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document
[ Clinical observation on effect of fuzheng yiliu granule on cell cycle and nuclear transcription factor-kappa B in tissue of esophageal-gastric carcinoma ] . OBJECTIVE To observe the effect of Fuzheng Yiliu Granule ( FZYLG ) on cell cycle and nuclear transcription factor-kappa B ( NF-kappa B ) in tissue of esophageal-gastric carcinoma . METHODS Seventy-six patients with esophageal gastric carcinoma were randomly divided into two groups , the FZYLG group and the control group . FZYLG was given to the former for 15 days . The tumor tissue in both groups was resected and cell cycle and apoptosis rate as well as NF-kappa B were determined by flowcytometry . RESULTS Level of NF-kappa B in the treated group was significantly higher than that in the control group ( P < 0.05 ) . In the treated group , the percentage of G0/G1 stage cells were significantly increased and that of S stage significantly decreased ( both P < 0.05 ) . At the same time , obvious cell apoptosis was found in the treated group , the apoptosis rate of which was significantly higher than that in the control group ( P < 0.01 ) . CONCLUSION FZYLG can increase the NF-kappa B expression , block the proliferation to promote the apoptosis of tumor cells .
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Intervention_Pharmacological
fuzheng yiliu granule
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Intervention_Pharmacological
Fuzheng Yiliu Granule ( FZYLG )
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Intervention_Pharmacological
FZYLG
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Intervention_Control
control group
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Intervention_Pharmacological
FZYLG
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Intervention_Pharmacological
FZYLG
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Outcome_Physical
cell cycle
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Outcome_Physical
apoptosis rate
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Outcome_Physical
Level of NF-kappa B
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Outcome_Physical
percentage of G0/G1 stage cells
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Outcome_Physical
S stage
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Outcome_Physical
cell apoptosis
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Outcome_Physical
apoptosis
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Outcome_Physical
apoptosis