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document
Metoprolol CR/XL improves systolic and diastolic left ventricular function in patients with chronic heart failure . AIMS To investigate whether metoprolol controlled release/extended release ( CR/XL ) once daily would improve diastolic and systolic left ventricular function in patients with chronic heart failure and decreased ejection fraction . METHODS In an echocardiographic substudy to the Metoprolol CR/XL Randomized Intervention Trial in Heart Failure ( MERIT-HF ) , 66 patients were examined three times during a 12-month period blinded to treatment group , assessing left ventricular dimensions and ejection fraction , and Doppler mitral inflow parameters , all measured in a core laboratory . RESULTS In the metoprolol CR/XL group left ventricular ejection fraction increased from 0.26 to 0.31 ( P = 0.009 ) after a mean observation period of 10.6 months , and deceleration time of the early mitral filling wave ( E ) increased from 189 to 246 ms ( P = 0.0012 ) , time velocity integral of E-wave increased from 8.7 to 11.2 cm ( P = 0.018 ) , and the duration of the late mitral filling wave ( A ) increased from 122 to 145 ms ( P = 0.014 ) . No significant changes were seen in the placebo group regarding any of these variables . CONCLUSION Metoprolol CR/XL once daily in addition to standard therapy improved both diastolic and systolic function in patients with chronic heart failure and decreased ejection fraction .
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Intervention_Pharmacological
Metoprolol CR/XL
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Intervention_Pharmacological
metoprolol controlled release/extended release ( CR/XL )
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Intervention_Pharmacological
Metoprolol CR/XL
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Intervention_Pharmacological
metoprolol CR/XL
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Intervention_Control
placebo
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Intervention_Pharmacological
Metoprolol CR/XL
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Outcome_Physical
systolic and diastolic left ventricular function
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Outcome_Physical
diastolic and systolic left ventricular function
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Outcome_Physical
left ventricular dimensions and ejection fraction , and Doppler mitral inflow parameters
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Outcome_Physical
left ventricular ejection fraction
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Outcome_Physical
time of the early mitral filling wave
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Outcome_Physical
time velocity integral of E-wave
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Outcome_Physical
duration of the late mitral filling wave
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Outcome_Physical
diastolic and systolic function
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Participant_Condition
chronic heart failure
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Participant_Sample-size
66