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document
Effects of the cholinomimetic SDZ ENS-163 on scopolamine-induced cognitive impairment in humans . Scopolamine-induced cognitive impairment was used in healthy men to evaluate the central nervous system activity of the new cholinomimetic SDZ ENS-163 . Eighteen subjects were treated in a crossover design with oral placebo/intravenous saline , 50 mg of oral SDZ ENS-163/intravenous saline , oral placebo/0.4 mg of intravenous scopolamine , and 50 mg of oral SDZ ENS-163/0.4 mg of intravenous scopolamine . The administration of placebo with scopolamine caused significant cognitive impairment , as assessed by the Computerized Neuropsychological Test Battery ( CNTB ) , and also decreased salivation and heart rate . In contrast , SDZ ENS-163 with saline had no effect on CNTB scores , increased salivation , and increased heart rate . Despite the observed cholinomimetic effects of SDZ ENS-163 when administered with saline , the changes in CNTB scores , heart rate , and salivation were indistinguishable between placebo/scopolamine and SDZ ENS-163/scopolamine . Thus , 50 mg of oral SDZ ENS-163 has cholinomimetic activity in normal men , but this dose is insufficient to reverse the muscarinic effects of 0.4 mg of intravenous scopolamine .
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Intervention_Pharmacological
cholinomimetic SDZ ENS-163
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Intervention_Pharmacological
new cholinomimetic SDZ ENS-163
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Intervention_Control
oral placebo/intravenous saline
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Intervention_Pharmacological
50 mg of oral SDZ ENS-163/intravenous saline
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Intervention_Control
oral placebo/0.4 mg of intravenous scopolamine
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Intervention_Pharmacological
50 mg of oral SDZ ENS-163/0.4 mg of intravenous scopolamine
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Outcome_Physical
cognitive impairment
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Outcome_Physical
significant cognitive impairment
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Outcome_Mental
Computerized Neuropsychological Test Battery ( CNTB )
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Outcome_Physical
decreased salivation and heart rate
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Outcome_Mental
CNTB scores
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Outcome_Physical
increased salivation
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Outcome_Physical
increased heart rate
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Outcome_Physical
cholinomimetic effects
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Outcome_Mental
changes in CNTB scores
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Outcome_Physical
heart rate
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Outcome_Physical
salivation
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Outcome_Physical
cholinomimetic activity
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Outcome_Physical
muscarinic effects
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Participant_Condition
Scopolamine-induced cognitive impairment was used in healthy men