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document
Impact of angiotensin II receptor blocker therapy ( olmesartan or valsartan ) on coronary atherosclerotic plaque volume measured by intravascular ultrasound in patients with stable angina pectoris . Coronary plaques can be reduced by some medications . The aim of this study was to compare the effects of 2 angiotensin II receptor blockers ( olmesartan at 20 mg/day or valsartan at 80 mg/day ) on coronary plaque by coronary intravascular ultrasound . One hundred hypertensive patients with stable angina pectoris who underwent elective percutaneous coronary intervention were randomly selected to receive 1 of the 2 angiotensin II receptor blockers after coronary intervention . Nontarget coronary lesions with mild to moderate stenosis were measured by volumetric intravascular ultrasound at baseline and after 6 months . After 6 months , both the olmesartan and the valsartan groups showed significant reduction of the examined coronary plaque volume ( 46.2 ± 24.1 mm³ at baseline vs 41.6 ± 21.1 mm³ at 6 months : 4.7 % decrease , p = 0.0002 ; and 47.2 ± 32.7 mm³ at baseline vs 42.5 ± 30.2 mm³ at 6 months : 4.8 % decrease , p = 0.002 , respectively ) . There was no statistically significant difference of plaque regression between the 2 groups ( p = 0.96 ) . In conclusion , there was a significant decrease from baseline in the coronary plaque volume in patients with stable angina pectoris who received olmesartan or valsartan for 6 months . In addition , there was no significant difference in the reduction of plaque volume achieved by these 2 medications .
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Intervention_Pharmacological
angiotensin II receptor blocker therapy
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Intervention_Pharmacological
olmesartan
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Intervention_Pharmacological
valsartan
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Intervention_Pharmacological
olmesartan
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Intervention_Pharmacological
valsartan
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Intervention_Pharmacological
olmesartan
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Intervention_Pharmacological
valsartan
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Outcome_Physical
Nontarget coronary lesions with mild to moderate stenosis
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Outcome_Physical
examined coronary plaque volume
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Participant_Condition
stable angina pectoris
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Participant_Sample-size
One hundred
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Participant_Condition
hypertensive
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Participant_Condition
stable angina pectoris