوية والمراقبة ان
+
+300
+00:21:25,580 --> 00:21:31,660
+بالفعل انه بحلول عام 2020 ان نكون خلصنا من ال poll
+
+301
+00:21:31,660 --> 00:21:36,920
+اذا لم نستطع نتخلص من ال poll، نتخلص من مين احنا
+
+302
+00:21:36,920 --> 00:21:38,860
+فقط؟ من ال small box
+
+303
+00:21:41,280 --> 00:21:44,720
+بعد ما بتكاتر الفيروس بنات في ال .. ال .. ال .. ال
+
+304
+00:21:44,720 --> 00:21:44,860
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+305
+00:21:44,860 --> 00:21:45,560
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+306
+00:21:45,560 --> 00:21:45,860
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+307
+00:21:45,860 --> 00:21:48,540
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+308
+00:21:48,540 --> 00:21:53,280
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+309
+00:21:53,280 --> 00:21:58,820
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+310
+00:21:58,820 --> 00:21:59,380
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+311
+00:21:59,380 --> 00:22:02,560
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+312
+00:22:10,520 --> 00:22:13,360
+بسموه innervating يعني بي بي بي بي بي بي بي بي بي
+
+313
+00:22:13,360 --> 00:22:13,500
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+314
+00:22:13,500 --> 00:22:13,620
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+315
+00:22:13,620 --> 00:22:19,560
+بي بي بي بي بي بي بي بي بي بي بي بي
+
+316
+00:22:19,560 --> 00:22:23,080
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+317
+00:22:23,080 --> 00:22:26,200
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+318
+00:22:26,200 --> 00:22:29,260
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+319
+00:22:29,260 --> 00:22:36,540
+بي ب
+
+320
+00:22:39,480 --> 00:22:45,260
+من القرن الماضي كانت شائع ان نشوف اطفال من جيلنا
+
+321
+00:22:45,260 --> 00:22:50,100
+او اكبر مننا تمام انهم يكونوا عندهم شلل او بيعانوا
+
+322
+00:22:50,100 --> 00:22:56,650
+من شلل في احد الأطراف من ناتج عنأنا حتى لما بعرف
+
+323
+00:22:56,650 --> 00:23:00,030
+بعض الأشخاص يعني من السن تبقى يعني أكبر شوية
+
+324
+00:23:00,030 --> 00:23:05,690
+مصابين بهذا المرض الخبيث والذي يعني أنا كتبت عنه
+
+325
+00:23:05,690 --> 00:23:08,990
+مقالة من ضمن المقالات اللي كنت أكتبها في سلسلة
+
+326
+00:23:08,990 --> 00:23:12,350
+اسمها ميكروبات صنعت لها مكانا في التاريخ فهذا
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+327
+00:23:12,350 --> 00:23:16,450
+الميكروب من الميكروبات اللي كان يثير القشعريرة في
+
+328
+00:23:16,450 --> 00:23:20,710
+.. عندما يسمع الإنسان باسمه لإنه على الرغم من إنه
+
+329
+00:23:21,350 --> 00:23:26,210
+نسبة إحداثه لشلل الأطفال في الناس المصابين قليلة
+
+330
+00:23:26,210 --> 00:23:31,450
+جدا إلا إنها للنسبة لانه debilitating شلل مش حاجة
+
+331
+00:23:31,450 --> 00:23:37,770
+يعني فقد مثلا سماع في أذن أو كده لأ الآن هو مشلول
+
+332
+00:23:37,770 --> 00:23:42,710
+هذا يعني complicated خطيرة على الإنسان رقم اتنين
+
+333
+00:23:42,710 --> 00:23:48,000
+فيه كمان نسبة وفيات لاباسة بهالأنه بيدمر ال brain
+
+334
+00:23:48,000 --> 00:23:53,420
+stem و ال brain stem مسئولة عن بعض الحركات
+
+335
+00:23:53,420 --> 00:23:59,540
+اللايرادية زي التنفس فإذا ضربت ال brain stem بيضرب
+
+336
+00:23:59,540 --> 00:24:03,740
+التنفس وبتالي بيموت المريض من respiratory failure
+
+337
+00:24:05,760 --> 00:24:09,760
+الـ Paralysis بينتج عن هذا المرأة اللي ممكن نادى
+
+338
+00:24:09,760 --> 00:24:11,800
+الجملة الأخيرة، death of these cells result in
+
+339
+00:24:11,800 --> 00:24:14,820
+paralysis of the muscle innervated by those
+
+340
+00:24:14,820 --> 00:24:17,540
+neurons وبالتالي بيصير لنا شرع اللي جونا عنه
+
+341
+00:24:17,540 --> 00:24:23,470
+الإرتخاءالـ Plasma Stem زي ما حكينا بيدّي لغير الـ
+
+342
+00:24:23,470 --> 00:24:26,610
+Poliomyelitis بالاضافة لـ Respiratory Paralysis
+
+343
+00:24:26,610 --> 00:24:29,930
+اللي هو الشلل في عضوات اللي هو الجهاز التنفسي
+
+344
+00:24:29,930 --> 00:24:34,470
+المناعة والاستجابة المناعية لهذا ال .. ال بيروس
+
+345
+00:24:34,470 --> 00:24:39,670
+غالبا تتشكل من شغلتين أساسيتين اللي هم Intestinal
+
+346
+00:24:39,670 --> 00:24:43,710
+IgA وهذا مهم جدا للـ Intestinal IgA بالاضافة إلى
+
+347
+00:24:43,710 --> 00:24:50,810
+Humoral اللي هو الـ IgGهذه المناعة تعطي lifelong
+
+348
+00:24:50,810 --> 00:24:54,530
+immunity وهي specific جنة للهستريني اللي بسبب
+
+349
+00:24:54,530 --> 00:25:00,230
+المرض الان تعالوا نطلع المرض ايه أشكاله في الإنسان
+
+350
+00:25:00,230 --> 00:25:06,110
+هو polyomyelitis لكن اطلعوا مقسم إلى أربع أصناف
+
+351
+00:25:07,210 --> 00:25:10,830
+تسعة وتسعين بالمائة من الصنف الأول ايش هو
+
+352
+00:25:10,830 --> 00:25:13,670
+inapparent يعني تسعة وتسعين بالمائة من الناس اللي
+
+353
+00:25:13,670 --> 00:25:17,810
+بينصفوا ال polio لا يفر عليهم أي أعراض ال واحد في
+
+354
+00:25:17,810 --> 00:25:21,730
+المائة موزة على مين؟ على abortive وكلمة abortive
+
+355
+00:25:21,730 --> 00:25:26,910
+تعني mild form of the disease ايش mild form؟ شكل
+
+356
+00:25:26,910 --> 00:25:32,660
+بسيط من المرضالرقم تلاتي الـ Non-paralytic في عراب
+
+357
+00:25:32,660 --> 00:25:37,180
+و خاصة حملة و فيه ألم لكن الـ Non-paralytic لا
+
+358
+00:25:37,180 --> 00:25:42,560
+تؤدي إلى شلل الرابعة وهي الأقل اللي هي Paralytic
+
+359
+00:25:42,560 --> 00:25:46,620
+Poliomyelitis إذا Inapparent, abortive, Non
+
+360
+00:25:46,620 --> 00:25:50,740
+-paralytic and Paralytic Poliomyelitis مين ال most
+
+361
+00:25:50,740 --> 00:25:55,800
+common؟الأولى Asymptomatic infection is quite
+
+362
+00:25:55,800 --> 00:25:59,700
+common. Roughly only one percent of infections are
+
+363
+00:25:59,700 --> 00:26:03,860
+clinically apparent يبقى ال clinically apparent هم
+
+364
+00:26:03,860 --> 00:26:08,240
+التلاتة الباجين يبقى كل ال ال ال واحد في المية
+
+365
+00:26:08,240 --> 00:26:11,560
+بشكل التلاتة لسه في ياندي اللي هم ال abortive اللي
+
+366
+00:26:11,560 --> 00:26:14,800
+هي ال mild form و ال non paralytic و الأخيرة اللي
+
+367
+00:26:14,800 --> 00:26:18,940
+هي ال paralytic poliomyelitisالـ incubation period
+
+368
+00:26:18,940 --> 00:26:23,860
+من عشرة إلى أربعة عشر يوم الـ most common form هو
+
+369
+00:26:23,860 --> 00:26:27,760
+الـ abortive poliomyelitis which is a mild febrile
+
+370
+00:26:27,760 --> 00:26:31,100
+كلمة febrile يعني فيه سخونة في حرارة illness
+
+371
+00:26:31,100 --> 00:26:34,680
+characterized by headache, sore throat, nausea and
+
+372
+00:26:34,680 --> 00:26:41,500
+vomiting معظم المرضى بيشوفوا تلقائي بدون حتى تدخل
+
+373
+00:26:41,500 --> 00:26:46,740
+لأ supportive treatment ولا غيره بيشوفوا تلقائيالـ
+
+374
+00:26:46,740 --> 00:26:51,540
+Non-paralytic poliomyelitis manifests as aseptic
+
+375
+00:26:51,540 --> 00:26:55,220
+meningitis، إذا بدكوا تلاحظوا الآن إنه صار عندنا
+
+376
+00:26:55,220 --> 00:27:00,200
+أربعة meningitis اللي أنتم دراستهم، هدهم كمان مرة
+
+377
+00:27:00,200 --> 00:27:06,480
+الأساسيات مامس، ايكوفيروس، كوكساكي فيروس ويعني هنا
+
+378
+00:27:06,480 --> 00:27:10,220
+اللي هو ال poliomyelitis virus
+
+379
+00:27:13,090 --> 00:27:15,910
+استفنك اللي طلع على الستفنك انتوا عارفين هي اصلا
+
+380
+00:27:15,910 --> 00:27:20,210
+عرب من عرب من ال meningitis الستفنك اللي هي الرقبة
+
+381
+00:27:20,210 --> 00:27:25,230
+المتصلبة رقبة المتصلبة برضه this infection resolve
+
+382
+00:27:25,230 --> 00:27:29,750
+spontaneously المشكلة اللي هتميناها الآن في الرابع
+
+383
+00:27:29,750 --> 00:27:33,690
+اللي هي ال paralytic poliomyelitis which causes
+
+384
+00:27:33,690 --> 00:27:38,600
+flaccid paralysis is the prominent findingكمان ال
+
+385
+00:27:38,600 --> 00:27:42,360
+brain stem involvement كان ممكن يؤدي إلى جنة اللي
+
+386
+00:27:42,360 --> 00:27:47,540
+هو الفشل في عملية التنفس وهذا مهدد لحياة الإنسان
+
+387
+00:27:47,540 --> 00:27:51,980
+في الزمن اللي كان البوليو منتشر اضطروا يخترعوا
+
+388
+00:27:51,980 --> 00:27:55,780
+كابسولات حديديعني يحطوا فيها المريض عشان يشكلوا
+
+389
+00:27:55,780 --> 00:28:01,740
+فيها ضغط يعني جهاز كهربائي يضغط صدر المريض فيخرج
+
+390
+00:28:01,740 --> 00:28:07,160
+الهواء ثم يعني يفرج الضغط فيضطر المريض ياخد الهواء
+
+391
+00:28:07,160 --> 00:28:10,520
+يعني وكانوا تنفس صناعي تنفس صناعي اليوم الأجزة
+
+392
+00:28:10,520 --> 00:28:14,740
+التنفس الصناعي أصبحت يعني في المتناول اليد مش زي
+
+393
+00:28:14,740 --> 00:28:19,570
+التعقيدات الساجقة يعني صارت أفضل من دي قبلطبعا هذا
+
+394
+00:28:19,570 --> 00:28:24,350
+الجهاز كان يبقى المريض فيه ممكن سنة سنتين و في
+
+395
+00:28:24,350 --> 00:28:29,810
+غالب الأمر يموت فكانوا يعني محاولة
+
+396
+00:28:29,810 --> 00:28:34,030
+من قبل الأطباء او الأهل انهم يعني يبقوا مريضهم
+
+397
+00:28:34,030 --> 00:28:38,710
+طبعا و هناك ايضا معانا شديدة لانه في انقباضات
+
+398
+00:28:38,710 --> 00:28:42,570
+asbestic painful asbestic
+
+399
+00:28:45,160 --> 00:28:47,800
+painful muscle spasm زي ما حكينا هنا painful
+
+400
+00:28:47,800 --> 00:28:52,100
+muscle spasm also occur وزي ما حكينا لكوا ال motor
+
+401
+00:28:52,100 --> 00:28:56,180
+nerve damage بيكون permanent في أصلا عندنا nerve
+
+402
+00:28:56,180 --> 00:28:59,900
+damage مش permanent كل ال nerve damage بيكون
+
+403
+00:28:59,900 --> 00:29:04,100
+permanent لكن بيقولنا انه بعد ما بيشفى المريض إذا
+
+404
+00:29:04,100 --> 00:29:08,380
+شفيا شفيا المريض وصار عنده شلل في الأول بيكون
+
+405
+00:29:08,380 --> 00:29:14,320
+الحركة ضعيفة خالصلكن بيصير في بعض التحسن في الحركة
+
+406
+00:29:14,320 --> 00:29:19,260
+لإنه يبدو إن الخلايا السليمة اللي موجودة بتاخد دور
+
+407
+00:29:19,260 --> 00:29:23,900
+الخلايا لكن لا يعود اللي هو المريض كما كان من
+
+408
+00:29:23,900 --> 00:29:29,340
+دقيقة قبل، في مصطلحين لازم نعرفهمللتعبير عن المدى
+
+409
+00:29:29,340 --> 00:29:33,100
+الأعضاء اللى صارت involved في الالتهاب مثلا لما
+
+410
+00:29:33,100 --> 00:29:36,700
+بنقول meninges بنقول meningitis ولا لأ لكن لو كان
+
+411
+00:29:36,700 --> 00:29:41,440
+meninges و brain برانكما بنقول meningoencephalitis
+
+412
+00:29:41,440 --> 00:29:43,780
+لما يكون التنين مع بعض involved يعني صار فيهم
+
+413
+00:29:43,780 --> 00:29:48,060
+inflammation meningoencephalitisإذا الـ spinal
+
+414
+00:29:48,060 --> 00:29:50,960
+cord كمان مصاب، إيش بنقول؟
+
+415
+00:29:50,960 --> 00:29:54,520
+meningomyeloencephalitis، ولا حاجة، مافيش يعني
+
+416
+00:29:54,520 --> 00:29:59,200
+نضيف مقاطع، بس meningomyeloencephalitis،
+
+417
+00:29:59,200 --> 00:30:04,930
+is often used كمصطلحالـ lab diagnosis لهذا الفيروس
+
+418
+00:30:04,930 --> 00:30:10,010
+يتم عبر عزل الفيروس أو من خلال ارتفاع في تركيز الـ
+
+419
+00:30:10,010 --> 00:30:14,110
+antibody-titer اللي بنعرفه دائما الفيروس ممكن يعزل
+
+420
+00:30:14,110 --> 00:30:18,150
+من الـ throat من الستول و من ال spinal fluid من
+
+421
+00:30:18,150 --> 00:30:23,800
+خلال زرع هذه العينات إلى cell culturesالفيروس
+
+422
+00:30:23,800 --> 00:30:29,400
+بيسبب الـcytopathic effect وممكن نتعرف على الفيروس
+
+423
+00:30:29,400 --> 00:30:33,700
+من خلال الـneutralization للـcytopathic effect
+
+424
+00:30:33,700 --> 00:30:37,720
+with specific antibodies يعني عندي antibody تلاتة
+
+425
+00:30:37,720 --> 00:30:41,580
+للواحد والاتنين وتلاتة اللي هم تلاتة strains الآن
+
+426
+00:30:41,580 --> 00:30:44,320
+الفيروس أنا منميه عامل الـcytopathic effect هذا
+
+427
+00:30:44,320 --> 00:30:47,030
+الـcytopathic effect يمكن يكون لأخر الفيروسأكيد
+
+428
+00:30:47,030 --> 00:30:51,250
+بدي أعرف إنه للـ poliovirus بروح بحط عليه أول حاجة
+
+429
+00:30:51,250 --> 00:30:57,030
+التلات antibodies إذا التلات antibodies منعوا ال
+
+430
+00:30:57,030 --> 00:31:01,770
+virus يبقى هو poliovirus إذا بدي أعرف أنه سلالة
+
+431
+00:31:01,770 --> 00:31:05,440
+منهمبأفحصه على ثلاثة cell cultures وبحط على ال
+
+432
+00:31:05,440 --> 00:31:09,020
+cell culture الأولى Antibody X Antibody Y Antibody
+
+433
+00:31:09,020 --> 00:31:13,640
+Z وبشوف وين مانع عشان أعرف بالضبط إيش نوع السلالة
+
+434
+00:31:13,640 --> 00:31:16,820
+يبقى بنجر أتعرف على ال virus من خلال ال inhibition
+
+435
+00:31:16,820 --> 00:31:23,160
+لل cytopathic effect with specific antibodiesطبعا
+
+436
+00:31:23,160 --> 00:31:26,080
+specific antisera نفس المعنى أه، antisera أو
+
+437
+00:31:26,080 --> 00:31:28,460
+antibody نفس المعنى treatment there is no
+
+438
+00:31:28,460 --> 00:31:32,020
+antiviral therapy treatment is limited to
+
+439
+00:31:32,020 --> 00:31:35,580
+symptomatic relief and respiratory support زي ما
+
+440
+00:31:35,580 --> 00:31:39,420
+حكينا اللي هي الفحال فشل اللي هو الجهاز التنفسي if
+
+441
+00:31:39,420 --> 00:31:44,200
+neededفيزيو ثيرابي اللي هو العلاج الطبيعي for the
+
+442
+00:31:44,200 --> 00:31:47,300
+affected muscles is important بعد الشفاء بيتم
+
+443
+00:31:47,300 --> 00:31:51,120
+عملية اللي هو rehabilitation اللي هي اعادة تأهيل
+
+444
+00:31:51,120 --> 00:31:57,280
+للاطفال بيحسنه كده مرة بيرجعش normal لكن بيحسنه من
+
+445
+00:31:57,280 --> 00:31:59,680
+الأداء الحركي لهذه العضلة
+
+446
+00:32:02,580 --> 00:32:07,200
+البرفنشن بالاساس زي ما ذكرتلكوا انا اعتبر على ال
+
+447
+00:32:07,200 --> 00:32:10,000
+vaccine لكن ذكرتلكوا ملاحظة على ملاحظة اللي هي ال
+
+448
+00:32:10,000 --> 00:32:14,340
+sewage disposal هذه عامة جدا هناك نوعين من ال
+
+449
+00:32:14,340 --> 00:32:18,120
+vaccine واحد اسمه Salk واحد اسمه Sabine و هدولة
+
+450
+00:32:18,120 --> 00:32:21,720
+Sabine و Salk علماء هم اللي طوروا فلو نقول Salk
+
+451
+00:32:21,720 --> 00:32:25,320
+vaccine و Sabine vaccineهدولة اعتقد .. اعتقد ..
+
+452
+00:32:25,320 --> 00:32:27,640
+والله لأ انا مش فاكر .. مش متأكد انهم اخدوا جائزة
+
+453
+00:32:27,640 --> 00:32:31,580
+نوبل برضه في الطب الاكتشاف هم هدولة ال .. ايه؟
+
+454
+00:32:31,580 --> 00:32:36,020
+اللي هم ال .. ال .. ال vaccines لإنه كمرة ال virus
+
+455
+00:32:36,020 --> 00:32:40,100
+خطير قاتل له consequences سيئة ليها ال
+
+456
+00:32:40,100 --> 00:32:44,880
+polymyelitis وبتالي ان نلاقي حد يعطينا حل له هذا
+
+457
+00:32:44,880 --> 00:32:51,460
+شيء مميزIPV-OPV هو Intramuscular .. عفوا ..
+
+458
+00:32:51,460 --> 00:32:56,320
+Inactivated Polio Vaccine و Oral Vaccine اللي هو
+
+459
+00:32:56,320 --> 00:33:06,020
+OPV، إذا IPV و OPV، اتذكروا Killed Salkسالك قتل
+
+460
+00:33:06,020 --> 00:33:15,680
+صالك و سابين قتل
+
+461
+00:33:15,680 --> 00:33:21,860
+صالك
+
+462
+00:33:22,720 --> 00:33:28,300
+both vaccine induces humoral antibodies شوفت ان ال
+
+463
+00:33:28,300 --> 00:33:33,300
+immunity لهذا الفيروس مرتبط بشكل كبير بال IGA و
+
+464
+00:33:33,300 --> 00:33:38,240
+IGG يعني ماقولناش كتير عن مين عن ال cell mediated
+
+465
+00:33:38,240 --> 00:33:44,700
+immunity أكدنا على ال IGA و IGGwhy؟ which
+
+466
+00:33:44,700 --> 00:33:48,240
+neutralizes virus entering the blood and hence
+
+467
+00:33:48,240 --> 00:33:51,580
+prevents central nervous system infection أنا أصلا
+
+468
+00:33:51,580 --> 00:33:56,040
+خايف على أن الفيروس يصل وين يصل اللي هو ال central
+
+469
+00:33:56,040 --> 00:33:59,440
+nervous system فإذا اتكون antibody جوا الدم و
+
+470
+00:33:59,440 --> 00:34:02,680
+الفيروس جزء من انتقال ال central nervous system
+
+471
+00:34:02,680 --> 00:34:05,560
+لازم يمر عبر مين؟ عبر الدم فهذا بيعمله ال
+
+472
+00:34:05,560 --> 00:34:09,240
+neutralization فالدور الكبير لهذا الفيروس معتمد
+
+473
+00:34:09,240 --> 00:34:12,870
+على ال immunoleverboth the killed and live
+
+474
+00:34:12,870 --> 00:34:16,330
+vaccines contain all three zero types يعني هذا
+
+475
+00:34:16,330 --> 00:34:22,630
+سواء كان killed او live و بالمناسبة ما ذكرناه عن
+
+476
+00:34:22,630 --> 00:34:31,130
+ال advantage و disadvantage لاتنين موجودين طيب لان
+
+477
+00:34:31,130 --> 00:34:36,050
+بدنا نعمل مقارنة بين بين سالك killed او بين سبين
+
+478
+00:34:36,050 --> 00:34:39,590
+اللي هو liveprevent disease كيلهومه نعم بيعمل
+
+479
+00:34:39,590 --> 00:34:43,430
+prevention لل disease interrupt transmission لحظه
+
+480
+00:34:43,430 --> 00:34:48,110
+ال killed لأ بينما ال live نعم بيعمل interruption
+
+481
+00:34:48,110 --> 00:34:52,550
+لل transmission بينتقلش من الإنسان إلى إنسان يعني
+
+482
+00:34:52,550 --> 00:34:57,290
+بحميني أنا تمام و الفيروس ما هو أنا قلتلكم مرة مش
+
+483
+00:34:57,290 --> 00:35:01,170
+مش في ال intestinal tract بيصير تكاثر و بيصير له
+
+484
+00:35:01,170 --> 00:35:08,040
+excretion تمامليش ماعملش interruption؟ لأنه أصلا
+
+485
+00:35:08,040 --> 00:35:14,340
+ماقداش induction ل IGA أما هذا عمل فقط لمين؟ ل IG
+
+486
+00:35:14,340 --> 00:35:20,880
+.. هذا بتلاحظوا Induced Humoral IGG كلمة نعم بينما
+
+487
+00:35:20,880 --> 00:35:25,980
+ال IGA فقط مين؟ ال live vaccine afford secondary
+
+488
+00:35:25,980 --> 00:35:29,080
+protection by spread to others؟ No Yes بحاجة كده
+
+489
+00:35:29,080 --> 00:35:32,860
+برضه بنفس المعنى الترانزميشنInterfere with the
+
+490
+00:35:32,860 --> 00:35:35,100
+replication of virulent strains in the gut؟ No
+
+491
+00:35:35,100 --> 00:35:40,920
+لأنه ماعندوش كمان مرة IGA Yes إذا الان كل هذه
+
+492
+00:35:40,920 --> 00:35:44,700
+المزايا في صالح مين قلناها؟ في صالح ال life الان
+
+493
+00:35:44,700 --> 00:35:48,280
+Revert to virulence أكيد لأنه أنا ميت بينما هذا
+
+494
+00:35:48,280 --> 00:35:53,640
+yes لكن بنجو سين راري طبعا كلمة rarely هي إشارة
+
+495
+00:35:53,640 --> 00:35:57,480
+إلى الإحتمالية يعني احنا لنا سنوات نتكلم عن ال
+
+496
+00:35:57,480 --> 00:36:04,130
+vaccine مناسب او مناسبتين حدثوبالتالي كلمة Rebly
+
+497
+00:36:04,130 --> 00:36:08,470
+هي فقط إشارة للناس إن دلوقتي يا مصنعين، دلوقتي يا
+
+498
+00:36:08,470 --> 00:36:12,310
+مطعمين، بتكونوا تراقبوا إنتوا كمان ال vaccines
+
+499
+00:36:12,310 --> 00:36:17,110
+اللي بتصنعوه و اللي بتاعته بتكونوا تراقبوا هذا ال
+
+500
+00:36:17,110 --> 00:36:17,730
+vaccine
+
+501
+00:36:21,580 --> 00:36:24,440
+with other enterovirus may impair immunization،
+
+502
+00:36:24,440 --> 00:36:30,120
+إيش معنى impair؟ Imper يعني بيخرّب، تمام؟ هل لو
+
+503
+00:36:30,120 --> 00:36:33,540
+صار co-infection مع ال vaccine، أنا أخدت ال
+
+504
+00:36:33,540 --> 00:36:36,680
+vaccine و صار عندي انترك فيروس infection، هل بيعوق
+
+505
+00:36:36,680 --> 00:36:42,120
+أو بيفشل ال vaccination، بقولنا في الكل لأ بيعوجش،
+
+506
+00:36:42,120 --> 00:36:46,480
+ليش؟ أنا ماخده انترا مسكلةبينما الـ enteric virus
+
+507
+00:36:46,480 --> 00:36:50,700
+أو ال oral اللي هو ال live أخدناها oral وبالتالي
+
+508
+00:36:50,700 --> 00:36:55,320
+بالفعل ممكن يعملوا interference مع بعض Can cause
+
+509
+00:36:55,320 --> 00:36:58,940
+disease in the immune compromise؟ No بالنسبة
+
+510
+00:36:58,940 --> 00:37:04,580
+لكilled بينما yes بالنسبة ل life إذا ال juice اللي
+
+511
+00:37:04,580 --> 00:37:08,220
+هلوي واضح أنه اللي صالح مين ال life و ال juice
+
+512
+00:37:08,220 --> 00:37:09,860
+الشفلي صالح مين ال kill
+
+513
+00:37:12,980 --> 00:37:16,600
+Route of administration injection and oral التاني
+
+514
+00:37:16,600 --> 00:37:19,960
+oral اورال لان احنا بدنا يتكاثر جوا الأمهات ويعمل
+
+515
+00:37:19,960 --> 00:37:27,280
+induction ل ال IGA production Route
+
+516
+00:37:27,280 --> 00:37:30,020
+of administration oral خلصنا منها requires
+
+517
+00:37:30,020 --> 00:37:34,220
+refrigeration نو ال killed بينما ال life's a being
+
+518
+00:37:34,220 --> 00:37:39,650
+yesفاكرين الجثة اللى حكتكوا عن ال cold transport
+
+519
+00:37:39,650 --> 00:37:42,930
+chain فى ال vaccine ودالكوا ان ال vaccine لازم من
+
+520
+00:37:42,930 --> 00:37:46,950
+المصنع اللى طلع منه لحد ما يصل لمخازن تبعتنا لازم
+
+521
+00:37:46,950 --> 00:37:52,330
+يكون معاه شهادة بتقول انه مر بدرجة حرارة 22 و 21 و
+
+522
+00:37:52,330 --> 00:37:57,130
+نص 22 و نص يعني تاريخ مروره اسمها cold transport
+
+523
+00:37:57,130 --> 00:38:02,050
+chainفبالتالي في بعض ال vaccine من ميزاتها ان انا
+
+524
+00:38:02,050 --> 00:38:04,670
+بحطها على الراف عارفين اني بحطها على الراف ميزات؟
+
+525
+00:38:04,670 --> 00:38:09,090
+لأن التلاجة طاقة طب في غزة انها انا ايش من انا في
+
+526
+00:38:09,090 --> 00:38:12,090
+التلاجة اللي بتفصل؟ بدنا نشغلها المواطين؟ يعني
+
+527
+00:38:12,090 --> 00:38:17,450
+الابقاءها في ظرف ملائم لها في التخزين هذا أمر حيوي
+
+528
+00:38:17,450 --> 00:38:22,010
+وبالتالي هو أمر مكلف هو حيوي نعم وضروري لكن مكلف
+
+529
+00:38:23,570 --> 00:38:27,090
+Duration of immunity في الـ killed بتكون shorter و
+
+530
+00:38:27,090 --> 00:38:31,490
+بالـ live بتكون longer لإنه هي عبارة عن بناء
+
+531
+00:38:31,490 --> 00:38:37,890
+simulation ل natural infection يعني زي محاكاة لمرض
+
+532
+00:38:37,890 --> 00:38:41,190
+حقيقي احنا خدنا ال oral و صار فيه اندي infection و
+
+533
+00:38:41,190 --> 00:38:45,390
+يمكن وصل الدم كمان تمام لكن الفيروس ضعيف وبالتالي
+
+534
+00:38:45,390 --> 00:38:52,000
+تم التخلص منه تماماهذا الفيروس الأول في السلسلة
+
+535
+00:38:52,000 --> 00:38:57,280
+ننتقل الآن لفيروس تاني اسمه كوكساكي virus كوكساكي
+
+536
+00:38:57,280 --> 00:39:01,220
+virus are named for .. named for يعني سمية على اسم
+
+537
+00:39:01,220 --> 00:39:04,220
+اللي هو ال town of كوكساكي موجودة في نيو يورك
+
+538
+00:39:04,220 --> 00:39:08,700
+where they were first isolated يعني تم عزلها في
+
+539
+00:39:08,700 --> 00:39:12,760
+مدينة كوكساكي في منطقة نيو يورك وبالتالي سمية على
+
+540
+00:39:12,760 --> 00:39:19,940
+اسمها الكوكساكي virus بسبب مجموعة من الأمراضبينجسم
+
+541
+00:39:19,940 --> 00:39:25,620
+على group A و group Bالـ .. ال .. ال .. ال .. ال
+
+542
+00:39:25,620 --> 00:39:26,340
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+543
+00:39:26,340 --> 00:39:26,660
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+544
+00:39:26,660 --> 00:39:26,740
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+545
+00:39:26,740 --> 00:39:34,400
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+546
+00:39:34,400 --> 00:39:37,140
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+547
+00:39:37,140 --> 00:39:37,200
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+548
+00:39:37,200 --> 00:39:37,220
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+549
+00:39:37,220 --> 00:39:38,100
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+550
+00:39:38,100 --> 00:39:40,400
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+551
+00:39:40,400 --> 00:39:46,300
+.. ال .. ال .. ال .. ال .. ال
+
+552
+00:39:49,480 --> 00:39:55,500
+في كمان مرض للغاية سيّه اسمه hand, foot and mouth
+
+553
+00:39:55,500 --> 00:40:01,400
+disease بيطلع blisters بيطلع بيطلع بيطلع بيطلع
+
+554
+00:40:01,400 --> 00:40:02,660
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+555
+00:40:02,660 --> 00:40:02,720
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+556
+00:40:02,720 --> 00:40:18,600
+بيطلع بيطلع بيطل
+
+557
+00:40:18,640 --> 00:40:21,540
+طبعا هداك اللي .. اللي مولود في الأبقار حصل أنه
+
+558
+00:40:21,540 --> 00:40:24,220
+السنة الماضية أو اللي جابلها وحصل أنه قبل أدت
+
+559
+00:40:24,220 --> 00:40:28,980
+سنوات ونسبة القتل فيه للحيوانات بتكون عالية جدا،
+
+560
+00:40:28,980 --> 00:40:31,840
+يعني فيروس من الفيروسات اللي بيسميها الاقتصادية
+
+561
+00:40:31,840 --> 00:40:36,480
+بتأثر على اقتصاد ال .. البلد وخاصة أنه نتكلم عن
+
+562
+00:40:36,480 --> 00:40:42,940
+قطعان ماشية مكلفة أثمنجروب بي فيروس بتسبب حاجة
+
+563
+00:40:42,940 --> 00:40:49,200
+اسمها pleurodyna وينهدى عبارة عن pain عضلات بين
+
+564
+00:40:49,200 --> 00:40:55,500
+الأضلاع او في الديافرام الحجاب الحاجز myocarditis
+
+565
+00:40:55,500 --> 00:41:01,180
+و pericarditis اذا الكوكساكي فيروس غالبا بيسبب
+
+566
+00:41:01,180 --> 00:41:04,520
+مجموعتين من الأمرض بيسموها group a و group b
+
+567
+00:41:04,520 --> 00:41:06,700
+infection
+
+568
+00:41:09,810 --> 00:41:14,310
+Types cause nonspecific upper respiratory tract
+
+569
+00:41:14,310 --> 00:41:18,250
+disease, common cold, febrile rashes and aseptic
+
+570
+00:41:18,250 --> 00:41:18,790
+meningitis
+
+571
+00:41:39,830 --> 00:41:41,630
+نكمل باقي المجموعات
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ed8f730f0950c5a8a0066d27d23730f883e6fba3
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/R3NP37C3PS0_raw.srt
@@ -0,0 +1,2320 @@
+1
+00:00:20,990 --> 00:00:23,930
+فبسم الله الرحمن الرحيم اليوم موضوع جديد ان شاء
+
+2
+00:00:23,930 --> 00:00:28,550
+الله متعلق بال RNA non-enveloped viruses وهي
+
+3
+00:00:28,550 --> 00:00:33,010
+مجموعة أقل من التي سبقتها لكن بنركز فيها على
+
+4
+00:00:33,010 --> 00:00:36,650
+مجموعة غالبا ما تصيب ال gastrointestinal tract
+
+5
+00:00:36,650 --> 00:00:39,770
+البعض منها طبعا بصيب أماكن أخرى زي ال rhino virus
+
+6
+00:00:39,770 --> 00:00:43,170
+لكن المعظم بيأثر على ال gastrointestinal tract
+
+7
+00:00:43,170 --> 00:00:45,630
+الآن التأثير على ال gastrointestinal tract قد لا
+
+8
+00:00:45,630 --> 00:00:51,380
+يكونبشكل ديارية قد يكون بشكل شلل شلل زي مثلا ال
+
+9
+00:00:51,380 --> 00:00:54,820
+polio myelitis الكوكساكي فيروس و ال eco virus
+
+10
+00:00:54,820 --> 00:00:58,980
+درسناهم سابقا بيعملوا meningitis لكن بداية باتهم
+
+11
+00:00:58,980 --> 00:01:03,530
+من وين انتريك فيروس البعض الآخرزي ال Norwalk و ال
+
+12
+00:01:03,530 --> 00:01:07,710
+Rotavirus بيناله Diarrhea عند الإنسان طبعا ال
+
+13
+00:01:07,710 --> 00:01:13,570
+diagram هذا هو ليس فقط لهذا ال chapter و انما لكل
+
+14
+00:01:13,570 --> 00:01:18,170
+ال RNA viruses بيساعدنا في التعرف على الأفراد بناء
+
+15
+00:01:18,170 --> 00:01:22,720
+على بعض الخصائص المميزة مثلابنجسم احنا اللي هم
+
+16
+00:01:22,720 --> 00:01:26,880
+single-stranded RNA و double-stranded RNA، الـ
+
+17
+00:01:26,880 --> 00:01:29,340
+double-stranded RNA فيه فقط واحد اللي هو الريو
+
+18
+00:01:29,340 --> 00:01:32,600
+فايروس، بينما ال single-stranded هم الآخرين، فيه
+
+19
+00:01:32,600 --> 00:01:36,740
+عندي negative sense و فيه عندي positive senseفي
+
+20
+00:01:36,740 --> 00:01:39,840
+عندي segmented و non-segmented في عندي naked و
+
+21
+00:01:39,840 --> 00:01:44,080
+enveloped ال enveloped أيضا بنجسمه إلى icosahedral
+
+22
+00:01:44,080 --> 00:01:47,860
+و helical يعني بنقدر نعرف من اسم هذا اللي هو مثلا
+
+23
+00:01:47,860 --> 00:01:51,800
+زي ايش هذا coronavirus هو helical enveloped
+
+24
+00:01:51,800 --> 00:01:55,880
+positive sense single-stranded RNA virus يبقى
+
+25
+00:01:55,880 --> 00:02:00,210
+بيساعدنا في التعرف على الفيروسبينما الفيروسات في
+
+26
+00:02:00,210 --> 00:02:03,890
+هذه المحاضرة ستكون ان شاء الله موزعة على تلت أسماء
+
+27
+00:02:03,890 --> 00:02:08,390
+رئيسية اللي هي ال بيكورنا فيروس و الكليسي فيروس و
+
+28
+00:02:08,390 --> 00:02:12,930
+الريو فيروس الريو فيروس بتشمل الروتا فيروس الفيروس
+
+29
+00:02:12,930 --> 00:02:15,830
+الشهير اللي يحدث أسهال عند الأطفال بنسبة كبيرة في
+
+30
+00:02:15,830 --> 00:02:20,150
+العالم و هنا في فلسطين ايضا نحن لسنا باستثناء يعني
+
+31
+00:02:20,150 --> 00:02:24,610
+لدينا هذا الفيروسالكاريسي فيروس حقا مايعرف عن هذا
+
+32
+00:02:24,610 --> 00:02:27,030
+الفيروس في غزة يعني ماعنداش اي معرفة عن هذا
+
+33
+00:02:27,030 --> 00:02:31,110
+الفيروس في قطاع غزة لكن ال بيكورنا فيروس والذي
+
+34
+00:02:31,110 --> 00:02:36,150
+اسمها يحتوي على معلومات مهمة بيكو very small RNA
+
+35
+00:02:36,150 --> 00:02:41,050
+small RNA فيروس بيكو RNA فيروس بيكورنا فيروس
+
+36
+00:02:41,050 --> 00:02:45,730
+بتجتمل على ال انترو فيروس زي ال بوليو فيروس و
+
+37
+00:02:45,730 --> 00:02:49,210
+الكوكساكي فيروس و الايكو فيروس و الهيباطايتس a
+
+38
+00:02:49,210 --> 00:02:54,240
+فيروس لكن الهيباطايتسانسوها، ليش انسوها؟ لأننا
+
+39
+00:02:54,240 --> 00:02:57,820
+بدنا ناخدها في مجموعة خاصة، ماحنا برضه أول chapter
+
+40
+00:02:57,820 --> 00:03:01,780
+درسناها كان ال DNA في ال clinical biology كان ال
+
+41
+00:03:01,780 --> 00:03:05,100
+DNA virus وكان أخر واحدة منهم اللي هي Hepatitis B
+
+42
+00:03:05,100 --> 00:03:08,040
+وقلنالكوا هذه بدنا ننقلها ل chapter خاص اسمه
+
+43
+00:03:08,040 --> 00:03:13,870
+Hepatitis virusesبعد الانتروفيروس فيانا الراينو
+
+44
+00:03:13,870 --> 00:03:18,750
+فيروس اللي هو الشهير بالرشح المسئول عن أوراق مواحد
+
+45
+00:03:18,750 --> 00:03:22,350
+مسبب لمرض الرشح اللي احنا عرفنا انه فيه أكتر من
+
+46
+00:03:22,350 --> 00:03:27,930
+بلوس بسببه إذن ب كورنا فيروس كاليسي فيروس وريو
+
+47
+00:03:27,930 --> 00:03:32,420
+فيروسنبدأ ان شاء الله بال بيكورنا viruses وهي كما
+
+48
+00:03:32,420 --> 00:03:36,740
+ذكرنا small حوالي عشرين و تلاتين نانومتر تحتوي على
+
+49
+00:03:36,740 --> 00:03:41,280
+ايكوزاهيدرال نكليوكابسيد single-stranded RNA جينوم
+
+50
+00:03:41,280 --> 00:03:44,200
+بوستف بولارتي وبتالي الجينم تبقى احد بيكون يعيش في
+
+51
+00:03:44,200 --> 00:03:49,700
+هذه الحالة infectious احد ما يتميز به هذا الجينوم
+
+52
+00:03:49,700 --> 00:03:53,900
+مختلف عن باقي الجينوم اللي في الدنيا كلاتها انه
+
+53
+00:03:53,900 --> 00:04:01,960
+على ال five prime لل بوستف سينس RNAيوجد protein مش
+
+54
+00:04:01,960 --> 00:04:05,400
+موجود في ال others هذا ال protein serves as a
+
+55
+00:04:05,400 --> 00:04:09,260
+primer يعني بيشتغل كprimer لل transcription لهذا
+
+56
+00:04:09,260 --> 00:04:15,440
+ال gene وبالتالي يعني هو صحيح ببسط في sense RNA
+
+57
+00:04:15,440 --> 00:04:19,340
+لكن محتوى على كده مرة على protein إضافي يساعده على
+
+58
+00:04:19,340 --> 00:04:24,380
+ان يعمل كprimer لل transcription ال بيكورنا فياسبت
+
+59
+00:04:24,380 --> 00:04:28,660
+كثر في الcytoplasm دلوقتي على الخلاياو بيشمل اتنين
+
+60
+00:04:28,660 --> 00:04:32,080
+مهمين جدا اللي هم ال انترو فيروس و ال رينو فيروس
+
+61
+00:04:32,080 --> 00:04:35,700
+طبعا ال انترو فيروس جمع يعني ما يبقى حاجة انه في
+
+62
+00:04:35,700 --> 00:04:41,760
+انه مجموعة ايضا among the major enterovirus are
+
+63
+00:04:41,760 --> 00:04:48,100
+poliovirus, kokusaki virus, ecovirus and hepatitis
+
+64
+00:04:48,100 --> 00:04:51,820
+A virus و ذكرنا هذا الكلام سابقا اتذكروا يالله
+
+65
+00:04:51,820 --> 00:04:55,380
+يرضى عليكم اتنين و تلاتة وين ذكرناهم مرانا و
+
+66
+00:04:55,380 --> 00:04:58,210
+تكرارافي الاسبتك مينينجايتس في الاسبتك مينينجايتس
+
+67
+00:04:58,210 --> 00:05:01,890
+في الاسبتك مينينجايتس along with mumps they are
+
+68
+00:05:01,890 --> 00:05:05,910
+the most common cause of aseptic meningitis اذا
+
+69
+00:05:05,910 --> 00:05:10,150
+ايكو والكوكساكي على الرغم من انهم انتريك فيروس الا
+
+70
+00:05:10,150 --> 00:05:14,090
+انهم بيعملوا مينينجايتس تجربة مقارنة سريعة بين
+
+71
+00:05:14,090 --> 00:05:18,750
+الانترو فيروس وبين ال رينو فيروسأين الانتيرو فيروس
+
+72
+00:05:18,750 --> 00:05:24,770
+انفكس الوامين فقط
+
+73
+00:05:24,770 --> 00:05:29,630
+الناوز والثروت طبعا حد مايعرفلش لان ال temperature
+
+74
+00:05:29,630 --> 00:05:32,710
+اللي بينمو عليها الانتيرو فيروس سبعة و تلاتين
+
+75
+00:05:32,710 --> 00:05:37,550
+بينما ال رينو فيروس بيهد جداش تلاتة و تلاتين في
+
+76
+00:05:37,550 --> 00:05:42,550
+كمان معلومة مهمة جدا اللي هي ال acidity الانتيرو
+
+77
+00:05:42,550 --> 00:05:46,050
+فيروس هم مقاومين الاسد عشان هم ممروا عبر المعدة و
+
+78
+00:05:46,050 --> 00:05:50,900
+بيصلوا لمينلكن فيروس الرشح لو مر على المعدة لانه
+
+79
+00:05:50,900 --> 00:05:54,300
+sensitive بتكسر وبالتالي لايمكن يعمل infection في
+
+80
+00:05:54,300 --> 00:05:59,220
+الأمعاء في practice في رز هنا بعض الناس بتعمله ان
+
+81
+00:05:59,220 --> 00:06:02,500
+المرشح اللي عنده رشح يعنيه بنبط لمون في أنفه
+
+82
+00:06:03,500 --> 00:06:07,660
+الليمون انت تعرفين حامض قد يكون .. قد يكون احد
+
+83
+00:06:07,660 --> 00:06:10,600
+الأسباب طبعا احنا .. احنا .. هذا ال .. ال .. ال
+
+84
+00:06:10,600 --> 00:06:13,380
+common practice was not scientifically tested يعني
+
+85
+00:06:13,380 --> 00:06:16,800
+ما .. لما تم فحصه علميا بس احنا جايبين بنفسر و
+
+86
+00:06:16,800 --> 00:06:20,240
+بنربط المعلومة بنقول انه مدان بتأثر بالحامض قد
+
+87
+00:06:20,240 --> 00:06:24,060
+يكون هذا السبب في انه الناس تشعر بتحسن عندما تبع
+
+88
+00:06:24,060 --> 00:06:30,030
+هذا الليمونالان عدم قدرته على التكاثر الا في تلات
+
+89
+00:06:30,030 --> 00:06:34,250
+تلاتين وعدم تحمل ال acid هذا الذي يفسر ان ال
+
+90
+00:06:34,250 --> 00:06:38,470
+rhinoviruses will not cause gastroenteritis فقط
+
+91
+00:06:38,470 --> 00:06:41,210
+limited to the upper respiratory tract infection
+
+92
+00:06:42,200 --> 00:06:45,560
+الجدول اللي أمامنا هذا ليس جدول للمحاضرة تبعتنا،
+
+93
+00:06:45,560 --> 00:06:50,060
+المفروض أنه جدول عام بيقول ما هي الفيروسات التي
+
+94
+00:06:50,060 --> 00:06:55,380
+تسبب Gastroenteritis، لكن دي جدول مهم لأن كل
+
+95
+00:06:55,380 --> 00:07:00,300
+الفيروسات المذكورة فيه ما عدا واحد من موضوعناأخر
+
+96
+00:07:00,300 --> 00:07:03,300
+واحد مين هو ال adenovirus؟ ال adenovirus كنا من ال
+
+97
+00:07:03,300 --> 00:07:08,740
+DNA فيروس مظبوط وهو DNA فيروس بالفعل والباقين كلهم
+
+98
+00:07:08,740 --> 00:07:12,120
+Polio, Eko, Kokusaki, Hepatitis A, Rotavirus,
+
+99
+00:07:12,480 --> 00:07:15,940
+Norovirus كل ما دولة من المجموعة اللي احنا بدرسها
+
+100
+00:07:15,940 --> 00:07:21,800
+اللي هي ال RNA، non-enveloped virusحتى ال
+
+101
+00:07:21,800 --> 00:07:26,840
+adenovirus هو DNA non-enveloped virus اطلعولي على
+
+102
+00:07:26,840 --> 00:07:32,420
+جبل كل إشي على ال antiviral therapy أخر عمود أخر
+
+103
+00:07:32,420 --> 00:07:36,840
+عمود كلهم مافيش اللي هم antiviral therapy و أنا
+
+104
+00:07:36,840 --> 00:07:42,280
+قلتلكم من بداية الفصل نحن لسنا ناجحين في إيجاد
+
+105
+00:07:42,280 --> 00:07:45,920
+antivirals زي ما ناجحين في إيجاد antibacterial
+
+106
+00:07:45,920 --> 00:07:52,420
+تمام؟طبعا اللي بيساعدنا انهم يعني انه نواسع نفسنا
+
+107
+00:07:52,420 --> 00:07:55,680
+في هذا المجال انه كثير من ال viral infection are
+
+108
+00:07:55,680 --> 00:07:59,560
+self-limited لحالة بتروح صحيح ممكن تكون صعبة و
+
+109
+00:07:59,560 --> 00:08:03,400
+ممكن تكون مؤذية لكن في الآخر self-limited معظمها
+
+110
+00:08:03,400 --> 00:08:06,860
+تراها ال vaccine availability ال poly طبعا نجم
+
+111
+00:08:06,860 --> 00:08:13,560
+نجوم ال ال الالأمراض اللي العالم بيسعى إلى التخلص
+
+112
+00:08:13,560 --> 00:08:17,000
+منها تماما وحنشوف كمان شوية ان مرضى مصحى العالمية
+
+113
+00:08:17,000 --> 00:08:20,720
+كانت حاطة هدف من أهدافها ال استراتيجية انه بحلول
+
+114
+00:08:20,720 --> 00:08:25,600
+عام 2005 عام 2005 مر من 12 سنة تمام؟ انه بحلول عام
+
+115
+00:08:25,600 --> 00:08:31,040
+2005 ان نتخلص من وباء البوليو فبالتالي ال vaccine
+
+116
+00:08:31,040 --> 00:08:35,060
+بالفعل موجود وفعال بدرجة كبيرة وخفض نسبة الحالات
+
+117
+00:08:35,060 --> 00:08:39,200
+إلى أعداد ضئيلة جدا سنة كرهة لما نتكلم عن البوليو
+
+118
+00:08:40,680 --> 00:08:44,380
+مين من الفيروسات الآن التانية له vaccine Hepatitis
+
+119
+00:08:44,380 --> 00:08:49,260
+A virus وبالفعل Hepatitis A أصبح يعني common له
+
+120
+00:08:49,260 --> 00:08:54,000
+التطعيم في كمان فيروس هم ضمن القائمة احنا حاطينه
+
+121
+00:08:54,000 --> 00:08:55,960
+هنا negative مافيش له vaccine اللي هو اللي ورا على
+
+122
+00:08:55,960 --> 00:09:01,560
+طول rotavirus الان فيه rotavirus vaccine يالا نحطه
+
+123
+00:09:01,560 --> 00:09:04,220
+post هنا وانا هعدله في ال presentation ان شاء الله
+
+124
+00:09:04,220 --> 00:09:07,830
+انه موجود له vaccineالان في سؤال ايه لي أنا بس
+
+125
+00:09:07,830 --> 00:09:12,010
+سؤال انا حاطه ال adenovirus انا حاطه negative و
+
+126
+00:09:12,010 --> 00:09:15,790
+علامات استفهام، يعني طبعا فيه له vaccine ولا مش
+
+127
+00:09:15,790 --> 00:09:20,410
+vaccine؟ على علمكم .. على علمكم .. يعني على عملتكم
+
+128
+00:09:20,410 --> 00:09:23,410
+و اللي دراستكم معاه، فيه له vaccine؟ فيه له
+
+129
+00:09:23,410 --> 00:09:27,880
+vaccine ولا مش؟ ايه له vaccine؟لكن مش للإسهال
+
+130
+00:09:27,880 --> 00:09:32,360
+للrespiratory احنا جونا فيه عنا عدد كبير اكتر من
+
+131
+00:09:32,360 --> 00:09:36,380
+اكتر من 41 42 تقريبا strain جونا من اللي هو ال
+
+132
+00:09:36,380 --> 00:09:40,500
+adenoviruses منها مجموعة بتسبب respiratory tract
+
+133
+00:09:40,500 --> 00:09:44,740
+infection وجونا خاصة في ال military recruit وعملنا
+
+134
+00:09:44,740 --> 00:09:50,290
+لهم فاكسينة تذكروا تلت حباتلكن ماعطيناهم مش لأ في
+
+135
+00:09:50,290 --> 00:09:54,010
+الدم، عطيناهم برضه gastro-intestinal بمعنى انه صار
+
+136
+00:09:54,010 --> 00:09:57,270
+فيه infection في الانتستين mild و حماتنا ضد ال
+
+137
+00:09:57,270 --> 00:10:01,230
+respiratory strength لكن ليس لدينا vaccine لحماية
+
+138
+00:10:01,230 --> 00:10:06,070
+الناس من ال gastroenteritis caused by adenovirus
+
+139
+00:10:06,070 --> 00:10:08,730
+عشان انا حاطيت negative عشان تعرفوا ان negative
+
+140
+00:10:08,730 --> 00:10:11,430
+مالوش vaccine ده ال gastroenteritis لكن ده
+
+141
+00:10:11,430 --> 00:10:14,430
+respiratory tracked فيه له vaccine و يعطى فقط
+
+142
+00:10:14,430 --> 00:10:18,770
+لمين؟ للمilitaryبالنسبة للـ Immunity العمودي
+
+143
+00:10:18,770 --> 00:10:22,930
+الثالث من الأخير، من قبل الأخير بيعطينا Hepatitis
+
+144
+00:10:22,930 --> 00:10:26,750
+A و الـ Polio lifelong immunity وهذا شيء جيد
+
+145
+00:10:26,750 --> 00:10:31,010
+بالنسبة للـ Serotype الـ Polio بنوعه من الآن أن هو
+
+146
+00:10:31,010 --> 00:10:35,050
+عبارة عن ثلاثة Serotypes وللأسف الثلاثة Serotypes
+
+147
+00:10:35,050 --> 00:10:38,210
+ولا واحد منهم بيعطي cross reactivity مع التاني
+
+148
+00:10:38,210 --> 00:10:41,950
+بمعنى إنه إذا وصيك الإنسان في واحد ممكن ينصب
+
+149
+00:10:41,950 --> 00:10:44,550
+التاني ويمكن ينصب التالت وبالتالي الفاكسينة لازم
+
+150
+00:10:44,550 --> 00:10:49,180
+يحتاج على مين؟ على الثلاثةالإيكوفيروس ماني،
+
+151
+00:10:49,180 --> 00:10:52,820
+الكوكساكي فيروس ماني، ويمكن هذا السبب إن احنا مش
+
+152
+00:10:52,820 --> 00:10:56,600
+قادرين نعمل vaccine، اللهم الروتافيروس على الرغم
+
+153
+00:10:56,600 --> 00:11:03,140
+من أنه several، إلا أنه أهميته خلت العالم يحاول
+
+154
+00:11:03,140 --> 00:11:05,900
+يعمل vaccine و بالفعل نجحه، و الآن ال vaccine
+
+155
+00:11:05,900 --> 00:11:11,040
+موجود في السوق ويعطيها للأطفالالنوروفيروس unknown
+
+156
+00:11:11,040 --> 00:11:14,900
+يعني هو جديد باكتشافه باعتباره وبالتالي ماعناش
+
+157
+00:11:14,900 --> 00:11:18,520
+معرفة كبيرة بالنسبة لأدينوفيروس احنا ذكرناها سابقا
+
+158
+00:11:18,520 --> 00:11:22,020
+انه حوالي اتنين واربعين zero types لان تعرف تلعب
+
+159
+00:11:22,020 --> 00:11:27,440
+الأمراض الأولاني polyomyelitis على رغم ان هي ايش
+
+160
+00:11:27,440 --> 00:11:30,860
+قلناها gastrointestinal infection لكن في الآخر
+
+161
+00:11:30,860 --> 00:11:34,420
+بتروح على ال nerve و بتعمل polyomyelitis او شلل
+
+162
+00:11:34,420 --> 00:11:39,710
+الأطفالاتنين و تلاتة بيعملوا meningitis هذا ال ..
+
+163
+00:11:39,710 --> 00:11:43,530
+ال .. ال very .. very common و most important يعني
+
+164
+00:11:43,530 --> 00:11:48,530
+خلّيني نقول prominent finding of the disease ال
+
+165
+00:11:48,530 --> 00:11:51,830
+hepatitis ايه؟ Hepatitis و انا قبل ما اجيكوا كان
+
+166
+00:11:51,830 --> 00:11:55,030
+احد الطلاب يسألني يقول دكتور طب مدام ال .. ال
+
+167
+00:11:55,030 --> 00:11:59,610
+hepatitis viruses واحد من ال DNA virus و واحد من
+
+168
+00:11:59,610 --> 00:12:02,450
+ال RNA و كل واحد شكل ليه احنا حاطينه في مجموعة
+
+169
+00:12:02,450 --> 00:12:10,990
+واحد؟ولماذا هناك فيروسات بتصيب الكبد ولم تحسب مع
+
+170
+00:12:10,990 --> 00:12:15,830
+الهيباطيتس فيروس؟ يبقى في انديان سؤالين ليش هم
+
+171
+00:12:15,830 --> 00:12:19,250
+مختلفين وحطيناهم في مجموعة واحدة وليش اخرين
+
+172
+00:12:19,250 --> 00:12:22,430
+بيعملوا الهيباطيتس ومحطيناهم مش مع هذه المجموعة
+
+173
+00:12:22,430 --> 00:12:29,250
+تعالوا نعرف الهيباطيتس فيروس their main and only
+
+174
+00:12:29,250 --> 00:12:34,980
+target is the liverيعني مافيش عندهم أماكن أخرى
+
+175
+00:12:34,980 --> 00:12:39,520
+يعملوها infection فقط في وين؟ في ال liver هدول
+
+176
+00:12:39,520 --> 00:12:43,300
+اللي Hepatitis و Viruses طب مش ضمنهم مع بعض، فى
+
+177
+00:12:43,300 --> 00:12:46,320
+مشكلة عندنا حقيقية لما بيكون واحد عنده Hepatitis
+
+178
+00:12:46,320 --> 00:12:50,680
+بقى بنتفرج نعرف إنها A ولا B ولا C ولا D إلا من
+
+179
+00:12:50,680 --> 00:12:55,740
+خلال فحوصات يبقى بتشابه تشابه كبير طيب معرفتنا
+
+180
+00:12:55,740 --> 00:12:59,660
+بنوع ال virus هل مهم بالنسبة لنا؟ أكيد مهم، عرفيه
+
+181
+00:12:59,660 --> 00:13:04,900
+ليش مهم؟مش بس موضوع علاج، لأ موضوع وقايا، موضوع
+
+182
+00:13:04,900 --> 00:13:11,080
+monitoring، لأن مثلا A و E هدولة جروح لحالهم،
+
+183
+00:13:11,080 --> 00:13:15,600
+بينما B و C ممكن يتحول ل chronic infection و ممكن
+
+184
+00:13:15,600 --> 00:13:18,720
+ال chronic infection هدولة يكونوا carrier و يكونوا
+
+185
+00:13:18,720 --> 00:13:23,260
+infectious للآخرينوممكن البعض منهم يتحول إلى liver
+
+186
+00:13:23,260 --> 00:13:27,800
+cancer liver cancer إذا معرفتنا بنوع ال virus مهم
+
+187
+00:13:27,800 --> 00:13:31,160
+جدا ليش ال other viruses اللي بتصيب ال liver
+
+188
+00:13:31,160 --> 00:13:36,080
+ماحطناش مع هذه المجموعة إذا كانت بتصيب أعضاء أخرى
+
+189
+00:13:36,080 --> 00:13:41,400
+مابنحطهاش مع ال hepatitis virus إذا خصصنا ال
+
+190
+00:13:41,400 --> 00:13:46,140
+hepatitis viruses إلى تلك التي فقط تصيب مين اللي
+
+191
+00:13:46,140 --> 00:13:51,190
+هو تلكبالنسبة للباجين كلهم كانوا عملوا دياري ال
+
+192
+00:13:51,190 --> 00:13:53,630
+rotavirus و ال norwalk و ال adenovirus كانوا
+
+193
+00:13:53,630 --> 00:13:57,930
+مسببين للدياري بالنسبة لل نوكليك أسد كلهم RNA معدى
+
+194
+00:13:57,930 --> 00:14:03,170
+ال adenovirus اذا الشيء المشترك بينهم انهم non
+
+195
+00:14:03,170 --> 00:14:08,050
+enveloped viruses صح؟ non enveloped virus لكن لحظة
+
+196
+00:14:08,050 --> 00:14:12,030
+كلهم تبعين كمان مرة او معروفين تبعين لمين؟ لل RNA
+
+197
+00:14:12,030 --> 00:14:14,970
+مش ل ال DNA واحد فقط من ال DNA virus
+
+198
+00:14:17,600 --> 00:14:22,440
+طب نيجي لل انترو فيروس وبالاخره ال polyovirus
+
+199
+00:14:26,850 --> 00:14:30,950
+الدزيز اللى بتسببه هذا الفيروس اسمه poliomyelitis
+
+200
+00:14:30,950 --> 00:14:35,870
+أو بالعربية شلل الأطفال او الشلل الشلل important
+
+201
+00:14:35,870 --> 00:14:40,150
+properties الفيروس بيصيب ال primates ال primates
+
+202
+00:14:40,150 --> 00:14:42,770
+اللى هم الأوليات اللى هى الأرقى الثديات اللى بيقول
+
+203
+00:14:42,770 --> 00:14:48,050
+عنها الإنسان و القرود ال apes اللى هى الغريلات و
+
+204
+00:14:48,050 --> 00:14:52,100
+القرود الأخرىطبعا هذا بيصيبهم مش بعد الحاجة ان هم
+
+205
+00:14:52,100 --> 00:14:54,280
+ال natural host، ال natural host هو فقط من
+
+206
+00:14:54,280 --> 00:14:58,060
+الإنسان، لكن ال virus قد يصيب .. يعني لو احنا
+
+207
+00:14:58,060 --> 00:15:02,790
+experimentally يمكن نصيب في هذه المخلوقاتالـ RNA
+
+208
+00:15:02,790 --> 00:15:05,490
+تبعه لأنه هناك و إنه بوصت في سنسه هو infectious
+
+209
+00:15:05,490 --> 00:15:08,490
+فيه three physiological type وهذا الكلب عرفناه من
+
+210
+00:15:08,490 --> 00:15:14,030
+الجدول based on different antigenic component على
+
+211
+00:15:14,030 --> 00:15:16,690
+الكبسيد تبعه اللي عامفش ياخدوا بالك هو envelope
+
+212
+00:15:16,690 --> 00:15:20,250
+مافيش envelope فأي antigenic تبعها تكون على
+
+213
+00:15:20,250 --> 00:15:23,410
+الكبسيد لما بيكون في envelope لما بيكون في
+
+214
+00:15:23,410 --> 00:15:26,390
+envelope بيتكلم عن ال envelope لما مايكونش في
+
+215
+00:15:26,390 --> 00:15:31,670
+envelope بيتكلم عن مين عن الكبسيد itselfزي ما
+
+216
+00:15:31,670 --> 00:15:34,670
+حكينا مافيش cross-reaction بين السترانز وبالتالي
+
+217
+00:15:34,670 --> 00:15:38,330
+الإنسان اللي بيصاب واحد بيوفرش حماية للأخرين أو
+
+218
+00:15:38,330 --> 00:15:41,250
+الأتنين الأخرين بينتقل عبر الفكال oral route
+
+219
+00:15:41,250 --> 00:15:46,170
+ودعوني أذكر هنا بنقطة أو بقضية مهمة في موضوع ال
+
+220
+00:15:46,170 --> 00:15:49,520
+transmission اللي هو الفكال oral routeطب الهدا ما
+
+221
+00:15:49,520 --> 00:15:54,640
+بنعزو انخفاض نسب الإصابة مثلا في عملاء الفيروسية
+
+222
+00:15:54,640 --> 00:15:58,080
+زي لل vaccine، مظهر؟ بنقول أن ال vaccine حسن من ..
+
+223
+00:15:58,080 --> 00:16:01,740
+هذا كلام صحيح، لكن اللي بيحسن أكتر من ال vaccine
+
+224
+00:16:01,740 --> 00:16:06,380
+هو ال improvement في ال .. و ال proper sewage
+
+225
+00:16:06,380 --> 00:16:11,380
+disposal، تخلص الأمن منين؟ من المياه العادمة،
+
+226
+00:16:11,380 --> 00:16:15,650
+المياه العادمةوبيعطيكوا بس بعض ال .. يعني اللامحات
+
+227
+00:16:15,650 --> 00:16:20,530
+عن تاريخيا في غزة النهارة، قبل عشرين سنة كنا نعمل
+
+228
+00:16:20,530 --> 00:16:23,510
+testing لعينات ال stool من بعض المناطق، بتنشأتكوا
+
+229
+00:16:23,510 --> 00:16:28,340
+المناطق، بيزعلوا صحابهافكنا نجد فيها نسب الإصابة
+
+230
+00:16:28,340 --> 00:16:32,520
+بالبرأة زي طريقة مثال زي ال Ascaris زي ال Guardia
+
+231
+00:16:32,520 --> 00:16:35,280
+و ال Amoeba و ال Mixed Infection نكون تلاقي تلاتة
+
+232
+00:16:35,280 --> 00:16:39,240
+أو اتنين مع بعض في نفس العينة كانت نسب كبيرة في
+
+233
+00:16:39,240 --> 00:16:42,680
+بعض المناطق لما جينا التلانة على المناطق هذه لجينا
+
+234
+00:16:42,680 --> 00:16:46,240
+ان الفرق بينها و بين المناطق الأخرى ان مافيش فيها
+
+235
+00:16:46,240 --> 00:16:49,640
+sewage system مافيش فيها أنظمات ضخمة جارية كانت
+
+236
+00:16:49,640 --> 00:16:53,380
+بتنده عالمين على الحفر اللي بيحفروها و يتخلصوا من
+
+237
+00:16:53,380 --> 00:16:56,520
+النفاة المنزليةوكل ما يتعبى يتصلوا في البلدية
+
+238
+00:16:56,520 --> 00:17:00,400
+يتيجي يتخلصهم من هذا ال .. طبعا الشوارع كانت غير
+
+239
+00:17:00,400 --> 00:17:03,980
+مرصوفة ايضا فكانت نسبة النفايات والمياه العادى ما
+
+240
+00:17:03,980 --> 00:17:08,220
+تصل للشوارع ففي هذه الحالة عملية الانتقال كانت
+
+241
+00:17:08,220 --> 00:17:13,370
+سهلة جدا فيها ال oral transmissionلأن لما نفس
+
+242
+00:17:13,370 --> 00:17:16,910
+المنطقة صار فيها sewage system والشوارع تباتها
+
+243
+00:17:16,910 --> 00:17:22,490
+رُصفت أصبحت هذه المنطقة أقل إصابة من مناطق أخرى
+
+244
+00:17:22,490 --> 00:17:26,590
+كانت في السابق تُعرف عليها يعني من أرقى المناطق
+
+245
+00:17:26,590 --> 00:17:30,300
+وأنضف المناطقيبقى الفارق اللي .. اللي حصل ما ..
+
+246
+00:17:30,300 --> 00:17:32,440
+ماعملنا vaccine جديد للبرزايس، مافيش vaccine
+
+247
+00:17:32,440 --> 00:17:36,460
+للبرزاية، تمام؟ كل اللي صار انه بس حسننا ال
+
+248
+00:17:36,460 --> 00:17:40,200
+storage disposal و غطينا الشوارع، غطينا الشوارع من
+
+249
+00:17:40,200 --> 00:17:43,540
+ال .. من ال .. من الأطفال، ما بتبولوش، بتبرزوش في
+
+250
+00:17:43,540 --> 00:17:46,960
+هذه المناطق وبتالي مافيهش transmission، والمياه
+
+251
+00:17:46,960 --> 00:17:51,570
+العادية ما بطلت تصل هذه الشوارعإذا الفيكل oral
+
+252
+00:17:51,570 --> 00:17:56,170
+transmission حله الرئيسي هو proper sewage
+
+253
+00:17:56,170 --> 00:18:01,670
+treatment أو disposal and treatment و public
+
+254
+00:18:01,670 --> 00:18:05,770
+health يعني خلّيني نقول measures sanitation نضافة
+
+255
+00:18:05,770 --> 00:18:10,290
+عامة و نضافة شخصية هدول التلات حلول حتى في غياب
+
+256
+00:18:10,290 --> 00:18:13,250
+الفاكسين قد يساعدوا في خفض اللي هو الإصابة
+
+257
+00:18:13,250 --> 00:18:16,430
+بالأمراض المنتقلة عن طريق الفيكل oral route والذي
+
+258
+00:18:16,430 --> 00:18:18,330
+يعتبر ال polio أحدها
+
+259
+00:18:27,840 --> 00:18:31,100
+النظافة العامة متمثلة في الأشياء اللي ذكرناها
+
+260
+00:18:31,100 --> 00:18:35,400
+بتساعد كتير it can replicate in the oropharynx and
+
+261
+00:18:35,400 --> 00:18:37,960
+intestinal tract human are the only natural host
+
+262
+00:18:37,960 --> 00:18:42,900
+successful vaccines has eradicated the disease
+
+263
+00:18:42,900 --> 00:18:47,550
+from the united states andindeed from the entire
+
+264
+00:18:47,550 --> 00:18:52,310
+western hemisphere نصف الكورة العرضية الغربي تم
+
+265
+00:18:52,310 --> 00:18:57,710
+تحلص من هذا الفيروسالحياة النادية اللتي حدثت في
+
+266
+00:18:57,710 --> 00:19:03,730
+الولايات المتحدة حدثت من أمثلة كالتالي واحد وناس
+
+267
+00:19:03,730 --> 00:19:08,490
+تعرضوا ل ال virus revertant of the attenuated
+
+268
+00:19:08,490 --> 00:19:13,630
+virus كلكوا تذكروا الأيوب أو مش الأيوب المخاوف
+
+269
+00:19:13,630 --> 00:19:18,910
+اللتي تحدثنا عنها من ال live attenuated اللي هو ال
+
+270
+00:19:18,910 --> 00:19:24,010
+live vaccineأحد هذه المخاوف انه يتحول من
+
+271
+00:19:24,010 --> 00:19:27,570
+attenuated إلى ال wild type او ال active type
+
+272
+00:19:27,570 --> 00:19:30,950
+حالات حدثت في الولايات المتحدة من تعرض ناس ل
+
+273
+00:19:30,950 --> 00:19:37,010
+revertant رقم اتنين و ناس مش مطعمين ذهبوا الى
+
+274
+00:19:37,010 --> 00:19:40,630
+اماكن موبوءة و اتعرضوا لل wild type ال wild type
+
+275
+00:19:40,630 --> 00:19:44,870
+هو ال بيروس مش المضعف ال wild يعني بري اللي هو
+
+276
+00:19:44,870 --> 00:19:48,130
+الحقيقي ال .. ال .. ال attenuated هو اللي استقبلنا
+
+277
+00:19:48,130 --> 00:19:52,960
+في مين؟في ال vaccine فهو مش مطعم طفل مثلا ولد في
+
+278
+00:19:52,960 --> 00:19:56,600
+الولايات المتحدة ماتطعمش و سافر اهله على منطقة
+
+279
+00:19:56,600 --> 00:19:59,640
+موبوءة مثل باكستان او افغانستان لانه لان هم
+
+280
+00:19:59,640 --> 00:20:03,040
+الدولتان الواحدتان اللي عملوا تقرير السنة الماضية
+
+281
+00:20:03,040 --> 00:20:07,400
+انه ما زال فيهم polio myelitis ففي هذه الحالة ممكن
+
+282
+00:20:07,400 --> 00:20:11,920
+ينتقل اليهم اللي هو الفيروسلما .. قبل ما بيستخدم
+
+283
+00:20:11,920 --> 00:20:18,540
+ال vaccine كانت الاوبيه تحدث في الصيف و في الخريف
+
+284
+00:20:18,540 --> 00:20:23,650
+ال fall معناها خريف مخطوط فيها خريفكما ذكرتلكم
+
+285
+00:20:23,650 --> 00:20:26,870
+المنظمة الصحية العالمية حاولت انها تحط هدف ان في
+
+286
+00:20:26,870 --> 00:20:31,710
+ال 2005 بحيث عام 2005 انها تنهي من اللي هو ال
+
+287
+00:20:31,710 --> 00:20:36,910
+polio myelitis لكن للأسف في 2007 كان هناك 16 دولة
+
+288
+00:20:36,910 --> 00:20:42,350
+ما زال فيها polio الا ان نسبة الإصابات انخفضت يعني
+
+289
+00:20:42,350 --> 00:20:45,630
+الجهود اللي بودرت ما راحتها بقى صحيح ما زال فيه
+
+290
+00:20:45,630 --> 00:20:50,130
+polio لكن الناس بقى اتطلعوا في العام 1988 و هذا ال
+
+291
+00:20:50,130 --> 00:20:53,900
+vaccine كان موجود يعنيكان فيه حوالي أكتر من ربع
+
+292
+00:20:53,900 --> 00:20:58,520
+مليون حالة سنوية worldwide طيب في العام الفين و
+
+293
+00:20:58,520 --> 00:21:02,220
+خمسة كان العدد أقل من جداش من الفين في العام الفين
+
+294
+00:21:02,220 --> 00:21:05,040
+و ستة عشر اللي هو العام المنصرم كان العدد أقل من
+
+295
+00:21:05,040 --> 00:21:07,760
+مائة أظن ستة و تمانين أو ستة و ستين لا أذكر الرقم
+
+296
+00:21:07,760 --> 00:21:12,180
+لكن أقل بالتأكيد أقل من مائة حالة و من دولتان فقط
+
+297
+00:21:12,180 --> 00:21:16,380
+هنا جدش كانوا ستة عشر دولة الآن صاروا كدهاش دولتين
+
+298
+00:21:16,620 --> 00:21:20,120
+ومتوقع في الأعوام القادمة إذا بقي ال rhythm على ما
+
+299
+00:21:20,120 --> 00:21:25,580
+هو في نشاطنا في التطييم والتوية والمراقبة ان
+
+300
+00:21:25,580 --> 00:21:31,660
+بالفعل انه بحلول عام 2020 ان نكون خلصنا من ال poll
+
+301
+00:21:31,660 --> 00:21:36,920
+اذا لم نستطع نتخلص من ال poll، نتخلص من مين احنا
+
+302
+00:21:36,920 --> 00:21:38,860
+فقط؟ من ال small box
+
+303
+00:21:41,280 --> 00:21:44,720
+بعد ما بتكاتر الفيروس بنات في ال .. ال .. ال .. ال
+
+304
+00:21:44,720 --> 00:21:44,860
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+305
+00:21:44,860 --> 00:21:45,560
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+306
+00:21:45,560 --> 00:21:45,860
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+307
+00:21:45,860 --> 00:21:48,540
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+308
+00:21:48,540 --> 00:21:48,540
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+309
+00:21:48,540 --> 00:21:53,280
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+310
+00:21:53,280 --> 00:21:58,820
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+311
+00:21:58,820 --> 00:21:58,820
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+312
+00:21:58,820 --> 00:21:59,380
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+313
+00:21:59,380 --> 00:21:59,380
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+314
+00:21:59,380 --> 00:21:59,380
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+315
+00:21:59,380 --> 00:22:02,560
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+316
+00:22:10,520 --> 00:22:13,360
+بسموه innervating يعني بي بي بي بي بي بي بي بي بي
+
+317
+00:22:13,360 --> 00:22:13,500
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+318
+00:22:13,500 --> 00:22:13,620
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+319
+00:22:13,620 --> 00:22:19,560
+بي بي بي بي بي بي بي بي بي بي بي بي
+
+320
+00:22:19,560 --> 00:22:23,080
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+321
+00:22:23,080 --> 00:22:26,200
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+322
+00:22:26,200 --> 00:22:29,260
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+323
+00:22:29,260 --> 00:22:36,540
+بي ب
+
+324
+00:22:39,480 --> 00:22:45,260
+من القرن الماضي كانت شائع ان نشوف اطفال من جيلنا
+
+325
+00:22:45,260 --> 00:22:50,100
+او اكبر مننا تمام انهم يكونوا عندهم شلل او بيعانوا
+
+326
+00:22:50,100 --> 00:22:56,650
+من شلل في احد الأطراف من ناتج عنأنا حتى لما بعرف
+
+327
+00:22:56,650 --> 00:23:00,030
+بعض الأشخاص يعني من السن تبقى يعني أكبر شوية
+
+328
+00:23:00,030 --> 00:23:05,690
+مصابين بهذا المرض الخبيث والذي يعني أنا كتبت عنه
+
+329
+00:23:05,690 --> 00:23:08,990
+مقالة من ضمن المقالات اللي كنت أكتبها في سلسلة
+
+330
+00:23:08,990 --> 00:23:12,350
+اسمها ميكروبات صنعت لها مكانا في التاريخ فهذا
+
+331
+00:23:12,350 --> 00:23:16,450
+الميكروب من الميكروبات اللي كان يثير القشعريرة في
+
+332
+00:23:16,450 --> 00:23:20,710
+.. عندما يسمع الإنسان باسمه لإنه على الرغم من إنه
+
+333
+00:23:21,350 --> 00:23:26,210
+نسبة إحداثه لشلل الأطفال في الناس المصابين قليلة
+
+334
+00:23:26,210 --> 00:23:31,450
+جدا إلا إنها للنسبة لانه debilitating شلل مش حاجة
+
+335
+00:23:31,450 --> 00:23:37,770
+يعني فقد مثلا سماع في أذن أو كده لأ الآن هو مشلول
+
+336
+00:23:37,770 --> 00:23:42,710
+هذا يعني complicated خطيرة على الإنسان رقم اتنين
+
+337
+00:23:42,710 --> 00:23:48,000
+فيه كمان نسبة وفيات لاباسة بهالأنه بيدمر ال brain
+
+338
+00:23:48,000 --> 00:23:53,420
+stem و ال brain stem مسئولة عن بعض الحركات
+
+339
+00:23:53,420 --> 00:23:59,540
+اللايرادية زي التنفس فإذا ضربت ال brain stem بيضرب
+
+340
+00:23:59,540 --> 00:24:03,740
+التنفس وبتالي بيموت المريض من respiratory failure
+
+341
+00:24:05,760 --> 00:24:09,760
+الـ Paralysis بينتج عن هذا المرأة اللي ممكن نادى
+
+342
+00:24:09,760 --> 00:24:11,800
+الجملة الأخيرة، death of these cells result in
+
+343
+00:24:11,800 --> 00:24:14,820
+paralysis of the muscle innervated by those
+
+344
+00:24:14,820 --> 00:24:17,540
+neurons وبالتالي بيصير لنا شرع اللي جونا عنه
+
+345
+00:24:17,540 --> 00:24:23,470
+الإرتخاءالـ Plasma Stem زي ما حكينا بيدّي لغير الـ
+
+346
+00:24:23,470 --> 00:24:26,610
+Poliomyelitis بالاضافة لـ Respiratory Paralysis
+
+347
+00:24:26,610 --> 00:24:29,930
+اللي هو الشلل في عضوات اللي هو الجهاز التنفسي
+
+348
+00:24:29,930 --> 00:24:34,470
+المناعة والاستجابة المناعية لهذا ال .. ال بيروس
+
+349
+00:24:34,470 --> 00:24:39,670
+غالبا تتشكل من شغلتين أساسيتين اللي هم Intestinal
+
+350
+00:24:39,670 --> 00:24:43,710
+IgA وهذا مهم جدا للـ Intestinal IgA بالاضافة إلى
+
+351
+00:24:43,710 --> 00:24:50,810
+Humoral اللي هو الـ IgGهذه المناعة تعطي lifelong
+
+352
+00:24:50,810 --> 00:24:54,530
+immunity وهي specific جنة للهستريني اللي بسبب
+
+353
+00:24:54,530 --> 00:25:00,230
+المرض الان تعالوا نطلع المرض ايه أشكاله في الإنسان
+
+354
+00:25:00,230 --> 00:25:06,110
+هو polyomyelitis لكن اطلعوا مقسم إلى أربع أصناف
+
+355
+00:25:07,210 --> 00:25:10,830
+تسعة وتسعين بالمائة من الصنف الأول ايش هو
+
+356
+00:25:10,830 --> 00:25:13,670
+inapparent يعني تسعة وتسعين بالمائة من الناس اللي
+
+357
+00:25:13,670 --> 00:25:17,810
+بينصفوا ال polio لا يفر عليهم أي أعراض ال واحد في
+
+358
+00:25:17,810 --> 00:25:21,730
+المائة موزة على مين؟ على abortive وكلمة abortive
+
+359
+00:25:21,730 --> 00:25:26,910
+تعني mild form of the disease ايش mild form؟ شكل
+
+360
+00:25:26,910 --> 00:25:32,660
+بسيط من المرضالرقم تلاتي الـ Non-paralytic في عراب
+
+361
+00:25:32,660 --> 00:25:37,180
+و خاصة حملة و فيه ألم لكن الـ Non-paralytic لا
+
+362
+00:25:37,180 --> 00:25:42,560
+تؤدي إلى شلل الرابعة وهي الأقل اللي هي Paralytic
+
+363
+00:25:42,560 --> 00:25:46,620
+Poliomyelitis إذا Inapparent, abortive, Non
+
+364
+00:25:46,620 --> 00:25:50,740
+-paralytic and Paralytic Poliomyelitis مين ال most
+
+365
+00:25:50,740 --> 00:25:55,800
+common؟الأولى Asymptomatic infection is quite
+
+366
+00:25:55,800 --> 00:25:59,700
+common. Roughly only one percent of infections are
+
+367
+00:25:59,700 --> 00:26:03,860
+clinically apparent يبقى ال clinically apparent هم
+
+368
+00:26:03,860 --> 00:26:08,240
+التلاتة الباجين يبقى كل ال ال ال واحد في المية
+
+369
+00:26:08,240 --> 00:26:11,560
+بشكل التلاتة لسه في ياندي اللي هم ال abortive اللي
+
+370
+00:26:11,560 --> 00:26:14,800
+هي ال mild form و ال non paralytic و الأخيرة اللي
+
+371
+00:26:14,800 --> 00:26:18,940
+هي ال paralytic poliomyelitisالـ incubation period
+
+372
+00:26:18,940 --> 00:26:23,860
+من عشرة إلى أربعة عشر يوم الـ most common form هو
+
+373
+00:26:23,860 --> 00:26:27,760
+الـ abortive poliomyelitis which is a mild febrile
+
+374
+00:26:27,760 --> 00:26:31,100
+كلمة febrile يعني فيه سخونة في حرارة illness
+
+375
+00:26:31,100 --> 00:26:34,680
+characterized by headache, sore throat, nausea and
+
+376
+00:26:34,680 --> 00:26:41,500
+vomiting معظم المرضى بيشوفوا تلقائي بدون حتى تدخل
+
+377
+00:26:41,500 --> 00:26:46,740
+لأ supportive treatment ولا غيره بيشوفوا تلقائيالـ
+
+378
+00:26:46,740 --> 00:26:51,540
+Non-paralytic poliomyelitis manifests as aseptic
+
+379
+00:26:51,540 --> 00:26:55,220
+meningitis، إذا بدكوا تلاحظوا الآن إنه صار عندنا
+
+380
+00:26:55,220 --> 00:27:00,200
+أربعة meningitis اللي أنتم دراستهم، هدهم كمان مرة
+
+381
+00:27:00,200 --> 00:27:06,480
+الأساسيات مامس، ايكوفيروس، كوكساكي فيروس ويعني هنا
+
+382
+00:27:06,480 --> 00:27:10,220
+اللي هو ال poliomyelitis virus
+
+383
+00:27:13,090 --> 00:27:15,910
+استفنك اللي طلع على الستفنك انتوا عارفين هي اصلا
+
+384
+00:27:15,910 --> 00:27:20,210
+عرب من عرب من ال meningitis الستفنك اللي هي الرقبة
+
+385
+00:27:20,210 --> 00:27:25,230
+المتصلبة رقبة المتصلبة برضه this infection resolve
+
+386
+00:27:25,230 --> 00:27:29,750
+spontaneously المشكلة اللي هتميناها الآن في الرابع
+
+387
+00:27:29,750 --> 00:27:33,690
+اللي هي ال paralytic poliomyelitis which causes
+
+388
+00:27:33,690 --> 00:27:38,600
+flaccid paralysis is the prominent findingكمان ال
+
+389
+00:27:38,600 --> 00:27:42,360
+brain stem involvement كان ممكن يؤدي إلى جنة اللي
+
+390
+00:27:42,360 --> 00:27:47,540
+هو الفشل في عملية التنفس وهذا مهدد لحياة الإنسان
+
+391
+00:27:47,540 --> 00:27:51,980
+في الزمن اللي كان البوليو منتشر اضطروا يخترعوا
+
+392
+00:27:51,980 --> 00:27:55,780
+كابسولات حديديعني يحطوا فيها المريض عشان يشكلوا
+
+393
+00:27:55,780 --> 00:28:01,740
+فيها ضغط يعني جهاز كهربائي يضغط صدر المريض فيخرج
+
+394
+00:28:01,740 --> 00:28:07,160
+الهواء ثم يعني يفرج الضغط فيضطر المريض ياخد الهواء
+
+395
+00:28:07,160 --> 00:28:10,520
+يعني وكانوا تنفس صناعي تنفس صناعي اليوم الأجزة
+
+396
+00:28:10,520 --> 00:28:14,740
+التنفس الصناعي أصبحت يعني في المتناول اليد مش زي
+
+397
+00:28:14,740 --> 00:28:19,570
+التعقيدات الساجقة يعني صارت أفضل من دي قبلطبعا هذا
+
+398
+00:28:19,570 --> 00:28:24,350
+الجهاز كان يبقى المريض فيه ممكن سنة سنتين و في
+
+399
+00:28:24,350 --> 00:28:29,810
+غالب الأمر يموت فكانوا يعني محاولة
+
+400
+00:28:29,810 --> 00:28:34,030
+من قبل الأطباء او الأهل انهم يعني يبقوا مريضهم
+
+401
+00:28:34,030 --> 00:28:38,710
+طبعا و هناك ايضا معانا شديدة لانه في انقباضات
+
+402
+00:28:38,710 --> 00:28:42,570
+asbestic painful asbestic
+
+403
+00:28:45,160 --> 00:28:47,800
+painful muscle spasm زي ما حكينا هنا painful
+
+404
+00:28:47,800 --> 00:28:52,100
+muscle spasm also occur وزي ما حكينا لكوا ال motor
+
+405
+00:28:52,100 --> 00:28:56,180
+nerve damage بيكون permanent في أصلا عندنا nerve
+
+406
+00:28:56,180 --> 00:28:59,900
+damage مش permanent كل ال nerve damage بيكون
+
+407
+00:28:59,900 --> 00:29:04,100
+permanent لكن بيقولنا انه بعد ما بيشفى المريض إذا
+
+408
+00:29:04,100 --> 00:29:08,380
+شفيا شفيا المريض وصار عنده شلل في الأول بيكون
+
+409
+00:29:08,380 --> 00:29:14,320
+الحركة ضعيفة خالصلكن بيصير في بعض التحسن في الحركة
+
+410
+00:29:14,320 --> 00:29:19,260
+لإنه يبدو إن الخلايا السليمة اللي موجودة بتاخد دور
+
+411
+00:29:19,260 --> 00:29:23,900
+الخلايا لكن لا يعود اللي هو المريض كما كان من
+
+412
+00:29:23,900 --> 00:29:29,340
+دقيقة قبل، في مصطلحين لازم نعرفهمللتعبير عن المدى
+
+413
+00:29:29,340 --> 00:29:33,100
+الأعضاء اللى صارت involved في الالتهاب مثلا لما
+
+414
+00:29:33,100 --> 00:29:36,700
+بنقول meninges بنقول meningitis ولا لأ لكن لو كان
+
+415
+00:29:36,700 --> 00:29:41,440
+meninges و brain برانكما بنقول meningoencephalitis
+
+416
+00:29:41,440 --> 00:29:43,780
+لما يكون التنين مع بعض involved يعني صار فيهم
+
+417
+00:29:43,780 --> 00:29:48,060
+inflammation meningoencephalitisإذا الـ spinal
+
+418
+00:29:48,060 --> 00:29:50,960
+cord كمان مصاب، إيش بنقول؟
+
+419
+00:29:50,960 --> 00:29:54,520
+meningomyeloencephalitis، ولا حاجة، مافيش يعني
+
+420
+00:29:54,520 --> 00:29:59,200
+نضيف مقاطع، بس meningomyeloencephalitis،
+
+421
+00:29:59,200 --> 00:30:04,930
+is often used كمصطلحالـ lab diagnosis لهذا الفيروس
+
+422
+00:30:04,930 --> 00:30:10,010
+يتم عبر عزل الفيروس أو من خلال ارتفاع في تركيز الـ
+
+423
+00:30:10,010 --> 00:30:14,110
+antibody-titer اللي بنعرفه دائما الفيروس ممكن يعزل
+
+424
+00:30:14,110 --> 00:30:18,150
+من الـ throat من الستول و من ال spinal fluid من
+
+425
+00:30:18,150 --> 00:30:23,800
+خلال زرع هذه العينات إلى cell culturesالفيروس
+
+426
+00:30:23,800 --> 00:30:29,400
+بيسبب الـcytopathic effect وممكن نتعرف على الفيروس
+
+427
+00:30:29,400 --> 00:30:33,700
+من خلال الـneutralization للـcytopathic effect
+
+428
+00:30:33,700 --> 00:30:37,720
+with specific antibodies يعني عندي antibody تلاتة
+
+429
+00:30:37,720 --> 00:30:41,580
+للواحد والاتنين وتلاتة اللي هم تلاتة strains الآن
+
+430
+00:30:41,580 --> 00:30:44,320
+الفيروس أنا منميه عامل الـcytopathic effect هذا
+
+431
+00:30:44,320 --> 00:30:47,030
+الـcytopathic effect يمكن يكون لأخر الفيروسأكيد
+
+432
+00:30:47,030 --> 00:30:51,250
+بدي أعرف إنه للـ poliovirus بروح بحط عليه أول حاجة
+
+433
+00:30:51,250 --> 00:30:57,030
+التلات antibodies إذا التلات antibodies منعوا ال
+
+434
+00:30:57,030 --> 00:31:01,770
+virus يبقى هو poliovirus إذا بدي أعرف أنه سلالة
+
+435
+00:31:01,770 --> 00:31:05,440
+منهمبأفحصه على ثلاثة cell cultures وبحط على ال
+
+436
+00:31:05,440 --> 00:31:09,020
+cell culture الأولى Antibody X Antibody Y Antibody
+
+437
+00:31:09,020 --> 00:31:13,640
+Z وبشوف وين مانع عشان أعرف بالضبط إيش نوع السلالة
+
+438
+00:31:13,640 --> 00:31:16,820
+يبقى بنجر أتعرف على ال virus من خلال ال inhibition
+
+439
+00:31:16,820 --> 00:31:23,160
+لل cytopathic effect with specific antibodiesطبعا
+
+440
+00:31:23,160 --> 00:31:26,080
+specific antisera نفس المعنى أه، antisera أو
+
+441
+00:31:26,080 --> 00:31:28,460
+antibody نفس المعنى treatment there is no
+
+442
+00:31:28,460 --> 00:31:32,020
+antiviral therapy treatment is limited to
+
+443
+00:31:32,020 --> 00:31:35,580
+symptomatic relief and respiratory support زي ما
+
+444
+00:31:35,580 --> 00:31:39,420
+حكينا اللي هي الفحال فشل اللي هو الجهاز التنفسي if
+
+445
+00:31:39,420 --> 00:31:44,200
+neededفيزيو ثيرابي اللي هو العلاج الطبيعي for the
+
+446
+00:31:44,200 --> 00:31:47,300
+affected muscles is important بعد الشفاء بيتم
+
+447
+00:31:47,300 --> 00:31:51,120
+عملية اللي هو rehabilitation اللي هي اعادة تأهيل
+
+448
+00:31:51,120 --> 00:31:57,280
+للاطفال بيحسنه كده مرة بيرجعش normal لكن بيحسنه من
+
+449
+00:31:57,280 --> 00:31:59,680
+الأداء الحركي لهذه العضلة
+
+450
+00:32:02,580 --> 00:32:07,200
+البرفنشن بالاساس زي ما ذكرتلكوا انا اعتبر على ال
+
+451
+00:32:07,200 --> 00:32:10,000
+vaccine لكن ذكرتلكوا ملاحظة على ملاحظة اللي هي ال
+
+452
+00:32:10,000 --> 00:32:14,340
+sewage disposal هذه عامة جدا هناك نوعين من ال
+
+453
+00:32:14,340 --> 00:32:18,120
+vaccine واحد اسمه Salk واحد اسمه Sabine و هدولة
+
+454
+00:32:18,120 --> 00:32:21,720
+Sabine و Salk علماء هم اللي طوروا فلو نقول Salk
+
+455
+00:32:21,720 --> 00:32:25,320
+vaccine و Sabine vaccineهدولة اعتقد .. اعتقد ..
+
+456
+00:32:25,320 --> 00:32:27,640
+والله لأ انا مش فاكر .. مش متأكد انهم اخدوا جائزة
+
+457
+00:32:27,640 --> 00:32:31,580
+نوبل برضه في الطب الاكتشاف هم هدولة ال .. ايه؟
+
+458
+00:32:31,580 --> 00:32:36,020
+اللي هم ال .. ال .. ال vaccines لإنه كمرة ال virus
+
+459
+00:32:36,020 --> 00:32:40,100
+خطير قاتل له consequences سيئة ليها ال
+
+460
+00:32:40,100 --> 00:32:44,880
+polymyelitis وبتالي ان نلاقي حد يعطينا حل له هذا
+
+461
+00:32:44,880 --> 00:32:51,460
+شيء مميزIPV-OPV هو Intramuscular .. عفوا ..
+
+462
+00:32:51,460 --> 00:32:56,320
+Inactivated Polio Vaccine و Oral Vaccine اللي هو
+
+463
+00:32:56,320 --> 00:33:06,020
+OPV، إذا IPV و OPV، اتذكروا Killed Salkسالك قتل
+
+464
+00:33:06,020 --> 00:33:15,680
+صالك و سابين قتل
+
+465
+00:33:15,680 --> 00:33:21,860
+صالك
+
+466
+00:33:22,720 --> 00:33:28,300
+both vaccine induces humoral antibodies شوفت ان ال
+
+467
+00:33:28,300 --> 00:33:33,300
+immunity لهذا الفيروس مرتبط بشكل كبير بال IGA و
+
+468
+00:33:33,300 --> 00:33:38,240
+IGG يعني ماقولناش كتير عن مين عن ال cell mediated
+
+469
+00:33:38,240 --> 00:33:44,700
+immunity أكدنا على ال IGA و IGGwhy؟ which
+
+470
+00:33:44,700 --> 00:33:48,240
+neutralizes virus entering the blood and hence
+
+471
+00:33:48,240 --> 00:33:51,580
+prevents central nervous system infection أنا أصلا
+
+472
+00:33:51,580 --> 00:33:56,040
+خايف على أن الفيروس يصل وين يصل اللي هو ال central
+
+473
+00:33:56,040 --> 00:33:59,440
+nervous system فإذا اتكون antibody جوا الدم و
+
+474
+00:33:59,440 --> 00:34:02,680
+الفيروس جزء من انتقال ال central nervous system
+
+475
+00:34:02,680 --> 00:34:05,560
+لازم يمر عبر مين؟ عبر الدم فهذا بيعمله ال
+
+476
+00:34:05,560 --> 00:34:09,240
+neutralization فالدور الكبير لهذا الفيروس معتمد
+
+477
+00:34:09,240 --> 00:34:12,870
+على ال immunoleverboth the killed and live
+
+478
+00:34:12,870 --> 00:34:16,330
+vaccines contain all three zero types يعني هذا
+
+479
+00:34:16,330 --> 00:34:22,630
+سواء كان killed او live و بالمناسبة ما ذكرناه عن
+
+480
+00:34:22,630 --> 00:34:31,130
+ال advantage و disadvantage لاتنين موجودين طيب لان
+
+481
+00:34:31,130 --> 00:34:36,050
+بدنا نعمل مقارنة بين بين سالك killed او بين سبين
+
+482
+00:34:36,050 --> 00:34:39,590
+اللي هو liveprevent disease كيلهومه نعم بيعمل
+
+483
+00:34:39,590 --> 00:34:43,430
+prevention لل disease interrupt transmission لحظه
+
+484
+00:34:43,430 --> 00:34:48,110
+ال killed لأ بينما ال live نعم بيعمل interruption
+
+485
+00:34:48,110 --> 00:34:52,550
+لل transmission بينتقلش من الإنسان إلى إنسان يعني
+
+486
+00:34:52,550 --> 00:34:57,290
+بحميني أنا تمام و الفيروس ما هو أنا قلتلكم مرة مش
+
+487
+00:34:57,290 --> 00:35:01,170
+مش في ال intestinal tract بيصير تكاثر و بيصير له
+
+488
+00:35:01,170 --> 00:35:08,040
+excretion تمامليش ماعملش interruption؟ لأنه أصلا
+
+489
+00:35:08,040 --> 00:35:14,340
+ماقداش induction ل IGA أما هذا عمل فقط لمين؟ ل IG
+
+490
+00:35:14,340 --> 00:35:20,880
+.. هذا بتلاحظوا Induced Humoral IGG كلمة نعم بينما
+
+491
+00:35:20,880 --> 00:35:25,980
+ال IGA فقط مين؟ ال live vaccine afford secondary
+
+492
+00:35:25,980 --> 00:35:29,080
+protection by spread to others؟ No Yes بحاجة كده
+
+493
+00:35:29,080 --> 00:35:32,860
+برضه بنفس المعنى الترانزميشنInterfere with the
+
+494
+00:35:32,860 --> 00:35:35,100
+replication of virulent strains in the gut؟ No
+
+495
+00:35:35,100 --> 00:35:40,920
+لأنه ماعندوش كمان مرة IGA Yes إذا الان كل هذه
+
+496
+00:35:40,920 --> 00:35:44,700
+المزايا في صالح مين قلناها؟ في صالح ال life الان
+
+497
+00:35:44,700 --> 00:35:48,280
+Revert to virulence أكيد لأنه أنا ميت بينما هذا
+
+498
+00:35:48,280 --> 00:35:53,640
+yes لكن بنجو سين راري طبعا كلمة rarely هي إشارة
+
+499
+00:35:53,640 --> 00:35:57,480
+إلى الإحتمالية يعني احنا لنا سنوات نتكلم عن ال
+
+500
+00:35:57,480 --> 00:36:04,130
+vaccine مناسب او مناسبتين حدثوبالتالي كلمة Rebly
+
+501
+00:36:04,130 --> 00:36:08,470
+هي فقط إشارة للناس إن دلوقتي يا مصنعين، دلوقتي يا
+
+502
+00:36:08,470 --> 00:36:12,310
+مطعمين، بتكونوا تراقبوا إنتوا كمان ال vaccines
+
+503
+00:36:12,310 --> 00:36:17,110
+اللي بتصنعوه و اللي بتاعته بتكونوا تراقبوا هذا ال
+
+504
+00:36:17,110 --> 00:36:17,730
+vaccine
+
+505
+00:36:21,580 --> 00:36:24,440
+with other enterovirus may impair immunization،
+
+506
+00:36:24,440 --> 00:36:30,120
+إيش معنى impair؟ Imper يعني بيخرّب، تمام؟ هل لو
+
+507
+00:36:30,120 --> 00:36:33,540
+صار co-infection مع ال vaccine، أنا أخدت ال
+
+508
+00:36:33,540 --> 00:36:36,680
+vaccine و صار عندي انترك فيروس infection، هل بيعوق
+
+509
+00:36:36,680 --> 00:36:42,120
+أو بيفشل ال vaccination، بقولنا في الكل لأ بيعوجش،
+
+510
+00:36:42,120 --> 00:36:46,480
+ليش؟ أنا ماخده انترا مسكلةبينما الـ enteric virus
+
+511
+00:36:46,480 --> 00:36:50,700
+أو ال oral اللي هو ال live أخدناها oral وبالتالي
+
+512
+00:36:50,700 --> 00:36:55,320
+بالفعل ممكن يعملوا interference مع بعض Can cause
+
+513
+00:36:55,320 --> 00:36:58,940
+disease in the immune compromise؟ No بالنسبة
+
+514
+00:36:58,940 --> 00:37:04,580
+لكilled بينما yes بالنسبة ل life إذا ال juice اللي
+
+515
+00:37:04,580 --> 00:37:08,220
+هلوي واضح أنه اللي صالح مين ال life و ال juice
+
+516
+00:37:08,220 --> 00:37:09,860
+الشفلي صالح مين ال kill
+
+517
+00:37:12,980 --> 00:37:16,600
+Route of administration injection and oral التاني
+
+518
+00:37:16,600 --> 00:37:19,960
+oral اورال لان احنا بدنا يتكاثر جوا الأمهات ويعمل
+
+519
+00:37:19,960 --> 00:37:27,280
+induction ل ال IGA production Route
+
+520
+00:37:27,280 --> 00:37:30,020
+of administration oral خلصنا منها requires
+
+521
+00:37:30,020 --> 00:37:34,220
+refrigeration نو ال killed بينما ال life's a being
+
+522
+00:37:34,220 --> 00:37:39,650
+yesفاكرين الجثة اللى حكتكوا عن ال cold transport
+
+523
+00:37:39,650 --> 00:37:42,930
+chain فى ال vaccine ودالكوا ان ال vaccine لازم من
+
+524
+00:37:42,930 --> 00:37:46,950
+المصنع اللى طلع منه لحد ما يصل لمخازن تبعتنا لازم
+
+525
+00:37:46,950 --> 00:37:52,330
+يكون معاه شهادة بتقول انه مر بدرجة حرارة 22 و 21 و
+
+526
+00:37:52,330 --> 00:37:57,130
+نص 22 و نص يعني تاريخ مروره اسمها cold transport
+
+527
+00:37:57,130 --> 00:38:02,050
+chainفبالتالي في بعض ال vaccine من ميزاتها ان انا
+
+528
+00:38:02,050 --> 00:38:04,670
+بحطها على الراف عارفين اني بحطها على الراف ميزات؟
+
+529
+00:38:04,670 --> 00:38:09,090
+لأن التلاجة طاقة طب في غزة انها انا ايش من انا في
+
+530
+00:38:09,090 --> 00:38:12,090
+التلاجة اللي بتفصل؟ بدنا نشغلها المواطين؟ يعني
+
+531
+00:38:12,090 --> 00:38:17,450
+الابقاءها في ظرف ملائم لها في التخزين هذا أمر حيوي
+
+532
+00:38:17,450 --> 00:38:22,010
+وبالتالي هو أمر مكلف هو حيوي نعم وضروري لكن مكلف
+
+533
+00:38:23,570 --> 00:38:27,090
+Duration of immunity في الـ killed بتكون shorter و
+
+534
+00:38:27,090 --> 00:38:31,490
+بالـ live بتكون longer لإنه هي عبارة عن بناء
+
+535
+00:38:31,490 --> 00:38:37,890
+simulation ل natural infection يعني زي محاكاة لمرض
+
+536
+00:38:37,890 --> 00:38:41,190
+حقيقي احنا خدنا ال oral و صار فيه اندي infection و
+
+537
+00:38:41,190 --> 00:38:45,390
+يمكن وصل الدم كمان تمام لكن الفيروس ضعيف وبالتالي
+
+538
+00:38:45,390 --> 00:38:52,000
+تم التخلص منه تماماهذا الفيروس الأول في السلسلة
+
+539
+00:38:52,000 --> 00:38:57,280
+ننتقل الآن لفيروس تاني اسمه كوكساكي virus كوكساكي
+
+540
+00:38:57,280 --> 00:39:01,220
+virus are named for .. named for يعني سمية على اسم
+
+541
+00:39:01,220 --> 00:39:04,220
+اللي هو ال town of كوكساكي موجودة في نيو يورك
+
+542
+00:39:04,220 --> 00:39:08,700
+where they were first isolated يعني تم عزلها في
+
+543
+00:39:08,700 --> 00:39:12,760
+مدينة كوكساكي في منطقة نيو يورك وبالتالي سمية على
+
+544
+00:39:12,760 --> 00:39:19,940
+اسمها الكوكساكي virus بسبب مجموعة من الأمراضبينجسم
+
+545
+00:39:19,940 --> 00:39:25,620
+على group A و group Bالـ .. ال .. ال .. ال .. ال
+
+546
+00:39:25,620 --> 00:39:26,340
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+547
+00:39:26,340 --> 00:39:26,340
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+548
+00:39:26,340 --> 00:39:26,660
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+549
+00:39:26,660 --> 00:39:26,740
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+550
+00:39:26,740 --> 00:39:34,400
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+551
+00:39:34,400 --> 00:39:37,140
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+552
+00:39:37,140 --> 00:39:37,200
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+553
+00:39:37,200 --> 00:39:37,220
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+554
+00:39:37,220 --> 00:39:38,100
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+555
+00:39:38,100 --> 00:39:38,100
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+556
+00:39:38,100 --> 00:39:40,400
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+557
+00:39:40,400 --> 00:39:40,400
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+558
+00:39:40,400 --> 00:39:46,300
+.. ال .. ال .. ال .. ال .. ال
+
+559
+00:39:49,480 --> 00:39:55,500
+في كمان مرض للغاية سيّه اسمه hand, foot and mouth
+
+560
+00:39:55,500 --> 00:40:01,400
+disease بيطلع blisters بيطلع بيطلع بيطلع بيطلع
+
+561
+00:40:01,400 --> 00:40:02,660
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+562
+00:40:02,660 --> 00:40:02,660
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+563
+00:40:02,660 --> 00:40:02,660
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+564
+00:40:02,660 --> 00:40:02,720
+بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع بيطلع
+
+565
+00:40:02,720 --> 00:40:18,600
+بيطلع بيطلع بيطل
+
+566
+00:40:18,640 --> 00:40:21,540
+طبعا هداك اللي .. اللي مولود في الأبقار حصل أنه
+
+567
+00:40:21,540 --> 00:40:24,220
+السنة الماضية أو اللي جابلها وحصل أنه قبل أدت
+
+568
+00:40:24,220 --> 00:40:28,980
+سنوات ونسبة القتل فيه للحيوانات بتكون عالية جدا،
+
+569
+00:40:28,980 --> 00:40:31,840
+يعني فيروس من الفيروسات اللي بيسميها الاقتصادية
+
+570
+00:40:31,840 --> 00:40:36,480
+بتأثر على اقتصاد ال .. البلد وخاصة أنه نتكلم عن
+
+571
+00:40:36,480 --> 00:40:42,940
+قطعان ماشية مكلفة أثمنجروب بي فيروس بتسبب حاجة
+
+572
+00:40:42,940 --> 00:40:49,200
+اسمها pleurodyna وينهدى عبارة عن pain عضلات بين
+
+573
+00:40:49,200 --> 00:40:55,500
+الأضلاع او في الديافرام الحجاب الحاجز myocarditis
+
+574
+00:40:55,500 --> 00:41:01,180
+و pericarditis اذا الكوكساكي فيروس غالبا بيسبب
+
+575
+00:41:01,180 --> 00:41:04,520
+مجموعتين من الأمرض بيسموها group a و group b
+
+576
+00:41:04,520 --> 00:41:06,700
+infection
+
+577
+00:41:09,810 --> 00:41:14,310
+Types cause nonspecific upper respiratory tract
+
+578
+00:41:14,310 --> 00:41:18,250
+disease, common cold, febrile rashes and aseptic
+
+579
+00:41:18,250 --> 00:41:18,790
+meningitis
+
+580
+00:41:39,830 --> 00:41:41,630
+نكمل باقي المجموعات
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/RlFnKtmnv2g_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/RlFnKtmnv2g_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1d866fcc8d4243b9909efd301522ac18421fe97a
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/RlFnKtmnv2g_postprocess.srt
@@ -0,0 +1,2264 @@
+1
+00:00:21,290 --> 00:00:24,570
+بسم الله الرحمن الرحيم نكمل محاضرتنا اللي بدأناها
+
+2
+00:00:24,570 --> 00:00:27,610
+المحاضرة السابقة اللي هي ال viral pathogenesis
+
+3
+00:00:27,610 --> 00:00:33,510
+وبمرور سريع على ال slides هنشوف أنه مستويين لمعرفة
+
+4
+00:00:33,510 --> 00:00:37,430
+ما إذا كانت الفيروسات قادرة على إحداث درر على
+
+5
+00:00:37,430 --> 00:00:44,710
+مستوى الخلية نفسه وعلى مستوى العقل كله في ال
+
+6
+00:00:44,710 --> 00:00:47,640
+infected cell قلنا إنه فيه 4 احتمالاتإنه تكون فيه
+
+7
+00:00:47,640 --> 00:00:50,220
+موت للخلية ممكن يكون صير فيه fusion او
+
+8
+00:00:50,220 --> 00:00:52,920
+multinigrated giant cell او malignant
+
+9
+00:00:52,920 --> 00:00:56,840
+transformation او ما يصير اي تغيير في هذه الخلايا
+
+10
+00:00:56,840 --> 00:01:00,260
+وبدأنا بالحديث عن ال death وقلنا ان ال death
+
+11
+00:01:00,260 --> 00:01:05,660
+بالاساس بينتج غالبا عن قدرة الفيروس على إيقاف
+
+12
+00:01:05,660 --> 00:01:09,840
+تصنيع ال macro molecules وأشهر مثل هذا كان هو ال
+
+13
+00:01:09,840 --> 00:01:13,860
+protein اللي من خلاله ممكن حتى نوجف أشياء أخرى زي
+
+14
+00:01:13,860 --> 00:01:21,360
+ال mRNA أو ال DNAحدثنا كمان في الطريق عن أشياء مثل
+
+15
+00:01:21,360 --> 00:01:24,000
+الـ Intranuclear و Intracytoplasmic Inclusions
+
+16
+00:01:24,000 --> 00:01:26,840
+وقلنا إن هذه الـ Inclusions عامل مهم جدا في عملية
+
+17
+00:01:26,840 --> 00:01:29,620
+الـ Diagnosis للـ Viral Infection واخدنا أمثلة على
+
+18
+00:01:29,620 --> 00:01:33,240
+الـ Nigripodies واخدنا أمثلة على الـ Owls Eye في
+
+19
+00:01:33,240 --> 00:01:37,140
+الـCytomegalovirus شوفنا مثل الصورة هذه اللي هي
+
+20
+00:01:37,140 --> 00:01:39,200
+الـ Nigripodies شوفنا الصورة هذه اللي هي فيها
+
+21
+00:01:39,200 --> 00:01:42,060
+اقولنا Owls Eye بعدين اتكلمنا عن الـ
+
+22
+00:01:42,060 --> 00:01:45,060
+Multinucleogen Cell اللي في الـ Snacks Meal للـ
+
+23
+00:01:45,060 --> 00:01:46,300
+Herpesviruses
+
+24
+00:01:51,740 --> 00:01:53,800
+اتكلمنا عن ال infected patients بيقولوا انه فيه
+
+25
+00:01:53,800 --> 00:01:57,160
+transmission و replication و spread للفيروس و
+
+26
+00:01:57,160 --> 00:02:01,020
+بعدين immune response غالبا عند رقم أربع تنتهي ال
+
+27
+00:02:01,020 --> 00:02:03,400
+viral infection لكن عند بعض ال immunocompromised
+
+28
+00:02:03,400 --> 00:02:05,720
+بيصير فيه ادنى نوع منه اللي هو ال persistence
+
+29
+00:02:05,720 --> 00:02:09,840
+infection و عايشه برضه في المحاضرة هذه و المراحل
+
+30
+00:02:09,840 --> 00:02:13,060
+اللي بيمر فيها المريض incubation period, prodromal
+
+31
+00:02:13,060 --> 00:02:15,900
+period وشرحناها و ان هي الفترة اللي بيشعر فيها
+
+32
+00:02:15,900 --> 00:02:19,940
+الإنسان بيه أعراض non specific بينما المرحلة
+
+33
+00:02:19,940 --> 00:02:23,590
+التالتة هي ال specificبإلنس period بعد ال recovery
+
+34
+00:02:23,590 --> 00:02:27,070
+period أو قولنا كلمة مرة some people will have
+
+35
+00:02:27,070 --> 00:02:30,580
+persisted infectionال transmission و ال portal of
+
+36
+00:02:30,580 --> 00:02:33,000
+entry اتكلمنا على انه اكتر من portal of entry
+
+37
+00:02:33,000 --> 00:02:37,460
+للفيروس و ركزنا على ال ال ال person to person و
+
+38
+00:02:37,460 --> 00:02:40,920
+أخدنا مجموعة من العراض من ال ال ال roots اللي هم
+
+39
+00:02:40,920 --> 00:02:43,600
+ال respiratory secretions ال saliva ال blood السمن
+
+40
+00:02:43,600 --> 00:02:47,140
+و fecal contamination و اتكلمنا على ان ال blood
+
+41
+00:02:47,140 --> 00:02:51,300
+ممكن يكون من transfusion في المستشفى يعني او من
+
+42
+00:02:51,300 --> 00:02:54,060
+خلال اللي هو ال needle sharing و ادنو اكتر اكتر و
+
+43
+00:02:54,060 --> 00:02:58,510
+اتكلمنا عن ال animal كمانالـ Transmission يقولنا
+
+44
+00:02:58,510 --> 00:03:01,970
+كلمة Direct و Indirect Direct عن طريق العض
+
+45
+00:03:01,970 --> 00:03:05,870
+للحيوانات إن الحيوان يعض الإنسان أو عن طريق
+
+46
+00:03:05,870 --> 00:03:12,670
+الحشرات اللي هي ال vectors زي اللي هو البعض وخدنا
+
+47
+00:03:12,670 --> 00:03:16,830
+أنثى على ال viruses لكل portal of entry و أكثر
+
+48
+00:03:16,830 --> 00:03:19,170
+portal of entry كان common اللي هو ال respiratory
+
+49
+00:03:19,170 --> 00:03:22,310
+و بعدين كده مع ال .. ال .. ال gastrointestinal
+
+50
+00:03:22,310 --> 00:03:26,010
+tract و ال skin و ال genital tract و ركزنافي ال
+
+51
+00:03:26,010 --> 00:03:30,970
+transplacental و ال vertical transmission على اللي
+
+52
+00:03:30,970 --> 00:03:36,550
+هو during pregnancy in utero يعني في الرحم و أثناء
+
+53
+00:03:36,550 --> 00:03:38,730
+الولادة و كنا في الرضا
+
+54
+00:03:41,280 --> 00:03:44,980
+بعدين أعتقد توقفنا أو انتهينا عند هذه اللوحة لما
+
+55
+00:03:44,980 --> 00:03:51,280
+ذكرنا بعض الفيروسات اللي بتنتقل عن طريق الحيوانات
+
+56
+00:03:51,280 --> 00:03:55,280
+أو اللي إلها animal reservoir يعني مخزن حيواني
+
+57
+00:03:55,280 --> 00:03:59,920
+والمخزن الحيواني نؤكد على أنه هو الحيوان المصاب أو
+
+58
+00:03:59,920 --> 00:04:04,660
+الحامل لهذا الفيروس الذي يمكن من خلاله انتقال
+
+59
+00:04:04,660 --> 00:04:10,440
+الفيروس إلى الإنسان وبرضه اتطرحنا لكلمة localized
+
+60
+00:04:11,000 --> 00:04:13,580
+and disseminated infection وميزنا بين التنتين
+
+61
+00:04:13,580 --> 00:04:17,080
+أخدنا مثال على ال localized اللي هو ال common cold
+
+62
+00:04:17,080 --> 00:04:20,860
+و ال influenza و أخدنا واحد على ال disseminated و
+
+63
+00:04:20,860 --> 00:04:23,940
+ال poliovirus و رأينا كيف بالفعل بيصل إلى ال
+
+64
+00:04:23,940 --> 00:04:28,540
+nervous system في
+
+65
+00:04:28,540 --> 00:04:34,300
+اللوحة هذه اللي أمامنا لوحة مخيفة بتوضح لنا أن one
+
+66
+00:04:34,300 --> 00:04:40,280
+virus that contains three proteinsهذه البروتينز
+
+67
+00:04:40,280 --> 00:04:45,460
+كلها لديها فرصة مختلفة، الأولى هي الاتشمنت، وكلمة
+
+68
+00:04:45,460 --> 00:04:47,940
+الاتشمنت انتوا عارفين هي الخطوة الأولى في الـ
+
+69
+00:04:47,940 --> 00:04:52,340
+replication، وبالتالي هذا الفيروس اللي عمل
+
+70
+00:04:52,340 --> 00:04:54,940
+الاتشمنت هو اللي بيحدد ما يسمى بالـ tissue
+
+71
+00:04:54,940 --> 00:04:57,440
+tropism، عارفين شو ال tissue tropism؟ اللي هو ال
+
+72
+00:04:57,440 --> 00:05:03,370
+specificity لل tissueرقم اتنين، البروتين هذا اللي
+
+73
+00:05:03,370 --> 00:05:08,170
+احنا بالان نتكلم عنه، وظيفته الأساسية يعطي الفيروس
+
+74
+00:05:08,170 --> 00:05:11,970
+قدرة على مقاومة الإنزيمات الهاضمة للبروتينات، مش
+
+75
+00:05:11,970 --> 00:05:16,290
+الفيروس اللي بناخده مثلا مع الأكل أو الشرببيمر عبر
+
+76
+00:05:16,290 --> 00:05:18,950
+المعدة والانتستين، المعدة والانتستين فيهم
+
+77
+00:05:18,950 --> 00:05:23,170
+proteolytic enzymes، these proteolytic enzymes لو
+
+78
+00:05:23,170 --> 00:05:27,410
+اشتغلت عن جد، ايش هتعمل؟ هتكسر الفيروس، هذا
+
+79
+00:05:27,410 --> 00:05:31,450
+البروتين بيعطي الفيروس القدرة على انه يقاوم هذه
+
+80
+00:05:31,450 --> 00:05:35,530
+الانزيمات اللي هي ال proteolytic enzymeوالبروتين
+
+81
+00:05:35,530 --> 00:05:41,170
+الثالث وهو الأخطر على الإطلاق الذي يمنع من تكون ال
+
+82
+00:05:41,170 --> 00:05:45,850
+RNA و البروتين في الخلايا المصابة يبقى الآن هو
+
+83
+00:05:45,850 --> 00:05:51,110
+يثبت كل العمليات الحيوية لأنه تذكروا ان كل
+
+84
+00:05:51,110 --> 00:05:55,330
+البروتينات كل البروتينات او كل الانزمات عفوا هي
+
+85
+00:05:55,330 --> 00:06:00,970
+بروتينات فإذا توقفنا عن تصنيعالانزيمات الخلية لن
+
+86
+00:06:00,970 --> 00:06:04,630
+تستطيع ان تقوم بأي عمليات متابوليزم فستتسخر فقط
+
+87
+00:06:04,630 --> 00:06:10,390
+لمين اللي هو الفيروس طبعا هذا ال ال ال ال بروتين
+
+88
+00:06:10,390 --> 00:06:13,590
+الثالث يعتقد انه لدور كبير فيه انه ال infection
+
+89
+00:06:13,590 --> 00:06:16,530
+يصير لها persistence persistence يعني تبقى لفترة
+
+90
+00:06:16,530 --> 00:06:23,440
+طويلة اللي هو هذه شرحناهالما .. لما تحدثنا عن ال
+
+91
+00:06:23,440 --> 00:06:26,960
+polio و قولنا ان ال poliovirus بيصل ال intestine،
+
+92
+00:06:26,960 --> 00:06:30,020
+بيتكاتر في ال intestinal tract، بعدين بيروح على ال
+
+93
+00:06:30,020 --> 00:06:32,920
+mesenteric lymph node و من ال mesenteric lymph
+
+94
+00:06:32,920 --> 00:06:36,500
+node بيروح على الدم و من الدم بيروح على many
+
+95
+00:06:36,500 --> 00:06:40,720
+organsو من ال many organs بتكاتر نيجي فيها مرة
+
+96
+00:06:40,720 --> 00:06:45,100
+أخرى و بيرجع مرة تانية عليا على الدم و من الدم
+
+97
+00:06:45,100 --> 00:06:48,680
+المرة هيبنتقل لل central nervous system إذا هذا
+
+98
+00:06:48,680 --> 00:06:54,280
+نموذج رائع على disseminated viral infection بعكس
+
+99
+00:06:54,280 --> 00:06:58,040
+ال common cold اللي كان عنه localized infection
+
+100
+00:06:58,040 --> 00:07:05,170
+طيب احنا تحدثنابشكل عام عن الفيروسات تعالوا نطلع
+
+101
+00:07:05,170 --> 00:07:09,390
+دلوقتي كيف بالضبط الفيروس بيعمل pathogenesis كيف
+
+102
+00:07:09,390 --> 00:07:13,150
+بالضبط بيقتل الخلية كيف بالضبط الخلية بتموت سواء
+
+103
+00:07:13,150 --> 00:07:16,550
+من الفيروس او من غير الفيروس لأن كلمة immune و
+
+104
+00:07:16,550 --> 00:07:20,790
+pathogenesis على طول انتبهولها هي إشارة على أن
+
+105
+00:07:20,790 --> 00:07:26,130
+الموت و الدرر هو ناجم عن مين؟ ناجم عن خلايانا احنا
+
+106
+00:07:26,130 --> 00:07:29,250
+ناجم عن خلايا احنا عن جهاز المناعة تبعنا هو الذي
+
+107
+00:07:29,250 --> 00:07:34,970
+يهاجم الخلايا المصارعة بالفيروس ويقتلهاthe signs
+
+108
+00:07:34,970 --> 00:07:37,590
+and symptoms كل الأعراض اللي بتظهر لل viral
+
+109
+00:07:37,590 --> 00:07:44,930
+infection بتكون ناتجة عن ال cell killing لمن؟ لل
+
+110
+00:07:44,930 --> 00:07:47,710
+virus by virus induced inhibition of
+
+111
+00:07:47,710 --> 00:07:50,850
+macromolecular synthesis الفيروس منع تكوين
+
+112
+00:07:50,850 --> 00:07:54,730
+لبروتينات في الخلية و الخلية ماتت لما يموت مجموعة
+
+113
+00:07:54,730 --> 00:07:58,280
+كبيرة من الخلايا في organ ايش بصير انها؟حالة
+
+114
+00:07:58,280 --> 00:08:03,040
+نسميها loss of function يعني نفترض أن الكبد كبد
+
+115
+00:08:03,040 --> 00:08:08,970
+أرجع، إله وظائف متنوعة، جزء كبير من خلايا ماتهذا
+
+116
+00:08:08,970 --> 00:08:12,490
+الجزء الكبير ألم يكن يؤدي وظيفة كان يؤدي وظيفة
+
+117
+00:08:12,490 --> 00:08:17,810
+دلوقتي تظهر فينا إما نقصان أو فقدان في هذه الوظيفة
+
+118
+00:08:17,810 --> 00:08:21,730
+يبقى ال loss of function مثلا في ال liver بيعطينا
+
+119
+00:08:21,730 --> 00:08:25,090
+اللون الأصفر اللي بنشوفه عن مرضى ال hepatitis لأنه
+
+120
+00:08:25,090 --> 00:08:29,750
+غير قادر على معالجة ال بالوروبيين على سبيل المثال
+
+121
+00:08:29,750 --> 00:08:37,930
+example تاني Polio virus kills motor neuronsقتل
+
+122
+00:08:37,930 --> 00:08:42,250
+الخلايا العصبية يبقى معناه الحكي كل العضلات
+
+123
+00:08:42,250 --> 00:08:48,290
+المرتبطة بهذا العصب ايش حصل فيها شلل يبقى فقدان
+
+124
+00:08:48,290 --> 00:08:54,390
+الوظيفة هو اللي قد الى العرض اللي اسمه شلل ال
+
+125
+00:08:54,390 --> 00:08:57,370
+hemorrhage او ال hemorrhage is caused by Ebola
+
+126
+00:08:57,370 --> 00:09:01,430
+virus نتجا عن ايش ال hemorrhage هذا عرض لمرض
+
+127
+00:09:01,430 --> 00:09:06,120
+الابولا نتجا عن ايش بقولناانتوا بتعرفوا انه الـ
+
+128
+00:09:06,120 --> 00:09:08,580
+capillaries و ال veins و ال arteries are
+
+129
+00:09:08,580 --> 00:09:12,800
+innervated يعني مبطنة ب endothelial cells ..
+
+130
+00:09:12,800 --> 00:09:16,860
+endothelial cells الان ال virus بيجي بيرطبط في ال
+
+131
+00:09:16,860 --> 00:09:21,120
+.. او بيدخل داخلها و بدمرها لما يدمرها و يدمر اللي
+
+132
+00:09:21,120 --> 00:09:22,840
+وراها و اللي وراها و اللي وراها .. ايه مثلا في
+
+133
+00:09:22,840 --> 00:09:28,780
+عندي .. مثلا عندي .. هذا tubeالتيوب اللي ممشي فيه
+
+134
+00:09:28,780 --> 00:09:33,640
+الدم مظبوط الآن التيوب هذا صار فيه دنج للخلايا
+
+135
+00:09:33,640 --> 00:09:38,900
+بتاعة الجدار تبعته تدريجيا تختفي الخلايا لحد ما
+
+136
+00:09:38,900 --> 00:09:44,040
+يصير انها ثقب يبقى الدم الآن سيخرج من هذا الثقب
+
+137
+00:09:44,040 --> 00:09:47,720
+يعني hemorrhage اذا كان انا بتكلم عن viral
+
+138
+00:09:47,720 --> 00:09:52,540
+infection في كل الجسم يبقى كل الجسم عرضة انه يصير
+
+139
+00:09:52,540 --> 00:09:54,820
+فيه hemorrhage من هذا ال virus
+
+140
+00:09:58,450 --> 00:10:03,510
+طبعا مش كل الأمراض الفيروسية بتنتج عن انه ال .. ال
+
+141
+00:10:03,510 --> 00:10:06,990
+virus بيعمل damage لل .. او killing لل infected
+
+142
+00:10:06,990 --> 00:10:10,690
+cell مثلا في virus زي ال rotavirus و ال rotavirus
+
+143
+00:10:10,690 --> 00:10:14,030
+صار شهير جدا بالنسبة لنا انه بيعمل اسهال عند
+
+144
+00:10:14,030 --> 00:10:18,070
+الأطفال الاسهال تبعه مش ناتج عن قتل الخلايا و انما
+
+145
+00:10:18,070 --> 00:10:24,290
+عن stimulation ل ال enteric nervous systemهو بيعمل
+
+146
+00:10:24,290 --> 00:10:27,830
+stimulation للفيروس هذا فالـ Enteric Nervous
+
+147
+00:10:27,830 --> 00:10:32,470
+System ال stimulation تبقى بينتج عنه excess fluid
+
+148
+00:10:32,470 --> 00:10:35,010
+و electrolyte وبالتالي فاكرين ال electrolyte هو
+
+149
+00:10:35,010 --> 00:10:38,170
+أساس أصلا أي ديارية ال accumulation of
+
+150
+00:10:38,170 --> 00:10:42,930
+electrolytes بيعتبر الدسم سامة وبيبدأ يعملها
+
+151
+00:10:42,930 --> 00:10:46,790
+dilution بإنه يفرز عليها كمية كبيرة من الماء أو من
+
+152
+00:10:46,790 --> 00:10:47,330
+السواق
+
+153
+00:10:50,280 --> 00:10:54,500
+للـ virally infected cell أدى إلى loss of function
+
+154
+00:10:54,500 --> 00:10:59,560
+أدى إلى أعراض أو صار في stimulation ل nerve، ال
+
+155
+00:10:59,560 --> 00:11:06,380
+nerve عمل وظيفة معينة أدت برضه إلى أعراض الآن
+
+156
+00:11:06,380 --> 00:11:11,840
+نوع تالت ناجم عن killing by immunologic attack
+
+157
+00:11:11,840 --> 00:11:16,200
+plays an important role in the pathogenesisكل من
+
+158
+00:11:16,200 --> 00:11:20,180
+الـ cytotoxic T cell و ال antibody بيلعب دور في
+
+159
+00:11:20,180 --> 00:11:25,680
+هذه العملية و أفضل نموذج تم دراسته انتبهوا علينا
+
+160
+00:11:25,680 --> 00:11:29,500
+كويس هشرحلكوا إياه بطريقة مختلفة شوية عن اللي
+
+161
+00:11:29,500 --> 00:11:34,700
+موجودة على الصبورة لكن بنفس المفهوم لدينا فقر فقر
+
+162
+00:11:34,700 --> 00:11:39,960
+ذو مناعة حسنة يعني مناعته جيدةحقنها في الدماغ
+
+163
+00:11:39,960 --> 00:11:44,160
+بالفيروس اللي اسمه lymphocytic choriomeningitis
+
+164
+00:11:44,160 --> 00:11:49,840
+virus أو LCM فيروس على طول الفيروس خلال فترة وجيزة
+
+165
+00:11:49,840 --> 00:11:55,900
+بيبدأ تظهر لأعراض و بيموت أمر طبيعي أنه إذا فيرا
+
+166
+00:11:55,900 --> 00:12:01,820
+ال infection خطيرة ممكن يموت الفيروس احنا كنا نظر
+
+167
+00:12:01,820 --> 00:12:05,920
+زمان أن الموت ناتج عن مين؟ عن أن الفيروس دمر
+
+168
+00:12:05,920 --> 00:12:06,880
+الخلايا
+
+169
+00:12:09,180 --> 00:12:14,500
+أثار انتباه العلماء تجربة انهم عملوا حقن لنفس
+
+170
+00:12:14,500 --> 00:12:21,820
+الفيروس في فقران ذوي مناعة منخفضة الفيروس تكاثر
+
+171
+00:12:21,820 --> 00:12:27,220
+جوا الفقران لكن الفقر لم يموت جابوا فقران baby
+
+172
+00:12:27,220 --> 00:12:31,060
+للسيمولوجين حديثا تمام فحقنوها بالفيروس الفيروس
+
+173
+00:12:31,060 --> 00:12:40,480
+تكاثر فيها لكن الفقر لم يموتلما اعطوهم سواء كان ذو
+
+174
+00:12:40,480 --> 00:12:44,780
+المناعة المنخفضة او ال baby الفقر لما اعطوهم خلايا
+
+175
+00:12:44,780 --> 00:12:52,540
+منعية التنينماتوم فالولماء صار عندهم الآن شك بانه
+
+176
+00:12:52,540 --> 00:12:59,060
+الموت ناتج عن ال attack caused by cytotoxic T cell
+
+177
+00:12:59,670 --> 00:13:03,950
+بتهاجم ال virus infected cell و بتقتلها لما يكون
+
+178
+00:13:03,950 --> 00:13:08,210
+ال virus infected cell مليانة كتيرة تمام؟ القتل
+
+179
+00:13:08,210 --> 00:13:12,530
+هيكون برضه كتير لما يكون القتل كتير ال loss of
+
+180
+00:13:12,530 --> 00:13:16,530
+function ممكن يكون عالي جدا وبالتالي يؤدي الى
+
+181
+00:13:16,530 --> 00:13:21,750
+الوفاة إذا في هذه الحالة من المسئول عن العراض؟ هل
+
+182
+00:13:21,750 --> 00:13:25,930
+هو ال virus أو ال proteinato أو ال stimulation لل
+
+183
+00:13:25,930 --> 00:13:28,230
+nerve ولا المسئول كان مين؟
+
+184
+00:13:37,390 --> 00:13:41,150
+بنعرف أن جهاز المنع له دور في هذه الحالة
+
+185
+00:13:49,440 --> 00:13:52,880
+الـ Cytotoxic T Cell أيضًا كان لها دور كبير في
+
+186
+00:13:52,880 --> 00:13:56,240
+مجموعة من الأمراض المعروفة لدينا هي الـ Hepatitis
+
+187
+00:13:56,240 --> 00:14:00,740
+A والـ B والـ C فيروس وإن هذه الفيروسات الثلاثة
+
+188
+00:14:00,740 --> 00:14:07,200
+اللي ذكرناهم لا تحدث أي effect في خلايا الكبد إذا
+
+189
+00:14:07,200 --> 00:14:14,060
+ما الذي يقتل خلايا الكبد هو مهاجمة الـ Cytotoxic T
+
+190
+00:14:14,060 --> 00:14:19,740
+Cell في محاولتهالأداء دورها .. أداء دورها .. دورها
+
+191
+00:14:19,740 --> 00:14:24,120
+الأساسي أو أحد أدوارها الأساسية البحث عن الخلايا
+
+192
+00:14:24,120 --> 00:14:29,280
+المصابة ومن ثم قتلها حتى تمنا .. يعني تقتلها مش من
+
+193
+00:14:29,280 --> 00:14:34,650
+أجل القتلجواها فيه فيروسات إذا الفيروسات اللي
+
+194
+00:14:34,650 --> 00:14:40,190
+جواها تتركوا هيتكاثروا وينطلقوا إلى خلايا أخرى فهي
+
+195
+00:14:40,190 --> 00:14:45,010
+بتقول إن أنا بقتل الخلية فبقتل مين إمكاني تكاثر
+
+196
+00:14:45,010 --> 00:14:49,230
+الفيروس وانتقاله إلى خلايا أخرى في هذه المحاولة هي
+
+197
+00:14:49,230 --> 00:14:53,550
+مابتكونش عارفة جداش في خلايا أصلا مصابة تخيلوا لو
+
+198
+00:14:53,550 --> 00:14:57,410
+ال organ كله مصاب يقول كله إيش؟ هيتدمر من قبل ال
+
+199
+00:14:57,410 --> 00:15:02,610
+cytotoxicity cellالـ Rashes اللي هي الطفح اللي
+
+200
+00:15:02,610 --> 00:15:08,590
+بينتج عند مرضى الحصبة، أيضًا ناتج عن ال attack لل
+
+201
+00:15:08,590 --> 00:15:13,770
+T-cells لل Vascular Endothelial أو Endothelium of
+
+202
+00:15:13,770 --> 00:15:18,290
+the skin، إذن بنقدر نقول إن الجهاز المناع بالفعل
+
+203
+00:15:18,290 --> 00:15:23,210
+له دور في ظهور بعض الأعراض أو أثار الأعراض اللي في
+
+204
+00:15:23,210 --> 00:15:28,730
+ال viral infected patientفي كمان شغل تاني مهمة
+
+205
+00:15:28,730 --> 00:15:32,530
+مالك علاقة بالـ cytotoxic T cell وإنما إليها علاقة
+
+206
+00:15:32,530 --> 00:15:38,690
+بالـ antibody و ال complement و ال virus itself
+
+207
+00:15:38,690 --> 00:15:44,590
+كيف؟ ال virus عبارة عن particlesقلنا عليها
+
+208
+00:15:44,590 --> 00:15:50,430
+بروتينات هذه البروتينات تشكل أنتيجينات الانتيجينات
+
+209
+00:15:50,430 --> 00:15:55,050
+بتكون لها اجسام antibodies ال antibodies بتتفاعل
+
+210
+00:15:55,050 --> 00:16:01,710
+مع هذه الانتيجينات فيروس مرتبط بانتيبادي بنسميه
+
+211
+00:16:01,710 --> 00:16:05,350
+antigen-antibody complex أو virus-antibody complex
+
+212
+00:16:05,350 --> 00:16:25,750
+بنفلفه في الدم هيترسبه في أنسجة معينةالان الـ
+
+213
+00:16:25,750 --> 00:16:32,440
+complement هتقتل أي خلية؟يعني .. يعني الآن الـ
+
+214
+00:16:32,440 --> 00:16:35,620
+complexes مترسمين على نسيج وصار activation للـ
+
+215
+00:16:35,620 --> 00:16:38,960
+complement بيصير القاتل لمين؟ للخلالة أو للأنسجة
+
+216
+00:16:38,960 --> 00:16:42,900
+اللي مرد عليها هذه الـ complexes لذلك بتلاقي انه
+
+217
+00:16:42,900 --> 00:16:46,740
+بعض ال viral diseases بيصير فيها زي Arthritis زي
+
+218
+00:16:46,740 --> 00:16:50,930
+Hepatitis Bطب الـ Hepatitis B ما بيعملش مشاكل
+
+219
+00:16:50,930 --> 00:16:54,710
+كفيروس إلا في الـ Covid، إيش اللي خلّى يسينا أنها
+
+220
+00:16:54,710 --> 00:16:59,210
+الـ Arthritis؟ التفسير الوحيد هو أن هناك ترسيب لـ
+
+221
+00:16:59,210 --> 00:17:03,290
+Antigen Antibody Complexes في المفاصل أدت إلى
+
+222
+00:17:03,290 --> 00:17:05,950
+destruction .. activation الكملة و destruction
+
+223
+00:17:05,950 --> 00:17:10,160
+الخلايا، فحصل أن ما يسمع بيه الـ Arthritisهذا
+
+224
+00:17:10,160 --> 00:17:14,380
+الكلام كمان بنشوفه في بعض ال .. ال other viruses
+
+225
+00:17:14,380 --> 00:17:18,340
+او ال viral infection زي ال Parvovirus B19 و ال
+
+226
+00:17:18,340 --> 00:17:23,080
+Rubella virus infection هقولكوا في حاجة كمان مثال
+
+227
+00:17:23,080 --> 00:17:29,080
+صارخ على immune complexes و بطريقة عجيبة لأن ال
+
+228
+00:17:29,080 --> 00:17:33,200
+baby المولود جديد بياخد ال antibodies غالبا ماخدهم
+
+229
+00:17:33,200 --> 00:17:37,860
+placental من مين؟ من أمه او عبر الرضاعة من الحليب
+
+230
+00:17:39,780 --> 00:17:43,320
+لكن ال IGG غالباً Placental، ال IGG Placental لو
+
+231
+00:17:43,320 --> 00:17:46,540
+الطفل هذا اتعرض لفيروس اسمه RSV اللي هو
+
+232
+00:17:46,540 --> 00:17:50,920
+Respiratory Syncytial Virus بيصير عنده نيومونيا
+
+233
+00:17:50,920 --> 00:17:53,560
+الطباء كانوا فاكرين زي ما قالوا العرباء كانوا
+
+234
+00:17:53,560 --> 00:17:56,720
+فاكرين ان نيومونيا ناتجة عن تكاثر الفيروس في ال
+
+235
+00:17:56,720 --> 00:18:01,680
+lungs في الآخر اكتشفوا ان ال ال maternal
+
+236
+00:18:01,680 --> 00:18:04,980
+antibodies اللي هي ال antibodies اللي ماخدها الطفل
+
+237
+00:18:04,980 --> 00:18:08,520
+من الأم هذه بيسموها maternal antibodiesترتبط
+
+238
+00:18:08,520 --> 00:18:12,640
+بالفيروس complexes في ال lung لأنه بيعمل infection
+
+239
+00:18:12,640 --> 00:18:16,020
+في ال lung، هذا الإرتباط بيعمل activation لل
+
+240
+00:18:16,020 --> 00:18:18,740
+complement، بتهاجم الخلايا تبع ال lungs، بينتج
+
+241
+00:18:18,740 --> 00:18:23,280
+عنها أعراض النيمونية، إذا ال immune أو ال
+
+242
+00:18:23,280 --> 00:18:27,440
+immunopathogenesis can manifest either by direct
+
+243
+00:18:27,440 --> 00:18:32,900
+attackمن قبل الـ cytocytic cell للأنسجة أو من خلال
+
+244
+00:18:32,900 --> 00:18:37,380
+الـ deposition اللي هو الارتباط يعني أو الترسيب
+
+245
+00:18:37,380 --> 00:18:40,660
+الـ antibody complexes على هذه الأنسجة وبالتالي
+
+246
+00:18:40,660 --> 00:18:47,660
+تنشيط جنمين الكمبيوتر طيب نجي لمصطلح اسمه
+
+247
+00:18:47,660 --> 00:18:50,760
+virulence وال virulence يا جماعة درسناها في
+
+248
+00:18:50,760 --> 00:18:56,320
+البكتيريا على أن أيتركيب أي أنزيم أو أي أداة من
+
+249
+00:18:56,320 --> 00:19:02,040
+الأدوات بتساعد الكائن على إحداث المرض أو شدة المرض
+
+250
+00:19:02,040 --> 00:19:07,500
+بنتكلم عن نقطة الآن مهمة اسمها strain variability
+
+251
+00:19:07,500 --> 00:19:14,200
+نقول ان احنا ممكن نلتقط مرض ال influenza عدة مرات
+
+252
+00:19:14,200 --> 00:19:18,260
+في السنة او عدة مرات في حياتنا وتجاربنا في ال
+
+253
+00:19:18,260 --> 00:19:22,980
+influenza بتقول انهالمرض بتكون خفيفة تلات أيام و
+
+254
+00:19:22,980 --> 00:19:27,080
+بتعدر بسرعة و ممكن تقعد أسبوع و تكون مدعاة لإنه
+
+255
+00:19:27,080 --> 00:19:30,280
+يبقى الإنسان في الفراش و لا يستطيع أن يمارس حتى
+
+256
+00:19:30,280 --> 00:19:34,340
+الأعمال و هناك بعض المشاهدات و الملاحظات إن في ناس
+
+257
+00:19:34,340 --> 00:19:39,460
+بتموت و أنا ذكرتلكوا في سياق المحاضرة السابقة إن
+
+258
+00:19:39,460 --> 00:19:43,520
+ال avian influenza نسبة اللي وفيها تفاقق تلات ستين
+
+259
+00:19:43,520 --> 00:19:47,500
+بالمئةبينما ال influenza العادية نص الى خمسة
+
+260
+00:19:47,500 --> 00:19:50,640
+بالمائة ال influenza الخنازير اقل من ذلك اذا هذه
+
+261
+00:19:50,640 --> 00:19:52,740
+نقطة بنكون فاهمينها انا بتكلم عن strain
+
+262
+00:19:52,740 --> 00:19:58,120
+variability مش كل ال strains عندهم نفس القدرة على
+
+263
+00:19:58,120 --> 00:20:02,020
+ال virus حتى لو بتكلم عن نفس ال virus مثلا بنقول
+
+264
+00:20:02,020 --> 00:20:05,620
+influenza لكن different strains common cold,
+
+265
+00:20:05,720 --> 00:20:09,540
+adenovirus او rhinovirus different strains فال
+
+266
+00:20:09,540 --> 00:20:15,270
+strain مرتبط فيه جنة اللى هو ال virus السابعمن
+
+267
+00:20:15,270 --> 00:20:18,230
+الأمثلة الصارقة على الـ variation في ال .. في ال
+
+268
+00:20:18,230 --> 00:20:19,610
+.. في ال .. في ال .. في الـ virulence في الـ
+
+269
+00:20:19,610 --> 00:20:24,310
+strains الـ polio ال poliovirus أحد السلالات اللي
+
+270
+00:20:24,310 --> 00:20:29,230
+تم العمل على إحداث طفرات فيها مرارا و تكرارا حصلنا
+
+271
+00:20:29,230 --> 00:20:33,470
+على سلالة قادرة على التكاثر .. قادرة على التكاثر
+
+272
+00:20:33,470 --> 00:20:37,690
+لكن غير قادرة على إحداث المرض إذا non-pathogenic
+
+273
+00:20:37,690 --> 00:20:41,430
+at all تخيلوا ما أنه شيل الأطفال نتكلم عن
+
+274
+00:20:41,430 --> 00:20:46,570
+poliovirus مرض خطير جداوهذا او هذه الطفرة او هذه
+
+275
+00:20:46,570 --> 00:20:52,970
+السلالة المطفرة تم استخدامها في تكوين او تصنيع
+
+276
+00:20:52,970 --> 00:20:59,970
+اللي هو ال vaccine المشهور ل ال polio كيف يمكن لل
+
+277
+00:20:59,970 --> 00:21:04,570
+فيروس ان يخدع جهاز المناع او يتخطى جهاز المناع؟
+
+278
+00:21:04,570 --> 00:21:10,380
+الحقيقةاقراولي اخر جملة او اخر كلمتين في اخر سطر
+
+279
+00:21:10,380 --> 00:21:16,540
+cytokines decoy decoy معناها التفاف تحايل cytokine
+
+280
+00:21:16,540 --> 00:21:22,420
+decoy ايش الفكرة فيه تخيلوا انه جهاز المناع مكون
+
+281
+00:21:22,420 --> 00:21:26,060
+من عناصر متنوعة احد هذه العناصر اللي هم ال
+
+282
+00:21:26,060 --> 00:21:29,560
+messengers شو ال messengers يعني يعني اللي بينقل
+
+283
+00:21:29,560 --> 00:21:34,200
+رسائل لما يطلع لما تلاقوا interlocking واحدمانا
+
+284
+00:21:34,200 --> 00:21:38,400
+حاجة تفهمه زى ما انا مراكه واحد تفهمه ان انا بدي
+
+285
+00:21:38,400 --> 00:21:42,680
+حاجة واحدة اذا عملت اتنين تفهمه حاجة تانية اذا
+
+286
+00:21:42,680 --> 00:21:46,760
+عملت اتناش حاجة رابعة او خمسة او سادسة اذا في
+
+287
+00:21:46,760 --> 00:21:52,200
+اشارات تفهمها الخلايا بنسميها ال cytokines ال
+
+288
+00:21:52,200 --> 00:21:55,740
+cytokines عبارة عن مركبات تنتجها خلايا المنعية
+
+289
+00:21:55,740 --> 00:22:00,580
+ولها مدلولات معينة مثلا cytokine X بنشر خلايا من
+
+290
+00:22:00,580 --> 00:22:09,610
+نوع Y الاخرىالان تخيلوا جهاز المناع بدون هذا الـ
+
+291
+00:22:09,610 --> 00:22:17,730
+cytokines كالجيش الذي ينتلك كل عناصر القوة و ليس
+
+292
+00:22:17,730 --> 00:22:23,650
+لديه القدرة على التواصل أقوى جيش في العالم .. أقوى
+
+293
+00:22:23,650 --> 00:22:26,950
+جيش في العالم لو فقد القدرة على التواصل ستصيبه
+
+294
+00:22:26,950 --> 00:22:32,610
+الهزيمة بالتأكيد طب كيف؟هذا جيوش كيف الفيروسات
+
+295
+00:22:32,610 --> 00:22:38,410
+بتشتغل الشغل هذا جاي معاها كودونز كودونز يعني مادة
+
+296
+00:22:38,410 --> 00:22:44,710
+يراثية تمام بتطلع بروتينات هذه البروتينات بتعمل
+
+297
+00:22:44,710 --> 00:22:50,330
+حاجة من تنتين حاجة من تنتين يا اما ترتبط بال
+
+298
+00:22:50,330 --> 00:22:56,940
+cytokine مباشرة تمنعه ان يقدم مهمتهأو بتروح و
+
+299
+00:22:56,940 --> 00:23:00,700
+بتجفله على الباب اللي بده من خلاله يطلع عشان يقدّي
+
+300
+00:23:00,700 --> 00:23:11,420
+مهمته عشان الباب نركز مع بعض هاي الخلية الفيروسية
+
+301
+00:23:11,420 --> 00:23:16,560
+اللي عفوها الخلية ال host و جواها الفيروس الان لما
+
+302
+00:23:16,560 --> 00:23:20,720
+صارت virally infected cell هي حابة هي تشرج جهاز
+
+303
+00:23:20,720 --> 00:23:28,390
+المنعمعها فبتنتج Interleukin Xالانترالكين X بيطلع
+
+304
+00:23:28,390 --> 00:23:32,070
+ويروح على خلية تانية صح؟ عشان يؤدي المعامل متبعته
+
+305
+00:23:32,070 --> 00:23:37,870
+فالفيروس اش بيعمل بينتج نوعين من البروتين اما ان
+
+306
+00:23:37,870 --> 00:23:42,270
+هو الأول اما بيرتبط فيه هو وبيشله بيمنع خروجه
+
+307
+00:23:42,270 --> 00:23:46,270
+أساسا من المكان او بيروح بطلع برا هو وبيسد عليه
+
+308
+00:23:46,270 --> 00:23:51,330
+المكان اللي بيدخل منه على خلية تانيةالـ cytokine
+
+309
+00:23:51,330 --> 00:23:56,390
+فشل في أداء مهمته، إيش سبب الفشل؟ وجود قدرة
+
+310
+00:23:56,390 --> 00:24:01,150
+للفيروس على إنتاج بروتين يعادل تأثير هذا الـ
+
+311
+00:24:01,150 --> 00:24:08,370
+cytokine، هذه الحقيقة يعني حاجة كبيرة ومهمة جدا في
+
+312
+00:24:08,370 --> 00:24:13,370
+السؤال الثالث Vaccinia virus encodes a protein
+
+313
+00:24:13,370 --> 00:24:17,450
+that binds to interleukin-1 يبقى الإرتباط مع
+
+314
+00:24:17,450 --> 00:24:22,450
+interleukin-1بينما الفيبروموفيروس encodes a
+
+315
+00:24:22,450 --> 00:24:26,790
+protein that binds tumor necrosis factor وكلاهما
+
+316
+00:24:26,790 --> 00:24:31,110
+cytokines إذا في المحصلة النهائية ال cytokines
+
+317
+00:24:31,110 --> 00:24:35,730
+فقدت قدرتها على أداء مهمتها وبالتالي استطاع
+
+318
+00:24:35,730 --> 00:24:40,510
+الفيروس أنه يحيد جهاز المناعة من خلال تقنية
+
+319
+00:24:40,510 --> 00:24:47,350
+سميناها cytokine decoys طيب الأولانية قلتاش بها
+
+320
+00:24:47,350 --> 00:24:55,870
+مال؟بيعمل هو protein بيرتبط بالـ cytokines
+
+321
+00:24:55,870 --> 00:25:02,370
+فالتانية حاجة أغرب فالتانية حاجة ممتازة جدا الـ
+
+322
+00:25:02,370 --> 00:25:05,410
+virally infected cell عشان تعين عن نفسها لجهاز
+
+323
+00:25:05,410 --> 00:25:11,250
+المناعة تمام بتنتج class I MHC class I MHC اللي هو
+
+324
+00:25:11,250 --> 00:25:16,570
+ال major host compatibility complex طب الفيروس دخل
+
+325
+00:25:16,570 --> 00:25:21,360
+الخليةإيش بقول؟ بقول كمان شويه هذه الخلية بتبدأ
+
+326
+00:25:21,360 --> 00:25:25,340
+تطلق اللي هو صفرات الإنظار، إيش صفرات الإنظار؟
+
+327
+00:25:25,340 --> 00:25:30,820
+إنها تطلق ال class I MHC فبتروح تنتج بروتينات
+
+328
+00:25:30,820 --> 00:25:36,520
+بتعمل inhibition لل synthesis of class I MHC بتصير
+
+329
+00:25:36,520 --> 00:25:39,760
+ال virally infected cell و ال non-virally infected
+
+330
+00:25:39,760 --> 00:25:43,560
+cell نفس الشيء لما ال cytotoxic T cell تمرة عليهم
+
+331
+00:25:43,560 --> 00:25:48,640
+بتجري تتميز بينهميبجى فيها virus infected cell لكن
+
+332
+00:25:48,640 --> 00:25:53,500
+جهاز منها غير قادر على اكتشافها لماذا؟ لأنها لم
+
+333
+00:25:53,500 --> 00:25:58,940
+تنتج class 1 MHC ما الذي منها من إنتاج class 1 MHC
+
+334
+00:25:58,940 --> 00:26:05,120
+هو ال virus itself وهذا بيسموه virus kinds يبجى
+
+335
+00:26:05,120 --> 00:26:11,040
+المركبات اللي بتمنعتكوين شيء في الخلايا بنسميها
+
+336
+00:26:11,040 --> 00:26:16,200
+Virokines، إذا Virokines وCytokine Decay في اللوحة
+
+337
+00:26:16,200 --> 00:26:21,500
+السابقةهي نفس التعبير انه كيف انه الخلايا بتتواصل
+
+338
+00:26:21,500 --> 00:26:25,000
+مع بعضها بـ cytokines زي Interleukin-12 أو
+
+339
+00:26:25,000 --> 00:26:29,940
+Interferon Gamma ال viruses ممكن تعمل interference
+
+340
+00:26:29,940 --> 00:26:36,020
+ما بين هذه الخلايا وبعضها لبعض من خلال منع نشاط
+
+341
+00:26:36,020 --> 00:26:38,920
+اللي هو ال cytokines اللي احنا حكينا عنه قبل قليل
+
+342
+00:26:43,290 --> 00:26:47,410
+من النقاط المهمة اللي بتخلي جهاز الملعقة يفشل بعض
+
+343
+00:26:47,410 --> 00:26:52,390
+الأحيان في مكافحة الفيروس هو أن الفيروس يلو
+
+344
+00:26:52,390 --> 00:26:58,590
+Serotypes مختلف ميت Serotype من فيروس ال common
+
+345
+00:26:58,590 --> 00:27:02,590
+coldالرشح يعني تتأملوش انكوا فيهم الآن و تقولوا
+
+346
+00:27:02,590 --> 00:27:08,010
+انا خلصنا المية المية مرة تبعوننا و مش هنصب بعدين
+
+347
+00:27:08,010 --> 00:27:12,470
+من مين بال common cold واضح ان ال common cold هو
+
+348
+00:27:12,470 --> 00:27:17,730
+عبارة عن يعني كتلة من النشاط في تغيير ال antigen
+
+349
+00:27:17,730 --> 00:27:22,410
+تبعته وبالتالي لديه مقدرة على ان يدخل كل مرة ب
+
+350
+00:27:22,410 --> 00:27:25,350
+antigen جديد لن يتعرف عليه جهاز المناع
+
+351
+00:27:28,200 --> 00:27:30,540
+اخدنا مثال احنا ميزن من ال common cold اكتر من من
+
+352
+00:27:30,540 --> 00:27:36,940
+من مئة zero type ال influenza كذلك القمر لكن هذه
+
+353
+00:27:36,940 --> 00:27:43,180
+ليست سمة لكل الفيروسات مثلا ال small box اللي تم
+
+354
+00:27:43,180 --> 00:27:46,500
+القضاء عليه من خلال ال vaccination ليس له الا zero
+
+355
+00:27:46,500 --> 00:27:52,600
+type واحدالـ Hepatitis C و الـ AIDS اللي هم
+
+356
+00:27:52,600 --> 00:27:57,280
+Serotypes متعددة وهذا السبب هو السبب الرئيسي في
+
+357
+00:27:57,280 --> 00:28:02,140
+عدم قدرتنا على إنتاج Vaccine لهذه الأمراض، اللي هي
+
+358
+00:28:02,140 --> 00:28:08,840
+الـ Hepatitis C و الـ HIV لكن في المقابل الـ
+
+359
+00:28:08,840 --> 00:28:13,140
+Rubella Virus اللي هو الـ German Missileالميسل
+
+360
+00:28:13,140 --> 00:28:17,980
+فايروس الفارسيل ريزوستر فايروس والريبز فايروس كلهم
+
+361
+00:28:17,980 --> 00:28:23,280
+لهم فقط one zero type لذلك ال vaccination ضد هذه
+
+362
+00:28:23,280 --> 00:28:27,180
+الأمراض استطاعت بالفعل خفض هذه الأمراض تقريبا إلى
+
+363
+00:28:27,180 --> 00:28:31,600
+الصفر يبقى لما يكون one zero type بيكون صعب الجهاز
+
+364
+00:28:31,600 --> 00:28:34,900
+الملعق انه يتعامل معه لكن لما يكون different zero
+
+365
+00:28:34,900 --> 00:28:39,580
+type بيكون صعب جداالـ Polio virus بيكون له few
+
+366
+00:28:39,580 --> 00:28:43,460
+serotypes يبقى فيه many serotypes فيه single
+
+367
+00:28:43,460 --> 00:28:49,380
+serotype و فيه few serotypes نيجي
+
+368
+00:28:49,380 --> 00:28:52,200
+لل concept اللي بتعلق بال persistent viral
+
+369
+00:28:52,200 --> 00:28:57,880
+infectionاحنا قلنا ان معظم الحالات في ال viral
+
+370
+00:28:57,880 --> 00:29:01,840
+infection تبدأ ب incubation period, prodromal
+
+371
+00:29:01,840 --> 00:29:05,560
+period و specific illness period و recovery period
+
+372
+00:29:05,560 --> 00:29:11,160
+تمام؟ بعدين ال recovery قلنا هذا النسبة الأعظم من
+
+373
+00:29:11,160 --> 00:29:14,920
+ال viral infection لكن هناك بعض الحالات بيصير فيها
+
+374
+00:29:14,920 --> 00:29:20,030
+bear resistanceالان ما الذي يجعل بعض الفيروسات
+
+375
+00:29:20,030 --> 00:29:24,130
+قادرة على التعمل بـ resistance في .. في .. اما في
+
+376
+00:29:24,130 --> 00:29:31,160
+كل المرضى او في بعض المرضى؟من ضمن القليات حوالي
+
+377
+00:29:31,160 --> 00:29:35,140
+سبع قليات مقترحة قد يمتلك الفيروس واحدة او اكثر من
+
+378
+00:29:35,140 --> 00:29:41,680
+هذه القليات مثلا ان ال integration of DNA بروفيروس
+
+379
+00:29:41,680 --> 00:29:45,900
+طبعا كلمة بروفيروس زي بروفاج لأ بروفيروس زي بروفاج
+
+380
+00:29:45,900 --> 00:29:49,940
+فاكرين لما قلنا بروفاج بيعمل integrationفي الـ
+
+381
+00:29:49,940 --> 00:29:53,560
+host cell بنسمي الخلية الـ lysogenized وبنسمي هو
+
+382
+00:29:53,560 --> 00:29:56,160
+Pro phage بس هنا في هذه الحالة هو اسمه الان ايه
+
+383
+00:29:56,160 --> 00:29:59,560
+لإنه هذا مش .. مش bacterial virus animal virus لذا
+
+384
+00:29:59,560 --> 00:30:03,800
+بنسميه Pro virus بيعمل integration اللي هو زي مين
+
+385
+00:30:03,800 --> 00:30:06,600
+زي ال aids ال aids بيعمل integration لل host DNA
+
+386
+00:30:06,600 --> 00:30:12,960
+تبقى داخل الخلية ناحية immune tolerance تخيلوا
+
+387
+00:30:12,960 --> 00:30:18,940
+جهاز المناعة يعني لم يعد يرى هذا الفيروس على إنه
+
+388
+00:30:18,940 --> 00:30:24,570
+غريبتحمله وعلى انه self على انه self يبقى صار
+
+389
+00:30:24,570 --> 00:30:29,530
+الفيروس يتكاثر داخل الجسم تمام؟ ولا يستطيع الجنس
+
+390
+00:30:29,530 --> 00:30:32,190
+الماني عنه يتعرف عليه انه ايه؟ انه غريب وبتالي
+
+391
+00:30:32,190 --> 00:30:36,050
+بيكونه أجسام مضادة فيبقى الفيروس لفترات طويلة
+
+392
+00:30:37,370 --> 00:30:42,110
+Formation of Antibody or Virus Antibody Complexes
+
+393
+00:30:42,110 --> 00:30:47,110
+لسه ذكرناها قبل قليل هنا تكون تراكيب معقدة أو
+
+394
+00:30:47,110 --> 00:30:51,890
+ارتباط معقدة من ال Antibody و ال virus itself إما
+
+395
+00:30:51,890 --> 00:30:59,530
+ال Antibody و ال virus بيبقوا لفترة طويلة في أماكن
+
+396
+00:30:59,530 --> 00:31:03,130
+بعيدة عن جهاز المناها كما سنرى في رقم أربع
+
+397
+00:31:03,130 --> 00:31:08,100
+Location with an immunologically shelteredالدماغ
+
+398
+00:31:08,100 --> 00:31:14,840
+عشانه حساس ومهم ولا مجال للخطأ فيه، بعيد عن مين؟
+
+399
+00:31:14,840 --> 00:31:20,710
+عن عبث جهاز المناعة المتهورتمام؟ جهاز المناعة انا
+
+400
+00:31:20,710 --> 00:31:23,950
+شفته بتهور كتير، اذا راح على الكبت بدمره، اذا راح
+
+401
+00:31:23,950 --> 00:31:27,570
+على كده بدمره، طبعا انا مسموح على الدم، بس الان
+
+402
+00:31:27,570 --> 00:31:31,930
+الدماغ يعني off limit، وصول جهاز المناعة على
+
+403
+00:31:31,930 --> 00:31:35,030
+الدماغ بيكون قليل جدا، وبتالي لو الفيروس دخل
+
+404
+00:31:35,030 --> 00:31:39,330
+المنطقة هناك، هيكون صعب على جهاز المناعة انه يتابع
+
+405
+00:31:39,330 --> 00:31:44,660
+هذا الفيروسرقم خامسة ال .. ال .. ال rapid
+
+406
+00:31:44,660 --> 00:31:48,980
+antigenic variation وهي المقدرة السريعة للفيروسات
+
+407
+00:31:48,980 --> 00:31:53,900
+على تغيير الانتجينات الخاصة بها في كمان طريقة حلوة
+
+408
+00:31:53,900 --> 00:31:57,320
+اللي هي ال spread from cell to cell without extra
+
+409
+00:31:57,320 --> 00:32:03,720
+cellular existence يعني بيطلع من خلية إلى خلية
+
+410
+00:32:03,720 --> 00:32:07,760
+أخرى الفيروس دون ما الحاجة إلى الخروج إلى خارج
+
+411
+00:32:07,760 --> 00:32:11,700
+الخلية وهذا شفناها على تكرة في البكتيريا تمام؟
+
+412
+00:32:12,420 --> 00:32:17,440
+وشوفناها في مثال لما وينكوا الـ multinucleated
+
+413
+00:32:17,440 --> 00:32:22,640
+giant cellهو الفيروس أذاب الـ membrane اللي بينه
+
+414
+00:32:22,640 --> 00:32:24,900
+وبين الخلية التانية وبالتالي صارت الخلية التانية
+
+415
+00:32:24,900 --> 00:32:28,520
+اللي بدنيها هو صارت مولود الدمين الدمين تبعه فكون
+
+416
+00:32:28,520 --> 00:32:32,200
+خلية كبيرة دون اما الخروج إلى خارج ال .. وهذا
+
+417
+00:32:32,200 --> 00:32:34,940
+قلنالكوا احنا ال .. ال .. ال .. ال .. ال ..
+
+418
+00:32:34,940 --> 00:32:39,360
+باستعملوه اليهود في الاشتيحات في جنين وفي جباليا
+
+419
+00:32:39,360 --> 00:32:42,120
+عملوا كانوا يدخلوا بدا عشان ما يطلعوش على الشارع
+
+420
+00:32:42,120 --> 00:32:45,960
+كانوا يدخلوا من بيت إلى بيت حتى يتخطوا اللي هو
+
+421
+00:32:45,960 --> 00:32:47,940
+المقاومين اللي موجودين في الشوارع
+
+422
+00:32:50,860 --> 00:32:57,080
+رقم سبعة احنا قلنا انه في رقم جداش رقم اربعة
+
+423
+00:32:57,080 --> 00:33:02,640
+location with an immunological shelter يعني جهاز
+
+424
+00:33:02,640 --> 00:33:05,880
+المناعة مش قادر يصلي المكان هذا لكن تخيلوا رقم
+
+425
+00:33:05,880 --> 00:33:11,110
+سبعة ان المريض اصلا ليس لديه مناعة من اصلافسواء
+
+426
+00:33:11,110 --> 00:33:15,010
+كان الفيروس في منطقة sheltered ولا مش sheltered لن
+
+427
+00:33:15,010 --> 00:33:19,570
+يستطيع أنه يجهز المناع يتخلص منه، إذا حوالي سبع
+
+428
+00:33:19,570 --> 00:33:25,910
+نقاط يمكن أن تفسرنا كيفية بقاء الفيروسات لفترات
+
+429
+00:33:25,910 --> 00:33:27,150
+طويلة في المرض
+
+430
+00:33:34,490 --> 00:33:37,950
+غالبا بسبب الفيروس نفسه يعني الفيروس بيكون ال
+
+431
+00:33:37,950 --> 00:33:41,650
+antigenات تبعته قريبة جدا من antigenات الجسم اللي
+
+432
+00:33:41,650 --> 00:33:46,350
+بتعرف عليه انه non self .. non self عفوا self يعني
+
+433
+00:33:46,350 --> 00:33:50,630
+وكان جزء من مين من ال immune system الآن فينا
+
+434
+00:33:50,630 --> 00:33:57,290
+الاستكمال للحديث ثلاث أنواع من ال persistent viral
+
+435
+00:33:57,290 --> 00:34:03,730
+infection والتلاتة خطرينلكن خطورتهم مرتبطة برضه
+
+436
+00:34:03,730 --> 00:34:08,510
+بنوع ال .. ال virus اللي بسببهم فينا chronic
+
+437
+00:34:08,510 --> 00:34:12,690
+carrier infection كلمة chronic carrier يعني حامل
+
+438
+00:34:12,690 --> 00:34:20,350
+بشكل مزمن تمام؟ latent infection زي مين؟herpes
+
+439
+00:34:20,350 --> 00:34:24,890
+similics type 1 وزي حاجة تانية varicella zoster
+
+440
+00:34:24,890 --> 00:34:29,510
+كلكم الآن لديكم قنابل موقوطة في أجسامكم لما
+
+441
+00:34:29,510 --> 00:34:34,070
+انصبتوا وانتوا صغار بمين؟ بال chicken box ممكن في
+
+442
+00:34:34,070 --> 00:34:37,130
+لحظة من اللحظات من الأمر لو دي اتنين انا انخفض هذا
+
+443
+00:34:37,130 --> 00:34:41,670
+الفيروس نفسه موجود الآن تمام؟ يعمله يصيرله
+
+444
+00:34:41,670 --> 00:34:44,130
+activation مش من مصدر خارجي يصيرله activation
+
+445
+00:34:44,130 --> 00:34:49,350
+ويكون انه اللي هو ال zoster او الحزامرقم تلاتة
+
+446
+00:34:49,350 --> 00:34:53,550
+اللي هي ال slow virus infection و ال slow virus
+
+447
+00:34:53,550 --> 00:34:56,010
+infection اللي نشوف انها مثل عليها اللي هو ال HIV
+
+448
+00:34:56,010 --> 00:35:02,690
+a chronic carrier infection some patients who have
+
+449
+00:35:02,690 --> 00:35:05,390
+been infected with certain viruses continue to
+
+450
+00:35:05,390 --> 00:35:09,290
+produce significant amount of the virus for long
+
+451
+00:35:09,290 --> 00:35:14,250
+periods ماذا تعني هذه الجملة؟تعني أن الأشخاص الذين
+
+452
+00:35:14,250 --> 00:35:19,050
+أصيبوا بأنواع معينة من الفيروسات يمكن أن ينتجوا
+
+453
+00:35:19,050 --> 00:35:24,350
+كلمة ينتجوا يعني يفرزوا، تمام؟ يعني هم أنفسهم مصدر
+
+454
+00:35:24,350 --> 00:35:28,990
+عدوى، مصدر لهذا الفيروس، they produce significant
+
+455
+00:35:28,990 --> 00:35:33,310
+amount of the virus for long periods، فتلي فترات
+
+456
+00:35:33,310 --> 00:35:39,320
+طويلة جداهذه ال .. ال .. ال .. ال .. ال stage أو
+
+457
+00:35:39,320 --> 00:35:41,960
+ال state اللي بيسمينها chronic carrier infection
+
+458
+00:35:41,960 --> 00:35:49,130
+ممكن تمتج عنمرض صار acute يعني ظهر أعراضه عند
+
+459
+00:35:49,130 --> 00:35:53,090
+الإنسان ثم تحول إلى اللي هو ال chronic carrier
+
+460
+00:35:53,090 --> 00:35:56,570
+state او من البداية asymptomatic ايش يعني
+
+461
+00:35:56,570 --> 00:36:00,650
+asymptomatic؟ يعني ماكانش في عنده أعراض وضاله يعني
+
+462
+00:36:00,650 --> 00:36:05,590
+الفيروس موجود وبيتكاثر وبينتجه لكن هو نفسه ليس
+
+463
+00:36:05,590 --> 00:36:11,760
+لديه أي أعراض، إذا قد ينتج منالبداية أنه مافيه
+
+464
+00:36:11,760 --> 00:36:16,820
+أعراض أو قد يكون هناك أعراض حادة ثم تختفي ويتحول
+
+465
+00:36:16,820 --> 00:36:20,500
+المريض إلى ما يسمى بالـ Chronic Carrier Infection
+
+466
+00:36:21,460 --> 00:36:24,980
+من الأمثلة المهمة جدا أو الشهيرة اللي هو chronic
+
+467
+00:36:24,980 --> 00:36:28,880
+hepatitis اللي بتحدث في Hepatitis B و Hepatitis C
+
+468
+00:36:28,880 --> 00:36:31,840
+وفيه كمان شغل اللي ينهي تربيلا فيروس
+
+469
+00:36:31,840 --> 00:36:36,160
+وCytomegalovirus in which carriers can produce
+
+470
+00:36:36,160 --> 00:36:42,900
+virus for years تخيلوا لأن ما عنده اي مشكلةهو نفسه
+
+471
+00:36:42,900 --> 00:36:48,820
+normal طبيعي ما عنده أي أعراض لكن هو carrier حامل
+
+472
+00:36:48,820 --> 00:36:54,280
+وينتج ال virus وفي هذه الحالة هو إنسان معدي إنسان
+
+473
+00:36:54,280 --> 00:37:00,160
+أو شخص معدي إيش الأمثلة اللي قالوها تانية اللي
+
+474
+00:37:00,160 --> 00:37:04,540
+ذكرناهم هنا Hepatitis B Hepatitis C Neonatal
+
+475
+00:37:04,540 --> 00:37:07,500
+Rubella وCytomegalovirus
+
+476
+00:37:10,720 --> 00:37:15,160
+الـ Latent Infection احنا يمكن صرنا خبرة بكلمة
+
+477
+00:37:15,160 --> 00:37:19,700
+Herpes Simplex Type I بإن هو الأساس في الموضوع
+
+478
+00:37:19,700 --> 00:37:25,220
+اللي هو ال .. اللي .. اللي تنسي best illustrated
+
+479
+00:37:25,220 --> 00:37:29,800
+by herpes group the patient recovers from initial
+
+480
+00:37:29,800 --> 00:37:33,780
+infection and virus production stops مافيش إنتاج
+
+481
+00:37:33,780 --> 00:37:39,110
+فيروسطبنا شوفينا تماما مافي اي اعراض مافي اي signs
+
+482
+00:37:39,110 --> 00:37:46,210
+لكن ال virus كام ان لا يتكاثر في الأولى اللي هي ال
+
+483
+00:37:46,210 --> 00:37:51,030
+chronic carrier كان بتكاثر هم اللي هنا اذا خفنا ال
+
+484
+00:37:51,030 --> 00:37:56,690
+virus مابيتكاثر بصير فين دولة تنسيكمون اذا اجا ال
+
+485
+00:37:56,690 --> 00:37:59,810
+inciting factor و ال inciting factor قد يكون
+
+486
+00:37:59,810 --> 00:38:03,490
+مجموعة من الأسباب نعرف بعضها و بعضها لا نعرفها
+
+487
+00:38:03,490 --> 00:38:06,970
+بالضبط لكنفي الآخر إذا إيجا ال inciting factor
+
+488
+00:38:06,970 --> 00:38:11,750
+بيصير فيه activation و multiplication لهذا ال
+
+489
+00:38:11,750 --> 00:38:18,350
+virus و طبعا هذا الظهور البثارات النتجة عن الاتهاب
+
+490
+00:38:18,350 --> 00:38:23,110
+مرتبطة الفيروس وين مختبئ في أي nerve في أي nerve
+
+491
+00:38:23,110 --> 00:38:28,430
+cells ال
+
+492
+00:38:28,430 --> 00:38:36,140
+slow virus infection و كلمة slowالحقيقة يعني مصطلح
+
+493
+00:38:36,140 --> 00:38:36,780
+فاضفاض
+
+494
+00:38:39,520 --> 00:38:46,740
+و fast كلمة مصطلح فاضلة سريعا احنا بالنسبة لنا في
+
+495
+00:38:46,740 --> 00:38:51,600
+العلوم مابنقبلش بهذه المصطلحات بدون تحديد سرعات
+
+496
+00:38:51,600 --> 00:38:55,260
+لما نقول slow و نقول fast صح ولا لأ بس هو ال term
+
+497
+00:38:55,260 --> 00:38:58,640
+هي درجة على ان ال viral infection فترة ال
+
+498
+00:38:58,640 --> 00:39:01,700
+inclusion تبعتها العادية قصيرة و فترة الاعراض
+
+499
+00:39:01,700 --> 00:39:06,020
+الحادة ايضا كمان قصيرة و ال recovery قصير فهذه ال
+
+500
+00:39:06,020 --> 00:39:09,860
+period هي ال period ال normalاللي أطول من هيك
+
+501
+00:39:09,860 --> 00:39:15,040
+سمناها slow بشكل عام refers to the prolonged
+
+502
+00:39:15,040 --> 00:39:18,300
+period between the initial infection and the onset
+
+503
+00:39:18,300 --> 00:39:22,760
+of the disease من بداية المرض إلى ظهور العرض which
+
+504
+00:39:22,760 --> 00:39:27,780
+is usually measured in years years يعني نتكلم عن
+
+505
+00:39:27,780 --> 00:39:32,180
+سنوات وبالفعل كلمة slow هنا تمشي عليها لأنه احنا
+
+506
+00:39:32,180 --> 00:39:34,920
+اتعودنا على ان ال viral infection هي فترة قصيرة
+
+507
+00:39:34,920 --> 00:39:41,410
+ايام او بحد اقصى اقل من شهرIt is not that virus
+
+508
+00:39:41,410 --> 00:39:47,630
+growth is slow ليس أن عملية نمو الفيروسات البطيئة
+
+509
+00:39:47,630 --> 00:39:51,070
+وانما ال incubation period و ال progression في ال
+
+510
+00:39:51,070 --> 00:39:56,870
+disease هو اللي طويل إذا ليس له علاقة بسرعة تكاثر
+
+511
+00:39:56,870 --> 00:40:00,570
+الفيروس يعني احنا كنا نقول في البكتيريا ال
+
+512
+00:40:00,570 --> 00:40:03,810
+mycobacterium tuberculosis is a slow growing
+
+513
+00:40:03,810 --> 00:40:08,030
+organism لأن ال duplication time تبقى عشرين دقيقة
+
+514
+00:40:08,310 --> 00:40:12,730
+انا هنا كلمة slow لاتنطق على نفس المعنى وانما ال
+
+515
+00:40:12,730 --> 00:40:16,250
+disease progression هو نفسه بطيق بينما ال virus
+
+516
+00:40:16,250 --> 00:40:21,010
+replication هو عادى two of these diseases are
+
+517
+00:40:21,010 --> 00:40:25,170
+caused by the conventional viruses namely sub
+
+518
+00:40:25,170 --> 00:40:30,970
+acute sclerosing panencephalitis وكلمة pan يعني كل
+
+519
+00:40:30,970 --> 00:40:34,870
+الدماغ panencephalitis which follows several years
+
+520
+00:40:34,870 --> 00:40:39,130
+after measles virus infectionتخيلوا الفيروس
+
+521
+00:40:39,130 --> 00:40:44,510
+الانسان أصيب بالحصبة تمام؟ وتقريبا شوف يا منها
+
+522
+00:40:44,510 --> 00:40:50,750
+الان الفيروس هنا في هذه الحالة ما اختفى من الجسم
+
+523
+00:40:50,750 --> 00:40:59,770
+ولا كمان تمام؟ وتكاثر لكن تكاثره تأثيره على الدماغ
+
+524
+00:40:59,770 --> 00:41:04,710
+استمر سنوات حتى يظهر أعراض هذا المرض اللي سمينها
+
+525
+00:41:04,710 --> 00:41:08,980
+panencephalitisالمثال التاني حاسس انها progressive
+
+526
+00:41:08,980 --> 00:41:13,880
+multifocal leukoencephalopathy او PML واللي بسببه
+
+527
+00:41:13,880 --> 00:41:19,960
+ال GC Virus اذا اتنين فيروسات مثلين رائعين على
+
+528
+00:41:19,960 --> 00:41:25,360
+slow فيروس الان المثال الثالث ليس له علاقة
+
+529
+00:41:25,360 --> 00:41:31,080
+بالفيروساتلكن ضمن مين؟ ضمن ال slow infections يبقى
+
+530
+00:41:31,080 --> 00:41:35,580
+ممكن ألغمين هنا في العنوان اللي هو كلمة virus أو
+
+531
+00:41:35,580 --> 00:41:41,520
+بنخليها احتراما لل virus لكن القادم الجديد على
+
+532
+00:41:41,520 --> 00:41:47,220
+العلم الطبي اللي هو ال prions تمام لم يجي له مكانا
+
+533
+00:41:47,220 --> 00:41:51,780
+منفصلا بعد فعطوهم ضمن مين؟ يعني ال virology مؤقتا
+
+534
+00:41:51,780 --> 00:41:55,500
+العلم اللي جيهم إخوة نين و نفصلهم و نوصلهم علم خاص
+
+535
+00:41:55,500 --> 00:42:00,870
+بيهمبس هم بريونز و ال بريونز هم ليسوا فيروس بريونز
+
+536
+00:42:00,870 --> 00:42:08,110
+هم بروتين هم انفكشفز زي مثلا كروتزفيرد جايكوب دزيز
+
+537
+00:42:08,110 --> 00:42:14,110
+اللي هو يقابل جنون البقر هو جهد جنون البشر و كورو
+
+538
+00:42:14,110 --> 00:42:20,690
+كورو برضه مابصيب الدماغ و بسببه ال بريونز كلا هما
+
+539
+00:42:21,900 --> 00:42:25,580
+كل المرضين بتسببهم هو قولنا ال unconventional كلمة
+
+540
+00:42:25,580 --> 00:42:29,040
+ال unconventional يعني ايه يعني غير تقليديين اللي
+
+541
+00:42:29,040 --> 00:42:37,620
+هم ال prions ابداك احنا بنكون خلينا نقول مرنا على
+
+542
+00:42:37,620 --> 00:42:41,120
+مجموعة من المعلومات بتحاول نخصهم بشكل سريع قبل
+
+543
+00:42:41,120 --> 00:42:44,160
+انهاء المحاضرة ان شاء اللههذه المعلومات بتتكلم عن
+
+544
+00:42:44,160 --> 00:42:50,080
+ال pathogenesis في ال viral infection واستطعنا أن
+
+545
+00:42:50,080 --> 00:42:53,140
+نصورهما في مكانين، المكان الأول في الخلية على
+
+546
+00:42:53,140 --> 00:42:55,920
+مستوى الخلية والمكان التاني على مستوى ال host
+
+547
+00:42:55,920 --> 00:42:59,620
+وقلنا إنها infection ومثلا infection بتنتقل من إلى
+
+548
+00:42:59,620 --> 00:43:02,740
+يتجه في portal of interest واتكلمنا عن ال portal
+
+549
+00:43:02,740 --> 00:43:07,620
+of interest واخدنا نماذج على كيفية انتقال بعض
+
+550
+00:43:07,620 --> 00:43:11,850
+الميكروبات أو بعض الفيروسات من إلىبعدين الجزء
+
+551
+00:43:11,850 --> 00:43:16,210
+التاني كان من المحاضرات اللي بقتنا متعلق بكيفية
+
+552
+00:43:16,210 --> 00:43:21,310
+خداع الفيروس لجهاز المناعة واخدنا أنثى للحقيقة
+
+553
+00:43:21,310 --> 00:43:24,650
+كبيرة اخدنا ال cytokines ال decoy اخدنا ال
+
+554
+00:43:24,650 --> 00:43:29,950
+virokines اخدنا ال killing قتل مباشر لقل اخدنا انه
+
+555
+00:43:29,950 --> 00:43:33,730
+كمان جهاز المناعة تبعنا للأسف يعني بعض الأحيان هو
+
+556
+00:43:33,730 --> 00:43:39,930
+اللي بكونالو دور في تضرر الناجم عن الـ Virally
+
+557
+00:43:39,930 --> 00:43:43,370
+Infected Cell من خلال مهاجمة هذه الخلايا و بعدين
+
+558
+00:43:43,370 --> 00:43:50,690
+انتقلنا الى جزئيات متعلقة بتصنيفات الـ Persistent
+
+559
+00:43:50,690 --> 00:43:53,610
+Infection اللي هي قلنا عنها Chronic Carrier State
+
+560
+00:43:53,610 --> 00:43:57,850
+و Latent Infection و الأخيرة الـ Slow Virus مرة
+
+561
+00:43:57,850 --> 00:44:02,880
+أخرى أود أن أؤكد عليكم أهمية حفظالـMedically
+
+562
+00:44:02,880 --> 00:44:05,380
+Important Viruses Classification of Medically
+
+563
+00:44:05,380 --> 00:44:08,760
+Important Viruses هذا ال chapter رجزوا عليه بشكل
+
+564
+00:44:08,760 --> 00:44:12,600
+خاص في الفترة هذه لأنه بيلزم المرة الجاية مش هناخد
+
+565
+00:44:12,600 --> 00:44:15,420
+ال immunology هناخد ال laboratory diagnosis لل
+
+566
+00:44:15,420 --> 00:44:18,180
+viral infection بنكمل المرة الجاية ان شاء الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/S8YyMBAkVeI_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/S8YyMBAkVeI_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..33f0c3356f6b97b1b08420be6f90f670bc0c4b5d
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/S8YyMBAkVeI_raw.json
@@ -0,0 +1 @@
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"word": " بيقعد", "probability": 0.64361572265625}, {"start": 1465.67, "end": 1466.15, "word": " بيظهر", "probability": 0.86728515625}, {"start": 1466.15, "end": 1466.31, "word": " من", "probability": 0.94091796875}, {"start": 1466.31, "end": 1466.71, "word": " جديد", "probability": 0.98974609375}, {"start": 1466.71, "end": 1467.11, "word": " و", "probability": 0.31640625}, {"start": 1467.11, "end": 1467.49, "word": " أكبر", "probability": 0.8880208333333334}, {"start": 1467.49, "end": 1468.15, "word": " دليل", "probability": 0.9775390625}, {"start": 1468.15, "end": 1468.33, "word": " على", "probability": 0.84326171875}, {"start": 1468.33, "end": 1468.67, "word": " ذلك", "probability": 0.988037109375}, {"start": 1468.67, "end": 1469.05, "word": " ما", "probability": 0.826171875}, {"start": 1469.05, "end": 1469.63, "word": " نراه", "probability": 0.9842122395833334}, {"start": 1469.63, "end": 1470.35, "word": " من", "probability": 0.93896484375}, {"start": 1470.35, "end": 1471.31, 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diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/XeQECqyHJNs_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/XeQECqyHJNs_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..5fbe26d6e1f1afac39dd299ebd2e077fd657d8ce
--- /dev/null
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@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3427, "start": 21.01, "end": 34.27, "text": "طيب بسم الله الرحمن الرحيم ما زلنا في ال DNA envelope viruses و بنتكلم عن ثلاثة مجموعات، المجموعة الأولى كانت herpes virus family، التانية ال box viruses والتالتة هيبادنة virus", "tokens": [9566, 1829, 3555, 4724, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 19446, 30767, 1211, 8315, 8978, 2423, 8272, 19989, 21785, 4032, 4724, 29399, 4117, 19528, 18871, 38637, 1211, 5718, 104, 3660, 3714, 7435, 2304, 45367, 9307, 12399, 9673, 7435, 2304, 2407, 27884, 16247, 12610, 7578, 25961, 2655, 720, 5190, 5752, 1605, 12399, 16712, 7649, 10632, 2423, 2424, 21785, 16070, 2655, 6027, 2655, 3660, 39896, 3555, 18513, 1863, 3660, 5752], "avg_logprob": -0.2469190241585315, "compression_ratio": 1.4918032786885247, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 21.01, "end": 21.27, "word": "طيب", "probability": 0.7779134114583334}, {"start": 21.27, "end": 21.45, "word": " بسم", "probability": 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"end": 221.5, "word": "-specific،", "probability": 0.6255696614583334}, {"start": 221.5, "end": 222.02, "word": " والحقيقة", "probability": 0.9351806640625}, {"start": 222.02, "end": 222.32, "word": " أن", "probability": 0.66943359375}, {"start": 222.32, "end": 223.34, "word": " الـheterophil", "probability": 0.6116536458333334}, {"start": 223.34, "end": 223.86, "word": " antibody", "probability": 0.73193359375}, {"start": 223.86, "end": 224.14, "word": " can", "probability": 0.50048828125}, {"start": 224.14, "end": 224.28, "word": " be", "probability": 0.93505859375}, {"start": 224.28, "end": 224.6, "word": " found", "probability": 0.90087890625}, {"start": 224.6, "end": 224.78, "word": " in", "probability": 0.958984375}, {"start": 224.78, "end": 225.02, "word": " other", "probability": 0.87646484375}, {"start": 225.02, "end": 225.72, "word": " diseases،", "probability": 0.69287109375}, {"start": 225.72, "end": 225.84, "word": " ومن", "probability": 0.962158203125}, {"start": 225.84, 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{"id": 45, "seek": 99005, "start": 962.57, "end": 990.05, "text": "يعني تخيلوا أنه أصلا احنا ماكناش عارفين عن اللي ابشتين بار فيروس غير سنة ألف و تسعمية و أربعة و ستين و هاد المعهد الفنانات اللي اتعرفين منهن من إنه ال .. ال lymphoma cells اللي نمناها في ال cell culture تمام؟ أظهرتنا مين؟ فيروس اسمه ابشتين بار سمناه ابشتين بار فيروس يبجا السلطان كان معروف جاب من مين؟ جاب للفيروس و بعدين علفنا الفيروس من خلال هذا السلطان", "tokens": [40228, 22653, 6055, 9778, 26895, 14407, 14739, 3224, 5551, 9381, 15040, 1975, 5016, 8315, 19446, 19452, 33599, 6225, 9640, 5172, 9957, 18871, 13672, 1829, 48127, 8592, 2655, 9957, 4724, 9640, 8978, 32887, 3794, 32771, 13546, 8608, 1863, 3660, 5551, 46538, 4032, 6055, 3794, 25957, 10632, 4032, 5551, 25513, 27884, 4032, 8608, 2655, 9957, 4032, 8032, 18513, 9673, 3615, 3224, 3215, 27188, 1863, 7649, 9307, 13672, 1829, 1975, 2655, 3615, 28480, 9957, 9154, 3224, 1863, 9154, 36145, 3224, 2423, 4386, 2423, 31070, 6440, 5438, 13672, 1829, 8717, 2304, 8315, 11296, 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"probability": 0.760498046875}, {"start": 2510.19, "end": 2510.39, "word": " هو", "probability": 0.65771484375}, {"start": 2510.39, "end": 2512.91, "word": " immunoglobulin", "probability": 0.9249267578125}, {"start": 2512.91, "end": 2513.05, "word": " اللي", "probability": 0.775146484375}, {"start": 2513.05, "end": 2513.15, "word": " هي", "probability": 0.77978515625}, {"start": 2513.15, "end": 2513.25, "word": " ال", "probability": 0.6962890625}, {"start": 2513.25, "end": 2513.75, "word": " VIG", "probability": 0.687255859375}, {"start": 2513.75, "end": 2513.93, "word": " اللي", "probability": 0.9560546875}, {"start": 2513.93, "end": 2514.37, "word": " درسناها", "probability": 0.92373046875}, {"start": 2514.37, "end": 2514.47, "word": " من", "probability": 0.71435546875}, {"start": 2514.47, "end": 2514.65, "word": " وين", "probability": 0.899169921875}, {"start": 2514.65, "end": 2515.27, "word": " درسناها", "probability": 0.9734375}, {"start": 2515.27, "end": 2515.87, "word": " في", "probability": 0.9443359375}, {"start": 2515.87, "end": 2516.43, "word": " ال", "probability": 0.98583984375}, {"start": 2516.43, "end": 2516.87, "word": " viral", "probability": 0.818359375}, {"start": 2516.87, "end": 2517.79, "word": " vaccines", "probability": 0.89111328125}, {"start": 2517.79, "end": 2518.43, "word": " عشان", "probability": 0.9742838541666666}, {"start": 2518.43, "end": 2518.97, "word": " نتقلل", "probability": 0.97578125}, {"start": 2518.97, "end": 2519.13, "word": " من", "probability": 0.99267578125}, {"start": 2519.13, "end": 2519.49, "word": " هذه", "probability": 0.9267578125}, {"start": 2519.49, "end": 2520.33, "word": " الأعلاق", "probability": 0.5806884765625}, {"start": 2520.33, "end": 2520.47, "word": " يعني", "probability": 0.60791015625}, {"start": 2520.47, "end": 2520.65, "word": " هنا", "probability": 0.55859375}, {"start": 2520.65, "end": 2520.99, "word": " يبدو", "probability": 0.9207356770833334}, {"start": 2520.99, "end": 2521.11, "word": " اننا", "probability": 0.44091796875}, {"start": 2521.11, "end": 2521.19, "word": " مش", "probability": 0.9677734375}, {"start": 2521.19, "end": 2521.43, "word": " هنقدر", "probability": 0.9569091796875}, {"start": 2521.43, "end": 2521.93, "word": " نخلص", "probability": 0.9925537109375}, {"start": 2521.93, "end": 2522.45, "word": " ال", "probability": 0.69384765625}, {"start": 2522.45, "end": 2522.69, "word": " chapter", "probability": 0.96826171875}, {"start": 2522.69, "end": 2523.05, "word": " تبعنا", "probability": 0.9171142578125}, {"start": 2523.05, "end": 2523.37, "word": " هذا", "probability": 0.97119140625}, {"start": 2523.37, "end": 2524.11, "word": " فالمرة", "probability": 0.8369140625}, {"start": 2524.11, "end": 2524.35, "word": " الجاية", "probability": 0.681640625}, {"start": 2524.35, "end": 2524.49, "word": " ان", "probability": 0.857421875}, {"start": 2524.49, "end": 2524.67, "word": " شاء", "probability": 0.916259765625}, {"start": 2524.67, "end": 2524.83, "word": " الله", "probability": 0.9619140625}, {"start": 2524.83, "end": 2525.77, "word": " بنشرح", "probability": 0.9523111979166666}, {"start": 2525.77, "end": 2526.03, "word": " اللي", "probability": 0.97705078125}, {"start": 2526.03, "end": 2526.31, "word": " هو", "probability": 0.98828125}, {"start": 2526.31, "end": 2527.23, "word": " اخر", "probability": 0.724853515625}, {"start": 2527.23, "end": 2528.13, "word": " فيروس", "probability": 0.784423828125}, {"start": 2528.13, "end": 2529.01, "word": " كمقدمة", "probability": 0.9757080078125}, {"start": 2529.01, "end": 2529.71, "word": " ل", "probability": 0.88427734375}], "temperature": 1.0}, {"id": 111, "seek": 253348, "start": 2530.27, "end": 2533.49, "text": "الـ DNA Non-Enveloped Virus بإذن الله", "tokens": [6027, 39184, 8272, 8774, 12, 16257, 1388, 292, 39790, 4724, 28814, 8848, 1863, 21984], "avg_logprob": -0.47213541666666664, "compression_ratio": 0.8727272727272727, "no_speech_prob": 0.0, "words": [{"start": 2530.27, "end": 2530.85, "word": "الـ", "probability": 0.68603515625}, {"start": 2530.85, "end": 2531.27, "word": " DNA", "probability": 0.6669921875}, {"start": 2531.27, "end": 2531.65, "word": " Non", "probability": 0.16064453125}, {"start": 2531.65, "end": 2532.47, "word": "-Enveloped", "probability": 0.7982177734375}, {"start": 2532.47, "end": 2532.99, "word": " Virus", "probability": 0.7373046875}, {"start": 2532.99, "end": 2533.35, "word": " بإذن", "probability": 0.59173583984375}, {"start": 2533.35, "end": 2533.49, "word": " الله", "probability": 0.904296875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2533.831125, "duration_after_vad": 2398.5374999999913}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Y0-QuWrz92s.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Y0-QuWrz92s.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7c61d46d27f2abecb0af472e425a7c291ce1faff
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Y0-QuWrz92s.srt
@@ -0,0 +1,2403 @@
+1
+00:00:21,360 --> 00:00:26,560
+بسم الله الرحمن الرحيم نكمل إن شاء الله الـ الـ
+
+2
+00:00:26,560 --> 00:00:30,200
+RNA enveloped viruses وهنتكلم عنهم  شوية الـ
+
+3
+00:00:30,200 --> 00:00:33,360
+paramyxoviruses نسترجع بعض المعلومات اللي ذكرناها 
+
+4
+00:00:33,360 --> 00:00:37,240
+في المحاضرة السابقة عن هذه المجموعة اللي تحدثنا أنها
+
+5
+00:00:37,240 --> 00:00:40,960
+تشبه إلى حد كبير الـ orthomyxoviruses لكن في وجه
+
+6
+00:00:40,960 --> 00:00:46,560
+اختلاف رئيسي وهو عدم وجود جنوم مقطع لكن 
+
+7
+00:00:46,560 --> 00:00:49,120
+الجنوم بتاعهم بيشتركوا بينهم single
+
+8
+00:00:52,010 --> 00:00:55,450
+والثانية بيحملوا معاهم RNA dependent RNA
+
+9
+00:00:55,450 --> 00:01:00,150
+polymerase والجينوم تبعهم not infectious يعني 
+
+10
+00:01:00,150 --> 00:01:04,470
+غير معدي بيحتوي على spikes أيضا بيشبهوا الـ spikes
+
+11
+00:01:04,470 --> 00:01:09,690
+تبع الـ orthomyxoviruses لكن قد تحتوي على 
+
+12
+00:01:09,690 --> 00:01:13,550
+هيماجلوتينين ونيراميديز on one single spike وفي
+
+13
+00:01:13,550 --> 00:01:16,510
+بالإضافة إلى الهيماجلوتينين ونيراميديز حاجة
+
+14
+00:01:16,510 --> 00:01:20,510
+اسمها fusion protein وحاجة اسمها كمان hemolytic
+
+15
+00:01:20,510 --> 00:01:23,710
+activity إذا أنت مر معاك في اللي هو الـ orthomyxo
+
+16
+00:01:23,710 --> 00:01:28,640
+viruses وبنقسم احنا الفيروسات الـ الـ الـ الـ
+
+17
+00:01:28,640 --> 00:01:31,640
+الـ viridae وكلمة viridae معناها عائلة لما نسمع
+
+18
+00:01:31,640 --> 00:01:35,820
+كلمة paramyxoviridae يبقى الشق الأخير في الكلمة viridae تعني عائلة على غرار اللي
+
+19
+00:01:35,820 --> 00:01:40,740
+بتذكره في الـ bacteriology كنا نقول
+
+20
+00:01:40,740 --> 00:01:42,720
+enterobacteriaceae family micrococciaceae family
+
+21
+00:01:42,720 --> 00:01:48,300
+فالـ viridae هنا family أيضا وبتنقسم إلى ثلاثة
+
+22
+00:01:48,300 --> 00:01:52,570
+genera اللي هم الـ Paramyxovirus والموربيليفيروس
+
+23
+00:01:52,570 --> 00:01:55,810
+والنيوموفيروس الـ Paramyxovirus بيشمل الـ Mumps والـ
+
+24
+00:01:55,810 --> 00:02:00,700
+Parainfluenza وهي أبعاها أربعة سلالات من واحد
+
+25
+00:02:00,700 --> 00:02:04,040
+لأربعة والموربيليفيروس بيشمل الـ Measles virus
+
+26
+00:02:04,040 --> 00:02:08,220
+اللي هو بيسموه Rubella وبنميزه عن الربلة الربلة
+
+27
+00:02:08,220 --> 00:02:12,420
+اللي هي الـ German Measles الـ Pneumovirus من اسمه
+
+28
+00:02:12,420 --> 00:02:16,360
+بيشمل فقط اللي هو الـ Respiratory syncytial virus
+
+29
+00:02:16,360 --> 00:02:19,060
+اللي بيعمل لنا Pulmonary infection
+
+30
+00:02:19,060 --> 00:02:21,580
+اللي بيعمل لنا Pulmonary infection
+
+31
+00:02:23,990 --> 00:02:28,190
+ولما جينا طلعنا على الـ أربعة فيروسات اللي شملوا في
+
+32
+00:02:28,190 --> 00:02:33,690
+هذه المجموعة بنلاقي إن كلهم بيحتوي على Fusion
+
+33
+00:02:33,690 --> 00:02:37,990
+Protein في العمود الأخير لكن مش كلهم بيحتوي على
+
+34
+00:02:37,990 --> 00:02:40,790
+نيراميديز فقط اثنين هما الـ mumps virus والـ para
+
+35
+00:02:40,790 --> 00:02:44,030
+influenza virus والوحيد اللي مابيحتويش على
+
+36
+00:02:44,030 --> 00:02:48,010
+Hemagglutinin هو الـ respiratory syncytial virus
+
+37
+00:02:48,010 --> 00:02:51,890
+طبعا الـ respiratory syncytial virus شهرته بأنه هو
+
+38
+00:02:51,890 --> 00:02:54,770
+من اللي بيعمل syncytia اللي هي الـ multinucleated
+
+39
+00:02:54,770 --> 00:02:55,750
+giant cell
+
+40
+00:02:59,030 --> 00:03:02,390
+بدأنا بحديث عن اللي هو الـ measles virus وقلنا إنه
+
+41
+00:03:02,390 --> 00:03:05,650
+الـ الـ الـ measles هو disease of childhood
+
+42
+00:03:05,650 --> 00:03:09,130
+غالبا بيصيب أمراض أو أو هو من مرض مرض من
+
+43
+00:03:09,130 --> 00:03:14,050
+أمراض الطفولة بينتقل عبر الـ respiratory tract و
+
+44
+00:03:14,050 --> 00:03:17,850
+بسبب إنه بيسبب maculopapular rash والـ rash هنا 
+
+45
+00:03:17,850 --> 00:03:22,230
+هنا بيبدأ من الفم من الداخل من اللسان ثم إلى الوجه
+
+46
+00:03:22,230 --> 00:03:28,730
+ثم إلى باقي الجسد طبعا كان في مثل زمان بيقول ما
+
+47
+00:03:28,730 --> 00:03:34,210
+حياة إلا بعد حصبة إيش يعني؟ يعني كانوا الناس يعني
+
+48
+00:03:34,210 --> 00:03:39,250
+مدركين حجم المخاطر المحدقة بأبناءهم من اللي هو
+
+49
+00:03:39,250 --> 00:03:43,370
+المرض الحصبة وبتالي مايعتبروش إن ابنهم هيبقى على
+
+50
+00:03:43,370 --> 00:03:48,000
+قيد الحياة ويكمل المسيرة إلا إيه ده؟ نجا من مرض
+
+51
+00:03:48,000 --> 00:03:51,860
+اللي هو الحصبة دليل على إيه؟ على إنه كانت بالفعل
+
+52
+00:03:51,860 --> 00:03:57,300
+في السابق تشكل خطر كبير على الأطفال وهو worldwide
+
+53
+00:03:57,300 --> 00:04:01,300
+disease مرض يعني عالمي بيصيب كل سكان العالم
+
+54
+00:04:04,050 --> 00:04:08,370
+الجنوم بتاعه بيكسب الفيروس يعني negative sense
+
+55
+00:04:08,370 --> 00:04:13,890
+single-stranded RNA ومعه قلنا كمان مرة اللي هو الـ
+
+56
+00:04:13,890 --> 00:04:17,630
+RNA dependent RNA polymerase بيحتوي على الـ
+
+57
+00:04:17,630 --> 00:04:22,250
+measles virus على hemagglutinating activity وعلى
+
+58
+00:04:22,250 --> 00:04:26,160
+cell fusion و hemolytic activity إذا فيه إنه two
+
+59
+00:04:26,160 --> 00:04:30,260
+spikes واحد بيشمل اللي هو الـ hemagglutination
+
+60
+00:04:30,260 --> 00:04:34,100
+والثاني بيشمل two function fusion and hemolytic
+
+61
+00:04:34,100 --> 00:04:37,380
+activity it has a single serotype وهذا قلنا سر
+
+62
+00:04:37,380 --> 00:04:41,100
+نجاح إن احنا قمنا بفكسينة وإن الـ human are the
+
+63
+00:04:41,100 --> 00:04:45,680
+only natural host وهذا أيضا إضافة لماذا نجحنا في
+
+64
+00:04:45,680 --> 00:04:46,860
+إحداث الفكسينة 
+
+65
+00:04:49,710 --> 00:04:52,190
+بينتقل جميعا عبر الـ respiratory tract من خلال الـ
+
+66
+00:04:52,190 --> 00:04:56,150
+respiratory droplets الـ incubation الـ إيه؟ عفوا
+
+67
+00:04:56,150 --> 00:04:59,890
+الـ outbreaks تبعته تحدث من كل ما بين سنتين لكل
+
+68
+00:04:59,890 --> 00:05:04,670
+ثلاث سنوات ليش مش كل سنة يعني؟ لما بيتجمع عدد
+
+69
+00:05:04,670 --> 00:05:09,190
+أطفال عدد أطفال ما عندهم مش مناعة بنسميهم
+
+70
+00:05:09,190 --> 00:05:13,390
+susceptible يعني قابلين لمين؟ للإصابة طب هل هناك
+
+71
+00:05:13,390 --> 00:05:17,630
+أماكن في العالم لم يصلها الـ vaccination بشكل كافي؟
+
+72
+00:05:18,290 --> 00:05:22,550
+لكم تتخيلوا أمريكا أمريكا من الدول مش من
+
+73
+00:05:22,550 --> 00:05:26,190
+الدول هي أكثر دولة متقدمة تقنيا وصحيا ممكن في
+
+74
+00:05:26,190 --> 00:05:32,900
+على مستوى العالم لكن داخل هذه الدولة هناك عقليات
+
+75
+00:05:32,900 --> 00:05:39,560
+وأفكار تمام بيجتمعوا مع بعض مثلا مابتجوزوش من
+
+76
+00:05:39,560 --> 00:05:44,080
+خارج إطار المجموعة اللي هم معتقدات دينية معينة
+
+77
+00:05:44,080 --> 00:05:47,260
+بتعتقدوا أن الـ vaccination على سبيل المثال هو شيء
+
+78
+00:05:47,260 --> 00:05:50,540
+مش مطلوب وقد يضر أبناءهم وبتالي مابتطعموش
+
+79
+00:05:50,540 --> 00:05:54,020
+بيتحالوا على النظام الصحي بيتحالوا عليه بأي طريقة
+
+80
+00:05:54,020 --> 00:05:59,640
+مابتطعموش فكل فترة وفترة بيصير فيه انتشار أوبئة بين
+
+81
+00:05:59,640 --> 00:06:02,420
+هذه الفياترات على الرغم من أنها موجودة في دول
+
+82
+00:06:02,420 --> 00:06:06,100
+متقدمة فدعا بالك الآن في دول يعني غير متطورة أو
+
+83
+00:06:06,100 --> 00:06:10,520
+نامية أو احنا بنسميها دول العالم الثالث تعبير لطيف
+
+84
+00:06:10,520 --> 00:06:13,860
+عن التخلف اللي عاشها فيه تمام؟ لأن مافيش بعد
+
+85
+00:06:13,860 --> 00:06:19,140
+الثالث شيء فبالتالي هي الأخيرة وهذه الدول تتميز
+
+86
+00:06:19,140 --> 00:06:23,050
+بشغل ثاني إن في عندها malnutrition سوء تغذية
+
+87
+00:06:23,050 --> 00:06:26,690
+ولكن وما تتخيلوا ما يحدث الآن في إخواننا في اليمن
+
+88
+00:06:26,690 --> 00:06:30,610
+وفي سوريا يعني هناك صور يعني بتخشعوا اللي أبدا
+
+89
+00:06:30,610 --> 00:06:33,510
+تخرج من اليمن في الفترة الحالية خاصة مع اللي هو
+
+90
+00:06:33,510 --> 00:06:39,810
+الحرب وانتشار مرض أيضا الكوليرا فقر سوء تغذية
+
+91
+00:06:42,260 --> 00:06:47,280
+الخطورة الأولويات بتتغير خطورة المعنى إنه ممكن
+
+92
+00:06:47,280 --> 00:06:50,680
+الأمة ما تقدرش تتصل أصلا لمركز الرعاية الصحية عشان
+
+93
+00:06:50,680 --> 00:06:55,120
+التطعيم المولود مظبوط الأولويات بتصير للجرحى
+
+94
+00:06:55,120 --> 00:06:58,640
+والقتلى وللدفن الجثث وبتالي الأولويات بتتغير
+
+95
+00:06:58,640 --> 00:07:03,300
+فدائما وأبدا مافيش 100% coverage للـ vaccination
+
+96
+00:07:03,300 --> 00:07:09,180
+في كثير من اللي هم وبالتالي كل فترة من سنتين لثلاث
+
+97
+00:07:09,180 --> 00:07:15,420
+بيحدث outbreak في تلك المناطق واحنا اتفقنا وناقشنا
+
+98
+00:07:15,420 --> 00:07:24,180
+قبلها قضية حدوث وباء لابد أن يكون مجموع السكان
+
+99
+00:07:24,180 --> 00:07:27,400
+المطعمين
+
+100
+00:07:27,400 --> 00:07:31,290
+أو الذين لا يمتلكون مناعة ضد الميكروب وإن كان سواء
+
+101
+00:07:31,290 --> 00:07:36,230
+كان فيروس أو كان بكتيريا لازم يكون عدد كبير جدا من
+
+102
+00:07:36,230 --> 00:07:40,130
+السكان غير مطعمين واحنا بنقول إن الآن المرحلة
+
+103
+00:07:40,130 --> 00:07:43,870
+مهيئة على سبيل المثال لحدوث وباء عالمي بالجدري
+
+104
+00:07:43,870 --> 00:07:48,990
+ليش؟ لإنه توقفنا عن تطعيم ولا يرد إصابات في الوقت
+
+105
+00:07:48,990 --> 00:07:52,110
+الحالي بالجدري وبالتالي في يوم من الأيام لو قرر
+
+106
+00:07:52,110 --> 00:07:56,050
+أحد الناس أن يقوم بحرب بيولوجية أو إرهاب بيولوجي
+
+107
+00:07:56,050 --> 00:07:59,890
+وينشر الفيروسات اللي هي الآن موجودة في مختبرات
+
+108
+00:07:59,890 --> 00:08:04,620
+دولة الولايات المتحدة الأمريكية وروسيا فيحدث جائحة عالمية
+
+109
+00:08:04,620 --> 00:08:10,420
+لأن السكان الآن مؤهلين ليش مؤهلين؟ ليس لديهم مناعة
+
+110
+00:08:10,420 --> 00:08:14,840
+أو antibodies أو vaccination مسبق ضد هذا الموضوع
+
+111
+00:08:14,840 --> 00:08:20,340
+وهذا ثبت حقيقة في كل تاريخيا في كل المناطق اللي
+
+112
+00:08:20,340 --> 00:08:25,540
+انتقل إليها مرض لم يكن موجود في السابق كان يحدث
+
+113
+00:08:25,540 --> 00:08:31,120
+أوبئة devastating منها الـ measles في ألف وتمانية
+
+114
+00:08:31,120 --> 00:08:39,100
+في القرن التاسع عشر بعض السياح عرفوا Hawaii Hawaii
+
+115
+00:08:39,100 --> 00:08:44,760
+جزر حلوة وجميلة فصاروا يزوروها زوار أو سياح ولم
+
+116
+00:08:44,760 --> 00:08:47,840
+يكن السكان هناك قد عرفوا مرة بالحصبة من قبل
+
+117
+00:08:47,840 --> 00:08:52,860
+فأصبحوا مرة بالحصبة مع من؟ مع السياح فأحدث لديهم
+
+118
+00:08:52,860 --> 00:08:58,020
+لدى السكان الأصليين devastating epidemic فهذه نقطة
+
+119
+00:08:58,020 --> 00:09:00,800
+ياريت نكون منتبهين لها إنه مش معناه الحاجة إن
+
+120
+00:09:00,800 --> 00:09:05,640
+المرض بطل يحدث إنه خلاص انتهى ولن يحدث قد يعود
+
+121
+00:09:05,640 --> 00:09:10,900
+مرة أخرى إما من خلال deliberate يعني حاجة متعمدة
+
+122
+00:09:10,900 --> 00:09:17,340
+تمام أو من خلال تغير أنتجيني للفيروس أو اللي هو
+
+123
+00:09:17,340 --> 00:09:23,690
+الـ micro نرجع لموضوعنا جوانب تحدث في كل العالم و
+
+124
+00:09:23,690 --> 00:09:29,600
+بتحدث في حالة تفشيات من سنتين لثلاث سنوات الـ attack
+
+125
+00:09:29,600 --> 00:09:33,600
+rate واحدة من أعلى للـ viral disease بمعنى إن لو
+
+126
+00:09:33,600 --> 00:09:38,760
+كان طفل مصاب وقعد مجموعة، كل المجموعة يجب أن يحدث 
+
+127
+00:09:38,760 --> 00:09:43,420
+لديها هذا الـ disease، مش الكل أو مش البعض ينجو،
+
+128
+00:09:43,420 --> 00:09:47,440
+البعض الآخر لا ينجو، الكل يصاب بالـ measles، ثم بعد ذلك
+
+129
+00:09:47,440 --> 00:09:50,180
+قد يموت أشخاص وينجو أشخاص
+
+130
+00:09:52,750 --> 00:09:55,510
+هذه يمكن هي الجملة الأخيرة اللي حكيناها أنه في الـ
+
+131
+00:09:55,510 --> 00:09:59,470
+و تبان مية جونا devastating worldwide epidemic
+
+132
+00:09:59,470 --> 00:10:07,470
+أكثر في هواي لإنه ما كان عندهم مناعة وذكرنا كلمة mal-
+
+133
+00:10:07,470 --> 00:10:11,830
+nourished اللي هم سوء التغذية برضه كمان لو جينا
+
+134
+00:10:11,830 --> 00:10:17,350
+قارننا نسبة الناس أو حدوث المرض في الأطفال ذوي 
+
+135
+00:10:17,350 --> 00:10:20,710
+التغذية الجيدة بالمقارنة مع ذوي التغذية السيئة
+
+136
+00:10:20,710 --> 00:10:25,370
+سنجد أن حدوث المرض عالية جداً، و أحد الأشياء اللي
+
+137
+00:10:25,370 --> 00:10:29,170
+انتبه إليها الأطباء في ذاك الوقت أنّه vitamin A
+
+138
+00:10:29,170 --> 00:10:34,940
+deficiency بالذات له تأثير كبير، لذلك أدخلوها الـ
+
+139
+00:10:34,940 --> 00:10:40,040
+Vitamin A ضمن الغذاء تبع المرضى تبعهم اللي هم الـ
+
+140
+00:10:40,040 --> 00:10:43,440
+measles حتى يحسّنوا من الـ outcome لـ الـ disease
+
+141
+00:10:43,440 --> 00:10:46,900
+المرضى
+
+142
+00:10:46,900 --> 00:10:50,540
+الجهاز المناعي تبعهم منخفض زي مرضى الـ aids أيضاً لو
+
+143
+00:10:50,540 --> 00:10:53,920
+أصيبوا به الـ measles غالباً بتكون الـ infection
+
+144
+00:10:53,920 --> 00:11:01,130
+fatal يعني قاتلة، هذا مش هينفع على إنه جهاز المناعة ..
+
+145
+00:11:01,130 --> 00:11:05,950
+احنا كنا نقول جهاز المناعة له دور كبير في إيش؟ في
+
+146
+00:11:05,950 --> 00:11:11,390
+إحداث الأعراض، في هذه الحالة عكس ذلك تماماً، جهاز
+
+147
+00:11:11,390 --> 00:11:16,370
+المناعة غير متهم في أن هو المسؤول عن الأعراض، ليش؟
+
+148
+00:11:16,370 --> 00:11:21,360
+مريض الـ aids ما عنده مناعة أساساً، وبالتالي بنقول إن 
+
+149
+00:11:21,360 --> 00:11:26,640
+المرض بيحدث عنده symptoms devastating وممكن تودي
+
+150
+00:11:26,640 --> 00:11:29,400
+إلى الوفاة، ده اللي علامة مجازة المناعة، لم يكن هو
+
+151
+00:11:29,400 --> 00:11:35,420
+المتهم في هذا الأمر، بداية الـ pathogenesis and
+
+152
+00:11:35,420 --> 00:11:39,990
+immunity بعد ما الإصابة بالـ Upper Respiratory
+
+153
+00:11:39,990 --> 00:11:43,270
+Tract، الفيروس بيصل إلى الدم، وبعدين بيروح على
+
+154
+00:11:43,270 --> 00:11:46,730
+Reticular Endothelial System، ومن هناك يتكاثر مرة
+
+155
+00:11:46,730 --> 00:11:52,430
+أخرى، وبعدين بينتقل من الدم إلى الجلد، إذا خلينا
+
+156
+00:11:52,430 --> 00:11:57,310
+نقول إن الـ Final Destination أو الوجهة الأخيرة
+
+157
+00:11:57,310 --> 00:12:04,130
+للفيروس هي الجلد، وهناك بيتكاثر في الـ 
+
+158
+00:12:04,130 --> 00:12:04,630
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+159
+00:12:04,630 --> 00:12:05,150
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+160
+00:12:05,150 --> 00:12:06,230
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+161
+00:12:06,230 --> 00:12:07,270
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+162
+00:12:07,270 --> 00:12:16,410
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+163
+00:12:16,410 --> 00:12:17,090
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+164
+00:12:17,090 --> 00:12:18,490
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+165
+00:12:18,490 --> 00:12:18,530
+الـ الـ الـ الـ الـ الـ الـ الـ 
+
+166
+00:12:26,990 --> 00:12:31,070
+لما احنا افترضناها انها بتكون بدور سلبي، افترضناها
+
+167
+00:12:31,070 --> 00:12:35,850
+بهذا الدور لأنّه بينتج عنه أعراض سلبية، لكن واقع
+
+168
+00:12:35,850 --> 00:12:41,310
+الأمر المسؤول عن إيقاف انتشار الفيروس وتكاثره، هم
+
+169
+00:12:41,310 --> 00:12:45,170
+اثنين في هذه الحالة، الـ antibody بتفاعل مع الـ free
+
+170
+00:12:45,170 --> 00:12:48,710
+virus اللي هو اتكاثر وطلع من الخلايا، و الـ site
+
+171
+00:12:48,710 --> 00:12:52,570
+toxicity cell بتأثر على الـ virally infected cell
+
+172
+00:12:52,570 --> 00:12:56,930
+وبالتالي اثنين بيحيطوا بالفيروس و بيقللوا من إمكانية
+
+173
+00:12:56,930 --> 00:12:59,930
+انتشاره، انتم عارفين ان الاعراض اللي ما تظهر عند
+
+174
+00:12:59,930 --> 00:13:04,270
+مريض الحصبة بيكون already هو غير معدٍ، يعني متى 
+
+175
+00:13:04,270 --> 00:13:08,290
+بيكون معدٍ؟ قبل ما تظهر عليه في فترة الـ incubation
+
+176
+00:13:08,290 --> 00:13:12,370
+period و الـ prodromal، إذا ظهر الطفح على جسمه بيبطل
+
+177
+00:13:12,370 --> 00:13:15,330
+يكون معدٍ، معناه الحاجة ان الـ incubation period
+
+178
+00:13:15,330 --> 00:13:21,840
+فيها طويلة شويّة، هذا الطول بيخلي الجسم يتفاعل
+
+179
+00:13:21,840 --> 00:13:24,980
+مناعياً ينتج أجسام مضادة، لما نقول عشر إلى أربع عشرة
+
+180
+00:13:24,980 --> 00:13:28,580
+يوم، incubation period، إيش معناه الحكي؟ معناه
+
+181
+00:13:28,580 --> 00:13:31,880
+الحكي إنه أنا أعطيت فرصة للجسم إنه أصلاً هي الفترة
+
+182
+00:13:31,880 --> 00:13:37,180
+اللازمة لتكوين أجسام مضادة من عشر إلى أربع عشرة يوم،
+
+183
+00:13:37,180 --> 00:13:41,100
+إذا بالفعل by the time symptoms appear غالباً بيكون
+
+184
+00:13:41,100 --> 00:13:44,480
+الـ virus صار فيه له subsidize أو صار له 
+
+185
+00:13:44,480 --> 00:13:46,320
+neutralization بشكل كبير
+
+186
+00:13:48,760 --> 00:13:52,080
+ممكن يحدث كمان antibody-mediated vasculitis التهاب
+
+187
+00:13:52,080 --> 00:13:56,960
+الأوعية الدموية ناتج عن ارتباط الأنتيجين بالأنتيجين
+
+188
+00:13:56,960 --> 00:13:58,640
+بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين
+
+189
+00:13:58,640 --> 00:13:59,260
+بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين
+
+190
+00:13:59,260 --> 00:14:00,020
+بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين
+
+191
+00:14:00,020 --> 00:14:01,220
+بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين
+
+192
+00:14:01,220 --> 00:14:01,280
+بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين
+
+193
+00:14:01,280 --> 00:14:04,140
+بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين
+
+194
+00:14:04,140 --> 00:14:08,540
+بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين بالأنتيجين
+
+195
+00:14:08,540 --> 00:14:12,580
+بالأنتيجين
+
+196
+00:14:12,580 --> 00:14:18,860
+بالـ lesions اللي بتحدث في المريض بنلاقي فيها
+
+197
+00:14:18,860 --> 00:14:25,620
+الـ multinucleated giant cells، الديزيز بيوفر long
+
+198
+00:14:25,620 --> 00:14:30,180
+life immunity للمصابين اللي recovered من هذا
+
+199
+00:14:30,180 --> 00:14:35,200
+الديزيز، على الرغم من أن الـ IgG بيلعب دور كبير جداً في
+
+200
+00:14:35,200 --> 00:14:39,620
+المناعة ضد الـ measles إلا أن الدور الأكبر يا
+
+201
+00:14:39,620 --> 00:14:42,980
+جماعة لمن؟ لـ cell-mediated immunity عشان هي كده
+
+202
+00:14:42,980 --> 00:14:45,960
+مرضى الـ HIV قلنا لكم لو أصيبوا بصير عندهم
+
+203
+00:14:45,960 --> 00:14:51,780
+devastating measles و ممكن يموت، في حاجة مميزة جداً
+
+204
+00:14:51,780 --> 00:14:57,970
+في مرضى الـ measles في اللسان تبعهم، و تعتبر علينا
+
+205
+00:14:57,970 --> 00:15:02,810
+diagnostic بمعنى أن الطبيب إذا شافها هو ليس بحاجة
+
+206
+00:15:02,810 --> 00:15:08,270
+إلى أن يعمل confirmatory laboratory test، اسم الـ
+
+207
+00:15:08,270 --> 00:15:13,210
+finding Koplik spot، لو طلعنا على الصورة اللي
+
+208
+00:15:13,210 --> 00:15:17,650
+أمامنا هنا بنلاقي في slightly pinkish spots
+
+209
+00:15:21,410 --> 00:15:25,650
+مش اللون أبيض أو مش .. يعني اللون خلينا نقول زائد
+
+210
+00:15:25,650 --> 00:15:31,890
+عن زهري هنا، وفي عندي هنا white spot شايفينها white
+
+211
+00:15:31,890 --> 00:15:34,290
+spot أكيد في الـ .. في الـ presentation اللي هتكون 
+
+212
+00:15:34,290 --> 00:15:38,870
+موجودة معاكم هتكون الصورة أوضح، هذا الـ finding اسمه
+
+213
+00:15:38,870 --> 00:15:42,330
+Koplik spot، هذا الـ Koplik spot وجودها يعني
+
+214
+00:15:42,330 --> 00:15:47,720
+measles، ففي ارتباط بين اثنين اثنين، بعد كام يوم
+
+215
+00:15:47,720 --> 00:15:50,620
+بيبدأ الـ maculopapular rash اللي قلنا عنه هو
+
+216
+00:15:50,620 --> 00:15:55,920
+الأحمرار موجود على الوجه و بينزل تدريجياً على الجسم
+
+217
+00:15:55,920 --> 00:15:59,360
+و الـ lower extremities و بيصيب اللي ورا حتى اليد
+
+218
+00:15:59,360 --> 00:16:04,390
+حتى و الرجل The rash develops a brownish hue
+
+219
+00:16:04,390 --> 00:16:11,670
+several days later بعد عدة أيام بيصير في لون
+
+220
+00:16:11,670 --> 00:16:18,650
+بني خفيف و بيختفي و بيذوي تدريجياً حتى يعود الجلد
+
+221
+00:16:18,650 --> 00:16:23,890
+مرة أخرى بنفس اللوحة الأخيرة، في هذه اللوحة بتقول
+
+222
+00:16:23,890 --> 00:16:28,190
+أن الـ complication لـ الـ measles can be quite severe
+
+223
+00:16:30,020 --> 00:16:33,100
+مضاعفة .. إيش من مضاعفتها؟ من مضاعفتها
+
+224
+00:16:33,100 --> 00:16:33,920
+Encephalitis
+
+225
+00:16:36,800 --> 00:16:43,700
+بتحدث بنسبة أو بـ rate تمام واحد لكل ألف حالة من الـ
+
+226
+00:16:43,700 --> 00:16:47,600
+measles يعني من كل ألف مصاب بيحدث لنا حالة واحدة
+
+227
+00:16:47,600 --> 00:16:52,680
+encephalitis، الآن تعالى نطلع سيبولنا الآن من الرقم
+
+228
+00:16:52,680 --> 00:16:57,280
+الواحد الواحد، ما هو من ألف بيصير لنا رقم كبير الآن
+
+229
+00:16:57,280 --> 00:17:01,700
+من هذا الرقم اللي هم عندهم encephalitis عشرة في
+
+230
+00:17:01,700 --> 00:17:07,970
+المئة بيموتوا، 10% منهم بيموتوا، و 40% منهم بيصير
+
+231
+00:17:07,970 --> 00:17:13,470
+عندهم mental retardation، خلينا نسميها permanent
+
+232
+00:17:13,470 --> 00:17:18,910
+sequela، يعني آثار دائمة، إعاقات دائمة مثل
+
+233
+00:17:18,910 --> 00:17:24,110
+deafness، فقدان السمع أو mental retardation، إذا
+
+234
+00:17:24,110 --> 00:17:28,370
+الـ Encephalitis اللي بتيجي معاها الـ measles خطيرة
+
+235
+00:17:28,370 --> 00:17:32,770
+ونسبة القتل فيها عالية ونسبة اللي هو قلنا كمان مرة
+
+236
+00:17:32,770 --> 00:17:39,020
+الـ mental و الـ deafness فيها أيضاً عالية، إضافة لما
+
+237
+00:17:39,020 --> 00:17:44,520
+ذكرنا من complication الـ measles، ما هي جون عنها
+
+238
+00:17:44,520 --> 00:17:47,820
+primarily وين بتصيب؟ في الـ lungs صح أو لا؟ ممكن
+
+239
+00:17:47,820 --> 00:17:50,680
+تعمل هي نفسها pneumonia زي الـ influenza أو زي ما
+
+240
+00:17:50,680 --> 00:17:52,980
+قلت لك بالضبط الـ influenza، إما هي نفسها بتعمل
+
+241
+00:17:52,980 --> 00:17:58,200
+pneumonia أو secondary pneumonia، bacterial pneumonia
+
+242
+00:17:58,200 --> 00:18:01,580
+وهذا اللي بيزيد كمان مرة بالنسبة للوفيات في هذا
+
+243
+00:18:01,580 --> 00:18:05,660
+المرض الخطير أيضاً
+
+244
+00:18:06,210 --> 00:18:09,870
+يولد لدينا إمكانية إصابة أطفال بـ otitis media
+
+245
+00:18:09,870 --> 00:18:13,270
+الالتهاب الأذن الوسطى ناتج عن اللي هو هذا الـ virus
+
+246
+00:18:13,270 --> 00:18:17,870
+وفي مرض خطير جداً جداً و غريب في نفس الوقت لإنه لا
+
+247
+00:18:17,870 --> 00:18:22,070
+يصيب الطفل اليوم المصاب وإنما يصيبه بعد عدة سنوات
+
+248
+00:18:22,070 --> 00:18:28,140
+من إصابته به اللي هو الـ disease اسمه sub acute
+
+249
+00:18:28,140 --> 00:18:34,320
+sclerosing panencephalitis أو SSPE كمان مرة sub
+
+250
+00:18:34,320 --> 00:18:40,340
+acute sclerosing panencephalitis و rare لكن fatal
+
+251
+00:18:40,340 --> 00:18:44,300
+disease  قاتل of the central nervous system that
+
+252
+00:18:44,300 --> 00:18:47,560
+occurs several years after measles يعني بيحدث بعد
+
+253
+00:18:47,560 --> 00:18:51,540
+عدة سنوات من مرض اللي هو الحصبة
+
+254
+00:18:52,730 --> 00:18:56,150
+measles in pregnant women برضه بشكل خطورة كبيرة
+
+255
+00:18:56,150 --> 00:18:59,570
+جدا lead to an increased risk of still birth still
+
+256
+00:18:59,570 --> 00:19:03,770
+birth يعني يولد ميتا يعني بيكمل ال term لكن بيولد 
+
+257
+00:19:03,770 --> 00:19:09,140
+ميتا rather than congenital abnormalities يعني هذه
+
+258
+00:19:09,140 --> 00:19:12,440
+الاحتمالية أن يولد ميتا أعلى من احتمالية أنه يصير
+
+259
+00:19:12,440 --> 00:19:15,140
+عنده congenital abnormalities ال congenital
+
+260
+00:19:15,140 --> 00:19:19,300
+abnormalities ارتبطت بمين؟ ارتبطت بالربلة ارتبطت
+
+261
+00:19:19,300 --> 00:19:23,120
+بالربلة لذلك هم بيقولوا أن ال measles is more
+
+262
+00:19:23,120 --> 00:19:28,080
+severe ليه؟ ال measles قتلت المولود أو الجنين
+
+263
+00:19:28,080 --> 00:19:32,100
+بينما الربلة فقط عملت congenital abnormality
+
+264
+00:19:34,080 --> 00:19:38,100
+الـ laboratory diagnosis للديزيز غالبا ال most
+
+265
+00:19:38,100 --> 00:19:42,640
+common diagnosis جونا is based on clinical ground، إيش ال
+
+266
+00:19:42,640 --> 00:19:47,500
+clinical ground؟ ال complex spot؟ وإيش كمان؟
+
+267
+00:19:47,500 --> 00:19:51,360
+الرعشة اللي جونا عنها بتبدأ في الوجه وبتنتشر إلى
+
+268
+00:19:51,360 --> 00:19:54,820
+باقي أجزاء الجسم وبتكون موجودة على وحتي اليد وال
+
+269
+00:19:54,820 --> 00:20:03,940
+القدم لكن أيضا يمكن قياس الـ antibody titer
+
+270
+00:20:03,940 --> 00:20:09,040
+ونعرف إن ال four fold increase من ال acute إلى ال
+
+271
+00:20:09,040 --> 00:20:17,300
+convalescent period لسوء حظنا إن مافي لنا أي
+
+272
+00:20:17,300 --> 00:20:22,020
+antiviral therapy لهذا ال disease لكن لحُسن الحظ إن 
+
+273
+00:20:22,020 --> 00:20:25,940
+في عندنا إمكانية إنه نعمل prevention لهذا ال
+
+274
+00:20:25,940 --> 00:20:30,660
+disease وهو من خلال ال vaccination اتطلعولي على 
+
+275
+00:20:30,660 --> 00:20:37,340
+الفترة الزمنية اللي بنعطيها الفاكسين أول مرة، 
+
+276
+00:20:37,340 --> 00:20:42,180
+بنعطيها على عمر 15 شهر من العمر ويمكن
+
+277
+00:20:42,180 --> 00:20:45,580
+احنا ناقشنا هذا الموضوع صادقا وقلنا لكم يا بنات
+
+278
+00:20:45,580 --> 00:20:50,840
+طالما أنتو إنتم الآن مطعمين يبقى المولود الناتج
+
+279
+00:20:50,840 --> 00:20:54,860
+عنكم أيضا هيكون فيه انتقل الها antibodies منكم
+
+280
+00:20:54,860 --> 00:20:59,210
+إليهم لو أعطيناهم فكسين في ال day one و day two و
+
+281
+00:20:59,210 --> 00:21:02,430
+month one و month two، غالبا بالضبط ال antibody
+
+282
+00:21:02,430 --> 00:21:05,810
+اللي هي maternal بسميها antibody will neutralize
+
+283
+00:21:05,810 --> 00:21:09,650
+اللي هو الفيروس وبالتالي ال immunization نفسها هتكون
+
+284
+00:21:09,650 --> 00:21:11,050
+كفائتها أقل
+
+285
+00:21:13,650 --> 00:21:17,890
+الآن ال vaccine لا يُعطى لوحده وإنما يُعطى ضمن
+
+286
+00:21:17,890 --> 00:21:24,110
+صفقة اسمها MMR اللي هم ال measles, mumps و الربلة
+
+287
+00:21:24,110 --> 00:21:28,370
+طبعا التلاتة بيشتركوا ببعض الصفات وبالتالي يعني
+
+288
+00:21:28,370 --> 00:21:31,670
+لهم one single zero types وعطيناهم مع بعض وكانت
+
+289
+00:21:31,670 --> 00:21:37,930
+كفائتهم مع بعض جيدة فاكرين مرة في ال adenovirus
+
+290
+00:21:37,930 --> 00:21:43,460
+عطينا لل .. لل military recruits عطيناهم vaccine
+
+291
+00:21:43,460 --> 00:21:47,640
+لكن عطيناهم vaccine وحادي وحادي وحادي بمعني آخر
+
+292
+00:21:47,640 --> 00:21:52,620
+هما تلاتة على تلت فترات متباعدة وإيش كان السبب؟ أن
+
+293
+00:21:52,620 --> 00:21:55,460
+واحد بيعمل interference مع التاني، تبقي مش
+
+294
+00:21:55,460 --> 00:21:57,960
+هتعطيناهم مع بعض ومبسوطين أنهم قاطينهم مع بعض ..
+
+295
+00:21:57,960 --> 00:22:03,420
+مع بعض واضح أنهم بيستهدفوا .. واضح أنهم بيستهدفوا
+
+296
+00:22:03,420 --> 00:22:08,320
+أنسجة أو خلايا مختلفة وبالتالي ماحدش بيترعرض مع مين؟
+
+297
+00:22:08,320 --> 00:22:09,100
+مع التاني
+
+298
+00:22:13,830 --> 00:22:16,770
+طبعا احنا نوضح دالش بنعطي vaccination على خمساشر
+
+299
+00:22:16,770 --> 00:22:22,550
+شهر لكن بيكونوا تعرفوا أن ال vaccine لا يعطي مناعة
+
+300
+00:22:22,550 --> 00:22:28,750
+مثل ال natural infection وبالتالي immunity و ال
+
+301
+00:22:28,750 --> 00:22:35,750
+wane و كلمة wane يعني سوف تذوي يعني تنحدر تدريجيا
+
+302
+00:22:35,750 --> 00:22:39,470
+لذلك booster dose وكلمة booster عرفناها برضه
+
+303
+00:22:39,470 --> 00:22:42,470
+واتكلمنا فيها قبل هيك booster هي الجرعة المنشطة أو
+
+304
+00:22:42,470 --> 00:22:47,810
+الجرعة المعززة دائمة لجهاز المناعة ال vaccine
+
+305
+00:22:47,810 --> 00:22:50,310
+should not be given to immunocompromised or
+
+306
+00:22:50,310 --> 00:22:54,490
+pregnant women معلومة
+
+307
+00:22:54,490 --> 00:22:58,030
+مهمة جدا كلمة immunocompromised ده جماعة احنا برضه
+
+308
+00:22:58,030 --> 00:23:03,320
+مرارا وتكرارا قلنا لكم لا يمكن قياسها لكن الطفل
+
+309
+00:23:03,320 --> 00:23:09,260
+المريض هو immunocompromised يعني ما نروحش نطعم طفل
+
+310
+00:23:09,260 --> 00:23:13,760
+وعنده حمى لأن الجهاز المناعة تبعه الآن هو ضعيف و
+
+311
+00:23:13,760 --> 00:23:17,860
+مشغول ب disease فإذا عطنا هذا live attenuated
+
+312
+00:23:17,860 --> 00:23:24,440
+vaccine قد يحدث لديه المرض بشكل يعني كأنه مريض
+
+313
+00:23:24,440 --> 00:23:27,880
+measles وهذا ممكن يؤثر عليه ويؤذيه أيضا
+
+314
+00:23:27,880 --> 00:23:31,900
+فبالتالي ما لازم يكون المفهوم لدينا أن كلمة طفل
+
+315
+00:23:31,900 --> 00:23:34,640
+مريض لا يتعرض ل vaccination
+
+316
+00:23:37,600 --> 00:23:42,260
+الـ Vaccine أدى إلى خفض عدد حالات الـ Measles في
+
+317
+00:23:42,260 --> 00:23:48,000
+الولايات المتحدة بشكل دراماتيكي في سنة 1997 تم
+
+318
+00:23:48,000 --> 00:23:56,060
+تسجيل في كل الولايات المتحدة فقط 138 حالة Measles
+
+319
+00:23:56,060 --> 00:24:00,460
+هذا رقم يعني ليس كان في الدول 138 حالة بالنسبة
+
+320
+00:24:00,460 --> 00:24:04,230
+للملايين اللي كانت موجودة فيه السنة however
+
+321
+00:24:04,230 --> 00:24:06,750
+ومع ذلك outbreaks can still occur among
+
+322
+00:24:06,750 --> 00:24:16,310
+unimmunized individuals يعني في المدن
+
+323
+00:24:16,310 --> 00:24:19,730
+اللي داخل المدن زي ما هنالك ناس محوطين حالهم أو
+
+324
+00:24:19,730 --> 00:24:26,030
+منعزلين عن المدينة بصفات معينة بعداد معينة
+
+325
+00:24:26,030 --> 00:24:30,440
+وبيمتنعوا عن الحصول على اللي هو ال vaccination الـ
+
+326
+00:24:30,440 --> 00:24:32,520
+killed vaccine should not be used وقلنا لكوا
+
+327
+00:24:32,520 --> 00:24:39,380
+ما بتعطيش مناعة جيدة للمرض، هناك أيضا تحضيرات اسمها
+
+328
+00:24:39,380 --> 00:24:44,380
+immunoglobulin للميسلز can be used to modify the
+
+329
+00:24:44,380 --> 00:24:47,920
+disease، إيش يعني modify the disease؟ يعني نعدل
+
+330
+00:24:47,920 --> 00:24:51,140
+المسار تبع المرض، المسار تبع المرض خطير، احنا بدنا
+
+331
+00:24:51,140 --> 00:24:56,240
+نعدله إلى إنه يكون أقل خطورة من خلال استخدامنا لل
+
+332
+00:24:56,240 --> 00:25:01,260
+immunoglobulin متى .. متى بنلجأ إلها؟ بنعطيها لـ
+
+333
+00:25:01,260 --> 00:25:05,120
+unimmunized individuals يعني أشخاص ما اتوا .. ما اتوا
+
+334
+00:25:05,120 --> 00:25:09,360
+طعموا لأسباب معينة، فترة الولادة، سافروا من مكان
+
+335
+00:25:09,360 --> 00:25:12,920
+إلى مكان، المكان .. لا .. لا طعموا في المكان اللي
+
+336
+00:25:12,920 --> 00:25:16,040
+هم كانوا فيه ولا للمكان اللي انتقلوا منه، ضمن منهم
+
+337
+00:25:16,040 --> 00:25:19,100
+أنهم حصلوا على هذا التطعيم على سبيل المثال، هذا
+
+338
+00:25:19,100 --> 00:25:24,840
+أحد الأمثلة اللي بنشوفها أو اللي بيغطيهاش بعض
+
+339
+00:25:24,840 --> 00:25:30,320
+الأحيان ال vaccine This is especially necessary if
+
+340
+00:25:30,320 --> 00:25:34,360
+the unimmunized individuals are immunocompromised
+
+341
+00:25:34,360 --> 00:25:38,260
+خاصة إذا كانوا بالفعل الأشخاص دول اللي مش
+
+342
+00:25:38,260 --> 00:25:41,480
+immunized وفي نفس الوقت ما لهم immunocompromised،
+
+343
+00:25:41,480 --> 00:25:44,640
+احنا ما نعطيهمش vaccine، إذا ما اعطيهم immunoglobulin
+
+344
+00:25:44,640 --> 00:25:52,300
+الفيروس التاني اللي عمل يعني ضجة عالمية قبل عامين
+
+345
+00:25:52,300 --> 00:25:55,660
+في فلسطين هو ال mumps virus
+
+346
+00:25:58,760 --> 00:26:04,620
+و مدام يعني كمقدمة خليني أتكلم عن ما حدث ونربطه
+
+347
+00:26:04,620 --> 00:26:09,760
+ببعض المعلومات اللي كانت لدينا موجودة السابق كان
+
+348
+00:26:09,760 --> 00:26:13,140
+فينا طالبة مجلستها رحنا أشرف عليها الأستاذ الدكتور
+
+349
+00:26:13,140 --> 00:26:17,460
+محمد عيد الشبير وأنا ساعدته في هذه الرسالة للكشف
+
+350
+00:26:17,460 --> 00:26:24,080
+عن مدى نجاعة التطعيم لمجموعة من الأمراض الفيروسية
+
+351
+00:26:24,080 --> 00:26:29,180
+منها ال MMR وبكتيريا اللي هي ال
+
+352
+00:26:29,180 --> 00:26:31,740
+Bordetella pertussis هدولة كانت الأربع اللي هو ال
+
+353
+00:26:31,740 --> 00:26:34,700
+target اللي لنا فكانت ناخد عينات من أطفال من أعمار
+
+354
+00:26:34,700 --> 00:26:40,900
+مختلفة ونقيس مستوى ال antibody لل .. للفيروسات
+
+355
+00:26:40,900 --> 00:26:46,270
+التلاتة و ال .. و ال .. و البكتيريا هو طبعا في
+
+356
+00:26:46,270 --> 00:26:50,190
+المحصرة النهائية أقوله مثلا أنا لقد كل الأرقام
+
+357
+00:26:50,190 --> 00:26:55,430
+الصحيحة 200 طفل 300 طفل النسب اللي طلعت معانا بتقول
+
+358
+00:26:55,430 --> 00:27:01,530
+أن الكفاءة تبعت ال vaccine بعضهم وصلت ل 90% وفي
+
+359
+00:27:01,530 --> 00:27:06,530
+منهم فقط ل 70% ال mumps كان واحد من ال ايه من
+
+360
+00:27:06,530 --> 00:27:11,310
+المنخفضين فكنا لسه من الدعوة لإنه ليش الكفاءة تبع
+
+361
+00:27:11,310 --> 00:27:16,410
+هذا الفيروس أو عفوا الفاكسين ضعيفة في قطاع غزة طب
+
+362
+00:27:16,410 --> 00:27:19,470
+هذا ممكن يشكل خطر وهذا بالعامل اللي بعديه ليه
+
+363
+00:27:19,470 --> 00:27:24,230
+مباشرة إذا بيحدث عندنا اللي هو الأوجهة النقطة اللي
+
+364
+00:27:24,230 --> 00:27:28,470
+بدكرها هذي بدكرها عشان أقولكوا أنه أي vaccination
+
+365
+00:27:28,470 --> 00:27:32,370
+program لازم يصير له evaluation، إيش يعني
+
+366
+00:27:32,370 --> 00:27:37,350
+evaluation؟ تقييم، بنفحص طاعة من الناس و بنشوف إن
+
+367
+00:27:37,350 --> 00:27:42,390
+خلاص هذا ال vaccine فعال تمام، في أمريكا حاجة
+
+368
+00:27:42,390 --> 00:27:48,350
+اسمها cold transport chain، إيش ال cold transport
+
+369
+00:27:48,350 --> 00:27:54,750
+chain؟ اللي هي نقل ال vaccine من مصنعه إلى مخزنه،
+
+370
+00:27:54,750 --> 00:27:58,710
+طبعا مصنعه مش هنا، مصنعه في دول بعيدة جدا، واحنا
+
+371
+00:27:58,710 --> 00:28:01,070
+للأسف يعني اللي بيجينا بينتقل إلينا وبيروح على
+
+372
+00:28:01,070 --> 00:28:04,150
+حواجز، بنزل في ميناء أسدود، وبيقول له كام من يوم، و
+
+373
+00:28:04,150 --> 00:28:07,270
+بيجي على حاجز إيرز، وبيقول له كام من يوم، وبعدين
+
+374
+00:28:07,270 --> 00:28:10,470
+اللي بيقولوا عنه هنا، فبالتالي قد يتأثر، خاصة
+
+375
+00:28:10,470 --> 00:28:13,910
+المشكلة مع مين احنا، عن live attenuated vaccine
+
+376
+00:28:14,500 --> 00:28:16,600
+هذا جانب من الجوانب اللي احنا لازم نعملها
+
+377
+00:28:16,600 --> 00:28:21,300
+evaluation لذلك خذوا بالكم، مش المفروض نستلم الشحنة
+
+378
+00:28:21,300 --> 00:28:26,620
+اللي ده كان معنا سجل، يسجل تاريخ الرحلة من أول ما
+
+379
+00:28:26,620 --> 00:28:32,590
+طلعت إلى آخر ما وصلتني، تاريخ سجل التلاجات بيكون فيه
+
+380
+00:28:32,590 --> 00:28:37,390
+chart أو اليوم برامج الحاسوب بتعطينا سجل كل دقيقة
+
+381
+00:28:37,390 --> 00:28:41,130
+بتسجل درجة الحرارة في هذا المكان، إذا فشلوا أنه في
+
+382
+00:28:41,130 --> 00:28:44,750
+نصف ساعة يعطوني، واجت نصف ساعة، فهذه الشحنة غير مقبولة
+
+383
+00:28:44,750 --> 00:28:50,960
+لدينا على سبيل المثال، الجانب الثاني، أن أنا قاعد
+
+384
+00:28:50,960 --> 00:28:55,080
+باعطي جرعة... جرعة ل... حتى لو ضمنت أن ال... أن
+
+385
+00:28:55,080 --> 00:28:58,400
+ال... أن الـ cold transport chain كانت فعالة ممتازة
+
+386
+00:28:58,400 --> 00:29:02,180
+و التخزين كان جيد، هل هناك ضمانة أن الـ vaccine 
+
+387
+00:29:02,180 --> 00:29:06,300
+نفسه يكون effective؟ ما فيش ضمانة، هو بالتالي الأصل
+
+388
+00:29:06,300 --> 00:29:10,640
+أن نفس الجهة المسؤولة عن الـ vaccination تقوم
+
+389
+00:29:10,640 --> 00:29:16,260
+بدراسات لمعرفة مدى نجاعة هذه الـ vaccine، وإلا في
+
+390
+00:29:16,260 --> 00:29:18,820
+يوم من الأيام حصلنا و اباق و نقول طب يا عم احنا كنا
+
+391
+00:29:18,820 --> 00:29:22,360
+عاملين و خسرانين يعني ملايين الدولارات على الـ
+
+392
+00:29:22,360 --> 00:29:25,520
+vaccination، الـ vaccination expensive و خاصة بتغطي
+
+393
+00:29:25,520 --> 00:29:29,460
+كل السكانة بتاعتي، هي تكلفة عالية، و بتاعتي لازم تكون
+
+394
+00:29:29,460 --> 00:29:33,580
+بالفعل دهت كفاءة، و ما نتفاجأ فجأة أن سينا و اباق زي
+
+395
+00:29:33,580 --> 00:29:36,760
+مثلا، و اباق اللي هو الـ mumps اللي احنا كنا اعتقدنا
+
+396
+00:29:36,760 --> 00:29:40,940
+في السابق أن خلاص يعني خلصنا منه، في السابق كذلك
+
+397
+00:29:40,940 --> 00:29:44,440
+الأمر بالنسبة للـ border tell apertosis لم نجد يعني
+
+398
+00:29:44,440 --> 00:29:49,580
+نسب عالية من الكفاءة للـ vaccine، و بتاعتي بنقول أن
+
+399
+00:29:49,580 --> 00:29:56,080
+لابد من يعني التركيز على الدراسات أو البرامج اللي
+
+400
+00:29:56,080 --> 00:30:01,120
+بتضمن أن الـ الـ vaccinations يصير لها evaluation
+
+401
+00:30:01,120 --> 00:30:05,660
+بشكل مستمر، حتى لو نفاجأ بهذا الشكل، طيب هذا اللي
+
+402
+00:30:05,660 --> 00:30:09,120
+خلانا نتكلم عنه، مين الـ mumps و الوباء اللي صار في
+
+403
+00:30:09,120 --> 00:30:14,240
+الـ mumps العام، الـ mumps disease، this virus causes
+
+404
+00:30:14,240 --> 00:30:18,080
+mumps، a disease characterized by a parotid gland
+
+405
+00:30:18,080 --> 00:30:20,380
+swelling، عارفين الـ parotid gland؟
+
+406
+00:30:23,250 --> 00:30:28,170
+It occurs primarily in childhood، برضه مرض بيصيب
+
+407
+00:30:28,170 --> 00:30:31,710
+الطفولة، أو فيه حدث في الطفولة، عفوا، important
+
+408
+00:30:31,710 --> 00:30:36,570
+properties of the genome are RNA and nucleocapsid
+
+409
+00:30:36,570 --> 00:30:42,250
+are those of typical paramyxovirus، يعني negative
+
+410
+00:30:42,250 --> 00:30:48,100
+sense single-stranded mRNA، بيحتوي على RNA-dependent
+
+411
+00:30:48,100 --> 00:30:51,040
+RNA polymerase، هيليكال نوكليوكابوسيد، وإيش كمان
+
+412
+00:30:51,040 --> 00:30:54,600
+اللي هو envelope، يعني هو الـ typical paramyxo
+
+413
+00:30:54,600 --> 00:30:59,360
+فيروس، هن نيجي لك نتكلم عن الـ envelope spikes في
+
+414
+00:30:59,360 --> 00:31:03,020
+الـ mumps، في أنهين؟ هيمأجلوتينين و neuroaminidase
+
+415
+00:31:03,720 --> 00:31:07,080
+activities، and the other with cell fusion and
+
+416
+00:31:07,080 --> 00:31:10,860
+hemolytic activity، تخيلوا واحد بيحتوي على
+
+417
+00:31:10,860 --> 00:31:14,580
+neuroaminidase، و في نفس الوقت إيش بيحتوي على ال... ال
+
+418
+00:31:14,580 --> 00:31:17,480
+... الـ hemagglutinin، طبعا في ال... في الـ orthopoxy
+
+419
+00:31:17,480 --> 00:31:22,640
+virus، كان واحد neuroaminidase، واحد hemagglutinin، هنا
+
+420
+00:31:22,640 --> 00:31:27,120
+اتنين على one single spike، و التاني له cell fusion
+
+421
+00:31:27,120 --> 00:31:31,480
+and hemolytic activity، إذا أنا مغطي مين؟ مغطيهم
+
+422
+00:31:31,480 --> 00:31:36,410
+كلهم، هي مبقى هيمأجلوتينين، نيرو أميديز، زاد اللي هو cell
+
+423
+00:31:36,410 --> 00:31:43,290
+fusion، الفيروين لديه اتجارات اتجارات اتجارات
+
+424
+00:31:43,290 --> 00:31:43,870
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+425
+00:31:43,870 --> 00:31:47,710
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+426
+00:31:47,710 --> 00:31:53,230
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+427
+00:31:53,230 --> 00:31:53,990
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+428
+00:31:53,990 --> 00:31:54,690
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+429
+00:31:54,690 --> 00:32:06,530
+اتجارات اتجارات اتجارات اتجارات 
+
+430
+00:32:07,930 --> 00:32:11,770
+The internal nucleocapsid protein is the S، و سماه
+
+431
+00:32:11,770 --> 00:32:14,910
+soluble antigen، detecting in the complement
+
+432
+00:32:14,910 --> 00:32:17,750
+fixation test for the diagnosis، إذا هذه الجملة
+
+433
+00:32:17,750 --> 00:32:20,610
+بتقولنا أنه في معلومة ثانية بتقولنا أن الـ
+
+434
+00:32:20,610 --> 00:32:23,650
+diagnosis بتتم من خلال complement fixation test
+
+435
+00:32:23,650 --> 00:32:27,590
+.بنكشف فيه عن مين؟ عن soluble antigen، و اين موجود في
+
+436
+00:32:27,590 --> 00:32:32,450
+الـ nucleocapsin، Human are the natural أو the only
+
+437
+00:32:32,450 --> 00:32:39,510
+natural host for this virus، إذا بيقدر يستنتج من
+
+438
+00:32:39,510 --> 00:32:44,390
+هذه اللوحة أنه في كثير شبه بين الـ mumps و بين اللي
+
+439
+00:32:44,390 --> 00:32:48,450
+هو الـ para... عفوا، الـ measles virus، إيش أوجد
+
+440
+00:32:48,450 --> 00:32:52,850
+الشبه كلاهما؟ Paramyxovirus، كلاهما يمتلك نفس
+
+441
+00:32:52,850 --> 00:32:58,690
+الخصائص، لكن هناك بعض الاختلافات، التشابهات ذكرناها، و
+
+442
+00:32:58,690 --> 00:33:02,470
+ذكرنا أن هو single serotype، و الـ human are the
+
+443
+00:33:02,470 --> 00:33:05,970
+only natural host، لكن الاختلاف في موضوع اللي هو الـ
+
+444
+00:33:05,970 --> 00:33:10,250
+spikes، أن الـ spikes neuroaminidase و هي مقالوتنين on
+
+445
+00:33:10,250 --> 00:33:14,230
+one spike، و على الطرف الثاني فيه أن اللي هو الـ
+
+446
+00:33:14,230 --> 00:33:18,450
+fusion protein أيضا
+
+447
+00:33:18,450 --> 00:33:21,190
+من أوجه الشبه أن بينتقلوا الاثنين عن اللي هو الـ
+
+448
+00:33:21,190 --> 00:33:24,960
+respiratory droplets أو respiratory tract، mumps
+
+449
+00:33:24,960 --> 00:33:29,400
+أكثر أيضا worldwide، هذا برضه أي وجه شبه، with a
+
+450
+00:33:29,400 --> 00:33:33,800
+peak incidence in the winter، فاكرين كلمة winter
+
+451
+00:33:33,800 --> 00:33:39,860
+نقشناها قبل كده ولا ما نقشناها، الشتاء؟ لماذا يكون بعض
+
+452
+00:33:39,860 --> 00:33:43,840
+الأمراض مثل الـ influenza في الشتاء، زي واحدة كمان
+
+453
+00:33:43,840 --> 00:33:47,620
+نفس الشيء في الشتاء أكثر منه في الصيف؟ طبعا
+
+454
+00:33:47,620 --> 00:33:51,920
+الإجابة المنطقية اللي لديكم أن هو درجة من الحرارة
+
+455
+00:33:51,920 --> 00:33:59,180
+كيف لدرجة الحرارة أن تؤثر على انتقال الفيروس هذا
+
+456
+00:33:59,180 --> 00:34:03,280
+السؤال، مش السؤال أن درجة الحرارة و خلاص، اللي احنا
+
+457
+00:34:03,280 --> 00:34:07,360
+هنا في ال... في ال... في المساجد... في المساجد على
+
+458
+00:34:07,360 --> 00:34:11,580
+سبيل المثال، في فصل الشتاء بنلاقيش ولا شباك مفتوح
+
+459
+00:34:13,670 --> 00:34:18,010
+و مغلق، لو كان واحد مصاب، بكل سهولة بينشر، في الصيف
+
+460
+00:34:18,010 --> 00:34:20,890
+فيه تهوية، فبالتالي فيه تيار دائما بيلف لف،
+
+461
+00:34:20,890 --> 00:34:24,810
+فبالتالي فيه، خذنا نقول distribution أو dilution
+
+462
+00:34:24,810 --> 00:34:28,290
+للفيروس، فكمية الفيروس اللي بياخدها بتكون إيه؟ أقل
+
+463
+00:34:28,290 --> 00:34:31,690
+طبعا، بقول هذا سلوك سيء، أن احنا نسكر الشبابيك بشكل
+
+464
+00:34:31,690 --> 00:34:36,630
+... بشكل تام، و خاصة في أماكن مغلقة مثل القاعات
+
+465
+00:34:36,630 --> 00:34:41,030
+الصفية هذه، أو ال... ال... المساجد، أو أي قاعات
+
+466
+00:34:41,030 --> 00:34:46,710
+اجتماعات أخرى، هذا أحد العوامل، الناس يميلوا إلى
+
+467
+00:34:46,710 --> 00:34:51,490
+الاقتراب من بعضهم في فصل الشتاء، ما يهتموش لأنهم
+
+468
+00:34:51,490 --> 00:34:54,170
+يكونوا بعيد عن بعض، ففيه بيكون close contact، دي
+
+469
+00:34:54,170 --> 00:34:58,890
+كمان عامل ثالث اللي هو الـ survival تبع الفيروس في
+
+470
+00:34:58,890 --> 00:35:03,330
+الـ environment، هذا enveloped صح؟ و أنت عارفين أن
+
+471
+00:35:03,330 --> 00:35:06,870
+الـ envelope virus الـ survival تبعه هيكون ضعيف، الـ
+
+472
+00:35:06,870 --> 00:35:10,410
+low temperature، الـ survival rate تبعتها بيكون أعلى
+
+473
+00:35:10,620 --> 00:35:14,280
+يبقى بقاءها في الـ environment في فصل الشتاء بيكون
+
+474
+00:35:14,280 --> 00:35:18,060
+أفضل من بقاءها في من فصل اللي هو الصيف، فبعطيها
+
+475
+00:35:18,060 --> 00:35:22,260
+فرصة أكبر في الانتقال من إنسان إلى إنسان آخر
+
+476
+00:35:22,260 --> 00:35:28,580
+تقريبا ثلاثين بالمية من الأطفال اللي بيصابوا بيكون
+
+477
+00:35:28,580 --> 00:35:31,780
+عندهم subclinical، و كلمة subclinical يعني لا يظهر
+
+478
+00:35:31,780 --> 00:35:37,390
+عليهم أي أعراض، هكذا بنعرف أنهم أصيبوا من خلال فقط
+
+479
+00:35:37,390 --> 00:35:40,610
+فحص antibody، يعني surveillance... surveillance
+
+480
+00:35:40,610 --> 00:35:48,890
+survey، there were only 683 reported cases of mumps
+
+481
+00:35:48,890 --> 00:35:53,010
+in the United States in 1997، برضه الرقم في
+
+482
+00:35:53,010 --> 00:36:00,150
+الولايات المتحدة 683 في الـ 1997، هذا رقم دقيق جدا
+
+483
+00:36:00,150 --> 00:36:06,100
+على بال سكان خنيونيس، طلع أكثر منهم في تلك الفترة
+
+484
+00:36:06,100 --> 00:36:09,800
+أهل خنيونيس أعطوه الذهب له... هو... هو... هو بدأ
+
+485
+00:36:09,800 --> 00:36:13,180
+في خنيونيس، بس انتقل على كل اللي هو القطاع تقريبا، و
+
+486
+00:36:13,180 --> 00:36:19,120
+أكثر يعني ناس أصيبهم فيه من أطفال المدارس، القصد من
+
+487
+00:36:19,120 --> 00:36:23,860
+الكلام أن الـ vaccination الفعال كان له تأثير كبير
+
+488
+00:36:23,860 --> 00:36:27,840
+في خفض عدد اللي هو الإصابات بهذا الفيروس
+
+489
+00:36:30,370 --> 00:36:36,170
+كيف يحدث هذا الفيروس المرض، و ما دور المناعة فيه، الـ
+
+490
+00:36:36,170 --> 00:36:38,930
+virus infects the upper respiratory tract and then
+
+491
+00:36:38,930 --> 00:36:44,250
+spread through the blood and to infect the parotid
+
+492
+00:36:44,250 --> 00:36:48,810
+gland, testes, ovaries and pancreas، شوفوا الأعضاء
+
+493
+00:36:48,810 --> 00:36:52,610
+اللي بتصاب بهذا الفيروس، الـ parotid gland طبعا هي
+
+494
+00:36:52,610 --> 00:36:56,210
+اللي بنشوفها بسرعة، بينما في ال... في الـ male في
+
+495
+00:36:56,210 --> 00:36:59,830
+الذكور، الأطفال الذكور، تصل إلى الـ testes، و في
+
+496
+00:36:59,830 --> 00:37:04,010
+الإناث بتروح على بين على الـ ovaries، و ك common
+
+497
+00:37:04,010 --> 00:37:06,970
+part، اللي هو البنكرياس، and in some cases ممكن
+
+498
+00:37:06,970 --> 00:37:13,450
+تصل إلى الـ meninges، Alternatively، ممكن في plan B
+
+499
+00:37:13,450 --> 00:37:17,250
+للفيروس، الـ virus may ascend from the buccal mucosa
+
+500
+00:37:17,250 --> 00:37:21,490
+up to Stensen's duct to the parotid gland، يعني بدل 
+
+501
+00:37:21,490 --> 00:37:27,030
+ما يروح على الدم من نفس الفم بيصل إلى الـ parotoid
+
+502
+00:37:27,030 --> 00:37:32,960
+lifelong immunity occurs in a person who has
+
+503
+00:37:32,960 --> 00:37:36,820
+had the disease، برضه نفس الفكرة لمين؟ للميسلز،
+
+504
+00:37:36,820 --> 00:37:41,190
+كنا بيعطينا long life immunity. Mumps occurs only
+
+505
+00:37:41,190 --> 00:37:47,110
+once، وسواء كان أصاب الجهتين أو أصاب جهة واحدة إذا
+
+506
+00:37:47,110 --> 00:37:51,090
+أصاب جهة واحدة تمام، لن يحدث مرة أخرى في الجهة
+
+507
+00:37:51,090 --> 00:37:55,050
+التانية كما كانوا معتقدين عن كثير من الناس إذا هي
+
+508
+00:37:55,050 --> 00:38:00,070
+أصابة لمرة واحدة سواء كان في طرف أو في طرفين أو لم
+
+509
+00:38:00,070 --> 00:38:03,730
+يظهر عليه أعراض، لن يصاب مرة أخرى
+
+510
+00:38:06,090 --> 00:38:09,350
+Maternal antibody passes the placenta and provides
+
+511
+00:38:09,350 --> 00:38:12,550
+protection during the first six months of life،
+
+512
+00:38:12,550 --> 00:38:16,250
+إذا بيوفروا حماية لمدة تقريبا إيه؟ ست شهور، لحظة
+
+513
+00:38:16,250 --> 00:38:19,490
+أن الـ vaccine يا جماعة بنعطيها لمين احنا؟ على
+
+514
+00:38:19,490 --> 00:38:25,110
+خمسة عشر شهر، لإن الـ MMR هو أصلا موجود في الـ moms
+
+515
+00:38:27,330 --> 00:38:32,290
+طبعا هذه صورة لطفل بيورينا أن المنطقة اللي خدت
+
+516
+00:38:32,290 --> 00:38:36,430
+بتكون متورمة وقد يكون بيقولنا unilateral أو
+
+517
+00:38:36,430 --> 00:38:40,930
+bilateral. للأسف كان فينا يعني عادات سيئة للغاية
+
+518
+00:38:40,930 --> 00:38:47,070
+ومعتقدات ناتجة عن الجهل الكبير في الأطفال المصابين
+
+519
+00:38:47,070 --> 00:38:54,540
+كان يكتب لهم آيات قرآنية، يعني هو القرآن نعم يستشفى
+
+520
+00:38:54,540 --> 00:39:00,180
+بيه، لكن لا يُكتب وإنما يُقرأ على المريض. After an
+
+521
+00:39:00,180 --> 00:39:04,760
+incubation period of 18 to 21 days، إذا أطول شوية
+
+522
+00:39:04,760 --> 00:39:09,380
+من مين؟ من النيسل. A prodromal stage، وكلكم بتعرفوا
+
+523
+00:39:09,380 --> 00:39:12,340
+الآن الـ prodromal اللي هو الـ non-specific symptoms
+
+524
+00:39:12,340 --> 00:39:15,920
+of fever, malaise and anorexia is followed by
+
+525
+00:39:15,920 --> 00:39:19,490
+tender swelling of the parotid gland. Tender
+
+526
+00:39:19,490 --> 00:39:23,550
+swelling يعني انتفاخ مؤلم either unilateral or
+
+527
+00:39:23,550 --> 00:39:29,870
+bilateral. من الأشياء اللي بتخلي الأطباء يعرفوا أنه
+
+528
+00:39:29,870 --> 00:39:36,490
+الألم بيزيد when drinking citrus juices. لما بياخد
+
+529
+00:39:36,490 --> 00:39:40,490
+عصائر زي برتقال أو grapefruit أو كليمنتين أو أي من
+
+530
+00:39:40,490 --> 00:39:48,110
+المشروبات اللي هي الحمضيات، بيزيد اللي هو الألم. الـ
+
+531
+00:39:48,110 --> 00:39:50,990
+disease is typically... typically benign يعني
+
+532
+00:39:50,990 --> 00:39:57,630
+غالبا ما بي... يعني ما بيقتلش ال... ال... ال...
+
+533
+00:39:57,630 --> 00:40:00,730
+المريض، لكن في بعض الحالات احنا بيقولنا بيصل الـ
+
+534
+00:40:00,730 --> 00:40:04,370
+testis مظبوط، وبيصل ال... الـ ovary، وممكن يعمل
+
+535
+00:40:04,370 --> 00:40:08,670
+infertility خاصة عند الذكور. Benign and resolve
+
+536
+00:40:08,670 --> 00:40:11,430
+spontaneously within one week. Two complications
+
+537
+00:40:11,430 --> 00:40:14,630
+are significant. One is orchitis اللي هي التهاب
+
+538
+00:40:14,630 --> 00:40:19,110
+الخصية زي ما قلنا in post-perpetual male اللي هم
+
+539
+00:40:19,110 --> 00:40:24,450
+في فرحة البلوغ which if bilateral can result in
+
+540
+00:40:24,450 --> 00:40:28,250
+sterility. إذا كان في الخصيتين غالبا بيؤدي إلى اللي
+
+541
+00:40:28,250 --> 00:40:31,490
+هو العقم عند هؤلاء البالغين الجدد
+
+542
+00:40:34,100 --> 00:40:37,820
+الـ Unilateral Orchitis although quite painful
+
+543
+00:40:37,820 --> 00:40:41,700
+does not lead to sterility لأن الجهة التانية ما
+
+544
+00:40:41,700 --> 00:40:46,480
+زالت تعمل، وبتالي يعني ما يكونش فيه فقدان تام اللي
+
+545
+00:40:46,480 --> 00:40:50,840
+هو الحيوانات المنوية. The other complication is
+
+546
+00:40:50,840 --> 00:40:54,160
+meningitis. إذا فينا Orchitis وفينا meningitis. الـ
+
+547
+00:40:54,160 --> 00:40:58,460
+Orchitis كسب منها جسمين Unilateral و Bilateral. الـ
+
+548
+00:40:58,460 --> 00:41:01,540
+Bilateral الجون عنها بتسبب Sterility، أما الـ
+
+549
+00:41:01,540 --> 00:41:06,190
+Unilateral غالبا بتسببش. الـ complication التانية اللي هي
+
+550
+00:41:06,190 --> 00:41:09,710
+الـ meningitis which is usually benign, self
+
+551
+00:41:09,710 --> 00:41:14,670
+-limited and without sequel. غالبا بتؤديش إلى حتى
+
+552
+00:41:14,670 --> 00:41:17,070
+يعني بعض المضاعفات اللي بنشوفها في البكتيريا الـ
+
+553
+00:41:17,070 --> 00:41:19,970
+meningitis، بنشوفهاش في هذا النوع من الـ
+
+554
+00:41:19,970 --> 00:41:24,030
+meningitis. طبعا الـ mumps بالإضافة إلى الكوكساكي
+
+555
+00:41:24,030 --> 00:41:28,050
+فيروس والإيكو فيروس are the three most frequent
+
+556
+00:41:28,050 --> 00:41:33,190
+causes of viral وبين جثين aseptic meningitis. إيش
+
+557
+00:41:33,190 --> 00:41:37,190
+يعني أسبتك حكيناها قبل كده، إن العائل أو الكائن
+
+558
+00:41:37,190 --> 00:41:40,710
+المسبب لـ meningitis غير قابل للعزل بالطرق
+
+559
+00:41:40,710 --> 00:41:44,570
+التقليدية اللي تنهولها في المختبر؟ The widespread
+
+560
+00:41:44,570 --> 00:41:48,430
+of the vaccine in the United States had led to a
+
+561
+00:41:48,430 --> 00:41:51,170
+marked decrease in the incidence of mumps in
+
+562
+00:41:51,170 --> 00:41:54,190
+meningitis. طب واحنا عملنا أصلا marked decrease
+
+563
+00:41:54,190 --> 00:41:57,770
+في الـ mumps نفسه، صح؟ وبالتالي أكيد هيكون فيه
+
+564
+00:41:57,770 --> 00:42:01,390
+marked decrease إذا كان كل الحالات لم يتجاوزوا الـ
+
+565
+00:42:01,390 --> 00:42:06,610
+800، صح؟ أو 700، لم يتجاوزوا الـ 700 في عام 1997،
+
+566
+00:42:06,610 --> 00:42:11,290
+وبالتالي أكيد الـ meningitis هتكون أقل بقليل من ذلك
+
+567
+00:42:12,720 --> 00:42:17,860
+خلي بالك كتير عفوا. الـ laboratory diagnosis غالبا أقول
+
+568
+00:42:17,860 --> 00:42:23,380
+لكوا clinically. طبعا يولاترال أو بيلاترال، but
+
+569
+00:42:23,380 --> 00:42:26,000
+laboratory tests are available for confirmation
+
+570
+00:42:26,000 --> 00:42:29,560
+أنا للأسف يعني يحزني دائما أنه دائما أذكر هذا
+
+571
+00:42:29,560 --> 00:42:33,760
+الحقيقة أنه ليس لدينا حتى الـ influenza الـ
+
+572
+00:42:33,760 --> 00:42:36,080
+influenza اللي شفنا جداش مجموعة الفحوصات اللي لها
+
+573
+00:42:36,080 --> 00:42:39,620
+غير متوفر لها فحوصات. الـ measles غير متوفر لها
+
+574
+00:42:39,620 --> 00:42:44,080
+فحوصات. الـ mumps غير متوفر لها فحوصات. فقط clinical و
+
+575
+00:42:44,080 --> 00:42:47,350
+الـ clinical يا جماعة ممكن بعض الأحيان تشابه كثير
+
+576
+00:42:47,350 --> 00:42:51,410
+من الأعراض أو لا تظهر الأعراض كاملة full يعني
+
+577
+00:42:51,410 --> 00:42:55,710
+وبالتالي بيصير فينا misdiagnosis لبعض الحالات. هذا الـ
+
+578
+00:42:55,710 --> 00:43:00,070
+misdiagnosis لما أنا أقول لمريض عنده mumps روح روح
+
+579
+00:43:00,070 --> 00:43:04,330
+عده وما عنكاش حاجة، هذا التهاب بكتيري أو كده، مش هذا
+
+580
+00:43:04,330 --> 00:43:08,410
+هيكون مصدر عدوى للآخرين، لكن لو كان شخصناه صح في
+
+581
+00:43:08,410 --> 00:43:11,890
+الغالب هنعزله عن الآخرين وناخد الاحتياطات اللازمة
+
+582
+00:43:11,890 --> 00:43:19,040
+لذلك الفيروس يمكن أن يكون مقفل في المثلجة من صليب أو
+
+583
+00:43:19,040 --> 00:43:24,500
+مخلوق روحاني أو روحاني كمان. ممكن نكشف قبل قليل
+
+584
+00:43:24,500 --> 00:43:27,600
+في أول لوحة أنه في عندنا سوليوب والـ antigen. نكشف
+
+585
+00:43:27,600 --> 00:43:34,060
+عنه بإي اللي هو complement fixation test. ممكن كمان
+
+586
+00:43:34,060 --> 00:43:39,430
+في skin test. عارفين الـ skin test أنه نحقن المريض
+
+587
+00:43:39,430 --> 00:43:42,930
+intradermally، وبنشوف إذا كان فيه أنه صار reaction
+
+588
+00:43:42,930 --> 00:43:49,710
+بعد 24-48 ساعة. The mumps skin test is widely used to
+
+589
+00:43:49,710 --> 00:43:53,630
+determine whether patients cell mediated immunity
+
+590
+00:43:53,630 --> 00:43:57,410
+is competent. الآن هذا الفحص بطل يستخدموه لإن مافيش
+
+591
+00:43:57,410 --> 00:44:02,230
+إننا mumps يعني بكمية كبيرة، لكن لازال الفحص موجود
+
+592
+00:44:02,230 --> 00:44:07,020
+يعني واحد عندنا بيه مرض كتير ما لهوش علاقة بالكلام
+
+593
+00:44:07,020 --> 00:44:11,000
+اللي بنحكيه الآن احنا، بنبقى مرض كتير، بنعرف أنه
+
+594
+00:44:11,000 --> 00:44:14,780
+هل لأنه cell-mediated immunity deficiency، بنعمله
+
+595
+00:44:14,780 --> 00:44:19,520
+mumps test، mumps test، مش هو مطعم، لازم يطلع عيش
+
+596
+00:44:19,520 --> 00:44:22,940
+المفروض positive، صح؟ إذا بيطلع... إذا... إذا
+
+597
+00:44:22,940 --> 00:44:25,700
+بيطلع positive، بيكون مناعته منيحة، إذا بيطلع
+
+598
+00:44:25,700 --> 00:44:28,660
+negative، معناه الحاجة أنه ما عندهوش أصلا هو مناعة،
+
+599
+00:44:28,660 --> 00:44:33,680
+تمام؟ وكانوا باستخداموه ككاشف عن الـ cell mediated
+
+600
+00:44:33,680 --> 00:44:36,540
+image. والمرة الجاية إن شاء الله بنكمل الأجزاء
+
+601
+00:44:36,540 --> 00:44:36,980
+الباقية
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Y0-QuWrz92s_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Y0-QuWrz92s_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b14beb6aa7c0ffbb9fa0d00b9a251cba1196597f
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Y0-QuWrz92s_raw.srt
@@ -0,0 +1,2428 @@
+1
+00:00:21,360 --> 00:00:26,560
+بسم الله الرحمن الرحيم نكمل ان شاء الله ال .. ال
+
+2
+00:00:26,560 --> 00:00:30,200
+RNA enveloped viruses و هنتكلم انهم شعر البعض ال
+
+3
+00:00:30,200 --> 00:00:33,360
+myoxic viruses نسترجع بعض المعلومات اللي ذكرناها
+
+4
+00:00:33,360 --> 00:00:37,240
+المحاضرة السابقة عن هذه المجموعة اللي تحدثنا انها
+
+5
+00:00:37,240 --> 00:00:40,960
+تشبه إلى حد كبير ال orthomyoxic viruses لكن في وجه
+
+6
+00:00:40,960 --> 00:00:46,560
+اختلاف رئيسي على وهو عدم موجود جنوم مقطع لكن
+
+7
+00:00:46,560 --> 00:00:49,120
+الجنوم التنين بيشتركوا بينهم single
+
+8
+00:00:52,010 --> 00:00:55,450
+والتانية بيحملوا معاهم RNA dependent RNA
+
+9
+00:00:55,450 --> 00:01:00,150
+polymerase والنوجينوه تبعهم not infectious يعني
+
+10
+00:01:00,150 --> 00:01:04,470
+غير معضي بيحتوي على spikes أيضا بيشبهوا ال spikes
+
+11
+00:01:04,470 --> 00:01:09,690
+تبع ال orthomox viruses لكن قد تحتوي علىهيم
+
+12
+00:01:09,690 --> 00:01:13,550
+أجلوتينين و نيرو أميديز on one single spikes وفي
+
+13
+00:01:13,550 --> 00:01:16,510
+بالإضافة إلى الهيم أجلوتينين و نيرو أميديز حاجة
+
+14
+00:01:16,510 --> 00:01:20,510
+اسمها fusion protein و حاجة اسمها كمان hemolytic
+
+15
+00:01:20,510 --> 00:01:23,710
+activity إذا انت مر معانا في اللي هو ال orthomoxy
+
+16
+00:01:23,710 --> 00:01:28,640
+virusesوبنقسم احنا الفيروسات ال .. ال .. ال .. ال
+
+17
+00:01:28,640 --> 00:01:31,640
+.. ال viridae وكلمة viridae معناها عائلة لما نسمع
+
+18
+00:01:31,640 --> 00:01:35,820
+كلمة paramoxiviridae يبقى الشق ال .. ال .. ال ..
+
+19
+00:01:35,820 --> 00:01:40,740
+الاخير في الكلمة viridae تعني عائلة على غرار اللي
+
+20
+00:01:40,740 --> 00:01:42,720
+بتذكره في ال bacteriology كنا نقول
+
+21
+00:01:42,720 --> 00:01:48,300
+enterobacteriaceae family micrococciaceae family
+
+22
+00:01:48,300 --> 00:01:52,570
+فال viridae هنا family أيضاوبتنقسم إلى ثلاثة
+
+23
+00:01:52,570 --> 00:01:55,810
+viruses اللي هم الـ Paramexivirus والموربيليفيروس
+
+24
+00:01:55,810 --> 00:02:00,700
+والنيوموفيروسالـ Paramyxovirus بيشمل الـ Mumps و
+
+25
+00:02:00,700 --> 00:02:04,040
+الـ Parainfluenza وهي أبعاها أربعة سلالات من واحد
+
+26
+00:02:04,040 --> 00:02:08,220
+لأربعة و الموربيليفيروس بيشمل الـ Measles virus
+
+27
+00:02:08,220 --> 00:02:12,420
+اللي هو بيسموه Rubiola و بنميزه عن الربلة الربلة
+
+28
+00:02:12,420 --> 00:02:16,360
+اللي هي ال German Measles ال Nemovirus من اسمه
+
+29
+00:02:16,360 --> 00:02:19,060
+بيشمل فقط اللي هو ال Respiratory syncytial virus
+
+30
+00:02:19,060 --> 00:02:21,580
+اللي بيعمل و انها Pulmonary infection
+
+31
+00:02:23,990 --> 00:02:28,190
+ولمّا جينا طلعنا على الاربع فيروسات اللي شملوا في
+
+32
+00:02:28,190 --> 00:02:33,690
+هذه المجموعة، بنلاقي ان كلهم بيحتوي على Fusion
+
+33
+00:02:33,690 --> 00:02:37,990
+Protein في العمود الأخيرلكن مش كلهم بيحتوي على
+
+34
+00:02:37,990 --> 00:02:40,790
+نيرو اميديس فقط اتنين هما ال mumps virus و ال para
+
+35
+00:02:40,790 --> 00:02:44,030
+influenza virus و الوحيد اللي مابيحتويش على
+
+36
+00:02:44,030 --> 00:02:48,010
+hemagglutinin هو ال respiratory syncytial virus
+
+37
+00:02:48,010 --> 00:02:51,890
+طبعا ال respiratory syncytial virus شهرته بان هو
+
+38
+00:02:51,890 --> 00:02:54,770
+من اللي بيعمل syncytia اللي هي ال multi nucleated
+
+39
+00:02:54,770 --> 00:02:55,750
+giant cell
+
+40
+00:02:59,030 --> 00:03:02,390
+بدأنا بحديث عن اللي هو ال missiles virus وقلنا انه
+
+41
+00:03:02,390 --> 00:03:05,650
+ال .. ال .. ال missiles هو disease of childhood
+
+42
+00:03:05,650 --> 00:03:09,130
+غالبا بيصيب أمراض او .. او هو من مرض .. مرض من
+
+43
+00:03:09,130 --> 00:03:14,050
+أمراض الطفولة بينتقل عبر ال respiratory tract و
+
+44
+00:03:14,050 --> 00:03:17,850
+بسبب انه حاسبه maculopapular rash وال rash هنا ..
+
+45
+00:03:17,850 --> 00:03:22,230
+هنا بيبدأ من الفم من الداخل من اللسان ثم إلى الوجه
+
+46
+00:03:22,230 --> 00:03:28,730
+ثم إلى باقي الجسدطبعا كان في مثل زمان بيقول ما
+
+47
+00:03:28,730 --> 00:03:34,210
+حياة إلا بعد حصبة، إيش يعني؟ يعني كانوا الناس يعني
+
+48
+00:03:34,210 --> 00:03:39,250
+مدركين حجم المخاطر المحدقة بأبناءهم من اللي هو
+
+49
+00:03:39,250 --> 00:03:43,370
+المرض الحصبة وبتالي مايعتبروش إن ابنهم هيبقى على
+
+50
+00:03:43,370 --> 00:03:48,000
+قيد الحياة ويكمل المسيرة إلا إيه ده؟نجا من مرض
+
+51
+00:03:48,000 --> 00:03:51,860
+اللي هو الحصبة دليل على إيه؟ على إنه كانت بالفعل
+
+52
+00:03:51,860 --> 00:03:57,300
+في السابق تشكل خطر كبير على الأطفال وهو worldwide
+
+53
+00:03:57,300 --> 00:04:01,300
+disease مرض يعني عالمي بيصيب كل سكان العالم
+
+54
+00:04:04,050 --> 00:04:08,370
+الجينوم بقرة بيكسب فيروس يعني negative sense
+
+55
+00:04:08,370 --> 00:04:13,890
+single-stranded RNA ومعها قلنا كمان مرة اللي هو ال
+
+56
+00:04:13,890 --> 00:04:17,630
+RNA independent RNA polymerase بيحتوي على ال
+
+57
+00:04:17,630 --> 00:04:22,250
+missiles فيروس على him agglutinating activity وعلى
+
+58
+00:04:22,250 --> 00:04:26,160
+cell fusion زادHemolytic activity إذا فيه انه two
+
+59
+00:04:26,160 --> 00:04:30,260
+spikes واحد بيشمل اللي هو ال heme agglutination
+
+60
+00:04:30,260 --> 00:04:34,100
+والتاني بيشمل two function fusion and hemolytic
+
+61
+00:04:34,100 --> 00:04:37,380
+activity it has a single serotype وهذا قلنا سر
+
+62
+00:04:37,380 --> 00:04:41,100
+نجاح ان احنا قامنا بفكسينة وان ال human are the
+
+63
+00:04:41,100 --> 00:04:45,680
+only natural host وهذا أيضا اضافة لماذا نجحنا في
+
+64
+00:04:45,680 --> 00:04:46,860
+إحداث الفكسينة
+
+65
+00:04:49,710 --> 00:04:52,190
+بينتقل جميعا عبر ال respiratory track من خلال ال
+
+66
+00:04:52,190 --> 00:04:56,150
+respiratory droplets ال incubation .. ال ايه؟ عفوا
+
+67
+00:04:56,150 --> 00:04:59,890
+ال outbreaks تبعته تحدث من كل ما بين سنتين لكل
+
+68
+00:04:59,890 --> 00:05:04,670
+ثلاث سنوات ليش مش كل سنة يعني؟ لما بيتجمع عدد
+
+69
+00:05:04,670 --> 00:05:09,190
+أطفال عدد أطفال ما عندهم مش مناعة بنسميهم
+
+70
+00:05:09,190 --> 00:05:13,390
+susceptable يعني قابلين لمين للإصابة طب هل هناك
+
+71
+00:05:13,390 --> 00:05:17,630
+أماكن في العالم لم يصلها ال vaccination بشكل كافي؟
+
+72
+00:05:18,290 --> 00:05:22,550
+لكم تتخيلوا أمريكا .. أمريكا من الدول .. مش من
+
+73
+00:05:22,550 --> 00:05:26,190
+الدول .. هي أكثر دولة متقدمة تقنيا و صحيا ممكن في
+
+74
+00:05:26,190 --> 00:05:32,900
+.. على مستوى العالملكن داخل هذه الدولة هناك عقليات
+
+75
+00:05:32,900 --> 00:05:39,560
+و أرقيات تمام بيجتمعوا مع بعض مثلا مابتجوزوش من
+
+76
+00:05:39,560 --> 00:05:44,080
+خارج إطار المجموعة، اللي هم معتقدات دينية معينة
+
+77
+00:05:44,080 --> 00:05:47,260
+بتعتقدوا ان ال vaccination على سبيل المثال هو شيء
+
+78
+00:05:47,260 --> 00:05:50,540
+مش مطلوب و قد يضر أبناءهم وبتالي مابتطعموش،
+
+79
+00:05:50,540 --> 00:05:54,020
+بتحالوا على النظام الصحي، بتحالوا عليه بأي طريقة
+
+80
+00:05:54,020 --> 00:05:59,640
+مابتطعموشفكل فترة وفترة بيصير فيه انتشار أوبئة بين
+
+81
+00:05:59,640 --> 00:06:02,420
+هذه الفياترات على الرغم من أنها موجودة في دول
+
+82
+00:06:02,420 --> 00:06:06,100
+متقدمة فدعا بالك الآن في دول يعني غير متطورة أو
+
+83
+00:06:06,100 --> 00:06:10,520
+مقنامية او احنا بنسميها دول عالم الثالث تعبير لطيف
+
+84
+00:06:10,520 --> 00:06:13,860
+عن التخلف اللي عاشها فيه تمام؟ لأن مافيش بعد
+
+85
+00:06:13,860 --> 00:06:19,140
+التالت إشي فبالتالي هي الأخيرة وهذه الدول تتميز
+
+86
+00:06:19,140 --> 00:06:23,050
+بشغل تاني ان في عندها mal nourishmentسوق تغذية
+
+87
+00:06:23,050 --> 00:06:26,690
+ولكن وما تتخيلوا ما يحدث الأن في أخواننا في اليمن
+
+88
+00:06:26,690 --> 00:06:30,610
+وفي سوريا يعني هناك صور يعني بتخشعوا اللي أبدا
+
+89
+00:06:30,610 --> 00:06:33,510
+تخرج من اليمن في الفترة الحالية خاصة مع اللي هو
+
+90
+00:06:33,510 --> 00:06:39,810
+الحرب وانتشار مرض أيضا الكوليرة فقر سوق تغذية
+
+91
+00:06:42,260 --> 00:06:47,280
+الخطورة الأولويات بتغير خطورة المعنى أنه ممكن
+
+92
+00:06:47,280 --> 00:06:50,680
+الأمة ماتقدرش تتصل أصلا لمركز الرعاية الصحية عشان
+
+93
+00:06:50,680 --> 00:06:55,120
+الطعم المولود مظبوط الأولويات بتصير للجرحة و
+
+94
+00:06:55,120 --> 00:06:58,640
+للقتلة و للدفن الجثث وبتالي الأولويات بتتغير
+
+95
+00:06:58,640 --> 00:07:03,300
+فدائما و أبدا مافيش 100% coverage لل vaccination
+
+96
+00:07:03,300 --> 00:07:09,180
+في كثير من اللي هموبالتالي كل فترة من سنتين لتلاتة
+
+97
+00:07:09,180 --> 00:07:15,420
+بيحدث outbreak في تلك المناطق واحنا اتفقنا وناقشنا
+
+98
+00:07:15,420 --> 00:07:24,180
+قبلها قضية الحدوث وباء لابد ان يكون مجموع السكان
+
+99
+00:07:24,180 --> 00:07:27,400
+المطعمين
+
+100
+00:07:27,400 --> 00:07:31,290
+او الذين لايمتلكون مناعةضد الميكروب وان كان سواء
+
+101
+00:07:31,290 --> 00:07:36,230
+كان فيروس او كان بكتيريا لازم يكون عدد كبير جدا من
+
+102
+00:07:36,230 --> 00:07:40,130
+السكان غير مطعمين واحنا بنقول ان الان المرحلة
+
+103
+00:07:40,130 --> 00:07:43,870
+مهيئة على سبيل المثال لحدوث وباء عالمي بالجدري،
+
+104
+00:07:43,870 --> 00:07:48,990
+ليش؟لأنه توقفنا عن تطايم ولا يرد إصابات في الوقت
+
+105
+00:07:48,990 --> 00:07:52,110
+الحالي بالجدري وبالتالي في يوم من الأيام لو قرر
+
+106
+00:07:52,110 --> 00:07:56,050
+أحد الناس أن يقوم بحرب بيولوجية أو إرهاب بيولوجي
+
+107
+00:07:56,050 --> 00:07:59,890
+وينشر الفيروسات اللي هي الآن موجودة في مختبرات
+
+108
+00:07:59,890 --> 00:08:04,620
+دولة المتحدة الأمريكية وروسيافهيحدث جائحة عالمية
+
+109
+00:08:04,620 --> 00:08:10,420
+لأن السكان الان مؤهلين ليش مؤهلين؟ ليس لديهم مناعة
+
+110
+00:08:10,420 --> 00:08:14,840
+او antibodies او vaccination مسبق ضد هذا الموضوع
+
+111
+00:08:14,840 --> 00:08:20,340
+وهذا ثبت حقيقة في كل .. تاريخيا في كل المناطق اللي
+
+112
+00:08:20,340 --> 00:08:25,540
+انتقل اليها مرض لم يكن موجود في السابق كان يحدث
+
+113
+00:08:25,540 --> 00:08:31,120
+اوبياء devastating منها ال missilesفي الف وتمنية
+
+114
+00:08:31,120 --> 00:08:39,100
+في القرن التسعتاش بعض السياح عارفوا Hawaii Hawaii
+
+115
+00:08:39,100 --> 00:08:44,760
+جزر حلوة وجميلة فصاروا يزوروها زوار أو السياح ولم
+
+116
+00:08:44,760 --> 00:08:47,840
+يكن السكان هناك قد عارفوا مرة بالحصبة من قبل
+
+117
+00:08:47,840 --> 00:08:52,860
+فأجتمعوا مرة بالحصبة مع من؟ مع السياح فأحدث لديهم
+
+118
+00:08:52,860 --> 00:08:58,020
+لدى السكان الأصليين devastating epidemicفهذه نقطة
+
+119
+00:08:58,020 --> 00:09:00,800
+ياريت نكون منتبهين إلها، إنه مش معناه الحاجة إن
+
+120
+00:09:00,800 --> 00:09:05,640
+المرض بطل يحدث إنه خلاص انتهى و لن يحدث، قد يعود
+
+121
+00:09:05,640 --> 00:09:10,900
+مرة أخرى إما من خلال deliberate، يعني حاجة متعمدة
+
+122
+00:09:10,900 --> 00:09:17,340
+تمام، أو من خلال تغير أنتجيني للفيروس أو اللي هو
+
+123
+00:09:17,340 --> 00:09:23,690
+ال microنرجع لموضوعنا، جوانب تحدث في كل العالم و
+
+124
+00:09:23,690 --> 00:09:29,600
+بتحدث في حالة تفشيات من سنتين لتلت سنواتالـ attack
+
+125
+00:09:29,600 --> 00:09:33,600
+rate واحدة من أعلى للـ viral disease بمعنى إن لو
+
+126
+00:09:33,600 --> 00:09:38,760
+كان طفل مصاب وقعد مجموعة، كل المجموعة يجب أن يحدث
+
+127
+00:09:38,760 --> 00:09:43,420
+لديها هذا ال disease، مش الكل أو مش البعض ينجو،
+
+128
+00:09:43,420 --> 00:09:47,440
+البعض الأخر لاينجو، الكل يصاب بالعراب، ثم بعد ذلك
+
+129
+00:09:47,440 --> 00:09:50,180
+قد يموت أشخاص وينجوا أشخاص
+
+130
+00:09:52,750 --> 00:09:55,510
+هذه يمكن هي الجملة الأخيرة اللي حكيناها أنه في الف
+
+131
+00:09:55,510 --> 00:09:59,470
+و تبان مية جونا devastating worldwide epidemic
+
+132
+00:09:59,470 --> 00:10:07,470
+أكار في هواي لإنه ماكان عندهم منعه وذكرنا كلمة mal
+
+133
+00:10:07,470 --> 00:10:11,830
+nourished اللي هم سوق التخزيه برضه كمانلو جينا
+
+134
+00:10:11,830 --> 00:10:17,350
+قارننا نسبة الناس او حدث المرض في الأطفال ذوي
+
+135
+00:10:17,350 --> 00:10:20,710
+التخذية الجيدة بالمقارنة مع ذوي التخذية السيئة
+
+136
+00:10:20,710 --> 00:10:25,370
+سنجد ان حدث المرض عالية جدا و أحد الأشياء اللي
+
+137
+00:10:25,370 --> 00:10:29,170
+انتبه إلى الأطباء في ذاك الوقت انه vitamin A
+
+138
+00:10:29,170 --> 00:10:34,940
+deficiency بالذات له تأثير كبير لذلك أدخلهالـ
+
+139
+00:10:34,940 --> 00:10:40,040
+Vitamin A ضمن الغذاء تبع المرضى تبعهم اللي هم ال
+
+140
+00:10:40,040 --> 00:10:43,440
+missiles حتى يحسنه من ال outcome ل ال disease
+
+141
+00:10:43,440 --> 00:10:46,900
+المرضى
+
+142
+00:10:46,900 --> 00:10:50,540
+الجهاز المنعه تبعهم منخفض زي مرضى ال aids ايضا لو
+
+143
+00:10:50,540 --> 00:10:53,920
+أصيبه بيه ال missiles غالبا بتكون ال infection
+
+144
+00:10:53,920 --> 00:11:01,130
+fatal يعني قاتلة هذا مش هلاشعلى انه جهاز المنع ..
+
+145
+00:11:01,130 --> 00:11:05,950
+احنا كنا نقول جهاز المنع له دور كبير في إيش؟ في
+
+146
+00:11:05,950 --> 00:11:11,390
+إحداث الأعراض، في هذه الحالة عكس ذلك تماماً، جهاز
+
+147
+00:11:11,390 --> 00:11:16,370
+المنع غير متهم في أن هو المسئول عن الأعراض، ليش؟
+
+148
+00:11:16,370 --> 00:11:21,360
+مريض ال aidsماعندوش مناعة أساسا، وبالتالي بنقول إن
+
+149
+00:11:21,360 --> 00:11:26,640
+المبارض بيحدث عنده symptoms devastating وممكن تودي
+
+150
+00:11:26,640 --> 00:11:29,400
+إلى الوفاة، ده اللي علامة مجازة المناعة، لم يكن هو
+
+151
+00:11:29,400 --> 00:11:35,420
+المتهم في هذا الأمر البدء ال pathogenesis and
+
+152
+00:11:35,420 --> 00:11:39,990
+immunityبعد ما الإصابة بالـ Upper Respiratory
+
+153
+00:11:39,990 --> 00:11:43,270
+Tract، الفيروس بيصل إلى الدم، وبعدين بيروح على
+
+154
+00:11:43,270 --> 00:11:46,730
+Reticular Endothelial System، ومن هناك يتكاثر مرة
+
+155
+00:11:46,730 --> 00:11:52,430
+أخرى، وبعدين بينتقل من الدم إلى الجلد، إذا خلينا
+
+156
+00:11:52,430 --> 00:11:57,310
+نقول إن الـ Final Destination أو الجوجهة الأخيرة
+
+157
+00:11:57,310 --> 00:12:04,130
+للفيروس هي الجلد، وهناكبيتكاثر في ال ال ال ال ال
+
+158
+00:12:04,130 --> 00:12:04,630
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+159
+00:12:04,630 --> 00:12:05,150
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+160
+00:12:05,150 --> 00:12:06,230
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+161
+00:12:06,230 --> 00:12:07,270
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+162
+00:12:07,270 --> 00:12:16,410
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+163
+00:12:16,410 --> 00:12:17,090
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+164
+00:12:17,090 --> 00:12:18,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+165
+00:12:18,490 --> 00:12:18,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+166
+00:12:18,490 --> 00:12:18,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+167
+00:12:18,490 --> 00:12:18,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+168
+00:12:18,490 --> 00:12:18,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+169
+00:12:18,490 --> 00:12:18,490
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+170
+00:12:18,490 --> 00:12:18,530
+ال ال ال ال ال ال ال ال ال
+
+171
+00:12:26,990 --> 00:12:31,070
+لما احنا اقتهمناها انها بتكون بدور سلبي، اقتهمناها
+
+172
+00:12:31,070 --> 00:12:35,850
+بهذا الدور لأنه بينتج عنه أعراض سلبية، لكن واقع
+
+173
+00:12:35,850 --> 00:12:41,310
+الأمر المسئول عن إيقاف مشاطر الفيروس وتكاثره، هم
+
+174
+00:12:41,310 --> 00:12:45,170
+اتنين في هذا الحالة، ال antibody بتفاعل مع ال free
+
+175
+00:12:45,170 --> 00:12:48,710
+virus اللي هو اتكاثر وطلع من الخلاياو ال site
+
+176
+00:12:48,710 --> 00:12:52,570
+toxicity cell بتأثر على ال virally infected cell
+
+177
+00:12:52,570 --> 00:12:56,930
+وبتالي اتنين بيحيطوا بالفيروس و بيقللوا من إمكانية
+
+178
+00:12:56,930 --> 00:12:59,930
+انتشاره انتوا عارفين ان الأعارض اللي ماتظهر عند
+
+179
+00:12:59,930 --> 00:13:04,270
+مريض الحصبه بيكون already هو غير معدي يعني متى
+
+180
+00:13:04,270 --> 00:13:08,290
+بيكون معدي؟ قبل ما تظهر عليه في فترة ال incubation
+
+181
+00:13:08,290 --> 00:13:12,370
+period و ال prodromal إذا ظهر الرش على دسمه بيبطل
+
+182
+00:13:12,370 --> 00:13:15,330
+يكون معدي معناه الحاجة ان ال incubation period
+
+183
+00:13:15,330 --> 00:13:21,840
+فيها طويلة شويةهذا الطول بيخلي الجسم يتفاعل
+
+184
+00:13:21,840 --> 00:13:24,980
+مناعيًا ينتج أجسام مضادة لما نقول عشر إلى أربعاشر
+
+185
+00:13:24,980 --> 00:13:28,580
+يوم، incubation period، إيش معناه الحكي؟ معناه
+
+186
+00:13:28,580 --> 00:13:31,880
+الحكي إنه أنا أعطيت فرصة للجسم إنه أصلا هي الفترة
+
+187
+00:13:31,880 --> 00:13:37,180
+اللازمة لتكوين أجسام مضادة من عشر إلى أربعاشر يوم،
+
+188
+00:13:37,180 --> 00:13:41,100
+إذا بالفعل by the time symptoms appear غالبا بيكون
+
+189
+00:13:41,100 --> 00:13:44,480
+ال virus صار فيه له subsidize أو صار له
+
+190
+00:13:44,480 --> 00:13:46,320
+neutralization بشكل كبير
+
+191
+00:13:48,760 --> 00:13:52,080
+ممكن يحدث كمان antibody-mediated vasculitis التهاب
+
+192
+00:13:52,080 --> 00:13:56,960
+القوية الدموية ناتج عن ارتباط الانتجين بالانتجين
+
+193
+00:13:56,960 --> 00:13:58,640
+بالانتجين بالانتجين بالانتجين بالانتجين بالانتجين
+
+194
+00:13:58,640 --> 00:13:59,260
+بالانتجن بالانتجن بالانتجن بالانتجن بالانتجن
+
+195
+00:13:59,260 --> 00:14:00,020
+بالانتجن بالانتجن بالانتجن بالانتجن بالانتجن
+
+196
+00:14:00,020 --> 00:14:01,220
+بالانتجن بالانتجن بالانتجن بالانتجن بالانتجن
+
+197
+00:14:01,220 --> 00:14:01,280
+بالانتجن بالانتجن بالانتجن بالانتجن بالانتجن
+
+198
+00:14:01,280 --> 00:14:04,140
+بالانتجن بالانتجن بالانتجن بالانتجن بالانتجن
+
+199
+00:14:04,140 --> 00:14:08,540
+بالانتجن بالانتجن بالانتجن بالانتجن بالانتجن
+
+200
+00:14:08,540 --> 00:14:12,580
+بالانتجن
+
+201
+00:14:12,580 --> 00:14:18,860
+بالالـ lesions اللي بتحدث في المريض بنلاقي فيها
+
+202
+00:14:18,860 --> 00:14:25,620
+الـ multinucleated joint cells الدزيز بيوفر long
+
+203
+00:14:25,620 --> 00:14:30,180
+life immunity للمصابين اللي recovered من هذا
+
+204
+00:14:30,180 --> 00:14:35,200
+الدزيزعلى الرغم من ان ال IGG بيلعب دور كبير جدا في
+
+205
+00:14:35,200 --> 00:14:39,620
+المناعة ضد ال missiles إلا أن الدور الأكبر يا
+
+206
+00:14:39,620 --> 00:14:42,980
+جماعة لمن؟ لـ cell-mediated immunity عشان هي كده
+
+207
+00:14:42,980 --> 00:14:45,960
+مرضى ال HIV قلنا لكم لو أصيبه بصير عنده
+
+208
+00:14:45,960 --> 00:14:51,780
+devastating missiles و ممكن يموت في حاجة مميزة جدا
+
+209
+00:14:51,780 --> 00:14:57,970
+في مرضى ال missilesفي اللسان تبعهم و تعتبر علينا
+
+210
+00:14:57,970 --> 00:15:02,810
+diagnostic بمعنى ان الطبيب إذا شافها هو ليس بحاجة
+
+211
+00:15:02,810 --> 00:15:08,270
+إلى ان يعمل confirmatory laboratory test اسم ال
+
+212
+00:15:08,270 --> 00:15:13,210
+finding coplic spot لو طلعنا على الصورة اللي
+
+213
+00:15:13,210 --> 00:15:17,650
+أمامنا هنا بنلاقي في slightly pinkish spots
+
+214
+00:15:21,410 --> 00:15:25,650
+مش اللون أبيض أو مش .. يعني اللون خلينا نقول زائد
+
+215
+00:15:25,650 --> 00:15:31,890
+عن زهري هنا وفي عندي هنا white spot شايفينها white
+
+216
+00:15:31,890 --> 00:15:34,290
+spot أكيد في ال .. في ال presentation اللي هتكون
+
+217
+00:15:34,290 --> 00:15:38,870
+موجودة معاكم هتكون الصورة أوضح هذا ال finding اسمه
+
+218
+00:15:38,870 --> 00:15:42,330
+coplic spot هذا ال coplic spot وجودها يعني
+
+219
+00:15:42,330 --> 00:15:47,720
+missiles ففي ارتباط بين اتتين اتتينبعد كام يوم
+
+220
+00:15:47,720 --> 00:15:50,620
+بيبدأ ال maculopapular rash اللي قلنا عنه هو
+
+221
+00:15:50,620 --> 00:15:55,920
+الأحمرار موجود على الوجه و بينزل تدريجيا على الجسم
+
+222
+00:15:55,920 --> 00:15:59,360
+و ال lower extremities و بصيب اللي ورا حتي اليد
+
+223
+00:15:59,360 --> 00:16:04,390
+حتى و الرجلينThe rash develops a brownish hue
+
+224
+00:16:04,390 --> 00:16:11,670
+several days later بعد عدة أيام بيصير في لون
+
+225
+00:16:11,670 --> 00:16:18,650
+بني خفيف و بيختفي و بيذوي تدريجيا حتى يعود الجلد
+
+226
+00:16:18,650 --> 00:16:23,890
+مرة أخرى بنفس اللوحة الاخيرة في هذه اللوحة بتقول
+
+227
+00:16:23,890 --> 00:16:28,190
+ان ال complication للميسلز can be quite severe
+
+228
+00:16:30,020 --> 00:16:33,100
+مضاعفة .. إيش من مضاعفتها؟ من مضاعفتها
+
+229
+00:16:33,100 --> 00:16:33,920
+Encephalitis
+
+230
+00:16:36,800 --> 00:16:43,700
+بتحدث بنسبة او ب rate تمام واحد لكل الف حالة من ال
+
+231
+00:16:43,700 --> 00:16:47,600
+missiles يعني منكون الف مصاب بيحدث لنا حالة واحدة
+
+232
+00:16:47,600 --> 00:16:52,680
+encephalitis الان تعالى نطلع سيبولنا الان من الرقم
+
+233
+00:16:52,680 --> 00:16:57,280
+الواحد الواحد ما هو من الف بيصير لنا رقم كبير الان
+
+234
+00:16:57,280 --> 00:17:01,700
+من هذا الرقم اللي هم عندهم encephalitis عشرة في
+
+235
+00:17:01,700 --> 00:17:07,970
+المية بيموتوا10% منهم بيموتوا و 40% منهم بيصير
+
+236
+00:17:07,970 --> 00:17:13,470
+عندهممش mental retardation، خدنا نسميها permanent
+
+237
+00:17:13,470 --> 00:17:18,910
+sequela، يعني أثار دائمة، إعاقات دائمة مثل
+
+238
+00:17:18,910 --> 00:17:24,110
+deafness، فقدان السماع أو mental retardation، إذا
+
+239
+00:17:24,110 --> 00:17:28,370
+الـEncephalitis اللي ناجي معاها الميسلز خطيرة
+
+240
+00:17:28,370 --> 00:17:32,770
+ونسبة القتل فيها عالية ونسبة اللي هو قلنا كمان مرة
+
+241
+00:17:32,770 --> 00:17:39,020
+ال mental و ال deafness فيها أيضا عاليةإضافة لما
+
+242
+00:17:39,020 --> 00:17:44,520
+ذكرنا من complication الميسلز ما هي جون عنها
+
+243
+00:17:44,520 --> 00:17:47,820
+primarily وين بتصيب؟ في ال lungs صح أو لا؟ ممكن
+
+244
+00:17:47,820 --> 00:17:50,680
+تعمل هي نفسها نيومونيا زي ال influenza أو زي ما
+
+245
+00:17:50,680 --> 00:17:52,980
+قلت لك بالظبط ال influenza إما هي نفسها بتعمل
+
+246
+00:17:52,980 --> 00:17:58,200
+نيومونيا أو secondary نيومونيا bacterial نيومونيا
+
+247
+00:17:58,200 --> 00:18:01,580
+وهذا اللي بيزيد كمان مرة بالنسبة للوفيات في هذا
+
+248
+00:18:01,580 --> 00:18:05,660
+المرض الخطير أيضا
+
+249
+00:18:06,210 --> 00:18:09,870
+يولد لدينا إمكانية إصابة أطفال بيوتايتس ميديا
+
+250
+00:18:09,870 --> 00:18:13,270
+الاتهاب الأذن الوسطى ناتج عن اللي هو هذا ال virus
+
+251
+00:18:13,270 --> 00:18:17,870
+وفي مرض خطير جدا جدا و غريب في نفس الوقت لإنه لا
+
+252
+00:18:17,870 --> 00:18:22,070
+يصيب الطفل اليوم المصاب وإنما يصيبه بعد عدة سنوات
+
+253
+00:18:22,070 --> 00:18:28,140
+من إصابته بيه اللي هو ال diseaseاسمه sub acute
+
+254
+00:18:28,140 --> 00:18:34,320
+sclerosing panencephalitis أو SSPE كمان مرة sub
+
+255
+00:18:34,320 --> 00:18:40,340
+acute sclerosing panencephalitis و rare لكن fatal
+
+256
+00:18:40,340 --> 00:18:44,300
+disease قاتل of the central nervous system that
+
+257
+00:18:44,300 --> 00:18:47,560
+occurs several years after measles يعني بيحدث بعد
+
+258
+00:18:47,560 --> 00:18:51,540
+قدت سنوات من مرض اللي هو الحصبة
+
+259
+00:18:52,730 --> 00:18:56,150
+missiles in pregnant women برضه بشكل خطورة كبيرة
+
+260
+00:18:56,150 --> 00:18:59,570
+جدا lead to an increased risk of still birth still
+
+261
+00:18:59,570 --> 00:19:03,770
+birth يعني يولد ميتا يعني بيكمل ال term لكن بيولد
+
+262
+00:19:03,770 --> 00:19:09,140
+ميتاrather than congenital abnormalities يعني هذه
+
+263
+00:19:09,140 --> 00:19:12,440
+الاحتمالية ان يولد ميتا اعلى من احتمالية انه يصير
+
+264
+00:19:12,440 --> 00:19:15,140
+عنده congenital abnormalities ال congenital
+
+265
+00:19:15,140 --> 00:19:19,300
+abnormalities ارتبطت بمين؟ ارتبطت بالربلة ارتبطت
+
+266
+00:19:19,300 --> 00:19:23,120
+بالربلة لذلك هم بيقولوا ان ال missiles is more
+
+267
+00:19:23,120 --> 00:19:28,080
+severe لش؟ ال missiles قتلت المولود او الجنين
+
+268
+00:19:28,080 --> 00:19:32,100
+بينما الربلة فقط عملت congenital abnormality
+
+269
+00:19:34,080 --> 00:19:38,100
+الـ laboratory diagnosis لالدزيز غالبا ال most
+
+270
+00:19:38,100 --> 00:19:42,640
+diagnosis جونا is based on clinical ground، إيش ال
+
+271
+00:19:42,640 --> 00:19:47,500
+clinical ground؟ ال complex spot؟ و إيش كمان؟
+
+272
+00:19:47,500 --> 00:19:51,360
+الرعش اللي جونا عنه بيبدأ في الوجه و بينتشر إلى
+
+273
+00:19:51,360 --> 00:19:54,820
+باقي أجزاء الدسم و بيكون موجود على وحتي اليد و
+
+274
+00:19:54,820 --> 00:20:03,940
+القدمةلكن أيضا يمكن القياس الـ antibody tighter
+
+275
+00:20:03,940 --> 00:20:09,040
+ويعرفين ال four fold increase من ال acute إلى ال
+
+276
+00:20:09,040 --> 00:20:17,300
+convalescent period لسوء حظنا ان مافي لنا اي
+
+277
+00:20:17,300 --> 00:20:22,020
+antiviral therapy لهذا ال diseaseلكن لحُصن الحظ إن
+
+278
+00:20:22,020 --> 00:20:25,940
+في عندنا إمكانية إنه نعمل prevention لهذا ال
+
+279
+00:20:25,940 --> 00:20:30,660
+disease وهو من خلال ال vaccination اتطلعولي على
+
+280
+00:20:30,660 --> 00:20:37,340
+الفترة الزمنيةاللي بنعطيها الفاكسين أول مرة،
+
+281
+00:20:37,340 --> 00:20:42,180
+بنعطيها على عمر جداش خمستاشر شهر من العمر ويمكن
+
+282
+00:20:42,180 --> 00:20:45,580
+احنا نقشنا هذا الموضوع صادقا وقلنالكم يا بنات
+
+283
+00:20:45,580 --> 00:20:50,840
+طالما انتوا انتوا الان مطعمين يبقى الموليد الناتج
+
+284
+00:20:50,840 --> 00:20:54,860
+عنكم ايضا هيكون فيها انتقل الها antibodies منكم
+
+285
+00:20:54,860 --> 00:20:59,210
+اليهملو أعطيناهم فكسين في ال day one و day two و
+
+286
+00:20:59,210 --> 00:21:02,430
+month one و month two، غالبا بالظبط ال antibody
+
+287
+00:21:02,430 --> 00:21:05,810
+اللي هي maternal بسميها antibody will neutralize
+
+288
+00:21:05,810 --> 00:21:09,650
+اللي هو الفيروس وبتالي ال immunization نفسها هتكون
+
+289
+00:21:09,650 --> 00:21:11,050
+كفائتها أقل
+
+290
+00:21:13,650 --> 00:21:17,890
+الان ال vaccine لا يُعطى لوحده وانما يُعطى ضمن
+
+291
+00:21:17,890 --> 00:21:24,110
+صفقة اسمها MMR اللي هم ال missiles, mumps و الربلط
+
+292
+00:21:24,110 --> 00:21:28,370
+طبعا التلاتة بيشتركوا ببعض الصفات وبالتالي يعني
+
+293
+00:21:28,370 --> 00:21:31,670
+لهم one single zero types وعطيناهم مع بعض وكانت
+
+294
+00:21:31,670 --> 00:21:37,930
+كفائتهم مع بعض جيد فاكرين مرة في ال adenovirus
+
+295
+00:21:37,930 --> 00:21:43,460
+عطينا لل .. لل military recruitsعطيناهم vaccine
+
+296
+00:21:43,460 --> 00:21:47,640
+لكن عطيناهم vaccine وحادي وحادي وحادي بمعنى آخر
+
+297
+00:21:47,640 --> 00:21:52,620
+هما تلاتة على تلت فترات متباعدة واش كان السبب؟ ان
+
+298
+00:21:52,620 --> 00:21:55,460
+واحد بيعمل interference مع التاني، تبقى مش
+
+299
+00:21:55,460 --> 00:21:57,960
+هتعطيناهم مع بعض ومبسوطين انهم قاطينهم مع بعض ..
+
+300
+00:21:57,960 --> 00:22:03,420
+مع بعض واضح انهم بيستهدفوا .. واضح انهم بيستهدفوا
+
+301
+00:22:03,420 --> 00:22:08,320
+أنسجة او خلايا مختلفة وبالتالي ماحدش بتعرض مع مين؟
+
+302
+00:22:08,320 --> 00:22:09,100
+مع التاني
+
+303
+00:22:13,830 --> 00:22:16,770
+طبعا احنا نوضح دالش بنعطي vaccination على خمساشر
+
+304
+00:22:16,770 --> 00:22:22,550
+شهر لكن بيكونوا تعرفوا ان ال vaccine لا يعطي مناعة
+
+305
+00:22:22,550 --> 00:22:28,750
+مثل ال natural infection وبالتالي immunity و ال
+
+306
+00:22:28,750 --> 00:22:35,750
+when و كلمة when يعني سوف تذوييعني تنحدر تدريجيا
+
+307
+00:22:35,750 --> 00:22:39,470
+لذلك poster dose وكلمة poster عرفناها برضه
+
+308
+00:22:39,470 --> 00:22:42,470
+واتكلمنا فيها قبل هيك poster هي الجرعة المنشطة أو
+
+309
+00:22:42,470 --> 00:22:47,810
+الجرعة المسمية دائمة لجهاز المناعم ال vaccine
+
+310
+00:22:47,810 --> 00:22:50,310
+should not be given to immunocompromised or
+
+311
+00:22:50,310 --> 00:22:54,490
+pregnant women معلومة
+
+312
+00:22:54,490 --> 00:22:58,030
+مهمة جدا كلمة immunocompromised ده جماعة احنا برضه
+
+313
+00:22:58,030 --> 00:23:03,320
+مرارا وتكرارا قلنالكم لا يمكن قياسها لكنالطفل
+
+314
+00:23:03,320 --> 00:23:09,260
+المريض هو immunocompromisedيعني ما نروحش نطعم طفل
+
+315
+00:23:09,260 --> 00:23:13,760
+و عنده حمّة لإن الجهاز المناعه تبعه الآن هو ضعيف و
+
+316
+00:23:13,760 --> 00:23:17,860
+مشغول ب disease فإذا عطنا هذا life attenuated
+
+317
+00:23:17,860 --> 00:23:24,440
+vaccine قد يحدث لديه العراب بشكل يعني كأنه مريض
+
+318
+00:23:24,440 --> 00:23:27,880
+missiles و هذا ممكن يؤثر عليه و ي meetه أيضا
+
+319
+00:23:27,880 --> 00:23:31,900
+فبالتالي ما لازم يكون المفهوم لدينا أن كلمة طفل
+
+320
+00:23:31,900 --> 00:23:34,640
+مريض لا يتعرض لvaccination
+
+321
+00:23:37,600 --> 00:23:42,260
+الـ Vaccine أدى إلى خفض عدد حالات الـ Measles في
+
+322
+00:23:42,260 --> 00:23:48,000
+الولايات المتحدة بشكل دراماتيكي في سنة 1997 تم
+
+323
+00:23:48,000 --> 00:23:56,060
+تسجيل في كل الولايات المتحدة فقط 138 حالة Measles
+
+324
+00:23:56,060 --> 00:24:00,460
+هذا رقم يعني ليس كان في الدول 138 حالة بالنسبة
+
+325
+00:24:00,460 --> 00:24:04,230
+للملايين اللي كانت موجودة فيه السنةhowever
+
+326
+00:24:04,230 --> 00:24:06,750
+وينالكوا outbreaks can still occur among
+
+327
+00:24:06,750 --> 00:24:16,310
+unimmunized individuals يعني في المدن
+
+328
+00:24:16,310 --> 00:24:19,730
+اللي داخل المدن زي ما وينالكوا ناس محوطين حالهم أو
+
+329
+00:24:19,730 --> 00:24:26,030
+منعزلين عن المدينة بصفات معينة بعداد معينة
+
+330
+00:24:26,030 --> 00:24:30,440
+وبيمتنعوا عن الحصول على اللي هو ال vaccinationالـ
+
+331
+00:24:30,440 --> 00:24:32,520
+killed vaccine should not be used وقلنا لكوا
+
+332
+00:24:32,520 --> 00:24:39,380
+ماتعطيش مناعة جيدة للمرض، هناك أيضا تحضيرات اسمها
+
+333
+00:24:39,380 --> 00:24:44,380
+immunoglobulin لالميسلز can be used to modify the
+
+334
+00:24:44,380 --> 00:24:47,920
+disease، إيش يعني modify the disease؟ يعني نعدل
+
+335
+00:24:47,920 --> 00:24:51,140
+المسار تبع المرض، المسار تبع المرض خطير، إحنا بدنا
+
+336
+00:24:51,140 --> 00:24:56,240
+نعدله إلى إنه يكون أقل خطورة من خلال استخدامنا لل
+
+337
+00:24:56,240 --> 00:25:01,260
+immunoglobulinمتى .. متى بنلجأ إلها؟ بنعطيها لـ
+
+338
+00:25:01,260 --> 00:25:05,120
+Unimmunized Individuals يعني أشخاص ماتوا .. ماتوا
+
+339
+00:25:05,120 --> 00:25:09,360
+طعموا لأسباب معينة، فترة الولادة، سافروا من مكان
+
+340
+00:25:09,360 --> 00:25:12,920
+إلى مكان، المكان .. لا .. لا طعموا في المكان اللي
+
+341
+00:25:12,920 --> 00:25:16,040
+هم كانوا فيه ولا للمكان اللي انتقلوا منه، ضمن منهم
+
+342
+00:25:16,040 --> 00:25:19,100
+انهم حصلوا على هذا التطييم على سبيل المثال، هذا
+
+343
+00:25:19,100 --> 00:25:24,840
+أحد الأمثلة اللي بنشوفها أو اللي بيغطيهاش بعض
+
+344
+00:25:24,840 --> 00:25:30,320
+الأحيان ال vaccineThis is especially necessary if
+
+345
+00:25:30,320 --> 00:25:34,360
+the unimmunized individuals are immunocompromised
+
+346
+00:25:34,360 --> 00:25:38,260
+خاصة إذا كانوا بالفعل الأشخاص دول اللي مش
+
+347
+00:25:38,260 --> 00:25:41,480
+immunized و في نفس الوقت مالهم immunocompromised،
+
+348
+00:25:41,480 --> 00:25:44,640
+احنا ماعطيهمش vaccine، اذا ماعطيهم immunoglobulin
+
+349
+00:25:44,640 --> 00:25:52,300
+الفيروس التاني اللي عمل يعني ضجة عالمية قبل عامين
+
+350
+00:25:52,300 --> 00:25:55,660
+في فلسطين هو ال mum's virus
+
+351
+00:25:58,760 --> 00:26:04,620
+و مدام يعني كمقدمة خلّيني أتكلم عن ما حدث و نربطه
+
+352
+00:26:04,620 --> 00:26:09,760
+ببعض المعلومات اللي كانت لدينا موجودة السابق كان
+
+353
+00:26:09,760 --> 00:26:13,140
+فينا طالبة مجلستها رحنا أشرف عليها الأستاذ الدكتور
+
+354
+00:26:13,140 --> 00:26:17,460
+محمد عيد الشبير و أنا ساعدته في هذه الرسالة للكشف
+
+355
+00:26:17,460 --> 00:26:24,080
+عن مدى نجاعت التطعيم لمجموعة من الأمراض الفيروسية
+
+356
+00:26:24,080 --> 00:26:29,180
+منهاالـ MMR و بكتيريا اللي هي الـ
+
+357
+00:26:29,180 --> 00:26:31,740
+Bordetelapartosis هدولة كانت الأربع اللي هو ال
+
+358
+00:26:31,740 --> 00:26:34,700
+target اللي لنا فكانت ناخد عينات من أطفال من أعمار
+
+359
+00:26:34,700 --> 00:26:40,900
+مختلفة و نجيس مستوى ال antibody لل .. للفيروسات
+
+360
+00:26:40,900 --> 00:26:46,270
+التلاتة و ال .. و ال .. و البكتيرياهو طبعا في
+
+361
+00:26:46,270 --> 00:26:50,190
+المحصرة النهائية اقوله مثلا انا لقد كل الأرقام
+
+362
+00:26:50,190 --> 00:26:55,430
+الصحيح 200 طفل 300 طفل النسب اللي طلعت معانا بتقول
+
+363
+00:26:55,430 --> 00:27:01,530
+ان الكفاءة تبعت ال vaccine بعضهم وصلت ل 90% وفي
+
+364
+00:27:01,530 --> 00:27:06,530
+منهم فقط ل 70% ال moms كان واحد من ال ايه من
+
+365
+00:27:06,530 --> 00:27:11,310
+المنخفضينفكنا لسه من الدعوة لإنه ليش الكفاءة تبع
+
+366
+00:27:11,310 --> 00:27:16,410
+هذا الفيروس أو عفوًا الفاكسين ضعيفة في قطاع غزة طب
+
+367
+00:27:16,410 --> 00:27:19,470
+هذا ممكن يشك الخطر و هذا بالعامل اللي بعديه ليه
+
+368
+00:27:19,470 --> 00:27:24,230
+مباشرة إذا بيحدث عنا اللي هو الأوجهة النقطة اللي
+
+369
+00:27:24,230 --> 00:27:28,470
+بدكرها هذي بدكرها عشان أقولكوا أنه أي vaccination
+
+370
+00:27:28,470 --> 00:27:32,370
+programلازم يصيرله evaluation، ايش يعني
+
+371
+00:27:32,370 --> 00:27:37,350
+evaluation؟ تقيين، بنفحص طاعة من الناس ووركن انه
+
+372
+00:27:37,350 --> 00:27:42,390
+خلاص هذا ال vaccine فعال تمام، في أمريكا حاجة
+
+373
+00:27:42,390 --> 00:27:48,350
+اسمها cold transport chain، ايش ال cold transport
+
+374
+00:27:48,350 --> 00:27:54,750
+chain؟اللي هي نقل ال vaccine من مصنعه إلى مخزنه،
+
+375
+00:27:54,750 --> 00:27:58,710
+طبعا مصنعه مش هان، مصنعه في دول بعيدة جدا، و احنا
+
+376
+00:27:58,710 --> 00:28:01,070
+للأسف يعني اللي بيجينا بينتقل إنا و بيروح على
+
+377
+00:28:01,070 --> 00:28:04,150
+حواجز، بنزل في مين أسدود، و بقول له كام من يوم، و
+
+378
+00:28:04,150 --> 00:28:07,270
+بيجي على حاجز إيرز، و بقول له كام من يوم، و بعدين
+
+379
+00:28:07,270 --> 00:28:10,470
+اللي بيقولوا عنه هنا، فبالتالي قد يتأثر، خاصة
+
+380
+00:28:10,470 --> 00:28:13,910
+المسكلة مع المين احنا، عن live attenuated vaccine
+
+381
+00:28:14,500 --> 00:28:16,600
+هذا جانب من الجوانب اللي احنا لازم نعملها
+
+382
+00:28:16,600 --> 00:28:21,300
+evaluation لذلك خدوا بالكم مش المفروض نستلم الشحنة
+
+383
+00:28:21,300 --> 00:28:26,620
+اللي ده كان معنا سجل يسجل تاريخ الرحلة من أول ما
+
+384
+00:28:26,620 --> 00:28:32,590
+طلعت إلى أخر ما وصلتني تاريخ سجل التلاجاتبكون فيه
+
+385
+00:28:32,590 --> 00:28:37,390
+chart او اليوم برامج حسوب بتعطينا سجل كل دقيقة
+
+386
+00:28:37,390 --> 00:28:41,130
+بتسجل درجة الحرارة في هذا المكان اذا فشلوا انه في
+
+387
+00:28:41,130 --> 00:28:44,750
+نص ساعة يعطوني واجت نص ساعة فهذه الشحنة غير مقبوضة
+
+388
+00:28:44,750 --> 00:28:50,960
+لدينا على سبيل المثال الجانب التانيالان انا قاعد
+
+389
+00:28:50,960 --> 00:28:55,080
+باعطي جرعة .. جرعة ل .. حتى لو اضمنت ان ال .. ان
+
+390
+00:28:55,080 --> 00:28:58,400
+ال .. ان ال cold transport chain كانت فعالة ممتازة
+
+391
+00:28:58,400 --> 00:29:02,180
+و التخزين كان جيد، هل هناك ضمانة انه ال vaccine
+
+392
+00:29:02,180 --> 00:29:06,300
+نفسه يكون effective؟ مافيش ضمانة، هو بالتالي الاصل
+
+393
+00:29:06,300 --> 00:29:10,640
+انه نفس الجهة المسؤولة عن ال vaccinationتقوم
+
+394
+00:29:10,640 --> 00:29:16,260
+بدراسات لمعرفة مدى نجاعة هذه ال vaccine وإلا في
+
+395
+00:29:16,260 --> 00:29:18,820
+يوم من الأيام حصلنا واباق ونقول طب يا عم احنا كنا
+
+396
+00:29:18,820 --> 00:29:22,360
+عاملين وخسرانين يعني ملايين الدولارات على ال
+
+397
+00:29:22,360 --> 00:29:25,520
+vaccination ال vaccination expensive وخاصة بتغطي
+
+398
+00:29:25,520 --> 00:29:29,460
+كلالسكانة بتاعي هي تكلفة عالية وبتاعي لازم تكون
+
+399
+00:29:29,460 --> 00:29:33,580
+بالفعل دهت كفاءة وما نتفاجأ فجأة انه سينا واباق زي
+
+400
+00:29:33,580 --> 00:29:36,760
+مثلا واباق اللي هو ال moms اللي احنا كنا اعتقدنا
+
+401
+00:29:36,760 --> 00:29:40,940
+في السابق انه خلاص يعني خلصنا منه في السابق كذلك
+
+402
+00:29:40,940 --> 00:29:44,440
+الأمر بالنسبة لل border tell apertosis لم نجد يعني
+
+403
+00:29:44,440 --> 00:29:49,580
+نسب عالية من الكفاءة لل vaccine وبتاعي بنقول انه
+
+404
+00:29:49,580 --> 00:29:56,080
+لابد من يعني التركيز علىدراسات أو البرامج اللي
+
+405
+00:29:56,080 --> 00:30:01,120
+بتضمن انه ال ال vaccinations يصير لها evaluation
+
+406
+00:30:01,120 --> 00:30:05,660
+بشكل مستمر حتى لو نفاجأ بهذا الشكل طيب هذا اللي
+
+407
+00:30:05,660 --> 00:30:09,120
+خلانا نتكلم عنه مين ال mumps و الوباء اللي صار في
+
+408
+00:30:09,120 --> 00:30:14,240
+ال mumps العام ال mumps disease this virus causes
+
+409
+00:30:14,240 --> 00:30:18,080
+mumps a disease characterized by a barotroid gland
+
+410
+00:30:18,080 --> 00:30:20,380
+swelling عارفين ال barotroid gland؟
+
+411
+00:30:23,250 --> 00:30:28,170
+It occurs primarily in childhood برضه مرض بيصيب
+
+412
+00:30:28,170 --> 00:30:31,710
+الطفولة او فيه حدث في الطفولة عفوا important
+
+413
+00:30:31,710 --> 00:30:36,570
+properties of the genome are RNA and nucleocapsid
+
+414
+00:30:36,570 --> 00:30:42,250
+are those of typical paramioxy virus يعني negative
+
+415
+00:30:42,250 --> 00:30:48,100
+senseSingle-stranded mRNA بيحتوي على RNA-dependent
+
+416
+00:30:48,100 --> 00:30:51,040
+RNA-polymerase وهيليكال نوكليوكابوسيد وإيش كمان
+
+417
+00:30:51,040 --> 00:30:54,600
+اللي هو envelope يعني هو الـtypical باراميوكسي
+
+418
+00:30:54,600 --> 00:30:59,360
+فيروس الهن نيجي لك نتكلم عن ال envelope spikes في
+
+419
+00:30:59,360 --> 00:31:03,020
+الممس في أنهين أجلوتينين و neuroaminidase
+
+420
+00:31:03,720 --> 00:31:07,080
+activities and the other with cell fusion and
+
+421
+00:31:07,080 --> 00:31:10,860
+hemolytic activity تخيلوا واحد بيحتوي على
+
+422
+00:31:10,860 --> 00:31:14,580
+neuroamidase وفي نفس الوقت ايش بيحتوي على ال .. ال
+
+423
+00:31:14,580 --> 00:31:17,480
+.. ال hemagglutinin طبعا في ال .. في ال orthopoxy
+
+424
+00:31:17,480 --> 00:31:22,640
+virus كان واحد neuroamidase واحد hemagglutinin هنا
+
+425
+00:31:22,640 --> 00:31:27,120
+اتنين على one single spike والتاني له cell fusion
+
+426
+00:31:27,120 --> 00:31:31,480
+and hemolytic activity إذا أنا مغطي مين؟ مغطيهم
+
+427
+00:31:31,480 --> 00:31:36,410
+كلهمهي مبقى glutenين نيرو أميديز زاد اللي هو cell
+
+428
+00:31:36,410 --> 00:31:43,290
+fusionالفيروين لديه اتجارات اتجارات اتجارات
+
+429
+00:31:43,290 --> 00:31:43,870
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+430
+00:31:43,870 --> 00:31:47,710
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+431
+00:31:47,710 --> 00:31:53,230
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+432
+00:31:53,230 --> 00:31:53,990
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+433
+00:31:53,990 --> 00:31:54,690
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+434
+00:31:54,690 --> 00:31:54,690
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+435
+00:31:54,690 --> 00:32:06,530
+اتجارات اتجارات اتجارات اتجارات ا
+
+436
+00:32:07,930 --> 00:32:11,770
+The internal nucleocapsid protein is the S وسموه
+
+437
+00:32:11,770 --> 00:32:14,910
+soluble antigen detecting in the complement
+
+438
+00:32:14,910 --> 00:32:17,750
+fixation test for the diagnosis.إذا هذا الجملة
+
+439
+00:32:17,750 --> 00:32:20,610
+بتقولنا أنه في معلوم تانية بتقولنا أنه ال
+
+440
+00:32:20,610 --> 00:32:23,650
+diagnosis بتتم من خلال complement fixation test
+
+441
+00:32:23,650 --> 00:32:27,590
+.بنكشف فيه عن مين؟ عن soluble antigen وين موجود في
+
+442
+00:32:27,590 --> 00:32:32,450
+ال nucleocapsin.Human are the natural أو the only
+
+443
+00:32:32,450 --> 00:32:39,510
+natural host for this virus.إذا بيقدر استنتج من
+
+444
+00:32:39,510 --> 00:32:44,390
+هذه اللوحة إنه في كتير شبه بين ال moms و بين اللي
+
+445
+00:32:44,390 --> 00:32:48,450
+هو ال para .. اعفوا ال missiles virus، إيش أوجد
+
+446
+00:32:48,450 --> 00:32:52,850
+الشبه كلاهما؟ Para myoxivirus كلاهما بيمتلك نفس
+
+447
+00:32:52,850 --> 00:32:58,690
+الخصائص لكن هناك بعض الاختلافاتالتشابهات ذكرناها و
+
+448
+00:32:58,690 --> 00:33:02,470
+ذكرنا انه هو single serotype و ال human are the
+
+449
+00:33:02,470 --> 00:33:05,970
+only natural host لكن الاختلاف في موضوع اللي هو ال
+
+450
+00:33:05,970 --> 00:33:10,250
+spikes انه ال spikes نيرواميندز و هي مقالوتنين on
+
+451
+00:33:10,250 --> 00:33:14,230
+one spike و على الطرف التاني فيه انه اللي هو ال
+
+452
+00:33:14,230 --> 00:33:18,450
+fusion protein ايضا
+
+453
+00:33:18,450 --> 00:33:21,190
+من اوجه الشبه انه بينتقلوا التنين عن اللي هو ال
+
+454
+00:33:21,190 --> 00:33:24,960
+respiratory droplets او respiratory tractمامس
+
+455
+00:33:24,960 --> 00:33:29,400
+أكارز أيضا worldwide، هذا برضه أي وجه شبه، with a
+
+456
+00:33:29,400 --> 00:33:33,800
+peak incidence in the winter فاكرين كلمة winter
+
+457
+00:33:33,800 --> 00:33:39,860
+نقشناها قبلك ولا ما نقشناها الشتاء؟لماذا يكون بعض
+
+458
+00:33:39,860 --> 00:33:43,840
+الأمراض مثل ال influenza في الشتاء زي واحدة كمان
+
+459
+00:33:43,840 --> 00:33:47,620
+نفس الشيء في الشتاء أكثر منه في الصيف؟ طبعا
+
+460
+00:33:47,620 --> 00:33:51,920
+الإجابة المنطقية اللي لديكم ان هو درجة من الحرارة
+
+461
+00:33:51,920 --> 00:33:59,180
+كيف لدرجة الحرارة أن تؤثر على انتقال الفيروس هذا
+
+462
+00:33:59,180 --> 00:34:03,280
+السؤال مش السؤال انه درجة الحرارة وخلاصاللي احنا
+
+463
+00:34:03,280 --> 00:34:07,360
+هنا في ال .. في ال .. في المساجد .. في المساجد على
+
+464
+00:34:07,360 --> 00:34:11,580
+سبيل المثال في فصل الشتاء بنلاقيش ولا شباك مفتوح
+
+465
+00:34:13,670 --> 00:34:18,010
+ومغلق، لو كان واحد مصاب، بكل سهولة بينشر، في الصيف
+
+466
+00:34:18,010 --> 00:34:20,890
+فيه تهوية، فبالتالي فيه تيار دائما بيلف لف،
+
+467
+00:34:20,890 --> 00:34:24,810
+فبالتالي فيه، خدنا نقول distribution أو dilution
+
+468
+00:34:24,810 --> 00:34:28,290
+للفيروس، فكمية الفيروس اللي بياخدها بتكون ايه؟ اقل
+
+469
+00:34:28,290 --> 00:34:31,690
+طبعا بقول هذا سلوك سيء، ان احنا نسكر الشبابيك بشكل
+
+470
+00:34:31,690 --> 00:34:36,630
+.. بشكل تام وخاصة في أماكن مغلقة مثل القاعات
+
+471
+00:34:36,630 --> 00:34:41,030
+الصفية هذه او ال .. ال .. المساجد او اي قاعات
+
+472
+00:34:41,030 --> 00:34:46,710
+اجتماعات اخرىهذا احد العوامل الناس يميلوا الى
+
+473
+00:34:46,710 --> 00:34:51,490
+الابتراب من بعضهم في بصل الشتاء مابهتموش لأنهم
+
+474
+00:34:51,490 --> 00:34:54,170
+يكونوا بعيد عن بعض ففيه بيكون close contact دي
+
+475
+00:34:54,170 --> 00:34:58,890
+كمان عامل تالت اللي هو ال survival تبع الفيروس في
+
+476
+00:34:58,890 --> 00:35:03,330
+ال environment هذا enveloped صح؟ وانت عارفين انه
+
+477
+00:35:03,330 --> 00:35:06,870
+ال envelope virus ال survival تبعه هيكون ضعيف ال
+
+478
+00:35:06,870 --> 00:35:10,410
+low temperature ال survival rate تبعتها بيكون اعلى
+
+479
+00:35:10,620 --> 00:35:14,280
+يبقى بقاءها في ال environment في فصل الشتاء بيكون
+
+480
+00:35:14,280 --> 00:35:18,060
+أفضل من بقاءها في من يفصل اللي هو الصيف فبعطيها
+
+481
+00:35:18,060 --> 00:35:22,260
+فرصة أكبر في الانتقال من إنسان إلى إنسان آخر
+
+482
+00:35:22,260 --> 00:35:28,580
+تقريبا تلاتين بالمية من الأطفال اللي بيصابوا بيكون
+
+483
+00:35:28,580 --> 00:35:31,780
+عندهم subclinical وكلمة subclinical يعني لا يظهر
+
+484
+00:35:31,780 --> 00:35:37,390
+عليهم أي أعرض هكذا بنعرف أنهم أصيبوامن خلال فقط
+
+485
+00:35:37,390 --> 00:35:40,610
+فحص antibody يعني surveillance .. surveillance
+
+486
+00:35:40,610 --> 00:35:48,890
+survey there were only 683 reported cases of mumps
+
+487
+00:35:48,890 --> 00:35:53,010
+in the United States in 1997 برضه الرقم في
+
+488
+00:35:53,010 --> 00:36:00,150
+الولايات المتحدة 683 في ال 1997 هذا رقم دقيق جدا
+
+489
+00:36:00,150 --> 00:36:06,100
+على بالكان خنيونيس طلعت أكتر منهم في تلك الفترة
+
+490
+00:36:06,100 --> 00:36:09,800
+أهل خنيونيس أعطوه الذهب له .. هو .. هو .. هو بدأ
+
+491
+00:36:09,800 --> 00:36:13,180
+في خنيونيس بس انتقل على كل اللي هو القطاع تقريبا و
+
+492
+00:36:13,180 --> 00:36:19,120
+أكتر يعني ناس أصيبهم فيه من أطفال المدارس القصد من
+
+493
+00:36:19,120 --> 00:36:23,860
+الكلام أن ال vaccination الفعال كان له تأثير كبير
+
+494
+00:36:23,860 --> 00:36:27,840
+في خفض عدد اللي هو الإصابات بهذا الفيروس
+
+495
+00:36:30,370 --> 00:36:36,170
+كيف يحدث هذا الفيروس المرض وما دور المناعة فيه الـ
+
+496
+00:36:36,170 --> 00:36:38,930
+virus infects the upper respiratory tract and then
+
+497
+00:36:38,930 --> 00:36:44,250
+spread through the blood and to infect the parotid
+
+498
+00:36:44,250 --> 00:36:48,810
+gland, testes, ovaries and pancreas شوفوا الأعضاء
+
+499
+00:36:48,810 --> 00:36:52,610
+اللي بتصاب بهذا الفيروس الـ parotid gland طبعا هي
+
+500
+00:36:52,610 --> 00:36:56,210
+اللي بنشوفها بسرعة بينما في ال .. في ال male في
+
+501
+00:36:56,210 --> 00:36:59,830
+الذكور الأطفال الذكورهتصل الى ال testes و في
+
+502
+00:36:59,830 --> 00:37:04,010
+الإناث بتروح على بين على ال ovaries و ك common
+
+503
+00:37:04,010 --> 00:37:06,970
+part اللى هو البنك الياسى and in some cases ممكن
+
+504
+00:37:06,970 --> 00:37:13,450
+تتصل الى ال meninges Alternatively ممكن في plan B
+
+505
+00:37:13,450 --> 00:37:17,250
+للفيروس ال virus may ascend from the buccal mucosa
+
+506
+00:37:17,250 --> 00:37:21,490
+up to Stinson duct to the parotoid gland يعني بدل
+
+507
+00:37:21,490 --> 00:37:27,030
+مايروح على الدم من نفس الفم بيصل الى ال parotoid
+
+508
+00:37:27,030 --> 00:37:32,960
+glandlifelong immunity occurs in a person who have
+
+509
+00:37:32,960 --> 00:37:36,820
+had the disease، برضه نفس الفكرة لمين؟ للميسلز،
+
+510
+00:37:36,820 --> 00:37:41,190
+كنا بيعطينا long life immunitymumps occurs only
+
+511
+00:37:41,190 --> 00:37:47,110
+once و سواء كان أصاب الجهتين أو أصاب جهة واحدة إذا
+
+512
+00:37:47,110 --> 00:37:51,090
+أصاب جهة واحدة تمام لن يحدث مرة أخرى في الجهة
+
+513
+00:37:51,090 --> 00:37:55,050
+التانية كما كانوا معتقد عن كثير من الناس إذا هي
+
+514
+00:37:55,050 --> 00:38:00,070
+أصابة لمرة واحدة سواء كان في طرف أو في طرفين أو لم
+
+515
+00:38:00,070 --> 00:38:03,730
+يظهر عليه أعراض لن يصاب مرة أخرى
+
+516
+00:38:06,090 --> 00:38:09,350
+Maternal antibody passes the placenta and provide
+
+517
+00:38:09,350 --> 00:38:12,550
+protection during the first six months of life،
+
+518
+00:38:12,550 --> 00:38:16,250
+إذا بيوفروا حماية لمدة تقريبا إيه؟ ست شهور، لحظة
+
+519
+00:38:16,250 --> 00:38:19,490
+أن ال vaccine يا جماعة بنعطيها لمين احنا؟ على
+
+520
+00:38:19,490 --> 00:38:25,110
+خمستاشر شهر، لإن ال MMR هو أصلا موجود في ال moms
+
+521
+00:38:27,330 --> 00:38:32,290
+طبعا هذه صورة لطفل بيورينا انه المنطقة اللي خدت
+
+522
+00:38:32,290 --> 00:38:36,430
+بتكون متورمة وقد يكون بيقولنا unilateral او
+
+523
+00:38:36,430 --> 00:38:40,930
+bilateral للأسف كان فينا يعني عادات سيئة للغاية
+
+524
+00:38:40,930 --> 00:38:47,070
+ومعتقدات ناتج عن الجهل الكبير في الأطفال المصابين
+
+525
+00:38:47,070 --> 00:38:54,540
+كان يكتب لهم آيات قرآنيةيعني هو القرآن نعم يستشفى
+
+526
+00:38:54,540 --> 00:39:00,180
+بيه لكن لا يُكتب وإنما يُقرأ على المريض After an
+
+527
+00:39:00,180 --> 00:39:04,760
+incubation period of 18 to 21 days، إذا أطول شوية
+
+528
+00:39:04,760 --> 00:39:09,380
+من مين؟ من النيسل A prodromal stage، وكلكم بتعرفوا
+
+529
+00:39:09,380 --> 00:39:12,340
+الآن prodromal اللي هو الـ non-specific symptoms
+
+530
+00:39:12,340 --> 00:39:15,920
+of fever, malaise and anorexia is followed by
+
+531
+00:39:15,920 --> 00:39:19,490
+tender swellingof the parotid gland tender
+
+532
+00:39:19,490 --> 00:39:23,550
+swelling يعني انتفاخ مؤلم either unilateral or
+
+533
+00:39:23,550 --> 00:39:29,870
+bilateral من الأشياء اللي بتخلي الأطباء يعرفوا انه
+
+534
+00:39:29,870 --> 00:39:36,490
+الألم بيزيد when drinking citrus juices لما بياخد
+
+535
+00:39:36,490 --> 00:39:40,490
+عصائر زي برتقال او grapefruit او كليمنتين او اي من
+
+536
+00:39:40,490 --> 00:39:48,110
+المشروبات اللي هي الحمضيات بيزيد اللي هو الألمالـ
+
+537
+00:39:48,110 --> 00:39:50,990
+disease is typically .. typically benign يعني
+
+538
+00:39:50,990 --> 00:39:57,630
+غالبا مابي .. يعني مابيقتلش ال .. ال .. ال ..
+
+539
+00:39:57,630 --> 00:40:00,730
+المريض لكن في بعض الحالات احنا بيقولنا بيصل ال
+
+540
+00:40:00,730 --> 00:40:04,370
+testis مظبوط و بيصل ال .. ال ovary و فممكن يعمل
+
+541
+00:40:04,370 --> 00:40:08,670
+infertility خاصة عند الذكورBenign and resolve
+
+542
+00:40:08,670 --> 00:40:11,430
+spontaneously within one week. Two complications
+
+543
+00:40:11,430 --> 00:40:14,630
+are significant. One is orchitis اللي هي التهيأب
+
+544
+00:40:14,630 --> 00:40:19,110
+الخصية زي ما قلنا in post-perpetual male اللي هم
+
+545
+00:40:19,110 --> 00:40:24,450
+في فرحة البلوغ which if bilateral can result in
+
+546
+00:40:24,450 --> 00:40:28,250
+sterility إذا كان في الخصيتين غالبا بيقدي إلى اللي
+
+547
+00:40:28,250 --> 00:40:31,490
+هو العقوم عند هؤلاء البالغين الجدد
+
+548
+00:40:34,100 --> 00:40:37,820
+الـ Unilateral Orchitis although quite painful
+
+549
+00:40:37,820 --> 00:40:41,700
+does not lead to sterility لأن الجهة التانية ما
+
+550
+00:40:41,700 --> 00:40:46,480
+زالت تعمل وبتالي يعني مايكونش فيه فقدان تاملة اللي
+
+551
+00:40:46,480 --> 00:40:50,840
+هو الحيوانات المنوية The other complication is
+
+552
+00:40:50,840 --> 00:40:54,160
+meningitis إذا فينا Orchitis وفينا meningitis ال
+
+553
+00:40:54,160 --> 00:40:58,460
+Orchitis كسب منها جسمين Unilateral و Bilateral ال
+
+554
+00:40:58,460 --> 00:41:01,540
+Bilateral الجون عنها بتسبب Sterility أما ال
+
+555
+00:41:01,540 --> 00:41:06,190
+Unilateral غالبا بتسببشالكمبليكشن التانية اللي هي
+
+556
+00:41:06,190 --> 00:41:09,710
+الـ meningitis which is usually benign, self
+
+557
+00:41:09,710 --> 00:41:14,670
+-limited and without sequel غالبا بتأديش إلى حتى
+
+558
+00:41:14,670 --> 00:41:17,070
+يعني بعض المضاعفات اللي بنشوفها في البكتيرا الـ
+
+559
+00:41:17,070 --> 00:41:19,970
+meningitis، بنشوفهاش في هذا النوع من الـ
+
+560
+00:41:19,970 --> 00:41:24,030
+meningitis طبعا الـ mumps بالإضافة إلى الكوكساكي
+
+561
+00:41:24,030 --> 00:41:28,050
+فيروس والإيكو فيروس are the three most frequent
+
+562
+00:41:28,050 --> 00:41:33,190
+causes of viral وبين جثين aseptic meningitisإيش
+
+563
+00:41:33,190 --> 00:41:37,190
+يعني أسبتك حكيناها قبلهاك، إن العائل أو الكائن
+
+564
+00:41:37,190 --> 00:41:40,710
+المسبب لـmenenditis غير قابل للعزل بالطرق
+
+565
+00:41:40,710 --> 00:41:44,570
+التقليدية اللي تنهولها في المختبر؟The widespread
+
+566
+00:41:44,570 --> 00:41:48,430
+of the vaccine in the United States had led to a
+
+567
+00:41:48,430 --> 00:41:51,170
+marked decrease in the incidence of mumps in
+
+568
+00:41:51,170 --> 00:41:54,190
+meningitis. طب و أحنا عملنا أصلا marked decrease
+
+569
+00:41:54,190 --> 00:41:57,770
+في ال mumps نفسه، صح؟ وبالتالي أكيد هيكون فيه
+
+570
+00:41:57,770 --> 00:42:01,390
+marked increase إذا كان كل الحالات لم يتجاوزوا ال
+
+571
+00:42:01,390 --> 00:42:06,610
+800، صح؟ أو 700، لم يتجاوزوا ال 700 في عام 1997،
+
+572
+00:42:06,610 --> 00:42:11,290
+وبالتالي أكيد ال meningitis هتكون أقل بقليل من ذلك
+
+573
+00:42:12,720 --> 00:42:17,860
+خلبي كتير عفوا ال laboratory diagnosis غالبا اقول
+
+574
+00:42:17,860 --> 00:42:23,380
+لكوا clinicallyطبعا يولاترال او بيلاترال but
+
+575
+00:42:23,380 --> 00:42:26,000
+laboratory tests are available for confirmation
+
+576
+00:42:26,000 --> 00:42:29,560
+انا للأسف يعني يحزني دائما انه دائما اذكر هذا
+
+577
+00:42:29,560 --> 00:42:33,760
+الحقيقة انه ليس لدينا حتى ال influenza ال
+
+578
+00:42:33,760 --> 00:42:36,080
+influenza اللي شفنا جداش مجموعة الفحوصات اللي لها
+
+579
+00:42:36,080 --> 00:42:39,620
+غير متوفر لها فحوصات ال missiles غير متوفر لها
+
+580
+00:42:39,620 --> 00:42:44,080
+فحوصات ال moms غير متوفر لها فحوصات فقط clinical و
+
+581
+00:42:44,080 --> 00:42:47,350
+ال clinical يا جماعة ممكن بعض الأحيانتتشابه كثير
+
+582
+00:42:47,350 --> 00:42:51,410
+من الأعراض أو لا تظهر الأعراض كاملة full يعني
+
+583
+00:42:51,410 --> 00:42:55,710
+وبتالي بيصير فينا misdiagnosis لبعض الحالات هذا ال
+
+584
+00:42:55,710 --> 00:43:00,070
+misdiagnosis لما انا اقول لمريد عنده مامس روح روح
+
+585
+00:43:00,070 --> 00:43:04,330
+عده وماعنكاش حاجة هذا التهاب بكتيري او كده مش هذا
+
+586
+00:43:04,330 --> 00:43:08,410
+هيكون مصدر عدو للاخرين لكن لو كان شخصناه صح في
+
+587
+00:43:08,410 --> 00:43:11,890
+الغالب هنعزله عن الآخرين وناخد الاحتياطات اللازمة
+
+588
+00:43:11,890 --> 00:43:19,040
+لذلكالفيروس يمكن أن يكون مقفل في المثلجة من صليبا
+
+589
+00:43:19,040 --> 00:43:24,500
+أو مخلوق روحاني أو روحاني كمان ممكن نكشف قبل قليل
+
+590
+00:43:24,500 --> 00:43:27,600
+في أول لوحة أنه في عندنا سوليوب و الانتجين نكشف
+
+591
+00:43:27,600 --> 00:43:34,060
+عنه بإي اللي هو complement fixation test ممكن كمان
+
+592
+00:43:34,060 --> 00:43:39,430
+في skin testعارفين ال skin test انه نحقن المريض
+
+593
+00:43:39,430 --> 00:43:42,930
+intradermaly و بنشوف إذا كان فيه انه صار reaction
+
+594
+00:43:42,930 --> 00:43:49,710
+بعد 24-48 ساعة ال mum skin is widely used to
+
+595
+00:43:49,710 --> 00:43:53,630
+determine whether patients cell mediated immunity
+
+596
+00:43:53,630 --> 00:43:57,410
+is competent الآن هذا الفحص بطل يستخدموه لإن مافيش
+
+597
+00:43:57,410 --> 00:44:02,230
+اننا mums يعني بكمية كبيرة لكن لازال الفحص موجود
+
+598
+00:44:02,230 --> 00:44:07,020
+يعني واحد عندنا بيه مرض كتيرما لهوش علاقة بالكلام
+
+599
+00:44:07,020 --> 00:44:11,000
+اللي بنحكيه الآن احنا، بنبقى مرض كتير، بناعرف أنه
+
+600
+00:44:11,000 --> 00:44:14,780
+هل لأنه cell-mediated immunity deficiency، بنعمله
+
+601
+00:44:14,780 --> 00:44:19,520
+moms test، moms test، مش هو مطعم، لازم يطلع عيش
+
+602
+00:44:19,520 --> 00:44:22,940
+المفروض positive، صح؟ إذا بيطلع .. إذا .. إذا
+
+603
+00:44:22,940 --> 00:44:25,700
+بيطلع positive، بيكون المنعته منيحة، إذا بيطلع
+
+604
+00:44:25,700 --> 00:44:28,660
+negative، معناه الحاجة إنه ماعنوش أصلا هو منعه،
+
+605
+00:44:28,660 --> 00:44:33,680
+تمام؟وكانوا استخداموه ككاشف عن الـ cell mediated
+
+606
+00:44:33,680 --> 00:44:36,540
+image والمرة الجاية ان شاء الله بنكمل الأجزاء
+
+607
+00:44:36,540 --> 00:44:36,980
+الباقية
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Z755sWEZDxg.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Z755sWEZDxg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6644af6bd5afce9758aae5b4c8865c1032a577f4
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/Z755sWEZDxg.srt
@@ -0,0 +1,2203 @@
+1
+00:00:20,920 --> 00:00:25,480
+بسم الله الرحمن الرحيم اليوم هنتطرق لموضوع جديد
+
+2
+00:00:25,480 --> 00:00:29,100
+اللي هو الـ viral laboratory diagnosis وأنا بعتبره
+
+3
+00:00:29,100 --> 00:00:32,640
+من الفصول أيضًا المهمة جدًا لأنه بعرفنا على الطرق
+
+4
+00:00:32,640 --> 00:00:39,600
+المخبرية المتبعة في تشخيص الفيروسات، وكمقدمة لابد 
+
+5
+00:00:39,600 --> 00:00:47,360
+أن نعرف أن هناك خمس منهج، خمس طرق، خمس سبل للتعرف على
+
+6
+00:00:47,360 --> 00:00:51,800
+الـ .. أو تشخيص الفيروسات، رقم واحد: التعرف على
+
+7
+00:00:51,800 --> 00:00:56,140
+الفيروس في الـ cell culture، وهذا بدنا نشرحه شوية عن
+
+8
+00:00:56,140 --> 00:01:00,980
+الـ cell culture إن شاء الله. رقم اثنين: Microscopic
+
+9
+00:01:00,980 --> 00:01:04,200
+Examination، طبعًا أنتم ممكن فاكرين في المحاضرات
+
+10
+00:01:04,200 --> 00:01:07,080
+السابقة كنا نتكلم عن الـ cytopathic effect، الـ CPE
+
+11
+00:01:07,080 --> 00:01:10,300
+فالـ CPE إيه له علاقة بمين؟ بموضوع اللي هو الـ cell
+
+12
+00:01:10,300 --> 00:01:13,890
+culture، والـ Microscopic Examination برضه اتكلمنا 
+
+13
+00:01:13,890 --> 00:01:17,550
+عن حسمة ZnacSmear لما قلنا إنه بناخد من .. على
+
+14
+00:01:17,550 --> 00:01:20,750
+سبيل المثال الـ Herpes Simplex Lesion وبنصبغ وبـ
+
+15
+00:01:20,750 --> 00:01:25,170
+بنشوف Multinucleated Giant Cell. رقم ثلاثة: وهي 
+
+16
+00:01:25,170 --> 00:01:28,590
+متبعة في كل أنواع الـ .. الـ .. الاتحاد الطبية اللي
+
+17
+00:01:28,590 --> 00:01:32,670
+هو Serological Identification للتعرف على الـ IgG
+
+18
+00:01:32,670 --> 00:01:38,310
+أو الـ IgM، وهنا لابد من تمييز بين اثنين: الـ IgG يا 
+
+19
+00:01:38,310 --> 00:01:45,570
+بنات، بيختلف .. خدنا نقول قيمته التشخيصية عن الـ IgM
+
+20
+00:01:45,570 --> 00:01:50,730
+فلو افترضنا من هذا الـ time هنا الـ concentration الـ
+
+21
+00:01:50,730 --> 00:01:56,010
+concentration لمين؟ بتكون طبعًا للـ antibody، الـ IgM
+
+22
+00:01:56,010 --> 00:02:01,890
+غالباً بيصعد أولًا وبينتهي أيضًا أولًا، يعني وجوده
+
+23
+00:02:01,890 --> 00:02:07,590
+مرتبط ببداية من الـ infection بتضغط ومعشى لأنه فيه
+
+24
+00:02:07,590 --> 00:02:12,770
+recent infection، بينما الـ IgG، هذا اسمه IgM، IgG 
+
+25
+00:02:12,770 --> 00:02:17,490
+بيظهر، بيبدأ بالظهور أيضًا بنفس الدرجة أو بنفس الوقت
+
+26
+00:02:17,490 --> 00:02:25,150
+اللي بيظهر فيه الـ IgM، لكن بتركيز منخفض، وبعدين
+
+27
+00:02:25,150 --> 00:02:31,530
+بيرتفع بشكل أكبر وبستمر لوين؟ لفترة أطول، إذا IgG 
+
+28
+00:02:33,680 --> 00:02:38,140
+بيستمر كم يوم؟ لفترة أطول، بينما الـ IgM هو فقط
+
+29
+00:02:38,140 --> 00:02:45,880
+في فترة الذروة تبع الـ disease، لذلك وجود IgM مؤشر
+
+30
+00:02:45,880 --> 00:02:51,700
+لماذا؟ على recent infection، يعني الآن في عندنا عدوى
+
+31
+00:02:51,700 --> 00:02:59,600
+بينما الـ IgG كما نرى من الـ graph لو لاجيناها، يمكن
+
+32
+00:02:59,600 --> 00:03:05,590
+تكون نعم recent، ممكن تكون old، ممكن تكون ناتجة عن
+
+33
+00:03:05,590 --> 00:03:10,750
+vaccination أو ناتجة عن carrier state، لذلك لا يمكن
+
+34
+00:03:10,750 --> 00:03:17,350
+الاعتماد على الـ IgG لوحده في عملية التشخيص، أو يمكن
+
+35
+00:03:17,350 --> 00:03:25,710
+بطريقة ثانية. تعالوا الآن نلغي الـ IgM ونرجع
+
+36
+00:03:25,710 --> 00:03:32,590
+نعيد صياغة الجدول تبعنا أو أعفن الـ graph، هنا قولنا
+
+37
+00:03:32,590 --> 00:03:36,930
+الـ IgG بيستمر لفترات طويلة، بس إذا ما نصارش في
+
+38
+00:03:36,930 --> 00:03:43,030
+الأخر الصبورة، بنا نعود نختصرها لأن برضه القصة
+
+39
+00:03:43,030 --> 00:03:48,030
+الحقيقية هتبدأ مظبوط منخفضة وترتفع وبعدين تنزل
+
+40
+00:03:48,030 --> 00:03:53,710
+لكن على فترة أطول. لو جسنا تركيز الـ antibody في
+
+41
+00:03:53,710 --> 00:03:58,750
+لحظة لمرض ما ولجيناها 80 وأنت منين على الـ curve
+
+42
+00:03:58,750 --> 00:04:05,960
+هنا؟ الـ 80 هذه بدنا نلاحظ ملاحظة، لو أخذنا خط
+
+43
+00:04:05,960 --> 00:04:12,120
+مستقيم من عند الـ 80 ومشينا فيه بمساواة الـ time،
+
+44
+00:04:12,120 --> 00:04:17,500
+هيقطع الـ curve فيها كم نقطة؟ اثنتين، واحدة، اثنتين،
+
+45
+00:04:17,500 --> 00:04:22,410
+هذه الـ curve، الآن خدوا بالكم، هو نقطة كتير مهمة، الـ
+
+46
+00:04:22,410 --> 00:04:28,710
+curve من جهة طالع ومن جهة نازل، لا يتسنى للإنسان
+
+47
+00:04:28,710 --> 00:04:31,850
+في المختبر أو في الطب إنه يعرف هل هو طالع ولا نازل
+
+48
+00:04:31,850 --> 00:04:36,990
+ما بنقدرش نعرف عنه، فإيش بنعمل؟ بنعيد الفحص أو بنكرر
+
+49
+00:04:36,990 --> 00:04:42,790
+الفحص مرة أخرى خلال أكثر أيام، ten days أو two
+
+50
+00:04:42,790 --> 00:04:48,710
+weeks، يعني fourteen days. الآن لو قررنا قياس الـ IgG
+
+51
+00:04:48,710 --> 00:04:55,250
+بعد عشر إلى أربع عشر يوم، ولجينا المستوى صار 100،
+
+52
+00:04:55,250 --> 00:04:59,490
+إيش معناه 100؟ 100 فوق الـ 80، يبقى الـ 80
+
+53
+00:04:59,490 --> 00:05:05,280
+كانت في المنحنى الصاعد، يبقى الآن في عندنا Infection، لو
+
+54
+00:05:05,280 --> 00:05:10,320
+لجيناها كما هي 80 أو أقل من ذلك فهي على الجهة
+
+55
+00:05:10,320 --> 00:05:15,160
+الثانية اللي هي المنخفضة، وبالتالي ليس لها أي قيمة
+
+56
+00:05:15,160 --> 00:05:19,500
+تشخيصية سواء إن هذا الشخص كان في يوم من الأيام قد
+
+57
+00:05:19,500 --> 00:05:24,760
+تعرض لهذا الـ microbe. إذا الـ IgG والـ IgM، الـ value
+
+58
+00:05:24,760 --> 00:05:29,620
+تبعتهم في التشخيص بتختلف، الـ IgM هو confirmatory لـ
+
+59
+00:05:29,620 --> 00:05:32,860
+recent infection، بينما الـ IgG نحتاج إلى فحص آخر
+
+60
+00:05:32,860 --> 00:05:37,420
+حتى نقدر نستفيد منه. في كمان شغل كتير مهمة في الـ ..
+
+61
+00:05:37,420 --> 00:05:40,500
+الـ .. الـ approaches الخامسة اللي هو الرابع
+
+62
+00:05:40,500 --> 00:05:46,600
+detection of antigen in blood or body fluids، الآن
+
+63
+00:05:46,600 --> 00:05:50,560
+وجود antibody، احنا كنا جاب شوية لسه، قد لا يكون دليل
+
+64
+00:05:50,560 --> 00:05:55,490
+على recent infection، لكن وجود antigen ماذا يعني
+
+65
+00:05:55,490 --> 00:05:59,130
+antigen؟ يعني جزء من مين؟ من الفيروس أو الفيروس نفسه
+
+66
+00:05:59,130 --> 00:06:02,050
+أساسًا، فبعدها بحكي إنه أنا بتكلم على more
+
+67
+00:06:02,050 --> 00:06:05,810
+specific لـ الـ diagnosis، لو أنا لجيت اللي هو الـ
+
+68
+00:06:05,810 --> 00:06:11,730
+viral antigen. الآن الخامس يشبه الرابع إلى حد كبير،
+
+69
+00:06:11,730 --> 00:06:15,570
+إيش الخامس بيقول؟ بيقول detection of viral nucleic
+
+70
+00:06:15,570 --> 00:06:19,370
+acid، الـ DNA أو الـ RNA حسب نوع الفيروس في الـ serum
+
+71
+00:06:19,370 --> 00:06:23,650
+اللي هو الدم يعني أو في الـ cells تبع المريض، فعلى
+
+72
+00:06:23,650 --> 00:06:28,730
+النقطتين الأخرتين اللي هم الرابع والخامس، Detection
+
+73
+00:06:28,730 --> 00:06:31,630
+of Viral Antigen أو Detection of Viral Nucleic
+
+74
+00:06:31,630 --> 00:06:35,930
+Acid، كلا هما confirmatory test، من البداية إذا 
+
+75
+00:06:35,930 --> 00:06:38,730
+لجينا الـ antigen فما له الحاجة إن الفيروس موجود، إذا
+
+76
+00:06:38,730 --> 00:06:41,070
+لجينا الـ DNA أو الـ RNA فما له الحاجة إن الفيروس
+
+77
+00:06:41,070 --> 00:06:46,540
+موجود، قد يكون موجود وقد لا يكون موجود، لأن أنا بحث
+
+78
+00:06:46,540 --> 00:06:50,500
+عن الآثار اللي هو مين؟ الـ antibody، أحد الآثار هو
+
+79
+00:06:50,500 --> 00:06:53,760
+الآثار الحديثة اللي هو الـ IgM، وأحد الآثار الأخرى
+
+80
+00:06:53,760 --> 00:06:57,420
+اللي هو الـ IgG، آثار قديمة، وبالتالي أنا محتاج كنت
+
+81
+00:06:57,420 --> 00:07:03,560
+في الـ IgG أن أنا أكرر الفحص مرة أخرى. طيب الـ
+
+82
+00:07:03,560 --> 00:07:06,900
+identification في الـ cell culture، ويمكن العلامة
+
+83
+00:07:06,900 --> 00:07:10,560
+الفاصلة اللي ركزنا عليها من بداية الفصل هي الـ CPE
+
+84
+00:07:10,560 --> 00:07:17,640
+وقولنا الـ CPE كما هو معرف هنا في الفقرة أو في الصدر
+
+85
+00:07:17,640 --> 00:07:22,180
+الرابع، CPE is a change in the appearance، تغيير في
+
+86
+00:07:22,180 --> 00:07:26,960
+شكل الـ virus infected cells، خلايا المصابة بالفيروس
+
+87
+00:07:26,960 --> 00:07:33,330
+هذا التغيير قد يكون على شكل تغيير في الحجم، تغيير
+
+88
+00:07:33,330 --> 00:07:37,470
+في شكل الخلايا، تمام؟ أو عبارة عن ارتباط الخلايا
+
+89
+00:07:37,470 --> 00:07:40,330
+ببعضها البعض، نسميها fusion أو الـ syncytia
+
+90
+00:07:40,330 --> 00:07:44,290
+وجبنا مثال عليها اللي هو الـ respiratory syncytial
+
+91
+00:07:44,290 --> 00:07:48,530
+virus، وأيضًا الـ herpes virus عمل برضه syncytia في
+
+92
+00:07:48,530 --> 00:07:54,110
+هذه الحالة. الـ cytopathic effect يستخدم لما يسمى
+
+93
+00:07:54,110 --> 00:07:56,970
+بالـ presumptive identification، وكلمة presumptive
+
+94
+00:07:56,970 --> 00:08:00,310
+identification مرت معنا في أكثر من مكان في الـ
+
+95
+00:08:00,310 --> 00:08:03,520
+diagnostic microbiology، Presumptive معناها افتراضي
+
+96
+00:08:03,520 --> 00:08:07,540
+Presumptive معناها أولي، مبدأي، إيه؟ يعني مش .. مش
+
+97
+00:08:07,540 --> 00:08:12,660
+نهائي، ليس confirmatory، تمام؟ إذا هو Presumptive
+
+98
+00:08:12,660 --> 00:08:16,500
+Identification، ليش حطيناها في خانة الـ Presumptive؟
+
+99
+00:08:16,500 --> 00:08:20,600
+لأنه قد يكون هناك أكثر من نوع من الفيروسات بيعمل
+
+100
+00:08:20,600 --> 00:08:27,980
+the same CPE، لكن إذا كان الـ CPE unique، فريد لهذا
+
+101
+00:08:27,980 --> 00:08:31,860
+الفيروس، فممكن يرتقي بدل ما هو Presumptive
+
+102
+00:08:31,860 --> 00:08:36,020
+identification يصير Definitive diagnosis أو
+
+103
+00:08:36,020 --> 00:08:39,680
+Definitive identification، زي مين مثلًا؟ زي الـ Negri
+
+104
+00:08:39,680 --> 00:08:43,300
+body في اللي هو الـ rabies virus اللي موجود عندنا
+
+105
+00:08:43,300 --> 00:08:47,900
+intracytoplasmic bodies. الـ cytopathic effect
+
+106
+00:08:47,900 --> 00:08:54,840
+هو ما يحدث في الخلايا الميتة، ليش ماتت؟ Via the
+
+107
+00:08:54,840 --> 00:09:00,850
+infected cell أو الخلايا التي ستموت، يبقى dead or
+
+108
+00:09:00,850 --> 00:09:03,610
+dying cells هي اللي بتعمل الـ cytopathic effect
+
+109
+00:09:07,070 --> 00:09:10,210
+طيب، مش كل الفيروسات دي، هو الـ cell culture بتعمل
+
+110
+00:09:10,210 --> 00:09:13,030
+cytopathic effect، وشوفنا احنا لما تكلمنا عن الـ
+
+111
+00:09:13,030 --> 00:09:17,110
+replication يا بنات، كلمنا عن بعض الفيروسات بتعمل
+
+112
+00:09:17,110 --> 00:09:20,630
+budding، بتاخد جزء من الـ membrane تبع الـ cell
+
+113
+00:09:20,630 --> 00:09:24,970
+membrane تبع الـ host cell وبتطلع دون ما أن تؤثر
+
+114
+00:09:24,970 --> 00:09:28,650
+لها على شكل ولا على الـ metabolism تبع الخلية، الـ
+
+115
+00:09:28,650 --> 00:09:32,890
+bacteria، الخلية الـ host، فكيف لنا أن نتعرف على
+
+116
+00:09:32,890 --> 00:09:36,750
+virally infected cell ما بتعملش cytopathic effect؟
+
+117
+00:09:37,380 --> 00:09:41,200
+اللوحة هذه اللي أمامنا هي المعبر عن هذا الموضوع
+
+118
+00:09:41,200 --> 00:09:45,040
+رقم واحد: hem adsorption، والـ hem adsorption اللي
+
+119
+00:09:45,040 --> 00:09:51,240
+حقيقة محتاجين نتكلم عنها شوية، الـ
+
+120
+00:09:51,240 --> 00:09:56,040
+influenza لما صار فيها إن حادث مها الطيور
+
+121
+00:09:56,040 --> 00:10:02,700
+والخنازير، سمعتوا يمكن في الأخبار، برموز مشهورة H5
+
+122
+00:10:03,280 --> 00:10:11,580
+H1N1، H1N1، هدى الرموز انشهرت كثير، الـ H هذه جاية
+
+123
+00:10:11,580 --> 00:10:16,020
+من كلمة Hemagglutinin، Hemagglutinin، وإيش المعنى له
+
+124
+00:10:16,020 --> 00:10:22,660
+Hemagglutinin؟ إنه Antigen يستطيع الارتباط بمين؟ بـ red
+
+125
+00:10:22,660 --> 00:10:26,520
+blood cells، والـ Hemabsorption هو Hemagglutination 
+
+126
+00:10:26,520 --> 00:10:31,440
+بمعنى آخر دعونا نشوف لو احنا عندنا influenza virus
+
+127
+00:10:34,360 --> 00:10:42,220
+خذ بالك وهذا مهم مش لذاته لصفة أو لفحص لاحق، ليش 
+
+128
+00:10:42,220 --> 00:10:49,240
+مش مهم هو لذاته؟ هو صفة لكن ليست صفة مرتبطة بفيروس
+
+129
+00:10:49,240 --> 00:10:54,420
+واحد وأنا بمجموعة من الفيروسات فإن وددت هذه الصفة
+
+130
+00:10:54,420 --> 00:10:58,720
+فسأحدد المجموعة وأقول إن هذه الفيروسات هي
+
+131
+00:10:58,720 --> 00:11:03,300
+المحتملة لكن لا يعصتيها أن أحدد من الفيروس أو ال
+
+132
+00:11:03,300 --> 00:11:05,000
+specific مثلا عندي
+
+133
+00:11:22,210 --> 00:11:23,610
+مممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممممم
+
+134
+00:11:29,800 --> 00:11:32,840
+في منها ما يمتلك الصفة تقولنا اللي هي absorption
+
+135
+00:11:32,840 --> 00:11:37,120
+أو الارتباط بالـ blood cell لو كان الفيروس أو
+
+136
+00:11:37,120 --> 00:11:41,340
+مجموعة فيروسات موجودة وموجودة عند blood cells، إيش
+
+137
+00:11:41,340 --> 00:11:46,050
+بيعمل في blood cell؟ هيرتبط فيها لما يرتبط فيها هو
+
+138
+00:11:46,050 --> 00:11:51,670
+حجمه صغير الـ virus حجمه صغير جدا جدا بالمقارنة مع
+
+139
+00:11:51,670 --> 00:11:55,430
+مين؟ مع red blood cell ففيروس صغير بيربط له أربع
+
+140
+00:11:55,430 --> 00:11:58,470
+خمس خلايا ليش بيعمل فيهم؟ بيجمعهم ففيروس ثاني
+
+141
+00:11:58,470 --> 00:12:01,670
+بيرتبط في خلية من الخلايا المرتبطة بيجمع كمان خمسة
+
+142
+00:12:01,670 --> 00:12:06,450
+ستة فبعطيني مجموعة من الخلايا مرتبطة بعضها بنسميها
+
+143
+00:12:06,450 --> 00:12:10,780
+agglutination أو adsorption الآن وجود هذه الخاصية
+
+144
+00:12:10,780 --> 00:12:14,120
+في بعض الفيروسات بتساعدنا في التعرف عليها وصلت
+
+145
+00:12:14,120 --> 00:12:19,260
+صورة him adsorption لكن عشان في عندي أكثر من اسم
+
+146
+00:12:19,260 --> 00:12:23,700
+بيقوم بنفس المهمة فلن أستطيع أن أحدد specifically
+
+147
+00:12:23,700 --> 00:12:28,660
+اسم هذا الفيروس نجي لنقطة ثانية interference والـ
+
+148
+00:12:28,660 --> 00:12:30,960
+interference أيضا بده توضيح
+
+149
+00:12:36,710 --> 00:12:39,250
+الهي لو عندي virally infected cell .. virally
+
+150
+00:12:39,250 --> 00:12:42,850
+infected cell دخل فيها فيروس أنتم عارفين أن
+
+151
+00:12:42,850 --> 00:12:47,530
+الفيروس اللي دخل هذا بيحاول وبيمتلك القدرة على
+
+152
+00:12:47,530 --> 00:12:51,290
+أنه يحصن الخلية اللي دخل جواها من الغذاء الآخرين
+
+153
+00:12:51,290 --> 00:12:56,370
+فدخوله في الخلية بيمنع غالبا other viruses إلا إذا
+
+154
+00:12:56,370 --> 00:12:59,910
+كانوا دخلوا اثنين إيه مع بعض في نفس اللحظة تزعموا
+
+155
+00:12:59,910 --> 00:13:02,950
+يعني صار في synchronization لكن واقعا هو إذا
+
+156
+00:13:02,950 --> 00:13:06,570
+الفيروس دخل جوا خلية بيمنع آخرين إنهم يدخلوا جوا
+
+157
+00:13:06,570 --> 00:13:11,890
+هذه الخلية طيب أنا عندي فيروس احنا نأخذ بالكل واحد
+
+158
+00:13:11,890 --> 00:13:14,210
+اللي بنشرح فيها جديد هذه إيش مالها نتكلم عن
+
+159
+00:13:14,210 --> 00:13:16,890
+فيروسات ما بتعملش cytopathic effect ما بتعملش
+
+160
+00:13:16,890 --> 00:13:20,330
+cytopathic effect أحد الطرق اللي ممكن من خلالها
+
+161
+00:13:20,330 --> 00:13:23,130
+نكتشف عن هذه الفيروسات اللي مرضها لغير موجودة
+
+162
+00:13:23,130 --> 00:13:26,430
+بنضيف على الـ cell culture على الـ cell culture
+
+163
+00:13:26,430 --> 00:13:30,370
+فيروس من عندنا احنا عارفين إنه بيعمل cytopathic
+
+164
+00:13:30,370 --> 00:13:35,310
+effect لو ما فيش فيروس نامي في الخلايا، الفيروس
+
+165
+00:13:35,310 --> 00:13:38,470
+الجديد اللي حاطه شماله، هيعمل Cytopathic Effect،
+
+166
+00:13:38,470 --> 00:13:42,550
+بس إذا فيروس already موجود وعمل Infection، هيعمل
+
+167
+00:13:42,550 --> 00:13:46,470
+Interference، هيمنع الفيروس اللي أنا قدعته الجديد
+
+168
+00:13:46,470 --> 00:13:49,430
+من إنه يكون Cytopathic Effect، يبقى عرفت إنه في
+
+169
+00:13:49,430 --> 00:13:53,790
+فيروس في الخلايا هذه نتيجة إيه؟ إنه ما تكونش
+
+170
+00:13:53,790 --> 00:13:57,930
+Cytopathic Effect من خلال صفة الـ Interference
+
+171
+00:13:58,640 --> 00:14:02,620
+النقطة الثالثة وهي أيضا نقطة جميلة نسميها decrease
+
+172
+00:14:02,620 --> 00:14:09,480
+in acid production يفترض .. يفترض أن الخلايا
+
+173
+00:14:09,480 --> 00:14:15,740
+العادية وأنا لحد الآن ما وردكوش أي وسيلة لتنمية الـ
+
+174
+00:14:15,740 --> 00:14:16,800
+cell culture
+
+175
+00:14:20,350 --> 00:14:23,690
+بتعرفوا الـ petri dish تبعنا إيش بيكون لونه بيظهر
+
+176
+00:14:23,690 --> 00:14:28,690
+شفاف شفاف عندي bottles أيضا شفافة بيه هذا الشكل
+
+177
+00:14:28,690 --> 00:14:31,850
+وأنا أرجو من حضراتكم لما تروحوا على معمل الفيروسات
+
+178
+00:14:31,850 --> 00:14:38,110
+تطلبوا من المسات إنهم يوريوكوا حاجتين في أقرب فرصة
+
+179
+00:14:38,110 --> 00:14:41,810
+اللي هو الـ bottles ها دي وده كان فيه عندهم سيل
+
+180
+00:14:41,810 --> 00:14:45,290
+culture جاهزة يوريوكوا إياها وحاجة ثانية اسمها
+
+181
+00:14:45,290 --> 00:14:50,230
+inverted microscope inverted microscope الآن عشان
+
+182
+00:14:50,230 --> 00:14:52,690
+نفهم الـ inverted microscope والـ cell culture
+
+183
+00:14:52,690 --> 00:14:56,650
+دلوقت طلع البطل هذه البطل هذه بنحط فيها احنا
+
+184
+00:14:56,650 --> 00:14:59,030
+sterile media
+
+185
+00:15:00,900 --> 00:15:04,780
+مش مقنكي و blood agar ميديا لمن؟ للـ cells للخلايا
+
+186
+00:15:04,780 --> 00:15:09,380
+وبنحط cells الآن الـ cells بتكون عادتها قليلة لكن
+
+187
+00:15:09,380 --> 00:15:13,940
+كونه فيه ميديا بتبدأ تتكاثر الخلايا وما بتكون
+
+188
+00:15:13,940 --> 00:15:17,980
+organ ولا بتكون tissue بتكون حاجة بنسميها احنا
+
+189
+00:15:17,980 --> 00:15:23,000
+mono layer طبقة واحدة من الخلايا إذا بكون في عندي
+
+190
+00:15:23,000 --> 00:15:27,760
+single layer من الخلايا على السطح السفلي لحظة لو
+
+191
+00:15:27,760 --> 00:15:30,860
+حطيناها تحت الـ microscope هذه سمكة تقريبا هالجدر
+
+192
+00:15:31,930 --> 00:15:35,690
+أنه عدسة بتاعت طلع عليها ولا واحدة منهم صح ولا لأ؟
+
+193
+00:15:35,690 --> 00:15:39,790
+المسافة اللي بين الشيئية وبين الـ microscope قصيرة
+
+194
+00:15:39,790 --> 00:15:44,970
+لن تتسع أصلا لهذا الطبق فكيف بنفحصها؟ بنعمل
+
+195
+00:15:44,970 --> 00:15:48,950
+microscope مجلوب كيف microscope مجلوب؟ هاي البطل،
+
+196
+00:15:48,950 --> 00:15:51,690
+هاي المسرح اللي هو الـ stage عارفين الـ stage؟ هاي
+
+197
+00:15:51,690 --> 00:15:55,230
+الفتحة، هاي العدسات الشيئية
+
+198
+00:15:59,160 --> 00:16:03,020
+وهي الـ revolver تبعها وبيلاقي low power و high
+
+199
+00:16:03,020 --> 00:16:05,120
+power ولأ بس high power ما فيش لإن هو really
+
+200
+00:16:05,120 --> 00:16:08,780
+merchant في هذا الحلق تمام؟ وطبعا هذا بيكون مشبوك
+
+201
+00:16:08,780 --> 00:16:13,500
+وبيروح على اللي هو العيني يعني هو جرد أنه بدل
+
+202
+00:16:13,500 --> 00:16:17,940
+مكان العدسات من فوق سادة سادة من تحت والإضاءة
+
+203
+00:16:17,940 --> 00:16:22,080
+صارت من وين؟ من فوق فاسمه inverted microscope طبعا
+
+204
+00:16:22,080 --> 00:16:25,640
+المسافة بين الخلالة وبين العدسة مقبولة وليس
+
+205
+00:16:25,640 --> 00:16:28,800
+مقبولة المسافة مقبولة المسافة يبقى الـ inverted
+
+206
+00:16:28,800 --> 00:16:33,320
+microscope هو اللي يستخدم لمين؟ لرؤية الـ cell
+
+207
+00:16:33,320 --> 00:16:35,600
+culture ولفحص الـ cell culture مش الميكروسكوب
+
+208
+00:16:35,600 --> 00:16:39,530
+العادي هذه نقطة طبعا أنا inverted microscope وأنا
+
+209
+00:16:39,530 --> 00:16:42,470
+اللي هو الـ .. الـ .. الـ .. الـ culture بتلت بس مش
+
+210
+00:16:42,470 --> 00:16:45,570
+متأكد أن أنا الآن في الوقت الحالي لديهم cell line
+
+211
+00:16:45,570 --> 00:16:48,990
+شغالة إذا ما فيش هنحاول نملكوا cell line أو اثنتين
+
+212
+00:16:48,990 --> 00:16:53,130
+نتفرج عليها طيب كنا بتكلم عن مين احنا؟ نتكلم عن
+
+213
+00:16:53,130 --> 00:16:57,730
+decrease in acid production طلعولي على الخلايا
+
+214
+00:16:57,730 --> 00:17:03,030
+اللي هي normal cells اللي هي حضرتها أنا افترضوا أن
+
+215
+00:17:03,030 --> 00:17:07,030
+أنا نميتها وما وضعت عليها أي عينة فهي sterile
+
+216
+00:17:08,120 --> 00:17:12,900
+الخلايا وهي بتنمو وبتتكاثر بتنتج acid الـ acid
+
+217
+00:17:12,900 --> 00:17:19,560
+هذا بيظل يزداد يزداد بنمو الخلايا كيف بعرف إنه في
+
+218
+00:17:19,560 --> 00:17:23,560
+acid ولا ما فيش acid أنا حاطط في الوسط pH indicator
+
+219
+00:17:23,560 --> 00:17:28,460
+اللي اسمه phenol red في هذا العبارة phenol red
+
+220
+00:17:28,460 --> 00:17:33,470
+indicator الـ phenol red indicator لما بينخفض الـ pH
+
+221
+00:17:33,470 --> 00:17:39,030
+بتحول لونه من زهري أو من أحمر إلى yellow إلى أصفر،
+
+222
+00:17:39,030 --> 00:17:45,370
+الآن أنا مش حاطط فيروس واتحولت إلى أصفر، معناه
+
+223
+00:17:45,370 --> 00:17:49,730
+حاجة الخلايا شغالة كويس إنها بتتم وبتتكاثر وما في
+
+224
+00:17:49,730 --> 00:17:55,030
+أي فيروس، لكن لو حطيت أنا عليها عينة وما اتحولتش
+
+225
+00:17:55,030 --> 00:17:59,540
+للون الأصفر، ماذا يعني ذلك؟ يعني أن الخلايا بدأت
+
+226
+00:17:59,540 --> 00:18:03,540
+أشمالها تضعف وتموت وما فيش فيها metabolism، هذه
+
+227
+00:18:03,540 --> 00:18:07,120
+مؤشر على ماذا؟ على أن الفيروس عامل infection في
+
+228
+00:18:07,120 --> 00:18:12,120
+هذه الخلايا، إذا انكشفت عن وجود فيروس في هذا الـ
+
+229
+00:18:12,120 --> 00:18:16,350
+cell culture من خلال إنخفاض في إنتاج الـ acid اللي
+
+230
+00:18:16,350 --> 00:18:19,190
+هو الـ normal، إنتاج الـ normal اللي بتنتجله
+
+231
+00:18:19,190 --> 00:18:21,890
+الخلايا الطبيعية، إذا hem absorption،
+
+232
+00:18:21,890 --> 00:18:24,970
+interference، decrease in acid production،
+
+233
+00:18:24,970 --> 00:18:27,150
+بالإضافة إلى الـ cytopathic effect اللي شفناه في
+
+234
+00:18:27,150 --> 00:18:31,990
+اللوحة السابقة هذا كله بيندرج تحت قولنا مين؟
+
+235
+00:18:31,990 --> 00:18:35,490
+Presumptive Identification الآن نتكلم عن مين؟ عن
+
+236
+00:18:35,490 --> 00:18:39,010
+Definitive Identification كلمة Definitive يعني
+
+237
+00:18:39,010 --> 00:18:43,570
+مؤكد أو confirmed diagnosis واحنا الحقيقة دائما
+
+238
+00:18:43,570 --> 00:18:48,330
+نسعى إلى أن التعريف للبكتيريا أو الفطريات أو
+
+239
+00:18:48,330 --> 00:18:52,010
+الفيروسات أو البرازايت to be specific لغرضين
+
+240
+00:18:52,010 --> 00:18:57,380
+رئيسيين إيش الغرض الأول؟ الغرض الأول إنه الـ
+
+241
+00:18:57,380 --> 00:19:00,620
+definitive diagnosis بيعطيني accurate epidemiology
+
+242
+00:19:00,620 --> 00:19:04,960
+في المستقبل الآن لو أسأل السؤال كم حالة herpes
+
+243
+00:19:04,960 --> 00:19:08,020
+simplex type 1 في فلسطين ولا واحد بقدر يعطيني
+
+244
+00:19:08,020 --> 00:19:11,160
+إجابة لأن لا في أصلا لا في presentive ولا في
+
+245
+00:19:11,160 --> 00:19:13,780
+definitive diagnosis في هذا المجال المجال
+
+246
+00:19:13,780 --> 00:19:17,820
+الفيروسات جونالكو من أضعف المجالات الموجودة في
+
+247
+00:19:17,820 --> 00:19:23,140
+القطع مجموعة من الفحوصات السيرولوجية أو
+
+248
+00:19:23,140 --> 00:19:28,590
+الإلكترونية لكن كلها مرتبطة بـ принцип الواحد إيش هو
+
+249
+00:19:28,590 --> 00:19:33,990
+الـ принцип الواحد ده وجود specific non-antibody
+
+250
+00:19:33,990 --> 00:19:39,530
+وكلمة non-antibody أنتم عرفتوها بكلمة monoclonal
+
+251
+00:19:39,530 --> 00:19:44,470
+antibody صح؟ ايش عكس monoclonal؟ ايش الفرق بين
+
+252
+00:19:44,470 --> 00:19:49,710
+التانين؟
+
+253
+00:19:49,710 --> 00:19:55,790
+الـ monoclonal is specific to only one epitope الآن
+
+254
+00:19:55,790 --> 00:19:59,710
+أنا بدي أفترض افتراضًا وأرجو أنكم تجيالوني في هذا
+
+255
+00:19:59,710 --> 00:20:03,150
+الافتراض أن هو اللي مبني عليه أساسًا الفكرة تبع كل
+
+256
+00:20:03,150 --> 00:20:07,660
+الفحوصات وهو أن الـ antibody specific يعني الـ
+
+257
+00:20:07,660 --> 00:20:11,380
+antibody لا يرتبط إلا بالـ antigen هذا الافتراض مش
+
+258
+00:20:11,380 --> 00:20:15,900
+hundred percent accurate لكن لغرض الفهم والشرح
+
+259
+00:20:15,900 --> 00:20:20,780
+الآن نفترض أنه very specific عندي non-antibody 
+
+260
+00:20:20,780 --> 00:20:25,840
+ارتبط بالـ non-virus ما الذي يعني ذلك بالنسبة لكم؟
+
+261
+00:20:25,840 --> 00:20:29,840
+أن الـ virus صار non مدام أن الـ antibody non و
+
+262
+00:20:29,840 --> 00:20:35,670
+specific يبقى صار الـ virus non أيضًا إذا كل الفحوصات
+
+263
+00:20:35,670 --> 00:20:40,630
+التي سنذكرها مرتبطة بمين؟ بفكرة أنه non-specific
+
+264
+00:20:40,630 --> 00:20:45,050
+antibody عندي فحص الـ Complement Fixation وأنتم
+
+265
+00:20:45,050 --> 00:20:47,730
+خبرة أكيد صرتم في هذا الفحص ومع ذلك هنشرحه
+
+266
+00:20:47,730 --> 00:20:52,590
+Hemagglutination Inhibition وهنقول لكم لما قلنا لكم
+
+267
+00:20:52,590 --> 00:20:56,030
+تذكروا الـ Hem Absorption قلنا لكم هي ليست مهمة
+
+268
+00:20:56,030 --> 00:21:00,390
+بذاتها وإنما مهمة لأن في فحص ثاني معتمد عليها اللي
+
+269
+00:21:00,390 --> 00:21:03,870
+هو اسمه Hemagglutination Inhibition وهشرح لكم ده
+
+270
+00:21:03,870 --> 00:21:08,270
+بتفصيل إن شاء الله Neutralization of a CPE CPE
+
+271
+00:21:08,270 --> 00:21:14,220
+معروف للفيروس أو لمجموعة فيروسات حطيت الـ antibody
+
+272
+00:21:14,220 --> 00:21:21,040
+على الـ cell culture فمنع الـ CPE ليش منع الـ CPE؟
+
+273
+00:21:21,040 --> 00:21:25,160
+لأنه هو ارتبط بمين؟ بالفيروس وكونه ارتبط بالفيروس
+
+274
+00:21:25,160 --> 00:21:29,300
+ومنع الـ CPE بجهود specific وعرفنا أنه ده طبعًا
+
+275
+00:21:29,300 --> 00:21:31,900
+ممكن نلاقي كمان مجموعة كبيرة من الفحوصات زي الـ
+
+276
+00:21:31,900 --> 00:21:35,350
+fluorescent الـ Antibody Test، الـ Radio
+
+277
+00:21:35,350 --> 00:21:37,890
+Immunoassay، الـ Enzyme-Linked Immunosorbent
+
+278
+00:21:37,890 --> 00:21:41,450
+Assay، الـ ELISA، والـ Immune Electron Microscopy،
+
+279
+00:21:41,450 --> 00:21:45,110
+وسنطرح لهم واحد واحد إن شاء الله الـ Complement
+
+280
+00:21:45,110 --> 00:21:51,440
+Fixation هي فحص يعني أصبح من التاريخ تقريبًا يعني
+
+281
+00:21:51,440 --> 00:21:55,980
+إحنا بندرسه لأن الفكرة تبعته حلوة وجميلة لكن لم
+
+282
+00:21:55,980 --> 00:22:00,020
+يعود له استخدام لأن في كثير فحوصات أخرى أسهل منه
+
+283
+00:22:00,020 --> 00:22:05,040
+وفاقته في الـ simplicity وفاقته أيضًا في الـ
+
+284
+00:22:05,040 --> 00:22:08,760
+sensitivity والـ specificity لكن بندرسه كمان مرة
+
+285
+00:22:08,760 --> 00:22:14,600
+من أجل الفكرة العامة تبعته تعليمية لما أنا بكون
+
+286
+00:22:14,600 --> 00:22:21,830
+عندي antigen وبحط عليه antibody وكلاهما .. كلاهما
+
+287
+00:22:21,830 --> 00:22:25,450
+حجمه صغير ولو ارتبطا مع بعض يا جماعة أنا لا
+
+288
+00:22:25,450 --> 00:22:29,010
+أستطيع رؤيتهما ولا يمكن نقدر نعمل detection للـ
+
+289
+00:22:29,010 --> 00:22:33,410
+reaction أنه حدث أم لم يحدث تمام؟ الآن خذوا بالكم
+
+290
+00:22:33,410 --> 00:22:37,170
+في فرق بين الـ compliment fixation اللي عملناها من
+
+291
+00:22:37,170 --> 00:22:39,850
+الـ serum تبع المريض وفي فرق بين الـ compliment
+
+292
+00:22:39,850 --> 00:22:43,230
+fixation اللي عملها من مين؟ من الـ cell culture ايش
+
+293
+00:22:43,230 --> 00:22:48,370
+الفرق بينهما؟ أنه في الـ Serum أصلاً فيه complement
+
+294
+00:22:48,370 --> 00:22:52,530
+بس في الـ cell culture مافيش complement يبقى أنا
+
+295
+00:22:52,530 --> 00:22:55,470
+لازم أضيف لهما الـ antigen، الـ antibody اللي عشان
+
+296
+00:22:55,470 --> 00:23:00,070
+لازم أضيف عليهم مية إن أنا، complement إذا الـ
+
+297
+00:23:00,070 --> 00:23:03,370
+antigen والـ antibody والـ complement والثلاثة أنا
+
+298
+00:23:03,370 --> 00:23:07,290
+للحقيقة لا أستطيع رؤية ما الذي حصل إذا اتحد الـ
+
+299
+00:23:07,290 --> 00:23:11,170
+antigen مع الـ antibody الـ complement هتستهلك إذا لم
+
+300
+00:23:11,170 --> 00:23:14,390
+يتحد الـ antigen مع الـ antibody الـ compliment هتبقى
+
+301
+00:23:14,390 --> 00:23:17,850
+لكن أنا الصيني مش قادر أعرف هذا الكلام فمضطر أنا
+
+302
+00:23:17,850 --> 00:23:24,730
+أعمل system جديد اسمه RBCs synthesized with
+
+303
+00:23:24,730 --> 00:23:30,250
+antibody هذا الـ antibody ينتظر حاجة واحدة ينتظر
+
+304
+00:23:30,250 --> 00:23:37,170
+وجود complement حتى يذيب الـ RBC ويدمرها أنا حاطه
+
+305
+00:23:37,170 --> 00:23:40,780
+بدون complement أخذته وحطيته على الـ system تبعيها
+
+306
+00:23:40,780 --> 00:23:45,380
+على الفحص تبعيها بعد فترة ودي إزالة جيت إنه الدم
+
+307
+00:23:45,380 --> 00:23:49,300
+اللي حطيته اتحلل صار له hemolysis عارفينش يعني
+
+308
+00:23:49,300 --> 00:23:53,620
+hemolysis؟ يعني اتكسرت الـ RBCs ليش اتكسرت الـ RBCs؟
+
+309
+00:23:53,620 --> 00:23:56,160
+لأنه فيه complement بعدين في complement يبقى الـ
+
+310
+00:23:56,160 --> 00:23:59,600
+antigen والـ antibody مرتبطوش مع بعض إذا لما يكون
+
+311
+00:23:59,600 --> 00:24:04,380
+في hemolysis result
+
+312
+00:24:04,380 --> 00:24:08,160
+negative no hemolysis
+
+313
+00:24:12,460 --> 00:24:17,700
+الفحص positive ليش no hemolysis؟ لأن مافيش
+
+314
+00:24:17,700 --> 00:24:20,240
+compliment مافيش compliment وأنا حاط الـ
+
+315
+00:24:20,240 --> 00:24:23,780
+compliment ماها إحنا اللي حاطيناها استهلكاته بيه الـ
+
+316
+00:24:23,780 --> 00:24:26,920
+antigen antibody reaction وهذا ما يثبت بالـ
+
+317
+00:24:26,920 --> 00:24:29,260
+compliment fixation test وأنا حاط هنا صورة
+
+318
+00:24:29,260 --> 00:24:32,740
+توضيحية ده اللي ما استواش يعني شكل كبير ممكن تطلع
+
+319
+00:24:32,740 --> 00:24:38,620
+عليها إن شاء الله هتوضح لنا
+
+320
+00:24:38,620 --> 00:24:45,060
+الفكرة بتاعة الفحص الفحص الثاني هي Hemagglutination
+
+321
+00:24:45,060 --> 00:24:48,400
+Inhibition وهذا الفحص صحيح فحص كويس ويمكن أن أنا قبل
+
+322
+00:24:48,400 --> 00:24:52,020
+عدة سنوات أعمل training course لوزارة الصحة بس في
+
+323
+00:24:52,020 --> 00:24:56,560
+هذا الفحص عندما كان هناك تفشي ليه؟ لو ما influenza
+
+324
+00:24:56,560 --> 00:25:00,600
+الطيور وكانت موظبة الـ ..الغذاء والدواء دعم مشروع
+
+325
+00:25:00,600 --> 00:25:06,700
+لتقصي اللي هو الوباء في قطاع غزة من خلال فحوصات من
+
+326
+00:25:06,700 --> 00:25:10,700
+ضمنها كان فحص اللي هو الـ HIA والزملاء كانوا في
+
+327
+00:25:10,700 --> 00:25:14,660
+الوزارة ما عندهمش اطلاع على الفكرة فعملنا لهم
+
+328
+00:25:14,660 --> 00:25:18,320
+training في هذا الفحص الفكرة تبعه كانت تالية
+
+329
+00:25:19,740 --> 00:25:22,940
+الأنفلوانزا سميتها اسمها أنتم قبل قليل من ضمن
+
+330
+00:25:22,940 --> 00:25:26,500
+الفيروسات التي تقوم بعمل hem absorption أو hem
+
+331
+00:25:26,500 --> 00:25:30,840
+agglutination صح؟ ضمن الـ parainfluenza والـ mumps
+
+332
+00:25:30,840 --> 00:25:35,760
+وكان جونها الـ influenza virus الآن كونها واحد من
+
+333
+00:25:35,760 --> 00:25:40,400
+مجموعة بتعمل hem agglutination لن أستطيع أن أتعرف
+
+334
+00:25:40,400 --> 00:25:45,420
+عليها بدقة إلا من خلال antibody وايه الـ antibody
+
+335
+00:25:45,420 --> 00:25:47,460
+بتبدأ أعمل؟ تعالوا نطلع على اللوحة هذه
+
+336
+00:25:50,690 --> 00:25:56,910
+شوفوا الـ RBCs زائد الـ antibody زائد من الـ virus
+
+337
+00:25:56,910 --> 00:26:01,610
+itself الآن أنا عندي ايش الـ reaction وايه العينة
+
+338
+00:26:01,610 --> 00:26:07,070
+العينة هي ما يحتوي الفيروس أو ما يحتوي على الفيروس
+
+339
+00:26:07,070 --> 00:26:11,810
+إما cell culture أو عينة من إفرازات الدواجن
+
+340
+00:26:11,810 --> 00:26:15,210
+المصابة تمام هي اللي ممكن تكون محتوى على مين؟ على
+
+341
+00:26:15,210 --> 00:26:20,490
+الفيروس ومن عندي أنا بتضيف مين؟ antibody لكن بتضيف
+
+342
+00:26:20,490 --> 00:26:25,530
+معاها insulin antibody لو ضفت الـ RBC على الفيروس
+
+343
+00:26:25,530 --> 00:26:30,790
+ايش هيسوي؟ agglutination طب لو ضفت الـ antibody مع الـ
+
+344
+00:26:30,790 --> 00:26:35,230
+RBCs، الـ antibodies هترتبط مع الفيروس، لحظة هنا،
+
+345
+00:26:35,230 --> 00:26:40,670
+هتمنعين كمان الآن؟ هتمنع الـ RBCs من الارتباط، إذا
+
+346
+00:26:40,670 --> 00:26:44,730
+هو ايش اسم الفحص؟ Hemagglutination Inhibition،
+
+347
+00:26:44,730 --> 00:26:48,690
+Hemagglutination Inhibition، أنا منعت ارتباط الـ
+
+348
+00:26:48,690 --> 00:26:52,950
+RBCs من خلال ماذا؟ من خلال specific antibodies
+
+349
+00:26:52,950 --> 00:26:57,210
+واحنا قلنا كل الـ definitive diagnosis معتمد
+
+350
+00:26:57,210 --> 00:27:02,050
+بالأساس على مين؟ على non-specific antibody
+
+351
+00:27:02,050 --> 00:27:05,510
+neutralization
+
+352
+00:27:05,510 --> 00:27:12,090
+قلنا قبل شوية برضه أن الـ CPE يمكن أن يمنع من خلال
+
+353
+00:27:12,090 --> 00:27:17,330
+specific antibodies كيف؟ أخذنا عند cell culture
+
+354
+00:27:22,780 --> 00:27:25,120
+مش عارف فيها فيروس أو مافيش فيها فيروس أو ما حطيها
+
+355
+00:27:25,120 --> 00:27:29,020
+عينة والفيروس هذا بيعملش CPE بيعملش أو بيعمل عفوا
+
+356
+00:27:29,020 --> 00:27:33,620
+هذا من النوع اللي بيعمل CPE بيعمل CPE أخدت من
+
+357
+00:27:33,620 --> 00:27:40,040
+العينة من هنا وحطيتها في نفس الـ media نفس الـ
+
+358
+00:27:40,040 --> 00:27:44,200
+cells بس في bottle ثانية أخدت عينة من هنا كمان مرة
+
+359
+00:27:44,200 --> 00:27:48,920
+العينة مش بيكون فيها الفيروس اللي فيه CPE
+
+360
+00:27:51,590 --> 00:27:56,510
+ضفت جزء منه هنا وضفت specific antibody أو
+
+361
+00:27:56,510 --> 00:28:03,110
+antibodies ضفتهم مع بعض الآن إذا الـ antibody منع
+
+362
+00:28:03,110 --> 00:28:10,250
+تكون الـ CPE بيكون specific لمن؟ للـ antibody
+
+363
+00:28:10,250 --> 00:28:14,450
+specific للفيروس وبما أن الـ antibody معروف تمام
+
+364
+00:28:14,450 --> 00:28:18,840
+يبقى الفيروس أصبح الآن برضه معروف إلا إذا القضية
+
+365
+00:28:18,840 --> 00:28:23,640
+كلها مرتبطة بأشكال مختلفة ملونة تمام وهذه الصورة
+
+366
+00:28:23,640 --> 00:28:28,620
+بتوضح لنا كمان إنه كيف بينمنع اللي هو موضوع الـ CPE
+
+367
+00:28:28,620 --> 00:28:33,820
+بينمنع من خلال إنه هاي الـ virus كل نقاط التماس
+
+368
+00:28:33,820 --> 00:28:40,240
+اللي ممكن هو من خلالها يرتبط بالخلية الـ host صار
+
+369
+00:28:40,240 --> 00:28:44,160
+لها neutralization أو blocking يبقى الفيروس لن
+
+370
+00:28:44,160 --> 00:28:47,540
+يستطيع أصلاً أن يدخل داخل الخلايا مش هيقدر يعملها
+
+371
+00:28:47,540 --> 00:28:50,760
+infection مش هيقدر يعملها cytopathic effect
+
+372
+00:28:54,060 --> 00:28:57,760
+Fluorescent Antibody Test الـ Fluorescent Antibody
+
+373
+00:28:57,760 --> 00:29:01,420
+كلكم بتعرفوا أنه الـ Antibody could be conjugated
+
+374
+00:29:01,420 --> 00:29:05,140
+Conjugated يعني ممكن نربط عليه تفهم نربط عليه شيء
+
+375
+00:29:05,140 --> 00:29:09,040
+إما بإنزيم أو بـ Fluorescent أو بـ Radio Label يبقى 
+
+376
+00:29:09,040 --> 00:29:15,440
+فينا طرق متنوعة لربط مراكبات مختلفة على ال
+
+377
+00:29:15,440 --> 00:29:20,120
+Antibody على الـ Fc portion بالذات مادة 
+
+378
+00:29:20,120 --> 00:29:26,420
+فلورسنتية مادة radioactive إلخ ماذا غرب من رابط
+
+379
+00:29:26,420 --> 00:29:31,920
+المراكبات المختلفة على الـ Antibody والنفطة الواحد
+
+380
+00:29:31,920 --> 00:29:35,240
+منها اللي هو الـ fluorescent طبعا على اللوحة اللي
+
+381
+00:29:35,240 --> 00:29:41,120
+أمامكم، لو حالة ماكم هي عبارة عن خلايا مختلفة، أربع
+
+382
+00:29:41,120 --> 00:29:44,340
+أنواع من الخلايا، من الـ cell culture، تحت
+
+383
+00:29:44,340 --> 00:29:47,680
+الميكروسكوب الـ ultraviolet light، إيش اللون اللي
+
+384
+00:29:47,680 --> 00:29:53,020
+شايفينه؟ أخضر، مظبوط؟ لأن هذه صبغت بـ Antibodies،
+
+385
+00:29:53,020 --> 00:29:59,270
+صبغت بـ Antibodies، الـ Antibody بتصبغ؟ لكن عليها
+
+386
+00:29:59,270 --> 00:30:02,530
+مين؟ فلوريسين، فاحنا بنقول كواكب المبنى مالي
+
+387
+00:30:02,530 --> 00:30:05,350
+Staining لأنه إحنا غيرنا اللون، من لون Colorless
+
+388
+00:30:05,350 --> 00:30:09,450
+إلى لون آخر، شايفين؟ إحنا لقينا لون أخضر، فحطينا
+
+389
+00:30:09,450 --> 00:30:13,410
+عليها Antibodies تمام؟ Fluorescent Labeled، إذا 
+
+390
+00:30:13,410 --> 00:30:18,050
+الفيروس موجود، الـ Antibody هيرتبط بهذا الفيروس
+
+391
+00:30:18,990 --> 00:30:23,610
+بنعمل عملية غسيل للعينة عشان أي شيء مش مرتبط يشاله
+
+392
+00:30:23,610 --> 00:30:28,030
+يروح، وبناخد الـ .. الـ .. الـ .. السلسة بعتناها
+
+393
+00:30:28,030 --> 00:30:29,490
+وبنطلع عليها تحت الـ .. الـ .. الـ fluorescent
+
+394
+00:30:29,490 --> 00:30:31,970
+microscope، الـ fluorescent microscope بيقولنا إيش
+
+395
+00:30:31,970 --> 00:30:34,650
+بيسوي؟ بيطلع .. بيجينا إضاءة من فوق، إيش نوع
+
+396
+00:30:34,650 --> 00:30:39,970
+الإضاءة؟ UV تسقط على الشريحة، إذا كان في
+
+397
+00:30:39,970 --> 00:30:45,370
+fluorescent substance بينتص الإضاءة و بيطلعلي
+
+398
+00:30:45,370 --> 00:30:49,150
+visible light، ضوء مرئي اللي هو ممكن يكون أخضر،
+
+399
+00:30:49,150 --> 00:30:52,390
+ممكن يكون أزرق، ممكن يكون أصفر، حسب نوع المادة
+
+400
+00:30:52,390 --> 00:30:56,550
+اللي إحنا أضفناها على اللي هو الـ Antibody
+
+401
+00:30:57,600 --> 00:31:01,160
+وجدنا، كوا هذه التقنية ليست فقط تستخدم للفيروسات
+
+402
+00:31:01,160 --> 00:31:06,560
+وإنما تستخدم لكثير من البكتيريا، نعمل staining with
+
+403
+00:31:06,560 --> 00:31:11,060
+specific fluorescent labeled antibody للليجونيلا
+
+404
+00:31:11,060 --> 00:31:16,760
+للمايكوبكتيريا، لكثير من أنواع البكتيريا، الراديو
+
+405
+00:31:16,760 --> 00:31:20,820
+نفس الفكرة، لكن بدل ما إحنا بنطلع تحت الـ microscope
+
+406
+00:31:20,820 --> 00:31:23,960
+بنجيس على جهاز بنجيس الـ radio activity
+
+407
+00:31:26,360 --> 00:31:29,020
+الإنزايم linked immunosorbent assay، أنا أعتقد أنكم
+
+408
+00:31:29,020 --> 00:31:34,800
+انشرح لكم عشرات المرات، لكن أيضًا يعني، لأ بقصد إنه
+
+409
+00:31:34,800 --> 00:31:39,120
+نمر عليه مرور سريع للتذكير، الـ الـ الـ الـ الـ الـ الـ
+
+410
+00:31:39,120 --> 00:31:39,140
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+411
+00:31:39,140 --> 00:31:42,240
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+412
+00:31:42,240 --> 00:31:43,140
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+413
+00:31:43,140 --> 00:31:52,400
+الـ الـ الـ الـ الـ الـ الـ الـ الـ 
+
+414
+00:31:52,400 --> 00:31:54,690
+الـ الـ الـ الـ الـ الـ الـ الـ Specific كلمة مرة
+
+415
+00:31:54,690 --> 00:32:05,330
+Specific Antibody، الآن بنبحث عن الفيروس، إحنا هندهش
+
+416
+00:32:05,330 --> 00:32:10,310
+الآن الفيروس فيه عينة برضه، شعقش يعني حطيت عينة
+
+417
+00:32:10,310 --> 00:32:13,230
+وارتبط الفيروس بالـ Antibody، مش شايف ولا حاجة أنا
+
+418
+00:32:13,230 --> 00:32:17,210
+حد الآن، مش قادر أشوف ولا حاجة، إيش عملت؟ ضفت
+
+419
+00:32:17,210 --> 00:32:22,130
+Antibody ثاني خذوا بالكم، هذا الـ Antibody هو نفس
+
+420
+00:32:22,130 --> 00:32:27,830
+الـ Antibody اللي تحت هنا، لكن مضاعف إله Enzyme،
+
+421
+00:32:27,830 --> 00:32:34,450
+الآن الـ Antibody اللي إله إله Enzyme، كون الفيروس
+
+422
+00:32:34,450 --> 00:32:38,870
+كتلة كبيرة بالمقارنة مع الـ Antibody، فيه أكثر من
+
+423
+00:32:38,870 --> 00:32:42,450
+مكان ارتباط، فهيرتبط و يسوي sandwich، يعني الفيروس
+
+424
+00:32:42,450 --> 00:32:47,390
+الآن بين two antibodies، برضه لحتى اللي أنا مش
+
+425
+00:32:47,390 --> 00:32:52,260
+شايف ولا حاجة، بنغسل الـ wells عشان أي حاجة مش مرتبطة
+
+426
+00:32:52,260 --> 00:33:04,720
+تروح، وبنضيف عليها الـ substrate بس، ولاش كمان و
+
+427
+00:33:04,720 --> 00:33:13,560
+chromogen، الـ chromogen هو المادة اللي ترتبط بنواتج
+
+428
+00:33:13,560 --> 00:33:17,460
+تكسر الـ substrate، بنواتج تكسر الـ substrate وتعطي
+
+429
+00:33:17,460 --> 00:33:23,580
+لون، المحصرة يابطلع في لون، يابطلعش لون، تعالوا
+
+430
+00:33:23,580 --> 00:33:30,780
+نقول طلع لون، color، استمعوا
+
+431
+00:33:30,780 --> 00:33:34,420
+جيدا لما سأقول من فوق لتحت، إحنا بدأنا من تحت
+
+432
+00:33:34,420 --> 00:33:38,580
+لفوق، لأ نقول إن في color، positive اه positive الـ
+
+433
+00:33:38,580 --> 00:33:41,450
+color positive، لكن كيف صار positive؟ بنقول مدام
+
+434
+00:33:41,450 --> 00:33:44,450
+فيه color يبقى فيه substrate اتكسر، فيه substrate
+
+435
+00:33:44,450 --> 00:33:47,750
+اتكسر، مدام فيه substrate اتكسر يبقى فيه إنزيم
+
+436
+00:33:47,750 --> 00:33:50,530
+موجود، مدام الإنزيم موجود يبقى الـ antibody تبع
+
+437
+00:33:50,530 --> 00:33:53,050
+الإنزيم موجود، ليش الـ antibody موجود؟ ما إحنا
+
+438
+00:33:53,050 --> 00:33:56,370
+غسلناها؟ لإن الـ .. لإن الـ antigen اللي هو الـ virus
+
+439
+00:33:56,370 --> 00:34:01,640
+موجود، وإحنا بيقولوا على مين قاعد الآن؟ يبقى هو موجود
+
+440
+00:34:01,640 --> 00:34:05,980
+وصل الصورة، no color، مافيش color، يبقى مافيش
+
+441
+00:34:05,980 --> 00:34:09,800
+substrate كسر، ليش مافيش substrate كسر؟ لأن مافيش
+
+442
+00:34:09,800 --> 00:34:12,640
+إنزيم، طب وين الإنزيم اللي أنا كنت حاط قبل شوية؟
+
+443
+00:34:12,640 --> 00:34:17,120
+راح مع الغسيل، ليش راح مع الغسيل؟ لأنه مرتبطش، ليش
+
+444
+00:34:17,120 --> 00:34:20,500
+مرتبطش؟ لأن مافيش فيروس، كمان مافيش فيروس يعني
+
+445
+00:34:20,500 --> 00:34:24,030
+negative، وهناك كان فيه فيروس يعني positive، فالإليزا
+
+446
+00:34:24,030 --> 00:34:28,690
+الـ principle تبعها صحيح وبسيط، وهي دخلت في معظم
+
+447
+00:34:28,690 --> 00:34:33,890
+المجالات في التشخيص، ولحد الآن ما زالت يعني صامدة
+
+448
+00:34:33,890 --> 00:34:39,230
+على الرغم من إنه في تقنيات جديدة طلت تفوقها دقة و
+
+449
+00:34:39,230 --> 00:34:43,710
+قللت من الـ ELISA، أحد مشاكلها اللي إحنا بنسميها
+
+450
+00:34:43,710 --> 00:34:47,310
+الـ human error factors، إنه لو اثنين اشتغلوها
+
+451
+00:34:47,310 --> 00:34:51,670
+دقتهم في الـ dilution وفي الغسيل كده مختلفة
+
+452
+00:34:51,670 --> 00:34:54,690
+وبالتالي النتائج ممكن يصير فيها اختلاف، عمومًا في
+
+453
+00:34:54,690 --> 00:34:57,190
+رابط في المحاضرة، راح نزلكم بعد قليل إن شاء الله
+
+454
+00:34:57,190 --> 00:35:01,430
+على الصفحة، في رابط أيضًا لـ animation جيدة توضح
+
+455
+00:35:01,430 --> 00:35:07,210
+اللي هو الـ ELISA، immune electron microscopy، طبعًا
+
+456
+00:35:07,210 --> 00:35:10,770
+الـ Electron Microscope من فوائده إن إحنا ممكن نشوف
+
+457
+00:35:10,770 --> 00:35:14,950
+الـ virus itself في كل الـ reactions اللي شفناه
+
+458
+00:35:14,950 --> 00:35:19,810
+إحنا في السابق مش شايفين إحنا الـ virus، إحنا شوفنا
+
+459
+00:35:19,810 --> 00:35:25,330
+آثار ارتباطات خصائص، لكن الـ virus itself لم نستطيع
+
+460
+00:35:25,330 --> 00:35:28,590
+رؤيته إلا من خلال مين؟ من خلال الـ electron
+
+461
+00:35:28,590 --> 00:35:33,560
+microscope، الآن الـ electron microscope كمان بتكون
+
+462
+00:35:33,560 --> 00:35:36,620
+تعرفوا إنه الـ focus تبعه، إذا أنا جاي بتطلع في الـ
+
+463
+00:35:36,620 --> 00:35:40,160
+oil immersion وبقول إنه الـ field اللي بشوفه صغير
+
+464
+00:35:40,160 --> 00:35:44,480
+جدا، فعشان أضمن إن أنا أشوف فيروسات تحت الـ
+
+465
+00:35:44,480 --> 00:35:49,480
+electron microscope لابد لنا من إن نجمع هذه
+
+466
+00:35:49,480 --> 00:35:54,130
+الفيروسات في مكان واحد، تمام؟ كيف نجمعها في مكان
+
+467
+00:35:54,130 --> 00:35:57,110
+واحد؟ ممكن نستخدم برضه Antibody، الـ Antibody
+
+468
+00:35:57,110 --> 00:36:01,490
+شنعمل Aggregation، نعمل Centrifugation، ناخد جزء
+
+469
+00:36:01,490 --> 00:36:05,430
+المترسب، ومن ثم نبحث بالـ Electron Microscope،
+
+470
+00:36:05,430 --> 00:36:07,750
+والصورة اللي أمامنا بتوضح إنه بالفعل هتتكلم عن
+
+471
+00:36:07,750 --> 00:36:11,530
+مين؟ عن Aggregates، إيش عن Aggregate؟ تجمعات، هذه
+
+472
+00:36:11,530 --> 00:36:16,210
+التجمعات لم تكن لتكون إلا بفعل مين؟ اللي هو ..
+
+473
+00:36:16,210 --> 00:36:20,210
+هتكسب منها، Immune Electron Microscope
+
+474
+00:36:22,970 --> 00:36:28,910
+في الـ microscopic identification اللي إحنا أول
+
+475
+00:36:28,910 --> 00:36:32,150
+approach حكينا عنه، أو ثاني approach حكينا عنه، قلنا
+
+476
+00:36:32,150 --> 00:36:36,130
+إنه في إن حاجة حكيناها سابقًا اللي هي smear و
+
+477
+00:36:36,130 --> 00:36:39,670
+الـ smear استخدمنا فيه مين؟ الـ light ما
+
+478
+00:36:39,670 --> 00:36:45,290
+استخدمنا الـ electron microscope، وهذا ما أود أن
+
+479
+00:36:45,290 --> 00:36:50,790
+أؤكد عليه، إنه على الرغم من عدم وجود إمكانيات
+
+480
+00:36:50,790 --> 00:36:57,410
+كبيرة لتشخيص الفيروسات في فلسطين، إلا إنه قصور من
+
+481
+00:36:57,410 --> 00:37:01,490
+العاملين في هذا المجال في استغلال موارد يعني، أو
+
+482
+00:37:01,490 --> 00:37:07,290
+فحوصات بسيطة غير ممكنة مثل smear اسمه اللي جونها
+
+483
+00:37:07,290 --> 00:37:10,850
+الممكن من خلاله نشوف الـ multi-nucleated giant cell
+
+484
+00:37:10,850 --> 00:37:13,630
+اللي بيعملها الـ herpes simplex سواء كان الـ type 1
+
+485
+00:37:13,630 --> 00:37:18,170
+ولا الـ type 2، الـ UV ميكروسكوبي هو نفسه الفلوريسنت
+
+486
+00:37:18,170 --> 00:37:21,750
+ميكروسكوبي، ما إحنا قلنا إن الـ UV هو مصدر الإضاءة في
+
+487
+00:37:21,750 --> 00:37:24,810
+الفلوريسنت ميكروسكوبي، نفس الشيء، جامعة طبعًا الـ
+
+488
+00:37:24,810 --> 00:37:27,830
+Electron Microscopy يبقى إحنا فيها إن ها تلت مستويات
+
+489
+00:37:27,830 --> 00:37:32,210
+من الـ Direct Microscopic Identification، الأول
+
+490
+00:37:32,210 --> 00:37:36,070
+Light Microscopy، الثاني Ultraviolet Microscopy
+
+491
+00:37:36,070 --> 00:37:38,250
+والتالت اللي هو Electron Microscopy
+
+492
+00:37:40,910 --> 00:37:43,370
+الصورة اللي أمامنا بتوضح إنها اللي هي الـMulti
+
+493
+00:37:43,370 --> 00:37:46,390
+-Nucleated Giant Cell في الـ Smear، شايفين
+
+494
+00:37:46,390 --> 00:37:50,150
+الخلية اللي متجمعة؟ وكما أن هذه كانت وسيلة من
+
+495
+00:37:50,150 --> 00:37:54,230
+وسائل بعض أنواع من الفيروسات أن تهرب من جهاز
+
+496
+00:37:54,230 --> 00:37:59,210
+المناعة بأنها تقوم بعمل عدوى من خلية إلى خلية
+
+497
+00:37:59,210 --> 00:38:03,450
+دونما الخروج للخارج اللي هو الخلية اللي كانت
+
+498
+00:38:03,450 --> 00:38:07,760
+بالأول، وهذه الصورة هي بالـ UV Microscopy، والصورة
+
+499
+00:38:07,760 --> 00:38:11,980
+الأخيرة الشهير Ebola virus اللي عامل زي الدودة هذا
+
+500
+00:38:11,980 --> 00:38:18,740
+اللي هو نانو فيلو فيروس، Astrologic procedures قدمت 
+
+501
+00:38:18,740 --> 00:38:24,780
+وشرحت الحقيقة الفرق ما بين الـ IgG و IgM وهنا a
+
+502
+00:38:24,780 --> 00:38:28,780
+rise يعني ارتفاع in the title of antibody to the
+
+503
+00:38:28,780 --> 00:38:32,160
+virus can be used to diagnose current infection
+
+504
+00:38:32,160 --> 00:38:37,830
+إذن هو الارتفاع وليس بصفر أو negative وأنا أقول لكم
+
+505
+00:38:37,830 --> 00:38:43,570
+عن خطأ شائع لدينا في التشخيص هنا هو أن الـ IgG يمكن
+
+506
+00:38:43,570 --> 00:38:48,650
+أن يكون أداء لتشخيص الأمراض، هذا خطأ شائع، الـ IgG 
+
+507
+00:38:48,650 --> 00:38:52,790
+فقط في حالة أن يكون في حالة rise، rise يعني ارتفاع
+
+508
+00:38:52,790 --> 00:38:56,690
+في الـ Seroconversion هو المصطلح اللي كنتوا
+
+509
+00:38:56,690 --> 00:39:00,250
+عارفينه، Seroconversion is the term used to
+
+510
+00:39:00,250 --> 00:39:04,090
+describe the finding of an antibody to a virus or
+
+511
+00:39:04,090 --> 00:39:06,170
+any microbe، واحنا في الحالة دلوقتي نتكلم عن
+
+512
+00:39:06,170 --> 00:39:10,110
+الفيرولوجيا، in a patient serum who previously had
+
+513
+00:39:10,110 --> 00:39:15,990
+no antibody، يعني تحول من negative إلى positive،
+
+514
+00:39:15,990 --> 00:39:18,450
+ومن هنا المصطلح اسمه Seroconversion
+
+515
+00:39:21,790 --> 00:39:28,270
+بطريقة أخرى تعرف مين؟ الـ patient serum has
+
+516
+00:39:28,270 --> 00:39:31,450
+converted from antibody negative to antibody
+
+517
+00:39:31,450 --> 00:39:35,710
+positive، إذا كان بالفعل ما عنده antibodies، و
+
+518
+00:39:35,710 --> 00:39:38,670
+الآن صار عنده antibody، هذا المصطلح سميناه sero
+
+519
+00:39:38,670 --> 00:39:39,410
+conversion
+
+520
+00:39:44,890 --> 00:39:48,250
+فاكرين التاريخ اللي حكيناه هناك؟ عشر ولا أربعة عشر؟
+
+521
+00:39:48,250 --> 00:39:51,150
+لا أربعة عشر يوم .. إيش العشر وأربعة عشر يوم هدول؟ هي
+
+522
+00:39:51,150 --> 00:39:56,070
+الفترة ما بين الفحص الأول و الفحص اللي هو الثاني
+
+523
+00:39:56,070 --> 00:40:01,750
+بس في رقم هنا .. بتعرفوا أنتم متى الإنسان بيلجأ
+
+524
+00:40:01,750 --> 00:40:04,950
+للفحص؟ لما بتكون الأعراض طبعًا موجودة ولا لا؟
+
+525
+00:40:04,950 --> 00:40:10,020
+acute phase .. بنسميها الطور الحاد من الأعراض 
+
+526
+00:40:10,020 --> 00:40:13,380
+مصطلح ثاني اسمه convalescent phase، إيش الـ
+
+527
+00:40:13,380 --> 00:40:17,400
+convalescent phase؟ اللي هو فترة النقاهة، إيش هي
+
+528
+00:40:17,400 --> 00:40:18,440
+فترة النقاهة؟
+
+529
+00:40:23,250 --> 00:40:27,530
+هي .. هي فترة يلزم من مين؟ من الـ recovery period،
+
+530
+00:40:27,530 --> 00:40:30,570
+convalescent period هي لزم من الـ recovery period،
+
+531
+00:40:30,570 --> 00:40:35,710
+بتبدأ الأعراض تخف و المريض بقى بيتحسن، إذا السؤال
+
+532
+00:40:35,710 --> 00:40:40,170
+اللي بطرح نفسه ما هي القيمة التي سنحصل عليها
+
+533
+00:40:40,170 --> 00:40:46,050
+عندما نشخص مرض بعد الانتهاء منه أساسًا، انتهاءً أنا
+
+534
+00:40:46,050 --> 00:40:51,190
+بتكلم عن اليوم أنا كنت في حالة حادة من المرض أنا
+
+535
+00:40:51,190 --> 00:40:56,070
+بحتاج حاجة إلى التشخيص صح ولا لأ؟ ما الفائدة أنهم
+
+536
+00:40:56,070 --> 00:41:00,350
+يقولوا كان عندك بعد عشر أيام أو أربعة عشر يوم كان عندك
+
+537
+00:41:00,350 --> 00:41:06,730
+هذا المرض هذا الكلام بالضبط لا مش بس هيك بيفيدنا
+
+538
+00:41:06,730 --> 00:41:10,070
+بأن أول حاجة أكد الـ diagnosis confirmed
+
+539
+00:41:16,730 --> 00:41:24,290
+أنتم درستوا Epidemiology ولا لسه؟ الـ
+
+540
+00:41:24,290 --> 00:41:30,350
+Epidemiology مهم جدا جدا جدا في تحديد مستقبل الصحة
+
+541
+00:41:30,350 --> 00:41:34,150
+العامة والطب بشكل عام في أي بلد من البلدان
+
+542
+00:41:36,440 --> 00:41:40,740
+أمتلك معلومات عن الأمراض ونسبتها .. نسبة حدوثها
+
+543
+00:41:40,740 --> 00:41:45,700
+في مجتمعاتنا لن أستطيع أن أخطط في المستقبل لكيفية
+
+544
+00:41:45,700 --> 00:41:50,260
+أتمنع هذه الأمراض صحيح أنه لن يعود بالفائدة على
+
+545
+00:41:50,260 --> 00:41:54,120
+مين؟ على المريض نفسه أو على الشخص نفسه لكن هناك
+
+546
+00:41:54,120 --> 00:41:58,840
+فائدة كمان مرة للمجتمع بأن احنا بنسجل حالات اللي
+
+547
+00:41:58,840 --> 00:42:03,360
+هي الـ confirmed epidemiology طبعًا احنا قلنا أن الـ
+
+548
+00:42:03,360 --> 00:42:07,680
+.. ال .. ال .. في فرق واضح بين الـ IgG و IgM في هذه
+
+549
+00:42:07,680 --> 00:42:12,300
+الحالة المرة القادمة إن شاء الله بنكمل الجزئين
+
+550
+00:42:12,300 --> 00:42:17,200
+المتعلقة بال .. ال .. الـ viral antigens و الـ viral
+
+551
+00:42:17,200 --> 00:42:18,460
+nucleic acid بإذن الله
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2674a3a0f14a71b028799ae4747831979a6a000c
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_postprocess.srt
@@ -0,0 +1,1260 @@
+1
+00:00:21,060 --> 00:00:23,300
+بسم الله الرحمن الرحيم احنا المحاضرة الماضية بدأنا
+
+2
+00:00:23,300 --> 00:00:27,620
+في ال viral vaccine وما انتهينا منه فقبل ما نكمل
+
+3
+00:00:27,620 --> 00:00:30,820
+ان شاء الله هنمر مرور سريع على المعلومات اللي مرنا
+
+4
+00:00:30,820 --> 00:00:35,060
+عليها بشرح المرة الماضيةواتحدثنا على ان ال viral
+
+5
+00:00:35,060 --> 00:00:39,620
+vaccines كتير مهمة اللي بسبب انه ليس لدينا
+
+6
+00:00:39,620 --> 00:00:43,460
+antivirals بكفاءة ال antibiotics وبالتالي احنا
+
+7
+00:00:43,460 --> 00:00:47,860
+محتاجين نمنع جلنا اللي هو ال disease اتجسسنا
+
+8
+00:00:47,860 --> 00:00:53,140
+الموضوع المتعلق بمنع ضد الفيروسات او بالتطعيم او
+
+9
+00:00:53,140 --> 00:00:56,690
+بالتحصين للفيروساتإلى active immunity و passive
+
+10
+00:00:56,690 --> 00:01:00,190
+immunity واتكلمنا عن اللي هو ال vaccines اللي هي
+
+11
+00:01:00,190 --> 00:01:05,110
+بتعمل induction active immunity و ال vaccines
+
+12
+00:01:07,210 --> 00:01:11,230
+قسمناهم لقسمين رئيسيا ياما live attenuated أو
+
+13
+00:01:11,230 --> 00:01:14,850
+killed وجيبنا كمان نوع تالت اللي هو سمناها subunit
+
+14
+00:01:14,850 --> 00:01:18,410
+vaccine وكنا هذا بينطبق عليه ما ينطبق على ال
+
+15
+00:01:18,410 --> 00:01:22,690
+killed vaccine وحاولنا نعمل مقارنة بين التنين
+
+16
+00:01:22,690 --> 00:01:25,510
+والحقيقة ان جدول هذا كان هو الأهم على الإطلاق في
+
+17
+00:01:25,510 --> 00:01:30,330
+كل المحاضرة لإنه بعطينا فكرة عن مزالة وعيوب كل من
+
+18
+00:01:30,330 --> 00:01:32,890
+ال killed و ال live vaccine والسؤال اللي انا
+
+19
+00:01:32,890 --> 00:01:36,350
+اتسألته وقلتلكوا ماتجهوش عليه بالذكاءهو سؤال مين
+
+20
+00:01:36,350 --> 00:01:40,190
+أحسن؟ قلنا لكم أنه قد لا نستطيع الحصول على أحد من
+
+21
+00:01:40,190 --> 00:01:43,810
+الأثنين، وبالتالي الأفضل هو الذي يستخدم ال
+
+22
+00:01:43,810 --> 00:01:49,330
+situation ويقوم على حل هذه المسألة، لكن باختصار ال
+
+23
+00:01:49,330 --> 00:01:53,870
+effectiveness تباعالـ Live Vaccine كان أحسن بكتير
+
+24
+00:01:53,870 --> 00:01:58,470
+من الـ Killed Vaccine لأنه بيحفظ مش فقط الـ IgG
+
+25
+00:01:58,470 --> 00:02:02,390
+وإنما كمان الـ IgA بالإضافة إلى الـ Cell Mediated
+
+26
+00:02:02,390 --> 00:02:06,470
+Immunity وهذا أمر جيد جدا في الـ Viral Infection
+
+27
+00:02:08,080 --> 00:02:14,140
+اتكلمنا عن بعض الأيوب المتعلقة بالـ live vaccine
+
+28
+00:02:14,140 --> 00:02:18,340
+أو بالأحرى مخاوف، و ذكرنا ثلاث مخاوف، جونا الأول
+
+29
+00:02:18,340 --> 00:02:22,780
+أنه يصبح هناك reversion من الـ attenuated إلى الـ
+
+30
+00:02:22,780 --> 00:02:26,440
+violent، رقم اتنين يصبح له shedding في البيئة، إن
+
+31
+00:02:26,440 --> 00:02:30,500
+الإنسان اللي أخذ تطييب ينتج هذا الفيروس إلى الـ
+
+32
+00:02:30,500 --> 00:02:33,900
+environment ويبدأ ينقل المرض للآخرين،و أقم تلاتة
+
+33
+00:02:33,900 --> 00:02:38,740
+اللي هو إنه يكون فيه contamination لل .. للفيروس ب
+
+34
+00:02:38,740 --> 00:02:42,860
+second virus هذه ال .. أو النقطة الثالثة كنا
+
+35
+00:02:42,860 --> 00:02:46,700
+بيشترك فيها كل من ال live و ال .. و ال .. و ال
+
+36
+00:02:46,700 --> 00:02:49,220
+killed لكن الخطر الأكبر في ال live أنه إحنا
+
+37
+00:02:49,220 --> 00:02:53,760
+بنعرضوش لأي معالجة لقتل الفيروس و لتالي ال
+
+38
+00:02:53,760 --> 00:03:00,000
+contaminant هيكون live تمام برضه حقيقيذكرنا إنه في
+
+39
+00:03:00,000 --> 00:03:05,420
+بعض ال .. في مخاوف أخرى من وجود حساسية خاصة ل ..
+
+40
+00:03:05,420 --> 00:03:09,340
+لدى الأشخاص اللي حاسسين لأحد مشتقات البيض لإنه في
+
+41
+00:03:09,340 --> 00:03:12,860
+بعض ال vaccines تنتج في ال chick embryo أو الجنين
+
+42
+00:03:12,860 --> 00:03:14,420
+تبع الدجاجة
+
+43
+00:03:18,330 --> 00:03:22,110
+اتعلننا مصطلحين الـ pre exposure و ال post
+
+44
+00:03:22,110 --> 00:03:25,970
+exposure و قلنا ان ال pre exposure هو الذي يعني
+
+45
+00:03:25,970 --> 00:03:30,270
+ادارج ان احنا بناخد الفاكسين قبل ما نتعرض للفيروس
+
+46
+00:03:30,270 --> 00:03:35,630
+لكن في بعض الأحيان انسان عده كلب مسهور تمام هذا
+
+47
+00:03:35,630 --> 00:03:39,010
+تعرض للفيروس already تعرضفهل يمكن أن نعطيه فاكسين
+
+48
+00:03:39,010 --> 00:03:42,070
+بعد ما اتعرض هذا اسمه post exposure؟ واحد تعرض
+
+49
+00:03:42,070 --> 00:03:45,810
+لغزة إبرة Hepatitis تمام؟ هل نعطيه فاكسين بعد ما
+
+50
+00:03:45,810 --> 00:03:48,630
+اتعرض ولا ما نعطيهوش؟ وهل بينفع الكلام هذا في كل
+
+51
+00:03:48,630 --> 00:03:52,610
+الحالات؟ ولا فقط في حالات معينة؟ هذا ذكرنا احنا
+
+52
+00:03:52,610 --> 00:03:56,050
+مثلين فقط اللي هو ال rapist وال hepatitis B الكلام
+
+53
+00:03:56,050 --> 00:04:01,360
+هو ايضا عن مستقبل الفاكسين واتحدثنا عن البعضال ..
+
+54
+00:04:01,360 --> 00:04:04,320
+ال .. ال .. خدنا نقول الأفاق التي يعمل عليها
+
+55
+00:04:04,320 --> 00:04:08,500
+العلماء حاليا في موضوع ال vaccine مثل إيش؟ مثل إنه
+
+56
+00:04:08,500 --> 00:04:14,700
+أنا أستخدم DNA vaccine أو أستخدم subunit vaccine
+
+57
+00:04:14,700 --> 00:04:19,160
+أو أستخدم viral vaccine يعني vaccine عبارة عن
+
+58
+00:04:19,160 --> 00:04:24,920
+فيروس مليان جينات لفيروسات و مايكروبات أخرىبنحقن
+
+59
+00:04:24,920 --> 00:04:28,200
+المريض ب one virus لكن واقعال اول حد بنطعمه ضد
+
+60
+00:04:28,200 --> 00:04:33,280
+مجموعة كبيرة من الفيروسات او الميكروبات الاخرى DNA
+
+61
+00:04:33,280 --> 00:04:38,370
+VaccineVirus to vaccinate against other viruses
+
+62
+00:04:38,370 --> 00:04:41,930
+وشفنا انه بدلا كل smallpox او ال vaccine هي virus
+
+63
+00:04:41,930 --> 00:04:47,630
+بالاخرى هو المرشح لهذا الموضوع ايضا تحدثنا عن بعض
+
+64
+00:04:47,630 --> 00:04:51,690
+ال vaccines الفيروسية اللي بناخدها بشكل common
+
+65
+00:04:51,690 --> 00:04:55,850
+بشكل روتيني وبعض ال vaccines اللي فقط بناخدها
+
+66
+00:04:55,850 --> 00:05:00,530
+during special situations يعني أوضاع خاصة مثل
+
+67
+00:05:00,530 --> 00:05:06,670
+السفر بين مناطق موبوعة ممكن خلال حروب الاخرأيضا
+
+68
+00:05:06,670 --> 00:05:10,370
+تحدثنا عن ال .. ال vaccines اللي بتوعطل الأطفال أو
+
+69
+00:05:10,370 --> 00:05:14,050
+يوصل إن الأطفال ياخدوها من سن يوم إلى ست سنوات
+
+70
+00:05:14,050 --> 00:05:17,130
+سببها كانت bacterial vaccine أو viral vaccine
+
+71
+00:05:17,130 --> 00:05:20,850
+وتوقفنا عند هذه اللوحة اللي هي ال passive immunity
+
+72
+00:05:20,850 --> 00:05:25,730
+وال passive immunityسميت passive لأنه مافيش جهد
+
+73
+00:05:25,730 --> 00:05:30,310
+بيبذل من قبل العائل لإنتاج أجسام مضادة احنا
+
+74
+00:05:30,310 --> 00:05:35,470
+بنجهزله أجسام مضادة خارج جسمه و بنعطيها جهزة كيف
+
+75
+00:05:35,470 --> 00:05:40,150
+بنجهزله إيها؟ إما بتكون من مصدر حيواني أو من مصدر
+
+76
+00:05:40,150 --> 00:05:49,060
+آدمي بمعنى تتذكروا ال rabid؟people مش بنعطيهم احنا
+
+77
+00:05:49,060 --> 00:05:52,300
+vaccine لو بنعطيهم vaccine ايش بيصير في دم هم دولة
+
+78
+00:05:52,300 --> 00:05:56,280
+اجسام مضادة بنجمعلنا عشر اشخاص من اللي انصابوا بال
+
+79
+00:05:56,280 --> 00:05:59,460
+rabies قبلك او اتعرضوا لل rabies واخدوا vaccine
+
+80
+00:05:59,460 --> 00:06:03,520
+الان في اجسامهم اجسام مضادة جاهزة بناخد منهم عينات
+
+81
+00:06:03,520 --> 00:06:07,380
+دم وبنفصل ال antibodies سبعة ال rabies وبنعطيها
+
+82
+00:06:07,380 --> 00:06:14,100
+لمريض اخر اذا ممكن نحضرها في انسان وفي بعضالـ
+
+83
+00:06:14,100 --> 00:06:17,160
+Immunoglobulin ممكن تحضر فيه أيضا في حيوانات لكن
+
+84
+00:06:17,160 --> 00:06:22,960
+يبقى الخشية لما يكون المصدر للاجسام المضاد من
+
+85
+00:06:22,960 --> 00:06:26,720
+حيواني ان يكون فيه hypersensitivity يعني نوع من
+
+86
+00:06:26,720 --> 00:06:31,940
+ايه؟ من الحساسية ضد هذه الأجسام في مصطلح قلنا عنه
+
+87
+00:06:31,940 --> 00:06:35,180
+passive active immunity يعني قلنا passive active
+
+88
+00:06:35,180 --> 00:06:37,080
+immunity vaccine و passive immunity بنعطي
+
+89
+00:06:37,080 --> 00:06:40,640
+immunoglobulin طب لما يكون المصطلح passive active
+
+90
+00:06:40,640 --> 00:06:45,720
+immunity بدنا نعطي اتنين مع بعضماذا نعطيه مع بعض؟
+
+91
+00:06:45,720 --> 00:06:48,440
+نعطيه الـ Immunoglobulin اللي هو الـ Passive و
+
+92
+00:06:48,440 --> 00:06:53,400
+نعطيه الـ Vaccine و هذا الكلام ينطبق تماما على نفس
+
+93
+00:06:53,400 --> 00:06:57,800
+الحالتين اللي أنا ذكرتهم للـ Post Exposure منهم
+
+94
+00:06:57,800 --> 00:07:03,140
+الـ Rares و الـ Hepatitis تعالى نطلع على ال
+
+95
+00:07:03,140 --> 00:07:09,120
+Immunoglobulin اللي هي جنة تدخل ضمن إطار ال
+
+96
+00:07:09,120 --> 00:07:14,310
+Vaccination اللي هي الـ RIG و الـ RIG اختصارRapes
+
+97
+00:07:14,310 --> 00:07:19,250
+immunoglobulin تستخدم
+
+98
+00:07:19,250 --> 00:07:24,550
+في ال prevention للرايبز في الأشخاص الذين تعرضوا
+
+99
+00:07:24,550 --> 00:07:29,390
+للفيروس كيف تعرضوا للفيروس؟ إما يكون عضة من حيوان
+
+100
+00:07:29,390 --> 00:07:33,650
+رابد، رابد يعني مصاب بي اللي هو ال rapes أو ممكن
+
+101
+00:07:33,650 --> 00:07:38,490
+تعرضة saliva من خفافيش تمام؟ الخفافيش ممكن تنقل ال
+
+102
+00:07:38,490 --> 00:07:43,950
+rapes عبر اللي هو ال salivaبنطلع الآن على الوسيلة
+
+103
+00:07:43,950 --> 00:07:48,090
+أو الكيفية اللى بتم إعطاء فيها الـ Reg للأشخاص
+
+104
+00:07:48,750 --> 00:07:54,430
+Inject as much rig as possible into the tissue at
+
+105
+00:07:54,430 --> 00:07:58,430
+the bite site اذا كان في عضة فاحقن قدر بيتها
+
+106
+00:07:58,430 --> 00:08:02,270
+استطيع من ايه من ال immunoglobulin ليش؟ بقول ان ال
+
+107
+00:08:02,270 --> 00:08:05,630
+immunoglobulin ترتبط بالفيروس و بتعمل
+
+108
+00:08:05,630 --> 00:08:08,930
+neutralization للفيروس فالفيروس في هذا الحالة لن
+
+109
+00:08:08,930 --> 00:08:12,750
+يستطيع الدخول الى الخلايا و لن يتكاثر فانت بتقليلي
+
+110
+00:08:12,750 --> 00:08:17,150
+احتمالية ان الفيروس ايه يتكاثر في هذه المنطقة
+
+111
+00:08:19,430 --> 00:08:23,770
+فالآن هنحقنه بيحقن as much as possible في منطقة
+
+112
+00:08:23,770 --> 00:08:28,850
+العضة والباقي بيحقنه intramuscularly ليش
+
+113
+00:08:28,850 --> 00:08:32,830
+intramuscularly؟ بدنا ييروح على الدم، ليش بدنا
+
+114
+00:08:32,830 --> 00:08:37,750
+ييروح على الدم؟ عشان إذا فيروس escaped من المنطقة
+
+115
+00:08:37,750 --> 00:08:41,630
+اللي هي منطقة العضة، يلاقي هذا اللي هو ال antibody
+
+116
+00:08:41,630 --> 00:08:45,980
+لما له أيضا neutralizationمن وين بنجيب ال
+
+117
+00:08:45,980 --> 00:08:51,520
+antibody؟ من متطوعين
+
+118
+00:08:51,520 --> 00:08:56,700
+بنادمين متطوعين بنعملهم hyper immunization نعطيهم
+
+119
+00:08:56,700 --> 00:09:05,120
+جرعة كبيرة من ال vaccine فبصير لديهم كمية كبيرة من
+
+120
+00:09:05,120 --> 00:09:05,880
+ال antibody
+
+121
+00:09:09,130 --> 00:09:12,310
+Rig is obtained from human to avoid
+
+122
+00:09:12,310 --> 00:09:15,610
+hypersensitivity reactions وهذا الكلام قدّمناله
+
+123
+00:09:15,610 --> 00:09:18,910
+وقلنا لكوا إنه لو كان المصدر الحيواني الخشية
+
+124
+00:09:18,910 --> 00:09:24,750
+موجودة من أن يحدث هناك تثاعر حساسية type 1
+
+125
+00:09:24,750 --> 00:09:28,950
+hypersensitivity أو anaphylactic shock
+
+126
+00:09:31,860 --> 00:09:34,580
+In addition to reg, the vaccine containing killed
+
+127
+00:09:34,580 --> 00:09:39,080
+virus made in human-deployed cells should be given
+
+128
+00:09:39,080 --> 00:09:44,760
+يبقى هنا نموذج رائع على active passive immunity
+
+129
+00:09:44,760 --> 00:09:48,240
+انا استخدمت immunoglobulin و في نفس الولد يقعد
+
+130
+00:09:48,240 --> 00:09:55,060
+بستخدم vaccine ليش بينجح هذا الكلام في ال rabies؟
+
+131
+00:09:55,090 --> 00:09:58,370
+ونال ريبز و الهيباطيتس في إيه اللي هم ميزة؟ إن
+
+132
+00:09:58,370 --> 00:10:02,770
+الاتنين كلاهما اندو incubation period طويلة
+
+133
+00:10:02,770 --> 00:10:06,890
+وبالتالي طول ال incubation period هذا بيسهل على
+
+134
+00:10:06,890 --> 00:10:10,810
+جسمنا أنه أبعد فرصة للجسم تبعنا إنه يكون أجسام
+
+135
+00:10:10,810 --> 00:10:15,530
+مضادة حتى بعد اللي هو ال exposure بينما هذا الكلام
+
+136
+00:10:15,530 --> 00:10:20,070
+غير صحيح في كثير من الفيروسات يعني لو افترضنا
+
+137
+00:10:20,070 --> 00:10:24,210
+نتعرضنا ل ال missiles تمام؟ مينفعش أعطي فاكسين بعد
+
+138
+00:10:24,210 --> 00:10:30,180
+التعرضخلاص الآن ال .. ال .. الفيروس already
+
+139
+00:10:30,180 --> 00:10:32,680
+established .. already established لكن في الـ
+
+140
+00:10:32,680 --> 00:10:36,140
+hepatitis والرابس فيه نوعا ما long incubation
+
+141
+00:10:36,140 --> 00:10:39,720
+period تسمح للجسم انه يكون antibody لو احنا
+
+142
+00:10:39,720 --> 00:10:43,620
+اعطيناه الفاكسينة الفاكسينة وانا محضر .. محضر على
+
+143
+00:10:43,620 --> 00:10:47,600
+human deployed cells يعني cell culture آدمية أيضا
+
+144
+00:10:47,600 --> 00:10:53,220
+حتى نقلل من إمكانية ان يكون فيه أيضا حساسينRig
+
+145
+00:10:53,220 --> 00:10:55,540
+اللي هو قلنا rape is immunoglobulin and the
+
+146
+00:10:55,540 --> 00:10:58,400
+vaccine should be given a different size إذا نعضّى
+
+147
+00:10:58,400 --> 00:11:02,020
+في الرجل الشمال، بنعطي ال vaccine في الإيد اليمين،
+
+148
+00:11:02,020 --> 00:11:05,120
+منين يبعد ال vaccine عن مين؟ عن اللي هو ال
+
+149
+00:11:05,120 --> 00:11:10,290
+immunoglobulinبدناش ال immunoglobulin يتفاعل مع ال
+
+150
+00:11:10,290 --> 00:11:12,010
+vaccine أو مع ال neutralization، احنا بدنا ال
+
+151
+00:11:12,010 --> 00:11:15,490
+vaccine يشتغل، بدنا ال vaccine يشتغل، و هذا السيما
+
+152
+00:11:15,490 --> 00:11:18,510
+ما .. ما .. ما ذكرناه على ال rabies ينطبق أيضا على
+
+153
+00:11:18,510 --> 00:11:22,370
+مين؟ على ال hepatitis ب immunoglobulin، this is an
+
+154
+00:11:22,370 --> 00:11:27,750
+example أو an clear example of active passive
+
+155
+00:11:27,750 --> 00:11:31,390
+immunization اللي يقول إنها بتتم غالبا post
+
+156
+00:11:31,390 --> 00:11:36,710
+exposure، post exposureهل ممكن نعطي immunoglobulin
+
+157
+00:11:36,710 --> 00:11:44,950
+pre-exposure؟ الفاكسينة نحن متفقين أن الفاكسينة
+
+158
+00:11:44,950 --> 00:11:47,430
+نعطيها pre-exposure في معظم الحالات إلا في
+
+159
+00:11:47,430 --> 00:11:51,610
+الحالتين اللي ذكرناهم اللي هم ال rapes و ال .. ال
+
+160
+00:11:51,610 --> 00:11:54,650
+.. ال .. hepatitis B هل يمكن أن أعطي
+
+161
+00:11:54,650 --> 00:11:59,800
+immunoglobulin pre-exposure؟من ناحية نظرية، لو أنا
+
+162
+00:11:59,800 --> 00:12:04,320
+بدي أروح على منطقة فيها فيروس منتشر، تمام؟ فيروس
+
+163
+00:12:04,320 --> 00:12:09,040
+منتشر، والآن السفر urgent، وانا مقدرش أخد vaccine
+
+164
+00:12:09,040 --> 00:12:11,620
+عشان أنا سابد دي spike لما أكون أجسام مضادة، ممكن
+
+165
+00:12:11,620 --> 00:12:15,660
+أخد ومش ممكن أخد، ممكن ناخد immunoglobulin for pre
+
+166
+00:12:15,660 --> 00:12:18,600
+exposure لفترات قصيرة، لفترات قصيرة
+
+167
+00:12:21,180 --> 00:12:26,920
+HPIG او Hepatitis B immunoglobulin زي على أغراء
+
+168
+00:12:26,920 --> 00:12:30,260
+نفسه اللي هو ال Rig is used in the prevention of
+
+169
+00:12:30,260 --> 00:12:33,760
+Hepatitis B in people who may have been exposed
+
+170
+00:12:33,760 --> 00:12:38,000
+كلمة who have been و who have may been exposed نفس
+
+171
+00:12:38,000 --> 00:12:42,320
+الفكرة اللي حكيتلكواها الماضية انه غز إبرة من مريض
+
+172
+00:12:42,320 --> 00:12:47,700
+يحتمل ان يكون عنده مثلا Hepatitisزي الـ needle
+
+173
+00:12:47,700 --> 00:12:52,740
+stick أو الـ neonate مولود يديد لأم مثلا معروف إنه
+
+174
+00:12:52,740 --> 00:12:56,720
+عندها hepatitis أو career لل hepatitis B في هذه
+
+175
+00:12:56,720 --> 00:12:59,900
+الحالة ال immunoglobulin بتاع ال hepatitis بيكون
+
+176
+00:12:59,900 --> 00:13:03,540
+مفيد جدا ال preparation contain a high titer of
+
+177
+00:13:03,540 --> 00:13:06,760
+antibody to hepatitis B virus and is obtained from
+
+178
+00:13:06,760 --> 00:13:10,220
+human to avoid hypersensitivity reactions أيضا
+
+179
+00:13:10,220 --> 00:13:14,120
+يُأخذ من مين؟ من البشر حتى نتجنب
+
+180
+00:13:14,120 --> 00:13:19,930
+الhypersensitivityأيضا مثال آخر على active-passive
+
+181
+00:13:19,930 --> 00:13:24,410
+immunization هو هذا المثال الهيباطيتس بي وإننا
+
+182
+00:13:24,410 --> 00:13:28,430
+بنعطي vaccine وبنعطي hepatitis بي immunoglobulin
+
+183
+00:13:28,430 --> 00:13:35,470
+فيه ايضا immunoglobulin للفارسيللازوستر بتعرفوا
+
+184
+00:13:35,470 --> 00:13:37,930
+الفارسيللازوستر صار مشهورة هنا اللي هو ال chicken
+
+185
+00:13:37,930 --> 00:13:43,360
+box و الحزام الناريبرضه بيسموها Vizig أو بيريسيلة
+
+186
+00:13:43,360 --> 00:13:45,100
+زوستر امينو غليبولين بيريسيلة زوستر امينو غليبولين
+
+187
+00:13:45,100 --> 00:13:47,660
+بيريسيلة زوستر امينو غليبولين بيريسيلة زوستر امينو
+
+188
+00:13:47,660 --> 00:13:49,060
+غليبولين بيريسيلة زوستر امينو غليبولين بيريسيلة
+
+189
+00:13:49,060 --> 00:13:53,320
+زوستر امينو غليبولين بيريسيلة زوستر امينو غليبولين
+
+190
+00:13:53,320 --> 00:13:54,840
+بيريسيلة زوستر امينو غليبولين بيريسيلة زوستر امينو
+
+191
+00:13:54,840 --> 00:13:58,620
+غليبولين بيريسيلة زوستر امينو غليبولين بيريسيلة
+
+192
+00:13:58,620 --> 00:14:03,260
+زوستر امينو غليبولين بيريأيضا التحضير اللى اسمه
+
+193
+00:14:03,260 --> 00:14:07,040
+Vizig بيحتوي على high titer of antibody to
+
+194
+00:14:07,040 --> 00:14:10,720
+varicella zoster virus and is obtained from human
+
+195
+00:14:10,720 --> 00:14:13,660
+to avoid hypersensitivity reaction لحظوا الجملة
+
+196
+00:14:13,660 --> 00:14:19,120
+تكررت في الثلاثة أو في الثلاث أمثلة في ال rabies
+
+197
+00:14:19,120 --> 00:14:22,480
+في ال hepatitis B وهي كمان في varicella zoster نفس
+
+198
+00:14:22,480 --> 00:14:26,740
+الجملة لأنه يبدو أنه ال hypersensitivity reaction
+
+199
+00:14:26,740 --> 00:14:32,050
+يعني نسبتها بتكون عالية في الناس وبتاليلتجنب هذا
+
+200
+00:14:32,050 --> 00:14:37,510
+ال reaction بناخد من ال human فينا
+
+201
+00:14:37,510 --> 00:14:42,530
+مثال ال vaccine immunoglobulin ال vaccine اللي كنا
+
+202
+00:14:42,530 --> 00:14:48,530
+نستخدمها لمين؟ لل vaccination لل smallpox في بعض
+
+203
+00:14:48,530 --> 00:14:51,390
+الأطفال اللي كانوا يطعموا ال vaccine اللي كان سينا
+
+204
+00:14:51,390 --> 00:14:57,190
+عندهمخلّينا نقول disease يعني يظهر عليه أعراض ال
+
+205
+00:14:57,190 --> 00:15:02,290
+.. ال .. ال cowpox ال cowpox على هذا الطفل فعشان
+
+206
+00:15:02,290 --> 00:15:08,210
+نخفف عنه تمام كان يعطى immunoglobulin للفاكسين إذا
+
+207
+00:15:08,210 --> 00:15:13,830
+هذا كان يستخدم .. الآن لا يستخدم ليش لا يستخدم؟
+
+208
+00:15:13,830 --> 00:15:17,570
+لأن أصلا الفاكسين توقف الفاكسين توقف وماذا توقف
+
+209
+00:15:17,570 --> 00:15:23,580
+الفاكسين قلنالكوالما صارت الحالات تبع ال .. ال ..
+
+210
+00:15:23,580 --> 00:15:25,660
+ال vaccination إنها تجعل ال vaccination أعلى من
+
+211
+00:15:25,660 --> 00:15:28,580
+الحالات اللي هي acquired .. acquired by natural
+
+212
+00:15:28,580 --> 00:15:34,600
+route رقم خمسة immunoglobulin بشكل عامare useful
+
+213
+00:15:34,600 --> 00:15:38,220
+in the prevention or mitigation of hepatitis A or
+
+214
+00:15:38,220 --> 00:15:42,600
+measles in people who may have been exposed to
+
+215
+00:15:42,600 --> 00:15:45,020
+these viruses وكلمة immunoglobulin يبقى
+
+216
+00:15:45,020 --> 00:15:48,900
+immunoglobulin خاصة إما للهيباطيتس A أو خاصة
+
+217
+00:15:48,900 --> 00:15:54,080
+للميسلز يعني مش immunoglobulin بدون مسمة فحنسميها
+
+218
+00:15:54,080 --> 00:15:57,620
+hepatitis A immunoglobulins أو measles
+
+219
+00:15:57,620 --> 00:15:58,800
+immunoglobulins
+
+220
+00:16:01,860 --> 00:16:06,420
+مثلا الهيباطيتس immunoglobulins are commonly used
+
+221
+00:16:06,420 --> 00:16:10,160
+prior to traveling to area .. السؤال .. السؤال
+
+222
+00:16:10,160 --> 00:16:14,400
+السئلتك هي قبل ما ن .. ن .. نصل لهذه اللوحة أنه هل
+
+223
+00:16:14,400 --> 00:16:18,400
+بالإمكان استخدام ال immunoglobulin pre exposure
+
+224
+00:16:18,400 --> 00:16:21,700
+هاي المثال عليها أنه احنا مسافرين على منطقة فيها
+
+225
+00:16:21,700 --> 00:16:24,800
+هيباطيتس ايه ممكن ناخد immunoglobulin بدل ما ناخد
+
+226
+00:16:24,800 --> 00:16:27,820
+اللي هو ال vaccine لأن ال vaccine كمان مرة بده وجه
+
+227
+00:16:27,820 --> 00:16:33,580
+عشان ايه يشترImmunoglobulin contains pooled serum
+
+228
+00:16:33,580 --> 00:16:36,400
+obtained from a large number of human volunteers
+
+229
+00:16:36,400 --> 00:16:42,890
+who are not being hyper immunizedPooling يعني أنا
+
+230
+00:16:42,890 --> 00:16:48,130
+بجيب سيرام X وY وZ وC نصات من مجموعات مختلفة و
+
+231
+00:16:48,130 --> 00:16:52,770
+بحطهم مع بعض فمانهم بركة pooling تمام فدول الناس
+
+232
+00:16:52,770 --> 00:16:56,570
+يعني كلهم immunized مش hyper immunized فعدد ال
+
+233
+00:16:56,570 --> 00:16:59,650
+antibody إيش فيهم أو تركيز ال antibody إيش مالهم
+
+234
+00:16:59,650 --> 00:17:03,250
+بيكون قليل لإنه مش hyper immunized وبالتالي أنا
+
+235
+00:17:03,250 --> 00:17:09,770
+باخدباخد كام كبير من السيرام وبعتمد عملية
+
+236
+00:17:09,770 --> 00:17:13,930
+separation لل immunoglobulin في هذه الحالة
+
+237
+00:17:13,930 --> 00:17:19,010
+effectiveness of immunoglobulin is based on
+
+238
+00:17:19,010 --> 00:17:23,590
+antibody being present in many members of the pool
+
+239
+00:17:23,590 --> 00:17:28,290
+الفعالية معتمدة عالمين على جداش في antibodies
+
+240
+00:17:28,290 --> 00:17:32,950
+موجودة أصلا في الأشخاص اللي أخدنا منهم أو هذه
+
+241
+00:17:32,950 --> 00:17:39,990
+العيناتمصطلح رائع جدا ومفهوم لازم نكون فاهمينه في
+
+242
+00:17:39,990 --> 00:17:45,330
+المناعة اسمه herd immunity و herd باللغة العربية
+
+243
+00:17:45,330 --> 00:17:48,830
+معناها القطيع وبدما انه احنا بنتكلم معاهم بالادمين
+
+244
+00:17:48,830 --> 00:17:54,990
+فيعني مش صح انه انه ان نعيد نفس اللغة و الحقيقة
+
+245
+00:17:54,990 --> 00:17:57,810
+الصحيحة فيها التراب على المصطلح هو انه اصبح اسمها
+
+246
+00:17:57,810 --> 00:18:03,610
+community immunityإنها يتعبر عن المجموعة وبالتالي
+
+247
+00:18:03,610 --> 00:18:07,790
+بدأ المنجول يقطع المنجول يتكلم عن بني أدمينHerd
+
+248
+00:18:07,790 --> 00:18:11,490
+immunity also known as community immunity occurs
+
+249
+00:18:11,490 --> 00:18:14,850
+when sufficiently large percentages of population
+
+250
+00:18:14,850 --> 00:18:19,190
+اللي بيسموها القطية is immunized so that immunized
+
+251
+00:18:19,190 --> 00:18:23,590
+individuals non immunized individual is protected
+
+252
+00:18:23,590 --> 00:18:29,030
+اقولكوا المعنى بلغة بسيطة أو سهلة كام طالب عندى
+
+253
+00:18:29,030 --> 00:18:34,310
+هنا خمسين طالب تمام خمسة واربعين منهم مطعمين وخمسة
+
+254
+00:18:35,010 --> 00:18:39,550
+مش مطعمين هدول الخمسة المش مطعمين اللي حاميهم
+
+255
+00:18:39,550 --> 00:18:45,510
+وجودهم بين خمسة واربعين شخص مطعم يبجأ انتم ك
+
+256
+00:18:45,510 --> 00:18:49,250
+community وفرتوا مناعة لل non immunized
+
+257
+00:18:49,250 --> 00:18:54,090
+individuals كل ما زاد عدد ال immunized تمام كل
+
+258
+00:18:54,090 --> 00:18:57,930
+موفر protection اكتر للاشخاص ال non immunized طبعا
+
+259
+00:18:57,930 --> 00:19:02,910
+هذا الكلام ليس على اطلاقه و لازم نتكلم برضه فيه
+
+260
+00:19:02,910 --> 00:19:04,230
+بشكل واضح
+
+261
+00:19:09,520 --> 00:19:16,760
+لما بنتكلم عن مجتمع نسبة التطايم فيه 90% الجاليش
+
+262
+00:19:16,760 --> 00:19:20,760
+اللي مش مطعمين 10% هل تتوقعوا العشرة في المية
+
+263
+00:19:20,760 --> 00:19:24,500
+يكونوا موزعين توزيع عادل ومنتظم في ال population
+
+264
+00:19:24,500 --> 00:19:30,620
+أعطيكم مثال على أوروبا و أمريكا تمام بلدان للتطور
+
+265
+00:19:30,620 --> 00:19:35,600
+التكنولوجي في منهم جامعات أرقية ودينية بترفض
+
+266
+00:19:35,600 --> 00:19:38,420
+التطايم بترفض التطايم
+
+267
+00:19:41,400 --> 00:19:45,660
+وعايشين بطريقة ان هم منعزلين عن الآخرين بمعنى ان
+
+268
+00:19:45,660 --> 00:19:49,980
+هم لهم their own community يبقى هم مش distributed
+
+269
+00:19:49,980 --> 00:19:54,300
+فاهم عشان نذوبوا بين ال community و احنا نحميهم
+
+270
+00:19:54,300 --> 00:19:58,060
+لهم غالبا اصلا localized يعني اللي لهم مراتب خاصة
+
+271
+00:19:58,060 --> 00:20:02,420
+فلو صار في عندهم disease هينتشر بينهم بشكل كبير و
+
+272
+00:20:02,420 --> 00:20:06,430
+انا في هذا الحالةكلمة community immunity أو herd
+
+273
+00:20:06,430 --> 00:20:10,470
+immunity لن نطبق عليها مثل الصورة لكن المفهوم
+
+274
+00:20:10,470 --> 00:20:15,550
+العام لو كان العشرة في المية موزعين على كل المجتمع
+
+275
+00:20:15,550 --> 00:20:19,610
+بشكل دعنا نقول منتظم أو شبه منتظم بالفعل بتلقوا
+
+276
+00:20:19,610 --> 00:20:24,780
+حماية كيف بتلقوا حماية؟الفيروس أجاني أنا، تمام؟
+
+277
+00:20:24,780 --> 00:20:28,320
+أنا أخدته ولم أمره لأن عندي vaccination، كوني أنا
+
+278
+00:20:28,320 --> 00:20:32,820
+ماأخدته ومامردتش فمانقلتوش لمين للآخرين، فتوقف
+
+279
+00:20:32,820 --> 00:20:36,060
+عندي، فانا صار عندي الفيروس dead end، تمام؟ dead
+
+280
+00:20:36,060 --> 00:20:40,440
+end، فانا حاميت الآخرين من إنهم يصابوالذلك لما
+
+281
+00:20:40,440 --> 00:20:44,900
+نقولكوا لا تمرضوا حتى لا تنقلوا الأمراض للآخرين،
+
+282
+00:20:44,900 --> 00:20:48,680
+تمام؟ لا تمرضوا حتى لا تحصلوا على مضادات حيوية،
+
+283
+00:20:48,680 --> 00:20:52,000
+فتساهموا في نشر ال resistance تبع المضادات
+
+284
+00:20:52,000 --> 00:20:54,940
+الحيوية، وانا مستغرب صحيح ليش مش مشاركين انتوا في
+
+285
+00:20:54,940 --> 00:21:02,010
+حملة اليوم العالمي لرسل اليدين، الأصل انهانسهم
+
+286
+00:21:02,010 --> 00:21:06,950
+سويا في الحملة و احنا فينا مجموعة و الكل مشارك
+
+287
+00:21:06,950 --> 00:21:11,250
+فيها الصحيح و بدأت يعني تاخد منح واسع و trending
+
+288
+00:21:11,250 --> 00:21:13,650
+فبتقولي ارجعوا حضراتكم انكوا تشاركوا في هذه
+
+289
+00:21:13,650 --> 00:21:16,950
+المجموعة و على الأقل تعملوا sharing لبعض المنشورات
+
+290
+00:21:16,950 --> 00:21:22,610
+المتعلقة بالحملة لإن احنا نريد نشر كلمة غسل اليدين
+
+291
+00:21:22,610 --> 00:21:26,630
+ايدينا و مستقبلنا و كلمة ايدينا و مستقبلنا تعرفوا
+
+292
+00:21:26,630 --> 00:21:32,270
+إيها مدلات مهمة ان الطفل هو صغير إذا مرض كتيرغالبا
+
+293
+00:21:32,270 --> 00:21:37,090
+هذا بيفقده جزء من الصحة ممكن يفقده جزء من أيام
+
+294
+00:21:37,090 --> 00:21:42,490
+الدراسية في المدارس ممكن كمان يضعف مناته ممكن يأثر
+
+295
+00:21:42,490 --> 00:21:47,590
+على مستوى الذكاء والعقل وبالتالي بالفعل بإجراءات
+
+296
+00:21:47,590 --> 00:21:52,610
+بسيطة سهلة وميسرة يمكن انه نحافظ على صحة الأطفال
+
+297
+00:21:52,610 --> 00:21:56,410
+ومستقبلهم في هذه الحالة فنحن مطلوب منها كدارسين
+
+298
+00:21:56,410 --> 00:21:59,690
+لهذه العلوم أنه يساهم في نشر هذه الكلمة ان شاء
+
+299
+00:21:59,690 --> 00:22:03,960
+اللهنرجع لمين لل herd immunity او community
+
+300
+00:22:03,960 --> 00:22:09,260
+immunity كما ذكرت هي concept او مفهوم انه كل ما
+
+301
+00:22:09,260 --> 00:22:12,540
+زاد عدد المطعمين في المجتمع كل ما زاد حماية اللي
+
+302
+00:22:12,540 --> 00:22:17,240
+هم الأشخاص غير المطعمين ويمكن الصورة اللي قدامكم
+
+303
+00:22:17,240 --> 00:22:26,180
+هذه بتوضح الفكرة تخيلوا انه عندي في المجتمع هذا كم
+
+304
+00:22:26,180 --> 00:22:31,360
+واحد immunizedno one is immunized لو صار في عندهم
+
+305
+00:22:31,360 --> 00:22:35,680
+disease شوف كم واحد بيصير في عنده infection هاي
+
+306
+00:22:35,680 --> 00:22:38,680
+اتنين صار عندهم infection تمام الكل صار عنده
+
+307
+00:22:38,680 --> 00:22:41,000
+infection فشلا غير مجموعة بسيطة ماصلاش عندهم
+
+308
+00:22:41,000 --> 00:22:45,560
+infection لكن لما بيكونوا الناس immunized معظمهم
+
+309
+00:22:45,560 --> 00:22:49,820
+وفيه non immunized تمام نسبة انتقال المرض اللي هم
+
+310
+00:22:49,820 --> 00:22:54,500
+بتكون قليلة او شبه معدهم اذا the more immunized
+
+311
+00:22:55,210 --> 00:22:59,690
+people are the more protected than immunized
+
+312
+00:22:59,690 --> 00:23:02,970
+people فهذه هي الفكرة العامة لكن كما ذكرت هي مش
+
+313
+00:23:02,970 --> 00:23:07,290
+فكرة absolute بجهة إن كنت انتهينا من الفصل اللي
+
+314
+00:23:07,290 --> 00:23:11,150
+اسمه viral vaccine أرجو أن تكونوا بالفعل استفدته
+
+315
+00:23:11,150 --> 00:23:13,950
+من هذا الفصل نكمل المرة القادمة إن شاء الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..510fcbcc0ffbda925e71846183e24e9ee3fda819
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_raw.json
@@ -0,0 +1 @@
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subunit vaccine وكنا هذا بينطبق عليه ما ينطبق على ال killed vaccine وحاولنا نعمل مقارنة بين التنين والحقيقة ان جدول هذا كان هو الأهم على الإطلاق في كل المحاضرة لإنه بعطينا فكرة عن مزالة وعيوب كل من ال killed و ال live vaccine والسؤال اللي انا اتسألته وقلتلكوا ماتجهوش عليه بالذكاء", "tokens": [4587, 38251, 8315, 16095, 5296, 4587, 38251, 9957, 12602, 19986, 1829, 3794, 25528, 7251, 10943, 995, 1621, 951, 268, 27275, 34051, 4652, 49610, 1829, 3555, 8315, 9122, 2304, 7649, 8717, 45367, 6055, 6027, 2655, 13672, 1829, 31439, 8608, 2304, 8315, 11296, 1422, 409, 270, 7007, 4032, 4117, 8315, 23758, 4724, 9957, 9566, 3555, 4587, 47356, 19446, 7251, 1863, 9566, 3555, 4587, 15844, 2423, 4652, 7007, 4032, 5016, 995, 12610, 8315, 8717, 25957, 1211, 3714, 4587, 9640, 1863, 3660, 49374, 16712, 1863, 9957, 16070, 5016, 38436, 28671, 16472, 10874, 3215, 12610, 23758, 25961, 31439, 16247, 16095, 15844, 33688, 9566, 15040, 4587, 8978, 28242, 9673, 5016, 46958, 25720, 5296, 28814, 1863, 3224, 45030, 9566, 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باختصار ال effectiveness تباع", "tokens": [3224, 2407, 8608, 33604, 6027, 3714, 9957, 5551, 5016, 3794, 1863, 22807, 12174, 1211, 8315, 5296, 24793, 14739, 3224, 12174, 3215, 20193, 8717, 14851, 9566, 40228, 21542, 9381, 12610, 15844, 5551, 24401, 9154, 16247, 12984, 1863, 9957, 12399, 46599, 6027, 2655, 6027, 1829, 16247, 5172, 11242, 1211, 31439, 43527, 7251, 14851, 9778, 40448, 2423, 2590, 4032, 1829, 4587, 20498, 15844, 11331, 1211, 29538, 9673, 3794, 10721, 37977, 12399, 44381, 4724, 47283, 2655, 9381, 9640, 2423, 21208, 6055, 3555, 45761], "avg_logprob": -0.1558593763038516, "compression_ratio": 1.528497409326425, "no_speech_prob": 6.556510925292969e-07, "words": [{"start": 95.07, "end": 95.31, "word": "هو", "probability": 0.869140625}, {"start": 95.31, "end": 95.85, "word": " سؤال", "probability": 0.9807942708333334}, {"start": 95.85, "end": 96.35, "word": " مين", "probability": 0.75}, {"start": 96.35, "end": 97.01, "word": " أحسن؟", "probability": 0.851318359375}, {"start": 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neutralization للفيروس فالفيروس في هذا الحالة لن يستطيع الدخول الى الخلايا و لن يتكاثر فانت بتقليلي احتمالية ان الفيروس ايه يتكاثر في هذه المنطقة", "tokens": [4575, 1020, 382, 709, 8329, 382, 1944, 666, 264, 12404, 412, 264, 7988, 3621, 1975, 15730, 25961, 8978, 6225, 11242, 3660, 6156, 39319, 4587, 1863, 12174, 3215, 2288, 4724, 36081, 11296, 44713, 9566, 40228, 9154, 1975, 1829, 3224, 9154, 2423, 13154, 45841, 12176, 259, 32239, 8592, 22807, 4724, 39648, 16472, 2423, 13154, 45841, 12176, 259, 6055, 43500, 3555, 9566, 20666, 5172, 13546, 41779, 4032, 39894, 25957, 1211, 10598, 2144, 24976, 5172, 13546, 41779, 6156, 6027, 5172, 13546, 41779, 8978, 23758, 21542, 6027, 3660, 5296, 1863, 7251, 14851, 9566, 40228, 32748, 9778, 12610, 2423, 7578, 33962, 15040, 25528, 4032, 5296, 1863, 7251, 2655, 4117, 5718, 104, 2288, 6156, 7649, 2655, 39894, 4587, 20292, 20292, 1975, 33753, 2304, 6027, 10632, 16472, 27188, 13546, 41779, 1975, 1829, 3224, 7251, 2655, 4117, 5718, 104, 2288, 8978, 29538, 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المنطقة", "probability": 0.969482421875}], "temperature": 1.0}, {"id": 23, "seek": 52351, "start": 499.43, "end": 523.51, "text": "فالآن هنحقنه بيحقن as much as possible في منطقة العضة والباقي بيحقنه intramuscularly ليش intramuscularly؟ بدنا ييروح على الدم، ليش بدنا ييروح على الدم؟ عشان إذا فيروس escaped من المنطقة اللي هي منطقة العضة، يلاقي هذا اللي هو ال antibody لما له أيضا neutralization", "tokens": [5172, 6027, 148, 48506, 8032, 1863, 5016, 4587, 1863, 3224, 4724, 1829, 5016, 4587, 1863, 382, 709, 382, 1944, 8978, 9154, 9566, 28671, 18863, 11242, 3660, 16070, 3555, 995, 38436, 4724, 1829, 5016, 4587, 1863, 3224, 560, 2356, 301, 17792, 356, 32239, 8592, 560, 2356, 301, 17792, 356, 22807, 47525, 8315, 7251, 13546, 2407, 5016, 15844, 32748, 2304, 12399, 32239, 8592, 47525, 8315, 7251, 13546, 2407, 5016, 15844, 32748, 2304, 22807, 6225, 8592, 7649, 11933, 15730, 8978, 32887, 3794, 20397, 9154, 9673, 1863, 9566, 28671, 13672, 1829, 39896, 9154, 9566, 28671, 18863, 11242, 3660, 12399, 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بنادمين متطوعين بنعملهم hyper immunization نعطيهم جرعة كبيرة من ال vaccine فبصير لديهم كمية كبيرة من ال antibody", "tokens": [27842, 4032, 9957, 44945, 7435, 1829, 3555, 2423, 34507, 22807, 9154, 44650, 9566, 45367, 9957, 44945, 18513, 2304, 9957, 44650, 9566, 45367, 9957, 44945, 25957, 1211, 16095, 9848, 13154, 2144, 8717, 3615, 9566, 1829, 16095, 10874, 2288, 27884, 9122, 3555, 48923, 9154, 2423, 7007, 6156, 3555, 9381, 13546, 5296, 16254, 16095, 9122, 2304, 10632, 9122, 3555, 48923, 9154, 2423, 34507], "avg_logprob": -0.19351946037323747, "compression_ratio": 1.5810810810810811, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 525.18, "end": 525.4, "word": "من", "probability": 0.8525390625}, {"start": 525.4, "end": 525.56, "word": " وين", "probability": 0.819091796875}, {"start": 525.56, "end": 525.88, "word": " بنجيب", "probability": 0.9652099609375}, {"start": 525.88, "end": 525.98, "word": " ال", "probability": 0.974609375}, {"start": 525.98, "end": 526.8, "word": " 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on antibody being present in many members of the pool الفعالية معتمدة عالمين على جداش في antibodies موجودة أصلا في الأشخاص اللي أخدنا منهم أو هذه العينات", "tokens": [3555, 47283, 3215, 9122, 10943, 9122, 3555, 13546, 9154, 21136, 13546, 10943, 46599, 34268, 2304, 3215, 6225, 42213, 10632, 14634, 24976, 13154, 45841, 12176, 259, 8978, 29538, 21542, 6027, 3660, 21208, 295, 13154, 45841, 12176, 259, 307, 2361, 322, 34507, 885, 1974, 294, 867, 2679, 295, 264, 7005, 27188, 3615, 6027, 10632, 3714, 34268, 2304, 41891, 6225, 45340, 9957, 15844, 10874, 3215, 33599, 8978, 28356, 3714, 29245, 23328, 3660, 5551, 9381, 15040, 8978, 16247, 8592, 9778, 33546, 13672, 1829, 5551, 9778, 3215, 8315, 9154, 16095, 34051, 29538, 18863, 1829, 8315, 2655], "avg_logprob": -0.2758152083210323, "compression_ratio": 1.5617529880478087, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1025.53, "end": 1026.57, "word": "باخد", "probability": 0.7307942708333334}, {"start": 1026.57, "end": 1027.39, 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{"start": 1042.67, "end": 1042.93, "word": " of", "probability": 0.96826171875}, {"start": 1042.93, "end": 1043.27, "word": " the", "probability": 0.81005859375}, {"start": 1043.27, "end": 1043.59, "word": " pool", "probability": 0.85791015625}, {"start": 1043.59, "end": 1045.63, "word": " الفعالية", "probability": 0.733551025390625}, {"start": 1045.63, "end": 1046.09, "word": " معتمدة", "probability": 0.912841796875}, {"start": 1046.09, "end": 1046.67, "word": " عالمين", "probability": 0.7613932291666666}, {"start": 1046.67, "end": 1047.17, "word": " على", "probability": 0.779296875}, {"start": 1047.17, "end": 1047.61, "word": " جداش", "probability": 0.7364908854166666}, {"start": 1047.61, "end": 1047.77, "word": " في", "probability": 0.6533203125}, {"start": 1047.77, "end": 1048.29, "word": " antibodies", "probability": 0.7509765625}, {"start": 1048.29, "end": 1048.85, "word": " موجودة", "probability": 0.9757080078125}, {"start": 1048.85, "end": 1049.19, "word": " أصلا", "probability": 0.83837890625}, {"start": 1049.19, "end": 1049.45, "word": " في", "probability": 0.94091796875}, {"start": 1049.45, "end": 1049.97, "word": " الأشخاص", "probability": 0.9727783203125}, {"start": 1049.97, "end": 1050.07, "word": " اللي", "probability": 0.934814453125}, {"start": 1050.07, "end": 1050.51, "word": " أخدنا", "probability": 0.8455810546875}, {"start": 1050.51, "end": 1050.91, "word": " منهم", "probability": 0.99267578125}, {"start": 1050.91, "end": 1052.61, "word": " أو", "probability": 0.2445068359375}, {"start": 1052.61, "end": 1052.95, "word": " هذه", "probability": 0.9140625}, {"start": 1052.95, "end": 1053.93, "word": " العينات", "probability": 0.8975830078125}], "temperature": 1.0}, {"id": 46, "seek": 107949, "start": 1055.85, "end": 1079.49, "text": "مصطلح رائع جدا ومفهوم لازم نكون فاهمينه في المناعة اسمه herd immunity و herd باللغة العربية معناها القطيع وبدما انه احنا بنتكلم معاهم بالادمين فيعني مش صح انه انه ان نعيد نفس اللغة و الحقيقة الصحيحة فيها التراب على المصطلح هو انه اصبح اسمها community immunity", "tokens": [2304, 9381, 9566, 1211, 5016, 12602, 16373, 3615, 10874, 28259, 4032, 2304, 5172, 3224, 20498, 5296, 31377, 2304, 8717, 30544, 6156, 40294, 2304, 9957, 3224, 8978, 9673, 8315, 27884, 24525, 2304, 3224, 29484, 22701, 4032, 29484, 20666, 1211, 17082, 3660, 18863, 25513, 10632, 20449, 8315, 11296, 25062, 9566, 40228, 4032, 44510, 15042, 16472, 3224, 1975, 5016, 8315, 4724, 29399, 4117, 19528, 20449, 995, 16095, 20666, 18513, 2304, 9957, 6156, 40228, 22653, 37893, 20328, 5016, 16472, 3224, 16472, 3224, 16472, 8717, 3615, 25708, 8717, 36178, 13672, 17082, 3660, 4032, 21542, 38436, 28671, 31767, 5016, 1829, 5016, 3660, 8978, 11296, 16712, 2288, 16758, 15844, 9673, 9381, 9566, 1211, 5016, 31439, 16472, 3224, 1975, 9381, 49628, 24525, 2304, 11296, 1768, 22701], "avg_logprob": -0.23476890355599025, "compression_ratio": 1.8257261410788381, "no_speech_prob": 8.940696716308594e-07, "words": [{"start": 1055.85, "end": 1056.51, 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"probability": 0.55830078125}, {"start": 1075.23, "end": 1075.37, "word": " فيها", "probability": 0.94091796875}, {"start": 1075.37, "end": 1075.67, "word": " التراب", "probability": 0.6832682291666666}, {"start": 1075.67, "end": 1075.81, "word": " على", "probability": 0.56298828125}, {"start": 1075.81, "end": 1076.55, "word": " المصطلح", "probability": 0.98857421875}, {"start": 1076.55, "end": 1076.71, "word": " هو", "probability": 0.9091796875}, {"start": 1076.71, "end": 1077.05, "word": " انه", "probability": 0.49798583984375}, {"start": 1077.05, "end": 1077.33, "word": " اصبح", "probability": 0.7710774739583334}, {"start": 1077.33, "end": 1077.81, "word": " اسمها", "probability": 0.9676106770833334}, {"start": 1077.81, "end": 1078.41, "word": " community", "probability": 0.927734375}, {"start": 1078.41, "end": 1079.49, "word": " immunity", "probability": 0.9736328125}], "temperature": 1.0}, {"id": 47, "seek": 108665, "start": 1080.17, "end": 1086.65, "text": "إنها يتعبر عن المجموعة وبالتالي بدأ المنجول يقطع المنجول يتكلم عن بني أدمين", "tokens": [28814, 1863, 11296, 7251, 2655, 3615, 3555, 2288, 18871, 9673, 7435, 2304, 2407, 27884, 46599, 6027, 2655, 6027, 1829, 47525, 10721, 9673, 1863, 7435, 12610, 7251, 47432, 3615, 9673, 1863, 7435, 12610, 7251, 2655, 4117, 19528, 18871, 4724, 22653, 5551, 40448, 9957], "avg_logprob": -0.31831396180529925, "compression_ratio": 1.4680851063829787, "no_speech_prob": 0.0, "words": [{"start": 1080.17, "end": 1080.47, "word": "إنها", "probability": 0.5760091145833334}, {"start": 1080.47, "end": 1080.87, "word": " يتعبر", "probability": 0.7696533203125}, {"start": 1080.87, "end": 1081.17, "word": " عن", "probability": 0.9521484375}, {"start": 1081.17, "end": 1082.85, "word": " المجموعة", "probability": 0.92822265625}, {"start": 1082.85, "end": 1083.61, "word": " وبالتالي", "probability": 0.930078125}, {"start": 1083.61, "end": 1083.95, "word": " بدأ", "probability": 0.69873046875}, {"start": 1083.95, "end": 1084.25, "word": " 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1365.56, "word": " معظمهم", "probability": 0.9857177734375}, {"start": 1365.56, "end": 1366.04, "word": " وفيه", "probability": 0.6624348958333334}, {"start": 1366.04, "end": 1366.22, "word": " non", "probability": 0.845703125}, {"start": 1366.22, "end": 1367.04, "word": " immunized", "probability": 0.87060546875}, {"start": 1367.04, "end": 1367.6, "word": " تمام", "probability": 0.841796875}, {"start": 1367.6, "end": 1368.52, "word": " نسبة", "probability": 0.9498697916666666}, {"start": 1368.52, "end": 1369.1, "word": " انتقال", "probability": 0.981689453125}, {"start": 1369.1, "end": 1369.5, "word": " المرض", "probability": 0.9912109375}, {"start": 1369.5, "end": 1369.68, "word": " اللي", "probability": 0.893798828125}, {"start": 1369.68, "end": 1369.82, "word": " هم", "probability": 0.778076171875}, {"start": 1369.82, "end": 1370.34, "word": " بتكون", "probability": 0.9443359375}, {"start": 1370.34, "end": 1371.1, "word": " قليلة", "probability": 0.9490559895833334}, {"start": 1371.1, "end": 1371.42, "word": " او", "probability": 0.76220703125}, {"start": 1371.42, "end": 1371.8, "word": " شبه", "probability": 0.9676106770833334}, {"start": 1371.8, "end": 1372.32, "word": " معدهم", "probability": 0.63720703125}, {"start": 1372.32, "end": 1372.6, "word": " اذا", "probability": 0.7169189453125}, {"start": 1372.6, "end": 1373.3, "word": " the", "probability": 0.712890625}, {"start": 1373.3, "end": 1373.66, "word": " more", "probability": 0.9599609375}, {"start": 1373.66, "end": 1374.5, "word": " immunized", "probability": 0.98876953125}], "temperature": 1.0}, {"id": 59, "seek": 139395, "start": 1375.21, "end": 1393.95, "text": "people are the more protected than immunized people فهذه هي الفكرة العامة لكن كما ذكرت هي مش فكرة absolute بجهة إن كنت انتهينا من الفصل اللي اسمه viral vaccine أرجو أن تكونوا بالفعل استفدته من هذا الفصل نكمل المرة القادمة إن شاء الله", "tokens": [21123, 366, 264, 544, 10594, 813, 13154, 1602, 561, 6156, 3224, 24192, 39896, 27188, 4117, 25720, 18863, 10943, 3660, 44381, 9122, 15042, 29910, 37983, 2655, 39896, 37893, 6156, 4117, 25720, 8236, 4724, 7435, 3224, 3660, 36145, 9122, 29399, 16472, 47395, 1829, 8315, 9154, 27188, 36520, 13672, 1829, 24525, 2304, 3224, 16132, 7007, 5551, 47341, 2407, 14739, 6055, 30544, 14407, 20666, 5172, 30241, 44713, 5172, 3215, 47395, 9154, 23758, 27188, 36520, 8717, 24793, 1211, 9673, 25720, 25062, 18513, 46007, 36145, 13412, 16606, 21984], "avg_logprob": -0.25263555150434197, "compression_ratio": 1.6363636363636365, "no_speech_prob": 1.9073486328125e-06, "words": [{"start": 1375.21, "end": 1375.61, "word": "people", "probability": 0.331298828125}, {"start": 1375.61, "end": 1376.65, "word": " are", "probability": 0.94091796875}, {"start": 1376.65, "end": 1377.33, "word": " the", "probability": 0.86376953125}, {"start": 1377.33, "end": 1377.59, "word": " more", "probability": 0.8896484375}, {"start": 1377.59, "end": 1378.21, "word": " protected", "probability": 0.84033203125}, {"start": 1378.21, "end": 1378.65, "word": " than", "probability": 0.47412109375}, {"start": 1378.65, "end": 1379.69, "word": " immunized", "probability": 0.833984375}, {"start": 1379.69, "end": 1380.19, "word": " people", "probability": 0.9638671875}, {"start": 1380.19, "end": 1380.45, "word": " فهذه", "probability": 0.6809895833333334}, {"start": 1380.45, "end": 1380.69, "word": " هي", "probability": 0.3232421875}, {"start": 1380.69, "end": 1381.07, "word": " الفكرة", "probability": 0.9912109375}, {"start": 1381.07, "end": 1381.55, "word": " العامة", "probability": 0.9860026041666666}, {"start": 1381.55, "end": 1381.79, "word": " لكن", "probability": 0.70654296875}, {"start": 1381.79, "end": 1382.01, "word": " كما", "probability": 0.921142578125}, {"start": 1382.01, "end": 1382.43, "word": " ذكرت", "probability": 0.96728515625}, {"start": 1382.43, "end": 1382.77, "word": " هي", "probability": 0.8095703125}, {"start": 1382.77, "end": 1382.97, "word": " مش", "probability": 0.974609375}, {"start": 1382.97, "end": 1383.31, "word": " فكرة", "probability": 0.9837239583333334}, {"start": 1383.31, "end": 1384.07, "word": " absolute", "probability": 0.7060546875}, {"start": 1384.07, "end": 1384.69, "word": " بجهة", "probability": 0.4857177734375}, {"start": 1384.69, "end": 1384.77, "word": " إن", "probability": 0.318115234375}, {"start": 1384.77, "end": 1385.17, "word": " كنت", "probability": 0.797607421875}, {"start": 1385.17, "end": 1385.85, "word": " انتهينا", "probability": 0.839599609375}, {"start": 1385.85, "end": 1386.07, "word": " من", "probability": 0.9873046875}, {"start": 1386.07, "end": 1386.95, "word": " الفصل", "probability": 0.92822265625}, {"start": 1386.95, "end": 1387.29, "word": " اللي", "probability": 0.64892578125}, {"start": 1387.29, "end": 1387.75, "word": " اسمه", "probability": 0.9519856770833334}, {"start": 1387.75, "end": 1388.41, "word": " viral", "probability": 0.400146484375}, {"start": 1388.41, "end": 1389.01, "word": " vaccine", "probability": 0.94580078125}, {"start": 1389.01, "end": 1389.63, "word": " أرجو", "probability": 0.8035481770833334}, {"start": 1389.63, "end": 1389.73, "word": " أن", "probability": 0.51611328125}, {"start": 1389.73, "end": 1390.45, "word": " تكونوا", "probability": 0.8982747395833334}, {"start": 1390.45, "end": 1390.71, "word": " بالفعل", "probability": 0.95947265625}, {"start": 1390.71, "end": 1391.15, "word": " استفدته", "probability": 0.810791015625}, {"start": 1391.15, "end": 1391.31, "word": " من", "probability": 0.9873046875}, {"start": 1391.31, "end": 1391.69, "word": " هذا", "probability": 0.9453125}, {"start": 1391.69, "end": 1392.47, "word": " الفصل", "probability": 0.98291015625}, {"start": 1392.47, "end": 1393.01, "word": " نكمل", "probability": 0.8756510416666666}, {"start": 1393.01, "end": 1393.21, "word": " المرة", "probability": 0.771728515625}, {"start": 1393.21, "end": 1393.55, "word": " القادمة", "probability": 0.9856770833333334}, {"start": 1393.55, "end": 1393.69, "word": " إن", "probability": 0.54443359375}, {"start": 1393.69, "end": 1393.83, "word": " شاء", "probability": 0.96923828125}, {"start": 1393.83, "end": 1393.95, "word": " الله", "probability": 0.94921875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1394.079625, "duration_after_vad": 1314.8099999999981}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..2674a3a0f14a71b028799ae4747831979a6a000c
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/ayqgridB5ZQ_raw.srt
@@ -0,0 +1,1260 @@
+1
+00:00:21,060 --> 00:00:23,300
+بسم الله الرحمن الرحيم احنا المحاضرة الماضية بدأنا
+
+2
+00:00:23,300 --> 00:00:27,620
+في ال viral vaccine وما انتهينا منه فقبل ما نكمل
+
+3
+00:00:27,620 --> 00:00:30,820
+ان شاء الله هنمر مرور سريع على المعلومات اللي مرنا
+
+4
+00:00:30,820 --> 00:00:35,060
+عليها بشرح المرة الماضيةواتحدثنا على ان ال viral
+
+5
+00:00:35,060 --> 00:00:39,620
+vaccines كتير مهمة اللي بسبب انه ليس لدينا
+
+6
+00:00:39,620 --> 00:00:43,460
+antivirals بكفاءة ال antibiotics وبالتالي احنا
+
+7
+00:00:43,460 --> 00:00:47,860
+محتاجين نمنع جلنا اللي هو ال disease اتجسسنا
+
+8
+00:00:47,860 --> 00:00:53,140
+الموضوع المتعلق بمنع ضد الفيروسات او بالتطعيم او
+
+9
+00:00:53,140 --> 00:00:56,690
+بالتحصين للفيروساتإلى active immunity و passive
+
+10
+00:00:56,690 --> 00:01:00,190
+immunity واتكلمنا عن اللي هو ال vaccines اللي هي
+
+11
+00:01:00,190 --> 00:01:05,110
+بتعمل induction active immunity و ال vaccines
+
+12
+00:01:07,210 --> 00:01:11,230
+قسمناهم لقسمين رئيسيا ياما live attenuated أو
+
+13
+00:01:11,230 --> 00:01:14,850
+killed وجيبنا كمان نوع تالت اللي هو سمناها subunit
+
+14
+00:01:14,850 --> 00:01:18,410
+vaccine وكنا هذا بينطبق عليه ما ينطبق على ال
+
+15
+00:01:18,410 --> 00:01:22,690
+killed vaccine وحاولنا نعمل مقارنة بين التنين
+
+16
+00:01:22,690 --> 00:01:25,510
+والحقيقة ان جدول هذا كان هو الأهم على الإطلاق في
+
+17
+00:01:25,510 --> 00:01:30,330
+كل المحاضرة لإنه بعطينا فكرة عن مزالة وعيوب كل من
+
+18
+00:01:30,330 --> 00:01:32,890
+ال killed و ال live vaccine والسؤال اللي انا
+
+19
+00:01:32,890 --> 00:01:36,350
+اتسألته وقلتلكوا ماتجهوش عليه بالذكاءهو سؤال مين
+
+20
+00:01:36,350 --> 00:01:40,190
+أحسن؟ قلنا لكم أنه قد لا نستطيع الحصول على أحد من
+
+21
+00:01:40,190 --> 00:01:43,810
+الأثنين، وبالتالي الأفضل هو الذي يستخدم ال
+
+22
+00:01:43,810 --> 00:01:49,330
+situation ويقوم على حل هذه المسألة، لكن باختصار ال
+
+23
+00:01:49,330 --> 00:01:53,870
+effectiveness تباعالـ Live Vaccine كان أحسن بكتير
+
+24
+00:01:53,870 --> 00:01:58,470
+من الـ Killed Vaccine لأنه بيحفظ مش فقط الـ IgG
+
+25
+00:01:58,470 --> 00:02:02,390
+وإنما كمان الـ IgA بالإضافة إلى الـ Cell Mediated
+
+26
+00:02:02,390 --> 00:02:06,470
+Immunity وهذا أمر جيد جدا في الـ Viral Infection
+
+27
+00:02:08,080 --> 00:02:14,140
+اتكلمنا عن بعض الأيوب المتعلقة بالـ live vaccine
+
+28
+00:02:14,140 --> 00:02:18,340
+أو بالأحرى مخاوف، و ذكرنا ثلاث مخاوف، جونا الأول
+
+29
+00:02:18,340 --> 00:02:22,780
+أنه يصبح هناك reversion من الـ attenuated إلى الـ
+
+30
+00:02:22,780 --> 00:02:26,440
+violent، رقم اتنين يصبح له shedding في البيئة، إن
+
+31
+00:02:26,440 --> 00:02:30,500
+الإنسان اللي أخذ تطييب ينتج هذا الفيروس إلى الـ
+
+32
+00:02:30,500 --> 00:02:33,900
+environment ويبدأ ينقل المرض للآخرين،و أقم تلاتة
+
+33
+00:02:33,900 --> 00:02:38,740
+اللي هو إنه يكون فيه contamination لل .. للفيروس ب
+
+34
+00:02:38,740 --> 00:02:42,860
+second virus هذه ال .. أو النقطة الثالثة كنا
+
+35
+00:02:42,860 --> 00:02:46,700
+بيشترك فيها كل من ال live و ال .. و ال .. و ال
+
+36
+00:02:46,700 --> 00:02:49,220
+killed لكن الخطر الأكبر في ال live أنه إحنا
+
+37
+00:02:49,220 --> 00:02:53,760
+بنعرضوش لأي معالجة لقتل الفيروس و لتالي ال
+
+38
+00:02:53,760 --> 00:03:00,000
+contaminant هيكون live تمام برضه حقيقيذكرنا إنه في
+
+39
+00:03:00,000 --> 00:03:05,420
+بعض ال .. في مخاوف أخرى من وجود حساسية خاصة ل ..
+
+40
+00:03:05,420 --> 00:03:09,340
+لدى الأشخاص اللي حاسسين لأحد مشتقات البيض لإنه في
+
+41
+00:03:09,340 --> 00:03:12,860
+بعض ال vaccines تنتج في ال chick embryo أو الجنين
+
+42
+00:03:12,860 --> 00:03:14,420
+تبع الدجاجة
+
+43
+00:03:18,330 --> 00:03:22,110
+اتعلننا مصطلحين الـ pre exposure و ال post
+
+44
+00:03:22,110 --> 00:03:25,970
+exposure و قلنا ان ال pre exposure هو الذي يعني
+
+45
+00:03:25,970 --> 00:03:30,270
+ادارج ان احنا بناخد الفاكسين قبل ما نتعرض للفيروس
+
+46
+00:03:30,270 --> 00:03:35,630
+لكن في بعض الأحيان انسان عده كلب مسهور تمام هذا
+
+47
+00:03:35,630 --> 00:03:39,010
+تعرض للفيروس already تعرضفهل يمكن أن نعطيه فاكسين
+
+48
+00:03:39,010 --> 00:03:42,070
+بعد ما اتعرض هذا اسمه post exposure؟ واحد تعرض
+
+49
+00:03:42,070 --> 00:03:45,810
+لغزة إبرة Hepatitis تمام؟ هل نعطيه فاكسين بعد ما
+
+50
+00:03:45,810 --> 00:03:48,630
+اتعرض ولا ما نعطيهوش؟ وهل بينفع الكلام هذا في كل
+
+51
+00:03:48,630 --> 00:03:52,610
+الحالات؟ ولا فقط في حالات معينة؟ هذا ذكرنا احنا
+
+52
+00:03:52,610 --> 00:03:56,050
+مثلين فقط اللي هو ال rapist وال hepatitis B الكلام
+
+53
+00:03:56,050 --> 00:04:01,360
+هو ايضا عن مستقبل الفاكسين واتحدثنا عن البعضال ..
+
+54
+00:04:01,360 --> 00:04:04,320
+ال .. ال .. خدنا نقول الأفاق التي يعمل عليها
+
+55
+00:04:04,320 --> 00:04:08,500
+العلماء حاليا في موضوع ال vaccine مثل إيش؟ مثل إنه
+
+56
+00:04:08,500 --> 00:04:14,700
+أنا أستخدم DNA vaccine أو أستخدم subunit vaccine
+
+57
+00:04:14,700 --> 00:04:19,160
+أو أستخدم viral vaccine يعني vaccine عبارة عن
+
+58
+00:04:19,160 --> 00:04:24,920
+فيروس مليان جينات لفيروسات و مايكروبات أخرىبنحقن
+
+59
+00:04:24,920 --> 00:04:28,200
+المريض ب one virus لكن واقعال اول حد بنطعمه ضد
+
+60
+00:04:28,200 --> 00:04:33,280
+مجموعة كبيرة من الفيروسات او الميكروبات الاخرى DNA
+
+61
+00:04:33,280 --> 00:04:38,370
+VaccineVirus to vaccinate against other viruses
+
+62
+00:04:38,370 --> 00:04:41,930
+وشفنا انه بدلا كل smallpox او ال vaccine هي virus
+
+63
+00:04:41,930 --> 00:04:47,630
+بالاخرى هو المرشح لهذا الموضوع ايضا تحدثنا عن بعض
+
+64
+00:04:47,630 --> 00:04:51,690
+ال vaccines الفيروسية اللي بناخدها بشكل common
+
+65
+00:04:51,690 --> 00:04:55,850
+بشكل روتيني وبعض ال vaccines اللي فقط بناخدها
+
+66
+00:04:55,850 --> 00:05:00,530
+during special situations يعني أوضاع خاصة مثل
+
+67
+00:05:00,530 --> 00:05:06,670
+السفر بين مناطق موبوعة ممكن خلال حروب الاخرأيضا
+
+68
+00:05:06,670 --> 00:05:10,370
+تحدثنا عن ال .. ال vaccines اللي بتوعطل الأطفال أو
+
+69
+00:05:10,370 --> 00:05:14,050
+يوصل إن الأطفال ياخدوها من سن يوم إلى ست سنوات
+
+70
+00:05:14,050 --> 00:05:17,130
+سببها كانت bacterial vaccine أو viral vaccine
+
+71
+00:05:17,130 --> 00:05:20,850
+وتوقفنا عند هذه اللوحة اللي هي ال passive immunity
+
+72
+00:05:20,850 --> 00:05:25,730
+وال passive immunityسميت passive لأنه مافيش جهد
+
+73
+00:05:25,730 --> 00:05:30,310
+بيبذل من قبل العائل لإنتاج أجسام مضادة احنا
+
+74
+00:05:30,310 --> 00:05:35,470
+بنجهزله أجسام مضادة خارج جسمه و بنعطيها جهزة كيف
+
+75
+00:05:35,470 --> 00:05:40,150
+بنجهزله إيها؟ إما بتكون من مصدر حيواني أو من مصدر
+
+76
+00:05:40,150 --> 00:05:49,060
+آدمي بمعنى تتذكروا ال rabid؟people مش بنعطيهم احنا
+
+77
+00:05:49,060 --> 00:05:52,300
+vaccine لو بنعطيهم vaccine ايش بيصير في دم هم دولة
+
+78
+00:05:52,300 --> 00:05:56,280
+اجسام مضادة بنجمعلنا عشر اشخاص من اللي انصابوا بال
+
+79
+00:05:56,280 --> 00:05:59,460
+rabies قبلك او اتعرضوا لل rabies واخدوا vaccine
+
+80
+00:05:59,460 --> 00:06:03,520
+الان في اجسامهم اجسام مضادة جاهزة بناخد منهم عينات
+
+81
+00:06:03,520 --> 00:06:07,380
+دم وبنفصل ال antibodies سبعة ال rabies وبنعطيها
+
+82
+00:06:07,380 --> 00:06:14,100
+لمريض اخر اذا ممكن نحضرها في انسان وفي بعضالـ
+
+83
+00:06:14,100 --> 00:06:17,160
+Immunoglobulin ممكن تحضر فيه أيضا في حيوانات لكن
+
+84
+00:06:17,160 --> 00:06:22,960
+يبقى الخشية لما يكون المصدر للاجسام المضاد من
+
+85
+00:06:22,960 --> 00:06:26,720
+حيواني ان يكون فيه hypersensitivity يعني نوع من
+
+86
+00:06:26,720 --> 00:06:31,940
+ايه؟ من الحساسية ضد هذه الأجسام في مصطلح قلنا عنه
+
+87
+00:06:31,940 --> 00:06:35,180
+passive active immunity يعني قلنا passive active
+
+88
+00:06:35,180 --> 00:06:37,080
+immunity vaccine و passive immunity بنعطي
+
+89
+00:06:37,080 --> 00:06:40,640
+immunoglobulin طب لما يكون المصطلح passive active
+
+90
+00:06:40,640 --> 00:06:45,720
+immunity بدنا نعطي اتنين مع بعضماذا نعطيه مع بعض؟
+
+91
+00:06:45,720 --> 00:06:48,440
+نعطيه الـ Immunoglobulin اللي هو الـ Passive و
+
+92
+00:06:48,440 --> 00:06:53,400
+نعطيه الـ Vaccine و هذا الكلام ينطبق تماما على نفس
+
+93
+00:06:53,400 --> 00:06:57,800
+الحالتين اللي أنا ذكرتهم للـ Post Exposure منهم
+
+94
+00:06:57,800 --> 00:07:03,140
+الـ Rares و الـ Hepatitis تعالى نطلع على ال
+
+95
+00:07:03,140 --> 00:07:09,120
+Immunoglobulin اللي هي جنة تدخل ضمن إطار ال
+
+96
+00:07:09,120 --> 00:07:14,310
+Vaccination اللي هي الـ RIG و الـ RIG اختصارRapes
+
+97
+00:07:14,310 --> 00:07:19,250
+immunoglobulin تستخدم
+
+98
+00:07:19,250 --> 00:07:24,550
+في ال prevention للرايبز في الأشخاص الذين تعرضوا
+
+99
+00:07:24,550 --> 00:07:29,390
+للفيروس كيف تعرضوا للفيروس؟ إما يكون عضة من حيوان
+
+100
+00:07:29,390 --> 00:07:33,650
+رابد، رابد يعني مصاب بي اللي هو ال rapes أو ممكن
+
+101
+00:07:33,650 --> 00:07:38,490
+تعرضة saliva من خفافيش تمام؟ الخفافيش ممكن تنقل ال
+
+102
+00:07:38,490 --> 00:07:43,950
+rapes عبر اللي هو ال salivaبنطلع الآن على الوسيلة
+
+103
+00:07:43,950 --> 00:07:48,090
+أو الكيفية اللى بتم إعطاء فيها الـ Reg للأشخاص
+
+104
+00:07:48,750 --> 00:07:54,430
+Inject as much rig as possible into the tissue at
+
+105
+00:07:54,430 --> 00:07:58,430
+the bite site اذا كان في عضة فاحقن قدر بيتها
+
+106
+00:07:58,430 --> 00:08:02,270
+استطيع من ايه من ال immunoglobulin ليش؟ بقول ان ال
+
+107
+00:08:02,270 --> 00:08:05,630
+immunoglobulin ترتبط بالفيروس و بتعمل
+
+108
+00:08:05,630 --> 00:08:08,930
+neutralization للفيروس فالفيروس في هذا الحالة لن
+
+109
+00:08:08,930 --> 00:08:12,750
+يستطيع الدخول الى الخلايا و لن يتكاثر فانت بتقليلي
+
+110
+00:08:12,750 --> 00:08:17,150
+احتمالية ان الفيروس ايه يتكاثر في هذه المنطقة
+
+111
+00:08:19,430 --> 00:08:23,770
+فالآن هنحقنه بيحقن as much as possible في منطقة
+
+112
+00:08:23,770 --> 00:08:28,850
+العضة والباقي بيحقنه intramuscularly ليش
+
+113
+00:08:28,850 --> 00:08:32,830
+intramuscularly؟ بدنا ييروح على الدم، ليش بدنا
+
+114
+00:08:32,830 --> 00:08:37,750
+ييروح على الدم؟ عشان إذا فيروس escaped من المنطقة
+
+115
+00:08:37,750 --> 00:08:41,630
+اللي هي منطقة العضة، يلاقي هذا اللي هو ال antibody
+
+116
+00:08:41,630 --> 00:08:45,980
+لما له أيضا neutralizationمن وين بنجيب ال
+
+117
+00:08:45,980 --> 00:08:51,520
+antibody؟ من متطوعين
+
+118
+00:08:51,520 --> 00:08:56,700
+بنادمين متطوعين بنعملهم hyper immunization نعطيهم
+
+119
+00:08:56,700 --> 00:09:05,120
+جرعة كبيرة من ال vaccine فبصير لديهم كمية كبيرة من
+
+120
+00:09:05,120 --> 00:09:05,880
+ال antibody
+
+121
+00:09:09,130 --> 00:09:12,310
+Rig is obtained from human to avoid
+
+122
+00:09:12,310 --> 00:09:15,610
+hypersensitivity reactions وهذا الكلام قدّمناله
+
+123
+00:09:15,610 --> 00:09:18,910
+وقلنا لكوا إنه لو كان المصدر الحيواني الخشية
+
+124
+00:09:18,910 --> 00:09:24,750
+موجودة من أن يحدث هناك تثاعر حساسية type 1
+
+125
+00:09:24,750 --> 00:09:28,950
+hypersensitivity أو anaphylactic shock
+
+126
+00:09:31,860 --> 00:09:34,580
+In addition to reg, the vaccine containing killed
+
+127
+00:09:34,580 --> 00:09:39,080
+virus made in human-deployed cells should be given
+
+128
+00:09:39,080 --> 00:09:44,760
+يبقى هنا نموذج رائع على active passive immunity
+
+129
+00:09:44,760 --> 00:09:48,240
+انا استخدمت immunoglobulin و في نفس الولد يقعد
+
+130
+00:09:48,240 --> 00:09:55,060
+بستخدم vaccine ليش بينجح هذا الكلام في ال rabies؟
+
+131
+00:09:55,090 --> 00:09:58,370
+ونال ريبز و الهيباطيتس في إيه اللي هم ميزة؟ إن
+
+132
+00:09:58,370 --> 00:10:02,770
+الاتنين كلاهما اندو incubation period طويلة
+
+133
+00:10:02,770 --> 00:10:06,890
+وبالتالي طول ال incubation period هذا بيسهل على
+
+134
+00:10:06,890 --> 00:10:10,810
+جسمنا أنه أبعد فرصة للجسم تبعنا إنه يكون أجسام
+
+135
+00:10:10,810 --> 00:10:15,530
+مضادة حتى بعد اللي هو ال exposure بينما هذا الكلام
+
+136
+00:10:15,530 --> 00:10:20,070
+غير صحيح في كثير من الفيروسات يعني لو افترضنا
+
+137
+00:10:20,070 --> 00:10:24,210
+نتعرضنا ل ال missiles تمام؟ مينفعش أعطي فاكسين بعد
+
+138
+00:10:24,210 --> 00:10:30,180
+التعرضخلاص الآن ال .. ال .. الفيروس already
+
+139
+00:10:30,180 --> 00:10:32,680
+established .. already established لكن في الـ
+
+140
+00:10:32,680 --> 00:10:36,140
+hepatitis والرابس فيه نوعا ما long incubation
+
+141
+00:10:36,140 --> 00:10:39,720
+period تسمح للجسم انه يكون antibody لو احنا
+
+142
+00:10:39,720 --> 00:10:43,620
+اعطيناه الفاكسينة الفاكسينة وانا محضر .. محضر على
+
+143
+00:10:43,620 --> 00:10:47,600
+human deployed cells يعني cell culture آدمية أيضا
+
+144
+00:10:47,600 --> 00:10:53,220
+حتى نقلل من إمكانية ان يكون فيه أيضا حساسينRig
+
+145
+00:10:53,220 --> 00:10:55,540
+اللي هو قلنا rape is immunoglobulin and the
+
+146
+00:10:55,540 --> 00:10:58,400
+vaccine should be given a different size إذا نعضّى
+
+147
+00:10:58,400 --> 00:11:02,020
+في الرجل الشمال، بنعطي ال vaccine في الإيد اليمين،
+
+148
+00:11:02,020 --> 00:11:05,120
+منين يبعد ال vaccine عن مين؟ عن اللي هو ال
+
+149
+00:11:05,120 --> 00:11:10,290
+immunoglobulinبدناش ال immunoglobulin يتفاعل مع ال
+
+150
+00:11:10,290 --> 00:11:12,010
+vaccine أو مع ال neutralization، احنا بدنا ال
+
+151
+00:11:12,010 --> 00:11:15,490
+vaccine يشتغل، بدنا ال vaccine يشتغل، و هذا السيما
+
+152
+00:11:15,490 --> 00:11:18,510
+ما .. ما .. ما ذكرناه على ال rabies ينطبق أيضا على
+
+153
+00:11:18,510 --> 00:11:22,370
+مين؟ على ال hepatitis ب immunoglobulin، this is an
+
+154
+00:11:22,370 --> 00:11:27,750
+example أو an clear example of active passive
+
+155
+00:11:27,750 --> 00:11:31,390
+immunization اللي يقول إنها بتتم غالبا post
+
+156
+00:11:31,390 --> 00:11:36,710
+exposure، post exposureهل ممكن نعطي immunoglobulin
+
+157
+00:11:36,710 --> 00:11:44,950
+pre-exposure؟ الفاكسينة نحن متفقين أن الفاكسينة
+
+158
+00:11:44,950 --> 00:11:47,430
+نعطيها pre-exposure في معظم الحالات إلا في
+
+159
+00:11:47,430 --> 00:11:51,610
+الحالتين اللي ذكرناهم اللي هم ال rapes و ال .. ال
+
+160
+00:11:51,610 --> 00:11:54,650
+.. ال .. hepatitis B هل يمكن أن أعطي
+
+161
+00:11:54,650 --> 00:11:59,800
+immunoglobulin pre-exposure؟من ناحية نظرية، لو أنا
+
+162
+00:11:59,800 --> 00:12:04,320
+بدي أروح على منطقة فيها فيروس منتشر، تمام؟ فيروس
+
+163
+00:12:04,320 --> 00:12:09,040
+منتشر، والآن السفر urgent، وانا مقدرش أخد vaccine
+
+164
+00:12:09,040 --> 00:12:11,620
+عشان أنا سابد دي spike لما أكون أجسام مضادة، ممكن
+
+165
+00:12:11,620 --> 00:12:15,660
+أخد ومش ممكن أخد، ممكن ناخد immunoglobulin for pre
+
+166
+00:12:15,660 --> 00:12:18,600
+exposure لفترات قصيرة، لفترات قصيرة
+
+167
+00:12:21,180 --> 00:12:26,920
+HPIG او Hepatitis B immunoglobulin زي على أغراء
+
+168
+00:12:26,920 --> 00:12:30,260
+نفسه اللي هو ال Rig is used in the prevention of
+
+169
+00:12:30,260 --> 00:12:33,760
+Hepatitis B in people who may have been exposed
+
+170
+00:12:33,760 --> 00:12:38,000
+كلمة who have been و who have may been exposed نفس
+
+171
+00:12:38,000 --> 00:12:42,320
+الفكرة اللي حكيتلكواها الماضية انه غز إبرة من مريض
+
+172
+00:12:42,320 --> 00:12:47,700
+يحتمل ان يكون عنده مثلا Hepatitisزي الـ needle
+
+173
+00:12:47,700 --> 00:12:52,740
+stick أو الـ neonate مولود يديد لأم مثلا معروف إنه
+
+174
+00:12:52,740 --> 00:12:56,720
+عندها hepatitis أو career لل hepatitis B في هذه
+
+175
+00:12:56,720 --> 00:12:59,900
+الحالة ال immunoglobulin بتاع ال hepatitis بيكون
+
+176
+00:12:59,900 --> 00:13:03,540
+مفيد جدا ال preparation contain a high titer of
+
+177
+00:13:03,540 --> 00:13:06,760
+antibody to hepatitis B virus and is obtained from
+
+178
+00:13:06,760 --> 00:13:10,220
+human to avoid hypersensitivity reactions أيضا
+
+179
+00:13:10,220 --> 00:13:14,120
+يُأخذ من مين؟ من البشر حتى نتجنب
+
+180
+00:13:14,120 --> 00:13:19,930
+الhypersensitivityأيضا مثال آخر على active-passive
+
+181
+00:13:19,930 --> 00:13:24,410
+immunization هو هذا المثال الهيباطيتس بي وإننا
+
+182
+00:13:24,410 --> 00:13:28,430
+بنعطي vaccine وبنعطي hepatitis بي immunoglobulin
+
+183
+00:13:28,430 --> 00:13:35,470
+فيه ايضا immunoglobulin للفارسيللازوستر بتعرفوا
+
+184
+00:13:35,470 --> 00:13:37,930
+الفارسيللازوستر صار مشهورة هنا اللي هو ال chicken
+
+185
+00:13:37,930 --> 00:13:43,360
+box و الحزام الناريبرضه بيسموها Vizig أو بيريسيلة
+
+186
+00:13:43,360 --> 00:13:45,100
+زوستر امينو غليبولين بيريسيلة زوستر امينو غليبولين
+
+187
+00:13:45,100 --> 00:13:47,660
+بيريسيلة زوستر امينو غليبولين بيريسيلة زوستر امينو
+
+188
+00:13:47,660 --> 00:13:49,060
+غليبولين بيريسيلة زوستر امينو غليبولين بيريسيلة
+
+189
+00:13:49,060 --> 00:13:53,320
+زوستر امينو غليبولين بيريسيلة زوستر امينو غليبولين
+
+190
+00:13:53,320 --> 00:13:54,840
+بيريسيلة زوستر امينو غليبولين بيريسيلة زوستر امينو
+
+191
+00:13:54,840 --> 00:13:58,620
+غليبولين بيريسيلة زوستر امينو غليبولين بيريسيلة
+
+192
+00:13:58,620 --> 00:14:03,260
+زوستر امينو غليبولين بيريأيضا التحضير اللى اسمه
+
+193
+00:14:03,260 --> 00:14:07,040
+Vizig بيحتوي على high titer of antibody to
+
+194
+00:14:07,040 --> 00:14:10,720
+varicella zoster virus and is obtained from human
+
+195
+00:14:10,720 --> 00:14:13,660
+to avoid hypersensitivity reaction لحظوا الجملة
+
+196
+00:14:13,660 --> 00:14:19,120
+تكررت في الثلاثة أو في الثلاث أمثلة في ال rabies
+
+197
+00:14:19,120 --> 00:14:22,480
+في ال hepatitis B وهي كمان في varicella zoster نفس
+
+198
+00:14:22,480 --> 00:14:26,740
+الجملة لأنه يبدو أنه ال hypersensitivity reaction
+
+199
+00:14:26,740 --> 00:14:32,050
+يعني نسبتها بتكون عالية في الناس وبتاليلتجنب هذا
+
+200
+00:14:32,050 --> 00:14:37,510
+ال reaction بناخد من ال human فينا
+
+201
+00:14:37,510 --> 00:14:42,530
+مثال ال vaccine immunoglobulin ال vaccine اللي كنا
+
+202
+00:14:42,530 --> 00:14:48,530
+نستخدمها لمين؟ لل vaccination لل smallpox في بعض
+
+203
+00:14:48,530 --> 00:14:51,390
+الأطفال اللي كانوا يطعموا ال vaccine اللي كان سينا
+
+204
+00:14:51,390 --> 00:14:57,190
+عندهمخلّينا نقول disease يعني يظهر عليه أعراض ال
+
+205
+00:14:57,190 --> 00:15:02,290
+.. ال .. ال cowpox ال cowpox على هذا الطفل فعشان
+
+206
+00:15:02,290 --> 00:15:08,210
+نخفف عنه تمام كان يعطى immunoglobulin للفاكسين إذا
+
+207
+00:15:08,210 --> 00:15:13,830
+هذا كان يستخدم .. الآن لا يستخدم ليش لا يستخدم؟
+
+208
+00:15:13,830 --> 00:15:17,570
+لأن أصلا الفاكسين توقف الفاكسين توقف وماذا توقف
+
+209
+00:15:17,570 --> 00:15:23,580
+الفاكسين قلنالكوالما صارت الحالات تبع ال .. ال ..
+
+210
+00:15:23,580 --> 00:15:25,660
+ال vaccination إنها تجعل ال vaccination أعلى من
+
+211
+00:15:25,660 --> 00:15:28,580
+الحالات اللي هي acquired .. acquired by natural
+
+212
+00:15:28,580 --> 00:15:34,600
+route رقم خمسة immunoglobulin بشكل عامare useful
+
+213
+00:15:34,600 --> 00:15:38,220
+in the prevention or mitigation of hepatitis A or
+
+214
+00:15:38,220 --> 00:15:42,600
+measles in people who may have been exposed to
+
+215
+00:15:42,600 --> 00:15:45,020
+these viruses وكلمة immunoglobulin يبقى
+
+216
+00:15:45,020 --> 00:15:48,900
+immunoglobulin خاصة إما للهيباطيتس A أو خاصة
+
+217
+00:15:48,900 --> 00:15:54,080
+للميسلز يعني مش immunoglobulin بدون مسمة فحنسميها
+
+218
+00:15:54,080 --> 00:15:57,620
+hepatitis A immunoglobulins أو measles
+
+219
+00:15:57,620 --> 00:15:58,800
+immunoglobulins
+
+220
+00:16:01,860 --> 00:16:06,420
+مثلا الهيباطيتس immunoglobulins are commonly used
+
+221
+00:16:06,420 --> 00:16:10,160
+prior to traveling to area .. السؤال .. السؤال
+
+222
+00:16:10,160 --> 00:16:14,400
+السئلتك هي قبل ما ن .. ن .. نصل لهذه اللوحة أنه هل
+
+223
+00:16:14,400 --> 00:16:18,400
+بالإمكان استخدام ال immunoglobulin pre exposure
+
+224
+00:16:18,400 --> 00:16:21,700
+هاي المثال عليها أنه احنا مسافرين على منطقة فيها
+
+225
+00:16:21,700 --> 00:16:24,800
+هيباطيتس ايه ممكن ناخد immunoglobulin بدل ما ناخد
+
+226
+00:16:24,800 --> 00:16:27,820
+اللي هو ال vaccine لأن ال vaccine كمان مرة بده وجه
+
+227
+00:16:27,820 --> 00:16:33,580
+عشان ايه يشترImmunoglobulin contains pooled serum
+
+228
+00:16:33,580 --> 00:16:36,400
+obtained from a large number of human volunteers
+
+229
+00:16:36,400 --> 00:16:42,890
+who are not being hyper immunizedPooling يعني أنا
+
+230
+00:16:42,890 --> 00:16:48,130
+بجيب سيرام X وY وZ وC نصات من مجموعات مختلفة و
+
+231
+00:16:48,130 --> 00:16:52,770
+بحطهم مع بعض فمانهم بركة pooling تمام فدول الناس
+
+232
+00:16:52,770 --> 00:16:56,570
+يعني كلهم immunized مش hyper immunized فعدد ال
+
+233
+00:16:56,570 --> 00:16:59,650
+antibody إيش فيهم أو تركيز ال antibody إيش مالهم
+
+234
+00:16:59,650 --> 00:17:03,250
+بيكون قليل لإنه مش hyper immunized وبالتالي أنا
+
+235
+00:17:03,250 --> 00:17:09,770
+باخدباخد كام كبير من السيرام وبعتمد عملية
+
+236
+00:17:09,770 --> 00:17:13,930
+separation لل immunoglobulin في هذه الحالة
+
+237
+00:17:13,930 --> 00:17:19,010
+effectiveness of immunoglobulin is based on
+
+238
+00:17:19,010 --> 00:17:23,590
+antibody being present in many members of the pool
+
+239
+00:17:23,590 --> 00:17:28,290
+الفعالية معتمدة عالمين على جداش في antibodies
+
+240
+00:17:28,290 --> 00:17:32,950
+موجودة أصلا في الأشخاص اللي أخدنا منهم أو هذه
+
+241
+00:17:32,950 --> 00:17:39,990
+العيناتمصطلح رائع جدا ومفهوم لازم نكون فاهمينه في
+
+242
+00:17:39,990 --> 00:17:45,330
+المناعة اسمه herd immunity و herd باللغة العربية
+
+243
+00:17:45,330 --> 00:17:48,830
+معناها القطيع وبدما انه احنا بنتكلم معاهم بالادمين
+
+244
+00:17:48,830 --> 00:17:54,990
+فيعني مش صح انه انه ان نعيد نفس اللغة و الحقيقة
+
+245
+00:17:54,990 --> 00:17:57,810
+الصحيحة فيها التراب على المصطلح هو انه اصبح اسمها
+
+246
+00:17:57,810 --> 00:18:03,610
+community immunityإنها يتعبر عن المجموعة وبالتالي
+
+247
+00:18:03,610 --> 00:18:07,790
+بدأ المنجول يقطع المنجول يتكلم عن بني أدمينHerd
+
+248
+00:18:07,790 --> 00:18:11,490
+immunity also known as community immunity occurs
+
+249
+00:18:11,490 --> 00:18:14,850
+when sufficiently large percentages of population
+
+250
+00:18:14,850 --> 00:18:19,190
+اللي بيسموها القطية is immunized so that immunized
+
+251
+00:18:19,190 --> 00:18:23,590
+individuals non immunized individual is protected
+
+252
+00:18:23,590 --> 00:18:29,030
+اقولكوا المعنى بلغة بسيطة أو سهلة كام طالب عندى
+
+253
+00:18:29,030 --> 00:18:34,310
+هنا خمسين طالب تمام خمسة واربعين منهم مطعمين وخمسة
+
+254
+00:18:35,010 --> 00:18:39,550
+مش مطعمين هدول الخمسة المش مطعمين اللي حاميهم
+
+255
+00:18:39,550 --> 00:18:45,510
+وجودهم بين خمسة واربعين شخص مطعم يبجأ انتم ك
+
+256
+00:18:45,510 --> 00:18:49,250
+community وفرتوا مناعة لل non immunized
+
+257
+00:18:49,250 --> 00:18:54,090
+individuals كل ما زاد عدد ال immunized تمام كل
+
+258
+00:18:54,090 --> 00:18:57,930
+موفر protection اكتر للاشخاص ال non immunized طبعا
+
+259
+00:18:57,930 --> 00:19:02,910
+هذا الكلام ليس على اطلاقه و لازم نتكلم برضه فيه
+
+260
+00:19:02,910 --> 00:19:04,230
+بشكل واضح
+
+261
+00:19:09,520 --> 00:19:16,760
+لما بنتكلم عن مجتمع نسبة التطايم فيه 90% الجاليش
+
+262
+00:19:16,760 --> 00:19:20,760
+اللي مش مطعمين 10% هل تتوقعوا العشرة في المية
+
+263
+00:19:20,760 --> 00:19:24,500
+يكونوا موزعين توزيع عادل ومنتظم في ال population
+
+264
+00:19:24,500 --> 00:19:30,620
+أعطيكم مثال على أوروبا و أمريكا تمام بلدان للتطور
+
+265
+00:19:30,620 --> 00:19:35,600
+التكنولوجي في منهم جامعات أرقية ودينية بترفض
+
+266
+00:19:35,600 --> 00:19:38,420
+التطايم بترفض التطايم
+
+267
+00:19:41,400 --> 00:19:45,660
+وعايشين بطريقة ان هم منعزلين عن الآخرين بمعنى ان
+
+268
+00:19:45,660 --> 00:19:49,980
+هم لهم their own community يبقى هم مش distributed
+
+269
+00:19:49,980 --> 00:19:54,300
+فاهم عشان نذوبوا بين ال community و احنا نحميهم
+
+270
+00:19:54,300 --> 00:19:58,060
+لهم غالبا اصلا localized يعني اللي لهم مراتب خاصة
+
+271
+00:19:58,060 --> 00:20:02,420
+فلو صار في عندهم disease هينتشر بينهم بشكل كبير و
+
+272
+00:20:02,420 --> 00:20:06,430
+انا في هذا الحالةكلمة community immunity أو herd
+
+273
+00:20:06,430 --> 00:20:10,470
+immunity لن نطبق عليها مثل الصورة لكن المفهوم
+
+274
+00:20:10,470 --> 00:20:15,550
+العام لو كان العشرة في المية موزعين على كل المجتمع
+
+275
+00:20:15,550 --> 00:20:19,610
+بشكل دعنا نقول منتظم أو شبه منتظم بالفعل بتلقوا
+
+276
+00:20:19,610 --> 00:20:24,780
+حماية كيف بتلقوا حماية؟الفيروس أجاني أنا، تمام؟
+
+277
+00:20:24,780 --> 00:20:28,320
+أنا أخدته ولم أمره لأن عندي vaccination، كوني أنا
+
+278
+00:20:28,320 --> 00:20:32,820
+ماأخدته ومامردتش فمانقلتوش لمين للآخرين، فتوقف
+
+279
+00:20:32,820 --> 00:20:36,060
+عندي، فانا صار عندي الفيروس dead end، تمام؟ dead
+
+280
+00:20:36,060 --> 00:20:40,440
+end، فانا حاميت الآخرين من إنهم يصابوالذلك لما
+
+281
+00:20:40,440 --> 00:20:44,900
+نقولكوا لا تمرضوا حتى لا تنقلوا الأمراض للآخرين،
+
+282
+00:20:44,900 --> 00:20:48,680
+تمام؟ لا تمرضوا حتى لا تحصلوا على مضادات حيوية،
+
+283
+00:20:48,680 --> 00:20:52,000
+فتساهموا في نشر ال resistance تبع المضادات
+
+284
+00:20:52,000 --> 00:20:54,940
+الحيوية، وانا مستغرب صحيح ليش مش مشاركين انتوا في
+
+285
+00:20:54,940 --> 00:21:02,010
+حملة اليوم العالمي لرسل اليدين، الأصل انهانسهم
+
+286
+00:21:02,010 --> 00:21:06,950
+سويا في الحملة و احنا فينا مجموعة و الكل مشارك
+
+287
+00:21:06,950 --> 00:21:11,250
+فيها الصحيح و بدأت يعني تاخد منح واسع و trending
+
+288
+00:21:11,250 --> 00:21:13,650
+فبتقولي ارجعوا حضراتكم انكوا تشاركوا في هذه
+
+289
+00:21:13,650 --> 00:21:16,950
+المجموعة و على الأقل تعملوا sharing لبعض المنشورات
+
+290
+00:21:16,950 --> 00:21:22,610
+المتعلقة بالحملة لإن احنا نريد نشر كلمة غسل اليدين
+
+291
+00:21:22,610 --> 00:21:26,630
+ايدينا و مستقبلنا و كلمة ايدينا و مستقبلنا تعرفوا
+
+292
+00:21:26,630 --> 00:21:32,270
+إيها مدلات مهمة ان الطفل هو صغير إذا مرض كتيرغالبا
+
+293
+00:21:32,270 --> 00:21:37,090
+هذا بيفقده جزء من الصحة ممكن يفقده جزء من أيام
+
+294
+00:21:37,090 --> 00:21:42,490
+الدراسية في المدارس ممكن كمان يضعف مناته ممكن يأثر
+
+295
+00:21:42,490 --> 00:21:47,590
+على مستوى الذكاء والعقل وبالتالي بالفعل بإجراءات
+
+296
+00:21:47,590 --> 00:21:52,610
+بسيطة سهلة وميسرة يمكن انه نحافظ على صحة الأطفال
+
+297
+00:21:52,610 --> 00:21:56,410
+ومستقبلهم في هذه الحالة فنحن مطلوب منها كدارسين
+
+298
+00:21:56,410 --> 00:21:59,690
+لهذه العلوم أنه يساهم في نشر هذه الكلمة ان شاء
+
+299
+00:21:59,690 --> 00:22:03,960
+اللهنرجع لمين لل herd immunity او community
+
+300
+00:22:03,960 --> 00:22:09,260
+immunity كما ذكرت هي concept او مفهوم انه كل ما
+
+301
+00:22:09,260 --> 00:22:12,540
+زاد عدد المطعمين في المجتمع كل ما زاد حماية اللي
+
+302
+00:22:12,540 --> 00:22:17,240
+هم الأشخاص غير المطعمين ويمكن الصورة اللي قدامكم
+
+303
+00:22:17,240 --> 00:22:26,180
+هذه بتوضح الفكرة تخيلوا انه عندي في المجتمع هذا كم
+
+304
+00:22:26,180 --> 00:22:31,360
+واحد immunizedno one is immunized لو صار في عندهم
+
+305
+00:22:31,360 --> 00:22:35,680
+disease شوف كم واحد بيصير في عنده infection هاي
+
+306
+00:22:35,680 --> 00:22:38,680
+اتنين صار عندهم infection تمام الكل صار عنده
+
+307
+00:22:38,680 --> 00:22:41,000
+infection فشلا غير مجموعة بسيطة ماصلاش عندهم
+
+308
+00:22:41,000 --> 00:22:45,560
+infection لكن لما بيكونوا الناس immunized معظمهم
+
+309
+00:22:45,560 --> 00:22:49,820
+وفيه non immunized تمام نسبة انتقال المرض اللي هم
+
+310
+00:22:49,820 --> 00:22:54,500
+بتكون قليلة او شبه معدهم اذا the more immunized
+
+311
+00:22:55,210 --> 00:22:59,690
+people are the more protected than immunized
+
+312
+00:22:59,690 --> 00:23:02,970
+people فهذه هي الفكرة العامة لكن كما ذكرت هي مش
+
+313
+00:23:02,970 --> 00:23:07,290
+فكرة absolute بجهة إن كنت انتهينا من الفصل اللي
+
+314
+00:23:07,290 --> 00:23:11,150
+اسمه viral vaccine أرجو أن تكونوا بالفعل استفدته
+
+315
+00:23:11,150 --> 00:23:13,950
+من هذا الفصل نكمل المرة القادمة إن شاء الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7f0dfe152f15e58db32d0eae85fbb1f5d0cb2cbd
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho.srt
@@ -0,0 +1,2323 @@
+1
+00:00:20,970 --> 00:00:24,870
+بسم الله الرحمن الرحيم نكمل RNA-Enveloped Viruses
+
+2
+00:00:24,870 --> 00:00:28,150
+اليوم أو المحاضرة السابقة انتهينا من ال
+
+3
+00:00:28,150 --> 00:00:31,590
+Paramyxovirus دي اللي شملت مجموعة من الفيروسات زي
+
+4
+00:00:31,590 --> 00:00:34,970
+الـ Measles و الـ Mumps و الـ Para influenza و ال
+
+5
+00:00:34,970 --> 00:00:39,670
+Respiratory Syncytial Virus و بدأنا بمقدمة بسيطة
+
+6
+00:00:39,670 --> 00:00:42,810
+عن الـ Coronavirus و كنا الـ Coronavirus لم تكن
+
+7
+00:00:42,810 --> 00:00:49,840
+مشهورة قبل 2002 يعني انشهرت بعد ظهور مرض الـ SARS 
+
+8
+00:00:49,840 --> 00:00:54,140
+وازدادت شهرتها بعد سنتين عند ظهور نوع الـ
+
+9
+00:00:54,140 --> 00:00:58,420
+Middle East Respiratory Syndrome هو الـ MERS Coronavirus
+
+10
+00:00:58,420 --> 00:01:05,120
+في الخليج العربي اللي هي واحدة من أهم مسببات الـ
+
+11
+00:01:05,120 --> 00:01:09,480
+Common Cold يعني تالية في الأهمية الـ Rhinovirus
+
+12
+00:01:09,480 --> 00:01:12,760
+وزمان ما ذكرنا لكم في 2002 تم اكتشاف اللي هو
+
+13
+00:01:12,760 --> 00:01:18,260
+Atypical Pneumonia بفيروس لما شرحنا الفيروس
+
+14
+00:01:18,260 --> 00:01:24,770
+ودرسناه لجينا هو Coronavirus شكلًا و تركيبًا لكن الـ
+
+15
+00:01:24,770 --> 00:01:27,870
+Sequence Analysis زي ما ذكرنا في المحاضرة السابقة
+
+16
+00:01:27,870 --> 00:01:32,630
+الـ Sequence Analysis للـ DNA للـ Coronavirus لجينة
+
+17
+00:01:32,630 --> 00:01:36,490
+مختلفة عن الـ Other .. عفوا للـ SARS لجينة مختلفة عن
+
+18
+00:01:36,490 --> 00:01:39,810
+الـ Other Coronavirus لكن الـ Isolates of
+
+19
+00:01:39,810 --> 00:01:44,990
+Coronaviruses أعطتنا Similar Sequence أو DNA
+
+20
+00:01:44,990 --> 00:01:49,730
+Sequence هذا مؤشر على إيه؟ على أن التركيب تبع الـ
+
+21
+00:01:49,730 --> 00:01:53,590
+.. ال .. ال .. الـ SARS Viruses أو Strains شبيه
+
+22
+00:01:53,590 --> 00:01:58,690
+وبالتالي التوقع كان أن الـ Antigen تبعهم يكون واحد
+
+23
+00:01:58,690 --> 00:02:02,750
+ويكون Stable كمان يكون Stable زي ما ذكرنا في أحد
+
+24
+00:02:02,750 --> 00:02:10,230
+اللوحات نعمانا عندي لأن الـ Corona Viruses واحد منهم
+
+25
+00:02:10,230 --> 00:02:15,370
+اكتشفناه جديد اسمه SARS شكلًا ومضمونًا بيشبه بيشبه
+
+26
+00:02:15,370 --> 00:02:18,210
+الـ Other Corona Viruses تمام؟ لكن لما عملنا
+
+27
+00:02:18,210 --> 00:02:21,370
+Sequence Analysis للـ SARS Virus اللي جدًا بيختلف
+
+28
+00:02:21,370 --> 00:02:25,550
+بشكل كبير عن اللي هو مين؟ عن الـ Other Corona Virus
+
+29
+00:02:25,550 --> 00:02:30,420
+لأن الـ SARS برضه أنا عزل منه أكثر من عزلة لما جينا
+
+30
+00:02:30,420 --> 00:02:33,540
+عملنا Sequence Analysis للـ SARS المختلفة لجيناهم
+
+31
+00:02:33,540 --> 00:02:36,980
+بيشبهوا بعض إلى حد كبير فتوقعنا أن يكون الـ Antigen
+
+32
+00:02:36,980 --> 00:02:40,980
+تبعهم أن يكون One ويكون Stable هذا الـ Antigen هذا
+
+33
+00:02:40,980 --> 00:02:45,780
+الفكرة كانت فيه اللي هو الحديث تبعنا من المميزات
+
+34
+00:02:45,780 --> 00:02:48,340
+للـ Corona فيها تقولنا اللي هو الـ Club Shape Spikes
+
+35
+00:02:48,340 --> 00:02:50,740
+اللي الكبيرة هذه اللي شايفينها تبعها و الشكل
+
+36
+00:02:50,740 --> 00:02:56,850
+الجميل اللي أعطاها شكل اللي هو الـ Corona وزي
+
+37
+00:02:56,850 --> 00:02:59,490
+الآخرين اللي تحدثنا عنه أن هو بينتقل عبر اللي هو الـ
+
+38
+00:02:59,490 --> 00:03:03,170
+Respiratory To Aerosols و الـ Infection Can Occur
+
+39
+00:03:03,170 --> 00:03:06,170
+Worldwide أنا دلوقتي أخذوا بالكم في الـ .. في الـ
+
+40
+00:03:06,170 --> 00:03:09,470
+Chapter هذا فيه هيصير فيه Mixed Up شوية مرة أتكلم
+
+41
+00:03:09,470 --> 00:03:13,690
+عن الـ SARS بخصوص .. بخصوصية و مرة أتكلم عن مين؟ عن
+
+42
+00:03:13,690 --> 00:03:17,050
+الـ Coronavirus عندما أنا أتكلم عن الـ SARS هنقول
+
+43
+00:03:17,050 --> 00:03:19,970
+أنهم أتكلم عن الـ SARS بس في الواقع الحديث معاهم
+
+44
+00:03:19,970 --> 00:03:23,250
+يقولوا حول مين؟ حول اللي هو الـ Coronavirus خاصة في
+
+45
+00:03:23,250 --> 00:03:27,750
+الـ Characteristics العامة اللي منذ قرن ونصف أو
+
+46
+00:03:27,750 --> 00:03:32,270
+أكثر من نصف الأطفال أصيبوا بالـ Coronavirus و اللي
+
+47
+00:03:32,270 --> 00:03:35,350
+أقصد فيها الـ SARS تمام؟ الـ Coronavirus اللي بتسبب
+
+48
+00:03:35,350 --> 00:03:38,950
+الرشح اللي حكينا عنه الـ Outbreaks كنا بتحدث من
+
+49
+00:03:38,950 --> 00:03:44,260
+سنتين إلى ثلاث سنوات مش كل سنة زي مين؟ كل سنة الـ
+
+50
+00:03:44,260 --> 00:03:47,080
+Respiratory Syncytial و الـ Respiratory Syncytial
+
+51
+00:03:47,080 --> 00:03:54,420
+Virus و ذكرنا التفسير العلمي لماذا هناك فترات
+
+52
+00:03:54,420 --> 00:04:00,120
+زمانية بين حدوث الأوبئة لنفس الميكروب مثلًا هنشوف
+
+53
+00:04:00,120 --> 00:04:05,840
+كمان شوية ميكروب كل ستة لتسع سنوات بيعمل Cycle من
+
+54
+00:04:05,840 --> 00:04:10,190
+Outbreaks الـ Number of Children أو الـ Number of
+
+55
+00:04:10,190 --> 00:04:13,530
+Susceptible Population لازم يكون Enough for this
+
+56
+00:04:13,530 --> 00:04:18,500
+Virus To Produce Outbreak في الـ .. في الـ
+
+57
+00:04:18,500 --> 00:04:22,060
+Respiratory Syncytial Virus كانت سنوية صح؟ هذا
+
+58
+00:04:22,060 --> 00:04:25,520
+معناه يحكي إن الـ Immunity Completely Incomplete
+
+59
+00:04:25,520 --> 00:04:30,620
+يعني هي أصلًا مش ثابتة وبالتالي كل سنة معرض إن
+
+60
+00:04:30,620 --> 00:04:35,200
+الناس ينصبوا هذا الـ Virus لكن لو ينصبوا بالربلة،
+
+61
+00:04:35,200 --> 00:04:39,910
+حيصير فيه إنديواباة، القفار ممكن تموت أطفال كثيرة
+
+62
+00:04:39,910 --> 00:04:44,610
+هينجو ويكونوا مناعة السنة الجاية لو الفيروس اجا
+
+63
+00:04:44,610 --> 00:04:50,290
+نسبة الأعظم من الأطفال عندهم مناعة فبفكرة الـ Herd
+
+64
+00:04:50,290 --> 00:04:54,310
+Immunity أو الـ Community Immunity لن يستطيع الربلة
+
+65
+00:04:54,310 --> 00:04:58,830
+أن يعمل وباء إلا بعد مرور فترة من الزمن وظهور
+
+66
+00:04:58,830 --> 00:05:03,350
+أطفال جدد بكمية كافية لحدوث اللي هو الوباء أرجو
+
+67
+00:05:03,350 --> 00:05:07,030
+أن هذه النقطة تكون خلاص يعني اختمرت فيها أقول لكم أن
+
+68
+00:05:07,030 --> 00:05:13,220
+شاء الله الـ SARS Originated In China في الصين في
+
+69
+00:05:13,220 --> 00:05:21,560
+نوفمبر 2002 وانتقل بشكل سريع إلى بلدان أخرى عندما
+
+70
+00:05:21,560 --> 00:05:26,920
+كنت بهذه الشرائح كان عدد حالات المصابة حوالي 9000
+
+71
+00:05:26,920 --> 00:05:33,280
+ومات منهم حوالي 800 بنسبة 13% Mortality Rate أعتقد
+
+72
+00:05:33,280 --> 00:05:37,640
+أن 13% Mortality Rate هذا رقم خطير ولا لا؟ يعني من
+
+73
+00:05:37,640 --> 00:05:41,540
+كل 100 شخص 13 واحد بدا يموت هذا رقم بالفعل بيكون
+
+74
+00:05:41,540 --> 00:05:45,900
+صعب للغاية الـ Transmission And Epidemiology
+
+75
+00:05:45,900 --> 00:05:50,720
+الانتقال أول ما صار انتقال في المستشفيات يعني
+
+76
+00:05:50,720 --> 00:05:55,220
+المريض اللي إجا مصاب نقل لمين؟ للـ Health Care
+
+77
+00:05:55,220 --> 00:06:01,360
+Workers واعتقدوا أنه حتى أن الناس المصابين في منهم
+
+78
+00:06:01,360 --> 00:06:05,110
+مجموعة بسموهم Super Spreader إيش يعني Super
+
+79
+00:06:05,110 --> 00:06:10,790
+Spreader؟ يعني وجود الفيروس في هذا الإنسان بيجعل
+
+80
+00:06:10,790 --> 00:06:14,630
+هذا الإنسان قادر على نقله إلى عدد كبير جدا من مين؟
+
+81
+00:06:14,630 --> 00:06:18,730
+من الناس الآخرين، فبيسموهم Super Spreader لكن هذا
+
+82
+00:06:18,730 --> 00:06:23,930
+المصطلح Yet To Be Confirmed لحد الآن لم يثبت علميًا
+
+83
+00:06:23,930 --> 00:06:27,490
+أن فيه أفراد اسمها Super Spreader لكن كان فيه
+
+84
+00:06:27,490 --> 00:06:31,930
+Prediction أو تنبؤات أن ممكن يكون Super Spreader
+
+85
+00:06:31,930 --> 00:06:35,570
+التنبؤات هي بناء على إيه؟ بناء على ما رأوا من
+
+86
+00:06:35,570 --> 00:06:39,710
+الملاحظات وانتشار سريع في بعض الأماكن اللي زي
+
+87
+00:06:39,710 --> 00:06:46,370
+المستشفيات طب كيف اتخلصنا من جثة المستشفيات أن
+
+88
+00:06:46,370 --> 00:06:49,360
+يسبب انتقال؟ فيه أفراد اسم يا بنات؟ Infection
+
+89
+00:06:49,360 --> 00:06:54,140
+Control Measures، إجراءات اللي هو منع العدوى، الآن
+
+90
+00:06:54,140 --> 00:06:58,280
+إجراءات منع العدوى مصطلح عام لها، مصطلح عام،
+
+91
+00:06:58,280 --> 00:07:02,560
+العدوى قد تكون عبر الجلد، قد تكون عبر الإبر، عبر
+
+92
+00:07:02,560 --> 00:07:07,020
+الشاربس، طب لما تكون عبر الـ Respiratory، فيه إلها
+
+93
+00:07:07,020 --> 00:07:11,030
+إجراءات خاصة فاحنا لو كان في مرض بينتقل عن طريق
+
+94
+00:07:11,030 --> 00:07:15,470
+الجهاز التنفسي، بنقول يلا ابدأوا تطبقوا إجراءات
+
+95
+00:07:15,470 --> 00:07:18,950
+منع العدوى المتعلقة بمين؟ بأمراض الجهاز التنفسي،
+
+96
+00:07:18,950 --> 00:07:23,450
+وفي الحقيقة أنه جابت نتيجة وقللت نسب الإصابة في
+
+97
+00:07:23,450 --> 00:07:26,070
+العاملين في القطاع الصحي اللي بيتعاملوا مع مرضى
+
+98
+00:07:26,070 --> 00:07:32,540
+الـ SARS الآن في عندي نقطة ثانية أن فيه Animal
+
+99
+00:07:32,540 --> 00:07:36,220
+Reservoir Animal Reservoir إيش يعني Animal
+
+100
+00:07:36,220 --> 00:07:40,300
+Reservoir؟ يعني فيه مخازن حيوانية للـ Coronavirus
+
+101
+00:07:40,300 --> 00:07:45,060
+ويعتقد أن لها دور كبير في انتقالها لمين؟ للإنسان
+
+102
+00:07:45,060 --> 00:07:50,340
+في حيوانين اثنين رئيسي الخفاش الذي يشبه حدوة
+
+103
+00:07:50,340 --> 00:07:55,070
+الحصان بسموه Horse أو Shoe Horse مش عارف Horse Shoe
+
+104
+00:07:55,070 --> 00:07:59,470
+Horse Shoe اللي هو حدوة الحصان بقت هذا كـ Reservoir
+
+105
+00:07:59,470 --> 00:08:04,330
+Natural Reservoir وفيه حيوان Civet Cat قطة الـ
+
+106
+00:08:04,330 --> 00:08:09,410
+Civet طبعًا هذه القطة تؤكل من قبل الصينيين يعني
+
+107
+00:08:09,410 --> 00:08:13,250
+بيبيعوها في الأسواق و بيأكلوها الصينيين فبيعتقدوا
+
+108
+00:08:13,250 --> 00:08:16,430
+أنها Intermediate Host Intermediate Host يعني هي
+
+109
+00:08:16,430 --> 00:08:22,200
+اللي بتنقل معظم الحالات اللي أصيبت Originally مش
+
+110
+00:08:22,200 --> 00:08:25,820
+اللي هم موردين من الأطباء كانت أصيبت من من من
+
+111
+00:08:25,820 --> 00:08:30,000
+تناولهم أو تعاملهم مع من؟ مع الـ Cats مش مع الخفافيش
+
+112
+00:08:30,000 --> 00:08:35,220
+وإنما مع هذا النوع من القطط الـ Coronavirus
+
+113
+00:08:35,220 --> 00:08:39,140
+Infection Is Typically Limited To Mucosal Cells Of
+
+114
+00:08:39,140 --> 00:08:43,240
+The Respiratory Tract يعني بتخترقش إلى أماكن أخرى
+
+115
+00:08:43,240 --> 00:08:48,890
+فقط بتكون في الـ Mucosal Cells حوالي خمسين بالمائة من
+
+116
+00:08:48,890 --> 00:08:53,350
+نسب الإصابة أو من الإصابة بتكون Asymptomatic وكلمة
+
+117
+00:08:53,350 --> 00:08:57,510
+Asymptomatic يعني إيه؟ يعني ما فيش أعراض وأنا وأنا
+
+118
+00:08:57,510 --> 00:09:03,910
+سؤال هل لهؤلاء الـ Asymptomatic Patients دور في نقل
+
+119
+00:09:03,910 --> 00:09:09,270
+المرض ولا ما لهمش دور؟ أنتوا على طول قلتوا آه يعني و
+
+120
+00:09:09,270 --> 00:09:11,970
+احنا قاعدين بقول لكم أن العالم بيقول It Is Unclear
+
+121
+00:09:11,970 --> 00:09:15,310
+يعني ليس من الواضح وأنتوا على طول قفزتوا أن إيه
+
+122
+00:09:15,310 --> 00:09:18,590
+مع أن أنا حذرتكم المحاضرة الماضية وقلت لكم يا
+
+123
+00:09:18,590 --> 00:09:23,970
+جماعة لغة الـ Science دائمًا مشككة مشككة وليست
+
+124
+00:09:23,970 --> 00:09:28,150
+قاطعة بس أنتوا طبعًا تحبوا تقطعوا الشك باليقين
+
+125
+00:09:32,480 --> 00:09:35,320
+يعني حتى لما بنعمل في فيسبوك يا Like يا Dislike، 
+
+126
+00:09:35,320 --> 00:09:40,180
+مافيش حلول وسط عنها، immunity following infection
+
+127
+00:09:40,180 --> 00:09:45,360
+appears to be brief، brief معناها قصيرة، يعني
+
+128
+00:09:45,360 --> 00:09:48,480
+المناعة اللي بنحصل عليها بعد العدوى بتكون قصيرة،
+
+129
+00:09:48,480 --> 00:09:52,600
+لذلك multiple infection can occur، يعني بنقدر نصاب
+
+130
+00:09:52,600 --> 00:09:55,660
+بالـ coronavirus مرارا وتكرار
+
+131
+00:09:59,210 --> 00:10:07,090
+السبب السيئ بالوفيات فيه غالبا الغرق،
+
+132
+00:10:07,090 --> 00:10:12,990
+ماهو رأيكم؟ الإنسان كيف بيغرق؟ بأنقطاع عن الأكسجين،
+
+133
+00:10:12,990 --> 00:10:17,030
+مظبوط؟ طبعا لو .. لو .. لو انقطع الـ oxygen بالـ
+
+134
+00:10:17,030 --> 00:10:21,230
+بالخنق، لكن هذا لا يخنق، وإنما السوائل will build
+
+135
+00:10:21,230 --> 00:10:25,050
+up in the lungs، فبالتالي هو ما ينخنقش، هو غرق
+
+136
+00:10:25,050 --> 00:10:28,210
+بالفعل، غرق في اللي هو السوائل اللي موجودة في الـ
+
+137
+00:10:28,210 --> 00:10:31,970
+lungs تبعته، وبالتالي صار عنده hypoxia أو نقص في 
+
+138
+00:10:31,970 --> 00:10:36,840
+الـ oxygen وبالتالي ممكن يموت الـ Clinical finding
+
+139
+00:10:36,840 --> 00:10:39,680
+هو الـ common cold caused by Corona virus is
+
+140
+00:10:39,680 --> 00:10:42,200
+characterized by Coryza Coryza اللي هي الـ runny
+
+141
+00:10:42,200 --> 00:10:46,940
+nose زي ما حكينا، scratchy sore throat، بيكون
+
+142
+00:10:46,940 --> 00:10:51,340
+المريض بيحاول يحكّ حلقّه من جوا، ليش؟ لأنه في
+
+143
+00:10:51,340 --> 00:10:54,690
+شعور بالتنميل تماما والحكة في الـ sore throat وعلى
+
+144
+00:10:54,690 --> 00:11:00,190
+فكرة هذا common بين الناس وللأسف بياخدوا 
+
+145
+00:11:00,190 --> 00:11:03,990
+antibiotic برضه لعلاج هذا النوع من الـ sore throat
+
+146
+00:11:03,990 --> 00:11:09,330
+وهو لا يحتاج وغالبا هتشوفوا أن الـ coronavirus are
+
+147
+00:11:09,330 --> 00:11:13,570
+self-limited ومافيش أي يعني consequences أو 
+
+148
+00:11:13,570 --> 00:11:16,590
+complications للـ disease غالبا self-limited بتروح
+
+149
+00:11:16,590 --> 00:11:25,890
+لحالها بدون أي أعراض جانبية الصحيحة تبقى مجموعة
+
+150
+00:11:25,890 --> 00:11:31,470
+أيام وليس لديها
+
+151
+00:11:31,470 --> 00:11:36,830
+آثار طويلة على المدى البعيد كورونا فايروس أيضا يسبب
+
+152
+00:11:36,830 --> 00:11:42,230
+برونكايتس،  bronchitis هو نيومونيا عادية وذكرنا عنه قبل
+
+153
+00:11:42,230 --> 00:11:48,090
+قليل ومخصص من حرارة 38 درجة مئوية  Non-productive
+
+154
+00:11:48,090 --> 00:11:51,950
+cough مش هي non-productive cough يعني كحة ما بيطلع
+
+155
+00:11:51,950 --> 00:11:55,470
+فيها المريض Sputum تمام؟ بينما الـ productive cough
+
+156
+00:11:55,470 --> 00:11:59,870
+بتكون كحة جافة يعني زي dry cough، dyspnea اختناق
+
+157
+00:11:59,870 --> 00:12:03,690
+and هيبوكسيا أو قلنا هيبوكسيا نتجت عن الـ
+
+158
+00:12:03,690 --> 00:12:06,790
+accumulation لمين؟ للـ fluid في الـ lungs
+
+159
+00:12:09,510 --> 00:12:13,490
+اللي أنا ما زلت في الفقرة التالية أتحدث عن مين؟ عن
+
+160
+00:12:13,490 --> 00:12:17,710
+الـ SARS، chills, rigors, malaise and headache
+
+161
+00:12:17,710 --> 00:12:23,370
+commonly occur، but sore throat and rhinorrhea are
+
+162
+00:12:23,370 --> 00:12:27,170
+uncommon، يعني إن يكون فيه runny nose وإن يكون فيه
+
+163
+00:12:27,170 --> 00:12:30,070
+التهيبات في الحلق، بتكونش common في مين؟ في الـ
+
+164
+00:12:30,070 --> 00:12:34,490
+SARS، الـ SARS أكتر شكل للنيومونيا، بينما الـ other
+
+165
+00:12:34,490 --> 00:12:37,690
+coronavirus بتكون upper respiratory tract
+
+166
+00:12:37,690 --> 00:12:41,040
+infection في الـ SARS أيضًا بيكون في  Lymphopenia
+
+167
+00:12:41,040 --> 00:12:43,560
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+168
+00:12:43,560 --> 00:12:43,620
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+169
+00:12:43,620 --> 00:12:44,640
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+170
+00:12:44,640 --> 00:12:44,760
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+171
+00:12:44,760 --> 00:12:44,800
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+172
+00:12:44,800 --> 00:12:44,860
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+173
+00:12:44,860 --> 00:12:45,020
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+174
+00:12:45,020 --> 00:12:45,480
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+175
+00:12:45,480 --> 00:12:49,380
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+176
+00:12:49,380 --> 00:12:53,260
+و .. و
+
+177
+00:12:53,260 --> 00:12:55,980
+.. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+178
+00:13:04,260 --> 00:13:07,840
+وقت محدد، تلات أيام، أربع أيام، خمس أيام، ما عنديش
+
+179
+00:13:07,840 --> 00:13:14,940
+بنقول ده من الـ range بس الجرعة
+
+180
+00:13:14,940 --> 00:13:18,740
+اللي هي الـ dose بالإضافة إلى مين؟ إلى اللي هو الـ
+
+181
+00:13:18,740 --> 00:13:22,660
+immunity وهل أصلا في previous contact مع الـ virus
+
+182
+00:13:22,660 --> 00:13:25,340
+ولا ما فيش previous contact مع الـ virus؟ هذا فيه
+
+183
+00:13:25,340 --> 00:13:28,780
+كثير من الأحيان، لكن في أحيان أخرى الأمر مرتبط
+
+184
+00:13:28,780 --> 00:13:33,560
+ممكن يكون بعامل آخر، مثل الـ rabies اللي هنتحدث عنه
+
+185
+00:13:33,560 --> 00:13:40,400
+لاحقا في هذا الفصل أيضًا الـ incubation period وظهور
+
+186
+00:13:40,400 --> 00:13:46,640
+الأعراض الرئيسية مرتبط ببعد العضة بتاعة الكلب أو
+
+187
+00:13:46,640 --> 00:13:51,200
+الخفاش أو whatsoever أو النمر تخيلوا نمر عشان
+
+188
+00:13:51,200 --> 00:13:52,280
+يعمل له rabies
+
+189
+00:13:54,910 --> 00:13:59,230
+بعد عن الجهاز العصبي المركزي لما بتكون العضة بيكون
+
+190
+00:13:59,230 --> 00:14:03,310
+فيه فترة incubation قصيرة يعني لو كانت العضة في
+
+191
+00:14:03,310 --> 00:14:06,390
+مكان في الرقبة أو في الكتف أو في مكان في الرأس
+
+192
+00:14:06,390 --> 00:14:11,210
+بتكون بسرعة تحدث اللي هو الأعراض تدهور بسرعة لكن
+
+193
+00:14:11,210 --> 00:14:16,050
+لو كانت بعيدة مثلًا في الساق هذا بيعطي فترة أطول للـ
+
+194
+00:14:16,050 --> 00:14:18,470
+incubation period إذا الـ incubation period في
+
+195
+00:14:18,470 --> 00:14:21,750
+مجموعة عوامل اللي قد تؤثر عليها نوع الـ microbe
+
+196
+00:14:22,360 --> 00:14:25,260
+الـ microbe بتاعي فيه اختلافات فيه شيء 7 على 10 أيام
+
+197
+00:14:25,260 --> 00:14:31,460
+فيه 10 على 24 فيه يومين تمام زي الـ influenza زي
+
+198
+00:14:31,460 --> 00:14:35,580
+الرشح يعني الـ incubation period معتمدة على واحد
+
+199
+00:14:35,580 --> 00:14:39,440
+نوع الـ microbe اثنين الجرعة ثلاثة المناعة الـ site
+
+200
+00:14:39,440 --> 00:14:44,060
+of entry مكان دخول اللي هو الـ virus أو الـ microbe
+
+201
+00:14:47,130 --> 00:14:49,710
+الـ diagnosis of the common cold is made clinically،
+
+202
+00:14:49,710 --> 00:14:52,410
+وللأسف ما أستطيع بالـ clinical diagnosis أنني
+
+203
+00:14:52,410 --> 00:14:54,990
+أتميز أن هذا رينوفيروس ولا كورونافيروس ولا 
+
+204
+00:14:54,990 --> 00:14:58,930
+أدينوفيروس ولا رسبراتوريس انسيتيل ولا بعرع
+
+205
+00:14:58,930 --> 00:15:01,650
+انفلوانذافارات، ما أقدرش أنني أتميز بينهم، ولكن بنقول
+
+206
+00:15:01,650 --> 00:15:07,370
+common cold لاحظوا الـ common cold كلهم self-limited
+
+207
+00:15:07,370 --> 00:15:10,910
+ولا واحد من اللي احنا درسناهم في بيعمل ايه له
+
+208
+00:15:10,910 --> 00:15:14,410
+complications وبالتالي بس لو احنا قلنا common cold
+
+209
+00:15:14,410 --> 00:15:19,110
+وشخصنا صح انتهى الموضوع سواء راحة انتهى أو انتهت
+
+210
+00:15:19,110 --> 00:15:23,810
+الجثة في هذا الموضوع لكن إذا SARS لا نكتفي بالـ
+
+211
+00:15:23,810 --> 00:15:26,930
+clinical diagnosis لازم يكون فيه إنّه antibody
+
+212
+00:15:26,930 --> 00:15:33,830
+based test أو PCR based test بالتعليم والتحقيق، لا
+
+213
+00:15:33,830 --> 00:15:38,210
+يوجد
+
+214
+00:15:38,210 --> 00:15:44,950
+علاج أو تطييب لهذا الفيروس، لكن في محاولة أجريت
+
+215
+00:15:44,950 --> 00:15:48,210
+باستخدام الـ ribavirin، و ribavirin هيّ مرّت معانا كتير
+
+216
+00:15:48,210 --> 00:15:53,090
+في هذا الفصل أو في هذا الـ chapter يعني أقصد،
+
+217
+00:15:53,090 --> 00:15:56,590
+الـ ribavirin بالإضافة إلى الـ steroids كانوا يحاولوا
+
+218
+00:15:56,590 --> 00:16:03,290
+في التعليم للحالات  Life-threatening cases يعني حالات
+
+219
+00:16:03,290 --> 00:16:09,170
+مهددة للحياة و بالتالي المحاولة بأي شيء قد يعني
+
+220
+00:16:09,170 --> 00:16:15,210
+تساعد but their efficacy is uncertain للجماعة اللي
+
+221
+00:16:15,210 --> 00:16:20,510
+على طول بيفترضوا إنّ أو لا احنا كل مرة بنقول لكم على
+
+222
+00:16:20,510 --> 00:16:25,190
+الرغم من المحاولات إنّه مش قادرين نحدد هل بالفعل الـ
+
+223
+00:16:25,190 --> 00:16:29,180
+effectiveness تبعها عالية ولا منخفضة هل في المستقبل
+
+224
+00:16:29,180 --> 00:16:33,240
+نعتمد هذا النوع من العلاج ولا لا؟ ليش الـ
+
+225
+00:16:33,240 --> 00:16:37,460
+uncertainty موجودة؟ هل احنا بنحب إنّه دائما نكون
+
+226
+00:16:37,460 --> 00:16:43,520
+مشككين؟ ما بنحبش نكون مشككين، لكن عدد المرضى اللي
+
+227
+00:16:43,520 --> 00:16:46,780
+تعاملنا معاهم على سبيل المثال بيكون قليل الـ
+
+228
+00:16:46,780 --> 00:16:50,760
+outcome اللي طلعت الـ percentage اللي طلعت شيء منهم
+
+229
+00:16:50,760 --> 00:16:54,220
+أكثر من 10 بالمية okay أكثر من 30 بالمية مش okay
+
+230
+00:16:54,220 --> 00:16:58,120
+يعني بمعنى بمعنى آخر إنّه مش قادر أحصل على نتيجة
+
+231
+00:16:58,120 --> 00:17:02,140
+conclusive حاسمة تقول إن والله هذا treatment is
+
+232
+00:17:02,140 --> 00:17:05,990
+effective وبيكونوا بيتذكروا أن أيّ steroid تُعطى
+
+233
+00:17:05,990 --> 00:17:08,950
+للإنسان لازم تُعطى بحدها، لأنّ احنا أصلا مش
+
+234
+00:17:08,950 --> 00:17:13,090
+فاهمين بالضبط كيف الـ steroid بتشتغل، بتعمل عاصفة في
+
+235
+00:17:13,090 --> 00:17:20,230
+الجسم، وبيستفيد الجسم في بعض الأحيان لكن دائما و
+
+236
+00:17:20,230 --> 00:17:25,210
+أبدًا هناك مضار من استخدام الـ steroid تمام؟ فبرضه
+
+237
+00:17:25,210 --> 00:17:30,130
+مش لازم نستخدم الـ steroid إلا بحذر و under control
+
+238
+00:17:30,130 --> 00:17:34,350
+لازم يكون الأطباء موجودين و يشوفوا إيش ممكن يصير
+
+239
+00:17:34,350 --> 00:17:39,770
+فيه مضاعفة للفيروس التالي في السلسلة خلصنا كورونا
+
+240
+00:17:39,770 --> 00:17:43,270
+فيروس الآن نتكلم عالميا عن روبيلا لحظة روبيلا
+
+241
+00:17:43,270 --> 00:17:48,220
+ارتبط اسمه بالـ measles و بالـ mumps صح؟ الـ measles
+
+242
+00:17:48,220 --> 00:17:54,540
+و الـ mumps بينتموا لمين؟ للـ paramyxovirus هذا ما له علاقة
+
+243
+00:17:54,540 --> 00:17:58,080
+.. هذا ما له علاقة فيهم على الرغم من أنهم الثلاث
+
+244
+00:17:58,080 --> 00:18:03,920
+مالهم في نفس الـ vaccine ولاحظوا disease measles و
+
+245
+00:18:03,920 --> 00:18:08,420
+german measles وكلاهما .. كلاهما بيحدثوا تقريبًا
+
+246
+00:18:08,420 --> 00:18:13,400
+نفس المرض لكن بينتموا إلى عائلات وتركيبات مختلفة
+
+247
+00:18:13,400 --> 00:18:18,580
+الـ paramyxovirus فيروسات negative sense RNA هذا
+
+248
+00:18:18,580 --> 00:18:23,020
+positive sense RNA نعم، فيروس بيختلف تمامًا عن الـ
+
+249
+00:18:23,020 --> 00:18:27,480
+Paramyxovirus هادول كانوا helical هادي
+
+250
+00:18:27,480 --> 00:18:32,580
+eicosahedral إذا في اختلاف بينهم على الرغم من أنهم 
+
+251
+00:18:32,580 --> 00:18:37,610
+بيسببوا تقريبا أمراض شبيهة ببعضها البعض الفيروس يسبب
+
+252
+00:18:37,610 --> 00:18:41,470
+فيه تجارات تجارات تجارات تجارات تجارات
+
+253
+00:18:41,470 --> 00:18:42,990
+تجارات تجارات تجارات تجارات تجارات تجارات
+
+254
+00:18:42,990 --> 00:18:44,630
+تجارات تجارات تجارات تجارات تجارات تجارات
+
+255
+00:18:44,630 --> 00:18:48,450
+تجارات تجارات تجارات تجارات
+
+256
+00:18:48,450 --> 00:18:50,250
+تجارات تجارات تجارات تجارات تجارات تجارات
+
+257
+00:18:50,250 --> 00:18:50,310
+تجارات تجارات تجارات تجارات تجارات تجارات
+
+258
+00:18:50,310 --> 00:18:50,710
+تجارات تجارات تجارات تجارات تجارات تجارات
+
+259
+00:18:50,710 --> 00:18:55,310
+تجارات تجارات تجارات 
+
+260
+00:18:55,310 --> 00:18:56,190
+تجارات
+
+261
+00:19:00,790 --> 00:19:04,250
+Cytomegalovirus الآن إذا بتذكروا الجملة إيش بتقول
+
+262
+00:19:04,250 --> 00:19:08,830
+أن الـ CMV في اللي درسناها بتقول أن الـ CMV is one
+
+263
+00:19:08,830 --> 00:19:12,790
+of the leading causes of congenital abnormality in
+
+264
+00:19:12,790 --> 00:19:15,710
+the United States فمهما بيعمل congenital
+
+265
+00:19:15,710 --> 00:19:20,530
+abnormality تذكروا أن الـ CMV ما يوجدوش vaccine هذا
+
+266
+00:19:20,530 --> 00:19:23,530
+الـ vaccine الـ vaccine عمل reduction
+
+267
+00:19:26,140 --> 00:19:30,420
+لحالات الحصبة بشكل عام وبالتالي عمل reduction
+
+268
+00:19:30,420 --> 00:19:34,020
+لحالات أيضًا الـ congenital rubella إذا احنا خفضنا
+
+269
+00:19:34,020 --> 00:19:37,080
+الربلة العادية وبالتالي خفضنا أيضًا مين اللي هو الـ
+
+270
+00:19:37,080 --> 00:19:42,120
+congenital abnormal ال
+
+271
+00:19:42,120 --> 00:19:45,100
+characteristics بتاعة الفيروس هنا toga virus قلنا
+
+272
+00:19:45,100 --> 00:19:51,620
+هو مش بعلم يكسي ولا كورونا هو toga virus one piece
+
+273
+00:19:51,620 --> 00:19:56,100
+of a single-stranded RNA icosahedral nucleocapsid
+
+274
+00:19:56,100 --> 00:19:58,660
+and a lipoprotein envelope يعني برضه still
+
+275
+00:19:58,660 --> 00:20:01,980
+envelope لإن احنا أصلاً عنوانها ما تنسوش RNA
+
+276
+00:20:01,980 --> 00:20:08,340
+enveloped virus على النقيض الـ paramyxoviruses
+
+277
+00:20:08,340 --> 00:20:12,280
+زي الميسلز والمَمْس اللي هم إخوته في الـ vaccine مش
+
+278
+00:20:12,280 --> 00:20:17,110
+في الرضاعة إخوته في الـ vaccine it has a positive
+
+279
+00:20:17,110 --> 00:20:20,510
+-stranded RNA، يعني مع الحاجة اللوتانية شمالهم،
+
+280
+00:20:20,510 --> 00:20:24,510
+negative-stranded RNA، and therefore it has no
+
+281
+00:20:24,510 --> 00:20:29,110
+virion polymerase، بينما الميسلز والمامس كانوا
+
+282
+00:20:29,110 --> 00:20:32,630
+بيحتاجوا RNA dependent، RNA polymerase يكون معاهم
+
+283
+00:20:32,630 --> 00:20:37,360
+في الـ virus particle الـ spikes بتحتوي على
+
+284
+00:20:37,360 --> 00:20:42,680
+hemagglutinin، single antigenic type، سر نجاحنا في
+
+285
+00:20:42,680 --> 00:20:46,960
+الفاكسين، أن one single serotype وأن الـ human are
+
+286
+00:20:46,960 --> 00:20:52,480
+the only natural host for this virus، و الـ
+
+287
+00:20:52,480 --> 00:20:56,580
+antibody directed against hemagglutinin
+
+288
+00:20:56,580 --> 00:21:00,560
+neutralizes infectivity، وأنا بالدجاج عندها دي
+
+289
+00:21:00,560 --> 00:21:09,700
+نقطة نظام neutralizes infectivity ما بتعني لكم أن
+
+290
+00:21:09,700 --> 00:21:14,880
+الفيروس هي عنده hemagglutinin إذا الانتيبادرتبط
+
+291
+00:21:14,880 --> 00:21:20,260
+فيه منعه أنه يعمل infection للخلايا ممتاز قليلة
+
+292
+00:21:20,260 --> 00:21:25,860
+عمره جيد في كل مرة وأن في مرة ما كانش جيد
+
+293
+00:21:29,790 --> 00:21:33,770
+في الـ respiratory syncytial virus فاكرين؟ المرض
+
+294
+00:21:33,770 --> 00:21:37,430
+أصلًا كان ناتج عن مين؟ عن ارتباط على الرغم من أنه
+
+295
+00:21:37,430 --> 00:21:41,650
+بالفعل الـ antibody عمل neutralizers للـ infectivity
+
+296
+00:21:41,650 --> 00:21:45,930
+of the virus لكن الـ disease كان ناتج عن الارتباط
+
+297
+00:21:45,930 --> 00:21:48,690
+هذا لأنه عمل activation للـ complement عمل
+
+298
+00:21:48,690 --> 00:21:52,890
+destruction للـ lungs cells جمعت الـ immune system
+
+299
+00:21:52,890 --> 00:21:57,370
+برضه عمل destruction إضافي للـ lungs إذا كلمة
+
+300
+00:21:57,370 --> 00:22:02,930
+neutralizes infectivity معناها واحد بأن الفيروس لم
+
+301
+00:22:02,930 --> 00:22:09,750
+يعد قادرًا على إصابة الخلايا ومن ثم تكاثر لكن هذا
+
+302
+00:22:09,750 --> 00:22:14,110
+لا يعني أنه بالضرورة أنه .. أنه كويس، عايشوفنا مرة
+
+303
+00:22:14,110 --> 00:22:18,030
+كويس في هذه الحالة تمام؟ ومرة مش كويس في حالة مين؟
+
+304
+00:22:18,030 --> 00:22:19,970
+الـ respiratory syncytial virus
+
+305
+00:22:24,190 --> 00:22:27,710
+The virus is transmitted via respiratory droplets
+
+306
+00:22:27,710 --> 00:22:31,550
+كل يوم جاعدين نتأكد .. نتأكد و بنأكد الحقيقة اللي
+
+307
+00:22:31,550 --> 00:22:36,710
+ذكرناها أن الـ enveloped viruses تنار غالبًا فيروسات
+
+308
+00:22:36,710 --> 00:22:40,130
+حساسة و بدها close contact و غالبًا الـ respiratory
+
+309
+00:22:40,130 --> 00:22:44,250
+أو sexual contact هو الـ mean of الـ transmission أو
+
+310
+00:22:44,250 --> 00:22:45,830
+الـ direct transmission
+
+311
+00:22:47,950 --> 00:22:51,870
+إذن في طريقتين للانتقال إما Transplacental من الأم
+
+312
+00:22:51,870 --> 00:22:55,690
+إلى الجنين أو عبر الـ respiratory droplets. The
+
+313
+00:22:55,690 --> 00:22:59,810
+disease is worldwide. In areas where the vaccine
+
+314
+00:22:59,810 --> 00:23:03,550
+is not used, epidemics occur every six to nine
+
+315
+00:23:03,550 --> 00:23:06,610
+years. المثال اللي ذكرناه قبل قليل، قلنا لكم إنه
+
+316
+00:23:06,610 --> 00:23:11,010
+كل ست إلى تسع سنوات بيحدث اللي هو التفشي أو
+
+317
+00:23:11,010 --> 00:23:16,780
+الوباء. في الـ 2005 الـ CDC واللي ما بيعوش الـ CDC لازم
+
+318
+00:23:16,780 --> 00:23:20,120
+يعرفه هو الـ Center for Disease Control في الولايات
+
+319
+00:23:20,120 --> 00:23:22,960
+المتحدة، إله أفراد كثيرة، لكن الفرع الرئيسي فيه
+
+320
+00:23:22,960 --> 00:23:27,640
+Atlanta في الولايات المتحدة، هذا المركز يُعتبر
+
+321
+00:23:27,640 --> 00:23:31,280
+المركز الأول في العالم في مكافحة الأمراض الماضية
+
+322
+00:23:31,830 --> 00:23:35,990
+وين في مرض غريب في العالم بيبعته أفراد من الـ CDC
+
+323
+00:23:35,990 --> 00:23:38,810
+عندهم مختبرات متطورة عندهم Epidemiologist عندهم
+
+324
+00:23:38,810 --> 00:23:44,210
+حواسيب عندهم برامج عندهم fund محترم جدًا لعملية
+
+325
+00:23:44,210 --> 00:23:47,050
+التعرف على الأمراض المواضية يعني هم الـ
+
+326
+00:23:47,050 --> 00:23:51,390
+microbusters هم اللي اللي بيلاحقوا الميكروبات في
+
+327
+00:23:51,390 --> 00:23:55,650
+العالم وخاصة الميكروبات الجديدة أو اللي تظهر حديثًا
+
+328
+00:23:56,850 --> 00:23:59,910
+موقعهم جاني بالمعلومات للي بيحب يعني يزيد من أي
+
+329
+00:23:59,910 --> 00:24:03,950
+ميكروب من الميكروبات يعرف عنه أي معلومات بيدخل على
+
+330
+00:24:03,950 --> 00:24:05,930
+الـ CDC.gov
+
+331
+00:24:12,260 --> 00:24:16,080
+أنا شخصيًا بستفيد منه خاصة في طائع المحاضرات لما
+
+332
+00:24:16,080 --> 00:24:20,240
+بيكون بدي update بدي أرقام جديدة و بدي أعمل محاضرة
+
+333
+00:24:20,240 --> 00:24:24,040
+لناس يعني متخصصين في المجال المعين و بدي أعطيهم
+
+334
+00:24:24,040 --> 00:24:27,860
+أرقام حديثة باخد من الـ CDC و من حاسبها ProMed يعني
+
+335
+00:24:27,860 --> 00:24:31,160
+و الـ WHO ده هو التلات مصادر الرئيسية اللي باخد
+
+336
+00:24:31,160 --> 00:24:36,600
+منهم معلومات عن الأمراض المؤدمة Elimination قررت
+
+337
+00:24:36,600 --> 00:24:42,780
+هذه المؤسسة أن الولايات المتحدة خالية من الحصبة
+
+338
+00:24:42,780 --> 00:24:49,480
+في 2005 وعزوا هذا الخلو من الحصبة إلى الاستخدام
+
+339
+00:24:49,480 --> 00:24:53,820
+الواسع لـ Vaccination Program As a result,
+
+340
+00:24:54,560 --> 00:24:58,180
+cytomegalovirus خلصنا من الحصبة اللي بتعمل
+
+341
+00:24:58,180 --> 00:25:01,320
+congenital abnormality وبالتالي مين أنصار الأول
+
+342
+00:25:01,320 --> 00:25:04,840
+صار الـ cytomegalovirus هو السبب الأول فيه اللي هو
+
+343
+00:25:04,840 --> 00:25:09,320
+الـ congenital abnormality برضه بنجر فعندها نقطة
+
+344
+00:25:09,320 --> 00:25:14,260
+صغيرة ونوضح بعض الأمور تسمع بمصطلح changing
+
+345
+00:25:14,260 --> 00:25:19,480
+epidemiology أو تغير الوبائيات تغير الوبائيات أنا
+
+346
+00:25:19,480 --> 00:25:24,400
+بدأ أقولكوا نماذج وهذا من النماذج أو نموذج من
+
+347
+00:25:24,400 --> 00:25:29,900
+النماذج الـ streptococcus pneumoniae كانت one of
+
+348
+00:25:29,900 --> 00:25:33,240
+the leading one of the leading causes of
+
+349
+00:25:33,240 --> 00:25:38,500
+meningitis in young children واحد من أهم مسببات
+
+350
+00:25:38,500 --> 00:25:42,120
+التهاب السحايا في العالم فهذه الـ pneumonia اشتبعتها
+
+351
+00:25:42,120 --> 00:25:46,340
+worldwide تمام؟ راح العالم عمل vaccine لـ
+
+352
+00:25:46,340 --> 00:25:49,230
+streptococcus pneumoniae لما عملنا فاكسينة لـ
+
+353
+00:25:49,230 --> 00:25:53,170
+Streptococcus pneumoniae قلت نسب الإصابة بالـ Otitis
+
+354
+00:25:53,170 --> 00:25:57,050
+Media و بالـ Eye Infection وبالتالي قلت كمان نسب
+
+355
+00:25:57,050 --> 00:26:01,270
+الإصابة بالتهاب السحايا الآن صار مين الأول؟
+
+356
+00:26:01,270 --> 00:26:04,630
+إشريكية كولاي يبقى ت .. ت .. لما أنا عملت
+
+357
+00:26:04,630 --> 00:26:09,050
+intervention تغيرت الوبائية اللي صالح مين؟ بصالح؟
+
+358
+00:26:09,050 --> 00:26:10,730
+مع أنه كانت .. ما كانت بالأول اللي هي الـ
+
+359
+00:26:10,730 --> 00:26:13,790
+Streptococcus pneumoniae الآن صارت مثلًا إشريكية
+
+360
+00:26:13,790 --> 00:26:19,760
+كولاي يبقى ما بنقدرش احنا نبقى نثبتنا المعلومة
+
+361
+00:26:19,760 --> 00:26:24,660
+ونقول أن المسبب الأول هو X إذا صار فيه
+
+362
+00:26:24,660 --> 00:26:29,120
+intervention أو صار فيه تغير في الوبائية يعني مثلًا
+
+363
+00:26:29,120 --> 00:26:33,180
+أنا دايمًا بقول الجملة دي وأنتم اسمعوها مرارًا أن
+
+364
+00:26:33,180 --> 00:26:37,540
+الأمراض المعدية كانت هي السبب في قتل 53% من سكان
+
+365
+00:26:37,540 --> 00:26:40,440
+العالم أو مش كل العالم عفواً من نسبة الوفيات في
+
+366
+00:26:40,440 --> 00:26:44,350
+العالم ثلاثة و خمسين بالمية اليوم حصدها جذاش ثلاثة
+
+367
+00:26:44,350 --> 00:26:47,690
+بالمية هتتغير في الوبائية ولا مش هتتغير في الوبائية
+
+368
+00:26:47,690 --> 00:26:51,890
+مرض السكر كان يصيب فقط من أعمارها من فوق الستين
+
+369
+00:26:51,890 --> 00:26:54,110
+اللي كان بيصيب الشباب اللي عمره عمري وعشرين سنة
+
+370
+00:26:54,110 --> 00:26:56,650
+من النوع الثاني لأ لأ من .. هذا كان النوع الأول
+
+371
+00:26:56,650 --> 00:26:59,010
+ممكن اللي هو النوع الثاني عشرين وثلاثين وأربعين
+
+372
+00:26:59,010 --> 00:27:01,990
+إذن الوبائية اللي بيبقى ملها تتغير فأنا أرجو من
+
+373
+00:27:01,990 --> 00:27:06,590
+حضراتكم تفهم هذا المصطلح أن changing epidemiology
+
+374
+00:27:06,590 --> 00:27:11,630
+أو epidemics تمام هذا مرهون بسلوك البشر و بال
+
+375
+00:27:11,630 --> 00:27:14,510
+intervention في الـ pollution في الـ global warming
+
+376
+00:27:14,510 --> 00:27:19,310
+في شرائط كتيرة في اكتشاف drugs في تعلم حقائق جديدة
+
+377
+00:27:19,310 --> 00:27:23,790
+يعني أنا جدناكوا غسل اليدين أنقذ حياة الملايين من
+
+378
+00:27:23,790 --> 00:27:26,850
+الأمهات في المستشفيات في عمليات الولادة لما
+
+379
+00:27:26,850 --> 00:27:30,890
+تعلموا غسل اليدين فقط فدائما بدنا نفهم أن
+
+380
+00:27:30,890 --> 00:27:34,690
+الأرقام اللي بنذكرها مش بالضرورة تبقى هي نفس
+
+381
+00:27:34,690 --> 00:27:38,810
+الأرقام اللي تعلمناها أيام الدراسة قد تتغير ولازم 
+
+382
+00:27:38,810 --> 00:27:43,690
+يكون المفهوم لدينا أن هذا التغير مبرر بأنه صار فيه
+
+383
+00:27:43,690 --> 00:27:48,710
+intervention من قبل البشر أو تغير معين لما عملنا
+
+384
+00:27:48,710 --> 00:27:53,810
+الـ vaccine كانت النكاف رقم واحد في الـ congenital
+
+385
+00:27:53,810 --> 00:27:56,270
+abnormality عملنا الـ vaccine صار مين الـ number
+
+386
+00:27:56,270 --> 00:28:00,310
+one؟ Cytomegalovirus هذا المقصود في changing
+
+387
+00:28:00,310 --> 00:28:04,570
+epidemiology أو تلقاء اللي بيأَن Rubella is a milder
+
+388
+00:28:04,570 --> 00:28:11,550
+يعني أخف shorter فترة المرض أقصر disease than
+
+389
+00:28:11,550 --> 00:28:16,150
+measles دائما بنقارن Rubella بمين؟ بالميسلز after
+
+390
+00:28:16,150 --> 00:28:18,710
+an incubation period of fourteen to twenty-one
+
+391
+00:28:18,710 --> 00:28:23,110
+days a brief prodromal period of fever and malaise
+
+392
+00:28:23,110 --> 00:28:27,230
+is followed by maculopapular rashes اللي هو نفس
+
+393
+00:28:27,230 --> 00:28:32,510
+الرش تبع مين؟ الميسلز بيبدأ برضه بالـ face وبينتقل
+
+394
+00:28:32,510 --> 00:28:37,810
+إلى الجسم ومن ثم إلى اليدين إيش اختلاف طبعا عن الـ
+
+395
+00:28:37,810 --> 00:28:42,970
+measles اختلاف إيش إيه؟ فيه حد ما ذكرناهاش هنا و
+
+396
+00:28:42,970 --> 00:28:46,690
+ذكرناها في الـ measles مين بتذكرها؟
+
+397
+00:28:50,330 --> 00:28:55,050
+كوبليك سبوت هي الإحمرار اللي موجود في الـ buccal
+
+398
+00:28:55,050 --> 00:28:58,570
+cavity، النقاط الحمرة، الـ spots تمام؟ الحمرة اللي
+
+399
+00:28:58,570 --> 00:29:03,250
+فيها white dots، كمان فيها نقاط بيضاء، قولنا عنها
+
+400
+00:29:03,250 --> 00:29:07,390
+هادي characteristic للميسلز، غير موجود في مين؟ في
+
+401
+00:29:07,390 --> 00:29:11,950
+الـ German measles أو في الربينة Posterior
+
+402
+00:29:11,950 --> 00:29:16,330
+Auricular Lymphadenopathy is characteristics هنا
+
+403
+00:29:16,330 --> 00:29:21,570
+هنا إذا بكتبها في أن روبيللا دائما وأبدا في
+
+404
+00:29:21,570 --> 00:29:25,810
+انتفاخ ورا الأذن هذا معناه لـ posterior auricular
+
+405
+00:29:25,810 --> 00:29:28,810
+lymphadenopathy الانتفاخ هنا نتيجة عن الـ swelling
+
+406
+00:29:28,810 --> 00:29:33,150
+في الـ lymph node الموجودة في المنطقة ورا الأذن هذه
+
+407
+00:29:33,150 --> 00:29:37,090
+الـ characteristics وجودها تقريبا وجودها يعني
+
+408
+00:29:37,090 --> 00:29:43,180
+روبيللا مع شوية trash معناها روبيللا وصلت؟ The rash
+
+409
+00:29:43,180 --> 00:29:46,160
+typically lasts for three days، short period، يعني
+
+410
+00:29:46,160 --> 00:29:49,680
+فترة قصيرة، when rubella occurs in adults، لما
+
+411
+00:29:49,680 --> 00:29:53,700
+تصير في الناس البالغين especially women،
+
+412
+00:29:53,700 --> 00:29:57,800
+polyarthritis، إيش يعني polyarthritis؟ كل المفاصل
+
+413
+00:29:57,800 --> 00:30:01,420
+الآن في المفاصل بشكل عام، نتيجة عن إيش الـ
+
+414
+00:30:01,420 --> 00:30:05,480
+polyarthritis؟ Antigen-antibody complexes،
+
+415
+00:30:05,480 --> 00:30:07,560
+deposition في هذه المفاصل
+
+416
+00:30:10,330 --> 00:30:15,830
+Congenital Rubella Syndrome بيسموها Teratogen أي
+
+417
+00:30:15,830 --> 00:30:21,350
+مركب بيأثر على الأجنة بيسميه Teratogen. Pregnant
+
+418
+00:30:21,350 --> 00:30:27,630
+woman is infected during the first trimester. الأول
+
+419
+00:30:27,630 --> 00:30:34,050
+ثلاثة شهور. Especially the first month significant
+
+420
+00:30:34,050 --> 00:30:38,650
+congenital malformation can occur. إذا كان في الشهر
+
+421
+00:30:38,650 --> 00:30:43,930
+الأول أسوأ من الشهر الثاني أسوأ أسوأ من الشهر
+
+422
+00:30:43,930 --> 00:30:47,290
+الثاني يعني بمعنى آخر كل ما تقدمنا بيخف الضرر لأ
+
+423
+00:30:47,290 --> 00:30:53,110
+بيخف الضرر البداية هي الأسوأ البداية هي الأسوأ the
+
+424
+00:30:53,110 --> 00:30:55,330
+increased rate of abnormalities during the early
+
+425
+00:30:55,330 --> 00:30:58,310
+weeks of pregnancy is attributed to the very
+
+426
+00:30:58,310 --> 00:31:01,350
+sensitive organ development that occurred at that
+
+427
+00:31:01,350 --> 00:31:06,950
+time طبعا أنتو عارفين أنه في بداية التكون التخصيب
+
+428
+00:31:06,950 --> 00:31:11,290
+الجنين الـ zygote الانقسام مش بيكون .. بيكون أسرع من
+
+429
+00:31:11,290 --> 00:31:15,470
+البرق، يعني انقسام سريع وهذه مرحلة حساسة wherein
+
+430
+00:31:15,470 --> 00:31:19,590
+organ development starts فلما الفيروس يكون في هذه
+
+431
+00:31:19,590 --> 00:31:23,830
+المرحلة .. تذكروا المقولة طبعتنا الشهيرة أنه كل ما
+
+432
+00:31:23,830 --> 00:31:28,190
+كان العمل كثير، كل ما كان الخطأ كثير فالفيروس
+
+433
+00:31:28,190 --> 00:31:33,910
+بيكون مشط جدا مع هذه أيضا الخلايا وبالتالي بالفعل
+
+434
+00:31:33,910 --> 00:31:40,320
+بيكون الضرر عالي جدا إذا هذه المرحلة مرحلة الـ organ
+
+435
+00:31:40,320 --> 00:31:44,280
+development، the malformations are widespread يعني
+
+436
+00:31:44,280 --> 00:31:49,240
+مش بتكون في عضو معين، بتكون في أعضاء متنوعة and
+
+437
+00:31:49,240 --> 00:31:52,460
+can involve primarily the heart, the eyes and the
+
+438
+00:31:52,460 --> 00:31:58,320
+brain، إذا في أعضاء مختلفة لكن أهمها بالنسبة لنا
+
+439
+00:31:58,320 --> 00:32:03,020
+اللي هو القلب والعينين والدماغ In addition, some
+
+440
+00:32:03,020 --> 00:32:12,520
+children infected in utero
+
+441
+00:32:12,520 --> 00:32:18,260
+can continue to excrete rubella virus for months
+
+442
+00:32:18,260 --> 00:32:19,640
+following birth
+
+443
+00:32:22,040 --> 00:32:25,760
+إن ولد وكانت أمه مصابة ونقلته الفيروس حتى وإن لم
+
+444
+00:32:25,760 --> 00:32:30,700
+يبدو عليه أي أعراض هو نفسه بيكون مصدر للفيروس لعدة
+
+445
+00:32:30,700 --> 00:32:35,390
+أشهر يعني بيعمل secretion لهذا الفيروس بعض الـ
+
+446
+00:32:35,390 --> 00:32:40,730
+congenital shedders يعني المفرزين، يشدوا الفيروس،
+
+447
+00:32:40,730 --> 00:32:44,290
+يعني هم ينتجوا الفيروس، هم يفرزوا الفيروس، هم
+
+448
+00:32:44,290 --> 00:32:47,490
+أعراضيين وليسوا مشوهين، كل هذا ما
+
+449
+00:32:47,490 --> 00:32:49,810
+حكيناه، قولنا لكوا أنه سواء كان عنده مشوهين
+
+450
+00:32:49,810 --> 00:32:53,570
+أو ما عندهوش، مشوهين ممكن ينتج الفيروس
+
+451
+00:32:53,570 --> 00:32:58,860
+ويعمله spread and hence can be diagnosed only if
+
+452
+00:32:58,860 --> 00:33:03,560
+the virus is isolated يعني مايقدرش نعرف إنه هذا
+
+453
+00:33:03,560 --> 00:33:08,540
+مصاب إلا إذا احنا جينا بعازل إيه؟ اللي هو الفيروس
+
+454
+00:33:08,540 --> 00:33:14,220
+وطبعا واحد apparently healthy هل هناك داعي أن
+
+455
+00:33:14,220 --> 00:33:19,140
+نفحصه للروبيلا؟ إلا إذا الأم أظهرت symptoms لمن؟
+
+456
+00:33:19,140 --> 00:33:23,060
+للروبيلا، فبالتالي المولود حتى وإن كان healthy، he
+
+457
+00:33:23,060 --> 00:33:26,740
+should be investigated for جنين اللي هو الروبيلا
+
+458
+00:33:45,680 --> 00:33:53,070
+الأطفال اللي بنولدوا وعندهم إصابة بالروبيلا بيكون
+
+459
+00:33:53,070 --> 00:33:57,550
+عندهم IgM و IgG that can last for longer periods
+
+460
+00:33:57,550 --> 00:34:00,970
+احنا بنلاحظ أنه على 6 شهور ل 15 شهر بتختفي الـ
+
+461
+00:34:00,970 --> 00:34:05,410
+maternal antibody لها ده الـ virus لكن المصابين لأ
+
+462
+00:34:05,410 --> 00:34:10,910
+بيضال عندهم لفترات طويلة الـ lab diagnosis روبيلا
+
+463
+00:34:10,910 --> 00:34:14,530
+virus can be grown in cell culture with little
+
+464
+00:34:14,530 --> 00:34:20,440
+cytopathic effect يعني مالهاش CPE واضح عادةً يتم
+
+465
+00:34:20,440 --> 00:34:24,360
+اكتشافها باستخدام قدرتها على الانتفاق مع الـ
+
+466
+00:34:24,360 --> 00:34:30,260
+Echovirus-CPE. إيش هينتفير مع الـ Echovirus-CPE؟ لأن
+
+467
+00:34:30,260 --> 00:34:33,820
+الـ Echovirus يا بنات، هذا إيه اللي هو الـ CPE؟
+
+468
+00:34:33,820 --> 00:34:37,100
+زراعنا عصر الكرشة بيعمل الـ CPE، دائما بيعمل نفس
+
+469
+00:34:37,100 --> 00:34:42,740
+الـ CPE لو زرعت معاه روبيلا بيمنع الـ echo virus من
+
+470
+00:34:42,740 --> 00:34:48,380
+أنه يعمل CPE فبنتعرف على الربيلا من خلال منعه للـ
+
+471
+00:34:48,380 --> 00:34:53,960
+echo virus CPE فسموه interference test إذا كانت
+
+472
+00:34:53,960 --> 00:34:57,960
+روبيلا بياس موجودة في مصطلح الشخص، وكانت مبتدئة في
+
+473
+00:34:57,960 --> 00:35:01,700
+ثلاجة ثقافات، فلا CPE سيظهر عندما تكون الثقافة
+
+474
+00:35:01,700 --> 00:35:04,580
+مصابة بالإنفاق مع إيكو بياس
+
+475
+00:35:11,690 --> 00:35:15,830
+كمان طريقة أخرى في الـ diagnosis هو الأنشودة
+
+476
+00:35:15,830 --> 00:35:20,710
+المعروفة صارت أنه الارتفاع بأربعة أضعاف أو أكثر في
+
+477
+00:35:20,710 --> 00:35:24,190
+مستوى الـ antibody ما بين عينة الـ acute ما بين عينة
+
+478
+00:35:24,190 --> 00:35:27,370
+اللي هو الـ convalescent serum هو المرة المليون
+
+479
+00:35:27,370 --> 00:35:32,170
+جونالكو البعض بيظن أن هذا النوع من الفحوصات ليس له
+
+480
+00:35:32,170 --> 00:35:37,790
+أي قيمة للمريض لإله قيمة إله قيمة أنه يعني عملنا
+
+481
+00:35:37,790 --> 00:35:42,330
+confirm للحالة أنه سجلناها رقم اتنين أنه لو ماصارش
+
+482
+00:35:42,330 --> 00:35:44,750
+فيه increase يا جماعة مانا الحاجة أن المريض ممكن
+
+483
+00:35:44,750 --> 00:35:49,070
+يكون مريض بمرض آخر وبالتالي لازم نبحث عن هذا
+
+484
+00:35:49,070 --> 00:35:52,710
+المرض، إذا to confirm a case is an essential
+
+485
+00:35:52,710 --> 00:35:57,130
+diagnostic requirement for epidemiological reason
+
+486
+00:35:57,130 --> 00:36:01,920
+وممكن for the sake of the patient بعض الأحيان By
+
+487
+00:36:01,920 --> 00:36:06,540
+observing the presence of IgM antibody in a single
+
+488
+00:36:06,540 --> 00:36:10,560
+acute phase serum sample يعني الـ IgG هو اللي بده
+
+489
+00:36:10,560 --> 00:36:14,800
+four fold increase لكن لو دورنا ع الـ IgM وطبعا
+
+490
+00:36:14,800 --> 00:36:19,200
+لأن الربلة من الفحوصات اللي لها علاقة بالإجهاض
+
+491
+00:36:19,570 --> 00:36:24,190
+وبـ Pregnancy ففي غزة هنا لابد أن تكون متوفرة
+
+492
+00:36:24,190 --> 00:36:28,310
+في كل مكان لأن احنا شعب بيحب اللي هو يعني مايصيرش
+
+493
+00:36:28,310 --> 00:36:31,730
+عنده إجهاض وأنه يكون عنده يعني أو يعرف سبب
+
+494
+00:36:31,730 --> 00:36:34,210
+عشان المرأة القادمة مايصيرش في عندنا إجهاض
+
+495
+00:36:34,210 --> 00:36:38,190
+الربلة واحدة من مسببات الإجهاض والـ congenital
+
+496
+00:36:38,190 --> 00:36:41,910
+abnormality وربما يكون الـ failure في الـ IVF اللي
+
+497
+00:36:41,910 --> 00:36:45,330
+هي زراعة الجنين in vitro
+
+498
+00:36:48,360 --> 00:36:51,640
+In a pregnant woman exposed to rubella virus, the
+
+499
+00:36:51,640 --> 00:36:54,980
+presence of IgM antibody indicates recent
+
+500
+00:36:54,980 --> 00:36:55,420
+infection
+
+501
+00:37:03,110 --> 00:37:07,690
+Whereas one to eight or greater titers of IgG
+
+502
+00:37:07,690 --> 00:37:11,150
+antibody indicates immunity and consequent
+
+503
+00:37:11,150 --> 00:37:16,030
+protection of the fetus يعني لو جئنا عند السيدة 
+
+504
+00:37:16,030 --> 00:37:21,230
+تايتر من IgG واحد إلى ثمانية تمام واحد على ثمانية
+
+505
+00:37:21,230 --> 00:37:24,910
+يعني إحنا بنقول لكم واحد نص ربع ثمن واحد على ستة عشر
+
+506
+00:37:24,910 --> 00:37:27,810
+واحد على اثنين وثلاثين إذا جئنا واحد على ثمانية أو
+
+507
+00:37:27,810 --> 00:37:30,130
+أقل اللي هو واحد على ستة عشر أو واحد على
+
+508
+00:37:33,550 --> 00:37:39,910
+السيدة لديها مناعة كافية وبالتالي هي محمية من أن
+
+509
+00:37:39,910 --> 00:37:42,070
+تصاب بالربلا
+
+510
+00:37:47,190 --> 00:37:50,130
+أمنيو سنتيسيس Amniocentesis اللي هو الحصول على
+
+511
+00:37:50,130 --> 00:37:55,510
+السائل الأمنيوسي سائل الأمنيوسي can reveal whether
+
+512
+00:37:55,510 --> 00:37:58,490
+there is a rubella virus in the amniotic fluid
+
+513
+00:37:58,490 --> 00:38:03,110
+which indicates definite fetal infection كلمة fetal
+
+514
+00:38:03,110 --> 00:38:07,370
+infection يعني الإصابة في الجنين سوف تؤكد من خلال
+
+515
+00:38:07,370 --> 00:38:14,860
+هذا الفحص طبعًا هذا أيضًا يعني برضه فحص جيد لأن إحنا
+
+516
+00:38:14,860 --> 00:38:18,960
+بنعرف إن الطفل مصاب أو غير مصاب قبل حتى قبل خروجه
+
+517
+00:38:18,960 --> 00:38:24,920
+إلى الحياة treatment there is no antiviral therapy
+
+518
+00:38:24,920 --> 00:38:28,880
+الـ prevention involves immunization with live
+
+519
+00:38:28,880 --> 00:38:32,120
+attenuated vaccine كلكم عارفين إن هو جزء من مين؟
+
+520
+00:38:32,120 --> 00:38:37,740
+من طعوم اللي هو الـ MMR produces at least 10 years
+
+521
+00:38:37,740 --> 00:38:42,310
+of immunity بعطينا عشر سنوات تقريبًا من المناعة It
+
+522
+00:38:42,310 --> 00:38:46,650
+is given subcutaneously to children at 15 months
+
+523
+00:38:46,650 --> 00:38:49,790
+of age وإحنا ذكرنا ليش 15 month لأنه بيقولنا لكم
+
+524
+00:38:49,790 --> 00:38:52,490
+إن الـ .. الـ .. الـ maternal antibody بتكون موجودة و
+
+525
+00:38:52,490 --> 00:38:56,490
+protective لِلدّ الطفل It is also given to
+
+526
+00:38:56,490 --> 00:39:00,470
+unimmunized young adult women if they are not
+
+527
+00:39:00,470 --> 00:39:05,690
+pregnant يعني مش خلال الحمل وإنما قبل الحمل and
+
+528
+00:39:05,690 --> 00:39:09,310
+will use contraceptive for the next three months
+
+529
+00:39:09,310 --> 00:39:13,270
+يعني مضمون إنها ما تحملش كمان ثلاثة شهور، تمام؟ يعني
+
+530
+00:39:13,270 --> 00:39:17,930
+ما بدناش نعطيها الـ vaccine وتحمل بكرة أو تحمل
+
+531
+00:39:17,930 --> 00:39:22,170
+الأسبوع اللي جاي، ليش؟ لأنه لسه .. لأن هذا live
+
+532
+00:39:22,170 --> 00:39:26,670
+attenuated الـ virus، صح؟ ممكن ينتقل لمين؟ للجنين
+
+533
+00:39:26,670 --> 00:39:31,470
+اللي يعمل real infection لا يوجد أي إثبات إن 
+
+534
+00:39:31,470 --> 00:39:38,870
+الفيروس يسبب فيه malformation، لكن للخشية والنظرية
+
+535
+00:39:38,870 --> 00:39:42,430
+اللي بنحكي لكم عنها لما اتكلمنا عن الـ live vaccine و
+
+536
+00:39:42,430 --> 00:39:45,550
+الـ killed vaccine إبنها، أحد المخاوف اللي ذكرناها
+
+537
+00:39:45,550 --> 00:39:49,450
+إن الـ live الـ attenuated is to revert to the
+
+538
+00:39:49,450 --> 00:39:53,620
+active form هذه مخاوف نظرية لم نرها إلا أظن مرة
+
+539
+00:39:53,620 --> 00:39:58,280
+واحدة في الـ polio vaccine وقلنا لكم يعني هذا ممكن
+
+540
+00:39:58,280 --> 00:40:02,320
+تخيل إحنا بنحتفل قاعدين إنّه إنتهينا من مين؟ من الـ
+
+541
+00:40:02,320 --> 00:40:07,060
+polio وبعدين نرجع مرة ثانية لـ polio disease
+
+542
+00:40:09,730 --> 00:40:12,170
+Because it is a live vaccine, it should not be
+
+543
+00:40:12,170 --> 00:40:14,770
+given to immunocompromised patients or to pregnant
+
+544
+00:40:14,770 --> 00:40:18,050
+women. The vaccine has caused a significant
+
+545
+00:40:18,050 --> 00:40:21,290
+reduction in the incidence of both rubella and
+
+546
+00:40:21,290 --> 00:40:23,490
+congenital rubella syndrome
+
+547
+00:40:29,490 --> 00:40:35,850
+It induces respiratory IgA وإحنا قلنا لكم إن الـ
+
+548
+00:40:35,850 --> 00:40:40,950
+IgA كثير مهم في هذا النوع من الفيروسات لأن معظم الـ
+
+549
+00:40:40,950 --> 00:40:44,690
+transmission بيتم عبر اللي هو الـ respiratory tract
+
+550
+00:40:44,690 --> 00:40:48,890
+Immune serum globulin can be given to pregnant
+
+551
+00:40:48,890 --> 00:41:00,540
+women in the first trimester who have been exposed to a known case of rubella سيدة حامل وراحت زارت
+
+553
+00:41:00,540 --> 00:41:03,660
+جدّتها 
+
+554
+00:41:03,660 --> 00:41:09,340
+صاحبتها واكتشفت إن صاحبتها أصلًا عندها حُصبة ألمانية
+
+555
+00:41:09,340 --> 00:41:14,040
+أو تعرضت لابن صاحبتها أو بنت صاحبتها المصاب من
+
+556
+00:41:14,040 --> 00:41:18,360
+بالربلا يعني إيش معناه؟ إيش .. إيش .. إيش هي وضعها؟
+
+557
+00:41:18,360 --> 00:41:25,820
+exposed صارت هي معرضة وحامل هل نُعطيها فاكسين؟
+
+558
+00:41:25,820 --> 00:41:28,460
+هل نُعطيها فاكسين، إيش مانعطيها في هذه الحالة؟
+
+559
+00:41:28,460 --> 00:41:33,060
+immunoglobulin تمام؟ to protect her and to protect
+
+560
+00:41:33,060 --> 00:41:35,320
+her baby في هذه الحالة
+
+561
+00:41:39,330 --> 00:41:42,330
+Immune serum globulin can be given to pregnant
+
+562
+00:41:42,330 --> 00:41:45,250
+women in the first trimester who have been exposed
+
+563
+00:41:45,250 --> 00:41:49,250
+to a known case of rubella and for whom
+
+564
+00:41:49,250 --> 00:41:53,750
+termination of pregnancy is not an option. طبعًا
+
+565
+00:41:53,750 --> 00:41:59,230
+أنتوا عارفين الإجهاض عند الأجانب في بعض الدول
+
+566
+00:41:59,230 --> 00:42:02,090
+مشروع يعني هو مرتبط أنه يحصل فيه إجهاض حتى لو
+
+567
+00:42:02,090 --> 00:42:06,390
+بناءً على توقّع تمام فبيقولك إنه في حالة إنه
+
+568
+00:42:12,200 --> 00:42:20,660
+المشكلة الرئيسية في الـ immunoglobulin هي أن هناك
+
+569
+00:42:20,660 --> 00:42:26,180
+حالات فيها التي لا تنجح لإيقاف التأثير الفيروسي على
+
+570
+00:42:26,180 --> 00:42:30,820
+الرغم من النجاحات اللي حققها إلا إن هناك حالات فشل
+
+571
+00:42:30,820 --> 00:42:38,160
+الـ immunoglobulin أن يحدث مناعة للإصابة بالـ fetal أو
+
+572
+00:42:38,160 --> 00:42:41,740
+الـ congenital rubella، إذا مش hundred percent
+
+573
+00:42:45,600 --> 00:43:02,140
+الجملة الأخيرة أو الفقرة الأخيرة تخيلوا
+
+574
+00:43:02,140 --> 00:43:06,280
+للممرض ولطبيب عنده Rubella وخاصة في النساء
+
+575
+00:43:06,280 --> 00:43:11,080
+والولادة اللي بيرجعوا عندهم النساء والحيوانات،
+
+576
+00:43:11,080 --> 00:43:15,680
+مشكلة كبيرة لو ده لأ، لذلك إيش سياسة المستشفى؟
+
+577
+00:43:15,680 --> 00:43:20,780
+سياسة المستشفى إنه لازم يجيب شهادة إنه مطعم أو فحص
+
+578
+00:43:20,780 --> 00:43:24,660
+إنه بيحتوي على اللي هو immunoglobulin بشكل عالي،
+
+579
+00:43:24,660 --> 00:43:30,460
+إنه protected عشان برضه نمنع اللي هو أو نكسر الـ
+
+580
+00:43:30,460 --> 00:43:34,820
+cycle اللي ممكن تؤدي إلى انتشار الـ virus من الـ
+
+581
+00:43:34,820 --> 00:43:38,340
+personnel إلى الـ .. الـ .. الـ النساء إلى حوالي
+
+582
+00:43:38,340 --> 00:43:41,580
+المرأة الجاية إن شاء الله بنكمل الفقرات اللي باقية
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1075c35dab57acffa6e9050d62a5c340a8cc3c86
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho_postprocess.srt
@@ -0,0 +1,2328 @@
+1
+00:00:20,970 --> 00:00:24,870
+بسم الله الرحمن الرحيم نكمل RNA-Enveloped Viruses
+
+2
+00:00:24,870 --> 00:00:28,150
+اليوم أو المحاضرة السابقة انتهينا من ال
+
+3
+00:00:28,150 --> 00:00:31,590
+Paramyoxivirus دي اللي شملت مجموعة من الفيروسات زي
+
+4
+00:00:31,590 --> 00:00:34,970
+ال missiles و ال mumps و ال para influenza و ال
+
+5
+00:00:34,970 --> 00:00:39,670
+respiratory syncytial virus و بدأنا بمقدمة بسيطة
+
+6
+00:00:39,670 --> 00:00:42,810
+عن الكورونا فيروس و كنا الكورونا فيروس لم تكن
+
+7
+00:00:42,810 --> 00:00:49,840
+مشهورةقبل 2002 يعني انشهرت بعد ظهور مرض ال SARS
+
+8
+00:00:49,840 --> 00:00:54,140
+وازدادت شهرتها بعد قبل سنتين عند ظهور جونا ال
+
+9
+00:00:54,140 --> 00:00:58,420
+middle east respiratory syndrome هو ال ميرس كورونا
+
+10
+00:00:58,420 --> 00:01:05,120
+في الخليج العربياللي هي واحدة من أهم مسببات ال
+
+11
+00:01:05,120 --> 00:01:09,480
+common cold يعني تالي في الأهمية ال rhinovirus
+
+12
+00:01:09,480 --> 00:01:12,760
+وزمان ما ذكرنالكم في 2002 تم اكتشاف اللي هو
+
+13
+00:01:12,760 --> 00:01:18,260
+atypical pneumonia بفيروس لما شرحنا الفيروس
+
+14
+00:01:18,260 --> 00:01:24,770
+ودرسناه لجينا هو coronavirusشكلًا و تركيبًا لكن ال
+
+15
+00:01:24,770 --> 00:01:27,870
+sequence analysis زي ما ذكرنا في المحاضرة السابقة
+
+16
+00:01:27,870 --> 00:01:32,630
+ال sequence analysis لل DNA لل coronavirus لجنة
+
+17
+00:01:32,630 --> 00:01:36,490
+مختلفة عن ال other .. عفوا لل SARS لجنة مختلفة عن
+
+18
+00:01:36,490 --> 00:01:39,810
+ال other coronavirus لكن ال isolates of
+
+19
+00:01:39,810 --> 00:01:44,990
+coronaviruses أعطتنا similar sequence أو DNA
+
+20
+00:01:44,990 --> 00:01:49,730
+sequence هذا مؤشر على ايه؟على انه التركيب تبع ال
+
+21
+00:01:49,730 --> 00:01:53,590
+.. ال .. ال .. ال SARS viruses او strains شبيه
+
+22
+00:01:53,590 --> 00:01:58,690
+وبالتالي التوقع كان ان ال antigen تبعهم يكون واحد
+
+23
+00:01:58,690 --> 00:02:02,750
+ويكون stable كمان يكون stable زي ما ذكرنا في أحد
+
+24
+00:02:02,750 --> 00:02:10,230
+اللوحات نعمانا عندى لان corona viruses واحد منهم
+
+25
+00:02:10,230 --> 00:02:15,370
+اتشفناه جديد اسمه SARS شكلا و مضمونا بيشبه بيشبه
+
+26
+00:02:15,370 --> 00:02:18,210
+ال other corona viruses تمام؟ لكن لما عملنا
+
+27
+00:02:18,210 --> 00:02:21,370
+sequence analysis لل SARS virus اللي جدا بيختلف
+
+28
+00:02:21,370 --> 00:02:25,550
+بشكل كبير عن اللي هو مين عن ال other corona virus
+
+29
+00:02:25,550 --> 00:02:30,420
+لان ال SARS برضه انا عزل منه اكتر من عزلةلما جينا
+
+30
+00:02:30,420 --> 00:02:33,540
+عملنا sequence analysis لل سارس المختلفة لجيناهم
+
+31
+00:02:33,540 --> 00:02:36,980
+بيشبهوا بعض إلى حد كبير فتوقعنا ان يكون ال antigen
+
+32
+00:02:36,980 --> 00:02:40,980
+تبعهم ان يكون one ويكون stable هذا ال antigen هذا
+
+33
+00:02:40,980 --> 00:02:45,780
+الفكرة كانت فيه اللي هو الحديث تبعنا من المميزات
+
+34
+00:02:45,780 --> 00:02:48,340
+لل Corona فيها تقولنا اللي هو ال club shape spikes
+
+35
+00:02:48,340 --> 00:02:50,740
+اللي الكبيرة هذه اللي شايفينها تبعها و الشكل
+
+36
+00:02:50,740 --> 00:02:56,850
+الجميل اللي اعطاها شكل اللي هو ال Coronaوزي
+
+37
+00:02:56,850 --> 00:02:59,490
+الاخرين اللي متحدثناه ان هو بينتقل عنبر اللي هو ال
+
+38
+00:02:59,490 --> 00:03:03,170
+respiratory to aerosols و ال infection can occur
+
+39
+00:03:03,170 --> 00:03:06,170
+worldwide انا دلوقتي اخدوا بالكوا في ال .. في ال
+
+40
+00:03:06,170 --> 00:03:09,470
+chapter هذا فيه هيصير فيه mixed up شوية مرة اتكلم
+
+41
+00:03:09,470 --> 00:03:13,690
+عن ال stars بخص .. بخصوصية و مرة اتكلم عن مين عن
+
+42
+00:03:13,690 --> 00:03:17,050
+ال coronavirus عندما انا اتكلم عن ال stars هنقول
+
+43
+00:03:17,050 --> 00:03:19,970
+انهم اتكلم عن ال stars بس في الواقع الحديث معاهم
+
+44
+00:03:19,970 --> 00:03:23,250
+يقولوا حول مين؟ حول اللي هو ال coronavirus خاصة في
+
+45
+00:03:23,250 --> 00:03:27,750
+ال characteristics العامة اللي منذ القرننصف أو
+
+46
+00:03:27,750 --> 00:03:32,270
+أكتر من نصف الأطفال أصيبوا بال coronavirus و اللي
+
+47
+00:03:32,270 --> 00:03:35,350
+أقصد فيها ال SARS تمام؟ ال coronavirus اللي بتسبب
+
+48
+00:03:35,350 --> 00:03:38,950
+الرشح اللي حكينا عنه ال outbreaks كنا بتحدث من
+
+49
+00:03:38,950 --> 00:03:44,260
+سنتين إلى تلت سنوات مش كل سنة زي مين كل سنةالـ
+
+50
+00:03:44,260 --> 00:03:47,080
+Respiratory syncytial و الـ Respiratory syncytial
+
+51
+00:03:47,080 --> 00:03:54,420
+virus و ذكرنا التفسير الهلمى لماذا هناك فترات
+
+52
+00:03:54,420 --> 00:04:00,120
+زمانية بين حدوث الأوبيا لنفس الميكروب مثلا هنشوف
+
+53
+00:04:00,120 --> 00:04:05,840
+كمان شوية ميكروب كل ستة لتسع سنوات بيعمل cycle من
+
+54
+00:04:05,840 --> 00:04:10,190
+out breaksالـ number of children أو ال number of
+
+55
+00:04:10,190 --> 00:04:13,530
+susceptible population لازم يكون enough for this
+
+56
+00:04:13,530 --> 00:04:18,500
+virus to produce outbreakفي ال .. في ال
+
+57
+00:04:18,500 --> 00:04:22,060
+respiratory syncytial virus كانت سنوية صح؟ هذا
+
+58
+00:04:22,060 --> 00:04:25,520
+معناه يحكي إن ال immunity completely incomplete
+
+59
+00:04:25,520 --> 00:04:30,620
+يعني هي أصلا مش تانمة وبالتالي كل سنة معرض إن
+
+60
+00:04:30,620 --> 00:04:35,200
+الناس ينصب هذا ال virus لكن لو ينصبوا بالربلة،
+
+61
+00:04:35,200 --> 00:04:39,910
+حيصير فيه انديواباة، القفار ممكن تموتواطفال كثيرة
+
+62
+00:04:39,910 --> 00:04:44,610
+هينجو ويكونوا مناعة السنة الجاية لو الفيروس اجا
+
+63
+00:04:44,610 --> 00:04:50,290
+نسبة الاعظم من الأطفال عندهم مناعة فبفكرة ال herd
+
+64
+00:04:50,290 --> 00:04:54,310
+immunity او ال community immunity لن يستطيع الربلة
+
+65
+00:04:54,310 --> 00:04:58,830
+ان يعمل وباء الا بعد مرور فترة من الزمن وظهور
+
+66
+00:04:58,830 --> 00:05:03,350
+اطفال جدد بكمية كافية لاحدات اللي هو الوباء ارجو
+
+67
+00:05:03,350 --> 00:05:07,030
+ان هذه النقطة تكون خلاص يعني اختمرت فيها أقولكم ان
+
+68
+00:05:07,030 --> 00:05:13,220
+شاء اللهال سارس originated in China في الصين في
+
+69
+00:05:13,220 --> 00:05:21,560
+نوفمبر 2002 وانتقل بشكل سريع إلى بلدان أخرىعندما
+
+70
+00:05:21,560 --> 00:05:26,920
+كنت بهذه الشرايح كان عادل حالات المصابة حوالي 9000
+
+71
+00:05:26,920 --> 00:05:33,280
+ومات منهم حوالي 800 بنسبة 13% mortality rate اعتقد
+
+72
+00:05:33,280 --> 00:05:37,640
+ان 13% mortality rate هذا رقم خطير ولا لا؟ يعني من
+
+73
+00:05:37,640 --> 00:05:41,540
+كل 100 شخص 13 واحد بدوا يموت هذا رقم بالفعل بيكون
+
+74
+00:05:41,540 --> 00:05:45,900
+صعب بالغايةالـ transmission and epidemiology
+
+75
+00:05:45,900 --> 00:05:50,720
+الانتقال أول ما صار انتقال في المستشفيات يعني
+
+76
+00:05:50,720 --> 00:05:55,220
+المريض اللي إجا مصاب نقل لمين؟ لل health care
+
+77
+00:05:55,220 --> 00:06:01,360
+workers واعتقدوا أنه حتى أن الناس المصابين في منهم
+
+78
+00:06:01,360 --> 00:06:05,110
+مجموعة بسموهم super spreaderإيش يعني super
+
+79
+00:06:05,110 --> 00:06:10,790
+spreader؟ يعني وجود الفيروس في هذا الإنسان بيجعل
+
+80
+00:06:10,790 --> 00:06:14,630
+هذا الإنسان قادر على نقله إلى عدد كبير جدا من مين؟
+
+81
+00:06:14,630 --> 00:06:18,730
+من الناس الآخرين، فبيسموهم super spreader لكن هذا
+
+82
+00:06:18,730 --> 00:06:23,930
+المصطلح yet to be confirmedلحد الآن لم يثبت علميا
+
+83
+00:06:23,930 --> 00:06:27,490
+انه فيه انحاء اسمها super spreader لكن كان فيه
+
+84
+00:06:27,490 --> 00:06:31,930
+prediction او تنبؤات انه ممكن يكون super spreader
+
+85
+00:06:31,930 --> 00:06:35,570
+التنبؤات هي بناء على ايه؟ بناء على ما رأوهم
+
+86
+00:06:35,570 --> 00:06:39,710
+الملاحظات وانتشار سريع في بعض الأماكن اللي زي
+
+87
+00:06:39,710 --> 00:06:46,370
+المستشفيات طب كيف اتخلصنا من جثة المستشفيات انه
+
+88
+00:06:46,370 --> 00:06:49,360
+يسيب انتقال؟ فيه انحاء اسم يا بنات؟Infection
+
+89
+00:06:49,360 --> 00:06:54,140
+Control Measures، إجراءات اللي هو منع العدوى، الآن
+
+90
+00:06:54,140 --> 00:06:58,280
+إجراءات منع العدوى مصطلحة عامة لها، مصطلحة عامة،
+
+91
+00:06:58,280 --> 00:07:02,560
+العدوى قد تكون عبر الجلد، قد تكون عبر الإبر، عبر
+
+92
+00:07:02,560 --> 00:07:07,020
+الشاربز، طب لما تكون عبر ال respiratory، فيه إلها
+
+93
+00:07:07,020 --> 00:07:11,030
+إجراءات خاصةفاحنا لو كان في مرض بينتقل عن طريق
+
+94
+00:07:11,030 --> 00:07:15,470
+الجهاز التنفسي، بنقول يلا ابدأوا تطبقوا إجراءات
+
+95
+00:07:15,470 --> 00:07:18,950
+منع العدوى المتعلقة بمين بأمراض الجهاز التنفسي،
+
+96
+00:07:18,950 --> 00:07:23,450
+وفي الحقيقة أنه جابت نتيجة وقللت نسب الإصابة في
+
+97
+00:07:23,450 --> 00:07:26,070
+العاملين في القطاع الصحي اللي بتعاملوا مع مرضى
+
+98
+00:07:26,070 --> 00:07:32,540
+الصارسالان في عندي نقطة تانية انه في animal
+
+99
+00:07:32,540 --> 00:07:36,220
+reservoir animal reservoir ايش يعني animal
+
+100
+00:07:36,220 --> 00:07:40,300
+reservoir؟ يعني في مخازن حيوانية لل coronavirus
+
+101
+00:07:40,300 --> 00:07:45,060
+ويعتقد انه يلها دور كبير في انتقالها لمين؟ للإنسان
+
+102
+00:07:45,060 --> 00:07:50,340
+في حيوانين اتنين رئيسي الخفاش الذي يشبه حدوة
+
+103
+00:07:50,340 --> 00:07:55,070
+الحصار بسموه horseأو shoe horse مش عارف هورس شو
+
+104
+00:07:55,070 --> 00:07:59,470
+هورس شو اللي هو حدوث الحصار بقت هذا ك reservoir
+
+105
+00:07:59,470 --> 00:08:04,330
+natural reservoir وفيه حاسمة civet cat قطة ال
+
+106
+00:08:04,330 --> 00:08:09,410
+civet طبعا هذه القطة تؤكل من قبل الصينين يعني
+
+107
+00:08:09,410 --> 00:08:13,250
+بيبيعوها في الأسواق و بيأكلوها الصينين فبيعتقدوا
+
+108
+00:08:13,250 --> 00:08:16,430
+أنها intermediate host intermediate host يعني هي
+
+109
+00:08:16,430 --> 00:08:22,200
+اللي بتنقلفمعظم الحالات اللي أصيبت originally مش
+
+110
+00:08:22,200 --> 00:08:25,820
+اللي هم موردين من الأطباء كانت أصيبت من من من
+
+111
+00:08:25,820 --> 00:08:30,000
+تناولهم أو تعابلهم مع من مع ال cats مش مع الخفافيش
+
+112
+00:08:30,000 --> 00:08:35,220
+وانما مع هذا النوع من القطط ال coronavirus
+
+113
+00:08:35,220 --> 00:08:39,140
+infection is typically limited to mycosal cells of
+
+114
+00:08:39,140 --> 00:08:43,240
+the respiratory tract يعني بتخترقش إلى أماكن أخرى
+
+115
+00:08:43,240 --> 00:08:48,890
+فقط بتكون في الmycosal cellsحوالي خمسين بالمائة من
+
+116
+00:08:48,890 --> 00:08:53,350
+نسب الإصابة أو من الإصابة بتكون asymptomatic وكلمة
+
+117
+00:08:53,350 --> 00:08:57,510
+asymptomatic يعني ايه؟ يعني مافيش أعراض وانا وانا
+
+118
+00:08:57,510 --> 00:09:03,910
+سؤال هل لهؤلاء ال asymptomatic patients دور في نقل
+
+119
+00:09:03,910 --> 00:09:09,270
+المرض ولا مالهمش دور؟انت على طول قلت اه يعني و
+
+120
+00:09:09,270 --> 00:09:11,970
+احنا قاعدين بقولكوا ان العالم بيقول it is unclear
+
+121
+00:09:11,970 --> 00:09:15,310
+يعني ليس من الواضح و انتوا على طول قفتتوا انه ايه
+
+122
+00:09:15,310 --> 00:09:18,590
+مع ان انا حذرتكم المحاضرة الماضية و قلتلكوا يا
+
+123
+00:09:18,590 --> 00:09:23,970
+جماعة لغة ال science دايما مشككة مشككة و ليست
+
+124
+00:09:23,970 --> 00:09:28,150
+قاطعة بس انتوا طبعا تحبوا تقطعوا الشك باليقين
+
+125
+00:09:32,480 --> 00:09:35,320
+يعني حتى لما بنعمل في فيسبوك يا like يا dislike،
+
+126
+00:09:35,320 --> 00:09:40,180
+مافيش حلول وسط عنها، immunity following infection
+
+127
+00:09:40,180 --> 00:09:45,360
+appears to be brief، brief مانعها قصيرة، يعني
+
+128
+00:09:45,360 --> 00:09:48,480
+المناعة اللي بنحصل عليها بعد العدوى بتكون قصيرة،
+
+129
+00:09:48,480 --> 00:09:52,600
+لذلك multiple infection can occur، يعني بنقدر نصاب
+
+130
+00:09:52,600 --> 00:09:55,660
+بال coronavirus مرارا وتكرار
+
+131
+00:09:59,210 --> 00:10:07,090
+السعر السيئ بالوفيات فيه غالبا الغرق،
+
+132
+00:10:07,090 --> 00:10:12,990
+ماهو رأيكم؟ الإنسان كيف بيغرق؟ بانملع عن الأكسجين،
+
+133
+00:10:12,990 --> 00:10:17,030
+مظبوط؟طبعا لو .. لو .. لو مانعب ال oxygen بال ..
+
+134
+00:10:17,030 --> 00:10:21,230
+بالخنق، لكن هذا لا يخنق، وإنما السوائل will build
+
+135
+00:10:21,230 --> 00:10:25,050
+up in the lungs، فبالتالي هو مانخنقش، هو غرق
+
+136
+00:10:25,050 --> 00:10:28,210
+بالفعل، غرق في اللي هو السوائل اللي موجودة في ال
+
+137
+00:10:28,210 --> 00:10:31,970
+lungs تبعته، وبالتالي صار عنده hypoxia أو نقص في
+
+138
+00:10:31,970 --> 00:10:36,840
+ال oxygen وبالتالي ممكن يموتالـ Clinical finding
+
+139
+00:10:36,840 --> 00:10:39,680
+هو الـ common cold caused by Corona virus is
+
+140
+00:10:39,680 --> 00:10:42,200
+characterized by Choriza Choriza اللي هي الـ runny
+
+141
+00:10:42,200 --> 00:10:46,940
+nose زي ما حكينا، scratchy sore throat، بيكون
+
+142
+00:10:46,940 --> 00:10:51,340
+المريض يلخطر يحقق الحلق طبعه من جوا، ليش؟ لأنه في
+
+143
+00:10:51,340 --> 00:10:54,690
+شعور بالنمنة تماما بالحكةفي الـ sore throat وعلى
+
+144
+00:10:54,690 --> 00:11:00,190
+فكرة هذا common بين الناس ودلأسف بياخدوا
+
+145
+00:11:00,190 --> 00:11:03,990
+antibiotic برضه لعلاج هذا النوع من ال sore throat
+
+146
+00:11:03,990 --> 00:11:09,330
+وهو لا يحتاج وغالبا هتشوفوا ان ال coronavirus are
+
+147
+00:11:09,330 --> 00:11:13,570
+self-limited ومافيش اي يعني consequences او
+
+148
+00:11:13,570 --> 00:11:16,590
+complications لل disease غالبا self-limited بتروح
+
+149
+00:11:16,590 --> 00:11:25,890
+لحالة بدون اي اعراض جانبيالصحيحة تبقى مجموعة
+
+150
+00:11:25,890 --> 00:11:31,470
+أيام وليس لديها
+
+151
+00:11:31,470 --> 00:11:36,830
+أثار طويل على المدى البعيد كورونا فايروس أيضا يسبب
+
+152
+00:11:36,830 --> 00:11:42,230
+برونكايتس صارتز هو نيومونيا عادية وذكرنا عنه قبل
+
+153
+00:11:42,230 --> 00:11:48,090
+قليل ومخصص من حرارة 38 درجة سنتيجريلNon-productive
+
+154
+00:11:48,090 --> 00:11:51,950
+cough مش هي non-productive cough يعني كحة ما بيطلع
+
+155
+00:11:51,950 --> 00:11:55,470
+فيها المريض Sputum تمام؟ بينما ال productive cough
+
+156
+00:11:55,470 --> 00:11:59,870
+بتكون كحة جافة يعني زي dry cough، dyspnea اختناق
+
+157
+00:11:59,870 --> 00:12:03,690
+and هيبوكسيا أو قلنا هيبوكسيا نتج عن ال
+
+158
+00:12:03,690 --> 00:12:06,790
+accumulation لمين؟ لل fluid في ال lungs
+
+159
+00:12:09,510 --> 00:12:13,490
+اللي أنا ما زلت في الفقرة التالية أتحدث عن مين عن
+
+160
+00:12:13,490 --> 00:12:17,710
+ال SARS، chills, rigors, malaise and headache
+
+161
+00:12:17,710 --> 00:12:23,370
+commonly occur، but sore throat and rhinorrhea are
+
+162
+00:12:23,370 --> 00:12:27,170
+uncommon، يعني إن يكون فيه runny nose وإن يكون فيه
+
+163
+00:12:27,170 --> 00:12:30,070
+التهيبات في الحلق، بتكونش common في مين؟ في ال
+
+164
+00:12:30,070 --> 00:12:34,490
+SARS، ال SARS أكتر شكل النيومونيا، بينما ال other
+
+165
+00:12:34,490 --> 00:12:37,690
+coronavirus بتكون upper respiratory tract
+
+166
+00:12:37,690 --> 00:12:41,040
+infectionفي الـ SARS أيضًا بيكون في انديليوكوبينيا
+
+167
+00:12:41,040 --> 00:12:43,560
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+168
+00:12:43,560 --> 00:12:43,620
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+169
+00:12:43,620 --> 00:12:44,640
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+170
+00:12:44,640 --> 00:12:44,760
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+171
+00:12:44,760 --> 00:12:44,800
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+172
+00:12:44,800 --> 00:12:44,860
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+173
+00:12:44,860 --> 00:12:45,020
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+174
+00:12:45,020 --> 00:12:45,480
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+175
+00:12:45,480 --> 00:12:49,380
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+176
+00:12:49,380 --> 00:12:53,260
+و .. و
+
+177
+00:12:53,260 --> 00:12:55,980
+.. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+178
+00:13:04,260 --> 00:13:07,840
+وقت محدد، تلت أيام، أربع أيام، خمس أيام، ماعنديش
+
+179
+00:13:07,840 --> 00:13:14,940
+بنقول ده من ال range بس الجرعة
+
+180
+00:13:14,940 --> 00:13:18,740
+اللي هي ال dos بالإضافة إلى مين؟ إلى اللي هو ال
+
+181
+00:13:18,740 --> 00:13:22,660
+immunity وهل أصلا في previous contact مع ال virus
+
+182
+00:13:22,660 --> 00:13:25,340
+ولا مافيش previous contact مع ال virus؟ هذا فيه
+
+183
+00:13:25,340 --> 00:13:28,780
+كثير من الأحيان، لكن في أحيان أخرى الأمر مرتبط
+
+184
+00:13:28,780 --> 00:13:33,560
+ممكن يكون بعامل أخرى، مثلاالـ rabies اللي حدثه
+
+185
+00:13:33,560 --> 00:13:40,400
+لاحقا في هذا الفصل أيضا ال incubation period وظهور
+
+186
+00:13:40,400 --> 00:13:46,640
+الأعراض الرئيسية مرتبط ببعد العضة بتاعة الكلب أو
+
+187
+00:13:46,640 --> 00:13:51,200
+الخفاش أو whatsoever اه او النمر تخيلوا نمر عشان
+
+188
+00:13:51,200 --> 00:13:52,280
+يعمله rabies
+
+189
+00:13:54,910 --> 00:13:59,230
+بعد عن الجهاز العصب المركزي لما بتكون جريبة بيكون
+
+190
+00:13:59,230 --> 00:14:03,310
+فيه فترة incubation قصيرة يعني لو كانت العضة في
+
+191
+00:14:03,310 --> 00:14:06,390
+مكان في الرقب أو في الكتف أو في مكان في الرأس
+
+192
+00:14:06,390 --> 00:14:11,210
+بتكون بسرعة تحدث اللي هو الأعراض تدهور بسرعة لكن
+
+193
+00:14:11,210 --> 00:14:16,050
+لو كانت بعيدة مثلا في الساق هذا بيعطي فترة أطول لل
+
+194
+00:14:16,050 --> 00:14:18,470
+incubation period إذا ال incubation period في
+
+195
+00:14:18,470 --> 00:14:21,750
+مجموعة عوام اللي قد تؤثر عليها نوع ال microbe
+
+196
+00:14:22,360 --> 00:14:25,260
+المايكروب بتاعي فيه اختلافات فيه شي 7 على 10 ايام
+
+197
+00:14:25,260 --> 00:14:31,460
+فيه 10 على 24 فيه يومين تمام زي ال influenza زي
+
+198
+00:14:31,460 --> 00:14:35,580
+الرشح يعني ال incubation period معتمدة على واحد
+
+199
+00:14:35,580 --> 00:14:39,440
+نوع المايكروب اتنين الجرعة تلاتة المناعة ال site
+
+200
+00:14:39,440 --> 00:14:44,060
+of entry مكان دخول اللي هو ال virus او ال مايكروب
+
+201
+00:14:47,130 --> 00:14:49,710
+الـ diagnosis of the common cold is made clinical،
+
+202
+00:14:49,710 --> 00:14:52,410
+و للأسف لما أستطيع بالـ clinical diagnosis أنني
+
+203
+00:14:52,410 --> 00:14:54,990
+أتميز أن هذا رينوفيروس ولا كورونافيروس ولا
+
+204
+00:14:54,990 --> 00:14:58,930
+أدينوفيروس ولا رسبراتوريس انسيتيل ولا بعرع
+
+205
+00:14:58,930 --> 00:15:01,650
+انفلوانذافارات، مقدرش أنني أتميز بينهم، ولكن بنقول
+
+206
+00:15:01,650 --> 00:15:07,370
+common coldلحظوا ال common cold كلهم self-limited
+
+207
+00:15:07,370 --> 00:15:10,910
+ولا واحد من اللي احنا درسناهم في بيعمل ايه له
+
+208
+00:15:10,910 --> 00:15:14,410
+complications وبتالي بس لو احنا جولنا common cold
+
+209
+00:15:14,410 --> 00:15:19,110
+وشخصنا صح انتهى الموضوع سواء راحة انتهى او انتهت
+
+210
+00:15:19,110 --> 00:15:23,810
+الجثة في هذا الموضوع لكن اذا SARS لا نكتفي بال
+
+211
+00:15:23,810 --> 00:15:26,930
+clinical diagnosis لازم يكون فيه انها antibody
+
+212
+00:15:26,930 --> 00:15:33,830
+based test او PCR based testبالتعليم والتحقيق، لا
+
+213
+00:15:33,830 --> 00:15:38,210
+يوجد
+
+214
+00:15:38,210 --> 00:15:44,950
+علاج أو تطييب لهذا الفيروس، لكن في محاولة أجريت
+
+215
+00:15:44,950 --> 00:15:48,210
+باستخدام الريبافرين، وريبافرين هيثار مر معانا كتير
+
+216
+00:15:48,210 --> 00:15:53,090
+في هذا الفصل أو في هذا ال chapter يعني أقصد،
+
+217
+00:15:53,090 --> 00:15:56,590
+الريبافرين بالإضافة إلى الستيرويتس كانوا يحاولوا
+
+218
+00:15:56,590 --> 00:16:03,290
+في التعليم للحياةLife-threatening cases يعني حالات
+
+219
+00:16:03,290 --> 00:16:09,170
+مهددة للحياة و التالي المحاولة بأي شيء قد يعني
+
+220
+00:16:09,170 --> 00:16:15,210
+تساعد but their efficacy is uncertain للجماعة اللي
+
+221
+00:16:15,210 --> 00:16:20,510
+على طول بيفتو ان اه او لا احنا كل مرة بنقولكوا على
+
+222
+00:16:20,510 --> 00:16:25,190
+الرغم من المحاولات انه مش جادرين نحدد هل بالفعل ال
+
+223
+00:16:25,190 --> 00:16:29,180
+effectiveness تبعها عالي ولا منخفضهل في المستقبل
+
+224
+00:16:29,180 --> 00:16:33,240
+نعتمد هذا النوع من الهلاجة ولا لأ؟ ليش ال
+
+225
+00:16:33,240 --> 00:16:37,460
+uncertainty موجودة؟ هل احنا بنحب انه دائما نكون
+
+226
+00:16:37,460 --> 00:16:43,520
+مشككين؟ همنحبش نكون مشككين، لكن عدد المرضى اللي
+
+227
+00:16:43,520 --> 00:16:46,780
+اتعاملنا معاهم على سبيل المثال بيكون قليلالـ
+
+228
+00:16:46,780 --> 00:16:50,760
+outcome اللي طلعت ال percentage اللي طلعت اشي منهم
+
+229
+00:16:50,760 --> 00:16:54,220
+اكترين بالمية okay اكترين و تلاتين بالمية مش okay
+
+230
+00:16:54,220 --> 00:16:58,120
+يعني بمعنى بمعنى اخر انه مش قادر احصل على نتيجة
+
+231
+00:16:58,120 --> 00:17:02,140
+conclusive حاسمة تقول ان والله هذا treatment is
+
+232
+00:17:02,140 --> 00:17:05,990
+effectiveوبيكونوا يتذكروا أن أي استيرويد تُعطى
+
+233
+00:17:05,990 --> 00:17:08,950
+للبنادمين لازم تُعطى بحدها، لأن احنا أصلا مش
+
+234
+00:17:08,950 --> 00:17:13,090
+فاهمين بالضبط كيف الاستيرويد تشتغل، بتعمل عاصفة في
+
+235
+00:17:13,090 --> 00:17:20,230
+الجسم، وبيستفيد الجسم في بعض الأحيانلكن دائما و
+
+236
+00:17:20,230 --> 00:17:25,210
+أبدا هناك مضار من استخدام الاستيرايد تمام؟ فبرضه
+
+237
+00:17:25,210 --> 00:17:30,130
+مش لازم نستخدم الاستيرايد إلا بحضر و under control
+
+238
+00:17:30,130 --> 00:17:34,350
+لازم يكون الأطباء موجودين و يشوفوا إيش ممكن يصير
+
+239
+00:17:34,350 --> 00:17:39,770
+فيه مضاعفة الفيروس التالي في السلسلة خلصنا كورونا
+
+240
+00:17:39,770 --> 00:17:43,270
+فيروس الآن نتكلم عالميا عن روبيلا لحظة روبيلا
+
+241
+00:17:43,270 --> 00:17:48,220
+ارتبط اسمه بال missiles و بالممصص صح؟الميسلز
+
+242
+00:17:48,220 --> 00:17:54,540
+والمامس تبين لمين؟ بالبارا مايوكسي هذا مالوش علاقة
+
+243
+00:17:54,540 --> 00:17:58,080
+.. هذا مالوش علاقة فيهم على الرغم من ان هم التلات
+
+244
+00:17:58,080 --> 00:18:03,920
+مالهم في نفس ال vaccine ولاحظوا disease missiles و
+
+245
+00:18:03,920 --> 00:18:08,420
+german missiles وكلاهما .. كلاهما بيحدثوا تقريبا
+
+246
+00:18:08,420 --> 00:18:13,400
+نفس المرض لكن بينتموا إلى عائلات وتركيبات مختلفة
+
+247
+00:18:13,400 --> 00:18:18,580
+البارا مايوكسي فيروس ابناتnegative sins هذا
+
+248
+00:18:18,580 --> 00:18:23,020
+positive sins نعم تواجه فيروس بيختلف تماما عن ال
+
+249
+00:18:23,020 --> 00:18:27,480
+Paramyoxic virus هادلاك كانوا helical هادي
+
+250
+00:18:27,480 --> 00:18:32,580
+eicosahedral إذا في اختلاف بينهم على الرغم من أنهم
+
+251
+00:18:32,580 --> 00:18:37,610
+بيسببوا تقريبا أمراض شبيهة بعضها البعضالفيروس يسبب
+
+252
+00:18:37,610 --> 00:18:41,470
+فيه اتجارات اتجارات اتجارات اتجارات اتجارات
+
+253
+00:18:41,470 --> 00:18:42,990
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+254
+00:18:42,990 --> 00:18:44,630
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+255
+00:18:44,630 --> 00:18:48,450
+اتجارات اتجارات اتجارات اتجارات
+
+256
+00:18:48,450 --> 00:18:50,250
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+257
+00:18:50,250 --> 00:18:50,310
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+258
+00:18:50,310 --> 00:18:50,710
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+259
+00:18:50,710 --> 00:18:55,310
+اتجارات اتجارات اتجارات
+
+260
+00:18:55,310 --> 00:18:56,190
+اتجارات
+
+261
+00:19:00,790 --> 00:19:04,250
+Cytomegalovirus الان اذا بتذكروا الجملة ايش بتقول
+
+262
+00:19:04,250 --> 00:19:08,830
+ان ال CMV في اللي درسناها بتقول ان ال CMV is one
+
+263
+00:19:08,830 --> 00:19:12,790
+of the leading causes of congenital abnormality in
+
+264
+00:19:12,790 --> 00:19:15,710
+the united states فمهما بيعمل congenital
+
+265
+00:19:15,710 --> 00:19:20,530
+abnormality تذكروا ان ال CMV مايوجدوش vaccine هدا
+
+266
+00:19:20,530 --> 00:19:23,530
+اله vaccine ال vaccine عمل reduction
+
+267
+00:19:26,140 --> 00:19:30,420
+للحالات الربلة بشكل عام وبالتالي عمل reduction
+
+268
+00:19:30,420 --> 00:19:34,020
+لحالات ايضا ال congenital rebel اذا احنا خفضنا
+
+269
+00:19:34,020 --> 00:19:37,080
+الربلة العادية وبالتالي خفضنا ايضا مين اللي هو ال
+
+270
+00:19:37,080 --> 00:19:42,120
+congenital abnormal ال
+
+271
+00:19:42,120 --> 00:19:45,100
+characteristics بتاعة الفيروس هنا toga virus قلنا
+
+272
+00:19:45,100 --> 00:19:51,620
+هو مش بعلم يكسي ولا كورونا هو toga virusone piece
+
+273
+00:19:51,620 --> 00:19:56,100
+of a single-stranded RNA eicosahedral nucleocapsid
+
+274
+00:19:56,100 --> 00:19:58,660
+and a lipoprotein envelope يعني برضه still
+
+275
+00:19:58,660 --> 00:20:01,980
+envelope لإن احنا أصلا عنوانها ماتنسوش RNA
+
+276
+00:20:01,980 --> 00:20:08,340
+enveloped virus على النقيض ال paramyoxiv viruses
+
+277
+00:20:08,340 --> 00:20:12,280
+زي الميسلز والممس اللي هم اخوتوه في ال vaccine مش
+
+278
+00:20:12,280 --> 00:20:17,110
+في الرضاعة اخوتوه في ال vaccineit has a positive
+
+279
+00:20:17,110 --> 00:20:20,510
+-stranded RNA، يعني مع الحاجة اللوتانية الشمالهم،
+
+280
+00:20:20,510 --> 00:20:24,510
+negative-stranded RNA، and therefore it has no
+
+281
+00:20:24,510 --> 00:20:29,110
+virion polymerase، بينما الميسلز والمامس كانوا
+
+282
+00:20:29,110 --> 00:20:32,630
+بيحتاجوا RNA dependent، RNA polymerase يكون معاهم
+
+283
+00:20:32,630 --> 00:20:37,360
+في ال virus particleالـ spikes بتحتوي على
+
+284
+00:20:37,360 --> 00:20:42,680
+hemagglutinin، single antigenic type، سر نجاحنا في
+
+285
+00:20:42,680 --> 00:20:46,960
+الفاكسين، ان one single serotype وان ال human are
+
+286
+00:20:46,960 --> 00:20:52,480
+the only natural host for this virus، و ال
+
+287
+00:20:52,480 --> 00:20:56,580
+antibody directed against hemagglutinin
+
+288
+00:20:56,580 --> 00:21:00,560
+neutralizes infectivity، و أنا بالدجاج عندها دي
+
+289
+00:21:00,560 --> 00:21:09,700
+نقطة نظامneutralizes infectivity ما بتعني لكم ان
+
+290
+00:21:09,700 --> 00:21:14,880
+الفيروس هي عنده hemagglutinin اذا الانتيبادرتبط
+
+291
+00:21:14,880 --> 00:21:20,260
+فيه منعه انه يعمل infection للخلايا ممتاز قليلة
+
+292
+00:21:20,260 --> 00:21:25,860
+عمره جيد في كل مرة وان في مرة ماكانش جيد
+
+293
+00:21:29,790 --> 00:21:33,770
+في ال respiratory syncytial virus فاكرين؟ المرض
+
+294
+00:21:33,770 --> 00:21:37,430
+أصلا كان ناتج عن مين؟ عن ارتباط على الرغم من أنه
+
+295
+00:21:37,430 --> 00:21:41,650
+بالفعل ال antibody عمل neutralizers لل infectivity
+
+296
+00:21:41,650 --> 00:21:45,930
+of the virus لكن ال disease كان ناتج عن الارتباط
+
+297
+00:21:45,930 --> 00:21:48,690
+هذا لأنه عمل activation لل complement عمل
+
+298
+00:21:48,690 --> 00:21:52,890
+destruction لل lungs cells جمعت ال immune system
+
+299
+00:21:52,890 --> 00:21:57,370
+برضه عمل destruction إضافي لل lungsإذا كلمة
+
+300
+00:21:57,370 --> 00:22:02,930
+neutralizes infectivity معناها واحد بأن الفيروس لم
+
+301
+00:22:02,930 --> 00:22:09,750
+يعد قادرا على إصابة الخلايا ومن ثم تكاثر لكن هذا
+
+302
+00:22:09,750 --> 00:22:14,110
+لا يعني أنه بالضرورة أنه .. أنه كويس، عايشوفنا مرة
+
+303
+00:22:14,110 --> 00:22:18,030
+كويس في هذا الحالة تمام؟ ومرة مش كويس في حالة مين؟
+
+304
+00:22:18,030 --> 00:22:19,970
+ال respiratory syncytial virus
+
+305
+00:22:24,190 --> 00:22:27,710
+The virus is transmitted via respiratory droplets
+
+306
+00:22:27,710 --> 00:22:31,550
+كل يوم جاعدين نتأكد .. نتأكد و بنأكد الحقيقة اللي
+
+307
+00:22:31,550 --> 00:22:36,710
+ذكرناها ان ال enveloped viruses تنار غالبا فيروسات
+
+308
+00:22:36,710 --> 00:22:40,130
+حساسة و بدها close contact و غالبا ال respiratory
+
+309
+00:22:40,130 --> 00:22:44,250
+او sexual contact هو ال mean of ال transmission او
+
+310
+00:22:44,250 --> 00:22:45,830
+ال direct transmission
+
+311
+00:22:47,950 --> 00:22:51,870
+إذن في طريقتين للانتقال إما Transplacental من الأم
+
+312
+00:22:51,870 --> 00:22:55,690
+إلى الجنين أو عبر الrespiratory droplets. The
+
+313
+00:22:55,690 --> 00:22:59,810
+disease is worldwide. In areas where the vaccine
+
+314
+00:22:59,810 --> 00:23:03,550
+is not used, epidemics occur every six to nine
+
+315
+00:23:03,550 --> 00:23:06,610
+years. المثال اللي ذكرناه قبل قليل، قلنا لكم إنه
+
+316
+00:23:06,610 --> 00:23:11,010
+كل ست إلى تسع سنوات بيحدث اللي هو التفشي أو
+
+317
+00:23:11,010 --> 00:23:16,780
+الوباء. في ال 2005 ال CDCواللي مابيعوش ال CDC لازم
+
+318
+00:23:16,780 --> 00:23:20,120
+يعرفه هو ال Center for Disease Control في الولايات
+
+319
+00:23:20,120 --> 00:23:22,960
+المتحدة، إله أفرا كثيرة، لكن الفرع الرئيسي فيه
+
+320
+00:23:22,960 --> 00:23:27,640
+Atlanta في الولايات المتحدة، هذا المركز يُعتبر
+
+321
+00:23:27,640 --> 00:23:31,280
+المركز الأول في العالم في مكافحة الأمراض الماضية
+
+322
+00:23:31,830 --> 00:23:35,990
+وين في مرض غريب في العالم بيبعته أفراد من ال CDC
+
+323
+00:23:35,990 --> 00:23:38,810
+عندهم مختبرات متطورة عندهم Epidemiologist عندهم
+
+324
+00:23:38,810 --> 00:23:44,210
+حواسيب عندهم برامج عندهم fund محترم جدا لعملية
+
+325
+00:23:44,210 --> 00:23:47,050
+التعرف على الأمراض المواضية يعني هم ال
+
+326
+00:23:47,050 --> 00:23:51,390
+microbusters هم اللي اللي بيلاحقوا الميكروبات في
+
+327
+00:23:51,390 --> 00:23:55,650
+العالم وخاصة الميكروبات الجديدة أو اللي تظهر حديثة
+
+328
+00:23:56,850 --> 00:23:59,910
+موقعهم جانى بالمعلومات للي بيحب يعني يزيد من أي
+
+329
+00:23:59,910 --> 00:24:03,950
+ميكروب من الميكروبات يعرف عنه أي معلومات بيدخل على
+
+330
+00:24:03,950 --> 00:24:05,930
+ال CDC.gov
+
+331
+00:24:12,260 --> 00:24:16,080
+أنا شخصيا بستفيد منه خاصة في طائع المحاضرات لما
+
+332
+00:24:16,080 --> 00:24:20,240
+بيكون بدي update بدي أرقام جديدة و بدي أعمل محاضرة
+
+333
+00:24:20,240 --> 00:24:24,040
+لناس يعني متخصصين في المجال المعين و بدي أعطيهم
+
+334
+00:24:24,040 --> 00:24:27,860
+أرقام حديثة باخد من ال CDC و من حاسبها ProMed يعني
+
+335
+00:24:27,860 --> 00:24:31,160
+و ال WHO ده هو التلات مصادر الرئيسية اللي باخد
+
+336
+00:24:31,160 --> 00:24:36,600
+منهم معلومات عن الأمراض المؤدمةElimination قررت
+
+337
+00:24:36,600 --> 00:24:42,780
+هذه المؤسسة أن الولايات المتحدة خالية من الروبيلا
+
+338
+00:24:42,780 --> 00:24:49,480
+في 2005 وعزوا هذا الخلو من الروبيلا إلى الاستخدام
+
+339
+00:24:49,480 --> 00:24:53,820
+الواسع لـ Vaccination ProgramAs a result,
+
+340
+00:24:54,560 --> 00:24:58,180
+cytomegalovirus خلصنا من الربلة اللى بتعمل
+
+341
+00:24:58,180 --> 00:25:01,320
+congenital abnormality وبالتالي مين أنصار الأول
+
+342
+00:25:01,320 --> 00:25:04,840
+صار ال cytomegalovirus هو السبب الأول فيه اللى هو
+
+343
+00:25:04,840 --> 00:25:09,320
+ال congenital abnormality برضه بنجر فعندها نقطة
+
+344
+00:25:09,320 --> 00:25:14,260
+صغيرة ونوضح بعض الأمور تسمع بمصطلح changing
+
+345
+00:25:14,260 --> 00:25:19,480
+epidemiology أو تغير الوبائيات تغير الوبائياتأنا
+
+346
+00:25:19,480 --> 00:25:24,400
+بدأ أقولكوا نماذج و هذا من النماذج أو نموذج من
+
+347
+00:25:24,400 --> 00:25:29,900
+النماذج الـ streptococcus pneumonia كانت one of
+
+348
+00:25:29,900 --> 00:25:33,240
+the leading one of the leading causes of
+
+349
+00:25:33,240 --> 00:25:38,500
+meningitis in young children واحد من أهم مسببات
+
+350
+00:25:38,500 --> 00:25:42,120
+التهاب الصحي في العالم فهذه ال pneumonia اشتبعتها
+
+351
+00:25:42,120 --> 00:25:46,340
+worldwide تمام؟ راح العالم عمل vaccine لـ
+
+352
+00:25:46,340 --> 00:25:49,230
+streptococcus pneumoniaلما عملنا فاكسينة لـ
+
+353
+00:25:49,230 --> 00:25:53,170
+Stratococcus pneumonia قلت نسب الإصابة بالـ Otitis
+
+354
+00:25:53,170 --> 00:25:57,050
+Media و بالـ Eye Infection وبالتالي قلت كمان نسب
+
+355
+00:25:57,050 --> 00:26:01,270
+الإصابة بالاتهاب الصحية الآن صار مين الأول؟
+
+356
+00:26:01,270 --> 00:26:04,630
+إشريشيا كولاي يبقى ت .. ت .. لما أنا عملت
+
+357
+00:26:04,630 --> 00:26:09,050
+intervention تغيرت الوبائي اللي صالح مين؟ بصالح؟
+
+358
+00:26:09,050 --> 00:26:10,730
+مع أنه كانت .. ما كانت بالأول اللي هي الـ
+
+359
+00:26:10,730 --> 00:26:13,790
+Stratococcus pneumonia الآن صارت مثلا إشريشيا
+
+360
+00:26:13,790 --> 00:26:19,760
+كولاي يبقىما بنقدرش احنا نبقى نثبتنا المعلومة
+
+361
+00:26:19,760 --> 00:26:24,660
+ونقول ان المسبب الاول هو X اذا صار فيه
+
+362
+00:26:24,660 --> 00:26:29,120
+intervention او صار فيه تغير في الوبائية يعني مثلا
+
+363
+00:26:29,120 --> 00:26:33,180
+انا دايما بقول الجملة دي وانتم اسموتها مرارا ان
+
+364
+00:26:33,180 --> 00:26:37,540
+الأمراض المعدية كانت هي السبب في قتل 53% من سكان
+
+365
+00:26:37,540 --> 00:26:40,440
+العالم او مش كل العالم عفوا من نسبة الوفيات في
+
+366
+00:26:40,440 --> 00:26:44,350
+العالمتلاتة و خمسين بالمية اليوم حصدها جداش تلاتة
+
+367
+00:26:44,350 --> 00:26:47,690
+بالمية هتتغير في الوبائي ولا مش تتغير في الوبائية
+
+368
+00:26:47,690 --> 00:26:51,890
+ملعب السكر كان يصيب فقط من أعمارها من فوق الستين
+
+369
+00:26:51,890 --> 00:26:54,110
+اللي كان بيصيب الشباب اللي عمره عمري و عشرين سنة
+
+370
+00:26:54,110 --> 00:26:56,650
+من النوع التاني لأ لأ من .. هدا كان النوع الأول
+
+371
+00:26:56,650 --> 00:26:59,010
+ممكن اللي هو النوع التاني عشرين و تلاتين و اربعين
+
+372
+00:26:59,010 --> 00:27:01,990
+إذن الوبائي اللي بيبقى ملها تتغير فانا أرجو من
+
+373
+00:27:01,990 --> 00:27:06,590
+حضراتكم تفهم هذا المصطلح ان changing epidemiology
+
+374
+00:27:06,590 --> 00:27:11,630
+او epidemics تمام هذا مرهون بسلوك البشر و بال
+
+375
+00:27:11,630 --> 00:27:14,510
+intervention في ال pollution في ال global warming
+
+376
+00:27:14,510 --> 00:27:19,310
+في شرائط كتيرة في اكتشاف drugs في تعلم حقائق جديدة
+
+377
+00:27:19,310 --> 00:27:23,790
+يعني انا جدناكوا غصل الإيدان انقذ حياة الملايين من
+
+378
+00:27:23,790 --> 00:27:26,850
+الأمهات في المستشفيات في عمليات الولادة لما
+
+379
+00:27:26,850 --> 00:27:30,890
+اتعلموا نصف الإيدان فقط فدائما بدنا نفهم ان
+
+380
+00:27:30,890 --> 00:27:34,690
+الأرقام اللي بنذكرها مش بالضرورة تبقى هي نفس
+
+381
+00:27:34,690 --> 00:27:38,810
+الأرقام اللي اتعلمناها ايامالدراسة قد تتغير و لازم
+
+382
+00:27:38,810 --> 00:27:43,690
+يكون المفهوم لدينا ان هذا التغير مبرر بانه صار فيه
+
+383
+00:27:43,690 --> 00:27:48,710
+intervention من قبل البشر او تغير معين لما عملنا
+
+384
+00:27:48,710 --> 00:27:53,810
+ال vaccine كانت الربيلة رقم واحد في ال congenital
+
+385
+00:27:53,810 --> 00:27:56,270
+abnormality عملنا ال vaccine صار مين ال number
+
+386
+00:27:56,270 --> 00:28:00,310
+one؟ سايتون ميجالو فيروس هذا المقصود في changing
+
+387
+00:28:00,310 --> 00:28:04,570
+epidemiology او تلقاء اللي بيانRubella is a milder
+
+388
+00:28:04,570 --> 00:28:11,550
+يعني أخف shorter فترة المرض أقصر disease than
+
+389
+00:28:11,550 --> 00:28:16,150
+measles دايما بنقارن Rubella بمين بالميسلز after
+
+390
+00:28:16,150 --> 00:28:18,710
+an incubation period of fourteen to twenty one
+
+391
+00:28:18,710 --> 00:28:23,110
+days a brief prodromal period of fever and malaise
+
+392
+00:28:23,110 --> 00:28:27,230
+is followed by maculopapular rashes اللي هو نفس
+
+393
+00:28:27,230 --> 00:28:32,510
+الرش تبع مين؟ الميسلزببدأ برضه بال face و بينتقل
+
+394
+00:28:32,510 --> 00:28:37,810
+الى الجسم و من ثم الى اليدين ايش اختلاف طبعا عن ال
+
+395
+00:28:37,810 --> 00:28:42,970
+missiles اختلاف ايش ايه؟ فيه حد ما ذكرناهاش هنا و
+
+396
+00:28:42,970 --> 00:28:46,690
+ذكرناها في ال missiles مين بتذكرها؟
+
+397
+00:28:50,330 --> 00:28:55,050
+كوبليك سبوت هي الإحمرار اللى موجود فى الـbuccal
+
+398
+00:28:55,050 --> 00:28:58,570
+cavity، النقاط الحمرة، الـspots تمام؟ الحمرة اللى
+
+399
+00:28:58,570 --> 00:29:03,250
+فىها white dots، كمان فىها نقاط بيضاء، قولنا عنها
+
+400
+00:29:03,250 --> 00:29:07,390
+هادي characteristic للميسلز، غير موجود فى مين؟ فى
+
+401
+00:29:07,390 --> 00:29:11,950
+ال German missiles أو فى الربينةPosterior
+
+402
+00:29:11,950 --> 00:29:16,330
+Auricular Lymphadenopathy is characteristics هنا
+
+403
+00:29:16,330 --> 00:29:21,570
+هنا إذا بكتبها في ان روبيللا دائما و أبدا في
+
+404
+00:29:21,570 --> 00:29:25,810
+انتفاخ ورا الأذن هذا معناه لـ posterior auricular
+
+405
+00:29:25,810 --> 00:29:28,810
+lymphadenopathy الانتفاخ هنا نتجة عن ال swelling
+
+406
+00:29:28,810 --> 00:29:33,150
+في ال lymph node الموجودة في المنطقة ورا الأذن هذه
+
+407
+00:29:33,150 --> 00:29:37,090
+ال characteristics وجودها تقريبا وجودها يعني
+
+408
+00:29:37,090 --> 00:29:43,180
+روبيللا مع شوية trash معناها روبيللاوصلت؟ The rash
+
+409
+00:29:43,180 --> 00:29:46,160
+typically lasts for three days، short period، يعني
+
+410
+00:29:46,160 --> 00:29:49,680
+فترة قصيرة، when rubella occurs in adults، لما
+
+411
+00:29:49,680 --> 00:29:53,700
+تصير في الناس البالغين especially women،
+
+412
+00:29:53,700 --> 00:29:57,800
+polyarthritis، ايش يعني polyarthritis؟ كل المفاصل
+
+413
+00:29:57,800 --> 00:30:01,420
+الان في المفاصل بشكل عام، نتيجة عن ايش ال
+
+414
+00:30:01,420 --> 00:30:05,480
+polyarthritis؟ Antigen-antibody complexes،
+
+415
+00:30:05,480 --> 00:30:07,560
+deposition في هذه المفاصل
+
+416
+00:30:10,330 --> 00:30:15,830
+Congenital Rubella Syndrome بيسموها Teratogen أي
+
+417
+00:30:15,830 --> 00:30:21,350
+مُركّب بيأثر على الأجنة بيسميه Teratogen.Pregnant
+
+418
+00:30:21,350 --> 00:30:27,630
+woman is infected during the first trimester.الأول
+
+419
+00:30:27,630 --> 00:30:34,050
+تلت شهور.Especially the first month significant
+
+420
+00:30:34,050 --> 00:30:38,650
+congenital malformation can occur.إذا كان في الشهر
+
+421
+00:30:38,650 --> 00:30:43,930
+الأولأسوأ من الشهر الثاني أسوأ أسوأ من الشهر
+
+422
+00:30:43,930 --> 00:30:47,290
+الثاني يعني بمعنى أخر كل ما اتقدمنا بيخف الضرر لأ
+
+423
+00:30:47,290 --> 00:30:53,110
+بيخف الضرر البداية هي الأسوأ البداية هي الأسوأ the
+
+424
+00:30:53,110 --> 00:30:55,330
+increased rate of abnormalities during the early
+
+425
+00:30:55,330 --> 00:30:58,310
+weeks of pregnancy is attributed to the very
+
+426
+00:30:58,310 --> 00:31:01,350
+sensitive organ development that occurred at that
+
+427
+00:31:01,350 --> 00:31:06,950
+time طبعا انتوا عارفين انه في بداية التكون التخصيب
+
+428
+00:31:06,950 --> 00:31:11,290
+الجنين ال zygoteالانقسام مش بيكون .. بيكون أسرع من
+
+429
+00:31:11,290 --> 00:31:15,470
+البرج، يعني انقسام سريع وهذه مرحلة حساسة wherein
+
+430
+00:31:15,470 --> 00:31:19,590
+organ development starts فلما الفيروس يكون في هذه
+
+431
+00:31:19,590 --> 00:31:23,830
+المرحلة .. تذكروا المقولة طبعتنا الشهيرة أنه كل ما
+
+432
+00:31:23,830 --> 00:31:28,190
+كان العمل كثير، كل ما كان الخطأ كثير فالفيروس
+
+433
+00:31:28,190 --> 00:31:33,910
+بيكون مشط جدا مع هذه أيضا الخلايا وبالتالي بالفعل
+
+434
+00:31:33,910 --> 00:31:40,320
+بيكون الضرر عالي جداإذا هذه المرحلة مرحلة ال organ
+
+435
+00:31:40,320 --> 00:31:44,280
+development، the malformations are widespread يعني
+
+436
+00:31:44,280 --> 00:31:49,240
+مش بتكون في عضو معين، بتكون في أعضاء متنوعة and
+
+437
+00:31:49,240 --> 00:31:52,460
+can involve primarily the heart, the eyes and the
+
+438
+00:31:52,460 --> 00:31:58,320
+brain، إذا في أعضاء مختلفة لكن أهمها بالنسبة لنا
+
+439
+00:31:58,320 --> 00:32:03,020
+اللي هو القلب والعينين والدماغIn addition, some
+
+440
+00:32:03,020 --> 00:32:12,520
+children infected in utero
+
+441
+00:32:12,520 --> 00:32:18,260
+can continue to execrate rubella virus for months
+
+442
+00:32:18,260 --> 00:32:19,640
+following birth
+
+443
+00:32:22,040 --> 00:32:25,760
+إن ولد وكانت أمه مصابة ونقلته الفيروس حتى وان لم
+
+444
+00:32:25,760 --> 00:32:30,700
+يبدو عليه أي أعراض هو نفسه بيكون مصدر للفيروس لعدة
+
+445
+00:32:30,700 --> 00:32:35,390
+أشهر يعني بيعمل secretion لهذا الفيروسبعض الـ
+
+446
+00:32:35,390 --> 00:32:40,730
+congenital shaders يعني المفرزين، يشدوا الفيروس،
+
+447
+00:32:40,730 --> 00:32:44,290
+يعني هم ينتجوا الفيروس، هم يفرزوا الفيروس، هم
+
+448
+00:32:44,290 --> 00:32:47,490
+أسيمتوماتيكيين و ليسوا مالفورماتيين، كل هذا ما
+
+449
+00:32:47,490 --> 00:32:49,810
+حكيناه، قولنا لكوا أنه سواء كان عنده مالفورماتيين
+
+450
+00:32:49,810 --> 00:32:53,570
+أو ما عندهوش، مالفورماتيين ممكن ينتج الفيروس
+
+451
+00:32:53,570 --> 00:32:58,860
+ويعمله spreadand hence can be diagnosed only if
+
+452
+00:32:58,860 --> 00:33:03,560
+the virus is isolated يعني مايقدرش نعرف إنه هذا
+
+453
+00:33:03,560 --> 00:33:08,540
+مصاب إلا إذا احنا جمنا بعازل إيه؟ اللي هو الفيروس
+
+454
+00:33:08,540 --> 00:33:14,220
+و طبعا واحد apparently healthyهل هناك داعي ان
+
+455
+00:33:14,220 --> 00:33:19,140
+نفحصه للروبيلا؟ إلا إذا الأم أظهرت symptoms لمن؟
+
+456
+00:33:19,140 --> 00:33:23,060
+للروبيلا، فبالتالي المولود حتى وإن كان healthy، he
+
+457
+00:33:23,060 --> 00:33:26,740
+should be investigated for جنة اللي هو الروبيلا
+
+458
+00:33:45,680 --> 00:33:53,070
+الأطفال اللي بنولدوا و عندهمإصابة بالروبيلا بيكون
+
+459
+00:33:53,070 --> 00:33:57,550
+عندهم IgM و IgG that can last for longer periods
+
+460
+00:33:57,550 --> 00:34:00,970
+احنا بنلاحظ انه على 6 شهور ل 15 شهر بتختفي ال
+
+461
+00:34:00,970 --> 00:34:05,410
+maternal antibody لها ده ال virus لكن المصابين لأ
+
+462
+00:34:05,410 --> 00:34:10,910
+بيضال عندهم لفترات طويلة ال lab diagnosis روبيلا
+
+463
+00:34:10,910 --> 00:34:14,530
+virus can be grown in cell culture with little
+
+464
+00:34:14,530 --> 00:34:20,440
+cytopathic effect يعني مالهاش CPE واضحعادةً يتم
+
+465
+00:34:20,440 --> 00:34:24,360
+اكتشافها باستخدام قدرتها على الانتفاق مع الـ
+
+466
+00:34:24,360 --> 00:34:30,260
+ECOVIRUS-CPE. إيش هينتفير مع الـ ECOVIRUS-CPE؟ لأن
+
+467
+00:34:30,260 --> 00:34:33,820
+الـ ECOVIRUS يا بنات، هذا إيه اللي هو الـ CPE؟
+
+468
+00:34:33,820 --> 00:34:37,100
+زراعنا عصر الكرشة بيعمل الـ CPE، دايما بيعمل نفس
+
+469
+00:34:37,100 --> 00:34:42,740
+الـ CPEلو زرعت معاه روبيلا بيمنع ال eco virus من
+
+470
+00:34:42,740 --> 00:34:48,380
+انه يعمل CPE فبنتعرف على الربيلا من خلال منعه لل
+
+471
+00:34:48,380 --> 00:34:53,960
+eco virus CPE فسموه interference testإذا كانت
+
+472
+00:34:53,960 --> 00:34:57,960
+روبيلا بياس موجودة في مصطلح الشخص، وكانت مبتدئة في
+
+473
+00:34:57,960 --> 00:35:01,700
+ثلاجة ثقافات، فلا CPE سيظهر عندما تكون الثقافة
+
+474
+00:35:01,700 --> 00:35:04,580
+مصابة بالإنفاق مع إيكو بياس
+
+475
+00:35:11,690 --> 00:35:15,830
+كمان طريقة أخرى في ال diagnosis هو الأنشودة
+
+476
+00:35:15,830 --> 00:35:20,710
+المعروفة صارت أنه الإرتفاع بأربعة أضعاف أو أكثر في
+
+477
+00:35:20,710 --> 00:35:24,190
+مستوى ال antibody ما بين عينة ال acute ما بين عينة
+
+478
+00:35:24,190 --> 00:35:27,370
+اللي هو ال convalescent serum هو المرة المليون
+
+479
+00:35:27,370 --> 00:35:32,170
+جونالكو البعض بيظن أن هذا النوع من الفحصات ليس له
+
+480
+00:35:32,170 --> 00:35:37,790
+أي قيمة للمريض لإله قيمة إله قيمة أنهيعني عملنا
+
+481
+00:35:37,790 --> 00:35:42,330
+confirm للحالة انه سجلناها رقم اتنين انه لو ماصارش
+
+482
+00:35:42,330 --> 00:35:44,750
+فيه increase يا جماعة مانا الحاجة ان المريض ممكن
+
+483
+00:35:44,750 --> 00:35:49,070
+يكون مريض بمرض اخر وبالتالي لازم نبحث عن هذا
+
+484
+00:35:49,070 --> 00:35:52,710
+المرض، اذا to confirm a case is an essential
+
+485
+00:35:52,710 --> 00:35:57,130
+diagnostic requirement for epidemiological reason
+
+486
+00:35:57,130 --> 00:36:01,920
+وممكن for the sake of the patient بعض الأحيانBy
+
+487
+00:36:01,920 --> 00:36:06,540
+observing the presence of IgM antibody in a single
+
+488
+00:36:06,540 --> 00:36:10,560
+acute phase serum sample يعني ال IGG هو اللي بده
+
+489
+00:36:10,560 --> 00:36:14,800
+four fold increase لكن لو دورنا ع ال IgM و طبعا
+
+490
+00:36:14,800 --> 00:36:19,200
+لأن الربلة من الفحوصات اللي لها علاقة بال abortion
+
+491
+00:36:19,570 --> 00:36:24,190
+و بـ Pregnancy ففي غزة هانا لابد انها تكون متوفرة
+
+492
+00:36:24,190 --> 00:36:28,310
+في كل مكان لان احنا شعب بيحب اللي هو يعني مايصيرش
+
+493
+00:36:28,310 --> 00:36:31,730
+عنده abortion و انه يكون عنده يعني او يعرف سبب
+
+494
+00:36:31,730 --> 00:36:34,210
+عشان المرأة القادمة مايصيرش في عندنا abortion
+
+495
+00:36:34,210 --> 00:36:38,190
+الربلة واحدة من مسببات ال abortion و ال congenital
+
+496
+00:36:38,190 --> 00:36:41,910
+abnormality و ربما يكون ال failure في ال IVF اللي
+
+497
+00:36:41,910 --> 00:36:45,330
+هي زراعة الجنة in vitro
+
+498
+00:36:48,360 --> 00:36:51,640
+In a pregnant woman exposed to rubella virus, the
+
+499
+00:36:51,640 --> 00:36:54,980
+presence of IgM antibody indicates recent
+
+500
+00:36:54,980 --> 00:36:55,420
+infection
+
+501
+00:37:03,110 --> 00:37:07,690
+Whereas one to eight or greater titers of IgG
+
+502
+00:37:07,690 --> 00:37:11,150
+antibody indicates immunity and consequent
+
+503
+00:37:11,150 --> 00:37:16,030
+protection of the fetus يعني لو لجينا عند السيدة
+
+504
+00:37:16,030 --> 00:37:21,230
+تائتر من IgG واحد ل تمانية تمام واحد على تمانية
+
+505
+00:37:21,230 --> 00:37:24,910
+يعني احنا بيقولكوا واحد نص ربع تمان واحد على ستاشر
+
+506
+00:37:24,910 --> 00:37:27,810
+واحد اتنين و تلاتين اذا لجينا واحد على تمانية او
+
+507
+00:37:27,810 --> 00:37:30,130
+اقل اللي هو واحد على ستاشر او واحد على
+
+508
+00:37:33,550 --> 00:37:39,910
+السيدة لديها انتباد كافي وبالتالي هي محافظة من أن
+
+509
+00:37:39,910 --> 00:37:42,070
+تنصب بي الربان
+
+510
+00:37:47,190 --> 00:37:50,130
+أمينو سنتسيز امينو سنتسيز اللي هو الحصول على
+
+511
+00:37:50,130 --> 00:37:55,510
+السائل الجنيني سائل الجنيني can reveal whether
+
+512
+00:37:55,510 --> 00:37:58,490
+there is a rubella virus in the amniotic fluid
+
+513
+00:37:58,490 --> 00:38:03,110
+which indicate definite fetal infection كلمة fetal
+
+514
+00:38:03,110 --> 00:38:07,370
+infection يعني الإصارة في الجنين سوف تؤكد من خلال
+
+515
+00:38:07,370 --> 00:38:14,860
+هذا الفحص طبعا هذا أيضا يعني برضه فحص جيدلان احنا
+
+516
+00:38:14,860 --> 00:38:18,960
+بنعرف ان الطفل مصاب او غير مصاب قبل حتى قبل خروجه
+
+517
+00:38:18,960 --> 00:38:24,920
+الى الحياة treatment there is no antiviral therapy
+
+518
+00:38:24,920 --> 00:38:28,880
+ال prevention involves immunization with live
+
+519
+00:38:28,880 --> 00:38:32,120
+attenuated vaccine كلكم عارفين ان هو جزء من مين؟
+
+520
+00:38:32,120 --> 00:38:37,740
+من طلعة اللي هو ال MMA produces at least 10 years
+
+521
+00:38:37,740 --> 00:38:42,310
+of immunity بعطينا عشرة سنوات تقريبا من المنامIt
+
+522
+00:38:42,310 --> 00:38:46,650
+is given subcutaneously to children at 15 months
+
+523
+00:38:46,650 --> 00:38:49,790
+of age و احنا ذكرنا ليش 15 month لأنه بيقولنا لكوا
+
+524
+00:38:49,790 --> 00:38:52,490
+ان ال .. ال .. ال maternal antibody بتكون موجودة و
+
+525
+00:38:52,490 --> 00:38:56,490
+protective ليدا الطفل It is also given to
+
+526
+00:38:56,490 --> 00:39:00,470
+unimmunized young adult women if they are not
+
+527
+00:39:00,470 --> 00:39:05,690
+pregnant يعني مش خلال الحمل و انما قبل الحملand
+
+528
+00:39:05,690 --> 00:39:09,310
+will use contraceptive for the next three months
+
+529
+00:39:09,310 --> 00:39:13,270
+يعني مضمون إنها ما تحملش كمان تلت شهور، تمام؟ يعني
+
+530
+00:39:13,270 --> 00:39:17,930
+بدناش نعطيها ال vaccine و تحمل بكرا أو تحمل
+
+531
+00:39:17,930 --> 00:39:22,170
+الأسبوع اللي جاي، ليش؟ لأنه لسه .. لأن هذا live
+
+532
+00:39:22,170 --> 00:39:26,670
+attenuated ال virus، صح؟ هممكن ننتقل لمين؟ للجنين
+
+533
+00:39:26,670 --> 00:39:31,470
+اللي عملنا real infectionلا يوجد اي اثبات ان
+
+534
+00:39:31,470 --> 00:39:38,870
+الفيروس يسبب فيه مالفورميشن، لكن للخشية والنظرية
+
+535
+00:39:38,870 --> 00:39:42,430
+اللي بنالكوا عنها لما اتكلمنا عن ال live vaccine و
+
+536
+00:39:42,430 --> 00:39:45,550
+ال killed vaccine ابنها، احد المخاوف اللي ذكرناها
+
+537
+00:39:45,550 --> 00:39:49,450
+ان ال live ال attenuated is to revert to the
+
+538
+00:39:49,450 --> 00:39:53,620
+active formهذه مخاوف نظرية لم نراها إلا أظن مرة
+
+539
+00:39:53,620 --> 00:39:58,280
+واحدة في ال polio vaccine وقلنا لكوا يعني هذا ممكن
+
+540
+00:39:58,280 --> 00:40:02,320
+تخيل احنا بنحتفل قاعدين انه انتهينا من مين؟ من ال
+
+541
+00:40:02,320 --> 00:40:07,060
+polio و بعدين نرجع مرة تانية ل polio disease
+
+542
+00:40:09,730 --> 00:40:12,170
+Because it is a live vaccine, it should not be
+
+543
+00:40:12,170 --> 00:40:14,770
+given to immunocompromised patients or to pregnant
+
+544
+00:40:14,770 --> 00:40:18,050
+women. The vaccine has caused a significant
+
+545
+00:40:18,050 --> 00:40:21,290
+reduction in the incidence of both rubella and
+
+546
+00:40:21,290 --> 00:40:23,490
+congenital rubella syndrome
+
+547
+00:40:29,490 --> 00:40:35,850
+It induces respiratory IgA و احنا قلنا لكم ان ال
+
+548
+00:40:35,850 --> 00:40:40,950
+IgA كتير مهم في هذا النوع من الفيروسات لان معظم ال
+
+549
+00:40:40,950 --> 00:40:44,690
+transmission بيتم عبر اللي هو ال respiratory tract
+
+550
+00:40:44,690 --> 00:40:48,890
+Immune serum globulin can be given to pregnant
+
+551
+00:40:48,890 --> 00:40:51,990
+women in the first trimester who have been exposed
+
+552
+00:40:51,990 --> 00:41:00,540
+to a known case of rubellaسيدة حامل و راحت زهرت
+
+553
+00:41:00,540 --> 00:41:03,660
+جديبتها
+
+554
+00:41:03,660 --> 00:41:09,340
+صاحبتها واكتشفت ان صاحبتها اصلا عندها حصب علماني
+
+555
+00:41:09,340 --> 00:41:14,040
+او تعارض لابنت صاحبتها او ابن صاحبتها المصاب من
+
+556
+00:41:14,040 --> 00:41:18,360
+بالربل يعني ايش معناه؟ ايش .. ايش .. ايش هي وضعها؟
+
+557
+00:41:18,360 --> 00:41:25,820
+exposed صارت هي معرضة و حاملبنجرش نعطيها فاكسين؟
+
+558
+00:41:25,820 --> 00:41:28,460
+نجرش نعطيها فاكسين، إيش مانعطيها في هذه الحالة؟
+
+559
+00:41:28,460 --> 00:41:33,060
+immunoglobulin تمام؟ to protect her and to protect
+
+560
+00:41:33,060 --> 00:41:35,320
+her baby في هذه الحالة
+
+561
+00:41:39,330 --> 00:41:42,330
+Immune serum globulin can be given to pregnant
+
+562
+00:41:42,330 --> 00:41:45,250
+women in the first trimester who have been exposed
+
+563
+00:41:45,250 --> 00:41:49,250
+to a known case of rubella and for whom
+
+564
+00:41:49,250 --> 00:41:53,750
+termination of pregnancy is not an option.طبعا
+
+565
+00:41:53,750 --> 00:41:59,230
+انتوا عارفين الإجهاد عند الأجانب في بعض الدول
+
+566
+00:41:59,230 --> 00:42:02,090
+مشروعة يعني هو مرتبط أنه يحصل فيه إجهاد حتى لو
+
+567
+00:42:02,090 --> 00:42:06,390
+بناها توقع تمام فبيقولك انه في حالة انه
+
+568
+00:42:12,200 --> 00:42:20,660
+المشكلة الرئيسية في الـ immunoglobulin هي أن هناك
+
+569
+00:42:20,660 --> 00:42:26,180
+حاجة فيها التي لا تنجح لإيقاف التأثير الفيطاليعلى
+
+570
+00:42:26,180 --> 00:42:30,820
+الرغم من النجاحات اللي حققها إلا إن هناك حالات فشل
+
+571
+00:42:30,820 --> 00:42:38,160
+ال immunoglobulin أن يحدث منأ للإصابة بال fetal أو
+
+572
+00:42:38,160 --> 00:42:41,740
+ال congenital rebel، إذا مش hundred percent
+
+573
+00:42:45,600 --> 00:43:02,140
+الجملة الأخيرة أو الفقرة الأخيرة تخيلوا
+
+574
+00:43:02,140 --> 00:43:06,280
+للممرض و لطبيب عنده Rubella و خاصة في النساء
+
+575
+00:43:06,280 --> 00:43:11,080
+والولادةاللي بيرجعوا عندهم النساء والحيوانات،
+
+576
+00:43:11,080 --> 00:43:15,680
+مشكلة كبيرة لو ده لأ، لذلك إيش سياسة المستشفى؟
+
+577
+00:43:15,680 --> 00:43:20,780
+سياسة المستشفى إنه لازم يجيب شهادة إنه مطعم أو فحص
+
+578
+00:43:20,780 --> 00:43:24,660
+إنه بيحتوي على اللي هو immunoglobulin بشكل عالي،
+
+579
+00:43:24,660 --> 00:43:30,460
+إنه protectedعشان برضه نمنع اللى هو او نكسر ال
+
+580
+00:43:30,460 --> 00:43:34,820
+cycle اللى ممكن تؤدي الى انتقاد ال virus من ال
+
+581
+00:43:34,820 --> 00:43:38,340
+personnel الى ال .. ال .. ال .. النساء الى حوالى
+
+582
+00:43:38,340 --> 00:43:41,580
+المرة الجاية ان شاء الله بنكمل الفقرات اللى باقية
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..1075c35dab57acffa6e9050d62a5c340a8cc3c86
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/bH1FYc3fHho_raw.srt
@@ -0,0 +1,2328 @@
+1
+00:00:20,970 --> 00:00:24,870
+بسم الله الرحمن الرحيم نكمل RNA-Enveloped Viruses
+
+2
+00:00:24,870 --> 00:00:28,150
+اليوم أو المحاضرة السابقة انتهينا من ال
+
+3
+00:00:28,150 --> 00:00:31,590
+Paramyoxivirus دي اللي شملت مجموعة من الفيروسات زي
+
+4
+00:00:31,590 --> 00:00:34,970
+ال missiles و ال mumps و ال para influenza و ال
+
+5
+00:00:34,970 --> 00:00:39,670
+respiratory syncytial virus و بدأنا بمقدمة بسيطة
+
+6
+00:00:39,670 --> 00:00:42,810
+عن الكورونا فيروس و كنا الكورونا فيروس لم تكن
+
+7
+00:00:42,810 --> 00:00:49,840
+مشهورةقبل 2002 يعني انشهرت بعد ظهور مرض ال SARS
+
+8
+00:00:49,840 --> 00:00:54,140
+وازدادت شهرتها بعد قبل سنتين عند ظهور جونا ال
+
+9
+00:00:54,140 --> 00:00:58,420
+middle east respiratory syndrome هو ال ميرس كورونا
+
+10
+00:00:58,420 --> 00:01:05,120
+في الخليج العربياللي هي واحدة من أهم مسببات ال
+
+11
+00:01:05,120 --> 00:01:09,480
+common cold يعني تالي في الأهمية ال rhinovirus
+
+12
+00:01:09,480 --> 00:01:12,760
+وزمان ما ذكرنالكم في 2002 تم اكتشاف اللي هو
+
+13
+00:01:12,760 --> 00:01:18,260
+atypical pneumonia بفيروس لما شرحنا الفيروس
+
+14
+00:01:18,260 --> 00:01:24,770
+ودرسناه لجينا هو coronavirusشكلًا و تركيبًا لكن ال
+
+15
+00:01:24,770 --> 00:01:27,870
+sequence analysis زي ما ذكرنا في المحاضرة السابقة
+
+16
+00:01:27,870 --> 00:01:32,630
+ال sequence analysis لل DNA لل coronavirus لجنة
+
+17
+00:01:32,630 --> 00:01:36,490
+مختلفة عن ال other .. عفوا لل SARS لجنة مختلفة عن
+
+18
+00:01:36,490 --> 00:01:39,810
+ال other coronavirus لكن ال isolates of
+
+19
+00:01:39,810 --> 00:01:44,990
+coronaviruses أعطتنا similar sequence أو DNA
+
+20
+00:01:44,990 --> 00:01:49,730
+sequence هذا مؤشر على ايه؟على انه التركيب تبع ال
+
+21
+00:01:49,730 --> 00:01:53,590
+.. ال .. ال .. ال SARS viruses او strains شبيه
+
+22
+00:01:53,590 --> 00:01:58,690
+وبالتالي التوقع كان ان ال antigen تبعهم يكون واحد
+
+23
+00:01:58,690 --> 00:02:02,750
+ويكون stable كمان يكون stable زي ما ذكرنا في أحد
+
+24
+00:02:02,750 --> 00:02:10,230
+اللوحات نعمانا عندى لان corona viruses واحد منهم
+
+25
+00:02:10,230 --> 00:02:15,370
+اتشفناه جديد اسمه SARS شكلا و مضمونا بيشبه بيشبه
+
+26
+00:02:15,370 --> 00:02:18,210
+ال other corona viruses تمام؟ لكن لما عملنا
+
+27
+00:02:18,210 --> 00:02:21,370
+sequence analysis لل SARS virus اللي جدا بيختلف
+
+28
+00:02:21,370 --> 00:02:25,550
+بشكل كبير عن اللي هو مين عن ال other corona virus
+
+29
+00:02:25,550 --> 00:02:30,420
+لان ال SARS برضه انا عزل منه اكتر من عزلةلما جينا
+
+30
+00:02:30,420 --> 00:02:33,540
+عملنا sequence analysis لل سارس المختلفة لجيناهم
+
+31
+00:02:33,540 --> 00:02:36,980
+بيشبهوا بعض إلى حد كبير فتوقعنا ان يكون ال antigen
+
+32
+00:02:36,980 --> 00:02:40,980
+تبعهم ان يكون one ويكون stable هذا ال antigen هذا
+
+33
+00:02:40,980 --> 00:02:45,780
+الفكرة كانت فيه اللي هو الحديث تبعنا من المميزات
+
+34
+00:02:45,780 --> 00:02:48,340
+لل Corona فيها تقولنا اللي هو ال club shape spikes
+
+35
+00:02:48,340 --> 00:02:50,740
+اللي الكبيرة هذه اللي شايفينها تبعها و الشكل
+
+36
+00:02:50,740 --> 00:02:56,850
+الجميل اللي اعطاها شكل اللي هو ال Coronaوزي
+
+37
+00:02:56,850 --> 00:02:59,490
+الاخرين اللي متحدثناه ان هو بينتقل عنبر اللي هو ال
+
+38
+00:02:59,490 --> 00:03:03,170
+respiratory to aerosols و ال infection can occur
+
+39
+00:03:03,170 --> 00:03:06,170
+worldwide انا دلوقتي اخدوا بالكوا في ال .. في ال
+
+40
+00:03:06,170 --> 00:03:09,470
+chapter هذا فيه هيصير فيه mixed up شوية مرة اتكلم
+
+41
+00:03:09,470 --> 00:03:13,690
+عن ال stars بخص .. بخصوصية و مرة اتكلم عن مين عن
+
+42
+00:03:13,690 --> 00:03:17,050
+ال coronavirus عندما انا اتكلم عن ال stars هنقول
+
+43
+00:03:17,050 --> 00:03:19,970
+انهم اتكلم عن ال stars بس في الواقع الحديث معاهم
+
+44
+00:03:19,970 --> 00:03:23,250
+يقولوا حول مين؟ حول اللي هو ال coronavirus خاصة في
+
+45
+00:03:23,250 --> 00:03:27,750
+ال characteristics العامة اللي منذ القرننصف أو
+
+46
+00:03:27,750 --> 00:03:32,270
+أكتر من نصف الأطفال أصيبوا بال coronavirus و اللي
+
+47
+00:03:32,270 --> 00:03:35,350
+أقصد فيها ال SARS تمام؟ ال coronavirus اللي بتسبب
+
+48
+00:03:35,350 --> 00:03:38,950
+الرشح اللي حكينا عنه ال outbreaks كنا بتحدث من
+
+49
+00:03:38,950 --> 00:03:44,260
+سنتين إلى تلت سنوات مش كل سنة زي مين كل سنةالـ
+
+50
+00:03:44,260 --> 00:03:47,080
+Respiratory syncytial و الـ Respiratory syncytial
+
+51
+00:03:47,080 --> 00:03:54,420
+virus و ذكرنا التفسير الهلمى لماذا هناك فترات
+
+52
+00:03:54,420 --> 00:04:00,120
+زمانية بين حدوث الأوبيا لنفس الميكروب مثلا هنشوف
+
+53
+00:04:00,120 --> 00:04:05,840
+كمان شوية ميكروب كل ستة لتسع سنوات بيعمل cycle من
+
+54
+00:04:05,840 --> 00:04:10,190
+out breaksالـ number of children أو ال number of
+
+55
+00:04:10,190 --> 00:04:13,530
+susceptible population لازم يكون enough for this
+
+56
+00:04:13,530 --> 00:04:18,500
+virus to produce outbreakفي ال .. في ال
+
+57
+00:04:18,500 --> 00:04:22,060
+respiratory syncytial virus كانت سنوية صح؟ هذا
+
+58
+00:04:22,060 --> 00:04:25,520
+معناه يحكي إن ال immunity completely incomplete
+
+59
+00:04:25,520 --> 00:04:30,620
+يعني هي أصلا مش تانمة وبالتالي كل سنة معرض إن
+
+60
+00:04:30,620 --> 00:04:35,200
+الناس ينصب هذا ال virus لكن لو ينصبوا بالربلة،
+
+61
+00:04:35,200 --> 00:04:39,910
+حيصير فيه انديواباة، القفار ممكن تموتواطفال كثيرة
+
+62
+00:04:39,910 --> 00:04:44,610
+هينجو ويكونوا مناعة السنة الجاية لو الفيروس اجا
+
+63
+00:04:44,610 --> 00:04:50,290
+نسبة الاعظم من الأطفال عندهم مناعة فبفكرة ال herd
+
+64
+00:04:50,290 --> 00:04:54,310
+immunity او ال community immunity لن يستطيع الربلة
+
+65
+00:04:54,310 --> 00:04:58,830
+ان يعمل وباء الا بعد مرور فترة من الزمن وظهور
+
+66
+00:04:58,830 --> 00:05:03,350
+اطفال جدد بكمية كافية لاحدات اللي هو الوباء ارجو
+
+67
+00:05:03,350 --> 00:05:07,030
+ان هذه النقطة تكون خلاص يعني اختمرت فيها أقولكم ان
+
+68
+00:05:07,030 --> 00:05:13,220
+شاء اللهال سارس originated in China في الصين في
+
+69
+00:05:13,220 --> 00:05:21,560
+نوفمبر 2002 وانتقل بشكل سريع إلى بلدان أخرىعندما
+
+70
+00:05:21,560 --> 00:05:26,920
+كنت بهذه الشرايح كان عادل حالات المصابة حوالي 9000
+
+71
+00:05:26,920 --> 00:05:33,280
+ومات منهم حوالي 800 بنسبة 13% mortality rate اعتقد
+
+72
+00:05:33,280 --> 00:05:37,640
+ان 13% mortality rate هذا رقم خطير ولا لا؟ يعني من
+
+73
+00:05:37,640 --> 00:05:41,540
+كل 100 شخص 13 واحد بدوا يموت هذا رقم بالفعل بيكون
+
+74
+00:05:41,540 --> 00:05:45,900
+صعب بالغايةالـ transmission and epidemiology
+
+75
+00:05:45,900 --> 00:05:50,720
+الانتقال أول ما صار انتقال في المستشفيات يعني
+
+76
+00:05:50,720 --> 00:05:55,220
+المريض اللي إجا مصاب نقل لمين؟ لل health care
+
+77
+00:05:55,220 --> 00:06:01,360
+workers واعتقدوا أنه حتى أن الناس المصابين في منهم
+
+78
+00:06:01,360 --> 00:06:05,110
+مجموعة بسموهم super spreaderإيش يعني super
+
+79
+00:06:05,110 --> 00:06:10,790
+spreader؟ يعني وجود الفيروس في هذا الإنسان بيجعل
+
+80
+00:06:10,790 --> 00:06:14,630
+هذا الإنسان قادر على نقله إلى عدد كبير جدا من مين؟
+
+81
+00:06:14,630 --> 00:06:18,730
+من الناس الآخرين، فبيسموهم super spreader لكن هذا
+
+82
+00:06:18,730 --> 00:06:23,930
+المصطلح yet to be confirmedلحد الآن لم يثبت علميا
+
+83
+00:06:23,930 --> 00:06:27,490
+انه فيه انحاء اسمها super spreader لكن كان فيه
+
+84
+00:06:27,490 --> 00:06:31,930
+prediction او تنبؤات انه ممكن يكون super spreader
+
+85
+00:06:31,930 --> 00:06:35,570
+التنبؤات هي بناء على ايه؟ بناء على ما رأوهم
+
+86
+00:06:35,570 --> 00:06:39,710
+الملاحظات وانتشار سريع في بعض الأماكن اللي زي
+
+87
+00:06:39,710 --> 00:06:46,370
+المستشفيات طب كيف اتخلصنا من جثة المستشفيات انه
+
+88
+00:06:46,370 --> 00:06:49,360
+يسيب انتقال؟ فيه انحاء اسم يا بنات؟Infection
+
+89
+00:06:49,360 --> 00:06:54,140
+Control Measures، إجراءات اللي هو منع العدوى، الآن
+
+90
+00:06:54,140 --> 00:06:58,280
+إجراءات منع العدوى مصطلحة عامة لها، مصطلحة عامة،
+
+91
+00:06:58,280 --> 00:07:02,560
+العدوى قد تكون عبر الجلد، قد تكون عبر الإبر، عبر
+
+92
+00:07:02,560 --> 00:07:07,020
+الشاربز، طب لما تكون عبر ال respiratory، فيه إلها
+
+93
+00:07:07,020 --> 00:07:11,030
+إجراءات خاصةفاحنا لو كان في مرض بينتقل عن طريق
+
+94
+00:07:11,030 --> 00:07:15,470
+الجهاز التنفسي، بنقول يلا ابدأوا تطبقوا إجراءات
+
+95
+00:07:15,470 --> 00:07:18,950
+منع العدوى المتعلقة بمين بأمراض الجهاز التنفسي،
+
+96
+00:07:18,950 --> 00:07:23,450
+وفي الحقيقة أنه جابت نتيجة وقللت نسب الإصابة في
+
+97
+00:07:23,450 --> 00:07:26,070
+العاملين في القطاع الصحي اللي بتعاملوا مع مرضى
+
+98
+00:07:26,070 --> 00:07:32,540
+الصارسالان في عندي نقطة تانية انه في animal
+
+99
+00:07:32,540 --> 00:07:36,220
+reservoir animal reservoir ايش يعني animal
+
+100
+00:07:36,220 --> 00:07:40,300
+reservoir؟ يعني في مخازن حيوانية لل coronavirus
+
+101
+00:07:40,300 --> 00:07:45,060
+ويعتقد انه يلها دور كبير في انتقالها لمين؟ للإنسان
+
+102
+00:07:45,060 --> 00:07:50,340
+في حيوانين اتنين رئيسي الخفاش الذي يشبه حدوة
+
+103
+00:07:50,340 --> 00:07:55,070
+الحصار بسموه horseأو shoe horse مش عارف هورس شو
+
+104
+00:07:55,070 --> 00:07:59,470
+هورس شو اللي هو حدوث الحصار بقت هذا ك reservoir
+
+105
+00:07:59,470 --> 00:08:04,330
+natural reservoir وفيه حاسمة civet cat قطة ال
+
+106
+00:08:04,330 --> 00:08:09,410
+civet طبعا هذه القطة تؤكل من قبل الصينين يعني
+
+107
+00:08:09,410 --> 00:08:13,250
+بيبيعوها في الأسواق و بيأكلوها الصينين فبيعتقدوا
+
+108
+00:08:13,250 --> 00:08:16,430
+أنها intermediate host intermediate host يعني هي
+
+109
+00:08:16,430 --> 00:08:22,200
+اللي بتنقلفمعظم الحالات اللي أصيبت originally مش
+
+110
+00:08:22,200 --> 00:08:25,820
+اللي هم موردين من الأطباء كانت أصيبت من من من
+
+111
+00:08:25,820 --> 00:08:30,000
+تناولهم أو تعابلهم مع من مع ال cats مش مع الخفافيش
+
+112
+00:08:30,000 --> 00:08:35,220
+وانما مع هذا النوع من القطط ال coronavirus
+
+113
+00:08:35,220 --> 00:08:39,140
+infection is typically limited to mycosal cells of
+
+114
+00:08:39,140 --> 00:08:43,240
+the respiratory tract يعني بتخترقش إلى أماكن أخرى
+
+115
+00:08:43,240 --> 00:08:48,890
+فقط بتكون في الmycosal cellsحوالي خمسين بالمائة من
+
+116
+00:08:48,890 --> 00:08:53,350
+نسب الإصابة أو من الإصابة بتكون asymptomatic وكلمة
+
+117
+00:08:53,350 --> 00:08:57,510
+asymptomatic يعني ايه؟ يعني مافيش أعراض وانا وانا
+
+118
+00:08:57,510 --> 00:09:03,910
+سؤال هل لهؤلاء ال asymptomatic patients دور في نقل
+
+119
+00:09:03,910 --> 00:09:09,270
+المرض ولا مالهمش دور؟انت على طول قلت اه يعني و
+
+120
+00:09:09,270 --> 00:09:11,970
+احنا قاعدين بقولكوا ان العالم بيقول it is unclear
+
+121
+00:09:11,970 --> 00:09:15,310
+يعني ليس من الواضح و انتوا على طول قفتتوا انه ايه
+
+122
+00:09:15,310 --> 00:09:18,590
+مع ان انا حذرتكم المحاضرة الماضية و قلتلكوا يا
+
+123
+00:09:18,590 --> 00:09:23,970
+جماعة لغة ال science دايما مشككة مشككة و ليست
+
+124
+00:09:23,970 --> 00:09:28,150
+قاطعة بس انتوا طبعا تحبوا تقطعوا الشك باليقين
+
+125
+00:09:32,480 --> 00:09:35,320
+يعني حتى لما بنعمل في فيسبوك يا like يا dislike،
+
+126
+00:09:35,320 --> 00:09:40,180
+مافيش حلول وسط عنها، immunity following infection
+
+127
+00:09:40,180 --> 00:09:45,360
+appears to be brief، brief مانعها قصيرة، يعني
+
+128
+00:09:45,360 --> 00:09:48,480
+المناعة اللي بنحصل عليها بعد العدوى بتكون قصيرة،
+
+129
+00:09:48,480 --> 00:09:52,600
+لذلك multiple infection can occur، يعني بنقدر نصاب
+
+130
+00:09:52,600 --> 00:09:55,660
+بال coronavirus مرارا وتكرار
+
+131
+00:09:59,210 --> 00:10:07,090
+السعر السيئ بالوفيات فيه غالبا الغرق،
+
+132
+00:10:07,090 --> 00:10:12,990
+ماهو رأيكم؟ الإنسان كيف بيغرق؟ بانملع عن الأكسجين،
+
+133
+00:10:12,990 --> 00:10:17,030
+مظبوط؟طبعا لو .. لو .. لو مانعب ال oxygen بال ..
+
+134
+00:10:17,030 --> 00:10:21,230
+بالخنق، لكن هذا لا يخنق، وإنما السوائل will build
+
+135
+00:10:21,230 --> 00:10:25,050
+up in the lungs، فبالتالي هو مانخنقش، هو غرق
+
+136
+00:10:25,050 --> 00:10:28,210
+بالفعل، غرق في اللي هو السوائل اللي موجودة في ال
+
+137
+00:10:28,210 --> 00:10:31,970
+lungs تبعته، وبالتالي صار عنده hypoxia أو نقص في
+
+138
+00:10:31,970 --> 00:10:36,840
+ال oxygen وبالتالي ممكن يموتالـ Clinical finding
+
+139
+00:10:36,840 --> 00:10:39,680
+هو الـ common cold caused by Corona virus is
+
+140
+00:10:39,680 --> 00:10:42,200
+characterized by Choriza Choriza اللي هي الـ runny
+
+141
+00:10:42,200 --> 00:10:46,940
+nose زي ما حكينا، scratchy sore throat، بيكون
+
+142
+00:10:46,940 --> 00:10:51,340
+المريض يلخطر يحقق الحلق طبعه من جوا، ليش؟ لأنه في
+
+143
+00:10:51,340 --> 00:10:54,690
+شعور بالنمنة تماما بالحكةفي الـ sore throat وعلى
+
+144
+00:10:54,690 --> 00:11:00,190
+فكرة هذا common بين الناس ودلأسف بياخدوا
+
+145
+00:11:00,190 --> 00:11:03,990
+antibiotic برضه لعلاج هذا النوع من ال sore throat
+
+146
+00:11:03,990 --> 00:11:09,330
+وهو لا يحتاج وغالبا هتشوفوا ان ال coronavirus are
+
+147
+00:11:09,330 --> 00:11:13,570
+self-limited ومافيش اي يعني consequences او
+
+148
+00:11:13,570 --> 00:11:16,590
+complications لل disease غالبا self-limited بتروح
+
+149
+00:11:16,590 --> 00:11:25,890
+لحالة بدون اي اعراض جانبيالصحيحة تبقى مجموعة
+
+150
+00:11:25,890 --> 00:11:31,470
+أيام وليس لديها
+
+151
+00:11:31,470 --> 00:11:36,830
+أثار طويل على المدى البعيد كورونا فايروس أيضا يسبب
+
+152
+00:11:36,830 --> 00:11:42,230
+برونكايتس صارتز هو نيومونيا عادية وذكرنا عنه قبل
+
+153
+00:11:42,230 --> 00:11:48,090
+قليل ومخصص من حرارة 38 درجة سنتيجريلNon-productive
+
+154
+00:11:48,090 --> 00:11:51,950
+cough مش هي non-productive cough يعني كحة ما بيطلع
+
+155
+00:11:51,950 --> 00:11:55,470
+فيها المريض Sputum تمام؟ بينما ال productive cough
+
+156
+00:11:55,470 --> 00:11:59,870
+بتكون كحة جافة يعني زي dry cough، dyspnea اختناق
+
+157
+00:11:59,870 --> 00:12:03,690
+and هيبوكسيا أو قلنا هيبوكسيا نتج عن ال
+
+158
+00:12:03,690 --> 00:12:06,790
+accumulation لمين؟ لل fluid في ال lungs
+
+159
+00:12:09,510 --> 00:12:13,490
+اللي أنا ما زلت في الفقرة التالية أتحدث عن مين عن
+
+160
+00:12:13,490 --> 00:12:17,710
+ال SARS، chills, rigors, malaise and headache
+
+161
+00:12:17,710 --> 00:12:23,370
+commonly occur، but sore throat and rhinorrhea are
+
+162
+00:12:23,370 --> 00:12:27,170
+uncommon، يعني إن يكون فيه runny nose وإن يكون فيه
+
+163
+00:12:27,170 --> 00:12:30,070
+التهيبات في الحلق، بتكونش common في مين؟ في ال
+
+164
+00:12:30,070 --> 00:12:34,490
+SARS، ال SARS أكتر شكل النيومونيا، بينما ال other
+
+165
+00:12:34,490 --> 00:12:37,690
+coronavirus بتكون upper respiratory tract
+
+166
+00:12:37,690 --> 00:12:41,040
+infectionفي الـ SARS أيضًا بيكون في انديليوكوبينيا
+
+167
+00:12:41,040 --> 00:12:43,560
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+168
+00:12:43,560 --> 00:12:43,620
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+169
+00:12:43,620 --> 00:12:44,640
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+170
+00:12:44,640 --> 00:12:44,760
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+171
+00:12:44,760 --> 00:12:44,800
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+172
+00:12:44,800 --> 00:12:44,860
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+173
+00:12:44,860 --> 00:12:45,020
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+174
+00:12:45,020 --> 00:12:45,480
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+175
+00:12:45,480 --> 00:12:49,380
+و .. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+176
+00:12:49,380 --> 00:12:53,260
+و .. و
+
+177
+00:12:53,260 --> 00:12:55,980
+.. و .. و .. و .. و .. و .. و .. و .. و .. و ..
+
+178
+00:13:04,260 --> 00:13:07,840
+وقت محدد، تلت أيام، أربع أيام، خمس أيام، ماعنديش
+
+179
+00:13:07,840 --> 00:13:14,940
+بنقول ده من ال range بس الجرعة
+
+180
+00:13:14,940 --> 00:13:18,740
+اللي هي ال dos بالإضافة إلى مين؟ إلى اللي هو ال
+
+181
+00:13:18,740 --> 00:13:22,660
+immunity وهل أصلا في previous contact مع ال virus
+
+182
+00:13:22,660 --> 00:13:25,340
+ولا مافيش previous contact مع ال virus؟ هذا فيه
+
+183
+00:13:25,340 --> 00:13:28,780
+كثير من الأحيان، لكن في أحيان أخرى الأمر مرتبط
+
+184
+00:13:28,780 --> 00:13:33,560
+ممكن يكون بعامل أخرى، مثلاالـ rabies اللي حدثه
+
+185
+00:13:33,560 --> 00:13:40,400
+لاحقا في هذا الفصل أيضا ال incubation period وظهور
+
+186
+00:13:40,400 --> 00:13:46,640
+الأعراض الرئيسية مرتبط ببعد العضة بتاعة الكلب أو
+
+187
+00:13:46,640 --> 00:13:51,200
+الخفاش أو whatsoever اه او النمر تخيلوا نمر عشان
+
+188
+00:13:51,200 --> 00:13:52,280
+يعمله rabies
+
+189
+00:13:54,910 --> 00:13:59,230
+بعد عن الجهاز العصب المركزي لما بتكون جريبة بيكون
+
+190
+00:13:59,230 --> 00:14:03,310
+فيه فترة incubation قصيرة يعني لو كانت العضة في
+
+191
+00:14:03,310 --> 00:14:06,390
+مكان في الرقب أو في الكتف أو في مكان في الرأس
+
+192
+00:14:06,390 --> 00:14:11,210
+بتكون بسرعة تحدث اللي هو الأعراض تدهور بسرعة لكن
+
+193
+00:14:11,210 --> 00:14:16,050
+لو كانت بعيدة مثلا في الساق هذا بيعطي فترة أطول لل
+
+194
+00:14:16,050 --> 00:14:18,470
+incubation period إذا ال incubation period في
+
+195
+00:14:18,470 --> 00:14:21,750
+مجموعة عوام اللي قد تؤثر عليها نوع ال microbe
+
+196
+00:14:22,360 --> 00:14:25,260
+المايكروب بتاعي فيه اختلافات فيه شي 7 على 10 ايام
+
+197
+00:14:25,260 --> 00:14:31,460
+فيه 10 على 24 فيه يومين تمام زي ال influenza زي
+
+198
+00:14:31,460 --> 00:14:35,580
+الرشح يعني ال incubation period معتمدة على واحد
+
+199
+00:14:35,580 --> 00:14:39,440
+نوع المايكروب اتنين الجرعة تلاتة المناعة ال site
+
+200
+00:14:39,440 --> 00:14:44,060
+of entry مكان دخول اللي هو ال virus او ال مايكروب
+
+201
+00:14:47,130 --> 00:14:49,710
+الـ diagnosis of the common cold is made clinical،
+
+202
+00:14:49,710 --> 00:14:52,410
+و للأسف لما أستطيع بالـ clinical diagnosis أنني
+
+203
+00:14:52,410 --> 00:14:54,990
+أتميز أن هذا رينوفيروس ولا كورونافيروس ولا
+
+204
+00:14:54,990 --> 00:14:58,930
+أدينوفيروس ولا رسبراتوريس انسيتيل ولا بعرع
+
+205
+00:14:58,930 --> 00:15:01,650
+انفلوانذافارات، مقدرش أنني أتميز بينهم، ولكن بنقول
+
+206
+00:15:01,650 --> 00:15:07,370
+common coldلحظوا ال common cold كلهم self-limited
+
+207
+00:15:07,370 --> 00:15:10,910
+ولا واحد من اللي احنا درسناهم في بيعمل ايه له
+
+208
+00:15:10,910 --> 00:15:14,410
+complications وبتالي بس لو احنا جولنا common cold
+
+209
+00:15:14,410 --> 00:15:19,110
+وشخصنا صح انتهى الموضوع سواء راحة انتهى او انتهت
+
+210
+00:15:19,110 --> 00:15:23,810
+الجثة في هذا الموضوع لكن اذا SARS لا نكتفي بال
+
+211
+00:15:23,810 --> 00:15:26,930
+clinical diagnosis لازم يكون فيه انها antibody
+
+212
+00:15:26,930 --> 00:15:33,830
+based test او PCR based testبالتعليم والتحقيق، لا
+
+213
+00:15:33,830 --> 00:15:38,210
+يوجد
+
+214
+00:15:38,210 --> 00:15:44,950
+علاج أو تطييب لهذا الفيروس، لكن في محاولة أجريت
+
+215
+00:15:44,950 --> 00:15:48,210
+باستخدام الريبافرين، وريبافرين هيثار مر معانا كتير
+
+216
+00:15:48,210 --> 00:15:53,090
+في هذا الفصل أو في هذا ال chapter يعني أقصد،
+
+217
+00:15:53,090 --> 00:15:56,590
+الريبافرين بالإضافة إلى الستيرويتس كانوا يحاولوا
+
+218
+00:15:56,590 --> 00:16:03,290
+في التعليم للحياةLife-threatening cases يعني حالات
+
+219
+00:16:03,290 --> 00:16:09,170
+مهددة للحياة و التالي المحاولة بأي شيء قد يعني
+
+220
+00:16:09,170 --> 00:16:15,210
+تساعد but their efficacy is uncertain للجماعة اللي
+
+221
+00:16:15,210 --> 00:16:20,510
+على طول بيفتو ان اه او لا احنا كل مرة بنقولكوا على
+
+222
+00:16:20,510 --> 00:16:25,190
+الرغم من المحاولات انه مش جادرين نحدد هل بالفعل ال
+
+223
+00:16:25,190 --> 00:16:29,180
+effectiveness تبعها عالي ولا منخفضهل في المستقبل
+
+224
+00:16:29,180 --> 00:16:33,240
+نعتمد هذا النوع من الهلاجة ولا لأ؟ ليش ال
+
+225
+00:16:33,240 --> 00:16:37,460
+uncertainty موجودة؟ هل احنا بنحب انه دائما نكون
+
+226
+00:16:37,460 --> 00:16:43,520
+مشككين؟ همنحبش نكون مشككين، لكن عدد المرضى اللي
+
+227
+00:16:43,520 --> 00:16:46,780
+اتعاملنا معاهم على سبيل المثال بيكون قليلالـ
+
+228
+00:16:46,780 --> 00:16:50,760
+outcome اللي طلعت ال percentage اللي طلعت اشي منهم
+
+229
+00:16:50,760 --> 00:16:54,220
+اكترين بالمية okay اكترين و تلاتين بالمية مش okay
+
+230
+00:16:54,220 --> 00:16:58,120
+يعني بمعنى بمعنى اخر انه مش قادر احصل على نتيجة
+
+231
+00:16:58,120 --> 00:17:02,140
+conclusive حاسمة تقول ان والله هذا treatment is
+
+232
+00:17:02,140 --> 00:17:05,990
+effectiveوبيكونوا يتذكروا أن أي استيرويد تُعطى
+
+233
+00:17:05,990 --> 00:17:08,950
+للبنادمين لازم تُعطى بحدها، لأن احنا أصلا مش
+
+234
+00:17:08,950 --> 00:17:13,090
+فاهمين بالضبط كيف الاستيرويد تشتغل، بتعمل عاصفة في
+
+235
+00:17:13,090 --> 00:17:20,230
+الجسم، وبيستفيد الجسم في بعض الأحيانلكن دائما و
+
+236
+00:17:20,230 --> 00:17:25,210
+أبدا هناك مضار من استخدام الاستيرايد تمام؟ فبرضه
+
+237
+00:17:25,210 --> 00:17:30,130
+مش لازم نستخدم الاستيرايد إلا بحضر و under control
+
+238
+00:17:30,130 --> 00:17:34,350
+لازم يكون الأطباء موجودين و يشوفوا إيش ممكن يصير
+
+239
+00:17:34,350 --> 00:17:39,770
+فيه مضاعفة الفيروس التالي في السلسلة خلصنا كورونا
+
+240
+00:17:39,770 --> 00:17:43,270
+فيروس الآن نتكلم عالميا عن روبيلا لحظة روبيلا
+
+241
+00:17:43,270 --> 00:17:48,220
+ارتبط اسمه بال missiles و بالممصص صح؟الميسلز
+
+242
+00:17:48,220 --> 00:17:54,540
+والمامس تبين لمين؟ بالبارا مايوكسي هذا مالوش علاقة
+
+243
+00:17:54,540 --> 00:17:58,080
+.. هذا مالوش علاقة فيهم على الرغم من ان هم التلات
+
+244
+00:17:58,080 --> 00:18:03,920
+مالهم في نفس ال vaccine ولاحظوا disease missiles و
+
+245
+00:18:03,920 --> 00:18:08,420
+german missiles وكلاهما .. كلاهما بيحدثوا تقريبا
+
+246
+00:18:08,420 --> 00:18:13,400
+نفس المرض لكن بينتموا إلى عائلات وتركيبات مختلفة
+
+247
+00:18:13,400 --> 00:18:18,580
+البارا مايوكسي فيروس ابناتnegative sins هذا
+
+248
+00:18:18,580 --> 00:18:23,020
+positive sins نعم تواجه فيروس بيختلف تماما عن ال
+
+249
+00:18:23,020 --> 00:18:27,480
+Paramyoxic virus هادلاك كانوا helical هادي
+
+250
+00:18:27,480 --> 00:18:32,580
+eicosahedral إذا في اختلاف بينهم على الرغم من أنهم
+
+251
+00:18:32,580 --> 00:18:37,610
+بيسببوا تقريبا أمراض شبيهة بعضها البعضالفيروس يسبب
+
+252
+00:18:37,610 --> 00:18:41,470
+فيه اتجارات اتجارات اتجارات اتجارات اتجارات
+
+253
+00:18:41,470 --> 00:18:42,990
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+254
+00:18:42,990 --> 00:18:44,630
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+255
+00:18:44,630 --> 00:18:48,450
+اتجارات اتجارات اتجارات اتجارات
+
+256
+00:18:48,450 --> 00:18:50,250
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+257
+00:18:50,250 --> 00:18:50,310
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+258
+00:18:50,310 --> 00:18:50,710
+اتجارات اتجارات اتجارات اتجارات اتجارات اتجارات
+
+259
+00:18:50,710 --> 00:18:55,310
+اتجارات اتجارات اتجارات
+
+260
+00:18:55,310 --> 00:18:56,190
+اتجارات
+
+261
+00:19:00,790 --> 00:19:04,250
+Cytomegalovirus الان اذا بتذكروا الجملة ايش بتقول
+
+262
+00:19:04,250 --> 00:19:08,830
+ان ال CMV في اللي درسناها بتقول ان ال CMV is one
+
+263
+00:19:08,830 --> 00:19:12,790
+of the leading causes of congenital abnormality in
+
+264
+00:19:12,790 --> 00:19:15,710
+the united states فمهما بيعمل congenital
+
+265
+00:19:15,710 --> 00:19:20,530
+abnormality تذكروا ان ال CMV مايوجدوش vaccine هدا
+
+266
+00:19:20,530 --> 00:19:23,530
+اله vaccine ال vaccine عمل reduction
+
+267
+00:19:26,140 --> 00:19:30,420
+للحالات الربلة بشكل عام وبالتالي عمل reduction
+
+268
+00:19:30,420 --> 00:19:34,020
+لحالات ايضا ال congenital rebel اذا احنا خفضنا
+
+269
+00:19:34,020 --> 00:19:37,080
+الربلة العادية وبالتالي خفضنا ايضا مين اللي هو ال
+
+270
+00:19:37,080 --> 00:19:42,120
+congenital abnormal ال
+
+271
+00:19:42,120 --> 00:19:45,100
+characteristics بتاعة الفيروس هنا toga virus قلنا
+
+272
+00:19:45,100 --> 00:19:51,620
+هو مش بعلم يكسي ولا كورونا هو toga virusone piece
+
+273
+00:19:51,620 --> 00:19:56,100
+of a single-stranded RNA eicosahedral nucleocapsid
+
+274
+00:19:56,100 --> 00:19:58,660
+and a lipoprotein envelope يعني برضه still
+
+275
+00:19:58,660 --> 00:20:01,980
+envelope لإن احنا أصلا عنوانها ماتنسوش RNA
+
+276
+00:20:01,980 --> 00:20:08,340
+enveloped virus على النقيض ال paramyoxiv viruses
+
+277
+00:20:08,340 --> 00:20:12,280
+زي الميسلز والممس اللي هم اخوتوه في ال vaccine مش
+
+278
+00:20:12,280 --> 00:20:17,110
+في الرضاعة اخوتوه في ال vaccineit has a positive
+
+279
+00:20:17,110 --> 00:20:20,510
+-stranded RNA، يعني مع الحاجة اللوتانية الشمالهم،
+
+280
+00:20:20,510 --> 00:20:24,510
+negative-stranded RNA، and therefore it has no
+
+281
+00:20:24,510 --> 00:20:29,110
+virion polymerase، بينما الميسلز والمامس كانوا
+
+282
+00:20:29,110 --> 00:20:32,630
+بيحتاجوا RNA dependent، RNA polymerase يكون معاهم
+
+283
+00:20:32,630 --> 00:20:37,360
+في ال virus particleالـ spikes بتحتوي على
+
+284
+00:20:37,360 --> 00:20:42,680
+hemagglutinin، single antigenic type، سر نجاحنا في
+
+285
+00:20:42,680 --> 00:20:46,960
+الفاكسين، ان one single serotype وان ال human are
+
+286
+00:20:46,960 --> 00:20:52,480
+the only natural host for this virus، و ال
+
+287
+00:20:52,480 --> 00:20:56,580
+antibody directed against hemagglutinin
+
+288
+00:20:56,580 --> 00:21:00,560
+neutralizes infectivity، و أنا بالدجاج عندها دي
+
+289
+00:21:00,560 --> 00:21:09,700
+نقطة نظامneutralizes infectivity ما بتعني لكم ان
+
+290
+00:21:09,700 --> 00:21:14,880
+الفيروس هي عنده hemagglutinin اذا الانتيبادرتبط
+
+291
+00:21:14,880 --> 00:21:20,260
+فيه منعه انه يعمل infection للخلايا ممتاز قليلة
+
+292
+00:21:20,260 --> 00:21:25,860
+عمره جيد في كل مرة وان في مرة ماكانش جيد
+
+293
+00:21:29,790 --> 00:21:33,770
+في ال respiratory syncytial virus فاكرين؟ المرض
+
+294
+00:21:33,770 --> 00:21:37,430
+أصلا كان ناتج عن مين؟ عن ارتباط على الرغم من أنه
+
+295
+00:21:37,430 --> 00:21:41,650
+بالفعل ال antibody عمل neutralizers لل infectivity
+
+296
+00:21:41,650 --> 00:21:45,930
+of the virus لكن ال disease كان ناتج عن الارتباط
+
+297
+00:21:45,930 --> 00:21:48,690
+هذا لأنه عمل activation لل complement عمل
+
+298
+00:21:48,690 --> 00:21:52,890
+destruction لل lungs cells جمعت ال immune system
+
+299
+00:21:52,890 --> 00:21:57,370
+برضه عمل destruction إضافي لل lungsإذا كلمة
+
+300
+00:21:57,370 --> 00:22:02,930
+neutralizes infectivity معناها واحد بأن الفيروس لم
+
+301
+00:22:02,930 --> 00:22:09,750
+يعد قادرا على إصابة الخلايا ومن ثم تكاثر لكن هذا
+
+302
+00:22:09,750 --> 00:22:14,110
+لا يعني أنه بالضرورة أنه .. أنه كويس، عايشوفنا مرة
+
+303
+00:22:14,110 --> 00:22:18,030
+كويس في هذا الحالة تمام؟ ومرة مش كويس في حالة مين؟
+
+304
+00:22:18,030 --> 00:22:19,970
+ال respiratory syncytial virus
+
+305
+00:22:24,190 --> 00:22:27,710
+The virus is transmitted via respiratory droplets
+
+306
+00:22:27,710 --> 00:22:31,550
+كل يوم جاعدين نتأكد .. نتأكد و بنأكد الحقيقة اللي
+
+307
+00:22:31,550 --> 00:22:36,710
+ذكرناها ان ال enveloped viruses تنار غالبا فيروسات
+
+308
+00:22:36,710 --> 00:22:40,130
+حساسة و بدها close contact و غالبا ال respiratory
+
+309
+00:22:40,130 --> 00:22:44,250
+او sexual contact هو ال mean of ال transmission او
+
+310
+00:22:44,250 --> 00:22:45,830
+ال direct transmission
+
+311
+00:22:47,950 --> 00:22:51,870
+إذن في طريقتين للانتقال إما Transplacental من الأم
+
+312
+00:22:51,870 --> 00:22:55,690
+إلى الجنين أو عبر الrespiratory droplets. The
+
+313
+00:22:55,690 --> 00:22:59,810
+disease is worldwide. In areas where the vaccine
+
+314
+00:22:59,810 --> 00:23:03,550
+is not used, epidemics occur every six to nine
+
+315
+00:23:03,550 --> 00:23:06,610
+years. المثال اللي ذكرناه قبل قليل، قلنا لكم إنه
+
+316
+00:23:06,610 --> 00:23:11,010
+كل ست إلى تسع سنوات بيحدث اللي هو التفشي أو
+
+317
+00:23:11,010 --> 00:23:16,780
+الوباء. في ال 2005 ال CDCواللي مابيعوش ال CDC لازم
+
+318
+00:23:16,780 --> 00:23:20,120
+يعرفه هو ال Center for Disease Control في الولايات
+
+319
+00:23:20,120 --> 00:23:22,960
+المتحدة، إله أفرا كثيرة، لكن الفرع الرئيسي فيه
+
+320
+00:23:22,960 --> 00:23:27,640
+Atlanta في الولايات المتحدة، هذا المركز يُعتبر
+
+321
+00:23:27,640 --> 00:23:31,280
+المركز الأول في العالم في مكافحة الأمراض الماضية
+
+322
+00:23:31,830 --> 00:23:35,990
+وين في مرض غريب في العالم بيبعته أفراد من ال CDC
+
+323
+00:23:35,990 --> 00:23:38,810
+عندهم مختبرات متطورة عندهم Epidemiologist عندهم
+
+324
+00:23:38,810 --> 00:23:44,210
+حواسيب عندهم برامج عندهم fund محترم جدا لعملية
+
+325
+00:23:44,210 --> 00:23:47,050
+التعرف على الأمراض المواضية يعني هم ال
+
+326
+00:23:47,050 --> 00:23:51,390
+microbusters هم اللي اللي بيلاحقوا الميكروبات في
+
+327
+00:23:51,390 --> 00:23:55,650
+العالم وخاصة الميكروبات الجديدة أو اللي تظهر حديثة
+
+328
+00:23:56,850 --> 00:23:59,910
+موقعهم جانى بالمعلومات للي بيحب يعني يزيد من أي
+
+329
+00:23:59,910 --> 00:24:03,950
+ميكروب من الميكروبات يعرف عنه أي معلومات بيدخل على
+
+330
+00:24:03,950 --> 00:24:05,930
+ال CDC.gov
+
+331
+00:24:12,260 --> 00:24:16,080
+أنا شخصيا بستفيد منه خاصة في طائع المحاضرات لما
+
+332
+00:24:16,080 --> 00:24:20,240
+بيكون بدي update بدي أرقام جديدة و بدي أعمل محاضرة
+
+333
+00:24:20,240 --> 00:24:24,040
+لناس يعني متخصصين في المجال المعين و بدي أعطيهم
+
+334
+00:24:24,040 --> 00:24:27,860
+أرقام حديثة باخد من ال CDC و من حاسبها ProMed يعني
+
+335
+00:24:27,860 --> 00:24:31,160
+و ال WHO ده هو التلات مصادر الرئيسية اللي باخد
+
+336
+00:24:31,160 --> 00:24:36,600
+منهم معلومات عن الأمراض المؤدمةElimination قررت
+
+337
+00:24:36,600 --> 00:24:42,780
+هذه المؤسسة أن الولايات المتحدة خالية من الروبيلا
+
+338
+00:24:42,780 --> 00:24:49,480
+في 2005 وعزوا هذا الخلو من الروبيلا إلى الاستخدام
+
+339
+00:24:49,480 --> 00:24:53,820
+الواسع لـ Vaccination ProgramAs a result,
+
+340
+00:24:54,560 --> 00:24:58,180
+cytomegalovirus خلصنا من الربلة اللى بتعمل
+
+341
+00:24:58,180 --> 00:25:01,320
+congenital abnormality وبالتالي مين أنصار الأول
+
+342
+00:25:01,320 --> 00:25:04,840
+صار ال cytomegalovirus هو السبب الأول فيه اللى هو
+
+343
+00:25:04,840 --> 00:25:09,320
+ال congenital abnormality برضه بنجر فعندها نقطة
+
+344
+00:25:09,320 --> 00:25:14,260
+صغيرة ونوضح بعض الأمور تسمع بمصطلح changing
+
+345
+00:25:14,260 --> 00:25:19,480
+epidemiology أو تغير الوبائيات تغير الوبائياتأنا
+
+346
+00:25:19,480 --> 00:25:24,400
+بدأ أقولكوا نماذج و هذا من النماذج أو نموذج من
+
+347
+00:25:24,400 --> 00:25:29,900
+النماذج الـ streptococcus pneumonia كانت one of
+
+348
+00:25:29,900 --> 00:25:33,240
+the leading one of the leading causes of
+
+349
+00:25:33,240 --> 00:25:38,500
+meningitis in young children واحد من أهم مسببات
+
+350
+00:25:38,500 --> 00:25:42,120
+التهاب الصحي في العالم فهذه ال pneumonia اشتبعتها
+
+351
+00:25:42,120 --> 00:25:46,340
+worldwide تمام؟ راح العالم عمل vaccine لـ
+
+352
+00:25:46,340 --> 00:25:49,230
+streptococcus pneumoniaلما عملنا فاكسينة لـ
+
+353
+00:25:49,230 --> 00:25:53,170
+Stratococcus pneumonia قلت نسب الإصابة بالـ Otitis
+
+354
+00:25:53,170 --> 00:25:57,050
+Media و بالـ Eye Infection وبالتالي قلت كمان نسب
+
+355
+00:25:57,050 --> 00:26:01,270
+الإصابة بالاتهاب الصحية الآن صار مين الأول؟
+
+356
+00:26:01,270 --> 00:26:04,630
+إشريشيا كولاي يبقى ت .. ت .. لما أنا عملت
+
+357
+00:26:04,630 --> 00:26:09,050
+intervention تغيرت الوبائي اللي صالح مين؟ بصالح؟
+
+358
+00:26:09,050 --> 00:26:10,730
+مع أنه كانت .. ما كانت بالأول اللي هي الـ
+
+359
+00:26:10,730 --> 00:26:13,790
+Stratococcus pneumonia الآن صارت مثلا إشريشيا
+
+360
+00:26:13,790 --> 00:26:19,760
+كولاي يبقىما بنقدرش احنا نبقى نثبتنا المعلومة
+
+361
+00:26:19,760 --> 00:26:24,660
+ونقول ان المسبب الاول هو X اذا صار فيه
+
+362
+00:26:24,660 --> 00:26:29,120
+intervention او صار فيه تغير في الوبائية يعني مثلا
+
+363
+00:26:29,120 --> 00:26:33,180
+انا دايما بقول الجملة دي وانتم اسموتها مرارا ان
+
+364
+00:26:33,180 --> 00:26:37,540
+الأمراض المعدية كانت هي السبب في قتل 53% من سكان
+
+365
+00:26:37,540 --> 00:26:40,440
+العالم او مش كل العالم عفوا من نسبة الوفيات في
+
+366
+00:26:40,440 --> 00:26:44,350
+العالمتلاتة و خمسين بالمية اليوم حصدها جداش تلاتة
+
+367
+00:26:44,350 --> 00:26:47,690
+بالمية هتتغير في الوبائي ولا مش تتغير في الوبائية
+
+368
+00:26:47,690 --> 00:26:51,890
+ملعب السكر كان يصيب فقط من أعمارها من فوق الستين
+
+369
+00:26:51,890 --> 00:26:54,110
+اللي كان بيصيب الشباب اللي عمره عمري و عشرين سنة
+
+370
+00:26:54,110 --> 00:26:56,650
+من النوع التاني لأ لأ من .. هدا كان النوع الأول
+
+371
+00:26:56,650 --> 00:26:59,010
+ممكن اللي هو النوع التاني عشرين و تلاتين و اربعين
+
+372
+00:26:59,010 --> 00:27:01,990
+إذن الوبائي اللي بيبقى ملها تتغير فانا أرجو من
+
+373
+00:27:01,990 --> 00:27:06,590
+حضراتكم تفهم هذا المصطلح ان changing epidemiology
+
+374
+00:27:06,590 --> 00:27:11,630
+او epidemics تمام هذا مرهون بسلوك البشر و بال
+
+375
+00:27:11,630 --> 00:27:14,510
+intervention في ال pollution في ال global warming
+
+376
+00:27:14,510 --> 00:27:19,310
+في شرائط كتيرة في اكتشاف drugs في تعلم حقائق جديدة
+
+377
+00:27:19,310 --> 00:27:23,790
+يعني انا جدناكوا غصل الإيدان انقذ حياة الملايين من
+
+378
+00:27:23,790 --> 00:27:26,850
+الأمهات في المستشفيات في عمليات الولادة لما
+
+379
+00:27:26,850 --> 00:27:30,890
+اتعلموا نصف الإيدان فقط فدائما بدنا نفهم ان
+
+380
+00:27:30,890 --> 00:27:34,690
+الأرقام اللي بنذكرها مش بالضرورة تبقى هي نفس
+
+381
+00:27:34,690 --> 00:27:38,810
+الأرقام اللي اتعلمناها ايامالدراسة قد تتغير و لازم
+
+382
+00:27:38,810 --> 00:27:43,690
+يكون المفهوم لدينا ان هذا التغير مبرر بانه صار فيه
+
+383
+00:27:43,690 --> 00:27:48,710
+intervention من قبل البشر او تغير معين لما عملنا
+
+384
+00:27:48,710 --> 00:27:53,810
+ال vaccine كانت الربيلة رقم واحد في ال congenital
+
+385
+00:27:53,810 --> 00:27:56,270
+abnormality عملنا ال vaccine صار مين ال number
+
+386
+00:27:56,270 --> 00:28:00,310
+one؟ سايتون ميجالو فيروس هذا المقصود في changing
+
+387
+00:28:00,310 --> 00:28:04,570
+epidemiology او تلقاء اللي بيانRubella is a milder
+
+388
+00:28:04,570 --> 00:28:11,550
+يعني أخف shorter فترة المرض أقصر disease than
+
+389
+00:28:11,550 --> 00:28:16,150
+measles دايما بنقارن Rubella بمين بالميسلز after
+
+390
+00:28:16,150 --> 00:28:18,710
+an incubation period of fourteen to twenty one
+
+391
+00:28:18,710 --> 00:28:23,110
+days a brief prodromal period of fever and malaise
+
+392
+00:28:23,110 --> 00:28:27,230
+is followed by maculopapular rashes اللي هو نفس
+
+393
+00:28:27,230 --> 00:28:32,510
+الرش تبع مين؟ الميسلزببدأ برضه بال face و بينتقل
+
+394
+00:28:32,510 --> 00:28:37,810
+الى الجسم و من ثم الى اليدين ايش اختلاف طبعا عن ال
+
+395
+00:28:37,810 --> 00:28:42,970
+missiles اختلاف ايش ايه؟ فيه حد ما ذكرناهاش هنا و
+
+396
+00:28:42,970 --> 00:28:46,690
+ذكرناها في ال missiles مين بتذكرها؟
+
+397
+00:28:50,330 --> 00:28:55,050
+كوبليك سبوت هي الإحمرار اللى موجود فى الـbuccal
+
+398
+00:28:55,050 --> 00:28:58,570
+cavity، النقاط الحمرة، الـspots تمام؟ الحمرة اللى
+
+399
+00:28:58,570 --> 00:29:03,250
+فىها white dots، كمان فىها نقاط بيضاء، قولنا عنها
+
+400
+00:29:03,250 --> 00:29:07,390
+هادي characteristic للميسلز، غير موجود فى مين؟ فى
+
+401
+00:29:07,390 --> 00:29:11,950
+ال German missiles أو فى الربينةPosterior
+
+402
+00:29:11,950 --> 00:29:16,330
+Auricular Lymphadenopathy is characteristics هنا
+
+403
+00:29:16,330 --> 00:29:21,570
+هنا إذا بكتبها في ان روبيللا دائما و أبدا في
+
+404
+00:29:21,570 --> 00:29:25,810
+انتفاخ ورا الأذن هذا معناه لـ posterior auricular
+
+405
+00:29:25,810 --> 00:29:28,810
+lymphadenopathy الانتفاخ هنا نتجة عن ال swelling
+
+406
+00:29:28,810 --> 00:29:33,150
+في ال lymph node الموجودة في المنطقة ورا الأذن هذه
+
+407
+00:29:33,150 --> 00:29:37,090
+ال characteristics وجودها تقريبا وجودها يعني
+
+408
+00:29:37,090 --> 00:29:43,180
+روبيللا مع شوية trash معناها روبيللاوصلت؟ The rash
+
+409
+00:29:43,180 --> 00:29:46,160
+typically lasts for three days، short period، يعني
+
+410
+00:29:46,160 --> 00:29:49,680
+فترة قصيرة، when rubella occurs in adults، لما
+
+411
+00:29:49,680 --> 00:29:53,700
+تصير في الناس البالغين especially women،
+
+412
+00:29:53,700 --> 00:29:57,800
+polyarthritis، ايش يعني polyarthritis؟ كل المفاصل
+
+413
+00:29:57,800 --> 00:30:01,420
+الان في المفاصل بشكل عام، نتيجة عن ايش ال
+
+414
+00:30:01,420 --> 00:30:05,480
+polyarthritis؟ Antigen-antibody complexes،
+
+415
+00:30:05,480 --> 00:30:07,560
+deposition في هذه المفاصل
+
+416
+00:30:10,330 --> 00:30:15,830
+Congenital Rubella Syndrome بيسموها Teratogen أي
+
+417
+00:30:15,830 --> 00:30:21,350
+مُركّب بيأثر على الأجنة بيسميه Teratogen.Pregnant
+
+418
+00:30:21,350 --> 00:30:27,630
+woman is infected during the first trimester.الأول
+
+419
+00:30:27,630 --> 00:30:34,050
+تلت شهور.Especially the first month significant
+
+420
+00:30:34,050 --> 00:30:38,650
+congenital malformation can occur.إذا كان في الشهر
+
+421
+00:30:38,650 --> 00:30:43,930
+الأولأسوأ من الشهر الثاني أسوأ أسوأ من الشهر
+
+422
+00:30:43,930 --> 00:30:47,290
+الثاني يعني بمعنى أخر كل ما اتقدمنا بيخف الضرر لأ
+
+423
+00:30:47,290 --> 00:30:53,110
+بيخف الضرر البداية هي الأسوأ البداية هي الأسوأ the
+
+424
+00:30:53,110 --> 00:30:55,330
+increased rate of abnormalities during the early
+
+425
+00:30:55,330 --> 00:30:58,310
+weeks of pregnancy is attributed to the very
+
+426
+00:30:58,310 --> 00:31:01,350
+sensitive organ development that occurred at that
+
+427
+00:31:01,350 --> 00:31:06,950
+time طبعا انتوا عارفين انه في بداية التكون التخصيب
+
+428
+00:31:06,950 --> 00:31:11,290
+الجنين ال zygoteالانقسام مش بيكون .. بيكون أسرع من
+
+429
+00:31:11,290 --> 00:31:15,470
+البرج، يعني انقسام سريع وهذه مرحلة حساسة wherein
+
+430
+00:31:15,470 --> 00:31:19,590
+organ development starts فلما الفيروس يكون في هذه
+
+431
+00:31:19,590 --> 00:31:23,830
+المرحلة .. تذكروا المقولة طبعتنا الشهيرة أنه كل ما
+
+432
+00:31:23,830 --> 00:31:28,190
+كان العمل كثير، كل ما كان الخطأ كثير فالفيروس
+
+433
+00:31:28,190 --> 00:31:33,910
+بيكون مشط جدا مع هذه أيضا الخلايا وبالتالي بالفعل
+
+434
+00:31:33,910 --> 00:31:40,320
+بيكون الضرر عالي جداإذا هذه المرحلة مرحلة ال organ
+
+435
+00:31:40,320 --> 00:31:44,280
+development، the malformations are widespread يعني
+
+436
+00:31:44,280 --> 00:31:49,240
+مش بتكون في عضو معين، بتكون في أعضاء متنوعة and
+
+437
+00:31:49,240 --> 00:31:52,460
+can involve primarily the heart, the eyes and the
+
+438
+00:31:52,460 --> 00:31:58,320
+brain، إذا في أعضاء مختلفة لكن أهمها بالنسبة لنا
+
+439
+00:31:58,320 --> 00:32:03,020
+اللي هو القلب والعينين والدماغIn addition, some
+
+440
+00:32:03,020 --> 00:32:12,520
+children infected in utero
+
+441
+00:32:12,520 --> 00:32:18,260
+can continue to execrate rubella virus for months
+
+442
+00:32:18,260 --> 00:32:19,640
+following birth
+
+443
+00:32:22,040 --> 00:32:25,760
+إن ولد وكانت أمه مصابة ونقلته الفيروس حتى وان لم
+
+444
+00:32:25,760 --> 00:32:30,700
+يبدو عليه أي أعراض هو نفسه بيكون مصدر للفيروس لعدة
+
+445
+00:32:30,700 --> 00:32:35,390
+أشهر يعني بيعمل secretion لهذا الفيروسبعض الـ
+
+446
+00:32:35,390 --> 00:32:40,730
+congenital shaders يعني المفرزين، يشدوا الفيروس،
+
+447
+00:32:40,730 --> 00:32:44,290
+يعني هم ينتجوا الفيروس، هم يفرزوا الفيروس، هم
+
+448
+00:32:44,290 --> 00:32:47,490
+أسيمتوماتيكيين و ليسوا مالفورماتيين، كل هذا ما
+
+449
+00:32:47,490 --> 00:32:49,810
+حكيناه، قولنا لكوا أنه سواء كان عنده مالفورماتيين
+
+450
+00:32:49,810 --> 00:32:53,570
+أو ما عندهوش، مالفورماتيين ممكن ينتج الفيروس
+
+451
+00:32:53,570 --> 00:32:58,860
+ويعمله spreadand hence can be diagnosed only if
+
+452
+00:32:58,860 --> 00:33:03,560
+the virus is isolated يعني مايقدرش نعرف إنه هذا
+
+453
+00:33:03,560 --> 00:33:08,540
+مصاب إلا إذا احنا جمنا بعازل إيه؟ اللي هو الفيروس
+
+454
+00:33:08,540 --> 00:33:14,220
+و طبعا واحد apparently healthyهل هناك داعي ان
+
+455
+00:33:14,220 --> 00:33:19,140
+نفحصه للروبيلا؟ إلا إذا الأم أظهرت symptoms لمن؟
+
+456
+00:33:19,140 --> 00:33:23,060
+للروبيلا، فبالتالي المولود حتى وإن كان healthy، he
+
+457
+00:33:23,060 --> 00:33:26,740
+should be investigated for جنة اللي هو الروبيلا
+
+458
+00:33:45,680 --> 00:33:53,070
+الأطفال اللي بنولدوا و عندهمإصابة بالروبيلا بيكون
+
+459
+00:33:53,070 --> 00:33:57,550
+عندهم IgM و IgG that can last for longer periods
+
+460
+00:33:57,550 --> 00:34:00,970
+احنا بنلاحظ انه على 6 شهور ل 15 شهر بتختفي ال
+
+461
+00:34:00,970 --> 00:34:05,410
+maternal antibody لها ده ال virus لكن المصابين لأ
+
+462
+00:34:05,410 --> 00:34:10,910
+بيضال عندهم لفترات طويلة ال lab diagnosis روبيلا
+
+463
+00:34:10,910 --> 00:34:14,530
+virus can be grown in cell culture with little
+
+464
+00:34:14,530 --> 00:34:20,440
+cytopathic effect يعني مالهاش CPE واضحعادةً يتم
+
+465
+00:34:20,440 --> 00:34:24,360
+اكتشافها باستخدام قدرتها على الانتفاق مع الـ
+
+466
+00:34:24,360 --> 00:34:30,260
+ECOVIRUS-CPE. إيش هينتفير مع الـ ECOVIRUS-CPE؟ لأن
+
+467
+00:34:30,260 --> 00:34:33,820
+الـ ECOVIRUS يا بنات، هذا إيه اللي هو الـ CPE؟
+
+468
+00:34:33,820 --> 00:34:37,100
+زراعنا عصر الكرشة بيعمل الـ CPE، دايما بيعمل نفس
+
+469
+00:34:37,100 --> 00:34:42,740
+الـ CPEلو زرعت معاه روبيلا بيمنع ال eco virus من
+
+470
+00:34:42,740 --> 00:34:48,380
+انه يعمل CPE فبنتعرف على الربيلا من خلال منعه لل
+
+471
+00:34:48,380 --> 00:34:53,960
+eco virus CPE فسموه interference testإذا كانت
+
+472
+00:34:53,960 --> 00:34:57,960
+روبيلا بياس موجودة في مصطلح الشخص، وكانت مبتدئة في
+
+473
+00:34:57,960 --> 00:35:01,700
+ثلاجة ثقافات، فلا CPE سيظهر عندما تكون الثقافة
+
+474
+00:35:01,700 --> 00:35:04,580
+مصابة بالإنفاق مع إيكو بياس
+
+475
+00:35:11,690 --> 00:35:15,830
+كمان طريقة أخرى في ال diagnosis هو الأنشودة
+
+476
+00:35:15,830 --> 00:35:20,710
+المعروفة صارت أنه الإرتفاع بأربعة أضعاف أو أكثر في
+
+477
+00:35:20,710 --> 00:35:24,190
+مستوى ال antibody ما بين عينة ال acute ما بين عينة
+
+478
+00:35:24,190 --> 00:35:27,370
+اللي هو ال convalescent serum هو المرة المليون
+
+479
+00:35:27,370 --> 00:35:32,170
+جونالكو البعض بيظن أن هذا النوع من الفحصات ليس له
+
+480
+00:35:32,170 --> 00:35:37,790
+أي قيمة للمريض لإله قيمة إله قيمة أنهيعني عملنا
+
+481
+00:35:37,790 --> 00:35:42,330
+confirm للحالة انه سجلناها رقم اتنين انه لو ماصارش
+
+482
+00:35:42,330 --> 00:35:44,750
+فيه increase يا جماعة مانا الحاجة ان المريض ممكن
+
+483
+00:35:44,750 --> 00:35:49,070
+يكون مريض بمرض اخر وبالتالي لازم نبحث عن هذا
+
+484
+00:35:49,070 --> 00:35:52,710
+المرض، اذا to confirm a case is an essential
+
+485
+00:35:52,710 --> 00:35:57,130
+diagnostic requirement for epidemiological reason
+
+486
+00:35:57,130 --> 00:36:01,920
+وممكن for the sake of the patient بعض الأحيانBy
+
+487
+00:36:01,920 --> 00:36:06,540
+observing the presence of IgM antibody in a single
+
+488
+00:36:06,540 --> 00:36:10,560
+acute phase serum sample يعني ال IGG هو اللي بده
+
+489
+00:36:10,560 --> 00:36:14,800
+four fold increase لكن لو دورنا ع ال IgM و طبعا
+
+490
+00:36:14,800 --> 00:36:19,200
+لأن الربلة من الفحوصات اللي لها علاقة بال abortion
+
+491
+00:36:19,570 --> 00:36:24,190
+و بـ Pregnancy ففي غزة هانا لابد انها تكون متوفرة
+
+492
+00:36:24,190 --> 00:36:28,310
+في كل مكان لان احنا شعب بيحب اللي هو يعني مايصيرش
+
+493
+00:36:28,310 --> 00:36:31,730
+عنده abortion و انه يكون عنده يعني او يعرف سبب
+
+494
+00:36:31,730 --> 00:36:34,210
+عشان المرأة القادمة مايصيرش في عندنا abortion
+
+495
+00:36:34,210 --> 00:36:38,190
+الربلة واحدة من مسببات ال abortion و ال congenital
+
+496
+00:36:38,190 --> 00:36:41,910
+abnormality و ربما يكون ال failure في ال IVF اللي
+
+497
+00:36:41,910 --> 00:36:45,330
+هي زراعة الجنة in vitro
+
+498
+00:36:48,360 --> 00:36:51,640
+In a pregnant woman exposed to rubella virus, the
+
+499
+00:36:51,640 --> 00:36:54,980
+presence of IgM antibody indicates recent
+
+500
+00:36:54,980 --> 00:36:55,420
+infection
+
+501
+00:37:03,110 --> 00:37:07,690
+Whereas one to eight or greater titers of IgG
+
+502
+00:37:07,690 --> 00:37:11,150
+antibody indicates immunity and consequent
+
+503
+00:37:11,150 --> 00:37:16,030
+protection of the fetus يعني لو لجينا عند السيدة
+
+504
+00:37:16,030 --> 00:37:21,230
+تائتر من IgG واحد ل تمانية تمام واحد على تمانية
+
+505
+00:37:21,230 --> 00:37:24,910
+يعني احنا بيقولكوا واحد نص ربع تمان واحد على ستاشر
+
+506
+00:37:24,910 --> 00:37:27,810
+واحد اتنين و تلاتين اذا لجينا واحد على تمانية او
+
+507
+00:37:27,810 --> 00:37:30,130
+اقل اللي هو واحد على ستاشر او واحد على
+
+508
+00:37:33,550 --> 00:37:39,910
+السيدة لديها انتباد كافي وبالتالي هي محافظة من أن
+
+509
+00:37:39,910 --> 00:37:42,070
+تنصب بي الربان
+
+510
+00:37:47,190 --> 00:37:50,130
+أمينو سنتسيز امينو سنتسيز اللي هو الحصول على
+
+511
+00:37:50,130 --> 00:37:55,510
+السائل الجنيني سائل الجنيني can reveal whether
+
+512
+00:37:55,510 --> 00:37:58,490
+there is a rubella virus in the amniotic fluid
+
+513
+00:37:58,490 --> 00:38:03,110
+which indicate definite fetal infection كلمة fetal
+
+514
+00:38:03,110 --> 00:38:07,370
+infection يعني الإصارة في الجنين سوف تؤكد من خلال
+
+515
+00:38:07,370 --> 00:38:14,860
+هذا الفحص طبعا هذا أيضا يعني برضه فحص جيدلان احنا
+
+516
+00:38:14,860 --> 00:38:18,960
+بنعرف ان الطفل مصاب او غير مصاب قبل حتى قبل خروجه
+
+517
+00:38:18,960 --> 00:38:24,920
+الى الحياة treatment there is no antiviral therapy
+
+518
+00:38:24,920 --> 00:38:28,880
+ال prevention involves immunization with live
+
+519
+00:38:28,880 --> 00:38:32,120
+attenuated vaccine كلكم عارفين ان هو جزء من مين؟
+
+520
+00:38:32,120 --> 00:38:37,740
+من طلعة اللي هو ال MMA produces at least 10 years
+
+521
+00:38:37,740 --> 00:38:42,310
+of immunity بعطينا عشرة سنوات تقريبا من المنامIt
+
+522
+00:38:42,310 --> 00:38:46,650
+is given subcutaneously to children at 15 months
+
+523
+00:38:46,650 --> 00:38:49,790
+of age و احنا ذكرنا ليش 15 month لأنه بيقولنا لكوا
+
+524
+00:38:49,790 --> 00:38:52,490
+ان ال .. ال .. ال maternal antibody بتكون موجودة و
+
+525
+00:38:52,490 --> 00:38:56,490
+protective ليدا الطفل It is also given to
+
+526
+00:38:56,490 --> 00:39:00,470
+unimmunized young adult women if they are not
+
+527
+00:39:00,470 --> 00:39:05,690
+pregnant يعني مش خلال الحمل و انما قبل الحملand
+
+528
+00:39:05,690 --> 00:39:09,310
+will use contraceptive for the next three months
+
+529
+00:39:09,310 --> 00:39:13,270
+يعني مضمون إنها ما تحملش كمان تلت شهور، تمام؟ يعني
+
+530
+00:39:13,270 --> 00:39:17,930
+بدناش نعطيها ال vaccine و تحمل بكرا أو تحمل
+
+531
+00:39:17,930 --> 00:39:22,170
+الأسبوع اللي جاي، ليش؟ لأنه لسه .. لأن هذا live
+
+532
+00:39:22,170 --> 00:39:26,670
+attenuated ال virus، صح؟ هممكن ننتقل لمين؟ للجنين
+
+533
+00:39:26,670 --> 00:39:31,470
+اللي عملنا real infectionلا يوجد اي اثبات ان
+
+534
+00:39:31,470 --> 00:39:38,870
+الفيروس يسبب فيه مالفورميشن، لكن للخشية والنظرية
+
+535
+00:39:38,870 --> 00:39:42,430
+اللي بنالكوا عنها لما اتكلمنا عن ال live vaccine و
+
+536
+00:39:42,430 --> 00:39:45,550
+ال killed vaccine ابنها، احد المخاوف اللي ذكرناها
+
+537
+00:39:45,550 --> 00:39:49,450
+ان ال live ال attenuated is to revert to the
+
+538
+00:39:49,450 --> 00:39:53,620
+active formهذه مخاوف نظرية لم نراها إلا أظن مرة
+
+539
+00:39:53,620 --> 00:39:58,280
+واحدة في ال polio vaccine وقلنا لكوا يعني هذا ممكن
+
+540
+00:39:58,280 --> 00:40:02,320
+تخيل احنا بنحتفل قاعدين انه انتهينا من مين؟ من ال
+
+541
+00:40:02,320 --> 00:40:07,060
+polio و بعدين نرجع مرة تانية ل polio disease
+
+542
+00:40:09,730 --> 00:40:12,170
+Because it is a live vaccine, it should not be
+
+543
+00:40:12,170 --> 00:40:14,770
+given to immunocompromised patients or to pregnant
+
+544
+00:40:14,770 --> 00:40:18,050
+women. The vaccine has caused a significant
+
+545
+00:40:18,050 --> 00:40:21,290
+reduction in the incidence of both rubella and
+
+546
+00:40:21,290 --> 00:40:23,490
+congenital rubella syndrome
+
+547
+00:40:29,490 --> 00:40:35,850
+It induces respiratory IgA و احنا قلنا لكم ان ال
+
+548
+00:40:35,850 --> 00:40:40,950
+IgA كتير مهم في هذا النوع من الفيروسات لان معظم ال
+
+549
+00:40:40,950 --> 00:40:44,690
+transmission بيتم عبر اللي هو ال respiratory tract
+
+550
+00:40:44,690 --> 00:40:48,890
+Immune serum globulin can be given to pregnant
+
+551
+00:40:48,890 --> 00:40:51,990
+women in the first trimester who have been exposed
+
+552
+00:40:51,990 --> 00:41:00,540
+to a known case of rubellaسيدة حامل و راحت زهرت
+
+553
+00:41:00,540 --> 00:41:03,660
+جديبتها
+
+554
+00:41:03,660 --> 00:41:09,340
+صاحبتها واكتشفت ان صاحبتها اصلا عندها حصب علماني
+
+555
+00:41:09,340 --> 00:41:14,040
+او تعارض لابنت صاحبتها او ابن صاحبتها المصاب من
+
+556
+00:41:14,040 --> 00:41:18,360
+بالربل يعني ايش معناه؟ ايش .. ايش .. ايش هي وضعها؟
+
+557
+00:41:18,360 --> 00:41:25,820
+exposed صارت هي معرضة و حاملبنجرش نعطيها فاكسين؟
+
+558
+00:41:25,820 --> 00:41:28,460
+نجرش نعطيها فاكسين، إيش مانعطيها في هذه الحالة؟
+
+559
+00:41:28,460 --> 00:41:33,060
+immunoglobulin تمام؟ to protect her and to protect
+
+560
+00:41:33,060 --> 00:41:35,320
+her baby في هذه الحالة
+
+561
+00:41:39,330 --> 00:41:42,330
+Immune serum globulin can be given to pregnant
+
+562
+00:41:42,330 --> 00:41:45,250
+women in the first trimester who have been exposed
+
+563
+00:41:45,250 --> 00:41:49,250
+to a known case of rubella and for whom
+
+564
+00:41:49,250 --> 00:41:53,750
+termination of pregnancy is not an option.طبعا
+
+565
+00:41:53,750 --> 00:41:59,230
+انتوا عارفين الإجهاد عند الأجانب في بعض الدول
+
+566
+00:41:59,230 --> 00:42:02,090
+مشروعة يعني هو مرتبط أنه يحصل فيه إجهاد حتى لو
+
+567
+00:42:02,090 --> 00:42:06,390
+بناها توقع تمام فبيقولك انه في حالة انه
+
+568
+00:42:12,200 --> 00:42:20,660
+المشكلة الرئيسية في الـ immunoglobulin هي أن هناك
+
+569
+00:42:20,660 --> 00:42:26,180
+حاجة فيها التي لا تنجح لإيقاف التأثير الفيطاليعلى
+
+570
+00:42:26,180 --> 00:42:30,820
+الرغم من النجاحات اللي حققها إلا إن هناك حالات فشل
+
+571
+00:42:30,820 --> 00:42:38,160
+ال immunoglobulin أن يحدث منأ للإصابة بال fetal أو
+
+572
+00:42:38,160 --> 00:42:41,740
+ال congenital rebel، إذا مش hundred percent
+
+573
+00:42:45,600 --> 00:43:02,140
+الجملة الأخيرة أو الفقرة الأخيرة تخيلوا
+
+574
+00:43:02,140 --> 00:43:06,280
+للممرض و لطبيب عنده Rubella و خاصة في النساء
+
+575
+00:43:06,280 --> 00:43:11,080
+والولادةاللي بيرجعوا عندهم النساء والحيوانات،
+
+576
+00:43:11,080 --> 00:43:15,680
+مشكلة كبيرة لو ده لأ، لذلك إيش سياسة المستشفى؟
+
+577
+00:43:15,680 --> 00:43:20,780
+سياسة المستشفى إنه لازم يجيب شهادة إنه مطعم أو فحص
+
+578
+00:43:20,780 --> 00:43:24,660
+إنه بيحتوي على اللي هو immunoglobulin بشكل عالي،
+
+579
+00:43:24,660 --> 00:43:30,460
+إنه protectedعشان برضه نمنع اللى هو او نكسر ال
+
+580
+00:43:30,460 --> 00:43:34,820
+cycle اللى ممكن تؤدي الى انتقاد ال virus من ال
+
+581
+00:43:34,820 --> 00:43:38,340
+personnel الى ال .. ال .. ال .. النساء الى حوالى
+
+582
+00:43:38,340 --> 00:43:41,580
+المرة الجاية ان شاء الله بنكمل الفقرات اللى باقية
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg.srt
new file mode 100644
index 0000000000000000000000000000000000000000..25467fffbfe5575ff5577c3454829c6402f26dfb
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg.srt
@@ -0,0 +1,2333 @@
+1
+00:00:21,130 --> 00:00:23,490
+فبسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:23,490 --> 00:00:29,030
+اليوم إن شاء الله هو الـ clinical virology و
+
+3
+00:00:29,030 --> 00:00:32,410
+clinical virology يعني نتكلم عن الفيروسات و نتكلم 
+
+4
+00:00:32,410 --> 00:00:35,490
+عن الأمراض و عن الـ mechanism by which they
+
+5
+00:00:35,490 --> 00:00:38,650
+produce the disease و عن الـ treatment و عن الـ
+
+6
+00:00:38,650 --> 00:00:42,270
+prevention و أيضًا عن الـ diagnosis يعني هي عبارة عن
+
+7
+00:00:42,270 --> 00:00:46,290
+diagnostic virology أو medical virology. هنبدأ إن 
+
+8
+00:00:46,290 --> 00:00:50,350
+شاء الله بالـ DNA enveloped viruses كما قسمنا
+
+9
+00:00:50,350 --> 00:00:52,430
+البكتيريا في السابق إلى gram positive و gram
+
+10
+00:00:52,430 --> 00:00:56,730
+negative وبسيلايكوكساي هنا بنقسمها إلى DNA viruses
+
+11
+00:00:56,730 --> 00:01:01,670
+و RNA viruses enveloped و non enveloped. فبصينا دي 
+
+12
+00:01:01,670 --> 00:01:05,710
+أربع نوع رئيسية: DNA enveloped، DNA non enveloped،
+
+13
+00:01:05,710 --> 00:01:08,950
+RNA enveloped، و RNA non enveloped. هذا إن شاء الله 
+
+14
+00:01:08,950 --> 00:01:15,830
+بمجموعة مهمة ليها. DNA enveloped virus. وأول فرد في
+
+15
+00:01:15,830 --> 00:01:19,730
+هذه المجموعة عائلة نسميها Herpes Viruses Family.
+
+16
+00:01:21,070 --> 00:01:24,930
+وكونها family بيبقى فيها أعضاء كثر، ومن أشهر
+
+17
+00:01:24,930 --> 00:01:28,130
+الأعضاء اللي موجودين أمامنا الـ herpes simplex type
+
+18
+00:01:28,130 --> 00:01:32,630
+1 وهو صديق ملازم لكثير من البشر. الـ herpes simplex
+
+19
+00:01:32,630 --> 00:01:36,590
+type 2 هذا ليس صديق، صديق إلا للعصار، لأنه هذا بينتقل
+
+20
+00:01:36,590 --> 00:01:40,510
+عن طريق الـ genes. رقم تلاتة الـ varicella zoster
+
+21
+00:01:40,510 --> 00:01:43,950
+virus. وهذا في يوم من الأيام كنا عانينا منه أو 
+
+22
+00:01:43,950 --> 00:01:46,730
+معظمنا عانينا منه، اللي هو الجدري المائي اللي بيسمونه
+
+23
+00:01:46,730 --> 00:01:50,380
+جدري المائي أو chicken pox. ويمكن لما نكبر في السن 
+
+24
+00:01:50,380 --> 00:01:55,700
+شوية، نصير نعاني من مين؟ من اللي هو الـ exhaust. رقم 
+
+25
+00:01:55,700 --> 00:02:00,440
+أربعة. أطباء النساء والولادة بيخافوا كثير من هذا
+
+26
+00:02:00,440 --> 00:02:04,100
+الفيروس لإنه أحد الفيروسات اللي بتسبب congenital
+
+27
+00:02:04,100 --> 00:02:08,040
+abnormalities. وشوفنا في الـ classification of
+
+28
+00:02:08,040 --> 00:02:12,940
+medically important viruses أن الـ CMV بينتقل من
+
+29
+00:02:12,940 --> 00:02:15,780
+الأم إلى الجنين، الجنين عبر الـ placenta خلال
+
+30
+00:02:15,780 --> 00:02:20,920
+الحمل. وقد ينتقل خلال أعمال الولادة، وقد ينتقل من
+
+31
+00:02:20,920 --> 00:02:26,960
+الحليب عند الرضاعة. إذا بتذكروا أن الطفل محاصر
+
+32
+00:02:26,960 --> 00:02:32,060
+بالثلاثة اتجاهات. رقم خمسة، بيشتغل فيروس، بيشتغل فيروس
+
+33
+00:02:32,060 --> 00:02:32,300
+بيشتغل فيروس بيشتغل فيروس بيشتغل فيروس بيشتغل
+
+34
+00:02:32,300 --> 00:02:34,400
+بيروس بيشتغل فيروس بيشتغل فيروس بيشتغل فيروس
+
+35
+00:02:34,400 --> 00:02:36,020
+بيشتغل فيروس بيشتغل فيروس بيشتغل فيروس بيشتغل
+
+36
+00:02:36,020 --> 00:02:38,060
+بيشتغل فيروس بيشتغل فيروس بيشتغل فيروس بيشتغل
+
+37
+00:02:38,060 --> 00:02:41,340
+بيشتغل فيروس بيشتغل فيروس بيشتغل فيروس بيشتغل
+
+38
+00:02:41,340 --> 00:02:48,920
+بيشتغل فيروس بسرطان مشهور ومرتبط إما بالـ AIDS أو 
+
+39
+00:02:48,920 --> 00:02:53,660
+بذوي المناعة المنخفضة، بسموه Kaposi's Sarcoma، سرطان
+
+40
+00:02:53,660 --> 00:03:00,780
+كابوسي كمان، وأصبح من الشيوع بدرجة أنه لو رأينا
+
+41
+00:03:00,780 --> 00:03:05,780
+إنسان عنده Kaposi's Sarcoma نقول أنه HIV. إذا
+
+42
+00:03:05,780 --> 00:03:09,940
+مجموعة ضخمة من الفيروسات مهمة ومنتشرة بشكل كبير.
+
+43
+00:03:09,940 --> 00:03:14,920
+يعني أعطيكم مثال مثلًا رقم تلاتة، الـ الفارسيلازوستر
+
+44
+00:03:14,920 --> 00:03:20,540
+في الولايات المتحدة قبل 2001 كان يعتبر the most
+
+45
+00:03:20,540 --> 00:03:24,620
+common notifiable disease. إيش يعني the most common
+
+46
+00:03:24,620 --> 00:03:29,380
+notifiable disease؟ الآن في أمراض إحنا بنسميها
+
+47
+00:03:29,380 --> 00:03:32,580
+notifiable diseases، يعني يجب الإبلاغ عنها، يجب
+
+48
+00:03:32,580 --> 00:03:36,800
+الإبلاغ عنها، إيش يجب الإبلاغ عنها؟ أنا بقى أزلت 
+
+49
+00:03:36,800 --> 00:03:41,740
+post على الفيسبوك، شفتوا يمكن صارت تعوون في مجلد
+
+50
+00:03:41,740 --> 00:03:46,660
+أشقر. التعوون internationally notifiable disease، 
+
+51
+00:03:46,660 --> 00:03:49,580
+يعني لو صارت حالة في أي دولة في الدنيا، يجب أن 
+
+52
+00:03:49,580 --> 00:03:53,000
+تعلم عنها منظمة الصحة العالمية، يجب أن تبلغ هذه
+
+53
+00:03:53,000 --> 00:03:58,040
+الجهة منظمة الصحة العالمية. فكلمة notifiable يعني
+
+54
+00:03:58,040 --> 00:04:02,120
+يجب الإبلاغ عنه. فبنقول إن chickenpox كان one of
+
+55
+00:04:02,120 --> 00:04:04,100
+the most common أو the most common notifiable
+
+56
+00:04:04,100 --> 00:04:09,010
+disease في الولايات المتحدة وإن في كل العالم. الـ
+
+57
+00:04:09,010 --> 00:04:11,870
+Common Characteristics للعائلة للـ Herpes Virus
+
+58
+00:04:11,870 --> 00:04:17,530
+Family بشكل عام أنه كلها كأفراد شكلًا تشبه بعضها
+
+59
+00:04:17,530 --> 00:04:19,950
+البعض، يعني صعب نميز بينها بالـ electron
+
+60
+00:04:19,950 --> 00:04:23,650
+microscope. رقم اتنين، They are Ecosahedral،
+
+61
+00:04:23,650 --> 00:04:27,470
+Ecosahedral يعني عشروني الوجوه. Surrounded by a
+
+62
+00:04:27,470 --> 00:04:33,280
+lipoprotein envelope، وهذا الـ envelope هو الوحيد
+
+63
+00:04:33,280 --> 00:04:37,000
+الذي أُخذ من الـ nuclear membrane وليس من الـ cell
+
+64
+00:04:37,000 --> 00:04:40,420
+membrane. تمام؟ يبقى الـ herpes virus family تميزت
+
+65
+00:04:40,420 --> 00:04:44,220
+بإن الـ envelope تبعها من الـ nucleus وليس من الـ
+
+66
+00:04:44,220 --> 00:04:49,680
+cytoplasm. they do not contain a polymerase، يعني 
+
+67
+00:04:49,680 --> 00:04:52,900
+بتطلع نظيفة من الخلية وبتروح الخلية مش حاملة معاها
+
+68
+00:04:52,900 --> 00:04:56,580
+حاجة، تمام؟ لا بتاخد هدية ولا بتحمل هدايا، مافيش
+
+69
+00:04:56,580 --> 00:05:00,680
+polymerase، مافيش polymerase. عارفين ليش؟ لأنه DNA
+
+70
+00:05:00,680 --> 00:05:04,460
+فيروس وبتكاتر في النواة. وبعدين بتكاتر في النواة
+
+71
+00:05:04,460 --> 00:05:09,440
+يبقى هياخد كل الأدوات بتاعة التكاثر. وحنعرف من
+
+72
+00:05:09,440 --> 00:05:14,700
+ذكائه إنه إذا أراد دخول الخلية وعدم الإعلان عن
+
+73
+00:05:14,700 --> 00:05:18,240
+نفسه، يعني common وهي صفة من صفات الـ herpes virus
+
+74
+00:05:18,240 --> 00:05:23,790
+family لا يدخل إلى النواة، يبقى وين؟ في الـ cytoplasm.
+
+75
+00:05:23,790 --> 00:05:26,950
+إذا بقى في الـ cytoplasm لا حيصير له replication
+
+76
+00:05:26,950 --> 00:05:29,810
+ولا حيصير له transcription ولا حيصير له
+
+77
+00:05:29,810 --> 00:05:34,470
+translation، وبالتالي مافيش protein تطلع منه تلتصق
+
+78
+00:05:34,470 --> 00:05:37,710
+بالـ membrane الخارجي للخلية المصابة. يبقى
+
+79
+00:05:37,710 --> 00:05:42,070
+الـ cytotoxic T cell ستمر على هذه الخلية ولم تعرف أن
+
+80
+00:05:42,070 --> 00:05:47,150
+هناك فيروس يقطن داخلها. إذن هي حركة ذكية منه إنه
+
+81
+00:05:47,150 --> 00:05:50,330
+يبقى وين؟ في الـ cytoplasm، في حالة الكمون، في حالة
+
+82
+00:05:50,330 --> 00:05:55,020
+الكمون. Double-stranded DNA does not contain
+
+83
+00:05:55,020 --> 00:05:59,680
+polymerase. بنسبة الحجم تبعه يعتبر الثاني في
+
+84
+00:05:59,680 --> 00:06:02,940
+الترتيب بعد الـ pox viruses. الـ pox viruses اللي 
+
+85
+00:06:02,940 --> 00:06:06,180
+منها الـ smallpox والفاكسينيا فيروس، أكبر في عيوسته.
+
+86
+00:06:06,180 --> 00:06:10,910
+إحنا المحاضرة السابقة لما اتكلمنا عن الـ viruses to
+
+87
+00:06:10,910 --> 00:06:14,730
+vaccinate against viruses، يعني نستخدم فيروس لما 
+
+88
+00:06:14,730 --> 00:06:17,390
+نعمل طعم ضد فيروسات أخرى، سخدعنا الـ vaccinia
+
+89
+00:06:17,390 --> 00:06:22,890
+virus لأن حجمه كبير، أدواته، الجينات تبعته كثيرة
+
+90
+00:06:22,890 --> 00:06:27,530
+وبتلا ممكن نستبدلها بجينات أخرى. إذن هو الـ herpes
+
+91
+00:06:27,530 --> 00:06:31,470
+virus هو الثاني في الحجم بعد مين؟ بعد الـ pox virus.
+
+92
+00:06:33,150 --> 00:06:36,410
+الـ Replication كنا بتم في النوكلياس وبيكون انترا
+
+93
+00:06:36,410 --> 00:06:40,550
+نوكليار انكلوجين. يعني لو طلعنا تحت الميكروسكوب على
+
+94
+00:06:40,550 --> 00:06:45,290
+خلية مصابة هنلاقي بقايا الفيروس وين موجودة في
+
+95
+00:06:45,290 --> 00:06:49,810
+النوكلياس، اسمه انترا نوكليار انكلوجين. bodies are
+
+96
+00:06:49,810 --> 00:06:54,710
+the only viruses that obtain their envelope by
+
+97
+00:06:54,710 --> 00:06:58,230
+budding from the nuclear membrane. أعتقد أنه خلصها
+
+98
+00:06:58,230 --> 00:07:00,630
+من المعلومة دي أن هي الوحيدة اللي بتاخد من الـ
+
+99
+00:07:00,630 --> 00:07:06,320
+nuclear membrane. فيها tegument والتجمينت هو البروتين
+
+100
+00:07:06,320 --> 00:07:10,780
+اللي ما بين الكبسيد وما بين الـ envelope. وقلنا وظيفة
+
+101
+00:07:10,780 --> 00:07:16,080
+الـ tegument أنها مخزن لـ regulatory proteins. وكلمة
+
+102
+00:07:16,080 --> 00:07:18,700
+regulatory proteins هي البروتينات اللي بتعمل
+
+103
+00:07:18,700 --> 00:07:21,920
+regulation مثلًا لترانسكيبشن وترانسليشن، بسموها
+
+104
+00:07:21,920 --> 00:07:25,920
+transcription and translation factors، regulatory
+
+105
+00:07:25,920 --> 00:07:31,520
+proteins، يعني بروتينات منظمة لعمليات التكاثر والـ
+
+106
+00:07:31,520 --> 00:07:31,940
+transcription.
+
+107
+00:07:34,830 --> 00:07:37,230
+Herpes viruses are noted for their ability to 
+
+108
+00:07:37,230 --> 00:07:40,030
+cause latent infection. أعتقد أن كلمة latent
+
+109
+00:07:40,030 --> 00:07:44,410
+infection صارت اسم مرتبط على مين؟ بالـ Herpes virus.
+
+110
+00:07:44,410 --> 00:07:47,430
+اللوحة اللي قدامنا فيها تلات نقاط مهمة طالعة عليها
+
+111
+00:07:47,430 --> 00:07:51,210
+الأصفر على الجانب واحد أن الـ nuclear membrane هذا
+
+112
+00:07:51,210 --> 00:07:56,870
+مميز، تمام؟ اتنين أن ترى nuclear inclusions، أن 
+
+113
+00:07:56,870 --> 00:07:59,730
+الأرض مؤشرة نفسك على طرف وين؟ في النواة. latent
+
+114
+00:07:59,730 --> 00:08:04,250
+infection. هذه تلات صفات مهمة جدًا من هذه اللوحة. الآن
+
+115
+00:08:04,250 --> 00:08:07,030
+الـ latent infection، تقريبًا اللوحة اللي أمامنا هي 
+
+116
+00:08:07,030 --> 00:08:11,910
+ما ذكرت لكم قبل قليل من أنه الفيروس ينجح في البقاء
+
+117
+00:08:11,910 --> 00:08:15,750
+في الـ cytoplasm وبالتالي لا يعبر عنه وبالتالي لن
+
+118
+00:08:15,750 --> 00:08:19,290
+يخرج منه بروتينات على سطح الخلية فلن يتم التعرف
+
+119
+00:08:19,290 --> 00:08:27,430
+عليه. طيب إذا بنقول latent يعني كامن، هل يعود مرة
+
+120
+00:08:27,430 --> 00:08:32,170
+أخرى؟ إيش.. إيش بنسمي العودة؟ reactivation. الـ
+
+121
+00:08:32,170 --> 00:08:36,410
+infection الأولى إيش بنسميها؟ primary infection. و
+
+122
+00:08:36,410 --> 00:08:40,130
+أي subsequent infection بنسميها reactivation، إنه 
+
+123
+00:08:40,130 --> 00:08:46,130
+صار له activation مرة أخرى. غالبًا الـ reactivation
+
+124
+00:08:46,130 --> 00:08:49,830
+تشبه الـ primary infection، يعني طلعت له حب هنا
+
+125
+00:08:49,830 --> 00:08:54,230
+تطلع له مرة ثانية حب هنا. الـ primary infection تشبه
+
+126
+00:08:54,230 --> 00:08:59,250
+قلنا مين؟ مع أن البعض بيقول في المهاجة إنه الـ
+
+127
+00:08:59,250 --> 00:09:01,770
+primary infection is usually more severe أنا بفترض 
+
+128
+00:09:01,770 --> 00:09:07,510
+في الصحيح مع هذا القول لأن ال severity لل herpes
+
+129
+00:09:07,510 --> 00:09:11,990
+virus family غالبا مرتبطة بال degree of immunity
+
+130
+00:09:11,990 --> 00:09:16,130
+فلما دخل الفيروس كيف كان الوضع تبقى المناعة بيكون
+
+131
+00:09:16,130 --> 00:09:21,290
+ال severity تبقى اللي هو ال infection لكن الشاهد 
+
+132
+00:09:21,290 --> 00:09:24,570
+الموضوع أن ال primary infection شبه مين ال
+
+133
+00:09:24,570 --> 00:09:29,440
+reactivation لكن ال Varicella Zoster الـ Chickenpox
+
+134
+00:09:29,440 --> 00:09:33,500
+بيغطي كل الجسم بينما الزوستر الحزام الناري بيغطي
+
+135
+00:09:33,500 --> 00:09:39,140
+جزء من الجسم ايش السبب في الاختلاف يا بنادر؟ السبب
+
+136
+00:09:39,140 --> 00:09:43,240
+في الاختلاف في ال primary infection إنه ما كانش فيه
+
+137
+00:09:43,240 --> 00:09:46,880
+antibodies فبتالي الفيروس استطاع أن يصل إلى جميع
+
+138
+00:09:46,880 --> 00:09:52,210
+أجزاء الجسم بس في ال reactivation هو كان مختبئ في
+
+139
+00:09:52,210 --> 00:09:57,050
+خط اللي هو ال nerve تمام؟ فنفترض أنه طلع أمام
+
+140
+00:09:57,050 --> 00:10:02,150
+العرين تبعه اللي هو ال nerve و سطع أن يحدث عدوى في
+
+141
+00:10:02,150 --> 00:10:07,450
+هذه المنطقة لكن لم يسطع الانتشار إلى باقي الجسم
+
+142
+00:10:07,450 --> 00:10:12,030
+بسبب وجود مين الآن؟ antibodies ال varicella zoster
+
+143
+00:10:12,030 --> 00:10:15,880
+هو فيروس واحد يا جماعة و .. و .. و لما بيكون اسمه
+
+144
+00:10:15,880 --> 00:10:19,900
+Varicella بيكون نفس الفيروس اللي بيكون هو Zoster
+
+145
+00:10:19,900 --> 00:10:22,080
+لأنه ماصارش تغيير في ال genes تبعته أو الـ .. أو الـ
+
+146
+00:10:22,080 --> 00:10:26,240
+antigenet إنما اللي صار تغيير فيه قلنالكوا إنه في
+
+147
+00:10:26,240 --> 00:10:28,580
+حالة ال primary اللي هي الـ .. اللي هي Varicella
+
+148
+00:10:28,580 --> 00:10:34,220
+تكون antibody لاحقا منعت انتشاره لما ظهر بشكل
+
+149
+00:10:34,220 --> 00:10:38,400
+Zoster تمام؟ و في هذه النقطة بدنا نحكيلكوا إياها و
+
+150
+00:10:38,400 --> 00:10:44,160
+نناقشها مع بعض لما بينصابوا الأطفال بالفارسيلا اللي
+
+151
+00:10:44,160 --> 00:10:47,980
+الـ chickenpox بيكون ال disease غالبا mild .. mild
+
+152
+00:10:47,980 --> 00:10:51,520
+يعني خفيف لكن لو لا قدر الله أنتم أنصبتوا فيه
+
+153
+00:10:51,520 --> 00:10:55,080
+الآن وأنتم ماكنتوش مصابين وأنتم صغار بيكون very
+
+154
+00:10:55,080 --> 00:11:01,260
+severe .. severe للكبار و mild للصغار .. هل من
+
+155
+00:11:01,260 --> 00:11:07,540
+تفسير؟ ايش مال المناعة؟ بتكون أني .. وين أفضل
+
+156
+00:11:07,540 --> 00:11:14,170
+بتكون المناعة؟ لأ المناعة بتكون أفضل هون و هم صغار،
+
+157
+00:11:14,170 --> 00:11:19,610
+الجواب صحيح بس التفسير غلط، هي ايه علاقة بالمناعة؟
+
+158
+00:11:19,610 --> 00:11:22,920
+أصلا الـ .. الـ .. الـ physicals اللي
+
+159
+00:11:22,920 --> 00:11:26,060
+نتجت .. هي نتجت من وين هي؟ نتجت من إنه جهاز
+
+160
+00:11:26,060 --> 00:11:29,620
+المناعة has attacked اللي هو الـ .. الـ .. الـ .. الـ
+
+161
+00:11:29,620 --> 00:11:32,320
+virally infected cell فلما منعتي أنا وأنا كبير
+
+162
+00:11:32,320 --> 00:11:37,120
+تكون عالية، آثارها تبعها هيكون عالي، بينما لو كانت
+
+163
+00:11:37,120 --> 00:11:40,940
+منخفضة، هيكون آثارها برضه منخفضة، لذلك كانت mild في
+
+164
+00:11:40,940 --> 00:11:44,520
+الصغار و severe في من في الأكبر، أرجو أن تكون
+
+165
+00:11:44,520 --> 00:11:45,820
+النقطة هذه واضحة
+
+166
+00:11:48,580 --> 00:11:53,540
+بعض التفسير أو جدول هذا يناقش مجموعة من الانتقال
+
+167
+00:11:53,540 --> 00:12:00,480
+المتعلقة بالست فيروسات الموجودة في المجموعة مثلا
+
+168
+00:12:00,480 --> 00:12:05,740
+الـ HSV-1 والـ HSV-2 والفارسيلازوستر هذوله بيشبهوا
+
+169
+00:12:05,740 --> 00:12:09,400
+بعض لدرجة كبيرة فخلينا نحطهم في نصف جدول لحالهم
+
+170
+00:12:10,550 --> 00:12:13,450
+اطلع الـ Root of Transmission على العمود الأخير،
+
+171
+00:12:13,450 --> 00:12:16,810
+هلاقي أنه بيه Respiratory Secretions and Saliva،
+
+172
+00:12:16,810 --> 00:12:21,070
+إنما الثاني Sexual Contact و Perinatal Infection،
+
+173
+00:12:21,070 --> 00:12:25,370
+طبعا الـ Perinatal يعني اللي علاقة بالولادة، الطفل
+
+174
+00:12:25,370 --> 00:12:29,370
+بيولد لأم مصابة بالفيروس بياخد هذا الفيروس معناه
+
+175
+00:12:29,820 --> 00:12:33,100
+رقم تلاتة هي Respiratory Secretions، إذا الأول
+
+176
+00:12:33,100 --> 00:12:37,100
+والثالث Respiratory Secretions، بينما التاني هذا
+
+177
+00:12:37,100 --> 00:12:41,700
+Unique، مميز لأنه Sexually Transmitted بالنسبة لـ
+
+178
+00:12:41,700 --> 00:12:45,680
+Recurrent Infection الأخير، بيكون زوستر، احنا
+
+179
+00:12:45,680 --> 00:12:50,660
+قلنا الأولى Varicella، والثانية زوستر، بينما في
+
+180
+00:12:50,660 --> 00:12:54,980
+الـ Herpes Simplex Type 2 Herpes Genitalis، وكلمة
+
+181
+00:12:54,980 --> 00:12:57,060
+Herpes Genitalis توحي بأن الـ Herpes هذا موجود
+
+182
+00:12:57,060 --> 00:13:01,550
+على جوانب الـ Genital Area الـ Recurrent Infection
+
+183
+00:13:01,550 --> 00:13:04,850
+في الـ Herpes Simplex Type I Herpes Labialis وكلمة
+
+184
+00:13:04,850 --> 00:13:07,590
+Labialis يعني على الشفتين على أي من على أي منطقة
+
+185
+00:13:07,590 --> 00:13:11,650
+من الشفتين Encephalitis يعني اعتلال الدماغ و
+
+186
+00:13:11,650 --> 00:13:16,570
+Keratitis طبعا اللي هي العين الطلاب على الـ الـ
+
+187
+00:13:16,570 --> 00:13:19,950
+primary infection أنا بتخيل أنه كان الأفضل علينا
+
+188
+00:13:19,950 --> 00:13:23,680
+أن نحط اللي كان في الـ current .. في الـ
+
+189
+00:13:23,680 --> 00:13:26,220
+recurrent infection هنطلعها كمان في الـ primary
+
+190
+00:13:26,220 --> 00:13:31,260
+infection ما عدا الأخير الفرسيلة والزاستر لأنه
+
+191
+00:13:31,260 --> 00:13:34,600
+بالفعل ممكن تكون ال primary infection كيراتيتس
+
+192
+00:13:34,600 --> 00:13:40,340
+ممكن تكون herpes labialis من الأساس لكن الشيء
+
+193
+00:13:40,340 --> 00:13:42,680
+الوحيد اللي هم محقين فيه أن يضعوه في ال residual
+
+194
+00:13:42,680 --> 00:13:48,020
+في الـ recurrent هو ال encephalitis وطبعا هنا ممكن
+
+195
+00:13:48,020 --> 00:13:50,990
+يبقى لها كمان يصير فيه complication في ال herpes
+
+196
+00:13:50,990 --> 00:13:54,750
+genitalis يصيب لنا حاجة اسمها meningitis إذا في
+
+197
+00:13:54,750 --> 00:13:58,590
+عندي encephalitis في herpes simplex type 1 herpes
+
+198
+00:13:58,590 --> 00:14:01,450
+simplex type 2 ايش هيكون عنها؟ meningitis و
+
+199
+00:14:01,450 --> 00:14:05,230
+بيسموها aseptic meningitis ايش يعني aseptic
+
+200
+00:14:05,230 --> 00:14:12,340
+meningitis؟ septic يعني فيها بكتيريا، aseptic مافيهاش
+
+201
+00:14:12,340 --> 00:14:16,900
+بكتيريا أو بالأخرى يعني كيف .. كيف نفسرها تطبيقا؟
+
+202
+00:14:16,900 --> 00:14:21,000
+احنا بنقول إنه يطلق كلمة aseptic meningitis أو
+
+203
+00:14:21,000 --> 00:14:25,220
+aseptic arthritis على سبيل المثال على واحد عنده
+
+204
+00:14:25,220 --> 00:14:31,580
+meningitis أو عنده arthritis وخدنا منه سائل CSF أو
+
+205
+00:14:31,580 --> 00:14:36,080
+synovial fluid وعملنا له culture ولم يخرج معنا أي
+
+206
+00:14:36,080 --> 00:14:39,620
+شيء ما قدرناش نعزل أي حاجة في فترة حلقة بسموها ايه؟
+
+207
+00:14:40,600 --> 00:14:45,340
+من meningitis أو aseptic arthritis طبعا لاحظوا أن
+
+208
+00:14:45,340 --> 00:14:50,040
+كلهم بيعملوا لتنسي واحد بيعمل في ال cranial
+
+209
+00:14:50,040 --> 00:14:53,920
+sensory ganglia وفي ال lumbar or sacral sensory
+
+210
+00:14:53,920 --> 00:14:57,340
+ganglia والأخير بيعمل برضه في cranial وthoracic
+
+211
+00:14:57,340 --> 00:15:04,370
+sensory ganglia وطبعا مكان ال common هو المكان
+
+212
+00:15:04,370 --> 00:15:07,530
+الخروج ال recurrence لما أنا بقول في الكرانية
+
+213
+00:15:07,530 --> 00:15:10,290
+لغاية في الكرانية يعني في الـ .. في الرأس مظبوط في
+
+214
+00:15:10,290 --> 00:15:14,650
+الرأس يعني الوجه الوجه يعني الشفتان والعين اللي
+
+215
+00:15:14,650 --> 00:15:17,590
+هنقول عنها ممكن ينصبوا بال recurrent infection
+
+216
+00:15:17,590 --> 00:15:22,170
+بينما في الـ .. الـ .. الـ .. الـ genital herpes الأمر
+
+217
+00:15:22,170 --> 00:15:26,570
+مختلف المكان قريب برضه من ال genital الـ Epstein
+
+218
+00:15:26,570 --> 00:15:30,150
+-Barr Virus والـ Cytomegalovirus والـ Human
+
+219
+00:15:30,150 --> 00:15:33,890
+Herpesvirus Type 8 نفس الفكرة لـ Primary
+
+220
+00:15:33,890 --> 00:15:38,310
+Infections في انحاسمة Infectious Mononucleosis و
+
+221
+00:15:38,310 --> 00:15:41,630
+Congenital Infection اللي هي الـ In-Utero يعني في
+
+222
+00:15:41,630 --> 00:15:50,730
+المرحلة الجنينية و Mononucleosis ال usual اللي
+
+223
+00:15:50,730 --> 00:15:56,060
+تنسي وهو على فكرة هنستخدمه كمان شوية في تصنيف الـ
+
+224
+00:15:56,060 --> 00:16:00,140
+Herpesviruses إلى Alpha, Beta و Gamma، تمام؟ وين
+
+225
+00:16:00,140 --> 00:16:05,280
+الـ tissue اللي بينصاب من هذا الفيروس، فمثلا عندنا
+
+226
+00:16:05,280 --> 00:16:08,280
+الـ B lymphocytes كلمة uncertain, uncertain يعني
+
+227
+00:16:08,280 --> 00:16:13,880
+ماعندناش، خدنا نقول معلومات مؤكدة عن مكان الكمة،
+
+228
+00:16:13,880 --> 00:16:18,780
+لحظة في هذا الـ .. في هذه اللوحة الـ Recurrent
+
+229
+00:16:18,780 --> 00:16:22,580
+Infection None في الـ Epstein-Barr Virus و
+
+230
+00:16:22,580 --> 00:16:26,000
+Asymptomatic Shedding في مين؟ في الـ
+
+231
+00:16:26,000 --> 00:16:28,720
+cytomegalovirus كلمة Asymptomatic Shedding يعني
+
+232
+00:16:28,720 --> 00:16:34,040
+الفيروس بينتج من المريض لكن لا يظهر أي أعراض ولا
+
+233
+00:16:34,040 --> 00:16:35,840
+أي ضرر من هذا الفيروس
+
+234
+00:16:38,490 --> 00:16:43,330
+لو ما فيش أعراض كان ما درسناهوش هنا لكن أنا قلتلكوا
+
+235
+00:16:43,330 --> 00:16:50,070
+قبل قليل أن الـ CMV أحد أهم مسببات ال congenital
+
+236
+00:16:50,070 --> 00:16:54,030
+abnormalities في الولايات المتحدة نسبة كبيرة من
+
+237
+00:16:54,030 --> 00:16:57,990
+الناس قد تصل إلى ثمانين بالمائة عندهم antibody لل
+
+238
+00:16:57,990 --> 00:17:01,930
+cytomegalovirus يعني احنا من مائة شخص هنا ثمانين
+
+239
+00:17:01,930 --> 00:17:08,520
+هنا هيكون CMV فانتشاره واسع لكن لا يوجد لدينا
+
+240
+00:17:08,520 --> 00:17:12,460
+vaccine للـ CMV وهذا بإن نحطه على علامة الاستثناء،
+
+241
+00:17:12,460 --> 00:17:16,460
+مع أنه Zero-Type-1، يعني الحجة اللي كنا ناخدها
+
+242
+00:17:16,460 --> 00:17:20,340
+في القرار إنه فيها أكثر من Zero-Type، لماذا لا
+
+243
+00:17:20,340 --> 00:17:25,640
+يوجد vaccine لهذا الـ Zero-Type؟ بدي أحكي شغل مهم
+
+244
+00:17:25,640 --> 00:17:29,680
+جدا لما نفكر في ال vaccine لازم ال vaccine كله
+
+245
+00:17:29,680 --> 00:17:35,120
+مُردودين مردود صحي تمام؟ ونشوف هل المردود الصحي
+
+246
+00:17:35,120 --> 00:17:41,000
+يعني مستاهل التكاليف اللي احنا ننفقها على هذا ال
+
+247
+00:17:41,000 --> 00:17:45,460
+vaccine ولا لأ؟ وهل هناك بالفعل مخاطر صحية خطيرة
+
+248
+00:17:45,460 --> 00:17:49,940
+كبيرة من هذا الفيروس ولا لأ؟ ليش؟ لأن احنا بنقول
+
+249
+00:17:49,940 --> 00:17:54,800
+الاستثمار في الصحة بيجي برضه من خلال الأولويات مين
+
+250
+00:17:54,800 --> 00:17:58,740
+الأولوية القصوى أن ندور عليه الآن مثلا ال HIV
+
+251
+00:17:58,740 --> 00:18:02,820
+أولوية عن كل الأمراض، الـ tuberculosis أولوية عن
+
+252
+00:18:02,820 --> 00:18:05,960
+الأمراض الأخرى، وبالتالي الموضوع المتعلق به أيضًا 
+
+253
+00:18:05,960 --> 00:18:11,380
+أولويات الـ research وأولويات الصحة العامة بشكل عام
+
+254
+00:18:11,380 --> 00:18:14,560
+الأخير
+
+255
+00:18:14,560 --> 00:18:18,600
+طبعًا أنا قلت لكوا إنه ما بنعرفش يعني أصلًا عنه حاجة
+
+256
+00:18:18,600 --> 00:18:21,120
+إلا أنه بيعمل Kaposi's sarcoma
+
+257
+00:18:25,850 --> 00:18:30,010
+الأولويات هو أن هو الـ virus منتشر بشكل كبير بين
+
+258
+00:18:30,010 --> 00:18:33,650
+الناس، وأن نسبة ضائلة جدًا لمن يعاني من هذا الـ
+
+259
+00:18:33,650 --> 00:18:36,350
+virus نسبة ضائلة، ما انتشر في الولايات، يعني 
+
+260
+00:18:36,350 --> 00:18:40,350
+ما عملولوش؟ لأ، مش قادرين يعملوا له، لأنه زي ما حكيت
+
+261
+00:18:40,350 --> 00:18:44,530
+لكوا الفكرة فيه إنه نسبة كبيرة من الناس مصابين
+
+262
+00:18:44,530 --> 00:18:48,340
+بـ asymptomatic infection يعني زي الـ Toxoplasmosis
+
+263
+00:18:48,340 --> 00:18:51,960
+الـ Toxoplasmosis على سبيل المثال منتشر بنسبة
+
+264
+00:18:51,960 --> 00:18:55,740
+كبيرة جدًا، تمام؟ لكن ما فيش أي أعراض له، ما فيش أي
+
+265
+00:18:55,740 --> 00:19:01,060
+مضار له، فليش هنكلف الدولة أموال طائلة لإنتاج
+
+266
+00:19:01,060 --> 00:19:06,600
+vaccine لمرض ما بيسببش حالات كثيرة من الضرر
+
+267
+00:19:06,600 --> 00:19:10,940
+للبشر؟ وفي كمان نقطة ثانية، الـ immune system تبع الإنسان
+
+268
+00:19:10,940 --> 00:19:14,860
+اللي ما بتحملش vaccine يعني أنا أطعمه لكل
+
+269
+00:19:21,360 --> 00:19:24,720
+لو زاد تركيز الـ antibodies في الـ serum بيظهر علينا 
+
+270
+00:19:24,720 --> 00:19:30,940
+أعراض مرضية بيسموها serum sickness طيب في شغل مهمة
+
+271
+00:19:30,940 --> 00:19:34,400
+في الـ herpes virus family اللي هو الـ rashes وحد
+
+272
+00:19:34,400 --> 00:19:38,200
+مسميها الـ vesicular rashes وكلمة vesicular يعني
+
+273
+00:19:38,200 --> 00:19:43,520
+حويصلات صلاّطية يعني بيكون فيه قشرة رقيقة شفافة من
+
+274
+00:19:43,520 --> 00:19:49,140
+الجلد، وجواها سائل، هذا السائل إما clear أو slightly 
+
+275
+00:19:49,140 --> 00:19:52,680
+turbid clear لأن هو أصلًا clear لأنه بيسموه serous
+
+276
+00:19:52,680 --> 00:19:56,780
+fluid، و slightly turbid لأنه ممكن يكون فيه cell
+
+277
+00:19:56,780 --> 00:20:01,830
+debris، والفيروس نفسه، الفيروس نفسه بيكون موجود في
+
+278
+00:20:01,830 --> 00:20:04,690
+هذه الـ physical، يبقى لما نشوف الحزام الناري مثلًا على
+
+279
+00:20:04,690 --> 00:20:08,870
+اسم المثال اللي هي الـ zoster هذه كويسة واضحة، هي
+
+280
+00:20:08,870 --> 00:20:13,240
+مثلًا في physical واضحة، وهنا في physical واضحة، طبعًا
+
+281
+00:20:13,240 --> 00:20:16,900
+الـ physical ما بتبدأ، physical بتبدأ احمرار زي رش، و
+
+282
+00:20:16,900 --> 00:20:20,240
+بعدين بتتكون الـ physical تبقى على سائل، وممكن
+
+283
+00:20:20,240 --> 00:20:23,660
+تنفجر هذه الـ physical، وبعدين يصير لها crustacea
+
+284
+00:20:23,660 --> 00:20:28,620
+يعني تصير لها قشور، وبعدين تشفى تمامًا، ولا تترك أي
+
+285
+00:20:28,620 --> 00:20:35,960
+آثار إلا إذا قمنا بحكها، وتم التهاب ثانوي
+
+286
+00:20:35,960 --> 00:20:41,080
+ببكتيريا في نفس الموقع، فبالتالي ممكن يصير فينا
+
+287
+00:20:41,080 --> 00:20:46,200
+Scarring أو ندوب ناتج عن هذه الـ Vesicles، بتميز
+
+288
+00:20:46,200 --> 00:20:52,340
+اللي هو الـ ... الـ ... الـ ... الـ ... الفيروسات الثلاثة
+
+289
+00:20:52,340 --> 00:20:55,200
+Herpes simplex type 1 و type 2 و الـ Varicella
+
+290
+00:20:55,200 --> 00:20:58,440
+zoster بإن هما هما التلاتة بشكل اللي هو الـ
+
+291
+00:20:58,440 --> 00:21:01,850
+vesicular rashes طبعًا أنا قلت لكوا الـ vesicular
+
+292
+00:21:01,850 --> 00:21:08,150
+rash بيتمد على الـ disease، إذا كان Varicella zoster
+
+293
+00:21:08,150 --> 00:21:13,390
+في كل الجسم، إذا كان zoster في مكان محدد، إذا كان
+
+294
+00:21:13,390 --> 00:21:17,290
+herpes simplex type 1 غالبًا في منطقة الوجه، إذا
+
+295
+00:21:17,290 --> 00:21:20,030
+كان herpes simplex type 2 اللي هو في منطقة الـ
+
+296
+00:21:20,030 --> 00:21:24,100
+genital area الـ Cytomegalovirus قبل ما ننهي من
+
+297
+00:21:24,100 --> 00:21:28,980
+اللوحة الـ CMV والإبشتين بار فيروس كلهما ما بيعملوا
+
+298
+00:21:28,980 --> 00:21:36,100
+أي Vesicular rash، قلنا كما وعدناكم أن نقسم الـ
+
+299
+00:21:36,100 --> 00:21:39,700
+Herpesvirus family إلى تلات أقسام Alpha Beta
+
+300
+00:21:39,700 --> 00:21:46,050
+و Gamma، والتقسيمة مبنية على مكان تكاثر أو الـ tissue
+
+301
+00:21:46,050 --> 00:21:51,050
+اللي بيستقبل من اللي بيستقبل، اللي هم الفيروسات هذه
+
+302
+00:21:51,050 --> 00:21:54,870
+مثلًا الـ alpha viruses اللي هم أطلعت من نفسهم اللي
+
+303
+00:21:54,870 --> 00:21:58,810
+ذكرتهم قبل قليل، الـ one والـ two والـ varicella
+
+304
+00:21:58,810 --> 00:22:05,870
+zoster virus بيهجموا من الـ epithelial cells، وطبعًا
+
+305
+00:22:05,870 --> 00:22:10,110
+بيكملوا في الـ neurons بينما الـ gamma viruses اللي
+
+306
+00:22:10,110 --> 00:22:15,230
+هي التالتة اللي بتشمل الابستين بار فيروس والـ human
+
+307
+00:22:15,230 --> 00:22:19,710
+herpes type 8 they infect and become latent
+
+308
+00:22:19,710 --> 00:22:23,430
+primarily in lymphoid tissue إذن Epithelial،
+
+309
+00:22:23,430 --> 00:22:25,710
+lymphoid tissue طب اللي في النص اللي هي الـ beta
+
+310
+00:22:25,710 --> 00:22:31,590
+variety of tissues يعني أنسجة مختلفة ومتنوعة
+
+311
+00:22:31,590 --> 00:22:36,510
+وبالتالي يعني ما بنقدرش نحصلها في نسيج محدد منها الـ
+
+312
+00:22:36,510 --> 00:22:41,070
+CMV يعني الـ CMV مثلًا من الأماكن المفضلة له الكلية
+
+313
+00:22:42,450 --> 00:22:47,830
+الـ kidney، الـ kidney، الـ transplant مش هنقول إنه الـ
+
+314
+00:22:47,830 --> 00:22:51,070
+kidney transplant أحد الأشياء اللي ... اللي صارت
+
+315
+00:22:51,070 --> 00:22:56,110
+جزء من نقل الـ CMV فبالتالي يعني لازم يكون فيه
+
+316
+00:22:56,110 --> 00:23:00,550
+فحوصات للـ donors، تمام؟ ليش الآن احنا خايفين؟ جابش
+
+317
+00:23:00,550 --> 00:23:03,150
+اللي احنا كنا بنطمن الناس وبنقول لهم إنه ما بيلزمش
+
+318
+00:23:03,150 --> 00:23:08,480
+fix هناش لإن المرض ضعيف، ما بيسببش خطر، تنسوش لما بننقل
+
+319
+00:23:08,480 --> 00:23:12,040
+احنا transplant لمريض، احنا بنعطيه
+
+320
+00:23:12,040 --> 00:23:15,640
+immunosuppressive agent، احنا بنطبطب له جهاز المناعة
+
+321
+00:23:15,640 --> 00:23:18,740
+يعني الفيروس إذا كان موجود في الكلية الجديدة اللي
+
+322
+00:23:18,740 --> 00:23:24,680
+نقلناها، لو نقلناها حينشط ويتكاثر دون حسيب أو رقيب
+
+323
+00:23:24,680 --> 00:23:30,390
+وبالتالي قد يحدث ضرر لهذا المرض، طبعًا بتاعوا هنا في
+
+324
+00:23:30,390 --> 00:23:33,230
+غزة صار فينا kidney transplantation كل سنة بيجوا
+
+325
+00:23:33,230 --> 00:23:39,830
+مجموعة من أطباء العرب والفلسطينيين في معظمهم من
+
+326
+00:23:39,830 --> 00:23:44,210
+فرنسا ومن بريطانيا، وبيعملوا عمليات زراعة كلى، لكن
+
+327
+00:23:44,210 --> 00:23:51,630
+لحد الآن الفحوصات بتتم خارج البلاد، وفي مساعي حديثة
+
+328
+00:23:51,630 --> 00:23:58,330
+لإنشاء مختبر، وتقريبًا شبه جاهز، ليه؟ إنه يعملوا
+
+329
+00:23:58,330 --> 00:24:00,890
+matching ويعملوا testing لـ ... اللي هو الـ donors
+
+330
+00:24:00,890 --> 00:24:04,430
+ليخلوهم من الأمراض اللي ممكن تنتقل بالـ ... بالـ
+
+331
+00:24:04,430 --> 00:24:10,230
+transplant طيب هذا كمان جدول حلو وجمال هذا الجدول
+
+332
+00:24:10,230 --> 00:24:15,150
+بأنه بيجمع لي بعض الحقائق مع بعضها، طلع لي على الـ
+
+333
+00:24:15,150 --> 00:24:19,570
+antiviral therapy acyclovir ... acyclovir ...
+
+334
+00:24:19,570 --> 00:24:24,040
+acyclovir ... لمين؟ للألفة، للألفة للتلاتة اللي احنا
+
+335
+00:24:24,040 --> 00:24:26,640
+ذكرناهم alpha اللي هم الـ herpes simplex type 1 و
+
+336
+00:24:26,640 --> 00:24:31,020
+type 2 و الـ varicella zoster كمان التلاتة أحد
+
+337
+00:24:31,020 --> 00:24:35,780
+الوسائل المهمة جدًا لتشخيصهم هو الـ cell culture
+
+338
+00:24:35,780 --> 00:24:42,350
+culture بالنسبة للـ fetal or neonatal infection بس
+
+339
+00:24:42,350 --> 00:24:45,990
+الـ herpes simplex type 2 لأنه زي ما حكينالكوا هو
+
+340
+00:24:45,990 --> 00:24:50,490
+ده خارج الطفل، ممكن ياخد من الأم الـ virus لكن type
+
+341
+00:24:50,490 --> 00:24:55,310
+1 و الـ varicella ما فيش خوف من انتقالهم من الأم إلى
+
+342
+00:24:55,310 --> 00:25:01,640
+الجنين بالنسبة لـ الـ giant cell produced طلع واحد
+
+343
+00:25:01,640 --> 00:25:07,400
+اتنين، تلاتة، أربعة، أربع yes، والـ إبشتين بار فيروس و
+
+344
+00:25:07,400 --> 00:25:13,480
+الـ human herpes virus type 8 ما بيعملوش، عارفين ليش؟
+
+345
+00:25:13,480 --> 00:25:17,880
+لأنه التنين specifically بيروحوا على مين؟ على الـ
+
+346
+00:25:17,880 --> 00:25:21,860
+lymphoid tissue، وأصلًا شغلهم سرطانات، دول متخصصين
+
+347
+00:25:21,860 --> 00:25:24,560
+في السرطانات، مش متخصصين في إنهم يعملوا multi
+
+348
+00:25:24,560 --> 00:25:29,570
+nucleated giant cell من المطيف اسم الـ CMV
+
+349
+00:25:29,570 --> 00:25:32,810
+Cytomegalovirus
+
+350
+00:25:32,810 --> 00:25:37,350
+عارفين إيش معناه بالعربي؟ الفيروس المضخم للخلايا
+
+351
+00:25:37,350 --> 00:25:41,370
+اللي احنا بنتكلم عن الـ Giant Cells، وطالع اسم الـ ...
+
+352
+00:25:41,370 --> 00:25:44,670
+الـ ... الـ ... اسم الفيروس أُخذ من شكل الـ ... شكل
+
+353
+00:25:44,670 --> 00:25:47,890
+الـ CPE على الـ Cell Culture، الـ CPE يعني Cytopathic
+
+354
+00:25:47,890 --> 00:25:54,490
+Effect طيب في عندي في الـ culture هنا في عندي حد
+
+355
+00:25:54,490 --> 00:25:58,830
+اسم هيتروفيل شفتها؟ هيتروفيل وفي DNA probes، DNA
+
+356
+00:25:58,830 --> 00:26:02,550
+probes يعني بالـ molecular techniques لكن إيش يعني
+
+357
+00:26:02,550 --> 00:26:07,450
+الهيتروفيل؟ ولمين؟ للإبشتين بار فيروس، الهيتروفيل
+
+358
+00:26:07,450 --> 00:26:14,170
+معناها antibody بيتفاعل مع antigen ليس سبب إنتاجه
+
+359
+00:26:14,170 --> 00:26:17,270
+ناقضته؟
+
+360
+00:26:17,270 --> 00:26:20,930
+antibody المفروض بيتفاعل عن إيه الـ antibody؟ مع
+
+361
+00:26:20,930 --> 00:26:24,530
+الـ antigen اللي سبب خروجه، صح ولا لأ؟ بيكونوا specific
+
+362
+00:26:25,910 --> 00:26:30,790
+الـ gene antibody بتفاعل مع antigens أخرى غير لسببات
+
+363
+00:26:30,790 --> 00:26:34,410
+إنتاجها فسموها heterophil antibody، طبعًا هذا كله
+
+364
+00:26:34,410 --> 00:26:40,050
+منطبق على مجموعة، لكن هذا الفحص أخذ الاسم الوحيد
+
+365
+00:26:40,050 --> 00:26:44,450
+اللي أخذ الاسم، هذا الفحص اسمه heterophil antibody
+
+366
+00:26:44,450 --> 00:26:49,090
+test وبنشخص فيه مين؟ الـ Epstein-Barr virus، طبعًا هو
+
+367
+00:26:49,090 --> 00:26:51,850
+مش فحص دقيق لكن موجود
+
+368
+00:26:58,310 --> 00:27:02,550
+أنا بكون عندي antigens محددة، وبأخد من المريض
+
+369
+00:27:02,550 --> 00:27:06,250
+serum، تمام؟ بكشف بالـ antigens المحددة اللي عندي هذه
+
+370
+00:27:06,250 --> 00:27:10,310
+عن هذا الـ antibody، تمام؟ اللي احنا سميناه هيتروفيل
+
+371
+00:27:10,310 --> 00:27:14,350
+بسبب أنه بيتفاعل مع antigens أخرى غير الـ antigen
+
+372
+00:27:14,350 --> 00:27:17,690
+اللي سبب منها، يعني الـ cross reactivity تبعتها
+
+373
+00:27:17,690 --> 00:27:18,910
+عالية جدًا
+
+374
+00:27:23,720 --> 00:27:27,800
+Tumor Herpes Viruses، احنا ذكرنا قبل قليل إنه في
+
+375
+00:27:27,800 --> 00:27:32,880
+بعض الفيروسات مش متخصصة لتعمل جينز، وإن أنا متخصص 
+
+376
+00:27:32,880 --> 00:27:35,620
+في الـ lymphoid tissue وممكن تعمل سرطانات مثلا
+
+377
+00:27:35,620 --> 00:27:40,320
+الابيشتينبارفيروس is associated with Burkitt's 
+
+378
+00:27:40,320 --> 00:27:43,700
+lymphoma اقرأولي بالله الجملة اللي قولتها قبل 
+
+379
+00:27:43,700 --> 00:27:48,320
+certain herpes viruses are suspected طبعا الجملة
+
+380
+00:27:48,320 --> 00:27:52,460
+هذه بندرسها من كم سنة من سنين وبنقول suspected
+
+381
+00:27:53,590 --> 00:27:57,830
+اللغة العلمية .. اللغة العلمية ليست لغة قطعية يا
+
+382
+00:27:57,830 --> 00:28:01,910
+بنات، لغة مشككة، ويجب أن نتعلم هذه اللغة، يجب أن 
+
+383
+00:28:01,910 --> 00:28:05,330
+نتعلم هذه اللغة، الجملة اللي بعدها على طول بتقول
+
+384
+00:28:12,050 --> 00:28:15,650
+مرتبط يعني لما بنلاقي  percutaneous lymphoma بنهزل منها
+
+385
+00:28:15,650 --> 00:28:21,990
+هذا الفيروس لكن لحد الآن مش واصلين لـ conclusive ل
+
+386
+00:28:21,990 --> 00:28:26,610
+cause and effect أنه نقول ابشتين بار فيروس is the
+
+387
+00:28:26,610 --> 00:28:29,950
+cause of percutaneous lymphoma خايفين يكون في عوامل
+
+388
+00:28:29,950 --> 00:28:34,990
+أخرى إحنا لسه ما تكشفناش فهذا ما قصدته من اللغة
+
+389
+00:28:34,990 --> 00:28:40,470
+العلمية الغير قطعية لأنه إذا قطعنابالـ cause and
+
+390
+00:28:40,470 --> 00:28:44,290
+effect أنا وقفت أي نوع من الـ research بهذا الشأن
+
+391
+00:28:44,290 --> 00:28:48,070
+لأ خلي الناس تبحث و تتأكد من هذا الأمر إذا
+
+392
+00:28:48,070 --> 00:28:53,810
+البركسلينفومة و أنازو فارنجل كارسينوما فيروس واحد
+
+393
+00:28:53,810 --> 00:28:57,410
+اسمه ابشتين بار فيروس الـ human herpes type A
+
+394
+00:28:57,410 --> 00:29:00,470
+يبنالكوا سبب اللي هو كبوس الساركومة اللي لما ندرس
+
+395
+00:29:00,470 --> 00:29:05,160
+الـ aids إن شاء الله هنطلع عليها بشكل جيد Several
+
+396
+00:29:05,160 --> 00:29:09,520
+herpes virus causes cancer in animals كثير من الـ
+
+397
+00:29:09,520 --> 00:29:14,260
+herpes virus بتسبب سرطانات في الحيوانات مثلا 
+
+398
+00:29:14,260 --> 00:29:20,360
+leukemia في القرود تمام و lymphomatosis في الدواجن
+
+399
+00:29:20,360 --> 00:29:25,380
+إذا أيضا الحيوانات بيصير فيها cancer وقد يكون سبب
+
+400
+00:29:25,380 --> 00:29:31,260
+هذا الـ cancer هو الـ الـ الـ الـ الـ herpes كمان مرة
+
+401
+00:29:31,260 --> 00:29:35,060
+أنا عملت محاضرة قبل فترة في يوم دراسي للسرطان في
+
+402
+00:29:35,060 --> 00:29:41,720
+الجامعة وتحدثت فيه عن مسببات السرطان الميكروبية 
+
+403
+00:29:41,720 --> 00:29:48,240
+وحصلنا على معلومات يعني تفيد أن السرطان ممكن
+
+404
+00:29:48,240 --> 00:29:53,230
+ينتقل لحالهالسرطان نفسه ينتقل، إحنا نعرف أن
+
+405
+00:29:53,230 --> 00:29:57,230
+السرطان غير معد، السرطان غير معد، لكن في
+
+406
+00:29:57,230 --> 00:30:01,790
+evidence بدأت تظهر معانا أن هناك بعض أنواع من
+
+407
+00:30:01,790 --> 00:30:04,330
+السرطان في الحيوانات، بعض أنواع من السرطان في
+
+408
+00:30:04,330 --> 00:30:08,310
+الحيوانات قد تنتقل من حيوان إلى حيوان، دون ما
+
+409
+00:30:08,310 --> 00:30:13,210
+انتقال المسبب اللي هو الفيروس، أمام؟فيه كمان حكينا
+
+410
+00:30:13,210 --> 00:30:20,110
+عن سرطان مثلا لحيوان اسمه تزمانيا ديفل شيطان
+
+411
+00:30:20,110 --> 00:30:25,530
+تزمانيا شيطان تزمانيا حيوان صغير هيك يشبه الكلب من
+
+412
+00:30:25,530 --> 00:30:28,710
+الجرابيات تعرفوا الجرابيات اللي هي زي الكنغر اللي
+
+413
+00:30:28,710 --> 00:30:34,610
+بتحط الموضوع تبعها في الكيس هذا الحيوان شبه يعني
+
+414
+00:30:34,610 --> 00:30:38,770
+جبل بينقرض في مناطق في أستراليا في تزمانيا في
+
+415
+00:30:38,770 --> 00:30:43,890
+أستراليا الجوا أن الكلاب لما بتلعب مع بعضها بِعَضّ
+
+416
+00:30:43,890 --> 00:30:50,370
+بتلعب بالعض برضه وللا ففي فيروس بينتقل من المصاب
+
+417
+00:30:50,370 --> 00:30:54,450
+إلى السليم وبيحدث له سرطانات ففي سرطانات في
+
+418
+00:30:54,450 --> 00:30:58,450
+الحيوانات موجودة وموجودة بكثرة وهنا شايفين أن إحنا
+
+419
+00:30:58,450 --> 00:31:04,770
+لوكيميا in monkeys و lymphomatosis in chicken طيب
+
+420
+00:31:04,770 --> 00:31:10,650
+نيجي لـ أول عضوين في المجموعة اللي هما Herpes
+
+421
+00:31:10,650 --> 00:31:15,190
+Simplex Type I و Type II هل هناك فروقات بين الاثنين
+
+422
+00:31:15,190 --> 00:31:21,210
+بشكل بالتركيب؟ لا يوجد إلا بالـ Antigenicity يعني
+
+423
+00:31:21,210 --> 00:31:24,770
+كل واحد فيهم له Antigens مختلفة عن الآخر رقم
+
+424
+00:31:24,770 --> 00:31:29,450
+اثنين الـ location of lesions above the waist و
+
+425
+00:31:29,450 --> 00:31:34,620
+below the waist زي ما ذكرنا في السابق وهذه يمكن
+
+426
+00:31:34,620 --> 00:31:37,860
+اللوحات بتوضح لنا الفروقات الأهم بين الاثنين
+
+427
+00:31:37,860 --> 00:31:43,080
+اطلعوني على الـ Central Nervous System
+
+428
+00:31:43,080 --> 00:31:46,640
+Complications الأولى بيقول عنها Encephalitis
+
+429
+00:31:46,640 --> 00:31:52,960
+والثانية Meningitis الـ Neonates غالبا لا تصاب على
+
+430
+00:31:52,960 --> 00:31:57,020
+الرغم من أن طريقة الانتقال الـ Herpes Simplex Type
+
+431
+00:31:57,020 --> 00:32:02,980
+I للأطفال غالبا بتتم من الكبار عبر التقبيل يعني
+
+432
+00:32:02,980 --> 00:32:06,920
+واحد بيكون مصاب بـ Herpes Simplex Type I وبيقبل
+
+433
+00:32:06,920 --> 00:32:12,940
+الطفل فبينقله الفيروس بينما الـ Herpes Simplex
+
+434
+00:32:12,940 --> 00:32:16,040
+Type II بينتقل عن طريق مرور عبر قناة ولادة
+
+435
+00:32:16,040 --> 00:32:21,960
+الـ I نعم type 1 بسبب keratoconjunctivitis
+
+436
+00:32:21,960 --> 00:32:26,380
+وهي condition صعب يعني الأصل أنه يكون ياخذ عناية
+
+437
+00:32:26,380 --> 00:32:32,180
+خاصة هذا المرض بينما في الـ type 2 مافيش أنه هذه
+
+438
+00:32:32,180 --> 00:32:35,860
+المشكلة الـ mouth طبعا في الفم ممكن يكون
+
+439
+00:32:35,860 --> 00:32:39,560
+gingivostomatitis يعني في الفم فيه rashes لـ type
+
+440
+00:32:39,560 --> 00:32:45,220
+1 لكن type 2 مافيش rashes الجملة الأولى اللي هي
+
+441
+00:32:45,220 --> 00:32:49,880
+قلنا above the waist و below the waist التكرار اللي
+
+442
+00:32:49,880 --> 00:32:54,720
+ما ذكرناه acute gingivostomatitis recurrent herpes
+
+443
+00:32:54,720 --> 00:32:59,800
+labialis اللي إحنا بنسميها تقرحات البرد يعني لما
+
+444
+00:32:59,800 --> 00:33:04,340
+واحد بيكون عنده حُمّى أو بيسموها fever blisters لو
+
+445
+00:33:04,340 --> 00:33:08,140
+يكون عنده حُمّى وبيطلع على الشفة هذا الخارجي الشفة
+
+446
+00:33:08,140 --> 00:33:12,120
+الخارجي هذا إذا حد طلع له يعرف أن هو عنده herpes
+
+447
+00:33:12,120 --> 00:33:18,080
+simplex type 1 وهذا سيبقى معه إلى الأبد يعني هيموت
+
+448
+00:33:18,080 --> 00:33:23,080
+معك تمام؟ هذا صديق اللي مشبر .. إحنا مشبرين عليه
+
+449
+00:33:23,080 --> 00:33:28,920
+ليه مشبرين عليه؟ لأن حتى لما بيخف بيروح هو بيروحش
+
+450
+00:33:30,230 --> 00:33:36,510
+مختفي كامن وإحنا في الطب ليس لدينا أي تقنيات أو
+
+451
+00:33:36,510 --> 00:33:43,670
+أي مهارات في بنعالج بنمنع حدوث لكن لا نستطيع إخراج
+
+452
+00:33:43,670 --> 00:33:49,250
+حالة الكمون من جسم الإنسان إذا فيروس كامن ليس
+
+453
+00:33:49,250 --> 00:33:53,230
+لدينا في الوقت الراهن أي إمكانية لإخراج هذا أو
+
+454
+00:33:53,230 --> 00:33:57,890
+التخلص من هذا الكمون keratoconjunctivitis and
+
+455
+00:33:57,890 --> 00:34:01,630
+encephalitis الـ Herpes Simplex Type 2 تلاتة
+
+456
+00:34:01,630 --> 00:34:05,710
+مشهورين فيهم Genital Herpes و Neonatal Herpes
+
+457
+00:34:05,710 --> 00:34:09,550
+و Aseptic Meningitis ككمبليكيشن اللي ذكرناها قبل
+
+458
+00:34:09,550 --> 00:34:18,010
+قليل كمان
+
+459
+00:34:18,010 --> 00:34:22,170
+شغل بتساعدنا في التفريق بينهم حاجة مع Restriction
+
+460
+00:34:22,170 --> 00:34:26,960
+Endonucleases إيش يعني Endonucleases؟ اللي هي
+
+461
+00:34:26,960 --> 00:34:31,340
+restriction enzymes اللي بتقطع الـ DNA مظبوط وإنتوا
+
+462
+00:34:31,340 --> 00:34:35,400
+عارفين أن كل restriction enzyme له site محدد،
+
+463
+00:34:35,400 --> 00:34:41,820
+sequence محدد بيقطع عنده تخيلوا جبنا أربع دفعات من
+
+464
+00:34:41,820 --> 00:34:45,760
+نفس النوع من البكتيريا أربع دفعات من نفس النوع من
+
+465
+00:34:45,760 --> 00:34:48,840
+البكتيريا أخدنا الـ genome تبعها، أخدنا الـ genome
+
+466
+00:34:48,840 --> 00:34:53,650
+تبعها، أخدنا الـ genome تبعها وحطينا عليهم نفس
+
+467
+00:34:53,650 --> 00:34:56,990
+الأنواع ونفس العدد من مين من الـ restriction enzyme
+
+468
+00:34:56,990 --> 00:35:02,390
+ودخلناهم gel electrophoresis هل ترى القطع تبعاتهم
+
+469
+00:35:02,390 --> 00:35:06,030
+هتختلف الـ pattern النمط تبعهم هيختلف ولا هيكون نفس
+
+470
+00:35:06,030 --> 00:35:10,010
+النمط هيكون نفس النمط لأن أنا استخدمت نفس المادة
+
+471
+00:35:10,010 --> 00:35:14,570
+الوراثية ونفس الـ restriction enzyme حالة بسميها
+
+472
+00:35:14,570 --> 00:35:17,810
+finger printing بس مش finger printing بصمات أصابع
+
+473
+00:35:17,810 --> 00:35:23,320
+بسميها DNA finger printing نستطيع من خلال
+
+474
+00:35:23,320 --> 00:35:26,860
+Restriction in the Nucleus أيضا نميز بين Herpes
+
+475
+00:35:26,860 --> 00:35:31,220
+Type I و Herpes Type II وكمان ذكرنا في اللوحات
+
+476
+00:35:31,220 --> 00:35:34,900
+السابقة أنه ممكن نميزهم من خلال الـ Antigenicity
+
+477
+00:35:34,900 --> 00:35:40,960
+باستخدام Monoclonal Antibodies على الرغم من أن
+
+478
+00:35:40,960 --> 00:35:45,280
+المعلومة المفروضة أنها تكون مهمة إلا أن قدرة
+
+479
+00:35:45,280 --> 00:35:48,620
+الميكروب على الكمون تجعل أن هذه المعلومة غير مهمة
+
+480
+00:35:48,620 --> 00:35:53,320
+أن humans are the only natural host for اللي هو
+
+481
+00:35:53,320 --> 00:35:57,180
+الـ herpes simplex type 1 and type 2 لو في
+
+482
+00:35:57,180 --> 00:36:01,260
+البكتيريا إذا عزلنا البناء أدمين المصابين
+
+483
+00:36:01,260 --> 00:36:08,460
+بالبكتيريا بنكون خلصنا على المرض من كوكب الأرض في
+
+484
+00:36:08,460 --> 00:36:11,540
+الفيروسات اللي بتعمل latency أنا بعالجهم بس بقدر
+
+485
+00:36:11,540 --> 00:36:16,120
+أخلص الـ latency بقدرش وهنشوف في الـ CMV أنه قلتلكوا
+
+486
+00:36:16,120 --> 00:36:18,920
+أكثر من مرة في الـ CMV في عندي حاجة اسمها
+
+487
+00:36:18,920 --> 00:36:24,240
+asymptomatic shedding يعني الشخص ليس لديه أي أعراض
+
+488
+00:36:24,240 --> 00:36:29,340
+لكن ماشي وبينشر من الـ CMV إحنا كنا زمان نقول
+
+489
+00:36:29,340 --> 00:36:32,300
+البكتيريا أنجح المخلوقات، مين أنجح المخلوقات؟
+
+490
+00:36:32,300 --> 00:36:36,220
+الفيروسات، مين أكثر المخلوقات عالمية على كوكب
+
+491
+00:36:36,220 --> 00:36:40,240
+الأرض؟ الفيروسات، هم هم تخيلوا، وبيقولوا إنها
+
+492
+00:36:40,240 --> 00:36:42,880
+الأدنى في السلسلة، مين الأدنى في السلسلة؟ طلعنا
+
+493
+00:36:42,880 --> 00:36:45,860
+إحنا، قولنا لا، إحنا أُجَل .. أُجَل من الصراصير اللي
+
+494
+00:36:45,860 --> 00:36:50,730
+موجودة في الـ ..إنتوا عارفين في مقولة على موضوع
+
+495
+00:36:50,730 --> 00:36:54,990
+الحشرات، الحشرات من أنجح المخلوقات أيضا في البقاء،
+
+496
+00:36:54,990 --> 00:36:59,410
+وأحد العلماء بيقول إن أردت أن يعني تبقى حيا لفترة
+
+497
+00:36:59,410 --> 00:37:02,830
+طويلة فاختبئ داخل حشرة، اختبئ داخل حشرة، دلالة على
+
+498
+00:37:02,830 --> 00:37:06,430
+أن الحشرات لديها المقدرة إنتوا بتشوفوها في البيوت
+
+499
+00:37:07,270 --> 00:37:10,390
+النظيفة والمرتبة وكل إشي كراميكا وجزاز وكده و
+
+500
+00:37:10,390 --> 00:37:14,390
+مالك إلا اللي لاجي حشرات جاية عندها في البيت فهي 
+
+501
+00:37:14,390 --> 00:37:18,930
+عندها المقدر عليها تعيش بشكل يعني ملفت للنظر
+
+502
+00:37:18,930 --> 00:37:22,570
+الصحيحة
+
+503
+00:37:22,570 --> 00:37:26,710
+HSV-1 is transmitted primarily in saliva عن طريق 
+504
+00:37:26,710 --> 00:37:31,770
+اللعاب، وهناك التقبيل أحد الطرق، بينما ال
+
+505
+00:37:31,770 --> 00:37:34,510
+herpes simplex type 2 بينتقل mainly عن طريق ال
+506
+00:37:34,510 --> 00:37:35,770
+sexual contact
+
+507
+00:37:38,910 --> 00:37:43,690
+ولهذا السبب بنلاقي إنه العُراض تبع الـ herpes 
+
+508
+00:37:43,690 --> 00:37:48,470
+simplex type 1 في الـ face بينما الـ herpes simplex
+
+509
+00:37:48,470 --> 00:37:51,470
+type 2 بتكون بُلوغ أنها دوام في الـ genital area
+
+510
+00:37:51,470 --> 00:37:55,530
+الحين
+
+511
+00:37:55,530 --> 00:37:59,350
+إحنا مفترضين إن أنا في عندي vesicle صح؟ الـ
+
+512
+00:37:59,350 --> 00:38:04,310
+vesicle هادي مغطية لسه السائل اللي جواها ما طلعش
+
+513
+00:38:04,310 --> 00:38:10,600
+بره تمام؟ لو انفجرت، جزء كبير من الفيروس اللي موجود
+
+514
+00:38:10,600 --> 00:38:14,920
+جوا هيصير موجود في هذا السائل، لو هذا السائل لمس
+
+515
+00:38:14,920 --> 00:38:19,420
+أي شخص آخر أكيد هيكون infectious، هذا أمر مفروض
+
+516
+00:38:19,420 --> 00:38:25,860
+منه، المشكلة وين؟ إذا ما فيش physicals  نُهل ترى هل
+
+517
+00:38:25,860 --> 00:38:28,820
+الإنسان بينتج الـ virus ولا بينتج الـ virus؟
+
+518
+00:38:31,060 --> 00:38:36,080
+في معظم حالات الـ syphilis الجنسي أو اللاجنسي اللي
+
+519
+00:38:36,080 --> 00:38:39,320
+هو الـ herpes syphilis type 1، ورد أن الإنسان اللي
+
+520
+00:38:39,320 --> 00:38:43,860
+ما عندوش عرض كان شد، شد يعني بينتج أو بيفرز أو
+
+521
+00:38:43,860 --> 00:38:48,100
+بيرمي بيروسات، وإن كان عادي قليل، لكن في الحالتين
+
+522
+00:38:48,100 --> 00:38:51,020
+ممكن يكون معدي، في الحالتين ممكن يكون معدي، يعني
+
+523
+00:38:51,020 --> 00:38:54,180
+في حالة الـ active وفي حالة الـ non-active
+
+524
+00:38:57,680 --> 00:39:02,040
+الـ HSV2 طبعًا في أوروبا ودولة المتحدة ازداد في
+
+525
+00:39:02,040 --> 00:39:05,960
+السنوات الأخيرة، وأي مرض جنسي أصلًا بيزداد، وخليني
+
+526
+00:39:05,960 --> 00:39:11,640
+أنا أقف يعني لحظة عن الأمراض الجنسية، الأمراض
+
+527
+00:39:11,640 --> 00:39:15,500
+الجنسية المنتقلة عن طريق الجنس منتشرة بشكل كبير في
+
+528
+00:39:15,500 --> 00:39:19,900
+أوروبا وأمريكا وفي كل العالم اللاديني تمام؟
+
+529
+00:39:19,900 --> 00:39:23,420
+والغربي، حتى في البلدان اللي فيها انحلال خلقي من
+
+530
+00:39:23,420 --> 00:39:27,380
+البلدان الإسلامية أيضًا الأمراض الجنسية منتشرة فيها
+
+531
+00:39:27,380 --> 00:39:33,080
+بكثرة، والجميع يعلم أن ممارسة الجنس خارج علاقة
+
+532
+00:39:33,080 --> 00:39:38,020
+زوجية طبيعية هي السبب الرئيسي إلا إنهم شيطانهم
+
+533
+00:39:38,020 --> 00:39:42,440
+يخبرهم بأنهم ينتقلوا، عبارات لطيفة مثل practice
+
+534
+00:39:42,440 --> 00:39:46,350
+safe sex يعني استخدم الواقي مثلًا للممارسة الجنسية
+
+535
+00:39:46,350 --> 00:39:51,610
+ولكن لازم تنتشر عن الممارسة الجنسية للأسف هذا هو
+
+536
+00:39:51,610 --> 00:39:56,850
+الموجه الرئيسي لازدياد حالات الأمراض الجنسية، ما
+
+537
+00:39:56,850 --> 00:40:02,210
+زالت الجنورية مسيطرة، ما زالت الكلاميديا مسيطرة، الـ
+
+538
+00:40:02,210 --> 00:40:07,090
+HIV مسيطرة، الـ syphilis مسيطرة، وإن الـ herpes
+
+539
+00:40:07,090 --> 00:40:13,760
+genitalis أيضًا مسيطرة، فنسبة كبيرة من الناس في
+
+540
+00:40:13,760 --> 00:40:18,560
+أوروبا أو أمريكا أو العالم اللاديني غالبًا مصابين
+
+541
+00:40:18,560 --> 00:40:23,700
+بأمراض جنسية كثيرة، فلما نسمع إنه في ازدياد في
+
+542
+00:40:23,700 --> 00:40:30,780
+حالات الأمراض الجنسية أمر غير مستغرب، 80% of
+
+543
+00:40:30,780 --> 00:40:35,260
+people في الولايات المتحدة are infected with HSV-1
+
+544
+00:40:35,260 --> 00:40:43,330
+HSV-1 مش مرض جنسي، لكن 80% منهم مصابين فيه، الآن 40%
+
+545
+00:40:43,330 --> 00:40:47,590
+من الناس المصابين من 80% بيصير إنهم reactivation at
+
+546
+00:40:47,590 --> 00:40:51,110
+least once in their lifetime، كلمة reactivation أنا 
+
+547
+00:40:51,110 --> 00:40:52,990
+أعتقد إنكم شفتوا إيش هنا reactivation في الـ
+
+548
+00:40:52,990 --> 00:40:56,730
+herpes simplex type ولا حاجة بليستر صح؟ اللي هي
+
+549
+00:40:56,730 --> 00:41:00,230
+الحب اللي طلعتناها أو الحم اللي طلعتناها وانتهى
+
+550
+00:41:00,230 --> 00:41:05,010
+الموضوع، لكن في الجنسي قد يصل إلى جنة meningitis
+
+551
+00:41:05,010 --> 00:41:07,570
+وخاصة by repeated infection
+
+552
+00:41:09,820 --> 00:41:12,220
+طبعًا حالات الـ .. الـ .. الـ .. الـ .. الـ herpes
+
+553
+00:41:12,220 --> 00:41:16,160
+simplex type 1 غالبًا تحدث في سن مبكرة عند الأطفال
+
+554
+00:41:16,160 --> 00:41:19,440
+بينما الـ herpes simplex type 2 لأنه بينتقل عن طريق
+
+555
+00:41:19,440 --> 00:41:22,140
+الـ genes فبيكون عند اللي هو مرحلة البلوغ
+
+556
+00:41:25,740 --> 00:41:29,560
+تقريبًا يمكن اللي لو أحد حكيناها، لكن اللي تنسي ..
+
+557
+00:41:29,560 --> 00:41:32,860
+اللي تنسي .. مين اللي بيخل .. بيعمله triggering،
+
+558
+00:41:32,860 --> 00:41:38,600
+triggering يعني يصحيه من النوم، هو الآن كامن ..
+
+559
+00:41:38,600 --> 00:41:45,160
+كامن وغير نشط ولا يعبر عن نفسه، ما هي الأحوال التي
+
+560
+00:41:45,160 --> 00:41:50,580
+يمكن لها أن تستثير هذا الفيروس للـ reactivation
+
+561
+00:41:50,580 --> 00:41:55,880
+واحد Sunlight، اتعرض للشمس الحارقة لفترة طويلة
+
+562
+00:41:55,880 --> 00:41:59,460
+اثنين، وهذا على فكرة بيؤدي للجفاف، وحتى لو ما
+
+563
+00:41:59,460 --> 00:42:04,080
+اتعرضناش للشمس الحارقة وصار فيه جفاف تمام؟ يعني
+
+564
+00:42:04,080 --> 00:42:08,340
+مثلًا في مرحلة الصيام في رمضان وكان الإنسان نشط
+
+565
+00:42:08,340 --> 00:42:13,520
+لفترة طويلة وقطش كثير جف الحلق طبعه وشفايفه قد
+
+566
+00:42:13,520 --> 00:42:17,840
+يظهر ocelo activation تمام؟ hormonal changes
+
+567
+00:42:17,840 --> 00:42:22,740
+تغيرات هرمونية في فترة الدورة الشهرية أو في انتقال
+
+568
+00:42:22,740 --> 00:42:29,460
+من سن الطفولة إلى سن البلوغ أو سن اليأس يعني أي
+
+569
+00:42:29,460 --> 00:42:33,620
+hormonal changes ممكن تؤدي لهذا الموضوع، trauma خطأ
+
+570
+00:42:36,420 --> 00:42:40,780
+Stress، توتر، انتحان، quiz، الهاتف ليس لديه 
+
+571
+00:42:40,780 --> 00:42:48,500
+إنترنت، Unfever، الحُمّة أيضًا عامل مهم جدًا من
+
+572
+00:42:48,500 --> 00:42:51,860
+العوامل اللي ممكن تعمل triggering للـ reactivation
+
+573
+00:42:53,930 --> 00:43:00,550
+الـ immunity غالبًا بيسموها type specific يعني إذا
+
+574
+00:43:00,550 --> 00:43:04,370
+أخذنا فيروس واحد هشيل إنها immunity لمين؟ للفيروس
+
+575
+00:43:04,370 --> 00:43:09,770
+واحد، إذا أخذنا اثنين هشيل إنها للاثنين، لكن يوجد
+
+576
+00:43:09,770 --> 00:43:15,420
+somehow cross protected يعني خدنا نقول جزء من الـ
+
+577
+00:43:15,420 --> 00:43:18,740
+cross-protectivity يعني إذا انصاب واحد بيحميه
+
+578
+00:43:18,740 --> 00:43:24,240
+جزئيًا ولكن ليس كليًا من النوع الثاني، سميناها some
+
+579
+00:43:24,240 --> 00:43:29,160
+cross-protection exist، الـ Cell-mediated immunity
+
+580
+00:43:29,160 --> 00:43:34,180
+هي الأهم على الإطلاق في حال الـ Herpes virus سميلي
+
+581
+00:43:34,180 --> 00:43:37,560
+وكيف عرفنا إنها الأهم على الإطلاق؟ لما عملنا لها
+
+582
+00:43:37,560 --> 00:43:40,840
+suppression للـ Cell-mediated immunity صار فينا
+
+583
+00:43:40,840 --> 00:43:44,960
+severe cases of Herpes Simplex type 1 and type 2
+
+584
+00:43:44,960 --> 00:43:48,140
+المرة الجاية إن شاء الله بنكمل مع هذه الفيروسات
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e31d77d2a5d95b4365bf45e2d7ea870d34d23ab4
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 4513, "start": 21.13, "end": 45.13, "text": "فبسم الله الرحمن الرحيم الحمد لله رب العالمين اليوم ان شاء الله هو ال clinical virology و clinical virology يعني نتكلم عن الفيروسات و نتكلم عن ال diseases و عن ال mechanism by which they produce the disease و عن ال treatment و عن ال prevention و ايضا عن ال diagnosis يعني هي عبارة عن diagnostic virology او medical virology", "tokens": [5172, 3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 21542, 2304, 3215, 24976, 3224, 12602, 3555, 18863, 45340, 9957, 45595, 20498, 16472, 13412, 16606, 21984, 31439, 2423, 9115, 1932, 20978, 88, 4032, 9115, 1932, 20978, 88, 37495, 22653, 8717, 2655, 4117, 19528, 18871, 27188, 13546, 41779, 9307, 4032, 8717, 2655, 4117, 19528, 18871, 2423, 11044, 4032, 18871, 2423, 7513, 538, 597, 436, 5258, 264, 4752, 4032, 18871, 2423, 5032, 4032, 18871, 2423, 14630, 4032, 1975, 1829, 11242, 995, 18871, 2423, 15217, 37495, 22653, 39896, 6225, 3555, 9640, 3660, 18871, 27897, 1932, 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الفيروس كيف كان الوضع تبقى المناعة بيكون ال severity تبقى اللي هو ال infection لكن الشهدة الموضوع ان ال primary infection شبه مين ال reactivation لكن ال Varicella Zoster", "tokens": [6027, 39184, 6194, 11764, 307, 2673, 544, 8922, 41850, 4724, 5172, 2655, 2288, 8978, 31767, 5016, 1829, 5016, 20449, 23758, 25062, 12610, 5296, 33456, 2423, 35179, 24976, 720, 5190, 5752, 1605, 32771, 6027, 3555, 995, 3714, 43500, 3555, 9566, 3660, 20666, 4314, 295, 22701, 6156, 1211, 15042, 11778, 9778, 1211, 27188, 13546, 41779, 9122, 33911, 25961, 2423, 2407, 11242, 3615, 6055, 3555, 4587, 7578, 9673, 8315, 27884, 4724, 1829, 30544, 2423, 35179, 6055, 3555, 4587, 7578, 13672, 1829, 31439, 2423, 11764, 44381, 25124, 3224, 3215, 3660, 9673, 2407, 11242, 45367, 16472, 2423, 6194, 11764, 13412, 3555, 3224, 3714, 9957, 2423, 4515, 592, 399, 44381, 2423, 14662, 299, 9885, 1176, 7096], "avg_logprob": -0.22297296706620637, "compression_ratio": 1.6859205776173285, "no_speech_prob": 5.960464477539063e-08, 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antibodies ال varicella zoster هو فيروس واحد يا جماعة", "tokens": [41185, 16490, 9566, 13672, 1829, 31439, 2423, 16355, 46811, 10943, 22807, 6156, 1863, 5172, 2655, 43042, 14739, 3224, 23032, 1211, 3615, 5551, 2304, 10943, 18863, 2288, 9957, 6055, 3555, 3615, 3224, 13672, 1829, 31439, 2423, 16355, 4032, 8608, 9566, 3615, 14739, 7251, 24401, 12984, 6225, 3215, 2407, 7578, 8978, 29538, 9673, 1863, 9566, 28671, 44381, 32767, 7251, 3794, 9566, 3615, 2423, 7649, 2655, 8592, 9640, 30731, 4724, 995, 38436, 25724, 38251, 4724, 35457, 3555, 49610, 23328, 3714, 9957, 6024, 48506, 22807, 28356, 2423, 1374, 573, 3505, 710, 7096, 31439, 8978, 32887, 3794, 36764, 24401, 35186, 10874, 15042, 27884], "avg_logprob": -0.18166035172915218, "compression_ratio": 1.5921052631578947, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 592.01, "end": 592.21, "word": "في", "probability": 0.60400390625}, {"start": 592.21, "end": 592.75, "word": " خط", "probability": 0.983154296875}, {"start": 592.75, 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يعني مستاهل التكاريف اللي احنا ننفقها على هذا ال vaccine ولا لأ؟ وهل هناك بالفعل مدار صحية خطيرة كبيرة من هذا الفيروس ولا لأ؟ ليش؟ لأن احنا بنقول الاستثمار في الصحة بيجي برضه من خلال الأولويات", "tokens": [3555, 16254, 1975, 5016, 4117, 1829, 13412, 17082, 1211, 3714, 16095, 10874, 28259, 5296, 15042, 8717, 5172, 37983, 8978, 2423, 7007, 5296, 31377, 2304, 2423, 7007, 28242, 3224, 3714, 2288, 3215, 23328, 9957, 3714, 2288, 3215, 23328, 20328, 5016, 1829, 46811, 10943, 22807, 4032, 1863, 8592, 38688, 8032, 1211, 9673, 2288, 3215, 23328, 31767, 5016, 1829, 37495, 22653, 3714, 14851, 40294, 1211, 16712, 4117, 9640, 33911, 13672, 1829, 1975, 5016, 8315, 8717, 1863, 5172, 4587, 11296, 15844, 23758, 2423, 7007, 49429, 5296, 10721, 22807, 37037, 1211, 34105, 4117, 20666, 5172, 30241, 3714, 3215, 9640, 20328, 5016, 10632, 16490, 9566, 48923, 9122, 3555, 48923, 9154, 23758, 27188, 13546, 41779, 49429, 5296, 10721, 22807, 32239, 8592, 22807, 5296, 33456, 1975, 5016, 8315, 44945, 39648, 42963, 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2288, 3794, 36764, 24401, 8032, 8592, 26895, 14739, 11296, 22701, 5296, 2304, 9957, 22807, 5296, 5172, 13546, 3794, 36764, 24401, 11933, 15730, 5551, 9778, 3215, 8315, 1975, 2655, 1863, 9957, 8032, 8592, 26895, 14739, 11296, 5296, 9307, 1863, 9957, 44381, 7251, 29245, 3215, 6063, 3278, 10594, 37495, 22653, 16490, 3215, 8315, 8717, 39648], "avg_logprob": -0.19243420346787102, "compression_ratio": 1.6264367816091954, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2573.93, "end": 2574.85, "word": "ال", "probability": 0.94384765625}, {"start": 2574.85, "end": 2575.49, "word": " immunity", "probability": 0.66455078125}, {"start": 2575.49, "end": 2576.43, "word": " غالبا", "probability": 0.9759521484375}, {"start": 2576.43, "end": 2577.63, "word": " بيسموها", "probability": 0.9419921875}, {"start": 2577.63, "end": 2578.15, "word": " type", "probability": 0.9052734375}, {"start": 2578.15, "end": 2578.93, "word": " specific", "probability": 0.931640625}, {"start": 2578.93, "end": 2579.81, "word": " يعني", "probability": 0.8359375}, {"start": 2579.81, "end": 2580.55, "word": " إذا", "probability": 0.757080078125}, {"start": 2580.55, "end": 2581.31, "word": " أخدنا", "probability": 0.9599609375}, {"start": 2581.31, "end": 2581.65, "word": " فيرس", "probability": 0.6464029947916666}, {"start": 2581.65, "end": 2582.17, "word": " واحد", "probability": 0.983642578125}, {"start": 2582.17, "end": 2582.73, "word": " هشيل", "probability": 0.5454305013020834}, {"start": 2582.73, "end": 2582.93, "word": " أنها", "probability": 0.717529296875}, {"start": 2582.93, "end": 2583.17, "word": " immunity", "probability": 0.9306640625}, {"start": 2583.17, "end": 2583.93, "word": " لمين؟", "probability": 0.69830322265625}, {"start": 2583.93, "end": 2584.37, "word": " لفيرس", "probability": 0.8330078125}, {"start": 2584.37, "end": 2584.73, "word": " واحد", "probability": 0.99267578125}, {"start": 2584.73, "end": 2585.49, "word": " إذا", "probability": 0.800537109375}, {"start": 2585.49, "end": 2585.81, "word": " أخدنا", "probability": 0.9532470703125}, {"start": 2585.81, "end": 2586.31, "word": " اتنين", "probability": 0.9215087890625}, {"start": 2586.31, "end": 2586.69, "word": " هشيل", "probability": 0.9404296875}, {"start": 2586.69, "end": 2587.01, "word": " أنها", "probability": 0.887451171875}, {"start": 2587.01, "end": 2587.63, "word": " لاتنين", "probability": 0.8603515625}, {"start": 2587.63, "end": 2588.67, "word": " لكن", "probability": 0.8759765625}, {"start": 2588.67, "end": 2589.77, "word": " يوجد", "probability": 0.9814453125}, {"start": 2589.77, "end": 2591.09, "word": " somehow", "probability": 0.90869140625}, {"start": 2591.09, "end": 2592.43, "word": " cross", "probability": 0.91552734375}, {"start": 2592.43, "end": 2593.09, "word": " protected", "probability": 0.2998046875}, {"start": 2593.09, "end": 2593.77, "word": " يعني", "probability": 0.908935546875}, {"start": 2593.77, "end": 2594.07, "word": " خدنا", "probability": 0.9469401041666666}, {"start": 2594.07, "end": 2594.37, "word": " نقول", "probability": 0.993896484375}], "temperature": 1.0}, {"id": 109, "seek": 260594, "start": 2594.72, "end": 2605.94, "text": "جزء من ال cross-protectivity يعني إذا انصاب واحد بيحميه جزئيا ولكن ليس كليا من النوع التانية سمناها some cross-protection exist", "tokens": [7435, 11622, 38207, 9154, 2423, 3278, 12, 33629, 557, 4253, 37495, 22653, 11933, 15730, 16472, 9381, 16758, 36764, 24401, 4724, 1829, 35571, 1829, 3224, 10874, 11622, 19986, 25528, 35525, 19452, 32239, 3794, 28242, 25528, 9154, 28239, 45367, 16712, 7649, 10632, 8608, 2304, 8315, 11296, 512, 3278, 12, 33629, 10183, 2514], "avg_logprob": -0.24877450629776598, "compression_ratio": 1.3241379310344827, "no_speech_prob": 0.0, "words": [{"start": 2594.72, "end": 2595.16, "word": "جزء", "probability": 0.69268798828125}, {"start": 2595.16, "end": 2595.32, "word": " من", "probability": 0.98974609375}, {"start": 2595.32, "end": 2595.42, "word": " ال", "probability": 0.56591796875}, {"start": 2595.42, "end": 2595.64, "word": " cross", "probability": 0.423583984375}, {"start": 2595.64, "end": 2596.3, "word": "-protectivity", "probability": 0.7662353515625}, {"start": 2596.3, "end": 2596.54, "word": " يعني", "probability": 0.751953125}, {"start": 2596.54, "end": 2596.84, "word": " إذا", "probability": 0.92529296875}, {"start": 2596.84, "end": 2597.24, "word": " انصاب", "probability": 0.7196451822916666}, {"start": 2597.24, "end": 2597.78, "word": " واحد", "probability": 0.9248046875}, {"start": 2597.78, "end": 2598.74, "word": " بيحميه", "probability": 0.94912109375}, {"start": 2598.74, "end": 2599.48, "word": " جزئيا", "probability": 0.9022216796875}, {"start": 2599.48, "end": 2600.42, "word": " ولكن", "probability": 0.75341796875}, {"start": 2600.42, "end": 2600.86, "word": " ليس", "probability": 0.986572265625}, {"start": 2600.86, "end": 2601.66, "word": " كليا", "probability": 0.6796875}, {"start": 2601.66, "end": 2601.92, "word": " من", "probability": 0.9873046875}, {"start": 2601.92, "end": 2602.44, "word": " النوع", "probability": 0.978759765625}, {"start": 2602.44, "end": 2602.86, "word": " التانية", "probability": 0.9436848958333334}, {"start": 2602.86, "end": 2603.48, "word": " سمناها", "probability": 0.7760009765625}, {"start": 2603.48, "end": 2604.24, "word": " some", "probability": 0.7529296875}, {"start": 2604.24, "end": 2604.74, "word": " cross", "probability": 0.91796875}, {"start": 2604.74, "end": 2605.4, "word": "-protection", "probability": 0.7470703125}, {"start": 2605.4, "end": 2605.94, "word": " exist", "probability": 0.58447265625}], "temperature": 1.0}, {"id": 110, "seek": 262814, "start": 2607.14, "end": 2628.14, "text": "الـ Cell-mediated immunity هي الأهم على الإطلاق في حال الـ Herpes virus سميلي و كيف عرفنا إنها الأهم على الإطلاق؟ لما عملنا لها suppression للـ Cell-mediated immunity صار فينا severe cases of Herpes Simplex type 1 and type 2 المرة الجاية إن شاء الله بنكمل مع هذه الفيروسات", "tokens": [6027, 39184, 28859, 12, 3130, 770, 22701, 39896, 16247, 16095, 15844, 33688, 9566, 15040, 4587, 8978, 11331, 6027, 2423, 39184, 3204, 5190, 5752, 8608, 2304, 1829, 20292, 4032, 9122, 33911, 6225, 28480, 8315, 36145, 11296, 16247, 16095, 15844, 33688, 9566, 15040, 4587, 22807, 5296, 15042, 6225, 42213, 8315, 5296, 11296, 36807, 24976, 39184, 28859, 12, 3130, 770, 22701, 20328, 9640, 8978, 8315, 8922, 3331, 295, 3204, 5190, 3998, 18945, 2010, 502, 293, 2010, 568, 9673, 25720, 25724, 995, 10632, 36145, 13412, 16606, 21984, 44945, 24793, 1211, 20449, 29538, 27188, 13546, 41779, 9307], "avg_logprob": -0.23319893178119455, "compression_ratio": 1.5951417004048583, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 2607.14, "end": 2607.54, "word": "الـ", "probability": 0.7646484375}, {"start": 2607.54, "end": 2607.72, "word": " Cell", "probability": 0.53369140625}, {"start": 2607.72, "end": 2608.46, "word": "-mediated", "probability": 0.81982421875}, {"start": 2608.46, "end": 2609.16, "word": " immunity", "probability": 0.8134765625}, {"start": 2609.16, "end": 2609.88, "word": " هي", "probability": 0.84375}, {"start": 2609.88, "end": 2610.34, "word": " الأهم", "probability": 0.98828125}, {"start": 2610.34, "end": 2610.54, "word": " على", "probability": 0.95263671875}, {"start": 2610.54, "end": 2611.2, "word": " الإطلاق", "probability": 0.93701171875}, {"start": 2611.2, "end": 2611.58, "word": " في", "probability": 0.96630859375}, {"start": 2611.58, "end": 2612.22, "word": " حال", "probability": 0.990966796875}, {"start": 2612.22, "end": 2613.18, "word": " الـ", "probability": 0.754638671875}, {"start": 2613.18, "end": 2613.48, "word": " Herpes", "probability": 0.81982421875}, {"start": 2613.48, "end": 2613.78, "word": " virus", "probability": 0.5009765625}, {"start": 2613.78, "end": 2614.18, "word": " سميلي", "probability": 0.453125}, {"start": 2614.18, "end": 2614.56, "word": " و", "probability": 0.4814453125}, {"start": 2614.56, "end": 2614.76, "word": " كيف", "probability": 0.76708984375}, {"start": 2614.76, "end": 2615.04, "word": " عرفنا", "probability": 0.8611653645833334}, {"start": 2615.04, "end": 2615.32, "word": " إنها", "probability": 0.397705078125}, {"start": 2615.32, "end": 2615.6, "word": " الأهم", "probability": 0.880859375}, {"start": 2615.6, "end": 2615.76, "word": " على", "probability": 0.96142578125}, {"start": 2615.76, "end": 2616.72, "word": " الإطلاق؟", "probability": 0.89873046875}, {"start": 2616.72, "end": 2616.94, "word": " لما", "probability": 0.928955078125}, {"start": 2616.94, "end": 2617.36, "word": " عملنا", "probability": 0.9842122395833334}, {"start": 2617.36, "end": 2617.56, "word": " لها", "probability": 0.955322265625}, {"start": 2617.56, "end": 2618.08, "word": " suppression", "probability": 0.369140625}, {"start": 2618.08, "end": 2618.72, "word": " للـ", "probability": 0.83056640625}, {"start": 2618.72, "end": 2618.92, "word": " Cell", "probability": 0.8837890625}, {"start": 2618.92, "end": 2619.22, "word": "-mediated", "probability": 0.9523111979166666}, {"start": 2619.22, "end": 2619.66, "word": " immunity", "probability": 0.96142578125}, {"start": 2619.66, "end": 2620.58, "word": " صار", "probability": 0.855224609375}, {"start": 2620.58, "end": 2620.84, "word": " فينا", "probability": 0.93408203125}, {"start": 2620.84, "end": 2621.3, "word": " severe", "probability": 0.20556640625}, {"start": 2621.3, "end": 2621.96, "word": " cases", "probability": 0.94140625}, {"start": 2621.96, "end": 2622.36, "word": " of", "probability": 0.96875}, {"start": 2622.36, "end": 2622.82, "word": " Herpes", "probability": 0.823974609375}, {"start": 2622.82, "end": 2623.28, "word": " Simplex", "probability": 0.689208984375}, {"start": 2623.28, "end": 2623.74, "word": " type", "probability": 0.701171875}, {"start": 2623.74, "end": 2623.98, "word": " 1", "probability": 0.5439453125}, {"start": 2623.98, "end": 2624.2, "word": " and", "probability": 0.74169921875}, {"start": 2624.2, 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"duration_after_vad": 2517.678124999987}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..cdfd089972361df497f164417fd7f196ee3ba6c8
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/cCsE4tonvDg_raw.srt
@@ -0,0 +1,2340 @@
+1
+00:00:21,130 --> 00:00:23,490
+فبسم الله الرحمن الرحيم الحمد لله رب العالمين
+
+2
+00:00:23,490 --> 00:00:29,030
+اليوم ان شاء الله هو ال clinical virology و
+
+3
+00:00:29,030 --> 00:00:32,410
+clinical virology يعني نتكلم عن الفيروسات و نتكلم
+
+4
+00:00:32,410 --> 00:00:35,490
+عن ال diseases و عن ال mechanism by which they
+
+5
+00:00:35,490 --> 00:00:38,650
+produce the disease و عن ال treatment و عن ال
+
+6
+00:00:38,650 --> 00:00:42,270
+prevention و ايضا عن ال diagnosis يعني هي عبارة عن
+
+7
+00:00:42,270 --> 00:00:46,290
+diagnostic virology او medical virologyهنبدأ ان
+
+8
+00:00:46,290 --> 00:00:50,350
+شاء الله بال DNA enveloped viruses كما قسمنا
+
+9
+00:00:50,350 --> 00:00:52,430
+البكتيريا في السابق إلى gram positive و gram
+
+10
+00:00:52,430 --> 00:00:56,730
+negative وبسيلايكوكساي هنا بنقسمها إلى DNA viruses
+
+11
+00:00:56,730 --> 00:01:01,670
+و RNA viruses enveloped و non enveloped فبصينا دي
+
+12
+00:01:01,670 --> 00:01:05,710
+أربع نوع رئيسية DNA enveloped DNA non enveloped
+
+13
+00:01:05,710 --> 00:01:08,950
+RNA enveloped و RNA non enveloped هذا ان شاء الله
+
+14
+00:01:08,950 --> 00:01:15,830
+بمجموعة مهمة ليها DNA enveloped virusوأول فرد في
+
+15
+00:01:15,830 --> 00:01:19,730
+هذه المجموعة عائلة نسميها Herpes Viruses Family
+
+16
+00:01:21,070 --> 00:01:24,930
+وكونها family بيبقى فيها أعضاء كثر ومن أشهر
+
+17
+00:01:24,930 --> 00:01:28,130
+الأعضاء اللي موجودين أمامنا ال herpes simplex type
+
+18
+00:01:28,130 --> 00:01:32,630
+1 وهو صديق ملازم لكثير من البشر ال herpes simplex
+
+19
+00:01:32,630 --> 00:01:36,590
+type 2 هذا ليس صديق صديق إلا للعصار لأنه هذا بنتقل
+
+20
+00:01:36,590 --> 00:01:40,510
+عن طريق ال genes رقم تلاتة ال varicola zoster
+
+21
+00:01:40,510 --> 00:01:43,950
+virus وهذا في يوم من الأيام كنا عانينا منه أو
+
+22
+00:01:43,950 --> 00:01:46,730
+معظمنا عانينا منه اللي هو الجدر المي اللي بيسمونه
+
+23
+00:01:46,730 --> 00:01:50,380
+جدر المي أو chicken boxو يمكن لما نكبر في السن
+
+24
+00:01:50,380 --> 00:01:55,700
+شوية نصير نعاني من مين؟ من اللي هو ال exhaust رقم
+
+25
+00:01:55,700 --> 00:02:00,440
+أربع أطباء النساء والولادة بيخافوا كتير من هذا
+
+26
+00:02:00,440 --> 00:02:04,100
+الفيروس لإنه أحد الفيروسات اللي بتسبب congenital
+
+27
+00:02:04,100 --> 00:02:08,040
+abnormalitiesوشوفنا في ال classification of
+
+28
+00:02:08,040 --> 00:02:12,940
+medically important viruses ان ال CMV بينتقل من
+
+29
+00:02:12,940 --> 00:02:15,780
+الأم إلى الجانين، الجانين عبر ال placenta خلال
+
+30
+00:02:15,780 --> 00:02:20,920
+الحمل وقد ينتقل خلال أعمال الولادة وقد ينتقل من
+
+31
+00:02:20,920 --> 00:02:26,960
+الحليب عند الرضاة، إذا بتذكروا أن الطفل محاصر
+
+32
+00:02:26,960 --> 00:02:32,060
+بالثلاث اتجاهاترقم خمسة بيشتغل بيروس بيشتغل بيروس
+
+33
+00:02:32,060 --> 00:02:32,300
+بيشتغل بيروس بيشتغل بيروس بيشتغل بيروس بيشتغل
+
+34
+00:02:32,300 --> 00:02:34,400
+بيروس بيشتغل بيروس بيشتغل بيروس بيشتغل بيروس
+
+35
+00:02:34,400 --> 00:02:36,020
+بيشتغل بيروس بيشتغل بيروس بيشتغل بيروس بيشتغل
+
+36
+00:02:36,020 --> 00:02:38,060
+بيروس بيشتغل بيروس بيشتغل بيروس بيشتغل بيروس
+
+37
+00:02:38,060 --> 00:02:38,060
+بيشتغل بيروس بيشتغل بيروس بيشتغل بيروس بيشتغل
+
+38
+00:02:38,060 --> 00:02:41,340
+بيروس بيشتغل بيروس بيشتغل بيروس بيشتغل بيروس
+
+39
+00:02:41,340 --> 00:02:48,920
+بيشتغل بيروس بسرطان مشهور ومرتبط اما بالـ AIDS او
+
+40
+00:02:48,920 --> 00:02:53,660
+بذوي المناعة المنخفضة بسموه Kaposi's Sarcoma سرطان
+
+41
+00:02:53,660 --> 00:03:00,780
+كابوسي كمان و أصبح من الشيوع بدرجة انه لو رأينا
+
+42
+00:03:00,780 --> 00:03:05,780
+إنسان عنده Kaposi's Sarcoma نقول انه HIV إذا
+
+43
+00:03:05,780 --> 00:03:09,940
+مجموعة ضخمة من الفيروسات مهمة ومنتشرة بشكل كبير
+
+44
+00:03:09,940 --> 00:03:14,920
+يعني أعطيكم مثال مثلا رقم تلاتةالو الفارسيلازوستر
+
+45
+00:03:14,920 --> 00:03:20,540
+في الولايات المتحدة قبل 2001 كان يعتبر the most
+
+46
+00:03:20,540 --> 00:03:24,620
+common notifiable disease ايش يعني the most common
+
+47
+00:03:24,620 --> 00:03:29,380
+notifiable disease؟ الان في أمراض احنا بسميها
+
+48
+00:03:29,380 --> 00:03:32,580
+notifiable diseases يعني يدب الإبلاغ عنها، يدب
+
+49
+00:03:32,580 --> 00:03:36,800
+الإبلاغ عنها، ايش يدب الإبلاغ عنها؟ انا بقى ازالت
+
+50
+00:03:36,800 --> 00:03:41,740
+post على الفيسبوك شفتوا يمكن صارت تعوون في مجلد
+
+51
+00:03:41,740 --> 00:03:46,660
+أشقرالتعون internationally notifiable disease،
+
+52
+00:03:46,660 --> 00:03:49,580
+يعني لو صارت حالة في أي دولة في الدنيا، يجب أن
+
+53
+00:03:49,580 --> 00:03:53,000
+تعلم عنها مرضى الصحة العالمية، يجب أن تبلغ هذه
+
+54
+00:03:53,000 --> 00:03:58,040
+الجهة مرضى الصحة العالمية، فكلمة notifiable يعني
+
+55
+00:03:58,040 --> 00:04:02,120
+يجب الإبلاغ عنه، فبنقول إن chickenpox كان one of
+
+56
+00:04:02,120 --> 00:04:04,100
+the most common أو the most common notifiable
+
+57
+00:04:04,100 --> 00:04:09,010
+disease في الولايات المتحدة وإن في كل العالمالـ
+
+58
+00:04:09,010 --> 00:04:11,870
+Common Characteristics للعائلة للـ Herpes Virus
+
+59
+00:04:11,870 --> 00:04:17,530
+Family بشكل عام انه كلها كأفراد شكلا تشبه بعضها
+
+60
+00:04:17,530 --> 00:04:19,950
+البعض، يعني صعب نميز بينها بالـ electron
+
+61
+00:04:19,950 --> 00:04:23,650
+microscope رقم اتنين، They are Ecosahedral،
+
+62
+00:04:23,650 --> 00:04:27,470
+Ecosahedral يعني عشروني الوجوه Surrounded by a
+
+63
+00:04:27,470 --> 00:04:33,280
+lipoprotein envelope، وهذا ال envelopeهو الوحيد
+
+64
+00:04:33,280 --> 00:04:37,000
+الذي أُخذ من الـ nuclear membrane وليس من ال cell
+
+65
+00:04:37,000 --> 00:04:40,420
+membrane تمام يبقى ال herpes virus family تميزت
+
+66
+00:04:40,420 --> 00:04:44,220
+بإن ال envelope تبعها من ال nucleus وليس من ال
+
+67
+00:04:44,220 --> 00:04:49,680
+cytoplasm they do not contain a polymerase يعني
+
+68
+00:04:49,680 --> 00:04:52,900
+بتطلع نظيفة من الخليةوبتروح الخلية مش حاملة معاها
+
+69
+00:04:52,900 --> 00:04:56,580
+حاجة تمام؟ لا بتاخد هدية ولا بتحمل هدايا مافيش
+
+70
+00:04:56,580 --> 00:05:00,680
+polymerase مافيش polymerase عارفين ليش؟ لأنه DNA
+
+71
+00:05:00,680 --> 00:05:04,460
+فيروس وبتكاتر في النواة وبعدين بتكاتر في النواة
+
+72
+00:05:04,460 --> 00:05:09,440
+يبقى هياخد كل الأدوات بتاعة التكاتر وحنعرف من
+
+73
+00:05:09,440 --> 00:05:14,700
+ذكاؤه إنه إذا أراد دخول الخلية وعدم الإعلان عن
+
+74
+00:05:14,700 --> 00:05:18,240
+نفسه يعني common وهي صفة من صفات ال herpes virus
+
+75
+00:05:18,240 --> 00:05:23,790
+family لا يدخل إلى النواةيبقى وين؟ في الـcytoplasm
+
+76
+00:05:23,790 --> 00:05:26,950
+إذا بقى في الـcytoplasm لا حيصير له replication
+
+77
+00:05:26,950 --> 00:05:29,810
+ولا حيصير له transcription ولا حيصير له
+
+78
+00:05:29,810 --> 00:05:34,470
+translation وبالتالي مافيش protein تطلع منه تلتصق
+
+79
+00:05:34,470 --> 00:05:37,710
+بال membrane الخارجي للخلية المصابة يبقى
+
+80
+00:05:37,710 --> 00:05:42,070
+الـcytoxic T cell ستمر على هذه الخلية ولم تعرف أن
+
+81
+00:05:42,070 --> 00:05:47,150
+هناك فيروس يقطن داخلها إذن هي حركة ذكية منه إنه
+
+82
+00:05:47,150 --> 00:05:50,330
+يبقى وين؟ في الـcytoplasm في حالة الكمون في حالة
+
+83
+00:05:50,330 --> 00:05:55,020
+الكمونDouble-stranded DNA does not contain
+
+84
+00:05:55,020 --> 00:05:59,680
+polymerase بنسبة الحجم تبعه يعتبر الثاني في
+
+85
+00:05:59,680 --> 00:06:02,940
+الترتيب بعد ال box viruses ال box viruses اللي
+
+86
+00:06:02,940 --> 00:06:06,180
+منها ال smallpox والفاكسينيا فيروس أكبر في عيوسته
+
+87
+00:06:06,180 --> 00:06:10,910
+احنا المحاضرة السابقة لما اتكلمنا عنالـ viruses to
+
+88
+00:06:10,910 --> 00:06:14,730
+vaccinate against viruses، يعني نستخدم فيروس لما
+
+89
+00:06:14,730 --> 00:06:17,390
+نعمل طعام ضد فيروسات أخرى، سخدعنا الـ vaccinia
+
+90
+00:06:17,390 --> 00:06:22,890
+virus لأن حجمه كبير، أدواته، الجينات تبعته كتيرة
+
+91
+00:06:22,890 --> 00:06:27,530
+وبتلا ممكن نستبدلها بجينات أخرى، إذن هو ال herpes
+
+92
+00:06:27,530 --> 00:06:31,470
+virus هو الثاني في الحجم بعد مين بعد ال box virus
+
+93
+00:06:33,150 --> 00:06:36,410
+الـ Replication كنا بتم في النوكلياس و بيكون انترا
+
+94
+00:06:36,410 --> 00:06:40,550
+نوكليار انكلوجين يعني لو طلعنا تحت الميكروسكوب على
+
+95
+00:06:40,550 --> 00:06:45,290
+خلية مصابة هنلاقي بقايا الفيروس وين موجودة في
+
+96
+00:06:45,290 --> 00:06:49,810
+النوكلياس اسمه انترا نوكليار انكلوجين bodies are
+
+97
+00:06:49,810 --> 00:06:54,710
+the only viruses that obtain their envelope by
+
+98
+00:06:54,710 --> 00:06:58,230
+budding from the nuclear membrane اعتقد انه خلصها
+
+99
+00:06:58,230 --> 00:07:00,630
+من المعلومة دي ان هي الوحيدة اللي بتاخد من ال
+
+100
+00:07:00,630 --> 00:07:06,320
+nuclear membraneفيها تجمينت والتجمينت هوالبروتين
+
+101
+00:07:06,320 --> 00:07:10,780
+اللى مابين الكبسيد و مابين ال envelope وقلنا وظيفة
+
+102
+00:07:10,780 --> 00:07:16,080
+ال pigment انها مخزن ل regulatory proteins وكلمة
+
+103
+00:07:16,080 --> 00:07:18,700
+regulatory proteins هي البروتينات اللى بتعمل
+
+104
+00:07:18,700 --> 00:07:21,920
+regulation مثلا لترانسكيبشن و ترانسليشن بسموها
+
+105
+00:07:21,920 --> 00:07:25,920
+transcription and translation factors regulatory
+
+106
+00:07:25,920 --> 00:07:31,520
+proteins يعني بروتينات منظمة لعمليات الاكتار و ال
+
+107
+00:07:31,520 --> 00:07:31,940
+transcription
+
+108
+00:07:34,830 --> 00:07:37,230
+Herpes viruses are noted for their ability to
+
+109
+00:07:37,230 --> 00:07:40,030
+cause latent infection اعتقد ان كلمة latent
+
+110
+00:07:40,030 --> 00:07:44,410
+infection صارت سما مرتبط على مين بالـ Herpes virus
+
+111
+00:07:44,410 --> 00:07:47,430
+اللوحة اللي قدامنا فيها تلت نقاط مهمة طالع عليها
+
+112
+00:07:47,430 --> 00:07:51,210
+الأصفر على الجانب واحد ان ال nuclear membrane هذا
+
+113
+00:07:51,210 --> 00:07:56,870
+مميز تمام؟ اتنين ان ترى nuclear inclusions ان
+
+114
+00:07:56,870 --> 00:07:59,730
+الارض مؤشرة نفسك على طرف وين؟ في النواة latent
+
+115
+00:07:59,730 --> 00:08:04,250
+infection هذه تلت صفات مهمة جدا من هذه اللوحةالان
+
+116
+00:08:04,250 --> 00:08:07,030
+الـ latent infection تقريبا اللوحة اللي أمامنا هي
+
+117
+00:08:07,030 --> 00:08:11,910
+ما ذكرت لكم قبل قليل من انه الفيروس ينجح في البقاء
+
+118
+00:08:11,910 --> 00:08:15,750
+في الـcytoplasm وبالتالي لا يعبر عنه وبالتالي لن
+
+119
+00:08:15,750 --> 00:08:19,290
+يخرج منه بروتينات على سطح الخلية فلن يتم التعرف
+
+120
+00:08:19,290 --> 00:08:27,430
+عليه طيب اذا بنقول latent يعني كامن هل يعود مرة
+
+121
+00:08:27,430 --> 00:08:32,170
+أخرى؟إيش .. إيش بنسمي العودة؟ reactivation ال
+
+122
+00:08:32,170 --> 00:08:36,410
+infection الأولى إيش بنسميها؟ primary infection و
+
+123
+00:08:36,410 --> 00:08:40,130
+أي subsequent infection بنسميها reactivation إنه
+
+124
+00:08:40,130 --> 00:08:46,130
+صارله activation مرة أخرى غالبا ال reactivation
+
+125
+00:08:46,130 --> 00:08:49,830
+تشبه ال primary infection يعني طلعتله حب هنا
+
+126
+00:08:49,830 --> 00:08:54,230
+تطلعله مرة تانية حب هنا ال primary infection تشبه
+
+127
+00:08:54,230 --> 00:08:59,250
+قلنا مين؟ مع أن البعض بيقول في المهاجة إنهالـ
+
+128
+00:08:59,250 --> 00:09:01,770
+primary infection is usually more severe أنا بفتر
+
+129
+00:09:01,770 --> 00:09:07,510
+في الصحيح مع هذا القول لأن ال severity لل herpes
+
+130
+00:09:07,510 --> 00:09:11,990
+virus family غالبا مرتبطة بال degree of immunity
+
+131
+00:09:11,990 --> 00:09:16,130
+فلما دخل الفيروس كيف كان الوضع تبقى المناعة بيكون
+
+132
+00:09:16,130 --> 00:09:21,290
+ال severity تبقى اللي هو ال infection لكن الشهدة
+
+133
+00:09:21,290 --> 00:09:24,570
+الموضوع ان ال primary infection شبه مين ال
+
+134
+00:09:24,570 --> 00:09:29,440
+reactivation لكن ال Varicella Zosterالـ Chickenpox
+
+135
+00:09:29,440 --> 00:09:33,500
+بيغطي كل الجسم بينما الزوستر الحزام الناري بيغطي
+
+136
+00:09:33,500 --> 00:09:39,140
+جزء من الجسم ايش السبب في الاختلاف يا بنادر السبب
+
+137
+00:09:39,140 --> 00:09:43,240
+في الاختلاف في ال primary infection انه ماكانش فيه
+
+138
+00:09:43,240 --> 00:09:46,880
+antibodies فبتالي الفيروس استطاع ان يصل الى جميع
+
+139
+00:09:46,880 --> 00:09:52,210
+الحواق الجسم بس في ال reactivation هو كان مختبئفي
+
+140
+00:09:52,210 --> 00:09:57,050
+خط اللي هو ال nerve تمام؟ فنفترض أنه طلع أمام
+
+141
+00:09:57,050 --> 00:10:02,150
+العرين تبعه اللي هو ال nerve و سطع أن يحدث عدوى في
+
+142
+00:10:02,150 --> 00:10:07,450
+هذه المنطقة لكن لم يسطع الانتشار إلى باقي الجسم
+
+143
+00:10:07,450 --> 00:10:12,030
+بسبب وجود مين الآن؟ antibodies ال varicella zoster
+
+144
+00:10:12,030 --> 00:10:15,880
+هو فيروس واحد يا جماعةو .. و .. و لما بيكون اسمه
+
+145
+00:10:15,880 --> 00:10:19,900
+Varicella بيكون نفس الفيروس اللي بيكون هو Zoster
+
+146
+00:10:19,900 --> 00:10:22,080
+لإنه ماصارش تغيير في ال genes تبعته أو ال .. أو ال
+
+147
+00:10:22,080 --> 00:10:26,240
+antigenet إنما اللي صار تغيير فيه قلنالكوا إنه في
+
+148
+00:10:26,240 --> 00:10:28,580
+حالة ال primary اللي هي ال .. اللي هي Varicella
+
+149
+00:10:28,580 --> 00:10:34,220
+تكون antibody لاحقا منعت انتشاره لما ظهر بشكل
+
+150
+00:10:34,220 --> 00:10:38,400
+Zoster تمام؟ و في هذا نقطة بدنا نحكيلكوا إياها و
+
+151
+00:10:38,400 --> 00:10:44,160
+نناقشها مع بعضلما بينصابوا الأطفال بالفارسيلا اللى
+
+152
+00:10:44,160 --> 00:10:47,980
+ال chickenpox بيكون ال disease غالبا mild .. mild
+
+153
+00:10:47,980 --> 00:10:51,520
+يعني خفيف لكن لو لا قدر الله انتوا انصبتوا فيه
+
+154
+00:10:51,520 --> 00:10:55,080
+الآن وانتوا ماكنتوش مصابين وانتوا صغار بيكون very
+
+155
+00:10:55,080 --> 00:11:01,260
+severe .. severe للكبار و mild للصغار .. هل من
+
+156
+00:11:01,260 --> 00:11:07,540
+تفسير؟ ايش مال المناعة؟ بتكون اني .. وين افضل
+
+157
+00:11:07,540 --> 00:11:14,170
+بتكون المناعة؟لأ المناعة بتكون أفضل هون و هم صغار،
+
+158
+00:11:14,170 --> 00:11:19,610
+الجواب صحيح بس التفسير غلط، هي إيه علاقة بالمناعة؟
+
+159
+00:11:19,610 --> 00:11:22,920
+أصلا الدررو ال .. و ال .. ال .. ال physicals اللي
+
+160
+00:11:22,920 --> 00:11:26,060
+نتجهة .. هي نتجهة من وين هي؟ نتجهة من إنه جهاز
+
+161
+00:11:26,060 --> 00:11:29,620
+المناعة has attacked اللي هو ال .. ال .. ال .. ال
+
+162
+00:11:29,620 --> 00:11:32,320
+virally infected cell فلما منعتي أنا وأنا كبير
+
+163
+00:11:32,320 --> 00:11:37,120
+تكون عالية، الأثار تبعها هيكون عالي، بينما لو كانت
+
+164
+00:11:37,120 --> 00:11:40,940
+منخفض، هيكون أثارها برضه منخفض، لذلك كانت mild في
+
+165
+00:11:40,940 --> 00:11:44,520
+الأصغار و severe في من في الأكبر، أرجو أن تكون
+
+166
+00:11:44,520 --> 00:11:45,820
+النقطة هذه واضحة
+
+167
+00:11:48,580 --> 00:11:53,540
+بعض التفسير أو جدول هذا يناقش مجموعة من الانتقاط
+
+168
+00:11:53,540 --> 00:12:00,480
+المتعلقة بالست فيروسات الموجودة في المجموعة مثلا
+
+169
+00:12:00,480 --> 00:12:05,740
+ال HSV-1 وال HSV-2 والفارسيلازوستر هذوله بيشبهوا
+
+170
+00:12:05,740 --> 00:12:09,400
+بعض لدرجة كبيرة فخلينا نحطهم في نصف جدول لحالهم
+
+171
+00:12:10,550 --> 00:12:13,450
+اطلع الـ Root of Transmission على العمود الأخير،
+
+172
+00:12:13,450 --> 00:12:16,810
+هلاج أنه بيه Respiratory Secretions and Saliva،
+
+173
+00:12:16,810 --> 00:12:21,070
+إنما الثاني Sexual Contact و Perinatal Infection،
+
+174
+00:12:21,070 --> 00:12:25,370
+طبعا الـ Perinatal يعني اللي علاقة بالولادة، الطفل
+
+175
+00:12:25,370 --> 00:12:29,370
+بيولد لأم مصابة بالفيروس بياخد هذا الفيروس معناه
+
+176
+00:12:29,820 --> 00:12:33,100
+رقم تلاتة هي Respiratory Secretions، إذا الأول
+
+177
+00:12:33,100 --> 00:12:37,100
+والثالث Respiratory Secretions، بينما التاني هذا
+
+178
+00:12:37,100 --> 00:12:41,700
+Unique، مميز لأنه Sexually Transmitted بالنسبة لـ
+
+179
+00:12:41,700 --> 00:12:45,680
+Recurrent Infection الأخير، بيكون زوستر، احنا
+
+180
+00:12:45,680 --> 00:12:50,660
+قولنا الأولى Varicella، والتانية زوستر، بينما في
+
+181
+00:12:50,660 --> 00:12:54,980
+ال Herpes Simplex Type 2 Herpes Genitalis، وكلمة
+
+182
+00:12:54,980 --> 00:12:57,060
+Herpes Genitalis تتوحى بأن الـ Herpes هذا موجود
+
+183
+00:12:57,060 --> 00:13:01,550
+علوان على الـ Genital Areaالـ Recurrent Infection
+
+184
+00:13:01,550 --> 00:13:04,850
+في الـ Herpes Simplex Type I Herpes Labialis وكلمة
+
+185
+00:13:04,850 --> 00:13:07,590
+Labialis يعني على الشفتين على أي من على أي منطقة
+
+186
+00:13:07,590 --> 00:13:11,650
+من الشفتين Encephalitis يعني اعتلال الدماغ و
+
+187
+00:13:11,650 --> 00:13:16,570
+Keratitis طبعا اللي هي العين الطلاب على ال ال
+
+188
+00:13:16,570 --> 00:13:19,950
+primary infection أنا بتخيل أنه كان الأفضل علينا
+
+189
+00:13:19,950 --> 00:13:23,680
+احنا ان نحطاللي كان فى ال current .. فى ال
+
+190
+00:13:23,680 --> 00:13:26,220
+recurrent infection هطلوين كمان فى ال primary
+
+191
+00:13:26,220 --> 00:13:31,260
+infection ما عدا الأخير الفرسيلة والزاستر لإنه
+
+192
+00:13:31,260 --> 00:13:34,600
+بالفعل ممكن تكون ال primary infection كيراتيتس
+
+193
+00:13:34,600 --> 00:13:40,340
+ممكن تكون herpes labialis من الأساس لكن الشيء
+
+194
+00:13:40,340 --> 00:13:42,680
+الوحيد اللي هم محقين فيه ان يضعوه فى ال residual
+
+195
+00:13:42,680 --> 00:13:48,020
+فى ال recurrent هو ال encephalitis وطبعا هنا ممكن
+
+196
+00:13:48,020 --> 00:13:50,990
+يبقى لها كمان يصير فيه complicationفي ال herpes
+
+197
+00:13:50,990 --> 00:13:54,750
+genitalis يصيب لنا حاجة اسمها meningitis إذا في
+
+198
+00:13:54,750 --> 00:13:58,590
+عندي encephalitis في herpes simplex type 1 herpes
+
+199
+00:13:58,590 --> 00:14:01,450
+simplex type 2 إيش هيكون عنها؟ meningitis و
+
+200
+00:14:01,450 --> 00:14:05,230
+بيسموها aseptic meningitis إيش يعني aseptic
+
+201
+00:14:05,230 --> 00:14:12,340
+meningitis؟ septic يعني فيها بكتيريااسبتك مافيهاش
+
+202
+00:14:12,340 --> 00:14:16,900
+بكتيريا او بالاخرى يعني كيف .. كيف بنفسرها تطبيعا؟
+
+203
+00:14:16,900 --> 00:14:21,000
+احنا بنقول انه يطلق كلمة aseptic meningitis او
+
+204
+00:14:21,000 --> 00:14:25,220
+aseptic arthritis على سبب المثال على واحد عنده
+
+205
+00:14:25,220 --> 00:14:31,580
+meningitis او عنده arthritis وخدنا منه سائل CSF او
+
+206
+00:14:31,580 --> 00:14:36,080
+synovial fluid وعملنا له culture ولم يخرج معنا اي
+
+207
+00:14:36,080 --> 00:14:39,620
+شيء ماقدرناش نعزل اي حاجة في فترة حلقة بسموها ايه؟
+
+208
+00:14:40,600 --> 00:14:45,340
+من meningitis أو aseptic arthritis طبعا لاحظوا ان
+
+209
+00:14:45,340 --> 00:14:50,040
+كلهم بيعملوا لتنسي واحد بيعمل في ال cranial
+
+210
+00:14:50,040 --> 00:14:53,920
+sensory ganglia وفي ال lumbar or sacral sensory
+
+211
+00:14:53,920 --> 00:14:57,340
+ganglia والاخير بيعمل برضه في cranial وthoracic
+
+212
+00:14:57,340 --> 00:15:04,370
+sensory ganglia وطبعا مكان ال commonهو المكان
+
+213
+00:15:04,370 --> 00:15:07,530
+الخروج ال recurrence لما انا بقول في الكرانية
+
+214
+00:15:07,530 --> 00:15:10,290
+لغاية في الكرانية يعني في ال .. في الرأس مظبوط في
+
+215
+00:15:10,290 --> 00:15:14,650
+الرأس يعني الوجه الوجه يعني الشفتان والعين اللي
+
+216
+00:15:14,650 --> 00:15:17,590
+هنقولنا عنها ممكن ينصبوا بال recurrent infection
+
+217
+00:15:17,590 --> 00:15:22,170
+بينما في ال .. ال .. ال .. ال genital herpes الأمر
+
+218
+00:15:22,170 --> 00:15:26,570
+مختلف المكان قريب برضه من ال genitalالـ Epstein
+
+219
+00:15:26,570 --> 00:15:30,150
+-Barr Virus والـ Cytomegalovirus والـ Human
+
+220
+00:15:30,150 --> 00:15:33,890
+Herpesvirus Type 8 نفس الفكرة لـ Primary
+
+221
+00:15:33,890 --> 00:15:38,310
+Infections في انحاسمة Infectious Mononucleosis و
+
+222
+00:15:38,310 --> 00:15:41,630
+Congenital Infection اللي هي الـ In-Utero يعني في
+
+223
+00:15:41,630 --> 00:15:50,730
+المرحلة الجنينية و Mononucleosis ال usual اللي
+
+224
+00:15:50,730 --> 00:15:56,060
+تنسي وهو على فكرة هنستخدمه كمان شوية فيتصنيف الـ
+
+225
+00:15:56,060 --> 00:16:00,140
+Herpesviruses إلى Alpha, Beta وGamma، تمام؟ وين
+
+226
+00:16:00,140 --> 00:16:05,280
+الـ tissue اللي بينصاب من هذا الفيروس، فمثلا عندنا
+
+227
+00:16:05,280 --> 00:16:08,280
+الـ B lymphocytes كلمة uncertain, uncertain يعني
+
+228
+00:16:08,280 --> 00:16:13,880
+ماعناش، خدنا نقول معلومات مؤكدة عن مكان الكمة،
+
+229
+00:16:13,880 --> 00:16:18,780
+لحظة في هذا ال .. في هذه اللوحةالـ Recurrent
+
+230
+00:16:18,780 --> 00:16:22,580
+Infection None في الـ Epstein-Barr Virus و
+
+231
+00:16:22,580 --> 00:16:26,000
+Asymptomatic Shedding في مين؟ في الـ
+
+232
+00:16:26,000 --> 00:16:28,720
+cytomegalovirus كلمة Asymptomatic Shedding يعني
+
+233
+00:16:28,720 --> 00:16:34,040
+الفيروس بينتج من المريض لكن لا يقول أي أعراض ولا
+
+234
+00:16:34,040 --> 00:16:35,840
+أي ضرر من هذا الفيروس
+
+235
+00:16:38,490 --> 00:16:43,330
+لو مافيش اعراض كان مادرسنهوش هنا لكن انا قلتلكوا
+
+236
+00:16:43,330 --> 00:16:50,070
+قبل قليل ان ال CMV احد اهم مسببات ال congenital
+
+237
+00:16:50,070 --> 00:16:54,030
+abnormalities في الولايات المتحدة نسبة كبيرة من
+
+238
+00:16:54,030 --> 00:16:57,990
+الناس قد تصل الى تمانين بالمائة عندهم antibody لل
+
+239
+00:16:57,990 --> 00:17:01,930
+cytomegalovirus يعني احنا من مائة شخص هنا تمانين
+
+240
+00:17:01,930 --> 00:17:08,520
+هنا هيكون CMV فانتشاره واسع لكنلا يوجد لدينا
+
+241
+00:17:08,520 --> 00:17:12,460
+vaccine للـ CMV وهذا بإن نحطه على علامة الستثناب،
+
+242
+00:17:12,460 --> 00:17:16,460
+مع أن هو Zero-Type-1، يعني الحجة اللي كنا ناخدها
+
+243
+00:17:16,460 --> 00:17:20,340
+في القرار بإنه فيها أكتر من Zero-Type، لماذا لا
+
+244
+00:17:20,340 --> 00:17:25,640
+يوجد vaccine لهذا الـ Zero-Type؟بدي احكي شغل مهم
+
+245
+00:17:25,640 --> 00:17:29,680
+جدا لما نفكر في ال vaccine لازم ال vaccine كله
+
+246
+00:17:29,680 --> 00:17:35,120
+مردودين مردود صحي تمام؟ ونشوف هل المردود الصحي
+
+247
+00:17:35,120 --> 00:17:41,000
+يعني مستاهل التكاريف اللي احنا ننفقها على هذا ال
+
+248
+00:17:41,000 --> 00:17:45,460
+vaccine ولا لأ؟ وهل هناك بالفعل مدار صحية خطيرة
+
+249
+00:17:45,460 --> 00:17:49,940
+كبيرة من هذا الفيروس ولا لأ؟ ليش؟ لأن احنا بنقول
+
+250
+00:17:49,940 --> 00:17:54,800
+الاستثمار في الصحة بيجي برضه من خلال الأولوياتمين
+
+251
+00:17:54,800 --> 00:17:58,740
+الأولوية القصوى ان ندور عليه الان مثلا ال HIV
+
+252
+00:17:58,740 --> 00:18:02,820
+أولوية عن كل الأمراض ال tuberculosis أولوية عن
+
+253
+00:18:02,820 --> 00:18:05,960
+الأمراض الأخرى وبالتالي الموضوع المتعلق بيه ايضا
+
+254
+00:18:05,960 --> 00:18:11,380
+أولويات ال research وأولويات الصحة العامة بشكل عام
+
+255
+00:18:11,380 --> 00:18:14,560
+الأخير
+
+256
+00:18:14,560 --> 00:18:18,600
+طبعا انا قلنالكوا انه مابنعرفش يعني اصلا عنه حاجة
+
+257
+00:18:18,600 --> 00:18:21,120
+الا انه بيعمل cabooses sarcoma
+
+258
+00:18:25,850 --> 00:18:30,010
+الأوليات هو ان هو ال virus منتشر بشكل كبير بين
+
+259
+00:18:30,010 --> 00:18:33,650
+الناس و انه نسبة ضائلة جدا لمن يعاني من هذا ال
+
+260
+00:18:33,650 --> 00:18:36,350
+virus نسبة ضائلة مانتشر الولايات الولايات يعني
+
+261
+00:18:36,350 --> 00:18:40,350
+ماعملتلوش؟ لأ مش قادرين يعملوله لأنه زي ما حكيت
+
+262
+00:18:40,350 --> 00:18:44,530
+لكوا الفكرة فيه انه نسبة كبيرة من الناس مصابين
+
+263
+00:18:44,530 --> 00:18:48,340
+asymptomatic infectionيعني زي الـ Toxoplasmosis
+
+264
+00:18:48,340 --> 00:18:51,960
+الـ Toxoplasmosis على سبيل المثال منتشر بنسبة
+
+265
+00:18:51,960 --> 00:18:55,740
+كبيرة جدا، تمام؟ لكن مافيش أي أعراض له، مافيش أي
+
+266
+00:18:55,740 --> 00:19:01,060
+مضار له، فليش هنكلف الدولة أموال طايلة لإنتاج
+
+267
+00:19:01,060 --> 00:19:06,600
+vaccine لمرض مثلا بسببش حالات كثيرة من الضرر
+
+268
+00:19:06,600 --> 00:19:10,940
+للبشر؟ وفي كمان نقطة تانية، ال بيسم تبع الإنسان
+
+269
+00:19:10,940 --> 00:19:14,860
+اللي ما بتحملش vaccine يعني أنا أطعمه لكل
+
+270
+00:19:21,360 --> 00:19:24,720
+لو زاد تركيز ال antibodies في ال serum بيظهر عينا
+
+271
+00:19:24,720 --> 00:19:30,940
+عراض مرضية بيسموها serum sicknessطيب في شغل مهمة
+
+272
+00:19:30,940 --> 00:19:34,400
+في ال herpes virus family اللي هو ال rashes و حد
+
+273
+00:19:34,400 --> 00:19:38,200
+مسميها ال vesicular rashes و كلمة vesicular يعني
+
+274
+00:19:38,200 --> 00:19:43,520
+حوائي صلاطي يعني بيكون فيه قشرة رقيقة شفافة من
+
+275
+00:19:43,520 --> 00:19:49,140
+الجل و جواها سائل هذا السائل اما clear او slightly
+
+276
+00:19:49,140 --> 00:19:52,680
+turbid clear لان هو اصلا clear لانه بيسموه serious
+
+277
+00:19:52,680 --> 00:19:56,780
+fluid و slightly turbid لانه ممكن يكون فيه cell
+
+278
+00:19:56,780 --> 00:20:01,830
+debris و الفيروس نفسهالفيروس نفسه بيكون موجود في
+
+279
+00:20:01,830 --> 00:20:04,690
+هذه ال physical يبقى لما نشوف الحزام ناري مثلا على
+
+280
+00:20:04,690 --> 00:20:08,870
+اسم المثال اللي هي ال zoster هذه كويس واضحة هي
+
+281
+00:20:08,870 --> 00:20:13,240
+مثلا في physical واضحةوهنا في physical واضحة طبعا
+
+282
+00:20:13,240 --> 00:20:16,900
+ال physical ما بتبدأ physical تبدأ احمرار زي رش و
+
+283
+00:20:16,900 --> 00:20:20,240
+بعدين بتتكون ال physical تبقى على سائل و ممكن
+
+284
+00:20:20,240 --> 00:20:23,660
+تنفجر هذا ال physical و بعدين يصير لها crustacea
+
+285
+00:20:23,660 --> 00:20:28,620
+يعني تصير لها قشور و بعدين تشفى تماما ولا تترك اي
+
+286
+00:20:28,620 --> 00:20:35,960
+اثار الا اذا قمنا بحكهاو تم التهاب آخر ثانوي
+
+287
+00:20:35,960 --> 00:20:41,080
+ببكتيريا في نفس الموقع فبالتالي ممكن يصير فينا
+
+288
+00:20:41,080 --> 00:20:46,200
+Scarring أو ندوب ناتج عن هذه ال Vesicles بتميز
+
+289
+00:20:46,200 --> 00:20:52,340
+اللي هو ال .. ال .. ال .. ال .. الفيروسات الثلاثة
+
+290
+00:20:52,340 --> 00:20:55,200
+Herpes simplex type 1 و type 2 و ال Varicella
+
+291
+00:20:55,200 --> 00:20:58,440
+zoster بإن هما هما التلاتة بشكله اللي هو ال
+
+292
+00:20:58,440 --> 00:21:01,850
+vesicular rashesطبعاً أنا قلتلكوا الـ vesicular
+
+293
+00:21:01,850 --> 00:21:08,150
+rash بيتمد على ال disease، إذا كان Varicella زوستر
+
+294
+00:21:08,150 --> 00:21:13,390
+في كل الجسم، إذا كان زوستر في مكان محدد، إذا كان
+
+295
+00:21:13,390 --> 00:21:17,290
+herpes simplex type 1 غالبا في منطقة الوجهة، إذا
+
+296
+00:21:17,290 --> 00:21:20,030
+كان herpes simplex type 2 اللي هو في منطقة الـ
+
+297
+00:21:20,030 --> 00:21:24,100
+genital areaالـ Cytomegalovirus قبل ما ننهي من
+
+298
+00:21:24,100 --> 00:21:28,980
+اللوحة الـ CMV والإبشتينبعارفيروس كلهما ما بيعملوا
+
+299
+00:21:28,980 --> 00:21:36,100
+أي Vesicular rash قلنا كما وعدناكم أن نقسم الـ
+
+300
+00:21:36,100 --> 00:21:39,700
+Herpesvirus family إلى تلات أقسام Alpha Beta
+
+301
+00:21:39,700 --> 00:21:46,050
+وGammaوالتقسيمة مبنية على مكان تكاثر او ال tissue
+
+302
+00:21:46,050 --> 00:21:51,050
+اللي بيستقبل من اللي بيستقبل اللي هم الفيروسات هذه
+
+303
+00:21:51,050 --> 00:21:54,870
+مثلا ال alpha viruses اللي هم اطلعت من نفسهم اللي
+
+304
+00:21:54,870 --> 00:21:58,810
+ذكرتهم قبل قليل ال one و ال two و ال varicella
+
+305
+00:21:58,810 --> 00:22:05,870
+zoster virus بيهجموا من ال epithelial cells و طبعا
+
+306
+00:22:05,870 --> 00:22:10,110
+بيكملوا في ال neurons بينما ال gamma viruses اللي
+
+307
+00:22:10,110 --> 00:22:15,230
+هي التالتةاللي بتشمل الابستين بارفيروس وال human
+
+308
+00:22:15,230 --> 00:22:19,710
+herpes type 8 they infect and become latent
+
+309
+00:22:19,710 --> 00:22:23,430
+primarily in lymphoid tissue إذن Epithelial،
+
+310
+00:22:23,430 --> 00:22:25,710
+lymphoid tissue طب اللي في النص اللي هي ال beta
+
+311
+00:22:25,710 --> 00:22:31,590
+variety of tissues يعني أنسجة مختلفة ومتنوعة
+
+312
+00:22:31,590 --> 00:22:36,510
+وبالتالي يعني مابنقدرش نحصلها في نسيج محدد منها ال
+
+313
+00:22:36,510 --> 00:22:41,070
+CNV يعني ال CNV مثلا من الأماكن المفضلة له الكلية
+
+314
+00:22:42,450 --> 00:22:47,830
+الـ kidney ال kidney ال transplant مش هنقول إنه ال
+
+315
+00:22:47,830 --> 00:22:51,070
+kidney transplant أحد الأشياء اللي .. اللي صارت
+
+316
+00:22:51,070 --> 00:22:56,110
+جزء من نقل ال CMV فبالتالي يعني لازم يكون فيه
+
+317
+00:22:56,110 --> 00:23:00,550
+فحوصات لل donors، تمام؟ ليش الآن احنا خايفين؟ جابش
+
+318
+00:23:00,550 --> 00:23:03,150
+اللي احنا كنا بنطمنين الناس و بنقولهم إنه مابلزمش
+
+319
+00:23:03,150 --> 00:23:08,480
+فكس هناش لإن المرض ضعيف، بسببش خطرتنسوش لما بننقل
+
+320
+00:23:08,480 --> 00:23:12,040
+احنا transplant لمريد احنا بنعطيه
+
+321
+00:23:12,040 --> 00:23:15,640
+immunosuppressive agent احنا بنطبطله جهاز المناعة
+
+322
+00:23:15,640 --> 00:23:18,740
+يعني الفيروس اذا كان مولود في الكيليا الجديدة اللي
+
+323
+00:23:18,740 --> 00:23:24,680
+نقلناها لو نقلناها حينشط ويتكاثر دون حسيب او رقيب
+
+324
+00:23:24,680 --> 00:23:30,390
+وبتالي قد يحدث ضرر لهذا المرضطبعا بتاعوا هنا في
+
+325
+00:23:30,390 --> 00:23:33,230
+غزة صار فينا kidney transplantation كل سنة بيجوا
+
+326
+00:23:33,230 --> 00:23:39,830
+مجموعة من طباء العرب والفلسطينين في معظمهم من
+
+327
+00:23:39,830 --> 00:23:44,210
+فرنسا ومن بريطانيا وبيعملوا عمليات زراعة كيليا لكن
+
+328
+00:23:44,210 --> 00:23:51,630
+لحد الآن الفحوصات بتتم خارج البلاد وفي مساعي حديثة
+
+329
+00:23:51,630 --> 00:23:58,330
+لإنشاء مختبر و تقريبا شبه جاهزليه؟ انه يعملوا
+
+330
+00:23:58,330 --> 00:24:00,890
+matching ويعملوا testing ل .. اللي هو ال donors
+
+331
+00:24:00,890 --> 00:24:04,430
+لخلوهم من الأمراض اللي ممكن تنتقل بال .. بال
+
+332
+00:24:04,430 --> 00:24:10,230
+transplant طيب هذا كمان جدول حلو و جمال هذا جدول
+
+333
+00:24:10,230 --> 00:24:15,150
+بإنه بيجمعلي بعض الحقائق مع بعضها طلعولي على ال
+
+334
+00:24:15,150 --> 00:24:19,570
+antiviral therapy acyclover .. acyclover ..
+
+335
+00:24:19,570 --> 00:24:24,040
+acyclover .. لمين؟الألفة للألفة للتلاتة اللي احنا
+
+336
+00:24:24,040 --> 00:24:26,640
+ذكرناهم alpha اللي هم ال herpes simplex type 1 و
+
+337
+00:24:26,640 --> 00:24:31,020
+type 2 و ال varicella zoster كمان التلاتة أحد
+
+338
+00:24:31,020 --> 00:24:35,780
+الوسائل المهمة جدا لتشخيصهم هو ال culture cell
+
+339
+00:24:35,780 --> 00:24:42,350
+culture بالنسبة لل fetal or neonatal infectionبس
+
+340
+00:24:42,350 --> 00:24:45,990
+ال herpes simplex type 2 لأنه زي ما حكينالكوا هو
+
+341
+00:24:45,990 --> 00:24:50,490
+ده خارج الطفل ممكن ياخد من الأم ال virus لكن type
+
+342
+00:24:50,490 --> 00:24:55,310
+1 و ال varicella مافيش خوف من انتقالهم من الأم إلى
+
+343
+00:24:55,310 --> 00:25:01,640
+الجنينبالنسبة ل ال giant cell produced طلعه واحد
+
+344
+00:25:01,640 --> 00:25:07,400
+اتنين تلاتة اربع اربع yes و ال ابشتين بار فيروس و
+
+345
+00:25:07,400 --> 00:25:13,480
+ال human herpes virus type 8 مابيعملوش عارفين ليش؟
+
+346
+00:25:13,480 --> 00:25:17,880
+لأنه التنين specifically بروح على مين؟ على ال
+
+347
+00:25:17,880 --> 00:25:21,860
+lymphoid tissue و اصلا شغلهم سرطانات دول متخصصين
+
+348
+00:25:21,860 --> 00:25:24,560
+في السرطانات مش متخصصين في انهم يعملوا multi
+
+349
+00:25:24,560 --> 00:25:29,570
+nucleated giant cellمن المطيف اسم الـCMV
+
+350
+00:25:29,570 --> 00:25:32,810
+Cytomegalovirus
+
+351
+00:25:32,810 --> 00:25:37,350
+عارفين ايش معناته بالعربي؟ الفيروس المضخم للخلايا
+
+352
+00:25:37,350 --> 00:25:41,370
+اللي احنا نتكلم عن الـGiant Cells وطالي اسم ال ..
+
+353
+00:25:41,370 --> 00:25:44,670
+ال .. ال .. اسم الفيروس أُخذ من شكل ال .. شكل
+
+354
+00:25:44,670 --> 00:25:47,890
+الـCPE على الـCell Culture الـCPE يعني Cytopathic
+
+355
+00:25:47,890 --> 00:25:54,490
+Effect طيب في عندي في ال culture هنا في عندي حد
+
+356
+00:25:54,490 --> 00:25:58,830
+اسم هيتروفيل شفتها؟هيتروفيل وفيه DNA props DNA
+
+357
+00:25:58,830 --> 00:26:02,550
+props يعني بال molecular techniques لكن إيش يعني
+
+358
+00:26:02,550 --> 00:26:07,450
+الهيتروفيل؟ ولمين؟ للإيبشتين بار فيروس الهيتروفيل
+
+359
+00:26:07,450 --> 00:26:14,170
+معناها antibody بيتفاعل مع انتجن ليس سبب إنتاجه
+
+360
+00:26:14,170 --> 00:26:17,270
+ناقيتها؟
+
+361
+00:26:17,270 --> 00:26:20,930
+antibody المفروض بيتفاعل عن أيه ال antibody؟ مع
+
+362
+00:26:20,930 --> 00:26:24,530
+الانتجن اللي سبب خروجه صح ولا لأ؟ بيكونوا specific
+
+363
+00:26:25,910 --> 00:26:30,790
+الجينة Antibody بتفعل مع أنتجينات أخرى غير لسببات
+
+364
+00:26:30,790 --> 00:26:34,410
+إنتاجها فسموها heterofil antibody طبعا هذا كله
+
+365
+00:26:34,410 --> 00:26:40,050
+منطبق على مجموعة لكن هذا الفحص أخذ الاسم الوحيد
+
+366
+00:26:40,050 --> 00:26:44,450
+اللي أخد الاسم هذا الفحص اسمه heterofil antibody
+
+367
+00:26:44,450 --> 00:26:49,090
+test وبنشخص فيه مين الـ Epstein-Barr virus طبعا هو
+
+368
+00:26:49,090 --> 00:26:51,850
+مش فحص دقيق لكن موجود
+
+369
+00:26:58,310 --> 00:27:02,550
+أنا بكون عندي أنتجينات محددة و باخد من المريض
+
+370
+00:27:02,550 --> 00:27:06,250
+serum تمام؟ بكشف بالأنتجينات المحددة اللي عندي هذه
+
+371
+00:27:06,250 --> 00:27:10,310
+عن هذا ال antibody تمام؟ اللي احنا سميناه هيتروفيل
+
+372
+00:27:10,310 --> 00:27:14,350
+بسبب أنه بتفعل مع أنتجينات أخرى غير ال antigen
+
+373
+00:27:14,350 --> 00:27:17,690
+اللي سبب منها يعني ال cross reactivity تبعت مالها
+
+374
+00:27:17,690 --> 00:27:18,910
+عالية جدا
+
+375
+00:27:23,720 --> 00:27:27,800
+Tumor Herpes Viruses احنا ذكرنا قبل القيلس انه في
+
+376
+00:27:27,800 --> 00:27:32,880
+بعض الفيروسات مش متخصصة لتعمل جانس وان انا متخصص
+
+377
+00:27:32,880 --> 00:27:35,620
+في ال lymphoid tissue وممكن تعمل سرطانات مثلا
+
+378
+00:27:35,620 --> 00:27:40,320
+الابيشتينبارفيروس is associated with Birkitt's
+
+379
+00:27:40,320 --> 00:27:43,700
+lymphoma اقرأولي بالله الجملة اللي قولها قبل
+
+380
+00:27:43,700 --> 00:27:48,320
+certain herpes viruses are suspected طبعا الجملة
+
+381
+00:27:48,320 --> 00:27:52,460
+هذه بندرسها من اكم سنة من سنين وبنقول suspected
+
+382
+00:27:53,590 --> 00:27:57,830
+اللغة العلمية .. اللغة العلمية ليست لغة قطية يا
+
+383
+00:27:57,830 --> 00:28:01,910
+بنات، لغة مشككة، ويجب أن نتعلم هذه اللغة، يجب أن
+
+384
+00:28:01,910 --> 00:28:05,330
+نتعلم هذه اللغة، الجبنة اللي بعدها على طول بتقول
+
+385
+00:28:12,050 --> 00:28:15,650
+مرتبط يعني لما بنلاقي percates lymphoma بنهزل منها
+
+386
+00:28:15,650 --> 00:28:21,990
+هذا الفيروس لكن لحد الآن مش واصلين لconclusive ل
+
+387
+00:28:21,990 --> 00:28:26,610
+cause and effect انه نقول ابشتين بار فيروس is the
+
+388
+00:28:26,610 --> 00:28:29,950
+cause of percates lymphoma خايفين يكون في عوامل
+
+389
+00:28:29,950 --> 00:28:34,990
+أخرى احنا لسه ماتكشفنهاش فهذا ما قصدته من اللغة
+
+390
+00:28:34,990 --> 00:28:40,470
+العلمية الغير قطية لأنه إذا قطعنابالـ cause and
+
+391
+00:28:40,470 --> 00:28:44,290
+effect أنا وقفت أي نوع من ال research بهذا الشأن
+
+392
+00:28:44,290 --> 00:28:48,070
+لأ خلي الناس تبحث و تتأكد من هذا الأمر إذا
+
+393
+00:28:48,070 --> 00:28:53,810
+البركسلينفومة و أنازو فارنجل كارسينوما فيروس واحد
+
+394
+00:28:53,810 --> 00:28:57,410
+اسمه بشتين بار فيروس ال human herbs type A
+
+395
+00:28:57,410 --> 00:29:00,470
+يبنالكوا سبب اللي هو كبوس الساركومة اللي لما ندرس
+
+396
+00:29:00,470 --> 00:29:05,160
+ال aids ان شاء الله هنطلع عليها بشكل جيدSeveral
+
+397
+00:29:05,160 --> 00:29:09,520
+herpes virus causes cancer in animals كثير من ال
+
+398
+00:29:09,520 --> 00:29:14,260
+herpes virus بتسبب سرطانات في الحيوانات مثلا
+
+399
+00:29:14,260 --> 00:29:20,360
+leukemia في القرود تمام و lymphomatosis في الدواجن
+
+400
+00:29:20,360 --> 00:29:25,380
+اذا ايضا الحيوانات بيصير فيها cancer و قد يكون سبب
+
+401
+00:29:25,380 --> 00:29:31,260
+هذا ال cancer هو ال ال ال الالـ biases كمان مرة
+
+402
+00:29:31,260 --> 00:29:35,060
+انا عملت محاضرة قبل فترة في يوم دراسي للسرطان في
+
+403
+00:29:35,060 --> 00:29:41,720
+الجامعة واتحدثت فيه عن مسببات السرطان الميكروبية
+
+404
+00:29:41,720 --> 00:29:48,240
+وحصلنا على معلومات يعني تفيد انه السرطان ممكن
+
+405
+00:29:48,240 --> 00:29:53,230
+ينتقل لحالهالسرطان نفسه ينتقل، احنا نعرف ان
+
+406
+00:29:53,230 --> 00:29:57,230
+السرطان غير موادي، السرطان غير موادي، لكن في
+
+407
+00:29:57,230 --> 00:30:01,790
+evidence بدأت تظهر معانا ان هناك بعض أنواع من
+
+408
+00:30:01,790 --> 00:30:04,330
+السرطان في الحيوانات، بعض أنواع من السرطان في
+
+409
+00:30:04,330 --> 00:30:08,310
+الحيوانات قد تنتقل من حيوان إلى حيوان، دون ما
+
+410
+00:30:08,310 --> 00:30:13,210
+انتقال المسبب اللي هو الفيروس، أمام؟فيه كمان حكينا
+
+411
+00:30:13,210 --> 00:30:20,110
+عن ساطان مثلا لحيوان اسمه تزمانيا ديفل شيطان
+
+412
+00:30:20,110 --> 00:30:25,530
+تزمانيا شيطان تزمانيا حيوان صغير هيك يشبه الكلب من
+
+413
+00:30:25,530 --> 00:30:28,710
+الجرابيات تعرفش الجرابيات اللي هي زي الكنغر اللي
+
+414
+00:30:28,710 --> 00:30:34,610
+بتحط الموضوع تبعها في الكيس هذا الحيوان شبه يعني
+
+415
+00:30:34,610 --> 00:30:38,770
+جبل بينقرض في مناطق في أستراليا في تزمانيا في
+
+416
+00:30:38,770 --> 00:30:43,890
+أستراليالجوا ان الكلاب لما بتلعب مع بعضها مية
+
+417
+00:30:43,890 --> 00:30:50,370
+بتلعب بالعض برضه وللا ففي فيروس بينتقل من المصاب
+
+418
+00:30:50,370 --> 00:30:54,450
+إلى السليم وبيحدثله سرطانات ففي سرطانات في
+
+419
+00:30:54,450 --> 00:30:58,450
+الحيوانات موجودة وموجودة بكثرة وهنا شايفين ان احنا
+
+420
+00:30:58,450 --> 00:31:04,770
+لكيميا in monkeys و lymphomatosis in chicken طيب
+
+421
+00:31:04,770 --> 00:31:10,650
+نيجيلا اولعضوين في المجموعة اللي هما Herbal
+
+422
+00:31:10,650 --> 00:31:15,190
+Simplex Type I و Type II هل هناك فروقات بين اتنين
+
+423
+00:31:15,190 --> 00:31:21,210
+بشكل بالتركيب؟ لا يوجد الا بالـ Antigenicity يعني
+
+424
+00:31:21,210 --> 00:31:24,770
+كل واحد فيهم له Antigenات مختلفة عن الآخر رقم
+
+425
+00:31:24,770 --> 00:31:29,450
+اتنين ال location of lesions above the waist و
+
+426
+00:31:29,450 --> 00:31:34,620
+below the waist زي ما ذكرنا في السابقوهذه يمكن
+
+427
+00:31:34,620 --> 00:31:37,860
+اللوحات بتوضح لنا الفروقات الأهم بين الاتنين
+
+428
+00:31:37,860 --> 00:31:43,080
+اطلعوني على الـ Central Nervous System
+
+429
+00:31:43,080 --> 00:31:46,640
+Complications الأولى بيقول عنها Encephalitis
+
+430
+00:31:46,640 --> 00:31:52,960
+والتانية Meningitisالـ Neonates غالبا لا تصاب على
+
+431
+00:31:52,960 --> 00:31:57,020
+الرغم من أن طريقة الانتقال الـ Herpes Simplex Type
+
+432
+00:31:57,020 --> 00:32:02,980
+I للأطفال غالبا بتتم من الكبار عبر التقبيل يعني
+
+433
+00:32:02,980 --> 00:32:06,920
+واحد بيكون مصاب بـ Herpes Simplex Type I و بيقبل
+
+434
+00:32:06,920 --> 00:32:12,940
+الطفل فبينقله الفيروس بينما الـ Herpes Simplex
+
+435
+00:32:12,940 --> 00:32:16,040
+Type II بينتقل عن طريق أب مروره عبر قناعة جنة
+
+436
+00:32:16,040 --> 00:32:21,960
+الولادةالـ I نعم type 1 بسبب keratoconjectivitis
+
+437
+00:32:21,960 --> 00:32:26,380
+وهي condition صعب يعني الأصل أنه يكون يلو عناية
+
+438
+00:32:26,380 --> 00:32:32,180
+خاصة هذا المرض بينما في ال type 2 مافيش أنه هذه
+
+439
+00:32:32,180 --> 00:32:35,860
+المشكلة ال mouth طبعا في الفم ممكن يكون
+
+440
+00:32:35,860 --> 00:32:39,560
+gingivostomatitis يعني في الفم فيه rashes لأ type
+
+441
+00:32:39,560 --> 00:32:45,220
+1 لكن type 2 مافيش rashes الجملة الأولى اللي هي
+
+442
+00:32:45,220 --> 00:32:49,880
+قلنا above the waist و below the waistالتكرار اللي
+
+443
+00:32:49,880 --> 00:32:54,720
+ما ذكرناه acute gingivostomatitis recurrent herpes
+
+444
+00:32:54,720 --> 00:32:59,800
+labialis اللي احنا بنسميها تقرحات البرد يعني لما
+
+445
+00:32:59,800 --> 00:33:04,340
+واحد بيكون عنده حمةأو بيسموها fever blisters لو
+
+446
+00:33:04,340 --> 00:33:08,140
+يكون عنده حمة و بيطلع على الحم هذا الخارجي الحم
+
+447
+00:33:08,140 --> 00:33:12,120
+الخارجي هذا إذا حد طلعله يعرف أن هو عنده herpes
+
+448
+00:33:12,120 --> 00:33:18,080
+simplex type 1 وهذا سيبقى معه إلى الأبد يعني هيموت
+
+449
+00:33:18,080 --> 00:33:23,080
+معك تمام؟ هذا صديق اللي مشبر .. احنا مشبرين عليه
+
+450
+00:33:23,080 --> 00:33:28,920
+ليش مشبرين عليه؟ لأن حتى لما بيخف بيروح هو بيروحش
+
+451
+00:33:30,230 --> 00:33:36,510
+مختفي كامن و احنا في الطب ليس لدينا اي تقنيات او
+
+452
+00:33:36,510 --> 00:33:43,670
+اي مهارات في بنعالج بنمنع حدوث لكن لا نستطيع اخراج
+
+453
+00:33:43,670 --> 00:33:49,250
+حالة الكمون من جسم الإنسان اذا فيروس كامن ليس
+
+454
+00:33:49,250 --> 00:33:53,230
+لدينا في الوقت الراهن اي امكانية لاخراج هذا او
+
+455
+00:33:53,230 --> 00:33:57,890
+تخلص من هذا الكمون keratoconjectivitis and
+
+456
+00:33:57,890 --> 00:34:01,630
+encephalitisالـ Herpes Simplex Type 2 تلاتة
+
+457
+00:34:01,630 --> 00:34:05,710
+مشهورين فيهم Genital Herpes وNeonatal Herpes
+
+458
+00:34:05,710 --> 00:34:09,550
+وAseptic Meningitis ككمبليكيشن اللي ذكرناها قبل
+
+459
+00:34:09,550 --> 00:34:18,010
+قليل كمان
+
+460
+00:34:18,010 --> 00:34:22,170
+شغل بتساعدنا في التفريق بينهم حاجة مع Restriction
+
+461
+00:34:22,170 --> 00:34:26,960
+Endonucleases ايش يعني Endonucleases؟اللي هي
+
+462
+00:34:26,960 --> 00:34:31,340
+restriction enzymes اللي بتقطع ال DNA مظبوط وانتوا
+
+463
+00:34:31,340 --> 00:34:35,400
+عارفين انه كل restriction enzyme له site محدد،
+
+464
+00:34:35,400 --> 00:34:41,820
+sequence محدد بيقطع عنده تخيلوا جبنا أربع دفعات من
+
+465
+00:34:41,820 --> 00:34:45,760
+نفس النوع من البكتيريا أربع دفعات من نفس النوع من
+
+466
+00:34:45,760 --> 00:34:48,840
+البكتيريا أخدنا ال genome تبعها، أخدنا ال genome
+
+467
+00:34:48,840 --> 00:34:53,650
+تبعها، أخدنا ال genome تبعهاوحطينا عليهم نفس
+
+468
+00:34:53,650 --> 00:34:56,990
+الأنواع ونفس العدد من مين من ال restriction enzyme
+
+469
+00:34:56,990 --> 00:35:02,390
+ودخلناهم gel electrophoresis يهل ترى القطع تبعاتهم
+
+470
+00:35:02,390 --> 00:35:06,030
+هتختلف ال pattern النمط تبعهم هيختلف ولا هيكون نفس
+
+471
+00:35:06,030 --> 00:35:10,010
+النمط هيكون نفس النمط لإن أنا استخدمت نفس المادة
+
+472
+00:35:10,010 --> 00:35:14,570
+الوراثية ونفس ال restriction enzyme حالة بسميها
+
+473
+00:35:14,570 --> 00:35:17,810
+finger printing بس مش finger printing بصمات أصابع
+
+474
+00:35:17,810 --> 00:35:23,320
+بسميها DNA finger printingنستطيع من خلال
+
+475
+00:35:23,320 --> 00:35:26,860
+Restriction in the Nucleus ايضا نميز بين Herpes
+
+476
+00:35:26,860 --> 00:35:31,220
+Type I وHerpes Type II وكمان ذكرنا في اللوحات
+
+477
+00:35:31,220 --> 00:35:34,900
+السابقة انه ممكن نميزهم من خلال الـ Antigenicity
+
+478
+00:35:34,900 --> 00:35:40,960
+باستخدام Monoclonal Antibodiesعلى الرغم من ان
+
+479
+00:35:40,960 --> 00:35:45,280
+المعلومة المفروضة انها تكون مهمة الا ان قدرة
+
+480
+00:35:45,280 --> 00:35:48,620
+الميكروب على الكمون تجعل ان هذه المعلومة غير مهمة
+
+481
+00:35:48,620 --> 00:35:53,320
+ان ال humans are the only natural host for اللي هو
+
+482
+00:35:53,320 --> 00:35:57,180
+ال herpes simplex type 1 and type 2 لو في
+
+483
+00:35:57,180 --> 00:36:01,260
+البكتيريا إذا علشنا البناء أدمين المصابين
+
+484
+00:36:01,260 --> 00:36:08,460
+بالبكتيريا بنكون خلصنا على المرض من كوكب الأرضفي
+
+485
+00:36:08,460 --> 00:36:11,540
+الفيروسات اللي بتاعمل latency انا بعالجهم بس بقدر
+
+486
+00:36:11,540 --> 00:36:16,120
+اخلص ال latency بقدرش وحنشوف في ال CMV انه قلتلكوا
+
+487
+00:36:16,120 --> 00:36:18,920
+اكتر من مرة في ال CMV في عندي حاجة اسمها
+
+488
+00:36:18,920 --> 00:36:24,240
+asymptomatic shedding يعني الشخص ليس لديه اي اعراض
+
+489
+00:36:24,240 --> 00:36:29,340
+لكن ماشي وبينشر من ال CMVأنا كنا زمان نقول
+
+490
+00:36:29,340 --> 00:36:32,300
+البكتيريا أنجحة المخلوقات، مين أنجح المخلوقات؟
+
+491
+00:36:32,300 --> 00:36:36,220
+الفيروسات، مين أكثر المخلوقات عالمية على كوكب
+
+492
+00:36:36,220 --> 00:36:40,240
+الأرض؟ الفيروسات، هم هم تخيلوا، و بيقولوا إنها
+
+493
+00:36:40,240 --> 00:36:42,880
+الأدنى في السلسلة، مين الأدنى في السلسلة؟ طلعنا
+
+494
+00:36:42,880 --> 00:36:45,860
+أحنا، قولنا لا، احنا أجال .. أجال من الصراصير اللي
+
+495
+00:36:45,860 --> 00:36:50,730
+موجودة في ال ..أنتوا عارفين في مقولة على موضوع
+
+496
+00:36:50,730 --> 00:36:54,990
+الحشرات، الحشرات من أنجح المخلوقات أيضا في البقاء،
+
+497
+00:36:54,990 --> 00:36:59,410
+وأحد العلماء بيقول إن أردت أن يعني تبقى حيا لفترة
+
+498
+00:36:59,410 --> 00:37:02,830
+طويلة فاختبئ داخل حشرة، اختبئ داخل حشرة، دلالة على
+
+499
+00:37:02,830 --> 00:37:06,430
+أن الحشرات لديها المقدرة أنتوا بتشوفوها في البيوت
+
+500
+00:37:07,270 --> 00:37:10,390
+النظيفة و المرتبة و كل إشي كراميكا و جزاز و كده و
+
+501
+00:37:10,390 --> 00:37:14,390
+مالك إلا اللي لاجي حشرات جاية عندها في البيت فهي
+
+502
+00:37:14,390 --> 00:37:18,930
+عندها المقدر عليها تعيش بشكل يعني ملفت لنظر
+
+503
+00:37:18,930 --> 00:37:22,570
+الصحيحة
+
+504
+00:37:22,570 --> 00:37:26,710
+HSV-1 is transmitted primarily in saliva عن طريق
+
+505
+00:37:26,710 --> 00:37:31,770
+اللعاب و هناك تقبيل أحد الطرق بينما ال
+
+506
+00:37:31,770 --> 00:37:34,510
+herpesimplex type 2 بينتقل mainly عن طريق ال
+
+507
+00:37:34,510 --> 00:37:35,770
+sexual contact
+
+508
+00:37:38,910 --> 00:37:43,690
+و لهذا السبب بنلاقي انه العراع تبعت ال herpes
+
+509
+00:37:43,690 --> 00:37:48,470
+simplex type 1 في ال face بينما ال herpes simplex
+
+510
+00:37:48,470 --> 00:37:51,470
+type 2 بتكون بلوغ انها دواس في ال genital area
+
+511
+00:37:51,470 --> 00:37:55,530
+الحين
+
+512
+00:37:55,530 --> 00:37:59,350
+احنا مفترض مفترضين ان انا في عندي vesicle صح؟ ال
+
+513
+00:37:59,350 --> 00:38:04,310
+vesicle ها دي مغطية لسه السائل اللي جواها ماطلعش
+
+514
+00:38:04,310 --> 00:38:10,600
+برا تمام؟ لو انفجرتجزء كبير من الفيروس اللى موجود
+
+515
+00:38:10,600 --> 00:38:14,920
+جوا هيصير موجود في هذا السائل، لو هذا السائل لمس
+
+516
+00:38:14,920 --> 00:38:19,420
+اي شخص اخر اكيد هيكون infectious هذا امر مفروض
+
+517
+00:38:19,420 --> 00:38:25,860
+منه، المشكلة وين؟ اذا مافيش physicals يهل ترى هل
+
+518
+00:38:25,860 --> 00:38:28,820
+الإنسان بينتج الفيروس و لا بينتج الفيروس؟
+
+519
+00:38:31,060 --> 00:38:36,080
+في معظم حالات الـ syphilis الجنسي أو اللاجنسي اللي
+
+520
+00:38:36,080 --> 00:38:39,320
+هو الـ herpes syphilis type 1 ورد أن الإنسان اللي
+
+521
+00:38:39,320 --> 00:38:43,860
+ماعندوش عرض كان شد، شد يعني بينتج أو بيفرز أو
+
+522
+00:38:43,860 --> 00:38:48,100
+بيرمي بيروسات وإن كان عادية قليل، لكن في الحالتين
+
+523
+00:38:48,100 --> 00:38:51,020
+ممكن يكون معدى، في الحالتين ممكن يكون معدى، يعني
+
+524
+00:38:51,020 --> 00:38:54,180
+في حالة الـ active وفي حالة الـ non-active
+
+525
+00:38:57,680 --> 00:39:02,040
+ال HSV2 طبعا في أوروبا و دولة المتحدة ازداد في
+
+526
+00:39:02,040 --> 00:39:05,960
+السنوات الأخيرة و أي مرض جنسي اصلا بيزداد و خليني
+
+527
+00:39:05,960 --> 00:39:11,640
+انا اقف يعني لحظة عن الامراض الجنسيةالأمراض
+
+528
+00:39:11,640 --> 00:39:15,500
+الجنسية المنتقلة عن طريق الجنس منتشرة بشكل كبير في
+
+529
+00:39:15,500 --> 00:39:19,900
+أوروبا وأمريكا وفي كل العالم اللاديني تمام؟
+
+530
+00:39:19,900 --> 00:39:23,420
+والغربي حتى في البلدان اللي فيها انحلال خلقي من
+
+531
+00:39:23,420 --> 00:39:27,380
+البلدان الإسلامية أيضا الأمراض الجنسية منتشرة فيها
+
+532
+00:39:27,380 --> 00:39:33,080
+بكثرة والجميع يعلم أن ممارسة الجنس خارج علاقة
+
+533
+00:39:33,080 --> 00:39:38,020
+زوجية طبيعية هي السبب الرئيسي الا انهشيطانهم
+
+534
+00:39:38,020 --> 00:39:42,440
+يخبرهم بإنهم ينتقلوا إعبارات لطيفة مثل practice
+
+535
+00:39:42,440 --> 00:39:46,350
+safe sexيعني استخدم الواقي مثلا للممارسة الجنسية
+
+536
+00:39:46,350 --> 00:39:51,610
+ولكن لازم تتنوع عن الممارسة الجنسية للأسف هذا هو
+
+537
+00:39:51,610 --> 00:39:56,850
+الموجه الرئيسي لازدياد حالات الأمراض الجنسية ما
+
+538
+00:39:56,850 --> 00:40:02,210
+زالت الجنورية مسيطرة ما زالت الكلاميديا مسيطرة ال
+
+539
+00:40:02,210 --> 00:40:07,090
+HIV مسيطرة ال syphilis مسيطرة وان ال herpes
+
+540
+00:40:07,090 --> 00:40:13,760
+genitalis أيضا مسيطرةفنسبة كبيرة من الناس في
+
+541
+00:40:13,760 --> 00:40:18,560
+أوروبا أو أمريكا أو العالم اللاديني غالبا مصابين
+
+542
+00:40:18,560 --> 00:40:23,700
+بأمراض جنسية كثيرة فلما نسمع إنه فيه ازدياد في
+
+543
+00:40:23,700 --> 00:40:30,780
+الحالات الأمراض الجنسية أمر غير مستغرب 80% of
+
+544
+00:40:30,780 --> 00:40:35,260
+people في الولايات المتحدة are infected with HSV-1
+
+545
+00:40:35,260 --> 00:40:43,330
+HSV-1 مش مرض جنسيلكن 80% منهم مصابين فيهالان 40%
+
+546
+00:40:43,330 --> 00:40:47,590
+من الناس المصابي من 80% بيصير انهم reactivation at
+
+547
+00:40:47,590 --> 00:40:51,110
+least once in their lifetime كلمة reactivation انا
+
+548
+00:40:51,110 --> 00:40:52,990
+اعتقد انكوا شوفتوا ايش هنا reactivation في ال
+
+549
+00:40:52,990 --> 00:40:56,730
+herpes simplex type ولا حاجة بليستر صح؟ اللي هي
+
+550
+00:40:56,730 --> 00:41:00,230
+الحب اللي تطلعتناها أو الحم اللي طلعتناها وانتهى
+
+551
+00:41:00,230 --> 00:41:05,010
+الموضوع لكن في الجنسي قد يصل إلى جنة meningitis
+
+552
+00:41:05,010 --> 00:41:07,570
+وخاصة by repeated infection
+
+553
+00:41:09,820 --> 00:41:12,220
+طبعا حالات ال .. ال .. ال .. ال .. ال herpes
+
+554
+00:41:12,220 --> 00:41:16,160
+simplex type 1 غالبا تحدث في سن مبكرة عند الأطفال
+
+555
+00:41:16,160 --> 00:41:19,440
+بينما ال herpes simplex type 2 لأنه بينتقل عن طريق
+
+556
+00:41:19,440 --> 00:41:22,140
+ال genes فبيكون عند اللي هو مرحلة البلو
+
+557
+00:41:25,740 --> 00:41:29,560
+تقريبا يمكن اللي لو حد حكيناها، لكن اللي تنسي ..
+
+558
+00:41:29,560 --> 00:41:32,860
+اللي تنسي .. مين اللي بيخل .. بيعمله triggering،
+
+559
+00:41:32,860 --> 00:41:38,600
+triggering يعني يصحيه من النوم، هو الآن كامن ..
+
+560
+00:41:38,600 --> 00:41:45,160
+كامن و غير نشطولا يعبّر عن نفسه ما هي الأحوال التي
+
+561
+00:41:45,160 --> 00:41:50,580
+يمكن لها أن تستثير هذا الفيروس للـ reactivation
+
+562
+00:41:50,580 --> 00:41:55,880
+واحد Sunlight اتعرض للشمس الحارقة لفترة طويلة
+
+563
+00:41:55,880 --> 00:41:59,460
+اتنين و هذا على فكرة بيؤدي للجفاف وحتى لو ما
+
+564
+00:41:59,460 --> 00:42:04,080
+اتعرضناش للشمس الحارقة وصار فيه جفاف تمام؟ يعني
+
+565
+00:42:04,080 --> 00:42:08,340
+مثلافي مرحلة الصيام في رمضان وكان الإنسان نشط
+
+566
+00:42:08,340 --> 00:42:13,520
+لفترة طويلة و قطش كتير جف الحلق طبعه و شفاف قد
+
+567
+00:42:13,520 --> 00:42:17,840
+يظهر ocelo activation تمام؟ hormonal changes
+
+568
+00:42:17,840 --> 00:42:22,740
+تغيرات هرمونية في فترة الدورة الشهرية أو في انتقال
+
+569
+00:42:22,740 --> 00:42:29,460
+من سن الطفولة إلى سن البلوغ أو سن اليأس يعني أي
+
+570
+00:42:29,460 --> 00:42:33,620
+hormonal changes ممكن تؤدي لهذا الموضوع trauma خطأ
+
+571
+00:42:36,420 --> 00:42:40,780
+Stress، توتر، انتحان، quiz، الهاتف ليس لديه
+
+572
+00:42:40,780 --> 00:42:48,500
+إنترنت، Unfever، الحُمّة، أيضًا عامل مهم جدًا من
+
+573
+00:42:48,500 --> 00:42:51,860
+العوامل اللي ممكن تعمل triggering لل reactivation
+
+574
+00:42:53,930 --> 00:43:00,550
+ال immunity غالبا بيسموها type specific يعني إذا
+
+575
+00:43:00,550 --> 00:43:04,370
+أخدنا فيرس واحد هشيل أنها immunity لمين؟ لفيرس
+
+576
+00:43:04,370 --> 00:43:09,770
+واحد إذا أخدنا اتنين هشيل أنها لاتنين لكن يوجد
+
+577
+00:43:09,770 --> 00:43:15,420
+somehow cross protected يعني خدنا نقولجزء من ال
+
+578
+00:43:15,420 --> 00:43:18,740
+cross-protectivity يعني إذا انصاب واحد بيحميه
+
+579
+00:43:18,740 --> 00:43:24,240
+جزئيا ولكن ليس كليا من النوع التانية سمناها some
+
+580
+00:43:24,240 --> 00:43:29,160
+cross-protection existالـ Cell-mediated immunity
+
+581
+00:43:29,160 --> 00:43:34,180
+هي الأهم على الإطلاق في حال الـ Herpes virus سميلي
+
+582
+00:43:34,180 --> 00:43:37,560
+و كيف عرفنا إنها الأهم على الإطلاق؟ لما عملنا لها
+
+583
+00:43:37,560 --> 00:43:40,840
+suppression للـ Cell-mediated immunity صار فينا
+
+584
+00:43:40,840 --> 00:43:44,960
+severe cases of Herpes Simplex type 1 and type 2
+
+585
+00:43:44,960 --> 00:43:48,140
+المرة الجاية إن شاء الله بنكمل مع هذه الفيروسات
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/dIVF2sBm1zc_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/dIVF2sBm1zc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..b9c889e556557c11146114a1175cabbb041c5494
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/dIVF2sBm1zc_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3843, "start": 21.19, "end": 38.43, "text": "بسم الله الرحمن الرحيم اليوم موضوعنا ان شاء الله موضوع كتير مهم وبيشمل مجموعة من ال unrelated يعني لا لا تشترك في شيء الا انه ال main target تبعها هو ال liver وهي Hepatitis viruses", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 45595, 20498, 3714, 2407, 11242, 45367, 8315, 16472, 13412, 16606, 21984, 3714, 2407, 11242, 45367, 9122, 2655, 13546, 3714, 16095, 4032, 21292, 8592, 42213, 3714, 7435, 2304, 2407, 27884, 9154, 2423, 38967, 37495, 22653, 20193, 20193, 6055, 8592, 2655, 31747, 8978, 44049, 38207, 42963, 16472, 3224, 2423, 2135, 3779, 6055, 3555, 3615, 11296, 31439, 2423, 15019, 37037, 1829, 30578, 267, 16074, 21785], "avg_logprob": -0.14789496921002865, "compression_ratio": 1.5628415300546448, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 21.19, "end": 21.43, "word": "بسم", "probability": 0.822265625}, {"start": 21.43, "end": 21.57, "word": " الله", 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followed one three weeks later by the production of IgG antibodies، يعني ال IgG antibodies بيتبع ال IgM لكن بياخد فترة طويلة، which provides lifelong protection، إذا مين المسؤول عن الحماية المستقبلية هو ال IgG؟", "tokens": [1829, 39648, 36145, 2423, 39184, 8967, 295, 19271, 44, 307, 6263, 538, 34051, 6263, 472, 1045, 3259, 1780, 538, 264, 4265, 295, 19271, 38, 28356, 12399, 37495, 22653, 2423, 19271, 38, 28356, 4724, 36081, 3555, 3615, 2423, 19271, 44, 44381, 4724, 1829, 47283, 3215, 6156, 2655, 25720, 23032, 2407, 26895, 3660, 12399, 597, 6417, 27232, 6334, 12399, 11933, 15730, 3714, 9957, 9673, 3794, 33604, 12610, 18871, 21542, 15042, 10632, 9673, 14851, 4587, 36150, 10632, 31439, 2423, 19271, 38, 22807], "avg_logprob": -0.25312500521540643, "compression_ratio": 1.4549356223175967, "no_speech_prob": 0.0, "words": [{"start": 657.52, "end": 657.84, "word": "يقول", "probability": 0.48046875}, {"start": 657.84, "end": 658.0, "word": " إن", "probability": 0.1826171875}, {"start": 658.0, 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عدد كبير جدا طبعا فكروا فيها", "tokens": [2655, 1863, 4587, 1211, 9154, 36145, 3794, 7649, 30731, 36145, 3794, 7649, 11933, 15040, 6055, 30544, 3714, 5172, 3224, 2407, 9381, 3660, 24976, 39184, 30578, 267, 16074, 363, 3753, 2511, 3213, 46599, 2655, 6027, 1829, 23758, 16490, 5172, 11242, 6225, 3215, 3215, 33688, 9381, 16758, 9307, 30731, 6225, 3215, 3215, 12174, 20292, 1211, 10874, 28259, 37495, 22653, 11331, 49975, 30578, 267, 16074, 383, 7251, 43020, 8978, 32771, 11622, 3660, 20328, 9640, 2655, 5551, 3615, 23942, 9154, 30578, 267, 16074, 363, 37495, 22653, 16472, 9778, 5172, 11242, 18863, 3215, 3215, 30731, 20666, 5172, 30241, 6225, 3215, 3215, 9122, 3555, 13546, 10874, 28259, 23032, 3555, 3615, 995, 6156, 37983, 14407, 8978, 11296], "avg_logprob": -0.11986204968379424, "compression_ratio": 1.6846846846846846, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2274.81, "end": 2275.61, "word": "تنقل", "probability": 0.80108642578125}, {"start": 2275.61, "end": 2275.73, 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لأن هناك منافسة له في هذا المجال إذا افترضنا أن هناك بيمنع ال cancer و هنا بيمنع ال cancer فالثانين الآن بيمنعوا ال cancer it appears that", "tokens": [2407, 4587, 1211, 8315, 36145, 3224, 6225, 42213, 8315, 7007, 4032, 4587, 1211, 8315, 2423, 7007, 23758, 37495, 22653, 1970, 5592, 5296, 33456, 3224, 4724, 28259, 7251, 35571, 1829, 8315, 9154, 2423, 5752, 13672, 1829, 4724, 1829, 35457, 3555, 2423, 5592, 7251, 3555, 4587, 7578, 34105, 6225, 42213, 8315, 7007, 48812, 3215, 3714, 9957, 48812, 3215, 4386, 4032, 4386, 4032, 1975, 34268, 26890, 8315, 16472, 3224, 264, 700, 5296, 33456, 34105, 4117, 3714, 8315, 36178, 3660, 46740, 8978, 23758, 9673, 7435, 6027, 11933, 15730, 1975, 5172, 2655, 43042, 8315, 14739, 34105, 4117, 4724, 1829, 27842, 3615, 2423, 5592, 4032, 34105, 4724, 1829, 27842, 3615, 2423, 5592, 6156, 6027, 12984, 7649, 9957, 6024, 48506, 4724, 1829, 27842, 3615, 14407, 2423, 5592, 309, 7038, 300], "avg_logprob": -0.2598286177362165, "compression_ratio": 2.008298755186722, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2673.94, "end": 2674.38, "word": "وقلنا", "probability": 0.71710205078125}, {"start": 2674.38, "end": 2674.64, "word": " إنه", "probability": 0.6837158203125}, {"start": 2674.64, "end": 2674.94, "word": " عملنا", "probability": 0.9752604166666666}, {"start": 2674.94, "end": 2675.36, "word": " vaccine", "probability": 0.40966796875}, {"start": 2675.36, "end": 2675.84, "word": " وقلنا", "probability": 0.87841796875}, {"start": 2675.84, "end": 2675.96, "word": " ال", "probability": 0.5693359375}, {"start": 2675.96, "end": 2676.24, "word": " vaccine", "probability": 0.95458984375}, {"start": 2676.24, "end": 2676.7, "word": " هذا", "probability": 0.78759765625}, {"start": 2676.7, "end": 2677.8, "word": " يعني", "probability": 0.6209716796875}, {"start": 2677.8, "end": 2678.56, "word": " against", "probability": 0.93408203125}, {"start": 2678.56, "end": 2679.1, "word": " cancer", "probability": 0.81689453125}, {"start": 2679.1, "end": 2680.08, "word": " لأنه", "probability": 0.7972005208333334}, {"start": 2680.08, "end": 2680.24, "word": " بدا", "probability": 0.7578125}, {"start": 2680.24, "end": 2680.68, "word": " يحمينا", "probability": 0.79400634765625}, {"start": 2680.68, "end": 2680.84, "word": " من", "probability": 0.986328125}, {"start": 2680.84, "end": 2681.08, "word": " ال", "probability": 0.89404296875}, {"start": 2681.08, "end": 2681.54, "word": " virus", "probability": 0.97021484375}, {"start": 2681.54, "end": 2682.06, "word": " اللي", "probability": 0.939697265625}, {"start": 2682.06, "end": 2682.44, "word": " بيسبب", "probability": 0.9273681640625}, {"start": 2682.44, "end": 2682.54, "word": " ال", "probability": 0.86669921875}, {"start": 2682.54, "end": 2682.94, "word": " cancer", "probability": 0.9453125}, {"start": 2682.94, "end": 2683.24, "word": " يبقى", "probability": 0.579345703125}, {"start": 2683.24, "end": 2683.42, "word": " هنا", "probability": 0.83203125}, {"start": 2683.42, "end": 2684.26, "word": " عملنا", "probability": 0.9934895833333334}, {"start": 2684.26, "end": 2684.72, "word": " vaccine", "probability": 0.9814453125}, {"start": 2684.72, "end": 2684.94, "word": " ضد", "probability": 0.997314453125}, {"start": 2684.94, "end": 2685.2, "word": " مين", "probability": 0.92626953125}, {"start": 2685.2, "end": 2685.48, "word": " ضد", "probability": 0.824951171875}, {"start": 2685.48, "end": 2685.72, "word": " ..", "probability": 0.399169921875}, {"start": 2685.72, "end": 2686.08, "word": " و", "probability": 0.83642578125}, {"start": 2686.08, "end": 2686.24, "word": " ..", "probability": 0.546875}, {"start": 2686.24, "end": 2686.36, "word": " و", "probability": 0.92626953125}, {"start": 2686.36, "end": 2686.74, "word": " اعتبرنا", "probability": 0.7403564453125}, {"start": 2686.74, "end": 2687.02, "word": " انه", "probability": 0.774169921875}, {"start": 2687.02, "end": 2687.22, "word": " the", "probability": 0.6484375}, {"start": 2687.22, "end": 2687.52, "word": " first", "probability": 0.9296875}, {"start": 2687.52, "end": 2688.14, "word": " لأن", "probability": 0.2923583984375}, {"start": 2688.14, "end": 2689.02, "word": " هناك", "probability": 0.9755859375}, {"start": 2689.02, "end": 2689.58, "word": " منافسة", "probability": 0.81768798828125}, {"start": 2689.58, "end": 2689.8, "word": " له", "probability": 0.87255859375}, {"start": 2689.8, "end": 2690.22, "word": " في", "probability": 0.98779296875}, {"start": 2690.22, "end": 2690.44, "word": " هذا", "probability": 0.97412109375}, {"start": 2690.44, "end": 2690.96, "word": " المجال", "probability": 0.9944661458333334}, {"start": 2690.96, "end": 2691.38, "word": " إذا", "probability": 0.887451171875}, {"start": 2691.38, "end": 2691.76, "word": " افترضنا", "probability": 0.8978515625}, {"start": 2691.76, "end": 2691.88, "word": " أن", "probability": 0.38427734375}, {"start": 2691.88, "end": 2692.16, "word": " هناك", "probability": 0.7030029296875}, {"start": 2692.16, "end": 2692.64, "word": " بيمنع", "probability": 0.83758544921875}, {"start": 2692.64, "end": 2692.92, "word": " ال", "probability": 0.951171875}, {"start": 2692.92, "end": 2693.32, "word": " cancer", "probability": 0.95361328125}, {"start": 2693.32, "end": 2694.2, "word": " و", "probability": 0.66552734375}, {"start": 2694.2, "end": 2694.38, "word": " هنا", "probability": 0.5263671875}, {"start": 2694.38, "end": 2695.0, "word": " بيمنع", "probability": 0.858642578125}, {"start": 2695.0, "end": 2695.22, "word": " ال", "probability": 0.982421875}, {"start": 2695.22, "end": 2695.66, "word": " cancer", "probability": 0.97900390625}, {"start": 2695.66, "end": 2696.12, "word": " فالثانين", "probability": 0.75966796875}, {"start": 2696.12, "end": 2696.4, "word": " الآن", "probability": 0.6678466796875}, {"start": 2696.4, "end": 2696.92, "word": " بيمنعوا", "probability": 0.87802734375}, {"start": 2696.92, "end": 2697.1, "word": " ال", "probability": 0.96484375}, {"start": 2697.1, "end": 2697.4, "word": " cancer", "probability": 0.97802734375}, {"start": 2697.4, "end": 2697.8, "word": " it", "probability": 0.61376953125}, {"start": 2697.8, "end": 2698.06, "word": " appears", "probability": 0.5087890625}, {"start": 2698.06, "end": 2698.36, "word": " that", "probability": 0.953125}], "temperature": 1.0}, {"id": 118, "seek": 271906, "start": 2698.5, "end": 2719.06, "text": "HPV vaccine is the first vaccine to prevent a human cancer والحقيقة ان ال HPV هذا HP هذا HPV vaccine كان قبل اللي هو ال human papilloma virus vaccine المرة الجاية ان شاء الله بنكمل ال pathogens و ال immunity و باقي الفيروس", "tokens": [39, 47, 53, 7007, 307, 264, 700, 7007, 281, 4871, 257, 1952, 5592, 16070, 5016, 38436, 28671, 16472, 2423, 12557, 53, 23758, 12557, 23758, 12557, 53, 7007, 25961, 12174, 36150, 13672, 1829, 31439, 2423, 1952, 5806, 373, 6440, 5752, 7007, 9673, 25720, 25724, 995, 10632, 16472, 13412, 16606, 21984, 44945, 24793, 1211, 2423, 44760, 4032, 2423, 22701, 4032, 4724, 995, 38436, 27188, 13546, 41779], "avg_logprob": -0.27379807692307695, "compression_ratio": 1.5336787564766838, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 2698.5, "end": 2699.42, "word": "HPV", "probability": 0.7340494791666666}, {"start": 2699.42, "end": 2699.9, "word": " vaccine", "probability": 0.382568359375}, {"start": 2699.9, "end": 2700.64, "word": " is", "probability": 0.8798828125}, {"start": 2700.64, "end": 2700.82, "word": " the", "probability": 0.9140625}, {"start": 2700.82, "end": 2701.2, "word": " first", "probability": 0.890625}, {"start": 2701.2, "end": 2701.8, "word": " vaccine", "probability": 0.96044921875}, {"start": 2701.8, "end": 2702.18, "word": " to", "probability": 0.95068359375}, {"start": 2702.18, "end": 2702.58, "word": " prevent", "probability": 0.84228515625}, {"start": 2702.58, "end": 2702.74, "word": " a", "probability": 0.81005859375}, {"start": 2702.74, "end": 2703.0, "word": " human", "probability": 0.91650390625}, {"start": 2703.0, "end": 2703.64, "word": " cancer", "probability": 0.9677734375}, {"start": 2703.64, "end": 2704.38, "word": " والحقيقة", "probability": 0.848388671875}, {"start": 2704.38, "end": 2704.52, "word": " ان", "probability": 0.397705078125}, {"start": 2704.52, "end": 2704.62, "word": " ال", "probability": 0.86865234375}, {"start": 2704.62, "end": 2706.46, "word": " HPV", "probability": 0.89794921875}, {"start": 2706.46, "end": 2706.7, "word": " هذا", "probability": 0.301513671875}, {"start": 2706.7, "end": 2708.22, "word": " HP", "probability": 0.345458984375}, {"start": 2708.22, "end": 2709.08, "word": " هذا", "probability": 0.2529296875}, {"start": 2709.08, "end": 2710.24, "word": " HPV", "probability": 0.852294921875}, {"start": 2710.24, "end": 2711.82, "word": " vaccine", "probability": 0.43603515625}, {"start": 2711.82, "end": 2712.12, "word": " كان", "probability": 0.9443359375}, {"start": 2712.12, "end": 2712.46, "word": " قبل", "probability": 0.9775390625}, {"start": 2712.46, "end": 2712.6, "word": " اللي", "probability": 0.8681640625}, {"start": 2712.6, "end": 2712.78, "word": " هو", "probability": 0.93310546875}, {"start": 2712.78, "end": 2712.92, "word": " ال", "probability": 0.76708984375}, {"start": 2712.92, "end": 2713.1, "word": " human", "probability": 0.81787109375}, {"start": 2713.1, "end": 2713.64, "word": " papilloma", "probability": 0.9708658854166666}, {"start": 2713.64, "end": 2714.42, "word": " virus", "probability": 0.9375}, {"start": 2714.42, "end": 2714.88, "word": " vaccine", "probability": 0.892578125}, {"start": 2714.88, "end": 2715.32, "word": " المرة", "probability": 0.781494140625}, {"start": 2715.32, "end": 2715.46, "word": " الجاية", "probability": 0.6023763020833334}, {"start": 2715.46, "end": 2715.56, "word": " ان", "probability": 0.71875}, {"start": 2715.56, "end": 2715.7, "word": " شاء", "probability": 0.90869140625}, {"start": 2715.7, "end": 2715.74, "word": " الله", "probability": 0.962890625}, {"start": 2715.74, "end": 2716.66, "word": " بنكمل", "probability": 0.9488932291666666}, {"start": 2716.66, "end": 2717.14, "word": " ال", "probability": 0.8720703125}, {"start": 2717.14, "end": 2717.38, "word": " pathogens", "probability": 0.42578125}, {"start": 2717.38, "end": 2717.66, "word": " و", "probability": 0.65576171875}, {"start": 2717.66, "end": 2717.7, "word": " ال", "probability": 0.9638671875}, {"start": 2717.7, "end": 2717.94, "word": " immunity", "probability": 0.89697265625}, {"start": 2717.94, "end": 2718.1, "word": " و", "probability": 0.93505859375}, {"start": 2718.1, "end": 2718.46, "word": " باقي", "probability": 0.8531901041666666}, {"start": 2718.46, "end": 2719.06, "word": " الفيروس", "probability": 0.931640625}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2719.21925, "duration_after_vad": 2616.7818749999897}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/dIVF2sBm1zc_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/dIVF2sBm1zc_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..545a06a301fd9aa85fbfd07a4d98c69052c997b9
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/dIVF2sBm1zc_raw.srt
@@ -0,0 +1,2464 @@
+1
+00:00:21,190 --> 00:00:23,530
+بسم الله الرحمن الرحيم اليوم موضوعنا ان شاء الله
+
+2
+00:00:23,530 --> 00:00:29,650
+موضوع كتير مهم وبيشمل مجموعة من ال unrelated يعني
+
+3
+00:00:29,650 --> 00:00:35,970
+لا لا تشترك في شيء الا انه ال main target تبعها هو
+
+4
+00:00:35,970 --> 00:00:40,080
+ال liver وهي Hepatitis virusesومن الـ Hepatitis
+
+5
+00:00:40,080 --> 00:00:47,000
+viruses المشهورة جداً Hepatitis A وB وC وD وE طبعا
+
+6
+00:00:47,000 --> 00:00:50,600
+احنا مر معانا اكتر من واحد منهم بالمناسبة مثلا
+
+7
+00:00:50,600 --> 00:00:52,900
+Hepatitis A اتكلمنا عنه لما اتكلمنا عن ال
+
+8
+00:00:52,900 --> 00:00:56,480
+Enterovirus كنا نقول ان في فيروس اسمه Hepatitis A
+
+9
+00:00:56,480 --> 00:01:00,480
+واتكلمنا عن Hepatitis B virus لما كنا نتكلم عن ال
+
+10
+00:01:00,480 --> 00:01:06,180
+DNA Enveloped virusesواتكلمنا عن الـ HD اللي هو
+
+11
+00:01:06,180 --> 00:01:08,940
+الـ Hepatitis D أو الـ Delta لما اتكلمنا عن الـ
+
+12
+00:01:08,940 --> 00:01:13,240
+Defective Viruses فديبنا سيرة الـ B و الـ D في نفس
+
+13
+00:01:13,240 --> 00:01:16,720
+الوقت لما قلنا انه واحد helper للاخر اللي هو الـ
+
+14
+00:01:16,720 --> 00:01:20,600
+Defective اللي هو الـ D بعدين اتكلمنا مرة قلنا انه
+
+15
+00:01:20,600 --> 00:01:23,420
+في نوعين .. نعم بالظبط نوعين من ال Hepatitis
+
+16
+00:01:23,420 --> 00:01:26,720
+ينتقلوا عن الفكرة الأولى اللي هو الـ A و الـ A
+
+17
+00:01:27,840 --> 00:01:31,600
+Commonly these viruses are known as hepatitis
+
+18
+00:01:31,600 --> 00:01:35,740
+viruses لأن ال main target تبعهم هو ال liver يعني
+
+19
+00:01:35,740 --> 00:01:38,320
+هناك فيروسات مثل ال ابشتينبار فيروس و الcytome
+
+20
+00:01:38,320 --> 00:01:42,080
+yellow virus و ال yellow fever فيروس بيعملوا liver
+
+21
+00:01:42,080 --> 00:01:46,200
+infection لكن لأنه ال liver مش هو ال exclusive
+
+22
+00:01:46,200 --> 00:01:53,160
+organ لل infection بنسميهمش hepatitis virusو هنبدأ
+
+23
+00:01:53,160 --> 00:01:57,980
+ان شاء الله على طول في Hepatitis A وهو يبقى انترو
+
+24
+00:01:57,980 --> 00:02:01,540
+فيروس كنا مسميه زمان انترو فيروس 72 مار معناه برضه
+
+25
+00:02:01,540 --> 00:02:05,400
+هذا المسمى وهو يبقى single stranded او single
+
+26
+00:02:05,400 --> 00:02:09,860
+negative stranded RNA جينوم non enveloped ومؤكد
+
+27
+00:02:09,860 --> 00:02:12,640
+انه non enveloped لانه بنتقل عن طريق الفيكل oral
+
+28
+00:02:12,640 --> 00:02:17,280
+route وEicosahedral Nucleocapsid بيتكتر في السلطب
+
+29
+00:02:17,280 --> 00:02:20,240
+لازم في اتباع الخلايا only one zero type عشان ايه
+
+30
+00:02:20,240 --> 00:02:24,200
+برضه نجحنا انه نعمله فاكسين كويسما لهوش أي علاقة
+
+31
+00:02:24,200 --> 00:02:30,780
+أنتيجينية ولا تركيبية بالأخر Hepatitis virusالـ
+
+32
+00:02:30,780 --> 00:02:33,240
+mode of transmission بينتقل الـ fecal oral
+
+33
+00:02:33,240 --> 00:02:36,680
+transmission و ال human are the only known
+
+34
+00:02:36,680 --> 00:02:42,160
+reservoir for this virus الفيروس بيظهر في ال stool
+
+35
+00:02:42,160 --> 00:02:46,880
+تبع المرضى اسبوعين تقريبا قبل بدء الاعراض يعني
+
+36
+00:02:46,880 --> 00:02:50,440
+المريض بينقل الفيروس من البرادس تبعه الى الآخرين
+
+37
+00:02:50,440 --> 00:02:55,180
+تمام قبل ما تظهر عليه الاعراض و لذلك تفشل عملية ما
+
+38
+00:02:55,180 --> 00:02:58,280
+يسمى black quarantine بعرفش مار معاكم المصطلح قبلك
+
+39
+00:02:58,280 --> 00:03:02,720
+و تلقاه؟Quarantine معناه الحجر الصحي، الحجر الصحي
+
+40
+00:03:02,720 --> 00:03:08,580
+وهو من ضمن إجراءاته عزل المرضى أو المصابين بشكل
+
+41
+00:03:08,580 --> 00:03:14,880
+يضمن عدم انتقال المرض منهم إلى آخرين إذا ال
+
+42
+00:03:14,880 --> 00:03:18,940
+quarantine في هذه الحالة مالوش أي فايدة ليه لأنه
+
+43
+00:03:18,940 --> 00:03:23,680
+قبل ظهور اللي هو العراب Children are the most
+
+44
+00:03:23,680 --> 00:03:28,320
+frequently infected groupليش طيب برأيكم the most
+
+45
+00:03:28,320 --> 00:03:31,920
+infected group هم ال children؟ واحد ال immunity
+
+46
+00:03:31,920 --> 00:03:35,820
+اللي علاقة بال age، مظبوط؟ رقم اتنين هذا المرض
+
+47
+00:03:35,820 --> 00:03:39,960
+منتشر الأطفال إذا وصيبوا فيه وكبروا هنا، مش
+
+48
+00:03:39,960 --> 00:03:43,340
+هيصابوا فيه مرة، تاني، لأن ال adults بيكون صابوا
+
+49
+00:03:43,340 --> 00:03:47,680
+فيه و هم الصغار، فبتاني هم protected Children
+
+50
+00:03:47,680 --> 00:03:53,210
+بيكونوا تعرفوا انه فئةمعرضة أكتر من غير هذه
+
+51
+00:03:53,210 --> 00:03:56,170
+الأمراض المعرضة لمجموعة كبيرة من الأسباب ذكرتلكوا
+
+52
+00:03:56,170 --> 00:03:59,430
+أنا منها اللي هو ال age related immunity يعني
+
+53
+00:03:59,430 --> 00:04:04,050
+العلاقة بالمنع نفسها hyper activity عندهم نشاط
+
+54
+00:04:04,050 --> 00:04:08,930
+أكتر من غيرهم من الأعمار الأخرى رقم تلاتة they do
+
+55
+00:04:08,930 --> 00:04:12,970
+not observe بكلمة observe يعني لا يلتزموا مش بقى
+
+56
+00:04:12,970 --> 00:04:18,010
+لا يلاحظوا لا يلتزموا بالعادات اللي هي النظافة
+
+57
+00:04:18,010 --> 00:04:23,210
+الشخصية مثل غيرهملذلك بيلاقي انه بالفعل among
+
+58
+00:04:23,210 --> 00:04:27,810
+children الفكة ال oral، transmission للبرازايت أو
+
+59
+00:04:27,810 --> 00:04:30,610
+الفيروس بيكون أعلى من اللي هم الفئات العمرية
+
+60
+00:04:30,610 --> 00:04:37,630
+الأخرىالمرض غالبا منتشر في تجمعات مثل مخيمات صيفية
+
+61
+00:04:37,630 --> 00:04:40,490
+summer camps أو boarding school كلمة boarding
+
+62
+00:04:40,490 --> 00:04:44,390
+school هي المدارس الداخلية، إيش هي مدارس داخلية؟
+
+63
+00:04:44,390 --> 00:04:47,570
+يعني الطفل بيروحش و بيروح كل يوم على المدرسة وإنما
+
+64
+00:04:47,570 --> 00:04:51,110
+بيذهب إلى المدرسة بيقعدله خمس شهور، ست شهور و
+
+65
+00:04:51,110 --> 00:04:54,190
+بعدين بياخدله إجازة و بيرجع مرة تانية هذا بيسموها
+
+66
+00:04:54,190 --> 00:04:56,250
+مدارس داخلية أو boarding schools
+
+67
+00:05:00,420 --> 00:05:03,160
+المصادر المعروفة أكتر منها هي الـcontaminated
+
+68
+00:05:03,160 --> 00:05:05,760
+water أو الطعام المغلق أو الطعام المغلق أو الطعام
+
+69
+00:05:05,760 --> 00:05:07,320
+المغلق أو الطعام المغلق أو الطعام المغلق أو الطعام
+
+70
+00:05:07,320 --> 00:05:09,720
+المغلق أو الطعام المغلق أو الطعام المغلق أو الطعام
+
+71
+00:05:09,720 --> 00:05:11,300
+المغلق أو الطعام المغلق أو الطعام المغلق أو الطعام
+
+72
+00:05:11,300 --> 00:05:13,040
+المغلق أو الطعام المغلق أو الطعام المغلق أو الطعام
+
+73
+00:05:13,040 --> 00:05:14,100
+المغلق أو الطعام المغلق أو الطعام المغلق أو الطعام
+
+74
+00:05:14,100 --> 00:05:16,260
+المغلق أو الطعام المغلق أو الطعام المغلق أو الطعام
+
+75
+00:05:16,260 --> 00:05:19,190
+المغلق أو الطعام المغلق أو الطعوالمحارب بتاعه
+
+76
+00:05:19,190 --> 00:05:23,590
+عبارة عن غذاء يعني popular فيه كتير من البلدان و
+
+77
+00:05:23,590 --> 00:05:26,710
+تنميته بالتم ماعرفش بتاعه عندكوا فكرة عن كيف
+
+78
+00:05:26,710 --> 00:05:30,270
+بيناموها لو بيستزرعوها ولا ماعندكوش فكرة بيجيبوا
+
+79
+00:05:30,270 --> 00:05:35,000
+حبل طويل و بينزله منه حبال في الميهفي البيوت طبعة
+
+80
+00:05:35,000 --> 00:05:38,920
+ال oyster بتلزج فى مين؟ بتلزج فى الحبال و بتفقس و
+
+81
+00:05:38,920 --> 00:05:42,320
+هي ملزجة فى الحبال و بتاكل و بتترذى من المياه اللى
+
+82
+00:05:42,320 --> 00:05:46,280
+حوالها و هي ملزجة فى الحبال و بتكبر و بعد ما
+
+83
+00:05:46,280 --> 00:05:48,840
+بيخلصوا بياخدوا الحامل و بيطلعوه و بنزله فى
+
+84
+00:05:48,840 --> 00:05:52,800
+الصندوق و بيودّوه على السوق او للتخزين او للتصدير
+
+85
+00:05:53,410 --> 00:05:57,170
+فهي تجارة وفي بعض البلدان اقتصادها مثل اليونان
+
+86
+00:05:57,170 --> 00:06:00,790
+اقتصادها كتير مبني على انه التنمية او استزراع ال
+
+87
+00:06:00,790 --> 00:06:05,110
+oyster فلما يكون ال oyster منما في مياه ملوثة
+
+88
+00:06:05,110 --> 00:06:10,690
+ويأكل هذا ال oyster مش مطبوخا يأكل نيئا يعني بدون
+
+89
+00:06:10,690 --> 00:06:14,610
+ما اتعرض لها حرارة ممكن يكون احد اهم اسباب نقلها
+
+90
+00:06:14,610 --> 00:06:20,170
+في بعض البلدانالـ H.A.V أو Hepatitis A Virus عادة
+
+91
+00:06:20,170 --> 00:06:24,550
+لا ينتقل بالدم والسبب في ذلك الجملة اللي وراها انه
+
+92
+00:06:24,550 --> 00:06:28,970
+لم يلاحظ نسبة كبيرة من الفيروس في الدم يعني
+
+93
+00:06:28,970 --> 00:06:33,870
+الفيريميا بتكون مالها قليلة في الدم ضعيفة فابتدت
+
+94
+00:06:33,870 --> 00:06:39,870
+ناخد ناخد فكرة عن الفيروسات اللي بتنتقل عن طريق
+
+95
+00:06:39,870 --> 00:06:45,290
+الحشرات يعني بوضة بتاخد وشبه الدم كده وشبه الدم
+
+96
+00:06:45,290 --> 00:06:50,030
+اللي بتاخدها؟قطرة مظبوط قطرة جدش يعني قطرة بال
+
+97
+00:06:50,030 --> 00:06:55,990
+very small volume صح ولا لأ عشان تقدر تمقل المرض
+
+98
+00:06:55,990 --> 00:06:59,530
+من انسان إلى انسان او من حيوان إلى انسان لازم يكون
+
+99
+00:06:59,530 --> 00:07:04,550
+مستوى الفيروس في الدم مرتفع جدا بحيث ان القطرة هذه
+
+100
+00:07:04,550 --> 00:07:08,370
+مجمول يكون فيها عدد كبير من اللي هو الفيروس اذا
+
+101
+00:07:08,370 --> 00:07:14,450
+فهمنا ليش بعض الفيروسات ممكن تنتقل او تمقل الحشرات
+
+102
+00:07:16,480 --> 00:07:19,140
+الفيروس من إنسان إلى إنسان أو من حرارة إلى إنسان
+
+103
+00:07:19,140 --> 00:07:24,120
+أو العكس لأن مستوى الفيريم يكون ماله مرتفع جدا هذا
+
+104
+00:07:24,120 --> 00:07:27,680
+low level chronic infection does not occur مابحدثش
+
+105
+00:07:27,680 --> 00:07:32,540
+أنه يتحول ال acute إلى chronic غالبا بيشفى تلقائيا
+
+106
+00:07:32,540 --> 00:07:36,420
+خلال فترة وديزة من أسبوعية لتلت أسابيع أو أربع
+
+107
+00:07:36,420 --> 00:07:43,620
+أسابيععملية الإمراض لهذا المرض مش كتير واضحة لكن
+
+108
+00:07:43,620 --> 00:07:46,580
+ال virus بيقولنا انه ممكن يكون بما ال replication
+
+109
+00:07:46,580 --> 00:07:52,700
+في الجهة الانتصاري و انا اتفقنا اصلا انه شدد حتى
+
+110
+00:07:52,700 --> 00:07:57,140
+قبل أن يأتي الشرطة اذا في replication في الجهة
+
+111
+00:07:57,140 --> 00:08:00,660
+الانتصاري بعدين بيروح على الدم كده مرة بمستويات
+
+112
+00:08:00,660 --> 00:08:06,010
+مالهابقليلة و هنعرف او هنحاول ان نفسر ليش مستوى
+
+113
+00:08:06,010 --> 00:08:10,890
+هنكون قليل في الدم لإنه بيظهر IGM و ال IGM انتوا
+
+114
+00:08:10,890 --> 00:08:15,190
+عارفينه هذا عبارة عن Pentamer Pentamer يعني خمسة
+
+115
+00:08:15,190 --> 00:08:19,050
+antibodies في بعض خمسة كل واحد منهم عنده اتنين
+
+116
+00:08:19,050 --> 00:08:23,410
+antigen binding site وبتالي الواحد بيرتبط بمين؟
+
+117
+00:08:23,410 --> 00:08:27,110
+بعشرة فيروسات تقريبا وهذا بيعمل clearance سريع
+
+118
+00:08:27,110 --> 00:08:32,750
+للفيروس من اللي هو الدمالفيروس بيروح على الدم
+
+119
+00:08:32,750 --> 00:08:37,510
+وينتقل إلى اللفر وغالبا الفيروس هذا لو نمناه في
+
+120
+00:08:37,510 --> 00:08:40,190
+cell culture مابتدمرش فيه effect cytopathic يعني
+
+121
+00:08:40,190 --> 00:08:44,350
+ال liver cell مابتدمرش من من؟ من الفيروس مابتدمر
+
+122
+00:08:44,350 --> 00:08:48,590
+من من؟ من ال cell mediated immunity كمان مرة وأكد
+
+123
+00:08:48,590 --> 00:08:52,890
+لكم أن هاي التدمير هو لصالح اللفر بمعنى لو طولك
+
+124
+00:08:53,100 --> 00:08:56,960
+الفيروس بدون من هاجمه بـ cytotoxic T cell، غالباً
+
+125
+00:08:56,960 --> 00:09:00,580
+الليفر كله حيصير فيه infection وماعرفش ال outcome
+
+126
+00:09:00,580 --> 00:09:04,680
+إيه حصير فيها في الآخر، إذا ال damage نتيجة عن مين
+
+127
+00:09:04,680 --> 00:09:10,610
+قلناها؟ ال attack by cytotoxic T cellكمان مرة ال
+
+128
+00:09:10,610 --> 00:09:13,950
+infection is cleared، the damage is repaired، and
+
+129
+00:09:13,950 --> 00:09:18,270
+no chronic infection ensues، يعني ما بيتبعاش عدوة
+
+130
+00:09:18,270 --> 00:09:22,570
+مظمنة، وال liver بتحسن، بيرجع ك normal كما كان في
+
+131
+00:09:22,570 --> 00:09:26,830
+الصباحHepatitis caused by different viruses cannot
+
+132
+00:09:26,830 --> 00:09:29,690
+be distinguished pathologically.يعني لو أخدنا قطعة
+
+133
+00:09:29,690 --> 00:09:31,390
+من اللي بقى لو وديناها على history pathologist
+
+134
+00:09:31,390 --> 00:09:36,070
+وقالوا شوفينا إيش التغيير اللي صار في A و في B و
+
+135
+00:09:36,070 --> 00:09:40,710
+في C و في D و في E و في G كمان، حيقولنا إنه both
+
+136
+00:09:40,710 --> 00:09:44,750
+أو كلهم all have similar destruction morphology
+
+137
+00:09:45,610 --> 00:09:50,370
+السبب ان المدمر هو واحد منه المدمر الـ cytotoxic T
+
+138
+00:09:50,370 --> 00:09:54,130
+cell اذا مافيش امكانية نميزهم عن بعض pathological
+
+139
+00:09:54,130 --> 00:09:59,370
+ال response كما ذكرنا لكم mainly IGM وهذه فيها
+
+140
+00:09:59,370 --> 00:10:02,610
+دلالتين الدلالة الأولى زي ما حكينا عليكم ان بنعمل
+
+141
+00:10:02,610 --> 00:10:07,390
+clearance من الدم بشكل سريع رقم اتنين ان انا بقدر
+
+142
+00:10:07,390 --> 00:10:14,270
+استخدم ال IGM الان كمؤشر على وجوداكتيف انفكشن وهو
+
+143
+00:10:14,270 --> 00:10:19,810
+الحقيقة الفحص المتوفر الآن للكشف عن Hepatitis A
+
+144
+00:10:19,810 --> 00:10:22,310
+إذا إذا بدنا نكشف عن Hepatitis A بدنا نكشف من خلال
+
+145
+00:10:22,310 --> 00:10:28,200
+مين البحث عن IGM تبع Hepatitis Aوهو كمان ذكرنا هو
+
+146
+00:10:28,200 --> 00:10:31,320
+مستخدم كمان في وين؟ في ال laboratory diagnosis
+
+147
+00:10:31,320 --> 00:10:36,320
+وغالبا بيكون موجود يعني لما الطفل او المصاب بيكون
+
+148
+00:10:36,320 --> 00:10:38,360
+عليه أعراض ال hepatitis ايش أعراض ال hepatitis
+
+149
+00:10:38,360 --> 00:10:42,360
+أهمها؟ سفرار لونه أصفر by the time of jaundice
+
+150
+00:10:42,360 --> 00:10:45,140
+تمام ان يكون jaundice عنده موجود لو جينا فحصنا
+
+151
+00:10:45,140 --> 00:10:49,200
+باللاجئ ال IGM موجود فهو مناسب للكشف عن هذا ال
+
+152
+00:10:49,200 --> 00:10:52,680
+virus طبعا احنا ممكن نستخدم كمان ال IGG لكن بنفس
+
+153
+00:10:52,680 --> 00:10:58,000
+الطريقة ال yell four fold increaseيقول إن الـ
+
+154
+00:10:58,000 --> 00:11:01,400
+appearance of IgM is followed by أو followed one
+
+155
+00:11:01,400 --> 00:11:04,480
+three weeks later by the production of IgG
+
+156
+00:11:04,480 --> 00:11:08,240
+antibodies، يعني ال IgG antibodies بيتبع ال IgM
+
+157
+00:11:08,240 --> 00:11:12,020
+لكن بياخد فترة طويلة، which provides lifelong
+
+158
+00:11:12,020 --> 00:11:15,600
+protection، إذا مين المسؤول عن الحماية المستقبلية
+
+159
+00:11:15,600 --> 00:11:19,910
+هو ال IgG؟الـ Clinical findings زي ما حكينالكوا كل
+
+160
+00:11:19,910 --> 00:11:24,190
+الـ Hepatitis تتلخص
+
+161
+00:11:24,190 --> 00:11:28,590
+فيه fever, anorexia, nausea, vomiting, jaundice و
+
+162
+00:11:28,590 --> 00:11:32,470
+هذه كلها typical للـ Hepatitis كمان بالاضافة إلى
+
+163
+00:11:32,470 --> 00:11:38,470
+ذلك المرضى بيلحظوا ان في انهم dark urine و pale
+
+164
+00:11:38,470 --> 00:11:43,350
+stool البراز بيكون باهت بينما ال urine بيكون very
+
+165
+00:11:43,350 --> 00:11:49,610
+dark بالنسبة للفحوصاتبتعرفوا ال liver function
+
+166
+00:11:49,610 --> 00:11:54,330
+test ALT و AST، إيش بيسموهم دولة؟ Transaminases،
+
+167
+00:11:54,330 --> 00:11:58,350
+Transaminases، إذا بيصير في elevation في ال
+
+168
+00:11:58,350 --> 00:12:02,850
+Transaminases ويعني ال liver function بتكون معناها
+
+169
+00:12:02,850 --> 00:12:06,850
+في هذا الحالة يعني down لأنه في destruction لل
+
+170
+00:12:06,850 --> 00:12:14,140
+liver cellsمعظم الحلقات تنتهي بسرعة في 2 إلى 4
+
+171
+00:12:14,140 --> 00:12:18,040
+أسابيع تقريبا
+
+172
+00:12:21,280 --> 00:12:25,100
+من تلاتة لاربع أسبوع بالمقارنة مين مع other
+
+173
+00:12:25,100 --> 00:12:29,200
+hepatitis virus لكن لو جينا القارنها مع الرشح one
+
+174
+00:12:29,200 --> 00:12:33,340
+day to two days ودلها ال influenza three to five
+
+175
+00:12:33,340 --> 00:12:38,460
+days يعني بنتكلم على short incubation period in
+
+176
+00:12:38,460 --> 00:12:43,800
+compared to other hepatitis virusأحنا ذكرنا عواض
+
+177
+00:12:43,800 --> 00:12:46,980
+Hepatitis A لكن ما ذكرنا معلومة بتقول ان most
+
+178
+00:12:46,980 --> 00:12:51,460
+infection with hepatitis A virus are asymptomatic
+
+179
+00:12:51,460 --> 00:12:56,520
+and only detected by the detection of IgG antibody
+
+180
+00:12:56,520 --> 00:13:02,310
+مين بروح بيعمل فحص لحاله و هو مش عيان؟ ماحدشيبقى
+
+181
+00:13:02,310 --> 00:13:06,350
+كده بنكشفها كده مرة من خلال دراسات من خلال survey
+
+182
+00:13:06,350 --> 00:13:10,350
+بنعمل survey لمجموعة من الناس اللي لاجي عندهم IGG
+
+183
+00:13:10,350 --> 00:13:13,890
+طب انتو قصبته في تاريخكم ب jaundice لما كان عندنا
+
+184
+00:13:13,890 --> 00:13:17,550
+jaundice وبتالي هذا تعبير عن مين؟ عن asymptomatic
+
+185
+00:13:17,550 --> 00:13:22,010
+infectionNo Chronic Hepatitis or Chronic Carrier
+
+186
+00:13:22,010 --> 00:13:26,110
+States وطبعا احنا بنأكد عليهم هدول المعلومتين عشان
+
+187
+00:13:26,110 --> 00:13:31,150
+نميزهم عن مين عن Hepatitis B وC اللي بيمتلكوا هتين
+
+188
+00:13:31,150 --> 00:13:34,830
+الخاصيتين انهم بتحولوا ل Chronic Hepatitis او
+
+189
+00:13:34,830 --> 00:13:39,670
+Chronic Carrier State وكلاهما مؤهل إلى البندر
+
+190
+00:13:39,670 --> 00:13:42,730
+الأخير اللي هو ال Hepatocellular Carcinoma اذا
+
+191
+00:13:42,730 --> 00:13:46,190
+مافيش Chronic Infection ولا Chronic Carrier State
+
+192
+00:13:46,190 --> 00:13:50,860
+ولا في عندي Hepatocellular Carcinomaمرض خفيف لطيف
+
+193
+00:13:50,860 --> 00:13:55,660
+بيصيب المريض أسبوعين تلاتة أو أربع حد أقصى وبيشفى
+
+194
+00:13:55,660 --> 00:13:59,380
+تلقائيا يعني الأطباء مابيعطوا علاجه انهم بيعملوا
+
+195
+00:13:59,380 --> 00:14:04,700
+بعض النصايح المرتبطة بالتخزية يعني عشان مارهقوش
+
+196
+00:14:04,700 --> 00:14:08,680
+الكبد اللذي يعاني في هذه اللحظة بيقولوله كل بعض
+
+197
+00:14:08,680 --> 00:14:13,300
+المأكلات اللتي لا يعني ترهق اللي هو الكبد لكن
+
+198
+00:14:13,300 --> 00:14:20,090
+مافيش antiviral treatment زي ما هنشوف كمان شويةالـ
+
+199
+00:14:20,090 --> 00:14:24,650
+Detection of IgM هو الـ Main Diagnostic Tool، أضعف
+
+200
+00:14:24,650 --> 00:14:28,810
+منها اللي هو الـ IgG، الـ Cell Culture possible،
+
+201
+00:14:28,810 --> 00:14:32,710
+لكن مادام فيه فحص بسيط زي الـ IgM وفعال، وانتوا
+
+202
+00:14:32,710 --> 00:14:36,410
+عارفين الـ IgM، ومعناته الآن اللي فيه Infection،
+
+203
+00:14:36,410 --> 00:14:40,070
+مش زي الـ IgG، فهو فعال وبتالي، لا داعي نعمل Cell
+
+204
+00:14:40,070 --> 00:14:45,250
+Culture Isolation في هذا الحالةNo Antivirus ثم كما
+
+205
+00:14:45,250 --> 00:14:49,850
+ذكرنا ال active immunization هو الآن الحل لل
+
+206
+00:14:49,850 --> 00:14:53,830
+prevention و ال active immunization بيحتوي على ال
+
+207
+00:14:53,830 --> 00:14:59,150
+virus المحتوي او المنمى يعني ال virus اللي مولود
+
+208
+00:14:59,150 --> 00:15:04,250
+في ال vaccine هذا نمناه على human cells و كثرناه و
+
+209
+00:15:04,250 --> 00:15:07,990
+بعدين قتلناه بال Formalin عملنا له inactivation
+
+210
+00:15:07,990 --> 00:15:11,670
+بال Formalin اذا هو killed virus
+
+211
+00:15:13,760 --> 00:15:18,140
+في وقتها بشكل جرعتين جرعة الان وجرعة بعد ست شهور
+
+212
+00:15:18,140 --> 00:15:21,340
+او اتناشر شهر يعني من ست شهور الى اتناشر شهر كجرعة
+
+213
+00:15:21,340 --> 00:15:26,180
+عايش مالها دايمة اذا only two doses ولا يوجد
+
+214
+00:15:26,180 --> 00:15:31,140
+توصيات باضافة اي جرعات اضافية اخرى اذا هو فقط two
+
+215
+00:15:31,140 --> 00:15:36,600
+doses واحدة وfollowed by a poster six twelve month
+
+216
+00:15:36,600 --> 00:15:38,800
+later
+
+217
+00:15:40,340 --> 00:15:45,440
+الـ Vaccine لمين يُعطى؟ يُعطى لفئتين أساسيتين وفئة
+
+218
+00:15:45,440 --> 00:15:49,500
+ثالثة مهمشة أنه طبعا مش مورود الحمد لله Travelers
+
+219
+00:15:49,500 --> 00:15:56,080
+اللي هم اللي بيسافروا إلى بلدان نامية اللي فيها
+
+220
+00:15:56,080 --> 00:16:01,220
+يعني المرض منتشر ولو لم يكن قد أصيبوا في السابق لم
+
+221
+00:16:01,220 --> 00:16:05,250
+يكن أن هم نفسهم الأشخاص دولة مانصبوش في السابقfor
+
+222
+00:16:05,250 --> 00:16:11,030
+children ages 2 to 12 to 18 years old إذن من سنتين
+
+223
+00:16:11,030 --> 00:16:15,110
+إلى تمنتاشر سنة لأطفال والفئة الأخيرة اللي هي اللي
+
+224
+00:16:15,110 --> 00:16:22,050
+قلنا لكوا عنهم ال homosexuals الآن في المقطع
+
+225
+00:16:22,050 --> 00:16:27,130
+الأخير في اللوحة نتكلم عن حاجة مهمةأو مفهوم مهم
+
+226
+00:16:27,130 --> 00:16:33,010
+إذا أنا عندي خمس تلاف طفل شهريًا جونا في قطاع غزاس
+
+227
+00:16:33,010 --> 00:16:37,710
+بالمثال سنويا بطلع يجدش ستين ألف ستين ألف يعني بدي
+
+228
+00:16:37,710 --> 00:16:42,730
+ستين ألف ضرب اتنين لما جرعتين ضرب اتنين هيجدش سعره
+
+229
+00:16:42,730 --> 00:16:47,050
+مية عشرين الف جرعة من ال vaccine لو كانت الجرعة
+
+230
+00:16:47,050 --> 00:16:52,170
+ثمنها مثلا عشرين دولار عشرين دولار احنا جونا المرض
+
+231
+00:16:52,170 --> 00:16:56,710
+كان موجود ومنتشر ومازال موجود يعنيأنه أحسن أعطي
+
+232
+00:16:56,710 --> 00:17:00,810
+الفاكسين هيك، a haphazard و اللي يعمل فحوصات
+
+233
+00:17:00,810 --> 00:17:04,330
+للناس، و اللي بيطلع عنده positive antibody، إيش
+
+234
+00:17:04,330 --> 00:17:08,560
+بنقولله؟ما تاخدش اللي هو الفاكسين الفحص إذا كان
+
+235
+00:17:08,560 --> 00:17:12,440
+تكلفته خمس دولار والفاكسين مثلا عشرين دولار فانا
+
+236
+00:17:12,440 --> 00:17:17,880
+بكون أفارج كده عشر خمس دولار وماعطيتش شخص فاكسين
+
+237
+00:17:17,880 --> 00:17:22,180
+بدون داعي هذه اعتقد انه wise policy ان الإنسان
+
+238
+00:17:22,180 --> 00:17:25,600
+يفكر فيها بشكل جيد وهذه هي التوصية اللي موجودة في
+
+239
+00:17:25,600 --> 00:17:30,210
+اللوحة اللي أمامنافيه فاكسين قامله جديد اسمه الـ
+
+240
+00:17:30,210 --> 00:17:33,630
+Twinrix والـ Twinrix هذا عبارة عن مزيج بين
+
+241
+00:17:33,630 --> 00:17:40,030
+Hepatitis A و Hepatitis B فيروس ما بيختلف عن اتنين
+
+242
+00:17:40,030 --> 00:17:43,990
+فرادة اللهم اننا ايه؟ جمعناهم مع بعض يعني اللي كان
+
+243
+00:17:43,990 --> 00:17:49,590
+موجود لحاله لحاله حطناهم في one vial واستخدمناهمفي
+
+244
+00:17:49,590 --> 00:17:52,510
+كمان حدث اسمه passive immunization ال passive
+
+245
+00:17:52,510 --> 00:17:56,910
+immunization ان انا اعطي immunoglobulin بيقول هل
+
+246
+00:17:56,910 --> 00:17:59,730
+بينفع ان انا اعطي immunoglobulin في حالة ال
+
+247
+00:17:59,730 --> 00:18:04,390
+hepatitis A و ان نعم لو كان واحد متوقع انه صار
+
+248
+00:18:04,390 --> 00:18:08,450
+exposure له تمام كيف اتوقع انه صار exposure بان
+
+249
+00:18:08,450 --> 00:18:15,710
+واحد من اللي حوله صار عنده العرعب
+
+250
+00:18:15,710 --> 00:18:18,190
+تبع ال hepatitis A و تم تشخيصه انه hepatitis A
+
+251
+00:18:19,000 --> 00:18:25,640
+فممكن يُعطى كويقاية أو ممكن يُعطى للمرضى أنفسهم to
+
+252
+00:18:25,640 --> 00:18:31,140
+mitigate وكلمة mitigate يعني يخفف تمام؟ للتخفيف من
+
+253
+00:18:31,140 --> 00:18:33,680
+.. احنا مش قولنا من ال spine لأربع عصابي على سبيل
+
+254
+00:18:33,680 --> 00:18:36,640
+المثال وفيه اصفرار وفيه anorexia وفيه fever وكده
+
+255
+00:18:36,640 --> 00:18:38,980
+هذا ال .. هذا ال .. ال .. ال minoglobulin ممكن
+
+256
+00:18:38,980 --> 00:18:42,960
+يخفف اللي هو من حد الأعراض للمرضى، إذا for
+
+257
+00:18:42,960 --> 00:18:46,240
+prevention and treatment ممكن نستخدم اللي هو ال
+
+258
+00:18:46,240 --> 00:18:49,910
+passive immunizationلكن الحقيقة الخطوة الأهم على
+
+259
+00:18:49,910 --> 00:18:53,310
+الإطلاق في ال prevention هو الصحة العامة يا جماعة
+
+260
+00:18:53,310 --> 00:18:57,390
+الصحة العامة و ال proper sewage disposal proper
+
+261
+00:18:57,390 --> 00:19:04,030
+personal hygiene proper hand washing هذه كلها من
+
+262
+00:19:04,030 --> 00:19:08,870
+شأنها أن تخفض عدد حالات الإصابة بالأمراض المنتقلة
+
+263
+00:19:08,870 --> 00:19:14,660
+من الفيكل oral إلى عداد مخفضة جداخلصنا بقى
+
+264
+00:19:14,660 --> 00:19:23,620
+Hepatitis A باربع كلمات بسيطة و مؤلم و مؤذى لكنه
+
+265
+00:19:23,620 --> 00:19:27,300
+غير خطير with no consequences يعني مافيش عنده في
+
+266
+00:19:27,300 --> 00:19:33,280
+الآخر تبعات صحية زي Hepatitis B و C نيجي الآن لل
+
+267
+00:19:33,280 --> 00:19:36,700
+Hepatitis الخطير اللي كلنا في العالم بليارات و
+
+268
+00:19:36,700 --> 00:19:41,140
+دولارات على الأقل حتى نقوم بفحص المتبرعين بالدم
+
+269
+00:19:42,110 --> 00:19:46,410
+مظبوط هو جزء من أي متبرع في الدم لازم يفحص له
+
+270
+00:19:46,410 --> 00:19:53,570
+Hepatitis B وC وHIV من الواقفة لبعض الفحصات الأخرى
+
+271
+00:19:53,570 --> 00:19:58,090
+من خصائصه أنه بيتمي لعائلة اسمها Hepadnaviruses و
+
+272
+00:19:58,090 --> 00:20:04,430
+تحت أي صنف درسنا احنا دي DNA enveloped virus it
+
+273
+00:20:04,430 --> 00:20:07,930
+has a 42 nanometer enveloped variant ومدام
+
+274
+00:20:07,930 --> 00:20:10,750
+enveloped يبقى مستحيل ينتقل زي أخوه اللي جابه قبل
+
+275
+00:20:10,750 --> 00:20:17,490
+قليللن ينتقل عبر الفكل oral route ان ايكوزا هيدرال
+
+276
+00:20:17,490 --> 00:20:21,150
+نوكليوكابسيد وهذا الغرابة الأخيرة من أغرب
+
+277
+00:20:21,150 --> 00:20:25,730
+الفيروسات انه عبارة عن partially double-stranded
+
+278
+00:20:25,730 --> 00:20:31,360
+DNA genome لان المفروض انه circularتمام؟ و double
+
+279
+00:20:31,360 --> 00:20:34,300
+-stranded يعني بيذكرنا بمين؟ بالـ Plasmid بيذكرنا
+
+280
+00:20:34,300 --> 00:20:39,000
+بالـ Plasmid لكن من طرف بالجيء مش مرتبط مع الطرف
+
+281
+00:20:39,000 --> 00:20:41,980
+الآخر طرف التاني overlapping يعني المفروض انهم
+
+282
+00:20:41,980 --> 00:20:45,220
+يكونوا ملتقين هذا عامل overlapping وبتالي هذا
+
+283
+00:20:45,220 --> 00:20:49,260
+بنسمي partially double-stranded مش مش مش كله
+
+284
+00:20:49,260 --> 00:20:54,160
+double-stranded يبجعي وجهة غربة في هذا الفيروس انه
+
+285
+00:20:54,160 --> 00:20:57,740
+قلنا partially double-stranded في كمان شغل تانية
+
+286
+00:20:58,370 --> 00:21:01,550
+غريبة فيه انه في عنده reverse transcriptase و انا
+
+287
+00:21:01,550 --> 00:21:04,090
+كنا نظن انه فقط مين اللي عنده reverse
+
+288
+00:21:04,090 --> 00:21:07,590
+transcriptase اللي ال retro فيروس زي ال HIV و ال
+
+289
+00:21:07,590 --> 00:21:12,950
+HTLV 1 and 2 لكن اللي جينا عنده هذا لأ و اللي اغرب
+
+290
+00:21:12,950 --> 00:21:19,100
+من ذلك انه ال enzyme بيمتلك صفتيندى RNA dependent
+
+291
+00:21:19,100 --> 00:21:22,940
+و DNA dependent activity RNA dependent و DNA
+
+292
+00:21:22,940 --> 00:21:28,220
+dependent activity يعني هو أنزيم بيشتغل بطريقتين ف
+
+293
+00:21:28,220 --> 00:21:31,960
+reverse transcriptase هدى RNA dependent و فيه DNA
+
+294
+00:21:31,960 --> 00:21:34,980
+dependent polymerase مش هو double stranded فبيشتغل
+
+295
+00:21:34,980 --> 00:21:37,580
+على ال single stranded و بيشتغل على ال double
+
+296
+00:21:37,580 --> 00:21:42,260
+stranded اذا هو بالفعل فيروس بيستحق مننا انه نهتم
+
+297
+00:21:42,260 --> 00:21:47,330
+فيه رقم تلاتة في الغرابةالمفروض ان الفيروس يركز
+
+298
+00:21:47,330 --> 00:21:51,570
+على إنتاج نسخ منه هو، صح؟ اللي هتبقى لك هذا
+
+299
+00:21:51,570 --> 00:21:59,430
+الفيروس بينتج نسخ إضافية، قشور من غير قشور، من غير
+
+300
+00:21:59,430 --> 00:22:03,970
+مادة وراثية جوا، وهو غريب في الفيروسات، صح؟ من غير
+
+301
+00:22:03,970 --> 00:22:09,990
+مادة وراثية، قد تصل نسبة إنتاجه للقشور بالمقارنة
+
+302
+00:22:09,990 --> 00:22:15,440
+مع المادة الوراثية ألف إلى واحديعني واحد فيروس
+
+303
+00:22:15,440 --> 00:22:20,120
+حقيقي والأولى في الشمالة من دولها قشور Shells يعني
+
+304
+00:22:20,120 --> 00:22:24,620
+حاجات فاضية مكوّنة فقط من حاسمة Surface Antigen
+
+305
+00:22:24,620 --> 00:22:30,900
+طبعا هذه يعني قد يكون إليها برضه حكمة في الفيروس
+
+306
+00:22:30,900 --> 00:22:34,240
+أنه ماانتجهاشها كده هال بازارت اعطوكوا مثال صغير
+
+307
+00:22:34,240 --> 00:22:42,600
+ال Surface Antigenاللي هو بيغطي ال virus هو نفسه
+
+308
+00:22:42,600 --> 00:22:48,080
+المكوّن لل shells الفارغة هذه ألف لو أحد لأ لما
+
+309
+00:22:48,080 --> 00:22:52,180
+اسم الإنسان يتعرف على ال antigen هذا و يكوّنله
+
+310
+00:22:52,180 --> 00:22:55,420
+أجسام مضادة، الأجسام المضادة بدل ما تهدم الفيروس
+
+311
+00:22:55,420 --> 00:23:00,150
+تجمين؟بتهاجم الـ shells الفاضية هذه وبترتبط معاه،
+
+312
+00:23:00,150 --> 00:23:04,330
+إذا هو جاعت بلجّط ال antibodies من وين؟ من الدم،
+
+313
+00:23:04,330 --> 00:23:09,770
+من الجسم، فهي طريقة بكية لخداع اللي هو الجهاز
+
+314
+00:23:09,770 --> 00:23:13,490
+المناعي، فهذا هو المخلوق الصغير اللي دي لا يعي
+
+315
+00:23:13,490 --> 00:23:18,230
+شيئا يستطيع أن يناور ويحاور مع جهاز المناع طبعا
+
+316
+00:23:18,230 --> 00:23:23,310
+بينجح أحيان وبيفشل أحيان كما كل الأسلحة الدفاعية
+
+317
+00:23:23,310 --> 00:23:30,360
+والهجوميةإذن فيروس غريب بكل المعاهد من قولنا إنه
+
+318
+00:23:30,360 --> 00:23:32,140
+من أهم الانتجينات اللي موجودة فيه اللي هو ال
+
+319
+00:23:32,140 --> 00:23:35,400
+surface antigen وجب أن تحفظوه جيدا خدوا بالكوا
+
+320
+00:23:35,400 --> 00:23:38,700
+Hepatitis B فيروس و C فيروس لازم تكونوا عارفين
+
+321
+00:23:38,700 --> 00:23:42,800
+عنهم معلومات نيحة لأنهم هم مثار ال testing المستمر
+
+322
+00:23:42,800 --> 00:23:46,310
+أو الروتيني في المختبرةعندها surface antigen
+
+323
+00:23:46,310 --> 00:23:51,870
+بيسميه HBSAG، Hepatitis B Surface Antigen، وعندها
+
+324
+00:23:51,870 --> 00:23:56,110
+Hepatitis C Core Antigen، وعندها Hepatitis E
+
+325
+00:23:56,110 --> 00:24:02,610
+Antigen، إذا فاندي surface و S و C و E ال surface
+
+326
+00:24:02,610 --> 00:24:08,210
+اسمه surface، ال E و ال C مولودين في ال core، جوا،
+
+327
+00:24:08,210 --> 00:24:11,590
+جوا الفيروس، بينما ال S بيكون مولوده على مين؟ على
+
+328
+00:24:11,590 --> 00:24:16,430
+ال surfaceطب علشان أنا بركز عليهم هدولة، بركز
+
+329
+00:24:16,430 --> 00:24:20,270
+عليهم لإنهم هدولة يعتبروا markers، و أول مرة
+
+330
+00:24:20,270 --> 00:24:26,130
+بنتكلم عن markers في physiologyالان بدي افهم وجود
+
+331
+00:24:26,130 --> 00:24:30,250
+هذا ايش بيعني وجود هذا او غياب هذا ايش بيعني
+
+332
+00:24:30,250 --> 00:24:33,250
+فبالتالي هدولة بنسميهم احنا Hepatitis Markers
+
+333
+00:24:33,250 --> 00:24:38,570
+بنروح لمن؟ لل Anti لكل واحد من هدولة Anti-Hb
+
+334
+00:24:38,570 --> 00:24:46,250
+Surface Antigen, Anti-Hb Core Antigen, Anti-Hb E
+
+335
+00:24:46,250 --> 00:24:50,770
+Antigenالانتيجينات وال antibodies تبعونهم هدول
+
+336
+00:24:50,770 --> 00:24:53,810
+اللي هيتبعون اسمهم hepatitis markers او hepatitis
+
+337
+00:24:53,810 --> 00:24:59,750
+B markers يعني مثال صغير عشان نفهم المسألة و كتير
+
+338
+00:24:59,750 --> 00:25:06,110
+بيجيونا ناس بيسألوا العريس عنده تتشخص انه هباطيتس
+
+339
+00:25:06,110 --> 00:25:13,670
+surface antigen لو تزوجهل يمكن أن ينقل زوجته المرض
+
+340
+00:25:13,670 --> 00:25:18,150
+لها؟ لا نستطيع ان نجاوب مباشرة ايه نعمل ال markers
+
+341
+00:25:18,150 --> 00:25:22,830
+اذا وجدنا عنده ال core antigen موجود بيقولهم اه
+
+342
+00:25:22,830 --> 00:25:27,670
+بينقل المرضبينقل ايش نامنا هذا؟ Indicator of ايش؟
+
+343
+00:25:27,670 --> 00:25:31,070
+Transmissibility يعني ممكن انه ينتقل المرض من
+
+344
+00:25:31,070 --> 00:25:34,270
+انسان الى انسان، اذا ال hepatitis بتختلف عن ال
+
+345
+00:25:34,270 --> 00:25:38,010
+other viruses بأنه بنتعرف على ال antigenات تبعتها
+
+346
+00:25:38,010 --> 00:25:41,890
+وع ال antibodies تبعت ال antigenات عشان نفهم كمان
+
+347
+00:25:41,890 --> 00:25:46,850
+مرة ال case definition او ال stages اللي بيمور
+
+348
+00:25:46,850 --> 00:25:48,410
+فيها هذا المريض
+
+349
+00:25:51,250 --> 00:25:55,170
+هذا التشبيه يعني بسيط لزي ما حكينا انه هذا partial
+
+350
+00:25:55,170 --> 00:25:59,070
+double-stranded DNA هذا اللي هو ال DNA polymerase
+
+351
+00:25:59,070 --> 00:26:02,850
+و ال core ال E-antigen لاحظوا هنا ال antigen موجود
+
+352
+00:26:02,850 --> 00:26:06,310
+بين ال envelope brain اللي هو ال core بينما ال
+
+353
+00:26:06,310 --> 00:26:10,770
+hepatitis ب core antigen موجود في ال core نفسه في
+
+354
+00:26:10,770 --> 00:26:13,330
+الداخل طبعا ال surface antigen اللي هو اللي موجود
+
+355
+00:26:13,330 --> 00:26:15,290
+على بيننا على الصدر
+
+356
+00:26:18,540 --> 00:26:21,000
+اتفقنا انه في ال core في DNA dependent DNA
+
+357
+00:26:21,000 --> 00:26:25,980
+polymerase وفيه four genes مهمين جدا لازم نتعرف
+
+358
+00:26:25,980 --> 00:26:31,360
+عليهم واحد خاص بال activation لل viral
+
+359
+00:26:31,360 --> 00:26:38,300
+transcription مار معانا السابق two genes مهمين جدا
+
+360
+00:26:38,300 --> 00:26:45,880
+واسمه تات تات و taxالتاكس والتات كانوا موجودين
+
+361
+00:26:45,880 --> 00:26:50,840
+واحد في الـ HIV والتاكس في الـ HTLV وجودن هدول
+
+362
+00:26:50,840 --> 00:26:56,200
+اتنين Transcription Activatorsبس الـ TAT كان للـ
+
+363
+00:26:56,200 --> 00:27:01,140
+Viral RNA و الـ TAX كان للـ Viral and Cellular RNA
+
+364
+00:27:01,140 --> 00:27:04,900
+هو السبب اللي عزوناه ان هو بيكون كارسينوما او
+
+365
+00:27:04,900 --> 00:27:09,480
+لمفاما تمام؟ بيسبب سلطان في الدم هذا ايضا ال X
+
+366
+00:27:09,480 --> 00:27:12,780
+-protein بيعمل activation لمين؟ لل Viral RNA
+
+367
+00:27:12,780 --> 00:27:15,740
+transcription اللي هو هذا يا بنات، شفينه؟ ال X
+
+368
+00:27:15,740 --> 00:27:19,130
+-proteinفي عندي Surface Envelope Protein اللي هو
+
+369
+00:27:19,130 --> 00:27:20,930
+الـ Surface Antigen اللي حكينا عنه Surface Antigen
+
+370
+00:27:20,930 --> 00:27:26,190
+الـ Core Nucleocapsid Protein والـ DNA Polymerase
+
+371
+00:27:26,190 --> 00:27:29,310
+and X Protein إذن الأربع الجينات الرئيسية هم اللي
+
+372
+00:27:29,310 --> 00:27:32,790
+ذكرناهم الآن الـ DNA Polymerase اللي ذكرناها بنات
+
+373
+00:27:32,790 --> 00:27:37,810
+قبل قليل قلنا عنه has both RNA-dependent وبين غسين
+
+374
+00:27:37,810 --> 00:27:42,010
+reverse transcriptase and DNA-dependent activity
+
+375
+00:27:42,220 --> 00:27:46,840
+هذا الانزيم يتناسب مع طبيعة مين؟ مع طبيعة المادة
+
+376
+00:27:46,840 --> 00:27:49,560
+الوراثية اللي موجودة في هذا الفيروس ايش هي طبيعة
+
+377
+00:27:49,560 --> 00:27:53,760
+المادة الوراثية؟ partially double-stranded يعني في
+
+378
+00:27:53,760 --> 00:27:57,580
+جزء منه اشماله single-stranded ف single-stranded
+
+379
+00:27:57,580 --> 00:28:00,240
+عشان يتحول ل double-stranded ايش بده؟ بده الفيروس
+
+380
+00:28:00,240 --> 00:28:05,040
+Transcriptase في هذا الحالة الـ Electromicroscopy
+
+381
+00:28:05,040 --> 00:28:09,160
+لاحظنا مجموعة مختلفة من ال particles لهذا الفيروس
+
+382
+00:28:09,160 --> 00:28:14,350
+اللي ذكرناه معاكمواحد منهم 42 نانومتر اللى هو ال
+
+383
+00:28:14,350 --> 00:28:19,210
+virus اللى وضّهناه لكوا سورة قبل قليل وواحد 22
+
+384
+00:28:19,210 --> 00:28:25,650
+spheres يعني اصغر من 42 نصفه تقريباو filaments
+
+385
+00:28:25,650 --> 00:28:31,010
+طويلة لكن ال width بتاعها برضه تقريبا كدهش؟ اتنين
+
+386
+00:28:31,010 --> 00:28:36,870
+و عشرين نانو متر هدول ال particles كده مرة تلاتة
+
+387
+00:28:36,870 --> 00:28:41,850
+فيروس حقيقي والتنتين هدول عبارة فقط عن surface
+
+388
+00:28:41,850 --> 00:28:47,740
+antigen لا يوجد بديهم اي مادة وراتبالـ Filaments
+
+389
+00:28:47,740 --> 00:28:50,760
+and Small Spheres to Variants is جداشكم ان ال
+
+390
+00:28:50,760 --> 00:28:55,240
+percentage من الف الى واحد يعني الفريون واحد مقابل
+
+391
+00:28:55,240 --> 00:28:59,220
+الف من هدولة طبعا بما انهم محتوش على مادة وراثية
+
+392
+00:28:59,220 --> 00:29:04,910
+يبجي هم لو انتقلوا للانسان غير ماضيهذه الشكل بوضح
+
+393
+00:29:04,910 --> 00:29:07,550
+انها بتلات أشكال اللى هو ال virus particles
+
+394
+00:29:07,550 --> 00:29:10,990
+الكاملة و ال sphere اللى بتشبه ال virus لكن حجمها
+
+395
+00:29:10,990 --> 00:29:13,990
+ليش ماله صغير و ال filaments اللى حاكينا عنها
+
+396
+00:29:13,990 --> 00:29:18,030
+filament طويلة و كلهم مكونين كمان مرة من surface
+
+397
+00:29:18,030 --> 00:29:22,410
+antigen بالنسبة
+
+398
+00:29:22,410 --> 00:29:26,530
+لل Astrology تبع هذا الفيروس
+
+399
+00:29:27,810 --> 00:29:33,790
+عن مفروض صناعة الفاكسينة، نعتبرها مجموعة من واحد
+
+400
+00:29:33,790 --> 00:29:38,590
+انتجن، يعني واحد نوع، مستقل، اسمه surface antigen،
+
+401
+00:29:38,590 --> 00:29:43,130
+تمام؟ وكل الهيباطيتس بيروس بيهباطيتس بيهباطيتس
+
+402
+00:29:43,130 --> 00:29:44,490
+بيهباطيتس بيهباطيتس بيه بيروس بيه تحتوي على one
+
+403
+00:29:44,490 --> 00:29:50,150
+common hepatitis surface antigenfor the sake of
+
+404
+00:29:50,150 --> 00:29:53,730
+epidemiology، ايش يعني epidemiology؟ يعني مثلا،
+
+405
+00:29:53,730 --> 00:29:58,890
+عندي انا حالات hepatitis، بدّي اعرف من هو مصدرها،
+
+406
+00:29:58,890 --> 00:30:03,790
+بنشوفها في المرضى، بنشوف ال serology تبعهم، ال
+
+407
+00:30:03,790 --> 00:30:08,520
+groups تبعهم أو ال subgroupsوبنشوف مين أقرب جهة
+
+408
+00:30:08,520 --> 00:30:13,780
+إلنا تحتلق نفس الـ Subgroups مثلا جزء من المرضون
+
+409
+00:30:13,780 --> 00:30:17,240
+احنا بتعالج وان؟ في مصر و جزء مننا بتعالج في
+
+410
+00:30:17,240 --> 00:30:21,580
+فلسطين المحتلة عام 48 صح ولا؟ لأن يا هل ترى المرضى
+
+411
+00:30:21,580 --> 00:30:24,360
+اللى في غزة بيحتوى على نفس ال antigen من ال
+
+412
+00:30:24,360 --> 00:30:28,440
+hepatitis B surface antigen واحد ولا اكتر من واحد
+
+413
+00:30:28,440 --> 00:30:32,500
+طب نقدر نعرف من وان مصدر فممكن هذا التعرف على
+
+414
+00:30:32,500 --> 00:30:37,900
+المصدرناخد قرار إنه نمنع مرضانة يروحوا على هذه
+
+415
+00:30:37,900 --> 00:30:40,920
+المنطقة لإنهم بيكتسبوا مثلا فيروسات من هذه اللي
+
+416
+00:30:40,920 --> 00:30:46,520
+..الآن كيف بتم التصنيف؟ في أنديا بنات common group
+
+417
+00:30:46,520 --> 00:30:53,890
+specific أنديا اسمه A و two sets of epitopesاما D
+
+418
+00:30:53,890 --> 00:31:05,210
+او Y اما D او Y اما D
+
+419
+00:31:05,210 --> 00:31:06,730
+او Y اما D او Y اما D او Y اما D او Y اما D او Y
+
+420
+00:31:06,730 --> 00:31:07,350
+اما D او Y اما D او Y اما D او Y اما D او Y اما D
+
+421
+00:31:07,350 --> 00:31:07,350
+او Y اما D او Y اما D او Y اما D او Y اما D او Y
+
+422
+00:31:07,350 --> 00:31:07,550
+اما D او Y اما D او Y اما D او Y اما D او Y اما D
+
+423
+00:31:07,550 --> 00:31:07,810
+او Y اما D او Y اما D او Y اما D او Y اما D او Y
+
+424
+00:31:07,810 --> 00:31:07,810
+اما D او Y اما D او Y اما D او Y اما D او Y اما D
+
+425
+00:31:07,810 --> 00:31:09,930
+او Y اما D او Y اما D او Y اما D او Y اما D او Y
+
+426
+00:31:09,930 --> 00:31:14,150
+اما D او Y اما D او Y اما D او Y اما
+
+427
+00:31:18,970 --> 00:31:27,190
+عشان اختيار ال D مرة اخرى من وان ست مع ال W من اخر
+
+428
+00:31:27,190 --> 00:31:27,890
+ست
+
+429
+00:31:35,850 --> 00:31:39,270
+وبالتالي، بسيطة عندي فقط جانتجانات أربعة اللي هم
+
+430
+00:31:39,270 --> 00:31:44,830
+Serotype كمان مرة الغرض منهم ليس روتين تيستنج،
+
+431
+00:31:44,830 --> 00:31:47,650
+يعني هدوله مندوش، هلاهم احنا في الفحوصات، لكن في
+
+432
+00:31:47,650 --> 00:31:53,970
+الدراسات الوبائية، لابد البحث عن هذه الانتجانات
+
+433
+00:31:53,970 --> 00:31:59,630
+لماذا يتجه هذا الفيروس specifically للـ liver؟ ما
+
+434
+00:31:59,630 --> 00:32:03,630
+الذي يجعل ال liver محبب لهذا الفيروس؟ في سببين يا
+
+435
+00:32:03,630 --> 00:32:08,100
+بنات؟إنه liver cells لها receptors أو عليها
+
+436
+00:32:08,100 --> 00:32:12,560
+receptors تمام بيرتبط فيها ل hepatitis virus
+
+437
+00:32:12,560 --> 00:32:16,480
+surface entry specifically هذا بسهل عملت مين ال
+
+438
+00:32:16,480 --> 00:32:21,460
+entry ل الفيروس في كمان الو عميل جوا اللي هو
+
+439
+00:32:21,460 --> 00:32:25,900
+الفيروس الو transcriptional factor او
+
+440
+00:32:25,900 --> 00:32:31,030
+transcription factor شايفينه هنا found onlyفي الـ
+
+441
+00:32:31,030 --> 00:32:34,210
+Hepatocyte هذا الـ Transcription factor هو اللي
+
+442
+00:32:34,210 --> 00:32:38,590
+بيساعد الفيروس عليه على انه يعمل ال replication
+
+443
+00:32:38,590 --> 00:32:42,730
+تبعه او يصنع ال mRNA وبتالي يستمر في عملية ال
+
+444
+00:32:42,730 --> 00:32:46,870
+replication humans are the only natural host for
+
+445
+00:32:46,870 --> 00:32:52,570
+HPV ماعناش معلومات ان في مخلوقات اخرى عندها
+
+446
+00:32:52,570 --> 00:32:56,770
+Hepatitis B virus there is no animal reservoir
+
+447
+00:32:59,320 --> 00:33:02,120
+Hepadma viruses are the only viruses that produces
+
+448
+00:33:02,120 --> 00:33:06,300
+genome DNA by reverse transcriptions with mRNA as
+
+449
+00:33:06,300 --> 00:33:10,340
+the template.طب هذا الكلام بعكس مين؟ يعني اللي
+
+450
+00:33:10,340 --> 00:33:12,660
+نعرفه عني الـHIV، الـHIV عنده reverse
+
+451
+00:33:12,660 --> 00:33:18,680
+transcriptase، لكن مش تشتغل ال mRNA كجالبالـ HIV
+
+452
+00:33:18,680 --> 00:33:21,640
+بيشتغل على الـ RNA جينوم تبعه كقالب لكن مش على
+
+453
+00:33:21,640 --> 00:33:26,100
+mRNA هذا بيستخدم ال messenger RNA كقالب يتحول منه
+
+454
+00:33:26,100 --> 00:33:30,160
+مين DNA إذا هو الفيروس الوحيد اللي بيمتلك هذه
+
+455
+00:33:30,160 --> 00:33:35,280
+الخاصة some of the progeny DNA integrates into the
+
+456
+00:33:35,280 --> 00:33:40,580
+host cell genome الآن هنا دخلنا في موضوع انه جزء
+
+457
+00:33:40,580 --> 00:33:44,260
+من ال من ال copies تبع المادة الوراثية تحت الفيروس
+
+458
+00:33:44,260 --> 00:33:49,330
+قديعني يصير لها دمج، دمج يعني معناه اخر
+
+459
+00:33:49,330 --> 00:33:56,190
+integration لل host genome، طبوش يعني ايه؟ بقول ان
+
+460
+00:33:56,190 --> 00:34:04,070
+هذا بفسر ان why some people may convert
+
+461
+00:34:04,070 --> 00:34:08,050
+from acute stage to اللي هو اللي تنسي او ال career
+
+462
+00:34:08,050 --> 00:34:13,960
+state، انه يضلوا حامل لهذا الفيروسProgeny HPV with
+
+463
+00:34:13,960 --> 00:34:18,040
+its hepatitis surface antigen-containing envelope
+
+464
+00:34:18,040 --> 00:34:21,640
+is released from the cell by budding فاكرين لما
+
+465
+00:34:21,640 --> 00:34:23,980
+اتكلمنا عن الـ replication احنا؟ قُلنا له كبرنات
+
+466
+00:34:23,980 --> 00:34:27,640
+ان البيروس هو داخل الخلية الحيوانيةبينتج ال
+
+467
+00:34:27,640 --> 00:34:30,380
+surface antigen تبعه أو ال antigenات تبعته و
+
+468
+00:34:30,380 --> 00:34:33,720
+بيطلعه هنا في ال membrane تبع الخلية اللي هو مصابة
+
+469
+00:34:33,720 --> 00:34:36,740
+و هو طالع بياخد يزن من ال membrane فبالتالي هو
+
+470
+00:34:36,740 --> 00:34:40,520
+بياخد ال membrane اللي هو فلمين لل antigenات تبعته
+
+471
+00:34:40,520 --> 00:34:44,200
+اللي هي ال surface antigen و كلمة budding بتعطينا
+
+472
+00:34:44,200 --> 00:34:49,800
+إحاب أنه أن الخلية ما زاد كما هي مابصرهاش
+
+473
+00:34:49,800 --> 00:34:54,420
+destruction Transmission and Epidemiology أو
+
+474
+00:34:54,420 --> 00:34:58,900
+Hepatitis BThree main modes of transmission واحدة
+
+475
+00:34:58,900 --> 00:35:04,080
+blood، اتنين during sexual intercourse، تلاتة
+
+476
+00:35:04,080 --> 00:35:12,000
+perinatal يعني من الأم إلى المولود الملاحظة
+
+477
+00:35:12,000 --> 00:35:19,940
+أن غزة الإبرة اللي سحبنا فيها دم أو اللي استخدمها
+
+478
+00:35:19,940 --> 00:35:26,220
+واحد ونقلها لإنسان تانيإنه بتنقل الفيروس أو بتنقل
+
+479
+00:35:26,220 --> 00:35:29,580
+المرض، هذا مؤشر على إنه إيش في عنده فياريميا، low
+
+480
+00:35:29,580 --> 00:35:32,760
+level ولا high level؟ high level فياريميا، بعكس
+
+481
+00:35:32,760 --> 00:35:36,840
+مين؟ هي بطاريتس A اللي احنا حاكينا عنها قبل قليل
+
+482
+00:35:36,840 --> 00:35:42,680
+HP Infection is especially prevalent in addicts،
+
+483
+00:35:42,680 --> 00:35:45,980
+addicts اللي هم المدمنين، اللي هم المدمنين
+
+484
+00:35:45,980 --> 00:35:50,380
+المخدرينWho use intravenous drugs اللي بيستخدموه،
+
+485
+00:35:50,380 --> 00:35:54,260
+هو طبعا انتوا عارفين العقاقير مختلفة، في عقاقير
+
+486
+00:35:54,260 --> 00:35:58,200
+بياخدوها عن طريق الفم، عن طريق التدخين، عن طريق
+
+487
+00:35:58,200 --> 00:36:02,580
+الأنف، بيستنشقوها، استنشاك، وفي عبر اللي هو الحقن،
+
+488
+00:36:02,580 --> 00:36:08,000
+وآخر مخدرات صارت مخدرات رقمية، digitalيستمع إلى
+
+489
+00:36:08,000 --> 00:36:13,260
+أصوات في أذنيه ويحصل على مفعول المخدر وهي مخدرات
+
+490
+00:36:13,260 --> 00:36:20,600
+تنتشر بشكل كبير في مجتمعنا العربي زي موسيقى يا
+
+491
+00:36:20,600 --> 00:36:25,840
+بنات، يعني wavelength معين بيعمل stimulation
+
+492
+00:36:25,840 --> 00:36:32,960
+للدماغفو بيحصل اللي هو الأثر النشوة اللي بيحصلها
+
+493
+00:36:32,960 --> 00:36:36,440
+الأشخاص اللي المؤقتة دي اللي بيستخدموها من
+
+494
+00:36:36,440 --> 00:36:40,200
+المخدرات تمام
+
+495
+00:36:40,200 --> 00:36:45,320
+Screening of blood for the presence of HPSAG has
+
+496
+00:36:45,320 --> 00:36:47,940
+greatly decreased the number of transfusion
+
+497
+00:36:47,940 --> 00:36:50,760
+associated cases of Hepatitis B في شغلتين احنا
+
+498
+00:36:53,190 --> 00:36:57,390
+عملناهم فى العالم و بالفعل خفضوا نسبة الإصابة بالـ
+
+499
+00:36:57,390 --> 00:37:01,130
+Hepatitis B واحد ال vaccination هنلاقي انه فى
+
+500
+00:37:01,130 --> 00:37:04,230
+vaccine احنا ذكرنا لما تكلمنا عن Hepatitis A و ان
+
+501
+00:37:04,230 --> 00:37:08,110
+فى Twinrix مظبوط فال vaccination كانت عاملة مهمة
+
+502
+00:37:08,110 --> 00:37:12,210
+انتوا ماعرفش انتوا مولد جديش لأ انا حاجب ماخدين
+
+503
+00:37:12,210 --> 00:37:16,190
+vaccine و مرتاحين يعنىالأجيال اللي جابلكوا اللي
+
+504
+00:37:16,190 --> 00:37:20,430
+كنا بتحيات طبية كنا كل دفعة انطلعهم على مستشفى
+
+505
+00:37:20,430 --> 00:37:26,290
+يتدربوا كنا نعملهم vaccination ل Hepatitis B معناه
+
+506
+00:37:26,290 --> 00:37:29,930
+احنا كنا كمان كنا مخططين انه المفروض انه احنا
+
+507
+00:37:29,930 --> 00:37:32,930
+نطعمهم حتى ما يدخلوا الجامعة لانه برضه بتعارضوا مع
+
+508
+00:37:32,930 --> 00:37:38,720
+قبره في المختبراتبسرعة الأيام جرت و لجينا أن
+
+509
+00:37:38,720 --> 00:37:43,060
+الأجيال اللي اتصلنا من الأجيال اللي تلقت من تلقت
+
+510
+00:37:43,060 --> 00:37:47,220
+هذا ال vaccine إذا الأول خطوة ال blood screening
+
+511
+00:37:47,220 --> 00:37:52,220
+في ال blood testing service في بنوك الدم يعني لا
+
+512
+00:37:52,220 --> 00:37:56,930
+يوجد الآن وحدة دمتنقل من إنسان إلى إنسان إلا تكون
+
+513
+00:37:56,930 --> 00:38:00,930
+مفهوصة للـ Hepatitis B surface antigen وبتالي هذا
+
+514
+00:38:00,930 --> 00:38:05,270
+خفض عدد الإصابات إلى عدد قليل جدا يعني حتى
+
+515
+00:38:05,270 --> 00:38:08,890
+Hepatitis C يمكن في غزة صارت أعلى من Hepatitis B
+
+516
+00:38:08,890 --> 00:38:20,430
+يعني انخفض العدد إلى بالفعل عدد كبير جدا طبعا
+
+517
+00:38:20,430 --> 00:38:27,570
+فكروا فيهابلاد ترانسفيوجين هو modern procedures
+
+518
+00:38:27,570 --> 00:38:29,530
+يعني قبل مائة سنة ماكانش في حد اسمها blood
+
+519
+00:38:29,530 --> 00:38:32,550
+transfusion ولا كان فيه ناجل دم، ماكانش فيه ناجل
+
+520
+00:38:32,550 --> 00:38:37,590
+دم، there must be another natural route of
+
+521
+00:38:37,590 --> 00:38:42,280
+transmissionيعني الاصل إنه نقل الدم مش هو الأساس
+
+522
+00:38:42,280 --> 00:38:45,280
+في عملية مين اللي هو نقل اللي هو ال .. ال ..
+
+523
+00:38:45,280 --> 00:38:48,680
+الفيروس لأنه هو قولنا عنه recent procedures أو
+
+524
+00:38:48,680 --> 00:38:51,680
+medical procedures it is likely that sexual
+
+525
+00:38:51,680 --> 00:38:55,140
+transmission and transmission from mother to child
+
+526
+00:38:55,140 --> 00:38:58,320
+during birth or breast feeding are the natural
+
+527
+00:38:58,320 --> 00:39:01,860
+route يبقى الأساس في الانتقال هو sexual
+
+528
+00:39:01,860 --> 00:39:08,450
+transmissionانفلوفت فيروس مثل HPV خدوا بالك هذا
+
+529
+00:39:08,450 --> 00:39:13,480
+بنقول اننا بنتقل عن طريق الدموبينتقل عن طريق الـ
+
+530
+00:39:13,480 --> 00:39:16,900
+Sexual Intercourse وبينتقل عن طريق مين؟ اللي هو
+
+531
+00:39:16,900 --> 00:39:21,520
+الـ M إلى المولود بينما Hepatitis C الانتقال
+
+532
+00:39:21,520 --> 00:39:26,780
+الرئيسي تبعه عبر الدم عبر الدم و الانتقال ممكن ..
+
+533
+00:39:26,780 --> 00:39:29,080
+ممكن يعني في بعض الدراسات بيقولوا انه ممكن ينتقل
+
+534
+00:39:29,080 --> 00:39:33,100
+لكن الكثاءة تبعته في الانتقال عبر ال Sexual
+
+535
+00:39:33,100 --> 00:39:37,160
+Intercourse او عبر ال mother to fetus هي ضعيفة جدا
+
+536
+00:39:37,160 --> 00:39:41,890
+إذا ال main هي ال C طبعاما دام C بينتقل عن طريق
+
+537
+00:39:41,890 --> 00:39:48,430
+الدم ليش منتشر عندنا بشكل .. في مصر ال hepatitis C
+
+538
+00:39:48,430 --> 00:39:52,410
+يعني يمكن يكون وعود انتخابية يعني لما انا اش هترشح
+
+539
+00:39:52,410 --> 00:39:54,350
+ل .. لرئاسة في مصر لازم اقولهم انا ابدا احاول
+
+540
+00:39:54,350 --> 00:39:59,650
+مشكلة منين؟ hepatitis C لأنه مشكلة كبيرة جدا لأنه
+
+541
+00:39:59,650 --> 00:40:05,190
+دم لأنه دم ويمكن يكون كمان كلمة دم يعني blood
+
+542
+00:40:05,190 --> 00:40:08,270
+translation ومافيش testing كويس او ممكن يكون فيه
+
+543
+00:40:08,270 --> 00:40:14,260
+practicesانتشار مخدرات او عدم الحلاجين الشفرات
+
+544
+00:40:14,260 --> 00:40:16,380
+بتاعتهم اطباء الأسنان اللي بيخلوا يبقوا يبقوا
+
+545
+00:40:16,380 --> 00:40:17,160
+يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا
+
+546
+00:40:17,160 --> 00:40:17,960
+يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا
+
+547
+00:40:17,960 --> 00:40:23,200
+يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا
+
+548
+00:40:23,200 --> 00:40:23,520
+يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا
+
+549
+00:40:23,520 --> 00:40:24,020
+يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا يبقوا
+
+550
+00:40:24,020 --> 00:40:30,740
+يبقوا يبقوا يبقوا يبقوا
+
+551
+00:40:31,790 --> 00:40:35,430
+مرضان اللي طلعوا يعملوا عمليات في مصر رجعونا ب
+
+552
+00:40:35,430 --> 00:40:39,010
+Hepatitis A وC والغريب في الأمر أن الفحص متوفر من
+
+553
+00:40:39,010 --> 00:40:42,370
+زمان بجديد يعني الفحص لل Hepatitis C فانا أصلا
+
+554
+00:40:42,370 --> 00:40:47,870
+استغرب لماذا لهذه اللحظة المشكلة قايمة و لما نتكلم
+
+555
+00:40:47,870 --> 00:40:50,830
+عن مصر احنا بتتكلم عن 100 مليون انسان 100 مليون
+
+556
+00:40:50,830 --> 00:40:54,700
+انسانلما تكون النسبة فيهم تلاتة في المية، خمسة في
+
+557
+00:40:54,700 --> 00:40:57,600
+المية أو عشرة في المية، هذا رقم ايه؟ رقم ضخم، يعني
+
+558
+00:40:57,600 --> 00:41:01,600
+بيشكل عبق على المرضى نفسهم وعلى الحكومة .. على
+
+559
+00:41:01,600 --> 00:41:05,620
+الحكومة أيضا فلو استثمروا في جانب ال prevention،
+
+560
+00:41:05,620 --> 00:41:08,700
+أنا متأكد انه خلال فترة و جزء لان هم بيستخدموا
+
+561
+00:41:08,700 --> 00:41:12,180
+عقارة موسوفالدي، عقارة موسوفالدي، very expensive
+
+562
+00:41:14,270 --> 00:41:17,330
+Effective treatment لليبادعي الـ C لكن very
+
+563
+00:41:17,330 --> 00:41:20,230
+expensive فلو استطبعوا هذه المبالغ أساسا او جزء
+
+564
+00:41:20,230 --> 00:41:23,790
+منها في ال prevention انا متأكد ان بعد فترة هيقعد
+
+565
+00:41:23,790 --> 00:41:29,910
+عليهم بالنفع بشكل كبير It is likely that sexual
+
+566
+00:41:29,910 --> 00:41:32,190
+transmission and transmission from mother to child
+
+567
+00:41:32,190 --> 00:41:34,930
+during birth or breast feeding are the natural
+
+568
+00:41:34,930 --> 00:41:41,670
+results هذا تخمينViruses such as HPV are more
+
+569
+00:41:41,670 --> 00:41:44,990
+sensitive to the environment than non-enveloped
+
+570
+00:41:44,990 --> 00:41:49,470
+viruses, and hence are more efficiently
+
+571
+00:41:49,470 --> 00:41:52,570
+transmitted by intimate contact.
+
+572
+00:41:56,170 --> 00:42:00,350
+Non-enveloped viruses such as HAV are quite stable
+
+573
+00:42:00,350 --> 00:42:04,570
+and are transmitted via the logical oral.
+
+574
+00:42:09,530 --> 00:42:15,150
+الهيباناتس بي فيروس موجود في كل العالم ولكنه موجود
+
+575
+00:42:15,150 --> 00:42:22,350
+في أسيا، يعني نسبة انتشاره أعلى في أسيا، طبعا
+
+576
+00:42:22,350 --> 00:42:31,100
+تتميزوا أن الجغرافيا قد لا تكون هي السببقد يكون
+
+577
+00:42:31,100 --> 00:42:35,300
+تطور البلدان اللي في تلك الجغرافية وعالم تطورها هو
+
+578
+00:42:35,300 --> 00:42:40,340
+السبب، الحالة الاقتصادية لتلك البلدان هي السبب
+
+579
+00:42:42,010 --> 00:42:47,170
+طلعوا على الأرقام الجاية Globally more than 300
+
+580
+00:42:47,170 --> 00:42:50,670
+million people are chronically infected عارفينش
+
+581
+00:42:50,670 --> 00:42:54,410
+يعني 300 مليون جربنا على ربع مليون او اكتر افن
+
+582
+00:42:54,410 --> 00:42:57,730
+جربنا على نص مليون مليار انسان chronically
+
+583
+00:42:57,730 --> 00:43:05,630
+infected with HPV and about 75% of them are Asians
+
+584
+00:43:05,630 --> 00:43:11,170
+يعني أسويينهناك احداث عالية لـHepatocellular
+
+585
+00:43:11,170 --> 00:43:13,790
+Carcinoma برضه هذه رابطناها مع بعض
+
+586
+00:43:13,790 --> 00:43:18,410
+الـHepatocellular Carcinoma سلطان الكبد اللي
+
+587
+00:43:18,410 --> 00:43:21,070
+بيسميه Hepatoma في العديد من البلدان الاسيانية
+
+588
+00:43:21,070 --> 00:43:25,110
+اجتماعات تشير إلى ان الـHPV ربما هو ورد من الفيروس
+
+589
+00:43:25,110 --> 00:43:28,210
+الهيومان تيومر لاننا نعرف ان في بعض الفيروسات
+
+590
+00:43:28,210 --> 00:43:31,910
+بيسميها Umko viruses وشوفنا بعض منها خلال دراستنا
+
+591
+00:43:31,910 --> 00:43:37,900
+السابقفبقول انه مادام فيه نسبة عالية من Hepatoma
+
+592
+00:43:37,900 --> 00:43:42,740
+وقد نعزوها لمين ل Hepatitis B يبقى Hepatitis B
+
+593
+00:43:42,740 --> 00:43:45,400
+ممكن ينصنف و احنا من مين من ال tumor virus
+
+594
+00:43:47,180 --> 00:43:51,420
+Immunization of against HPV in Taiwan وطيوان طبعا
+
+595
+00:43:51,420 --> 00:43:55,340
+ده دولة أسيوية من الدول المتقدمة مش من الدول
+
+596
+00:43:55,340 --> 00:44:00,320
+المتخلفة يعني ارتقت بشكل كبير وطيوان وصارت دولة
+
+597
+00:44:00,320 --> 00:44:04,620
+صناعية ومنتجة يعني للإلكترونيات والصناعات الكثيرة
+
+598
+00:44:04,620 --> 00:44:10,120
+فبتالي صار فيه تحسن كويس في نظام الصحي أكتر من
+
+599
+00:44:10,120 --> 00:44:11,360
+معظم الدول العربي
+
+600
+00:44:14,540 --> 00:44:18,120
+الـ الـ ال immunization لل HPV in Taiwan has
+
+601
+00:44:18,120 --> 00:44:21,260
+significantly reduced the incidence of Hepatoma in
+
+602
+00:44:21,260 --> 00:44:24,900
+children فاكرين لما كنا نتكلم عن ال Papillomavirus
+
+603
+00:44:24,900 --> 00:44:28,520
+ولا انستهوا؟ ال Papillomavirus كان برضه Oncogene،
+
+604
+00:44:28,520 --> 00:44:33,040
+مظبوط، وإن فيه strains منه بتعمل cervix cancer
+
+605
+00:44:33,940 --> 00:44:37,800
+وقلنا إنه عملنا vaccine وقلنا ال vaccine هذا يعني
+
+606
+00:44:37,800 --> 00:44:42,060
+against cancer لأنه بدا يحمينا من ال virus اللي
+
+607
+00:44:42,060 --> 00:44:45,480
+بيسبب ال cancer يبقى هنا عملنا vaccine ضد مين ضد
+
+608
+00:44:45,480 --> 00:44:49,800
+.. و .. و اعتبرنا انه the first لأن هناك منافسة له
+
+609
+00:44:49,800 --> 00:44:53,320
+في هذا المجال إذا افترضنا أن هناك بيمنع ال cancer
+
+610
+00:44:53,320 --> 00:44:57,100
+و هنا بيمنع ال cancer فالثانين الآن بيمنعوا ال
+
+611
+00:44:57,100 --> 00:45:01,200
+cancer it appears thatHPV vaccine is the first
+
+612
+00:45:01,200 --> 00:45:04,620
+vaccine to prevent a human cancer والحقيقة ان ال
+
+613
+00:45:04,620 --> 00:45:12,920
+HPV هذا HP هذا HPV vaccine كان قبل اللي هو ال
+
+614
+00:45:12,920 --> 00:45:15,700
+human papilloma virus vaccine المرة الجاية ان شاء
+
+615
+00:45:15,700 --> 00:45:18,460
+الله بنكمل ال pathogens و ال immunity و باقي
+
+616
+00:45:18,460 --> 00:45:19,060
+الفيروس
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/fH1r8SPi7gw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/fH1r8SPi7gw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b0f97d42d442ad88b7d1ab13d596b7c3ad42836e
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/fH1r8SPi7gw.srt
@@ -0,0 +1,2171 @@
+1
+00:00:21,240 --> 00:00:24,220
+بسم الله الرحمن الرحيم نبدأ إن شاء الله محاضرتنا
+
+2
+00:00:24,220 --> 00:00:29,220
+اليوم وهي استكمال الـ RNA انفلوفت فيروس وكنا قد
+
+3
+00:00:29,220 --> 00:00:35,020
+بدأنا بالحديث عن الكوكساكي فيروس أحد أهم مسببات الـ
+
+4
+00:00:35,020 --> 00:00:37,900
+meningitis أو الـ viral meningitis أو ما يعرف بالـ
+
+5
+00:00:37,900 --> 00:00:42,120
+aseptic meningitis هو والـ eco virus بالإضافة إلى
+
+6
+00:00:42,120 --> 00:00:46,780
+الـ mumps virus كنا قديمًا والآن أقل من ذي قبل بسبب
+
+7
+00:00:46,780 --> 00:00:51,230
+وجود اللي هو الـ vaccine  الكوكساكي بقى ذكرنا أنه سمي 
+
+8
+00:00:51,230 --> 00:00:53,670
+على اسم المدينة اللي شُوفت فيه هي فيه مدينة في نيو
+
+9
+00:00:53,670 --> 00:00:59,410
+يورك كوكساكي المرض بسبب الحقيقة أنه مجموعة من 
+
+10
+00:00:59,410 --> 00:01:03,160
+الأمراض سميناهم group A و group B والتصنيف group A
+
+11
+00:01:03,160 --> 00:01:06,020
+أو group B كان بناء على الأمراض اللي بيحدثها في
+
+12
+00:01:06,020 --> 00:01:10,360
+الفقران بيحدثها في الفقران لكن الأمراض اللي مذكورة
+
+13
+00:01:10,360 --> 00:01:14,560
+أمامنا هنا في اللوحة هذه هي أمراض للإنسان زي الـ
+
+14
+00:01:14,560 --> 00:01:17,600
+herpangina قلنا لك وهي عبارة عن mouth blisters
+
+15
+00:01:17,600 --> 00:01:21,080
+اللي هي الحويصلات اللي بتكون موجودة في أو بثرات
+
+16
+00:01:21,080 --> 00:01:24,160
+موجودة في الفم و acute hemorrhagic conjunctivitis
+
+17
+00:01:24,160 --> 00:01:29,630
+اللي هي التهاب ملتحمة العين الناس فيه بالإضافة إلى
+
+18
+00:01:29,630 --> 00:01:32,870
+المرض المعروف ومشهور اسمه hand, foot and mouth
+
+19
+00:01:32,870 --> 00:01:36,010
+disease بينما group B بتسبب مجموعة من الأمراض
+
+20
+00:01:36,010 --> 00:01:40,050
+أهمها pleurodynia اللي جينا عنها عبارة عن ألم في
+
+21
+00:01:40,050 --> 00:01:43,590
+بين العضلات اللي موجودة في الـ ribs أو في الحجاب
+
+22
+00:01:43,590 --> 00:01:48,430
+الحاجز بالإضافة إلى myocarditis and pericarditis
+
+23
+00:01:49,620 --> 00:01:53,820
+لكن اتفقنا أن كلا هما هدول الأمراض المميزة لكل
+
+24
+00:01:53,820 --> 00:01:57,460
+واحد من الثانية لكن كلا هما بيسبب اللي هي aseptic
+
+25
+00:01:57,460 --> 00:02:02,380
+meningitis فهي common disease between الاثنين وأنا
+
+26
+00:02:02,380 --> 00:02:06,400
+ذكرت لسه قبل ثواني أن التصنيف بيتم عن طريق اللي هو
+
+27
+00:02:06,400 --> 00:02:11,860
+الـ pathogenicity في الفقران group A بتسبب myositis
+
+28
+00:02:11,860 --> 00:02:17,400
+و flaccid paralysis which is rapidly fatal قاتل و
+
+29
+00:02:17,400 --> 00:02:21,540
+rapidly معناها بشكل سريع بينما group B causes
+
+30
+00:02:21,540 --> 00:02:25,100
+generalized less severe lesions on the heart طبعًا
+
+31
+00:02:25,100 --> 00:02:28,420
+myositis اللي هي الالتهابات في العضلة الالتهابات عضلة
+
+32
+00:02:28,420 --> 00:02:34,200
+القلب نفسها group B أيضًا بتسبب أقل حدة في عضلة
+
+33
+00:02:34,200 --> 00:02:37,040
+القلب لكن بتأثر على البنكرياس وعلى central
+
+34
+00:02:37,040 --> 00:02:41,900
+nervous system وبتعمل focal myositis myositis
+
+35
+00:02:41,900 --> 00:02:47,140
+focal معناها أنه بشكل نقاط مركزة في أماكن مختلفة
+
+36
+00:02:47,140 --> 00:02:51,370
+من عضلة القلب طلعوا على group A و group B الـ
+
+37
+00:02:51,370 --> 00:02:55,290
+serotypes تبعهم جدًّاش أن حوالي 24 serotypes من
+
+38
+00:02:55,290 --> 00:02:59,510
+كوكساكي virus A وحوالي 6 serotypes من كوكساكي
+
+39
+00:02:59,510 --> 00:03:04,410
+group B الـ Size والـ Structure والتركيب الداخلي
+
+40
+00:03:04,410 --> 00:03:10,130
+للفيروس يشبه بشكل كبير اللي هم الـ polyovirus وهذا
+
+41
+00:03:10,130 --> 00:03:13,050
+الكلام أيضًا ينطبق على الـ eco virus لما ندرسه هلاّج
+
+42
+00:03:13,050 --> 00:03:18,030
+أنه في الشكل بيشبه إلى حد كبير الـ polyovirus ليش؟
+
+43
+00:03:18,030 --> 00:03:20,530
+كلهم enteric virus
+
+44
+00:03:22,530 --> 00:03:25,010
+الـ poliovirus إحنا قلنا أنه بيعمل infection
+
+45
+00:03:25,010 --> 00:03:27,770
+فقط للـ higher primates الـ higher primates منهم
+
+46
+00:03:27,770 --> 00:03:31,610
+الإنسان قلنا والقرود تمام أو القرود العليا حتى مش 
+
+47
+00:03:31,610 --> 00:03:35,670
+القرود كلها إتها بينما الـ ... الـ كوكساكي فيروس
+
+48
+00:03:35,670 --> 00:03:38,410
+بيعمل infection للـ mammals other than primates
+
+49
+00:03:38,410 --> 00:03:43,030
+يعني لكل ثدييات أو بيعمل ثدييات أخرى غير الـ primate
+
+50
+00:03:43,030 --> 00:03:46,450
+لأن الـ primate أصلاً هي ثدييات فيضعف إلى ثدييات
+
+51
+00:03:46,450 --> 00:03:50,330
+أخرى يبقى هو أوسع في اللي هو الـ coverage تبعت الـ
+
+52
+00:03:50,330 --> 00:03:55,790
+host الكوكساكي فيروس بينتقل عبر طريقين في كال oral
+
+53
+00:03:55,790 --> 00:03:59,850
+transmission لأنه إنتريك فيروس لكن يعتقد أن الـ
+
+54
+00:03:59,850 --> 00:04:03,050
+respiratory aerosols برضه بتلعب دور في انتقال
+
+55
+00:04:04,300 --> 00:04:06,620
+التكاثر تبقى بتم في الـ Oropharynx والـ
+
+56
+00:04:06,620 --> 00:04:10,180
+Intestinal tract ولو الجملة هذه حد من اللي عندهم
+
+57
+00:04:10,180 --> 00:04:14,580
+photo memory ذاكرة ضوئية هيتذكر أن هي نفس الجملة
+
+58
+00:04:14,580 --> 00:04:18,300
+ذكرناها لمين؟ للـ Polio virus they replicate in the
+
+59
+00:04:18,300 --> 00:04:22,420
+Oropharynx and Intestinal tract ونفس الجملة أيضًا
+
+60
+00:04:22,420 --> 00:04:26,360
+اللي وراها Coxsackievirus Polio virus infected a
+
+61
+00:04:26,360 --> 00:04:31,670
+car worldwide worldwide primarily in summer and
+
+62
+00:04:31,670 --> 00:04:36,570
+fall برضه الجملة أو نفس العبارة
+
+63
+00:04:36,570 --> 00:04:41,510
+فيه ميل لجوة أن group A viruses تميل إلى أن تعمل
+
+64
+00:04:41,510 --> 00:04:44,930
+infection when في الـ skin والـ mucous membrane
+
+65
+00:04:44,930 --> 00:04:49,110
+بينما group B مالهاش تخصص ممكن تعمل infection in
+
+66
+00:04:49,110 --> 00:04:53,270
+other أو in many several organs زي الـ heart والـ
+
+67
+00:04:53,270 --> 00:04:56,510
+pleura والـ pancreas and liver هي بيعمل liver
+
+68
+00:04:56,510 --> 00:04:59,490
+infection لكن محاطنش مع من؟ مع الـ liver disease
+
+69
+00:04:59,490 --> 00:05:03,930
+لأنه بيعمل infection لـ other organs كمان مرة بنؤكد
+
+70
+00:05:03,930 --> 00:05:07,510
+على حقيقة أن both group A و group B can affect the
+
+71
+00:05:07,510 --> 00:05:10,750
+meninges and the motor neuron to cause paralysis
+
+72
+00:05:11,710 --> 00:05:15,850
+وهذا complication خطير جدًا في الـ aseptic
+
+73
+00:05:15,850 --> 00:05:18,470
+meningitis اللي إحنا قلنا عنها دائمًا أو معظم
+
+74
+00:05:18,470 --> 00:05:22,570
+حالاتها بتكون self-limited يعني الشفاء بدون أي
+
+75
+00:05:22,570 --> 00:05:26,370
+complication لكن أن في نسبة بسيطة جدًا قد يتطور
+
+76
+00:05:26,370 --> 00:05:30,110
+الأمر إلى أما paralysis اللي هو ارتخاء عضلات أو
+
+77
+00:05:30,110 --> 00:05:33,510
+paralysis أو of flaccid paralysis على غرار الـ
+
+78
+00:05:33,510 --> 00:05:38,170
+polyomyelitis from their original site of
+
+79
+00:05:38,170 --> 00:05:40,570
+replication in the oropharynx and gastrointestinal
+
+80
+00:05:40,570 --> 00:05:44,290
+tract they disseminate via the bloodstream إذا الـ
+
+81
+00:05:44,290 --> 00:05:50,010
+dissemination من خلال فيرميا الآن لحظة وملاحظة
+
+82
+00:05:50,010 --> 00:05:53,610
+أرجو أنكم راحتوها المرة الماضية في الـ polio وفي الـ
+
+83
+00:05:53,610 --> 00:05:57,790
+polio وأن الـ immunity ناتجة عن شغلتين خاصة لما تكون
+
+84
+00:05:57,790 --> 00:06:01,330
+natural infection أو الـ vaccine live attenuated
+
+85
+00:06:02,100 --> 00:06:04,720
+ذكرنا أنه في الـ live attenuated أو في الـ natural
+
+86
+00:06:04,720 --> 00:06:10,020
+في عندي IgA وفي عندي IgG ولم أتحدث عن الـ cell
+
+87
+00:06:10,020 --> 00:06:15,760
+mediated immunity صح لم صح يعني ما أبرزناش كل مرة
+
+88
+00:06:15,760 --> 00:06:18,720
+في الـ viral disease بنقول cell mediated immunity
+
+89
+00:06:18,720 --> 00:06:24,040
+لكن هنا هي هذه المرة وفي الـ polio لم نتحدث عن cell
+
+90
+00:06:24,040 --> 00:06:27,240
+mediated immunity تعرفوا ليش؟ الدرر في الـ polio
+
+91
+00:06:27,240 --> 00:06:30,200
+وين؟ هل في تكاثر في الأمعاء ولا في تكاثر في
+
+92
+00:06:30,200 --> 00:06:34,490
+central nervous system؟ فالمدان فيه stage viremia
+
+93
+00:06:34,490 --> 00:06:40,070
+يعني الفيروس موجود في الدم فالـ IGG لو جد يعمل
+
+94
+00:06:40,070 --> 00:06:43,590
+neutralization انتهى الموضوع وما في أي ضرر من هذا
+
+95
+00:06:43,590 --> 00:06:47,530
+الفيروس فكلا هنا سواء كان في الـ polio أو هنا الـ
+
+96
+00:06:47,530 --> 00:06:53,790
+IgG بيلعب دور كبير طب الـ IgA بيلعب دور كبير أيضًا
+
+97
+00:06:53,790 --> 00:06:57,530
+في مين؟ في الـ polio ما قلناش أنا في هذه الحالة ليش
+
+98
+00:06:57,530 --> 00:07:02,230
+في الـ polio؟ فكده لما قلت أنا عملت مناقشة ما بين الـ
+
+99
+00:07:02,230 --> 00:07:06,570
+live والـ attenuated والـ killed لما قلت أنه
+
+100
+00:07:06,570 --> 00:07:10,510
+الاثنين بيحموا الشخص من الإصابة بالـ polio اتفقنا
+
+101
+00:07:10,510 --> 00:07:14,170
+عليها صح اللي وراها أطول كان في جملة بتقول أنه can
+
+102
+00:07:14,170 --> 00:07:18,110
+prevent transmission الـ killed ما بيمنعكش لـ
+
+103
+00:07:18,110 --> 00:07:21,910
+transmission بينما الـ live attenuated كان بيمنع لـ
+
+104
+00:07:21,910 --> 00:07:26,770
+transmission السبب مين؟ موجود IgA في الـ live بس
+
+105
+00:07:26,770 --> 00:07:30,980
+عدم وجوده في مين؟ في الـ Killed Vaccine، إذن واضح
+
+106
+00:07:30,980 --> 00:07:35,440
+أن الـ IgG يلعب دورًا مهمة سواء كان في الكوكساكي
+
+107
+00:07:35,440 --> 00:07:37,120
+فيروس أو في الـ Polio Virus
+
+108
+00:07:39,720 --> 00:07:44,980
+توضيح أكثر لجروب A كلهم ذكرناهم الصحيح لكن تكرار
+
+109
+00:07:44,980 --> 00:07:49,840
+مفيد للتعلم Herpangina is characterized by fever,
+
+110
+00:07:50,120 --> 00:07:52,940
+sore throat, and tender vesicles tender معناها مؤلم،
+
+111
+00:07:52,940 --> 00:07:55,580
+vesicles اللي هي الحويصلات اللي بتكون موجودة
+
+112
+00:07:55,580 --> 00:08:00,200
+في الفم in the oropharynx الموضوع الثاني اللي
+
+113
+00:08:00,200 --> 00:08:04,560
+قلنا له عنه hand, foot and mouth disease وقلنا له
+
+114
+00:08:04,560 --> 00:08:07,700
+فيه على غراره في animal disease اسمه foot and
+
+115
+00:08:07,700 --> 00:08:13,660
+mouth disease اللي ... اللي اسمه الحمى القلاعية
+
+116
+00:08:13,660 --> 00:08:16,580
+حمى القلاعية اللي هو العربية بس هو بالإنجليزي اسمه
+
+117
+00:08:16,580 --> 00:08:19,860
+foot and mouth disease طبعًا بيصيب الحيوانات هذا
+
+118
+00:08:19,860 --> 00:08:25,030
+بيصيب اللي هو الإنسان طبعًا المشترك أنه foot and
+
+119
+00:08:25,030 --> 00:08:27,670
+mouth وهنا فيه foot and mouth مظبوط أو لأ بس لأن
+
+120
+00:08:27,670 --> 00:08:30,970
+الحيوانات اللي هتعملها بنسميها hands كله foot ولأ
+
+121
+00:08:30,970 --> 00:08:37,610
+فبالتالي إحنا عندنا hand و foot والـ mouth اللي
+
+122
+00:08:37,610 --> 00:08:40,530
+ذكرناه على الـ alteration في الـ herpangina بيكون
+
+123
+00:08:40,530 --> 00:08:43,110
+منتشرة في الأيدي ومنتشرة في الرجلين ومنتشرة كمان
+
+124
+00:08:43,110 --> 00:08:47,650
+أيضًا في الفم بينما جروب B specific diseases
+
+125
+00:08:47,650 --> 00:08:50,770
+pleurodynia وقلنا على الكويشياني pleurodynia هي
+
+126
+00:08:50,770 --> 00:08:55,510
+عبارة عن ألم في العضلات ما بين الأضلاع أو في منطقة
+
+127
+00:08:55,510 --> 00:09:00,010
+الحجاب الحاجز وسموها devil's grip قبضة الشيطان
+
+128
+00:09:00,010 --> 00:09:04,170
+يعني لو كان الشيطان ضغط عليه اللي هو صدر الإنسان
+
+129
+00:09:04,170 --> 00:09:10,420
+اللي هو المريض فيه myocarditis و pericarditis دول
+
+130
+00:09:10,420 --> 00:09:14,400
+برضه مرضين مهمين جدا في هذا الفيروس لكن في خوف
+
+131
+00:09:14,400 --> 00:09:18,880
+وخشية دائما لما يكون المريض مصاب بـ group B
+
+132
+00:09:18,880 --> 00:09:23,600
+specific Coxsackievirus أن يتطور لحزمة dilated
+
+133
+00:09:23,600 --> 00:09:30,600
+cardiomyopathy وهذه الـ .. ايش بقى dilated؟ متوسعة
+
+134
+00:09:30,600 --> 00:09:34,740
+متمددة Cardiomyopathy يعني عضلة القلب نفسها يصير
+
+135
+00:09:34,740 --> 00:09:38,260
+فيها إيه نوع من التمدد هذه بنقدر نقول أنه
+
+136
+00:09:38,260 --> 00:09:45,280
+complications يخشى من حدوثها لأنها ستؤدي بالدرجة
+
+137
+00:09:45,280 --> 00:09:50,260
+الأولى إلى أنه لابد من نقل القلب لهذا المريض يعني
+
+138
+00:09:50,260 --> 00:09:55,240
+عضلة القلب بيصير ضعيفة جدا وبالتالي لن تؤدي 
+
+139
+00:09:55,240 --> 00:10:00,920
+وظيفتها لازم يكون في هذه الحالة استبدال للقلب للمرض
+
+140
+00:10:00,920 --> 00:10:04,980
+الرابع في الفئران بس هذا ما دعاه أن نفكر كويس في
+
+141
+00:10:04,980 --> 00:10:09,720
+الأمراض اللي كنا بنفكرها يعني بأسباب أخرى زي الـ
+
+142
+00:10:09,720 --> 00:10:14,040
+diabetes الـ diabetes ثبت أن هذا الفيروس بيعمل
+
+143
+00:10:14,040 --> 00:10:20,220
+diabetes في الفئران وفي بعض الدراسات لمحت إلى دور
+
+144
+00:10:20,220 --> 00:10:24,020
+محتمل إلى هذا الفيروس في الـ diabetes سبعة الأطفال
+
+145
+00:10:24,020 --> 00:10:29,350
+اللي بيسموها juvenile diabetes وبالتالي هذا شكل أول
+
+146
+00:10:29,350 --> 00:10:33,530
+proof أن ممكن .. ممكن الـ diabetes تكون caused by
+
+147
+00:10:33,530 --> 00:10:37,350
+viral infection ممكن يكون سبب من الأسباب لكن مش
+
+148
+00:10:37,350 --> 00:10:44,670
+متأكدين احنا مائة بالمئة الـ clinical finding ما
+
+149
+00:10:44,670 --> 00:10:47,510
+زلنا فيها احنا كنا بنتكلم عن group A و group B
+
+150
+00:10:47,510 --> 00:10:50,950
+والآن بنتكلم عن diseases caused by both group يعني
+
+151
+00:10:50,950 --> 00:10:55,320
+حاجة common بين الاثنين الاثنين أول حاجة هنشوفها كمان إيش
+
+152
+00:10:55,320 --> 00:10:59,420
+هي؟ aseptic meningitis وقلنا mild وParesis وقلنا
+
+153
+00:10:59,420 --> 00:11:03,460
+لكم Paresis معناها ارتخاء في العضلات بينما الـ
+
+154
+00:11:03,460 --> 00:11:07,420
+acute flaccid paralysis هو similar to مين to polio
+
+155
+00:11:07,420 --> 00:11:11,960
+myelitis وهو شلل ارتخائي يشبه قلنا كمان مرة شلل
+
+156
+00:11:11,960 --> 00:11:16,360
+الأطفال أيضا هناك إمكانية حدوث upper respiratory
+
+157
+00:11:16,360 --> 00:11:19,520
+infection and minor febrile illness إيش يعني
+
+158
+00:11:19,520 --> 00:11:23,620
+febrile؟ يعني في ارتفاع في درجة الحرارة يعني سخونة
+
+159
+00:11:23,620 --> 00:11:28,340
+تمام؟ المرض فيه سخونة with or without rash عارفين
+
+160
+00:11:28,340 --> 00:11:32,520
+شنير؟ rash كثير من الناس بعد الحرارة بعدما ترتفع
+
+161
+00:11:32,520 --> 00:11:36,680
+حرارته ممكن يظهر عليه طفح جلدي can also occur إذن
+
+162
+00:11:36,680 --> 00:11:41,280
+باختصار الـ group A و الـ group B بيختلفوا عن بعض في
+
+163
+00:11:41,280 --> 00:11:44,360
+الأمراض لكن في أمراض أو أعراض بالأحرى خلينا نسميها
+
+164
+00:11:44,360 --> 00:11:50,000
+مشتركة بين الاثنين الـ lab diagnosis بيتلخص في أنه
+
+165
+00:11:50,000 --> 00:11:54,540
+نعزل الفيروس في cell culture أو نعزله في فئران
+
+166
+00:11:54,540 --> 00:11:58,160
+بترضع، فئران يعني لسه صغيرة، suckling mice
+
+167
+00:11:58,160 --> 00:12:01,900
+بيسموها، هذه فئران صغيرة، أنتم فاكرين قبل شوية
+
+168
+00:12:01,900 --> 00:12:04,740
+لما صار التصنيف، وأين تم التصنيف؟ group A و group
+
+169
+00:12:04,740 --> 00:12:09,660
+B على الأعمار اللي تحدثنا فيه الفئران؟ كمان في
+
+170
+00:12:09,660 --> 00:12:12,480
+rise in title of neutralizing antibodies، اللي هي
+
+171
+00:12:12,480 --> 00:12:18,950
+الـ IgG لكن في فحص أهم من الأول والثاني وهو الـ PCR
+
+172
+00:12:18,950 --> 00:12:22,290
+based test وهو rapid test رابيد test يعني خلال
+
+173
+00:12:22,290 --> 00:12:25,270
+ساعتين ونصف زي ما احنا ذاكرينه على اللوحة ساعتين و
+
+174
+00:12:25,270 --> 00:12:29,130
+نصف بنكشف فيه عن الـ enteroviral RNA في الـ spinal
+
+175
+00:12:29,130 --> 00:12:34,380
+fluid وهذا يعني بيساعدنا جدا في تشخيص الـ Aseptic
+
+176
+00:12:34,380 --> 00:12:38,520
+meningitis caused by Koksaki virus كمان مرة أؤكد
+
+177
+00:12:38,520 --> 00:12:43,660
+لكم أن هذه الفحوصات سهلة وميسرة وغير مكلفة لكنها
+
+178
+00:12:43,660 --> 00:12:48,380
+غير متوفرة لأن مافيش إرادة لتوفيرها من قبل إما
+
+179
+00:12:48,380 --> 00:12:52,540
+العاملين في القطاع الصحي اللي هم الأطباء والتحاليل
+
+180
+00:12:52,540 --> 00:12:57,060
+أو أن النظام الصحي لسه مش مؤمن بأنه لابد من توفير
+
+181
+00:12:57,060 --> 00:13:00,720
+هذه الفحوصات بدل ما إرسالها تخيل عندهم لما تكونوا
+
+182
+00:13:00,720 --> 00:13:04,940
+عارفين أنه viral من البداية وعارفين إيش نوع الفيروس
+
+183
+00:13:04,940 --> 00:13:08,420
+بنكون مطمئنين للـ consequences مظبوط أو مش مظبوط
+
+184
+00:13:08,420 --> 00:13:12,760
+وبالتالي هذا بيوفر علينا تكلفة كبيرة دلوقت لحد دلوقت
+
+185
+00:13:12,760 --> 00:13:15,720
+هذا الكلام غير موجود treatment and prevention
+
+186
+00:13:15,720 --> 00:13:19,580
+there is neither antiviral drugs nor a vaccine
+
+187
+00:13:19,580 --> 00:13:22,160
+available against these viruses بنتكلم عن تلاتين
+
+188
+00:13:22,160 --> 00:13:27,140
+zero type جدش وأنا أربعة وعشرين تقريبا من A و
+
+189
+00:13:27,140 --> 00:13:32,070
+ستة من B فمجموعهم تلاتين zero types No passive
+
+190
+00:13:32,070 --> 00:13:35,750
+immunization is recommended وهذا يعني أنه تم تجريب
+
+191
+00:13:35,750 --> 00:13:40,850
+إعطاء immunoglobulin ولم تكن له فائدة في تغيير الـ
+
+192
+00:13:40,850 --> 00:13:44,310
+course تبع المرض أو في تحسين الـ outcomes تبعت اللي
+
+193
+00:13:44,310 --> 00:13:51,010
+هي الـ disease الفيروس الثاني أخوه Ecovirus ما زلنا
+
+194
+00:13:51,010 --> 00:13:53,310
+احنا فيه مين الآن؟ في الـ enterovirus بسبب أن
+
+195
+00:13:53,310 --> 00:13:57,890
+الـ enterovirus فينا بوليو وفي عندنا كوكساكي وعندنا
+
+196
+00:13:57,890 --> 00:14:02,510
+الـ Eco وعندنا Hepatitis A طبعا في غيرهم بس احنا
+
+197
+00:14:02,510 --> 00:14:08,790
+مركزين على هدول المجموعة أكثر شيء Ecovirus الـ Eco
+
+198
+00:14:08,790 --> 00:14:14,570
+مأخوذة الأربع أحرف تبعتهم مأخوذة من أربع كلمات
+
+199
+00:14:22,320 --> 00:14:24,160
+Orphan معناها بنت يتيم
+
+200
+00:14:28,840 --> 00:14:32,440
+الآن كلمة يتيم هنا المقصود فيها إيه يا شباب؟ أنه
+
+201
+00:14:32,440 --> 00:14:38,220
+أول ما عزل .. أول ما عزل لم نجد له مرض محدد يعني
+
+202
+00:14:38,220 --> 00:14:42,440
+كنا نفكر أنه مسكين .. مسكين فيروس بس ما بيعملش
+
+203
+00:14:42,440 --> 00:14:47,700
+إيه؟ امرض في حينها فسموه orphan الآن من خصائصه
+
+204
+00:14:47,700 --> 00:14:50,080
+أنه انترك بيعمل psychopathic effect وبيعمل
+
+205
+00:14:50,080 --> 00:14:54,050
+infection لمين؟ للإنسان فسموه Enteric Cytopathic
+
+206
+00:14:54,050 --> 00:14:57,950
+Human Orphan وبعدين هنضلنا اسم طويل اختصرناه بـ Eco
+
+207
+00:14:57,950 --> 00:15:01,510
+Virus لأن لو سألتوا معظم الناس اللي بيشتغلوا في
+
+208
+00:15:01,510 --> 00:15:04,250
+هذا المجال إيش يعني Eco Virus بيعرفش لأنه خلاص هو
+
+209
+00:15:04,250 --> 00:15:09,850
+الـ Eco هو الاسم الأشهر زي اللقب لبعض الأحيان بيغلب
+
+210
+00:15:09,850 --> 00:15:14,130
+على اللي هو الاسم الحقيقي تخيلوا لو في يوم من
+
+211
+00:15:14,130 --> 00:15:17,050
+الأيام أنكم أنا قلت لصديق مثلا صديق أعرفه من
+
+212
+00:15:17,050 --> 00:15:19,830
+عشرين سنة وثلاثين سنة مرة سألني عنه واحد قولي كيف
+
+213
+00:15:19,830 --> 00:15:28,950
+لأن باسمه الأول مين فلان؟ فلان وكان بالفعل بصعوبة
+
+214
+00:15:28,950 --> 00:15:32,890
+أنه أنا يعني لما ذكر اللقب بعدين أنا تذكرت اللي
+
+215
+00:15:32,890 --> 00:15:35,830
+هو بتتكلم عن مين فهذه مشكلة كبيرة أن بعض الأحيان
+
+216
+00:15:35,830 --> 00:15:40,270
+بالفعل اللقب أو اسم الشهرة بيغلب على الاسم الحق فالـ
+
+217
+00:15:40,270 --> 00:15:44,330
+Echo هو الدارج لكن في الامتحان مطلوب منكم تعرفوا
+
+218
+00:15:44,330 --> 00:15:48,130
+صديقكم اللي هو الـ enteric cytopathic human orphan
+
+219
+00:15:50,900 --> 00:15:53,360
+causes a variety of diseases such as aseptic
+
+220
+00:15:53,360 --> 00:15:56,520
+meningitis, upper respiratory tract, infection,
+
+221
+00:15:56,920 --> 00:16:01,340
+febrile, illness with or without rash بما
+
+222
+00:16:01,340 --> 00:16:03,840
+الطفل ده يعني هذه الكلمة مرفوضة في الـ Coxsackie
+
+223
+00:16:03,840 --> 00:16:08,180
+فيروس يعني هو بيشترك معاه في كثير من الأمور منها
+
+224
+00:16:08,180 --> 00:16:10,400
+الـ Febrile Illness اللي كنا نقول عنه قبل قليل
+
+225
+00:16:10,400 --> 00:16:14,440
+اللي with or without rashes لكن ما بيشتركش معاه في
+
+226
+00:16:14,440 --> 00:16:18,560
+الطفل داء الإسهال بيتميز عنه في الطفل داء الإسهال
+
+227
+00:16:18,560 --> 00:16:21,240
+وبيشترك معاه أيضا مرة ثانية في مين؟ في الـ
+
+228
+00:16:21,240 --> 00:16:24,820
+hemorrhagic conjunctivitis The structure of
+
+229
+00:16:24,820 --> 00:16:28,240
+Echovirus is similar to that of other enteric
+
+230
+00:16:28,240 --> 00:16:33,160
+virus أو enterovirus أكثر من ثلاثين serotype have
+
+231
+00:16:33,160 --> 00:16:38,780
+been isolated In contrast to Coxsackievirus they
+
+232
+00:16:38,780 --> 00:16:44,500
+are not part unique to mice يبقى بيختلف مع
+
+233
+00:16:44,500 --> 00:16:48,440
+Coxsackievirus بأنه بيعملش infection للميس و
+
+234
+00:16:48,440 --> 00:16:52,560
+unlike poliovirus they do not cause diseases in
+
+235
+00:16:52,560 --> 00:16:56,740
+monkeys هذا متخصص فينا احنا أكثر من ما هو متخصص في
+
+236
+00:16:56,740 --> 00:17:03,060
+أشياء أخرى عشان نسمينا احنا انتليك و human هي تتبع
+
+237
+00:17:03,060 --> 00:17:06,120
+من طريق الوصول الهوائي للعقل والعقلية والعقلية
+
+238
+00:17:06,120 --> 00:17:07,100
+والعقلية والعقلية والعقلية والعقلية والعقلية
+
+239
+00:17:07,100 --> 00:17:08,940
+والعقلية والعقلية والعقلية والعقلية والعقلية
+
+240
+00:17:08,940 --> 00:17:14,840
+والعقلية والعقلية والعقلية والعقلية والعقلية
+
+241
+00:17:14,840 --> 00:17:19,640
+والعقلية والعقلية والعقلية والعقلية والعقلية
+
+242
+00:17:19,640 --> 00:17:19,860
+والعقلية والعقلية والعقلية والعقلية والعقلية
+
+243
+00:17:19,860 --> 00:17:19,960
+والعقلية والعقلية والعقلية والعقلية والعقلية
+
+244
+00:17:19,960 --> 00:17:26,980
+والعقلية والعقلية والعقلية
+
+245
+00:17:26,980 --> 00:17:33,000
+والعديم الفائدة، عرفيه ليش عديم الفائدة؟ لأن الـ
+
+246
+00:17:33,000 --> 00:17:36,020
+Serotypes بتاعت الفيروس مافيش فيها common antigen
+
+247
+00:17:36,020 --> 00:17:40,320
+أقدر أكشف عنه وبالتالي لازم أكشف عنه عن جدش عن
+
+248
+00:17:40,320 --> 00:17:42,440
+ثلاثين وهذا الأمر يعني مش practical في أي
+
+249
+00:17:42,440 --> 00:17:45,640
+serological test في أي serological test كمان مافيش
+
+250
+00:17:45,640 --> 00:17:50,000
+antiviral therapy ومافيش أنه vaccine متاح لهذا 
+
+251
+00:17:50,000 --> 00:17:54,020
+الفيروس إذا أن أنا بقدر أقول أنه عندي Polio وعندي 
+
+252
+00:17:54,020 --> 00:17:58,990
+كمان؟ عندي Coxsackie virus وعندي Echovirus هدولة من
+
+253
+00:17:58,990 --> 00:18:02,860
+المشهور اللي هم الـ enteric viruses لكن هم ليسوا 
+
+254
+00:18:02,860 --> 00:18:07,060
+الوحيدين ليسوا الوحيدين other enteroviruses عندي
+
+255
+00:18:07,060 --> 00:18:10,440
+طبعا الـ enterovirus اللي اكتشفت بعد ذلك صارت تعطى
+
+256
+00:18:10,440 --> 00:18:14,580
+أرقام فعندي سبعين وواحد، سبعين واثنين، وسبعين البعض
+
+257
+00:18:14,580 --> 00:18:20,220
+منها يعني لما انشهر كثير أعطانا اسم غير الرقم زي
+
+258
+00:18:20,220 --> 00:18:23,840
+مثلا الأخير Hepatitis A هو كان اسمه زمان إيه؟
+
+259
+00:18:23,840 --> 00:18:28,020
+enterovirus seventy two طلعوا على سبعين وواحد
+
+260
+00:18:28,020 --> 00:18:32,940
+وسبعين  Enterovirus 70 is the main cause of acute
+
+261
+00:18:32,940 --> 00:18:37,800
+hemorrhagic conjunctivitis كلهم الاثنين الأولانيين 
+
+262
+00:18:37,800 --> 00:18:41,140
+كانوا عاملين acute hemorrhagic conjunctivitis وهي
+
+263
+00:18:41,140 --> 00:18:44,140
+الـ Enterovirus 70 بيعمل acute hemorrhagic
+
+264
+00:18:44,140 --> 00:18:47,980
+conjunctivitis في هذا المرض complete recovery
+
+265
+00:18:47,980 --> 00:18:52,560
+occurs يعني بيحدث شفاء تام and there is no
+
+266
+00:18:52,560 --> 00:18:57,400
+need for therapy لهذا الفيروس الآن الفيروس رقم
+
+267
+00:18:57,400 --> 00:19:01,610
+واحد وسبعين خطير صحي وهو واحد من أسباب أساسية
+
+268
+00:19:01,610 --> 00:19:05,730
+للنيربوس المركزي الواقعي وهو ميليندريتس وإنسفاليتس
+
+269
+00:19:05,730 --> 00:19:10,890
+وهذا الفيروس في يوم من الأيام هياخد اسم أيضا هياخد
+
+270
+00:19:10,890 --> 00:19:15,950
+اسم وهياخد اسم مشهور لأنه بدأ نجمه يلمع بشكل أكبر
+
+271
+00:19:15,950 --> 00:19:19,890
+ولما يكون نيربوس المركزي الواقعي فيروس لازم ياخد
+
+272
+00:19:19,890 --> 00:19:21,470
+اسم كويس
+
+273
+00:19:27,230 --> 00:19:33,390
+الفيروس الذي يعني يؤرق الجميع وكما ذكرت لكم في
+
+274
+00:19:33,390 --> 00:19:36,990
+أحد الكتب بكر أحد الكتاب أن البيت الإنجليزي يكون
+
+275
+00:19:36,990 --> 00:19:43,290
+من رجل وامرأة وكلب وفيروس الرشح طبعا وذكر كلمة
+
+276
+00:19:43,290 --> 00:19:49,490
+شتيمة مع اللعين لأنه كل كوب تعرفوا أنه في العام
+
+277
+00:19:49,490 --> 00:19:53,670
+الواحد قد يتعرض الإنسان الشخص الواحد إلى أكثر من
+
+278
+00:19:53,670 --> 00:19:57,950
+نوبة من نوبات اللي هو مرض الرشح طبعا أهم وسيلة
+
+279
+00:19:57,950 --> 00:20:01,110
+الرشح هو الـ rhinovirus طبعا بقولنا فيه other
+
+280
+00:20:01,110 --> 00:20:06,030
+viruses لكن هو الأكثر sure الـ disease these
+
+281
+00:20:06,030 --> 00:20:10,570
+viruses are the main cause of common cold أكثر من
+
+282
+00:20:10,570 --> 00:20:16,150
+مئة نوع وهذا السبب أن احنا بنمرض مرارا وتكراراذكرنا في مقدمة المحاضرات أن الـ replication
+
+283
+00:20:16,150 --> 00:20:21,480
+تبعه يتم على تلاتين درجة مئوية لذلك هو they
+
+284
+00:20:21,480 --> 00:20:25,500
+prefer الـ upper respiratory tract and they cannot
+
+285
+00:20:25,500 --> 00:20:28,980
+infect the lower respiratory أو الـ gastric tract
+
+286
+00:20:28,980 --> 00:20:32,880
+لأنه لبعيد الـ host sensitive لأس الهوست
+
+287
+00:20:32,880 --> 00:20:39,780
+range is limited to human and chimpanzees اللي هي
+
+288
+00:20:39,780 --> 00:20:43,260
+القرود الشمبانزي والإنسان فقط لغاية الـ
+
+289
+00:20:43,260 --> 00:20:48,160
+Transmission هناك يعني معروف عنه أنه فيه طريقتين
+
+290
+00:20:48,160 --> 00:20:50,720
+لـ Transmission واحدة بنسميها directly from person
+
+291
+00:20:50,720 --> 00:20:54,320
+to person by skin contact أو سلام أو غيره والثانية
+
+292
+00:20:54,320 --> 00:20:58,620
+by respiratory aerosols لكن هناك طريقة ثالثة يعتقد
+
+293
+00:21:04,180 --> 00:21:09,680
+أنها لا تقل أهمية عن الطريقة اللي ذكرناها إيش طريقة
+
+294
+00:21:09,680 --> 00:21:13,840
+ثالثة هذه؟ اللي هي الـ indirect، تمام؟ الـ indirect
+
+295
+00:21:13,840 --> 00:21:16,680
+هذا الـ surface اللي احنا قاعدين عليه هذا، كم واحد
+
+296
+00:21:16,680 --> 00:21:20,800
+عطي صمر جنبه، وصار فيه نوع من الـ deposition الـ
+
+297
+00:21:20,800 --> 00:21:24,460
+virus على الـ surface هذا، تذكروا أن هذا فيروس؟ non
+
+298
+00:21:24,460 --> 00:21:29,960
+-enveloped، يعني الـ stability تبعته عالية، تمام؟ الـ 
+
+299
+00:21:29,960 --> 00:21:34,180
+الـ الـ aerosol ما نشي هو يعني لا لا بس المصافحة
+
+300
+00:21:34,180 --> 00:21:37,640
+حينيا كان واحد مرشح اليوم في الفصل تمام؟ وبمسي الـ
+
+301
+00:21:37,640 --> 00:21:41,360
+clinics وبفكر حاجة من هنا إنه ما نزلش على أيديه
+
+302
+00:21:41,360 --> 00:21:45,360
+أي أي من هذه السواقل فهو عطس وغطى إيده وبعد
+
+303
+00:21:45,360 --> 00:21:49,260
+شوية قد حد ما ماتسلم عليه فبيسلم عليه فبينقل
+
+304
+00:21:49,260 --> 00:21:53,060
+منه برضه من اللي هو الـ الـ الـ virus لأن
+
+305
+00:21:53,060 --> 00:21:56,440
+المشكلة اللي بقولها indirect إنه من surfaces أو من
+
+306
+00:21:56,440 --> 00:22:04,010
+hands وبعدين لمين؟ finger to eye أو to nose طبعا
+
+307
+00:22:04,010 --> 00:22:06,910
+أنتوا مستغربين من الـ من الـ الكلمة finger to
+
+308
+00:22:06,910 --> 00:22:10,550
+eye و finger to nose بس الحقيقة أنه الـ finger to
+
+309
+00:22:10,550 --> 00:22:14,790
+eye واحدة من طرق العديدة لنقل الأمراض اللي من
+
+310
+00:22:14,790 --> 00:22:18,610
+ضمنها الرشح والإنفلونزا والـ other أيضا eye
+
+311
+00:22:18,610 --> 00:22:22,970
+diseases وبالتالي لو الواحد اضطر أنه يستخدم
+
+312
+00:22:22,970 --> 00:22:29,100
+الأصابع للحكة في موضوع هو مش لاسل إيديه لازم يعني
+
+313
+00:22:29,100 --> 00:22:34,980
+يستخدم إما ورق الـ clinics هذا أو إنه بمكان
+
+314
+00:22:34,980 --> 00:22:38,160
+آخر غير الأصابع اللي هم اللي بيمسكوه اللي هم
+
+315
+00:22:38,160 --> 00:22:42,640
+الأسطح وبالتالي هم الأكثر عرضة للتلوث ونقل هذا
+
+316
+00:22:42,640 --> 00:22:48,340
+إما إذا اتبعوا معناها finger to eye أو finger to
+
+317
+00:22:48,340 --> 00:22:55,480
+nose The common cold is reputed يعني سمعته to be
+
+318
+00:22:55,480 --> 00:22:58,680
+the most common human infection هو هي الأكثر أو
+
+319
+00:22:58,680 --> 00:23:02,560
+أكثر عدوى منتشرة بين البشر although that are
+
+320
+00:23:02,560 --> 00:23:06,120
+difficult to obtain because it is not well defined
+
+321
+00:23:06,120 --> 00:23:09,880
+or notifiable disease ما أحد فينا لما بيمرض بيرشح
+
+322
+00:23:09,880 --> 00:23:13,930
+بيروح على الطبيب ولا أقوم على الطبيب الدكتور
+
+323
+00:23:13,930 --> 00:23:17,430
+بيسجلش حالة وبيوضيها لوزارة الصحة بقولهم والله
+
+324
+00:23:17,430 --> 00:23:22,630
+عندي عشر حلقات رشح الـ disease mild وبالتالي هو مش
+
+325
+00:23:22,630 --> 00:23:28,010
+notifiable وأنا ذكرتلكوا إيش يعني notifiable يعني
+
+326
+00:23:28,010 --> 00:23:32,130
+reportable يعني أن أنا لازم أعمله reporting لأ مش
+
+327
+00:23:32,130 --> 00:23:35,790
+من الـ reporting وبالتالي ما عنديش أرقام دقيقة لكن
+
+328
+00:23:36,200 --> 00:23:39,900
+من انتشار الرشح ومن ملاحظات الناس بدون دراسات
+
+329
+00:23:39,900 --> 00:23:43,680
+الصمعة اللي طالعة على هذا الفيروس أن هو الأشهر أو
+
+330
+00:23:43,680 --> 00:23:49,210
+أكثر انتشارا بين البشر شوفوا كم يوم دراسي وكم
+
+331
+00:23:49,210 --> 00:23:54,470
+يوم عمل بيفقد في العالم سنويا كم مليون وأنا أقرب
+
+332
+00:23:54,470 --> 00:23:58,110
+مليون عمل لو أنا جبت يوم أنا بحسبه اليوم لو جبنا
+
+333
+00:23:58,110 --> 00:24:02,290
+عشرة هي عشرة أيام في يوم واحد في السنة الواحدة
+
+334
+00:24:02,290 --> 00:24:06,350
+بيطلعنا ملايين الأيام ملايين الأيام غياب عن المدارس
+
+335
+00:24:06,350 --> 00:24:09,890
+وعن العمل بسبب فيروس اللي هو الرشح
+
+337
+00:24:16,630 --> 00:24:20,330
+مؤذي جدا وفي بعض الناس وأنا منهم بعتبر الفيروس
+
+338
+00:24:20,330 --> 00:24:23,390
+الرشح من أسوأ الأمراض اللي ممكن تمر عليها طول
+
+339
+00:24:23,390 --> 00:24:27,530
+السنة يعني لأنه بيعمل generalized weakness يعني
+
+340
+00:24:27,530 --> 00:24:31,890
+ضعف عام في اللي هو الإنسان وبيعكن المزاج بشكل
+
+341
+00:24:31,890 --> 00:24:35,670
+كبير الأوقات
+
+342
+00:24:35,670 --> 00:24:41,270
+الأكثر يعني انتشارا فيها الفيروس هي غالبا الخريف
+
+343
+00:24:41,270 --> 00:24:45,330
+بالإضافة إلى الشتاء فصل الشتاء وطبعا ناقشنا قبل ذلك
+
+344
+00:24:45,330 --> 00:24:49,170
+احنا ليش فصل الشتاء بالذات كورونا كورونا بسبب الـ
+
+345
+00:24:49,170 --> 00:24:54,170
+crowdiness إغلاق الشرابيك وإيش كمان أن الـ stability
+
+346
+00:24:54,170 --> 00:25:00,010
+بتاعة الفيروس بتكون أطول في درجات الحرارة المنخفضة
+
+347
+00:25:02,570 --> 00:25:13,610
+السبب في هذا
+
+348
+00:25:13,610 --> 00:25:18,380
+التغيير الموسمي غير واضح لأنه لما قلنا لكوا احنا
+
+349
+00:25:18,380 --> 00:25:22,440
+ليش في الشتاء جيبو سيطرة وجيبو أسباب مظبوط وبعدين احنا ناقشنا السبب بين هدولة فبالتالي قولنا
+
+350
+00:25:22,440 --> 00:25:25,640
+أنه علميا احنا مش عارفين بالضبط إيش اللي بيصير في
+
+351
+00:25:25,640 --> 00:25:29,480
+الشتاء لكن بنحاول نفسر وزي ما ذكرنالكوا أهم
+
+352
+00:25:29,480 --> 00:25:34,100
+النقطتين كانوا مين crowding that occurs at schools
+
+353
+00:25:34,100 --> 00:25:38,500
+for example في المدارس بيصير في اللي هو الـ الـ
+
+354
+00:25:38,500 --> 00:25:42,960
+الازدحام وهذا الازدحام مع قلة التهوية هو اللي
+
+355
+00:25:42,960 --> 00:25:47,360
+بيساهم في عملية الانتشار تلعب على هذه a few
+
+356
+00:25:53,840 --> 00:25:57,600
+serotypes of rhinoviruses are prevalent during one
+
+357
+00:25:57,600 --> 00:26:01,100
+season only to be replaced by other serotypes
+
+358
+00:26:01,100 --> 00:26:04,220
+during the following season يعني لو جينا لو
+
+359
+00:26:04,220 --> 00:26:09,550
+جينا الفصل هذا الرشح اللي موجود بلفلف بين الناس
+
+360
+00:26:09,550 --> 00:26:15,570
+وأنا أفترض أنه Serotype XYOZ السنة الجاية غالبا مش
+
+361
+00:26:15,570 --> 00:26:20,290
+هم اللي بيكونوا موجودين عارفين ليش؟ عارفين ليش؟ لأن
+
+362
+00:26:20,290 --> 00:26:24,450
+احنا الـ population اللي السنة الماضية أصيبت لأن
+
+363
+00:26:24,450 --> 00:26:28,590
+صاروا immunized لـ X and Y and Z وكلمة immunized
+
+364
+00:26:28,590 --> 00:26:32,990
+يعني صار في عندي كم كبير من الناس لو دخلهم
+
+365
+00:26:32,990 --> 00:26:36,130
+الفيروس نفس الفيروس مش هيعمل إنهم infection مش
+
+366
+00:26:36,130 --> 00:26:39,690
+هينقلوا لمين؟ للآخرين الـ herd أو الـ community
+
+367
+00:26:39,690 --> 00:26:46,390
+immunity وبالتالي لازم يكون سلالة جديدة هي اللي تعمل
+
+368
+00:26:46,390 --> 00:26:50,370
+الـ infection ممكن السلالات تبعت السنة هذه بعد عشر
+
+369
+00:26:50,370 --> 00:26:54,610
+سنين بعد عشر سنين لأن الآن الـ immunity weaned،
+
+370
+00:26:54,610 --> 00:26:58,410
+ضعفت الـ immunity ضده، فممكن يعمل كمرة circulation،
+
+371
+00:26:58,410 --> 00:27:02,030
+لكن مش ناقص هو أنه يرجع، لأنه عنده قدرة على أنه
+
+372
+00:27:02,030 --> 00:27:05,510
+يتغير بشكل مستمر، واحنا بنتكلم عن أكثر من one
+
+373
+00:27:05,510 --> 00:27:07,310
+hundred zero types
+
+375
+00:27:10,260 --> 00:27:14,640
+البرنامج للدخول للفيروس هو من خلال الـ Upper
+
+376
+00:27:14,640 --> 00:27:18,760
+Respiratory Tract  والتأثير محدود لهذه المنطقة،
+
+377
+00:27:18,760 --> 00:27:22,480
+يعني في المنطقة العليا من الـ Respiratory Tract،
+
+378
+00:27:22,480 --> 00:27:25,320
+فالرينوفيروس غالبًا يسبب تأثير الـ Lower
+
+379
+00:27:25,320 --> 00:27:29,880
+Respiratory Tract، وهذا ربما بسبب أنهم يطولون بشكل 
+
+380
+00:27:29,880 --> 00:27:35,560
+سيئ في 37 درجة، هذه أنا بتوقف عندها، لابد أن نفهم
+
+381
+00:27:35,560 --> 00:27:41,620
+أنه في فرق ما بين they prefer أيش أنا prefer؟ يفضل
+
+382
+00:27:41,620 --> 00:27:46,980
+زي فاكرين كلمة minimum maximum optimum الـ maximum
+
+383
+00:27:46,980 --> 00:27:51,220
+after which there is no growth الـ minimum below
+
+384
+00:27:51,220 --> 00:27:54,480
+which there is no growth الـ optimum هو الـ maximum
+
+385
+00:27:54,480 --> 00:27:59,520
+of growth هو الأفضل الأقل لو ميلنا على مش على ما
+
+386
+00:27:59,520 --> 00:28:02,460
+نقول تلاتة و ثلاثين هي الأفضل لو طلعنا عارفة و تلاتين
+
+387
+00:28:02,460 --> 00:28:06,100
+أقل خمسة و ثلاثين أقل ستة و ثلاثين أقل سبعة و ثلاثين
+
+388
+00:28:06,100 --> 00:28:08,480
+أقل ثمانية و ثلاثين أقل لكن مش مهمة الحاجة إن مافيش
+
+389
+00:28:08,480 --> 00:28:13,630
+growth في growth لكن بدرجة يقولنا منخفضة إذا هذا
+
+390
+00:28:13,630 --> 00:28:19,010
+هذا كله أنا بأقوله لك عشان ما تنفوش إمكانية إنه الـ
+
+391
+00:28:19,010 --> 00:28:22,630
+rhino virus ممكن يعمل Lower respiratory tract
+
+392
+00:28:22,630 --> 00:28:25,450
+هتقوله إنه ما هي سبعة و ثلاثين قلت لكم إن أنا
+
+393
+00:28:25,450 --> 00:28:29,630
+الآن إنه سبعة و ثلاثين صحيح مش مش الـ optimum
+
+394
+00:28:29,630 --> 00:28:33,090
+temperature لكن a temperature at which the virus
+
+395
+00:28:33,090 --> 00:28:36,370
+still can صحيح poorly grow بس إذا كان الـ immune
+
+396
+00:28:36,370 --> 00:28:41,170
+system تلفان خالص يبقى بيقدر ينمو في هذا المكان
+
+397
+00:28:41,170 --> 00:28:45,750
+يعمل الـ infection لكن هي الحالة كما قلنا مرة
+
+398
+00:28:45,750 --> 00:28:52,070
+عادية الـ immunity is zero-type specific and is a
+
+399
+00:28:52,070 --> 00:28:55,470
+function of nasal secretory IgA rather than
+
+400
+00:28:55,470 --> 00:29:00,930
+humoral antibody هو أصلا الفيروس اللي بده يروح وين
+
+401
+00:29:00,930 --> 00:29:04,750
+المكان المفضل تبعه؟ الـ Upper Respiratory في الـ
+
+402
+00:29:04,750 --> 00:29:09,630
+Nasal Cavity إذا اتكون IgA ملائم له، انتهى الموضوع
+
+403
+00:29:09,630 --> 00:29:15,310
+لكن المشكلة انتهى الموضوع لـ Single Serotype كل
+
+404
+00:29:15,310 --> 00:29:21,470
+مرة يعني تتخيل الأنف جدش بدي يحتوي على IgA لأنواع
+
+405
+00:29:21,470 --> 00:29:25,870
+مختلفة من الـ micro organisms من ضمنها اللي هو 100
+
+406
+00:29:25,870 --> 00:29:32,540
+Serotype لمين؟ لل .. ال .. ال .. الـ Rhinovirus إذا
+
+407
+00:29:32,540 --> 00:29:35,600
+أنا مش بتمنين لعلى Humoral Antibody ولا على Cell
+
+408
+00:29:35,600 --> 00:29:41,860
+Mediated Immunity بتمنين فقط على الـ IgA وهذه أنا
+
+409
+00:29:41,860 --> 00:29:45,200
+.. يعني ال .. ال .. نستغل الفرصة ونأكد على إن
+
+410
+00:29:45,200 --> 00:29:49,220
+موضوع الـ immunity في الـ viral diseases بتختلف
+
+411
+00:29:49,220 --> 00:29:52,840
+اختلاف جذري من فيروس إلى آخر قد تتشابه بعض
+
+412
+00:29:52,840 --> 00:29:57,870
+الفيروسات لكن في الآخر لستراتيجيات اللي بيحدث من
+
+413
+00:29:57,870 --> 00:30:01,410
+خلالها المرض أو من خلال المناعة لحقيقة مختلفة
+
+414
+00:30:01,410 --> 00:30:06,830
+تمامًا اذكركم بالـ Respiratory syncytial virus لما
+
+415
+00:30:06,830 --> 00:30:13,850
+قلنا لكم إن وجود immunoglobulin ضعف من الأعراض زاد
+
+416
+00:30:13,850 --> 00:30:18,030
+من حد المرض وخاصة لما أعطينا vaccine فاكرين لما
+
+417
+00:30:18,030 --> 00:30:20,210
+أعطينا vaccine قلنا لكم لما جربنا الـ killed
+
+418
+00:30:20,210 --> 00:30:24,170
+vaccine لجينا إن الـ killed vaccine ساقة حالة
+
+419
+00:30:24,170 --> 00:30:28,050
+المرضى أكثر من اللي ما عندهم مش vaccine والسبب إن
+
+420
+00:30:28,050 --> 00:30:32,030
+الـ binding للـ antibody مع الـ virus على الـ complex
+
+421
+00:30:32,030 --> 00:30:34,070
+على الـ activation للـ complement على الـ
+
+422
+00:30:34,070 --> 00:30:38,190
+destruction للـ lung cells جابت اللي هو الـ الـ
+
+423
+00:30:38,190 --> 00:30:41,250
+other immune cell وعملت اللي قلنا immunological
+
+424
+00:30:41,250 --> 00:30:47,260
+storm إذا ومرة شفنا في الـ في الـPolio إنه
+
+425
+00:30:47,260 --> 00:30:52,680
+النشاط الأساسي للـIgA والـIgG، في الكوكساكي فيروس
+
+426
+00:30:52,680 --> 00:30:57,860
+للـIgG، للـIgG، قلنا مظبوط، هي أنها نفقت لمين؟
+
+427
+00:30:57,860 --> 00:31:04,200
+للـIgA، إذن الـImmunology في الـVirology بدنا نطلع
+
+428
+00:31:04,200 --> 00:31:09,040
+عليه بشكل مختلف من فيروس إلى فيروس آخر الـ
+
+429
+00:31:09,040 --> 00:31:11,540
+incubation period is very short، من اثنين لأربعة
+
+430
+00:31:11,540 --> 00:31:15,960
+أيام، sneezing، nasal discharge، إفرازات من الأنف،
+
+431
+00:31:15,960 --> 00:31:18,700
+sore throat احتقان في الحلق، cough and headache
+
+432
+00:31:18,700 --> 00:31:23,100
+are common، لكن الحرارة الحقيقة، ارتفاع الحرارة،
+
+433
+00:31:23,100 --> 00:31:27,420
+إذا وجد، فبكون very mild، يعني جدش حالتنا سبعة و
+
+434
+00:31:27,420 --> 00:31:29,560
+ثلاثين، سبعة و ثلاثين و نصف ممكن تكون
+
+435
+00:31:33,150 --> 00:31:36,630
+الفلوقات الرئيسية بين الـ influenza و الرشح إن
+
+436
+00:31:36,630 --> 00:31:40,830
+الرشح مافيش فيه حرارة و الـ influenza في حرارة الـ
+
+437
+00:31:40,830 --> 00:31:44,790
+influenza في ألم في المفاصل والعضلات بينما الرشح
+
+438
+00:31:44,790 --> 00:31:49,110
+مافيش فيه ألم في المفاصل والعضلات لذلك المرشح
+
+439
+00:31:49,110 --> 00:31:53,330
+ما يعطوه عذر عن الانتحان بس الـinfluenza ممكن يعطوه
+
+440
+00:31:53,330 --> 00:31:58,710
+ولا يعطوه أيضًا لأن أنا ما يعطوه أيضًا خلاص لما
+
+441
+00:31:58,710 --> 00:32:01,010
+ترشحوش أنت ولا ترليزهم
+
+442
+00:32:03,820 --> 00:32:09,200
+إذن هذه الأعراض السريعة قلنا Sneezing العطس
+
+443
+00:32:09,200 --> 00:32:13,060
+المتكرر نزل ديشارج sore throat cough headache are
+
+444
+00:32:13,060 --> 00:32:16,480
+common symptoms a chilly sensation may occur يعني
+
+445
+00:32:16,480 --> 00:32:22,240
+شعور بالبرد إنك سجعني يعني but there are few other
+
+446
+00:32:22,240 --> 00:32:25,280
+systemic symptoms مش زي الـ influenza الـ influenza
+
+447
+00:32:25,280 --> 00:32:30,160
+في كثير systemic symptoms the illness last about
+
+448
+00:32:30,160 --> 00:32:39,250
+one week طبعًا شركاتكم و لأنكم من ثلاثة أيام لأسبوع
+
+449
+00:32:39,250 --> 00:32:44,370
+طبعًا الحد تبعته بتكون within 48 hours اللي هو يعني
+
+450
+00:32:44,370 --> 00:32:49,050
+الـ maximum peak تبعت الأعراض بتكون حوالي 48 ساعة و
+
+451
+00:32:49,050 --> 00:32:54,070
+بعد ذلك بيضل أثاره لكن it subsidized gradually و
+
+452
+00:32:54,070 --> 00:32:57,930
+في نهاية الأسبوع بالفعل بيكون تقريبًا اختفى لذلك
+
+453
+00:32:57,930 --> 00:33:02,840
+اللي بده يسجل إنه مريض بالـ .. لازم يعني ..روح على
+
+454
+00:33:02,840 --> 00:33:06,820
+طبيب في خلال فترة الأعراض نفسها أو على مدرس تبعه
+
+455
+00:33:06,820 --> 00:33:12,220
+عشان يعديه بالمرة هو الثاني Note that other
+
+456
+00:33:12,220 --> 00:33:16,500
+viruses such as coronavirus, adenovirus, influenza
+
+457
+00:33:16,500 --> 00:33:20,880
+C virus, kokusaki virus also causes the common
+
+458
+00:33:20,880 --> 00:33:24,020
+cold syndrome أما كم واحد صاروا؟ واحد، اثنين،
+
+459
+00:33:24,020 --> 00:33:27,680
+ثلاثة، أربعة بالإضافة إلى مين؟ إلى اللي هو الـ
+
+460
+00:33:27,680 --> 00:33:34,260
+virus تبعنا صاروا خمسة فيروسات الـ lab diagnosis ممكن
+
+461
+00:33:34,260 --> 00:33:39,560
+يعزل الـ virus في الـ cell culture لكن زي ما
+
+462
+00:33:39,560 --> 00:33:43,740
+حكيته عليكم نظرًا لإن المرض بسيط و غالبًا الناس
+
+463
+00:33:43,740 --> 00:33:47,540
+ما بتشهورش بحاجة إلى الذهاب إلى الطبيب وبالتالي
+
+464
+00:33:47,540 --> 00:33:52,480
+موضوع الـ diagnosis مش كثير مهتمد على الـ laboratory
+
+465
+00:33:52,480 --> 00:33:56,200
+test أكثر ما مهتمد على اللي هو الـ clinical picture
+
+466
+00:33:56,200 --> 00:33:59,870
+اللي عرض اللي هنا ده ذكرناه Surgical tests are
+
+467
+00:33:59,870 --> 00:34:03,590
+not done يعني ممكن نهزل الفيروس بس الكلش اللي كان
+
+468
+00:34:03,590 --> 00:34:07,150
+ما بنعملهاش ومافيش surgery مش طالع الـ surgery وبالتالي
+
+469
+00:34:07,150 --> 00:34:10,810
+جونا الـ diagnosis ده معتمد تمامًا على الـ clinical
+
+470
+00:34:10,810 --> 00:34:15,850
+picture treatment and prevention no no specific
+
+471
+00:34:15,850 --> 00:34:23,290
+antiviral therapy is available مافيش علاج كـ
+
+472
+00:34:23,290 --> 00:34:26,070
+antivirus يعني كـ antivirus هايش بعطوك اللي لما
+
+473
+00:34:26,070 --> 00:34:31,050
+تكون عشان مرحلمانتوا بقالي مضادات حيوية؟ كلكم
+
+474
+00:34:31,050 --> 00:34:34,130
+بتاخدوا مضادات حيوية بأساسها، مظبوط؟ بوصفة ..
+
+475
+00:34:34,130 --> 00:34:38,210
+بوصفة طبية ذاتية من خلال التطبيق الذاتي طبعًا بعد
+
+476
+00:34:38,210 --> 00:34:40,730
+الأسبوع العالم المضادات الحيوية ممنوعة ملعن بطن
+
+477
+00:34:40,730 --> 00:34:44,170
+اه؟ ممنوعة ملعن بطن ناخد مضادات حيوية بدون وصفة
+
+478
+00:34:44,170 --> 00:34:49,520
+طبية Vaccines appear impractical because of the
+
+479
+00:34:49,520 --> 00:34:53,360
+large number of serotypes إلا إذا يوم من الأيام
+
+480
+00:34:53,360 --> 00:34:58,920
+أحد العلماء اكتشف له common antigen to all of these
+
+481
+00:34:58,920 --> 00:35:03,900
+virus إذا لجينا common antigen protective هذا
+
+482
+00:35:03,900 --> 00:35:09,000
+بيكون حل للرشح في العالم وأعتقد أنه هيكون إنجاز
+
+483
+00:35:09,000 --> 00:35:10,840
+كبير إذا بنلجب الفعل مثل هذا
+
+484
+00:35:15,250 --> 00:35:20,690
+الأنفلوانزا في هذا العام نزل خبر إن احتمال يصير
+
+485
+00:35:20,690 --> 00:35:27,430
+عندنا vaccine عام لأن في claim بتقول إن علماء
+
+486
+00:35:27,430 --> 00:35:31,110
+ويردوا common antigen للأنفلوانزا و it is
+
+487
+00:35:31,110 --> 00:35:34,110
+protective يعني protective بمعنى إنه لما يتكونوا
+
+488
+00:35:34,110 --> 00:35:37,680
+antibody الـ Antibody بيعمل الـ Neutralization
+
+489
+00:35:37,680 --> 00:35:40,960
+للفيروس من خلال هذا الـ Antigen اللي هو common لكل
+
+490
+00:35:40,960 --> 00:35:44,780
+السلالات تبع الـ Influenza هذا بيكون برضه يعني
+
+491
+00:35:44,780 --> 00:35:49,460
+breakthrough اختراق طبي مهم جدًا في القرن الواحد
+
+492
+00:35:49,460 --> 00:35:54,720
+والعشرين Paper
+
+493
+00:35:54,720 --> 00:35:57,420
+tissue impregnated with a .. هتطلعب على هذا الآن
+
+494
+00:35:57,420 --> 00:36:02,180
+هذه يمكن بتعرفوهاش شخصية أنتم تتعلموها Paper
+
+495
+00:36:02,180 --> 00:36:04,360
+tissue Paper tissue اللي هو الـ clinics يعني اه
+
+496
+00:36:05,270 --> 00:36:08,170
+impregnated with a combination of citric acid،
+
+497
+00:36:08,170 --> 00:36:12,270
+بتعرفوا citric acid؟ إيش هو؟ حمض الليمون، حمض
+
+498
+00:36:12,270 --> 00:36:16,430
+الليمون، which inactivates rhinoviruses مش قلت لكم
+
+499
+00:36:16,430 --> 00:36:20,690
+أنا إنه في هدى أصلا عند الناس إنهم بي .. بي نقطوا
+
+500
+00:36:20,690 --> 00:36:25,850
+عصير ليمون أو قطرة من عصير الليمون في الأنف عشان 
+
+501
+00:36:25,850 --> 00:36:30,210
+.. عشان يقتله اللي هو ال virus، فيبدو إنه أيه كمان
+
+502
+00:36:30,210 --> 00:36:36,780
+طريقة بلدية يعني، بس أوروبية وهو ينكتفع الرينوفيروس
+
+503
+00:36:36,780 --> 00:36:40,260
+ويقل الترانزميشن لسوديوم اللوريات السلفات عند
+
+504
+00:36:40,260 --> 00:36:44,520
+استخدامه لإزالة الفيروس من أعضاء الجهاز التنفسي
+
+505
+00:36:44,520 --> 00:36:47,880
+الجهاز التنفسي يعني لو كان الواحد من عشان يمنع
+
+506
+00:36:47,880 --> 00:36:54,360
+الانتقال للآخرين ممكن بالفعل يستخدم ورق فيه اللي
+
+507
+00:36:54,360 --> 00:36:58,360
+هو إنّه سيتريك أسد زي دلوقت ال SD لسوديوم اللوريات
+
+508
+00:36:58,360 --> 00:37:03,160
+السلفات High doses of vitamin C طبعا تعرفوا إن
+
+509
+00:37:03,160 --> 00:37:07,580
+الوصفة اشرب vitamin C أو خد عصائر لأن فيها vitamin
+
+510
+00:37:07,580 --> 00:37:14,460
+C والحقيقة إنه يعني لا يوجد دليل حقيقي على إن
+
+511
+00:37:14,460 --> 00:37:20,280
+vitamin C له علاقة بمحاربة الفيروس لكن درجة العادة
+
+512
+00:37:20,280 --> 00:37:25,500
+وزي بعض الأشياء اللي خدنا نقول المعتقدات الخاطئة
+
+513
+00:37:25,500 --> 00:37:29,830
+في الطب قد يكون هذا أحدها High doses of vitamin C
+
+514
+00:37:29,830 --> 00:37:32,330
+have little ability to prevent rhinovirus-induced
+
+515
+00:37:32,330 --> 00:37:37,590
+cold. اللوزينجس معناها الأقراص اللي من مصها مص زي
+
+516
+00:37:37,590 --> 00:37:45,150
+الـ strip cells اللي بتقول الحلقة الأقراص هذه لأنها
+
+517
+00:37:45,150 --> 00:37:48,890
+مش كبسولات ومش .. هذي بسموها أقراص مص اللي هي
+
+518
+00:37:48,890 --> 00:37:53,150
+لوزينجس Containing zinc gluconate are available
+
+519
+00:37:53,150 --> 00:37:57,310
+for the treatment of the common cold but their
+
+520
+00:37:57,310 --> 00:38:02,130
+efficacy remains unproved برضه وهي متاحة كنوع من
+
+521
+00:38:02,130 --> 00:38:06,390
+الـ remedy الشعبي اللي مقبول طبيا تمام زي كتير من
+
+522
+00:38:06,390 --> 00:38:10,030
+الأعشاب اللي بيحطوها بصدليات مقبولة طبيا لكن لسنا
+
+523
+00:38:10,030 --> 00:38:14,090
+متأكدين لا نستطيع أن نوصل بيها من ناحية علمية
+
+524
+00:38:17,130 --> 00:38:22,010
+الفيروس الجميل اسمه Calicivirus Caliciviruses are
+
+525
+00:38:22,010 --> 00:38:25,910
+small single-stranded RNA of positive polarity
+
+526
+00:38:25,910 --> 00:38:28,750
+وطبعا كلمة positive polarity بتعطيكوا أي حق بإنه
+
+527
+00:38:28,750 --> 00:38:32,630
+ما يحتاجش إلى RNA polymerase و بتاعة الجينات اللي
+
+528
+00:38:32,630 --> 00:38:37,510
+ما أعرفش بالضبط بيكون infectious الذين يشاركون هذه
+
+529
+00:38:37,510 --> 00:38:42,150
+المميزات من عائلة بيكورنا فيروس كاليسي فيروس هم
+
+530
+00:38:42,150 --> 00:38:48,290
+مختلفين عن بيكورنا فيروس بحيث لديهم جينوم أكبر من
+
+531
+00:38:48,290 --> 00:38:51,510
+بيكورنا فيروس كاليسي فيروس كاليسي فيروس كاليسي
+
+532
+00:38:51,510 --> 00:38:54,430
+فيروس كاليسي فيروس كاليسي فيروس كاليسي فيروس
+
+533
+00:38:54,430 --> 00:38:55,530
+كاليسي فيروس كاليسي فيروس كاليسي فيروس كاليسي
+
+534
+00:38:55,530 --> 00:38:57,690
+كاليسي فيروس كاليسي فيروس كاليسي فيروس كاليسي
+
+535
+00:38:57,690 --> 00:39:03,850
+فيروس كاليسي فيروس كاليسي فيروس كالمن الفيروسات
+
+536
+00:39:03,850 --> 00:39:09,730
+اللي تابع هذا الهيباتيتس
+
+537
+00:39:09,730 --> 00:39:18,090
+E الهيباتيتس A انترك الهيباتيتس E كاليسي فيروس
+
+538
+00:39:21,470 --> 00:39:26,150
+DNA virus يبقى كل بالفعل Hepatitis virus مختلفين
+
+539
+00:39:26,150 --> 00:39:32,190
+الـ الـ ال Hepatitis C Flavivirus يعني يعني مختلفين
+
+540
+00:39:32,190 --> 00:39:36,470
+تماما في التصنيف لكن يشتركوا في قضية واحدة قلنا
+
+541
+00:39:36,470 --> 00:39:40,630
+وهي اللي هي إنّه الـ target بتبعهم هو اللي هو إذا
+
+542
+00:39:40,630 --> 00:39:44,670
+Norwalk و Hepatitis E virus هم تابعين لمجموعة
+
+543
+00:39:44,670 --> 00:39:46,350
+اسمها Calicivirus
+
+544
+00:39:48,480 --> 00:39:51,500
+نبدأ بالنوركولكفيروس المحارب اللي جاي إن شاء الله أعطيك
+
+545
+00:39:51,500 --> 00:39:51,720
+منها
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/fH1r8SPi7gw_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/fH1r8SPi7gw_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..ad9887771b03041e128a9b290a9d45c4c5994616
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/fH1r8SPi7gw_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 4806, "start": 21.24, "end": 48.06, "text": "بسم الله الرحمن الرحيم نبدأ ان شاء الله محاضرتنا اليوم و هي استكمال ال RNA انفلوفت فيروس و كنا قد بدأنا بالحديث عن الكوكساكي فيروس احد اهم مسببات ال meningitis او ال viral meningitis او ما يعرف بال aseptic meningitis هو و ال eco virus بالاضافة الى ال mumps virus كنا قديما و الان اقل من دي قبل بسبب وجود اللي هو ال vaccine", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 8717, 44510, 10721, 16472, 13412, 16606, 21984, 3714, 5016, 46958, 43500, 8315, 45595, 20498, 4032, 39896, 44713, 24793, 6027, 2423, 22484, 16472, 5172, 1211, 38688, 2655, 8978, 32887, 3794, 4032, 9122, 8315, 12174, 3215, 47525, 10721, 8315, 20666, 5016, 16254, 12984, 18871, 33251, 2407, 4117, 3794, 995, 4117, 1829, 8978, 32887, 3794, 1975, 24401, 1975, 16095, 3714, 35457, 3555, 9307, 2423, 46890, 16074, 1975, 2407, 2423, 16132, 46890, 16074, 1975, 2407, 19446, 37495, 28480, 20666, 382, 5250, 299, 46890, 16074, 31439, 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0.7794596354166666}, {"start": 2331.51, "end": 2332.43, "word": " كاليسي", "probability": 0.9697265625}, {"start": 2332.43, "end": 2332.43, "word": " فيروس", "probability": 0.8020833333333334}, {"start": 2332.43, "end": 2332.77, "word": " كاليسي", "probability": 0.98505859375}, {"start": 2332.77, "end": 2333.73, "word": " فيروس", "probability": 0.8380533854166666}, {"start": 2333.73, "end": 2334.03, "word": " كاليسي", "probability": 0.99033203125}, {"start": 2334.03, "end": 2334.43, "word": " فيروس", "probability": 0.8670247395833334}, {"start": 2334.43, "end": 2334.85, "word": " كاليسي", "probability": 0.99296875}, {"start": 2334.85, "end": 2335.17, "word": " فيروس", "probability": 0.89111328125}, {"start": 2335.17, "end": 2335.53, "word": " كاليسي", "probability": 0.99423828125}, {"start": 2335.53, "end": 2335.53, "word": " فيروس", "probability": 0.9124348958333334}, {"start": 2335.53, "end": 2335.53, "word": " كاليسي", "probability": 0.99501953125}, {"start": 2335.53, "end": 2335.53, "word": " فيروس", "probability": 0.9295247395833334}, {"start": 2335.53, "end": 2335.53, "word": " كاليسي", "probability": 0.9953125}, {"start": 2335.53, "end": 2335.53, "word": " فيروس", "probability": 0.9407552083333334}, {"start": 2335.53, "end": 2335.53, "word": " كاليسي", "probability": 0.995703125}, {"start": 2335.53, "end": 2335.53, "word": " فيروس", "probability": 0.9480794270833334}, {"start": 2335.53, "end": 2335.53, "word": " كاليسي", "probability": 0.99599609375}, {"start": 2335.53, "end": 2335.53, "word": " فيروس", "probability": 0.9547526041666666}, {"start": 2335.53, "end": 2335.53, "word": " كاليسي", "probability": 0.99609375}, {"start": 2335.53, "end": 2335.53, "word": " فيروس", "probability": 0.9611002604166666}, {"start": 2335.53, "end": 2335.53, "word": " كاليسي", "probability": 0.99609375}, {"start": 2335.53, "end": 2335.53, "word": " فيروس", "probability": 0.966796875}, {"start": 2335.53, "end": 2335.61, "word": " كاليسي", "probability": 0.99619140625}, {"start": 2335.61, "end": 2335.63, "word": " فيروس", "probability": 0.9684244791666666}, {"start": 2335.63, "end": 2336.03, "word": " كاليسي", "probability": 0.99619140625}, {"start": 2336.03, "end": 2336.77, "word": " فيروس", "probability": 0.9716796875}, {"start": 2336.77, "end": 2337.69, "word": " كاليسي", "probability": 0.99638671875}, {"start": 2337.69, "end": 2337.97, "word": " فيروس", "probability": 0.9720052083333334}, {"start": 2337.97, "end": 2339.15, "word": " كاليسي", "probability": 0.996484375}, {"start": 2339.15, "end": 2340.13, "word": " فيروس", "probability": 0.9734700520833334}, {"start": 2340.13, "end": 2341.09, "word": " كاليسي", "probability": 0.99638671875}, {"start": 2341.09, "end": 2341.75, "word": " فيروس", "probability": 0.9747721354166666}, {"start": 2341.75, "end": 2341.75, "word": " كال", "probability": 0.992431640625}], "temperature": 1.0}, {"id": 97, "seek": 235809, "start": 2342.69, "end": 2358.09, "text": "من الفيروسات اللي تابع هذا الهيباطيتس E الهيباطيتس A انترك الهيباطيتس E كليسي فيروس", "tokens": [27842, 27188, 13546, 41779, 9307, 13672, 1829, 6055, 16758, 3615, 23758, 2423, 3224, 1829, 3555, 41193, 36081, 3794, 462, 2423, 3224, 1829, 3555, 41193, 36081, 3794, 316, 16472, 2655, 31747, 2423, 3224, 1829, 3555, 41193, 36081, 3794, 462, 9122, 20292, 3794, 1829, 8978, 32887, 3794], "avg_logprob": -0.37805706910465076, "compression_ratio": 1.6483516483516483, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2342.69, "end": 2342.95, "word": "من", "probability": 0.64501953125}, {"start": 2342.95, "end": 2343.85, "word": " الفيروسات", "probability": 0.92626953125}, {"start": 2343.85, "end": 2345.17, "word": " اللي", "probability": 0.639404296875}, {"start": 2345.17, "end": 2345.55, "word": " تابع", "probability": 0.8932291666666666}, {"start": 2345.55, "end": 2345.75, "word": " هذا", "probability": 0.57275390625}, {"start": 2345.75, "end": 2349.73, "word": " الهيباطيتس", "probability": 0.7082432338169643}, {"start": 2349.73, "end": 2350.15, "word": " E", "probability": 0.343017578125}, {"start": 2350.15, "end": 2351.79, "word": " الهيباطيتس", "probability": 0.7809709821428571}, {"start": 2351.79, "end": 2352.09, "word": " A", "probability": 0.58251953125}, {"start": 2352.09, "end": 2353.01, "word": " انترك", "probability": 0.5272623697916666}, {"start": 2353.01, "end": 2354.29, "word": " الهيباطيتس", "probability": 0.8816615513392857}, {"start": 2354.29, "end": 2354.83, "word": " E", "probability": 0.80322265625}, {"start": 2354.83, "end": 2356.19, "word": " كليسي", "probability": 0.7664794921875}, {"start": 2356.19, "end": 2358.09, "word": " فيروس", "probability": 0.86572265625}], "temperature": 1.0}, {"id": 98, "seek": 238635, "start": 2361.47, "end": 2386.35, "text": "DNA virus يبقى كل بالفعل Hepatitis virus مختلفين ال ال ال Hepatitis C Flavivirus يعني يعني مختلفين تماما في التصنيف لكن يشتركوا في قضية واحدة قلنا وهي اللي هي انه ال target بتبعهم هو اللي هو إذا Norwalk و Hepatitis E virus هم تابعين لمجموعة اسمها Calicivirus", "tokens": [35, 5321, 5752, 7251, 3555, 4587, 7578, 28242, 20666, 5172, 30241, 30578, 267, 16074, 5752, 3714, 46456, 46538, 9957, 2423, 2423, 2423, 30578, 267, 16074, 383, 3235, 706, 592, 9619, 37495, 22653, 37495, 22653, 3714, 46456, 46538, 9957, 46811, 10943, 995, 8978, 16712, 9381, 22653, 5172, 44381, 7251, 8592, 2655, 31747, 14407, 8978, 12174, 11242, 10632, 36764, 24401, 3660, 12174, 1211, 8315, 37037, 1829, 13672, 1829, 39896, 16472, 3224, 2423, 3779, 39894, 3555, 3615, 16095, 31439, 13672, 1829, 31439, 11933, 15730, 6966, 12490, 4032, 30578, 267, 16074, 462, 5752, 8032, 2304, 6055, 16758, 3615, 9957, 32767, 7435, 2304, 45367, 3660, 24525, 2304, 11296, 3511, 299, 592, 9619], "avg_logprob": -0.21252894249779206, "compression_ratio": 1.7443946188340806, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2361.47, "end": 2362.27, "word": "DNA", "probability": 0.7041015625}, {"start": 2362.27, "end": 2362.99, "word": " virus", "probability": 0.46142578125}, {"start": 2362.99, "end": 2363.31, "word": " يبقى", "probability": 0.80908203125}, {"start": 2363.31, "end": 2363.65, "word": " كل", "probability": 0.642578125}, {"start": 2363.65, "end": 2364.37, "word": " بالفعل", "probability": 0.8497721354166666}, {"start": 2364.37, "end": 2364.91, "word": " Hepatitis", "probability": 0.7909342447916666}, {"start": 2364.91, "end": 2365.21, "word": " virus", "probability": 0.6787109375}, {"start": 2365.21, "end": 2366.15, "word": " مختلفين", "probability": 0.98291015625}, {"start": 2366.15, "end": 2366.93, "word": " ال", "probability": 0.8623046875}, {"start": 2366.93, "end": 2367.27, "word": " ال", "probability": 0.345947265625}, {"start": 2367.27, "end": 2368.19, "word": " ال", "probability": 0.72119140625}, {"start": 2368.19, "end": 2368.59, "word": " Hepatitis", "probability": 0.8935546875}, {"start": 2368.59, "end": 2368.83, "word": " C", "probability": 0.5849609375}, {"start": 2368.83, "end": 2370.35, "word": " Flavivirus", "probability": 0.7314453125}, {"start": 2370.35, "end": 2371.23, "word": " يعني", "probability": 0.760498046875}, {"start": 2371.23, "end": 2371.57, "word": " يعني", "probability": 0.78564453125}, {"start": 2371.57, "end": 2372.19, "word": " مختلفين", "probability": 0.9910888671875}, {"start": 2372.19, "end": 2372.77, "word": " تماما", "probability": 0.9807942708333334}, {"start": 2372.77, "end": 2373.25, "word": " في", "probability": 0.94140625}, {"start": 2373.25, "end": 2373.81, "word": " التصنيف", "probability": 0.9805908203125}, {"start": 2373.81, "end": 2374.11, "word": " لكن", "probability": 0.88427734375}, {"start": 2374.11, "end": 2374.71, "word": " يشتركوا", "probability": 0.97744140625}, {"start": 2374.71, "end": 2374.97, "word": " في", "probability": 0.96728515625}, {"start": 2374.97, "end": 2375.73, "word": " قضية", "probability": 0.982421875}, {"start": 2375.73, "end": 2376.19, "word": " واحدة", "probability": 0.9759114583333334}, {"start": 2376.19, "end": 2376.47, "word": " قلنا", "probability": 0.6543782552083334}, {"start": 2376.47, "end": 2377.45, "word": " وهي", "probability": 0.853515625}, {"start": 2377.45, "end": 2378.29, "word": " اللي", "probability": 0.851318359375}, {"start": 2378.29, "end": 2378.51, "word": " هي", "probability": 0.9501953125}, {"start": 2378.51, "end": 2378.87, "word": " انه", "probability": 0.545166015625}, {"start": 2378.87, "end": 2379.05, "word": " ال", "probability": 0.888671875}, {"start": 2379.05, "end": 2379.27, "word": " target", "probability": 0.97412109375}, {"start": 2379.27, "end": 2379.63, "word": " بتبعهم", "probability": 0.699462890625}, {"start": 2379.63, "end": 2379.91, "word": " هو", "probability": 0.98046875}, {"start": 2379.91, "end": 2380.25, "word": " اللي", "probability": 0.8955078125}, {"start": 2380.25, "end": 2380.37, "word": " هو", "probability": 0.81787109375}, {"start": 2380.37, "end": 2380.63, "word": " إذا", "probability": 0.4722900390625}, {"start": 2380.63, "end": 2381.33, "word": " Norwalk", "probability": 0.6060791015625}, {"start": 2381.33, "end": 2381.87, "word": " و", "probability": 0.70361328125}, {"start": 2381.87, "end": 2382.69, "word": " Hepatitis", "probability": 0.8771158854166666}, {"start": 2382.69, "end": 2382.97, "word": " E", "probability": 0.919921875}, {"start": 2382.97, "end": 2383.41, "word": " virus", "probability": 0.787109375}, {"start": 2383.41, "end": 2383.85, "word": " هم", "probability": 0.978271484375}, {"start": 2383.85, "end": 2384.19, "word": " تابعين", "probability": 0.9068603515625}, {"start": 2384.19, "end": 2384.67, "word": " لمجموعة", "probability": 0.82939453125}, {"start": 2384.67, "end": 2385.07, "word": " اسمها", "probability": 0.94482421875}, {"start": 2385.07, "end": 2386.35, "word": " Calicivirus", "probability": 0.8260498046875}], "temperature": 1.0}, {"id": 99, "seek": 239171, "start": 2388.48, "end": 2391.72, "text": "نبدأ بالنوركولكفيروس المحارب اللي جاي ان شاء اعطيك منها", "tokens": [1863, 44510, 10721, 20666, 1863, 13063, 4117, 12610, 4117, 5172, 13546, 41779, 9673, 5016, 9640, 3555, 13672, 1829, 10874, 47302, 16472, 13412, 16606, 1975, 3615, 9566, 1829, 4117, 9154, 11296], "avg_logprob": -0.5206653379624889, "compression_ratio": 1.2, "no_speech_prob": 0.0, "words": [{"start": 2388.4800000000005, "end": 2389.1200000000003, "word": "نبدأ", "probability": 0.8326822916666666}, {"start": 2389.1200000000003, "end": 2389.76, "word": " بالنوركولكفيروس", "probability": 0.5773518880208334}, {"start": 2389.76, "end": 2390.44, "word": " المحارب", "probability": 0.4810791015625}, {"start": 2390.44, "end": 2390.5, "word": " اللي", "probability": 0.659423828125}, {"start": 2390.5, "end": 2390.66, "word": " جاي", "probability": 0.74951171875}, {"start": 2390.66, "end": 2390.74, "word": " ان", "probability": 0.7900390625}, {"start": 2390.74, "end": 2391.06, "word": " شاء", "probability": 0.9873046875}, {"start": 2391.06, "end": 2391.5, "word": " اعطيك", "probability": 0.62734375}, {"start": 2391.5, "end": 2391.72, "word": " منها", "probability": 0.58251953125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2391.7714375, "duration_after_vad": 2295.7337499999912}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..599c090aca1fb917063636853d0acdf894d3d462
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU.srt
@@ -0,0 +1,1851 @@
+1
+00:00:20,940 --> 00:00:23,780
+بسم الله الرحمن الرحيم نكمل اليوم إن شاء الله آخر 
+
+2
+00:00:23,780 --> 00:00:29,180
+فيروس في المحاضرة وهذا الفيروس يعتبر من عائلة ال
+
+3
+00:00:29,180 --> 00:00:35,260
+retro viruses وهو الأخ الشقيق للـ HIV لكن هناك بعض
+
+4
+00:00:35,260 --> 00:00:37,860
+التشابهات وبعض الاختلافات سنتطرق إن شاء الله في
+
+5
+00:00:37,860 --> 00:00:41,260
+هذه المحاضرة وسنرى الأمراض التي يسببها وكيفية
+
+6
+00:00:41,260 --> 00:00:48,550
+إحداثه للسلطان في البشر والطرق المستخدمة من خلال
+
+7
+00:00:48,550 --> 00:00:51,810
+هذا البرنامج تختلف عن الـ onco viruses المعروفين التي
+
+8
+00:00:51,810 --> 00:00:55,610
+هم سبب السرطان الصورة التي معنا بتوضح أن في
+
+9
+00:00:55,610 --> 00:01:00,530
+اند two copies of the same genome وهذا ينطبق على
+
+10
+00:01:00,530 --> 00:01:04,190
+ما قلنا سابقا بأن الـ retrovirus يحتوي على كلمة
+
+11
+00:01:04,190 --> 00:01:07,650
+diploid كلمة diploid يعني two copies of the same
+
+12
+00:01:07,650 --> 00:01:12,250
+gene  مش قطعتين مختلفتين زي قطعة مختلفة زي الـ
+
+13
+00:01:12,250 --> 00:01:16,110
+influenza أو زي الـ rheovirus  ليست retrovirus
+
+14
+00:01:16,110 --> 00:01:21,210
+لأ هم قطعتين نسختين من معنى آخر إنهم يشبهوا بعض
+
+15
+00:01:26,120 --> 00:01:28,940
+هناك في الـ retroviruses only two medically
+
+16
+00:01:28,940 --> 00:01:32,060
+important viruses التي هم الـ human T cell
+
+17
+00:01:32,060 --> 00:01:34,620
+lymphotropic virus التي نحن قيد دراسته اليوم
+
+18
+00:01:34,620 --> 00:01:38,740
+والثاني هو الـ human immunodeficiency virus أو الـ
+
+19
+00:01:38,740 --> 00:01:43,000
+HIV الأمراض التي بسببها هذا الفيروس التي نحن بصدد
+
+20
+00:01:43,000 --> 00:01:46,420
+دراسته اليوم هم مرضين واحد هو عبارة عن cancer
+
+21
+00:01:46,420 --> 00:01:50,500
+ويسمى adult T cell leukemia أو adult T cell
+
+22
+00:01:50,500 --> 00:01:55,100
+lymphoma لأنه يصيب الـ lymphocytes وتحديدًا الـ
+
+23
+00:01:55,100 --> 00:02:00,480
+CD4 Plus Lymphocyte أذكركم بمين برضه؟ بالـ HIV،
+
+24
+00:02:00,480 --> 00:02:04,300
+الـ HIV برضه يصيب هذا النوع منها من الخلايا إن
+
+25
+00:02:04,300 --> 00:02:07,140
+المرض الثاني عبارة عن neurological disease
+
+26
+00:02:07,140 --> 00:02:11,240
+neurological disease يعني مرض له علاقة بالأعصاب أو
+
+27
+00:02:11,240 --> 00:02:16,760
+يسموه myelopathy أو HTLV associated myelopathy و
+
+28
+00:02:16,760 --> 00:02:22,040
+يُختصر HAN H A N كمان مرة HTLV associated
+
+29
+00:02:22,040 --> 00:02:25,940
+myelopathy  أيه الأسماء الثانية مش كثير معنيين فيها
+
+30
+00:02:25,940 --> 00:02:31,400
+هناك نسخة أخرى من الفيروس يسموها HTLV-2 ويعتقد
+
+31
+00:02:31,400 --> 00:02:37,100
+أنها تسبب نفس الأمراض لكن العلاقة بين الفيروس الذي
+
+32
+00:02:37,100 --> 00:02:42,100
+هو نسخة نين HTLV2 وما بين المرضين اللذين ذكرناهم قبل
+
+33
+00:02:42,100 --> 00:02:46,520
+قليل الـ association مش بنفس قوة الـ association ما
+
+34
+00:02:46,520 --> 00:02:51,860
+بين HTLV1 و هذين المرضين بمعنى آخر ماعندناش دلائل
+
+35
+00:02:51,860 --> 00:02:58,260
+بحجم الدلائل التي تُتهم أو تُورط الأول في هذين
+
+36
+00:02:58,260 --> 00:02:58,760
+المرضين
+
+37
+00:03:01,490 --> 00:03:09,190
+الـHTLV والـHIV هما فيروسين مهمين في مصادر التجارة
+
+38
+00:03:09,190 --> 00:03:14,950
+كلاهما enveloped واضح أننا نتكلم عن RNA enveloped
+
+39
+00:03:14,950 --> 00:03:20,070
+فيروسات مع ترانسكريبتيز يعني لديهم الإنزيم اسمه
+
+40
+00:03:20,070 --> 00:03:22,170
+reverse transcriptase على الرغم من أنهم خدوا
+
+41
+00:03:22,170 --> 00:03:27,270
+بالـ positive polarity RNA إذا لماذا يلزم في
+
+42
+00:03:27,270 --> 00:03:32,040
+هذه الحالة reverse transcriptase؟ طب ليش يلزم
+
+43
+00:03:32,040 --> 00:03:36,060
+يتحول إلى DNA؟
+
+44
+00:03:36,060 --> 00:03:40,400
+جزء من الـ cycle تبعت و ليش؟ بيعمل integration لأن
+
+45
+00:03:40,400 --> 00:03:42,560
+أنا ساتر أن أنا أعمل integration بـ RNA لازم أعمل
+
+46
+00:03:42,560 --> 00:03:46,200
+integration بمين؟ بـ DNA إذا يلزموا في هذه الحالة
+
+47
+00:03:46,200 --> 00:03:49,360
+الذي هو من عنده reverse transcriptase كلاهما
+
+48
+00:03:49,360 --> 00:03:54,220
+يحتوي على reverse transcriptase both have
+
+49
+00:03:54,220 --> 00:03:57,520
+deployed كنا deployed يعني two copies of the same
+
+50
+00:03:57,520 --> 00:04:06,830
+genome الآن نجي للفرقات الفرق الأول HIV kills T
+
+51
+00:04:06,830 --> 00:04:13,690
+cells بينما الـ HTLV immortalize ايش معناه موت ايش
+
+52
+00:04:13,690 --> 00:04:18,730
+عكسها خلود مظبوط الموت عكسه خلود الـ HIV بيموت
+
+53
+00:04:18,730 --> 00:04:23,020
+الخلية بينما هذا الفيروس بيعملها transformation إلى
+
+54
+00:04:23,020 --> 00:04:25,740
+cancer cell وأنت تعرف أن الـ cancer cell is
+
+55
+00:04:25,740 --> 00:04:29,460
+immortal cell وبالتالي فيه فرق بين التانين لكن
+
+56
+00:04:29,460 --> 00:04:33,660
+خدوا بالكم سواء كانت ماتت أو immortal الـ function
+
+57
+00:04:33,660 --> 00:04:36,920
+تبعها موجودة مش موجودة الـ function وبالتالي
+
+58
+00:04:36,920 --> 00:04:42,080
+التانين هيولدوا sort of lower immunity يعني مش هم
+
+59
+00:04:42,080 --> 00:04:46,080
+بنقول immunodeficiency syndrome الـ HIV وايضا كمان
+
+60
+00:04:46,080 --> 00:04:49,700
+هذا يؤدي إلى نوع من انخفاض في جهاز المناعة
+
+61
+00:04:56,270 --> 00:05:00,130
+في فرصة أخرى نتعرف على الـ HIV من خلال هذا
+
+62
+00:05:00,130 --> 00:05:03,470
+الفيروس لأنه يتكلم على نفس الـ structure تقريبًا بين
+
+63
+00:05:03,470 --> 00:05:07,740
+الاثنين فمثلًا كل الـ retroviruses يحتوي على three
+
+64
+00:05:07,740 --> 00:05:11,520
+structural genes مشهورين جدًا اسمهم gag و pol و env
+
+65
+00:05:11,520 --> 00:05:16,960
+فأضفنا اسمهم structural genes our virus contains
+
+66
+00:05:16,960 --> 00:05:21,340
+two functional genes أو regulatory genes اسمهم TAX
+
+67
+00:05:21,340 --> 00:05:26,760
+and REX لحظة الـ TAX and REX هتلاقي أنه يلهم شبه
+
+68
+00:05:26,760 --> 00:05:31,660
+كبير بينهم وبين التي هم الـ functional أو الـ
+
+69
+00:05:31,660 --> 00:05:36,700
+regulatory genes تبعون الـ HIV كلمة شبه في الـ size
+
+70
+00:05:36,700 --> 00:05:40,600
+وفي الـ structure وفي الـ function طب أيه ده يشبهوا
+
+71
+00:05:40,600 --> 00:05:44,140
+بعض في الـ structure ويشبهوا بعض في الـ size وفي الـ
+
+72
+00:05:44,140 --> 00:05:48,040
+function؟ ليش يختلفوا عن بعض؟ ليش يختلفوا عن
+
+73
+00:05:48,040 --> 00:05:51,600
+بعض؟ لو هم كلمة يشبهوا مش identical يعني لو
+
+74
+00:05:51,600 --> 00:05:55,680
+identical كانوا نفس الاسم بس مش identical زي مثلًا
+
+75
+00:05:55,680 --> 00:05:59,020
+الـ gag و الـ pol و الـ env identical فأطلهم نفس الـ
+
+76
+00:05:59,020 --> 00:06:03,620
+أيه؟ نفس الاسم لكن هذول اختلفوا بيدكركوا بس بنقطة
+
+77
+00:06:03,620 --> 00:06:12,100
+مهمة جدًا إنه قد نتشابه في الـ size قد نتشابه في الـ
+
+78
+00:06:12,100 --> 00:06:16,440
+function زي ما احنا الآن هنا طلاب هاي وظيفتنا طلاب
+
+79
+00:06:16,440 --> 00:06:21,120
+كنا نمتلك عقل العقل له وظيفته يفكر ويدرس ويديب
+
+80
+00:06:21,120 --> 00:06:25,440
+على بقى في الامتحان تمام؟ هل الأداء الذي موجود في
+
+81
+00:06:25,440 --> 00:06:30,180
+الفصل للجميع الجميع يشترك بيد الخاصية لكن هل
+
+82
+00:06:30,180 --> 00:06:35,350
+الأداء تبع الوظيفة بنفس الكفاءة؟ أذكركم بمثال حقيقي
+
+83
+00:06:35,350 --> 00:06:41,550
+درسناه لما درسنا الـ papilloma virus كنا في الـ
+
+84
+00:06:41,550 --> 00:06:44,710
+papilloma virus يا بنات في بعض السلالات بعض
+
+85
+00:06:44,710 --> 00:06:48,830
+السلالات تعمل cancer cervical cancer وبعض السلالات
+
+86
+00:06:48,830 --> 00:06:52,290
+ما تعملش لما جينا تطلعنا على الجينات المسؤولة رجاله
+
+87
+00:06:52,290 --> 00:06:57,790
+مائية 16 و18 E6 وE7 الموجودين في كل الـ
+
+88
+00:06:57,790 --> 00:07:02,130
+Papilloma Viruses ايش معنى 16 و18 هم اللذين عملوا
+
+89
+00:07:02,130 --> 00:07:05,630
+cancer والباقيين الذين عملوش cancer مع أنه كلهم
+
+90
+00:07:05,630 --> 00:07:10,230
+يحتوي على E6 وE7 فسرناكم في حينها قلنا لكم أن
+
+91
+00:07:10,230 --> 00:07:13,470
+البروتينات التي خارجة من الـ E6 وE7 من هذين
+
+92
+00:07:13,470 --> 00:07:17,290
+السلالاتين أكثر قدرة على الارتباط بالـ
+
+93
+00:07:17,290 --> 00:07:21,030
+Retinoplastoma و الـ p53 proteins
+
+94
+00:07:22,470 --> 00:07:29,010
+وبالتالي هي ليست الوظيفة وإنما مستوى أداء الوظيفة
+
+95
+00:07:29,010 --> 00:07:32,670
+هو الذي عمل فرق، كمان مرة ليست الوظيفة بحد ذاتها
+
+96
+00:07:32,670 --> 00:07:35,930
+وإنما مستوى أداء هذه الوظيفة
+
+97
+00:07:38,530 --> 00:07:43,230
+طبعًا هذا الكلام نحن نؤكد عليه عشان نفسر كثير
+
+98
+00:07:43,230 --> 00:07:48,850
+من الأشياء التي نحن قد يعني تشترك فيها الفيروسات
+
+99
+00:07:48,850 --> 00:07:52,910
+لكن الـ outcomes أو النتائج المخرجات تبعها تكون
+
+100
+00:07:52,910 --> 00:07:53,710
+مختلفة
+
+101
+00:07:56,260 --> 00:08:00,920
+طبعًا فينا كمان شغل مهم مثلها أنا أنه يقول لنا أن
+
+102
+00:08:00,920 --> 00:08:06,700
+اختلاف بسيط في الـ amino acid sequence أدى الاختلاف
+
+103
+00:08:06,700 --> 00:08:12,980
+في الـ antigenicity بين الـ HIV و الـ HTLV
+
+104
+00:08:13,690 --> 00:08:19,310
+ومثال ثاني بتأكيد على المثال الـ p24 is a major
+
+105
+00:08:19,310 --> 00:08:24,490
+nucleocapsid protein in both HTLV and HIV but they
+
+106
+00:08:24,490 --> 00:08:27,990
+differ antigenically لأنه قلنا لكم اختلاف بسيط في الـ
+
+107
+00:08:27,990 --> 00:08:34,230
+amino acid sequence الـ Variants لـ both HTLV and HIV
+
+108
+00:08:34,230 --> 00:08:36,710
+Contains a reverse transcriptase وحكينا على كلام
+
+109
+00:08:36,710 --> 00:08:40,510
+لكن كمان تحتوي Integrase و Protease ليش
+
+110
+00:08:40,510 --> 00:08:43,310
+Integrase؟ لأن احنا بدنا نعمل integration للجينوم
+
+111
+00:08:43,310 --> 00:08:47,590
+تبع الفيروس إلى داخل التي هو الـ host cell طب ليش
+
+112
+00:08:47,590 --> 00:08:51,910
+بدنا Protease؟ لأنه إذا فاكرين لما درسنا لبروتين
+
+113
+00:08:51,910 --> 00:08:56,170
+في الـ virus structure قلنا هناك بعض الفيروسات لا
+
+114
+00:08:56,170 --> 00:09:00,810
+تستطيع تستطيع أن تنتج functional protein، تنتجها
+
+115
+00:09:00,810 --> 00:09:05,730
+اسمها precursor polypeptide، فتحتاج البروتييز to
+
+116
+00:09:05,730 --> 00:09:09,910
+cut this precursor into functional proteins أو
+
+117
+00:09:09,910 --> 00:09:11,170
+polypeptide
+
+118
+00:09:13,250 --> 00:09:17,450
+الـ Envelope Protein في الـHTLV تحتوي على GP46 و
+
+119
+00:09:17,450 --> 00:09:23,430
+GP21 بينما في الـHIV تحتوي على GP120 و GP41 طبعًا
+
+120
+00:09:23,430 --> 00:09:26,050
+كل كلمة تحدث عن أن الـ Envelope Protein في
+
+121
+00:09:26,050 --> 00:09:33,730
+الـHTLV هم GP46 و GP21 هذول مقابلهم في الـHIV كان
+
+122
+00:09:33,730 --> 00:09:38,390
+فينا الـGP120 والـGP41 طبعًا هذول الـGlycoproteins
+
+123
+00:09:38,390 --> 00:09:42,570
+هم عبارة عن spikes على الـ envelopes وهم المسؤولين
+
+124
+00:09:42,570 --> 00:09:46,750
+عن الارتباط بالـ host cell التي هي الـCD4 في هذه
+
+125
+00:09:46,750 --> 00:09:54,610
+الحالة لأن نجي لـ regulatory proteins كنا فيه TAX
+
+126
+00:09:54,610 --> 00:09:59,420
+و فيه REX مظبوط مقابلها في الـHIV في حاسمة TAT
+
+127
+00:09:59,420 --> 00:10:03,520
+وحاسمة REV لحظة أنهم بيشتركوا بالأول حرفين
+
+128
+00:10:03,520 --> 00:10:10,220
+وبيختلفوا بالحرف التالت تاكس تات ريكس ريف تمام؟
+
+129
+00:10:10,220 --> 00:10:14,320
+الآن الـ Tax Protein هو الأهم على الإطلاق وحنشوف
+
+130
+00:10:14,320 --> 00:10:19,540
+الآن جداش مهمته في إحداث الكانسر مثلا بقولنا Tax
+
+131
+00:10:19,540 --> 00:10:22,560
+Protein is a transcriptional activator
+
+132
+00:10:24,810 --> 00:10:28,270
+بدي قبل ما أبدأ أشرح عنه بنتكلم على موضوع اللي هو
+
+133
+00:10:28,270 --> 00:10:32,910
+الـ viruses و إحداثها لانكوجين للـ human هذا هو
+
+134
+00:10:32,910 --> 00:10:36,430
+المعتاد اللي احنا بنعرفه في الـ onco viruses هذا ال
+
+135
+00:10:36,430 --> 00:10:41,190
+virus لا بيعمل هيك لا بيحمل انكوجين ولا بيعمل
+
+136
+00:10:41,190 --> 00:10:46,610
+insertion لانكو جنب انكوجين طبعا كيف بيشتغل؟ كل
+
+137
+00:10:46,610 --> 00:10:49,690
+اعتماد البناء العالمين على الـ tax protein اللي هو
+
+138
+00:10:49,690 --> 00:10:55,880
+transcriptional activator كيف بيشتغل؟ الـ
+
+139
+00:10:55,880 --> 00:10:58,940
+activation of transcription of both cellular and
+
+140
+00:10:58,940 --> 00:11:02,140
+viral mRNA synthesized by the tax protein that
+
+141
+00:11:02,140 --> 00:11:06,500
+initiate oncogenesis يبقى هو بيجي بينهم و بيمروا
+
+142
+00:11:06,500 --> 00:11:10,220
+على كل الجينات سواء كانت فيروسية أو أدمية و
+
+143
+00:11:10,220 --> 00:11:14,560
+بيعملها transcription بيعمل تنشيط لمين؟ للـ
+
+144
+00:11:14,560 --> 00:11:19,420
+transcription يبقى هتطلع بروتينات عديدة من ضمن هذه
+
+145
+00:11:19,420 --> 00:11:24,140
+البروتينات بنت الـ Interleukin-2 الـ Interlochen 
+
+146
+00:11:24,140 --> 00:11:29,120
+II قائد مهم جدا في جهاز المناعة لكن لابد أن يكون
+
+147
+00:11:29,120 --> 00:11:35,540
+قائد واحد بعدد محدود من الأوامر، تمام؟ لو صار عندنا
+
+148
+00:11:35,540 --> 00:11:40,580
+عشرة، عشرة قادة، وكل واحد بيعطي أوامر، تمام؟ أكيد
+
+149
+00:11:40,580 --> 00:11:45,300
+حيصير في عندنا خلل، بالإضافة إلى العاصفة اللي نتجت
+
+150
+00:11:45,300 --> 00:11:48,700
+عن كل البروتينات الجديدة اللي طلعت، اللي المفروض
+
+151
+00:11:48,700 --> 00:11:52,740
+ماتطلعش، طلعت لأنه في activator اللي موجود في هذا
+
+152
+00:11:52,740 --> 00:11:57,520
+الفيروس، فبصير في عندي hyper activity في الخلية
+
+153
+00:11:58,130 --> 00:12:01,470
+وانتوا عارفين أن الـ cancer cell uncontrolled
+
+154
+00:12:01,470 --> 00:12:06,630
+growth غير مسيطر عليه وهذا اللي بيحدث بالفعل في
+
+155
+00:12:06,630 --> 00:12:10,470
+الخلية، مين اللي بيساهم فيه؟ اللي هو الـ tax
+
+156
+00:12:10,470 --> 00:12:13,570
+protein اللي هو قابل عن الـ transcriptional
+
+157
+00:12:13,570 --> 00:12:18,700
+activator protein الآن في كامة نقطة مهمة لازم
+
+158
+00:12:18,700 --> 00:12:21,920
+نعرفها أن هذا الفيروس is much more stable أو
+
+159
+00:12:21,920 --> 00:12:26,900
+الجينات تبعته is much more stable than HIV هذه ال
+
+160
+00:12:26,900 --> 00:12:29,940
+stability في صالح مين؟ في صالح الـ HIV ولا في صالح
+
+161
+00:12:29,940 --> 00:12:30,660
+هذا الفيروس؟
+
+162
+00:12:33,300 --> 00:12:37,220
+أكيد في صالح الـ HIV الـ instability في صالح الفيروس
+
+163
+00:12:37,220 --> 00:12:42,100
+دايما ليش؟ لأنه دايما بيغير من من جيناته يبقى بيغير
+
+164
+00:12:42,100 --> 00:12:46,020
+من انتجناته لما بقول أن هذا الفيروس stable أو مش
+
+165
+00:12:46,020 --> 00:12:49,260
+stable بيكونوا يعرفوا أنه لها consequence الـ
+
+166
+00:12:49,260 --> 00:12:54,160
+stable يعني زي الـ smallpox stable الفيروس مالوش
+
+167
+00:12:54,160 --> 00:12:57,900
+الغير كان إيه one single strain هذا له two strains
+
+168
+00:12:57,900 --> 00:13:03,590
+إذا عرفناهم اللي هم HTLV-1 و HTLV-2 الصورة اللي
+
+169
+00:13:03,590 --> 00:13:07,950
+قدامنا اتطلع عليها منيح لو أنا مش مكتوب عليها كلام
+
+170
+00:13:07,950 --> 00:13:11,550
+هذا الكلام مش مكتوب عليها كان بقول يمكن هذا HIV
+
+171
+00:13:11,550 --> 00:13:15,510
+لأنهم بيشبهوا بعض كتير هم إيش الفرق بينهم فاكرين
+
+172
+00:13:15,510 --> 00:13:22,650
+الـ GP's GP 46 و GP وينه 21 تمام هدول اللي بيبقوا
+
+173
+00:13:22,650 --> 00:13:26,830
+معاهم بيرتبطوا ب الـ receptors اللي موجودة في الـ
+
+174
+00:13:26,830 --> 00:13:33,330
+CD4 plus cells كيف ينتقل هذا الفيروس؟ احنا بنعرف أن
+
+175
+00:13:33,330 --> 00:13:35,590
+الـHIV بينتقل عن طريق الـGens، بينتقل عن طريق
+
+176
+00:13:35,590 --> 00:13:38,910
+الدم، بينتقل عن طريق اللي هو الـ .. برضه الـ ..
+
+177
+00:13:38,910 --> 00:13:42,130
+أعتقد أنه نفس الـ .. نفس الفكرة انتقال، لكن
+
+178
+00:13:42,130 --> 00:13:45,890
+بالإضافة لذلك في عندي اللي هو الـbreast feeding من
+
+179
+00:13:45,890 --> 00:13:49,910
+رضاعة الطبيعي Intravenous drug use, sexual contact
+
+180
+00:13:49,910 --> 00:13:55,890
+or breast feeding هناك بعض إثباتات غير مؤكدة بإنه
+
+181
+00:13:55,890 --> 00:13:59,030
+ممكن ينتقل الـtrans placental من الأم إلى الجنين
+
+182
+00:14:00,890 --> 00:14:03,950
+الترانسبيشن عبر البلد مدى ما بينتقل عن طريق الـ
+
+183
+00:14:03,950 --> 00:14:06,850
+drug .. drug intravenous drug use بجهة أكيد بينتقل
+
+184
+00:14:06,850 --> 00:14:10,090
+عن طريق الـ blood transfusion لكن في بنوك الدم في
+
+185
+00:14:10,090 --> 00:14:12,470
+تلك البلدان اللي فيها هذا الفيروس المنتشر بشكل
+
+186
+00:14:12,470 --> 00:14:16,710
+كبير أصبح جزء من الـ screening للـ blood bags أن
+
+187
+00:14:16,710 --> 00:14:22,120
+نفحص عن الـ antibodies تبع الـ HTLV فأي blood bag
+
+188
+00:14:22,120 --> 00:14:26,240
+فحصة positive لهذا الفيروس it will be discarded
+
+189
+00:14:26,240 --> 00:14:31,000
+وبالتالي عدد حالة الانتقال عبر الـ blood transfusion
+
+190
+00:14:31,000 --> 00:14:35,740
+لهذا المرة تقريبا zero Transmission is thought to
+
+191
+00:14:35,740 --> 00:14:39,500
+occur هذه نقطة كتير برضه مهمة يعني برضه غريبة أن
+
+192
+00:14:39,500 --> 00:14:44,220
+الـ virus بينتقلش بشكل حر يا بنات بينتقل عبر خلية
+
+193
+00:14:44,220 --> 00:14:49,340
+مصابة إذا يجب أن ينتقل من إنسان إلى إنسان تمام
+
+194
+00:14:49,340 --> 00:14:54,280
+لإنفساعة مصابة Lymphocyte مصابة مش الفيروس الـ free
+
+195
+00:14:54,280 --> 00:15:01,040
+وإنما الـ lymphocyte مثلا بقولنا أنه في المثال اللي
+
+196
+00:15:01,040 --> 00:15:04,660
+أعتقد اللي وراه على طول الـ whole blood مش الـ
+
+197
+00:15:04,660 --> 00:15:09,300
+plasma اللي بتنجل الفيروس كمان الـ infected
+
+198
+00:15:09,300 --> 00:15:13,420
+lymphocyte في السائل المنوي هي المسئولة عن نقل
+
+199
+00:15:13,420 --> 00:15:18,500
+الفيروس عبر اللي هو الـ sexual contact، إذا خلايا
+
+200
+00:15:18,500 --> 00:15:23,940
+مصابة وليست فيروسات حرة هي المسئولة عن الانتقال
+
+201
+00:15:24,980 --> 00:15:28,140
+هناك مناطق عالميا معروفة أن فيها نسبة عالية من هذا
+
+202
+00:15:28,140 --> 00:15:30,660
+الفيروس زي الـ Caribbean Region في Southern
+
+203
+00:15:30,660 --> 00:15:33,800
+Florida و Eastern South America في Western Africa
+
+204
+00:15:33,800 --> 00:15:37,880
+و Southern Japan لكن على الرغم من أن في هذه
+
+205
+00:15:37,880 --> 00:15:41,640
+البلدان أو هذه المناطق يعني قد تصل نسبة الإصابة
+
+206
+00:15:41,640 --> 00:15:47,880
+إلى عشرين بالمائة من السكان إلا إنه مش لازم نغفل أن
+
+207
+00:15:47,880 --> 00:15:51,420
+هؤلاء الناس في تلك المناطق لن يبقوا في تلك
+
+208
+00:15:51,420 --> 00:15:54,620
+المناطق، يعني هم بيتحركوا، بيسافروا، بيهاجروا،
+
+209
+00:15:54,620 --> 00:15:58,180
+ممكن يقضوا أو قط، أوطل هنا أو هناك، وبالتالي هم
+
+210
+00:15:58,180 --> 00:16:03,020
+ناقلين للفيروس، يعني نقدر نقول أن الفيروس should
+
+211
+00:16:03,020 --> 00:16:09,860
+be expected all over the world ولا نص المصابين اللي
+
+212
+00:16:09,860 --> 00:16:12,220
+كانوا في ولاية المتحدة، مش نص ولاية المتحدة، نص
+
+213
+00:16:12,220 --> 00:16:16,020
+المصابين من ولاية المتحدة كانوا مصابين بالنسخة
+
+214
+00:16:16,020 --> 00:16:22,500
+التانية اللي هي الـHTLV2 واللي غالبا تنتقل عبر
+
+215
+00:16:22,500 --> 00:16:25,820
+الـIntravenous Drug Use، يعني تبعهم المخدرات هم
+
+216
+00:16:25,820 --> 00:16:29,560
+اللي بيصابوا بهذا الفيروس
+
+217
+00:16:32,280 --> 00:16:36,760
+احنا ذكرنا في المقدمة أنه في مرضين مهمين ومنفصلين
+
+218
+00:16:36,760 --> 00:16:41,360
+تماما بسببهم هذا الفيروس اللي هم الـ other T cell
+
+219
+00:16:41,360 --> 00:16:46,860
+leukemia أو ATL والـHTLV infection للـ CD4 T
+
+220
+00:16:46,860 --> 00:16:49,500
+lymphocyte بيعمل malignant transformation يعني
+
+221
+00:16:49,500 --> 00:16:54,700
+cancer يعني cancer والـHTLV في هذه الحالة latent
+
+222
+00:16:54,700 --> 00:16:58,420
+within the malignant cells هذا اللي .. هذا ال ..
+
+223
+00:16:58,420 --> 00:17:01,640
+ال .. ال .. ال .. ال ..اللي بيخلّي الكلام اللي
+
+224
+00:17:01,640 --> 00:17:05,300
+احنا حكيناه قبل قليل يكون له معنى أن الانتقال عبر
+
+225
+00:17:05,300 --> 00:17:09,380
+الـ lymphocytes وليس عبر اللي هو قولنا ال .. ال
+
+226
+00:17:09,380 --> 00:17:13,080
+.. نعم لأن
+
+227
+00:17:13,080 --> 00:17:16,440
+الـHTLV is typically not produced by the malignant
+
+228
+00:17:16,440 --> 00:17:20,180
+cell إذا الخلية صارت malignant، غالباً الفيروس ما
+
+229
+00:17:20,180 --> 00:17:24,680
+.. يعني مابيطلعش منها، بيظل موجود جوا، ليش؟ لأنه
+
+230
+00:17:24,680 --> 00:17:31,310
+هي لما بتتكاثر، هو الـ Provirus بتكثر مع هذه الخلية
+
+231
+00:17:31,310 --> 00:17:35,530
+الشكل
+
+232
+00:17:35,530 --> 00:17:38,310
+التاني من المعروف اللي قلنا سميناه HAM أو HTLV
+
+233
+00:17:38,310 --> 00:17:41,670
+-associated myelopathy الاحتلال العصبي المصاحب
+
+234
+00:17:41,670 --> 00:17:45,750
+لفيروس الـ HTLV وقلنا له أسماء أخرى tropical
+
+235
+00:17:45,750 --> 00:17:49,050
+spastic paraparesis paraparesis معناها ارتخاء
+
+236
+00:17:49,050 --> 00:17:53,810
+عضلات أو شلل و spastic معناها انقباضي أو chronic
+
+237
+00:17:54,780 --> 00:17:58,560
+progressive myelopathy وكلمة chronic يعني مزمن
+
+238
+00:17:58,560 --> 00:18:03,160
+يعني طويل الأمد progressive بيصيب الإنسان في لحظة
+
+239
+00:18:03,160 --> 00:18:07,700
+معينة باعتلال بسيط وبيتطور هذا الاعتلال وبيزداد مع
+
+240
+00:18:07,700 --> 00:18:13,050
+إيه مع الزمن لكن على فترة طويلة كمان الـHAM عبارة عن
+
+241
+00:18:13,050 --> 00:18:17,170
+demyelinating disease لكل من الدماغ و الـ spinal
+
+242
+00:18:17,170 --> 00:18:22,590
+cord ويؤثر أكثر على الـ motor neurons ولما يؤثر
+
+243
+00:18:22,590 --> 00:18:26,510
+على الـ motor neurons اللي هي الخلايا العصبية
+
+244
+00:18:26,510 --> 00:18:31,530
+الحركية أكيد برضه هيؤثر على الشلل أو يعمل الشلل
+
+245
+00:18:31,530 --> 00:18:42,670
+الآن بدنا نفهم النظرية اللي بتفسر حدوث الـHAM وهي
+
+246
+00:18:42,670 --> 00:18:47,870
+تتنافع مع ممكن كلام ذكرناه سابقا فهنحاول نوفق بين
+
+247
+00:18:47,870 --> 00:18:53,890
+المعناين بطريقة ما HAM is caused by an autoimmune
+
+248
+00:18:53,890 --> 00:18:57,470
+cross reaction autoimmune cross reaction يعني
+
+249
+00:18:57,470 --> 00:19:03,550
+المفروض أن الـ antibodies الموجهة للفيروس ماترتبطش
+
+250
+00:19:03,550 --> 00:19:08,050
+مع مين؟ مع خلايانا لكن كلمة cross reaction معناها
+
+251
+00:19:08,050 --> 00:19:11,580
+الحاجة أنه صار في ارتباط in which the immune
+
+252
+00:19:11,580 --> 00:19:16,980
+response against HTLV damages the neuron or، هذا
+
+253
+00:19:16,980 --> 00:19:21,740
+احتمال ثاني، by cytotoxic T-cells that kills HTLV 
+
+254
+00:19:21,740 --> 00:19:25,060
+infected neurons احنا بنعرف أنه الجهاز العصبي
+
+255
+00:19:25,060 --> 00:19:31,210
+في الإنسان من الأماكن المحمية من جهاز المناعة ويمكن
+
+256
+00:19:31,210 --> 00:19:33,990
+ذكرنا هذا الكلام في نقاش سابق أن it is protected
+
+257
+00:19:33,990 --> 00:19:37,290
+لأن أي فيروس بدي يصلي هنا الخلايا هذه ويصلي ال
+
+258
+00:19:37,290 --> 00:19:42,110
+toxic T cell تيجي تدمره إذا دمرته معناه الحكي أنه
+
+259
+00:19:42,110 --> 00:19:46,330
+فينا خلل لأن الخلية العصبية اللي بتموت ما فيش غيرها،
+
+260
+00:19:46,330 --> 00:19:52,850
+مظبوط؟ فهو من ال privileged site في الجسم
+
+261
+00:19:53,630 --> 00:19:57,770
+لكن لما ييجي antibody cross-reacting ويرتبط فيه
+
+262
+00:19:57,770 --> 00:20:03,650
+الارتباط بيعمل marking الليمفوسيات ما بتفهمش كتير إلا
+
+263
+00:20:03,650 --> 00:20:08,130
+إشارات معينة فال mark هذه أن هذا ال antibody مرتبط
+
+264
+00:20:08,130 --> 00:20:11,510
+بهذه الخلية يبقى هذه mark أو اشارة لل T cell تعطي
+
+265
+00:20:11,510 --> 00:20:15,750
+T cell اقتل هذه الخلية فهذا قد يكون السبب أن في ال
+
+266
+00:20:15,750 --> 00:20:19,450
+cross reaction ذهبت ال antibodies إلى ال neurons
+
+267
+00:20:19,450 --> 00:20:24,950
+وبالتالي أعطت wrong information ل ال T cells اللي
+
+268
+00:20:24,950 --> 00:20:26,330
+قتلت هذه ال neurons
+
+269
+00:20:29,980 --> 00:20:33,940
+لـ Clinical findings الـ ATL is characterized by
+
+270
+00:20:33,940 --> 00:20:37,660
+lymphadenopathy, hepatosplenomegaly, lytic bone,
+
+271
+00:20:38,280 --> 00:20:42,880
+bone lesions, and skin lesions كل هذه الـ lesions اللي
+
+272
+00:20:42,880 --> 00:20:46,240
+حكينا عنها والهيباتوميجالي والاسبينوميجالي ناتجة
+
+273
+00:20:46,240 --> 00:20:51,700
+عن تكاثر اللي هو الـ T cell infiltrating these
+
+274
+00:20:51,700 --> 00:20:56,360
+organs عشان infiltrating تتسلل إلى هذه الأعضاء
+
+275
+00:20:58,570 --> 00:21:04,090
+في الدم الـ malignant T cell لها شكل حلو كتير بيسموه
+
+276
+00:21:04,090 --> 00:21:08,070
+flower-shaped nucleus هنشوف صورة كمان شوية له صورة
+
+277
+00:21:08,070 --> 00:21:13,530
+جميلة لمرض خبيث hypercalcemia due to increased
+
+278
+00:21:13,530 --> 00:21:15,850
+osteoclastic activity شوفتوا قبل شوية احنا اتكلمنا
+
+279
+00:21:15,850 --> 00:21:20,070
+عن مين؟ عن lytic bone صح؟ فالـ lytic bone يعني فيه
+
+280
+00:21:20,070 --> 00:21:23,790
+أن خلايا عظمية بتتحلل خلايا عظمية بتتحلل ليش بيطلع
+
+281
+00:21:23,790 --> 00:21:27,230
+منها كالسيوم فبيصير لنا نسبة كالسيوم عالية في هذا
+
+282
+00:21:27,230 --> 00:21:32,490
+الحال Patients with ATL often have reduced cell
+
+283
+00:21:32,490 --> 00:21:37,570
+-mediated immunity. عظم اني لما بنقول CD4 cells صار
+
+284
+00:21:37,570 --> 00:21:41,350
+فيها infection قل عددها السليمة يبقى معناه الحكي
+
+285
+00:21:41,350 --> 00:21:43,730
+أن هو بالفعل في عندي reduced cell-mediated
+
+286
+00:21:43,730 --> 00:21:48,630
+immunity وبالتالي هو الآن قريب لأخو ال HIV أنه
+
+287
+00:21:48,630 --> 00:21:52,850
+بيخفض جهاز المناعة طبعا لكن فعال أكثر اللي هو ال HIV
+
+288
+00:21:52,850 --> 00:21:56,270
+more effective in reducing immunity than this
+
+289
+00:21:56,270 --> 00:22:00,310
+disease طب يتصور عندنا cell-mediated الـ immunity
+
+290
+00:22:00,310 --> 00:22:04,850
+depressed بيصير عندي opportunistic infection with
+
+291
+00:22:04,850 --> 00:22:10,520
+fungi and other viruses ال clinical picture of HAM
+
+292
+00:22:10,520 --> 00:22:13,960
+include gait وكلمة gait معناها walking
+
+293
+00:22:13,960 --> 00:22:20,500
+disturbances يعني مشكلة في الحركة وهذا نتج عن ضعف
+
+294
+00:22:20,500 --> 00:22:26,900
+العضلات اللي بتصيب ال lower limbs اللي هي الأطراف
+
+295
+00:22:26,900 --> 00:22:33,830
+السفلية وأيضا يصاحب ذلك low back pain ممكن يكون فيه
+
+296
+00:22:33,830 --> 00:22:39,030
+فقدان للسيطرة على التبول والبراز في بعض الحالات
+
+297
+00:22:39,030 --> 00:22:44,850
+أيضا كما ذكرنا في السابق أن فقدان الخلايا الحركية
+
+298
+00:22:44,850 --> 00:22:50,250
+بيكون لصالح أو فقدان الحركة أكثر من فقدان الإحساس
+
+299
+00:22:50,250 --> 00:22:53,810
+في هذه الحالة لأنه تأثير أكثر على ال motor neuron
+
+300
+00:22:55,070 --> 00:22:58,130
+هذه الصورة اللي ذكرناها قبل قليل قلنا لكم أن ال
+
+301
+00:22:58,130 --> 00:23:03,570
+nucleus بتكون عاملة زي الزهرة تمام فصورة جميلة
+
+302
+00:23:03,570 --> 00:23:11,050
+لكنها لمرض خبيث لأن هذا cancer طبعا ال ... ال ... ال
+
+303
+00:23:11,050 --> 00:23:12,950
+... الـ T cell flower shape nucleus can also be
+
+304
+00:23:12,950 --> 00:23:16,630
+found in the spinal fluid، magnetic resonance
+
+305
+00:23:16,630 --> 00:23:19,450
+imaging اللي هو ال MRI، بتسمعوا بال MRI؟ اللي هي
+
+306
+00:23:19,450 --> 00:23:23,190
+تصوير ال ... ال ... ال ... الرنين، تصوير الرنين،
+
+307
+00:23:23,190 --> 00:23:27,650
+ما أعطيناش أي specific findings، يعني بنشوف ال ... أو
+
+308
+00:23:27,650 --> 00:23:30,410
+ال ... ال ... الطبيب اللي عشانها، بيشوف إن هو هذا
+
+309
+00:23:30,410 --> 00:23:34,450
+المريض normal في الغالب Progression of symptoms
+
+310
+00:23:34,450 --> 00:23:37,930
+occur slowly or over a period of years يعني في بطء
+
+311
+00:23:37,930 --> 00:23:42,750
+زي ما ذكرنا أو على مدار سنوات طويلة HAM occur
+
+312
+00:23:42,750 --> 00:23:48,440
+primarily in women of middle age منتصف العمر، the
+
+313
+00:23:48,440 --> 00:23:51,900
+disease resembles multiple sclerosis، فيه فرق بين
+
+314
+00:23:51,900 --> 00:23:55,960
+multiple sclerosis وبين هذا ال disease، أن هذاك
+
+315
+00:23:55,960 --> 00:23:59,300
+بيشفى، ال multiple sclerosis فيه remission، بينما
+
+316
+00:23:59,300 --> 00:24:03,240
+هذا المرض ما بيصير فيه أن remission، غالبا التطور
+
+317
+00:24:03,240 --> 00:24:09,060
+بيكون إلى الأسوأ ATL and HAM are relatively rare
+
+318
+00:24:09,060 --> 00:24:11,460
+diseases فاكرين لما قلت أن إصاب شوية عشرين بالمية
+
+319
+00:24:11,460 --> 00:24:14,480
+في بعض المناطق؟ العشرين بالمية لا تعني أن كل
+
+320
+00:24:14,480 --> 00:24:19,980
+العشرين بالمية سيتحولوا إليه اللي هو ATL أو HAM،
+
+321
+00:24:19,980 --> 00:24:25,320
+نسبة ضئيلة من هؤلاء المرضى ممكن يطوروا ATL أو HAM
+
+322
+00:24:26,220 --> 00:24:29,040
+The vast majority of people infected with HTLV
+
+323
+00:24:29,040 --> 00:24:32,980
+develop asymptomatic infection, usually detected
+
+324
+00:24:32,980 --> 00:24:35,840
+by the presence of antibody. أصلا كيف أنا أفهم أن
+
+325
+00:24:35,840 --> 00:24:40,920
+20% من الناس من خلال الـ routine testing of blood donors
+
+326
+00:24:40,920 --> 00:24:44,680
+لما بيجينا blood donor احنا مش بنفحصه احنا لل HIV
+
+327
+00:24:44,680 --> 00:24:48,420
+مثلا في غزة هنا و لـ Hepatitis B و لـ Hepatitis C
+
+328
+00:24:48,420 --> 00:24:51,500
+وعرفش إذا كان بيفحصه لأشياء أخرى بس أنا أعتقد أن
+
+329
+00:24:51,500 --> 00:24:54,930
+هذه الأمراض اللي بيفحصوها routinely الأقل لو كان
+
+330
+00:24:54,930 --> 00:24:59,690
+عندنا HTLV الـ human T cell نعم ال ... ال ...
+
+331
+00:24:59,690 --> 00:25:04,190
+الليمفوسايت جنهة فيروس وكانت تستنج ابنين دي لما
+
+332
+00:25:04,190 --> 00:25:08,170
+نعرف جداش ال population اللي كان عندهم Antibody من
+
+333
+00:25:08,170 --> 00:25:12,470
+خلال الـ blood testing للـ blood donors وهذا الكلام
+
+334
+00:25:12,470 --> 00:25:16,630
+بيسويه في كثير في مدن العالم أن بدل ما ياخدوا
+
+335
+00:25:16,630 --> 00:25:19,170
+عينات من ... وناس عاديين بيروح على بنك ... على
+
+336
+00:25:19,170 --> 00:25:23,690
+بنك الدم وبيقعدوا هناك بنك الدم الباحثين و بيدوروا
+
+337
+00:25:23,690 --> 00:25:26,870
+على ال prevalence of diseases من خلال الـ blood
+
+338
+00:25:26,870 --> 00:25:30,070
+وأنا أقول إنهم معينة ممثل عالمين عن المجتمع اللي
+
+339
+00:25:30,070 --> 00:25:36,110
+هم موجودين فيه okay only a small subset of those
+
+340
+00:25:36,110 --> 00:25:39,590
+infected will develop either ATL or HAM إذا النسبة
+
+341
+00:25:39,590 --> 00:25:44,450
+ضئيلة من هؤلاء الذين يصابون قد يطوروا ATL أو HAM
+
+342
+00:25:45,820 --> 00:25:50,880
+الـ lab diagnosis لهذه المرضين ممكن نكشف عنهم من
+
+343
+00:25:50,880 --> 00:25:54,260
+خلال الـ ELISA test to detect antibodies in
+
+344
+00:25:54,260 --> 00:25:57,900
+patient serum، إذا فهي إمكانية لقياس الـ antibody
+
+345
+00:25:58,810 --> 00:26:02,270
+طبعا زي ما ال HIV الـ Western blot هو ال
+
+346
+00:26:02,270 --> 00:26:06,690
+confirmatory test أيضا هو هنا الـ confirmatory test
+
+347
+00:26:06,690 --> 00:26:10,050
+انتوا عارفين ELISA في كثير من الفحوصات تعتبر
+
+348
+00:26:10,050 --> 00:26:14,170
+screening كده بدنا نعمل confirmation بدنا نعمل
+
+349
+00:26:14,170 --> 00:26:17,570
+Western blot في هذا الحال is used to confirm a
+
+350
+00:26:17,570 --> 00:26:21,240
+positive ELISA result إذاً الـ ELISA لو جالت
+
+351
+00:26:21,240 --> 00:26:23,520
+negative فهو negative، لكن لو positive، it should
+
+352
+00:26:23,520 --> 00:26:27,640
+be confirmed by Western blot عشان هي كبنات لازم
+
+353
+00:26:27,640 --> 00:26:32,020
+يكونوا عارفين في مستويات التقارير، التحاليل،
+
+354
+00:26:32,020 --> 00:26:38,090
+ما ينفعش نستعجل ونعطي المرضى نتائج يعني في بعض ...
+
+355
+00:26:38,090 --> 00:26:42,790
+في حالة أذكرها جيدا طلعت عنها في أحد المختبرات و
+
+356
+00:26:42,790 --> 00:26:46,830
+أنا كنت أشعر أعمل في ذاك المختبر طلعت عنها VDRL أو
+
+357
+00:26:46,830 --> 00:26:49,890
+RPR بتاعة الـ syphilis طلعت positive لفتاة في
+
+358
+00:26:49,890 --> 00:26:53,670
+الثامن عشر من عمرها كانوا مسافرين على كندا وفي
+
+359
+00:26:53,670 --> 00:26:58,450
+الإجراءات ... في إجراءات لازم نعمل testing ...
+
+360
+00:26:58,450 --> 00:27:01,750
+testing للأشخاص اللي جابوا ياخدوا ال visa لمجموعة
+
+361
+00:27:01,750 --> 00:27:05,390
+من الأعمار ومنها ال syphilis تمام؟ فطلع من دون أن
+
+362
+00:27:05,390 --> 00:27:10,260
+عن العائلة تبعها كلها طلعت positive فلما جابولي
+
+363
+00:27:10,260 --> 00:27:13,860
+الأمضاء التقارير فبقولهم أنتو عملتوا confirmation
+
+364
+00:27:13,860 --> 00:27:18,000
+جانوا لأ طب قلت له ما نعرفش يعني تعطي نتيجة لأنثى
+
+365
+00:27:18,000 --> 00:27:20,420
+في قطاع غزة أو تكون syphilis positive ما نعرفش
+
+366
+00:27:20,420 --> 00:27:24,160
+يعني يعني ما تروحش على البيت ممكن تقتل صح ولا مش صح
+
+367
+00:27:24,160 --> 00:27:27,560
+فأبقينا
+
+368
+00:27:27,560 --> 00:27:31,800
+النتيجة أخرنا ظهور نتيجة لعبارة عن ما عملنا
+
+369
+00:27:31,800 --> 00:27:34,420
+confirmatory test فقلت له الفحص negative فحص
+
+370
+00:27:34,420 --> 00:27:38,660
+negative في في دائما في في ال ... في ال screening
+
+371
+00:27:38,660 --> 00:27:44,360
+test بيكون فيها اسمها non-specific results وإلا
+
+372
+00:27:44,360 --> 00:27:48,300
+كان ما اضطرناش نعمل confirmation إذا ال negative
+
+373
+00:27:48,300 --> 00:27:50,400
+negative بس ال positive لازم نعمله إيه
+
+374
+00:27:50,400 --> 00:27:54,100
+confirmation فنرجو منكم الموقف اللي ذكرته هذا
+
+375
+00:27:54,100 --> 00:27:58,940
+ناخذه على سبيل المثال والمواضع في التأني و 
+
+376
+00:27:58,940 --> 00:28:03,940
+التفكير قبل إصدار بعض النتائج في تحليل الطبيب
+
+377
+00:28:08,410 --> 00:28:12,950
+Okay, PCR assay can detect the presence of HTLV RNA
+
+378
+00:28:12,950 --> 00:28:17,150
+or DNA within infected cells. يعني ممكن لو أخدنا ال
+
+379
+00:28:17,150 --> 00:28:20,350
+buffer coat layer من الدم تبعت المريض و أخدنا ال
+
+380
+00:28:20,350 --> 00:28:23,870
+white blood cell نعمل extraction لل DNA أو ال RNA
+
+381
+00:28:23,870 --> 00:28:27,950
+و نقدر نكشف عن اللي هو الفيروس. the test used to
+
+382
+00:28:27,950 --> 00:28:31,010
+screen the red blood cells contains only هذه المعلومة
+
+383
+00:28:31,010 --> 00:28:38,070
+منّيها أنا بكشف عن ال blood bag, باكشف عن antibodies
+
+384
+00:28:38,070 --> 00:28:44,130
+لمين؟ لل HTLV-1. طب و ال HTLV-2؟ طب ما هو بتاني 
+
+385
+00:28:44,130 --> 00:28:48,850
+بيسبب نفس الأمراض قبل قليل، وإن كان وإن كان الدلائل
+
+386
+00:28:48,850 --> 00:28:53,570
+مش مؤكدة إن هو اللي بيسبب، لكن المعلم بفترض إن هو
+
+387
+00:28:53,570 --> 00:28:56,790
+اللي بيسبب، وبتاني لازم نبحث عنه. هبقول إن أنا
+
+388
+00:28:56,790 --> 00:29:01,210
+بستخدم antigen ل HTLV-1، لكن هذا ال antigen اللي
+
+389
+00:29:01,210 --> 00:29:06,690
+حصل حظنا كان cross react with اللي هو HTLV-2 فقد
+
+390
+00:29:06,690 --> 00:29:12,410
+أكشف أنا HTLV-2 أو HTLV-1، و أنا مش عارف من هما، لكن
+
+391
+00:29:12,410 --> 00:29:17,230
+positive لأي من هما، لكن للأسف هذا الفحص أيضًا في
+
+392
+00:29:17,230 --> 00:29:22,110
+بعض العيوب، أنه بيفقد بعض ال HTLV-2، إذا بعض الحالات
+
+393
+00:29:22,110 --> 00:29:27,530
+قد يفقدها. إذا الفحص تبعنا هنا مش sensitive للتنين
+
+394
+00:29:27,530 --> 00:29:31,310
+وإنما sensitive لمن؟ لل HTLV-1 فقط.
+
+395
+00:29:35,650 --> 00:29:39,850
+ال isolation لل HTLV in cell culture is not done، و
+
+396
+00:29:39,850 --> 00:29:43,930
+السبب المفروض أنكم تكونوا فاهمته الآن، لأنه
+
+397
+00:29:43,930 --> 00:29:47,790
+ما بيتكاثرش تكاثر طبيعي في الخلايا، وإنما بيعمل
+
+398
+00:29:47,790 --> 00:29:52,320
+transformation. بيعمل transformation. ATL is
+
+399
+00:29:52,320 --> 00:29:55,380
+diagnosed by finding malignant T-cells in the
+
+400
+00:29:55,380 --> 00:29:58,440
+lesions. يعني لو شوفنا خلايا سلطانية في الـ lesions
+
+401
+00:29:58,440 --> 00:30:02,680
+الشكل اللي احنا شوفناه قبل قليل، هذا مميز إلينا.
+
+402
+00:30:02,680 --> 00:30:05,280
+الـdiagnosis of HAM is supported by the presence
+
+403
+00:30:05,280 --> 00:30:08,760
+of HTLV antibodies in the spinal fluid. يعني إذا
+
+404
+00:30:08,760 --> 00:30:13,380
+بناخد عينات من وين؟ من الـCSF أو finding HTLV
+
+405
+00:30:13,380 --> 00:30:17,430
+nucleic acid in cells in the spinal fluid. إيش كيف
+
+406
+00:30:17,430 --> 00:30:22,950
+نجد الـ Nucleic Acid؟ من خلال الـ PCR اللي حكينا
+
+407
+00:30:22,950 --> 00:30:28,710
+عنه قبل قليل. ال treatment and prevention. There is
+
+408
+00:30:28,710 --> 00:30:32,310
+no specific antiviral treatment of HTLV infection
+
+409
+00:30:32,310 --> 00:30:36,310
+and no antiviral drugs. يعني لا إله vaccine ولا إله
+
+410
+00:30:36,310 --> 00:30:39,330
+antiviral
+
+411
+00:30:39,330 --> 00:30:43,610
+drug will cure latent infection by HTLV. خاصة أنه
+
+412
+00:30:43,610 --> 00:30:45,750
+احنا بنتكلم عن latent infection، و هذا الكلام
+
+413
+00:30:46,190 --> 00:30:49,790
+كررناها زمان لما قلنا لكوا إنه حتى بقى Cyclovere
+
+414
+00:30:49,790 --> 00:30:52,470
+اللي كنا بنستخدمه للـ .. للـ .. للـ .. ال herpes
+
+415
+00:30:52,470 --> 00:30:56,190
+simplex type 1 و type 2 و لـ الـ .. ال CMV. Okay,
+
+416
+00:30:56,190 --> 00:31:00,310
+ممكن يخفف من الأعراض، ممكن يشيل ال virus اللي ..
+
+417
+00:31:00,310 --> 00:31:02,790
+اللي عامل ال infection الآن، لكن ولا بأي حال من
+
+418
+00:31:02,790 --> 00:31:06,830
+الأحوال يستطيع أن يتخلص من ال tendency تبع ال
+
+419
+00:31:06,830 --> 00:31:12,050
+virus. ATL is treated with anticancer chemotherapy
+
+420
+00:31:12,050 --> 00:31:14,910
+regimen. يعني بعمله كأنه cancer و انتهى الموضوع.
+
+421
+00:31:15,590 --> 00:31:18,150
+Antiviral drugs have not been effective in the
+
+422
+00:31:18,150 --> 00:31:23,310
+treatment of HAM. Corticosteroid and denasol have
+
+423
+00:31:23,310 --> 00:31:27,010
+produced improvement in some patients. يعني عملوا
+
+424
+00:31:27,010 --> 00:31:31,310
+خلطة بين ال corticosteroid و ال denasol و أعطت بعض
+
+425
+00:31:31,310 --> 00:31:36,170
+التحسن في بعض المرضى. لحظة، كان مرة التواضع في لو
+
+426
+00:31:36,170 --> 00:31:41,410
+احنا اللي جينا حالة تحسن بنضخمها، بس هنا لازم نكون
+
+427
+00:31:41,410 --> 00:31:45,570
+موضوعيين بالفعل و نقول إن النتائج تبعاتنا لم تعطي
+
+428
+00:31:45,570 --> 00:31:49,130
+تلك النتيجة للعالم. There is no vaccine in H أو
+
+429
+00:31:49,130 --> 00:31:54,250
+against HTLV. ال prevention strategies و احنا
+
+430
+00:31:54,250 --> 00:31:57,110
+قلنالكم إنه كتير من الأمراض اللي يصعب علاجها
+
+431
+00:31:57,110 --> 00:32:04,110
+مائلنا إلا غير إنه نشوف الإجراءات المتبعة في عملية
+
+432
+00:32:04,110 --> 00:32:07,650
+اللي هو ال prevention، و ال prevention على فكرة
+
+433
+00:32:07,650 --> 00:32:15,550
+يعني إيه؟ استراتيجية رايعة جدا وممكن احنا اللي كان
+
+434
+00:32:15,550 --> 00:32:17,890
+المفروض اليوم نعمل يوم دراسي عن ال infection
+
+435
+00:32:17,890 --> 00:32:21,270
+control، وفي خضم الانشغال في أسبوع المضاد الحيوي
+
+436
+00:32:21,270 --> 00:32:25,370
+نسينا الموضوع خالص وما .. ماتبنروش. فاحتمال يعني
+
+437
+00:32:25,370 --> 00:32:27,250
+على .. على نهاية الامتحانات تبعتكم إن شاء الله
+
+438
+00:32:27,250 --> 00:32:30,790
+نعمل يوم دراسي عن ال infection control ودوره
+
+439
+00:32:30,790 --> 00:32:33,990
+و أدواته، ويعني أشياء متعلقة بال infection control
+
+440
+00:32:33,990 --> 00:32:36,910
+فإن شاء الله إذا كان في نصيب يعني تحضر هذا اليوم
+
+441
+00:32:36,910 --> 00:32:39,090
+الدراسي بيكون استفدت إن شاء الله .. إن شاء الله
+
+442
+00:32:39,090 --> 00:32:44,270
+كويس. فبنقول إن ال infection control إلها آثار
+
+443
+00:32:44,270 --> 00:32:48,590
+إيجابية في منع الأمراض المعدية بشكل كبير، ويجب أن
+
+444
+00:32:48,590 --> 00:32:52,010
+لا نستهين بها، وخاصة في الأمراض التي لا يمكن
+
+445
+00:32:52,010 --> 00:32:57,510
+علاجها بطريقة سهلة ومعسرة. Screening donated blood
+
+446
+00:32:57,510 --> 00:33:00,310
+for the presence of antibodies. هذي أثبتت فعالية
+
+447
+00:33:00,310 --> 00:33:04,850
+كويسة لمنع اللي هو انتقال المرض عبر ال blood
+
+448
+00:33:04,850 --> 00:33:08,070
+transfusion. يا هل طبعًا ال blood transfusion هل هو
+
+449
+00:33:08,070 --> 00:33:12,150
+حجمه كبير كثير في الدنيا عشان نهتم فيه لها درجة
+
+450
+00:33:12,150 --> 00:33:16,380
+هذي؟ نعماسألوا بنك الدم في أي مستشفى من المستشفات،
+
+451
+00:33:16,380 --> 00:33:19,960
+قولوا حجم التبادل في الدم عندكم من جداش، بيقولوا
+
+452
+00:33:19,960 --> 00:33:22,960
+إن نسبته عالية جدا. الآن العملية الجراحية لازم يكون
+
+453
+00:33:22,960 --> 00:33:28,740
+في blood، يعني احتياط في هذه العملية. Using condoms
+
+454
+00:33:28,740 --> 00:33:31,800
+to prevent sexual transmission. يعني احتياطات أو
+
+455
+00:33:31,800 --> 00:33:35,340
+الجنس الأمن يسموها. Encouraging women with HTLV
+
+456
+00:33:35,340 --> 00:33:38,420
+antibodies to refrain from breastfeeding. يعني لو
+
+457
+00:33:38,420 --> 00:33:43,920
+كانت أم صابة أو عندها antibodies لهذا الفيروس إنه
+
+458
+00:33:43,920 --> 00:33:46,540
+تمتنع عن الرضاعة الطبيعية وتستبدلها بالرضاعة
+
+459
+00:33:46,540 --> 00:33:50,680
+الصناعية. هيك بنقول احنا إنتهينا من مجموعة اسمها
+
+460
+00:33:50,680 --> 00:33:57,560
+RNA Enveloped Virus. طبعًا إذا لاحظتوا إن الـHIV
+
+461
+00:33:57,560 --> 00:34:02,060
+المفروض يكون من ضمن المجموعة، بس مدرس نهوش، وبتالي
+
+462
+00:34:02,060 --> 00:34:05,360
+هذا أكيد إله ماله، إله وضع خاص، فبتالي إن شاء الله
+
+463
+00:34:05,360 --> 00:34:07,700
+هنطلع عليه بشكل منفصل بإذن الله. 
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ed1566c52283e2b04be0ed130a4ba837bcdce605
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU_postprocess.srt
@@ -0,0 +1,1852 @@
+1
+00:00:20,940 --> 00:00:23,780
+بسم الله الرحمن الرحيم نكمل اليوم ان شاء الله أخر
+
+2
+00:00:23,780 --> 00:00:29,180
+فيروس في المحاضرة وهذا الفيروس يعتبر من عائلة ال
+
+3
+00:00:29,180 --> 00:00:35,260
+retro viruses وهو الأخ الشقيق لل HIV لكن هناك بعض
+
+4
+00:00:35,260 --> 00:00:37,860
+التشابهات وبعض الاختلافات سنترقل ان شاء الله في
+
+5
+00:00:37,860 --> 00:00:41,260
+هذه المحاضرة وحنشوف الأمراض اللي بيسببها وكيفية
+
+6
+00:00:41,260 --> 00:00:48,550
+إحداثه للسلطان في البشروالقالية المستخدمة من خلال
+
+7
+00:00:48,550 --> 00:00:51,810
+هذا البرنامج تختلف عن الانكو فيروس المعروفين اللي
+
+8
+00:00:51,810 --> 00:00:55,610
+هم بسببه السرطانة الصورة اللي جدانا بتوضح ان في
+
+9
+00:00:55,610 --> 00:01:00,530
+انديtwo copies of the same genome وهذا ينطبق على
+
+10
+00:01:00,530 --> 00:01:04,190
+ما قلنا سابقا بأن ال retrovirus يستحتوي على كلمة
+
+11
+00:01:04,190 --> 00:01:07,650
+diploid كلمة diploid يعني two copies of the same
+
+12
+00:01:07,650 --> 00:01:12,250
+gene مش قطعتين مختلفتين زي قطعة مختلفة زي ال
+
+13
+00:01:12,250 --> 00:01:16,110
+influenza أو زي ال rheovirus اللي هو ال retrovirus
+
+14
+00:01:16,110 --> 00:01:21,210
+لأ هم قطعتين نسختين من معنى أخر إنهم بيشبهوا بعض
+
+15
+00:01:26,120 --> 00:01:28,940
+هناك في ال retroviruses only two medically
+
+16
+00:01:28,940 --> 00:01:32,060
+important viruses اللي هم ال human T cell
+
+17
+00:01:32,060 --> 00:01:34,620
+lymphotropic virus اللي احنا قايد الدراسة اليوم
+
+18
+00:01:34,620 --> 00:01:38,740
+والثاني هو ال human immunodeficiency virus او ال
+
+19
+00:01:38,740 --> 00:01:43,000
+HIV الأمراض اللي بسببها هذا الفيروس اللي احنا بصدر
+
+20
+00:01:43,000 --> 00:01:46,420
+دراسته اليوم هم مرضين واحد هو عبارة عن cancer
+
+21
+00:01:46,420 --> 00:01:50,500
+ويسمى adult T cell leukemia او adult T cell
+
+22
+00:01:50,500 --> 00:01:55,100
+lymphoma لأنه بصيب ال lymphocytesو بالتحديد الـ
+
+23
+00:01:55,100 --> 00:02:00,480
+CD4 Plus Lymphocyte بذكركم بمين برضه؟ بالـ HIV،
+
+24
+00:02:00,480 --> 00:02:04,300
+الـ HIV برضه بصيب هذا النوع منها من الخلاياإن
+
+25
+00:02:04,300 --> 00:02:07,140
+المرض التاني عبارة عن neurological disease
+
+26
+00:02:07,140 --> 00:02:11,240
+neurological disease يعني مرض له علاقة بالأعصاب أو
+
+27
+00:02:11,240 --> 00:02:16,760
+بيسموه myelopathy او HTLV associated myelopathy و
+
+28
+00:02:16,760 --> 00:02:22,040
+بيختصروه HAN H A N كمان مرة HTLV associated
+
+29
+00:02:22,040 --> 00:02:25,940
+myelopathy إيه الأسماء التانية مش كتير معنين فيها
+
+30
+00:02:25,940 --> 00:02:31,400
+هناك نسخة أخرى من البيروت بيسموها HTLV-2 ويعتقد
+
+31
+00:02:31,400 --> 00:02:37,100
+إنها بتسبب نفس الأمراض لكنربطها بين الفيروس اللى
+
+32
+00:02:37,100 --> 00:02:42,100
+هو نسخة نين htlv2 وما بين المرضين اللى ذكرناهم قبل
+
+33
+00:02:42,100 --> 00:02:46,520
+قليل ال association مش بنفس قوة ال association ما
+
+34
+00:02:46,520 --> 00:02:51,860
+بين htlv1 و هدين المرضين بمعنى أخر ماعناش دلائل
+
+35
+00:02:51,860 --> 00:02:58,260
+بحجم الدلائل اللى بتتهم أو بتورط الأول في هدول
+
+36
+00:02:58,260 --> 00:02:58,760
+المرضين
+
+37
+00:03:01,490 --> 00:03:09,190
+الـHTLV والـHIV هما أشخاص مهمة في مصادر التجارة
+
+38
+00:03:09,190 --> 00:03:14,950
+كلاهما انفلوب واضح أننا نتكلم عن RNA انفلوب
+
+39
+00:03:14,950 --> 00:03:20,070
+فيروسات مع ترانسكربتيز يعني لديهم الانزيم الاسم
+
+40
+00:03:20,070 --> 00:03:22,170
+reverse transcriptase على الرغم من أنهم خدوا
+
+41
+00:03:22,170 --> 00:03:27,270
+بالكوا positive polarity RNA إذا لماذا بيلزم في
+
+42
+00:03:27,270 --> 00:03:32,040
+هذه الحالة reverse transcriptase؟طب ليش بيلزم
+
+43
+00:03:32,040 --> 00:03:36,060
+يتحول ل DNA؟
+
+44
+00:03:36,060 --> 00:03:40,400
+جزء من الcycle تبعت و ليش؟ بيعمل integration لأن
+
+45
+00:03:40,400 --> 00:03:42,560
+انا ساطر ان انا اعمل integration بRNA لازم اعمل
+
+46
+00:03:42,560 --> 00:03:46,200
+integration بمين؟ ب DNA إذا بيلزموا في هذه الحالة
+
+47
+00:03:46,200 --> 00:03:49,360
+اللي هو من عنده reverse transcriptase كلا هما
+
+48
+00:03:49,360 --> 00:03:54,220
+بيحتوي على reverse transcriptase both have
+
+49
+00:03:54,220 --> 00:03:57,520
+deployed كنا deployed يعني two copies of the same
+
+50
+00:03:57,520 --> 00:04:06,830
+genomeالان نجي للفرقات الفرق الاول hiv kills T
+
+51
+00:04:06,830 --> 00:04:13,690
+cells بينما ال htlv immortalize ايش معناه موت ايش
+
+52
+00:04:13,690 --> 00:04:18,730
+عكسها خلود مظبوط الموت عكسه خلود ال hiv بيموت
+
+53
+00:04:18,730 --> 00:04:23,020
+الخلية بينماهذا الفيروس بيعملها transformation إلى
+
+54
+00:04:23,020 --> 00:04:25,740
+cancer cell وانت بتعرف ان ال cancer cell is
+
+55
+00:04:25,740 --> 00:04:29,460
+immortal cell وبالتالي فيه فرق بين التانين لكن
+
+56
+00:04:29,460 --> 00:04:33,660
+خدوا بالكم سواء كانت ماتت ولا immortal ال function
+
+57
+00:04:33,660 --> 00:04:36,920
+تبعتها موجودة مش موجودة ال function وبالتالي
+
+58
+00:04:36,920 --> 00:04:42,080
+التانين هيولدوا sort of lower immunity يعني مش هم
+
+59
+00:04:42,080 --> 00:04:46,080
+بنقول immunodeficiency syndrome ال HIV وايضا كمان
+
+60
+00:04:46,080 --> 00:04:49,700
+هذا بيؤدي إلى نوع من انخفاض في جهاز المنعم
+
+61
+00:04:56,270 --> 00:05:00,130
+في فرصة أخرى متعرفة على الـ HIV من خلال هذا
+
+62
+00:05:00,130 --> 00:05:03,470
+الفيروس لأنه بتكلم على نفس ال structure تقريبا بين
+
+63
+00:05:03,470 --> 00:05:07,740
+الاتنين فمثلاكل الريتروفيروس بيحتوى على three
+
+64
+00:05:07,740 --> 00:05:11,520
+structural genes مشهورين جدا اسمهم جاج و بول و ان
+
+65
+00:05:11,520 --> 00:05:16,960
+فادولة اسمهم structural genes our virus contains
+
+66
+00:05:16,960 --> 00:05:21,340
+two functional genes او regulatory genes اسمهم TAX
+
+67
+00:05:21,340 --> 00:05:26,760
+and REX لحظة ال TAX and REX هتلاقي انه يلهم شبه
+
+68
+00:05:26,760 --> 00:05:31,660
+كبير بينهم وبين اللي هم ال functional او ال
+
+69
+00:05:31,660 --> 00:05:36,700
+regulatory genes تبعون ال HIV كلمة شبهفي الـ size
+
+70
+00:05:36,700 --> 00:05:40,600
+وفي ال structure وفي ال function طب إيه ده بيشبهوا
+
+71
+00:05:40,600 --> 00:05:44,140
+بعض في ال structure وبيشبهوا بعض في ال size وفي ال
+
+72
+00:05:44,140 --> 00:05:48,040
+function؟ ليش بيختلفوا عن بعض؟ ليش بيختلفوا عن
+
+73
+00:05:48,040 --> 00:05:51,600
+بعض؟ لو هم كلمة بيشبهوا مش identical يعني لو
+
+74
+00:05:51,600 --> 00:05:55,680
+identical كانوا نفس الاسم بس مش identical زي مثلا
+
+75
+00:05:55,680 --> 00:05:59,020
+ال gag و ال pull و ال inf identical فاطلهم نفس ال
+
+76
+00:05:59,020 --> 00:06:03,620
+ايه؟ نفس الاسم لكن هدولة اختلفوا بيدكركوا بس بنقطة
+
+77
+00:06:03,620 --> 00:06:12,100
+مهمة جداإنه قد نتشابه في ال size قد نتشابه في ال
+
+78
+00:06:12,100 --> 00:06:16,440
+function زي ما احنا الآن هنا طلاب هاي وظيفتنا طلاب
+
+79
+00:06:16,440 --> 00:06:21,120
+كنا بنمتلك عقل العقل ليهاش وظيفته يفكر ويدرس ويديب
+
+80
+00:06:21,120 --> 00:06:25,440
+على بقى في الامتحان تمام؟ هل الأداء اللي موجود في
+
+81
+00:06:25,440 --> 00:06:30,180
+الفصل للجميع الجميع بيشترك بيد الخاصية لكن هل
+
+82
+00:06:30,180 --> 00:06:35,350
+الأداء تبع الوظيفة بنفس الكفاءة؟أذكركم بمثال حقيقي
+
+83
+00:06:35,350 --> 00:06:41,550
+درسناه لما درسنا ال papilloma virus كنا في ال
+
+84
+00:06:41,550 --> 00:06:44,710
+papilloma virus يا بنات في بعض السلالات بعض
+
+85
+00:06:44,710 --> 00:06:48,830
+السلالات تعمل cancer cervical cancer وبعض السلالات
+
+86
+00:06:48,830 --> 00:06:52,290
+ماملش لما جينا اتطلعنا على الجينات المسؤولة رجاله
+
+87
+00:06:52,290 --> 00:06:57,790
+مائية ستة و اية سبعةE6 وE7 الموجودين في كل ال
+
+88
+00:06:57,790 --> 00:07:02,130
+Papilloma Viruses ايش معنى 16 و18 هم اللي عملوا
+
+89
+00:07:02,130 --> 00:07:05,630
+cancer و الباقيين اللي عملوش cancer مع انه كلهم
+
+90
+00:07:05,630 --> 00:07:10,230
+بيحتوي على E6 وE7 فسرناكوا في حينها قلنالكوا ان
+
+91
+00:07:10,230 --> 00:07:13,470
+البروتينات اللي خارجة من ال E6 وE7 من هدول
+
+92
+00:07:13,470 --> 00:07:17,290
+السلالتين اكتر قدرة على الارتباط بال
+
+93
+00:07:17,290 --> 00:07:21,030
+Retinoplastoma و ال B53 proteins
+
+94
+00:07:22,470 --> 00:07:29,010
+وبالتالي هي ليست الوظيفة وانما مستوى أداء الوظيفة
+
+95
+00:07:29,010 --> 00:07:32,670
+هو اللي عمل فرق، كمان مرة ليست الوظيفة بحد ذاتها
+
+96
+00:07:32,670 --> 00:07:35,930
+وانما مستوى أداء هذه الوظيفة
+
+97
+00:07:38,530 --> 00:07:43,230
+طبعا هذا الكلام احنا بنأكد عليه عشان انه نفسر كثير
+
+98
+00:07:43,230 --> 00:07:48,850
+من الأشياء اللي احنا قد يعني تشترك فيها الفيروسات
+
+99
+00:07:48,850 --> 00:07:52,910
+لكن ال outcomes او النتائج المخرجات تبعتها تكون
+
+100
+00:07:52,910 --> 00:07:53,710
+مختلفة
+
+101
+00:07:56,260 --> 00:08:00,920
+طبعا فينا كمان شغل مهم مثلها انا انه بيقولنا انه
+
+102
+00:08:00,920 --> 00:08:06,700
+اختلاف بسيط في ال amino acid sequence ادى الاختلاف
+
+103
+00:08:06,700 --> 00:08:12,980
+في ال antigenicity بين ال HIV و ال HTLV
+
+104
+00:08:13,690 --> 00:08:19,310
+ومثال تاني بتأكيد على المثال الـ B24 is a major
+
+105
+00:08:19,310 --> 00:08:24,490
+nucleocapsid protein in both HTLV and HIV but they
+
+106
+00:08:24,490 --> 00:08:27,990
+differ antigenically لأنه جدالكو اختلاف بسيط في ال
+
+107
+00:08:27,990 --> 00:08:34,230
+amino acid sequenceالـ Varian لـ both HTLV and HIV
+
+108
+00:08:34,230 --> 00:08:36,710
+Contains a reverse transcriptase وحكينا على كلام
+
+109
+00:08:36,710 --> 00:08:40,510
+لكن كمان بتحتوي Integrase و Protease ليش
+
+110
+00:08:40,510 --> 00:08:43,310
+Integrase؟ لأن احنا بدنا نعمل integration للجينوم
+
+111
+00:08:43,310 --> 00:08:47,590
+تبع الفيروس إلى داخل اللي هو ال host cell طب ليش
+
+112
+00:08:47,590 --> 00:08:51,910
+بدنا Protease؟ لأنه إذا فاكرين لما درسنا لبروتين
+
+113
+00:08:51,910 --> 00:08:56,170
+في ال virus structure قلنا هناك بعض الفيروسات لا
+
+114
+00:08:56,170 --> 00:09:00,810
+تستطيعلتستطيع أن تنتج functional protein، تنتجها
+
+115
+00:09:00,810 --> 00:09:05,730
+اسمها precursor polypeptide، فتحتاج البروتييز to
+
+116
+00:09:05,730 --> 00:09:09,910
+cut this precursor into functional proteins أو
+
+117
+00:09:09,910 --> 00:09:11,170
+polypeptide
+
+118
+00:09:13,250 --> 00:09:17,450
+الـ Envelope Protein في الـHTLV بتحتوي على GP46 و
+
+119
+00:09:17,450 --> 00:09:23,430
+GP21 بينما في الـHIV بتحتوي على GP120 و GP41 طبعا
+
+120
+00:09:23,430 --> 00:09:26,050
+كل كلمة بتحدث عن ان الـ Envelope Protein في
+
+121
+00:09:26,050 --> 00:09:33,730
+الـHTLV هم GP46 و GP21 هدولة مقابلهمفي الـHIV كان
+
+122
+00:09:33,730 --> 00:09:38,390
+فينا الـGP120 والـGP41 طبعا هدول الـGlycoproteins
+
+123
+00:09:38,390 --> 00:09:42,570
+هم عبارة عن spikes على ال envelopes و هم المسؤولين
+
+124
+00:09:42,570 --> 00:09:46,750
+عن الارتباط بالـ host cell اللي هي الـCD4 في هذه
+
+125
+00:09:46,750 --> 00:09:54,610
+الحالة لان نجي لاريجولاتوريا البروتينز كنا فيه TAX
+
+126
+00:09:54,610 --> 00:09:59,420
+و فيه REX مظبوطومقابلهم في الـHIV في حاسمة TAT
+
+127
+00:09:59,420 --> 00:10:03,520
+وحاسمة REV لحظة انهم بيشتركوا بالأول حرفين
+
+128
+00:10:03,520 --> 00:10:10,220
+وبيختلفوا بالحرف التالت تاكس تات ريكس ريف تمام؟
+
+129
+00:10:10,220 --> 00:10:14,320
+الآن الـ Tax Protein هو الأهم على الإطلاق وحنشوف
+
+130
+00:10:14,320 --> 00:10:19,540
+الآن جداش مهمته في إحداث الكانسر مثلا بقولنا Tax
+
+131
+00:10:19,540 --> 00:10:22,560
+Protein is a transcriptional activator
+
+132
+00:10:24,810 --> 00:10:28,270
+بدى قبل ما أبدأ أشرح عنه بنتكلم على موضوع اللي هو
+
+133
+00:10:28,270 --> 00:10:32,910
+ال viruses و إحداثها لانكوجين لل human هذا هو
+
+134
+00:10:32,910 --> 00:10:36,430
+المعتاد اللي احنا بنعرفه في الانكو viruses هذا ال
+
+135
+00:10:36,430 --> 00:10:41,190
+virus لا بيعمل هيك لا بيحمل انكوجين ولا بيعمل
+
+136
+00:10:41,190 --> 00:10:46,610
+insertion لانكو جنب انكوجين طبعا كيف بيشتغل؟ كل
+
+137
+00:10:46,610 --> 00:10:49,690
+اعتماد البناء العالمين على ال tax protein اللي هو
+
+138
+00:10:49,690 --> 00:10:55,880
+transcriptional activator كيف بيشتغل؟الـ
+
+139
+00:10:55,880 --> 00:10:58,940
+activation of transcription of both cellular and
+
+140
+00:10:58,940 --> 00:11:02,140
+viral mRNA synthesized by a tax protein that
+
+141
+00:11:02,140 --> 00:11:06,500
+initiate oncogenesis يبجى هو بيجي بينهم و بيمروا
+
+142
+00:11:06,500 --> 00:11:10,220
+على كل الجينات سواء كانت فيروسية أو أدمية و
+
+143
+00:11:10,220 --> 00:11:14,560
+بيعملها transcription بيعمل تنشيط لمين؟ للـ
+
+144
+00:11:14,560 --> 00:11:19,420
+transcription يبجى هتطلع بروتينات عديدة من ضمن هذه
+
+145
+00:11:19,420 --> 00:11:24,140
+البروتينات ابنات الـ Interleukin-2الـ Interlochen
+
+146
+00:11:24,140 --> 00:11:29,120
+II قائد مهم جدا في جهاز المناعة لكن لابد أن يكون
+
+147
+00:11:29,120 --> 00:11:35,540
+قائد واحدبعدد محدود من الأوامر، تمام؟ لو صار عندنا
+
+148
+00:11:35,540 --> 00:11:40,580
+عشرة، عشرة قادة، وكل واحد بيعطي أوامر، تمام؟ أكيد
+
+149
+00:11:40,580 --> 00:11:45,300
+حيصير في عندنا خلل، بالإضافة إلى العاصفة اللي نتجت
+
+150
+00:11:45,300 --> 00:11:48,700
+عن كل البروتينات الجديدة اللي طلعت، اللي المفروض
+
+151
+00:11:48,700 --> 00:11:52,740
+ماتطلعش، طلعت لأنه في activator اللي موجود في هذا
+
+152
+00:11:52,740 --> 00:11:57,520
+الفيروس، فبصير في عندي hyper activity في الخلية
+
+153
+00:11:58,130 --> 00:12:01,470
+وانتوا عارفين ان ال cancer cell uncontrolled
+
+154
+00:12:01,470 --> 00:12:06,630
+growth غير مسيطر عليه وهذا اللي بيحدث بالفعل في
+
+155
+00:12:06,630 --> 00:12:10,470
+الخليج، مين اللي بيساهم فيه؟ اللي هو ال tax
+
+156
+00:12:10,470 --> 00:12:13,570
+protein اللي هو قابل عن ال transcriptional
+
+157
+00:12:13,570 --> 00:12:18,700
+activator proteinالان في كامة نقطة مهمة لازم
+
+158
+00:12:18,700 --> 00:12:21,920
+نعرفها ان هذا الفيروس is much more stable او
+
+159
+00:12:21,920 --> 00:12:26,900
+الجينات تبعته is much more stable than HIV هدى ال
+
+160
+00:12:26,900 --> 00:12:29,940
+stability فى صالح مين؟ فى صالح ال HIV ولا فى صالح
+
+161
+00:12:29,940 --> 00:12:30,660
+هذا الفيروس؟
+
+162
+00:12:33,300 --> 00:12:37,220
+أكيد في صالح ال HIV ال instability في صالح الفيروس
+
+163
+00:12:37,220 --> 00:12:42,100
+دايما ليش لأنه دايما بيغير من من جيناته يبقى بيغير
+
+164
+00:12:42,100 --> 00:12:46,020
+من انتجناته لما بقول ان هذا الفيروس stable او مش
+
+165
+00:12:46,020 --> 00:12:49,260
+stable بيكونوا يعرفوا انه لها consequence ال
+
+166
+00:12:49,260 --> 00:12:54,160
+stable يعني زي ال smallpox stable الفيروس مالوش
+
+167
+00:12:54,160 --> 00:12:57,900
+الغير كان ايه one single strain هذا له two strains
+
+168
+00:12:57,900 --> 00:13:03,590
+اذا عرفناهم اللي هم hdlv-1 و hdlv-2الصورة اللى
+
+169
+00:13:03,590 --> 00:13:07,950
+قدامنا اتطلع عليها منيح لو انا مش مكتوب عليها كلام
+
+170
+00:13:07,950 --> 00:13:11,550
+هذا الكلام مش مكتوب عليها كان بقول يمكن هذا hiv
+
+171
+00:13:11,550 --> 00:13:15,510
+لأنهم بيشبهوا بعض كتير هم ايش الفرق بينهم فاكرين
+
+172
+00:13:15,510 --> 00:13:22,650
+ال GP's GP 46 و GP وينه 21 تمام هدول اللى بيبقوا
+
+173
+00:13:22,650 --> 00:13:26,830
+معاهم بيرتبطوا ب ال receptors اللى موجودة في ال
+
+174
+00:13:26,830 --> 00:13:33,330
+CD4 plus cellsكيف ينتقل هذا الفيروس؟ احنا بنعرف ان
+
+175
+00:13:33,330 --> 00:13:35,590
+الـHIV بينتقل عن طريق الـGens، بينتقل عن طريق
+
+176
+00:13:35,590 --> 00:13:38,910
+الدم، بينتقل عن طريق اللي هو ال .. برضه ال ..
+
+177
+00:13:38,910 --> 00:13:42,130
+اعتقد انه نفس ال .. نفس الفكرة انتقال، لكن
+
+178
+00:13:42,130 --> 00:13:45,890
+بالاضافة لذلك في عندي اللي هو الـbreast feeding من
+
+179
+00:13:45,890 --> 00:13:49,910
+رضاعة الطبيعي Intravenous drug use, sexual contact
+
+180
+00:13:49,910 --> 00:13:55,890
+or breast feeding هناك بعض اثباتات غير مؤكدة بإنه
+
+181
+00:13:55,890 --> 00:13:59,030
+ممكن انتقل الـtrans placental من الأم إلى الجنين
+
+182
+00:14:00,890 --> 00:14:03,950
+الترانسبيشن عبر البلد مدى ما بينتقل عن طريق ال
+
+183
+00:14:03,950 --> 00:14:06,850
+drug .. drug intravenous drug use بجهة أكيد بنتقل
+
+184
+00:14:06,850 --> 00:14:10,090
+عن طريق ال blood transfusion لكن في بنوك الدم في
+
+185
+00:14:10,090 --> 00:14:12,470
+تلك البلدان اللي فيها هذا الفيروس المنتشر بشكل
+
+186
+00:14:12,470 --> 00:14:16,710
+كبير أصبح جزء من ال screening لل blood bags أن
+
+187
+00:14:16,710 --> 00:14:22,120
+نفحص عن ال antibodies تبع ال HTLVفأي blood bag
+
+188
+00:14:22,120 --> 00:14:26,240
+فحصة positive لهذا الفيروس it will be discarded
+
+189
+00:14:26,240 --> 00:14:31,000
+وبتالي عدد حالة الانتقال عبر ال blood transfusion
+
+190
+00:14:31,000 --> 00:14:35,740
+لهذا المرة تقريبا zero Transmission is thought to
+
+191
+00:14:35,740 --> 00:14:39,500
+occur هذه نقطة كتير برضه مهمة يعني برضه غريبة ان
+
+192
+00:14:39,500 --> 00:14:44,220
+ال virus بينتقلش بشكل حر يا بنات بينتقل عبر خلية
+
+193
+00:14:44,220 --> 00:14:49,340
+مصابة إذا يجب أن ينتقل من إنسان إلى إنسان تمام
+
+194
+00:14:49,340 --> 00:14:54,280
+لإنفساعة مصابةLymphocyte مصابر مش الفيروس ال free
+
+195
+00:14:54,280 --> 00:15:01,040
+وانما ال lymphocyte مثلا بقولنا انه في المثال اللي
+
+196
+00:15:01,040 --> 00:15:04,660
+اعتقد اللي وراه على طول ال whole blood مش ال
+
+197
+00:15:04,660 --> 00:15:09,300
+plasma اللي بتنجل الفيروسكمان الـ infected
+
+198
+00:15:09,300 --> 00:15:13,420
+lymphocyte في السائل المنوي هي المسئولة عن نقل
+
+199
+00:15:13,420 --> 00:15:18,500
+الفيروس عبر اللي هو ال sexual contact، إذا خلايا
+
+200
+00:15:18,500 --> 00:15:23,940
+مصابة و ليست فيروسات حرة هي المسئولة عن الانتقال
+
+201
+00:15:24,980 --> 00:15:28,140
+هناك مناطق عالميا معروفة ان فيها نسبة عالية من هذا
+
+202
+00:15:28,140 --> 00:15:30,660
+الفيروس زي الـ Caribbean Region في Southern
+
+203
+00:15:30,660 --> 00:15:33,800
+Florida و Eastern South America في Western Africa
+
+204
+00:15:33,800 --> 00:15:37,880
+و Southern Japan لكن على الرغم من ان في هذه
+
+205
+00:15:37,880 --> 00:15:41,640
+البلدان أو هذه المناطق يعني قد تصل نسبة الإصابة
+
+206
+00:15:41,640 --> 00:15:47,880
+إلى عشرين بالمائة من السكانإلا إنه مش لازم نغفل إن
+
+207
+00:15:47,880 --> 00:15:51,420
+هؤلاء الناس في تلك المناطق لن يبقوا في تلك
+
+208
+00:15:51,420 --> 00:15:54,620
+المناطق، يعني هم بيتحركوا، بيسافروا، بيهاجروا،
+
+209
+00:15:54,620 --> 00:15:58,180
+ممكن يقضوا أو قط، أوطل هنا أو هناك، وبالتالي هم
+
+210
+00:15:58,180 --> 00:16:03,020
+ناقلين للفيروس، يعني نقدر نقول إن الفيروس should
+
+211
+00:16:03,020 --> 00:16:09,860
+be expected all over the worldولا نص المصابين اللي
+
+212
+00:16:09,860 --> 00:16:12,220
+كانوا في ولاية المتحدة، مش نص ولاية المتحدة، نص
+
+213
+00:16:12,220 --> 00:16:16,020
+المصابين من ولاية المتحدة كانوا مصابين بالنسخة
+
+214
+00:16:16,020 --> 00:16:22,500
+التانية اللي هي الـHTLV2 واللي غالبا تنتقل عبر
+
+215
+00:16:22,500 --> 00:16:25,820
+الـIntravenous Drug Use، يعني تبعهم المخدرات هم
+
+216
+00:16:25,820 --> 00:16:29,560
+اللي بيصابوا بهذا الفيروس
+
+217
+00:16:32,280 --> 00:16:36,760
+أحنا ذكرنا في المقدمة أنه في مرضين مهمين ومنفصلين
+
+218
+00:16:36,760 --> 00:16:41,360
+تماما بسببهم هذا الفيروس اللي هم الـ other T cell
+
+219
+00:16:41,360 --> 00:16:46,860
+leukemia أو ATL والـHTLV infection للـ CD4 T
+
+220
+00:16:46,860 --> 00:16:49,500
+lymphocyte بيعمل malignant transformation يعني
+
+221
+00:16:49,500 --> 00:16:54,700
+cancer يعني cancer والـHTLV في هذه الحالة latent
+
+222
+00:16:54,700 --> 00:16:58,420
+within the malignant cells هذا اللي .. هذا ال ..
+
+223
+00:16:58,420 --> 00:17:01,640
+ال .. ال .. ال .. ال ..اللي بيخلّي الكلام اللي
+
+224
+00:17:01,640 --> 00:17:05,300
+احنا حكيناه قبل قليل يكون له معنى انه الانتقال عبر
+
+225
+00:17:05,300 --> 00:17:09,380
+الـ lymphocytes و ليس عبر اللي هو قولنا ال .. ال
+
+226
+00:17:09,380 --> 00:17:13,080
+.. نعم لأن
+
+227
+00:17:13,080 --> 00:17:16,440
+الـHTLV is typically not produced by the malignant
+
+228
+00:17:16,440 --> 00:17:20,180
+cell إذا الخلية صارت malignant، غالباً الفيروس ما
+
+229
+00:17:20,180 --> 00:17:24,680
+.. يعني مابيطلعش منها، بيظل موجود جوا، ليش؟ لأنه
+
+230
+00:17:24,680 --> 00:17:31,310
+هي لما بتتكاثر، هوالـ Provirus بتكثر مع هذه الخلية
+
+231
+00:17:31,310 --> 00:17:35,530
+الشكل
+
+232
+00:17:35,530 --> 00:17:38,310
+التاني من المعروف اللي قلنا سميناه ham او HTLV
+
+233
+00:17:38,310 --> 00:17:41,670
+-associated myelopathy الاحتلال العصبي المصاحب
+
+234
+00:17:41,670 --> 00:17:45,750
+لفيروس الـ HTLV وقلنا له أسماء أخرى tropical
+
+235
+00:17:45,750 --> 00:17:49,050
+spastic paraparesis paraparesis معناها ارتخاء
+
+236
+00:17:49,050 --> 00:17:53,810
+عضلات او شلال وspastic معناها انقباضي او chronic
+
+237
+00:17:54,780 --> 00:17:58,560
+progressive myelopathy وكلمة chronic يعني مزمن
+
+238
+00:17:58,560 --> 00:18:03,160
+يعني طويل الأماد progressive بيصيب الإنسان في لحظة
+
+239
+00:18:03,160 --> 00:18:07,700
+معينة باعتلال بسيط وبيتطور هذا الاعتلال وبيزداد مع
+
+240
+00:18:07,700 --> 00:18:13,050
+أيه مع الزمن لكن على فترة طويلةكمان الهام عبارة عن
+
+241
+00:18:13,050 --> 00:18:17,170
+demyelinating disease لكل من الدماغ و ال spinal
+
+242
+00:18:17,170 --> 00:18:22,590
+cord و يؤثر أكثر على ال motor neurons و لما يؤثر
+
+243
+00:18:22,590 --> 00:18:26,510
+على ال motor neurons اللي هي الخلايا العصبية
+
+244
+00:18:26,510 --> 00:18:31,530
+الحركية أكيد برضه هيؤثر على الشلب أو يعمل الشلب
+
+245
+00:18:31,530 --> 00:18:42,670
+الآن بدنا نفهم النظرية اللي بتفسر حدوث الهامو هي
+
+246
+00:18:42,670 --> 00:18:47,870
+تتنافع مع ممكن كلام ذكرناه سابقا فهنحاول نوفق بين
+
+247
+00:18:47,870 --> 00:18:53,890
+المعناين بطريقة ما ham is caused by an autoimmune
+
+248
+00:18:53,890 --> 00:18:57,470
+cross reaction autoimmune cross reaction يعني
+
+249
+00:18:57,470 --> 00:19:03,550
+المفروض ان ال antibodies الموجهة للفيروس ماترتبتش
+
+250
+00:19:03,550 --> 00:19:08,050
+مع مين؟ مع خلائنا لكن كلمة cross reaction معناها
+
+251
+00:19:08,050 --> 00:19:11,580
+الحاجة انه صار في ارتباطin which the immune
+
+252
+00:19:11,580 --> 00:19:16,980
+response against HTLV damages the neuron or، هذا
+
+253
+00:19:16,980 --> 00:19:21,740
+احتمال تاني، by cytotoxic T-cells that kills HTLV
+
+254
+00:19:21,740 --> 00:19:25,060
+infected in neurons احنا بنعرف انه الجهاز العصبي
+
+255
+00:19:25,060 --> 00:19:31,210
+في الإنسان من الأماكن المحمية من جهاز المناعةويمكن
+
+256
+00:19:31,210 --> 00:19:33,990
+ذكرنا هذا الكلام في نقاش سابق ان it is protected
+
+257
+00:19:33,990 --> 00:19:37,290
+لأن اي بيروس بدي يصلي هنا الخلايا هذه و يصلي ال
+
+258
+00:19:37,290 --> 00:19:42,110
+toxic T cell تيجي تدمره اذا دمرته معناه الحكي انه
+
+259
+00:19:42,110 --> 00:19:46,330
+فينا خلل لان الخلية العصبية اللي بتموت فش غيرها،
+
+260
+00:19:46,330 --> 00:19:52,850
+مظبوط؟ فهو من ال privilege ساعت في الجسم
+
+261
+00:19:53,630 --> 00:19:57,770
+لكن لما ييجي antibody cross-reacting ويرتبط فيه
+
+262
+00:19:57,770 --> 00:20:03,650
+الارتباط بيعمل marking التليفوسيات تفهمش كتير إلا
+
+263
+00:20:03,650 --> 00:20:08,130
+إشارات معينةفال mark هذه ان هذا ال antibody مرتبط
+
+264
+00:20:08,130 --> 00:20:11,510
+بهذه الخلية يبقى هذه mark او اشارة لل T cell تعيط
+
+265
+00:20:11,510 --> 00:20:15,750
+T cell اقتل هذه الخلية فهذا قد يكون السبب ان في ال
+
+266
+00:20:15,750 --> 00:20:19,450
+cross reaction ذهبت ال antibodies الى ال neurons
+
+267
+00:20:19,450 --> 00:20:24,950
+وبالتالي اعطت wrong information ل ال T cells اللي
+
+268
+00:20:24,950 --> 00:20:26,330
+قتلت هذه ال neurons
+
+269
+00:20:29,980 --> 00:20:33,940
+لـ Clinical findings الـ ATL is characterized by
+
+270
+00:20:33,940 --> 00:20:37,660
+lymphadenopathy, hepatospinomegaly, lytic bone,
+
+271
+00:20:38,280 --> 00:20:42,880
+bone lesions, and skin lesions كل هذه الليشين اللي
+
+272
+00:20:42,880 --> 00:20:46,240
+هملك عنها و الهيباتوميجالي و الاسبينوميجالي ناتجة
+
+273
+00:20:46,240 --> 00:20:51,700
+عن تكاثر اللي هو الـ T cell infiltrating these
+
+274
+00:20:51,700 --> 00:20:56,360
+organs عشان infiltrating تتسلل إلى هذه الأعضاء
+
+275
+00:20:58,570 --> 00:21:04,090
+في الدم الماريجنان تي سيل لها شكل حلو كتير بيسموه
+
+276
+00:21:04,090 --> 00:21:08,070
+flower-shaped nucleus هنشوف صورة كمان شوية له صورة
+
+277
+00:21:08,070 --> 00:21:13,530
+جميلة لمرض خبيث hypercalcemia due to increased
+
+278
+00:21:13,530 --> 00:21:15,850
+osteoclastic activity شوفتوا قبل شوية احنا اتكلمنا
+
+279
+00:21:15,850 --> 00:21:20,070
+عن مين؟ عن lytic bone صح؟ فالـ lytic bone يعني فيه
+
+280
+00:21:20,070 --> 00:21:23,790
+ان خلايا عظمية بتتحلل خلايا عظمية بتتحلل ليش بيطلع
+
+281
+00:21:23,790 --> 00:21:27,230
+منها كالسيوم فبصير لنا نسبة كالسيوم عالية في هذا
+
+282
+00:21:27,230 --> 00:21:32,490
+الحالPatients with ATL often have reduced cell
+
+283
+00:21:32,490 --> 00:21:37,570
+-mediated immunity.عظم اني لما بنقول CD4 cells صار
+
+284
+00:21:37,570 --> 00:21:41,350
+فيها infection قل عددها السليمة يبقى معناه الحكي
+
+285
+00:21:41,350 --> 00:21:43,730
+ان هو بالفعل في عندي reduced cell-mediated
+
+286
+00:21:43,730 --> 00:21:48,630
+immunity وبالتالي هو الآن جريب لأخو ال HIV انه
+
+287
+00:21:48,630 --> 00:21:52,850
+بيخفض جهاز المنع طبعا لكن فعال اكتر اللي هو ال HIV
+
+288
+00:21:52,850 --> 00:21:56,270
+more effective in reducing immunity than this
+
+289
+00:21:56,270 --> 00:22:00,310
+diseaseطب يتصور عندنا سيل ميديا الـ immunity
+
+290
+00:22:00,310 --> 00:22:04,850
+depressed بصير عندي opportunistic infection with
+
+291
+00:22:04,850 --> 00:22:10,520
+fungi and other viruses ال clinical pictureof ham
+
+292
+00:22:10,520 --> 00:22:13,960
+include gait وكلمة gait معناها walking
+
+293
+00:22:13,960 --> 00:22:20,500
+disturbances يعني مشكلة في الحركة وهذا نتج عن ضعف
+
+294
+00:22:20,500 --> 00:22:26,900
+العضلات اللي بتصيب ال lower limbs اللي هي الأطراف
+
+295
+00:22:26,900 --> 00:22:33,830
+السفلية و أيضا يصحي ذلك low back painممكن يكون فيه
+
+296
+00:22:33,830 --> 00:22:39,030
+فقدان للسيطرة على التبول والتبرز في بعض الحالات
+
+297
+00:22:39,030 --> 00:22:44,850
+ايضا كما ذكرنا في السابق ان فقدان الخلايا الحركية
+
+298
+00:22:44,850 --> 00:22:50,250
+بيكون لصالح او فقدان الحركة اكتر من فقدان الاحساس
+
+299
+00:22:50,250 --> 00:22:53,810
+في هذه الحالة لانه تأثير اكتر على الموتور النيور
+
+300
+00:22:55,070 --> 00:22:58,130
+هذه الصورة اللى ذكرناها قبل قليل قلنالكوا ان ال
+
+301
+00:22:58,130 --> 00:23:03,570
+nucleus بتكون عاملة زى الزهرة تمام فصورة جميلة
+
+302
+00:23:03,570 --> 00:23:11,050
+لكنها لمرض خبيث لأن هذا cancerطبعا ال .. ال .. ال
+
+303
+00:23:11,050 --> 00:23:12,950
+.. الـ T cell flower shape nucleus can also be
+
+304
+00:23:12,950 --> 00:23:16,630
+found in the spinal fluid، magnetic resonance
+
+305
+00:23:16,630 --> 00:23:19,450
+imaging اللي هو ال MRI، بتسمع بال MRI؟ اللي هي
+
+306
+00:23:19,450 --> 00:23:23,190
+تصوير ال .. ال .. ال .. الرنين، تصوير الرنين،
+
+307
+00:23:23,190 --> 00:23:27,650
+ماعطيناش أي specific findings، يعني بنشوف ال .. أو
+
+308
+00:23:27,650 --> 00:23:30,410
+ال .. ال .. الطبيب اللي عشانها، بيشوف إن هو هذا
+
+309
+00:23:30,410 --> 00:23:34,450
+المريض normal في الغالبprogression of symptoms
+
+310
+00:23:34,450 --> 00:23:37,930
+occur slowly or over a period of years يعني في بطء
+
+311
+00:23:37,930 --> 00:23:42,750
+زي ما ذكرنا أو على مدار سنوات طويلة ham occur
+
+312
+00:23:42,750 --> 00:23:48,440
+primarily in women of middle ageمنتصف العمر، the
+
+313
+00:23:48,440 --> 00:23:51,900
+disease resemble multiple sclerosis، فيه فرق بين
+
+314
+00:23:51,900 --> 00:23:55,960
+multiple sclerosis وبين هذا ال disease، إنه هذاك
+
+315
+00:23:55,960 --> 00:23:59,300
+بيشفى، ال multiple sclerosis فيه remission، بينما
+
+316
+00:23:59,300 --> 00:24:03,240
+هذا المرض ما بيصير فيه أنه remission، غالبا التطور
+
+317
+00:24:03,240 --> 00:24:09,060
+بيكون إلى الأسوأATL و ham are relatively rare
+
+318
+00:24:09,060 --> 00:24:11,460
+disease فاكرين لما اقول ان اجاب شوية عشرين بالمية
+
+319
+00:24:11,460 --> 00:24:14,480
+في بعض المناطق؟ العشرين بالمية لا تعني ان كل
+
+320
+00:24:14,480 --> 00:24:19,980
+العشرين بالمية سيتحولوا اليه اللي هو ATL او ham،
+
+321
+00:24:19,980 --> 00:24:25,320
+نسبة ضئيلة من هؤلاء المرضى ممكن يطوروا ATL او ham
+
+322
+00:24:26,220 --> 00:24:29,040
+The vast majority of people infected with HTLV
+
+323
+00:24:29,040 --> 00:24:32,980
+develop asymptomatic infection, usually detected
+
+324
+00:24:32,980 --> 00:24:35,840
+by the presence of antibody. اصلا كيف انا افهم انه
+
+325
+00:24:35,840 --> 00:24:40,920
+20% من الناس من خلال الهو testing of blood donors
+
+326
+00:24:40,920 --> 00:24:44,680
+لما بيجينا blood donor احنا مش بنفحصه احنا لل HIV
+
+327
+00:24:44,680 --> 00:24:48,420
+مثلا في غزة هانا و لل Hepatitis B و لل Hepatitis C
+
+328
+00:24:48,420 --> 00:24:51,500
+وعرفش اذا كان بيفحصه لاشياء اخرى بس انا اعتقد ان
+
+329
+00:24:51,500 --> 00:24:54,930
+هاي الأمراض اللي بيفحصوها routinelyالأقل لو كان
+
+330
+00:24:54,930 --> 00:24:59,690
+عندنا HT ال human T cell نعم ال .. ال ..
+
+331
+00:24:59,690 --> 00:25:04,190
+الينفوسايت جنهة فيروس وكانت تستنج ابنين دي لما
+
+332
+00:25:04,190 --> 00:25:08,170
+نعرف جداش ال population اللي كان عندهم Antibody من
+
+333
+00:25:08,170 --> 00:25:12,470
+خلال ال blood testing لل blood donors و هذا الكلام
+
+334
+00:25:12,470 --> 00:25:16,630
+بيسويه في كتير في مدينة العالم انه بدل ما ياخدوا
+
+335
+00:25:16,630 --> 00:25:19,170
+عينات من .. و الناس عاديين بيروح على بنك .. على
+
+336
+00:25:19,170 --> 00:25:23,690
+بنك الدموبيقعدوا هناك بنك الدم الباحثين وبيدوروا
+
+337
+00:25:23,690 --> 00:25:26,870
+على ال prevalence of diseases من خلال ال blood
+
+338
+00:25:26,870 --> 00:25:30,070
+وانا اقول انهم معينة ممثل عالمين عن المجتمع اللي
+
+339
+00:25:30,070 --> 00:25:36,110
+هم موجودين فيه okay only a small subset of those
+
+340
+00:25:36,110 --> 00:25:39,590
+infected will develop either ATL or HAM إذا النسبة
+
+341
+00:25:39,590 --> 00:25:44,450
+ضئيلة من هؤلاء الذين يصابون قد يطوروا ATL أو HAM
+
+342
+00:25:45,820 --> 00:25:50,880
+الـ lab diagnosis لهذه المرضين ممكن نكشف عنهم من
+
+343
+00:25:50,880 --> 00:25:54,260
+خلال الـ ELISA test to detect antibodies in
+
+344
+00:25:54,260 --> 00:25:57,900
+patient serum، إذا فهي إمكانية لقياس الـ antibody
+
+345
+00:25:58,810 --> 00:26:02,270
+طبعا زي ما ال HIV ال western blood هو ال
+
+346
+00:26:02,270 --> 00:26:06,690
+confirmatory test ايضا هو هنا ال confirmatory test
+
+347
+00:26:06,690 --> 00:26:10,050
+انتوا عارفين إليزا في كثير من الفحوصات تعتبر
+
+348
+00:26:10,050 --> 00:26:14,170
+screening كده بدنا نعمل confirmation بدنا نعمل
+
+349
+00:26:14,170 --> 00:26:17,570
+western blood في هذا الحال is used to confirm a
+
+350
+00:26:17,570 --> 00:26:21,240
+positive ELISA resultإذاً الـ ELISA لو جالت
+
+351
+00:26:21,240 --> 00:26:23,520
+negative فهو negative، لكن لو positive، it should
+
+352
+00:26:23,520 --> 00:26:27,640
+be confirmed by Western blood عشان هي كبنات لازم
+
+353
+00:26:27,640 --> 00:26:32,020
+يكونوا عارفين في مستويات التقارير، التحاليل،
+
+354
+00:26:32,020 --> 00:26:38,090
+ماينفعش نستعجل و نعطي المرضى نتائجيعني في بعض ..
+
+355
+00:26:38,090 --> 00:26:42,790
+في حالة أذكرها جيدا طلعت عنها في أحد المختبرات و
+
+356
+00:26:42,790 --> 00:26:46,830
+أنا كنت أشعر أعمل في ذاك المختبر طلعت عنها VDRL أو
+
+357
+00:26:46,830 --> 00:26:49,890
+RBR بتاعة الـ syphilis طلعت positive لفتاة في
+
+358
+00:26:49,890 --> 00:26:53,670
+الثامن عشر من عمرهاكانوا مسافروا على كندا وفي
+
+359
+00:26:53,670 --> 00:26:58,450
+الإجراءات .. في إجراءات لازم نعمل testing ..
+
+360
+00:26:58,450 --> 00:27:01,750
+testing للأشخاص اللي جابوا ياخدوا ال visa لمجموعة
+
+361
+00:27:01,750 --> 00:27:05,390
+من الأعمار ومنها ال syphilis تمام؟ فطلع من دون أن
+
+362
+00:27:05,390 --> 00:27:10,260
+عن العائلة تبعتها كلها طلعت بوسترفلمّا جابولي
+
+363
+00:27:10,260 --> 00:27:13,860
+الأمضاء التقارير فبقولهم أنتوا عملتوا confirmation
+
+364
+00:27:13,860 --> 00:27:18,000
+جانوا لأ طب قلتله ماعرفينش يعني تعطي نتيجة لأنثى
+
+365
+00:27:18,000 --> 00:27:20,420
+في قطاع غزة أو تكون syphilis positive ماعرفينش
+
+366
+00:27:20,420 --> 00:27:24,160
+يعني يعني ماتروحش على البيت ممكن تقتل صح ولا مش صح
+
+367
+00:27:24,160 --> 00:27:27,560
+فأبقينا
+
+368
+00:27:27,560 --> 00:27:31,800
+نتيجة أخرنا ظهور نتيجة لعبارة عن ما عملنا
+
+369
+00:27:31,800 --> 00:27:34,420
+confirmatory test فقلتله الفحص negative فحص
+
+370
+00:27:34,420 --> 00:27:38,660
+negative في في دايما في في ال ..في ال screening
+
+371
+00:27:38,660 --> 00:27:44,360
+test بيكون فيها اسمها non specific results وإلا
+
+372
+00:27:44,360 --> 00:27:48,300
+كان ماضطراش نعمل confirmation إذا ال negative
+
+373
+00:27:48,300 --> 00:27:50,400
+negative بس ال positive لازم نعمله ايه
+
+374
+00:27:50,400 --> 00:27:54,100
+confirmation فنرجوا منكم الموقف اللي ذكرته هذا
+
+375
+00:27:54,100 --> 00:27:58,940
+ناخده على سبيل الإبرة و المواضع في التأني و
+
+376
+00:27:58,940 --> 00:28:03,940
+التفكير قبل إصدار بعض النتائج في تحليل الطبيب
+
+377
+00:28:08,410 --> 00:28:12,950
+Okay PCR assay can detect the presence of HTLV RNA
+
+378
+00:28:12,950 --> 00:28:17,150
+or DNA within infected cells يعني ممكن لو أخدنا ال
+
+379
+00:28:17,150 --> 00:28:20,350
+buffer coat layer من الدم تبقى المريض و أخدنا ال
+
+380
+00:28:20,350 --> 00:28:23,870
+white blood cell نعمل extraction لل DNA أو ال RNA
+
+381
+00:28:23,870 --> 00:28:27,950
+و نقدر نكشف عن اللي هو الفيروس ال test used to
+
+382
+00:28:27,950 --> 00:28:31,010
+screen the red blood contains only هذه المعلومة
+
+383
+00:28:31,010 --> 00:28:38,070
+منيها أنا بكشفعن ال blood bag باكشف عن antibodies
+
+384
+00:28:38,070 --> 00:28:44,130
+لمين؟ لل HTLV-1 طب و ال HTLV-2 طب ما هو بتاني
+
+385
+00:28:44,130 --> 00:28:48,850
+بيسبب نفس الأمراض قبل قليل وإن كان وإن كان الدلائل
+
+386
+00:28:48,850 --> 00:28:53,570
+مش مؤكدة إن هو اللي بيسبب لكن المعلم بفترض إن هو
+
+387
+00:28:53,570 --> 00:28:56,790
+اللي بيسبب وبتاني لازم نبحث عنه هبقول إن أنا
+
+388
+00:28:56,790 --> 00:29:01,210
+بستخدم antigen ل HTLV-1 لكن هذا ال antigen اللي
+
+389
+00:29:01,210 --> 00:29:06,690
+حصل حظنا كان cross react withاللي هو HTLV-2 فقد
+
+390
+00:29:06,690 --> 00:29:12,410
+اكشف انا HTLV-2 او HTLV-1 وانا مش عارف من هما لكن
+
+391
+00:29:12,410 --> 00:29:17,230
+positive لأي من هما لكن للأسف هذا الفحص ايضا في
+
+392
+00:29:17,230 --> 00:29:22,110
+بعض العيوب انه بيفقد بعض ال HTLV-2 اذا بعض الحالات
+
+393
+00:29:22,110 --> 00:29:27,530
+قد يفقدها اذا الفحص تبعنا هنا مش sensitive للتنين
+
+394
+00:29:27,530 --> 00:29:31,310
+وانما sensitive لمن لل HTLV-1 فقط
+
+395
+00:29:35,650 --> 00:29:39,850
+ال isolation لل HTLV in cell culture is not done و
+
+396
+00:29:39,850 --> 00:29:43,930
+السبب المفروض أنكم تكونوا فاهمته الآن لأنه
+
+397
+00:29:43,930 --> 00:29:47,790
+مابتكثرش تكاثر طبيعي في الخلايا و انما بيعمل
+
+398
+00:29:47,790 --> 00:29:52,320
+transformation بيعمل transformationATL is
+
+399
+00:29:52,320 --> 00:29:55,380
+diagnosed by finding malignant T-cells in the
+
+400
+00:29:55,380 --> 00:29:58,440
+lesions يعني لو شوفنا خلايا سلطانية في الـ lesions
+
+401
+00:29:58,440 --> 00:30:02,680
+الشكل اللي احنا شوفناه قبل قليل، هذا مميز إلينا
+
+402
+00:30:02,680 --> 00:30:05,280
+الـdiagnosis of HAM is supported by the presence
+
+403
+00:30:05,280 --> 00:30:08,760
+of HTLV antibodies in the spinal fluid يعني إذا
+
+404
+00:30:08,760 --> 00:30:13,380
+بناخد عينات من وين؟ من الـCSF أو finding HTLV
+
+405
+00:30:13,380 --> 00:30:17,430
+nucleic acid in cells in the spinal fluidأيش كيف
+
+406
+00:30:17,430 --> 00:30:22,950
+نجد الـ Nucleic Acid من خلال الـ PCR اللي حكينا
+
+407
+00:30:22,950 --> 00:30:28,710
+عنه قبل قليل ال treatment and prevention there is
+
+408
+00:30:28,710 --> 00:30:32,310
+no specific antiviral treatment of HTLV infection
+
+409
+00:30:32,310 --> 00:30:36,310
+and no antiviral drugs يعني لا إله vaccine ولا إله
+
+410
+00:30:36,310 --> 00:30:39,330
+antiviral
+
+411
+00:30:39,330 --> 00:30:43,610
+drug will cure latent infection by HTLV خاصة أنه
+
+412
+00:30:43,610 --> 00:30:45,750
+احنا بنتكلم عن latent infection و هذا الكلام
+
+413
+00:30:46,190 --> 00:30:49,790
+كررناها زمان لما قلنا لكوا انه حتى بقى Cyclovere
+
+414
+00:30:49,790 --> 00:30:52,470
+اللي كنا بنستخدمه لل .. لل .. لل .. ال herpes
+
+415
+00:30:52,470 --> 00:30:56,190
+simplex type 1 و type 2 و لـ ال .. ال CMV okay
+
+416
+00:30:56,190 --> 00:31:00,310
+ممكن يخفف من الأعراض ممكن يشيلي ال virus اللي ..
+
+417
+00:31:00,310 --> 00:31:02,790
+اللي عامل ال infection الآن لكن ولا بأي حال من
+
+418
+00:31:02,790 --> 00:31:06,830
+الأحوال يستطيع ان يتخلص من ال tendency تبع ال
+
+419
+00:31:06,830 --> 00:31:12,050
+virus ATL is treated with anticancer chemotherapy
+
+420
+00:31:12,050 --> 00:31:14,910
+regimen يعني بعمله كأنه cancer و انتهى الموضوع
+
+421
+00:31:15,590 --> 00:31:18,150
+Antiviral drugs have not been effective in the
+
+422
+00:31:18,150 --> 00:31:23,310
+treatment of ham, corticosteroid and denasol have
+
+423
+00:31:23,310 --> 00:31:27,010
+produced improvement in some patients يعني عملوا
+
+424
+00:31:27,010 --> 00:31:31,310
+خلطة بين ال corticosteroid و ال denasol و أعطت بعض
+
+425
+00:31:31,310 --> 00:31:36,170
+التحسن في بعض المرضى لحظة كان مرة التواضع في لو
+
+426
+00:31:36,170 --> 00:31:41,410
+احنا اللي جينا حالة تحسنبنضخمها بس هنا لازم نكون
+
+427
+00:31:41,410 --> 00:31:45,570
+موضوعيين بالفعل و نقول انه النتائج تبعاتنا لم تعطي
+
+428
+00:31:45,570 --> 00:31:49,130
+تلك النتيجة للعالم there is no vaccine in H أو
+
+429
+00:31:49,130 --> 00:31:54,250
+against HTLV ال prevention strategies و احنا
+
+430
+00:31:54,250 --> 00:31:57,110
+قلنالكم انه كتير من الأمراض اللي يصعب علاجها
+
+431
+00:31:57,110 --> 00:32:04,110
+مائلنا الا غير انه نشوف الإجراءات المتبعة في عملية
+
+432
+00:32:04,110 --> 00:32:07,650
+اللي هو ال prevention و ال prevention على فكرة
+
+433
+00:32:07,650 --> 00:32:15,550
+يعنيإيه؟استراتيجية رايعة جدا وممكن احنا اللي كان
+
+434
+00:32:15,550 --> 00:32:17,890
+المفروض اليوم نعمل يوم دراسي عن ال infection
+
+435
+00:32:17,890 --> 00:32:21,270
+control وفي خضم الانشغال في اسبوع المضاد الحيوية
+
+436
+00:32:21,270 --> 00:32:25,370
+نسينا الموضوع خالص وما .. ماتبنروش فاحتمال يعني
+
+437
+00:32:25,370 --> 00:32:27,250
+على .. على نهاية الامتحانات تبعتكم ان شاء الله
+
+438
+00:32:27,250 --> 00:32:30,790
+نعمل يوم دراسي عن ال infection control ودوره
+
+439
+00:32:30,790 --> 00:32:33,990
+وادواته ويعني أشياء متعلقة بال infection control
+
+440
+00:32:33,990 --> 00:32:36,910
+فان شاء الله إذا كان في نصيب يعني تحضر هذا اليوم
+
+441
+00:32:36,910 --> 00:32:39,090
+الدراسي بيكون استفدت ان شاء الله .. ان شاء الله
+
+442
+00:32:39,090 --> 00:32:44,270
+كويسفبنقول إن ال infection control إلها آثار
+
+443
+00:32:44,270 --> 00:32:48,590
+إيجابية في منع الأمراض الموادية بشكل كبير و يجب أن
+
+444
+00:32:48,590 --> 00:32:52,010
+لا نستهين بها، و خاصة في الأمراض التي لا يمكن
+
+445
+00:32:52,010 --> 00:32:57,510
+علاجها بطريقة سهلة و معسرةscreening donated blood
+
+446
+00:32:57,510 --> 00:33:00,310
+for the presence of antibodies هذي أثبتت فعالية
+
+447
+00:33:00,310 --> 00:33:04,850
+كويسة لمنع اللي هو انتقال المرض عبر ل blood
+
+448
+00:33:04,850 --> 00:33:08,070
+transfusion يا هل طبعا ال blood transfusion هل هو
+
+449
+00:33:08,070 --> 00:33:12,150
+حجمه كبير كتير في الدنيا عشان نهتم فيه لها درجة
+
+450
+00:33:12,150 --> 00:33:16,380
+هذي؟ نعماسألوا بنك الدم في أي مستشفى من المستشفات،
+
+451
+00:33:16,380 --> 00:33:19,960
+قولوا حجم التبادل في الدم عندكم من جداش، بيقولوا
+
+452
+00:33:19,960 --> 00:33:22,960
+إن نسبه عالية جدا، الآن العملية الجراحية لازم يكون
+
+453
+00:33:22,960 --> 00:33:28,740
+في blood، يعني احتياط في هذه العمليةUsing condoms
+
+454
+00:33:28,740 --> 00:33:31,800
+to prevent sexual transmission يعني احتياطات او
+
+455
+00:33:31,800 --> 00:33:35,340
+الجنس الأمن يسموها Encouraging women with HTLV
+
+456
+00:33:35,340 --> 00:33:38,420
+antibodies to refrain from breastfeeding يعني لو
+
+457
+00:33:38,420 --> 00:33:43,920
+كانت أم صابة أو عندها antibodies لهذا الفيروس انه
+
+458
+00:33:43,920 --> 00:33:46,540
+تمتنع عن الرضاعة الطبيعية وتستبدلها بالرضاعة
+
+459
+00:33:46,540 --> 00:33:50,680
+الصينعية هيك بينقول احنا انتهينا من مجموعة اسمها
+
+460
+00:33:50,680 --> 00:33:57,560
+RNA Enveloped Virus طبعاإذا لاحظته إن الـHIV
+
+461
+00:33:57,560 --> 00:34:02,060
+المفروض يكون من ضمن المجموعة، بس مدرس نهوش، وبتالي
+
+462
+00:34:02,060 --> 00:34:05,360
+هذا أكيد إله ماله، إله وضع خاص، فبتالي إن شاء الله
+
+463
+00:34:05,360 --> 00:34:07,700
+هنطلع عليه بشكل منفصل بإذن الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ed1566c52283e2b04be0ed130a4ba837bcdce605
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/kxaD2NDIMGU_raw.srt
@@ -0,0 +1,1852 @@
+1
+00:00:20,940 --> 00:00:23,780
+بسم الله الرحمن الرحيم نكمل اليوم ان شاء الله أخر
+
+2
+00:00:23,780 --> 00:00:29,180
+فيروس في المحاضرة وهذا الفيروس يعتبر من عائلة ال
+
+3
+00:00:29,180 --> 00:00:35,260
+retro viruses وهو الأخ الشقيق لل HIV لكن هناك بعض
+
+4
+00:00:35,260 --> 00:00:37,860
+التشابهات وبعض الاختلافات سنترقل ان شاء الله في
+
+5
+00:00:37,860 --> 00:00:41,260
+هذه المحاضرة وحنشوف الأمراض اللي بيسببها وكيفية
+
+6
+00:00:41,260 --> 00:00:48,550
+إحداثه للسلطان في البشروالقالية المستخدمة من خلال
+
+7
+00:00:48,550 --> 00:00:51,810
+هذا البرنامج تختلف عن الانكو فيروس المعروفين اللي
+
+8
+00:00:51,810 --> 00:00:55,610
+هم بسببه السرطانة الصورة اللي جدانا بتوضح ان في
+
+9
+00:00:55,610 --> 00:01:00,530
+انديtwo copies of the same genome وهذا ينطبق على
+
+10
+00:01:00,530 --> 00:01:04,190
+ما قلنا سابقا بأن ال retrovirus يستحتوي على كلمة
+
+11
+00:01:04,190 --> 00:01:07,650
+diploid كلمة diploid يعني two copies of the same
+
+12
+00:01:07,650 --> 00:01:12,250
+gene مش قطعتين مختلفتين زي قطعة مختلفة زي ال
+
+13
+00:01:12,250 --> 00:01:16,110
+influenza أو زي ال rheovirus اللي هو ال retrovirus
+
+14
+00:01:16,110 --> 00:01:21,210
+لأ هم قطعتين نسختين من معنى أخر إنهم بيشبهوا بعض
+
+15
+00:01:26,120 --> 00:01:28,940
+هناك في ال retroviruses only two medically
+
+16
+00:01:28,940 --> 00:01:32,060
+important viruses اللي هم ال human T cell
+
+17
+00:01:32,060 --> 00:01:34,620
+lymphotropic virus اللي احنا قايد الدراسة اليوم
+
+18
+00:01:34,620 --> 00:01:38,740
+والثاني هو ال human immunodeficiency virus او ال
+
+19
+00:01:38,740 --> 00:01:43,000
+HIV الأمراض اللي بسببها هذا الفيروس اللي احنا بصدر
+
+20
+00:01:43,000 --> 00:01:46,420
+دراسته اليوم هم مرضين واحد هو عبارة عن cancer
+
+21
+00:01:46,420 --> 00:01:50,500
+ويسمى adult T cell leukemia او adult T cell
+
+22
+00:01:50,500 --> 00:01:55,100
+lymphoma لأنه بصيب ال lymphocytesو بالتحديد الـ
+
+23
+00:01:55,100 --> 00:02:00,480
+CD4 Plus Lymphocyte بذكركم بمين برضه؟ بالـ HIV،
+
+24
+00:02:00,480 --> 00:02:04,300
+الـ HIV برضه بصيب هذا النوع منها من الخلاياإن
+
+25
+00:02:04,300 --> 00:02:07,140
+المرض التاني عبارة عن neurological disease
+
+26
+00:02:07,140 --> 00:02:11,240
+neurological disease يعني مرض له علاقة بالأعصاب أو
+
+27
+00:02:11,240 --> 00:02:16,760
+بيسموه myelopathy او HTLV associated myelopathy و
+
+28
+00:02:16,760 --> 00:02:22,040
+بيختصروه HAN H A N كمان مرة HTLV associated
+
+29
+00:02:22,040 --> 00:02:25,940
+myelopathy إيه الأسماء التانية مش كتير معنين فيها
+
+30
+00:02:25,940 --> 00:02:31,400
+هناك نسخة أخرى من البيروت بيسموها HTLV-2 ويعتقد
+
+31
+00:02:31,400 --> 00:02:37,100
+إنها بتسبب نفس الأمراض لكنربطها بين الفيروس اللى
+
+32
+00:02:37,100 --> 00:02:42,100
+هو نسخة نين htlv2 وما بين المرضين اللى ذكرناهم قبل
+
+33
+00:02:42,100 --> 00:02:46,520
+قليل ال association مش بنفس قوة ال association ما
+
+34
+00:02:46,520 --> 00:02:51,860
+بين htlv1 و هدين المرضين بمعنى أخر ماعناش دلائل
+
+35
+00:02:51,860 --> 00:02:58,260
+بحجم الدلائل اللى بتتهم أو بتورط الأول في هدول
+
+36
+00:02:58,260 --> 00:02:58,760
+المرضين
+
+37
+00:03:01,490 --> 00:03:09,190
+الـHTLV والـHIV هما أشخاص مهمة في مصادر التجارة
+
+38
+00:03:09,190 --> 00:03:14,950
+كلاهما انفلوب واضح أننا نتكلم عن RNA انفلوب
+
+39
+00:03:14,950 --> 00:03:20,070
+فيروسات مع ترانسكربتيز يعني لديهم الانزيم الاسم
+
+40
+00:03:20,070 --> 00:03:22,170
+reverse transcriptase على الرغم من أنهم خدوا
+
+41
+00:03:22,170 --> 00:03:27,270
+بالكوا positive polarity RNA إذا لماذا بيلزم في
+
+42
+00:03:27,270 --> 00:03:32,040
+هذه الحالة reverse transcriptase؟طب ليش بيلزم
+
+43
+00:03:32,040 --> 00:03:36,060
+يتحول ل DNA؟
+
+44
+00:03:36,060 --> 00:03:40,400
+جزء من الcycle تبعت و ليش؟ بيعمل integration لأن
+
+45
+00:03:40,400 --> 00:03:42,560
+انا ساطر ان انا اعمل integration بRNA لازم اعمل
+
+46
+00:03:42,560 --> 00:03:46,200
+integration بمين؟ ب DNA إذا بيلزموا في هذه الحالة
+
+47
+00:03:46,200 --> 00:03:49,360
+اللي هو من عنده reverse transcriptase كلا هما
+
+48
+00:03:49,360 --> 00:03:54,220
+بيحتوي على reverse transcriptase both have
+
+49
+00:03:54,220 --> 00:03:57,520
+deployed كنا deployed يعني two copies of the same
+
+50
+00:03:57,520 --> 00:04:06,830
+genomeالان نجي للفرقات الفرق الاول hiv kills T
+
+51
+00:04:06,830 --> 00:04:13,690
+cells بينما ال htlv immortalize ايش معناه موت ايش
+
+52
+00:04:13,690 --> 00:04:18,730
+عكسها خلود مظبوط الموت عكسه خلود ال hiv بيموت
+
+53
+00:04:18,730 --> 00:04:23,020
+الخلية بينماهذا الفيروس بيعملها transformation إلى
+
+54
+00:04:23,020 --> 00:04:25,740
+cancer cell وانت بتعرف ان ال cancer cell is
+
+55
+00:04:25,740 --> 00:04:29,460
+immortal cell وبالتالي فيه فرق بين التانين لكن
+
+56
+00:04:29,460 --> 00:04:33,660
+خدوا بالكم سواء كانت ماتت ولا immortal ال function
+
+57
+00:04:33,660 --> 00:04:36,920
+تبعتها موجودة مش موجودة ال function وبالتالي
+
+58
+00:04:36,920 --> 00:04:42,080
+التانين هيولدوا sort of lower immunity يعني مش هم
+
+59
+00:04:42,080 --> 00:04:46,080
+بنقول immunodeficiency syndrome ال HIV وايضا كمان
+
+60
+00:04:46,080 --> 00:04:49,700
+هذا بيؤدي إلى نوع من انخفاض في جهاز المنعم
+
+61
+00:04:56,270 --> 00:05:00,130
+في فرصة أخرى متعرفة على الـ HIV من خلال هذا
+
+62
+00:05:00,130 --> 00:05:03,470
+الفيروس لأنه بتكلم على نفس ال structure تقريبا بين
+
+63
+00:05:03,470 --> 00:05:07,740
+الاتنين فمثلاكل الريتروفيروس بيحتوى على three
+
+64
+00:05:07,740 --> 00:05:11,520
+structural genes مشهورين جدا اسمهم جاج و بول و ان
+
+65
+00:05:11,520 --> 00:05:16,960
+فادولة اسمهم structural genes our virus contains
+
+66
+00:05:16,960 --> 00:05:21,340
+two functional genes او regulatory genes اسمهم TAX
+
+67
+00:05:21,340 --> 00:05:26,760
+and REX لحظة ال TAX and REX هتلاقي انه يلهم شبه
+
+68
+00:05:26,760 --> 00:05:31,660
+كبير بينهم وبين اللي هم ال functional او ال
+
+69
+00:05:31,660 --> 00:05:36,700
+regulatory genes تبعون ال HIV كلمة شبهفي الـ size
+
+70
+00:05:36,700 --> 00:05:40,600
+وفي ال structure وفي ال function طب إيه ده بيشبهوا
+
+71
+00:05:40,600 --> 00:05:44,140
+بعض في ال structure وبيشبهوا بعض في ال size وفي ال
+
+72
+00:05:44,140 --> 00:05:48,040
+function؟ ليش بيختلفوا عن بعض؟ ليش بيختلفوا عن
+
+73
+00:05:48,040 --> 00:05:51,600
+بعض؟ لو هم كلمة بيشبهوا مش identical يعني لو
+
+74
+00:05:51,600 --> 00:05:55,680
+identical كانوا نفس الاسم بس مش identical زي مثلا
+
+75
+00:05:55,680 --> 00:05:59,020
+ال gag و ال pull و ال inf identical فاطلهم نفس ال
+
+76
+00:05:59,020 --> 00:06:03,620
+ايه؟ نفس الاسم لكن هدولة اختلفوا بيدكركوا بس بنقطة
+
+77
+00:06:03,620 --> 00:06:12,100
+مهمة جداإنه قد نتشابه في ال size قد نتشابه في ال
+
+78
+00:06:12,100 --> 00:06:16,440
+function زي ما احنا الآن هنا طلاب هاي وظيفتنا طلاب
+
+79
+00:06:16,440 --> 00:06:21,120
+كنا بنمتلك عقل العقل ليهاش وظيفته يفكر ويدرس ويديب
+
+80
+00:06:21,120 --> 00:06:25,440
+على بقى في الامتحان تمام؟ هل الأداء اللي موجود في
+
+81
+00:06:25,440 --> 00:06:30,180
+الفصل للجميع الجميع بيشترك بيد الخاصية لكن هل
+
+82
+00:06:30,180 --> 00:06:35,350
+الأداء تبع الوظيفة بنفس الكفاءة؟أذكركم بمثال حقيقي
+
+83
+00:06:35,350 --> 00:06:41,550
+درسناه لما درسنا ال papilloma virus كنا في ال
+
+84
+00:06:41,550 --> 00:06:44,710
+papilloma virus يا بنات في بعض السلالات بعض
+
+85
+00:06:44,710 --> 00:06:48,830
+السلالات تعمل cancer cervical cancer وبعض السلالات
+
+86
+00:06:48,830 --> 00:06:52,290
+ماملش لما جينا اتطلعنا على الجينات المسؤولة رجاله
+
+87
+00:06:52,290 --> 00:06:57,790
+مائية ستة و اية سبعةE6 وE7 الموجودين في كل ال
+
+88
+00:06:57,790 --> 00:07:02,130
+Papilloma Viruses ايش معنى 16 و18 هم اللي عملوا
+
+89
+00:07:02,130 --> 00:07:05,630
+cancer و الباقيين اللي عملوش cancer مع انه كلهم
+
+90
+00:07:05,630 --> 00:07:10,230
+بيحتوي على E6 وE7 فسرناكوا في حينها قلنالكوا ان
+
+91
+00:07:10,230 --> 00:07:13,470
+البروتينات اللي خارجة من ال E6 وE7 من هدول
+
+92
+00:07:13,470 --> 00:07:17,290
+السلالتين اكتر قدرة على الارتباط بال
+
+93
+00:07:17,290 --> 00:07:21,030
+Retinoplastoma و ال B53 proteins
+
+94
+00:07:22,470 --> 00:07:29,010
+وبالتالي هي ليست الوظيفة وانما مستوى أداء الوظيفة
+
+95
+00:07:29,010 --> 00:07:32,670
+هو اللي عمل فرق، كمان مرة ليست الوظيفة بحد ذاتها
+
+96
+00:07:32,670 --> 00:07:35,930
+وانما مستوى أداء هذه الوظيفة
+
+97
+00:07:38,530 --> 00:07:43,230
+طبعا هذا الكلام احنا بنأكد عليه عشان انه نفسر كثير
+
+98
+00:07:43,230 --> 00:07:48,850
+من الأشياء اللي احنا قد يعني تشترك فيها الفيروسات
+
+99
+00:07:48,850 --> 00:07:52,910
+لكن ال outcomes او النتائج المخرجات تبعتها تكون
+
+100
+00:07:52,910 --> 00:07:53,710
+مختلفة
+
+101
+00:07:56,260 --> 00:08:00,920
+طبعا فينا كمان شغل مهم مثلها انا انه بيقولنا انه
+
+102
+00:08:00,920 --> 00:08:06,700
+اختلاف بسيط في ال amino acid sequence ادى الاختلاف
+
+103
+00:08:06,700 --> 00:08:12,980
+في ال antigenicity بين ال HIV و ال HTLV
+
+104
+00:08:13,690 --> 00:08:19,310
+ومثال تاني بتأكيد على المثال الـ B24 is a major
+
+105
+00:08:19,310 --> 00:08:24,490
+nucleocapsid protein in both HTLV and HIV but they
+
+106
+00:08:24,490 --> 00:08:27,990
+differ antigenically لأنه جدالكو اختلاف بسيط في ال
+
+107
+00:08:27,990 --> 00:08:34,230
+amino acid sequenceالـ Varian لـ both HTLV and HIV
+
+108
+00:08:34,230 --> 00:08:36,710
+Contains a reverse transcriptase وحكينا على كلام
+
+109
+00:08:36,710 --> 00:08:40,510
+لكن كمان بتحتوي Integrase و Protease ليش
+
+110
+00:08:40,510 --> 00:08:43,310
+Integrase؟ لأن احنا بدنا نعمل integration للجينوم
+
+111
+00:08:43,310 --> 00:08:47,590
+تبع الفيروس إلى داخل اللي هو ال host cell طب ليش
+
+112
+00:08:47,590 --> 00:08:51,910
+بدنا Protease؟ لأنه إذا فاكرين لما درسنا لبروتين
+
+113
+00:08:51,910 --> 00:08:56,170
+في ال virus structure قلنا هناك بعض الفيروسات لا
+
+114
+00:08:56,170 --> 00:09:00,810
+تستطيعلتستطيع أن تنتج functional protein، تنتجها
+
+115
+00:09:00,810 --> 00:09:05,730
+اسمها precursor polypeptide، فتحتاج البروتييز to
+
+116
+00:09:05,730 --> 00:09:09,910
+cut this precursor into functional proteins أو
+
+117
+00:09:09,910 --> 00:09:11,170
+polypeptide
+
+118
+00:09:13,250 --> 00:09:17,450
+الـ Envelope Protein في الـHTLV بتحتوي على GP46 و
+
+119
+00:09:17,450 --> 00:09:23,430
+GP21 بينما في الـHIV بتحتوي على GP120 و GP41 طبعا
+
+120
+00:09:23,430 --> 00:09:26,050
+كل كلمة بتحدث عن ان الـ Envelope Protein في
+
+121
+00:09:26,050 --> 00:09:33,730
+الـHTLV هم GP46 و GP21 هدولة مقابلهمفي الـHIV كان
+
+122
+00:09:33,730 --> 00:09:38,390
+فينا الـGP120 والـGP41 طبعا هدول الـGlycoproteins
+
+123
+00:09:38,390 --> 00:09:42,570
+هم عبارة عن spikes على ال envelopes و هم المسؤولين
+
+124
+00:09:42,570 --> 00:09:46,750
+عن الارتباط بالـ host cell اللي هي الـCD4 في هذه
+
+125
+00:09:46,750 --> 00:09:54,610
+الحالة لان نجي لاريجولاتوريا البروتينز كنا فيه TAX
+
+126
+00:09:54,610 --> 00:09:59,420
+و فيه REX مظبوطومقابلهم في الـHIV في حاسمة TAT
+
+127
+00:09:59,420 --> 00:10:03,520
+وحاسمة REV لحظة انهم بيشتركوا بالأول حرفين
+
+128
+00:10:03,520 --> 00:10:10,220
+وبيختلفوا بالحرف التالت تاكس تات ريكس ريف تمام؟
+
+129
+00:10:10,220 --> 00:10:14,320
+الآن الـ Tax Protein هو الأهم على الإطلاق وحنشوف
+
+130
+00:10:14,320 --> 00:10:19,540
+الآن جداش مهمته في إحداث الكانسر مثلا بقولنا Tax
+
+131
+00:10:19,540 --> 00:10:22,560
+Protein is a transcriptional activator
+
+132
+00:10:24,810 --> 00:10:28,270
+بدى قبل ما أبدأ أشرح عنه بنتكلم على موضوع اللي هو
+
+133
+00:10:28,270 --> 00:10:32,910
+ال viruses و إحداثها لانكوجين لل human هذا هو
+
+134
+00:10:32,910 --> 00:10:36,430
+المعتاد اللي احنا بنعرفه في الانكو viruses هذا ال
+
+135
+00:10:36,430 --> 00:10:41,190
+virus لا بيعمل هيك لا بيحمل انكوجين ولا بيعمل
+
+136
+00:10:41,190 --> 00:10:46,610
+insertion لانكو جنب انكوجين طبعا كيف بيشتغل؟ كل
+
+137
+00:10:46,610 --> 00:10:49,690
+اعتماد البناء العالمين على ال tax protein اللي هو
+
+138
+00:10:49,690 --> 00:10:55,880
+transcriptional activator كيف بيشتغل؟الـ
+
+139
+00:10:55,880 --> 00:10:58,940
+activation of transcription of both cellular and
+
+140
+00:10:58,940 --> 00:11:02,140
+viral mRNA synthesized by a tax protein that
+
+141
+00:11:02,140 --> 00:11:06,500
+initiate oncogenesis يبجى هو بيجي بينهم و بيمروا
+
+142
+00:11:06,500 --> 00:11:10,220
+على كل الجينات سواء كانت فيروسية أو أدمية و
+
+143
+00:11:10,220 --> 00:11:14,560
+بيعملها transcription بيعمل تنشيط لمين؟ للـ
+
+144
+00:11:14,560 --> 00:11:19,420
+transcription يبجى هتطلع بروتينات عديدة من ضمن هذه
+
+145
+00:11:19,420 --> 00:11:24,140
+البروتينات ابنات الـ Interleukin-2الـ Interlochen
+
+146
+00:11:24,140 --> 00:11:29,120
+II قائد مهم جدا في جهاز المناعة لكن لابد أن يكون
+
+147
+00:11:29,120 --> 00:11:35,540
+قائد واحدبعدد محدود من الأوامر، تمام؟ لو صار عندنا
+
+148
+00:11:35,540 --> 00:11:40,580
+عشرة، عشرة قادة، وكل واحد بيعطي أوامر، تمام؟ أكيد
+
+149
+00:11:40,580 --> 00:11:45,300
+حيصير في عندنا خلل، بالإضافة إلى العاصفة اللي نتجت
+
+150
+00:11:45,300 --> 00:11:48,700
+عن كل البروتينات الجديدة اللي طلعت، اللي المفروض
+
+151
+00:11:48,700 --> 00:11:52,740
+ماتطلعش، طلعت لأنه في activator اللي موجود في هذا
+
+152
+00:11:52,740 --> 00:11:57,520
+الفيروس، فبصير في عندي hyper activity في الخلية
+
+153
+00:11:58,130 --> 00:12:01,470
+وانتوا عارفين ان ال cancer cell uncontrolled
+
+154
+00:12:01,470 --> 00:12:06,630
+growth غير مسيطر عليه وهذا اللي بيحدث بالفعل في
+
+155
+00:12:06,630 --> 00:12:10,470
+الخليج، مين اللي بيساهم فيه؟ اللي هو ال tax
+
+156
+00:12:10,470 --> 00:12:13,570
+protein اللي هو قابل عن ال transcriptional
+
+157
+00:12:13,570 --> 00:12:18,700
+activator proteinالان في كامة نقطة مهمة لازم
+
+158
+00:12:18,700 --> 00:12:21,920
+نعرفها ان هذا الفيروس is much more stable او
+
+159
+00:12:21,920 --> 00:12:26,900
+الجينات تبعته is much more stable than HIV هدى ال
+
+160
+00:12:26,900 --> 00:12:29,940
+stability فى صالح مين؟ فى صالح ال HIV ولا فى صالح
+
+161
+00:12:29,940 --> 00:12:30,660
+هذا الفيروس؟
+
+162
+00:12:33,300 --> 00:12:37,220
+أكيد في صالح ال HIV ال instability في صالح الفيروس
+
+163
+00:12:37,220 --> 00:12:42,100
+دايما ليش لأنه دايما بيغير من من جيناته يبقى بيغير
+
+164
+00:12:42,100 --> 00:12:46,020
+من انتجناته لما بقول ان هذا الفيروس stable او مش
+
+165
+00:12:46,020 --> 00:12:49,260
+stable بيكونوا يعرفوا انه لها consequence ال
+
+166
+00:12:49,260 --> 00:12:54,160
+stable يعني زي ال smallpox stable الفيروس مالوش
+
+167
+00:12:54,160 --> 00:12:57,900
+الغير كان ايه one single strain هذا له two strains
+
+168
+00:12:57,900 --> 00:13:03,590
+اذا عرفناهم اللي هم hdlv-1 و hdlv-2الصورة اللى
+
+169
+00:13:03,590 --> 00:13:07,950
+قدامنا اتطلع عليها منيح لو انا مش مكتوب عليها كلام
+
+170
+00:13:07,950 --> 00:13:11,550
+هذا الكلام مش مكتوب عليها كان بقول يمكن هذا hiv
+
+171
+00:13:11,550 --> 00:13:15,510
+لأنهم بيشبهوا بعض كتير هم ايش الفرق بينهم فاكرين
+
+172
+00:13:15,510 --> 00:13:22,650
+ال GP's GP 46 و GP وينه 21 تمام هدول اللى بيبقوا
+
+173
+00:13:22,650 --> 00:13:26,830
+معاهم بيرتبطوا ب ال receptors اللى موجودة في ال
+
+174
+00:13:26,830 --> 00:13:33,330
+CD4 plus cellsكيف ينتقل هذا الفيروس؟ احنا بنعرف ان
+
+175
+00:13:33,330 --> 00:13:35,590
+الـHIV بينتقل عن طريق الـGens، بينتقل عن طريق
+
+176
+00:13:35,590 --> 00:13:38,910
+الدم، بينتقل عن طريق اللي هو ال .. برضه ال ..
+
+177
+00:13:38,910 --> 00:13:42,130
+اعتقد انه نفس ال .. نفس الفكرة انتقال، لكن
+
+178
+00:13:42,130 --> 00:13:45,890
+بالاضافة لذلك في عندي اللي هو الـbreast feeding من
+
+179
+00:13:45,890 --> 00:13:49,910
+رضاعة الطبيعي Intravenous drug use, sexual contact
+
+180
+00:13:49,910 --> 00:13:55,890
+or breast feeding هناك بعض اثباتات غير مؤكدة بإنه
+
+181
+00:13:55,890 --> 00:13:59,030
+ممكن انتقل الـtrans placental من الأم إلى الجنين
+
+182
+00:14:00,890 --> 00:14:03,950
+الترانسبيشن عبر البلد مدى ما بينتقل عن طريق ال
+
+183
+00:14:03,950 --> 00:14:06,850
+drug .. drug intravenous drug use بجهة أكيد بنتقل
+
+184
+00:14:06,850 --> 00:14:10,090
+عن طريق ال blood transfusion لكن في بنوك الدم في
+
+185
+00:14:10,090 --> 00:14:12,470
+تلك البلدان اللي فيها هذا الفيروس المنتشر بشكل
+
+186
+00:14:12,470 --> 00:14:16,710
+كبير أصبح جزء من ال screening لل blood bags أن
+
+187
+00:14:16,710 --> 00:14:22,120
+نفحص عن ال antibodies تبع ال HTLVفأي blood bag
+
+188
+00:14:22,120 --> 00:14:26,240
+فحصة positive لهذا الفيروس it will be discarded
+
+189
+00:14:26,240 --> 00:14:31,000
+وبتالي عدد حالة الانتقال عبر ال blood transfusion
+
+190
+00:14:31,000 --> 00:14:35,740
+لهذا المرة تقريبا zero Transmission is thought to
+
+191
+00:14:35,740 --> 00:14:39,500
+occur هذه نقطة كتير برضه مهمة يعني برضه غريبة ان
+
+192
+00:14:39,500 --> 00:14:44,220
+ال virus بينتقلش بشكل حر يا بنات بينتقل عبر خلية
+
+193
+00:14:44,220 --> 00:14:49,340
+مصابة إذا يجب أن ينتقل من إنسان إلى إنسان تمام
+
+194
+00:14:49,340 --> 00:14:54,280
+لإنفساعة مصابةLymphocyte مصابر مش الفيروس ال free
+
+195
+00:14:54,280 --> 00:15:01,040
+وانما ال lymphocyte مثلا بقولنا انه في المثال اللي
+
+196
+00:15:01,040 --> 00:15:04,660
+اعتقد اللي وراه على طول ال whole blood مش ال
+
+197
+00:15:04,660 --> 00:15:09,300
+plasma اللي بتنجل الفيروسكمان الـ infected
+
+198
+00:15:09,300 --> 00:15:13,420
+lymphocyte في السائل المنوي هي المسئولة عن نقل
+
+199
+00:15:13,420 --> 00:15:18,500
+الفيروس عبر اللي هو ال sexual contact، إذا خلايا
+
+200
+00:15:18,500 --> 00:15:23,940
+مصابة و ليست فيروسات حرة هي المسئولة عن الانتقال
+
+201
+00:15:24,980 --> 00:15:28,140
+هناك مناطق عالميا معروفة ان فيها نسبة عالية من هذا
+
+202
+00:15:28,140 --> 00:15:30,660
+الفيروس زي الـ Caribbean Region في Southern
+
+203
+00:15:30,660 --> 00:15:33,800
+Florida و Eastern South America في Western Africa
+
+204
+00:15:33,800 --> 00:15:37,880
+و Southern Japan لكن على الرغم من ان في هذه
+
+205
+00:15:37,880 --> 00:15:41,640
+البلدان أو هذه المناطق يعني قد تصل نسبة الإصابة
+
+206
+00:15:41,640 --> 00:15:47,880
+إلى عشرين بالمائة من السكانإلا إنه مش لازم نغفل إن
+
+207
+00:15:47,880 --> 00:15:51,420
+هؤلاء الناس في تلك المناطق لن يبقوا في تلك
+
+208
+00:15:51,420 --> 00:15:54,620
+المناطق، يعني هم بيتحركوا، بيسافروا، بيهاجروا،
+
+209
+00:15:54,620 --> 00:15:58,180
+ممكن يقضوا أو قط، أوطل هنا أو هناك، وبالتالي هم
+
+210
+00:15:58,180 --> 00:16:03,020
+ناقلين للفيروس، يعني نقدر نقول إن الفيروس should
+
+211
+00:16:03,020 --> 00:16:09,860
+be expected all over the worldولا نص المصابين اللي
+
+212
+00:16:09,860 --> 00:16:12,220
+كانوا في ولاية المتحدة، مش نص ولاية المتحدة، نص
+
+213
+00:16:12,220 --> 00:16:16,020
+المصابين من ولاية المتحدة كانوا مصابين بالنسخة
+
+214
+00:16:16,020 --> 00:16:22,500
+التانية اللي هي الـHTLV2 واللي غالبا تنتقل عبر
+
+215
+00:16:22,500 --> 00:16:25,820
+الـIntravenous Drug Use، يعني تبعهم المخدرات هم
+
+216
+00:16:25,820 --> 00:16:29,560
+اللي بيصابوا بهذا الفيروس
+
+217
+00:16:32,280 --> 00:16:36,760
+أحنا ذكرنا في المقدمة أنه في مرضين مهمين ومنفصلين
+
+218
+00:16:36,760 --> 00:16:41,360
+تماما بسببهم هذا الفيروس اللي هم الـ other T cell
+
+219
+00:16:41,360 --> 00:16:46,860
+leukemia أو ATL والـHTLV infection للـ CD4 T
+
+220
+00:16:46,860 --> 00:16:49,500
+lymphocyte بيعمل malignant transformation يعني
+
+221
+00:16:49,500 --> 00:16:54,700
+cancer يعني cancer والـHTLV في هذه الحالة latent
+
+222
+00:16:54,700 --> 00:16:58,420
+within the malignant cells هذا اللي .. هذا ال ..
+
+223
+00:16:58,420 --> 00:17:01,640
+ال .. ال .. ال .. ال ..اللي بيخلّي الكلام اللي
+
+224
+00:17:01,640 --> 00:17:05,300
+احنا حكيناه قبل قليل يكون له معنى انه الانتقال عبر
+
+225
+00:17:05,300 --> 00:17:09,380
+الـ lymphocytes و ليس عبر اللي هو قولنا ال .. ال
+
+226
+00:17:09,380 --> 00:17:13,080
+.. نعم لأن
+
+227
+00:17:13,080 --> 00:17:16,440
+الـHTLV is typically not produced by the malignant
+
+228
+00:17:16,440 --> 00:17:20,180
+cell إذا الخلية صارت malignant، غالباً الفيروس ما
+
+229
+00:17:20,180 --> 00:17:24,680
+.. يعني مابيطلعش منها، بيظل موجود جوا، ليش؟ لأنه
+
+230
+00:17:24,680 --> 00:17:31,310
+هي لما بتتكاثر، هوالـ Provirus بتكثر مع هذه الخلية
+
+231
+00:17:31,310 --> 00:17:35,530
+الشكل
+
+232
+00:17:35,530 --> 00:17:38,310
+التاني من المعروف اللي قلنا سميناه ham او HTLV
+
+233
+00:17:38,310 --> 00:17:41,670
+-associated myelopathy الاحتلال العصبي المصاحب
+
+234
+00:17:41,670 --> 00:17:45,750
+لفيروس الـ HTLV وقلنا له أسماء أخرى tropical
+
+235
+00:17:45,750 --> 00:17:49,050
+spastic paraparesis paraparesis معناها ارتخاء
+
+236
+00:17:49,050 --> 00:17:53,810
+عضلات او شلال وspastic معناها انقباضي او chronic
+
+237
+00:17:54,780 --> 00:17:58,560
+progressive myelopathy وكلمة chronic يعني مزمن
+
+238
+00:17:58,560 --> 00:18:03,160
+يعني طويل الأماد progressive بيصيب الإنسان في لحظة
+
+239
+00:18:03,160 --> 00:18:07,700
+معينة باعتلال بسيط وبيتطور هذا الاعتلال وبيزداد مع
+
+240
+00:18:07,700 --> 00:18:13,050
+أيه مع الزمن لكن على فترة طويلةكمان الهام عبارة عن
+
+241
+00:18:13,050 --> 00:18:17,170
+demyelinating disease لكل من الدماغ و ال spinal
+
+242
+00:18:17,170 --> 00:18:22,590
+cord و يؤثر أكثر على ال motor neurons و لما يؤثر
+
+243
+00:18:22,590 --> 00:18:26,510
+على ال motor neurons اللي هي الخلايا العصبية
+
+244
+00:18:26,510 --> 00:18:31,530
+الحركية أكيد برضه هيؤثر على الشلب أو يعمل الشلب
+
+245
+00:18:31,530 --> 00:18:42,670
+الآن بدنا نفهم النظرية اللي بتفسر حدوث الهامو هي
+
+246
+00:18:42,670 --> 00:18:47,870
+تتنافع مع ممكن كلام ذكرناه سابقا فهنحاول نوفق بين
+
+247
+00:18:47,870 --> 00:18:53,890
+المعناين بطريقة ما ham is caused by an autoimmune
+
+248
+00:18:53,890 --> 00:18:57,470
+cross reaction autoimmune cross reaction يعني
+
+249
+00:18:57,470 --> 00:19:03,550
+المفروض ان ال antibodies الموجهة للفيروس ماترتبتش
+
+250
+00:19:03,550 --> 00:19:08,050
+مع مين؟ مع خلائنا لكن كلمة cross reaction معناها
+
+251
+00:19:08,050 --> 00:19:11,580
+الحاجة انه صار في ارتباطin which the immune
+
+252
+00:19:11,580 --> 00:19:16,980
+response against HTLV damages the neuron or، هذا
+
+253
+00:19:16,980 --> 00:19:21,740
+احتمال تاني، by cytotoxic T-cells that kills HTLV
+
+254
+00:19:21,740 --> 00:19:25,060
+infected in neurons احنا بنعرف انه الجهاز العصبي
+
+255
+00:19:25,060 --> 00:19:31,210
+في الإنسان من الأماكن المحمية من جهاز المناعةويمكن
+
+256
+00:19:31,210 --> 00:19:33,990
+ذكرنا هذا الكلام في نقاش سابق ان it is protected
+
+257
+00:19:33,990 --> 00:19:37,290
+لأن اي بيروس بدي يصلي هنا الخلايا هذه و يصلي ال
+
+258
+00:19:37,290 --> 00:19:42,110
+toxic T cell تيجي تدمره اذا دمرته معناه الحكي انه
+
+259
+00:19:42,110 --> 00:19:46,330
+فينا خلل لان الخلية العصبية اللي بتموت فش غيرها،
+
+260
+00:19:46,330 --> 00:19:52,850
+مظبوط؟ فهو من ال privilege ساعت في الجسم
+
+261
+00:19:53,630 --> 00:19:57,770
+لكن لما ييجي antibody cross-reacting ويرتبط فيه
+
+262
+00:19:57,770 --> 00:20:03,650
+الارتباط بيعمل marking التليفوسيات تفهمش كتير إلا
+
+263
+00:20:03,650 --> 00:20:08,130
+إشارات معينةفال mark هذه ان هذا ال antibody مرتبط
+
+264
+00:20:08,130 --> 00:20:11,510
+بهذه الخلية يبقى هذه mark او اشارة لل T cell تعيط
+
+265
+00:20:11,510 --> 00:20:15,750
+T cell اقتل هذه الخلية فهذا قد يكون السبب ان في ال
+
+266
+00:20:15,750 --> 00:20:19,450
+cross reaction ذهبت ال antibodies الى ال neurons
+
+267
+00:20:19,450 --> 00:20:24,950
+وبالتالي اعطت wrong information ل ال T cells اللي
+
+268
+00:20:24,950 --> 00:20:26,330
+قتلت هذه ال neurons
+
+269
+00:20:29,980 --> 00:20:33,940
+لـ Clinical findings الـ ATL is characterized by
+
+270
+00:20:33,940 --> 00:20:37,660
+lymphadenopathy, hepatospinomegaly, lytic bone,
+
+271
+00:20:38,280 --> 00:20:42,880
+bone lesions, and skin lesions كل هذه الليشين اللي
+
+272
+00:20:42,880 --> 00:20:46,240
+هملك عنها و الهيباتوميجالي و الاسبينوميجالي ناتجة
+
+273
+00:20:46,240 --> 00:20:51,700
+عن تكاثر اللي هو الـ T cell infiltrating these
+
+274
+00:20:51,700 --> 00:20:56,360
+organs عشان infiltrating تتسلل إلى هذه الأعضاء
+
+275
+00:20:58,570 --> 00:21:04,090
+في الدم الماريجنان تي سيل لها شكل حلو كتير بيسموه
+
+276
+00:21:04,090 --> 00:21:08,070
+flower-shaped nucleus هنشوف صورة كمان شوية له صورة
+
+277
+00:21:08,070 --> 00:21:13,530
+جميلة لمرض خبيث hypercalcemia due to increased
+
+278
+00:21:13,530 --> 00:21:15,850
+osteoclastic activity شوفتوا قبل شوية احنا اتكلمنا
+
+279
+00:21:15,850 --> 00:21:20,070
+عن مين؟ عن lytic bone صح؟ فالـ lytic bone يعني فيه
+
+280
+00:21:20,070 --> 00:21:23,790
+ان خلايا عظمية بتتحلل خلايا عظمية بتتحلل ليش بيطلع
+
+281
+00:21:23,790 --> 00:21:27,230
+منها كالسيوم فبصير لنا نسبة كالسيوم عالية في هذا
+
+282
+00:21:27,230 --> 00:21:32,490
+الحالPatients with ATL often have reduced cell
+
+283
+00:21:32,490 --> 00:21:37,570
+-mediated immunity.عظم اني لما بنقول CD4 cells صار
+
+284
+00:21:37,570 --> 00:21:41,350
+فيها infection قل عددها السليمة يبقى معناه الحكي
+
+285
+00:21:41,350 --> 00:21:43,730
+ان هو بالفعل في عندي reduced cell-mediated
+
+286
+00:21:43,730 --> 00:21:48,630
+immunity وبالتالي هو الآن جريب لأخو ال HIV انه
+
+287
+00:21:48,630 --> 00:21:52,850
+بيخفض جهاز المنع طبعا لكن فعال اكتر اللي هو ال HIV
+
+288
+00:21:52,850 --> 00:21:56,270
+more effective in reducing immunity than this
+
+289
+00:21:56,270 --> 00:22:00,310
+diseaseطب يتصور عندنا سيل ميديا الـ immunity
+
+290
+00:22:00,310 --> 00:22:04,850
+depressed بصير عندي opportunistic infection with
+
+291
+00:22:04,850 --> 00:22:10,520
+fungi and other viruses ال clinical pictureof ham
+
+292
+00:22:10,520 --> 00:22:13,960
+include gait وكلمة gait معناها walking
+
+293
+00:22:13,960 --> 00:22:20,500
+disturbances يعني مشكلة في الحركة وهذا نتج عن ضعف
+
+294
+00:22:20,500 --> 00:22:26,900
+العضلات اللي بتصيب ال lower limbs اللي هي الأطراف
+
+295
+00:22:26,900 --> 00:22:33,830
+السفلية و أيضا يصحي ذلك low back painممكن يكون فيه
+
+296
+00:22:33,830 --> 00:22:39,030
+فقدان للسيطرة على التبول والتبرز في بعض الحالات
+
+297
+00:22:39,030 --> 00:22:44,850
+ايضا كما ذكرنا في السابق ان فقدان الخلايا الحركية
+
+298
+00:22:44,850 --> 00:22:50,250
+بيكون لصالح او فقدان الحركة اكتر من فقدان الاحساس
+
+299
+00:22:50,250 --> 00:22:53,810
+في هذه الحالة لانه تأثير اكتر على الموتور النيور
+
+300
+00:22:55,070 --> 00:22:58,130
+هذه الصورة اللى ذكرناها قبل قليل قلنالكوا ان ال
+
+301
+00:22:58,130 --> 00:23:03,570
+nucleus بتكون عاملة زى الزهرة تمام فصورة جميلة
+
+302
+00:23:03,570 --> 00:23:11,050
+لكنها لمرض خبيث لأن هذا cancerطبعا ال .. ال .. ال
+
+303
+00:23:11,050 --> 00:23:12,950
+.. الـ T cell flower shape nucleus can also be
+
+304
+00:23:12,950 --> 00:23:16,630
+found in the spinal fluid، magnetic resonance
+
+305
+00:23:16,630 --> 00:23:19,450
+imaging اللي هو ال MRI، بتسمع بال MRI؟ اللي هي
+
+306
+00:23:19,450 --> 00:23:23,190
+تصوير ال .. ال .. ال .. الرنين، تصوير الرنين،
+
+307
+00:23:23,190 --> 00:23:27,650
+ماعطيناش أي specific findings، يعني بنشوف ال .. أو
+
+308
+00:23:27,650 --> 00:23:30,410
+ال .. ال .. الطبيب اللي عشانها، بيشوف إن هو هذا
+
+309
+00:23:30,410 --> 00:23:34,450
+المريض normal في الغالبprogression of symptoms
+
+310
+00:23:34,450 --> 00:23:37,930
+occur slowly or over a period of years يعني في بطء
+
+311
+00:23:37,930 --> 00:23:42,750
+زي ما ذكرنا أو على مدار سنوات طويلة ham occur
+
+312
+00:23:42,750 --> 00:23:48,440
+primarily in women of middle ageمنتصف العمر، the
+
+313
+00:23:48,440 --> 00:23:51,900
+disease resemble multiple sclerosis، فيه فرق بين
+
+314
+00:23:51,900 --> 00:23:55,960
+multiple sclerosis وبين هذا ال disease، إنه هذاك
+
+315
+00:23:55,960 --> 00:23:59,300
+بيشفى، ال multiple sclerosis فيه remission، بينما
+
+316
+00:23:59,300 --> 00:24:03,240
+هذا المرض ما بيصير فيه أنه remission، غالبا التطور
+
+317
+00:24:03,240 --> 00:24:09,060
+بيكون إلى الأسوأATL و ham are relatively rare
+
+318
+00:24:09,060 --> 00:24:11,460
+disease فاكرين لما اقول ان اجاب شوية عشرين بالمية
+
+319
+00:24:11,460 --> 00:24:14,480
+في بعض المناطق؟ العشرين بالمية لا تعني ان كل
+
+320
+00:24:14,480 --> 00:24:19,980
+العشرين بالمية سيتحولوا اليه اللي هو ATL او ham،
+
+321
+00:24:19,980 --> 00:24:25,320
+نسبة ضئيلة من هؤلاء المرضى ممكن يطوروا ATL او ham
+
+322
+00:24:26,220 --> 00:24:29,040
+The vast majority of people infected with HTLV
+
+323
+00:24:29,040 --> 00:24:32,980
+develop asymptomatic infection, usually detected
+
+324
+00:24:32,980 --> 00:24:35,840
+by the presence of antibody. اصلا كيف انا افهم انه
+
+325
+00:24:35,840 --> 00:24:40,920
+20% من الناس من خلال الهو testing of blood donors
+
+326
+00:24:40,920 --> 00:24:44,680
+لما بيجينا blood donor احنا مش بنفحصه احنا لل HIV
+
+327
+00:24:44,680 --> 00:24:48,420
+مثلا في غزة هانا و لل Hepatitis B و لل Hepatitis C
+
+328
+00:24:48,420 --> 00:24:51,500
+وعرفش اذا كان بيفحصه لاشياء اخرى بس انا اعتقد ان
+
+329
+00:24:51,500 --> 00:24:54,930
+هاي الأمراض اللي بيفحصوها routinelyالأقل لو كان
+
+330
+00:24:54,930 --> 00:24:59,690
+عندنا HT ال human T cell نعم ال .. ال ..
+
+331
+00:24:59,690 --> 00:25:04,190
+الينفوسايت جنهة فيروس وكانت تستنج ابنين دي لما
+
+332
+00:25:04,190 --> 00:25:08,170
+نعرف جداش ال population اللي كان عندهم Antibody من
+
+333
+00:25:08,170 --> 00:25:12,470
+خلال ال blood testing لل blood donors و هذا الكلام
+
+334
+00:25:12,470 --> 00:25:16,630
+بيسويه في كتير في مدينة العالم انه بدل ما ياخدوا
+
+335
+00:25:16,630 --> 00:25:19,170
+عينات من .. و الناس عاديين بيروح على بنك .. على
+
+336
+00:25:19,170 --> 00:25:23,690
+بنك الدموبيقعدوا هناك بنك الدم الباحثين وبيدوروا
+
+337
+00:25:23,690 --> 00:25:26,870
+على ال prevalence of diseases من خلال ال blood
+
+338
+00:25:26,870 --> 00:25:30,070
+وانا اقول انهم معينة ممثل عالمين عن المجتمع اللي
+
+339
+00:25:30,070 --> 00:25:36,110
+هم موجودين فيه okay only a small subset of those
+
+340
+00:25:36,110 --> 00:25:39,590
+infected will develop either ATL or HAM إذا النسبة
+
+341
+00:25:39,590 --> 00:25:44,450
+ضئيلة من هؤلاء الذين يصابون قد يطوروا ATL أو HAM
+
+342
+00:25:45,820 --> 00:25:50,880
+الـ lab diagnosis لهذه المرضين ممكن نكشف عنهم من
+
+343
+00:25:50,880 --> 00:25:54,260
+خلال الـ ELISA test to detect antibodies in
+
+344
+00:25:54,260 --> 00:25:57,900
+patient serum، إذا فهي إمكانية لقياس الـ antibody
+
+345
+00:25:58,810 --> 00:26:02,270
+طبعا زي ما ال HIV ال western blood هو ال
+
+346
+00:26:02,270 --> 00:26:06,690
+confirmatory test ايضا هو هنا ال confirmatory test
+
+347
+00:26:06,690 --> 00:26:10,050
+انتوا عارفين إليزا في كثير من الفحوصات تعتبر
+
+348
+00:26:10,050 --> 00:26:14,170
+screening كده بدنا نعمل confirmation بدنا نعمل
+
+349
+00:26:14,170 --> 00:26:17,570
+western blood في هذا الحال is used to confirm a
+
+350
+00:26:17,570 --> 00:26:21,240
+positive ELISA resultإذاً الـ ELISA لو جالت
+
+351
+00:26:21,240 --> 00:26:23,520
+negative فهو negative، لكن لو positive، it should
+
+352
+00:26:23,520 --> 00:26:27,640
+be confirmed by Western blood عشان هي كبنات لازم
+
+353
+00:26:27,640 --> 00:26:32,020
+يكونوا عارفين في مستويات التقارير، التحاليل،
+
+354
+00:26:32,020 --> 00:26:38,090
+ماينفعش نستعجل و نعطي المرضى نتائجيعني في بعض ..
+
+355
+00:26:38,090 --> 00:26:42,790
+في حالة أذكرها جيدا طلعت عنها في أحد المختبرات و
+
+356
+00:26:42,790 --> 00:26:46,830
+أنا كنت أشعر أعمل في ذاك المختبر طلعت عنها VDRL أو
+
+357
+00:26:46,830 --> 00:26:49,890
+RBR بتاعة الـ syphilis طلعت positive لفتاة في
+
+358
+00:26:49,890 --> 00:26:53,670
+الثامن عشر من عمرهاكانوا مسافروا على كندا وفي
+
+359
+00:26:53,670 --> 00:26:58,450
+الإجراءات .. في إجراءات لازم نعمل testing ..
+
+360
+00:26:58,450 --> 00:27:01,750
+testing للأشخاص اللي جابوا ياخدوا ال visa لمجموعة
+
+361
+00:27:01,750 --> 00:27:05,390
+من الأعمار ومنها ال syphilis تمام؟ فطلع من دون أن
+
+362
+00:27:05,390 --> 00:27:10,260
+عن العائلة تبعتها كلها طلعت بوسترفلمّا جابولي
+
+363
+00:27:10,260 --> 00:27:13,860
+الأمضاء التقارير فبقولهم أنتوا عملتوا confirmation
+
+364
+00:27:13,860 --> 00:27:18,000
+جانوا لأ طب قلتله ماعرفينش يعني تعطي نتيجة لأنثى
+
+365
+00:27:18,000 --> 00:27:20,420
+في قطاع غزة أو تكون syphilis positive ماعرفينش
+
+366
+00:27:20,420 --> 00:27:24,160
+يعني يعني ماتروحش على البيت ممكن تقتل صح ولا مش صح
+
+367
+00:27:24,160 --> 00:27:27,560
+فأبقينا
+
+368
+00:27:27,560 --> 00:27:31,800
+نتيجة أخرنا ظهور نتيجة لعبارة عن ما عملنا
+
+369
+00:27:31,800 --> 00:27:34,420
+confirmatory test فقلتله الفحص negative فحص
+
+370
+00:27:34,420 --> 00:27:38,660
+negative في في دايما في في ال ..في ال screening
+
+371
+00:27:38,660 --> 00:27:44,360
+test بيكون فيها اسمها non specific results وإلا
+
+372
+00:27:44,360 --> 00:27:48,300
+كان ماضطراش نعمل confirmation إذا ال negative
+
+373
+00:27:48,300 --> 00:27:50,400
+negative بس ال positive لازم نعمله ايه
+
+374
+00:27:50,400 --> 00:27:54,100
+confirmation فنرجوا منكم الموقف اللي ذكرته هذا
+
+375
+00:27:54,100 --> 00:27:58,940
+ناخده على سبيل الإبرة و المواضع في التأني و
+
+376
+00:27:58,940 --> 00:28:03,940
+التفكير قبل إصدار بعض النتائج في تحليل الطبيب
+
+377
+00:28:08,410 --> 00:28:12,950
+Okay PCR assay can detect the presence of HTLV RNA
+
+378
+00:28:12,950 --> 00:28:17,150
+or DNA within infected cells يعني ممكن لو أخدنا ال
+
+379
+00:28:17,150 --> 00:28:20,350
+buffer coat layer من الدم تبقى المريض و أخدنا ال
+
+380
+00:28:20,350 --> 00:28:23,870
+white blood cell نعمل extraction لل DNA أو ال RNA
+
+381
+00:28:23,870 --> 00:28:27,950
+و نقدر نكشف عن اللي هو الفيروس ال test used to
+
+382
+00:28:27,950 --> 00:28:31,010
+screen the red blood contains only هذه المعلومة
+
+383
+00:28:31,010 --> 00:28:38,070
+منيها أنا بكشفعن ال blood bag باكشف عن antibodies
+
+384
+00:28:38,070 --> 00:28:44,130
+لمين؟ لل HTLV-1 طب و ال HTLV-2 طب ما هو بتاني
+
+385
+00:28:44,130 --> 00:28:48,850
+بيسبب نفس الأمراض قبل قليل وإن كان وإن كان الدلائل
+
+386
+00:28:48,850 --> 00:28:53,570
+مش مؤكدة إن هو اللي بيسبب لكن المعلم بفترض إن هو
+
+387
+00:28:53,570 --> 00:28:56,790
+اللي بيسبب وبتاني لازم نبحث عنه هبقول إن أنا
+
+388
+00:28:56,790 --> 00:29:01,210
+بستخدم antigen ل HTLV-1 لكن هذا ال antigen اللي
+
+389
+00:29:01,210 --> 00:29:06,690
+حصل حظنا كان cross react withاللي هو HTLV-2 فقد
+
+390
+00:29:06,690 --> 00:29:12,410
+اكشف انا HTLV-2 او HTLV-1 وانا مش عارف من هما لكن
+
+391
+00:29:12,410 --> 00:29:17,230
+positive لأي من هما لكن للأسف هذا الفحص ايضا في
+
+392
+00:29:17,230 --> 00:29:22,110
+بعض العيوب انه بيفقد بعض ال HTLV-2 اذا بعض الحالات
+
+393
+00:29:22,110 --> 00:29:27,530
+قد يفقدها اذا الفحص تبعنا هنا مش sensitive للتنين
+
+394
+00:29:27,530 --> 00:29:31,310
+وانما sensitive لمن لل HTLV-1 فقط
+
+395
+00:29:35,650 --> 00:29:39,850
+ال isolation لل HTLV in cell culture is not done و
+
+396
+00:29:39,850 --> 00:29:43,930
+السبب المفروض أنكم تكونوا فاهمته الآن لأنه
+
+397
+00:29:43,930 --> 00:29:47,790
+مابتكثرش تكاثر طبيعي في الخلايا و انما بيعمل
+
+398
+00:29:47,790 --> 00:29:52,320
+transformation بيعمل transformationATL is
+
+399
+00:29:52,320 --> 00:29:55,380
+diagnosed by finding malignant T-cells in the
+
+400
+00:29:55,380 --> 00:29:58,440
+lesions يعني لو شوفنا خلايا سلطانية في الـ lesions
+
+401
+00:29:58,440 --> 00:30:02,680
+الشكل اللي احنا شوفناه قبل قليل، هذا مميز إلينا
+
+402
+00:30:02,680 --> 00:30:05,280
+الـdiagnosis of HAM is supported by the presence
+
+403
+00:30:05,280 --> 00:30:08,760
+of HTLV antibodies in the spinal fluid يعني إذا
+
+404
+00:30:08,760 --> 00:30:13,380
+بناخد عينات من وين؟ من الـCSF أو finding HTLV
+
+405
+00:30:13,380 --> 00:30:17,430
+nucleic acid in cells in the spinal fluidأيش كيف
+
+406
+00:30:17,430 --> 00:30:22,950
+نجد الـ Nucleic Acid من خلال الـ PCR اللي حكينا
+
+407
+00:30:22,950 --> 00:30:28,710
+عنه قبل قليل ال treatment and prevention there is
+
+408
+00:30:28,710 --> 00:30:32,310
+no specific antiviral treatment of HTLV infection
+
+409
+00:30:32,310 --> 00:30:36,310
+and no antiviral drugs يعني لا إله vaccine ولا إله
+
+410
+00:30:36,310 --> 00:30:39,330
+antiviral
+
+411
+00:30:39,330 --> 00:30:43,610
+drug will cure latent infection by HTLV خاصة أنه
+
+412
+00:30:43,610 --> 00:30:45,750
+احنا بنتكلم عن latent infection و هذا الكلام
+
+413
+00:30:46,190 --> 00:30:49,790
+كررناها زمان لما قلنا لكوا انه حتى بقى Cyclovere
+
+414
+00:30:49,790 --> 00:30:52,470
+اللي كنا بنستخدمه لل .. لل .. لل .. ال herpes
+
+415
+00:30:52,470 --> 00:30:56,190
+simplex type 1 و type 2 و لـ ال .. ال CMV okay
+
+416
+00:30:56,190 --> 00:31:00,310
+ممكن يخفف من الأعراض ممكن يشيلي ال virus اللي ..
+
+417
+00:31:00,310 --> 00:31:02,790
+اللي عامل ال infection الآن لكن ولا بأي حال من
+
+418
+00:31:02,790 --> 00:31:06,830
+الأحوال يستطيع ان يتخلص من ال tendency تبع ال
+
+419
+00:31:06,830 --> 00:31:12,050
+virus ATL is treated with anticancer chemotherapy
+
+420
+00:31:12,050 --> 00:31:14,910
+regimen يعني بعمله كأنه cancer و انتهى الموضوع
+
+421
+00:31:15,590 --> 00:31:18,150
+Antiviral drugs have not been effective in the
+
+422
+00:31:18,150 --> 00:31:23,310
+treatment of ham, corticosteroid and denasol have
+
+423
+00:31:23,310 --> 00:31:27,010
+produced improvement in some patients يعني عملوا
+
+424
+00:31:27,010 --> 00:31:31,310
+خلطة بين ال corticosteroid و ال denasol و أعطت بعض
+
+425
+00:31:31,310 --> 00:31:36,170
+التحسن في بعض المرضى لحظة كان مرة التواضع في لو
+
+426
+00:31:36,170 --> 00:31:41,410
+احنا اللي جينا حالة تحسنبنضخمها بس هنا لازم نكون
+
+427
+00:31:41,410 --> 00:31:45,570
+موضوعيين بالفعل و نقول انه النتائج تبعاتنا لم تعطي
+
+428
+00:31:45,570 --> 00:31:49,130
+تلك النتيجة للعالم there is no vaccine in H أو
+
+429
+00:31:49,130 --> 00:31:54,250
+against HTLV ال prevention strategies و احنا
+
+430
+00:31:54,250 --> 00:31:57,110
+قلنالكم انه كتير من الأمراض اللي يصعب علاجها
+
+431
+00:31:57,110 --> 00:32:04,110
+مائلنا الا غير انه نشوف الإجراءات المتبعة في عملية
+
+432
+00:32:04,110 --> 00:32:07,650
+اللي هو ال prevention و ال prevention على فكرة
+
+433
+00:32:07,650 --> 00:32:15,550
+يعنيإيه؟استراتيجية رايعة جدا وممكن احنا اللي كان
+
+434
+00:32:15,550 --> 00:32:17,890
+المفروض اليوم نعمل يوم دراسي عن ال infection
+
+435
+00:32:17,890 --> 00:32:21,270
+control وفي خضم الانشغال في اسبوع المضاد الحيوية
+
+436
+00:32:21,270 --> 00:32:25,370
+نسينا الموضوع خالص وما .. ماتبنروش فاحتمال يعني
+
+437
+00:32:25,370 --> 00:32:27,250
+على .. على نهاية الامتحانات تبعتكم ان شاء الله
+
+438
+00:32:27,250 --> 00:32:30,790
+نعمل يوم دراسي عن ال infection control ودوره
+
+439
+00:32:30,790 --> 00:32:33,990
+وادواته ويعني أشياء متعلقة بال infection control
+
+440
+00:32:33,990 --> 00:32:36,910
+فان شاء الله إذا كان في نصيب يعني تحضر هذا اليوم
+
+441
+00:32:36,910 --> 00:32:39,090
+الدراسي بيكون استفدت ان شاء الله .. ان شاء الله
+
+442
+00:32:39,090 --> 00:32:44,270
+كويسفبنقول إن ال infection control إلها آثار
+
+443
+00:32:44,270 --> 00:32:48,590
+إيجابية في منع الأمراض الموادية بشكل كبير و يجب أن
+
+444
+00:32:48,590 --> 00:32:52,010
+لا نستهين بها، و خاصة في الأمراض التي لا يمكن
+
+445
+00:32:52,010 --> 00:32:57,510
+علاجها بطريقة سهلة و معسرةscreening donated blood
+
+446
+00:32:57,510 --> 00:33:00,310
+for the presence of antibodies هذي أثبتت فعالية
+
+447
+00:33:00,310 --> 00:33:04,850
+كويسة لمنع اللي هو انتقال المرض عبر ل blood
+
+448
+00:33:04,850 --> 00:33:08,070
+transfusion يا هل طبعا ال blood transfusion هل هو
+
+449
+00:33:08,070 --> 00:33:12,150
+حجمه كبير كتير في الدنيا عشان نهتم فيه لها درجة
+
+450
+00:33:12,150 --> 00:33:16,380
+هذي؟ نعماسألوا بنك الدم في أي مستشفى من المستشفات،
+
+451
+00:33:16,380 --> 00:33:19,960
+قولوا حجم التبادل في الدم عندكم من جداش، بيقولوا
+
+452
+00:33:19,960 --> 00:33:22,960
+إن نسبه عالية جدا، الآن العملية الجراحية لازم يكون
+
+453
+00:33:22,960 --> 00:33:28,740
+في blood، يعني احتياط في هذه العمليةUsing condoms
+
+454
+00:33:28,740 --> 00:33:31,800
+to prevent sexual transmission يعني احتياطات او
+
+455
+00:33:31,800 --> 00:33:35,340
+الجنس الأمن يسموها Encouraging women with HTLV
+
+456
+00:33:35,340 --> 00:33:38,420
+antibodies to refrain from breastfeeding يعني لو
+
+457
+00:33:38,420 --> 00:33:43,920
+كانت أم صابة أو عندها antibodies لهذا الفيروس انه
+
+458
+00:33:43,920 --> 00:33:46,540
+تمتنع عن الرضاعة الطبيعية وتستبدلها بالرضاعة
+
+459
+00:33:46,540 --> 00:33:50,680
+الصينعية هيك بينقول احنا انتهينا من مجموعة اسمها
+
+460
+00:33:50,680 --> 00:33:57,560
+RNA Enveloped Virus طبعاإذا لاحظته إن الـHIV
+
+461
+00:33:57,560 --> 00:34:02,060
+المفروض يكون من ضمن المجموعة، بس مدرس نهوش، وبتالي
+
+462
+00:34:02,060 --> 00:34:05,360
+هذا أكيد إله ماله، إله وضع خاص، فبتالي إن شاء الله
+
+463
+00:34:05,360 --> 00:34:07,700
+هنطلع عليه بشكل منفصل بإذن الله
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b4f1f91a17f7ebec640d63be3ff8da97caddf533
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU.srt
@@ -0,0 +1,2255 @@
+1
+00:00:20,810 --> 00:00:23,430
+بسم الله الرحمن الرحيم، نكمل إن شاء الله ما بدأنا
+
+2
+00:00:23,430 --> 00:00:27,850
+المحاضرة السابقة في الـ DNA viruses ومازلنا وسنبقى 
+
+3
+00:00:27,850 --> 00:00:31,990
+إن شاء الله لمحاضرتين قادمتين في الـ herpes viruses
+
+4
+00:00:31,990 --> 00:00:35,810
+والـ herpes viruses جونا مجموعة مكونة من ستة أفراد
+
+5
+00:00:35,810 --> 00:00:38,850
+على الأقل: herpes simplex type 1, herpes simplex
+
+6
+00:00:38,850 --> 00:00:42,670
+type 2, varicella zoster, cytomegalovirus,
+
+7
+00:00:43,010 --> 00:00:46,730
+Epstein-Barr virus، وتحدثنا في الأخير على اللي
+
+8
+00:00:46,730 --> 00:00:52,090
+هو الـ human herpes virus type 8، نقشنا بعض الـ .. الـ
+
+9
+00:00:52,090 --> 00:00:54,810
+.. الـ general characteristics لهذه المجموعة، وشوفنا
+
+10
+00:00:54,810 --> 00:00:59,090
+أنه هي unique in many ways، مثلا بأن هي الوحيدة
+
+11
+00:00:59,090 --> 00:01:00,890
+اللي بتاخد الـ envelope تبعها من الـ nuclear
+
+12
+00:01:00,890 --> 00:01:04,470
+membrane، هي من الميكروبات اللي .. اللي لها القدرة
+
+13
+00:01:04,470 --> 00:01:08,690
+على الـ latency، وهذه القدرة أكسبتها يعني مهارات
+
+14
+00:01:08,690 --> 00:01:14,360
+عديدة، وانت تخيلوا أنه أكثر من تسعين بالمائة، يمكن
+
+15
+00:01:14,360 --> 00:01:16,860
+مائة بالمائة من كوكب الأرض مصاب بأحد هذه
+
+16
+00:01:16,860 --> 00:01:19,440
+الفيروسات، يا إما بـ Herpes Simplex Type 1، يا إما
+
+17
+00:01:19,440 --> 00:01:22,720
+بـ Epstein-Barr Virus، يا إما بـ Cytomegalovirus،
+
+18
+00:01:22,720 --> 00:01:26,060
+لأنه .. هنشوف كمان شوية، لو تسعين بالمائة مثلا من
+
+19
+00:01:26,060 --> 00:01:28,740
+السكان في الولايات المتحدة عندهم Epstein-Barr
+
+20
+00:01:28,740 --> 00:01:33,170
+Virus، ثمانين بالمية عندهم Cytomegalovirus بشكل عام
+
+21
+00:01:33,170 --> 00:01:37,590
+عندهم أيضا حوالي 80% من herpes simplex type 1، وفيه
+
+22
+00:01:37,590 --> 00:01:40,410
+زيادة في herpes simplex type 2، إذا من الفيروسات
+
+23
+00:01:40,410 --> 00:01:45,230
+الشائعة والشهيرة والمنتشرة، وصلنا على الـ clinical
+
+24
+00:01:45,230 --> 00:01:51,300
+findings، وهي لوحة مكررة لكن ملخصة نوعا ما إلى ما
+
+25
+00:01:51,300 --> 00:01:56,300
+ذكرناه في السابق، أن جنجفوستيميتيتس، Herpes
+
+26
+00:01:56,300 --> 00:02:00,320
+Labialis، Keratoconjectivitis، Encephalitis،
+
+27
+00:02:00,320 --> 00:02:03,480
+Herpetic Whitlow و Herpes Gladiatorum، والتنتين
+
+28
+00:02:03,480 --> 00:02:07,620
+الأخرانيات هدولة هم إصابات للـ Herpes في أصابع أو
+
+29
+00:02:07,620 --> 00:02:11,720
+في أطراف الأيدي، طبعا هنتكلم يا عمينا عن Herpes
+
+30
+00:02:11,720 --> 00:02:17,000
+Simplex Type 1، هذه الأمراض بتصيبه ممكن عند الـ very
+
+31
+00:02:17,000 --> 00:02:20,340
+very immunocompromised patients، يصير فيه حادث
+
+32
+00:02:20,340 --> 00:02:26,000
+إسفاجيتس وممكن كمان نيومونيا، وفي الحالتين it is a
+
+33
+00:02:26,000 --> 00:02:28,660
+devastating disease، نيومونيتس due to Herpes
+
+34
+00:02:28,660 --> 00:02:33,840
+Simplex Type 1، بتكون مدمرة للغاية، الـ Clinical
+
+35
+00:02:33,840 --> 00:02:37,560
+findings لـ Herpes Simplex Type 2، أن جينة الهيربز،
+
+36
+00:02:37,560 --> 00:02:39,840
+نيوناتا الهيربز بالإضافة إلى الـ Aseptic
+
+37
+00:02:39,840 --> 00:02:43,060
+Meningitis، وأعتقد أنه طرحنا لمصطلح Aseptic
+
+38
+00:02:43,060 --> 00:02:48,580
+Meningitis، أنه يعني الكائن المسبب غير موجود أو لا
+
+39
+00:02:48,580 --> 00:02:52,460
+يمكن عزله بالـ Regular Techniques في الـ lab
+
+40
+00:02:52,460 --> 00:02:56,400
+diagnosis، عزل الفيروس في الـ cell culture يعتبر
+
+41
+00:02:56,400 --> 00:03:00,920
+واحدة من أهم الطرق المستخدمة في تشخيص هذا الفيروس
+
+42
+00:03:00,920 --> 00:03:06,400
+بالإضافة إلى طبعا تعرفين لما كنا نعزل البكتيريا على
+
+43
+00:03:06,400 --> 00:03:10,300
+الأطباق المكونكي والـ blood agar، كنا نكاثرها ونـ
+
+44
+00:03:10,300 --> 00:03:14,160
+شوف مستعمرات مظبوط، لكن هذه المستعمرات ولا بأي حال
+
+45
+00:03:14,160 --> 00:03:19,960
+من الأحوال كانت هي المشخصة لنوع البكتيريا، فكذلك
+
+46
+00:03:19,960 --> 00:03:23,300
+الأمر بالنسبة لمزرعة الفيروسات، نحن نزرع الفيروسات
+
+47
+00:03:23,300 --> 00:03:27,920
+على الـ cell culture ثم نقوم بإجراء فحوصات على الـ
+
+48
+00:03:27,920 --> 00:03:30,140
+large number اللي صار عندنا من الفيروسات في الـ
+
+49
+00:03:30,140 --> 00:03:35,200
+cell culture، قد تساعدنا بعض الأحيان أنه الـ virus
+
+50
+00:03:35,200 --> 00:03:38,460
+بيعمل cytopathic effect، وأظن الـ herpes virus
+
+51
+00:03:38,460 --> 00:03:40,640
+بتعمل cytopathic effect، إيش هو cytopathic effect
+
+52
+00:03:40,640 --> 00:03:46,140
+اللي هو الـ cytomegalo أو الـ giant cell formation
+
+53
+00:03:46,140 --> 00:03:50,280
+هذا كان أحد الـ الـ الـ خدنا نقول الـ hallmarks للـ
+
+54
+00:03:50,280 --> 00:03:54,660
+herpes viruses، وكلمة cytomegalovirus أصلا CMV
+
+55
+00:03:54,660 --> 00:04:01,630
+معناها الفيروس المضخم للخلايا، الـ cytopathic effect
+
+56
+00:04:01,630 --> 00:04:05,690
+بحث بيكون كثير مميز على اللي هو cell culture
+
+57
+00:04:05,690 --> 00:04:09,970
+والجميل في هذا الموضوع أنه قد يظهر الـ cytopathic
+
+58
+00:04:09,970 --> 00:04:13,730
+effect في يوم إلى ثلاث أيام من الزراعة، يعني وقت
+
+59
+00:04:13,730 --> 00:04:19,830
+قصير بالنسبة لزراعة الفيروسة، لكن قد نحتاج إلى
+
+60
+00:04:19,830 --> 00:04:25,430
+تقنيات منعية زي الـ ELISA للكشف عن الـ antigen في
+
+61
+00:04:25,430 --> 00:04:27,930
+حاجة ما اتزنق سمير حكينا عنها المرة الماضية، كنا
+
+62
+00:04:27,930 --> 00:04:32,190
+أنه بناخد سواب من قاع اللي هو الـ lesion سواء كان
+
+63
+00:04:32,190 --> 00:04:36,830
+Herpes Simplex Type I أو Herpes Simplex Type II ونـ
+
+64
+00:04:36,830 --> 00:04:39,590
+نعمله Giemsa Staining ونشوف الـ Multinucleated
+
+65
+00:04:39,590 --> 00:04:41,790
+Giant Cell أيضا في هذا السمير
+
+66
+00:04:45,640 --> 00:04:49,000
+ممكن أيضا كمان نكشف عن الـ .. الـ .. الـ herpes
+
+67
+00:04:49,000 --> 00:04:52,200
+viruses سواء type 1 و type 2 من خلال اللي هو الـ
+
+68
+00:04:52,200 --> 00:04:55,980
+PCR، يعني نكشف عن الـ DNA من خلال اللي هو الـ PCR
+
+69
+00:04:55,980 --> 00:04:59,660
+culture
+
+70
+00:04:59,660 --> 00:05:05,480
+زاد PCR بمشي بمشي الحال كمان، ومن الـ culture نعمل
+
+71
+00:05:05,480 --> 00:05:11,580
+PCR، يعني بمعنى آخر أنا أخد عينة وأعملها culture ومن
+
+72
+00:05:11,580 --> 00:05:15,260
+الـ culture أعمل الـ PCR، هذا طبعا بيزيد الـ
+
+73
+00:05:15,260 --> 00:05:19,910
+sensitivity تبعات الـ PCR، في كمان حاجة اسمها الـ
+
+74
+00:05:19,910 --> 00:05:23,810
+neutralization test، وكلمة الـ neutralization test
+
+75
+00:05:23,810 --> 00:05:28,930
+معناها أن الـ antibody اللي عند المريض يستخدم
+
+76
+00:05:28,930 --> 00:05:33,990
+لإيقاف تأثير الفيروس، أنا عندي فيروس مشهور اسمه
+
+77
+00:05:33,990 --> 00:05:38,070
+herpes simplex type 1، وأنا شاكر أن المريض عنده
+
+78
+00:05:38,070 --> 00:05:42,350
+antibodies للـ herpes simplex type 1، تمام؟ ناخد الـ
+
+79
+00:05:42,350 --> 00:05:47,560
+serum تبعه، وبنخلط الـ serum مع الفيروس وبنحطهم
+
+80
+00:05:47,560 --> 00:05:52,680
+اتنين على سلك culture، إذا توقف عن صناعة
+
+81
+00:05:52,680 --> 00:05:56,420
+الـ cytopathic effect، باه مين اللي وجفه؟ الـ
+
+82
+00:05:56,420 --> 00:05:59,880
+antibody، لو موجودين في السيرة بيبقى بقدر أكشف عن
+
+83
+00:05:59,880 --> 00:06:03,620
+موجود antibody من خلال neutralization test، مرة
+
+84
+00:06:03,620 --> 00:06:09,180
+أخرى بيقول إنه الآن الفيروس أنا عندي كـ agent في
+
+85
+00:06:09,180 --> 00:06:12,940
+المختبر، لو زرعته أنا من عندي في المختبر، لو زرعته
+
+86
+00:06:12,940 --> 00:06:16,080
+على سلك culture هيعطيني cytopathic effect، لو أخدت
+
+87
+00:06:16,080 --> 00:06:20,500
+من الـ patient سيرام وحطيته على الـ cell culture و
+
+88
+00:06:20,500 --> 00:06:24,840
+توقف الفيروس عن صناع الـ cytopathic effect، ما الذي
+
+89
+00:06:24,840 --> 00:06:29,000
+أوقفه هو الـ antibodies اللي موجودة في السيرام، و
+
+90
+00:06:29,000 --> 00:06:32,320
+بما أنه أوقف الفيروس وهي specific له، فنقدر نقول
+
+91
+00:06:32,320 --> 00:06:35,800
+إن الإنسان عنده antibodies لهذا الفيروس
+
+92
+00:06:39,060 --> 00:06:42,640
+طبعا أن احنا معرفة الـ antibody وزيادتها في الدسم
+
+93
+00:06:42,640 --> 00:06:45,980
+بتساعدنا في تشخيص لـ primary infection، لكن ما
+
+94
+00:06:45,980 --> 00:06:48,900
+بتساعدنا في تشخيص من الـ reactivation، لأن already
+
+95
+00:06:48,900 --> 00:06:54,000
+الـ antibodies موجودة وبشكل مستمر، بالنسبة للعلاج
+
+96
+00:06:54,000 --> 00:06:58,440
+أشهر علاج مر علينا في الفيروسات احنا لحد الآن
+
+97
+00:06:58,440 --> 00:07:04,280
+اللي هو الـ acyclovir، وهو عبارة عن نوكليوتايد analog
+
+98
+00:07:04,280 --> 00:07:08,480
+وإيش يعني نوكليوتايد analog؟ يعني شبيه بالقواعد
+
+99
+00:07:08,480 --> 00:07:12,600
+النيتروجينية تبع الـ DNA، إيش القواعد النيتروجينية؟
+
+100
+00:07:12,600 --> 00:07:17,320
+أدينين، جوانين، سايتوسين وثيامين، مظبوط؟ ثيامين
+
+101
+00:07:17,320 --> 00:07:24,260
+اللي هم الـ C,G والـ A,T، الآن الـ DNA polymerase يفترض
+
+102
+00:07:24,260 --> 00:07:27,980
+لما بيعمل replication للـ DNA بياخد القاعدة وبصفها
+
+103
+00:07:27,980 --> 00:07:32,420
+على جبال القاعدة، قاعدة على جبال القاعدة، الآن لو لجأ في
+
+104
+00:07:32,420 --> 00:07:37,720
+طريقة نوكليوتايد Analog، Analog يعني شبيه، هياخدها
+
+105
+00:07:37,720 --> 00:07:39,920
+مش هيقدر تميز بين الـ nucleotide وبين الـ
+
+106
+00:07:39,920 --> 00:07:43,760
+nucleotide Analog، بياخدها وبركبها على الشريط
+
+107
+00:07:43,760 --> 00:07:50,460
+بتركب المشكلة، بيبقى اللي مابدوش يكمل أي نوكليوتايد
+
+108
+00:07:50,460 --> 00:07:54,160
+جديدة مابتركبش مع الـ nucleotide Analog اللي جابلها
+
+109
+00:07:54,160 --> 00:07:58,980
+وبالتالي سيتوقف تصنيع مين؟ الـ DNA، إذا الـ
+
+110
+00:07:58,980 --> 00:08:02,140
+Nucleotide Analogue أو الـ Nucleoside Analogue هي
+
+111
+00:08:02,140 --> 00:08:06,720
+وسيلة لخداع الـ DNA أو الـ RNA Polymerase، وبالتالي
+
+112
+00:08:06,720 --> 00:08:10,940
+إيقاف تصنيع إما الـ DNA أو الـ RNA، وهذه وسيلة
+
+113
+00:08:10,940 --> 00:08:14,720
+الحقيقة مستخدمة في علاج الفيروسات ومستخدمة أيضا في
+
+114
+00:08:14,720 --> 00:08:17,580
+علاج السرطانات، Nucleotide Analogues
+
+115
+00:08:20,210 --> 00:08:23,430
+قلنا لكوا الـ acyclovir، الـ acyclovir مشهور في هذا
+
+116
+00:08:23,430 --> 00:08:26,690
+الموضوع، وممكن أشهر اسم تجاري اللي اسمه Zovirax
+
+117
+00:08:26,690 --> 00:08:30,890
+Zovirax هو عبارة عن برهام، أصبع برهام صغير و
+
+118
+00:08:30,890 --> 00:08:37,830
+تكلفته عالية وكفاءته ليست يعني بالقدر المتوقع، إذا
+
+119
+00:08:37,830 --> 00:08:41,630
+ظهر الـ blister اللي هي اللي قلنا عنها الـ physical
+
+120
+00:08:41,630 --> 00:08:49,370
+تمام، إذا ظهرت فليس له أي فايدة، ليش؟ لأنه already الـ
+
+121
+00:08:49,370 --> 00:08:54,610
+virus تكاثر ووصل لمرحلة تبعه الـ maximum وهو أصلا
+
+122
+00:08:54,610 --> 00:08:59,250
+بدأ بالانحصار بشكل طبيعي من المناعة الموجودة في
+
+123
+00:08:59,250 --> 00:09:05,830
+جسم الإنسان، لكن عند بداية الظهور أو إذا كان جهاز
+
+124
+00:09:05,830 --> 00:09:09,720
+المناعة تبع الإنسان ضعيف جدا، الأسيكلوفير قد يساعد
+
+125
+00:09:09,720 --> 00:09:12,880
+وانقروا إلى الجملة إيش بتقول الجملة هنا، it 
+
+126
+00:09:12,880 --> 00:09:16,020
+shortens the duration إيش يعني shorten the 
+
+127
+00:09:16,020 --> 00:09:21,240
+duration بتقصر الفترة الزمنية بدل ما هي أسبوع بتصير 
+
+128
+00:09:21,240 --> 00:09:27,090
+أربعة أيام مثلا؟ بتقصر إذا الـ duration ممكن تعمل
+
+129
+00:09:27,090 --> 00:09:34,490
+تقليل من عملية إفراز الفيروس، يعني يكون أقل 
+
+130
+00:09:34,490 --> 00:09:41,150
+مُوادياً، الإنسان ما يكون أيش مواد بشكل كبير، هذا مين 
+
+131
+00:09:41,150 --> 00:09:47,380
+الـ acyclovir؟ يبقى الـ acyclovir من مزايا أنه بيقصر
+
+132
+00:09:47,380 --> 00:09:54,180
+فترة المرض و بيقلل من كمية إفراز الفيروس لكن للأسف
+
+133
+00:09:54,180 --> 00:10:01,480
+حتى الفيروسات كما البكتيريا كما خلايانا لما بتعاند
+
+134
+00:10:01,480 --> 00:10:06,180
+علاجات السرطانات يعني بتصير resistant فالفيروسات
+
+135
+00:10:06,180 --> 00:10:10,740
+أيضاً لديها المقدرة لتعمل resistant للـ اللي هو الـ
+
+136
+00:10:10,740 --> 00:10:17,310
+antivirals ويمكن الـ Herpes Simplex Type I و Type II 
+
+137
+00:10:17,310 --> 00:10:21,790
+و Varicella Zoster، الثلاث الأولى هدول هم أقل
+
+138
+00:10:21,790 --> 00:10:28,530
+المجموعة مقاومة للـ acyclovir لكن عندنا الـ CMV على 
+
+139
+00:10:28,530 --> 00:10:31,370
+سبيل المثال الـ Cytomegalovirus هذا مقاوم 
+
+140
+00:10:31,370 --> 00:10:36,770
+للـ acyclovir بشكل كبير جداً، إذن بدنا نعرف إنه حتى
+
+141
+00:10:36,770 --> 00:10:39,930
+قدرة الفيروسات على المقاومة تختلف من فيروس إلى 
+
+142
+00:10:39,930 --> 00:10:46,760
+فيروس كما البكتيريا بالضبط في حال إنه وجهتنا حالة 
+
+143
+00:10:46,760 --> 00:10:51,560
+من acyclovir-resistant HSV اللي هو Herpes Simplex 
+
+144
+00:10:51,560 --> 00:10:56,380
+Virus ممكن نستخدم another drug اسمه Foscarnet 
+
+145
+00:11:01,550 --> 00:11:05,690
+احنا قلنا قبل المحاضرة الماضية أنه herpes simplex 
+
+146
+00:11:05,690 --> 00:11:09,810
+type 1 can cause keratitis مظبوط وقلنا لكوا الـ
+
+147
+00:11:09,810 --> 00:11:14,170
+keratitis في العين يعني العين عضو حساس وممكن يؤذي 
+
+148
+00:11:14,170 --> 00:11:17,990
+بشكل كبير وبتالي في مجموعة من العقاقير التي ممكن 
+
+149
+00:11:17,990 --> 00:11:24,250
+أن تستخدم مثل trifloridin و Peniciclovir فاكرين 
+
+150
+00:11:24,250 --> 00:11:29,810
+البنسلين البنسالين كان هو الـ natural molecule أول
+
+151
+00:11:29,810 --> 00:11:34,450
+موليكيول من الـ antibiotics بعدين أخذوا علماء الـ
+
+152
+00:11:34,450 --> 00:11:38,810
+organic chemistry و بدوا يحوروا فيه ديفله chlorine 
+
+153
+00:11:38,810 --> 00:11:43,050
+ديفله fluor ديفله مش عارف group methyl وصار عندنا
+
+154
+00:11:43,050 --> 00:11:47,430
+مجموعة كبيرة من الـ antibiotics مشتقة أصلاً من مين؟
+
+155
+00:11:47,430 --> 00:11:51,590
+من الـ penicillin زي مثلاً الـ ambicillin زي الـ
+
+156
+00:11:51,590 --> 00:11:55,110
+amoxicillin دي الـ methicillin نافيسيلين كلها دي
+
+157
+00:11:55,110 --> 00:11:58,540
+مشتقات من مين؟ من الـ penicillin أيضاً الـ acyclovir 
+
+158
+00:11:58,540 --> 00:12:03,600
+كان مركب ومش طبيعي طبعاً، مركب لكن صار عليه 
+
+159
+00:12:03,600 --> 00:12:07,880
+تحويرات متنوعة ومختلفة، والحقيقة أن هذه التحويرات
+
+160
+00:12:07,880 --> 00:12:11,960
+أثبت بعض منها أنه أفضل من مين من الجزء الأم اللي 
+
+161
+00:12:11,960 --> 00:12:18,110
+هو الـ acyclovir، زي مثلاً بنسيكلوفير في كمان دوكاسينول
+
+162
+00:12:18,110 --> 00:12:23,490
+وهو عبارة عن long chain saturated alcohol وبيستخدم
+
+163
+00:12:23,490 --> 00:12:30,730
+لعلاج الـ herpes simplex type 1 في العين ما زلنا في
+
+164
+00:12:30,730 --> 00:12:34,590
+treatment و في الـ herpes simplex type 2 اللي هو الـ
+
+165
+00:12:34,590 --> 00:12:39,500
+genital herpes ممكن نستخدم valacyclovir و فام
+
+166
+00:12:39,500 --> 00:12:43,880
+سيكلوفير أو فام سيكلوفير تمام فام سيكلوفير و فالا
+
+167
+00:12:43,880 --> 00:12:47,540
+سايكلوفير تتضايقوش من الأسماء كتير لإنه في الآخر
+
+168
+00:12:47,540 --> 00:12:51,360
+كلهم سايكلوفير أضيفوا المقطع قطع الاسمين وإن شاء
+
+169
+00:12:51,360 --> 00:12:54,040
+الله هيكونوا سهلين بإذن الله كمان مرة فالا 
+
+170
+00:12:54,040 --> 00:12:59,460
+سايكلوفير و فام سيكلوفير كلاهما بيساعدوا على إنه
+
+171
+00:12:59,460 --> 00:13:02,280
+يعملوا suppression للـ recurrence of infection
+
+172
+00:13:02,280 --> 00:13:06,650
+عارفين شهية recurrence؟ يعني إعادة اللي هو الـ .. مش
+
+173
+00:13:06,650 --> 00:13:10,410
+هنقولنا latent infection وبعدين reactivation الـ
+
+174
+00:13:10,410 --> 00:13:15,750
+reactivation هو الـ recurrence نفسه الآن احنا ذكرنا
+
+175
+00:13:15,750 --> 00:13:20,130
+مجموعة من العقاقير ذكرنا Cyclovere ذكرنا Foscarnet
+
+176
+00:13:20,130 --> 00:13:25,990
+ذكرنا قبل قليل Velacyclovere و Valacyclovere و الـ
+
+177
+00:13:25,990 --> 00:13:29,650
+.. اللي جابلها كانت اللي هي الـ .. الـ trifluoridine
+
+178
+00:13:29,650 --> 00:13:34,790
+و البنسيكلوفير و الدوكاسينول واحد من هذه
+
+179
+00:13:34,790 --> 00:13:40,230
+العقاقير لديه المقدرة على أن يتعامل مع اللي تنسى
+
+180
+00:13:41,340 --> 00:13:46,660
+يعني احنا بنعالج الأعراض، بنعالج الفيروس اللي خارج
+
+181
+00:13:46,660 --> 00:13:52,860
+الخلايا، لكن ليس لدينا لحد الآن أي قدرة على إخراج
+
+182
+00:13:52,860 --> 00:13:57,000
+اللي تنسى اللي موجود في الخلايا، وأنا شرحت لكم
+
+183
+00:13:57,000 --> 00:14:01,120
+المرة الماضية كيف لهذه الفيروسات أن تبقى كامنة 
+
+184
+00:14:01,120 --> 00:14:06,580
+داخل الخلايا، مين بتذكر؟ السيتوبلازم اللي أنا
+
+185
+00:14:06,580 --> 00:14:10,140
+بقوله ده في السيتوبلازم طبعاً مش كلهم .. مش كلهم
+
+186
+00:14:10,140 --> 00:14:14,280
+بيشتغلوا نفس القاعدة لكن وجودهم في السيتوبلازم لو
+
+187
+00:14:14,280 --> 00:14:17,960
+جاءنا one copy .. one copy كان بنقول بسيطة إيه
+
+188
+00:14:17,960 --> 00:14:20,500
+بنضحك على جهاز الـ .. على الـ .. على الفيروس خلينا 
+
+189
+00:14:20,500 --> 00:14:24,040
+نعمل shutdown جهاز المناعة نطفي جهاز المناعة ونقول
+
+190
+00:14:24,040 --> 00:14:28,600
+للفيروسات اللي بقوله ده اطلعي تمام؟ ثمنعيد تشغيل
+
+191
+00:14:28,600 --> 00:14:32,220
+الجهاز المناعي، كان قاضينا على الفيروس، لكن غالباً
+
+192
+00:14:32,220 --> 00:14:35,900
+الفيروس بيكون داخل الخلايا in multiple copies،
+
+193
+00:14:35,900 --> 00:14:39,320
+يعني الـ DNA تبعه مش لنسخة واحدة، مجموعة، ولما يصير
+
+194
+00:14:39,320 --> 00:14:44,780
+reactivation جزء منها بيبقى يوصل الصورة بمعنى إنه
+
+195
+00:14:44,780 --> 00:14:49,280
+بيغامرش بكل الـ copies اللي موجودة فيه وأنا قبل
+
+196
+00:14:49,280 --> 00:14:52,980
+قليل بقول لكوا إنه 80% أو 90% من سكان العالم محتوى
+
+197
+00:14:52,980 --> 00:14:56,860
+على الفيروس يبدو إن احنا viruses بتمشي على الأرض
+
+198
+00:14:56,860 --> 00:15:02,500
+ولا ليش رأيكم؟ يعني عندنا CMV وعندنا Herpes
+
+199
+00:15:02,500 --> 00:15:08,480
+Simplex Type 1 وعندنا .. كمان معظمنا أصيب به الـ
+
+200
+00:15:08,480 --> 00:15:13,440
+chickenpox فالفيروس Zoster هيكون موجودة حتى
+
+201
+00:15:13,440 --> 00:15:16,880
+بالإضافة إلى فيروسات قد لا نعلم عنها شيئاً والحقيقة 
+
+202
+00:15:16,880 --> 00:15:19,360
+أن العلماء كشفوا أن جزء كبير من الجينوم تبقى
+
+203
+00:15:19,360 --> 00:15:25,100
+الإنسان هو عبارة عن الـ genome لفيروس يعني أو على 
+
+204
+00:15:25,100 --> 00:15:29,000
+الأقل بيشبه اللي هو الـ genome تبع فيروس فقد يكون
+
+205
+00:15:29,000 --> 00:15:34,120
+لها دور في أجسامنا ونحن لا ندري بعد وطبعاً أنا هقول 
+
+206
+00:15:34,120 --> 00:15:38,460
+دايماً إنه ما نغفلش ده دماغنا على إنه إيش دخل
+
+207
+00:15:38,460 --> 00:15:41,380
+الفيروسات فينا، إيش دخل البكتيريا فينا، هي نشوفنا
+
+208
+00:15:41,380 --> 00:15:45,600
+إن الـ human microbiome الـ human microbiome اللي هو
+
+209
+00:15:45,600 --> 00:15:48,620
+النبيت الميكروبي اللي مولود في أجسامنا، في أمعائنا
+
+210
+00:15:49,110 --> 00:15:53,190
+طلع له دور واعتبره العلماء كأنه عضو زيه زي الكبد
+
+211
+00:15:53,190 --> 00:15:57,550
+زيه زي الكلية اللي هو دور مهم جداً ويعتقد أن معظم 
+
+212
+00:15:57,550 --> 00:16:03,410
+الأمراض العصرية من الضغط والسكر والشرين والقلب ناتجة
+
+213
+00:16:03,410 --> 00:16:07,350
+عن الاعتلال اللي موجود في الـ normal microbiota فقد
+
+214
+00:16:07,350 --> 00:16:11,410
+يكون هناك أدوار محتملة للفيروسات في تكويننا ونحن
+
+215
+00:16:11,410 --> 00:16:18,480
+لا ندري بعد بقولنا اللي تنسى اللي لا يوجد إمكانية
+
+216
+00:16:18,480 --> 00:16:24,320
+للتخلص منه في الوقت الحاضر Prophylactic long term
+
+217
+00:16:24,320 --> 00:16:28,580
+administration of إيش معنى long term يعني لفترات 
+
+218
+00:16:28,580 --> 00:16:32,120
+ممتدة وطويلة acyclovere ولا acyclovere و
+
+219
+00:16:32,120 --> 00:16:35,680
+فامcyclovere can suppress clinical recurrences زي
+
+220
+00:16:35,680 --> 00:16:42,420
+ما ذكرنا قبل قليل الـ prevention involves avoiding
+
+221
+00:16:42,420 --> 00:16:47,140
+contact with vesicular lesions or ulcers طبعاً الـ
+
+222
+00:16:47,140 --> 00:16:51,420
+ulcer و الـ vesicular lesion هاتفقنا من المحاضرة
+
+223
+00:16:51,420 --> 00:16:56,480
+الماضية إنه مليء بالفيروس مليء بالفيروس إذا إذا
+
+224
+00:16:56,480 --> 00:17:02,040
+شفنا lesion تمام نبتعد عنها الآن المشكلة وين
+
+225
+00:17:02,040 --> 00:17:06,980
+المشكلة لو هالكلام صحيح كان نص الـ كان معظم الناس
+
+226
+00:17:06,980 --> 00:17:12,900
+ما أصيبتش لكن واضح أن الفيروس ينتقل حتى في عدم وجود
+
+227
+00:17:12,900 --> 00:17:17,700
+الـ lesion و الـ ulcer فموضوع الـ prevention في هذا 
+
+228
+00:17:17,700 --> 00:17:22,220
+الحالة شيء يعني يعتبر ضرب من الخيال لأن احنا ما
+
+229
+00:17:22,220 --> 00:17:26,460
+بنعرف الأشخاص اللي حاملين أو اللي بيفرزوا هذا
+
+230
+00:17:26,460 --> 00:17:32,780
+الفيروس الأمهات اللي عندهم genital herpes أو
+
+231
+00:17:32,780 --> 00:17:39,180
+herpes simplex type 2 و حوامل يمكن يعني تجنيب
+
+232
+00:17:39,180 --> 00:17:43,140
+المولود المرور عبر قناة الولادة من خلال عملية
+
+233
+00:17:43,140 --> 00:17:48,460
+قيصرية أو caesarean section الفيروس الثالث في
+
+234
+00:17:48,460 --> 00:17:51,640
+السلسلة اللي هو الـ Varicella zoster virus أيضاً من
+
+235
+00:17:51,640 --> 00:17:55,100
+الفيروسات الشهيرة والتي لها تأثيرات يعني
+
+236
+00:17:55,100 --> 00:17:57,040
+devastating على البشرية
+
+237
+00:17:59,270 --> 00:18:03,070
+لكم أن تتخيلوا أن هذا الفيروس .. هذا الفيروس كان
+
+238
+00:18:03,070 --> 00:18:07,950
+أكثر الفيروسات قبل 2001 من الفيروسات اللي بيسموها
+
+239
+00:18:07,950 --> 00:18:13,670
+notifiable diseases إيش يعني notifiable diseases؟
+
+240
+00:18:13,670 --> 00:18:17,050
+يجب الإبلاغ عنها .. يجب الإبلاغ عنها .. إيش يعني
+
+241
+00:18:17,050 --> 00:18:21,810
+يجب الإبلاغ عنها؟ الآن في فيروس مثلاً Hepatitis B 
+
+242
+00:18:21,810 --> 00:18:26,010
+أو C وفي Entamoeba histolytica وفي sore throat
+
+243
+00:18:26,010 --> 00:18:30,660
+اللي هو التهاب اللوزتين على سبيل المثال مين منهم بدنا 
+
+244
+00:18:30,660 --> 00:18:36,060
+نبلغ عنه للوزارة الصحة الفلسطينية عشان في آخر
+
+245
+00:18:36,060 --> 00:18:39,940
+السنة طلع التقرير تبعها واتبع 2016 طلع وأنا مش
+
+246
+00:18:39,940 --> 00:18:42,540
+عارف على أي مجموعة اتحطته والله على الـ essential
+
+247
+00:18:42,540 --> 00:18:45,260
+medical microbiology وانتوا أظنيني أدرجت فيه ولا لا
+
+248
+00:18:46,020 --> 00:18:49,440
+في الـ medical microbiology التقرير موجود تغير 2016 
+
+249
+00:18:49,440 --> 00:18:53,060
+و كويس إنكوا تطلعوا عليه تحفظوش شيء اطّلعوا عليه 
+
+250
+00:18:53,060 --> 00:18:56,800
+بس شوفوا من الأمراض اللي احنا بالفعل بندور عليها 
+
+251
+00:18:56,800 --> 00:19:00,560
+كلمة بندور عليها هي the notifiable في حاجة اسمها
+
+252
+00:19:00,560 --> 00:19:04,000
+nationally notifiable disease يعني على المستوى
+
+253
+00:19:04,000 --> 00:19:07,980
+المحلي القومي وفي حاجة اسمها internationally 
+
+254
+00:19:07,980 --> 00:19:13,660
+notifiable disease يعني مثلا طاعون مدغشقر حالة واحدة
+
+255
+00:19:13,660 --> 00:19:16,740
+صارت من الطعون في أي مكان في الدنيا لازم منظمة
+
+256
+00:19:16,740 --> 00:19:18,800
+الصحة العالمية تعرف عنه هذا اسمه internationally 
+
+257
+00:19:18,800 --> 00:19:24,200
+notifiable disease الآن ال chickenpox هو
+
+258
+00:19:24,200 --> 00:19:27,040
+notifiable disease يجب الإبلاغ عنه سواء محلي أو
+
+259
+00:19:27,040 --> 00:19:32,980
+دوليفكان هو قبل 2001 هو الأشهر على الإطلاق في
+
+260
+00:19:32,980 --> 00:19:35,960
+الولايات المتحدة الأمريكية بمعنى أنه هو الأكثر
+
+261
+00:19:35,960 --> 00:19:39,700
+عددا هو الأكثر عددا طب مش اللي اختلف بين 2001 و
+
+262
+00:19:39,700 --> 00:19:44,080
+بعد ذلك هو إدخال ال vaccine للخدمة إدخال ال
+
+263
+00:19:44,080 --> 00:19:48,380
+vaccine للخدمة ما زال ل chickenpox يحدث حتى في
+
+264
+00:19:48,380 --> 00:19:53,980
+وجود ال vaccine لكن أقل حدة أقل حدة المرض بيكون من
+
+265
+00:19:53,980 --> 00:20:00,500
+ما لو لم يكن هناك تطيين البدءبنفهم أول حاجة معلومة
+
+266
+00:20:00,500 --> 00:20:04,000
+مهمة جدا ان ال Varicella Zoster is only one virus
+
+267
+00:20:04,000 --> 00:20:08,660
+يعني صحيح هما two diseases لكن one virus ما يفكرش
+
+268
+00:20:08,660 --> 00:20:12,620
+انه الفيروس بيكون بشكل و بعدين بيصير بشكل تاني
+
+269
+00:20:12,620 --> 00:20:19,180
+الشكل هو هو لم يتغير لكن بيسبب two conditions ال
+
+270
+00:20:19,180 --> 00:20:22,640
+condition الأول هو ال chickenpox اللي بتعرفوه و ال
+
+271
+00:20:22,640 --> 00:20:26,700
+condition التاني اللي هو ال Zoster ليش اختلف الأول
+
+272
+00:20:26,700 --> 00:20:33,140
+عن التاني؟بدا نفسره من الآن و نقولكوا انه في
+
+273
+00:20:33,140 --> 00:20:35,460
+البداية في ال primary infection there is no
+
+274
+00:20:35,460 --> 00:20:39,600
+immunity against this disease و اتذكروا كويس
+
+275
+00:20:39,600 --> 00:20:43,960
+الكلام اللي بدي احكيه لأنه حيزننا بعد دقايق no
+
+276
+00:20:43,960 --> 00:20:48,140
+immunity في الأطفال غالبا فبالتالي بيصير rashes في
+
+277
+00:20:48,140 --> 00:20:54,760
+كل وين في كل الجسم في كل الجسم طيب ال zoster فقط
+
+278
+00:20:54,760 --> 00:20:58,770
+في منطقة محددةو المنطقة المحددة .. طبعا الحزام
+
+279
+00:20:58,770 --> 00:21:02,350
+بالعربي ما يسميه الحزام الناري حزام لإنه بيجي على
+
+280
+00:21:02,350 --> 00:21:06,410
+شكل منطقة يعني عاملة زي الحزام localized متموضعة
+
+281
+00:21:06,410 --> 00:21:10,430
+تمام؟ سواء كان في الوجه في الصدر أو في الكتف أو في
+
+282
+00:21:10,430 --> 00:21:14,410
+الظهر لإن اللي تنسي بيكون في العصب العصب بيكون
+
+283
+00:21:14,410 --> 00:21:19,910
+طويل عندما يستشعر الفيروس بضعف المناعة بيخرج .. وين
+
+284
+00:21:19,910 --> 00:21:25,990
+بده يخرج؟ بيخرج مقابل ال .. ال .. مين؟ العصب تبعه
+
+285
+00:21:27,170 --> 00:21:31,670
+بيخرج مقابل العصب وبيعمل infection هو سيحاول أن
+
+286
+00:21:31,670 --> 00:21:36,150
+يذهب إلى كل أنحاء الجسم لكن لإنه في antibodies
+
+287
+00:21:36,150 --> 00:21:40,930
+بتعمل neutralization من كل الجسم ففقط بيذهب في
+
+288
+00:21:40,930 --> 00:21:45,710
+المكان المقابل للعصب إذا اختلف الأمر لإنه إيش
+
+289
+00:21:45,710 --> 00:21:49,630
+قلنا؟ قلنا إنه كان فيه بالأول مافيش مناعة خالص و
+
+290
+00:21:49,630 --> 00:21:53,330
+بعدين في المرحلة التانية كان فيه مناعة فهو فقط عمل
+
+291
+00:21:53,330 --> 00:21:57,430
+localized infection طب في معلومة تانية قبل ما نبدأ
+
+292
+00:21:57,430 --> 00:22:01,830
+سرد المعلومات اللي موجودة في ال slides عندما يصاب
+
+293
+00:22:01,830 --> 00:22:06,310
+الطفل بتكون الإصابة طبعته خفيفة لكن لما بيصاب
+
+294
+00:22:06,310 --> 00:22:09,350
+الكبار حكينا فيها دي؟ حكينا فيها يا جماعة الحكي
+
+295
+00:22:09,350 --> 00:22:13,510
+مافيش داعي عنه مافيش داعي انه ان نكرر الكلام بس
+
+296
+00:22:13,510 --> 00:22:17,890
+هذه برضه قضية مهمة ان نعرف انه ال .. ال .. ال ..
+
+297
+00:22:18,620 --> 00:22:21,560
+الـ Immunopathogenesis اللي شرحناها سابقاً، إله
+
+298
+00:22:21,560 --> 00:22:26,700
+بالفعل تأثير كبير على الإسم، إذا single serotype،
+
+299
+00:22:26,700 --> 00:22:30,360
+similar to other viruses, to other herpes viruses،
+
+300
+00:22:30,360 --> 00:22:35,580
+antigenically distinct، متميز عن باقي المجموعة
+
+301
+00:22:40,140 --> 00:22:43,980
+بينتقل أيضًا عن طريق الـ Respiratory droplets وهو
+
+302
+00:22:43,980 --> 00:22:49,900
+عبارة عن مرض مؤدي جدًا كلمة contagious يعني مرض
+
+303
+00:22:49,900 --> 00:22:55,170
+مؤدي ومؤدي جدًاوهو من أمراض الطفولة يعني غالبا
+
+304
+00:22:55,170 --> 00:22:59,330
+بيحصل فيه الأطفال more than 90% of people in the
+
+305
+00:22:59,330 --> 00:23:02,110
+United States have antibodies by the age of 10
+
+306
+00:23:02,110 --> 00:23:06,890
+years عشر سنوات بيكون تسعين بالمئة من الناس عندهم
+
+307
+00:23:06,890 --> 00:23:11,690
+antibody دليل علاش على أنهم تعرضوا لهذا ال virus
+
+308
+00:23:11,690 --> 00:23:18,250
+رقم ضخم جدابريسيلا و cars worldwide عالميا تحدث مش
+
+309
+00:23:18,250 --> 00:23:22,490
+بس في الوقت المتحدة قبل ال 2001 زي ما ذكرنا كان ال
+
+310
+00:23:22,490 --> 00:23:25,090
+chickenpox هو اعلى ال notifiable disease في
+
+311
+00:23:25,090 --> 00:23:29,750
+الولايات المتحدة لكن الاستخدام الواسع ده ال
+
+312
+00:23:29,750 --> 00:23:32,410
+vaccine خفض من هذه الاعداد
+
+313
+00:23:36,230 --> 00:23:38,950
+كل ال physicals اللي موجودة سواء كان في ال chicken
+
+314
+00:23:38,950 --> 00:23:43,130
+box أو في الزوستر موجود فيها الفيروس، ال physicals
+
+315
+00:23:43,130 --> 00:23:45,390
+موجود فيها الفيروس و الفيروس في هذه الحالة بيكون
+
+316
+00:23:45,390 --> 00:23:49,070
+معضي جدا و أنا ذكرت كلمة contagious، contagious
+
+317
+00:23:49,070 --> 00:23:50,170
+معناها معض
+
+318
+00:23:53,480 --> 00:23:57,140
+أحد النقاط المهمة اللي لازم نبرزها في هذا الموضوع
+
+319
+00:23:57,140 --> 00:24:03,200
+هو عندما يحدث حالة varicella أو زوستر في المستشفى
+
+320
+00:24:03,200 --> 00:24:10,160
+تعتبر حالة emergency لل infection control لماذا؟
+
+321
+00:24:10,160 --> 00:24:12,940
+دايما و أبدا بيكونوا تعرفوا أن بيئة المستشفى بيبقى
+
+322
+00:24:12,940 --> 00:24:17,690
+متميزةمتفردة لماذا بيقى متميزة و متفردة؟ لأن
+
+323
+00:24:17,690 --> 00:24:22,670
+روادها غالبا من دول المناعة المنخفضة أصلا رايحين و
+
+324
+00:24:22,670 --> 00:24:28,190
+هم مرضى وبتالي جهاز المناعة تبعهم depressed فأي
+
+325
+00:24:28,190 --> 00:24:32,670
+وجود لأي شخص مصاب بالفارسيلا أو بالزوستر سواء كان
+
+326
+00:24:32,670 --> 00:24:37,970
+من العاملين أو من المرضى should be isolated طبعا ان
+
+327
+00:24:37,970 --> 00:24:41,070
+العاملين بيقولوا خد sick leave يعني خد إجازة مرضية
+
+328
+00:24:41,070 --> 00:24:47,190
+بينما إذا كان من المرضى يجب أن يعزل في غرفة خاصة
+
+329
+00:24:47,190 --> 00:24:52,470
+لإنه إذا لم يعزل سيسبب outbreak انتشار واسع فيه
+
+330
+00:24:52,470 --> 00:24:57,610
+لإنه كمرة ما المرضى المردين lower immunity وهذا
+
+331
+00:24:57,610 --> 00:24:59,610
+بيسبب انتشار واسع جدا
+
+332
+00:25:03,240 --> 00:25:07,900
+من أهم ال findings اللي هي ال multinucleated giant
+
+333
+00:25:07,900 --> 00:25:11,740
+cell و ال intra nuclear inclusions و بنالكوا انه
+
+334
+00:25:11,740 --> 00:25:15,340
+الفيروس بيعمل لتنسي في الدورسل روت جانجيليا و هذا
+
+335
+00:25:15,340 --> 00:25:19,320
+السبب اللي بيخليه لما يعمل زوستر يعمل في هذه
+
+336
+00:25:19,320 --> 00:25:23,920
+المناطق حاكينا هذا الكلام اللي هو انه during
+
+337
+00:25:23,920 --> 00:25:27,260
+latency الفيروس بيكون مولود في وين في الـcytoplasm
+
+338
+00:25:27,260 --> 00:25:34,190
+و مش موجود في ال nuclear أو في ال nucleus بالنسبة
+
+339
+00:25:34,190 --> 00:25:37,950
+للزوستر احنا ذكرنا الشكل تبعه هو عبارة عن physical
+
+340
+00:25:37,950 --> 00:25:42,150
+مصطفى فيه بشكل حزام لكن اما اتكلمنا عن القلم
+
+341
+00:25:42,150 --> 00:25:47,500
+المصاحب اللي هو اللغة العربيةكانت دقيقة في الوصف
+
+342
+00:25:47,500 --> 00:25:52,580
+الشكلي و في نفس الوجد كانت دقيقة في الوصف الحسي
+
+343
+00:25:52,580 --> 00:25:58,780
+لإن النار برضه ألم تمام فال ال ال ال physical اللي
+
+344
+00:25:58,780 --> 00:26:02,380
+بتظهر في ال virus اللي في ال exhaust بتكون مؤلمة
+
+345
+00:26:02,380 --> 00:26:06,300
+جدا و فيها burning sensation أو شعور بيه يعني ألم
+
+346
+00:26:06,300 --> 00:26:11,760
+شديد و قد يستمر هذا الألم إلى عدة أسابيع وقد يكون
+
+347
+00:26:11,760 --> 00:26:16,520
+Debilitating كلمة Debilitating يعني معيق بمعنى إنه لا
+
+348
+00:26:16,520 --> 00:26:20,940
+يستطيع الشخص أن يمارس حياته بشكل طبيعي خلال فترة
+
+349
+00:26:20,940 --> 00:26:26,180
+إصابته بيه اللي هو الزوستر إمكانية الإصابة
+
+350
+00:26:26,180 --> 00:26:30,740
+بالزوستر تزداد بازدياد العمر يعني كل ما الإنسان
+
+351
+00:26:30,740 --> 00:26:35,220
+كبر عشان هيك نطلع على ال vaccine اللي هنشوفه كمان
+
+352
+00:26:35,220 --> 00:26:38,740
+شوية هلاج إنه ال vaccine تبقى الزوستر يعطى فوق ال
+
+353
+00:26:38,740 --> 00:26:43,190
+60 وبدي من هال لما نسأل ال vaccine تفكروا ليش في
+
+354
+00:26:43,190 --> 00:26:47,990
+اتنين vaccines؟ واحد ل ال chicken box و واحد لمين؟
+
+355
+00:26:47,990 --> 00:26:53,810
+لل zoster ليش ماعملوا vaccine للتانين؟ الاصل ان هو
+
+356
+00:26:53,810 --> 00:27:03,510
+فيروس واحد صح؟ يعني عمل ايه؟ vaccine واحد ماعرفش
+
+357
+00:27:03,510 --> 00:27:04,130
+نسمع؟
+
+358
+00:27:08,400 --> 00:27:10,800
+نفس الجثة يعني، هو مش .. هو مش .. لن يتغير،
+
+359
+00:27:10,800 --> 00:27:20,140
+الفيروس لن يتغير هو ولا جهاز الملعق نقله؟ أه
+
+360
+00:27:20,140 --> 00:27:25,820
+بس ليش .. ليش عملنا اتنين مش واحد؟ لكن هو بيعمل
+
+361
+00:27:25,820 --> 00:27:29,200
+response، هو .. وعشانك .. عشانك ابناش famine اللي
+
+362
+00:27:29,200 --> 00:27:31,680
+هو ال disease، وبالتالي المفروض انه عمل response
+
+363
+00:27:37,090 --> 00:27:40,750
+يعني ال antibodies بتبدأ تنخفض فبالتالي مضطرين
+
+364
+00:27:40,750 --> 00:27:44,310
+نعطي .. نعطي زي نوع من ال booster dose جرعة
+
+365
+00:27:44,310 --> 00:27:47,850
+نشطة هذا امكن الكلام الأقرب و الدليل على ذلك على
+
+366
+00:27:47,850 --> 00:27:51,770
+كلامك انه كلامك دقيق هو انه نسبة الفيروس في ال
+
+367
+00:27:51,770 --> 00:27:56,910
+vaccine تبع ال zoster أعلى ب 14 مرة من نسبته في ال
+
+368
+00:27:56,910 --> 00:28:00,280
+chicken box عشان نعطيمناعة قوية أو ندعم لهذه
+
+369
+00:28:00,280 --> 00:28:04,200
+المناعة بشكل قوي لأنه على سن ستين بيكون ال
+
+370
+00:28:04,200 --> 00:28:09,980
+response بالفعل أضعف من على سن اللي هو صغير اذا
+
+371
+00:28:09,980 --> 00:28:15,960
+كمان مرة اتفقنا ان ال frequency of zoster increase
+
+372
+00:28:15,960 --> 00:28:20,560
+with age نبدأ نتكلم عن الـ Varicella، و الـ
+
+373
+00:28:20,560 --> 00:28:22,960
+Varicella بيقولنا إنه incubation period تبعها من
+
+374
+00:28:22,960 --> 00:28:28,160
+14 إلى 21 يوم، و بيبدأ عندنا Prodromal Symptoms،
+
+375
+00:28:28,160 --> 00:28:30,320
+عارفين الـ Prodromal Symptoms اللي قلنا عنها؟ اللي 
+
+376
+00:28:30,320 --> 00:28:35,960
+شعر أنه بدي يمرض، ممكن يكون Non-specific Symptoms
+
+377
+00:28:36,760 --> 00:28:41,420
+بعدين بيبدأ يظهر اللي هو الـ papulovascular rash و
+
+378
+00:28:41,420 --> 00:28:45,500
+الـ vesicular rash عفواً، و هذا الـ vesicular rash
+
+379
+00:28:45,500 --> 00:28:48,440
+بيبدأ على الجذع تبع الإنسان، جذع الإنسان يعني الصدر
+
+380
+00:28:48,440 --> 00:28:52,400
+و الظهر، و بعدين بينتشر إلى الأطراف و إلى الوجه
+
+381
+00:28:52,400 --> 00:28:58,300
+بيكون بشكل crops يعني بشكل خلينا نقول حبيبات
+
+382
+00:28:58,300 --> 00:29:02,080
+متلاسقة مع بعضهم البعض، قريبة من بعض، مش متباعدة
+
+383
+00:29:02,080 --> 00:29:04,580
+بتكون بشكل قريب من بعض
+
+384
+00:29:07,940 --> 00:29:11,020
+من أشهر الـ .. الـ .. الـ symptoms اللي هي الـ itching
+
+385
+00:29:11,020 --> 00:29:15,120
+أو بيسموها pruritus، الـ itching يعني هو الممكن هو
+
+386
+00:29:15,120 --> 00:29:19,820
+الخطر الأساسي اللي .. اللي ممكن يعني يصاحب معظم
+
+387
+00:29:19,820 --> 00:29:23,240
+الأطفال، لإن الأطفال ده المناعة الجيدة غالباً
+
+388
+00:29:23,240 --> 00:29:28,160
+بياشفوا تلقائياً، لكن الـ itching أو الحكا بتسبب أن
+
+389
+00:29:28,160 --> 00:29:33,440
+الطفل ممكن يجرح مكان الـ physical، إذا جرح الـ
+
+390
+00:29:33,440 --> 00:29:37,480
+physical غالباً بتكون إمكانية إصابتها بـ secondary
+
+391
+00:29:37,480 --> 00:29:41,420
+infection من بكتيريا عالية جداً، و بتترك scar ..
+
+392
+00:29:41,420 --> 00:29:46,560
+scar يعني اللي هي نضبة، والحقيقة أنه لا أحد يرغب
+
+393
+00:29:46,560 --> 00:29:49,940
+بوجود نضوب، لأنه الأن تتطلع على الوجه .. الوجه كله
+
+394
+00:29:49,940 --> 00:29:54,020
+مليء بالـ physical تمام؟ وبتالي إذا صار في حكة، لذلك
+
+395
+00:29:54,020 --> 00:30:00,690
+أحد أهمّ يعني العلاجات أنه نعطي ملطفات تمام للأطفال
+
+396
+00:30:00,690 --> 00:30:04,490
+حتى يخفف من اللي هو التهيج و الحكا عند هؤلاء
+
+397
+00:30:04,490 --> 00:30:10,790
+الأطفال، الجملة
+
+398
+00:30:10,790 --> 00:30:13,850
+اللي احنا قولنا لكم فسروها، و طلعنا احنا بنخشّينها
+
+399
+00:30:13,850 --> 00:30:17,830
+اللي هي لماذا الـ varicella في الـ childhood بتكون mild
+
+400
+00:30:17,830 --> 00:30:23,310
+لكن في الـ adult بتكون severe، الـVaricella pneumonia
+
+401
+00:30:23,310 --> 00:30:28,530
+and encephalitis are the major rare complications،
+
+402
+00:30:28,530 --> 00:30:33,710
+كلمة rare يعني one in thousands، one in thousands،
+
+403
+00:30:33,710 --> 00:30:37,950
+rare complications occurring more often in adults،
+
+404
+00:30:37,950 --> 00:30:42,650
+طبعاً فرصة ظهورها في الكبار بتكون أعلى من اللي
+
+405
+00:30:42,650 --> 00:30:47,110
+هم الصغار، في نقطة مهمة جداً، غير مقتصرة على
+
+406
+00:30:47,110 --> 00:30:50,610
+الـVaricella zoster، اسمها Ray's syndrome، Ray's
+
+407
+00:30:50,610 --> 00:30:55,240
+syndrome، سمعتوا أن الاسبيرين في بعض الحالات مش
+
+408
+00:30:55,240 --> 00:31:00,540
+كويس؟ الاسبيرين في بعض الحالات مش كويس، في حالتين،
+
+409
+00:31:00,540 --> 00:31:04,280
+لما يكون الطفل عنده influenza caused by influenza
+
+410
+00:31:04,280 --> 00:31:09,620
+type B، و لما يكون عنده varicella، إذا أعطينا الطفل
+
+411
+00:31:09,620 --> 00:31:15,600
+اسبيرين كخافض للحرارة، تمام؟ ممكن ينتج عنده
+
+412
+00:31:16,550 --> 00:31:19,290
+condition بنسميه هنا ليه الـ syndrome، كيف بينتج الـ
+
+413
+00:31:19,290 --> 00:31:23,970
+condition، و كيف بشتغل الـ aspirin ماحدش عارف، لكن
+
+414
+00:31:23,970 --> 00:31:27,910
+كنا عارفين أنه بينتج عنه encephalopathy و liver
+
+415
+00:31:27,910 --> 00:31:31,490
+degeneration يعني خلل في الدماغ و خلل في وين؟ في
+
+416
+00:31:31,490 --> 00:31:34,710
+الـ liver، في الحالتين يعني عشانك بنقول أن الـ
+
+417
+00:31:34,710 --> 00:31:39,150
+aspirin is contraindicated لا يعطى لا في حالة الـ
+
+418
+00:31:39,150 --> 00:31:42,250
+varicella zoster، ولا في حالة اللي هو الـ influenza
+
+419
+00:31:42,250 --> 00:31:43,270
+virus
+
+420
+00:31:46,350 --> 00:31:51,390
+Exhauster كما ذكرنا هو عبارة عن وجود painful
+
+421
+00:31:51,390 --> 00:31:56,950
+vesicles يعني مؤلمة، الحوائز صارت مؤلمة along the
+
+422
+00:31:56,950 --> 00:32:00,770
+course of a sensory nerve، along the course يعني
+
+423
+00:32:00,770 --> 00:32:05,390
+على طول امتداد هذا الـ nerve، وقلنا لكم السبب أنه مش
+
+424
+00:32:05,390 --> 00:32:11,400
+لاجي مكان يهرب إليه إلا المقابل تبع هذا الـ nerve في
+
+425
+00:32:11,400 --> 00:32:16,780
+condition بيسموه post-zoster neuralgia أو اعتلال
+
+426
+00:32:16,780 --> 00:32:23,420
+عصبي ما بعد الـ zoster، واسم ثاني له post-herpetic
+
+427
+00:32:23,420 --> 00:32:29,190
+neuralgia، ليش post-herpetic؟ لأنه أصلاً الـ Zoster
+
+428
+00:32:29,190 --> 00:32:32,570
+Virus أو الـ Varicella Zoster Virus هو أحد أعضاء
+
+429
+00:32:32,570 --> 00:32:36,790
+من الـ Herpes Virus family، تنسوا الكلام هذا، احنا
+
+430
+00:32:36,790 --> 00:32:39,730
+صحيح بنناقش في Herpes Simplex Type I و Type II و
+
+431
+00:32:39,730 --> 00:32:43,870
+Varicella لكن كلهم تحت عيلة اسمها Herpes Virus
+
+432
+00:32:43,870 --> 00:32:48,510
+Family، برضه هذا الـ condition can be debilitating
+
+433
+00:32:48,510 --> 00:32:53,910
+و قلنا ممكن يكون مؤثر لأداء وظيفة الإنسان، من أشهر
+
+434
+00:32:53,910 --> 00:32:57,510
+ومن أخطر الـ complications اللي ممكن تحدث جراءها
+
+435
+00:32:57,510 --> 00:33:00,630
+ويسموها life threatening infection في
+
+436
+00:33:00,630 --> 00:33:05,130
+الـ varicella zoster اللي هي pneumonia، وهذه سيئة للغاية
+
+437
+00:33:05,130 --> 00:33:12,910
+الـ lab diagnosis في الـ varicella zoster غالباً يعني زمان
+
+438
+00:33:12,910 --> 00:33:16,950
+ماكانوش ينتبهوا للـ laboratory diagnosis، ليش؟ لأن الـ
+
+439
+00:33:16,950 --> 00:33:21,630
+clinical picture الصورة السريرية للمرض سواء كان في
+
+440
+00:33:21,630 --> 00:33:25,450
+الـ primary infection اللي هي الـ Varicella أو في الـ
+
+441
+00:33:25,450 --> 00:33:29,790
+.. الـ .. الـ reactivation اللي هو الـ Zoster الـ
+
+442
+00:33:29,790 --> 00:33:32,770
+clinical picture كانت واضحة جداً ولا زالت واضحة جداً
+
+443
+00:33:32,770 --> 00:33:38,050
+لكن بيكونوا تعرفوا أنه من بعد 2001 نسبة الإصابة
+
+444
+00:33:38,050 --> 00:33:42,900
+بالمرض انخفضت، انخفاض نسبة الإصابة بالمرض
+
+445
+00:33:42,900 --> 00:33:47,380
+يجعل من الأطباء أقل خبرة في تشخيص المرض، عندما يرى
+
+446
+00:33:47,380 --> 00:33:50,680
+الطبيب مراراً أو تكراراً نفس الصورة بيصير الأمر
+
+447
+00:33:50,680 --> 00:33:56,440
+بالنسبة له سهل، فالـ diagnosis هو ضرورة من الضروريات
+
+448
+00:33:56,440 --> 00:34:01,640
+واحدة منهم، نرجع لمين؟ للـ Tzank smear، Tzank smear
+
+449
+00:34:01,640 --> 00:34:04,240
+شفناها في herpes simplex type 1 و type 2
+
+450
+00:34:04,240 --> 00:34:08,910
+وhyperbarisella zoster، وجود الـ Multinucleated
+
+451
+00:34:08,910 --> 00:34:15,050
+Giant Cell برضه يعني عامل مساعد، وأيضاً يمكن زراعة
+
+452
+00:34:15,050 --> 00:34:19,610
+أو استزراع الفيروس على Cell Culture، وممكن نتعرف
+
+453
+00:34:19,610 --> 00:34:23,430
+على الفيروس من خلال اللي هو Specific Anti Serum، طب
+
+454
+00:34:23,430 --> 00:34:27,570
+احنا قلنا قبل قليل بنزرع عشان الفيروس يكون كميته
+
+455
+00:34:27,570 --> 00:34:31,410
+كبيرة كافية لإجراء فحوصات، من ضمن هذه الفحوصات أن
+
+456
+00:34:31,410 --> 00:34:35,590
+نشوف اللي هو Specific Anti Body Agglutination Test
+
+457
+00:34:36,500 --> 00:34:42,180
+أيضاً الارتفاع في تركيز الـ antibody في جسم الإنسان
+
+458
+00:34:42,180 --> 00:34:48,400
+هو كويس لتشخيص الـ varicella لكن ليس له قيمة في
+
+459
+00:34:48,400 --> 00:34:52,900
+تشخيص مين؟ الـ zoster، أعتقد أنه السبب واضح، أنه أصلاً
+
+460
+00:34:52,900 --> 00:34:57,680
+بيصير فينا ارتفاع في الـ antibody بعد درجة من
+
+461
+00:34:57,680 --> 00:35:00,020
+العلاجات، زي ما احنا قلنا بالأول، تشخيص كان بدون
+
+462
+00:35:00,020 --> 00:35:05,450
+تشخيص مضبوط، وكان كلينيكلي، التشخيص أيضاً بالنسبة لي
+
+463
+00:35:05,450 --> 00:35:11,910
+العلاجات، غالباً العلاج تبع الـ Varicella Zoster كان
+
+464
+00:35:11,910 --> 00:35:15,970
+مش ضروري خاصة في الـ immunocompetent individuals
+
+465
+00:35:15,970 --> 00:35:18,950
+يعني الناس اللي هم معروف أنه مناعتهم جيدة
+
+466
+00:35:18,950 --> 00:35:24,650
+ما بنعطيهم كان علاج، لكن الـ immunocompetent
+
+467
+00:35:24,650 --> 00:35:30,140
+adults بناكلها مامي على أطفالها، الـ Immunocompetent
+
+468
+00:35:30,140 --> 00:35:32,720
+adult ما احنا قلنا لكم قبل شوية أنه الـ severity
+
+469
+00:35:32,720 --> 00:35:35,340
+بتكون فيه عندهم ايه؟ عالية، وبالتالي هدول الناس
+
+470
+00:35:35,340 --> 00:35:39,660
+محتاجين أنه هنا نخفف عنهم، ممكن نستخدم اللي هو
+
+471
+00:35:39,660 --> 00:35:44,080
+الـ acyclovir مرة أخرى، to reduce the duration and
+
+472
+00:35:44,080 --> 00:35:49,100
+severity of symptoms، إذا الـ acyclovir علاج ليه؟ ليس
+
+473
+00:35:49,100 --> 00:35:54,460
+للقضاء على الفيروس، وإنما لتقليل الحدة وتخفيف المدة
+
+474
+00:35:54,460 --> 00:35:59,440
+الزمنية، يبقى الأطفال مش محتاجين علاج، الـ adults اللي
+
+475
+00:35:59,440 --> 00:36:02,320
+عندهم moderate أو severe infection محتاجين أن احنا
+
+476
+00:36:02,320 --> 00:36:05,380
+نعطيهم acyclovir، و عرفنا ليش، عشان نقصر الفترة و
+
+477
+00:36:05,380 --> 00:36:07,860
+نقلل الـ severity اللي عندي لمين؟ للـ
+
+478
+00:36:07,860 --> 00:36:11,660
+immunocompromised children and adults with
+
+479
+00:36:11,660 --> 00:36:15,460
+chickenpox أو زوستر أو disseminated disease should
+
+480
+00:36:15,460 --> 00:36:18,180
+be treated .. الآن ما فيش خيار انها should be
+
+481
+00:36:18,180 --> 00:36:22,880
+treated with acyclovir، طبعاً فوسكرنت كمان مرة
+
+482
+00:36:22,880 --> 00:36:27,810
+يستخدم لحالات مين؟ اللي هم Acyclovir-resistant
+
+483
+00:36:27,810 --> 00:36:34,050
+strains. Two drugs similar to acyclovir اللي هم
+
+484
+00:36:34,050 --> 00:36:37,610
+الـ famciclovir و الـ valacyclovir، وده مرّ معنا قبل
+
+485
+00:36:37,610 --> 00:36:42,790
+دقائق، can be used in patients with zoster to
+
+486
+00:36:42,790 --> 00:36:47,190
+accelerate healing of the lesions، فاكرين قبل برضه
+
+487
+00:36:47,190 --> 00:36:52,830
+قليل قلنا أنّه الزوستر قد يعني يبقى لعدة أسابيع
+
+488
+00:36:52,830 --> 00:36:57,370
+والألم المصاحب له ألم فظيع، وبالتالي إذا بدنا نخفف
+
+489
+00:36:57,370 --> 00:37:00,170
+عن هدول المرضى وخاصة في ذوي المناعة المنخفضة
+
+490
+00:37:00,170 --> 00:37:03,950
+ممكن نعطيهم برضه العقاقير اللي قلنا عنها، الـ valcyclovir
+
+491
+00:37:03,950 --> 00:37:05,650
+و الـ valacyclovir
+
+492
+00:37:11,730 --> 00:37:16,070
+احنا ذكرنا أن الـ valacyclovir و الـ famciclovir
+
+493
+00:37:16,070 --> 00:37:17,970
+بيخففوا من الأعراض
+
+494
+00:37:20,730 --> 00:37:25,990
+ثبت أنه ما لهمش أي تأثير على ما يسمى بالـ post
+
+495
+00:37:25,990 --> 00:37:30,890
+-herpetic أو post-zoster neuralgia، أعطيت أو ما
+
+496
+00:37:30,890 --> 00:37:34,990
+أعطيت إمكانية حدوث الـ post-herpetic neuralgia
+
+497
+00:37:34,990 --> 00:37:40,230
+موجودة و مرتفعة تمام؟ يعني العلاج ما أثرش على الـ
+
+498
+00:37:40,230 --> 00:37:46,930
+outcome على هذا الـ condition، الـ prevention كيف
+
+499
+00:37:46,930 --> 00:37:52,400
+بنتقل هو؟ كيف بنتقل؟ مش بيقول إنها Respiratory،
+
+500
+00:37:52,400 --> 00:37:55,360
+يعني بيقول إنها Respiratory وممكن نكون عبر مين؟ الـ 
+
+501
+00:37:55,360 --> 00:37:59,640
+direct contact عبر اللي هو الـ vesicles. الآن لما
+
+502
+00:37:59,640 --> 00:38:03,540
+بيكون عندي vaccine، بكل فخر واعتزاز بنقول لدينا 
+
+503
+00:38:03,540 --> 00:38:08,620
+vaccines، وهي هذه يعني بنحطها في مقدمات الـ .. الـ
+
+504
+00:38:08,620 --> 00:38:12,030
+.. الـ prevention، تمام؟ فالآن أنا فيه اندي two
+
+505
+00:38:12,030 --> 00:38:15,510
+vaccines واحد اسمه vary-vax و vary من varicella
+
+506
+00:38:15,510 --> 00:38:20,390
+والثاني zoster-vax وهذا من ايه؟ من zoster وأنا
+
+507
+00:38:20,390 --> 00:38:23,670
+أعتقد أنه نقشنا هذا الموضوع لماذا هناك two
+
+508
+00:38:23,670 --> 00:38:28,670
+vaccines واحد لفاريسيلا واحد لزوستر وذكرنا لكم أن
+
+509
+00:38:28,670 --> 00:38:33,550
+الفرق الأساسي بينهم هو أن الـ zoster-vax بيحتوي على
+
+510
+00:38:33,550 --> 00:38:38,990
+أربعة عشر ضعف تركيز الفيروس من اللي هو الـ vary-vax
+
+511
+00:38:41,050 --> 00:38:43,050
+يُعطى الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+512
+00:38:43,050 --> 00:38:43,810
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ 
+
+513
+00:38:43,810 --> 00:38:45,650
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+514
+00:38:45,650 --> 00:38:45,870
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+515
+00:38:45,870 --> 00:38:52,830
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+516
+00:38:52,830 --> 00:38:56,590
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+517
+00:38:56,590 --> 00:38:56,610
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+518
+00:38:56,610 --> 00:38:57,710
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+519
+00:38:57,710 --> 00:38:58,070
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+520
+00:38:58,070 --> 00:38:58,670
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+521
+00:39:05,980 --> 00:39:10,500
+ليش بنختار الفئة العمرية؟ هل هو يعني نوع من التنظيم 
+
+522
+00:39:10,500 --> 00:39:17,200
+عشان نخلي نعمل جدول؟ ولا فيه الـ scientific basis؟
+
+523
+00:39:17,200 --> 00:39:20,500
+الـ scientific basis والحقيقة أنه لو دينا دورنا
+
+524
+00:39:20,500 --> 00:39:25,600
+على بتاقات التطعيم أو على أنظمة التطعيم اللي كانت
+
+525
+00:39:25,600 --> 00:39:28,660
+موجودة في فلسطين هلاجي أنها مرت بتغيرات والتغيرات
+
+526
+00:39:28,660 --> 00:39:31,280
+هذه مرت بناء على دراسات مش دراسات محلية غالبا
+
+527
+00:39:31,280 --> 00:39:39,180
+دراسات دولية مثلا الأم اللي عندها antibody لـ
+
+528
+00:39:39,180 --> 00:39:44,860
+الفاريسيلا بتعطي ابنها أو بنتها هذا الـ antibody لو
+
+529
+00:39:44,860 --> 00:39:49,160
+جينا نحكي عن الطفل وهو عمره أسبوع أو شهر أو شهرين بالـ
+
+530
+00:39:49,160 --> 00:39:53,710
+vaccine اللي هو Serotype 1، الـ vaccine هيبقى عن
+
+531
+00:39:53,710 --> 00:39:57,030
+فيروس، وأنا عندي Antibody، فالـ Antibody على طول
+
+532
+00:39:57,030 --> 00:40:01,090
+بيهاجم من الفيروس، فبيقلل من كفاءة الـ vaccine،
+
+533
+00:40:01,090 --> 00:40:04,450
+فبتالي لما بنختار احنا الفترات، بنعرف ايش اللي
+
+534
+00:40:04,450 --> 00:40:08,890
+ممكن يكون موجود من Antibody عند الطفل أو ما كانش
+
+535
+00:40:08,890 --> 00:40:12,710
+موجود، إذا إن هو مرة أخرى مش Hub hazard وإنما يعني
+
+536
+00:40:12,710 --> 00:40:19,010
+planned أو مخطط، لأواخد 13 سنة والزوزة الـ vaccine
+
+537
+00:40:19,010 --> 00:40:24,210
+بيعطي للي فوق الـ 60 سنة طبعا الجملة اللي قلناها أن
+
+538
+00:40:24,210 --> 00:40:29,350
+الفرصة بتزداد بالإصابة كلما تقدم بنا العمر هذا هو
+
+539
+00:40:29,350 --> 00:40:34,490
+السبب اللي خلى عنا نتكلم عنه عمر الـ 60 طيب الـ vaccine
+
+540
+00:40:34,490 --> 00:40:38,830
+بيحتوي على live virus وبالتالي يجب أن يعطي للناس
+
+541
+00:40:38,830 --> 00:40:43,570
+اللي عندهم مناعة منخفضة واحنا ممكن ذكرنا هذا الكلام
+
+542
+00:40:43,570 --> 00:40:48,630
+التطعيم يا جماعة يجب اللي يحدث للأطفال الذين يعانون
+
+543
+00:40:48,630 --> 00:40:53,090
+من أي إصابة أو عدوى ولو كان مناعته منخفضة بدنا
+
+544
+00:40:53,090 --> 00:40:58,130
+نستنى فترة وجيزة حتى تتحسن صحة الطفل حتى نعطيه الـ
+
+545
+00:40:58,130 --> 00:41:02,510
+vaccine لأنه بنخاف خاصة لما اتكلمنا عن الـ live
+
+546
+00:41:02,510 --> 00:41:06,590
+attenuated vaccines في الـ immun compromise هذه
+
+547
+00:41:06,590 --> 00:41:11,350
+live فممكن تعمل disease عند هدول الناس وبالتالي
+
+548
+00:41:11,350 --> 00:41:17,510
+بالفعل لازم ننتبه لهذا الموضوع لو حصل وأعطينا
+
+549
+00:41:17,510 --> 00:41:22,570
+vaccine وصار disease، هل هناك حلول؟ نعم في حلول،
+
+550
+00:41:22,570 --> 00:41:26,050
+في عندنا الـ acyclovir وفي عندنا الـ varicella
+
+551
+00:41:26,050 --> 00:41:31,040
+zoster immunoglobulins هذا immunoglobulin هذا جاهزة
+
+552
+00:41:31,040 --> 00:41:36,740
+من برا تمام عشان نكافح فيها المضاعفات اللي ممكن
+
+553
+00:41:36,740 --> 00:41:41,000
+تنشأ من الـ vaccination أو عند أي شخص أصلا عنده
+
+554
+00:41:41,000 --> 00:41:44,500
+مضاعفات ممكن يُعطى هذا الـ immunoglobulin هذا
+
+555
+00:41:44,500 --> 00:41:47,740
+passive ولا active passive passive passive passive
+
+556
+00:41:47,740 --> 00:41:47,820
+passive passive passive passive passive passive
+
+557
+00:41:47,820 --> 00:41:50,740
+passive passive passive passive passive passive
+
+558
+00:41:50,740 --> 00:41:51,560
+passive passive passive passive passive passive
+
+559
+00:41:51,560 --> 00:41:51,600
+passive passive passive passive passive passive
+
+560
+00:41:51,600 --> 00:41:52,160
+passive passive passive passive passive passive
+
+561
+00:41:52,160 --> 00:41:52,200
+passive passive passive passive passive passive
+
+562
+00:41:52,200 --> 00:41:52,220
+passive passive passive passive passive passive
+
+563
+00:41:52,220 --> 00:41:52,240
+passive passive passive passive passive passive
+
+564
+00:41:52,240 --> 00:41:52,300
+passive passive passive passive passive passive
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU_postprocess.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a55eca9a74f02d53b5b73f4205edd2b4fac66f78
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU_postprocess.srt
@@ -0,0 +1,2256 @@
+1
+00:00:20,810 --> 00:00:23,430
+بسم الله الرحمن الرحيم نكمل ان شاء الله ما بدأنا
+
+2
+00:00:23,430 --> 00:00:27,850
+المحاضرة السابقة في ال DNA viruses ومازلنا و سنبقى
+
+3
+00:00:27,850 --> 00:00:31,990
+ان شاء الله لمحاضرتين قادمتين في ال herpes viruses
+
+4
+00:00:31,990 --> 00:00:35,810
+و ال herpes viruses جونا مجموعة مكونة من ستة أفراد
+
+5
+00:00:35,810 --> 00:00:38,850
+على الأقل herpes simplex type 1, herpes simplex
+
+6
+00:00:38,850 --> 00:00:42,670
+type 2, baricella zoster, cytomegalovirus,
+
+7
+00:00:43,010 --> 00:00:46,730
+iberstein bar virus و اتحدثنا في الأخير على اللي
+
+8
+00:00:46,730 --> 00:00:52,090
+هو ال human herpes virus type 8نقشنا بعض ال .. ال
+
+9
+00:00:52,090 --> 00:00:54,810
+.. ال general characteristics لهذه المجموعة وشوفنا
+
+10
+00:00:54,810 --> 00:00:59,090
+انه هي unique in many ways مثلا بأن هي الوحيدة
+
+11
+00:00:59,090 --> 00:01:00,890
+اللي بتاخد ال envelope تبعها من ال nuclear
+
+12
+00:01:00,890 --> 00:01:04,470
+membrane هي من الميكروبات اللي .. اللي لها القدرة
+
+13
+00:01:04,470 --> 00:01:08,690
+على ال latency وهذه القدرة أكسبتها يعني مهارات
+
+14
+00:01:08,690 --> 00:01:14,360
+عديدة وانت تخيلوا انهأكتر من تسعين بالمائة، يمكن
+
+15
+00:01:14,360 --> 00:01:16,860
+مائة بالمائة من كوكب الأرض مصاب بأحد هذه
+
+16
+00:01:16,860 --> 00:01:19,440
+الفيروسات، يا إما بـ Herpes Simplex Type 1، يا إما
+
+17
+00:01:19,440 --> 00:01:22,720
+بـ Epstein-Barr Virus، يا إما بـCytomegalovirus،
+
+18
+00:01:22,720 --> 00:01:26,060
+لأنه .. هنشوف كمان شوية، لو تسعين بالمائة مثلا من
+
+19
+00:01:26,060 --> 00:01:28,740
+السكان في الولايات المتحدة عندهم Epstein-Barr
+
+20
+00:01:28,740 --> 00:01:33,170
+Virus، تمانين بالمية عندهم Cytomegalovirusبشكل عام
+
+21
+00:01:33,170 --> 00:01:37,590
+عندهم أيضا حوالي 80% من herpes simplex type 1 وفيه
+
+22
+00:01:37,590 --> 00:01:40,410
+زيادة في herpes simplex type 2 إذا من الفيروسات
+
+23
+00:01:40,410 --> 00:01:45,230
+الشائعة و الشهيرة و المنتشرة وصلنا على ال clinical
+
+24
+00:01:45,230 --> 00:01:51,300
+findings وهي لوحة مكررةلكن ملخصة نوعا ما إلى ما
+
+25
+00:01:51,300 --> 00:01:56,300
+ذكرناه في السابق أن جنجفوستيميتيتس، Herpes
+
+26
+00:01:56,300 --> 00:02:00,320
+Labialis، Keratoconjectivitis، Encephalitis،
+
+27
+00:02:00,320 --> 00:02:03,480
+Herpetic Whitlow و Herpes Gladiatorum والتنتين
+
+28
+00:02:03,480 --> 00:02:07,620
+الأخرانيات هدولة هم إصابات للـ Herpes في أصابع أو
+
+29
+00:02:07,620 --> 00:02:11,720
+في أطراف الأيدانطبعا هنتكلم يا عمينا عن Herpes
+
+30
+00:02:11,720 --> 00:02:17,000
+Simplex Type 1 هذه الأمراض بتصيبه ممكن عند ال very
+
+31
+00:02:17,000 --> 00:02:20,340
+very immunocompromised patients يصير فيه حادث
+
+32
+00:02:20,340 --> 00:02:26,000
+اسفاجيتس وممكن كمان نيومونيا وفي الحالتين it is a
+
+33
+00:02:26,000 --> 00:02:28,660
+devastating disease نيومونيتس due to Herpes
+
+34
+00:02:28,660 --> 00:02:33,840
+Simplex Type 1 بتكون مدمرة للغايةالـ Clinical
+
+35
+00:02:33,840 --> 00:02:37,560
+findings لـ Herpes Simplex Type 2 أن جينة الهيربز،
+
+36
+00:02:37,560 --> 00:02:39,840
+نيوناتا الهيربز بالإضافة إلى الـ Aseptic
+
+37
+00:02:39,840 --> 00:02:43,060
+Meningitis و أعتقد أنه تطرحنا لمصطلح Aseptic
+
+38
+00:02:43,060 --> 00:02:48,580
+Meningitis أنه يعني الكائن المسبب غير موجود أو لا
+
+39
+00:02:48,580 --> 00:02:52,460
+يمكن عزله بالـ Regular Techniquesفي ال lab
+
+40
+00:02:52,460 --> 00:02:56,400
+diagnosis عزل الفيروس في ال cell culture يعتبر
+
+41
+00:02:56,400 --> 00:03:00,920
+واحدة من أهم الطرق المستخدمة في تشخيص هذا الفيروس
+
+42
+00:03:00,920 --> 00:03:06,400
+بالاضافة إلى طبعا تعرفينلما كنا نعزل البكتيريا على
+
+43
+00:03:06,400 --> 00:03:10,300
+الأطباق المكونكي و ال blood agar كنا نكاثرها و
+
+44
+00:03:10,300 --> 00:03:14,160
+نشوف مستعمرات مظبوط لكن هذه المستعمرات ولا بأي حال
+
+45
+00:03:14,160 --> 00:03:19,960
+من الأحوال كانت هي المشخصة لنوع البكتيريا فكذلك
+
+46
+00:03:19,960 --> 00:03:23,300
+الأمر بالنسبة لمزرعة الفيروسات نحن نزرع الفيروسات
+
+47
+00:03:23,300 --> 00:03:27,920
+على ال cell culture ثم نقوم بإجراء فحوصات على ال
+
+48
+00:03:27,920 --> 00:03:30,140
+large number اللي صار عندنا من الفيروسات في ال
+
+49
+00:03:30,140 --> 00:03:35,200
+cell culture قد يساعدنابعض الأحيان انه ال virus
+
+50
+00:03:35,200 --> 00:03:38,460
+بيعمل cytopathic effect و اظن ال herpes virus
+
+51
+00:03:38,460 --> 00:03:40,640
+بتعمل cytopathic effect ايش هو cytopathic effect
+
+52
+00:03:40,640 --> 00:03:46,140
+اللي هو ال cytomegalo او ال giant cell formation
+
+53
+00:03:46,140 --> 00:03:50,280
+هذا كان احد ال ال ال خدنا نقول ال hallmarks لل
+
+54
+00:03:50,280 --> 00:03:54,660
+herpes viruses و كلمة cytomegalovirus اصلا cmv
+
+55
+00:03:54,660 --> 00:04:01,630
+معناها الفيروس المضخم للخلاياالـ cytopathic effect
+
+56
+00:04:01,630 --> 00:04:05,690
+بحث بيكون كتير مميز على اللي هو cell culture
+
+57
+00:04:05,690 --> 00:04:09,970
+والجميل في هذا الموضوع أنه قد يظهر الـ cytopathic
+
+58
+00:04:09,970 --> 00:04:13,730
+effect في يوم إلى ثلاث أيام من الزراعة، يعني وقت
+
+59
+00:04:13,730 --> 00:04:19,830
+قصير بالنسبة لزراعة الفيروسة، لكن قد نحتاج إلى
+
+60
+00:04:19,830 --> 00:04:25,430
+تقنيات منعية زي الـ ELISA للكشف عن الـantigenفي
+
+61
+00:04:25,430 --> 00:04:27,930
+حاجة ما اتزنق سمير حكينا عنها المرة الماضية كنا
+
+62
+00:04:27,930 --> 00:04:32,190
+انه بناخد سواب من قاع اللي هو ال Legion سواء كان
+
+63
+00:04:32,190 --> 00:04:36,830
+Herpes Simplex Type I أو Herpes Simplex Type II و
+
+64
+00:04:36,830 --> 00:04:39,590
+بنعمله Gem Staining و بنشوف ال Multinucleated
+
+65
+00:04:39,590 --> 00:04:41,790
+Giant Cell أيضا في هذا السمير
+
+66
+00:04:45,640 --> 00:04:49,000
+ممكن أيضا كمان نكشف عن ال .. ال .. ال herpes
+
+67
+00:04:49,000 --> 00:04:52,200
+viruses سواء type 1 و type 2 من خلال اللي هو ال
+
+68
+00:04:52,200 --> 00:04:55,980
+PCR يعني نكشف عن ال DNA من خلال اللي هو ال PCR
+
+69
+00:04:55,980 --> 00:04:59,660
+culture
+
+70
+00:04:59,660 --> 00:05:05,480
+زاد PCR بمشي بمشي الحال كمانومن ال culture نعمل
+
+71
+00:05:05,480 --> 00:05:11,580
+PCR يعني بمعنى اخر انا اخد عينة و اعملها culture و
+
+72
+00:05:11,580 --> 00:05:15,260
+من ال culture اعمل ال PCR هذا طبعا بزيد ال
+
+73
+00:05:15,260 --> 00:05:19,910
+sensitivity تبعات ال PCRفي كمان حاجة اسمها ال
+
+74
+00:05:19,910 --> 00:05:23,810
+neutralization test وكلمة ال neutralization test
+
+75
+00:05:23,810 --> 00:05:28,930
+معناها ان ال antibody اللي عند المريض يستخدم
+
+76
+00:05:28,930 --> 00:05:33,990
+لإيقاف تأثير الفيروس انا عندي فيروس مشهور اسمه
+
+77
+00:05:33,990 --> 00:05:38,070
+herpes simplex type 1 وانا شاكر ان المريض عنده
+
+78
+00:05:38,070 --> 00:05:42,350
+antibodies لل herpes simplex type 1 تمام؟ ناخد ال
+
+79
+00:05:42,350 --> 00:05:47,560
+serum تبعه و بنخلط ال serumمع الفيروس وبنحطهم
+
+80
+00:05:47,560 --> 00:05:52,680
+اتنين على سلك culture إذا توقف عن صناعة
+
+81
+00:05:52,680 --> 00:05:56,420
+الـcytopathic effect باه مين اللي وجفه؟ ال
+
+82
+00:05:56,420 --> 00:05:59,880
+antibody لوموردومين في السيرة بيبقى بقدر أكشف عن
+
+83
+00:05:59,880 --> 00:06:03,620
+موجود antibody من خلال neutralization test مرة
+
+84
+00:06:03,620 --> 00:06:09,180
+أخرى بيقول إنه الآن الفيروس أنا عندي ك agent في
+
+85
+00:06:09,180 --> 00:06:12,940
+المختبر لو زرعته أنا من عندي في المختبر لو زرعته
+
+86
+00:06:12,940 --> 00:06:16,080
+على سلك culture هيعطيني cytopathic effectلو أخدت
+
+87
+00:06:16,080 --> 00:06:20,500
+من ال patient سيرام و حطيته على ال cell culture و
+
+88
+00:06:20,500 --> 00:06:24,840
+توقف الفيروس عن صناع ال cytopathic effect، ما الذي
+
+89
+00:06:24,840 --> 00:06:29,000
+أوقفه هو ال antibodies اللي موجودة في السيرام، و
+
+90
+00:06:29,000 --> 00:06:32,320
+بما أنه أوقف الفيروس و هي specific له، فنقدر نقول
+
+91
+00:06:32,320 --> 00:06:35,800
+إن الإنسان عنده antibodies لهذا الفيروس
+
+92
+00:06:39,060 --> 00:06:42,640
+طبعا ان احنا معرفة ال antibody وزيادتها في الدسم
+
+93
+00:06:42,640 --> 00:06:45,980
+بتساعدنا في تشخيص ل primary infection لكن ما
+
+94
+00:06:45,980 --> 00:06:48,900
+بتساعدنا في تشخيص من ال reactivation لان already
+
+95
+00:06:48,900 --> 00:06:54,000
+ال antibodies موجودة و بشكل مستمر بالنسبة للعلاج
+
+96
+00:06:54,000 --> 00:06:58,440
+اشهر علاج مار علينا في الفيروسات احنا لحد الان
+
+97
+00:06:58,440 --> 00:07:04,280
+اللي هو الacyclovirوهو عبارة عن نوكليوتايد analog
+
+98
+00:07:04,280 --> 00:07:08,480
+وإيش يعني نوكليوتايد analog؟ يعني شبيه بالقواعد
+
+99
+00:07:08,480 --> 00:07:12,600
+النيتروجينية تبع ال DNA إيش القواعد النيتروجينية؟
+
+100
+00:07:12,600 --> 00:07:17,320
+أدنين، جوانين، سايتوسين وثيامين، مظبوط؟ ثيامين
+
+101
+00:07:17,320 --> 00:07:24,260
+اللي هم ال CG و الAT الآن ال DNA polymerase يفترض
+
+102
+00:07:24,260 --> 00:07:27,980
+لما بيعمل replication لل DNA بياخد القاعدة و بصفها
+
+103
+00:07:27,980 --> 00:07:32,420
+ع جبال القاعدة، قاعدة ع جبال القاعدةالان لو لجأ في
+
+104
+00:07:32,420 --> 00:07:37,720
+طريقه نوكليوتايد Analog Analog يعني شبيه هياخدها
+
+105
+00:07:37,720 --> 00:07:39,920
+مش هيقدر تميز بين ال نوكليوتايد و بين ال
+
+106
+00:07:39,920 --> 00:07:43,760
+نوكليوتايد Analog بياخدها و بيركبها على الشريط
+
+107
+00:07:43,760 --> 00:07:50,460
+بتركب المشكلة بيبقى اللي مابدوش يكمل اي نوكليوتايد
+
+108
+00:07:50,460 --> 00:07:54,160
+جديدة مابتركبش مع ال نوكليوتايد Analog اللي جابلها
+
+109
+00:07:54,160 --> 00:07:58,980
+وبالتالي سيتوقف تصنيع مين؟الـ DNA، إذا الـ
+
+110
+00:07:58,980 --> 00:08:02,140
+Nucleotide Analogue أو الـ Nucleoside Analogue هي
+
+111
+00:08:02,140 --> 00:08:06,720
+وسيلة لخداع الـ DNA أو الـ RNA Polymerase وبتالي
+
+112
+00:08:06,720 --> 00:08:10,940
+إيقاف تصنيع إما الـ DNA أو الـ RNA وهذه وسيلة
+
+113
+00:08:10,940 --> 00:08:14,720
+الحقيقة مستخدمة في علاج الفيروسات ومستخدمة أيضا في
+
+114
+00:08:14,720 --> 00:08:17,580
+علاج السرطانات Nucleotide Analogues
+
+115
+00:08:20,210 --> 00:08:23,430
+قُلنا لكوا الacyclovir الacyclovir مشهور في هذا
+
+116
+00:08:23,430 --> 00:08:26,690
+الموضوع وممكن أشهر اسم تجاري اللى اسمه zoovorax
+
+117
+00:08:26,690 --> 00:08:30,890
+zoovorax هو عبارة عن برهام أصبع برهام صغير و
+
+118
+00:08:30,890 --> 00:08:37,830
+تكلفته عالية وكفاءته ليست يعني بالقدر المتوقع إذا
+
+119
+00:08:37,830 --> 00:08:41,630
+ظهر ال blister اللى هى اللى قلنا عنها ال physical
+
+120
+00:08:41,630 --> 00:08:49,370
+تمام إذا ظهرت فليس له أي فايدة ليش؟لأنه already ال
+
+121
+00:08:49,370 --> 00:08:54,610
+virus تكاثر ووصل لمرحلة تبعه ال maximum و هو أصلا
+
+122
+00:08:54,610 --> 00:08:59,250
+بدأ بالانحصار بشكل طبيعي من المناعة الموجودة في
+
+123
+00:08:59,250 --> 00:09:05,830
+جسم الإنسان لكن عند بداية الظهور أو إذا كان جهاز
+
+124
+00:09:05,830 --> 00:09:09,720
+المناعة تبع الإنسان ضعيف جداالأساكلوفير قد يساعد
+
+125
+00:09:09,720 --> 00:09:12,880
+وانقروا إلى الجملة ايش بتقول الجملة هنا it
+
+126
+00:09:12,880 --> 00:09:16,020
+shortens the duration ايش يعني shorten the
+
+127
+00:09:16,020 --> 00:09:21,240
+duration بتقصر الفترة زمني بدل ما هي أسبوع بتصير
+
+128
+00:09:21,240 --> 00:09:27,090
+أربعتية مثلا امام؟بتقصر إذا ال duration ممكن تعمل
+
+129
+00:09:27,090 --> 00:09:34,490
+تقليل من عملية إفراز الفيروس، يعني يكون أقل
+
+130
+00:09:34,490 --> 00:09:41,150
+مواديا، الإنسان مايكون أيش موادي بشكل كبير هذا مين
+
+131
+00:09:41,150 --> 00:09:47,380
+الacyclovir؟ يبقى الacyclovirمن مزياء أنه بيقصر
+
+132
+00:09:47,380 --> 00:09:54,180
+فترة المرض و بيقلل من جنة إفراز الفيروس لكن للأسف
+
+133
+00:09:54,180 --> 00:10:01,480
+حتى الفيروسات كما البكتيريا كما خلايانا لما بتعاند
+
+134
+00:10:01,480 --> 00:10:06,180
+علاجات السرطانات يعني بتصير resistant فالفيروسات
+
+135
+00:10:06,180 --> 00:10:10,740
+أيضا لديها المقدرة لتعمل resistant ل .. اللي هو ال
+
+136
+00:10:10,740 --> 00:10:17,310
+antiviralsويمكن الـ Herb Simplex Type I و Type II
+
+137
+00:10:17,310 --> 00:10:21,790
+و Varicella Zoster، التلات الأولانين هدولة هم أقل
+
+138
+00:10:21,790 --> 00:10:28,530
+المجموعة مقاومة للacyclovir لكن عندنا الـCMV على
+
+139
+00:10:28,530 --> 00:10:31,370
+سبيل المثال الـCytomegalovirus هذا مقاوم
+
+140
+00:10:31,370 --> 00:10:36,770
+للacyclovir بشكل كبير جدا، إذن بدنا نعرف إنه حتى
+
+141
+00:10:36,770 --> 00:10:39,930
+قدرة الفيروسات على المقاومة تختلف من فيروس إلى
+
+142
+00:10:39,930 --> 00:10:46,760
+فيروس كما البكتيريا بالضبطفي حال انه وجهتنا حالة
+
+143
+00:10:46,760 --> 00:10:51,560
+من acyclovir-resistant HSV اللي هو Herpes Simplex
+
+144
+00:10:51,560 --> 00:10:56,380
+Virus ممكن نستخدم another drug اسمه Foscarnet
+
+145
+00:11:01,550 --> 00:11:05,690
+أحنا قلنا قبل المحاضرة الماضية أنه herpes simplex
+
+146
+00:11:05,690 --> 00:11:09,810
+type 1 can cause keratitis مظبوط وقلنا لكوا ال
+
+147
+00:11:09,810 --> 00:11:14,170
+keratitis في العين يعني العين عضو حساس وممكن يؤذى
+
+148
+00:11:14,170 --> 00:11:17,990
+بشكل كبير وبتالي في مجموعة من العقاقير اللتي ممكن
+
+149
+00:11:17,990 --> 00:11:24,250
+أن تستخدم مثل trifloridin و Peniciclovir فاكرين
+
+150
+00:11:24,250 --> 00:11:29,810
+البنسالين البنسالين كان هو ال natural moleculeأول
+
+151
+00:11:29,810 --> 00:11:34,450
+موليكيوم من ال antibiotics بعدين أخدوا علماء ال
+
+152
+00:11:34,450 --> 00:11:38,810
+organic chemistry و بدوا يحوروا فيه ديفله chlorine
+
+153
+00:11:38,810 --> 00:11:43,050
+ديفله fluor ديفله مش عارف group methyl وصار عندنا
+
+154
+00:11:43,050 --> 00:11:47,430
+مجموعة كبيرة من ال antibiotics مشتقة أصلا من مين؟
+
+155
+00:11:47,430 --> 00:11:51,590
+من ال penicillin زي مثلا ال ambicillin زي ال
+
+156
+00:11:51,590 --> 00:11:55,110
+amoxicillin دي ال methicillin نافيسيلين كلها دي
+
+157
+00:11:55,110 --> 00:11:58,540
+مشتقات من مين؟ من ال penicillinأيضا الacyclovir
+
+158
+00:11:58,540 --> 00:12:03,600
+كان مركّب ومش طبيعي طبعا، مركّب لكن صار عليه
+
+159
+00:12:03,600 --> 00:12:07,880
+تحويرات متنوعة ومختلفة، والحقيقة أن هذه التحويرات
+
+160
+00:12:07,880 --> 00:12:11,960
+أثبت البعض منها أنه أفضل من مين من الجزء الأم اللي
+
+161
+00:12:11,960 --> 00:12:18,110
+هو الacyclovir، زي مثلا بنسيكلوفيرفي كمان دوكاسنول
+
+162
+00:12:18,110 --> 00:12:23,490
+وهو عبارة عن long chain saturated alcohol وبيستخدم
+
+163
+00:12:23,490 --> 00:12:30,730
+لعلاج ال herpes simplex type 1 في العين ما زلنا في
+
+164
+00:12:30,730 --> 00:12:34,590
+treatment و في ال herpes simplex type 2 اللي هو ال
+
+165
+00:12:34,590 --> 00:12:39,500
+genital herpes ممكن نستخدم valacyclovirو فام
+
+166
+00:12:39,500 --> 00:12:43,880
+سيكلوفير او فام سيكلوفير تمام فام سيكلوفير و فالا
+
+167
+00:12:43,880 --> 00:12:47,540
+سايكلوفير تتضايقوش من الأسماء كتير لإنه في الآخر
+
+168
+00:12:47,540 --> 00:12:51,360
+كلهم سايكلوفير اضيفوا المقطع قطع الاسمين و ان شاء
+
+169
+00:12:51,360 --> 00:12:54,040
+الله هيكونوا سهلين بإذن الله كمان مرة فالا
+
+170
+00:12:54,040 --> 00:12:59,460
+سايكلوفير و فام سيكلوفير كلا هما بيساعدوا على إنه
+
+171
+00:12:59,460 --> 00:13:02,280
+يعملوا suppression لل recurrence of infection
+
+172
+00:13:02,280 --> 00:13:06,650
+عارفين شهية recurrence؟يعني إعادة اللي هو ال ..مش
+
+173
+00:13:06,650 --> 00:13:10,410
+هنقولنا latent infection و بعدين reactivation ال
+
+174
+00:13:10,410 --> 00:13:15,750
+reactivation هو ال recurrence نفسه الان احنا ذكرنا
+
+175
+00:13:15,750 --> 00:13:20,130
+مجموعة من العقاقير ذكرنا Cyclovere ذكرنا Foscarnet
+
+176
+00:13:20,130 --> 00:13:25,990
+ذكرنا قبل قليل Velacyclovere و Velacyclovere و ال
+
+177
+00:13:25,990 --> 00:13:29,650
+.. اللي جابلها كانت اللي هي ال .. ال trifluoridine
+
+178
+00:13:29,650 --> 00:13:34,790
+و البنسيكلوفير و الدوكاسينولولا واحد من هذه
+
+179
+00:13:34,790 --> 00:13:40,230
+العقاقير لديه المقدر على ان يتعامل مع اللي تنسى
+
+180
+00:13:41,340 --> 00:13:46,660
+يعني احنا بنعالج الأعراب، بنعالج الفيروس اللي خارج
+
+181
+00:13:46,660 --> 00:13:52,860
+الخلايا، لكن ليس لدينا لحد الآن أي قدرة على إخراج
+
+182
+00:13:52,860 --> 00:13:57,000
+اللي تنسي اللي موجود في الخلايا، وانا اشرحتلكم
+
+183
+00:13:57,000 --> 00:14:01,120
+المرة الماضية كيف لهذه الفيروسات أن تبقى كامنة
+
+184
+00:14:01,120 --> 00:14:06,580
+داخل الخلايا، مين بتذكر؟السيتو بلازم اللي انا
+
+185
+00:14:06,580 --> 00:14:10,140
+بقوله ده في الستو بلازم طبعا مش كلهم .. مش كلهم
+
+186
+00:14:10,140 --> 00:14:14,280
+بيشتغلوا نفس القالية لكن وجودهم في الستو بلازم لو
+
+187
+00:14:14,280 --> 00:14:17,960
+جلنا one copy .. one copy كان بنقول بسيطة ايه
+
+188
+00:14:17,960 --> 00:14:20,500
+بنضحك على جهاز ال .. على ال .. على الفيروس خلنا
+
+189
+00:14:20,500 --> 00:14:24,040
+نعمل shutdown جهاز المناعة نطفى جهاز المناعة ونقول
+
+190
+00:14:24,040 --> 00:14:28,600
+للفيروسات اللي بقوله ده اطلعي تمام؟ ثمنعيد تشغيل
+
+191
+00:14:28,600 --> 00:14:32,220
+الجهاز المنها، كان قاضينا على الفيروس، لكن غالبا
+
+192
+00:14:32,220 --> 00:14:35,900
+الفيروس بيكون داخل الخلايا in multiple copies،
+
+193
+00:14:35,900 --> 00:14:39,320
+يعني ال DNA تبعه مش لسخة واحدة، مجموعة، ولما يصير
+
+194
+00:14:39,320 --> 00:14:44,780
+reactivation جزء منها بيبقىوصل الصورة بمعنى انه
+
+195
+00:14:44,780 --> 00:14:49,280
+بيغامرش بكل ال copies اللي موجودة فيه وانا قبل
+
+196
+00:14:49,280 --> 00:14:52,980
+قليل بقولكوا انه 80% او 90% من سكان العالم محتوية
+
+197
+00:14:52,980 --> 00:14:56,860
+على الفيروس يبدو ان احنا viruses بتمشي على الأرض
+
+198
+00:14:56,860 --> 00:15:02,500
+ولا ليش رأيكم؟ يعني عندنا CMV وعندنا Herpes
+
+199
+00:15:02,500 --> 00:15:08,480
+Simplex Type 1 وعندنا ..كمان معظمنا أصيب بيه ال
+
+200
+00:15:08,480 --> 00:15:13,440
+chickenpox فالفلسفة زوستر هيكون موجودة حتى
+
+201
+00:15:13,440 --> 00:15:16,880
+بالإضافة إلى فيروسات قد لا نعلم عنها شيئا والحقيقة
+
+202
+00:15:16,880 --> 00:15:19,360
+أن العلماء كشفوا أن جزء كبير من الجينوم تبقى
+
+203
+00:15:19,360 --> 00:15:25,100
+الإنسان هو عبارة عن ال genome لفيروس يعني أو على
+
+204
+00:15:25,100 --> 00:15:29,000
+الأقل بيشبه اللي هو ال genome تبقى فيروس فقد يكون
+
+205
+00:15:29,000 --> 00:15:34,120
+لها دور في أجسامنا ونحن لا ندري بعدوطبعا انا هقول
+
+206
+00:15:34,120 --> 00:15:38,460
+دايما انه مانجفلش ده دماغاتنا على انه ايش دخل
+
+207
+00:15:38,460 --> 00:15:41,380
+الفيروسات فينا، ايش دخل البكتيريا فينا، هي نشوفنا
+
+208
+00:15:41,380 --> 00:15:45,600
+ان ال human microbiome ال human microbiome اللي هو
+
+209
+00:15:45,600 --> 00:15:48,620
+النبيت الميكروبي اللي مولود في أجسامنا، في أمعانا
+
+210
+00:15:49,110 --> 00:15:53,190
+طلع له دور واعتبره العلماء كأنه عضو زيه زي الكبد
+
+211
+00:15:53,190 --> 00:15:57,550
+زيه زي الكيليا اللي هو دور مهم جدا ويعتقد ان معظم
+
+212
+00:15:57,550 --> 00:16:03,410
+الأمراض العصر من الضغط والسكر والشرين والقلب ناتجة
+
+213
+00:16:03,410 --> 00:16:07,350
+عن الاعتلال اللي موجود في ال normal microbiota فقد
+
+214
+00:16:07,350 --> 00:16:11,410
+يكون هناك أدوار محتملة للفيروسات في تكويننا ونحن
+
+215
+00:16:11,410 --> 00:16:18,480
+لا ندري بعدبقولنا اللي تنسى اللي لا يوجد إمكانية
+
+216
+00:16:18,480 --> 00:16:24,320
+لتخلص منه في الوقت الحاضر Prophylactic long term
+
+217
+00:16:24,320 --> 00:16:28,580
+administration of ايش معنى long term يعني لفترات
+
+218
+00:16:28,580 --> 00:16:32,120
+ممتدة و طويلة a cyclovere و لا a cyclovere و
+
+219
+00:16:32,120 --> 00:16:35,680
+فمcyclovere can suppress clinical recurrences زي
+
+220
+00:16:35,680 --> 00:16:42,420
+ما ذكرنا قبل قليل ال prevention involvesavoid in
+
+221
+00:16:42,420 --> 00:16:47,140
+contact with vesicular lesions or ulcers طبعا ال
+
+222
+00:16:47,140 --> 00:16:51,420
+ulcer و ال vesicular lesion هاتفقنا من المحاضرة
+
+223
+00:16:51,420 --> 00:16:56,480
+الماضية انه مليئ بالفيروس مليئ بالفيروس إذا إذا
+
+224
+00:16:56,480 --> 00:17:02,040
+شفنا lesion تمام نبتعد عنها الآن المشكلة وين
+
+225
+00:17:02,040 --> 00:17:06,980
+المشكلة لو هالكلام صحيح كان نص ال كان معظم الناس
+
+226
+00:17:06,980 --> 00:17:12,900
+ما أصيبتشلكن واضح ان الفيروس ينتقل حتى في ادم وجود
+
+227
+00:17:12,900 --> 00:17:17,700
+ال Legion و ال ulcer فموضوع ال prevention في هذا
+
+228
+00:17:17,700 --> 00:17:22,220
+الحالة شيء يعني يعتبر ضرب من الخيال لان احنا ما
+
+229
+00:17:22,220 --> 00:17:26,460
+بنعرف الأشخاص اللي حاملين او اللي بيفرزوا هذا
+
+230
+00:17:26,460 --> 00:17:32,780
+الفيروس الامهات اللي عندهم genital herpes او
+
+231
+00:17:32,780 --> 00:17:39,180
+herpes simplex type 2 و حوامل يمكنيعني تجنيب
+
+232
+00:17:39,180 --> 00:17:43,140
+المولود المرور عبر قناة الولادة من خلال عملية
+
+233
+00:17:43,140 --> 00:17:48,460
+بيصري أو caesarean section الفيروس الثالث في
+
+234
+00:17:48,460 --> 00:17:51,640
+السلسلة اللي هو الbaricella zoster virus أيضا من
+
+235
+00:17:51,640 --> 00:17:55,100
+الفيروسات الشهيرة والتي لها تأثيرات يعني
+
+236
+00:17:55,100 --> 00:17:57,040
+devastating على البشرية
+
+237
+00:17:59,270 --> 00:18:03,070
+لكم أن تتخيلوا أن هذا الفيروس .. هذا الفيروس كان
+
+238
+00:18:03,070 --> 00:18:07,950
+أكثر الفيروسات قبل 2001 من الفيروسات اللي بيسموها
+
+239
+00:18:07,950 --> 00:18:13,670
+notifiable diseases إيش يعني notifiable diseases؟
+
+240
+00:18:13,670 --> 00:18:17,050
+يجب الإبلاغ عنها .. يجب الإبلاغ عنها .. إيش يعني
+
+241
+00:18:17,050 --> 00:18:21,810
+يجب الإبلاغ عنها؟ الآن في فيروس مثلا Hepatitis B
+
+242
+00:18:21,810 --> 00:18:26,010
+أو C وفي Entamoeba Hostilitica وفي sore throat
+
+243
+00:18:26,010 --> 00:18:30,660
+اللي هو التهاب اللواز على سبيل المثالمين منهم بدنا
+
+244
+00:18:30,660 --> 00:18:36,060
+نبلغ عنه للوزارة الصحة الفلسطينية عشان في أخر
+
+245
+00:18:36,060 --> 00:18:39,940
+السنة اطلع التقرير تبعها و اتبع 2016 طلع و أنا مش
+
+246
+00:18:39,940 --> 00:18:42,540
+عارف على أي مجموعة اتحطته والله على ال essential
+
+247
+00:18:42,540 --> 00:18:45,260
+medical microbiology وانتوا اظنيني اربع فيه ولا لا
+
+248
+00:18:46,020 --> 00:18:49,440
+في ال medical microbiology التقرير موجود تغير 2016
+
+249
+00:18:49,440 --> 00:18:53,060
+و كويس انكوا تطلعوا عليه تحفظوش اشي اتطلعوا عليه
+
+250
+00:18:53,060 --> 00:18:56,800
+بس شوفوا من الأمراض اللي احنا بالفعل بندور عليها
+
+251
+00:18:56,800 --> 00:19:00,560
+كلمة بندور عليها هي notifiable في حاجة اسمها
+
+252
+00:19:00,560 --> 00:19:04,000
+nationally notifiable disease يعني على المستوى
+
+253
+00:19:04,000 --> 00:19:07,980
+المحلي القومي وفي حاجة اسمها internationally
+
+254
+00:19:07,980 --> 00:19:13,660
+notifiable disease يعني مثلاطعون مدغشقر حالة واحدة
+
+255
+00:19:13,660 --> 00:19:16,740
+صارت من الطعون في أي مكان في الدنيا لازم مُنظمة
+
+256
+00:19:16,740 --> 00:19:18,800
+الصحة العالمية تعرف عنه هذا اسمه internationally
+
+257
+00:19:18,800 --> 00:19:24,200
+notifiable disease الآن ال chickenpox هو
+
+258
+00:19:24,200 --> 00:19:27,040
+notifiable disease يجب الإبلاغ عنه سواء محلي أو
+
+259
+00:19:27,040 --> 00:19:32,980
+دوليفكان هو قبل 2001 هو الأشهر على الإطلاق في
+
+260
+00:19:32,980 --> 00:19:35,960
+الولايات المتحدة الأمريكية بمعنى أنه هو الأكثر
+
+261
+00:19:35,960 --> 00:19:39,700
+عددا هو الأكثر عددا طب مش اللي اختلف بين 2001 و
+
+262
+00:19:39,700 --> 00:19:44,080
+بعد ذلك هو إدخال ال vaccine للخدمة إدخال ال
+
+263
+00:19:44,080 --> 00:19:48,380
+vaccine للخدمة ما زال ل chickenpox يحدث حتى في
+
+264
+00:19:48,380 --> 00:19:53,980
+وجود ال vaccine لكن أقل حدة أقل حدة المرض بيكون من
+
+265
+00:19:53,980 --> 00:20:00,500
+ما لو لم يكن هناك تطيين البدءبنفهم أول حاجة معلومة
+
+266
+00:20:00,500 --> 00:20:04,000
+مهمة جدا ان ال Varicella Zoster is only one virus
+
+267
+00:20:04,000 --> 00:20:08,660
+يعني صحيح هما two diseases لكن one virus مايفكرش
+
+268
+00:20:08,660 --> 00:20:12,620
+انه الفيروس بيكون بشكل و بعدين بيصير بشكل تاني
+
+269
+00:20:12,620 --> 00:20:19,180
+الشكل هو هو لم يتغير لكن بيسبب two conditions ال
+
+270
+00:20:19,180 --> 00:20:22,640
+condition الأول هو ال chickenpox اللي بتعرفوه و ال
+
+271
+00:20:22,640 --> 00:20:26,700
+condition التاني اللي هو ال Zoster ليش اختلف الأول
+
+272
+00:20:26,700 --> 00:20:33,140
+عن التاني؟بدا نفسره من الآن و نقولكوا انه في
+
+273
+00:20:33,140 --> 00:20:35,460
+البداية في ال primary infection there is no
+
+274
+00:20:35,460 --> 00:20:39,600
+immunity against this disease و اتذكروا كويس
+
+275
+00:20:39,600 --> 00:20:43,960
+الكلام اللي بدي احكيه لأنه حيزننا بعد دقايق no
+
+276
+00:20:43,960 --> 00:20:48,140
+immunity في الأطفال غالبا فبالتالي بيصير rashes في
+
+277
+00:20:48,140 --> 00:20:54,760
+كل وين في كل الجسم في كل الجسم طيب ال zoster فقط
+
+278
+00:20:54,760 --> 00:20:58,770
+في منطقة محددةو المنطقة المحددة .. طبعا الحزام
+
+279
+00:20:58,770 --> 00:21:02,350
+بالعربي ما يسميه الحزام الناري حزام لإنه بيجي على
+
+280
+00:21:02,350 --> 00:21:06,410
+شكل منطقة يعني عاملة زي الحزام localized متموضعة
+
+281
+00:21:06,410 --> 00:21:10,430
+تمام؟ سواء كان في الوجه في الصدر أو في الكتف أو في
+
+282
+00:21:10,430 --> 00:21:14,410
+الظهر لإن اللي تنسي بيكون في العصب العصب بيكون
+
+283
+00:21:14,410 --> 00:21:19,910
+طويل عندما يستشعر الفيروس بضعف المناع بيخرج .. وين
+
+284
+00:21:19,910 --> 00:21:25,990
+بده يخرج؟ بيخرج مقابل ال .. ال .. مين؟ العصب تبعه
+
+285
+00:21:27,170 --> 00:21:31,670
+بيخرج مقابل العصب وبيعمل infection هو سيحاول أن
+
+286
+00:21:31,670 --> 00:21:36,150
+يذهب إلى كل أنحاء البسم لكن لإنه في antibodies
+
+287
+00:21:36,150 --> 00:21:40,930
+بتعمل neutralization من كل البسم ففقط بيذهب في
+
+288
+00:21:40,930 --> 00:21:45,710
+المكان المقابل للعصب إذا اختلف الأمر لإنه إيش
+
+289
+00:21:45,710 --> 00:21:49,630
+قلنا؟ قلنا إنه كان فيه بالأول مافيش مناعة خالص و
+
+290
+00:21:49,630 --> 00:21:53,330
+بعدين في المرحلة التانية كان فيه مناعة فهو فقط عمل
+
+291
+00:21:53,330 --> 00:21:57,430
+localized infectionطب في معلومة تانية قبل ما نبدأ
+
+292
+00:21:57,430 --> 00:22:01,830
+سرد المعلومات اللي موجودة في ال slides عندما يصاب
+
+293
+00:22:01,830 --> 00:22:06,310
+الطفل بتكون الإصابة طبعته خفيفة لكن لما بيصاب
+
+294
+00:22:06,310 --> 00:22:09,350
+الكبار حكينا فيها دي؟ حكينا فيها يا جماعة الحكي
+
+295
+00:22:09,350 --> 00:22:13,510
+مافيش داعي عنه مافيش داعي انه ان نكرر الكلام بس
+
+296
+00:22:13,510 --> 00:22:17,890
+هذه برضه قضية مهمة ان نعرف انه ال .. ال .. ال ..
+
+297
+00:22:18,620 --> 00:22:21,560
+الـ Immunopathogenesis اللي شرحناها سابقاً، إله
+
+298
+00:22:21,560 --> 00:22:26,700
+بالفعل تأثير كبير على الإسم، إذا single serotype،
+
+299
+00:22:26,700 --> 00:22:30,360
+similar to other viruses, to other herpes viruses،
+
+300
+00:22:30,360 --> 00:22:35,580
+antigenically distinct، متميز عن باقي المجموعة
+
+301
+00:22:40,140 --> 00:22:43,980
+بينتقل أيضًا عن طريق الـ Respiratory droplets وهو
+
+302
+00:22:43,980 --> 00:22:49,900
+عبارة عن مرض مؤدي جدًا كلمة contagious يعني مرض
+
+303
+00:22:49,900 --> 00:22:55,170
+مؤدي ومؤدي جدًاوهو من أمراض الطفولة يعني غالبا
+
+304
+00:22:55,170 --> 00:22:59,330
+بيحصل فيه الأطفال more than 90% of people in the
+
+305
+00:22:59,330 --> 00:23:02,110
+United States have antibodies by the age of 10
+
+306
+00:23:02,110 --> 00:23:06,890
+years عشر سنوات بيكون تسعين بالمئة من الناس عندهم
+
+307
+00:23:06,890 --> 00:23:11,690
+antibody دليل علاش على أنهم تعرضوا لهذا ال virus
+
+308
+00:23:11,690 --> 00:23:18,250
+رقم ضخم جدابريسيلا و cars worldwide عالميا تحدث مش
+
+309
+00:23:18,250 --> 00:23:22,490
+بس في الوقت المتحدة قبل ال 2001 زي ما ذكرنا كان ال
+
+310
+00:23:22,490 --> 00:23:25,090
+chickenpox هو اعلى ال notifiable disease في
+
+311
+00:23:25,090 --> 00:23:29,750
+الولايات المتحدة لكن الاستخدام الواسع ده ال
+
+312
+00:23:29,750 --> 00:23:32,410
+vaccine خفض من هذه الاعداد
+
+313
+00:23:36,230 --> 00:23:38,950
+كل ال physicals اللي موجودة سواء كان في ال chicken
+
+314
+00:23:38,950 --> 00:23:43,130
+box أو في الزوستر موجود فيها الفيروس، ال physicals
+
+315
+00:23:43,130 --> 00:23:45,390
+موجود فيها الفيروس و الفيروس في هذه الحالة بيكون
+
+316
+00:23:45,390 --> 00:23:49,070
+معضي جدا و أنا ذكرت كلمة contagious، contagious
+
+317
+00:23:49,070 --> 00:23:50,170
+معناها معض
+
+318
+00:23:53,480 --> 00:23:57,140
+أحد النقاط المهمة اللي لازم نبرزها في هذا الموضوع
+
+319
+00:23:57,140 --> 00:24:03,200
+هو عندما يحدث حالة varicella أو زوستر في المستشفى
+
+320
+00:24:03,200 --> 00:24:10,160
+تعتبر حالة emergency لل infection control لماذا؟
+
+321
+00:24:10,160 --> 00:24:12,940
+دايما و أبدا بيكونوا تعرفوا أن بيئة المستشفى بيبقى
+
+322
+00:24:12,940 --> 00:24:17,690
+متميزةمتفردة لماذا بيقى متميزة و متفردة؟ لأن
+
+323
+00:24:17,690 --> 00:24:22,670
+روادها غالبا من دول المناعة المنخفضة أصلا رايحين و
+
+324
+00:24:22,670 --> 00:24:28,190
+هم مرضى وبتالي جهاز المناعة تبعهم depressed فأي
+
+325
+00:24:28,190 --> 00:24:32,670
+وجود لأي شخص مصاب بالفارسيلا أو بالزوستر سواء كان
+
+326
+00:24:32,670 --> 00:24:37,970
+من العاملين أو من المرضى should be isolatedطبعا ان
+
+327
+00:24:37,970 --> 00:24:41,070
+العاملين بيقولوا خد sick leave يعني خد إجازة مرضية
+
+328
+00:24:41,070 --> 00:24:47,190
+بينما إذا كان من المرضى يجب أن يعزل في غرفة خاصة
+
+329
+00:24:47,190 --> 00:24:52,470
+لإنه إذا لم يعزل سيسبب outbreak انتشار واسع فيه
+
+330
+00:24:52,470 --> 00:24:57,610
+لإنه كمرة ما المرضى المردين lower immunity وهذا
+
+331
+00:24:57,610 --> 00:24:59,610
+بيسبب انتشار واسع جدا
+
+332
+00:25:03,240 --> 00:25:07,900
+من أهم ال findings اللي هي ال multinucleated giant
+
+333
+00:25:07,900 --> 00:25:11,740
+cell و ال intra nuclear inclusions و بنالكوا انه
+
+334
+00:25:11,740 --> 00:25:15,340
+الفيروس بيعمل لتنسي في الدورسل روت جانجيليا و هذا
+
+335
+00:25:15,340 --> 00:25:19,320
+السبب اللي بيخليه لما يعمل زوستر يعمل في هذه
+
+336
+00:25:19,320 --> 00:25:23,920
+المناطق حاكينا هذا الكلام اللي هو انه during
+
+337
+00:25:23,920 --> 00:25:27,260
+latency الفيروس بيكون مولود في وين في الـcytoplasm
+
+338
+00:25:27,260 --> 00:25:34,190
+و مش موجود في ال nuclear أو في ال nucleusبالنسبة
+
+339
+00:25:34,190 --> 00:25:37,950
+للزوستر احنا ذكرنا الشكل تبعه هو عبارة عن physical
+
+340
+00:25:37,950 --> 00:25:42,150
+مصطفى فيه بشكل حزام لكن اما اتكلمنا عن القلم
+
+341
+00:25:42,150 --> 00:25:47,500
+المصاحب اللي هو اللغة العربيةكانت دقيقة في الوصف
+
+342
+00:25:47,500 --> 00:25:52,580
+الشكلي و في نفس الوجد كانت دقيقة في الوصف الحسي
+
+343
+00:25:52,580 --> 00:25:58,780
+لإن النار برضه ألم تمام فال ال ال ال physical اللي
+
+344
+00:25:58,780 --> 00:26:02,380
+بتظهر في ال virus اللي في ال exhaust بتكون مؤلمة
+
+345
+00:26:02,380 --> 00:26:06,300
+جدا و فيها burning sensation أو شعور بيه يعني ألم
+
+346
+00:26:06,300 --> 00:26:11,760
+شديد و قد يستمر هذا الألم إلى عدة أسابيعوقد يكون
+
+347
+00:26:11,760 --> 00:26:16,520
+Depilating كلمة Depilating يعني معيق بمعنى إنه لا
+
+348
+00:26:16,520 --> 00:26:20,940
+يستطيع الشخص أن يمارس حياته بشكل طبيعي خلال فترة
+
+349
+00:26:20,940 --> 00:26:26,180
+إصابته بيه اللي هو الزوستر إمكانية الإصابة
+
+350
+00:26:26,180 --> 00:26:30,740
+بالزوستر تزداد بازدياد الأمر يعني كل ما الإنسان
+
+351
+00:26:30,740 --> 00:26:35,220
+كبر عشان هيك نطلع على ال vaccine اللي هنشوفه كمان
+
+352
+00:26:35,220 --> 00:26:38,740
+شوية هلاج إنه ال vaccine تبقى الزوستر يعطى فوق ال
+
+353
+00:26:38,740 --> 00:26:43,190
+60وبدي من هال لما نسأل ال vaccine تفكروا ليش في
+
+354
+00:26:43,190 --> 00:26:47,990
+اتنين vaccines؟ واحد ل ال chicken box و واحد لمين؟
+
+355
+00:26:47,990 --> 00:26:53,810
+لل zoster ليش ماعملوا vaccine للتانين؟ الاصل ان هو
+
+356
+00:26:53,810 --> 00:27:03,510
+فيروس واحد صح؟ يعني عمل ايه؟ vaccine واحد ماعرفش
+
+357
+00:27:03,510 --> 00:27:04,130
+نسمع؟
+
+358
+00:27:08,400 --> 00:27:10,800
+نفس الجثة يعني، هو مش .. هو مش .. لن يتغير،
+
+359
+00:27:10,800 --> 00:27:20,140
+الفيروس لن يتغير هو ولا جهاز الملعق نقله؟ أه
+
+360
+00:27:20,140 --> 00:27:25,820
+بس ليش .. ليش عملنا اتنين مش واحد؟ لكن هو بيعمل
+
+361
+00:27:25,820 --> 00:27:29,200
+response، هو .. وعشانك .. عشانك ابناش famine اللي
+
+362
+00:27:29,200 --> 00:27:31,680
+هو ال disease، وبالتالي المفروض انه عمل response
+
+363
+00:27:37,090 --> 00:27:40,750
+يعني ال antibodies بتبدأ تنخفض فبالتالي مضطرين
+
+364
+00:27:40,750 --> 00:27:44,310
+نعطي .. نعطي زي نوع من ال booster dose جرجرعة
+
+365
+00:27:44,310 --> 00:27:47,850
+انشطية هذا امكن الكلام الأقرب و الدليل على ذلك على
+
+366
+00:27:47,850 --> 00:27:51,770
+كلامك انه كلامك دقيق هو انه نسبة الفيروس في ال
+
+367
+00:27:51,770 --> 00:27:56,910
+vaccine تبع ال zoster أعلى ب 14 مرة من نسبته في ال
+
+368
+00:27:56,910 --> 00:28:00,280
+chicken box عشان نعطيمناعة قوية أو ندعم لهذه
+
+369
+00:28:00,280 --> 00:28:04,200
+المناعة بشكل قوي لأنه على سن ستين بيكون ال
+
+370
+00:28:04,200 --> 00:28:09,980
+response بالفعل أضعف من على سن اللي هو صغير اذا
+
+371
+00:28:09,980 --> 00:28:15,960
+كمان مرة اتفقنا ان ال frequency of zoster increase
+
+372
+00:28:15,960 --> 00:28:20,560
+with ageنبدأ نتكلم عن الـ Varicella، و الـ
+
+373
+00:28:20,560 --> 00:28:22,960
+Varicella بيقولنا إنه incubation period تبعها من
+
+374
+00:28:22,960 --> 00:28:28,160
+14 إلى 21 يوم، و بيبدأ عندنا Prodromal Symptoms،
+
+375
+00:28:28,160 --> 00:28:30,320
+عارفين الـ Prodromal Symptoms اللي قلنا عنها؟ اللي
+
+376
+00:28:30,320 --> 00:28:35,960
+شعر أنه بدي أمرض، ممكن يكون Non-specific Symptoms
+
+377
+00:28:36,760 --> 00:28:41,420
+بعدين بيبدأ يظهر اللي هو ال papulovascular rash و
+
+378
+00:28:41,420 --> 00:28:45,500
+ال vesicular rash عفوا و هذا ال vesicular rash
+
+379
+00:28:45,500 --> 00:28:48,440
+بيبدأ على الجذع تبع الإنسان جذع الإنسان يعني الصدر
+
+380
+00:28:48,440 --> 00:28:52,400
+و الظهر و بعدين بينتشر إلى الأطراف و إلى الوجه
+
+381
+00:28:52,400 --> 00:28:58,300
+بيكون بشكل crops يعني بشكل خلينا نقول حبيبات
+
+382
+00:28:58,300 --> 00:29:02,080
+متلاسقة مع بعضهم البعض قريبة من بعض مش متباعدة
+
+383
+00:29:02,080 --> 00:29:04,580
+بتكون بشكل قريب من بعض
+
+384
+00:29:07,940 --> 00:29:11,020
+من أشهر ال .. ال .. ال symptoms اللي هي ال itching
+
+385
+00:29:11,020 --> 00:29:15,120
+أو بيسموها pruritus ال itching يعني هو الممكن هو
+
+386
+00:29:15,120 --> 00:29:19,820
+الخطر الأساسي اللي .. اللي ممكن يعني يصاحب معظم
+
+387
+00:29:19,820 --> 00:29:23,240
+الأطفال لإن الأطفال ده المناعة الجيدة غالبا
+
+388
+00:29:23,240 --> 00:29:28,160
+بياشفوا تلقائيا لكن ال itching أو الحكا بتسبب أن
+
+389
+00:29:28,160 --> 00:29:33,440
+الطفل ممكن يجرح مكان ال physicalإذا جرح ال
+
+390
+00:29:33,440 --> 00:29:37,480
+physical غالبا بتكون إمكانية إصابتها ب secondary
+
+391
+00:29:37,480 --> 00:29:41,420
+infection من بكتيريا عالية جدا و بتترك scar ..
+
+392
+00:29:41,420 --> 00:29:46,560
+scar يعني اللي هي نضبة والحقيقة أنه لا أحد يرغب
+
+393
+00:29:46,560 --> 00:29:49,940
+بوجود نضوب لأنه الأن تتطلع على الوجه .. الوجه كله
+
+394
+00:29:49,940 --> 00:29:54,020
+مليء بال physical تمام؟ وبتالي إذا صار في حكة لذلك
+
+395
+00:29:54,020 --> 00:30:00,690
+أحد أهميعني العلاجات أنه نعطي ملطفات تمام للأطفال
+
+396
+00:30:00,690 --> 00:30:04,490
+حتى يخفف من اللي هو التهيج و الحكا عند هؤلاء
+
+397
+00:30:04,490 --> 00:30:10,790
+الأطفال الجملة
+
+398
+00:30:10,790 --> 00:30:13,850
+اللي احنا قولناكوا فسروها و طلعنا احنا بنخشينها
+
+399
+00:30:13,850 --> 00:30:17,830
+اللي هي لماذا البرسيلة في ال childhood بتكون mild
+
+400
+00:30:17,830 --> 00:30:23,310
+لكن في القضلة بتكون severeالـVaricella pneumonia
+
+401
+00:30:23,310 --> 00:30:28,530
+and encephalitis are the major rare complications،
+
+402
+00:30:28,530 --> 00:30:33,710
+كلمة rare يعني one in thousands، one in thousands،
+
+403
+00:30:33,710 --> 00:30:37,950
+rare complications occurring more often in adults،
+
+404
+00:30:37,950 --> 00:30:42,650
+طبعا فرصة ظهورها كنا في الكبار بتكون أعلى من اللي
+
+405
+00:30:42,650 --> 00:30:47,110
+هم الصغار، في نقطة مهمة جدا، غير مقتصرة على
+
+406
+00:30:47,110 --> 00:30:50,610
+الـVaricella zoster، اسمها Ray's syndrome، Ray's
+
+407
+00:30:50,610 --> 00:30:55,240
+syndrome،سمعتوا ان الاسبيرين في بعض الحالات مش
+
+408
+00:30:55,240 --> 00:31:00,540
+كويس؟ الاسبيرين في بعض الحالات مش كويس، في حالتين،
+
+409
+00:31:00,540 --> 00:31:04,280
+لما يكون الطفل عنده influenza caused by influenza
+
+410
+00:31:04,280 --> 00:31:09,620
+type B و لما يكون عنده varicella، إذا أعطينا الطفل
+
+411
+00:31:09,620 --> 00:31:15,600
+اسبيرين كخافض للحرارة، تمام؟ ممكن ينتج عنده
+
+412
+00:31:16,550 --> 00:31:19,290
+condition بنسميه هنا ليه ال syndrome كيف بينتج ال
+
+413
+00:31:19,290 --> 00:31:23,970
+condition و كيف بشتغل ال aspirin ماحدش عارف لكن
+
+414
+00:31:23,970 --> 00:31:27,910
+كنا عارفين انه بينتج عنه encephalopathy و liver
+
+415
+00:31:27,910 --> 00:31:31,490
+degeneration يعني خلل في الدماغ و خلل في وين؟ في
+
+416
+00:31:31,490 --> 00:31:34,710
+ال liver في الحالتين يعني عشانك بنقول ان ال
+
+417
+00:31:34,710 --> 00:31:39,150
+aspirin is contraindicated لا يعطى لا في حالة ال
+
+418
+00:31:39,150 --> 00:31:42,250
+barcelona zoster ولا في حالة اللي هو ال influenza
+
+419
+00:31:42,250 --> 00:31:43,270
+virus
+
+420
+00:31:46,350 --> 00:31:51,390
+Exhauster كما ذكرنا هو عبارة عن وجود painful
+
+421
+00:31:51,390 --> 00:31:56,950
+vesicles يعني مؤلمة الحوائز صارت مؤلمة along the
+
+422
+00:31:56,950 --> 00:32:00,770
+course of a sensory nerve along the course يعني
+
+423
+00:32:00,770 --> 00:32:05,390
+على طول امتداد هذا ال nerve وقلنالكوا السبب انه مش
+
+424
+00:32:05,390 --> 00:32:11,400
+لاجي مكان يهرب اليه الا المقابل تبع هذا ال nerveفي
+
+425
+00:32:11,400 --> 00:32:16,780
+condition بيسموه post-zoster neuralgia أو اعتلال
+
+426
+00:32:16,780 --> 00:32:23,420
+عصبي ما بعد الـ zoster واسم تاني له post-herpetic
+
+427
+00:32:23,420 --> 00:32:29,190
+neuralgiaليش post-herpetic؟ لأنه أصلا الـ Zoster
+
+428
+00:32:29,190 --> 00:32:32,570
+Virus أو الـ Varicella Zoster Virus هو أحد أعضاء
+
+429
+00:32:32,570 --> 00:32:36,790
+من ال Herpes Virus family، تنسوش الكلام هذا، احنا
+
+430
+00:32:36,790 --> 00:32:39,730
+صحيح بنناقش في Herpes Simplex Type I و Type II و
+
+431
+00:32:39,730 --> 00:32:43,870
+Varicella لكن كلهم تحت عيلة اسمها Herpes Virus
+
+432
+00:32:43,870 --> 00:32:48,510
+Family، برضه هذا ال condition can be debilitating
+
+433
+00:32:48,510 --> 00:32:53,910
+و قلنا ممكن يكون مؤيق لأداء وظيفة الإنسانمن أشهر
+
+434
+00:32:53,910 --> 00:32:57,510
+ومن أخطر ال complications اللي ممكن تحدث جونها
+
+435
+00:32:57,510 --> 00:33:00,630
+ويسموها life threatening infection في
+
+436
+00:33:00,630 --> 00:33:05,130
+الفارسيلازوستر اللي هي pneumonia وهذه سيئة للغاية
+
+437
+00:33:05,130 --> 00:33:12,910
+ال lab diagnosis في الفارسيلازوستر غالبا يعني زمان
+
+438
+00:33:12,910 --> 00:33:16,950
+ماكانوش ينتبهوا لل laboratory diagnosis ليش؟لأن ال
+
+439
+00:33:16,950 --> 00:33:21,630
+clinical picture الصورة السريرية للمرض سواء كان في
+
+440
+00:33:21,630 --> 00:33:25,450
+ال primary infection اللي هي ال Varicella أو في ال
+
+441
+00:33:25,450 --> 00:33:29,790
+.. ال .. ال reactivation اللي هو ال Zoster ال
+
+442
+00:33:29,790 --> 00:33:32,770
+clinical picture كانت واضحة جدا ولا زالت واضحة جدا
+
+443
+00:33:32,770 --> 00:33:38,050
+لكن بيكونوا تعرفوا أنه من بعد 2001 نسبة الإصابة
+
+444
+00:33:38,050 --> 00:33:42,900
+بالمرض أشملها انخفضتانخفاض نسبة الإصابة بالمرض
+
+445
+00:33:42,900 --> 00:33:47,380
+يجعل من الأطباء أقل خبرة في تشخيص المرض عندما يرى
+
+446
+00:33:47,380 --> 00:33:50,680
+الطبيب مرارا او تكرارا نفس الصورة بيصير الأمر
+
+447
+00:33:50,680 --> 00:33:56,440
+بالنسبة له سهل فال diagnosis هو ضرورة من الضروريات
+
+448
+00:33:56,440 --> 00:34:01,640
+واحدة منهم نرجع لمين؟ لتزناق سمير تزناق سمير
+
+449
+00:34:01,640 --> 00:34:04,240
+شوفناها في herpes simplex type 1 وtype 2
+
+450
+00:34:04,240 --> 00:34:08,910
+وhyperbarisella zosterوجود الـ Multinucleated
+
+451
+00:34:08,910 --> 00:34:15,050
+Giant Cell برضه يعني عامل مساعد وأيضا يمكن زراعة
+
+452
+00:34:15,050 --> 00:34:19,610
+أو استزراع الفيروس على Cell Culture وممكن نتعرف
+
+453
+00:34:19,610 --> 00:34:23,430
+على الفيروس من خلال اللي هو Specific Anti Serum طب
+
+454
+00:34:23,430 --> 00:34:27,570
+احنا قلنا قبل قليل بنزرع عشان الفيروس يكون كميته
+
+455
+00:34:27,570 --> 00:34:31,410
+كبيرة كافية لإجراء فحوصات من ضمن هذه الفحوصات ان
+
+456
+00:34:31,410 --> 00:34:35,590
+نشوف اللي هو Specific Anti Body Agglutination Test
+
+457
+00:34:36,500 --> 00:34:42,180
+أيضا الارتفاع في تركيز ال antibody في رسم الإنسان
+
+458
+00:34:42,180 --> 00:34:48,400
+هو كويس لتشخيص ال varicella لكن ليس له قيمة في
+
+459
+00:34:48,400 --> 00:34:52,900
+تشخيص مين ال zoster أعتقد أنه السبب واضح أنه أصلا
+
+460
+00:34:52,900 --> 00:34:57,680
+بيصير فينا ارتفاع في ال antibody بعد درجة من
+
+461
+00:34:57,680 --> 00:35:00,020
+العلاجات زي ما احنا قلنا بالأول تشخيص كان بدون
+
+462
+00:35:00,020 --> 00:35:05,450
+تشخيصمظبوط وكان كليكالي التشخيص ايضا بالنسبالى
+
+463
+00:35:05,450 --> 00:35:11,910
+العلاجات غالبا العلاج تبع ال Varicella Zoster كان
+
+464
+00:35:11,910 --> 00:35:15,970
+مش ضرورى خاصة في ال immunocompetent individuals
+
+465
+00:35:15,970 --> 00:35:18,950
+يعني الناس اللي هم معروف انه مناقتهم جيدة
+
+466
+00:35:18,950 --> 00:35:24,650
+مابنعطيهم كان علاج لكن immunocompetent
+
+467
+00:35:24,650 --> 00:35:30,140
+adults بناكلها مامي على اطفالهاالـ Immunocompetent
+
+468
+00:35:30,140 --> 00:35:32,720
+adult ما احنا قلنا لكم قبل شوية انه ال civility
+
+469
+00:35:32,720 --> 00:35:35,340
+بتكون فيه عندهم ايه؟ عالية وبالتالي هدول الناس
+
+470
+00:35:35,340 --> 00:35:39,660
+محتاجين انه هنا نخفف عنهم ممكن نستخدم اللي هو
+
+471
+00:35:39,660 --> 00:35:44,080
+الacyclovir مرة أخرى to reduce the duration and
+
+472
+00:35:44,080 --> 00:35:49,100
+civility of symptoms إذا الacyclovir علاج ليه؟ ليس
+
+473
+00:35:49,100 --> 00:35:54,460
+للقضاء على الفيروس وانما لتقليل الحدة وتخفيف المدة
+
+474
+00:35:54,460 --> 00:35:59,440
+الزمنيةيبقى الأطفال مش محتاجين علاج ال adults اللي
+
+475
+00:35:59,440 --> 00:36:02,320
+عندهم moderate او severe infection محتاجين ان احنا
+
+476
+00:36:02,320 --> 00:36:05,380
+نعطيهم acyclovir و أعرفنا ليش عشان نقصر الفترة و
+
+477
+00:36:05,380 --> 00:36:07,860
+نقلل ال severity اللي عندي لمين؟ لل
+
+478
+00:36:07,860 --> 00:36:11,660
+immunocompromised children and adults with
+
+479
+00:36:11,660 --> 00:36:15,460
+chickenpox او زوستر او disseminated disease should
+
+480
+00:36:15,460 --> 00:36:18,180
+be treated ..الان مافيش خيارة انها should be
+
+481
+00:36:18,180 --> 00:36:22,880
+treated with acyclovir طبعا فوسكرنت كمان مرة
+
+482
+00:36:22,880 --> 00:36:27,810
+يستخدم لحالات مين؟اللي هم Acyclovir-resistant
+
+483
+00:36:27,810 --> 00:36:34,050
+strains. Two drugs similar to acyclovir اللي هم
+
+484
+00:36:34,050 --> 00:36:37,610
+الفامسيكلوفير والفالاسيكلوفير وده ماروا معانا قبل
+
+485
+00:36:37,610 --> 00:36:42,790
+دقائق can be used in patients with zoster to
+
+486
+00:36:42,790 --> 00:36:47,190
+accelerate healing of the lesions فاكرين قبل برضه
+
+487
+00:36:47,190 --> 00:36:52,830
+قليل قلنا انهالزوستر قد يعني يبقى لعدة أسابيع
+
+488
+00:36:52,830 --> 00:36:57,370
+والألم المصاحب له ألم فظيع وبالتالي إذا بدنا نخفف
+
+489
+00:36:57,370 --> 00:37:00,170
+عن هدولها المرضى وخاصة في ذوي الملاعق المنخفضة
+
+490
+00:37:00,170 --> 00:37:03,950
+ممكن نعطيهم برضه العقاقير اللي قلنا عنه ال vom
+
+491
+00:37:03,950 --> 00:37:05,650
+cyclover و الvalacyclo
+
+492
+00:37:11,730 --> 00:37:16,070
+أحنا ذكرنا أن الـVelociclover و الـFemiciclover
+
+493
+00:37:16,070 --> 00:37:17,970
+بيخففوا من الأعراض
+
+494
+00:37:20,730 --> 00:37:25,990
+ثبت انه مالهمش اي تأثير على ما يسمى بال post
+
+495
+00:37:25,990 --> 00:37:30,890
+-herpetic أو post-zoster neuralgia اعطيت او ما
+
+496
+00:37:30,890 --> 00:37:34,990
+اعطيت امكانية حدوث ال post-herpetic neuralgia
+
+497
+00:37:34,990 --> 00:37:40,230
+موجودة ومرتفعة تمام؟ يعني العلاج ماأثرش على ال
+
+498
+00:37:40,230 --> 00:37:46,930
+outcome على هذا ال condition ال prevention كيف
+
+499
+00:37:46,930 --> 00:37:52,400
+بنتقل هو؟ كيف بنتقل؟مش بيقول إنها Respiratory،
+
+500
+00:37:52,400 --> 00:37:55,360
+يعني بيقول إنها Respiratory وممكن نكون عبر مين ال
+
+501
+00:37:55,360 --> 00:37:59,640
+direct contact عبر اللي هو ال vesicles. الآن لما
+
+502
+00:37:59,640 --> 00:38:03,540
+بيكون عندي vaccine، بكل فخر واعتزاز بنقول لدينا
+
+503
+00:38:03,540 --> 00:38:08,620
+vaccines، وهو هذه يعني بنحطها في مقدمات ال .. ال
+
+504
+00:38:08,620 --> 00:38:12,030
+.. ال prevention، تمام؟فالان انا فيه اندي two
+
+505
+00:38:12,030 --> 00:38:15,510
+vaccines واحد اسمه vary-vax و vary من varicella
+
+506
+00:38:15,510 --> 00:38:20,390
+والتاني zoster-vax وهذا من ايه؟ من zoster وانا
+
+507
+00:38:20,390 --> 00:38:23,670
+اعتقد انه نقشنا هذا الموضوع لماذا هناك two
+
+508
+00:38:23,670 --> 00:38:28,670
+vaccines واحد لفاريسيلا واحد لزوستر وذكرنالكوا ان
+
+509
+00:38:28,670 --> 00:38:33,550
+الفرق الأساسي بينهم هو ان ال zoster-vax بيحتوي على
+
+510
+00:38:33,550 --> 00:38:38,990
+اربعة عشر ضعف تركيز الفيروس من اللي هو ال vary-vax
+
+511
+00:38:41,050 --> 00:38:43,050
+يُعطى ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+512
+00:38:43,050 --> 00:38:43,810
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+513
+00:38:43,810 --> 00:38:45,650
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+514
+00:38:45,650 --> 00:38:45,870
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+515
+00:38:45,870 --> 00:38:52,830
+ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+516
+00:38:52,830 --> 00:38:56,590
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+517
+00:38:56,590 --> 00:38:56,610
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+518
+00:38:56,610 --> 00:38:57,710
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+519
+00:38:57,710 --> 00:38:58,070
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+520
+00:38:58,070 --> 00:38:58,670
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+521
+00:39:05,980 --> 00:39:10,500
+ليش بنختار الفئة العمري؟ هل هو يعني نوع من التنظيم
+
+522
+00:39:10,500 --> 00:39:17,200
+عشان نخلي نعمل جدول؟ ولا فيه الو scientific basis؟
+
+523
+00:39:17,200 --> 00:39:20,500
+الو scientific basis والحقيقة أنه لو دينا دورنا
+
+524
+00:39:20,500 --> 00:39:25,600
+على بتاقات التطعيم أو على أنظمة التطعيم اللي كانت
+
+525
+00:39:25,600 --> 00:39:28,660
+موجودة في فلسطين هلاجي أنها مارت بتغيرات والتغيرات
+
+526
+00:39:28,660 --> 00:39:31,280
+هذه مارت بناء على دراسات مش دراسات محلية غالبا
+
+527
+00:39:31,280 --> 00:39:39,180
+دراسات دوليةمثلا الأم اللي عندها antibody ل
+
+528
+00:39:39,180 --> 00:39:44,860
+الفارسيلة بتعطي ابنها أو بنتها هذا ال antibody لو
+
+529
+00:39:44,860 --> 00:39:49,160
+جينا نحكن الطفل هو عمره أسبوع أو شهر أو شهرين بال
+
+530
+00:39:49,160 --> 00:39:53,710
+vaccineاللي هو Serotype 1، الفاكسين هيبقى عن
+
+531
+00:39:53,710 --> 00:39:57,030
+فيروس، وانا عندي Antibody، فالـ Antibody على طول
+
+532
+00:39:57,030 --> 00:40:01,090
+بيهاجم من الفيروس، فبيقلل من كفاءة الفاكسين،
+
+533
+00:40:01,090 --> 00:40:04,450
+فبتالي لما بنختار احنا الفترات، بنعرف ايش اللي
+
+534
+00:40:04,450 --> 00:40:08,890
+ممكن يكون موجود من Antibody عند الطفل أو ماكنش
+
+535
+00:40:08,890 --> 00:40:12,710
+موجود، إذا ان هو مرة أخرى مش Hub hazard وإنما يعني
+
+536
+00:40:12,710 --> 00:40:19,010
+planned أو مخطط، لأواخد 13 سنة والزوزة الفاكسين
+
+537
+00:40:19,010 --> 00:40:24,210
+بيعطي للي فوق ال 60 سنة طبعا الجملة اللي قلناها ان
+
+538
+00:40:24,210 --> 00:40:29,350
+الفرصة بتزداد بالاصابة كلما تقدم بينا العمر هذا هو
+
+539
+00:40:29,350 --> 00:40:34,490
+السبب اللي خدعنا نتكلم عنه عمر ال 60 طيب الفاكسين
+
+540
+00:40:34,490 --> 00:40:38,830
+بيحتوي على live virus وبالتالي يجب ان يعطي للناس
+
+541
+00:40:38,830 --> 00:40:43,570
+اللي عندهم منعه منخفضة واحنا ممكن ذكرنا هذا الكلام
+
+542
+00:40:43,570 --> 00:40:48,630
+التطييم يا جماعةيجب اللي يحدث للأطفال الذين يعانون
+
+543
+00:40:48,630 --> 00:40:53,090
+من أي إصابة أو عدوة و لو كان منعته منخفضة بدنا
+
+544
+00:40:53,090 --> 00:40:58,130
+نستنى فترة واجيزة حتى تتحسن صحة الطفل حتى نعطيه ال
+
+545
+00:40:58,130 --> 00:41:02,510
+vaccine لإنه بنخاف خاصة لما اتكلمنا عن ال live
+
+546
+00:41:02,510 --> 00:41:06,590
+attenuated vaccines في ال immun compromise هذه
+
+547
+00:41:06,590 --> 00:41:11,350
+live فممكن تعمل disease عند هدول الناس وبالتالي
+
+548
+00:41:11,350 --> 00:41:17,510
+بالفعل لازم ننتبه لهذا الموضوعلو حصل و أعطينا
+
+549
+00:41:17,510 --> 00:41:22,570
+vaccine و صار disease، هل هناك حلول؟ نعم في حلول،
+
+550
+00:41:22,570 --> 00:41:26,050
+في عندنا الacyclovir و في عندنا ال varicella
+
+551
+00:41:26,050 --> 00:41:31,040
+zoster immunoglobulinsهذا immunoglobulin هذا جاهزة
+
+552
+00:41:31,040 --> 00:41:36,740
+من برا تمام عشان انكافح فيها المضاعفات اللى ممكن
+
+553
+00:41:36,740 --> 00:41:41,000
+تنشأ من ال vaccination او عند اي شخص اصلا عنده
+
+554
+00:41:41,000 --> 00:41:44,500
+مضاعفات ممكن يُعطى هذا ال immunoglobulin هذا
+
+555
+00:41:44,500 --> 00:41:47,740
+passive ولا active passive passive passive passive
+
+556
+00:41:47,740 --> 00:41:47,820
+passive passive passive passive passive passive
+
+557
+00:41:47,820 --> 00:41:50,740
+passive passive passive passive passive passive
+
+558
+00:41:50,740 --> 00:41:51,560
+passive passive passive passive passive passive
+
+559
+00:41:51,560 --> 00:41:51,600
+passive passive passive passive passive passive
+
+560
+00:41:51,600 --> 00:41:52,160
+passive passive passive passive passive passive
+
+561
+00:41:52,160 --> 00:41:52,200
+passive passive passive passive passive passive
+
+562
+00:41:52,200 --> 00:41:52,220
+passive passive passive passive passive passive
+
+563
+00:41:52,220 --> 00:41:52,240
+passive passive passive passive passive passive
+
+564
+00:41:52,240 --> 00:41:52,300
+passive passive passive passive passive passive
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU_raw.json b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..675be41634e2a57dff299c7e6003468242e5485b
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/m5hxZnYVDUU_raw.json
@@ -0,0 +1 @@
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"text": "الـ Clinical findings لـ Herpes Simplex Type 2 أن جينة الهيربز، نيوناتا الهيربز بالإضافة إلى الـ Aseptic Meningitis و أعتقد أنه تطرحنا لمصطلح Aseptic Meningitis أنه يعني الكائن المسبب غير موجود أو لا يمكن عزله بالـ Regular Techniques", "tokens": [6027, 39184, 47942, 16483, 5296, 39184, 3204, 5190, 3998, 18945, 15576, 568, 14739, 10874, 9957, 3660, 2423, 3224, 13546, 3555, 11622, 12399, 8717, 1829, 2407, 8315, 2655, 995, 2423, 3224, 13546, 3555, 11622, 20666, 28814, 11242, 31845, 3660, 30731, 2423, 39184, 1018, 5250, 299, 376, 4559, 16074, 4032, 5551, 34268, 28543, 14739, 3224, 6055, 9566, 2288, 5016, 8315, 32767, 9381, 9566, 1211, 5016, 1018, 5250, 299, 376, 4559, 16074, 14739, 3224, 37495, 22653, 33251, 16373, 1863, 9673, 35457, 3555, 32771, 13546, 3714, 29245, 23328, 34051, 20193, 7251, 43020, 6225, 11622, 43761, 20666, 39184, 45659, 8337, 4911], "avg_logprob": -0.26691364996212047, "compression_ratio": 1.4453781512605042, "no_speech_prob": 0.0, "words": [{"start": 153.26, 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Herpes Simplex Type I أو Herpes Simplex Type II و بنعمله Gem Staining و بنشوف ال Multinucleated Giant Cell أيضا في هذا السمير", "tokens": [41185, 11331, 26108, 3660, 19446, 1975, 2655, 11622, 1863, 4587, 8608, 2304, 13546, 11331, 4117, 1829, 8315, 18871, 11296, 9673, 25720, 9673, 46958, 10632, 9122, 8315, 16472, 3224, 44945, 47283, 3215, 8608, 14407, 3555, 9154, 12174, 45761, 13672, 1829, 31439, 2423, 33024, 8608, 2407, 16606, 25961, 3204, 5190, 3998, 18945, 15576, 286, 34051, 3204, 5190, 3998, 18945, 15576, 6351, 4032, 44945, 25957, 43761, 22894, 745, 3686, 4032, 44945, 8592, 38688, 2423, 14665, 259, 1311, 306, 770, 29391, 28859, 36632, 11242, 995, 8978, 23758, 2423, 38251, 13546], "avg_logprob": -0.30316091679978646, "compression_ratio": 1.5068493150684932, "no_speech_prob": 0.0, "words": [{"start": 265.21, "end": 265.43, "word": "في", "probability": 0.63916015625}, {"start": 265.43, "end": 265.67, "word": " حاجة", "probability": 0.6083984375}, {"start": 265.67, "end": 265.77, 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2145.84, "word": " symptoms", "probability": 0.88134765625}, {"start": 2145.84, "end": 2146.38, "word": " إذا", "probability": 0.41876220703125}, {"start": 2146.38, "end": 2147.34, "word": " الacyclovir", "probability": 0.929296875}, {"start": 2147.34, "end": 2148.48, "word": " علاج", "probability": 0.977783203125}, {"start": 2148.48, "end": 2148.84, "word": " ليه؟", "probability": 0.9055989583333334}, {"start": 2148.84, "end": 2149.1, "word": " ليس", "probability": 0.947998046875}, {"start": 2149.1, "end": 2149.68, "word": " للقضاء", "probability": 0.82099609375}, {"start": 2149.68, "end": 2149.9, "word": " على", "probability": 0.7314453125}, {"start": 2149.9, "end": 2150.32, "word": " الفيروس", "probability": 0.9514973958333334}, {"start": 2150.32, "end": 2150.8, "word": " وانما", "probability": 0.84375}, {"start": 2150.8, "end": 2151.8, "word": " لتقليل", "probability": 0.976171875}, {"start": 2151.8, "end": 2152.26, "word": " الحدة", "probability": 0.748779296875}, {"start": 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1.0}, {"id": 92, "seek": 220827, "start": 2185.31, "end": 2208.27, "text": "اللي هم Acyclovir-resistant strains. 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0.9892578125}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.9892578125}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.9892578125}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.9892578125}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.98974609375}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.98974609375}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.98974609375}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.98974609375}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.98974609375}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.98974609375}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.98974609375}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.990234375}, {"start": 2512.22, "end": 2512.22, "word": " 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2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 0.99072265625}, {"start": 2512.22, "end": 2512.22, "word": " passive", "probability": 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2512.3, "word": " passive", "probability": 0.98193359375}, {"start": 2512.3, "end": 2512.3, "word": " passive", "probability": 0.98291015625}, {"start": 2512.3, "end": 2512.3, "word": " passive", "probability": 0.982421875}, {"start": 2512.3, "end": 2512.3, "word": " passive", "probability": 0.9814453125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2516.4858125, "duration_after_vad": 2398.3437499999927}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/pJ5N2O6eEbM_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/pJ5N2O6eEbM_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..fcc8b821dd5d5de7fabce403ea637a55d6f1ef5f
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/pJ5N2O6eEbM_raw.srt
@@ -0,0 +1,1856 @@
+1
+00:00:21,090 --> 00:00:23,550
+بسم الله الرحمن الرحيم نكمل مع بعض عندنا كنا
+
+2
+00:00:23,550 --> 00:00:28,270
+تكلمنا عن ال replication of viruses عرفنا أنه في
+
+3
+00:00:28,270 --> 00:00:32,190
+عاملين مهمين جدا في عملية ال replicationالمادة
+
+4
+00:00:32,190 --> 00:00:36,370
+الوراثية طبيعتها يعني هل هي DNA ولا RNA؟ وطبعا إذا
+
+5
+00:00:36,370 --> 00:00:39,810
+كان DNA هل هي double-stranded ولا single-stranded؟
+
+6
+00:00:39,810 --> 00:00:44,630
+وإذا كانت RNA هل هي single-stranded ولا double
+
+7
+00:00:44,630 --> 00:00:48,890
+-stranded ولا retrovirus؟ وإذا كانت single
+
+8
+00:00:48,890 --> 00:00:52,270
+-stranded هل هي positive sense ولا negative sense؟
+
+9
+00:00:52,270 --> 00:00:54,530
+ووضحنا إيش الفرق بين ال positive وال negative؟
+
+10
+00:00:54,530 --> 00:00:58,610
+بيقولنا إن ال positive sense هو RNA جاهز إن يكون
+
+11
+00:00:59,580 --> 00:01:02,940
+messenger RNA بينما الـ negative sense it need
+
+12
+00:01:02,940 --> 00:01:07,440
+complementation أو anti-sense العامل الآخر المهم
+
+13
+00:01:07,440 --> 00:01:12,400
+جونا المكان اللي بده يتكثر فيه الفيروس هل هو ال ..
+
+14
+00:01:12,400 --> 00:01:17,240
+ال .. ال cytoplasm ولا في ال nucleus وفي عامل تالت
+
+15
+00:01:17,240 --> 00:01:21,460
+يمكن بدأنا فيه أصلا اللي هو هل الفيروس enveloped
+
+16
+00:01:21,460 --> 00:01:26,000
+ولا non enveloped وشوفنا بالفعل المرة الماضية بعض
+
+17
+00:01:26,000 --> 00:01:30,170
+النماذج من ال replicationفي الـ Attachment على سلم
+
+18
+00:01:30,170 --> 00:01:32,450
+الميثال والـ Penetration لجينا إنه في بعض
+
+19
+00:01:32,450 --> 00:01:36,470
+الفيروسات بيعمل دمج للـ cell membrane تبعها فيه
+
+20
+00:01:36,470 --> 00:01:40,330
+بالـ Endocytosis وشوفنا ال bacteriophage اللي
+
+21
+00:01:40,330 --> 00:01:44,510
+بيعمل injection للمادة الوراثية الخاصة بيه اليوم
+
+22
+00:01:44,510 --> 00:01:48,370
+بدنا نكمل ان شاء الله محاضرتنا ونتكلم على مجموعة
+
+23
+00:01:48,370 --> 00:01:54,050
+من الاستراتيجيات اللي ال .. الفيروسات الخاصة ال ..
+
+24
+00:01:54,050 --> 00:01:58,780
+ال RNA virusesكيف بتصنع mRNA الخاص فيها؟ و بدكم
+
+25
+00:01:58,780 --> 00:02:04,380
+تلاحظوا شغل انه لما احنا درسنا الخطوات العامة لل
+
+26
+00:02:04,380 --> 00:02:08,740
+replication قلنا early transcription and
+
+27
+00:02:08,740 --> 00:02:13,320
+translation و في مرحلة late transcription و
+
+28
+00:02:13,320 --> 00:02:17,370
+translation هو ال transcription ايش بيعمل؟بطلّق
+
+29
+00:02:17,370 --> 00:02:23,270
+مرنة يبقى كل الفيروسات مهتمة في مرحلة ما انها
+
+30
+00:02:23,270 --> 00:02:29,150
+تطلّق مرنة تمام؟ في عندي ال .. ال .. ال .. ال ..
+
+31
+00:02:29,150 --> 00:02:32,790
+ال viruses مثل ال poliovirus عندها single-stranded
+
+32
+00:02:32,790 --> 00:02:35,570
+RNA of positive polarity في مشكلة في ال .. في ال
+
+33
+00:02:35,570 --> 00:02:38,910
+single-stranded positive polarity RNA ماعندهاش اي
+
+34
+00:02:38,910 --> 00:02:45,130
+مشكلة ليش؟لأنه can act as a messenger RNA وغالبا
+
+35
+00:02:45,130 --> 00:02:50,510
+لا تحتاج هذه الفيروسات أصلا polymerases من خارج
+
+36
+00:02:50,510 --> 00:02:53,910
+الخلية وهذا نقطة كتير مهمة بنذكرها بعد قليل لأنها
+
+37
+00:02:53,910 --> 00:02:56,650
+تتكلم عن حاجة اسمها infectious nucleic acid ايش
+
+38
+00:02:56,650 --> 00:03:00,110
+يعني infectious nucleic acid؟ infectious nucleic
+
+39
+00:03:00,110 --> 00:03:07,370
+acid تعني أنهناك فيروسات لو أزلنا القشرة الخارجية
+
+40
+00:03:07,370 --> 00:03:12,110
+اللى هى ال envelope و ال capsid و بقى المادة اللى
+
+41
+00:03:12,110 --> 00:03:15,290
+وراتيها ال nucleic acid قد يكون هذا ال nucleic
+
+42
+00:03:15,290 --> 00:03:20,110
+acid infectious معضى متى بيكون معضى و متى بيكونش
+
+43
+00:03:20,110 --> 00:03:27,010
+معضى بيكون معضى فقط فى حالة واحدةعندما لا يحتاج
+
+44
+00:03:27,010 --> 00:03:32,770
+its own enzymes، بيحتاجش إنزيمات من ذاته، وين
+
+45
+00:03:32,770 --> 00:03:39,010
+بيلاقي إنزيماته؟ في الخلية، بينما أي فيروس بيحتاج
+
+46
+00:03:39,010 --> 00:03:44,030
+لإنزيمات الخلية، المادة الوراثية تبعته، بذاتها
+
+47
+00:03:44,030 --> 00:03:47,850
+بتكون غير موادية، فهذه نقطة كتير مهمة هتطرقلها
+
+48
+00:03:47,850 --> 00:03:52,800
+أيضا بعد قليلالـ second group ال first group كنا
+
+49
+00:03:52,800 --> 00:03:55,320
+او ال simplest اللي هي ال positive polarity زي
+
+50
+00:03:55,320 --> 00:03:57,420
+مثلا ال polyvirus و ال second group ال single
+
+51
+00:03:57,420 --> 00:04:00,100
+-stranded RNA of negative polarity وهذا كنا
+
+52
+00:04:00,100 --> 00:04:03,740
+بيستلزم الأمر اننا مالرويه كنا complementation او
+
+53
+00:04:03,740 --> 00:04:08,760
+سمناها antisense كان بودي انه نقدر نشغل ال
+
+54
+00:04:08,760 --> 00:04:11,960
+animation لكن بقيتكم ان شاء الله اليوم هحطوكم على
+
+55
+00:04:11,960 --> 00:04:16,860
+المجموعة و انتوا تتفرجوا عليها براحتكم بإذن اللهفي
+
+56
+00:04:16,860 --> 00:04:21,480
+كمان كتجوري جديد of negative polarity اللي هو زي
+
+57
+00:04:21,480 --> 00:04:26,540
+ال misel virus ال paramioxi و ال rabies virus و
+
+58
+00:04:26,540 --> 00:04:30,440
+اللي عندهم single piece فقط من المادة الوراثية و
+
+59
+00:04:30,440 --> 00:04:34,640
+هنقول إنه هناك بعض الفيروسات المادة الوراثية
+
+60
+00:04:34,640 --> 00:04:39,480
+تبعتها مجزقة إلى عدة قطع و ذكرنا نموذج ال
+
+61
+00:04:39,480 --> 00:04:44,040
+influenza virus اللي هي مكونة من eight و في كمان
+
+62
+00:04:44,040 --> 00:04:48,850
+فيروس تانيمكوّن من .. هنشوفه كمان شوية مكوّن من
+
+63
+00:04:48,850 --> 00:04:55,490
+ten segments اللي هو الريو فيروس ten segments طبعا
+
+64
+00:04:55,490 --> 00:05:00,310
+كمان مرة ten different segments لإنه بلاش نعمل
+
+65
+00:05:00,310 --> 00:05:03,550
+mixed up مع مين؟ مع ال retro viruses ال retro
+
+66
+00:05:03,550 --> 00:05:09,430
+viruses تحتوي على جينوم in duplicate إيش يعني in
+
+67
+00:05:09,430 --> 00:05:14,680
+duplicate؟نسخة مكررة بينما العشر قطع بتاعة الريو
+
+68
+00:05:14,680 --> 00:05:20,900
+فيروس أو بتاعة ال influenza virus تمانية هدولة مش
+
+69
+00:05:20,900 --> 00:05:25,100
+مكررين هدولة كل واحدة فيهم unique مختلفة وتكون جزء
+
+70
+00:05:25,100 --> 00:05:31,360
+من ال genome تبع اللي هو ال virus طبعا كمان مجموعة
+
+71
+00:05:31,360 --> 00:05:35,710
+لازم نعرفها اللي هي اللي بتكونDouble-stranded يعني
+
+72
+00:05:35,710 --> 00:05:39,490
+فيه positive polarity فيه negative polarity
+
+73
+00:05:39,490 --> 00:05:41,770
+والتالتة جمعناها إيش مين هي اللي هي الـDouble
+
+74
+00:05:41,770 --> 00:05:46,070
+-stranded بمعنى إنه RNA مكون من positive and
+
+75
+00:05:46,070 --> 00:05:50,930
+negative polarity هذا الصورة اللي .. اللي .. اللي
+
+76
+00:05:50,930 --> 00:05:54,130
+مامناها على الصبورة بتوضح إنها الـHIV أو
+
+77
+00:05:54,130 --> 00:05:57,390
+الـRetrovirus والفكرة اللي ذكرناها قبل قليل وهو
+
+78
+00:05:57,390 --> 00:06:01,610
+إنه الوحيد في الفيروسات اللي deployed يعني مكون من
+
+79
+00:06:01,970 --> 00:06:04,930
+تو copies of the same segment اللي هو ال retro
+
+80
+00:06:04,930 --> 00:06:05,650
+virus
+
+81
+00:06:09,760 --> 00:06:12,700
+الـ Concept اللي ذكرتها قبل قليل هي Infectious
+
+82
+00:06:12,700 --> 00:06:19,060
+Nucleic Acid وهي فكرة بالمناسبة إلها مدلولات معينة
+
+83
+00:06:19,060 --> 00:06:24,200
+أهم مدلولاتها أكدت إلنا beyond reasonable doubt إن
+
+84
+00:06:24,200 --> 00:06:27,060
+المادة الوراثية هي الـ Nucleic Acid وليست
+
+85
+00:06:27,060 --> 00:06:31,920
+لبروتينات كما كان معتقد سابقا، هذه نقطة كتير مهمة
+
+86
+00:06:32,380 --> 00:06:35,680
+مرة أخرى ما هو مفهوم الـ infectious nucleic acid
+
+87
+00:06:35,680 --> 00:06:40,840
+أن المادة الوراثية للفيروس بذاتها دون ما الحاجة
+
+88
+00:06:40,840 --> 00:06:45,380
+إلى capsid أو دون ما الحاجة إلى envelope بذاتها
+
+89
+00:06:45,380 --> 00:06:50,540
+تستطيع أن تقوم بعملية replication في animal أو
+
+90
+00:06:50,540 --> 00:06:57,190
+plant أو host cell مختلفطب لاحظوا شغل معينة كنا
+
+91
+00:06:57,190 --> 00:07:01,190
+لما درسنا أول محاضرات في تركيب الفيروسات استفدنا
+
+92
+00:07:01,190 --> 00:07:06,330
+بكثرة عن البروتينات وكنا البروتينات هي المسئولة
+
+93
+00:07:06,330 --> 00:07:09,930
+الخارجية سواء كانت على ال capsid أو على ال
+
+94
+00:07:09,930 --> 00:07:15,610
+glycolipids اللي موجودة على ال envelope هي
+
+95
+00:07:15,610 --> 00:07:19,860
+المسئولة عن ال hostوالمسئولة عن ال organ
+
+96
+00:07:19,860 --> 00:07:24,460
+specificity طب أنا الأن لعندي capsid ولا عندي
+
+97
+00:07:24,460 --> 00:07:32,760
+envelope يبقى أنا تخطيت كل الحواجز اللي كان ممكن
+
+98
+00:07:32,760 --> 00:07:38,240
+تكون موجودة أمام الفيروس تخيلوا فيروس لم يكن قادرا
+
+99
+00:07:38,240 --> 00:07:43,180
+على إصابة مثلا الدجاج شيلت عنه المادة الوراثية اي
+
+100
+00:07:43,180 --> 00:07:46,740
+عفوا ال capsid تبعته واخدت بس المادة الوراثية
+
+101
+00:07:46,740 --> 00:07:50,440
+وحقنته في الدجاجإيش هيعمل؟ هيعمل infection في
+
+102
+00:07:50,440 --> 00:07:55,480
+خلايا الدواجة لكن هيكون فيروس كامل أنا أعطيت مادة
+
+103
+00:07:55,480 --> 00:07:59,900
+وراثية صح بس هو هيكون فيروس كامل وهذا الفيروس
+
+104
+00:07:59,900 --> 00:08:04,460
+الكامل لن يكون قادرا على إصابة خلايا أخرى في
+
+105
+00:08:04,460 --> 00:08:09,720
+الدواجة وصلت الصورة المهم أن أنا تحددت او تخطيت
+
+106
+00:08:09,720 --> 00:08:13,880
+حاجز ل specificity من خلال الinfectious nucleic
+
+107
+00:08:13,880 --> 00:08:17,840
+acid إذا هي نقطتين أولانية النقطة الأولى قلنا أنه
+
+108
+00:08:19,160 --> 00:08:23,540
+أثبتنا إن المادة الولاثية هي الـ DNA وليس
+
+109
+00:08:23,540 --> 00:08:28,540
+البروتينات رقم اتنين تخطينا الحاجز تبع اللي هو Can
+
+110
+00:08:28,540 --> 00:08:34,080
+bypass the host range specificity وأنا ذكرت مثال
+
+111
+00:08:34,080 --> 00:08:39,390
+إنه إذا حققنافايروس مادة ورثيلة في خلايا طبيعية
+
+112
+00:08:39,390 --> 00:08:43,050
+الفيروس بصيبهاش هيعمل infection لكن لن تكون قادرة
+
+113
+00:08:43,050 --> 00:08:46,470
+للفيروسات الناتجة على احداث infection في نفس اللي
+
+114
+00:08:46,470 --> 00:08:51,030
+هو الخلايا الجديدة طبعا مش كل الفيروسات تحتوي على
+
+115
+00:08:51,030 --> 00:08:53,810
+infectious nucleic acid مين اللي بيحتوي على
+
+116
+00:08:53,810 --> 00:08:58,290
+infectious nucleic acid؟ تلك اللتيالتي تقول إنها
+
+117
+00:08:58,290 --> 00:09:06,170
+لا تحتاج إلى إنزيمات تأخذها معاها على الخلية الـ
+
+118
+00:09:06,170 --> 00:09:10,170
+host بدا أكيد على نقطة مهمة البعض يعني ممكن برضه
+
+119
+00:09:10,170 --> 00:09:15,270
+يخطأ فيها تابوا معايا في مصطلحين بنقول virally
+
+120
+00:09:15,270 --> 00:09:19,030
+encoded و virally carried إيش يعني virally
+
+121
+00:09:19,030 --> 00:09:25,820
+encoded؟Encoded يعني موجود على ال code تبعته طريقة
+
+122
+00:09:25,820 --> 00:09:30,100
+تصنيعه موجود علميا على المادة اليوراثية لكن
+
+123
+00:09:30,100 --> 00:09:36,260
+Carried البروتين أو الانزين مصنع وجاهز ومحمول مع
+
+124
+00:09:36,260 --> 00:09:40,020
+الفيروس في فرق بين المعلومتين لما بقول Virally
+
+125
+00:09:40,020 --> 00:09:43,260
+Encoded يعني موجود على ال code تبعت الفيروس بينما
+
+126
+00:09:43,260 --> 00:09:49,590
+Carried by the virus كنا مصنع ومحمول وجاهز تمام؟زي
+
+127
+00:09:49,590 --> 00:09:54,210
+واحد بيعرف يعمل شغلة موجودة وين؟ في دماغه وعمل
+
+128
+00:09:54,210 --> 00:10:01,790
+شغلة مختلفة و لأ هذا أمرين مختلفين تماما الكلام
+
+129
+00:10:01,790 --> 00:10:05,050
+اللي ذكرته الآن معبر عنه في هذه اللوحة و اللوحة دي
+
+130
+00:10:05,050 --> 00:10:10,570
+بتقول أن هناك مجموعة من الفيروسات لا يمكن تكون لا
+
+131
+00:10:10,570 --> 00:10:13,790
+يمكن تكون ال DNA تبعها أو المادة التي تبعتها افوا
+
+132
+00:10:13,790 --> 00:10:18,140
+او ال nucleic acid تبعها infectiousوالسبب هو ما
+
+133
+00:10:18,140 --> 00:10:22,920
+ذكرته لكم أنها بذاتها غير قادرة على إنها تعمل
+
+134
+00:10:22,920 --> 00:10:26,100
+infection لأن مافيش فيها أنزمات لازم تجيب أنزماتها
+
+135
+00:10:26,100 --> 00:10:30,640
+معاها زي ال box viruses وهو ال DNA الفيروس الوحيد
+
+136
+00:10:30,640 --> 00:10:36,910
+اللي ماله اللي بتكاثر وين؟في الـ cytoplasm وبما
+
+137
+00:10:36,910 --> 00:10:40,850
+أنه بتكتب في الـ cytoplasm قلنا فلن يستطيع أن يحصل
+
+138
+00:10:40,850 --> 00:10:44,190
+على الانزيمات اللي موجودة في النواة وبالتالي عليها
+
+139
+00:10:44,190 --> 00:10:48,650
+أن يحضر انزيماته معاه وهي سبب عدم قدرته على أن
+
+140
+00:10:48,650 --> 00:10:52,330
+يكون infectious nucleic acid تلعبان الأن negative
+
+141
+00:10:52,330 --> 00:10:56,190
+stranded RNA, double stranded RNA viruses
+
+142
+00:10:56,190 --> 00:11:01,810
+وretrovirus وفي الحالات الثلاثة كلهم RNA مين
+
+143
+00:11:01,810 --> 00:11:07,060
+الحالة الرابعة للـ RNA؟الـ positive synths الـ
+
+144
+00:11:07,060 --> 00:11:10,220
+positive synth موجودة معاهم؟ مش موجودة معاهم، ليش؟
+
+145
+00:11:10,220 --> 00:11:14,800
+لأنه أصلاً مابتحترش إنزيمات من الخلايا تبعتنا،
+
+146
+00:11:14,800 --> 00:11:18,300
+تمام؟ لذلك هدولة عدم قدرتهم على إنهم يكونوا
+
+147
+00:11:18,300 --> 00:11:22,300
+infectious هو عدم قدرتهم على إنهم يعملوا
+
+148
+00:11:22,300 --> 00:11:25,600
+replication بدون ما يكون معاهم إنزيمات خاصة بيهم
+
+149
+00:11:25,600 --> 00:11:31,060
+وباقي الفيروسات الأنواع الأخرى بتكون infectious
+
+150
+00:11:31,060 --> 00:11:32,020
+nucleic acid
+
+151
+00:11:35,920 --> 00:11:39,060
+في مارض الحديث اليوم تحدثت عن اللوحة الابامنة اللي
+
+152
+00:11:39,060 --> 00:11:44,140
+بتقول انه كل الفيروسات سواء كانت DNA او RNA مقطعة
+
+153
+00:11:44,140 --> 00:11:47,180
+مش مقطعة او double stranded او single stranded
+
+154
+00:11:47,180 --> 00:11:54,440
+كلها اصلا هدفها الرئيسي تكون من messenger RNA لذلك
+
+155
+00:11:54,440 --> 00:11:59,560
+ال messenger RNAفي محور أو في الـ Center أو في قلب
+
+156
+00:11:59,560 --> 00:12:04,300
+العملية كلها سواء كان الفيروس DNA، سواء كان Single
+
+157
+00:12:04,300 --> 00:12:08,400
+Stranded DNA، سواء كان Negative RNA، سواء كان
+
+158
+00:12:08,400 --> 00:12:13,780
+Double Stranded RNA أو Postive Sense RNA، إذن كل
+
+159
+00:12:13,780 --> 00:12:21,460
+العملية متمحورة حول كيفية تكوين جنة الـ mRNA
+
+160
+00:12:26,510 --> 00:12:29,530
+التفريق بين مصطلحين carried و encoded أنا ذكرته
+
+161
+00:12:29,530 --> 00:12:32,450
+قبل قليل لكن طالعوا علي اللي أمامنا هنا هتلاقوا أن
+
+162
+00:12:32,450 --> 00:12:36,630
+في عندي polymerases DNA polymerase و RNA
+
+163
+00:12:36,630 --> 00:12:41,270
+polymerase ال DNA polymerase قد يكون من ال cell
+
+164
+00:12:41,270 --> 00:12:46,850
+كمرة encoded مش carried encoded either by the cell
+
+165
+00:12:46,850 --> 00:12:51,170
+or by the virus و كذلك الأمر بالنسبة لمين؟ ال RNA
+
+166
+00:12:51,170 --> 00:12:54,990
+قد يكون encoded by the cell or encoded by the
+
+167
+00:12:54,990 --> 00:13:00,600
+virusإيش الفرق بين Encoded و Carried؟ ك .. ك ..
+
+168
+00:13:00,600 --> 00:13:03,520
+خدنا نقول الآن كوظيفة، كتعريف ميزنهم عن بعض،
+
+169
+00:13:03,520 --> 00:13:07,600
+كوظيفة الآن Encoded معناه الحكي إنه لو صار
+
+170
+00:13:07,600 --> 00:13:10,980
+Transcription مثلا، ناخد الـBostafsins
+
+171
+00:13:10,980 --> 00:13:18,200
+..Bostafsins RNA Viruses هذه عاملة Encoding لـRNA
+
+172
+00:13:18,200 --> 00:13:23,940
+Polymerase جايب معاها RNA Polymerase ولا ..بس في
+
+173
+00:13:23,940 --> 00:13:28,640
+ال code في ال code اول ما بتدخل الخلية بيصيرها
+
+174
+00:13:28,640 --> 00:13:33,180
+translation لما بيصير ال translation ايش بيطلع ال
+
+175
+00:13:33,180 --> 00:13:36,180
+RNA .. اللي هو ال RNA polymerase RNA polymerase
+
+176
+00:13:36,180 --> 00:13:40,200
+يبقى هى محملتهوش هى حملة الشفرة تبعته فى فرق كبير
+
+177
+00:13:40,200 --> 00:13:44,460
+بين التنين كما ذكرنا المرة الماضية طبعا هذه أمثلة
+
+178
+00:13:44,460 --> 00:13:48,140
+على medically important virus انا بحب اقراها عشان
+
+179
+00:13:48,140 --> 00:13:53,060
+تصير familiar لإنه فى الدروس القادمةبتبطل لأول مرة
+
+180
+00:13:53,060 --> 00:13:57,900
+بصير مسموعة أكثر من المرة مثلا عندنا الbarvo virus
+
+181
+00:13:57,900 --> 00:14:02,360
+B19 عندنا ال human papilloma virus اللي بسبب
+
+182
+00:14:02,360 --> 00:14:07,720
+الثقاليل مشهور كتير واحد مسببات السلطان المشهورة
+
+183
+00:14:07,720 --> 00:14:14,880
+ال DNA viruses ال herpes virus زي ال herpes
+
+184
+00:14:14,880 --> 00:14:21,260
+simplex virus ال HSV هو herpes simplex virusبينما
+
+185
+00:14:21,260 --> 00:14:27,980
+ال VZV و ال CMV مار معانا قبل هيك اللي هو ال
+
+186
+00:14:27,980 --> 00:14:32,460
+cytomegalovirus و ال EPV هو ال ابستين أو ال
+
+187
+00:14:32,460 --> 00:14:37,540
+ابشتاين بار virus EPV أدينو فيروس Hepatitis B
+
+188
+00:14:37,540 --> 00:14:42,120
+virus smallpox virusبينما الـ RNA polymerase و الـ
+
+189
+00:14:42,120 --> 00:14:46,160
+cell encoded زي الـ HIV اللي هو طبعا الشهير بتاع
+
+190
+00:14:46,160 --> 00:14:52,120
+الـ HIV الـ AIDS و الـ HTLV human T lymphocyte
+
+191
+00:14:52,120 --> 00:14:58,880
+virus ال RNA polymerase اللي encoded by the virus
+
+192
+00:14:58,880 --> 00:15:02,360
+عندنا ال polyvirus و مشهور polyvirus اللي هو شلال
+
+193
+00:15:02,360 --> 00:15:06,460
+الأطفالالـ HAV و الـ HCV اللي هو Hepatitis A و
+
+194
+00:15:06,460 --> 00:15:11,040
+Hepatitis C الـ Influenza Virus الـ Measles Virus
+
+195
+00:15:11,040 --> 00:15:14,900
+ال Respiratory Syncytial Virus و كلمة Syncytial
+
+196
+00:15:14,900 --> 00:15:18,340
+انا وعدكم انه ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+197
+00:15:18,340 --> 00:15:18,420
+.. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+198
+00:15:18,420 --> 00:15:18,780
+.. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+199
+00:15:18,780 --> 00:15:18,860
+.. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+200
+00:15:18,860 --> 00:15:19,480
+.. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+201
+00:15:19,480 --> 00:15:19,740
+.. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+202
+00:15:19,740 --> 00:15:20,220
+.. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+203
+00:15:20,220 --> 00:15:21,660
+.. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا .. ا
+
+204
+00:15:21,660 --> 00:15:30,200
+.. ا .. ا .. ا .. ا .. ا
+
+205
+00:15:30,200 --> 00:15:37,450
+.. اوسمى كذلك من الـ cytopathic effect تبعه ال
+
+206
+00:15:37,450 --> 00:15:42,130
+rabies اللي هو ده الكلب الربلة ال german مثل
+
+207
+00:15:42,130 --> 00:15:46,450
+الحصبة الألمانية و ال rota اعتقد انتوا بنات طعمته
+
+208
+00:15:46,450 --> 00:15:50,970
+في الأددية تطعيم اللي هو ال .. ال .. الربلة virus
+
+209
+00:15:50,970 --> 00:15:55,940
+عارفين ليش طعمته؟لأن في سن الزواج عنا مبكر قد يبدأ
+
+210
+00:15:55,940 --> 00:15:59,180
+من وين؟ من الإعدادية وهذه من الفيروسات من
+
+211
+00:15:59,180 --> 00:16:04,060
+الفيروسات اللي لو أصيبت فيها الأم الحامل قد يصاب
+
+212
+00:16:04,060 --> 00:16:08,440
+الطفل يجهض أو يعني يولد ميتا يعني يصير له تشوهات
+
+213
+00:16:08,440 --> 00:16:12,560
+أو أمراض فبيصير تطهيم للفتيات قبل سن الزواج بهذا
+
+214
+00:16:12,560 --> 00:16:15,000
+ال .. ال .. ال virus بتتذكر ان كنت طعمت في هذه
+
+215
+00:16:15,000 --> 00:16:20,110
+الليلة ولا متذكروش؟الـ Rotavirus اللي حكينا عنه
+
+216
+00:16:20,110 --> 00:16:23,730
+مرارا و تكرارا أنه المسبب الرئيسي لأمراض الإسهال
+
+217
+00:16:23,730 --> 00:16:28,630
+في العالم Ebola المرض الخطير جدا Ebola virus ال
+
+218
+00:16:28,630 --> 00:16:32,230
+Arena virus اللي هو كان الوحيد في تركيبه بيحتوي
+
+219
+00:16:32,230 --> 00:16:34,690
+على Ribosome اللي يقولون عنها non-functional
+
+220
+00:16:34,690 --> 00:16:39,070
+ribosome والهانتافيروس برضه من الفيروسات اللي
+
+221
+00:16:39,070 --> 00:16:41,790
+لاتقل خطورة عن ال Ebola virus
+
+222
+00:16:46,220 --> 00:16:51,300
+في ظاهرة حلوة جميلة برضه في الـ Virology وهي أن
+
+223
+00:16:51,300 --> 00:16:57,500
+بعض الفيروسات لا تقوم بترجمة البروتين بشكل منفصل
+
+224
+00:16:57,500 --> 00:17:02,580
+عن البروتينات الأخرى وإنما تقوم بقراءة كل ال mRNA
+
+225
+00:17:02,580 --> 00:17:10,540
+كاملا كجينوم كامل فبيطلع عنده بروتين واحد non
+
+226
+00:17:10,540 --> 00:17:14,540
+-functional ايش يعني non-functional؟ مالوش وظيفة
+
+227
+00:17:15,200 --> 00:17:19,580
+بمعنى أنا ب .. بديب مثال بقول لو أردنا صنع طاولة
+
+228
+00:17:19,580 --> 00:17:24,400
+نحضر قطعة من الخشب قطعة الخشب و هي قطعة خشب هكذا
+
+229
+00:17:24,400 --> 00:17:29,180
+ليست طاولة ولا يمكن أن نقول هذه وظيفتها سطح و هذه
+
+230
+00:17:29,180 --> 00:17:34,460
+وظيفتها قوام و هذه وظيفتها درج إلا بعد ما نقطعهم و
+
+231
+00:17:34,460 --> 00:17:41,540
+ان القطع بتصير تركب و تجوم بوظيفة محددة وظيفة سطح
+
+232
+00:17:41,540 --> 00:17:47,090
+و وظيفة درج و الاخريالـ precursor polypeptide اللي
+
+233
+00:17:47,090 --> 00:17:52,770
+هو الـ protein الطوير هذا non-functional بيجي ال
+
+234
+00:17:52,770 --> 00:17:56,990
+.. الانزيم اللي اسمه protease بيجطه في أماكن
+
+235
+00:17:56,990 --> 00:18:01,570
+مختلفة لما يجطع القطع تبعته هذي بيصير functional
+
+236
+00:18:01,570 --> 00:18:05,950
+أو structural ايش انه structural؟ اما بنائية او
+
+237
+00:18:05,950 --> 00:18:09,970
+وظيفية اما انزيمات او انها قطع مثلا بتكون الهيكل
+
+238
+00:18:09,970 --> 00:18:15,280
+الخارجي للفيروسكمان مراجع اسمها precursor
+
+239
+00:18:15,280 --> 00:18:20,940
+polypeptide مش كل الفيروسات تمتلك هذه الصفة إنها
+
+240
+00:18:20,940 --> 00:18:24,860
+تعمل precursor polypeptide في كمان حاجة جميلة بنات
+
+241
+00:18:24,860 --> 00:18:32,320
+في الفيروسات ذكية جدا إذا أنا عندي هاتف صغير زي
+
+242
+00:18:32,320 --> 00:18:39,400
+هذا تمام الهاتف هذا هو الوحيد اللي بأملكه أنا فأنا
+
+243
+00:18:39,400 --> 00:18:45,040
+صرت أستخدمه كساعةتمام؟ بإن أنا أفتح و أطلع على جزء
+
+244
+00:18:45,040 --> 00:18:49,260
+معين من الجوال ممكن انا أحضر منه ال presentation
+
+245
+00:18:49,260 --> 00:18:52,520
+ال PowerPoint اعرض عليه ال PowerPoint فصرت انا
+
+246
+00:18:52,520 --> 00:18:55,420
+اوضف و انا ماعنديش غيره ماعنديش أشياء أخرى غيره
+
+247
+00:18:55,420 --> 00:18:59,000
+فاضطرت انا بهذا الحجم و بهذه الإمكانيات ان انا
+
+248
+00:18:59,000 --> 00:19:04,380
+استغل الجوال لأكتر من ايه من شغل معين فتخيلوا ان
+
+249
+00:19:04,380 --> 00:19:12,890
+ذكاء الفيروس انه عاملهي mRNA تمام ال mRNA كل ثلاث
+
+250
+00:19:12,890 --> 00:19:19,530
+قواعد بيقراهم amino acid تمام لو
+
+251
+00:19:19,530 --> 00:19:23,790
+بدأنا من ال zero من رقم واحد و قرأنا هيطلع معايا
+
+252
+00:19:23,790 --> 00:19:27,030
+protein
+
+253
+00:19:27,030 --> 00:19:32,370
+لاندرهان مثلا تمام طيب لو قفزنا عن أول واحدة أو
+
+254
+00:19:32,370 --> 00:19:36,960
+التانية و بدأنا القراة من التالتةهل البروتين اللي
+
+255
+00:19:36,960 --> 00:19:40,900
+هيطلع هو نفس البروتين الأولاني؟ أكيد لا لإن ال
+
+256
+00:19:40,900 --> 00:19:45,200
+code كلها اختلفت، مدان بدأت أنا أو قفزت أو سبت أو
+
+257
+00:19:45,200 --> 00:19:49,120
+حدفت هذا زي mutation و لا، يبقى كل إشي هيتغير
+
+258
+00:19:49,120 --> 00:19:53,090
+بعدينفبروح بيقرأ من أماكن مختلفة، different
+
+259
+00:19:53,090 --> 00:19:58,830
+reading starting points، نقاط قراءة مختلفة وبيبدأ
+
+260
+00:19:58,830 --> 00:20:02,870
+يطلع لنا proteinات، هو ما استخدم mRNA جديد، هو
+
+261
+00:20:02,870 --> 00:20:06,970
+استخدم نفس ال mRNA، لكن بدأ يقرأ من إيه، من ..
+
+262
+00:20:06,970 --> 00:20:11,830
+فبيطلع كمية كبيرة من ال proteinات، من مادة وراثية
+
+263
+00:20:11,830 --> 00:20:16,610
+صغيرةهذه هي الفيروسات اللي هي احنا قاعدين نجومها
+
+264
+00:20:16,610 --> 00:20:20,430
+كائنات غير حية ولا تمتلك من الحياة الا القدرة على
+
+265
+00:20:20,430 --> 00:20:28,290
+التكاثر لكن لديها الحقيقة قدرات هائلة من اشهر
+
+266
+00:20:28,290 --> 00:20:34,750
+الفيروسات اللي بتكون precursor polypeptideالفيروس
+
+267
+00:20:34,750 --> 00:20:39,970
+اللي هو ال بيكورنا فيروس و كلمة بيكورنا جاية من
+
+268
+00:20:39,970 --> 00:20:45,930
+تلت كلمات فيروس و Pico معناها very small و RNA
+
+269
+00:20:45,930 --> 00:20:51,810
+يعني very small RNA viruses اللي هي مثل ال polio
+
+270
+00:20:51,810 --> 00:20:57,320
+فيروس تبع الشيء للأطفال ال Rhinoالرشحة في أول
+
+271
+00:20:57,320 --> 00:21:01,380
+محاضرة من المحاضرات وردتكوا صورة لحجوم الفيروسات
+
+272
+00:21:01,380 --> 00:21:05,340
+ووردتكوا أن الراينو فيروس بالفعل صغير جدا and
+
+273
+00:21:05,340 --> 00:21:09,620
+hepatitis A virus in which the genome RNA acting
+
+274
+00:21:09,620 --> 00:21:15,080
+as a mRNA is translated into a single polypeptide
+
+275
+00:21:15,080 --> 00:21:20,760
+أيش سميناها كده مرة precursor polypeptideوهو تخيل
+
+276
+00:21:20,760 --> 00:21:25,200
+انه
+
+277
+00:21:25,200 --> 00:21:31,460
+واحد ماسك مجصه وقاعد بجزجز في حاله عندي precursor
+
+278
+00:21:31,460 --> 00:21:37,420
+polypeptide جزء منه جزء منه هو مين ال protease ال
+
+279
+00:21:37,420 --> 00:21:41,540
+protease جاعد بيقطع في باقي اللي هو ال precursor
+
+280
+00:21:41,540 --> 00:21:47,120
+عشان يطلع منهم functional proteins كما ذكرناوبنى
+
+281
+00:21:47,120 --> 00:21:55,200
+هذا كمثال مثال من بيبتايد يعمل على نفسه
+
+282
+00:21:55,200 --> 00:21:59,940
+بجزجز في حاله كمان
+
+283
+00:21:59,940 --> 00:22:03,840
+شغل مهم جدا او كمان مجموعة من الفيروسات عندها
+
+284
+00:22:03,840 --> 00:22:07,720
+القدرة على إنتاج ال precursor polypeptide فيروس ال
+
+285
+00:22:07,720 --> 00:22:12,660
+aidsالـ AIDS اللي هم الـ Retroviruses عارفين إيش
+
+286
+00:22:12,660 --> 00:22:16,680
+معنات Retro؟ Retro معناها إيه ده الخلف؟ إيه ده
+
+287
+00:22:16,680 --> 00:22:21,760
+الخلف؟ وسميتها كذا لإن أحنا أصلا متعودين نمشي DNA،
+
+288
+00:22:21,760 --> 00:22:25,740
+RNA، Protein بس هذا عبارة عن RNA ورجعنا برجوها
+
+289
+00:22:25,740 --> 00:22:32,160
+لمين؟ لل DNA فسموها Retroviruses الآن الكلام اللي
+
+290
+00:22:32,160 --> 00:22:35,080
+هحكيه إيه له معنى وإيه له مغزة وإيه له مدلولات
+
+291
+00:22:35,080 --> 00:22:39,320
+مهمة بيننا نستوعبهافيه انا two genes مشهورين في
+
+292
+00:22:39,320 --> 00:22:43,560
+الـHIV اسمهم Pol and Pol and Gag او Gag and Pol
+
+293
+00:22:43,560 --> 00:22:48,560
+genes موجودين في الـHIV الان بيطلعوا بو بريكارسور
+
+294
+00:22:48,560 --> 00:22:52,340
+بوليبيبتايد بمعنى اخر بترجمه مع بعض بترجمه مع بعض
+
+295
+00:22:52,340 --> 00:22:58,420
+مين اللي لازم يجطعه عشان يصير functional الان
+
+296
+00:22:58,420 --> 00:23:04,340
+هذا البروتياز هو الهدف لمجموعة كبيرة من العقاقير
+
+297
+00:23:04,590 --> 00:23:10,130
+اللي بتستخدم لعلاج مرض ال AIDS إذا ما فهمنا العميق
+
+298
+00:23:10,130 --> 00:23:16,570
+لكيفية ال replication لأي virus تمام هي المنطلق
+
+299
+00:23:16,570 --> 00:23:21,130
+تبعنا لإيجاد استراتيجيات محددة لمكافحة هذا ال
+
+300
+00:23:21,130 --> 00:23:26,750
+virus ففهمنا هنا أن ال polypeptide هذا إذا ما
+
+301
+00:23:26,750 --> 00:23:31,990
+تكسرش تمام ال HIV مش هيكمل الدولة تبعتهفمين اللي
+
+302
+00:23:31,990 --> 00:23:37,010
+بيكسروا ال بروتيايز فاسمها بروتيايز inhibitors
+
+303
+00:23:37,010 --> 00:23:39,730
+مجموعة من العقاقية اسمها بروتيايز inhibitors
+
+304
+00:23:39,730 --> 00:23:45,310
+وبتستخدم في علاج طبعا يعني ليست كافية لدرجة انه
+
+305
+00:23:45,310 --> 00:23:48,730
+يصير في شفاء لكن بتبطء من عملية اللي هو ال
+
+306
+00:23:48,730 --> 00:23:53,930
+replication لل virus الفلافي viruses الفلافي
+
+307
+00:23:53,930 --> 00:23:59,050
+معناها أصفر فلافي معناها أصفرفلوفي فيروس مثلًا
+
+308
+00:23:59,050 --> 00:24:05,230
+Hepatitis C و Yellow Fever و الهيباطيتس برضه فيها
+
+309
+00:24:05,230 --> 00:24:09,250
+يلو ولا لأ لأن الإنسان لإنه بيستخدمه كبد بيستخدمه
+
+310
+00:24:09,250 --> 00:24:12,830
+بيلوروبين عالي تمام فبصير فيه لونه لونه أصفر
+
+311
+00:24:12,830 --> 00:24:18,590
+Yellow Virus برضه بتشتغل على أو بتطلع precursor
+
+312
+00:24:18,590 --> 00:24:22,050
+polypeptide that must be cleaved to form
+
+313
+00:24:22,050 --> 00:24:27,000
+functional proteinsعلى النقيد other viruses such
+
+314
+00:24:27,000 --> 00:24:31,360
+as influenza virus and rotavirus have segmented
+
+315
+00:24:31,360 --> 00:24:38,740
+genome هل هناك داعي أن تجهز تصنع precursor protein
+
+316
+00:24:38,740 --> 00:24:44,820
+لأن الجينم تبقى أصله مقطع فكل واحد يقرأ على حده
+
+317
+00:24:44,820 --> 00:24:51,120
+ويطلع مجموعة صغيرة من البروتيناتوكل جزء منه ينقل
+
+318
+00:24:51,120 --> 00:24:56,680
+إلى بيبتايد مفروض من بيكورنا بيكورنا بيكورنا
+
+319
+00:24:56,680 --> 00:24:58,460
+بيكورنا بيكورنا بيكورنا بيكورنا بيكورنا بيكورنا
+
+320
+00:24:58,460 --> 00:25:11,800
+بيكورنا بيكورنا بيكورنا بيكورنا بيكورنا بيكورنا
+
+321
+00:25:12,690 --> 00:25:16,110
+الـ Viral Genome is the mRNA اللي هو الـ Postive
+
+322
+00:25:16,110 --> 00:25:20,570
+Sense mRNA بصير له Translation Full Length على طول
+
+323
+00:25:20,570 --> 00:25:25,610
+مين؟ على طول الـ mRNA طالع عندي Polypeptide لأن
+
+324
+00:25:25,610 --> 00:25:29,490
+الـ Polypeptide is cleaved by اللي هو فيروس انكودت
+
+325
+00:25:29,490 --> 00:25:32,650
+و انها Proteases إلى Protein 1، Protein 2، Protein
+
+326
+00:25:32,650 --> 00:25:36,570
+3، إلى آخر الـ Retrovirus نفس الشيء الـ Gag و الـ
+
+327
+00:25:36,570 --> 00:25:39,870
+Pol اللي احنا حكينا عنهم قبل قليل، إذن بنقدر نقول
+
+328
+00:25:39,870 --> 00:25:45,220
+إنه فيه استراتيجياتلأ تصنيع البروتين في الفيروسات
+
+329
+00:25:45,220 --> 00:25:50,040
+غير عن تلك التي يمتلكها الإنسان أو المخلوقات
+
+330
+00:25:50,040 --> 00:25:54,120
+الأخرى من ضمنها اللي هي الـ precursor protein و ال
+
+331
+00:25:54,120 --> 00:25:56,640
+different reading frames اللي احنا ذكرنا عنهم قبل
+
+332
+00:25:56,640 --> 00:26:03,220
+قليل نطلعها جدول كتير مهم و أهمية هذا الجدول تمبع
+
+333
+00:26:03,220 --> 00:26:07,700
+في وين فانا بتكلم على virus encoded proteases of
+
+334
+00:26:07,700 --> 00:26:11,460
+medically important virusesاللي احنا بشكل عام
+
+335
+00:26:11,460 --> 00:26:14,480
+بيقولنا ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+336
+00:26:14,480 --> 00:26:14,680
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+337
+00:26:14,680 --> 00:26:15,360
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+338
+00:26:15,360 --> 00:26:16,540
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+339
+00:26:16,540 --> 00:26:21,400
+ال ال ال ال
+
+340
+00:26:21,400 --> 00:26:21,640
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+341
+00:26:21,640 --> 00:26:25,840
+ال ال
+
+342
+00:26:25,840 --> 00:26:27,320
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+343
+00:26:27,320 --> 00:26:27,320
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+344
+00:26:27,320 --> 00:26:27,320
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+345
+00:26:27,320 --> 00:26:27,340
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+346
+00:26:27,340 --> 00:26:27,340
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+347
+00:26:27,340 --> 00:26:27,340
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+348
+00:26:27,340 --> 00:26:27,340
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+349
+00:26:27,340 --> 00:26:27,380
+ال ال ال
+
+350
+00:26:34,230 --> 00:26:39,750
+ب كورنا فيروس فلافي فيروس توغا فيروس كورونا فيروس
+
+351
+00:26:39,750 --> 00:26:44,490
+ريترو فيروس ايش معنى ما دولة كلهم لديهم
+
+352
+00:26:44,490 --> 00:26:49,210
+polypeptide nature single polypeptide formed by
+
+353
+00:26:49,210 --> 00:26:53,650
+translation of entire genome RNA هذا ال poly
+
+354
+00:26:53,650 --> 00:26:57,390
+protein عفوا اللي هو ال precursor polypeptide poly
+
+355
+00:26:57,390 --> 00:27:00,790
+protein نفس المعنى تمام precursor polypeptide
+
+356
+00:27:01,080 --> 00:27:05,900
+Single polypeptide الفلافي single polypeptide more
+
+357
+00:27:05,900 --> 00:27:09,980
+than one polypeptide formed by translation of
+
+358
+00:27:09,980 --> 00:27:14,480
+subgenomic mRNA subgenomic يعني بيكونش بيصنع one
+
+359
+00:27:14,480 --> 00:27:20,680
+single mRNA أكتر من mRNA يبقى هنا one one هنا أكتر
+
+360
+00:27:20,680 --> 00:27:24,920
+من واحد الكورونا فيروس more than one نفس الشي
+
+361
+00:27:24,920 --> 00:27:30,490
+ريترو فيروس more than one polypeptideالـPol
+
+362
+00:27:30,490 --> 00:27:36,010
+والـGag أكيد فيه other proteins site of
+
+363
+00:27:36,010 --> 00:27:40,810
+proteolytic cleavage طلعوا كلهم في الـcytoplasm
+
+364
+00:27:40,810 --> 00:27:45,150
+كلهم في الـcytoplasm ما هذا اللي هو الأخير
+
+365
+00:27:45,150 --> 00:27:51,410
+الـretrovirus وين بتتم العملية؟ لما الفيروس بده
+
+366
+00:27:51,410 --> 00:27:56,570
+يطلع يكون .. بيكون جاهز ويطلع تمام؟ بتروح ..
+
+367
+00:27:56,570 --> 00:28:00,530
+بتشتغل في .. في المنطقة هذهقبل ذلك يعني هو في
+
+368
+00:28:00,530 --> 00:28:04,010
+الآخر الـ budding virion من وين بيعمل budding؟ هو
+
+369
+00:28:04,010 --> 00:28:06,690
+بيطلع من الـ cytoplasm مظبوط اللي بيطلع من ال cell
+
+370
+00:28:06,690 --> 00:28:09,270
+membrane وبالتالي نقدر نعتبرها مجازا انها برضه من
+
+371
+00:28:09,270 --> 00:28:14,430
+وين من ال cell membrane طبعا الأمثلة على كل واحدة
+
+372
+00:28:14,430 --> 00:28:18,150
+منهم على كل مجموعة من هذه المجموعة صرنا ذاكرينهم
+
+373
+00:28:18,150 --> 00:28:24,500
+بشكل متكررفحبّدا إنه برضه نخلي هذه الأسماء
+
+374
+00:28:24,500 --> 00:28:32,460
+familiar لدينا لإنه هحتاجها في المستقبل كثيرا ال
+
+375
+00:28:32,460 --> 00:28:36,120
+complementarity هي الفكرة الأساسية اللي أنا ذكرتها
+
+376
+00:28:36,120 --> 00:28:41,580
+قبل قليل لما قلت إنه كل negative بده positive و ال
+
+377
+00:28:41,580 --> 00:28:44,260
+positive بده negative ال single strand بده يصير
+
+378
+00:28:44,260 --> 00:28:48,680
+positive الأن تعالوا تطلعوا على حاجة لذيذة في
+
+379
+00:28:48,680 --> 00:28:49,320
+الفيروسات
+
+380
+00:28:51,980 --> 00:28:58,120
+single-stranded RNA هو مين؟ هو الـ genome تبعنا
+
+381
+00:28:58,120 --> 00:29:02,980
+وانا افترض انه postive strand والـ postive strand
+
+382
+00:29:02,980 --> 00:29:08,980
+مش قلنا عنه جاب شوية احنا قلنا عنه انه هو ايه
+
+383
+00:29:08,980 --> 00:29:14,860
+عمارناه و بكثرة لكن يا اهل ترى الفيروس غبي لدرجة
+
+384
+00:29:14,860 --> 00:29:20,370
+انه يغامر بانه نستخدمالمادة الوراثية الأساسية
+
+385
+00:29:20,370 --> 00:29:27,730
+تبعته كقالب بيعمل copy كمplementary كمان بتصف معنى
+
+386
+00:29:27,730 --> 00:29:32,670
+بتعمل complementary copy هاي ال genome تمام؟ ال
+
+387
+00:29:32,670 --> 00:29:39,130
+complementary copy بيصير قالب بتصنع لمين؟ الجينوم
+
+388
+00:29:39,130 --> 00:29:44,190
+تبعها الجينوم تبعها الآن في نسخ منه they can act
+
+389
+00:29:44,190 --> 00:29:48,990
+as a mononymيبقى حتى الـ positive sense عمل
+
+390
+00:29:48,990 --> 00:29:52,070
+negative sense عشان الـ negative sense إيش ماله؟
+
+391
+00:29:52,070 --> 00:29:55,570
+to act as a template طب لو كان الفيروس negative
+
+392
+00:29:55,570 --> 00:30:01,730
+sense برضه هيشتغل بنفس الطريقة، هيكون positive ..
+
+393
+00:30:01,730 --> 00:30:05,670
+complementary positive sense عشان هذا التاني to
+
+394
+00:30:05,670 --> 00:30:09,030
+act as a template and unimportant في نفس اللي هو
+
+395
+00:30:09,030 --> 00:30:13,340
+.. في نفس الوقت، إذا الـ complementarityمفهومه أن
+
+396
+00:30:13,340 --> 00:30:16,440
+إذا كان هناك single-stranded يتحول لمين؟ لـDouble
+
+397
+00:30:16,440 --> 00:30:19,660
+-stranded وإذا كان Double-stranded أيضًا لما
+
+398
+00:30:19,660 --> 00:30:23,000
+بينقسم، بده يتقسم واحد positive-strand وواحد
+
+399
+00:30:23,000 --> 00:30:25,560
+negative-strand، بده يصير له برضه complementation
+
+400
+00:30:25,560 --> 00:30:27,840
+في الفيروس
+
+401
+00:30:30,260 --> 00:30:33,960
+أعتقد إن هذا اللوحة برضه كافية نفهمنا إن ال
+
+402
+00:30:33,960 --> 00:30:37,280
+polyvirus هو single-stranded بُسط في single
+
+403
+00:30:37,280 --> 00:30:40,200
+-stranded ال intermediate form إيش هي ال
+
+404
+00:30:40,200 --> 00:30:43,060
+intermediate form؟ اللي هو ال complementary إليه
+
+405
+00:30:43,060 --> 00:30:47,460
+هيكون إيه؟ negative senseالجينوم الأخير اللي هياخد
+
+406
+00:30:47,460 --> 00:30:52,480
+معاه الفيروس اللي هو مين دائما العمود هذا هو نفس
+
+407
+00:30:52,480 --> 00:30:56,120
+العمود هذا طالع عليهم double-stranded double
+
+408
+00:30:56,120 --> 00:30:59,720
+-stranded double-stranded double-stranded single
+
+409
+00:30:59,720 --> 00:31:04,660
+-stranded DNA لأنه مش معقول يدخل بجينوم و يطلع
+
+410
+00:31:04,660 --> 00:31:08,700
+بجينوم أخر و لازم يطلع نفس المين نفس النسخ بينما
+
+411
+00:31:08,700 --> 00:31:11,540
+اللي بيختلف مين اللي هو ال intermediate form و
+
+412
+00:31:11,540 --> 00:31:14,200
+غالبا انتوا صرتوا عارفين single-stranded وصير له
+
+413
+00:31:14,200 --> 00:31:18,080
+positiveطيب المرحلة الأخيرة تقريبا في عملية اللي
+
+414
+00:31:18,080 --> 00:31:20,860
+هو الـ replication اللي هي مرحلة ال assembly and
+
+415
+00:31:20,860 --> 00:31:24,900
+release كلمة assembly معناها اللي هو تجميع لل
+
+416
+00:31:24,900 --> 00:31:28,280
+virus the progeny particles are assembled by
+
+417
+00:31:28,280 --> 00:31:33,280
+packaging يعني في نقطتين الآن مهمين عنها المادة
+
+418
+00:31:33,280 --> 00:31:38,040
+الوراثية و ال capsid و كلاهما قد تكون كلاهما قد
+
+419
+00:31:38,040 --> 00:31:43,080
+تكون المرحلة المنطقية أنه نعمل عملية تجميع للمادة
+
+420
+00:31:43,080 --> 00:31:47,770
+الوراثية داخل اللي هوالـ Capsule Little is known
+
+421
+00:31:47,770 --> 00:31:50,990
+about the precise steps in the assembly process
+
+422
+00:31:50,990 --> 00:31:56,290
+معلوماتنا يعني ضعيفة جدا ما الذي يحدث خلال هذه
+
+423
+00:31:56,290 --> 00:31:59,870
+العملية وعشان اقولكوا ان معلوماتنا ضعيفة مش جادرين
+
+424
+00:31:59,870 --> 00:32:04,570
+نفسر لماذا يخطئ الفيروسات او تخطئ الفيروسات وتقوم
+
+425
+00:32:04,570 --> 00:32:10,190
+بتعبئة مادة وراثية مثلا من الhost لو فاهمين كان
+
+426
+00:32:10,190 --> 00:32:13,570
+جادرنا نفسر مش جادرين نفهم العملية بشكل جيد
+
+427
+00:32:14,180 --> 00:32:18,160
+surprisingly certain viruses can be assembled in
+
+428
+00:32:18,160 --> 00:32:21,340
+the test tube by using only purified RNA and
+
+429
+00:32:21,340 --> 00:32:22,400
+purified proteins
+
+430
+00:32:25,480 --> 00:32:29,980
+فيروسات من خلال فقط وضع الـ protein اللي هو الـ
+
+431
+00:32:29,980 --> 00:32:34,860
+capsular زاد المادة الوراثية هذا ك assembly فواضح
+
+432
+00:32:34,860 --> 00:32:38,900
+ان ال assembly خلّيني نقول في جزء منه self
+
+433
+00:32:38,900 --> 00:32:44,540
+-assembly بمعنى انه مش حاجة خلّيني نقول انه بتتطلب
+
+434
+00:32:44,540 --> 00:32:48,200
+خطوات معينة لأ حاجة معروفة مدى ما اتكونت ال
+
+435
+00:32:48,200 --> 00:32:52,080
+capsular و اتكونت المادة الوراثية بيصير عملية self
+
+436
+00:32:52,080 --> 00:32:53,640
+-assembly لها و بتمشي
+
+437
+00:32:58,490 --> 00:33:03,610
+الان ال release لل virus particle قد يكون من خلال
+
+438
+00:33:03,610 --> 00:33:10,610
+rapture وكلمة rapture يعني انفجار وهذا سمة من سمات
+
+439
+00:33:10,610 --> 00:33:17,190
+الفيروسات اللي مالهاش envelope بتعمل license ل ال
+
+440
+00:33:17,190 --> 00:33:23,330
+cell membrane و بتخرج غالبا دفعة واحدة وهذا اللذي
+
+441
+00:33:23,330 --> 00:33:27,940
+نقوله نحن عندما نتحدث عن ال cytopathic effectماذا
+
+442
+00:33:27,940 --> 00:33:32,680
+يعني انتشار توبيتك افكت يعني يعني درر حدث في
+
+443
+00:33:32,680 --> 00:33:37,110
+الخلايا نتيجة نمومين الفيروسغالبا تلك الفيروسات
+
+444
+00:33:37,110 --> 00:33:41,110
+ستحدث لنا هذا الضرر و انا كمان مرة اعتذر عن ادم
+
+445
+00:33:41,110 --> 00:33:45,070
+قدرته على تشغيل ال animation حتى ممكن بعد اللي كان
+
+446
+00:33:45,070 --> 00:33:51,850
+لنا وقت بعد المحاضرة نطلع على طريقة الخروج تبع
+
+447
+00:33:51,850 --> 00:33:57,310
+الفيروسات خاصة ال envelope هذا للميه نقول انها لل
+
+448
+00:33:57,310 --> 00:34:02,690
+non envelopeبتطلع و بتاخد معاها جزء من الـ cell
+
+449
+00:34:02,690 --> 00:34:06,970
+membrane و الـ cell membrane بتسكر فبالتالي هو
+
+450
+00:34:06,970 --> 00:34:12,450
+كأنه شيئا لا يحدث أصلا داخل الخلية و لا يمكن
+
+451
+00:34:12,450 --> 00:34:16,050
+التعرف على أن الخلية أصلا مصابة إلا من خلال الـ
+
+452
+00:34:16,050 --> 00:34:19,590
+glycoproteins اللي موجودة على ال surface تبع من ال
+
+453
+00:34:19,590 --> 00:34:23,190
+glycoproteins صنعها دي اللي هو ال virus itself
+
+454
+00:34:25,260 --> 00:34:27,940
+طبعاً كلهم بياخدوا من ال cell membrane ما عادة
+
+455
+00:34:27,940 --> 00:34:30,900
+قلنا اللي هو ال herpes virus بياخده من منين؟ من ال
+
+456
+00:34:30,900 --> 00:34:35,960
+nuclear membrane الحاجة اللي ال body .. ال bodying
+
+457
+00:34:35,960 --> 00:34:39,240
+بقى بيغير في طبيعته اللي هو ال virus وهي .. هاي
+
+458
+00:34:39,240 --> 00:34:44,500
+صورة بتوضح لنا أنههي الفيروس بدأت تشكل و تجمع و
+
+459
+00:34:44,500 --> 00:34:49,380
+ماتوريشن و بعدين الجليكو بروتين و أخد انفلوب ماء و
+
+460
+00:34:49,380 --> 00:34:53,600
+خرج إلى الخارج و الخلية بقيت intact كما هي لم
+
+461
+00:34:53,600 --> 00:34:59,760
+تتأثر بتكاثر الفيروس طبعا
+
+462
+00:34:59,760 --> 00:35:03,780
+الفيروس الإماراني الصحي بده يعني ممكن محاضرة لحاله
+
+463
+00:35:03,780 --> 00:35:08,180
+لأنه في معلومات كثيرة فنفقيها ان شاء الله للمرة
+
+464
+00:35:08,180 --> 00:35:08,980
+القادمة
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/sduOU8FVa0c.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/sduOU8FVa0c.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0396adc387e10c598165ff54600231e7c66af12c
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/sduOU8FVa0c.srt
@@ -0,0 +1,2019 @@
+1
+00:00:21,140 --> 00:00:24,620
+بسم الله الرحمن الرحيم نكمل إن شاء الله ما بدأنا 
+
+2
+00:00:24,620 --> 00:00:28,940
+المحاضرات السابقة في الـ RNA envelope viruses كنا 
+
+3
+00:00:28,940 --> 00:00:32,480
+قد وصلنا إلى الـ mumps virus وشرحنا لجزء كبير منه
+
+4
+00:00:32,480 --> 00:00:37,300
+لذلك إنه نعمل quick revision لـ الـ mumps virus كنا
+
+5
+00:00:37,300 --> 00:00:41,000
+هو typically باراميكسوفيروس من ناحية المادة
+
+6
+00:00:41,000 --> 00:00:44,760
+الوراثية ومن ناحية حتى كمان الـ .. الـ .. الـ
+
+7
+00:00:44,760 --> 00:00:49,090
+symmetry بتاعة الكبسيد ووجود الـ envelope خلينا
+
+8
+00:00:49,090 --> 00:00:53,770
+عن أنه بيحتوي على two spikes واحد منهم بيحتوي على 
+
+9
+00:00:53,770 --> 00:00:57,570
+كل من الـ Neuraminidase و الـ Hemagglutinin
+
+10
+00:00:57,570 --> 00:01:00,230
+والثاني بيحتوي على الـ fusion protein مع
+
+11
+00:01:00,230 --> 00:01:04,170
+الهيموليسين يعني عندنا أربع خصائص في هذا الـ virus
+
+12
+00:01:04,170 --> 00:01:07,310
+بالإضافة إلى soluble antigen هذا الـ soluble
+
+13
+00:01:07,310 --> 00:01:10,570
+antigen تم توظيفه أو استخدامه في عملية الـ
+
+14
+00:01:10,570 --> 00:01:12,550
+diagnosis لهذا الـ virus
+
+15
+00:01:15,380 --> 00:01:18,520
+واتفقنا إنه بينتقل عبر الـ respiratory droplets وإن
+
+16
+00:01:18,520 --> 00:01:22,640
+نسبة كبيرة قد تصل إلى 30% من الأطفال المصابين لا
+
+17
+00:01:22,640 --> 00:01:26,240
+يظهر عليهم معناه سميناها subclinical or inapparent
+
+18
+00:01:26,240 --> 00:01:30,160
+infection ويعادل حالة انخفاض انخفاض كبير جدا في
+
+19
+00:01:30,160 --> 00:01:32,920
+الولايات المتحدة وفِي معظم الدول الأخرى التي 
+
+20
+00:01:32,920 --> 00:01:38,750
+تتعامل مع الـ vaccination بجدية كان فيه رقم لا لا
+
+21
+00:01:38,750 --> 00:01:42,470
+يزيد عن الـ الـ الـ ألف يعني ستمائة وثلاثة و
+
+22
+00:01:42,470 --> 00:01:45,470
+ثمانين حالة سنة ألف وتسعمائة وسبعة وتسعين
+
+23
+00:01:45,470 --> 00:01:48,810
+وبالتأكيد في السنوات اللاحقة قل هذا الرقم
+
+24
+00:01:51,070 --> 00:01:54,550
+اتكلمنا أيضًا إنه الإصابة به سواء كان unilateral
+
+25
+00:01:54,550 --> 00:01:58,690
+أو bilateral بالـ .. بالـ مصفر بتوفر long life،
+
+26
+00:01:58,690 --> 00:02:01,710
+immunity وبتالي كان هذا سر نجاح اللي وضعنا الـ
+
+27
+00:02:01,710 --> 00:02:05,410
+vaccination اللي استخدمنا أو وظفنا لمنع هذا المرض
+
+28
+00:02:06,980 --> 00:02:09,320
+اتكلمنا عن بعض الـ complications من ضمن الـ
+
+29
+00:02:09,320 --> 00:02:12,360
+complications كنا فيه حاجتين اسمها Orchitis اللي
+
+30
+00:02:12,360 --> 00:02:15,560
+هي التهاب الخصية وحاجة اسمها meningitis و
+
+31
+00:02:15,560 --> 00:02:19,940
+تعلمنا أن الـ الـ mumps virus هو واحد من ثلاثة
+
+32
+00:02:19,940 --> 00:02:23,380
+مشهورين جدا في إحداث الـ viral meningitis اللي هم
+
+33
+00:02:23,380 --> 00:02:27,380
+الـ Coxsackie virus و الـ echo virus بالإضافة لـ mumps 
+
+34
+00:02:27,380 --> 00:02:32,890
+virus في الـ lab diagnosis جينا الاتفاق كان على أن
+
+35
+00:02:32,890 --> 00:02:36,470
+الـ clinical diagnosis هو الأساس لكن مافيش حسمة
+
+36
+00:02:36,470 --> 00:02:40,950
+clinical diagnosis ونقطة وأول سطر لازم يكون
+
+37
+00:02:40,950 --> 00:02:45,070
+في حسمة laboratory confirmed diagnosis وغالبا في
+
+38
+00:02:45,070 --> 00:02:49,050
+الأوبئة كما ذكرنا سابقا أنه أول حالات قد يتم
+
+39
+00:02:49,050 --> 00:02:52,910
+التعامل معها مخبريا حتى نتأكد من إيه من الحالة ثم
+
+40
+00:02:52,910 --> 00:02:56,710
+بعد ذلك يتم وضع ما يسمى بالـ case description أو
+
+41
+00:02:56,710 --> 00:03:00,710
+وصف لحالة وبيتم تشخيص المرض بعد ذلك هو بشكل
+
+42
+00:03:00,710 --> 00:03:06,010
+سريري بشكل أعراض أو signs and symptoms الكلام عن
+
+43
+00:03:06,010 --> 00:03:10,670
+حاجة غريبة أيضًا في يد الفيروس هو الـ skin test وقلنا
+
+44
+00:03:10,670 --> 00:03:14,470
+لكم الـ skin test لم يَقَعْ يُستخدم لتشخيص المرض وإنما
+
+45
+00:03:14,470 --> 00:03:18,770
+يستخدم لغرض آخر ما هو هذا الغرض هو to evaluate the
+
+46
+00:03:18,770 --> 00:03:23,410
+cell mediated immunity of people يعني بنقيس مدى
+
+47
+00:03:23,410 --> 00:03:26,690
+فعالية الـ cell mediated immunity في هؤلاء الأشخاص
+
+48
+00:03:26,690 --> 00:03:33,090
+من خلال الـ mumps skin test بالنسبة للعلاج ذكرنا أنه
+
+49
+00:03:33,090 --> 00:03:38,890
+مافي علاج لهذا الفيروس و الـ prevention بتلخص
+
+50
+00:03:38,890 --> 00:03:43,390
+بالتأكيد بعملية اللي هو الـ vaccination و باستخدام
+
+51
+00:03:43,390 --> 00:03:47,730
+الـ live attenuated vaccine تو immunization جرعتين
+
+52
+00:03:47,730 --> 00:03:51,590
+الجرعة الأولى على الشهر الخامس عشر والجرعة الثانية
+
+53
+00:03:51,590 --> 00:03:55,930
+بعد أربع إلى ست سنوات وتسمى الجرعة الثانية booster
+
+54
+00:03:55,930 --> 00:03:59,730
+dose وقلنا إن هذا الـ vaccine أيضًا هو واحد من ثلاثة
+
+55
+00:03:59,730 --> 00:04:03,410
+مشتركين مع مجتمعين مع بعض اللي هم الـ measles والـ
+
+56
+00:04:03,410 --> 00:04:04,730
+mumps والـ rubella
+
+57
+00:04:06,760 --> 00:04:11,220
+وبما أنه vaccine live attenuated القاعدة العامة
+
+58
+00:04:11,220 --> 00:04:14,460
+it should not be given to immunocompromised
+
+59
+00:04:14,460 --> 00:04:18,380
+children or pregnant women للأسف أن الـ
+
+60
+00:04:18,380 --> 00:04:21,240
+immunoglobulin اللي هي الـ antibodies اللي هي الـ
+
+61
+00:04:21,240 --> 00:04:25,660
+passive immunity ليس لها فائدة في حال حدوث 
+
+62
+00:04:25,660 --> 00:04:30,280
+orchitis عند الذكور ما لها أي قيمة وأي فائدة
+
+63
+00:04:32,780 --> 00:04:35,760
+الفيروس الآخر اللي هو الـ respiratory syncytial
+
+64
+00:04:35,760 --> 00:04:39,800
+virus هذا الفيروس على النقيض من اللي قبله اللي
+
+65
+00:04:39,800 --> 00:04:41,680
+قبله احتوى على الأربع خصائص فاكرهم الخصائص
+
+66
+00:04:41,680 --> 00:04:46,040
+الأربعة؟ Hemagglutinin, Neuraminidase, fusion
+
+67
+00:04:46,040 --> 00:04:49,640
+protein و الـ hemolytic activity صح؟ هذا لا يحتوي
+
+68
+00:04:49,640 --> 00:04:54,090
+إلا على الـ fusion protein It is noted for its
+
+69
+00:04:54,090 --> 00:04:57,730
+ability to form multinucleated giant cell، هذه
+
+70
+00:04:57,730 --> 00:05:00,970
+المعلومة أصلا موجودة في كل الفيروسات اللي تحت هذه
+
+71
+00:05:00,970 --> 00:05:05,750
+المجموعة، لكن هذا أخذ الاسم syncytia هي الـ
+
+72
+00:05:05,750 --> 00:05:08,430
+multinucleated giant cell فسميها respiratory
+
+73
+00:05:08,430 --> 00:05:09,890
+syncytial virus
+
+74
+00:05:13,420 --> 00:05:17,340
+الفيروس بيسبب بعض حالات من الالتهاب الرئوي و
+
+75
+00:05:17,340 --> 00:05:21,020
+البرونكولايتس أنا بدأ أذكركم بس في شغلة مهمة أكمل
+
+76
+00:05:21,020 --> 00:05:24,080
+الفيروس لحد الآن عرفته بيسببه الـ common cold الـ
+
+77
+00:05:24,080 --> 00:05:29,620
+common cold اللي هو نزلات البرد نسمع واحد
+
+78
+00:05:43,420 --> 00:05:46,980
+الرابع هو الـ Respiratory syncytial virus هي الان
+
+79
+00:05:46,980 --> 00:05:49,700
+أربع فيروسات بسبب common cold
+
+80
+00:05:52,060 --> 00:05:55,680
+It is also an important cause of otitis media يعني
+
+81
+00:05:55,680 --> 00:05:58,800
+التهاب الأذن الوسطى أيضًا ممكن يسببه بعض الفيروسات
+
+82
+00:05:58,800 --> 00:06:04,200
+مثل هذا الفيروس كمان بيعمل التهاب رئوي خاصة في الكبار
+
+83
+00:06:04,200 --> 00:06:08,940
+السن أو مما لديهم أمراض cardiopulmonary disease
+
+84
+00:06:08,940 --> 00:06:13,420
+يعني عندهم مشكلة في القلب وفي الرئتين زي chronic
+
+85
+00:06:13,420 --> 00:06:18,220
+diseases في الـ lungs من الخصائص اللي عامة يلو إن هو
+
+86
+00:06:18,220 --> 00:06:22,380
+ده الفيروس زي وزي أي other paramyxovirus من ناحية
+
+87
+00:06:22,380 --> 00:06:25,500
+إيش؟ من ناحية المادة الوراثية المادة الوراثية إيش
+
+88
+00:06:25,500 --> 00:06:32,040
+محتوية؟ محتوية على single strand من negative sense
+
+89
+00:06:32,040 --> 00:06:38,950
+RNA الكبسيد helical و Enveloped تمام يبقى هو 
+
+90
+00:06:38,950 --> 00:06:43,190
+typical باراميكسوفيروس من هذه الناحية وبيحتوي
+
+91
+00:06:43,190 --> 00:06:47,310
+على RNA dependent RNA polymerase وبتالي الجينوم
+
+92
+00:06:47,310 --> 00:06:52,450
+تبعه not infectious non infectious جينوم وقلنا
+
+93
+00:06:52,450 --> 00:06:56,270
+لكم بيحتوي فقط على اللي هو الـ fusion protein ولا
+
+94
+00:06:56,270 --> 00:06:58,490
+يحتوي على الـ hemagglutinin ولا يحتوي على الـ
+
+95
+00:06:58,490 --> 00:07:02,730
+neuraminidase وقلنا لكم مشهور أيضًا بأنه بيكون
+
+96
+00:07:02,730 --> 00:07:07,700
+multi nucleated giant cell لسنوات عديدة كان
+
+97
+00:07:07,700 --> 00:07:11,400
+الاعتقاد السائد أن هذا الفيروس يحتوي فقط على one
+
+98
+00:07:11,400 --> 00:07:17,020
+strain مؤخرًا تم اكتشاف أنه بيحتوي على two strains
+
+99
+00:07:17,020 --> 00:07:22,260
+سموهم subgroup A و subgroup B وهذا الاكتشاف كان من
+
+100
+00:07:22,260 --> 00:07:25,760
+خلال أن وظفنا different monoclonal antibodies
+
+101
+00:07:25,760 --> 00:07:29,080
+للعلم من الفئة الملاجئة أنه في بعض الاختلافات في
+
+102
+00:07:29,080 --> 00:07:34,500
+السلالتين مش سلالة واحدة على الرغم من أنه سلالتين و
+
+103
+00:07:34,500 --> 00:07:37,520
+سلالة واحدة مش حاجة كبيرة وده لأ يعني ممكن نعملهم
+
+104
+00:07:37,520 --> 00:07:41,440
+vaccine لكن للأسف مافيش vaccine لهذا الـ virus
+
+105
+00:07:41,440 --> 00:07:46,740
+بالعكس لما حاولنا نعمل vaccine الناس اللي طعمناهم
+
+106
+00:07:46,740 --> 00:07:50,100
+صارت severity of the disease أسوأ من اللي ما
+
+107
+00:07:50,100 --> 00:07:56,140
+طعمناهموش هنشرح لكم كل الكلام الآن بشكل واضح عشان
+
+108
+00:07:56,140 --> 00:07:59,820
+نفهمه ونعرف أنه في بعض الأحيان الـ
+
+109
+00:07:59,820 --> 00:08:05,480
+immunopathogenesis بيكون أخطر من الـ virus itself و
+
+110
+00:08:05,480 --> 00:08:09,580
+هذا عبارة عن immunopathogenesis بيكون اسمع علوة
+
+111
+00:08:09,580 --> 00:08:12,700
+مني الآن كمان إضافية عشان نقدر نوصل الرسالة تبعتنا
+
+112
+00:08:12,700 --> 00:08:19,340
+أن هذا الـ virus تقريبًا بيصيب كل البشر في عمر تلات
+
+113
+00:08:19,340 --> 00:08:23,040
+سنوات يعني لما احنا بنبلغ عمر تلات سنوات شبه مؤكد
+
+114
+00:08:23,040 --> 00:08:26,720
+أن احنا نكون أصيبنا بهذا الـ virus على الأقل مرة
+
+115
+00:08:26,720 --> 00:08:34,700
+واحد يبقى واسع الانتشار وله ميزة كمان في انتشاره
+
+116
+00:08:34,700 --> 00:08:39,020
+انتشاره غريب بيروسات الرشحة الأخرى اللي ذكرناهم
+
+117
+00:08:39,020 --> 00:08:46,260
+تمام ميزتهم أنهم بيدخلوا كل شتاء كل winter يعني كل
+
+118
+00:08:46,260 --> 00:08:51,760
+فصل شتاء على الـ .. الـ .. الـ outbreaks كل سنتين أو
+
+119
+00:08:51,760 --> 00:08:54,420
+ثلاثة بيدخلوا في الـ cycle يعني الواحد اللي عمل
+
+120
+00:08:54,420 --> 00:08:57,680
+السنة هذه بيِرتاح سنة سنتين ثلاثة وبعدين بيعمل cycle
+
+121
+00:08:57,680 --> 00:09:04,300
+بعد سنتين ثلاثة هذا الـ virus لازم كل شتاء كل فصل
+
+122
+00:09:04,300 --> 00:09:11,890
+شتاء بيعمل infection إذا هو common بيصيب بنسبة كبيرة
+
+123
+00:09:11,890 --> 00:09:18,790
+قد تصل إلى 100% من الأطفال by the age of 3 طيب وين
+
+124
+00:09:18,790 --> 00:09:21,890
+خطورة .. وين خطورة الفيروس والـ
+
+125
+00:09:21,890 --> 00:09:25,790
+immunopathogenesis؟ الآن بما أن احنا كلنا أصيبنا 
+
+126
+00:09:25,790 --> 00:09:29,770
+يبقى أبناءكم برضه شمالهم هيكون لأ هيكون عندهم
+
+127
+00:09:29,770 --> 00:09:33,790
+antibody لأن أنتم عندكم تكون antibodies من
+
+128
+00:09:33,790 --> 00:09:36,710
+الإثارة الأولانية الأسئلة اللي وصبتوا فيها فينكم
+
+129
+00:09:36,710 --> 00:09:42,050
+antibodies فتنقلوها إلى أطفالكم، كمان ال antibody
+
+130
+00:09:42,050 --> 00:09:45,010
+المفروض أنه حاجة كويسة بدلها بدل حاجة كويسة يعني
+
+131
+00:09:45,010 --> 00:09:48,750
+المفروض نكون فرحين بأنه صار فيها أنها antibody
+
+132
+00:09:48,750 --> 00:09:54,970
+عند الطفل لأن لو ال virus دخل ال lungs بتاعت الطفل
+
+133
+00:09:54,970 --> 00:10:01,150
+ال antibodies بتحاول تهاجم من ال virus فبيتكون
+
+134
+00:10:01,150 --> 00:10:05,710
+ينتج ينتج antibody complex للأسف هو بينتج في ال
+
+135
+00:10:05,710 --> 00:10:09,470
+lungs وبصير في activation لل complement وبصير في 
+
+136
+00:10:09,470 --> 00:10:16,210
+attack لـ lung cells أي خلية بتموت، هو تعبير وإشارة
+
+137
+00:10:16,210 --> 00:10:18,750
+للخلايا الأخرى اللي لازم منها بيجيوا يعرفوا إيش
+
+138
+00:10:18,750 --> 00:10:22,130
+السبب، إذا كانت المشكلة بيحلوها، فبيتكون برضه
+
+139
+00:10:22,130 --> 00:10:26,590
+immune storm في منطقة ال lungs وبالتالي ال severity
+
+140
+00:10:26,590 --> 00:10:31,090
+of disease بتكون أعلى وهذا ما حدث عندما قمنا
+
+141
+00:10:31,090 --> 00:10:35,810
+بإعطاء الأطفال vaccine عطيناهم vaccine بفيروس ميت
+
+142
+00:10:35,810 --> 00:10:39,350
+فكوّنوا أجسام مضادة لأن لما اتعرض هو للـ infection
+
+143
+00:10:39,350 --> 00:10:44,650
+كان عنده كم كبير من الأجسام المضادة تفاعلت كمان
+
+144
+00:10:44,650 --> 00:10:48,090
+مرة مع الفيروس وبالتالي أحدثت ضرر بشكل أكبر
+
+145
+00:10:48,090 --> 00:10:53,510
+وبالتالي ال vaccine الآن لا يستخدم مع هذه ال
+
+146
+00:10:53,510 --> 00:10:57,170
+disease هذا واحد، وهذا السبب أن احنا ما عملناش
+
+147
+00:10:57,170 --> 00:11:00,510
+vaccination مش لأنه two strains لأ ما في مشكلة أن
+
+148
+00:11:00,510 --> 00:11:03,670
+نكون two strains أساسا ما هي ال polio ثلاثة strains
+
+149
+00:11:03,670 --> 00:11:10,890
+ومع ذلك شغالين فيه، السبب الثاني غير اللي ذكرناها
+
+150
+00:11:10,890 --> 00:11:15,490
+هذا أنه بيعمل immune complexes أن في عندي مشكلة
+
+151
+00:11:15,490 --> 00:11:21,510
+حقيقية أن الجهاز المناعي ردت فعله ضد هذا الفيروس
+
+152
+00:11:21,510 --> 00:11:26,650
+incomplete كيف أعرف إنه incomplete؟ أقول لك الشخص
+
+153
+00:11:26,650 --> 00:11:31,390
+الواحد قد يصاب بهذا الفيروس عدة مرات خلال فترة
+
+154
+00:11:31,390 --> 00:11:35,950
+الطفولة يعني ما فيش مناعة طول الأمد، مناعة إما
+
+155
+00:11:35,950 --> 00:11:40,570
+قصيرة أو غير مكتملة وبالتالي الفاكسين لو احنا نجحنا
+
+156
+00:11:40,570 --> 00:11:43,850
+بأنه ما كانش فيه immunopathogenesis واضح أن
+
+157
+00:11:43,850 --> 00:11:48,770
+الفاكسين ما بيعطيش complete immunity ضد هذا الفيروس
+
+158
+00:11:48,950 --> 00:11:52,710
+إذن هذا الفيروس له خلينا نقول مزايا مختلفة عن ال
+
+159
+00:11:52,710 --> 00:11:57,230
+other viruses انتشاره الواسع 100% من الناس اللي
+
+160
+00:11:57,230 --> 00:12:00,030
+أتصاب فيه، رقم 2 ما لهوش vaccine وعرفنا ليش ما لهوش
+
+161
+00:12:00,030 --> 00:12:03,770
+vaccine وعرفنا أن ال pathogenesis تبعته مركز على
+
+162
+00:12:03,770 --> 00:12:08,270
+ال immunopathogenesis أكثر ما هو مركز على ال virus
+
+163
+00:12:08,270 --> 00:12:09,090
+itself
+
+164
+00:12:12,710 --> 00:12:15,350
+الجولة الأخيرة في اللوحة هذه، Antibody against the
+
+165
+00:12:15,350 --> 00:12:19,450
+fusion protein neutralizes infectivity إيش يعني
+
+166
+00:12:19,450 --> 00:12:23,470
+infectivity؟ قدرة الفيروس أنه يعمل infection لـ ال
+
+167
+00:12:23,470 --> 00:12:28,410
+other cells هذا برضه ميزة جيدة لكن للأسف كمان مرة
+
+168
+00:12:28,410 --> 00:12:34,700
+هو بيرتبط مع ال antigen مع ال fusion protein هو
+
+169
+00:12:34,700 --> 00:12:38,240
+عبارة عن immune complexes وبالتالي هو بيمنع
+
+170
+00:12:38,240 --> 00:12:41,440
+الفيروس من أنه يصيب يصيب خلايا ال lungs لكن بيعمل
+
+171
+00:12:41,440 --> 00:12:44,340
+activation لمن؟ لل complement وبالتالي بدمر خلايا
+
+172
+00:12:44,340 --> 00:12:49,020
+ال lungs ففي الحالتين الفيروس دخل بدمر ما دخل أيضًا
+
+173
+00:12:49,020 --> 00:12:54,620
+بيدمر هذه
+
+174
+00:12:54,620 --> 00:12:58,420
+كلها كلام مكرر من اللي ذكرناها، معدي الفقرة الأخيرة
+
+175
+00:12:59,810 --> 00:13:02,770
+الـ RSV اللي هو Respiratory Sensitive Virus also
+
+176
+00:13:02,770 --> 00:13:05,350
+causes outbreaks of respiratory infection in
+
+177
+00:13:05,350 --> 00:13:08,150
+hospitalized infants يعني أطفال منومين في
+
+178
+00:13:08,150 --> 00:13:12,750
+المشافي، في المستشفيات، بيعمل بينهم تفشيات تخيلوا
+
+179
+00:13:12,750 --> 00:13:17,330
+ال infants، هنعرف كمان شوية أنه ال severity فيهم
+
+180
+00:13:17,330 --> 00:13:21,690
+أعلى من الآخرين، إيش السبب؟ أنه لسه بيحتووا على
+
+181
+00:13:21,690 --> 00:13:24,650
+مين؟ على antibodies من اللي هو ال maternal
+
+182
+00:13:24,650 --> 00:13:29,510
+antibodies، وبالتالي إذا كان فيه hospitalized infants
+
+183
+00:13:29,510 --> 00:13:34,630
+وصار outbreak لازم نتخذ كل الإجراءات الملائمة للحد
+
+184
+00:13:34,630 --> 00:13:39,870
+من انتشار العدوى، وأهم إجراءين في منع العدوى هم
+
+185
+00:13:39,870 --> 00:13:45,250
+غسل اليدين بالطريقة الصحيحة ولبس اللي هو ال gloves
+
+186
+00:13:45,250 --> 00:13:50,470
+بشكل سليم أيضًا، كمان مرة لبس ال gloves بشكل سليم مش
+
+187
+00:13:50,470 --> 00:13:53,310
+بجرد نلبس ال gloves وانتهى عن الموضوع، وأنا ممكن
+
+188
+00:13:53,310 --> 00:13:57,650
+ذكرتلكم في أكثر من موقف ممكن في مساقات أخرى أن
+
+189
+00:13:57,650 --> 00:14:02,350
+مصطلح ما يسمى بالـ false sense of security الشعور
+
+190
+00:14:02,350 --> 00:14:10,750
+الكاذب بالأمان، ووضحتلكم بمثال سيارة اللي بيقودها
+
+191
+00:14:10,750 --> 00:14:17,830
+شخص تمام وعلى المقود في سكين موجه باتجاه السائق
+
+192
+00:14:17,830 --> 00:14:23,810
+وفي أمام السائق من السيارة من الأمام لغم تمام؟
+
+193
+00:14:23,810 --> 00:14:27,910
+موصول بـ C حديد طويل وفي الخلف أيضًا لغم مكتبين
+
+194
+00:14:27,910 --> 00:14:31,770
+على السيارة، هي السيارة الأكثر أمانًا في العالم، فطبعًا البعض
+
+195
+00:14:31,770 --> 00:14:35,970
+بيضحك وبيستهزق بهذا الكاريكاتير وبيقول كيف هي
+
+196
+00:14:35,970 --> 00:14:42,430
+سيارة أمن وفيها خنجر أو سكين، لو ضرب بريك السائق
+
+197
+00:14:42,430 --> 00:14:46,430
+هتغزه في صدره، لو اقترب من سيارة أخرى السيخ هيضرب
+
+198
+00:14:46,430 --> 00:14:49,310
+في السيارة وهتنفجر، ولو اقتربت في سيارة من الخلف
+
+199
+00:14:49,310 --> 00:14:54,570
+أيضًا كذلك الأمر هينفجر، إذا كيف هي أمن سيارة؟ شعور
+
+200
+00:14:54,570 --> 00:14:59,590
+السائق باللي أنا ذكرته هذا هيجعله إيش؟ معاه متيقظ وحذر
+
+201
+00:14:59,590 --> 00:15:03,830
+حذر، هينظر إلى الخلف وهينظر للأمام ولن يسرع بشكل
+
+202
+00:15:03,830 --> 00:15:09,410
+كبير وبالتالي بيكون خائفًا فحذرًا فسلام، لكن تعالوا
+
+203
+00:15:09,410 --> 00:15:12,890
+تطلعوا على السيارات، السيارات الحديثة بقولك أن فيها
+
+204
+00:15:12,890 --> 00:15:18,630
+نظام إنذار للاصطدام وفيها airbag وفيها وكده و
+
+205
+00:15:18,630 --> 00:15:23,170
+مع ذلك نسبة الحوادث زادت، ونسبة الوفيات من هذه
+
+206
+00:15:23,170 --> 00:15:27,710
+الحوادث زادت، ليش؟ لأنه شعر بأنه فيه أمان، فلما
+
+207
+00:15:27,710 --> 00:15:33,070
+شعر بأمان استهتر وبالتالي أخطأ، الآن هذا ينطبق
+
+208
+00:15:33,070 --> 00:15:36,090
+تمامًا على لبسنا ال gloves في المستشفيات وال
+
+209
+00:15:36,090 --> 00:15:39,730
+infection control كثير من الناس اللي نشوفهم في
+
+210
+00:15:39,730 --> 00:15:44,050
+المعامل، لابس gloves ولابس المريول وماسك الجوال
+
+211
+00:15:44,050 --> 00:15:48,050
+وبيعمل نت وبمسك الأقلام تبعته وبكتف فيها والشنط
+
+212
+00:15:48,050 --> 00:15:52,490
+تبعته وبدور فيها وبمسك المساحة بال gloves وكأنه
+
+213
+00:15:52,490 --> 00:15:57,830
+إيه؟ وكأنه مدام لابس gloves يبقى protected، لأ مش
+
+214
+00:15:57,830 --> 00:16:03,340
+protected إذا ما اشتغلناش بال gloves صح بنكون مش بس
+
+215
+00:16:03,340 --> 00:16:06,760
+مش protected احنا بننقل العدوى ده، هأحكيلكم إيش
+
+216
+00:16:06,760 --> 00:16:12,120
+تجربة أحد الشركات الـ الـ الـ الـ الـ biotech عملت
+
+217
+00:16:12,120 --> 00:16:19,260
+مع الموظفين المحتملين، جابوهم، كتاب صغير دليل ما هي
+
+218
+00:16:19,260 --> 00:16:22,860
+الأماكن اللي هيروحوا عليها في الـ الـ الـ غرفة
+
+219
+00:16:22,860 --> 00:16:25,820
+الكبيرة الواسعة وإيش يشتغلوا، تجارب بسيطة عاملينها
+
+220
+00:16:25,820 --> 00:16:29,850
+تجارب بسيطة زي تجارب كفيل معامل، بس الفرق إنهم حطو لهم
+
+221
+00:16:29,850 --> 00:16:34,750
+على إيد الباب لما دخلوا حطو لهم مادة بتنشّاف بال
+
+222
+00:16:34,750 --> 00:16:37,650
+ultra fluorescent بتنشّاف بال ultra violet light
+
+223
+00:16:37,650 --> 00:16:43,130
+تمام؟ فكل واحد دخل الباب مسك الأكره يبقى مسك معه
+
+224
+00:16:43,130 --> 00:16:48,160
+أشلان أخد جزء من إيه؟ المادة، وبعد أربع ساعات من
+
+225
+00:16:48,160 --> 00:16:54,900
+دخولهم للقاع، طفوا ضوء ووقفوا الشغل، طفوا الأضواء
+
+226
+00:16:54,900 --> 00:16:58,360
+وشغلوا نوع من ال ultraviolet light غير مؤذي بس
+
+227
+00:16:58,360 --> 00:17:01,840
+بكشف عن الفلوريسين لكم، أنت تخيلوا وين لقوا
+
+228
+00:17:01,840 --> 00:17:06,080
+الفلوريسين في شعرهم في جرابينهم في أيديهم في
+
+229
+00:17:06,080 --> 00:17:10,960
+ملابسهم الداخلية، حتى لقوا موجود الفلوريسين مع أنه
+
+230
+00:17:10,960 --> 00:17:14,960
+مش مالهم، كلهم دخلوا لبسوا gloves ولبسوا ياش مرايل
+
+231
+00:17:15,750 --> 00:17:21,130
+الذين أظهروا أقل تلوث في أجسامهم، في البيئة
+
+232
+00:17:21,130 --> 00:17:25,210
+تبعاتهم، هم الذين اختيروا لهذه الوظيفة، يعرفوا
+
+233
+00:17:25,210 --> 00:17:28,470
+يعني أن لابسين ال gloves ليش لابسين ال gloves؟ To
+
+234
+00:17:28,470 --> 00:17:31,110
+protect themselves, to protect the environment, to
+
+235
+00:17:31,110 --> 00:17:37,040
+protect others هذا هو الغرض وبالتالي الـ الـ الـ
+
+236
+00:17:37,040 --> 00:17:40,700
+infection control أحد أساسيته غسل الأيادي بطريقة
+
+237
+00:17:40,700 --> 00:17:44,080
+صحيحة والثانية اللي هي بنا لبس ال gloves بين أو ال
+
+238
+00:17:44,080 --> 00:17:46,880
+changing لـ gloves بين patient و patient آخر
+
+239
+00:17:53,650 --> 00:17:57,610
+برضه تقريبًا في هذه اللوحة كل ما ذكر فيها ذكرناها
+
+240
+00:17:57,610 --> 00:18:02,250
+إلا الجملة الأخيرة وهي لماذا تزداد مناعتنا ضد هذا
+
+241
+00:18:02,250 --> 00:18:05,820
+الفيروس عندما نكبر؟ غالبًا جهاز المناعة التلقائي
+
+242
+00:18:05,820 --> 00:18:11,120
+بيحسن قدرته على إنتاج اللي هو ال IGA وال IGA هو
+
+243
+00:18:11,120 --> 00:18:14,860
+غير عن ال IGG، ال IGA لا ينشط بناء ال complement
+
+244
+00:18:14,860 --> 00:18:18,780
+بينشطش ال complement، مين بينشط ال complement؟ ال IGG
+
+245
+00:18:18,780 --> 00:18:22,520
+وال IGM كلاهما بينشطوا ال complement هذا ما بينشطش
+
+246
+00:18:22,520 --> 00:18:27,300
+وبالتالي وين موجود؟ موجود في ال secretory أو في ال
+
+247
+00:18:27,300 --> 00:18:30,240
+secretions اللي من ضمنها ال mucus وبالتالي هو بيعمل
+
+248
+00:18:30,240 --> 00:18:35,760
+protection من الفيروس بطريقة لا تؤذي أيضًا أو لا
+
+249
+00:18:35,760 --> 00:18:41,900
+تنشط جهاز المناعة In
+
+250
+00:18:41,900 --> 00:18:45,540
+infants, RSV is an important cause of lower 
+
+251
+00:18:45,540 --> 00:18:48,700
+respiratory tract disease such as bronchiolitis and
+
+252
+00:18:48,700 --> 00:18:51,940
+pneumonia وممكن في الـ young children يعني الـ
+
+253
+00:18:51,940 --> 00:18:55,340
+otitis media كما ذكرنا، في ال children and young
+
+254
+00:18:55,340 --> 00:18:56,340
+healthy adults
+
+255
+00:19:00,970 --> 00:19:05,670
+الناس عندهم مناعة منخفضة ولكن ناس عاديين RSV causes
+
+256
+00:19:05,670 --> 00:19:08,930
+the respiratory tract infections such as common
+
+257
+00:19:08,930 --> 00:19:15,250
+cold and bronchitis في الكبار السن اللي هم أكبر من
+
+258
+00:19:15,250 --> 00:19:18,850
+65 سنة and in adults with chronic cardiopulmonary
+
+259
+00:19:18,850 --> 00:19:21,510
+diseases يعني هو بسبب مش cardiopulmonary disease
+
+260
+00:19:21,510 --> 00:19:24,470
+لو هو بسبب مرض في اللي عندهم cardiopulmonary
+
+261
+00:19:24,470 --> 00:19:28,710
+disease RSV causes severe lower respiratory tract
+
+262
+00:19:28,710 --> 00:19:32,690
+disease including pneumonia لأ لأ لأ إذا بتلاحظوا
+
+263
+00:19:32,690 --> 00:19:36,750
+معظم المحاضرة بنركز على مين هنا على ال pneumonia
+
+264
+00:19:36,750 --> 00:19:40,970
+الناجمة عن هذا ال virus لأن ال pneumonia is more
+
+265
+00:19:40,970 --> 00:19:43,850
+dangerous than other respiratory tract infection
+
+266
+00:19:43,850 --> 00:19:47,230
+من
+
+267
+00:19:47,230 --> 00:19:50,970
+الفحوصات المستخدمة لل diagnosis طبعا شفتوا ال
+
+268
+00:19:50,970 --> 00:19:55,030
+measles كان لها أعراض واضحة ال mumps كان له أعراض
+
+269
+00:19:55,030 --> 00:19:58,930
+واضحة لكن هذا مالوش أعراض تشترك أعراضه بيه مع
+
+270
+00:19:58,930 --> 00:20:04,380
+ميكروبات أخرى لذا الكلام الواجب علينا أنه نتعرف على
+
+271
+00:20:04,380 --> 00:20:08,680
+الفيروس من خلال rapid antigen test بيستخدم ووظف
+
+272
+00:20:08,680 --> 00:20:14,340
+تقنية ال Immuno Assay وبيكشف عن الفيروس في ال
+
+273
+00:20:14,340 --> 00:20:17,100
+respiratory secretions زي ال nasal secretion أو من
+
+274
+00:20:17,100 --> 00:20:20,460
+عينة Sputum ممكن أيضا يتم الكشف عن الفيروس
+
+275
+00:20:20,460 --> 00:20:24,140
+باستخدام immunofluorescence أما من ال Epithelial
+
+276
+00:20:24,140 --> 00:20:27,120
+tissue اللي طالع مع ال Sputum أو من خلال ال
+
+277
+00:20:27,120 --> 00:20:32,590
+isolation في cell culture أهم CPE في الـ Cell
+
+278
+00:20:32,590 --> 00:20:35,550
+Culture بنشوف اللي هو مين؟ الـ Multi-Nucleated
+
+279
+00:20:35,550 --> 00:20:40,590
+Giant Cell أو اللي يكون عنه Syncytial أيضا لا
+
+280
+00:20:40,590 --> 00:20:44,510
+يختلف عن أخوته من الفيروس الأخرى في موضوع الـ
+
+281
+00:20:44,510 --> 00:20:48,150
+Detection للـ Antibody Fourfold Increase، إيش يعني
+
+282
+00:20:48,150 --> 00:20:54,090
+Fourfold؟ زيادة تيتر تبع ال antibody بأربعة أضعاف
+
+283
+00:20:54,090 --> 00:20:59,150
+بين ال acute sample أو ال specimen و ال
+
+284
+00:20:59,150 --> 00:21:02,570
+convalescent specimen اللي بينهم مدة من عشرة إلى
+
+285
+00:21:02,570 --> 00:21:06,770
+أربعة عشر يوم ما بين العينة الأولى و الثانية وأيضا
+
+286
+00:21:06,770 --> 00:21:11,010
+نذكر مرة أخرى بأنه من يوم من ال zero time اللي
+
+287
+00:21:11,010 --> 00:21:13,130
+احنا خدنا فيه العينة لأربعة عشر يوم بيكون المريض
+
+288
+00:21:13,130 --> 00:21:18,150
+أشملته شوفية فبالتالي الفحص هنا just to confirm
+
+289
+00:21:18,150 --> 00:21:22,560
+the case هل ترى ال confirmation هذا بيستحق أنه نجري
+
+290
+00:21:22,560 --> 00:21:26,380
+الفحص مرتين؟ نعم يستحق عشان نقدر نعرف بالفعل ال
+
+291
+00:21:26,380 --> 00:21:30,080
+exact etiology هل احنا كنا بنعالج في disease صح
+
+292
+00:21:30,080 --> 00:21:35,500
+ولا ممكن يكون other disease واختفى لوحده طبعا هذا
+
+293
+00:21:35,500 --> 00:21:39,760
+دخل على الصحة معانا فحص جديد اللي هو اسمه RT-PCR
+
+294
+00:21:39,760 --> 00:21:43,260
+أو reverse transcriptase polymerase chain reaction
+
+295
+00:21:43,260 --> 00:21:49,080
+متاح لهذا الفيروس بالنسبة للعلاج لدينا
+
+296
+00:21:49,080 --> 00:21:55,860
+antiviral اسمه ribavirin، ال ribavirin ما بنعطيهوش
+
+297
+00:21:55,860 --> 00:21:59,280
+injection في هذه الحالة، بنعطيه زي بخاخة
+
+298
+00:21:59,280 --> 00:22:05,460
+aerosolized عشان بنرشه عشان يصل لل lungs لمن
+
+299
+00:22:05,460 --> 00:22:11,160
+نعطي فقط for severely ill infants يعني الرضع اللي
+
+300
+00:22:11,160 --> 00:22:16,320
+عندهم المرض حاد بشكل كبير جدا اقرأ الجملة اللي
+
+301
+00:22:16,320 --> 00:22:19,880
+بعديها إيش بتقول but there is uncertainty
+
+302
+00:22:19,880 --> 00:22:24,800
+regarding its effectiveness يعني هناك شكوك حول
+
+303
+00:22:24,800 --> 00:22:29,900
+فعالية هذا ال antiviral drug a combination of
+
+304
+00:22:29,900 --> 00:22:33,670
+ribavirin and hyper immunoglobulin كلمة hyper
+
+305
+00:22:33,670 --> 00:22:36,470
+immunoglobulin أخذناها في ال passive immunity أنه
+
+306
+00:22:36,470 --> 00:22:40,650
+solution بيحتوي على تركيز عالي من إيه؟ من ال
+
+307
+00:22:40,650 --> 00:22:45,250
+immunoglobulin against RSV maybe more effective
+
+308
+00:22:45,250 --> 00:22:51,390
+لحظة الجملتين maybe والأولانية أشمالها uncertainty
+
+309
+00:22:51,390 --> 00:22:57,600
+هل هذه لغة تفهمونها أنتم؟ يعني لو واحد قد سألني
+
+310
+00:22:57,600 --> 00:23:02,060
+جالي مين أحسن أخد ال .. ال ribavirin ولا ribavirin
+
+311
+00:23:02,060 --> 00:23:05,660
+and hyper immunoglobulin أنا بصفتي microbiologist
+
+312
+00:23:05,660 --> 00:23:10,340
+ما بقولكم مش هعرف لكن بصفتي طبيب لو أنا ده أكون طبيب
+
+313
+00:23:10,340 --> 00:23:15,900
+لازم أجاوبكم و أعطيكم الخيارات أعطيكم خيارات إذا
+
+314
+00:23:15,900 --> 00:23:18,980
+هذه اللغة المستخدمة هي لغة العلماء لغة العلم
+
+315
+00:23:18,980 --> 00:23:23,750
+والعلماء تختلف عن لغة الخدمات لغة الخدمات غالبا
+
+316
+00:23:23,750 --> 00:23:28,030
+بنحب تكون قطعية بأرقام، مزودة بأرقام، وده أعطي مثال
+
+317
+00:23:28,030 --> 00:23:32,710
+... مثال صغير على اللغة العلمية من السلف الصالح،
+
+318
+00:23:32,710 --> 00:23:35,650
+أنا لأ ... لأ ... لست متأكدا عن من قال هذه العبارة،
+
+319
+00:23:35,650 --> 00:23:40,460
+لكن أظنه الإمام الشافعي رحمه الله رأي صواب يحتمل
+
+320
+00:23:40,460 --> 00:23:46,960
+الخطأ ورأيك خطأ يحتمل الصواب لحظة هو شبه متأكد من
+
+321
+00:23:46,960 --> 00:23:50,980
+رأيه إلا أنه ترك مجال لل uncertainty لل maybe
+
+322
+00:23:50,980 --> 00:23:57,820
+فاهم؟ ومتأكد أيضا من خطأ الرأي اللي أمامه لكن أيضا
+
+323
+00:23:57,820 --> 00:24:03,400
+ترك مجال إنه ممكن يكون صواب هذه لغة العلم لغة غير
+
+324
+00:24:03,400 --> 00:24:06,760
+قطعية وأنا أرجو من حضراتكم أنكم تستوعبوا هذا
+
+325
+00:24:06,760 --> 00:24:10,810
+المصطلح maybe uncertain I'm not sure هذه كلها
+
+326
+00:24:10,810 --> 00:24:14,750
+اللغات اللغة لا تنقص من قدر قائلها شيئا يعني
+
+327
+00:24:14,750 --> 00:24:19,770
+تعلموا أن تقولوا لا أدري لا أعرف ربما غير متأكد
+
+328
+00:24:19,770 --> 00:24:25,490
+هذه هذه المصطلحات بس في الامتحان لا طبعا لست متأكدا
+
+329
+00:24:25,490 --> 00:24:30,390
+أنا من أن أي دي بدي دقيقة هذا يعتبر خدمات ... يعتبر
+
+330
+00:24:30,390 --> 00:24:34,490
+خدمات ... وصل الصورة أرجو ... أرجو أن اللغة العلمية
+
+331
+00:24:34,490 --> 00:24:38,850
+تسود يعني في مجتمعنا لأنها هي اللغة الكفيلة بتغيير
+
+332
+00:24:38,850 --> 00:24:43,320
+سلوك الناس طيب ال prevention هنقول أنه ما فيش
+
+333
+00:24:43,320 --> 00:24:49,120
+vaccine متاح لهذا ال virus وذكرنا أنه كان في
+
+334
+00:24:49,120 --> 00:24:52,760
+محاولات سابقة باستخدام ال killed vaccine ... ال
+
+335
+00:24:52,760 --> 00:24:58,720
+killed vaccine زادت من سوء حالة المرضى بشكل كبير
+
+336
+00:24:58,720 --> 00:25:03,910
+جدا لكن في immunoglobulins زي ما ذكرنا وفي منها
+
+337
+00:25:03,910 --> 00:25:08,550
+تحضيرات مختلفة وتعطي يعني كبروفيلاكسز خاصة في ال
+
+338
+00:25:08,550 --> 00:25:11,950
+premature babies وين ال premature babies بيكونوا؟
+
+339
+00:25:12,890 --> 00:25:16,390
+في الحاضنة أنصحها تذكروا قبل قليل تحدثنا عن
+
+340
+00:25:16,390 --> 00:25:21,330
+outbreaks للإنفلونزا فلما يكونوا premature أساسا
+
+341
+00:25:21,330 --> 00:25:25,530
+تمام؟ premature عندهم أول حاجة مناعتهم ضعيفة وعندهم
+
+342
+00:25:25,530 --> 00:25:29,090
+أصلا immunoglobulin maternal antibody وبتالي
+
+343
+00:25:29,090 --> 00:25:33,350
+إمكانية أن تكون ال disease فيهم severe عالية جدا
+
+344
+00:25:33,350 --> 00:25:37,610
+فيُمكن إعطاؤهم في هذه الحالة immunoglobulin
+
+345
+00:25:39,840 --> 00:25:43,940
+hyperimmunoglobulin أيضا يُستخدم كبروفيلاكسس في
+
+346
+00:25:43,940 --> 00:25:46,980
+الرضع and in children with chronic lung disease
+
+347
+00:25:46,980 --> 00:25:51,420
+نوزوكوميا ال outbreaks could be prevented by hand
+
+348
+00:25:51,420 --> 00:25:57,930
+washing and wearing gloves أو using gloves طبعا
+
+349
+00:25:57,930 --> 00:26:00,870
+بالخطأ مكرر هذا الفيروس اللي أنا بتكلم عن ال
+
+350
+00:26:00,870 --> 00:26:05,850
+Parainfluenza viruses ال Parainfluenza مين أخوهم
+
+351
+00:26:05,850 --> 00:26:10,090
+من الفيروسات ال mumps ال mumps و ال Parainfluenza
+
+352
+00:26:10,090 --> 00:26:15,550
+كانوا هما الاثنين تحت عنوان اسمه Paramyocovirus طبعا
+
+353
+00:26:15,550 --> 00:26:19,150
+لسه
+
+354
+00:26:19,150 --> 00:26:20,550
+ذاكرين التصنيفات هذه
+
+355
+00:26:23,340 --> 00:26:28,140
+parainfluenza viruses disease these viruses causes
+
+356
+00:26:28,140 --> 00:26:34,580
+croup croup لسه متأكدا أيضا من المعنى باللغة
+
+357
+00:26:34,580 --> 00:26:40,080
+العربية ولكن هو نوع من الكحة الجافة يعني الجافة
+
+358
+00:26:40,080 --> 00:26:47,040
+تماماً ومزعجة جداً لحتى لمستمع الشخص اللي بيسمعها
+
+359
+00:26:47,040 --> 00:26:55,430
+لأن صوت الكحة بيكون بالفعل جاف جداً و للغاية Acute
+
+360
+00:26:55,430 --> 00:26:58,150
+laryngobronchitis، laryngitis، bronchiolitis و
+
+361
+00:26:58,150 --> 00:27:03,030
+pneumonia وفي الأطفال و ... أو ... أو ... أو ... أو ...
+
+362
+00:27:03,030 --> 00:27:04,330
+أو ... أو ... أو ... أو ... أو ... أو ... أو ... أو ...
+
+363
+00:27:04,330 --> 00:27:06,950
+... أو ... أو ... أو ... أو ... أو ... أو ... أو ...
+
+364
+00:27:06,950 --> 00:27:07,770
+أو ... أو ... أو ... أو ... أو ... أو ... أو ... 
+
+365
+00:27:07,770 --> 00:27:08,070
+... أو ... أو ... أو ... أو ... أو ... أو ... 
+
+366
+00:27:08,070 --> 00:27:08,210
+أو ... أو ... أو ... أو ... أو ... أو ... 
+
+367
+00:27:08,210 --> 00:27:09,130
+... أو ... أو ... أو ... أو ... أو ... 
+
+368
+00:27:09,130 --> 00:27:15,210
+أو ... أو ... أو ... أو ... 
+
+369
+00:27:15,210 --> 00:27:18,330
+... أو ... ا
+
+370
+00:27:21,160 --> 00:27:25,640
+من خصائص هذا الفيروس أن الـ spikes فيها haem
+
+371
+00:27:25,640 --> 00:27:30,820
+agglutinin، neuraminidase، و fusion protein الـ fusion
+
+372
+00:27:30,820 --> 00:27:33,900
+protein مدينة صناعة مجموعات متنكلياتيجية مثلما
+
+373
+00:27:33,900 --> 00:27:36,380
+احنا هذا الكلام صرنا مكررين وإميرين واتكرر في كل
+
+374
+00:27:36,380 --> 00:27:40,070
+بيارة ما يكسي فيروس الـ H و الـ N بروتين موجودين
+
+375
+00:27:40,070 --> 00:27:42,470
+على نفس الـ spike فكده لما قلنا لكوا أن 
+
+376
+00:27:42,470 --> 00:27:46,250
+الإنفلوانزا هي من الأرثوميوكسي فيروس وقلنا لكم 
+
+377
+00:27:46,250 --> 00:27:49,930
+أن الأرثوميوكسي فيروس تتميز بأنه كل مصادر موجودة
+
+378
+00:27:49,930 --> 00:27:53,770
+على نفس الـ spike لكن هنا الاثنين ممكن يكونوا
+
+379
+00:27:53,770 --> 00:27:57,090
+موجودين على نفس الـ spike إذا الـH و الـN موجودين
+
+380
+00:27:57,090 --> 00:28:02,170
+على نفس الـspike  الـ F بروتين هو الـ Fusion بروتين
+
+381
+00:28:02,170 --> 00:28:06,380
+موجودة على نفس الـ spike, both human and animals are
+
+382
+00:28:06,380 --> 00:28:10,760
+infected by parainfluenza viruses but the animal
+
+383
+00:28:10,760 --> 00:28:14,480
+strain do not infect human يعني ما فيش cross خلّيني
+
+384
+00:28:14,480 --> 00:28:17,440
+نقول ال barrier بين الإنسان و الحيوان في هذا
+
+385
+00:28:17,440 --> 00:28:20,920
+الحالة موجود ما فيش crossing مش زي ال influenza
+
+386
+00:28:20,920 --> 00:28:26,220
+الطيار ممكن يصيب الخنزير و ال human تصيب الخنزير
+
+387
+00:28:26,220 --> 00:28:30,080
+وبتالي بيصير فينا تبادل لأ هنا في عندي انفصال تمام
+
+388
+00:28:32,070 --> 00:28:35,290
+There are four types و احنا قلنا ان ال
+
+389
+00:28:35,290 --> 00:28:38,790
+parainfluenza من one to four في التصنيف تبعنا
+
+390
+00:28:38,790 --> 00:28:43,790
+which are distinguished by antigenicity يعني من
+
+391
+00:28:43,790 --> 00:28:46,710
+خلال الانتجينيات تبعاتهم, cytopathic effect and
+
+392
+00:28:46,710 --> 00:28:52,230
+pathogenicity واضح انه ليس فقط الاختلاف
+
+393
+00:28:52,230 --> 00:28:56,130
+بالانتجينيات وانما ايضا بقدرتهم على احداث
+
+394
+00:28:56,130 --> 00:29:00,250
+cytopathic effect و بالأمراض اللي هم ايضا بيسببوها
+
+395
+00:29:00,790 --> 00:29:04,290
+Antibody to either the H or the F protein
+
+396
+00:29:04,290 --> 00:29:09,270
+neutralizes infectivity إذن كل مرة بجينا نقول إحنا
+
+397
+00:29:09,270 --> 00:29:13,610
+أن ال Antibody against Hemagglutinin neutralizes
+
+398
+00:29:13,610 --> 00:29:17,830
+infectivity للفيروسات اللي لها Hemagglutinin واللي
+
+399
+00:29:17,830 --> 00:29:22,850
+مالهاش Hemagglutinin كنا نقول أنه Antibody to
+
+400
+00:29:22,850 --> 00:29:29,560
+fusion protein promotes neutralization للإنفكتفية،
+
+401
+00:29:29,560 --> 00:29:34,040
+تمام؟ هنا الـ Antibody لكل من اللي هو الـ
+
+402
+00:29:34,040 --> 00:29:37,460
+Hemagglutinin وله الـ F-Protein، قلنا بيعمل
+
+403
+00:29:37,460 --> 00:29:40,980
+Neutralizes Infectivity، وهذه يعني برضه حاجة
+
+404
+00:29:40,980 --> 00:29:47,610
+مختلفة عن الـ Other Virus. طيب ال Parainfluenza
+
+405
+00:29:47,610 --> 00:29:51,250
+virus are best known as the main cause of croup in
+
+406
+00:29:51,250 --> 00:29:55,690
+children younger than 5 years of age. Croup is
+
+407
+00:29:55,690 --> 00:30:00,990
+characterized by harsh يعني خشن، harsh صعب، cough
+
+408
+00:30:00,990 --> 00:30:03,670
+and hoarseness، hoarseness اللي هي الصوت اللي قلنا
+
+409
+00:30:03,670 --> 00:30:09,210
+عنه هذا الفخم في الكحر. In addition to the croup,
+
+410
+00:30:09,530 --> 00:30:11,930
+these viruses cause a variety of respiratory
+
+411
+00:30:11,930 --> 00:30:25,210
+diseases such as common cold، فرنجايتس،
+
+412
+00:30:25,210 --> 00:30:28,530
+لارنجايتس، أوتايتس ميديا، برونكايتس and نيومونيا
+
+413
+00:30:33,920 --> 00:30:38,400
+طلعوا ال common cold، الفرنجيتس، لارنجيتس، أوتايتس
+
+414
+00:30:38,400 --> 00:30:44,600
+ميديا، برونكايتس and نيمونيا. كلها أمراض للأسف للأسف
+
+415
+00:30:44,600 --> 00:30:50,840
+لما بيروح الطفل على الطبيب يا إما الطبيب نفسه من
+
+416
+00:30:50,840 --> 00:30:55,060
+malpractice من سوء إدارة في العلاج بيعطي
+
+417
+00:30:55,060 --> 00:30:59,660
+antibiotic أو بضغط من الأهالي أنه أعطي antibiotic
+
+418
+00:30:59,660 --> 00:31:04,100
+ضمن من الناس أن ال antibiotic هو الحل السحري لكل
+
+419
+00:31:04,100 --> 00:31:10,450
+هذه الإشكالات للأسف وهذا يعني الكلام اللي احنا
+
+420
+00:31:10,450 --> 00:31:14,010
+بنحكيه لأن هو تأكيد لما نقوله أن نسبة كبيرة من
+
+421
+00:31:14,010 --> 00:31:17,010
+الأمراض اللي بنعطاه الها أنت بتكون أمراض فيروسية
+
+422
+00:31:17,010 --> 00:31:22,890
+وكلّكم يعلم حق المعرفة بإنه الفيروسات لا تستجيب
+
+423
+00:31:22,890 --> 00:31:27,610
+للمضادات الحيوية بأي حال من الأحوال. فش غير فيروس
+
+424
+00:31:27,610 --> 00:31:33,310
+واحد مين بتذكره؟ smallpox. مين بيستجيب له الـ
+
+425
+00:31:33,310 --> 00:31:39,410
+antibiotic؟ بنقول أن ال antibiotic هذا اللي هو
+
+426
+00:31:39,410 --> 00:31:45,530
+Rifamicin كان effective أو لجوا أنه له activity
+
+427
+00:31:45,530 --> 00:31:51,230
+على ال smallpox تمام لكن لم يستخدم في ذاك الوقت
+
+428
+00:31:51,230 --> 00:31:54,950
+فلو صار في المستقبل في smallpox ممكن نستخدم مين؟
+
+429
+00:31:54,950 --> 00:31:57,990
+Rifamicin. هذه المعلومة أعتقد أنه مرت عليكم في ال
+
+430
+00:31:57,990 --> 00:32:03,050
+smallpox. Laboratory diagnoses, most infections are
+
+431
+00:32:03,050 --> 00:32:07,150
+diagnosed clinically. The diagnosis can be made in
+
+432
+00:32:07,150 --> 00:32:10,010
+the laboratory either by isolating the virus in
+
+433
+00:32:10,010 --> 00:32:14,370
+cell culture or by observing a fourfold or greater
+
+434
+00:32:14,370 --> 00:32:18,010
+rise in antibody titers. إذن هي نفس الفكرة في موضوع
+
+435
+00:32:18,010 --> 00:32:21,930
+الارتفاع في تركيز الانتيبادي. Treatment and
+
+436
+00:32:21,930 --> 00:32:26,770
+prevention. There is neither antiviral therapy nor a
+
+437
+00:32:26,770 --> 00:32:30,450
+vaccine available لكن غالبا ال disease self
+
+438
+00:32:30,450 --> 00:32:33,970
+-limited بمعنى أنه بياخد فترة لكن فترة طويلة قد
+
+439
+00:32:33,970 --> 00:32:37,710
+تنتقل أسبوعين أو أكثر بعد ذلك بيبدأ اللي هو الطفل
+
+440
+00:32:37,710 --> 00:32:40,250
+في ال recovery من ال croup اللي جونا عنه ال
+
+441
+00:32:40,250 --> 00:32:44,430
+hoarseness و ال harsh cough اللي وصفنا قبل قليل
+
+442
+00:32:44,430 --> 00:32:52,590
+نأتي للفيروس صاحب التاج اللي هو coronavirus. طبعا
+
+443
+00:32:52,590 --> 00:32:55,910
+كورونا فيروس كده المرة كانت شهرته فقط أن هو أحد
+
+444
+00:32:55,910 --> 00:33:01,790
+المسببات اللي هو ال common cold لكن اشتهر بزيادة
+
+445
+00:33:01,790 --> 00:33:07,990
+لما اكتشفنا أن هو برضه بيسبب ال SARS وصار له اسم
+
+446
+00:33:07,990 --> 00:33:13,660
+ذائع الصيت في الشرق الأوسط لما ارتبط اسم الـ Middle
+
+447
+00:33:13,660 --> 00:33:19,360
+East Respiratory Syndrome Coronavirus اللي هو لحد
+
+448
+00:33:19,360 --> 00:33:24,760
+الآن موجود في مناطق الخليج العربي ويعني يحدث حالات
+
+449
+00:33:24,760 --> 00:33:28,960
+متفرقة هنا وهناك وهناك أنه تم ربطه مع اللي هو
+
+450
+00:33:28,960 --> 00:33:34,210
+الجمال يعني انتقاله عبر اللي هو الجمال. لم ترتقي ال
+
+451
+00:33:34,210 --> 00:33:37,610
+evidence إلى أن بتكون absolute cause and effect
+
+452
+00:33:37,610 --> 00:33:43,650
+لكن القول الدارج والشائع أن الجمال هي الناقل لهذا
+
+453
+00:33:43,650 --> 00:33:44,470
+الفيروس
+
+454
+00:33:47,580 --> 00:33:50,620
+Coronaviruses are important cause of common cold,
+
+455
+00:33:50,740 --> 00:33:56,420
+probably second only to rhinovirus in frequency،
+
+456
+00:33:56,420 --> 00:34:04,220
+في الـ 2002،
+
+457
+00:34:04,220 --> 00:34:08,670
+a new disease, an atypical pneumonia. وكلمة atypical
+
+458
+00:34:08,670 --> 00:34:13,350
+يعني نيمونيا غير نمطية. وكلمة غير نمطية يعني عشان
+
+459
+00:34:13,350 --> 00:34:16,790
+نميز أي نيمونيا تختلف عن ال bacterial pneumonia
+
+460
+00:34:16,790 --> 00:34:20,850
+most commonly caused by a set of caucases
+
+461
+00:34:20,850 --> 00:34:24,890
+النيمونيا بيسموها atypical pneumonia. كلمة atypical
+
+462
+00:34:24,890 --> 00:34:29,490
+pneumonia تعني غير نمطية. غير نمطية في بكتيريا ال
+
+463
+00:34:29,490 --> 00:34:32,570
+micro plasma بتسبب atypical pneumonia. يعني في other
+
+464
+00:34:32,570 --> 00:34:36,860
+causes of atypical pneumonia. هذه الاتميكال نيومونيا
+
+465
+00:34:36,860 --> 00:34:41,000
+سميناها SARS اللي يقول عنها Severe Acute
+
+466
+00:34:41,000 --> 00:34:46,020
+Respiratory Syndrome. الكورونا
+
+467
+00:34:46,020 --> 00:34:49,200
+فايروسز have an RNA segment, single-stranded positive
+
+468
+00:34:49,200 --> 00:34:54,220
+polarity RNA جينوم اللي هنتكلم عنه الآن عن
+
+469
+00:34:54,220 --> 00:34:59,410
+positive polarity مش negative polarity. Helical
+
+470
+00:34:59,410 --> 00:35:02,770
+Nucleocapsid. هم فيروسات محلية مع نوكليوكبسيد
+
+471
+00:35:02,770 --> 00:35:06,570
+تختلف الآن عن البراميوكسي فيروسات في ايش؟ في أن
+
+472
+00:35:06,570 --> 00:35:09,770
+بوستف و بولاريته كانوا كلهم نيجاتيف بولاريته
+
+473
+00:35:19,850 --> 00:35:24,690
+لعنة زي ال racket club shape in the form of
+
+474
+00:35:24,690 --> 00:35:28,250
+corona's halos، واحنا قلنا ان الكورونا بتشبه التاج
+
+475
+00:35:28,250 --> 00:35:33,900
+يعني، بتشبه التاج، can be seen. في سؤالتين واحدة
+
+476
+00:35:33,900 --> 00:35:41,160
+بيسموها 229E واحدة بيسموها OC43. ال genome sequence
+
+477
+00:35:41,160 --> 00:35:44,660
+لل coronavirus caused SARS اللي هو coronavirus
+
+478
+00:35:44,660 --> 00:35:48,000
+SARS outbreak is different from the existing human
+
+479
+00:35:48,000 --> 00:35:51,540
+strain اللي هو بسبب الرشح. يعني كان في اختلاف بين
+
+480
+00:35:51,540 --> 00:35:58,180
+التانينو genome typical coronavirus في التصنيف يعني
+
+481
+00:35:58,180 --> 00:36:01,600
+they are coronaviruses لكن ال genome sequence معهم
+
+482
+00:36:01,600 --> 00:36:04,600
+مختلف بمعنى أنه بالفعل فيهم اختلافات في ال
+
+483
+00:36:04,600 --> 00:36:07,000
+characteristics لهذين الفيروسين
+
+484
+00:36:18,850 --> 00:36:21,030
+Coronaviruses are transmitted by the respiratory
+
+485
+00:36:21,030 --> 00:36:25,090
+aerosols اللي برضه بالرذاب، لاحظوا لحد الآن كل
+
+486
+00:36:25,090 --> 00:36:28,710
+مجموعة من ال RNA enveloped viruses are transmitted
+
+487
+00:36:28,710 --> 00:36:32,930
+في جنها via respiratory aerosols. Infection occurs
+
+488
+00:36:32,930 --> 00:36:36,490
+worldwide and can .. الآن أنا بتكلمش عن ال stars،
+
+489
+00:36:36,490 --> 00:36:38,790
+بتكلم عن ال coronavirus بشكل عام
+
+490
+00:36:42,660 --> 00:36:47,140
+أكثر من خمسين بالمائة من الأطفال أكثر من خمسين
+
+491
+00:36:47,140 --> 00:36:48,420
+بالمائة من الأطفال أكثر من خمسين بالمائة من
+
+492
+00:36:48,420 --> 00:36:49,040
+الأطفال أكثر من خمسين بالمائة من الأطفال أكثر من
+
+493
+00:36:49,040 --> 00:36:49,180
+خمسين بالمائة من الأطفال أكثر من خمسين بالمائة من
+
+494
+00:36:49,180 --> 00:36:50,520
+الأطفال أكثر من خمسين بالمائة من الأطفال أكثر من
+
+495
+00:36:50,520 --> 00:36:52,380
+خمسين بالمائة من الأطفال أكثر من خمسين بالمائة من
+
+496
+00:36:52,380 --> 00:36:56,100
+الأطفال أكثر من خمسين بالمائة من الأطفال أكثر من
+
+497
+00:36:56,100 --> 00:37:03,380
+خمسين بالمائة من الأطفال أكثر من خمسين بالمائة من
+
+498
+00:37:03,380 --> 00:37:05,860
+الأطفال أكثر من خمسين. لسه ما ننسى اللي بحاجتنا عشان
+
+499
+00:37:05,860 --> 00:37:08,920
+ننساه لما قلنا قبل قليل ال respiratory syncytial
+
+500
+00:37:08,920 --> 00:37:14,420
+virus بيختلف عن باقي الفيروسات بإنه كل فصل شتاء 
+
+501
+00:37:14,420 --> 00:37:20,340
+بينتشر بس هاله كل سنتين إلى ثلاث سنوات سارس أصبح
+
+502
+00:37:20,340 --> 00:37:26,160
+في مصر في نوفمبر 2002 وانتقل 
+
+503
+00:37:26,160 --> 00:37:30,020
+إلى بلدان أخرى في برضه منطقة جنوب شرق آسيا
+
+504
+00:37:53,840 --> 00:37:57,040
+والمرة الجاية إن شاء الله بنكمل الـ transmission و
+
+505
+00:37:57,040 --> 00:37:57,600
+الـ Epidemiology 
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/sduOU8FVa0c_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/sduOU8FVa0c_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..bbcf978bf8b61f673d82b9ccead1578449567cfa
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/sduOU8FVa0c_raw.srt
@@ -0,0 +1,2020 @@
+1
+00:00:21,140 --> 00:00:24,620
+بسم الله الرحمن الرحيم نكمل إن شاء الله ما بدأنا
+
+2
+00:00:24,620 --> 00:00:28,940
+المحاضرات السابقة في ال RNA envelope viruses كنا
+
+3
+00:00:28,940 --> 00:00:32,480
+قد وصلنا إلى ال mumps virus وشرحنا لزي كبير منه
+
+4
+00:00:32,480 --> 00:00:37,300
+لابعث إنه نعمل quick revision ل ال mumps virus كنا
+
+5
+00:00:37,300 --> 00:00:41,000
+هو typically بارا مايوكسي فيروس من ناحية المادة
+
+6
+00:00:41,000 --> 00:00:44,760
+الوراثية ومن ناحية حتى كمان ال .. ال .. ال
+
+7
+00:00:44,760 --> 00:00:49,090
+symmetry بتاعة الكبسيد ونوجود ال envelopeخلّامنا
+
+8
+00:00:49,090 --> 00:00:53,770
+عن أنه بيحتوي على two spikes واحد منهم بيحتوي على
+
+9
+00:00:53,770 --> 00:00:57,570
+كل من الـ Neuraminidase و الـ Hemagglutinin
+
+10
+00:00:57,570 --> 00:01:00,230
+والتاني بيحتوي على ال fusion protein مع
+
+11
+00:01:00,230 --> 00:01:04,170
+الهيموليسين يعني عندنا أربع خصائص في هذا ال virus
+
+12
+00:01:04,170 --> 00:01:07,310
+بالإضافة إلى soluble antigen هذا ال soluble
+
+13
+00:01:07,310 --> 00:01:10,570
+antigen تم توظيفه أو استخدامه في عملية ال
+
+14
+00:01:10,570 --> 00:01:12,550
+diagnosis لهذا ال virus
+
+15
+00:01:15,380 --> 00:01:18,520
+واتفقنا إنه بينتقل عبر ال respiratory droplets وإن
+
+16
+00:01:18,520 --> 00:01:22,640
+نسبة كبيرة قد تصل إلى 30% من الأطفال المصابين لا
+
+17
+00:01:22,640 --> 00:01:26,240
+يظهر عليهم معناه سمينها subclinical or inapparent
+
+18
+00:01:26,240 --> 00:01:30,160
+infection ويعادل حالة انخفاض انخفاض كبير جدا في
+
+19
+00:01:30,160 --> 00:01:32,920
+الولايات المتحدة وفيه معظم الدول الأخرى التي
+
+20
+00:01:32,920 --> 00:01:38,750
+تتعامل مع ال vaccinationبجدية كان فيه رقم لا لا
+
+21
+00:01:38,750 --> 00:01:42,470
+يزيد عن ال ال ال الف يعني تت ستمية و تلاتة و
+
+22
+00:01:42,470 --> 00:01:45,470
+تمانين حالة سنة الف وتسعمائة و سبعة و تسعين
+
+23
+00:01:45,470 --> 00:01:48,810
+وبالتأكيد في السنوات اللاحقة قل هذا الرقم
+
+24
+00:01:51,070 --> 00:01:54,550
+أتكلمنا أيضًا إنه الإصابة بيه سواء كان unilateral
+
+25
+00:01:54,550 --> 00:01:58,690
+أو bilateral بال .. بالممص بتوفر long life،
+
+26
+00:01:58,690 --> 00:02:01,710
+immunity وبتالي كان هذا سر نجاح اللي وضبنا ال
+
+27
+00:02:01,710 --> 00:02:05,410
+vaccination اللي استخدمنا أو وضفنا لمنع هذا المرض
+
+28
+00:02:06,980 --> 00:02:09,320
+اتكلمنا عن بعض ال complications من ضمن ال
+
+29
+00:02:09,320 --> 00:02:12,360
+complications كنا فيه حاجتين اسمها Orchitis اللي
+
+30
+00:02:12,360 --> 00:02:15,560
+هي التيابة الخصية و حاجة اسمها meningitis و
+
+31
+00:02:15,560 --> 00:02:19,940
+اتعلمنا ان ال ال mum's virus هو واحد من ثلاثة
+
+32
+00:02:19,940 --> 00:02:23,380
+مشهورين جدا في إحداث ال viral meningitis اللي هم
+
+33
+00:02:23,380 --> 00:02:27,380
+الكوكساكي فيروس و ال eco virus بالاضافة ال mum's
+
+34
+00:02:27,380 --> 00:02:32,890
+virusفي ال lab diagnosis جينا الاتفاق كان على ان
+
+35
+00:02:32,890 --> 00:02:36,470
+ال clinical diagnosis هو الأساس لكن مافيش حسمة
+
+36
+00:02:36,470 --> 00:02:40,950
+clinical diagnosis و نقطة و أول سطر لأ لازم يكون
+
+37
+00:02:40,950 --> 00:02:45,070
+في حسمة laboratory confirmed diagnosis و غالبا في
+
+38
+00:02:45,070 --> 00:02:49,050
+الأوبئة كما ذكرنا سابقاإنه أول حالات قد يتم
+
+39
+00:02:49,050 --> 00:02:52,910
+التعامل معها مخبريا حتى نتأكد من إيه من الحالة ثم
+
+40
+00:02:52,910 --> 00:02:56,710
+بعد ذلك يتم وضع ما يسمى بال case description أو
+
+41
+00:02:56,710 --> 00:03:00,710
+وصف له الحالة وبيتم تشخيص المرض بعد ذلك هو بشكل
+
+42
+00:03:00,710 --> 00:03:06,010
+سريري بشكل أعراض أو signs and symptoms الكلام عن
+
+43
+00:03:06,010 --> 00:03:10,670
+حاجة غريبة أيضا في يد الفيروس هو ال skin testوقلنا
+
+44
+00:03:10,670 --> 00:03:14,470
+لكم ال skin test لم يقعد يستخدم لتشخيص المرض وانما
+
+45
+00:03:14,470 --> 00:03:18,770
+يستخدم لغرض اخر ما هو هذا الغرض هو to evaluate the
+
+46
+00:03:18,770 --> 00:03:23,410
+cell mediated immunity of people يعني بنقيس مدى
+
+47
+00:03:23,410 --> 00:03:26,690
+فعالية ال cell mediated immunity في هؤلاء الأشخاص
+
+48
+00:03:26,690 --> 00:03:33,090
+من خلال ال moms skin testبالنسبة للعلاج ذكرنا انه
+
+49
+00:03:33,090 --> 00:03:38,890
+مافي علاج لهذا الفيروس و ال prevention بتلخص
+
+50
+00:03:38,890 --> 00:03:43,390
+بالتأكيد بعملية اللي هو ال vaccination و باستخدام
+
+51
+00:03:43,390 --> 00:03:47,730
+ال live attenuated vaccineتو immunization جرعتين
+
+52
+00:03:47,730 --> 00:03:51,590
+الجرعة الأولى على الشهر الخامس عشر والجرعة الثانية
+
+53
+00:03:51,590 --> 00:03:55,930
+بعد أربع إلى ست سنوات وتسمى الجرعة الثانية booster
+
+54
+00:03:55,930 --> 00:03:59,730
+dose وقلنا إن هذا ال vaccine أيضا هو واحد من ثلاثة
+
+55
+00:03:59,730 --> 00:04:03,410
+مشتركين مع مجتمعين مع بعض اللي هم ال missiles وال
+
+56
+00:04:03,410 --> 00:04:04,730
+moms والربل
+
+57
+00:04:06,760 --> 00:04:11,220
+و بما انه vaccine life attenuated القاعدة العامة
+
+58
+00:04:11,220 --> 00:04:14,460
+it should not be given to immunocompromised
+
+59
+00:04:14,460 --> 00:04:18,380
+children or pregnant women للأسف ان ال
+
+60
+00:04:18,380 --> 00:04:21,240
+immunoglobulin اللي هي ال antibodies اللي هي ال
+
+61
+00:04:21,240 --> 00:04:25,660
+passive immunity ليس لها فائدة في حال حدوث
+
+62
+00:04:25,660 --> 00:04:30,280
+orchitis عند الذكور مايلها أي قيمة و أي فائدة
+
+63
+00:04:32,780 --> 00:04:35,760
+الفيروس الآخر اللي هو ال respiratory syncytial
+
+64
+00:04:35,760 --> 00:04:39,800
+virus هذا الفيروس على النقيض من اللي جابله اللي
+
+65
+00:04:39,800 --> 00:04:41,680
+جابله احتوى على الأربع خصائص فاكرهم الخصائص
+
+66
+00:04:41,680 --> 00:04:46,040
+الأربعة؟ Hemagglutinin, neuroamylidase, fusion
+
+67
+00:04:46,040 --> 00:04:49,640
+protein و ال hemolytic activity صح؟ هذا لا يحتوي
+
+68
+00:04:49,640 --> 00:04:54,090
+إلا على ال fusion proteinIt is noted for its
+
+69
+00:04:54,090 --> 00:04:57,730
+ability to form multinucleated giant cell، هذه
+
+70
+00:04:57,730 --> 00:05:00,970
+المعلومة أصلا موجودة في كل الفيروسات اللي تحت هذه
+
+71
+00:05:00,970 --> 00:05:05,750
+المجموعة، لكن هذا أخد الإسم syncytia هي ال
+
+72
+00:05:05,750 --> 00:05:08,430
+multinucleated giant cell فسميها respiratory
+
+73
+00:05:08,430 --> 00:05:09,890
+syncytial virus
+
+74
+00:05:13,420 --> 00:05:17,340
+الفيروس بيسبب بعض حالات من النمونيا و
+
+75
+00:05:17,340 --> 00:05:21,020
+البرونكولايتس أنا بدأ أذكركم بس في شغلة مهمة أكمل
+
+76
+00:05:21,020 --> 00:05:24,080
+الفيروس لحد الآن عرفته بيسببه ال common cold ال
+
+77
+00:05:24,080 --> 00:05:29,620
+common cold اللي هو روسيا نسمع واحد
+
+78
+00:05:43,420 --> 00:05:46,980
+الرابع هو الـ Respiratory syncytial virus هيالان
+
+79
+00:05:46,980 --> 00:05:49,700
+أربع فيروسات بسبب common cold
+
+80
+00:05:52,060 --> 00:05:55,680
+It is also an important cause of otitis media يعني
+
+81
+00:05:55,680 --> 00:05:58,800
+التهاب الأذن وسط أيضًا ممكن يسببه بعض الفيروسات
+
+82
+00:05:58,800 --> 00:06:04,200
+مثل هذا الفيروس كمان بيعمل نيومونيا خاصة في الكبار
+
+83
+00:06:04,200 --> 00:06:08,940
+السن أو مما لديهم أمراض cardiopulmonary disease
+
+84
+00:06:08,940 --> 00:06:13,420
+يعني عندهم مشكلة في القلب وفي الرئتين زي chronic
+
+85
+00:06:13,420 --> 00:06:18,220
+diseases في ال lungsمن الخصائص اللي عامة يلو ان هو
+
+86
+00:06:18,220 --> 00:06:22,380
+ده الفيروس زي و زي اي other paramoxivirus من ناحية
+
+87
+00:06:22,380 --> 00:06:25,500
+ايش؟ من ناحية المادة الوراثية المادة الوراثية ايش
+
+88
+00:06:25,500 --> 00:06:32,040
+محتوية؟ محتوية على single strand من negative sense
+
+89
+00:06:32,040 --> 00:06:38,950
+RNA الكبسيد helicalو Enveloped تمام يبقى هو
+
+90
+00:06:38,950 --> 00:06:43,190
+typical بارا مايوكسي فيروس من هذه الناحية وبيحتوي
+
+91
+00:06:43,190 --> 00:06:47,310
+على RNA dependent RNA بوليماريزو بتالي الجينوم
+
+92
+00:06:47,310 --> 00:06:52,450
+تبعه not infectious none infectious جينوم وقلنا
+
+93
+00:06:52,450 --> 00:06:56,270
+لكم بيحتوي فقط على اللي هو ال fusion protein ولا
+
+94
+00:06:56,270 --> 00:06:58,490
+يحتوي على ال hemagglutinin ولا يحتوي على ال
+
+95
+00:06:58,490 --> 00:07:02,730
+neuroaminidase وقلنا لكم مشهور أيضا بأنه بيكون
+
+96
+00:07:02,730 --> 00:07:07,700
+multi nucleated giant cellلسنوات عديدة كان
+
+97
+00:07:07,700 --> 00:07:11,400
+الاعتقاد السائد ان هذا الفيروس يحتوي فقط على one
+
+98
+00:07:11,400 --> 00:07:17,020
+strain مؤخرا تم اكتشاف انه بيحتوي على two strains
+
+99
+00:07:17,020 --> 00:07:22,260
+سموهم subgroup A و subgroup B وهذا الاكتشاف كان من
+
+100
+00:07:22,260 --> 00:07:25,760
+خلال انه وضفنا different monoclonal antibodies
+
+101
+00:07:25,760 --> 00:07:29,080
+لعبان من الفئة الملاجئة انه في بعض الاختلافات في
+
+102
+00:07:29,080 --> 00:07:34,500
+سلالتين مش سلالة واحدةعلى الرغم من أنه سلالتين و
+
+103
+00:07:34,500 --> 00:07:37,520
+سلالة واحدة مش حاجة كبيرة و ده لأ يعني ممكن نعملهم
+
+104
+00:07:37,520 --> 00:07:41,440
+vaccine لكن للأسف مافيش vaccine لهذا ال virus
+
+105
+00:07:41,440 --> 00:07:46,740
+بالعكس لما حاولنا نعمل vaccine الناس اللي طعمناهم
+
+106
+00:07:46,740 --> 00:07:50,100
+صارت severity of the disease أسوأ من اللي ما
+
+107
+00:07:50,100 --> 00:07:56,140
+طعمناهمشو هنشرحلكم كل الكلام الآن بشكل واضح عشان
+
+108
+00:07:56,140 --> 00:07:59,820
+نفهمه و نعرف انه في بعض الأحيان ال
+
+109
+00:07:59,820 --> 00:08:05,480
+immunopathogenesis بيكون أخطر من ال virus itself و
+
+110
+00:08:05,480 --> 00:08:09,580
+هذا عبارة عن immunopathogenesis بيكون أسمع علوة
+
+111
+00:08:09,580 --> 00:08:12,700
+مني الآن كمان إضافية عشان نقدر نوصل الرسالة تبعتنا
+
+112
+00:08:12,700 --> 00:08:19,340
+ان هذا ال virus تقريبا بيصيب كل البشرفي عمر تلات
+
+113
+00:08:19,340 --> 00:08:23,040
+سنوات يعني لما احنا بنبلغ عمر تلات سنوات شبه مؤكد
+
+114
+00:08:23,040 --> 00:08:26,720
+ان احنا نكون انصبنا بهذا ال virus على الأقل مرة
+
+115
+00:08:26,720 --> 00:08:34,700
+واحد يبقى واسع الانتشار ويله ميزة كمان في انتشاره
+
+116
+00:08:34,700 --> 00:08:39,020
+انتشاره غريب بيروسات الرشحة الأخرى اللي ذكرناهم
+
+117
+00:08:39,020 --> 00:08:46,260
+تمام ميزتهم انهم بدخلوش كلشتاء كل winter يعني كل
+
+118
+00:08:46,260 --> 00:08:51,760
+فصل شتاء على ال .. ال .. ال outbreaks كل سنتين أو
+
+119
+00:08:51,760 --> 00:08:54,420
+تلاتة بدخلوا في ال cycle يعني الواحد اللي عمل
+
+120
+00:08:54,420 --> 00:08:57,680
+السنة هذه برتاحه سنتين تلاتة وبعدين بيعمل cycle
+
+121
+00:08:57,680 --> 00:09:04,300
+بعد سنتين تلاتة هذا ال virus لازم كل شتاء كل فصل
+
+122
+00:09:04,300 --> 00:09:11,890
+شتاء بيعمل infection إذا هو common بصيبنسبة كبيرة
+
+123
+00:09:11,890 --> 00:09:18,790
+قد تصل إلى 100% من الأطفال by the age of 3 طيب وين
+
+124
+00:09:18,790 --> 00:09:21,890
+خطورة .. وين خطورة الفيروس و ال
+
+125
+00:09:21,890 --> 00:09:25,790
+immunopathogenesis؟ الآن بما أن احنا كلنا انصبنا
+
+126
+00:09:25,790 --> 00:09:29,770
+يبقى أبناءكم برضه شمالهم هيكون لأ هيكون عندهم
+
+127
+00:09:29,770 --> 00:09:33,790
+antibody لأن انتوا عندكوا تكون antibodies من
+
+128
+00:09:33,790 --> 00:09:36,710
+الإثارة الأولانية الأسئلة اللي وصبتوا فيها فينكوا
+
+129
+00:09:36,710 --> 00:09:42,050
+antibodies فتنقلوها إلى أطفالكمالان ال antibody
+
+130
+00:09:42,050 --> 00:09:45,010
+المفروض انه حاجة كويسة بدلها بدلها حاجة كويسة يعني
+
+131
+00:09:45,010 --> 00:09:48,750
+المفروض نكون فارحين بإنه صار فيها انها antibody
+
+132
+00:09:48,750 --> 00:09:54,970
+عند الطفل لان لو ال virus دخل ال lungs تبعت الطفل
+
+133
+00:09:54,970 --> 00:10:01,150
+ال antibodies بتحاول يتهاجم من ال virus فبيتكون
+
+134
+00:10:01,150 --> 00:10:05,710
+انتج انتج antibody complex للأسف هوين بتكون في ال
+
+135
+00:10:05,710 --> 00:10:09,470
+lungsوبصير في activation لل complement وبصير في
+
+136
+00:10:09,470 --> 00:10:16,210
+attack لل lung cells أي خلية بتموت هو تعبير وإشارة
+
+137
+00:10:16,210 --> 00:10:18,750
+للخلايا الأخرى اللي لازم منها بيجيوا يعرفوا إيش
+
+138
+00:10:18,750 --> 00:10:22,130
+السبب، إذا كان المشكلة بيحلوها، فبيتكون برضه
+
+139
+00:10:22,130 --> 00:10:26,590
+immune storm في منطقة ال lungsوبالتالي ال severity
+
+140
+00:10:26,590 --> 00:10:31,090
+of disease بتكون أعلي وهذا ما حدث عندما قمنا
+
+141
+00:10:31,090 --> 00:10:35,810
+بإعطاء الأطفال vaccine عطيناهم vaccine بفيروس ميت
+
+142
+00:10:35,810 --> 00:10:39,350
+فكوّنوا أجسام مضادة لأن لما اتعرض هو ال infection
+
+143
+00:10:39,350 --> 00:10:44,650
+كان عنده كام كبير من الأجسام المضادة تفاعلت كمان
+
+144
+00:10:44,650 --> 00:10:48,090
+مرة مع الفيروس وبالتالي أحدثت ضرر بشكل أكبر
+
+145
+00:10:48,090 --> 00:10:53,510
+وبالتالي ال vaccine الآن لا يستخدم مع هذه ال
+
+146
+00:10:53,510 --> 00:10:57,170
+disease هذا واحدهذا السبب ان احنا ماعملناش
+
+147
+00:10:57,170 --> 00:11:00,510
+vaccination مش لأنه two strains لأ مافي مشكلة ان
+
+148
+00:11:00,510 --> 00:11:03,670
+نكون two strains أساسا ماهي ال polio ثلاثة strains
+
+149
+00:11:03,670 --> 00:11:10,890
+ومع ذلك شغالين فيه السبب التاني غير اللي ذكرناها
+
+150
+00:11:10,890 --> 00:11:15,490
+هذا انه بيعمل immune complexes ان في عندي مشكلة
+
+151
+00:11:15,490 --> 00:11:21,510
+حقيقية ان الجهاز المناع ردت فعله ضد هذا الفيروس
+
+152
+00:11:21,510 --> 00:11:26,650
+incompleteكيف أعرف إنه incomplete؟ أقول لك الشخص
+
+153
+00:11:26,650 --> 00:11:31,390
+الواحد قد يصاب بهذا الفيروس عدة مرات خلال فترة
+
+154
+00:11:31,390 --> 00:11:35,950
+الطفولة يعني مافيش مناعة طوال الأمد، مناعة إما
+
+155
+00:11:35,950 --> 00:11:40,570
+قصيرة أو غير مكتملة وبتالي الفاكسين لو احنا نجحنا
+
+156
+00:11:40,570 --> 00:11:43,850
+بإنه ماكانش فيه immunopathogenesis واضح إن
+
+157
+00:11:43,850 --> 00:11:48,770
+الفاكسين مابيعطيش complete immunity ضد هذا الفيروس
+
+158
+00:11:48,950 --> 00:11:52,710
+إذن هذا الفيروس إله خلّينا نقول مزايا مختلفة عن ال
+
+159
+00:11:52,710 --> 00:11:57,230
+other viruses انتشاره الواسع 100% من الناس اللي
+
+160
+00:11:57,230 --> 00:12:00,030
+أتصاب فيه رقم 2 مالوش vaccine وعرفنا ليش مالوش
+
+161
+00:12:00,030 --> 00:12:03,770
+vaccine وعرفنا إن ال pathogenesis تبعته مركز على
+
+162
+00:12:03,770 --> 00:12:08,270
+ال immunopathogenesis أكتر ما هو مركز على ال virus
+
+163
+00:12:08,270 --> 00:12:09,090
+itself
+
+164
+00:12:12,710 --> 00:12:15,350
+الجولة الأخيرة في اللوحة هذه Antibody against the
+
+165
+00:12:15,350 --> 00:12:19,450
+fusion protein neutralizes infectivity ايش يعني
+
+166
+00:12:19,450 --> 00:12:23,470
+infectivity؟ قدرة الفيروس انه يعمل infection ل ال
+
+167
+00:12:23,470 --> 00:12:28,410
+other cells هذا برضه ميزة جيدة لكن للأسف كمان مرة
+
+168
+00:12:28,410 --> 00:12:34,700
+هو بيرتباطه مع ال antigen مع ال fusion proteinهو
+
+169
+00:12:34,700 --> 00:12:38,240
+عبارة عن immune complexes وبالتالي هو بيمنع
+
+170
+00:12:38,240 --> 00:12:41,440
+الفيروس من أنه يصيب يصيب خلايا ال lungs لكن بيعمل
+
+171
+00:12:41,440 --> 00:12:44,340
+activation لمن؟ لل complement وبالتالي بدمر خلايا
+
+172
+00:12:44,340 --> 00:12:49,020
+ال lungs ففي الحالتين الفيروس دخل بدمر ما دخل أيضا
+
+173
+00:12:49,020 --> 00:12:54,620
+بيدمر هذه
+
+174
+00:12:54,620 --> 00:12:58,420
+كلها كلام مكرر من اللي ذكرناها معدى الفقرة الأخيرة
+
+175
+00:12:59,810 --> 00:13:02,770
+الـ RSV اللي هو Respiratory Sensitive Virus also
+
+176
+00:13:02,770 --> 00:13:05,350
+causes outbreaks of respiratory infection in
+
+177
+00:13:05,350 --> 00:13:08,150
+hospitalized infants يعني أطفال مناومين في
+
+178
+00:13:08,150 --> 00:13:12,750
+المشافي، في المستشفيات، بيعمل بينهم تفشيات تخيلوا
+
+179
+00:13:12,750 --> 00:13:17,330
+ال infants، هنعرف كمان شوية إنه ال severity فيهم
+
+180
+00:13:17,330 --> 00:13:21,690
+أعلى من الآخرين، إيش السبب؟ إنه لسه بيحتووا على
+
+181
+00:13:21,690 --> 00:13:24,650
+مين؟ على antibodies من اللي هو ال maternal
+
+182
+00:13:24,650 --> 00:13:29,510
+antibodiesتبتالي إذا كان فيه hospitalized infants
+
+183
+00:13:29,510 --> 00:13:34,630
+وصار outbreak لازم نتخذ كل الإجراءات الملائمة للحد
+
+184
+00:13:34,630 --> 00:13:39,870
+من انتشار العدوى و أهم إجراءين في منع العدوى هم
+
+185
+00:13:39,870 --> 00:13:45,250
+غسل اليدين بالطريقة الصحيحة ولبس اللي هو ال gloves
+
+186
+00:13:45,250 --> 00:13:50,470
+بشكل سليم أيضا كمان مرة لبس ال guanti بشكل سليم مش
+
+187
+00:13:50,470 --> 00:13:53,310
+بجرد نلبس ال guanti و انتهى عن الموضوعوانا ممكن
+
+188
+00:13:53,310 --> 00:13:57,650
+ذكرتلكوا في اكثر من موقف ممكن في مساقات اخرى انه
+
+189
+00:13:57,650 --> 00:14:02,350
+مصطلح ما يسمى بال false sense of security الشعور
+
+190
+00:14:02,350 --> 00:14:10,750
+الكاذب بالامان ووضحتلكوا بمثال سيارة اللي بيقودها
+
+191
+00:14:10,750 --> 00:14:17,830
+شخص تمام وعلى المقود في سكين موجه باتجاه السائق
+
+192
+00:14:17,830 --> 00:14:23,810
+وفي أمام السائق من السيارة من الأمام لغمتمام؟
+
+193
+00:14:23,810 --> 00:14:27,910
+موصول بـ C حديد طويل و في الخلف أيضا لغام مكتبين
+
+194
+00:14:27,910 --> 00:14:31,770
+على السيارة هي السيارة الأأمن في العالمفطبعا البعض
+
+195
+00:14:31,770 --> 00:14:35,970
+بيضحك و بيستهزق بهذا الكريكاتير و بيقول كيف هي
+
+196
+00:14:35,970 --> 00:14:42,430
+سيارة أمن و فيها خنجر او سكين لو ضرب بريك السائق
+
+197
+00:14:42,430 --> 00:14:46,430
+هتغزه في صدره لو اقترب من سيارة أخرى السيخ هيضرب
+
+198
+00:14:46,430 --> 00:14:49,310
+في السيارة و هتنفجر و لو اقتربت في سيارة من الخلف
+
+199
+00:14:49,310 --> 00:14:54,570
+أيضا كذلك الأمر هينفجر، إذا كيف هي أمن سيارة؟شعور
+
+200
+00:14:54,570 --> 00:14:59,590
+السائق باللي انا ذكرته هذا هيجعله ايش معله متيقظ و
+
+201
+00:14:59,590 --> 00:15:03,830
+حذر هينظر الى الخلف و هينظر الامام و لن يسرع بشكل
+
+202
+00:15:03,830 --> 00:15:09,410
+كبير وبتالي بيكون خافة فحذرة فسلم لكن تعالوا
+
+203
+00:15:09,410 --> 00:15:12,890
+تطلعوا على السيارات السيارات الحديثة بقولك ان فيها
+
+204
+00:15:12,890 --> 00:15:18,630
+نظام انضار للاصطدام و فيها airbag و فيها و كده و
+
+205
+00:15:18,630 --> 00:15:23,170
+مع ذلك نسبة الحوادث زادتو نسبة الوفيات من هذه
+
+206
+00:15:23,170 --> 00:15:27,710
+الحوادث زادت، ليش؟ لأنه شعر بإنه فيه أمان، فلما
+
+207
+00:15:27,710 --> 00:15:33,070
+شعر بأمان استهتر وبالتالي أخطأ، الآن هذا ينطق
+
+208
+00:15:33,070 --> 00:15:36,090
+تماما على لبسنا ال gloves في المستشفيات و ال
+
+209
+00:15:36,090 --> 00:15:39,730
+infection controlكتير من الناس اللي نشوفهم في
+
+210
+00:15:39,730 --> 00:15:44,050
+المعامل، لابس gloves و لابس المريول و ماسك الجوال
+
+211
+00:15:44,050 --> 00:15:48,050
+و بعمل نت و بمسك الأقلام تبعته و بكتف فيها و الشنط
+
+212
+00:15:48,050 --> 00:15:52,490
+تبعته و بدور فيها و بمسك المساحة بال gloves و كأنه
+
+213
+00:15:52,490 --> 00:15:57,830
+ايه؟ و كأنه مدام لابس gloves يبقى protected، لأ مش
+
+214
+00:15:57,830 --> 00:16:03,340
+protectedإذا ما إشتغلناش بال gloves صح بنكون مش بس
+
+215
+00:16:03,340 --> 00:16:06,760
+مش protected احنا بننقل العدو ده هأحكيلكوا إيش
+
+216
+00:16:06,760 --> 00:16:12,120
+تجربة أحد الشركات ال ال ال ال ال ال biotech عملت
+
+217
+00:16:12,120 --> 00:16:19,260
+مع الموظفين المحتملين جابونهم كتاب صغير دليل ما هي
+
+218
+00:16:19,260 --> 00:16:22,860
+الأماكن اللي هيروحوا عليها في ال ال ال غرفة
+
+219
+00:16:22,860 --> 00:16:25,820
+الكبيرة الواسعة وإيش يشتغلوا تجارب بسيطة عاملينها
+
+220
+00:16:25,820 --> 00:16:29,850
+تجارب بسيطة زي تجارب كفل معاملبس الفرج إنهم حطولهم
+
+221
+00:16:29,850 --> 00:16:34,750
+على إيد الباب لما دخلوا حطولهم مادة بتنشاف بال
+
+222
+00:16:34,750 --> 00:16:37,650
+ultra fluorescent بتنشاف بال ultra violet light
+
+223
+00:16:37,650 --> 00:16:43,130
+تمام؟ فكل واحد دخل الباب مسك الأكره يبقى مسك معاه
+
+224
+00:16:43,130 --> 00:16:48,160
+أشلان أخد جزء من إيه؟ المادةو بعد أربع ساعات من
+
+225
+00:16:48,160 --> 00:16:54,900
+دخولهم للقاع طفوا ضواء و وقفوا الشغل طفوا الأضواء
+
+226
+00:16:54,900 --> 00:16:58,360
+و شغلوا نوع من ال ultraviolet light غير مؤذى بس
+
+227
+00:16:58,360 --> 00:17:01,840
+بكشف عن الفلوريسين لكم أنت تخيلوا وين لقوا
+
+228
+00:17:01,840 --> 00:17:06,080
+الفلوريسين في شعورهم في جرابينهم في أحدياتهم في
+
+229
+00:17:06,080 --> 00:17:10,960
+ملابسهم الداخلية حتى لقوا موجود الفلوريسين مع أنه
+
+230
+00:17:10,960 --> 00:17:14,960
+مش مالهم كلهم دخلوا لبسوا gloves و لبسوا ياش مرايل
+
+231
+00:17:15,750 --> 00:17:21,130
+الذين أظهروا أقل تلوث في أجسامهم، في البيئة
+
+232
+00:17:21,130 --> 00:17:25,210
+تبعاتهم، هم الذين اختيروا لهذه الوظيفة، يعرفوا
+
+233
+00:17:25,210 --> 00:17:28,470
+يعني انه لابسين ال gloves ليش لابسين ال gloves؟ To
+
+234
+00:17:28,470 --> 00:17:31,110
+protect themselves, to protect the environment, to
+
+235
+00:17:31,110 --> 00:17:37,040
+protect othersهذا هو الغرض وبالتالي ال .. ال .. ال
+
+236
+00:17:37,040 --> 00:17:40,700
+infection control أحد أساسيته غسل الإيدان بطريقة
+
+237
+00:17:40,700 --> 00:17:44,080
+صحيحة والتانية اللي هي بنا لبس ال gloves بين أو ال
+
+238
+00:17:44,080 --> 00:17:46,880
+changing ل ال gloves بين patient و patient أخر
+
+239
+00:17:53,650 --> 00:17:57,610
+برضه تقريبا في هذه اللوحة كل ما ذكر فيها ذكرناها
+
+240
+00:17:57,610 --> 00:18:02,250
+إلا الجملة الأخيرة وهي لماذا تزداد مناعتنا ضد هذا
+
+241
+00:18:02,250 --> 00:18:05,820
+الفيروس عندما نكبر؟غالبا جهاز الملاعب التلقائية
+
+242
+00:18:05,820 --> 00:18:11,120
+بتحسن قدرته على إنتاج اللي هو ال IGA وال IGA هو
+
+243
+00:18:11,120 --> 00:18:14,860
+غير عن ال IGG ال IGA لا ينشط بناء ال complement
+
+244
+00:18:14,860 --> 00:18:18,780
+بنشطش ال complement مين بنشط ال complement ال IGG
+
+245
+00:18:18,780 --> 00:18:22,520
+و ال IGM كلاهما بنشطوا ال complement هذا ما بنشطش
+
+246
+00:18:22,520 --> 00:18:27,300
+وبتالي وين موجود؟ موجود في ال secretory او في ال
+
+247
+00:18:27,300 --> 00:18:30,240
+secretions اللي من ضمنها ال mucus وبتالي هو بيعمل
+
+248
+00:18:30,240 --> 00:18:35,760
+protection من الفيروسبطريقة لا تؤذي ايضا او لا
+
+249
+00:18:35,760 --> 00:18:41,900
+تنشط جهاز المناعة In
+
+250
+00:18:41,900 --> 00:18:45,540
+infants, RSV is an important cause of lower
+
+251
+00:18:45,540 --> 00:18:48,700
+respiratory tract disease such as broncholitis and
+
+252
+00:18:48,700 --> 00:18:51,940
+pneumonia وممكن في الـ young children يعني الـ
+
+253
+00:18:51,940 --> 00:18:55,340
+otitis media كما ذكرنا، في ال children and young
+
+254
+00:18:55,340 --> 00:18:56,340
+healthy adults
+
+255
+00:19:00,970 --> 00:19:05,670
+الناس عندهم مناعة منخفض ولكن ناس عاديين RSV causes
+
+256
+00:19:05,670 --> 00:19:08,930
+the respiratory tract infections such as common
+
+257
+00:19:08,930 --> 00:19:15,250
+cold and bronchitisفي الكبار السن اللي هم أكبر من
+
+258
+00:19:15,250 --> 00:19:18,850
+65 سنة and in adults with chronic cardiopulmonary
+
+259
+00:19:18,850 --> 00:19:21,510
+diseases يعني هو بسبب مش cardiopulmonary disease
+
+260
+00:19:21,510 --> 00:19:24,470
+لو هو بسبب مرض في اللي عندهم cardiopulmonary
+
+261
+00:19:24,470 --> 00:19:28,710
+disease RSV causes severe lower respiratory tract
+
+262
+00:19:28,710 --> 00:19:32,690
+disease including pneumoniaلأ لأ لأ إذا بتلاحظوا
+
+263
+00:19:32,690 --> 00:19:36,750
+معظم المحاضرة بنركز على مين هنا على ال pneumonia
+
+264
+00:19:36,750 --> 00:19:40,970
+الناجمة عن هذا ال virus لأن ال pneumonia is more
+
+265
+00:19:40,970 --> 00:19:43,850
+dangerous than other respiratory tract infection
+
+266
+00:19:43,850 --> 00:19:47,230
+من
+
+267
+00:19:47,230 --> 00:19:50,970
+الفحوصات المستخدمة لل diagnosis طبعا شفتوا ال
+
+268
+00:19:50,970 --> 00:19:55,030
+missiles كان لها أعراض واضحة ال mum's كان له أعراض
+
+269
+00:19:55,030 --> 00:19:58,930
+واضحة لكن هذا مالوش أعراض تشترك أعراضه بيه مع
+
+270
+00:19:58,930 --> 00:20:04,380
+ميكروبات أخرىلذا الكلام الواجب علينا انه نتعرف على
+
+271
+00:20:04,380 --> 00:20:08,680
+الفيروس من خلال rapid antigen test بيستخدم ووظف
+
+272
+00:20:08,680 --> 00:20:14,340
+تقنية ال Immuno Assay وبيكشف عن الفيروس في ال
+
+273
+00:20:14,340 --> 00:20:17,100
+respiratory secretions زي ال nasal secretion أو من
+
+274
+00:20:17,100 --> 00:20:20,460
+عينة Sputum ممكن ايضا يتم الكشف عن الفيروس
+
+275
+00:20:20,460 --> 00:20:24,140
+باستخدام immunofluorescence اما من ال Epithelial
+
+276
+00:20:24,140 --> 00:20:27,120
+tissue اللي طالع مع ال Sputum او من خلال ال
+
+277
+00:20:27,120 --> 00:20:32,590
+isolation في cell cultureأهم CPE في الـ Cell
+
+278
+00:20:32,590 --> 00:20:35,550
+Culture بنشوف اللي هو مين؟ الـ Multi-Nucleated
+
+279
+00:20:35,550 --> 00:20:40,590
+Giant Cell أو اللي يكون عنه Synthetic أيضا لا
+
+280
+00:20:40,590 --> 00:20:44,510
+يختلف عن أخوته من الفيروس الأخرى في موضوع الـ
+
+281
+00:20:44,510 --> 00:20:48,150
+Detection للـ Antibody Fourfold Increase، أيش يعني
+
+282
+00:20:48,150 --> 00:20:54,090
+Fourfold؟زيادة تيتر تبع ال antibody باربعة أضعاف
+
+283
+00:20:54,090 --> 00:20:59,150
+بين ال acute sample أو ال specimen و ال
+
+284
+00:20:59,150 --> 00:21:02,570
+convalescent specimen اللي بينهم مجدش من عشرة إلى
+
+285
+00:21:02,570 --> 00:21:06,770
+أربعة عشر يوم ما بين العينة الأولى و الثانية وأيضا
+
+286
+00:21:06,770 --> 00:21:11,010
+نذكر مره أخرى بإنه من يوم من ال zero time اللي
+
+287
+00:21:11,010 --> 00:21:13,130
+احنا خدنا فيه العينة لأربع عشر يوم بيكون المريض
+
+288
+00:21:13,130 --> 00:21:18,150
+اشماله شوفيه فبالتالي الفحص هنا just to confirm
+
+289
+00:21:18,150 --> 00:21:22,560
+the caseهل ترى ال confirmation هذا بيستحق انه نجري
+
+290
+00:21:22,560 --> 00:21:26,380
+الفحص مرتين نعم يستحق عشان نقدر نعرف بالفعل ال
+
+291
+00:21:26,380 --> 00:21:30,080
+exact etiology هل احنا كنا بنعالج في disease صح
+
+292
+00:21:30,080 --> 00:21:35,500
+ولا ممكن يكون other disease واختفى لوحدنا طبعا هذا
+
+293
+00:21:35,500 --> 00:21:39,760
+دخل على الصحة معانا فحص جديد اللي هو اسمه RT-PCR
+
+294
+00:21:39,760 --> 00:21:43,260
+او reverse transcriptase polymerase chain reaction
+
+295
+00:21:43,260 --> 00:21:49,080
+ملان متاح لهذا الفيروسبالنسبة للعلاج لدينا
+
+296
+00:21:49,080 --> 00:21:55,860
+antiviral اسمه ribavirin، ال ribavirin ما بنعطيهوش
+
+297
+00:21:55,860 --> 00:21:59,280
+injection في هذا الحالة، بنعطيه زي بخاخة
+
+298
+00:21:59,280 --> 00:22:05,460
+aerosolized عشان بنرشه عشان يصلوان لل lungsلمن
+
+299
+00:22:05,460 --> 00:22:11,160
+نعطي فقط for severely ill infants يعني الرضا اللي
+
+300
+00:22:11,160 --> 00:22:16,320
+عندهم المرض حاد بشكل كبير جدا اقرأ الجبنة اللي
+
+301
+00:22:16,320 --> 00:22:19,880
+بعديها ايش بتقول but there is uncertainty
+
+302
+00:22:19,880 --> 00:22:24,800
+regarding its effectiveness يعني هناك شكوك حول
+
+303
+00:22:24,800 --> 00:22:29,900
+فعالية هذا ال antiviral drug a combination of
+
+304
+00:22:29,900 --> 00:22:33,670
+ribavirinand hyper immunoglobulin كلمة hyper
+
+305
+00:22:33,670 --> 00:22:36,470
+immunoglobulin اخدناها في ال passive immunity انه
+
+306
+00:22:36,470 --> 00:22:40,650
+solution بيحتوي على تركيز عالي من ايه؟ من ال
+
+307
+00:22:40,650 --> 00:22:45,250
+immunoglobulin against RSV maybe more effective
+
+308
+00:22:45,250 --> 00:22:51,390
+لحظة الجملتين maybe والأولانية أشمالها uncertainty
+
+309
+00:22:51,390 --> 00:22:57,600
+هل هذه لغة تفهمونها أنتم؟يعني لو واحد قد اسألني
+
+310
+00:22:57,600 --> 00:23:02,060
+جالي مين أحسن أخد ال .. ال ribavirin ولا ribavirin
+
+311
+00:23:02,060 --> 00:23:05,660
+and hyper immunoglobulin أنا بصفة microbiologist
+
+312
+00:23:05,660 --> 00:23:10,340
+مابقولكم مش هعرف لكن بصفة طبيب لو أنا ده أكون طبيب
+
+313
+00:23:10,340 --> 00:23:15,900
+لازم أجاوبكم و أعطيكم الخيارات أعطيكم خيارات إذا
+
+314
+00:23:15,900 --> 00:23:18,980
+هذه اللغة المستخدمة هي لغة العلماء لغة العلم
+
+315
+00:23:18,980 --> 00:23:23,750
+والعلماء تختلف عن لغة الخدماتلغة الخدمات غالبا
+
+316
+00:23:23,750 --> 00:23:28,030
+بنحب تكون قطيع بأرقام، مزودة بأرقام، وده أعطي مثال
+
+317
+00:23:28,030 --> 00:23:32,710
+.. مثال صغير على اللغة العلمية من السلف الصالح،
+
+318
+00:23:32,710 --> 00:23:35,650
+أنا لأ .. لأ .. لست متأكد عن من قال هذه العبارة،
+
+319
+00:23:35,650 --> 00:23:40,460
+لكن أظنه الإمام الشافعي رحمه اللهرأي صواب يحتمل
+
+320
+00:23:40,460 --> 00:23:46,960
+الخطأ ورأيك خطأ يحتمل الصواب لحظه هو شبه متأكد من
+
+321
+00:23:46,960 --> 00:23:50,980
+رأيه إلا إنه ترك مجال لل uncertainty لل maybe
+
+322
+00:23:50,980 --> 00:23:57,820
+فاهم؟ ومتأكد أيضا من خطأ الرأي اللي أمامه لكن أيضا
+
+323
+00:23:57,820 --> 00:24:03,400
+ترك مجال إنه ممكن يكون صواب هذه لغة العلم لغة غير
+
+324
+00:24:03,400 --> 00:24:06,760
+قطعية وانا أرجو من حضراتكم إنكم تستوعبوا هذا
+
+325
+00:24:06,760 --> 00:24:10,810
+المصطلح maybeuncertain I'm not sure هذه كلها
+
+326
+00:24:10,810 --> 00:24:14,750
+اللغات اللغة لا تنقص من قدر قائلها شيئا يعني
+
+327
+00:24:14,750 --> 00:24:19,770
+تعلموا أنت قولوا لا أدري لا أعرف ربما غير متأكد
+
+328
+00:24:19,770 --> 00:24:25,490
+هذه هذه المصطلحات بس في الامتحان لا طبعا لست متأكد
+
+329
+00:24:25,490 --> 00:24:30,390
+انا من ان اي دي بدي دقيقةهذا يعتبر خدمات .. يعتبر
+
+330
+00:24:30,390 --> 00:24:34,490
+خدمات .. وصل الصورة أرجو .. أرجو أن اللغة العلمية
+
+331
+00:24:34,490 --> 00:24:38,850
+تسود يعني في مجتمعنا لأنه هي اللغة الكفيلة بتغيير
+
+332
+00:24:38,850 --> 00:24:43,320
+سلوك الناسطيب ال prevention هنقول إنه مافيش
+
+333
+00:24:43,320 --> 00:24:49,120
+vaccine متاح لهذا ال virus و ذكرنا إنه كان في
+
+334
+00:24:49,120 --> 00:24:52,760
+محاولات سابقة باستخدام ال killed vaccine .. ال
+
+335
+00:24:52,760 --> 00:24:58,720
+killed vaccine زادت من سوق حالة المرضى بشكل كبير
+
+336
+00:24:58,720 --> 00:25:03,910
+جدالكن في immunoglobulins زي ما ذكرنا و في منها
+
+337
+00:25:03,910 --> 00:25:08,550
+تحضيرات مختلفة و تعطى يعني كبروفيلاكسز خاصة في ال
+
+338
+00:25:08,550 --> 00:25:11,950
+premature babies وين ال premature babies بيكونوا؟
+
+339
+00:25:12,890 --> 00:25:16,390
+في الحضة أناصحها تذكروا قبل قليل تحدثنا عن
+
+340
+00:25:16,390 --> 00:25:21,330
+outbreaks للإنفان فلما يكونوا premature أساسا
+
+341
+00:25:21,330 --> 00:25:25,530
+تمام؟ Premature عندهم أول حد ملقتهم ضعيفة و عندهم
+
+342
+00:25:25,530 --> 00:25:29,090
+أصلا immunoglobulin maternal antibody وبتالي
+
+343
+00:25:29,090 --> 00:25:33,350
+إمكانية أن تكون ال disease فيهم severe عالية جدا
+
+344
+00:25:33,350 --> 00:25:37,610
+فيمكن اعطاهم في هذه الحالة immunoglobulin
+
+345
+00:25:39,840 --> 00:25:43,940
+hyperimmunoglobulin أيضا بيستخدم كبروفيلاكسس في
+
+346
+00:25:43,940 --> 00:25:46,980
+الانفنس and in children with chronic lung disease
+
+347
+00:25:46,980 --> 00:25:51,420
+نوزوكوميا ال outbreaks could be prevented by hand
+
+348
+00:25:51,420 --> 00:25:57,930
+washing and wearing gloves أو using glovesطبعا
+
+349
+00:25:57,930 --> 00:26:00,870
+بالخطأ مكرر هذا الفيروس اللي انا بتكلم عن ال
+
+350
+00:26:00,870 --> 00:26:05,850
+Parainfluenza viruses ال Parainfluenza مين أخوهم
+
+351
+00:26:05,850 --> 00:26:10,090
+من الفيروسات ال mumps ال mumps و ال Parainfluenza
+
+352
+00:26:10,090 --> 00:26:15,550
+كنا هما التانين تحت عنوان اسمه Paramyocovirus طبعا
+
+353
+00:26:15,550 --> 00:26:19,150
+لسه
+
+354
+00:26:19,150 --> 00:26:20,550
+ذاكرين التصنيفات هذه
+
+355
+00:26:23,340 --> 00:26:28,140
+parainfluenza viruses disease these viruses causes
+
+356
+00:26:28,140 --> 00:26:34,580
+croup croup لسه متأكدا أيضا من المعنى باللغة
+
+357
+00:26:34,580 --> 00:26:40,080
+العربية ولكن هو نوع من الكحة الجافة يعني الجافة
+
+358
+00:26:40,080 --> 00:26:47,040
+تماما ومزعجة جدا لحتى لمستمع الشخص اللي بيسمعها
+
+359
+00:26:47,040 --> 00:26:55,430
+لإن صوت الكحة بيكون بالفعل جاف جدا و للغايةAcute
+
+360
+00:26:55,430 --> 00:26:58,150
+laryngobronchitis، لارينجايتس، برونكولايتس و
+
+361
+00:26:58,150 --> 00:27:03,030
+نيومونيا وفي الاطفال و .. او .. او .. او .. او ..
+
+362
+00:27:03,030 --> 00:27:04,330
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+363
+00:27:04,330 --> 00:27:06,950
+.. او .. او .. او .. او .. او .. او .. او .. او ..
+
+364
+00:27:06,950 --> 00:27:07,770
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+365
+00:27:07,770 --> 00:27:08,070
+.. او .. او .. او .. او .. او .. او .. او .. او ..
+
+366
+00:27:08,070 --> 00:27:08,210
+او .. او .. او .. او .. او .. او .. او .. او .. او
+
+367
+00:27:08,210 --> 00:27:09,130
+.. او .. او .. او .. او .. او .. او .. او .. او ..
+
+368
+00:27:09,130 --> 00:27:15,210
+او .. او .. او .. او .. او
+
+369
+00:27:15,210 --> 00:27:18,330
+.. او .. ا
+
+370
+00:27:21,160 --> 00:27:25,640
+من خصائص هذا الفيروس ان الـ spikes فيها هيم
+
+371
+00:27:25,640 --> 00:27:30,820
+أجلوتينين، نيرو أميديز، وفيو جين بروتيم الـ fusion
+
+372
+00:27:30,820 --> 00:27:33,900
+protein مدينة صناعة مجموعات متنكلياتيجية مثلما
+
+373
+00:27:33,900 --> 00:27:36,380
+احنا هذا الكلام صرنا مكرين واميران واتكران في كل
+
+374
+00:27:36,380 --> 00:27:40,070
+بيارة ما يكسي فيروسالـ H و الـ N بروتين موجودين
+
+375
+00:27:40,070 --> 00:27:42,470
+على نفس الـ spike فكده لما قلنا لكوا ان
+
+376
+00:27:42,470 --> 00:27:46,250
+الانفلوانزا هي من الارثوميوكسي فيروس و قلنا لكوا
+
+377
+00:27:46,250 --> 00:27:49,930
+ان الارثوميوكسي فيروس تتميز بأنه كل مصادر موجودة
+
+378
+00:27:49,930 --> 00:27:53,770
+على نفس الـ spike لكن هنا الاثنين ممكن يكونوا
+
+379
+00:27:53,770 --> 00:27:57,090
+موجودين على نفس الـ spike إذا الـH و الـN موجودين
+
+380
+00:27:57,090 --> 00:28:02,170
+على نفس الـspike الـ F بروتين هو الـ Fusion بروتين
+
+381
+00:28:02,170 --> 00:28:06,380
+موجودة على نفس الـ spikeboth human and animals are
+
+382
+00:28:06,380 --> 00:28:10,760
+infected by parainfluenza viruses but the animal
+
+383
+00:28:10,760 --> 00:28:14,480
+strain do not infect human يعني مافيش cross خلّيني
+
+384
+00:28:14,480 --> 00:28:17,440
+نقول ال barrier بين الإنسان و الحيوان في هذا
+
+385
+00:28:17,440 --> 00:28:20,920
+الحالة موجود مافيش crossing مش زي ال influenza
+
+386
+00:28:20,920 --> 00:28:26,220
+الطيار ممكن يصيب الخنزير و ال human تصيب الخنزير
+
+387
+00:28:26,220 --> 00:28:30,080
+وبتالي بيصير فينا تبادل لأ هنا في عندي انفصال تمام
+
+388
+00:28:32,070 --> 00:28:35,290
+There are four types و احنا قلنا ان ال
+
+389
+00:28:35,290 --> 00:28:38,790
+parainfluenza من one to four في التصنيف تبعنا
+
+390
+00:28:38,790 --> 00:28:43,790
+which are distinguished by antigenicity يعني من
+
+391
+00:28:43,790 --> 00:28:46,710
+خلال الانتجينيات تبعاتهم cytopathic effect and
+
+392
+00:28:46,710 --> 00:28:52,230
+pathogenicity واضح انه ليس فقط الاختلاف
+
+393
+00:28:52,230 --> 00:28:56,130
+بالانتجينيات وانما ايضا بقدرتهم على احداث
+
+394
+00:28:56,130 --> 00:29:00,250
+cytopathic effect و بالأمراض اللي هم ايضا بيسببوها
+
+395
+00:29:00,790 --> 00:29:04,290
+Antibody to either the H or the F protein
+
+396
+00:29:04,290 --> 00:29:09,270
+neutralizes infectivity إذن كل مرة بجينا نقول إحنا
+
+397
+00:29:09,270 --> 00:29:13,610
+أن ال Antibody against Hemagglutinin neutralizes
+
+398
+00:29:13,610 --> 00:29:17,830
+infectivity للفيروسات اللي لها Hemagglutinin واللي
+
+399
+00:29:17,830 --> 00:29:22,850
+مالهاش Hemagglutinin كنا نقول أنه Antibody to
+
+400
+00:29:22,850 --> 00:29:29,560
+fusion proteinPromotes Neutralization للإنفكتفية،
+
+401
+00:29:29,560 --> 00:29:34,040
+تمام؟ هنا الـ Antibody لكل من اللي هو الـ
+
+402
+00:29:34,040 --> 00:29:37,460
+Hemagglutinin وله الـ F-Protein، قلنا بيعمل
+
+403
+00:29:37,460 --> 00:29:40,980
+Neutralizes Infectivity، وهذه يعني برضه حاجة
+
+404
+00:29:40,980 --> 00:29:47,610
+مختلفة عن الـ Other Virusطيب ال Parainfluenza
+
+405
+00:29:47,610 --> 00:29:51,250
+virus are best known as the main cause of croup in
+
+406
+00:29:51,250 --> 00:29:55,690
+children younger than 5 years of age.Croup is
+
+407
+00:29:55,690 --> 00:30:00,990
+characterized by harsh يعني خشن، harsh صعب، cough
+
+408
+00:30:00,990 --> 00:30:03,670
+and hoarseness، hoarseness اللي هي الصوت اللي قلنا
+
+409
+00:30:03,670 --> 00:30:09,210
+عنه هذا الفخم في الكحرIn addition to the group,
+
+410
+00:30:09,530 --> 00:30:11,930
+these viruses cause a variety of respiratory
+
+411
+00:30:11,930 --> 00:30:25,210
+diseases such as common cold فرنجايتس،
+
+412
+00:30:25,210 --> 00:30:28,530
+لرنجايتس، أوتايتس ميديا، برونكايتس and نيومونيا
+
+413
+00:30:33,920 --> 00:30:38,400
+طلعوا ال common cold الفرنجيتس، لارنجيتس، أوتايتس
+
+414
+00:30:38,400 --> 00:30:44,600
+ميديا، برونكايتس and نيمونياكلها أمراض للأسف للأسف
+
+415
+00:30:44,600 --> 00:30:50,840
+لما بيروح الطفل على الطبيب يا إما الطبيب نفسه من
+
+416
+00:30:50,840 --> 00:30:55,060
+malpractice من سوء إدارة في العلاج بيعطي
+
+417
+00:30:55,060 --> 00:30:59,660
+antibiotic أو بضغط من الأهالي أنه أعطي antibiotic
+
+418
+00:30:59,660 --> 00:31:04,100
+ضن من الناس أن ال antibiotic هو الحل السحري لكل
+
+419
+00:31:04,100 --> 00:31:10,450
+هذه الإشكالات للأسف وهذا يعنيالكلام اللى احنا
+
+420
+00:31:10,450 --> 00:31:14,010
+بنحكيه لان هو تأكيد لما نقوله ان نسبة كبيرة من
+
+421
+00:31:14,010 --> 00:31:17,010
+الأمراض اللى بنعطاه الها انت بتكون أمراض فيروسية
+
+422
+00:31:17,010 --> 00:31:22,890
+وكلكم يعلم حق المعرفة بإنه الفيروسات لا تستجيب
+
+423
+00:31:22,890 --> 00:31:27,610
+للمضادات الحيوية بأي حال من الأعوام فش غير فيروس
+
+424
+00:31:27,610 --> 00:31:33,310
+واحد مين بتذكره smallpoxلمين بيستجيب الهو
+
+425
+00:31:33,310 --> 00:31:39,410
+antibiotic بنقول انه ال antibiotic هذا اللي هو
+
+426
+00:31:39,410 --> 00:31:45,530
+Rifamicin كان effective او لجوا انه له activity
+
+427
+00:31:45,530 --> 00:31:51,230
+على ال smallpox تمام لكن لم يستخدم في ذاك الوقت
+
+428
+00:31:51,230 --> 00:31:54,950
+فلو صار في المستقبل في smallpox ممكن نستخدم مين؟
+
+429
+00:31:54,950 --> 00:31:57,990
+Rifamicin هذه المعلومة اعتقد انه مرت عليكم في ال
+
+430
+00:31:57,990 --> 00:32:03,050
+smallpoxLaboratory diagnoses, most infections are
+
+431
+00:32:03,050 --> 00:32:07,150
+diagnosed clinically. The diagnosis can be made in
+
+432
+00:32:07,150 --> 00:32:10,010
+the laboratory either by isolating the virus in
+
+433
+00:32:10,010 --> 00:32:14,370
+cell culture or by observing a fourfold or greater
+
+434
+00:32:14,370 --> 00:32:18,010
+rise in antibody titers.إذن هي نفس الفكرة في موضوع
+
+435
+00:32:18,010 --> 00:32:21,930
+الارتفاع في تركيز الانتيبادي.Treatment and
+
+436
+00:32:21,930 --> 00:32:26,770
+preventionThere is neither antiviral therapy nor a
+
+437
+00:32:26,770 --> 00:32:30,450
+vaccine available لكن غالبا ال disease self
+
+438
+00:32:30,450 --> 00:32:33,970
+-limited بمعنى انه بياخد فترة لكن فترة طويلة قد
+
+439
+00:32:33,970 --> 00:32:37,710
+تنتقل اسبوعين او اكتر بعد ذلك بيبدأ اللي هو الطفل
+
+440
+00:32:37,710 --> 00:32:40,250
+في ال recovery من ال group اللي جون عنه ال
+
+441
+00:32:40,250 --> 00:32:44,430
+hoarseness و ال harsh cough اللي وصفنا قبل قليل
+
+442
+00:32:44,430 --> 00:32:52,590
+نجي للفيروس صاحب التاج اللي هو coronavirusطبعا
+
+443
+00:32:52,590 --> 00:32:55,910
+كورونا فيروس كده المرة كانت شورته فقط ان هو احد
+
+444
+00:32:55,910 --> 00:33:01,790
+المسببات اللي هو ال common cold لكن انشهر بزيادة
+
+445
+00:33:01,790 --> 00:33:07,990
+لما اكتشفنا ان هو برضه بيسبب ال SARS وصارله اسم
+
+446
+00:33:07,990 --> 00:33:13,660
+ذائع صيط في الشرق الأوسط لما ارتبط اسمالـ Middle
+
+447
+00:33:13,660 --> 00:33:19,360
+East Respiratory Syndrome Coronavirus اللي هو لحد
+
+448
+00:33:19,360 --> 00:33:24,760
+الآن موجود في مناطق الخليج العربي ويعني يحدث حالات
+
+449
+00:33:24,760 --> 00:33:28,960
+متفارقة هنا و هناك و هناك انه تم ربطه مع اللي هو
+
+450
+00:33:28,960 --> 00:33:34,210
+الجمال يعني انتقاله عبر اللي هو الجماللم ترتقي ال
+
+451
+00:33:34,210 --> 00:33:37,610
+evidence إلى انه بتكون absolute cause and effect
+
+452
+00:33:37,610 --> 00:33:43,650
+لكن القول الدارج والشائع ان الجمال هي الناقل لهذا
+
+453
+00:33:43,650 --> 00:33:44,470
+الفيروس
+
+454
+00:33:47,580 --> 00:33:50,620
+Coronavirus are important cause of common cold,
+
+455
+00:33:50,740 --> 00:33:56,420
+probably second only to rhinovirus infrequency،
+
+456
+00:33:56,420 --> 00:34:04,220
+في الـ 2002،
+
+457
+00:34:04,220 --> 00:34:08,670
+a new diseasean atypical pneumonia وكلمة atypical
+
+458
+00:34:08,670 --> 00:34:13,350
+يعني نيمونيا غير نمطية وكلمة غير نمطية يعني عشان
+
+459
+00:34:13,350 --> 00:34:16,790
+نميز أي نيمونيا تختلف عن ال bacterial pneumonia
+
+460
+00:34:16,790 --> 00:34:20,850
+most commonly caused by a set of caucases
+
+461
+00:34:20,850 --> 00:34:24,890
+النيمونيا بيسموها atypical نيمونيا كلمة atypical
+
+462
+00:34:24,890 --> 00:34:29,490
+نيمونيا تعني غير نمطية غير نمطية في بكتيريا ال
+
+463
+00:34:29,490 --> 00:34:32,570
+micro plasma بتسبب atypical نيمونيا يعني في other
+
+464
+00:34:32,570 --> 00:34:36,860
+causes of atypical نيمونياهذه الاتميكال نيومونيا
+
+465
+00:34:36,860 --> 00:34:41,000
+سميناها SARS اللي يقول عنها Severe Acute
+
+466
+00:34:41,000 --> 00:34:46,020
+Respiratory Syndrome الكورونا
+
+467
+00:34:46,020 --> 00:34:49,200
+فايروسز هف انان سيجمنت single-stranded positive
+
+468
+00:34:49,200 --> 00:34:54,220
+polarity RNA جينوم اللي هنتكلم عنه الآن عن
+
+469
+00:34:54,220 --> 00:34:59,410
+positive polarity مش negative polarityHelical
+
+470
+00:34:59,410 --> 00:35:02,770
+Nucleocapsid هم فيروسات محلية مع نوكليوكبسيد
+
+471
+00:35:02,770 --> 00:35:06,570
+تختلفت الآن عن البراميوكسي فيروسات في ايش في ان
+
+472
+00:35:06,570 --> 00:35:09,770
+بوستف و بولاريته كانوا كلهم نيجاتيف بولاريته
+
+473
+00:35:19,850 --> 00:35:24,690
+لعنة زي ال racket club shape in the form of
+
+474
+00:35:24,690 --> 00:35:28,250
+corona's halos، واحنا قلنا ان الكورونا بتشبه التاج
+
+475
+00:35:28,250 --> 00:35:33,900
+يعني، بتشبه التاج، can be seenفي سؤالتين واحدة
+
+476
+00:35:33,900 --> 00:35:41,160
+بيسموها 229E واحدة بيسموها OC43 ال genome sequence
+
+477
+00:35:41,160 --> 00:35:44,660
+لل coronavirus caused SARS اللي هو coronavirus
+
+478
+00:35:44,660 --> 00:35:48,000
+SARS outbreak is different from the existing human
+
+479
+00:35:48,000 --> 00:35:51,540
+strain اللي هو بسبب الرشح يعني كان في اختلاف بين
+
+480
+00:35:51,540 --> 00:35:58,180
+التانينوgenome typical coronavirus في التصنيف يعني
+
+481
+00:35:58,180 --> 00:36:01,600
+they are coronavirus لكن ال genome sequence معهم
+
+482
+00:36:01,600 --> 00:36:04,600
+مختلف بمعنى أنه بالفعل فيهم اختلافات في ال
+
+483
+00:36:04,600 --> 00:36:07,000
+characteristics لهذين الفيروسين
+
+484
+00:36:18,850 --> 00:36:21,030
+Coronavirus are transmitted by the respiratory
+
+485
+00:36:21,030 --> 00:36:25,090
+aerosols اللي برضه بالرذاب، لاحظوا لحد الآن كل
+
+486
+00:36:25,090 --> 00:36:28,710
+مجموعة من ال RNA enveloped viruses are transmitted
+
+487
+00:36:28,710 --> 00:36:32,930
+في جنها via respiratory aerosols Infection occurs
+
+488
+00:36:32,930 --> 00:36:36,490
+worldwide and can ..الان أنا بتكلمش عن ال stars،
+
+489
+00:36:36,490 --> 00:36:38,790
+بتكلم عن ال coronavirus بشكل عام
+
+490
+00:36:42,660 --> 00:36:47,140
+أكتر من خمسين بالمائة من الأطفال أكتر من خمسين
+
+491
+00:36:47,140 --> 00:36:48,420
+بالمائة من الأطفال أكتر من خمسين بالمائة من
+
+492
+00:36:48,420 --> 00:36:49,040
+الأطفال أكتر من خمسين بالمائة من الأطفال أكتر من
+
+493
+00:36:49,040 --> 00:36:49,180
+خمسين بالمائة من الأطفال أكتر من خمسين بالمائة من
+
+494
+00:36:49,180 --> 00:36:50,520
+الأطفال أكتر من خمسين بالمائة من الأطفال أكتر من
+
+495
+00:36:50,520 --> 00:36:52,380
+خمسين بالمائة من الأطفال أكتر من خمسين بالمائة من
+
+496
+00:36:52,380 --> 00:36:56,100
+الأطفال أكتر من خمسين بالمائة من الأطفال أكتر من
+
+497
+00:36:56,100 --> 00:37:03,380
+خمسين بالمائة من الأطفال أكتر من خمسين بالمائة من
+
+498
+00:37:03,380 --> 00:37:05,860
+الأطفال أكتر من خمسلسه ما ننسى اللي بحاجتنا عشان
+
+499
+00:37:05,860 --> 00:37:08,920
+ننساه لما قلنا قبل قليل ال respiratory syncytial
+
+500
+00:37:08,920 --> 00:37:14,420
+virus بيختلف عن باقي الفيروسات بإنه كل فصل شتاء
+
+501
+00:37:14,420 --> 00:37:20,340
+بينتشر بس هاله كل سنتين إلى تلات سنواتسارس أصبح
+
+502
+00:37:20,340 --> 00:37:26,160
+مصر في نوفمبر 2002 وانتقل
+
+503
+00:37:26,160 --> 00:37:30,020
+إلى بلدان أخرى في برضه منطقة جنوب الشرق أسيا
+
+504
+00:37:53,840 --> 00:37:57,040
+والمرة الجاية ان شاء الله بنكمل ال transmission و
+
+505
+00:37:57,040 --> 00:37:57,600
+ال Epidemiology
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/xKnJDZSReSo_raw.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/xKnJDZSReSo_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..701dff3c9724858e15c7ab7c30b6c9a0040e5a07
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/xKnJDZSReSo_raw.srt
@@ -0,0 +1,2024 @@
+1
+00:00:20,820 --> 00:00:23,680
+بسم الله الرحمن الرحيم اليوم ان شاء الله هنتناول
+
+2
+00:00:23,680 --> 00:00:30,340
+موضوع جديد هو الأطول في مواضيع ال ال virology و هي
+
+3
+00:00:30,340 --> 00:00:35,200
+مجموعة ال RNA enveloped viruses و عشان احنا نقدر
+
+4
+00:00:35,200 --> 00:00:39,540
+ناخد فكرة عن ال chapter تبعنا مجموعة الفيروسات
+
+5
+00:00:39,540 --> 00:00:43,740
+اللي هندرسها أو بعضا منها ملخصة في جدول بسيط نتعرف
+
+6
+00:00:43,740 --> 00:00:47,100
+على هذا الجدول ثم ندخل على اول فيروس ان شاء الله
+
+7
+00:00:48,910 --> 00:00:53,270
+لدينا مجموعة من الأعمدة ال virus ال disease ال
+
+8
+00:00:53,270 --> 00:00:57,070
+number of serotypes هل بيعطي life long immunity
+
+9
+00:00:57,070 --> 00:01:00,690
+إذا وصيب في الإنسان أو الطعم له هل هناك أصلا
+
+10
+00:01:00,690 --> 00:01:06,650
+vaccine لهذا ال virus و هل هناك latency لل virus
+
+11
+00:01:06,650 --> 00:01:10,870
+زي ما كنا نشوف في ال herpes viruses أو في ال adeno
+
+12
+00:01:10,870 --> 00:01:13,810
+viruses و بالنسبة لل treatment هل هناك antiviral
+
+13
+00:01:13,810 --> 00:01:17,810
+drug ولا مافيشنختصر المسافة ونطلع على الـ latency
+
+14
+00:01:17,810 --> 00:01:22,130
+هل في واحد منهم فيها اندو لتانسي كلهم نيجاتيب
+
+15
+00:01:22,130 --> 00:01:28,410
+مافيش اي من ال RNA انفلوت بايرس بيعمل latencyبنسبة
+
+16
+00:01:28,410 --> 00:01:33,070
+للعقاقير معظمهم اللي هم مش antiviral drug إلا اللي
+
+17
+00:01:33,070 --> 00:01:36,850
+هم ال respiratory syncytial virus واسمه ribavirin
+
+18
+00:01:36,850 --> 00:01:41,430
+اللي هو اسم ال antiviral drug وبنسبة ال influenza
+
+19
+00:01:41,430 --> 00:01:45,410
+الحقيقة أنه في مجموعة لا بأس بيها من ال antiviral
+
+20
+00:01:45,410 --> 00:01:48,990
+drugs زي ال amantadine و ال rimantadine و ال
+
+21
+00:01:48,990 --> 00:01:52,470
+oseltamivir و zanamivir طبعا هنفهمهم هدولة بشكل
+
+22
+00:01:52,470 --> 00:01:56,110
+خاص لأن ال influenza هي نجم هذه المحاضرات ان شاء
+
+23
+00:01:56,110 --> 00:02:00,440
+الله اليوم و القادمة بإذن اللهالامانتدين
+
+24
+00:02:00,440 --> 00:02:04,740
+والريمانتدين بيشتغلوا على اتجاه معين بينما الاصل
+
+25
+00:02:04,740 --> 00:02:08,760
+تمافير والزنمافير بيشتغلوا على اتجاه اخر ايش
+
+26
+00:02:08,760 --> 00:02:12,320
+الاتجاهين هنعرفهم ان شاء الله لما ندرس تركيب فيروس
+
+27
+00:02:12,320 --> 00:02:15,720
+الانفلوانزا بإذن اللهطب تعال تلع ال vaccination هل
+
+28
+00:02:15,720 --> 00:02:18,520
+في available vaccine و لا مافيش available vaccine؟
+
+29
+00:02:18,520 --> 00:02:23,620
+هلاج أنه مجموعة معروفة لديكم اللي هي الربلا و ال
+
+30
+00:02:23,620 --> 00:02:28,400
+missiles و ال mumps كله لها vaccine بالاضافة لمين؟
+
+31
+00:02:28,400 --> 00:02:32,340
+لل influenza و ال influenza .. ممكن نقشنا قبلك ال
+
+32
+00:02:32,340 --> 00:02:35,180
+vaccine تبعها اللي قلتلكوا أن هو عبارة عن مجموعة
+
+33
+00:02:35,180 --> 00:02:38,580
+من السلالات كانت بتدور في العالم .. العالم الماضي
+
+34
+00:02:38,960 --> 00:02:41,940
+لكن هذا لا يعني ان اللي أخذ ال vaccine ان هو
+
+35
+00:02:41,940 --> 00:02:47,460
+totally protected قد يصاب لكن احتمالية الإصابة
+
+36
+00:02:47,460 --> 00:02:53,240
+بتجل عن الناس اللي ماخدوش ال vaccineطيب هل بيعطينا
+
+37
+00:02:53,240 --> 00:02:58,560
+lifelong immunity؟ اتطلعوا على التلاتة اللي هم ال
+
+38
+00:02:58,560 --> 00:03:03,020
+MMR الربلة و ال missiles و ال mumps بيلاجوا نعم
+
+39
+00:03:03,020 --> 00:03:06,840
+بيعطيهم long life immunity وهذا سر نجاح من
+
+40
+00:03:06,840 --> 00:03:11,480
+الفاكسين سر نجاح الفاكسين أيضا ان انا عندي zero
+
+41
+00:03:11,480 --> 00:03:15,240
+type كام واحد؟ one one one يعني مافيش only one
+
+42
+00:03:15,240 --> 00:03:20,530
+zero type وهذا أيضا سبب نجاح لهذا الفاكسينبينما
+
+43
+00:03:20,530 --> 00:03:24,170
+تعالى تطلع على ال influenza صحيح فيه vaccine لكنه
+
+44
+00:03:24,170 --> 00:03:29,110
+مابتطناش long life لأنه فيه هنا كمان ماني سيرو
+
+45
+00:03:29,110 --> 00:03:33,550
+types البارا influenza ايضا ماني سيرو types اذا
+
+46
+00:03:33,550 --> 00:03:37,670
+طبعا ال coronavirus احنا ماقراهش أسماء الفيروسات
+
+47
+00:03:37,670 --> 00:03:42,190
+لكن ال coronavirus مشهور بأنه من فيروسات الرشح
+
+48
+00:03:43,240 --> 00:03:47,800
+لتعمل common cold تمام common cold لكن انشهر اكتر
+
+49
+00:03:47,800 --> 00:03:52,740
+لما ال SARS نعم لما ظهر ال SARS انشهر كتير والان
+
+50
+00:03:52,740 --> 00:03:56,840
+مشهور اكتر في ال middle east لان في فيروس جديد من
+
+51
+00:03:56,840 --> 00:03:59,880
+عامين تقريبا صار له بيلفلف في الخارج العربي اللي
+
+52
+00:03:59,880 --> 00:04:04,880
+هو ال MERS-CoV CoV يعني coronavirus و MERS معناها
+
+53
+00:04:04,880 --> 00:04:09,810
+Middle East Respiratory Syndromeيعني اضطبط هذا الـ
+
+54
+00:04:09,810 --> 00:04:13,150
+syndrome في منطقة الشرق الأوسط وتحديدا في السعودية
+
+55
+00:04:13,150 --> 00:04:18,830
+والخليج العربي وكانت دراسات بودرة العامين الماضيين
+
+56
+00:04:18,830 --> 00:04:24,850
+لتحديد جهة الانتقال والان المتهم الأكبر هو الجمل
+
+57
+00:04:24,850 --> 00:04:30,940
+هو حيوان الجملنجيب طول على الفيروسات نفسها
+
+58
+00:04:30,940 --> 00:04:33,480
+انفلوانزا و اليوم احنا كبرنا و بعدين نقول
+
+59
+00:04:33,480 --> 00:04:37,860
+انفلوانزا و خلاص و بعدين نقول انفلوانزا a و b و c
+
+60
+00:04:37,860 --> 00:04:41,560
+يعني في أنواع مختلفة غير على السلالات اللي كنا
+
+61
+00:04:41,560 --> 00:04:44,600
+بنتكلم عنها ك strings لأ اللي هنتكلم عن أصناف
+
+62
+00:04:44,600 --> 00:04:49,800
+رئيسية a و b و c ال para influenza بتسبب مرض مكروب
+
+63
+00:04:49,800 --> 00:04:53,020
+وهو عبارة عن dry cough بصيب الأطفال نوع من الكحة
+
+64
+00:04:53,020 --> 00:04:58,570
+الجافة سيئة الصمة و مؤلمة للأطفالالـ Respiratory
+
+65
+00:04:58,570 --> 00:05:02,230
+syncytial virus بيعمل الـ Broncolitis الربلة بتعمل
+
+66
+00:05:02,230 --> 00:05:05,050
+الربلة اللي هي ال German missiles أو الحمّة أفضل
+
+67
+00:05:05,050 --> 00:05:08,990
+حصبة الألمانية و ال missiles اللي هي الحصبة تمام؟
+
+68
+00:05:08,990 --> 00:05:11,870
+و ال mumps اللي هو ال .. ال .. ال .. ال terror غضب
+
+69
+00:05:11,870 --> 00:05:15,130
+النكافية اللي احنا مسامير العام يقولنا أبو داجي ال
+
+70
+00:05:15,130 --> 00:05:19,030
+Rhino virus هو الأشهر على الإطلاق فيه كفيروس لرشح
+
+71
+00:05:19,030 --> 00:05:23,310
+الآن صار عندنا اليوم تلت فيروسات بتعرفوهم بيعملوا
+
+72
+00:05:23,310 --> 00:05:25,450
+common cold من هما التلاتة
+
+73
+00:05:29,760 --> 00:05:37,600
+الثالث هو ال adenovirus الكوكساكي فيروس أيضًا من
+
+74
+00:05:37,600 --> 00:05:42,460
+الفيروسات المهمة و اللي بتعمل myocarditis يعني
+
+75
+00:05:42,460 --> 00:05:46,100
+ممكن تأثر على عضلة القلب
+
+76
+00:05:49,060 --> 00:05:53,900
+عندي خمس أصناف من ال RNA viruses ال envelope RNA
+
+77
+00:05:53,900 --> 00:05:59,460
+viruses من نجوم المجموعة بنحاول برضه نعمل بينهم
+
+78
+00:05:59,460 --> 00:06:03,220
+مقارنة طلعولي طبعا ال rabies ماكانش موجود في
+
+79
+00:06:03,220 --> 00:06:10,720
+القائمة حاطناه في القائمة وال rabies هو أخطر فيروس
+
+80
+00:06:10,720 --> 00:06:16,550
+على وجه الأرض عشان نقول Ebolaوبنقول ماربورغ بس
+
+81
+00:06:16,550 --> 00:06:20,570
+نسبة الوفيات في إيبولا وماربورغ حوالي من خمسة
+
+82
+00:06:20,570 --> 00:06:25,250
+وسبعين لماربورغ إلى تسعين لإيبولا بس هذا مائة
+
+83
+00:06:25,250 --> 00:06:29,670
+بالمائة ال mortality rate لل .. للفيروس هذا مائة
+
+84
+00:06:29,670 --> 00:06:34,050
+بالمائة إذا لم يعالج المريض مائة بالمائة سوف يموت
+
+85
+00:06:34,050 --> 00:06:37,930
+اقولك يعني حتى معلوماتنا عن مناعة هذا الفيروس
+
+86
+00:06:37,930 --> 00:06:45,250
+ضعيفة لإنه مافيش أحياءنجوا من هذا المرض بمنعاتهم
+
+87
+00:06:45,250 --> 00:06:48,810
+هم من غير تدخلنا احنا يعني فمش قادرين نفهم المناعة
+
+88
+00:06:48,810 --> 00:06:55,090
+تبعته او ضده كيف بدها اتصال اذا ال rabies virus من
+
+89
+00:06:55,090 --> 00:06:58,330
+الفيروسات الخطيرة اللي حياتنا درستها في هذا الفصل
+
+90
+00:06:58,330 --> 00:07:01,730
+ان شاء الله هي الوحيدة اللي بنمتلكلها
+
+91
+00:07:01,730 --> 00:07:05,510
+immunoglobulins واذا فاكرين لما درسنا ال vaccines
+
+92
+00:07:05,510 --> 00:07:10,990
+تبع ال viruses قلنا هناك صفتين بيمتلكهم ال rabies
+
+93
+00:07:10,990 --> 00:07:15,530
+virusان انا بقدر اعمله vaccine بعد التعرض اللي
+
+94
+00:07:15,530 --> 00:07:19,910
+يسمينها post exposure صح؟ و هو الوحيد او مش الوحيد
+
+95
+00:07:19,910 --> 00:07:24,170
+هو كمان يمتلك صفة انه passive active immunization
+
+96
+00:07:24,170 --> 00:07:27,850
+بعطيه immunoglobulin و بعطيه vaccine في نفس الوقت
+
+97
+00:07:27,850 --> 00:07:32,560
+اتنين امتلكوا هذه الصفة تانيالـ Hepatitis B فيروس
+
+98
+00:07:32,560 --> 00:07:35,680
+والـ rabies فيروس إذن هو الوحيد اللي اللي له
+
+99
+00:07:35,680 --> 00:07:39,020
+منيونoglobulin في هذه القائمة بالنسبة لل vaccines
+
+100
+00:07:39,020 --> 00:07:43,000
+فيه killed وفيه live vaccine طبعا ال missiles و
+
+101
+00:07:43,000 --> 00:07:48,340
+الربلة بعضنا live او كهم live vaccine وسبب نجاحهم
+
+102
+00:07:48,340 --> 00:07:52,860
+أساسا في إنهم يحمونا من ال missiles و من الربلة و
+
+103
+00:07:52,860 --> 00:07:56,420
+من ال moms إنهم live vaccines إيش ميزة ال live
+
+104
+00:07:56,420 --> 00:08:02,410
+vaccine برضه نسترجع مع بعض ال vaccinationال live
+
+105
+00:08:02,410 --> 00:08:05,830
+vaccine او ال live virus بيعمل multiplication و
+
+106
+00:08:05,830 --> 00:08:09,070
+لما يعمل multiplication هذا بيحفظ مش بس ال
+
+107
+00:08:09,070 --> 00:08:11,670
+antibody production و ان انا يحفظ أيضا ال cell
+
+108
+00:08:11,670 --> 00:08:14,970
+mediated immunity وبالتالي انا ال immune system
+
+109
+00:08:14,970 --> 00:08:18,330
+الكامل اللي المفروض يشتغل زي ال natural infection
+
+110
+00:08:18,330 --> 00:08:22,510
+يشتغل عندي بال vaccination فال live كانت مزايا انه
+
+111
+00:08:22,510 --> 00:08:27,650
+بالفعل longer immunityطبعا ال influenza killed
+
+112
+00:08:27,650 --> 00:08:31,450
+vaccine و ال rabies أيضا killed vaccine ايش سبب
+
+113
+00:08:31,450 --> 00:08:36,590
+نجاحنا انه نستخدم ال vaccine تبع ال rabies post
+
+114
+00:08:36,590 --> 00:08:42,710
+exposure بعد ما اتعرض انه في long incubation
+
+115
+00:08:42,710 --> 00:08:46,630
+period لمن؟ للفيروس وبالتالي انا بعطي فرصة كويسة
+
+116
+00:08:46,630 --> 00:08:49,990
+لجازي المنع ان يكون immunity من ال vaccine مباشرة
+
+117
+00:08:49,990 --> 00:08:56,400
+قبل ما يتكون او قبل ما الفيروس يعنييصل لحالة المرض
+
+118
+00:08:56,400 --> 00:09:03,020
+طيب فينا عمودين العمود الأول بيحتوي على
+
+119
+00:09:03,020 --> 00:09:07,380
+Orthomyoxivirida أو Orthomyoxivirus و
+
+120
+00:09:07,380 --> 00:09:12,560
+Paramyoxivirus طيب احنا بنتكلم على مسميين متشابهين
+
+121
+00:09:12,560 --> 00:09:16,840
+تماما اللي هم Myoxivirus لكن واحد اعطانا اسم Orth
+
+122
+00:09:16,840 --> 00:09:22,120
+و واحد اعطانا اسم Paraالان التفريقة أو الشبه بينهم
+
+123
+00:09:22,120 --> 00:09:25,820
+ان الاتنين يلهم high affinity لالميوسين اللى هو
+
+124
+00:09:25,820 --> 00:09:30,890
+المخاطر و هو عبارة عن ال glycoprotein بالمناسبةلكن
+
+125
+00:09:30,890 --> 00:09:34,110
+لو جينا نتطلع على المجموعتين هلاجى كتير فروقات
+
+126
+00:09:34,110 --> 00:09:38,850
+بينهم غير الشبه اللى احنا ذكرناها مثلا الأعضاء
+
+127
+00:09:38,850 --> 00:09:41,130
+تبعتهم فقط ال influenza و ال influenza اللى اول
+
+128
+00:09:41,130 --> 00:09:44,770
+مرة جسمناها انفلونزا A و B و C بينما ال
+
+129
+00:09:44,770 --> 00:09:48,370
+paramycobiruses بتحتوي على ال missiles و ال mumps
+
+130
+00:09:48,370 --> 00:09:50,690
+و ال respiratory syncytial virus و ال
+
+131
+00:09:50,690 --> 00:09:55,600
+parainfluenza virus اذا مجموعة كبيرةدمن اللي هم ال
+
+132
+00:09:55,600 --> 00:09:58,580
+Paramyoxic virus بينما only one single species
+
+133
+00:09:58,580 --> 00:10:01,340
+اللي هي ال influenza في ال orthomyoxic virus
+
+134
+00:10:04,020 --> 00:10:07,520
+التانين بيحتووا على RNA Negative Sense تاكرين
+
+135
+00:10:07,520 --> 00:10:11,320
+Negative Sense؟ Negative Sense RNA لكن في فرق
+
+136
+00:10:11,320 --> 00:10:15,640
+بينهم واحد segmented مجزق مقطع والتاني non
+
+137
+00:10:15,640 --> 00:10:20,120
+-segmented بما أنهم التانين بيحتووا على Negative
+
+138
+00:10:20,120 --> 00:10:25,080
+Sense RNA يبقى بدهم RNA dependent RNA polymerase
+
+139
+00:10:25,080 --> 00:10:29,960
+ويبقى الجينوم تبعهم non-infectious غير مواضي بمعنى
+
+140
+00:10:29,960 --> 00:10:34,850
+لو نقل لحال الجينوم مش هقدر يعمل infectionOkay هاي
+
+141
+00:10:34,850 --> 00:10:37,770
+الخطوة التانية ال Varian RNA polymerase نعم موجود
+
+142
+00:10:37,770 --> 00:10:41,570
+نعم موجود ال capsid helical helical تنتم بتشابه
+
+143
+00:10:41,570 --> 00:10:44,370
+بهذا الموضوع ال envelope اللي هم أصلا ندرسهم
+
+144
+00:10:44,370 --> 00:10:47,710
+قاعدين عامل تحت نفس العنوان ال size ال
+
+145
+00:10:47,710 --> 00:10:52,230
+orthomyoxiviruses أصغر شوية من ال paramyoxiviruses
+
+146
+00:10:52,230 --> 00:10:56,370
+طبعا 110 nanometer ل 150 يعني في فرق 40 nanometer
+
+147
+00:10:56,370 --> 00:11:00,790
+دولة كويسين يعني surface spikes أحدث مهم كتير
+
+148
+00:11:01,630 --> 00:11:04,830
+بتعرفوا أن الـ Envelope Membrane بيكون فيه عليها
+
+149
+00:11:04,830 --> 00:11:09,290
+Spikes، الـ glycoprotein بتكون غالبا من الفيروس،
+
+150
+00:11:09,290 --> 00:11:13,570
+في الارثميوكسفيروس، يعني الانفلوانزا، بنلاقي انه
+
+151
+00:11:13,570 --> 00:11:17,990
+two different، two distinct spikes، واحد اسمه
+
+152
+00:11:17,990 --> 00:11:22,680
+Hemagglutinin، وواحد اسمه Neuroaminidaseعلى وجهها
+
+153
+00:11:22,680 --> 00:11:27,000
+التانية بنلاقي one single spike بيحتوى على الصفتين
+
+154
+00:11:27,000 --> 00:11:30,280
+أنه Neuroaminidase و Hemagglutinin في نفس الوقت،
+
+155
+00:11:30,280 --> 00:11:34,060
+إذن two in one هدا في مين؟ في ال Paramyoxic لكن
+
+156
+00:11:34,060 --> 00:11:38,400
+two distinct في مين؟ في ال Orthomyoxic virus، طبعا
+
+157
+00:11:38,400 --> 00:11:43,100
+بنادوا انها الكل Hemagglutininوالـ Neuroaminidase
+
+158
+00:11:43,100 --> 00:11:46,580
+من أهم التراكيب على ال influenza viruses وانتوا
+
+159
+00:11:46,580 --> 00:11:52,780
+سمعتوا H5N1 H1N1 ال H هي ال heme agglutinin و ال N
+
+160
+00:11:52,780 --> 00:11:56,800
+هي ال neuroaminidase و هنتكلم عن وظائفهم بعد قليل
+
+161
+00:11:56,800 --> 00:12:01,240
+ان شاء اللهالنقطة الأخيرة في الجدول Giant Cell
+
+162
+00:12:01,240 --> 00:12:05,740
+Formation هل هي تكون خلية عملاقة في الارثو مايوكسي
+
+163
+00:12:05,740 --> 00:12:09,360
+فيروس نو الاجابة بينما في ال بارا مايوكسي فيروس
+
+164
+00:12:09,360 --> 00:12:12,320
+اتذكروا انه متكلم عن مين احنا؟ عن Respiratory
+
+165
+00:12:12,320 --> 00:12:16,360
+Syncytial اصلا كلمة Syncytia جاء من كلمة Giant
+
+166
+00:12:16,360 --> 00:12:21,250
+Cellهذا هو الفيروس الجابير تبع ال Influenza نتطلع
+
+167
+00:12:21,250 --> 00:12:24,110
+على الـ Neuroaminidase في المنطقة هذه اللي هي
+
+168
+00:12:24,110 --> 00:12:28,110
+باللون الأصفر و ال Hemagglutinin اللي هي باللون
+
+169
+00:12:28,110 --> 00:12:31,270
+الزهري أو البنفسجي مش عارف إيش اللون البنفسجي هال
+
+170
+00:12:31,270 --> 00:12:36,940
+ولا إيش بنسميه؟وتكوّن على الجينوم بيلاقي انه واحد
+
+171
+00:12:36,940 --> 00:12:42,980
+اتنين تلاتة اربع خمسة ستة سبعة تمانية تمان قطع من
+
+172
+00:12:42,980 --> 00:12:47,720
+الـ Negative Sins RNA each segment بنات codes for
+
+173
+00:12:47,720 --> 00:12:51,700
+one single protein يعني بيعملوا coding لبروتين
+
+174
+00:12:51,700 --> 00:12:58,880
+واحدبالإضافة إلى اللي هم ال polymerases حكينا قبل
+
+175
+00:12:58,880 --> 00:13:03,440
+قليل إن هدولة negative sins و لازم يحملوا معاهم ال
+
+176
+00:13:03,440 --> 00:13:08,120
+RNA dependent RNA polymerase لأن خلايانها لا تحتوي
+
+177
+00:13:08,120 --> 00:13:13,550
+على هذه الانزيمةالإنفلوانزا فيروس هم الوحيدين من
+
+178
+00:13:13,550 --> 00:13:18,810
+عائلة الورثو مايوكسي فيروس الورثو مايوكسي فيروس
+
+179
+00:13:18,810 --> 00:13:20,370
+الورثو مايوكسي فيروس الورثو مايوكسي فيروس الورثو
+
+180
+00:13:20,370 --> 00:13:22,870
+مايوكسي فيروس الورثو مايوكسي فيروس الورثو مايوكسي
+
+181
+00:13:22,870 --> 00:13:26,110
+فيروس الورثو مايوكسي فيروس الورثو مايوكسي فيروس
+
+182
+00:13:26,110 --> 00:13:27,450
+الورثو مايوكسي فيروس الورثو مايوكسي فيروس الورثو
+
+183
+00:13:27,450 --> 00:13:32,770
+مايوكسي فيروس الورثو مايوكسي فيروس الورثو
+
+184
+00:13:32,770 --> 00:13:37,450
+مايوكسي فيروس الورثو مايوكسي فيروس الورثو ماي
+
+185
+00:13:38,390 --> 00:13:40,510
+والميوسين هو اللي قلناه الـ glycoprotein اللي
+
+186
+00:13:40,510 --> 00:13:45,230
+موجود على أسطح بعض الخلايا من جسم الإنسان الحاجة
+
+187
+00:13:45,230 --> 00:13:48,790
+اللي محكينا عنه أن الـ Orth هو أصغر بقليل من الـ
+
+188
+00:13:48,790 --> 00:13:52,970
+Paramyoxic virus الان هيجي نتكلم عن الثلاث أنواع
+
+189
+00:13:52,970 --> 00:13:58,930
+من الفيروسات اللي هم influenza A وB وCطبعا كلمة
+
+190
+00:13:58,930 --> 00:14:03,570
+pandemic مرتبطة بمين؟ ب influenza ايه؟ وإيش معناه
+
+191
+00:14:03,570 --> 00:14:08,610
+pandemic؟ pandemic معناها إن ال disease has spread
+
+192
+00:14:08,610 --> 00:14:12,750
+in more than two countries in two continents، إيش
+
+193
+00:14:12,750 --> 00:14:17,890
+يعني؟ يعني بلدين أو أكتر في قارتين مختلفتين، يعني
+
+194
+00:14:17,890 --> 00:14:22,800
+أفريقيا وأوروبادولتين و اكتر دولتين و اكتر بنسميه
+
+195
+00:14:22,800 --> 00:14:26,300
+pandemic و باللغة العربية بنسميها جائحة من ان ال
+
+196
+00:14:26,300 --> 00:14:30,460
+.. ال .. الوباء قد اشتاقها مناطق يعني واسعة هذا
+
+197
+00:14:30,460 --> 00:14:33,640
+اسمه pandemic اللي بيقوم في ال pandemic غالبا هو
+
+198
+00:14:33,640 --> 00:14:39,300
+مين؟ influenza B influenza B بتعمل major outbreaks
+
+199
+00:14:39,300 --> 00:14:45,180
+of influenza ايش يعني outbreak؟outbreak معناه تفشي
+
+200
+00:14:45,180 --> 00:14:51,540
+والتفشي هو وصف لانتشار سريع ومفاجئ لأي مرض في أي
+
+201
+00:14:51,540 --> 00:14:54,900
+مكان، بيختلف عن ال epidemic ال epidemic معناها
+
+202
+00:14:54,900 --> 00:15:00,200
+زيادة في عادل الحالات عن الأعوام السابقة وال
+
+203
+00:15:00,200 --> 00:15:07,010
+endemicهو مرض مستوطن يحدث at constant rates يعني
+
+204
+00:15:07,010 --> 00:15:14,050
+بنسب ثابتة في مكان ما فبنسميه مستوطن لو زاد هذا ال
+
+205
+00:15:14,050 --> 00:15:17,550
+endemic عن حده في الأعوام القادمة بنسميه epidemic
+
+206
+00:15:17,550 --> 00:15:21,870
+لو انتشر انتشار سريع و مفاري بنسميه outbreak لو
+
+207
+00:15:21,870 --> 00:15:26,090
+انتشر في دولتين او اكثر في قارتين بنسميه pandemic
+
+208
+00:15:26,090 --> 00:15:30,070
+افضل ان المصطلحات هتكون يعني قد يعني دخلت الذاكرة
+
+209
+00:15:30,070 --> 00:15:35,520
+وما تخرج منها ان شاء اللهطبعا هذا لا يعني ان ال
+
+210
+00:15:35,520 --> 00:15:38,940
+influenza A ما بتسببش outbreaks اللي بتسبب برضه
+
+211
+00:15:38,940 --> 00:15:42,260
+outbreaks بس هي المشهورة اللي بتسبب ال pandemics
+
+212
+00:15:42,260 --> 00:15:46,220
+influenza C can cause mild respiratory tract
+
+213
+00:15:46,220 --> 00:15:49,380
+infection but does not cause outbreaks of
+
+214
+00:15:49,380 --> 00:15:56,480
+influenza يعني ال C هي الأقل خطورة من B و من Aفي
+
+215
+00:15:56,480 --> 00:16:07,170
+1968 حدث وباء بإنفلوانزا pandemic يعني جائحةلكن
+
+216
+00:16:07,170 --> 00:16:12,190
+بعد ما انتهت هذه الجائحة أصبح ده نرى أن هذه
+
+217
+00:16:12,190 --> 00:16:18,590
+السلالة اللي سببت جائحة 1968 صارت تعمل outbreaks
+
+218
+00:16:18,590 --> 00:16:22,070
+في أماكن مختلفة من العالم، يعني مش في نفس الوقت،
+
+219
+00:16:22,070 --> 00:16:25,650
+في وقت مختلفة، فأصبحت ضمن مين؟ ضمن ما يسمى
+
+220
+00:16:25,650 --> 00:16:27,170
+بالإنفلوانزا الموسمية
+
+221
+00:16:32,280 --> 00:16:36,200
+Each year influenza هده هده جملة مهمة جدا يعرفها
+
+222
+00:16:36,200 --> 00:16:40,400
+عن هذا المرض الخطير Most common cause of
+
+223
+00:16:40,400 --> 00:16:42,540
+respiratory tract infection درسنا في ال micro
+
+224
+00:16:42,540 --> 00:16:45,550
+biology يا بناتStaphylococcus pneumonia درسنا
+
+225
+00:16:45,550 --> 00:16:47,790
+Mycoplasma pneumonia درسنا Klebsiella pneumonia
+
+226
+00:16:47,790 --> 00:16:50,170
+درسنا Hemophilus influenza Staphylococcus
+
+227
+00:16:50,170 --> 00:16:55,210
+pneumonia كلها أمراض بتسبب ال pneumonia لكن مين
+
+228
+00:16:55,210 --> 00:17:00,430
+أكثر مسبب ل pneumonia هي ال influenza هي المسبب
+
+229
+00:17:00,430 --> 00:17:04,510
+الأكبر لزيارة الطبيب ل pneumonia هي المسبب الأكبر
+
+230
+00:17:04,510 --> 00:17:08,750
+لل hospitalization للمبيت في المستشفى بسبب ايه ال
+
+231
+00:17:08,750 --> 00:17:14,160
+pneumonia إذا ال influenza وإن بدت لناخفيفة مبدأت
+
+232
+00:17:14,160 --> 00:17:20,020
+لنا مش خطيرة هنسمع أرقام كمان شوية و نسب هتخليكوا
+
+233
+00:17:20,020 --> 00:17:24,960
+تعيدوا النظر في موضوع ال influenza و أول رقم أنه
+
+234
+00:17:24,960 --> 00:17:30,640
+في ال 1918 أو ما يعرف بيه ال influenza الإسبانية
+
+235
+00:17:30,640 --> 00:17:36,170
+Spanish Fluطلعوا الأرقام اللي بنحكيها أو الوصف
+
+236
+00:17:36,170 --> 00:17:41,110
+للأرقام more American died than in world war one
+
+237
+00:17:41,110 --> 00:17:45,030
+world war one world war two the Korean war and the
+
+238
+00:17:45,030 --> 00:17:49,560
+Vietnamese war combinedاللي ماته بسبب هذه ال
+
+239
+00:17:49,560 --> 00:17:53,620
+influenza كان عددهم أكبر من اللي ماته في الحرب
+
+240
+00:17:53,620 --> 00:17:56,760
+العالمية الأولى والثانية والحرب الكورية والحرب
+
+241
+00:17:56,760 --> 00:18:02,160
+الويتنامي رقم مهول من الموتى قدر عدل الوفيات في
+
+242
+00:18:02,160 --> 00:18:06,440
+العالم من هذه ال influenza ب 40 إلى 50 مليون إنسان
+
+243
+00:18:06,440 --> 00:18:11,780
+وفي 1918 40 إلى 50 مليون إنسان هو رقم كبير جدا
+
+244
+00:18:11,780 --> 00:18:16,440
+بالنسبة لتداب السكان في العالمفبالتالي ال
+
+245
+00:18:16,440 --> 00:18:22,780
+influenza قد تحدث أوبئة خطيرة للغاية و ما نراه
+
+246
+00:18:22,780 --> 00:18:29,800
+اليوم منخواص لهذه الفيروسات يعني يجعل الخشية دائما
+
+247
+00:18:29,800 --> 00:18:34,800
+من انه يتولد لدينا سلالة بنسميها highly pathogenic
+
+248
+00:18:34,800 --> 00:18:38,400
+influenza virus كلمة highly pathogenic يعني
+
+249
+00:18:38,400 --> 00:18:43,800
+إمراضها أو إمراضيتها عالية شراستها عالية نسبة
+
+250
+00:18:43,800 --> 00:18:47,700
+القتل فيها عالية فلنتكلم عن نسبة القتل في ال
+
+251
+00:18:47,700 --> 00:18:52,020
+influenza العادىهل تعلمون إن ال influenza الموسمية
+
+252
+00:18:52,020 --> 00:18:56,440
+نسبة الوفيات فيها قد تصل إلى 5%؟ طبعا أنتم لم
+
+253
+00:18:56,440 --> 00:19:00,560
+تسمعوا من قبل إن فلان مات من ال influenza لكن كما
+
+254
+00:19:00,560 --> 00:19:05,400
+ذكرت لكم في البلدان اللي ارتفع فيها ال life
+
+255
+00:19:05,400 --> 00:19:10,720
+expectancy اللي هو عمر الإنسان صار 80 و 85 ووصل 90
+
+256
+00:19:10,720 --> 00:19:16,740
+في اليابان ال life expectancyهدولة الناس فئة يعني
+
+257
+00:19:16,740 --> 00:19:22,240
+الكبار السن منعتهم ضعيفة فإذا أصيبوا ب influenza
+
+258
+00:19:22,240 --> 00:19:24,960
+قد تكون devastating عليهم فبتاع اللي هم هدولة
+
+259
+00:19:24,960 --> 00:19:29,260
+بنحسبه من ضمن مين؟ من ضمن الخمسة بالمئة في
+
+260
+00:19:29,260 --> 00:19:34,740
+influenza الطيور أو الخنازير عفوا كان أكثر فئة
+
+261
+00:19:34,740 --> 00:19:42,200
+معرضة هم الحوامل، نساء الحواملفي influenza الطيور
+
+262
+00:19:42,200 --> 00:19:45,680
+لحظة اننا نتكلم على أسماء مختلفة من ال influenza
+
+263
+00:19:45,680 --> 00:19:51,280
+قد يكون ال target أو الأكتر عرضة للإصابة أو
+
+264
+00:19:51,280 --> 00:19:54,100
+للوفيات مختلفة عن ال influenza أخرى
+
+265
+00:19:56,230 --> 00:19:58,530
+الإنفلوانزة الخنازية بالنسبة للوفيات فيها كانت أقل
+
+266
+00:19:58,530 --> 00:20:02,930
+من point five أقل من نص بالمائة أقل من نص بالمائة
+
+267
+00:20:02,930 --> 00:20:08,450
+إذا نتكلم عن سلالات مختلفة مختلفة من أي ناحية من
+
+268
+00:20:08,450 --> 00:20:14,370
+قدرتها على الانتقال من شخص إلى شخص و في قدرتها على
+
+269
+00:20:14,370 --> 00:20:19,270
+القتل يعني مثلا ال avian influenza اللي هي
+
+270
+00:20:19,270 --> 00:20:25,030
+انفلوانزة الطيورحوالي أكتر من ستين بالمائة من
+
+271
+00:20:25,030 --> 00:20:30,030
+الذين أصيبوا ماتوا يبقى نسبة قتل إيه؟ غالية لكن ال
+
+272
+00:20:30,030 --> 00:20:34,210
+transmission تبعها ضعيف كيف يعني ال transmission؟
+
+273
+00:20:34,210 --> 00:20:38,930
+كل اللي أصيبوا بال avian influenza كان لابد أن
+
+274
+00:20:38,930 --> 00:20:41,930
+يحتكوا مع الدواجن المصابة يعني مافيش انتقال من
+
+275
+00:20:41,930 --> 00:20:46,350
+الإنسان لإنسان أو الانتقال من الإنسان لإنسان كان
+
+276
+00:20:46,350 --> 00:20:53,920
+يعني undocumented مش موطق بشكل جيدبينما ال
+
+277
+00:20:53,920 --> 00:20:58,040
+influenza الخاصة بالخنازير أسارت معظم سكان العالم
+
+278
+00:20:58,040 --> 00:21:03,600
+يعني أمريكا بعد اتنين مليون إصابة بطل يؤدوا وصلت
+
+279
+00:21:03,600 --> 00:21:09,680
+صورة كيف؟ ان في سلالات سهل تنتشر وأقل إمراضية
+
+280
+00:21:09,680 --> 00:21:15,680
+وسلالات صعب تنتشر لكن إمراضيتها عالية جدا الخشية
+
+281
+00:21:15,680 --> 00:21:21,150
+من تزاوجهتيم السلالتين لإخراج سلالة تمتلك الصفتين
+
+282
+00:21:21,150 --> 00:21:26,890
+صناعة انتشار و نسبة قتل عالية وهذا الذي حدث في ال
+
+283
+00:21:26,890 --> 00:21:31,790
+influenza الإسبانية عام 1918 كان highly pathogenic
+
+284
+00:21:31,790 --> 00:21:35,090
+strain و بيقدر يعمل transmission من إنسان إلى
+
+285
+00:21:35,090 --> 00:21:36,230
+إنسان
+
+286
+00:21:39,010 --> 00:21:43,090
+الانفلوانزا B قولنا does not cause pandemics and
+
+287
+00:21:43,090 --> 00:21:46,330
+the major outbreak caused by this virus does not
+
+288
+00:21:46,330 --> 00:21:50,090
+occur as often as those caused by influenza A يعني
+
+289
+00:21:50,090 --> 00:21:54,210
+حتى لما بعمل outbreak انفلوانزا B مش بنفس الكثرة و
+
+290
+00:21:54,210 --> 00:21:58,050
+بنفس الفعالي اللي بعملها انفلوانزا A يعني بالترتيب
+
+291
+00:21:58,050 --> 00:22:02,790
+A is the most dangerous يليها B و بعدين يليها
+
+292
+00:22:02,790 --> 00:22:07,240
+الأخيرة Cطب طلع الرقم عشان انتوا تصدقوا انه .. انه
+
+293
+00:22:07,240 --> 00:22:10,880
+خمسة بالمائة من حالة ال influenza ستة و تلاتين الف
+
+294
+00:22:10,880 --> 00:22:14,680
+حالة وفاة في الولايات المتحدة تؤذى للإصابة بال
+
+295
+00:22:14,680 --> 00:22:20,480
+influenza إذن بالفعل احنا بنتكلم عن مرض نسبته فيه
+
+296
+00:22:20,480 --> 00:22:27,440
+عالي جدا و يسهل انتقاله بين الناس في ال 1947،
+
+297
+00:22:27,440 --> 00:22:32,540
+1957، 1968، 1977، 1987 طلعوا على اللي بانيني انا
+
+298
+00:22:32,540 --> 00:22:39,380
+السنةمن 47 ل 57 كده؟ 10 سنوات او 11 سنة من 57 ل 68
+
+299
+00:22:39,380 --> 00:22:44,660
+حوالي 11 سنة او 12 سنة من 68 ل 77 برضه نفس الجثة
+
+300
+00:22:44,660 --> 00:22:51,140
+يعني نقدر نقول ان كل بمعدل كل 10 سنوات بيظهر لدينا
+
+301
+00:22:51,140 --> 00:22:54,740
+سلالة جديدة و انا بقول ان كل يوم بيظهر لنا سلالة
+
+302
+00:22:54,740 --> 00:22:58,980
+جديدة لكن سلالات ناجحة من وجهة طرف الفيروس و بتسبب
+
+303
+00:22:58,980 --> 00:23:02,640
+امراض الإنسان تقريبا كل 10 سنوات بيظهر لنا سلالة
+
+304
+00:23:02,640 --> 00:23:06,530
+جديدةوهذا كتير مهمة العمود التاني ايضا ليه كلها
+
+305
+00:23:06,530 --> 00:23:10,130
+همية لانه بتكلم عن hemagglutination او
+
+306
+00:23:10,130 --> 00:23:17,910
+hemagglutinin و neuroaminidase H1N1 H2N2 H3N2 H3
+
+307
+00:23:17,910 --> 00:23:23,930
+وH1 وH3N2
+
+308
+00:23:23,930 --> 00:23:29,570
+يعني فيه strains مختلفة تعالوا نطلع علىكيف بيسمو
+
+309
+00:23:29,570 --> 00:23:34,290
+ال prototype strain كانوا؟ A طبعا هذا مؤشر على ان
+
+310
+00:23:34,290 --> 00:23:38,610
+ال influenza strain هي من نوع A، مكان الانتشار كان
+
+311
+00:23:38,610 --> 00:23:43,810
+في Singapore، Singapore يعني، سنة كدهش؟ سبعة و
+
+312
+00:23:43,810 --> 00:23:47,810
+خمسين، هيك كانوا بيسمو المسمية تبع ال virus يعني
+
+313
+00:23:50,830 --> 00:23:53,690
+كما ذكرناها الآن الكلام اللي بنقوله بإعادة لكن
+
+314
+00:23:53,690 --> 00:23:57,330
+تأكيد على المعلومات اللي ذكرناها انه ال influenza
+
+315
+00:23:57,330 --> 00:24:01,090
+virus بتكون من a segmented single strand RNA جينوم
+
+316
+00:24:01,090 --> 00:24:04,630
+helical nucleocapsid outer lipoprotein envelope
+
+317
+00:24:04,630 --> 00:24:08,810
+وبيحتوى على RNA dependent RNA polymerase وبالتالي
+
+318
+00:24:08,810 --> 00:24:12,710
+الجينوم تبقى ورنا عنه ما قالوا ايه؟ non-infectious
+
+319
+00:24:12,710 --> 00:24:17,540
+يعني غير موادالـ Envelope يحتوى على Neuroaminidase
+
+320
+00:24:17,540 --> 00:24:20,980
+و Hemagglutinin الإنفلوانزا فيروس تقع الأهل
+
+321
+00:24:20,980 --> 00:24:26,580
+الأرقام 16 Antigenically distinct Hemagglutinin
+
+322
+00:24:26,580 --> 00:24:31,620
+يعني من 1 ل 16 H و 9 Antigenically distinct type
+
+323
+00:24:31,620 --> 00:24:35,960
+Neuroaminidase يعني من 1 ل 9 N يبقى لو تخيلنا
+
+324
+00:24:35,960 --> 00:24:39,140
+تبديل و توافق بينهم هيطلع عندنا عدد كبير جدا من
+
+325
+00:24:39,140 --> 00:24:42,300
+السليلات اللي .. اللي .. اللي .. اللي خاصة ب
+
+326
+00:24:42,300 --> 00:24:46,930
+Influenza A virusالـ function الآن للـ
+
+327
+00:24:46,930 --> 00:24:49,670
+hemagglutinin والـ neuroamidase حان موعدها أن
+
+328
+00:24:49,670 --> 00:24:54,730
+نعرفها الـ hemagglutinin هو المسئول عن الإرتباط
+
+329
+00:24:54,730 --> 00:24:59,730
+بالـ cell surface يعني خليانة إلها receptor للـ
+
+330
+00:24:59,730 --> 00:25:03,770
+hemagglutinin طبعا صمي hemagglutinin لأنه من ال ..
+
+331
+00:25:03,770 --> 00:25:06,690
+في المعمل لجانب المعمل agglutination لمين؟ لرد بلد
+
+332
+00:25:06,690 --> 00:25:10,870
+cell إذن في بداية ال infection من المسئول؟ الـ
+
+333
+00:25:10,870 --> 00:25:15,310
+hemagglutinin لو كوّننا antibodies ضدهبتعملنا
+
+334
+00:25:15,310 --> 00:25:18,770
+protection يبقى neutralizing antibody against
+
+335
+00:25:18,770 --> 00:25:22,730
+hemagglutinin هي اللي بتوفر حماية لمن؟ او ضد الانف
+
+336
+00:25:22,730 --> 00:25:28,630
+لوانزا طيب الـ Neuraminidase وين بيشتغل؟ فاكرنا
+
+337
+00:25:28,630 --> 00:25:32,330
+لما كنا نقول احنا ان بعض الفيروسات و هي طالع بتاخد
+
+338
+00:25:32,330 --> 00:25:36,850
+ال envelope ايش سبب عملية هذه؟ budding ولا لا؟
+
+339
+00:25:36,850 --> 00:25:40,970
+budding تبرا الانف ال budding مش لازم يكون فيه
+
+340
+00:25:40,970 --> 00:25:46,540
+تخلصللفيروس من ال membrane يعني هو أخد جزء من ال
+
+341
+00:25:46,540 --> 00:25:50,560
+membrane لازم ينجس و يطلع مين اللي بيجرسه في هذه
+
+342
+00:25:50,560 --> 00:25:55,240
+الحالة ال neuroaminidase إذا الأن إذا أنا أخدت
+
+343
+00:25:55,240 --> 00:25:59,840
+مضاد لل neuroaminidase إيش هيصير في الفيروس؟ هيبقى
+
+344
+00:25:59,840 --> 00:26:03,340
+ملتصق على الخلية اللي سبب .. اللي كان هو اتكون
+
+345
+00:26:03,340 --> 00:26:07,190
+فيهاإذا دلّا ملزج فيها، مش هيارة ال infection
+
+346
+00:26:07,190 --> 00:26:11,510
+لمين؟ لخلايا تانية، إذا أنا هيك بكون بوقفة انتشار
+
+347
+00:26:11,510 --> 00:26:15,710
+ال virus داخل هذا الإنسان، إذا ال neuroaminidase
+
+348
+00:26:15,710 --> 00:26:19,830
+أشتغل بالأول أو بالآخر؟ بالآخر، ال hemagglutinin
+
+349
+00:26:19,830 --> 00:26:23,650
+هو اللي دخل الفيروس، وال neuroaminidase هو اللي
+
+350
+00:26:23,650 --> 00:26:28,330
+طلّع الفيروس، لكن في وظيفة تانية يا بنات لل
+
+351
+00:26:28,330 --> 00:26:31,670
+neuroaminidase، يعتقد إنها مهمة جدا في بداية ال
+
+352
+00:26:31,670 --> 00:26:34,790
+infectionنحن نعرف أن الميوكاس بيكون مغطي الـ
+
+353
+00:26:34,790 --> 00:26:38,210
+Epithelial cells، الآن الميوكاس أو الميوسين هذا
+
+354
+00:26:38,210 --> 00:26:42,390
+تمامًا، هذا بيعمل عازل بين الخلايا وبين الفيروس،
+
+355
+00:26:42,390 --> 00:26:45,550
+فالـ Neuroaminidase واجهته أنه له قدرة على أن يحلل
+
+356
+00:26:45,550 --> 00:26:50,320
+الميوسينبما انه بيحلل الميوسين فهو بيعمل exposure
+
+357
+00:26:50,320 --> 00:26:55,020
+لمن؟ للـepithelial cells وبالتالي برضه بساعة عملية
+
+358
+00:26:55,020 --> 00:26:58,480
+الارتباط، إذا ان هو الودور في بداية ال infection و
+
+359
+00:26:58,480 --> 00:27:02,900
+الودور في نهاية ال infection، بس الهيم أجلوتنين
+
+360
+00:27:02,900 --> 00:27:05,580
+دوره في الارتباط ل ال virus
+
+361
+00:27:12,160 --> 00:27:16,080
+فقرة الأخيرة الانفلوانزا فيروس especially
+
+362
+00:27:16,080 --> 00:27:19,380
+influenza A virus showed changes in the
+
+363
+00:27:19,380 --> 00:27:22,500
+antigenicity of their hemagglutinin and
+
+364
+00:27:22,500 --> 00:27:26,520
+neuroaminidase. This property contribute to their
+
+365
+00:27:26,520 --> 00:27:30,130
+capacity to cause devastating worldwideepidemics
+
+366
+00:27:30,130 --> 00:27:36,450
+كلمة devastating يعني مدمرة مؤثرة طبعا فقدرتها على
+
+367
+00:27:36,450 --> 00:27:40,910
+تغيير ال antigenات تبعتها هي اللي مخليها باستمرار
+
+368
+00:27:40,910 --> 00:27:47,320
+تكون أوبئة عالمية بشكل مستمركلام مره تذكير، عندنا
+
+369
+00:27:47,320 --> 00:27:51,000
+Hemagglutinin و عندنا Neuroaminidase و عندنا من
+
+370
+00:27:51,000 --> 00:27:56,740
+هنا Polymerase، قلنا اللي هو الـ RNA dependent RNA
+
+371
+00:27:56,740 --> 00:27:59,320
+Polymerase، طبعا في عدد البروتينات، هتتكلم عنها
+
+372
+00:27:59,320 --> 00:28:05,760
+لاحقا ان شاء اللهأحنا ميزنا الانفلوانزا من زمان
+
+373
+00:28:05,760 --> 00:28:12,160
+بقدرتها على تغيير انتجيناتها، الآن حان الأوان أن
+
+374
+00:28:12,160 --> 00:28:19,340
+نعرف كيف لهذه الفيروسات أن تغير انتجيناتهايعني
+
+375
+00:28:19,340 --> 00:28:23,080
+تعبيرين مهمين antigenic shift وكلمة shift معناها
+
+376
+00:28:23,080 --> 00:28:27,620
+تغيير جذري major change و antigenic drift تغيير
+
+377
+00:28:27,620 --> 00:28:33,100
+minor minor يعني بقيل او قليل لا يعني انه minor
+
+378
+00:28:33,100 --> 00:28:37,920
+انه سيء انه مش كويس لل virus بالعكس ال minor هو
+
+379
+00:28:37,920 --> 00:28:43,960
+اللي مخليه ماشيباستمرار و بسببنا أمراض مرارا و
+
+380
+00:28:43,960 --> 00:28:47,180
+تكرارا يعني أنا لما أصاب بال influenza تلات أربع
+
+381
+00:28:47,180 --> 00:28:51,300
+مرات في السنة من نفس السلالة H1N1 على سبيل المثال
+
+382
+00:28:51,300 --> 00:28:58,960
+ليش أصاب أربع مرات انا ب H1N1 لأن ال H1 ماصارش H2
+
+383
+00:28:58,960 --> 00:29:04,110
+بله H1 لكن صار في تغيير طفيفهذا التغيير الطفيف
+
+384
+00:29:04,110 --> 00:29:09,330
+برضه خدع جهاز المناعة تبعنا، إذن الـ H أفضل ال
+
+385
+00:29:09,330 --> 00:29:14,790
+shift و ال drift كلا هما إيه تأثير على أن الفيروس
+
+386
+00:29:14,790 --> 00:29:19,190
+يغير أنتجيناته بشكل مستمر، كيف بيصير أن تغيير
+
+387
+00:29:19,190 --> 00:29:25,070
+الانتجينات؟ ليش سهل في هذا الفيروس؟ لأنه segmented
+
+388
+00:29:25,070 --> 00:29:25,670
+genome
+
+389
+00:29:28,890 --> 00:29:34,090
+لو تخيلنا two distinct viruses، لاحظوا هذا اللون
+
+390
+00:29:34,090 --> 00:29:37,810
+تبعه أزرج، أزرج و هذا اللون أيش تبعه؟ أسود، كلا
+
+391
+00:29:37,810 --> 00:29:41,230
+هما عملوا infection at the same time in a single
+
+392
+00:29:41,230 --> 00:29:46,910
+cell، واحد جاي من خنزير أو من إنسان، واحد من طير،
+
+393
+00:29:46,910 --> 00:29:52,410
+وخدوا بالكوا، في سلالات الإنفلوانزا قد نجد سلالة
+
+394
+00:29:52,410 --> 00:29:56,850
+بتصيب الخنزير والحصان وما بتصيبش الإنسانوقد نجد
+
+395
+00:29:56,850 --> 00:30:00,410
+سوية لا بتصيب الإنسان والخنزير وما بتصيبش الحصان
+
+396
+00:30:00,410 --> 00:30:04,730
+تمام؟ ففي طبعا حسب نوع ال receptors اللي موجودة
+
+397
+00:30:04,730 --> 00:30:10,130
+على هذا ال virus الآن لو اتنين viruses from two
+
+398
+00:30:10,130 --> 00:30:14,170
+distinct hosts تمام؟ عملوا infection في common
+
+399
+00:30:14,170 --> 00:30:20,110
+host اللي هو الخنزير أكرمكم الله ككالة عادةالان
+
+400
+00:30:20,110 --> 00:30:23,810
+بدأ افترض طبعا تعرفين ان الفيروس اذا دخل خلية
+
+401
+00:30:23,810 --> 00:30:27,010
+بيعمل protection انه مايدخلهاش other viruses، بس
+
+402
+00:30:27,010 --> 00:30:30,290
+هذه المرة بدنا نفترض انهم دخلوا مع بعض بنفس الوجد،
+
+403
+00:30:30,290 --> 00:30:32,350
+دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا،
+
+404
+00:30:32,350 --> 00:30:33,490
+دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا،
+
+405
+00:30:33,490 --> 00:30:33,890
+دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا،
+
+406
+00:30:33,890 --> 00:30:34,050
+دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا، دخلوا،
+
+407
+00:30:34,050 --> 00:30:37,800
+دخلوا، دخلوا، دخلواوعند التكاثر في مرحلة بتعرفوها
+
+408
+00:30:37,800 --> 00:30:42,500
+كلكوا اسمة assembly and release ال assembly ايش ال
+
+409
+00:30:42,500 --> 00:30:46,600
+assembly؟ هو ان نقوم بوضع المادة الوراثية داخل
+
+410
+00:30:46,600 --> 00:30:50,560
+الكبسيط داخل الكبسيط الان انا بتكلم عن segments
+
+411
+00:30:50,560 --> 00:30:55,180
+تمام قطع الجينوم لكل واحد منهم احتمالية ان يصير
+
+412
+00:30:55,180 --> 00:31:00,160
+exchange بينهم بتكون عالية اذا صار exchange ل
+
+413
+00:31:00,160 --> 00:31:05,710
+segments بين two viruses هيطلع new virusمش
+
+414
+00:31:05,710 --> 00:31:09,570
+بالضرورة يا جماعة ان ال new virus يكون virus فعال
+
+415
+00:31:09,570 --> 00:31:15,170
+ممكن يكون inactive virus ومايشتغلش لكن كل فترة
+
+416
+00:31:15,170 --> 00:31:20,140
+وفترة واتذكروا الأسنوات اللي حكيناها مادةبيطلعنا
+
+417
+00:31:20,140 --> 00:31:23,840
+سلالة ناجح مش معناه الحكي ان السلالة .. السلالة
+
+418
+00:31:23,840 --> 00:31:27,940
+ظهرت كل عشر سنوات السلالة انتشرت بعد عشر سنوات
+
+419
+00:31:27,940 --> 00:31:32,840
+يعني ممكن تكون اتكونت كل خمس سنوات لكن احتاجت كمان
+
+420
+00:31:32,840 --> 00:31:37,300
+خمس سنوات عشان تقدر تنتشر او تنتقل من ال host اللي
+
+421
+00:31:37,300 --> 00:31:41,700
+كانت فيه ال other hosts ذكروا ال avian influenza
+
+422
+00:31:41,700 --> 00:31:46,540
+بتصيب الطيور وبتنتقل للإنسان إذا انتقلت للإنسان
+
+423
+00:31:46,540 --> 00:31:51,860
+ماتنتقلش من الإنسان إلى إنسانيبقى هذه سلالة ناجحة
+
+424
+00:31:51,860 --> 00:31:56,700
+و لا مش ناجحة .. ناجحة جزئيا .. ناجحة بإنها انتشرت
+
+425
+00:31:56,700 --> 00:32:00,760
+في الطيور .. انتوا عارفين في غزة وصلت هنا و قامت
+
+426
+00:32:00,760 --> 00:32:05,780
+السلطات بادام آلاف الدواجن و في بلدان ملايين
+
+427
+00:32:05,780 --> 00:32:10,420
+الدواجن او راجول مليارات الدواجن قعدمت في آسيا حتى
+
+428
+00:32:10,420 --> 00:32:14,080
+يمنع انتشار هذا المرض و ما زال المرض بلفلف في
+
+429
+00:32:14,080 --> 00:32:21,590
+العالم بحالات قليلةتبقى خطورة إنه يخرج سلالة تجمع
+
+430
+00:32:21,590 --> 00:32:25,530
+ما بين الـ swine انفلوانزا أو ال even انفلوانزا
+
+431
+00:32:25,530 --> 00:32:28,590
+احتمالية عالية جدا، هذه اللي عماليش بنسميها يا
+
+432
+00:32:28,590 --> 00:32:33,610
+جماعة reassortment، هذه اسمها reassortment وتؤدي
+
+433
+00:32:33,610 --> 00:32:38,710
+إلى antigenic shift وليس antigenic drift، ال drift
+
+434
+00:32:38,710 --> 00:32:41,690
+مش معناه هقولك لهم مرة تغيير طفيف، التغيير الطفيف
+
+435
+00:32:41,690 --> 00:32:45,830
+كيف يكون انها .. عن ال mutationعن الـ mutation مش
+
+436
+00:32:45,830 --> 00:32:51,130
+عن تبادل قطاع من الديانيم طيب احنا قلنا انه في
+
+437
+00:32:51,130 --> 00:32:54,410
+other proteins و وعدناكم نطلع عليهم two matrix
+
+438
+00:32:54,410 --> 00:33:03,500
+protein M1 و M2الـ M1 يقع بين الـ Internal
+
+439
+00:33:03,500 --> 00:33:08,660
+Nucleoprotein Segment and the Envelope ويعطي
+
+440
+00:33:08,660 --> 00:33:12,560
+تركيبية مباشرة و مضيفته تركيبية
+
+441
+00:33:27,920 --> 00:33:33,100
+Matrix protein forms an ion channel between the
+
+442
+00:33:33,100 --> 00:33:36,800
+interior of the virus and external environment،
+
+443
+00:33:36,800 --> 00:33:42,800
+وكأنه وكأني بالفيروس يريد أن يستشهر بالعالم
+
+444
+00:33:42,800 --> 00:33:47,180
+الخارجي حواله، تمام؟ من خلال ال ion channel، إذا
+
+445
+00:33:47,180 --> 00:33:51,160
+في protein تاني موجود برضه في نفس المكان، لكن عامل
+
+446
+00:33:51,160 --> 00:33:58,480
+كقناة ايوناتهذا البرامج الأيونية تلقى رولية أساسية
+
+447
+00:33:58,480 --> 00:34:03,800
+في إزالة مكونات الفيريون بعدما يدخل الصحراء يبجى
+
+448
+00:34:03,800 --> 00:34:08,480
+هو المسؤول عن إدخال بعض الأيونات إراكمها حتى يحول
+
+449
+00:34:08,480 --> 00:34:13,260
+الفيزيك اللي هو موجود جواها إلى أسد وبالتالي يسهر
+
+450
+00:34:13,260 --> 00:34:18,670
+عملية تفكيكاللي هي ال capsomers و لما تتفكك ال
+
+451
+00:34:18,670 --> 00:34:22,450
+capsomers هيطلق من المادة الوراثية أصلا ال
+
+452
+00:34:22,450 --> 00:34:27,350
+capsomers هي اللي مكونة ال capsid صح؟ الآن تحت ظرف
+
+453
+00:34:27,350 --> 00:34:31,770
+من acidity ال capsomers تتفكفك عن بعضها إذا
+
+454
+00:34:31,770 --> 00:34:35,210
+تتفكفكت عن بعضها المادة الوراثية تنطلق إلى داخل
+
+455
+00:34:35,210 --> 00:34:40,230
+اللي هو الخليل إذا matrix protein M1 و M2 الأولاني
+
+456
+00:34:40,230 --> 00:34:44,250
+provides structural integrity والتاني ion channel
+
+457
+00:34:46,980 --> 00:34:51,260
+الان ال influenza virus have both group specific
+
+458
+00:34:51,260 --> 00:34:53,960
+and type specific antigen، إيش يعني group
+
+459
+00:34:53,960 --> 00:34:59,920
+specific؟ يعني group A كلها إلها one single
+
+460
+00:34:59,920 --> 00:35:03,160
+antigen، common antigen، طب يا دي وقت الخير مدام
+
+461
+00:35:03,160 --> 00:35:06,860
+إلها one common antigen، لماذا لم نقم بإعداد
+
+462
+00:35:06,860 --> 00:35:11,360
+vaccine ضد هذا ال antigen؟ بحكي
+
+463
+00:35:14,080 --> 00:35:17,400
+مش منطقي إنه إذا كان فيه common antigen، إنه
+
+464
+00:35:17,400 --> 00:35:23,060
+نكوّلله antibody؟ طيب، إذا مافيش محاولة من طرفكم،
+
+465
+00:35:23,060 --> 00:35:28,970
+لازم نحاول من هناال common antigen ممتاز هدف ممتاز
+
+466
+00:35:28,970 --> 00:35:32,730
+لل vaccine لكن يا جماعة لازم لما يتكونله antibody
+
+467
+00:35:32,730 --> 00:35:36,030
+يكون ال antibody protective احنا بيقولون لمين ال
+
+468
+00:35:36,030 --> 00:35:40,330
+protective ال antibody؟ ضد الهيم أجلوتنين صح ولاء
+
+469
+00:35:40,330 --> 00:35:43,370
+و للأسف الهيم أجلوتنين مش common هو اللي فيه
+
+470
+00:35:43,370 --> 00:35:47,150
+variation أصلا هو اللي فيه variation لكن في أخبار
+
+471
+00:35:47,150 --> 00:35:51,810
+جديدة بتقول إن ال influenza virus قريبا سيكون هناك
+
+472
+00:35:51,810 --> 00:35:52,650
+vaccine
+
+473
+00:35:55,460 --> 00:36:01,600
+لأنهم لقوا انتجين common وفي نفس الوجد لو عملنا له
+
+474
+00:36:01,600 --> 00:36:05,020
+antibody بيكون protected، بإذن صفتها لازم يكون
+
+475
+00:36:05,020 --> 00:36:07,640
+common و لازم يكون ال antibody protect
+
+476
+00:36:10,830 --> 00:36:14,730
+هو يحتوي على كتب وكتب وكتب وكتب وكتب وكتب وكتب
+
+477
+00:36:14,730 --> 00:36:18,510
+وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب
+
+478
+00:36:18,510 --> 00:36:20,110
+وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب
+
+479
+00:36:20,110 --> 00:36:23,510
+وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب
+
+480
+00:36:23,510 --> 00:36:28,890
+وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكتب
+
+481
+00:36:28,890 --> 00:36:39,210
+وكتب وكتب وكتب وكتب وكتب وكتب وكتب وكت
+
+482
+00:36:39,380 --> 00:36:44,280
+N3 فاهمين؟ في ال influenza A، إذن هم influenza A
+
+483
+00:36:44,280 --> 00:36:47,900
+صحيح، لكن N1 و N2 و N3 مانا بتحكي إنه بيعملوه،
+
+484
+00:36:47,900 --> 00:36:51,580
+اللي هو بيسموهم type specific، إذن group specific
+
+485
+00:36:51,580 --> 00:36:56,200
+و type specific، كذلك الأمر بالنسبة للهم agglutin
+
+486
+00:36:58,020 --> 00:37:02,300
+وتكرار لنفس المعلومة بيقول ان antibody against the
+
+487
+00:37:02,300 --> 00:37:05,780
+heme agglutinin neutralizes the infectivity of the
+
+488
+00:37:05,780 --> 00:37:09,880
+virus يعني الفيروس will no longer be infective إذا
+
+489
+00:37:09,880 --> 00:37:13,680
+اتكوّن انتبادي لمن؟ للهيم أجلوتيني whereas
+
+490
+00:37:13,680 --> 00:37:17,500
+antibody against the group specific antigen which
+
+491
+00:37:17,500 --> 00:37:20,760
+is located internally in the virus will not
+
+492
+00:37:20,760 --> 00:37:25,800
+protect from that virus وصل الصورة أن الجروب للأسف
+
+493
+00:37:25,800 --> 00:37:28,520
+الجروب اللي هو commonمش الـ Protective الـ
+
+494
+00:37:28,520 --> 00:37:33,100
+Antibody الـ اليوم الأخيرة Antibody against the
+
+495
+00:37:33,100 --> 00:37:36,060
+Neuroaminidase does not neutralize infectivity
+
+496
+00:37:36,060 --> 00:37:38,140
+احنا نقول أن الـ Neuroaminidase هو اللي بيشتغل
+
+497
+00:37:38,140 --> 00:37:44,540
+بيشتغل في الآخر صح ولا لأ فهو لن يقوم بعملية اللي
+
+498
+00:37:44,540 --> 00:37:49,960
+جونا اللي هي ال neutralization لكن لو اتكلمنا عن
+
+499
+00:37:49,960 --> 00:37:54,100
+كيميكل بيعمل Inhibition للـ Neuroaminidaseتمام
+
+500
+00:37:54,100 --> 00:37:58,260
+كيميكال هذا بيبطل انتباطيش بيصير drug antiviral
+
+501
+00:37:58,260 --> 00:38:02,340
+drug against neuroaminidase وهناك مجموعة من ال
+
+502
+00:38:02,340 --> 00:38:06,440
+drugs بيسميها neuroaminidase inhibitors اللي منها
+
+503
+00:38:06,440 --> 00:38:11,340
+oseltamivir و xenamivir والتي اشتهرت او اشتهرت
+
+504
+00:38:11,340 --> 00:38:14,500
+فترة اللي هو انتشار الانفلوانزا الأخيرة اللي في ال
+
+505
+00:38:14,500 --> 00:38:17,540
+avian effluent المرة الجاية ان شاء الله بنكمل
+
+506
+00:38:17,540 --> 00:38:20,280
+الخصائص ترات اللي هو ال influenza virus
+
diff --git a/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/zONkYuOqbwo.srt b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/zONkYuOqbwo.srt
new file mode 100644
index 0000000000000000000000000000000000000000..c6d8ccc8256ea9e932f310c97f39b12d156aa2ec
--- /dev/null
+++ b/PL9fwy3NUQKwb5vTyRo7E6CT3NOdgtp47N/zONkYuOqbwo.srt
@@ -0,0 +1,1623 @@
+1
+00:00:20,910 --> 00:00:23,990
+بسم الله الرحمن الرحيم نكمل ما بدأنا به المحاضرة 
+
+2
+00:00:23,990 --> 00:00:28,390
+السابقة من DNA Non-Enveloped Viruses تذكيرا 
+
+3
+00:00:28,390 --> 00:00:32,510
+بالأسماء اللي احنا اتطرقنا لها و سنتطرق لها إن شاء 
+
+4
+00:00:32,510 --> 00:00:36,910
+الله، اتكلمنا بشكل موسع عن الـ adenovirus و عرفنا 
+
+5
+00:00:36,910 --> 00:00:41,770
+أنه فيها أكثر من أربعين صنف من الفيروسات و اتكلمنا 
+
+6
+00:00:41,770 --> 00:00:44,310
+عن الـ human papillomavirus لا أدري إن كملناها 
+
+7
+00:00:44,310 --> 00:00:48,010
+أكملناها أنتم هنا منها ولا لسه؟ طيب اللي هو الـ
+
+8
+00:00:48,010 --> 00:00:50,610
+papilloma virus يقول لنا أكثر أو على الأقل فيه هناك 
+
+9
+00:00:50,610 --> 00:00:56,030
+مائة سلالة من هذا الفيروس، واتحدثنا عن سلالات تصيب 
+
+10
+00:00:56,030 --> 00:01:00,570
+specific tissue فقلنا فيه skin warts وفيه genital 
+
+11
+00:01:00,570 --> 00:01:04,430
+warts وفيه warts كمان ممكن تصيب الفم و الـ 
+
+12
+00:01:04,430 --> 00:01:07,730
+respiratory tract و خاصة لما المولود يولد لأم 
+
+13
+00:01:07,730 --> 00:01:13,330
+مصابة بالـ genital اللي هو الـ papilloma virus و
+
+14
+00:01:13,330 --> 00:01:17,180
+الفيروس الأخير كان اللي هو الـ ParvoB19 اللي سميناها 
+
+15
+00:01:17,180 --> 00:01:20,880
+Slab Chick Syndrome ومررنا بشكل يعني مفصل عن الـ
+
+16
+00:01:20,880 --> 00:01:23,800
+adenovirus وقلنا هو هذا الفيروس هو الوحيد اللي له 
+
+17
+00:01:23,800 --> 00:01:30,320
+fiber proteins وشوفنا له فوائد كثيرة للفيروس منها 
+
+18
+00:01:30,320 --> 00:01:33,240
+أن هو الـ antigen منها هو الـ attachment site منها 
+
+19
+00:01:33,240 --> 00:01:36,520
+هو الـ agglutination وكمان في نفس الوقت لما عملنا 
+
+20
+00:01:36,520 --> 00:01:38,960
+له purification وحققناه بالخلايا لجنة أنه toxic 
+
+21
+00:01:38,960 --> 00:01:44,820
+لمن؟ للخلايا، اتكلمنا عن أمراض كثيرة الصحيح في الـ 
+
+22
+00:01:44,820 --> 00:01:48,660
+adenovirus وبعض الخصائص المهمة اللي أكثرها ركزت 
+
+23
+00:01:48,660 --> 00:01:53,500
+على اللي هو الـ fibers، اتكلمنا عن أنه بيعمل 
+
+24
+00:01:53,500 --> 00:01:57,060
+carcinoma أو sarcomas في الحيوانات لكن ده ما له 
+
+25
+00:01:57,060 --> 00:02:02,460
+carcinomas في الإنسان، وبينتقل ببعض الطرق أهمها الـ 
+
+26
+00:02:02,460 --> 00:02:04,700
+aerosols droplets و الثانية الفكرة الـ oral و 
+
+27
+00:02:04,700 --> 00:02:09,080
+الثالثة اللي هو direct inoculation واتكلمنا عن الـ 
+
+28
+00:02:09,080 --> 00:02:12,200
+strains جونا اللي برضه specific strains بتصيب 
+
+29
+00:02:12,200 --> 00:02:16,640
+specific areas أو tissues زي مثلا type 8 و 9 جونا 
+
+30
+00:02:16,640 --> 00:02:21,080
+بيعملوا keratoconductivitis 11 و 21 بيعملوا مثلا 
+
+31
+00:02:21,080 --> 00:02:25,960
+hemorrhagic cystitis الأخرى 
+
+32
+00:02:25,960 --> 00:02:30,440
+أيضا اتكلمنا أن هذا الفيروس دون عن المجموعة زمايلا 
+
+33
+00:02:30,440 --> 00:02:35,300
+من المجموعة بيعمل تنسي تشبه مين؟ جونا بالـ herpes 
+
+34
+00:02:35,300 --> 00:02:36,340
+virus family 
+
+35
+00:02:40,110 --> 00:02:42,530
+الحاجة اللي بالنسبة لـ الـ .. الـ .. الـ laboratory 
+
+36
+00:02:42,530 --> 00:02:45,250
+diagnosis كان ممكن إنه نكشف عن الفيروس بالـ cell 
+
+37
+00:02:45,250 --> 00:02:48,770
+culture أو من خلال الـ serology و اتكلمنا عن four 
+
+38
+00:02:48,770 --> 00:02:52,090
+fold increase in antibody titer و الـ treatment و 
+
+39
+00:02:52,090 --> 00:02:55,530
+كنا مافيش antiviral therapy و بالنسبة للـ 
+
+40
+00:02:55,530 --> 00:02:57,850
+prevention كان فيه إنه vaccine لكن هذا الـ vaccine 
+
+41
+00:02:57,850 --> 00:03:02,870
+فقط للملتاري و الـ .. الـ .. الـ .. الـ ذكرنا ثلاث 
+
+42
+00:03:02,870 --> 00:03:05,390
+أصناف مهمة اللي بالسبب الـ respiratory رمضان أربعة 
+
+43
+00:03:05,390 --> 00:03:09,660
+و سبعة و واحد و عشرين، لكن بنعطيهم ككبسولات قلنا 
+
+44
+00:03:09,660 --> 00:03:14,560
+Enteric-coated و Separately ما بنعطيهم مش مع بعض و 
+
+45
+00:03:14,560 --> 00:03:17,800
+إنما كل واحد على حده، وبدا أنا في الحديث عن الـ 
+
+46
+00:03:17,800 --> 00:03:20,940
+papillomavirus وشوفنا إنه بالـ papillomavirus أيضا 
+
+47
+00:03:20,940 --> 00:03:25,460
+specific serotypes can cause specific infection في 
+
+48
+00:03:25,460 --> 00:03:31,190
+skin warts و في genital warts، بالنسبة لدورهم في الـ 
+
+49
+00:03:31,190 --> 00:03:35,330
+carcinogenesis حددنا بالـ E6 و E7 اللي هما سميناهم 
+
+50
+00:03:35,330 --> 00:03:39,070
+early genes early 6 و early 7 اللي هما الـ genes 
+
+51
+00:03:39,070 --> 00:03:44,290
+وقلنا إن الـ early genes هذه هي المسؤولة عن 
+
+52
+00:03:44,290 --> 00:03:51,740
+الارتباط بالـ Retinoplastoma Protein أو الـ B53 
+
+53
+00:03:51,740 --> 00:03:55,560
+Protein، هذا الارتباط خدوا بالكم هو أساس الـ 
+
+54
+00:03:55,560 --> 00:04:00,620
+Carcinogenesis، ليش؟ لأن نفس السلالات الأخرى فيها 
+
+55
+00:04:00,620 --> 00:04:07,230
+E6 و E7، لكنها لا بتسبب الـ Cancer، فكيف نفسر إحداث 
+
+56
+00:04:07,230 --> 00:04:10,790
+بعض السلالات للكانسر و السلالات الأخرى لا تسبب 
+
+57
+00:04:10,790 --> 00:04:15,310
+كانسر؟ و أيضا لأن الـ E6 وE7 في اللي بيسببوا كانسر، 
+
+58
+00:04:15,310 --> 00:04:19,850
+الارتباط بتاعهم بالـ B53 ورتنو بلاستومة بروتين 
+
+59
+00:04:19,850 --> 00:04:25,670
+أقوى أضعاف من الـ other viruses و بالتالي الارتباط 
+
+60
+00:04:25,670 --> 00:04:29,890
+القوي هو اللي كان يعني العلامة الفارقة ما بين إنه 
+
+61
+00:04:29,890 --> 00:04:31,990
+يسير فيه cancer أو ما يسيرش فيه cancer 
+
+62
+00:04:42,500 --> 00:04:46,940
+أعتقد أننا شفنا هذه الصورة 
+
+63
+00:04:46,940 --> 00:04:49,920
+هي ده اللي مشروحتها قبل قليل، الـ clinical finding 
+
+64
+00:04:49,920 --> 00:04:54,380
+أو الـ diagnosis لـ الـ .. الـ .. الـ .. الـ disease is 
+
+65
+00:04:54,380 --> 00:04:57,500
+usually made clinically يعني الـ ورث اللي هي 
+
+66
+00:04:57,500 --> 00:05:02,360
+الثقليل سواء كانت skin أو كانت genital كلاهما 
+
+67
+00:05:02,360 --> 00:05:05,800
+clinically distinct يعني الطبيب بيشخصهم بكل سهولة 
+
+68
+00:05:05,800 --> 00:05:12,900
+و يسر، و الـ papillomas قلنا عنها أصلا أي نوع من الـ 
+
+69
+00:05:12,900 --> 00:05:15,820
+papilloma بيكون specific لـ serotype محدد، مثلا 
+
+70
+00:05:15,820 --> 00:05:19,260
+قلنا لـ skin و لـ planter، لـ planter إذا بتسمع 
+
+71
+00:05:19,260 --> 00:05:23,980
+بمصطلح مسامير، المسامير اللي بتطلع في الرجل مثل 
+
+72
+00:05:23,980 --> 00:05:31,700
+مثلا مثلا مثلا مثلا مثلا مثلا مثلا 
+
+73
+00:05:31,700 --> 00:05:45,940
+مثلا مثلا 
+
+74
+00:05:45,940 --> 00:05:49,440
+مثلا مثلا مثلا مثلا مثلا مثلا مثلا 
+
+75
+00:05:49,440 --> 00:05:49,600
+مثلا مثلا مثلا مثلا مثلا مثلا مثلا مثلا مثلا 
+
+76
+00:05:49,600 --> 00:05:49,720
+مثلا مثلا مثلا مثلا مثلا مثلا مثلا مثلا مثلا 
+
+77
+00:05:50,490 --> 00:05:55,850
+Papillomas are caused by HPV1 through HPV4 يعني من 
+
+78
+00:05:55,850 --> 00:05:59,770
+واحد إلى أربعة من واحد إلى أربعة بينما الـ genital 
+
+79
+00:05:59,770 --> 00:06:04,590
+warts اللي إيه اسم تاني كونديلوماتا أكيوميناتا تمام 
+
+80
+00:06:04,590 --> 00:06:10,710
+كونديلوماتا أكيوميناتا are caused by HPV6 و HPV11 
+
+81
+00:06:10,710 --> 00:06:14,170
+HPV6 
+
+82
+00:06:14,170 --> 00:06:21,220
+و HPV11 لو كانوا هم اللي عاملين genital warts و الأم 
+
+83
+00:06:21,220 --> 00:06:27,190
+الأم الحامل عاملة delivery صار عندها حياة ولادة 
+
+84
+00:06:27,190 --> 00:06:31,710
+الطفل هيمر عبر قناة الولادة و هيأخذ معها الفيروس 
+
+85
+00:06:31,710 --> 00:06:35,790
+الآن هذه كانت عاملة genital للأم genital tract 
+
+86
+00:06:35,790 --> 00:06:39,670
+infection للأم بس المولود إيش هيصير عنده؟ هيصير 
+
+87
+00:06:39,670 --> 00:06:43,990
+عنده respiratory tract papillomas تخيلوا الثقاليل 
+
+88
+00:06:43,990 --> 00:06:47,450
+هتكون موجودة في الـ respiratory tract ممكن تكون 
+
+89
+00:06:47,450 --> 00:06:51,370
+برضه في الفم أو الـ laryngeal papillomas 
+
+90
+00:06:54,890 --> 00:06:59,610
+أخطر مرض ممكن نتخيله بالنسبة للـ papilloma هو إن 
+
+91
+00:06:59,610 --> 00:07:03,070
+يكون فيه carcinoma of the uterine و للـ cervix و الـ 
+
+92
+00:07:03,070 --> 00:07:08,030
+penis and anus، هذه الأماكن اللي ممكن يتصاب 
+
+93
+00:07:08,030 --> 00:07:13,430
+بيكون فيها بالـ cancer من خلال الـ HPV و معظمها are 
+
+94
+00:07:13,430 --> 00:07:18,290
+associated with HPV 16 and 18، أيضا يجب أن يخدوا 
+
+95
+00:07:18,290 --> 00:07:24,450
+بالكم 6 و 11 و 16 و 18 كده صاروا؟ أربع سلالات 
+
+96
+00:07:24,450 --> 00:07:31,050
+اتذكرهم كويس 16 و 18 و 6 و 11 إيش العامل المشترك 
+
+97
+00:07:31,050 --> 00:07:35,750
+بينهم؟ Genital tract infection هدول هم الـ target 
+
+98
+00:07:35,750 --> 00:07:39,170
+تبعنا في الـ vaccination هم الـ target تبعنا بالـ 
+
+99
+00:07:39,170 --> 00:07:44,190
+vaccination فيها اسمه Occult Premalignant Lesions 
+
+100
+00:07:48,650 --> 00:07:55,710
+الليجن لسه ما صار Cancer، كيف بيعرفوا إنه ممكن هذا 
+
+101
+00:07:55,710 --> 00:08:00,250
+يصير cancer أو ما يصيرش cancer؟ بيمسحه الـ legion's 
+
+102
+00:08:00,250 --> 00:08:06,550
+acetic acid خل تمام، حتى بيعلموا الناس بالعامة في 
+
+103
+00:08:06,550 --> 00:08:09,210
+البيوت إنهم يعملوا هذا الفحص بالبيت، بيحط جطمة بيحط 
+
+104
+00:08:09,210 --> 00:08:12,910
+فيها خل و بيحطها على المناطق الجنسية المصابة، إذا 
+
+105
+00:08:12,910 --> 00:08:17,470
+صار فيه ابيضاض للمنطقة فهذا يعتبر pre malignant وهذا 
+
+106
+00:08:17,470 --> 00:08:22,460
+الشخص يعني most likely to develop cancer، most 
+
+107
+00:08:22,460 --> 00:08:26,740
+likely أما إذا بقي اللون كما هو فبالتالي هذا مش 
+
+108
+00:08:26,740 --> 00:08:32,040
+pre malignant lesions، الـ lab diagnosed احنا فيه 
+
+109
+00:08:32,040 --> 00:08:35,980
+سياق حديثنا تحدثنا عن koilocytes، الـ koilocytes 
+
+110
+00:08:35,980 --> 00:08:40,260
+عبارة عن epithelial cells صار فيها distinct 
+
+111
+00:08:40,260 --> 00:08:44,380
+vacuole زي الصورة الموجودة عنها 
+
+112
+00:08:48,520 --> 00:08:52,320
+يبقى الـ diagnosis is made خلينا نقول 
+
+113
+00:08:52,320 --> 00:08:55,520
+microscopically زي ما قلنا negribody و زي ما 
+
+114
+00:08:55,520 --> 00:08:59,700
+قلنا owl's eye هنتكلم عن هنا koilocytes اللي في 
+
+115
+00:08:59,700 --> 00:09:04,540
+الـ lesions اللي موجودة في الـ HPV، الفحص الثاني اللي 
+
+116
+00:09:04,540 --> 00:09:09,700
+هو الـ HPV Alpha الـ DNA Hybridization Test يعني 
+
+117
+00:09:09,700 --> 00:09:12,780
+بمعنى آخر Molecular Techniques، الـ Molecular 
+
+118
+00:09:12,780 --> 00:09:16,420
+Techniques اتكلمنا عليها مرارا وتكرارا إنها الآن 
+
+119
+00:09:16,420 --> 00:09:19,700
+هي hallmark في الـ diagnosis للـ viral infection 
+
+120
+00:09:19,700 --> 00:09:24,000
+و احنا هنا في غزة إذا عرضنا أن نتطور بمجال 
+
+121
+00:09:24,000 --> 00:09:30,200
+الفيروسات لابد لنا أن نبدأ جديا بجلب الفحوصات 
+
+122
+00:09:30,200 --> 00:09:34,700
+اللازمة لمعظم أنواع الفيروسات التي لا يُسأل عنها 
+
+123
+00:09:37,880 --> 00:09:43,880
+بشأن تطوير المجال، واتحدثنا عن أن كثير من الأمراض 
+
+124
+00:09:43,880 --> 00:09:48,660
+المعقدة التي لا يقدر عليها التشخيص تماما هنا بسبب .. 
+
+125
+00:09:48,660 --> 00:09:54,740
+بسبب مش عدم توفر الإمكانات بسبب عدم الرغبة يعني 
+
+126
+00:09:54,740 --> 00:09:58,180
+بالدرجة الأولى وليس بسبب أن التكلفة عالية لأن
+
+127
+00:09:58,180 --> 00:10:01,620
+التكلفة أصبحت في متناول اليد زيها زي أي فحوصات
+
+128
+00:10:01,620 --> 00:10:05,400
+أخرى يعني إحنا نشتري السيرولوجي 500 دولار 600
+
+129
+00:10:05,400 --> 00:10:09,360
+دولار 1000 دولار بعض الأحيان وحتى الـ PCR كذلك الأمر
+
+130
+00:10:09,360 --> 00:10:12,780
+يعني ما فيش فرق كبير بين هذه الفحوصات وبالتالي
+
+131
+00:10:12,780 --> 00:10:17,920
+لابد أن نتيح بعضًا من هذه الفحوصات إذا عرضنا أن 
+
+132
+00:10:17,920 --> 00:10:22,100
+نطور الـ diagnostic services لماذا نرغب في تطوير
+
+133
+00:10:22,100 --> 00:10:28,160
+الخدمات التشخيصية تخيلوا القاعدة العامة إيش بتقول؟
+
+134
+00:10:28,160 --> 00:10:32,160
+بتقول أن the earlier the diagnosis the better the
+
+135
+00:10:32,160 --> 00:10:38,020
+outcome of the disease يعني إحنا شخصنا مرض مبكرًا،
+
+136
+00:10:38,020 --> 00:10:42,860
+تشخيص دقيق، عالجنا علاجًا specific وبالتالي الـ
+
+137
+00:10:42,860 --> 00:10:46,380
+outcome هتكون أفضل لكن لو تأخرنا في الـ diagnosis
+
+138
+00:10:46,380 --> 00:10:50,740
+وبدأنا نعمل guessing يعني إننا نخمن تخمين ونعطي علاج
+
+139
+00:10:50,740 --> 00:10:54,640
+ورا علاج ورا علاج إذا الأول ما جاوب إيش هيعمل؟
+
+140
+00:10:56,270 --> 00:11:00,310
+المرض نفسه ممكن يتطور ويعمل complications وكل ما
+
+141
+00:11:00,310 --> 00:11:03,810
+طولنا أكثر كل ما كانت الـ outcome أسوأ، وبالتالي
+
+142
+00:11:03,810 --> 00:11:08,410
+أنا بقول أن توفير diagnostics جيدة للفيروسات هو
+
+143
+00:11:08,410 --> 00:11:13,580
+أمر من أهم الأشياء المهمة جدًا الـ Diagnostic tests
+
+144
+00:11:13,580 --> 00:11:18,360
+based on antibody testing أو culturing are not
+
+145
+00:11:18,360 --> 00:11:22,940
+used يعني ما بنستخدمش serology فقط هنا الكشف عن
+
+146
+00:11:22,940 --> 00:11:27,620
+الـ cytology وعن الـ DNA hybridization technique
+
+147
+00:11:27,620 --> 00:11:32,040
+بالنسبة للـ treatment and prevention
+
+148
+00:11:35,430 --> 00:11:40,990
+الـ Warts بتاعة الجلد غالبًا تُزال إما بالـ Liquid
+
+149
+00:11:40,990 --> 00:11:45,090
+Nitrogen، عارفين الـ Liquid Nitrogen؟ اللي هو إيش
+
+150
+00:11:45,090 --> 00:11:50,050
+بيكون هذا؟ بيكون بارد جدًا، فلما بنحطه على الـ
+
+151
+00:11:50,050 --> 00:11:54,750
+Wart، بيتجمد وبينكسر كسر، تمام؟ بنكسر الجلد كسر،
+
+152
+00:11:54,750 --> 00:12:00,370
+تمام؟ بننزله بسهولة أو ممكن باستخدام Salicylic Acid
+
+153
+00:12:01,150 --> 00:12:04,610
+الساليسيليك أسيد هذا مش الأسبرين، الأسبرين إيش اسمه؟
+
+154
+00:12:04,610 --> 00:12:09,010
+أسيتيل ساليسيليك أسيد، هذا اسمه ساليسيليك أسيد استخدمناه
+
+155
+00:12:09,010 --> 00:12:11,250
+خدوا بالكم في علاج الفطريات، بنستخدم في علاج
+
+156
+00:12:11,250 --> 00:12:16,050
+الفطريات بين الأصابع، ساليسيليك أسيد، لأنه keratolytic
+
+157
+00:12:16,050 --> 00:12:20,100
+agent، إيش يعني keratolytic agent؟ يعني محلل لطبقة
+
+158
+00:12:20,100 --> 00:12:24,420
+الكيراتين اللي موجودة في وين؟ في الجلد، فلو يكون عندي
+
+159
+00:12:24,420 --> 00:12:30,540
+ثاليل نُبع قطعة صغيرة من بلاستر عليها ساليسيليك أسيد على 
+
+160
+00:12:30,540 --> 00:12:35,040
+اللي هو مين؟ على الثاليل سواء كان الثاليل موجودة في
+
+161
+00:12:35,040 --> 00:12:39,100
+الأيدين أو في القدم اللي سميناها planters وكل فترة
+
+162
+00:12:39,100 --> 00:12:43,720
+وفترة بنغير هذا اللاصق يعني بنضيف ساليسيليك أسيد جديد
+
+163
+00:12:43,720 --> 00:12:47,900
+وبعد فترة بيختفي يعني literally بيذوب حرفيًا
+
+164
+00:12:47,900 --> 00:12:54,440
+الثاليل بيذوب وبتختفي باستخدام الساليسيليك أسيد طبعًا هي
+
+165
+00:12:54,440 --> 00:13:00,340
+طريقة بطيئة بينما الـ liquid nitrogen تمام بتكون
+
+166
+00:13:00,340 --> 00:13:03,580
+سريعة جدًا لإنه بتتم في ظروف زي وإذا كنا بنعمل
+
+167
+00:13:03,580 --> 00:13:09,180
+surgery اللي هي جراحة بالنسبة لـ Genital Warts
+
+168
+00:13:09,180 --> 00:13:11,940
+المنطقة الجنسية حساسة مش زي الجلد العادي فبالتالي
+
+169
+00:13:11,940 --> 00:13:17,060
+يصعب تطبيق ما طبقناه على الـ skin warts فبيستخدموا
+
+170
+00:13:17,060 --> 00:13:21,100
+مادة اسمها Podophyllin أو Alpha Interferon
+
+171
+00:13:26,470 --> 00:13:30,310
+ممكن لو كان عندنا severe infection نستخدم antiviral
+
+172
+00:13:30,310 --> 00:13:33,770
+drug في حالات نادرة اللي هو الـ Cidofovir
+
+173
+00:13:33,770 --> 00:13:36,670
+واستخدمناها على فكرة إحنا في أكثر من مناسبة
+
+174
+00:13:36,670 --> 00:13:42,690
+وخاصة في الـ immunocompromised patients مازلنا في
+
+175
+00:13:42,690 --> 00:13:44,350
+الـ treatment و الـ prevention وبنتكلم إيه أنا عن
+
+176
+00:13:44,350 --> 00:13:49,950
+مين؟ عن الـ vaccine في الـ 2006 تم اعتماد الـ vaccine
+
+177
+00:13:49,950 --> 00:13:55,970
+من قبل الـ FDA إيش الـ FDA يا بنات اسمها؟ Food and 
+
+178
+00:13:55,970 --> 00:14:00,370
+Drug Administration منظمة الغذاء والدواء في
+
+179
+00:14:00,370 --> 00:14:04,530
+الولايات المتحدة وهي من المنظمات القوية جدًا من
+
+180
+00:14:04,530 --> 00:14:08,610
+ناحية علمية ومن ناحية سلطة علمية بمعنى عندما أقول
+
+181
+00:14:08,610 --> 00:14:13,890
+أن الـ FDA عملت approval له في هذه شهادة يعني بتأهله
+
+182
+00:14:13,890 --> 00:14:17,750
+للمبيعات في كل أنحاء العالم لإنه هي بالفعل مؤسسة
+
+183
+00:14:17,750 --> 00:14:23,250
+قوية ونظامها ما بيعمل approval لـ drug إلا بعد أو
+
+184
+00:14:23,250 --> 00:14:28,770
+غذاء إلا بعد تجارب قد تستمر إلى عشر سنوات تخيلوا
+
+185
+00:14:28,770 --> 00:14:32,830
+يعني تجارب بتكون فترة طويلة حتى يجمعوا سلامة هذا
+
+186
+00:14:32,830 --> 00:14:38,820
+المنطق against four types، إيش هما الـ types دول؟
+
+187
+00:14:38,820 --> 00:14:43,880
+6، 11، 16، 18 اللي هم مجرد من عنهم involve مين في
+
+188
+00:14:43,880 --> 00:14:51,170
+الـ genital tract وممكن سببه كارسينوما مين بيقعد على
+
+189
+00:14:51,170 --> 00:14:58,250
+الـ vaccine؟ للفتيات من عمر 9 إلى 26 عام خدوا بالكم
+
+190
+00:14:58,250 --> 00:15:03,590
+النقطة الـ papilloma virus أكثر انتشارًا بين الأطفال
+
+191
+00:15:03,590 --> 00:15:08,050
+والـ young adults من الـ young adults أنتم أنتم young
+
+192
+00:15:08,050 --> 00:15:13,430
+adults مظبوط الآن كل ما كبرنا في السن أكثر كل ما
+
+193
+00:15:13,430 --> 00:15:17,290
+قلت احتمالية إصابتنا بالـ papilloma virus وصل
+
+194
+00:15:17,290 --> 00:15:21,550
+الصورة فبالتالي at early stage ولأن هذا .. هذا ..
+
+195
+00:15:21,550 --> 00:15:24,230
+هذا كنا بننتقل عن طريق الجنس فبدأ فلا يقطع للناس
+
+196
+00:15:24,230 --> 00:15:27,570
+العاديين يقطع فقط في المرحلة اللي ممكن يصير فيها
+
+197
+00:15:27,570 --> 00:15:32,890
+ممارسة جنسية واحدة من سن تسع سنوات فما فوق طبعًا 26
+
+198
+00:15:32,890 --> 00:15:38,730
+سنة لأنه بعد 26 سنة أصلًا إحصائيًا نسبة المصابين ب
+
+199
+00:15:38,730 --> 00:15:43,210
+الـ الـ الـ الـ papilloma virus بتكون نسبة قليلة فاهمة
+
+200
+00:15:43,210 --> 00:15:46,030
+أن هذه الـ category أو هذه الفئة اللي ممكن ياخدوا
+
+201
+00:15:46,030 --> 00:15:51,600
+فيها الـ vaccine طبعًا كأي مرض آخر يمكن أنتم تتذكروا
+
+202
+00:15:51,600 --> 00:15:54,220
+لما تكلمنا عن الـ herpes أو الـ genital herpes
+
+203
+00:15:54,220 --> 00:15:57,180
+بيقولوا لنا أن الـ C-section أو الـ cesarean section
+
+204
+00:15:57,180 --> 00:16:01,940
+للامهات الحوامل هي وسيلة لإنقاذ الطفل من الإصابة
+
+205
+00:16:01,940 --> 00:16:05,780
+بمين؟ بالـ genital herpes هذا الكلام كان صحيح
+
+206
+00:16:05,780 --> 00:16:09,240
+بالنسبة للـ genital herpes لكن بالنسبة للـ
+
+207
+00:16:09,240 --> 00:16:15,170
+papilloma إجراء عملية قيصرية لتجنيب الطفل أو
+
+208
+00:16:15,170 --> 00:16:20,670
+المولود الإصابة، هذا أمر غير مؤكد، بمعنى أن
+
+209
+00:16:20,670 --> 00:16:24,730
+الدراسات اللي انعملت في هذا المجال لم تعطينا إجابة
+
+210
+00:16:24,730 --> 00:16:27,610
+واضحة فيما إذا كانت الـ Caesarian section هتحمي
+
+211
+00:16:27,610 --> 00:16:30,370
+الطفل ولا مش هتحمي هذا الطفل
+
+212
+00:16:32,640 --> 00:16:37,520
+الفيروس الأخير في السلسلة اللي هو الـ Parvo virus
+
+213
+00:16:37,520 --> 00:16:41,680
+والذي طبعًا يعني اتفقنا على أنه مجرد أن نسمعه بدنا
+
+214
+00:16:41,680 --> 00:16:48,050
+نتذكر المرض اللي اسمه slapped-cheek syndrome على الرغم
+
+215
+00:16:48,050 --> 00:16:52,430
+من أن فقط هذا الاسم هو الشائع، لكن يجب أن نعرف أنه
+
+216
+00:16:52,430 --> 00:16:56,850
+ليس هو المرض الوحيد اللي بسببه هذا الفيروس، لكن
+
+217
+00:16:56,850 --> 00:17:01,950
+هذا الفيروس تميز عن باقي مجموعته في الـ DNA viruses
+
+218
+00:17:01,950 --> 00:17:08,010
+بإيش؟ بأنه single-stranded DNA، كلهم double
+
+219
+00:17:08,010 --> 00:17:11,290
+-stranded ما عدا هذا الفيروس
+
+220
+00:17:14,250 --> 00:17:17,870
+طيب قبل ما ننتقل للمعلومات الأخرى خليني أنا أنقش
+
+221
+00:17:17,870 --> 00:17:22,050
+معاكم قضية لابد أنه نذكركم فيها وننبهكم عليها
+
+222
+00:17:22,050 --> 00:17:29,190
+دائمًا إحنا عندنا انطباع أن من يمتلك الصفة هو أفضل من
+
+223
+00:17:29,190 --> 00:17:33,650
+من لا يمتلك هذه الصفة أنا بتكلم عن enveloped و non
+
+224
+00:17:33,650 --> 00:17:38,350
+enveloped المحاضرات السابقة تكلمنا كثير عن الـ
+
+225
+00:17:38,350 --> 00:17:42,580
+enveloped عن الـ herpes وعن الـ pox viruses وكنا
+
+226
+00:17:42,580 --> 00:17:47,340
+شوية عن الـ hepadna viruses وإننا يوميًا متكلم عن الـ
+
+227
+00:17:47,340 --> 00:17:50,300
+non-enveloped ممكن تاخدوا انطباع أن الـ non
+
+228
+00:17:50,300 --> 00:17:55,180
+-enveloped أقل شأنًا من من؟ من الـ enveloped لأن
+
+229
+00:17:55,180 --> 00:17:58,000
+الناس يمتلكوا الصفة والناس يمتلكوا الصفة بالعكس
+
+230
+00:17:59,140 --> 00:18:04,120
+امتلاك envelope درسناها في أول الفصل confers
+
+231
+00:18:04,120 --> 00:18:08,520
+instability to the virus يعني لو رميناها في البيئة
+
+232
+00:18:08,520 --> 00:18:14,600
+بيتدمر بسهولة بيتدمر بسهولة لذاك الانتقال تبعه كان
+
+233
+00:18:14,600 --> 00:18:17,720
+دائمًا عبر الـ respiratory tract أو عبر الـ sexual
+
+234
+00:18:17,720 --> 00:18:23,490
+contact بينما الفيروسات اللي ما لهاش envelope بتكون
+
+235
+00:18:23,490 --> 00:18:26,910
+stable و could be transmitted by different means و
+
+236
+00:18:26,910 --> 00:18:30,910
+من ضمنها الـ gastrointestinal مظبوط وهناك و
+
+237
+00:18:30,910 --> 00:18:35,250
+أتحداكم إذا بدي بولي virus بيعمل gastrointestinal
+
+238
+00:18:35,250 --> 00:18:38,490
+infection ويكون له envelope مستحيل اللي جاي هذا
+
+239
+00:18:38,490 --> 00:18:42,490
+الكلام على الأقل في الفيروسات اللي إحنا بنعرفها
+
+240
+00:18:42,490 --> 00:18:46,750
+لحد الآخر بس حبيت أذكركم بهذه النقطة لأن البعض زي
+
+241
+00:18:46,750 --> 00:18:50,090
+ما حكيتلكم يميل إلى تفضيل من يمتلك الصفة على
+
+242
+00:18:54,690 --> 00:18:58,590
+الـ Parvo virus بي ناينتين كنا بسبب الـ slapped-cheek
+
+243
+00:18:58,590 --> 00:19:02,670
+syndrome اللي اسمها erythremia infectionism أو كان
+
+244
+00:19:02,670 --> 00:19:08,170
+يسموها fifth disease المرض الخامس وذكرناكم إيش
+
+245
+00:19:08,170 --> 00:19:12,450
+المرض الخامس كان أربعة في أربعة أمراض بتعمل rashes
+
+246
+00:19:12,450 --> 00:19:17,090
+وخلينا نتكلم على الـ rashes شوية الـ rashes أو الطفح
+
+247
+00:19:17,090 --> 00:19:24,570
+الجلدي اللي بينتج من خلال هذا الفيروس كده بينتج أن
+
+248
+00:19:24,570 --> 00:19:29,570
+الفيروس بيصيب الـ endothelium بتاع مين؟ بتاع الـ vascular
+
+249
+00:19:29,570 --> 00:19:33,350
+tissue، ما هو الـ vascular tissue؟ الـ capillaries والـ veins،
+
+250
+00:19:33,350 --> 00:19:38,540
+طبعًا الـ capillaries أرق وأقل سمكًا من الـ veins و 
+
+251
+00:19:38,540 --> 00:19:43,120
+الارتريا، صح ولا لأ؟ فلو صار فيه infection في الـ
+
+252
+00:19:43,120 --> 00:19:47,120
+endothelium والخلايا الـ cytotoxic T cell أو 
+
+253
+00:19:47,120 --> 00:19:50,860
+الفيروس دمرها، بعد فترة تتدمر الخلايا اللي وراها،
+
+254
+00:19:50,860 --> 00:19:55,180
+اللي وراها، بصير فيه endothelium فالدم بيهرب من هذه
+
+255
+00:19:55,180 --> 00:19:59,340
+الثقوب إلى الخارج، وين بروح؟ تحت الجلد، مظبوط؟
+
+256
+00:19:59,340 --> 00:20:03,080
+فاحنا بنشوف راش، الراش عبارة عن إيش هذا، عن
+
+257
+00:20:03,080 --> 00:20:09,020
+هروب للدم من الكابلاريز إلى الجلد، مين المسؤول
+
+258
+00:20:09,020 --> 00:20:13,940
+عنه؟ الـ pathogen، أي pathogen، عنده مقدرة على إنه
+
+259
+00:20:13,940 --> 00:20:17,280
+يعمل infection للـ endothelial cells تمام، بيقدر
+
+260
+00:20:17,280 --> 00:20:21,200
+يعمل هذه العملية، مثلا في البكتيريا الريكيزيا مشهورة
+
+261
+00:20:21,200 --> 00:20:24,920
+جدا مشهورة الريكيزيا أنها تعمل infection في
+
+262
+00:20:24,920 --> 00:20:29,080
+الاندوثيليا وبالتالي مرضى الـ typhus مش الـ typhoid
+
+263
+00:20:29,080 --> 00:20:33,040
+هم الـ typhus بيكون عندهم rash .. بيكون عندهم rash
+
+264
+00:20:33,040 --> 00:20:37,000
+نفس الفكرة إن هنا برضه بصير rash ناجم عن مين كنا
+
+265
+00:20:37,000 --> 00:20:41,890
+عن قدرة الفيروس على إصابة الـ endothelial cell إذا
+
+266
+00:20:41,890 --> 00:20:44,830
+اتفقنا إن الـ fifth disease أو الارتريميا
+
+267
+00:20:44,830 --> 00:20:48,890
+infectious أو اللي سميناها slapped chick syndrome هذه
+
+268
+00:20:48,890 --> 00:20:54,370
+واحد من الأمراض فيها إنه aplastic anemia نوع خطير
+
+269
+00:20:54,370 --> 00:20:59,270
+من الأنيميا هنشوفه كمان شوية من إيش بتسبب خاصة عند
+
+270
+00:20:59,270 --> 00:21:03,370
+المرضى الذين لديهم sickle cell anemia يعني لو واحد
+
+271
+00:21:03,370 --> 00:21:07,390
+عنده sickle cell anemia وأصيب بالفيروس احتمالية
+
+272
+00:21:07,390 --> 00:21:11,760
+إنه يصاب بـ aplastic anemia بتكون عالية جدا النوع
+
+273
+00:21:11,760 --> 00:21:14,760
+التالت من الإصابات اللي هو الـ fetal وكلمة fetal
+
+274
+00:21:14,760 --> 00:21:20,100
+هنا جنينية يعني يصيب طفل الجنين عفوا بالمرض
+
+275
+00:21:20,100 --> 00:21:25,580
+Including hydrops fetalis إيش يعني hydrops fetalis؟
+
+276
+00:21:25,580 --> 00:21:29,760
+ركزوا معايا في هذه الجزئية عشان بدنا نفهمها كويس
+
+277
+00:21:29,760 --> 00:21:34,780
+أول حاجة hydrops fetalis معناها إن الجنين مليان ميه
+
+278
+00:21:34,780 --> 00:21:43,460
+مليء بالماء متدفخ كويس إيش سبب الانتفاخ تبعه؟ طلع
+
+279
+00:21:43,460 --> 00:21:46,640
+من وين .. من وين بتيجي الجثة؟ بتيجي من إنه الـ
+
+280
+00:21:46,640 --> 00:21:50,000
+virus بيعمل infection للاريثروبلاست. إيش
+
+281
+00:21:50,000 --> 00:21:56,290
+الاريثروبلاست هذه؟ اللي هي immature RBC's تمام؟
+
+282
+00:21:56,290 --> 00:21:59,970
+يبقى الـ RBC's مش هيتكون، يبقى حاجة يصير في عندي
+
+283
+00:21:59,970 --> 00:22:05,370
+أنيميا، لما يصير في عندي أنيميا، القلب بضطر يضغط
+
+284
+00:22:05,370 --> 00:22:10,270
+حاله مرارا وتكرارا عشان يوصل دم وأكسجين، فبيعمل
+
+285
+00:22:10,270 --> 00:22:13,970
+حاجة اسمها congestive heart failure، إذن infection
+
+286
+00:22:13,970 --> 00:22:17,810
+للاريثروبلاست يعني أنيميا، 
+
+287
+00:22:17,810 --> 00:22:21,590
+أنيميا يعني congestive heart failure، بعدين بيطلع
+
+288
+00:22:21,590 --> 00:22:24,630
+اللي هو الاديمة أو الاستسقاء اللي حكينا عنه، اللي
+
+289
+00:22:24,630 --> 00:22:29,230
+سوف يؤدي في النهاية إلى الـ hydrops fetalis تحت المارين،
+
+290
+00:22:29,230 --> 00:22:33,430
+إذا عرفنا الـ rash كيف إجا، وعرفنا الـ hydrops fetalis في
+
+291
+00:22:33,430 --> 00:22:36,990
+تالس أيضا كمان كيف إجا، وطبعا في النص هنا، الـ
+
+292
+00:22:36,990 --> 00:22:39,470
+aplastic أنيميا أكيد برضه من الـ destruction لمين؟
+
+293
+00:22:39,470 --> 00:22:40,710
+من الاريثروبلاست
+
+294
+00:22:42,790 --> 00:22:48,730
+طيب صفات عامة عن الـ parvo B19 it is very small
+
+295
+00:22:48,730 --> 00:22:52,410
+non enveloped with a single stranded DNA وهذا
+
+296
+00:22:52,410 --> 00:22:55,430
+اتفقنا عليها إن هو أصلا بيميزه عن باقي الفيروسات
+
+297
+00:22:55,430 --> 00:22:58,290
+الأخرى من الـ DNA وهو negative strand مش الـ
+
+298
+00:22:58,290 --> 00:23:00,970
+positive strand كمان negative strand because a
+
+299
+00:23:00,970 --> 00:23:04,490
+viral and only one serotype لذلك الـ immunity غالبا
+
+300
+00:23:04,490 --> 00:23:08,010
+life long يعني وصار فيه الإنسان مرة و بتحميه طول
+
+301
+00:23:08,010 --> 00:23:12,320
+العمر بينتقل عن طريق الـ Respiratory وممكن عن طريق
+
+302
+00:23:12,320 --> 00:23:16,380
+الـ Transplacental كمان الـ blood donation ممكن
+
+303
+00:23:16,380 --> 00:23:19,660
+كمان يكون وسيلة من وسائل اللي هو انتقال هذا الـ
+
+304
+00:23:19,660 --> 00:23:23,560
+disease المرض worldwide عالميا ولكن تتخيلوا إن
+
+305
+00:23:23,560 --> 00:23:26,480
+الولايات المتحدة لحالها خمسين بالمائة من اللي
+
+306
+00:23:26,480 --> 00:23:29,840
+عمرهم من فوق التمنتاشر سنة مصابين أو عندهم
+
+307
+00:23:29,840 --> 00:23:33,240
+antibodies لهذا الفيروس إيش عندهم antibodies؟ يعني
+
+308
+00:23:33,240 --> 00:23:36,380
+في يوم من الأيام كانوا مصابين بهذا الفيروس fifty
+
+309
+00:23:36,380 --> 00:23:41,340
+percent of the population مصابين بهذا الـ .. الـ
+
+310
+00:23:41,340 --> 00:23:44,720
+disease humans are the natural .. natural reservoir
+
+311
+00:23:44,720 --> 00:23:48,020
+لأن there is no animal reservoir وهذا برضه من
+
+312
+00:23:48,020 --> 00:23:52,300
+الأشياء اللي لو في يوم من الأيام يكون لنا الـ
+
+313
+00:23:52,300 --> 00:23:56,660
+vaccine تمام بالتأكيد هيساعدنا في التخلص من هذا الـ
+
+314
+00:23:56,660 --> 00:24:00,300
+disease هذا
+
+315
+00:24:00,300 --> 00:24:05,740
+الـ .. الصبورة هو اللي ذكرناها قبل قليل إن الـ B19
+
+316
+00:24:07,110 --> 00:24:10,550
+بيشتغل على نوعين من الخلايا جنّا الـ red blood
+
+317
+00:24:10,550 --> 00:24:13,410
+cell precursors اللي هي الارترو بلاست والتانية
+
+318
+00:24:13,410 --> 00:24:15,930
+اللي هي الـ endothelial cells in the blood vessel
+
+319
+00:24:15,930 --> 00:24:20,530
+ووضّحنا نتيجة كل واحدة أو نتيجة إصابة كل واحدة
+
+320
+00:24:20,530 --> 00:24:25,890
+منهم إيش بتقدر الصورة بتاعة هذا هي اللي بتعبر عن
+
+321
+00:24:25,890 --> 00:24:28,250
+الـ Hydrops fetalis اللي قلنا لكوا عنه اللي هو
+
+322
+00:24:28,250 --> 00:24:31,110
+الاستسقاء بيكون عالي جدا أو الإدينة بتكون عالية جدا
+
+323
+00:24:31,110 --> 00:24:36,670
+في هذا الطفل وحاولنا نوضح لكم إنه ناتج عن
+
+324
+00:24:36,670 --> 00:24:40,010
+إصابة الخلايا اللي هي الاريثروبلاست اللي بيصيبها الفيروس
+
+325
+00:24:40,010 --> 00:24:44,430
+بتموت ثم يؤدي ذلك إلى نقص في كرات الدم الحمراء،
+
+326
+00:24:44,430 --> 00:24:48,310
+أنيميا، congestive heart failure هو بتقيتله جن
+
+327
+00:24:48,310 --> 00:24:52,680
+اللي هو الـ hydrops fetalis كما ذكرت أيضا قبل ما
+
+328
+00:24:52,680 --> 00:24:57,020
+أنقل لوحة lifelong immunity against infection يعني
+
+329
+00:24:57,020 --> 00:25:01,380
+الإصابة بتعطي بتوفر حماية للأبد أو لطول العمر
+
+330
+00:25:04,640 --> 00:25:08,180
+الـ Clinical findings زي ما حكينا الطبيب بقدر يشوف
+
+331
+00:25:08,180 --> 00:25:11,020
+اللي هي الـ Erythema infectiosum اللي هي الـ
+
+332
+00:25:11,020 --> 00:25:13,340
+Slapped Chick Syndrome أو الـ Fifth Disease
+
+333
+00:25:13,340 --> 00:25:16,720
+ومذكورة إن على اللوحة هنا الأربع أمراض الأخرى
+
+334
+00:25:16,720 --> 00:25:21,620
+اللي بناء عليها سمينا المرض الخامس الـ Measles والـ
+
+335
+00:25:21,620 --> 00:25:25,240
+Rubella والـ Scarlet Fever والـ  Roseola تلاتة منهم
+
+336
+00:25:25,240 --> 00:25:29,100
+فيروسات واحدة فقط اللي هي البكتيريا .. أي واحدة من
+
+337
+00:25:29,100 --> 00:25:35,440
+البكتيريا Scarlet Fever الحمى القرمزية مين بيعرف مين
+
+338
+00:25:35,440 --> 00:25:41,340
+مسبب الحمى القرمزية؟ الـ Streptococcus pyogenes رقم اتنين
+
+339
+00:25:41,340 --> 00:25:44,440
+من الـ diseases هي aplastic anemia, fetal infection,
+
+340
+00:25:44,700 --> 00:25:46,720
+and arthritis الـ arthritis من وين جاية الـ
+
+341
+00:25:46,720 --> 00:25:52,080
+arthritis؟ الـ arthritis جاية من الـ antigen
+
+342
+00:25:52,080 --> 00:25:56,070
+-antibody complexes اللي همش .. مش .. هي مش
+
+343
+00:25:56,070 --> 00:26:01,170
+autoimmune هو الـ antibody بيتفعل مع fragment من الـ
+
+344
+00:26:01,170 --> 00:26:05,190
+virus بيرتبط معاها وبيترسق في أماكن منها اللي هم
+
+345
+00:26:05,190 --> 00:26:09,850
+المفاصل وبالتالي antigen antibody reaction
+
+346
+00:26:09,850 --> 00:26:12,770
+activation للـ complement attack للـ tissue
+
+347
+00:26:12,770 --> 00:26:16,230
+تبعنا منها وبالتالي بيصير فيه destruction وبيصير
+
+348
+00:26:16,230 --> 00:26:18,930
+في الـ arthritis اللي احنا بنشوفها انتهول على المرض
+
+349
+00:26:19,570 --> 00:26:22,630
+طبعا ممكن .. ممكن بعض الأطفال يعني تستمر فيهم
+
+350
+00:26:22,630 --> 00:26:25,150
+العدوى لفترة طويلة وتسبب إنها حالة اسمها chronic
+
+351
+00:26:25,150 --> 00:26:32,650
+B19 infection الـ Lab diagnosis الـ fifth disease
+
+352
+00:26:32,650 --> 00:26:36,330
+and aplastic anemia are usually diagnosed by
+
+353
+00:26:36,330 --> 00:26:41,870
+detecting IgM لحظة إن مش كل الفيروسات واحد يعني
+
+354
+00:26:41,870 --> 00:26:44,850
+الفيروس اللي جابله اللي هو الـ papilloma virus الـ
+
+355
+00:26:44,850 --> 00:26:49,150
+serology كان عدي من الفائدة صح؟ لكن هنا الـ
+
+356
+00:26:49,150 --> 00:26:54,410
+serology كان هو الأساس الـ detection of IgM أساس في
+
+357
+00:26:54,410 --> 00:26:57,530
+عملية تشخيص اللي قلنا الـ aplastic anemia والـ
+
+358
+00:26:57,530 --> 00:27:01,160
+fifth disease أو الـ erythema infectiosum الـ B
+
+359
+00:27:01,160 --> 00:27:06,460
+virus can be isolated from throat swab مسحة برضه والـ
+
+360
+00:27:06,460 --> 00:27:12,340
+cell culture لعزل هذا الفيروس لكن هذه التقنية في
+
+361
+00:27:12,340 --> 00:27:17,480
+توفر الـ serology تمام أنتو عارفين الـ viral cell
+
+362
+00:27:17,480 --> 00:27:23,380
+culture takes days تأخد أيام طويلة والعملية تبقى
+
+363
+00:27:23,380 --> 00:27:28,300
+أكثر تكلفة من اللي هو الـ serology وبالتالي بيميلوا
+
+364
+00:27:28,300 --> 00:27:32,660
+إلى الـ serology الـ immunocompromised patient ممكن
+
+365
+00:27:32,660 --> 00:27:35,480
+نستخدمه لأنه الـ immunocompromised patient هيعطينا
+
+366
+00:27:35,480 --> 00:27:38,940
+false negative results ليش؟ هيعطينا false negative
+
+367
+00:27:38,940 --> 00:27:43,340
+result لأنه أصلا ماعندوش قدرة مناعية يستجيب
+
+368
+00:27:43,340 --> 00:27:47,740
+للفيروس وبالتالي لن يكون antibodies والفحص هيطلع
+
+369
+00:27:47,740 --> 00:27:52,040
+negative في هذا الحال إذا ما الحل؟ إننا مضطرين
+
+370
+00:27:52,040 --> 00:27:57,580
+نأخذ اللي هو عينة الدم وندور على الـ DNA بتاع
+
+371
+00:27:57,580 --> 00:28:01,060
+الفيروس باستخدام الـ molecular techniques زي الـ PCR
+
+372
+00:28:03,260 --> 00:28:06,700
+كذلك الأمر لو كانت الأم مصابة واحنا خايفين إن
+
+373
+00:28:06,700 --> 00:28:10,600
+الجنين يكون مصاب شفنا الطبيب بالنساء والولادة في
+
+374
+00:28:10,600 --> 00:28:14,580
+الـ ultrasound شاف الطفل عنده hydrops fetalis من
+
+375
+00:28:14,580 --> 00:28:21,080
+خلال التصوير قد يلجأ إلى فحص الجنين من خلال الـ PCR
+
+376
+00:28:21,080 --> 00:28:24,700
+للـ amniotic fluid يعني ناخد السائل الجنيني و نمله
+
+377
+00:28:24,700 --> 00:28:31,480
+برضه PCR Treatment and Prevention There is no
+
+378
+00:28:31,480 --> 00:28:37,200
+specific treatment for B19 infection يعني حتى لو 
+
+379
+00:28:37,200 --> 00:28:47,180
+شخصنا ما فيش علاج محدد للمرض لكن في mitigation
+
+380
+00:28:47,180 --> 00:28:52,900
+measures باستخدام pooled antiserum إيش يعني pooled
+
+381
+00:28:52,900 --> 00:28:56,620
+antiserum يعني antiserum من مصادر مختلفة فيها
+
+382
+00:28:56,620 --> 00:29:02,420
+antibodies للـ B19 بنجمعها و بنعطي حقن للمرضى خاصة
+
+383
+00:29:02,420 --> 00:29:07,680
+للناس اللي عندهم أيه immunodeficiency ولا يوجد أي
+
+384
+00:29:07,680 --> 00:29:12,760
+vaccination ولا أي chemoprophylaxis لهذا الـ
+
+385
+00:29:12,760 --> 00:29:19,440
+disease إذا الـ B19 كم مرض شفنا إلو تقريبا تلاتة
+
+386
+00:29:19,440 --> 00:29:24,860
+رئيسين، إيش هما التلاتة الرئيسين؟ أشهر واحدة ..
+
+387
+00:29:24,860 --> 00:29:27,400
+أشهر واحدة اللي هي الـ Erythema Infectiosum اللي
+
+388
+00:29:27,400 --> 00:29:30,240
+جونا عنها الـ Slapped Cheek Syndrome، بعدين
+
+389
+00:29:30,240 --> 00:29:33,600
+Aplastic Anemia، بعدين جونا الـ Fetal Infection
+
+390
+00:29:33,600 --> 00:29:37,040
+اللي هي الـ Hydrops Fetalis، وفي ضمن الصياق
+
+391
+00:29:37,040 --> 00:29:40,540
+تكلمنا عن Arthritis، صح ولا لأ؟ تكلمنا عن
+
+392
+00:29:40,540 --> 00:29:47,290
+Arthritis الآن هذه الأمراض غالبا كلها self-limited
+
+393
+00:29:47,290 --> 00:29:51,230
+إيش يعني self-limited كام مرة؟ يعني بتشفى لوحدها
+
+394
+00:29:51,230 --> 00:29:57,010
+إلا في ذوي المناعة المنخفضة وهذا اللي يعني عدم
+
+395
+00:29:57,010 --> 00:30:01,310
+الخطورة العالية لهذا الـ disease تمام يمكن هو اللي
+
+396
+00:30:01,310 --> 00:30:05,830
+مش مخلي البحث الجاد عن vaccine أو vaccination
+
+397
+00:30:05,830 --> 00:30:10,330
+program بتلاحظوا شغل إنه الإصابة بتعطي
+
+398
+00:30:17,320 --> 00:30:21,880
+لكن نسبة عالية من الناس تصاب بهذا الفيروس وكان
+
+399
+00:30:21,880 --> 00:30:26,670
+فيروس بدنا نطعم الناس ضده فخلّينا نطعم الناس ضد
+
+400
+00:30:26,670 --> 00:30:31,870
+الفيروسات التي لها قدرة قتل عالية زي الـ smallpox
+
+401
+00:30:31,870 --> 00:30:37,370
+زي الـ .. مؤلمة زي الـ chickenpox تمام أفضل تحاول
+
+402
+00:30:37,370 --> 00:30:41,250
+ندوله على الـ HIV على الـ AIDS أن نحاول ندوله على الـ
+
+403
+00:30:41,250 --> 00:30:44,290
+vaccine بهيك احنا بنكون انتهينا من .. انتهينا من
+
+404
+00:30:44,290 --> 00:30:48,690
+أيه؟ من الـ DNA envelope viruses و الـ DNA non
+
+405
+00:30:48,690 --> 00:30:52,050
+envelope viruses إن شاء الله بيكون في موضوع جديد
+
+406
+00:30:52,050 --> 00:30:52,690
+المرة القادمة