62301
document
Etomidate with or without flumazenil anesthesia for stem cell transplantation in autistic children . BACKGROUND The aim of this study was to investigate etomidate administration with or without flumazenil in autistic children who underwent intrathecal transplantation of stem cells by lumbar puncture . METHODS Forty autistic children aged 2-12 , who were scheduled for stem cell transplantation via lumbar puncture under anesthesia , were randomized for a double-blind study . The children were randomly assigned to two groups : the flumazenil group ( group F , n=20 ) and the etomidate group ( group E , n=20 ) . All children received 0.2 mg/kg of etomidate . In the case of inadequate anesthesia , patients received repeated doses of 0.1 mg/kg of etomidate until reaching deep sedation . After operation , children in group F were given flumazenil ( 0.01 mg/kg ) and children in group E received placebo . Heart rate ( HR ) , mean arterial pressure , oxygen saturation , respiratory rate , the Ramsay sedation score ( RSS ) , and recovery time of all children were continuously monitored and recorded during the entire procedure . RESULTS After anesthesia , blood pressure and HR measurements were not significantly changed in both groups compared with the baseline . There were no respiratory depression , bradycardia , hypotension , nausea , and vomiting . Five patients complained of pain on the site of injection . Myoclonus occurred in seven patients . Recovery time in group F was significantly shorter than in group E ( p < 0.001 ) , and after the injection of flumazenil , RSS in group F significantly decreased than in group E. There were no significant differences in operation time . Physician satisfaction in both groups was similar . CONCLUSIONS Etomidate resulted in stable hemodynamic responses and relatively less adverse effects , and flumazenil antagonized the anesthetic effect of etomidate ; thus , etomidate with flumazenil is suitable for performing stem cell transplantation in autistic children .
62302
Intervention_Pharmacological
Etomidate
62303
Intervention_Pharmacological
flumazenil anesthesia
62304
Intervention_Pharmacological
etomidate
62305
Intervention_Pharmacological
flumazenil
62306
Intervention_Pharmacological
flumazenil
62307
Intervention_Pharmacological
etomidate
62308
Intervention_Pharmacological
etomidate
62309
Intervention_Pharmacological
etomidate
62310
Intervention_Pharmacological
flumazenil
62311
Intervention_Control
placebo
62312
Intervention_Pharmacological
flumazenil
62313
Intervention_Pharmacological
Etomidate
62314
Intervention_Pharmacological
flumazenil
62315
Outcome_Physical
Heart rate ( HR )
62316
Outcome_Physical
mean arterial pressure
62317
Outcome_Physical
oxygen saturation
62318
Outcome_Physical
respiratory rate
62319
Outcome_Physical
Ramsay sedation score ( RSS )
62320
Outcome_Physical
recovery time
62321
Outcome_Physical
blood pressure
62322
Outcome_Physical
HR measurements
62323
Outcome_Physical
respiratory depression
62324
Outcome_Physical
bradycardia
62325
Outcome_Physical
hypotension
62326
Outcome_Physical
nausea
62327
Outcome_Physical
vomiting
62328
Outcome_Pain
pain on the site of injection
62329
Outcome_Adverse-effects
Myoclonus
62330
Outcome_Physical
Recovery time
62331
Outcome_Physical
RSS
62332
Outcome_Other
operation time
62333
Outcome_Other
Physician satisfaction
62334
Outcome_Physical
hemodynamic responses
62335
Outcome_Adverse-effects
adverse effects
62336
Outcome_Physical
anesthetic effect
62337
Participant_Condition
autistic children .
62338
Participant_Condition
autistic children who underwent intrathecal transplantation of stem cells by lumbar puncture .
62339
Participant_Condition
Forty autistic children aged 2-12 , who were scheduled for stem cell transplantation via lumbar puncture under anesthesia
62340
Participant_Condition
autistic children .