78723
document
Comparison of short-term efficacy of diltiazem and propranolol in unstable angina at rest -- a randomized trial in 70 patients . The short-term efficacy of diltiazem ( D ) has been compared to that of propranolol ( P ) , in a group of 70 patients hospitalized in the Coronary Care Unit for unstable angina , defined as recent ( less than one month ) appearance or aggravation of spontaneous chest pains . Among the 70 patients , 24 had angina only at rest . The patients have been divided into two groups according to ST-T changes during chest pain : 29 with ST elevation ( group A ) and 41 with other repolarization abnormalities ( group B ) . Treatment was then randomized in each group . Treatment Treatment was considered successful only if spontaneous chest pains disappeared completely . Thirty-four patients were treated with D ( 282 +/- 102 mg/day ) and 36 with P ( 158 +/- 81 mg/day ) . In the whole group and in groups A and B considered individually , responses to D and P did not differ . Among the 24 patients with angina exclusively at rest , nine successes and four failures were observed with D. There was no symptomatic relief among the 11 patients treated by P ( P = 0.001 ) . Moreover , the number of episodes of angina was decreased by D and unchanged by P , while eight out of the 11 failures with P were immediate successes when treatment was replaced with D. These results suggest that D is preferable to P for management of unstable angina in patients with angina which is exclusively spontaneous .
78724
Intervention_Pharmacological
diltiazem and propranolol
78725
Intervention_Pharmacological
diltiazem ( D )
78726
Intervention_Pharmacological
propranolol ( P )
78727
Intervention_Pharmacological
D
78728
Intervention_Pharmacological
P
78729
Intervention_Pharmacological
D
78730
Intervention_Pharmacological
P
78731
Intervention_Pharmacological
D.
78732
Intervention_Pharmacological
P
78733
Intervention_Pharmacological
D
78734
Intervention_Pharmacological
P
78735
Intervention_Pharmacological
P
78736
Intervention_Pharmacological
D.
78737
Intervention_Pharmacological
D
78738
Intervention_Pharmacological
P
78739
Outcome_Physical
chest pains
78740
Outcome_Physical
angina
78741
Outcome_Physical
no symptomatic relief
78742
Outcome_Physical
number of episodes of angina
78743
Participant_Sample-size
70
78744
Participant_Sample-size
70
78745
Participant_Condition
unstable angina
78746
Participant_Condition
chest pains .
78747
Participant_Sample-size
70
78748
Participant_Sample-size
24
78749
Participant_Condition
angina
78750
Participant_Condition
chest pain
78751
Participant_Sample-size
29
78752
Participant_Sample-size
41
78753
Participant_Condition
repolarization abnormalities ( group B )
78754
Participant_Sample-size
24
78755
Participant_Condition
angina
78756
Participant_Condition
angina
78757
Participant_Condition
angina