82210
document
[ Effects of betamethasone on neuromuscular blockade induced by vecuronium in continuous infusion ] . The aim of the study was to determine a possible interaction between a corticosteroid ( betamethasone ) and vecuronium , a nondepolarizing muscle relaxant . The authors studied 20 patients , ASA I-II , aged 20-54 , both sexes , scheduled for abdominal surgery . Mechanomyographic and clinical evaluation by single twitch and TOF stimulation of the ulnar nerve at the wrist and measurement of the concomitant abductor pollicis muscle was applied . The onset time of vecuronium after a single bolus dose of 0.08 mg/kg , duration of action to 10 % single twitch recovery , duration of continuous infusion of 0.4-0.5 micrograms/kg/min of vecuronium started at 10 % single twitch recovery , and the effects of 0.1 mg/kg betamethasone administration 10 min after continuous infusion were evaluated . The recovery rate of vecuronium after stopping infusion at 10 % recovery was also evaluated . Corticosteroids may interact with non-depolarizing muscle relaxants both in prejunctional and postjunctional acetylcholine receptors by several mechanisms of action .
82211
Intervention_Pharmacological
betamethasone
82212
Intervention_Pharmacological
vecuronium
82213
Intervention_Pharmacological
corticosteroid ( betamethasone ) and vecuronium
82214
Intervention_Pharmacological
nondepolarizing muscle relaxant
82215
Intervention_Surgical
abdominal surgery .
82216
Intervention_Pharmacological
vecuronium
82217
Intervention_Pharmacological
vecuronium
82218
Intervention_Pharmacological
betamethasone
82219
Intervention_Pharmacological
vecuronium
82220
Intervention_Pharmacological
Corticosteroids
82221
Outcome_Physical
neuromuscular blockade
82222
Outcome_Physical
Mechanomyographic and clinical evaluation by single twitch
82223
Outcome_Physical
TOF stimulation of the ulnar nerve at the wrist
82224
Outcome_Physical
concomitant abductor pollicis muscle
82225
Outcome_Other
onset time
82226
Outcome_Other
duration of action
82227
Outcome_Physical
single twitch recovery
82228
Outcome_Physical
single twitch recovery
82229
Outcome_Physical
recovery rate of vecuronium
82230
Participant_Condition
20
82231
Participant_Age
20-54
82232
Participant_Condition
both sexes
82233
Participant_Condition
abdominal surgery