80688
document
Lower relapse rates after neighbourhood injection of Corynebacterium parvum in operable cervix carcinoma . The effect of adjuvant immunotherapy with a single neighbourhood injection of 2 mg C. parvum ( CP ) was investigated in a randomized study involving 43 patients with carcinoma of the cervix uteri , all of whom were treated by radical surgery . All patients had carcinoma confined to the cervix , the upper part of the vagina or the parametrial region . When the malignancy had spread to the parametrial region , additional postoperative radiotherapy was given . 22 patients received immunotherapy 10 days before surgery , whereas the remaining 21 control patients received no immune stimulation . Only minor side effects of CP were encountered . Follow-up shows a relapse rate of 5 % in the CP treated group and of 29 % in the controls ( P less than 0.05 ) . A further 15 patients with more advanced malignancies were added to our studies . In these , CP stimulation had no effect on relapse rates , but the relapse-free intervals were longer after immune stimulation : control 3.5 months ( mean ) +/- 1.5 ( s.d . ) , CP 13.0 months +/- 7.0 ( P less than 0.05 ) . The number of peripheral T cells and the ability to become sensitized to DNCB were increased after CP stimulation . A decrease was found in the number of blood monocytes and the number of monocytes capable of transforming into active macrophages , indicating a possible sequestration of these cells in the tissues .
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Intervention_Pharmacological
Corynebacterium parvum
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Intervention_Pharmacological
parvum ( CP )
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Intervention_Surgical
radical surgery
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Intervention_Physical
postoperative radiotherapy
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Intervention_Pharmacological
immunotherapy
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Intervention_Control
no immune stimulation
80695
Intervention_Pharmacological
CP stimulation
80696
Intervention_Pharmacological
immune stimulation
80697
Intervention_Pharmacological
CP stimulation
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Outcome_Adverse-effects
side effects
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Outcome_Physical
relapse rate
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Outcome_Physical
relapse rates
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Outcome_Physical
relapse-free intervals
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Outcome_Physical
number of peripheral T cells and the ability to become sensitized to DNCB
80703
Outcome_Physical
number of blood monocytes and the number of monocytes capable of transforming into active macrophages
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Participant_Condition
43 patients with carcinoma of the cervix uteri , all of whom were treated by radical surgery .