30607
document
[ Comparison of three analgesic methods for postoperative pain relief and their effects on plasma interleukin-6 concentration following radical surgery for gastric carcinoma ] . OBJECTIVE To compare the efficacy of preemptive epidural analgesia combined with postoperative epidural analgesia , postoperative epidural analgesia alone and intravenous analgesia for postoperative pain relief and their effects on plasma interleukin-6 ( IL-6 ) concentration following radical surgery for gastric carcinoma . METHODS Sixty-six patients with gastric carcinoma scheduled for gastrectomy were randomly divided into 3 groups , namely group P ( n=22 ) , group E ( n=22 ) and group V ( n=22 ) , to receive preemptive epidural analgesia combined with postoperative epidural analgesia , exclusive postoperative epidural analgesia , and exclusive postoperative intravenous analgesia , respectively . Hemodynamic data were recorded for all the patients during the operation , and visual analogue scale ( VAS ) was used to assess the pain intensity at 4 , 8 , 16 , 24 , 48 and 72 h after surgery . Plasma IL-6 concentration was determined before surgery and at 24 , 48 , 72 h after surgery . RESULTS No significant changes occurred in the hemodynamics during the preoperative periods . VAS and IL-6 were lower in group P than in group E and V , and group E had lower measurement than group V ( P < 0.05 ) . CONCLUSION Preemptive epidural analgesia combined with postoperative epidural analgesia provides more satisfactory pain relief and more effectively prevents IL-6 increment than exclusive epidural analgesia or intravenous analgesia after gastrectomy for gastric carcinoma .
30608
Intervention_Pharmacological
preemptive epidural analgesia combined with postoperative epidural analgesia
30609
Intervention_Pharmacological
postoperative epidural analgesia alone
30610
Intervention_Pharmacological
intravenous analgesia
30611
Intervention_Pharmacological
preemptive epidural analgesia combined with postoperative epidural analgesia
30612
Intervention_Pharmacological
exclusive postoperative epidural analgesia
30613
Intervention_Pharmacological
exclusive postoperative intravenous analgesia
30614
Outcome_Physical
plasma interleukin-6 concentration
30615
Outcome_Pain
postoperative pain relief
30616
Outcome_Physical
plasma interleukin-6 ( IL-6 ) concentration
30617
Outcome_Physical
Hemodynamic data
30618
Outcome_Other
visual analogue scale ( VAS )
30619
Outcome_Pain
pain intensity
30620
Outcome_Physical
Plasma IL-6 concentration
30621
Outcome_Other
VAS
30622
Outcome_Physical
IL-6
30623
Outcome_Pain
pain relief
30624
Outcome_Physical
IL-6 increment
30625
Participant_Condition
postoperative pain
30626
Participant_Condition
gastric carcinoma
30627
Participant_Sample-size
Sixty-six