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Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis . INTRODUCTION Our aim was to evaluate the safety and efficacy of a low-intensity resistance training program combined with partial blow flow restriction ( BFR training ) in a cohort of patients with polymyositis ( PM ) and dermatomyositis ( DM ) . METHODS In total , 13 patients with PM and DM completed a 12-week twice a week low-intensity ( that is , 30 % one-repetition-maximum ( 1RM ) ) resistance exercise training program combined with partial blood flow restriction ( BFR ) . Assessments of muscle strength , physical function , quadriceps cross sectional ( CSA ) area , health-related quality of life , and clinical and laboratory parameters were assessed at baseline and after the intervention . RESULTS The BFR training program was effective in increasing the maximal dynamic strength in both the leg-press ( 19.6 % , P < 0.001 ) and knee-extension exercises ( 25.2 % P < 0.001 ) , as well as in the timed-stands ( 15.1 % , P < 0.001 ) and timed-up-and-go test ( -4.5 % , P =0.002 ) . Quadriceps CSA was also significantly increased after the intervention ( 4.57 % , P =0.01 ) . Similarly , all of the components of the Short Form-36 Health Survey , the Health Assessment Questionnaire scores , and the patient- and physician reported Visual Analogue Scale were significantly improved after training ( P < 0.05 ) . Importantly , no clinical evidence or any other self-reported adverse event were found . Laboratory parameters ( creatine kinase and aldolase ) were also unchanged ( P > 0.05 ) after the intervention . CONCLUSIONS We demonstrated that a 12-week supervised low-intensity resistance training program associated with partial blood flow restriction may be safe and effective in improving muscle strength and function as well as muscle mass and health-related quality of life in patients with PM and DM . TRIAL REGISTRATION Clinicaltrials.gov NCT01501019 . Registered November 29 , 2011 .
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Intervention_Educational
low-intensity resistance training
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Intervention_Educational
low-intensity resistance training program
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Intervention_Physical
low-intensity ( that is , 30 % one-repetition-maximum ( 1RM ) ) resistance exercise training program
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Intervention_Physical
partial blood flow restriction ( BFR )
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Intervention_Physical
BFR
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Intervention_Physical
leg-press
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Intervention_Physical
knee-extension exercises
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Intervention_Physical
low-intensity resistance training program
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Outcome_Physical
maximal dynamic strength
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Outcome_Physical
knee-extension exercises
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Outcome_Other
timed-stands
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Outcome_Physical
timed-up-and-go test
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Outcome_Physical
Quadriceps CSA
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Outcome_Physical
Short Form-36 Health Survey , the Health Assessment Questionnaire scores , and the patient- and physician reported Visual Analogue Scale
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Outcome_Adverse-effects
self-reported adverse
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Outcome_Physical
Laboratory parameters ( creatine kinase and aldolase )
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Participant_Condition
polymyositis and dermatomyositis .
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Participant_Condition
patients with polymyositis ( PM ) and dermatomyositis ( DM )
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Participant_Sample-size
13
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Participant_Condition
with PM and DM completed