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Baseline distribution of participants with depression and impaired quality of life in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial . BACKGROUND Previous studies have demonstrated the psychosocial effect of heart failure in patients with reduced ejection fraction . However , the effects on patients with preserved ejection fraction have not yet been elucidated . This study aimed to determine the baseline characteristics of participants with heart failure with preserved ejection fraction as it relates to impaired quality of life ( QOL ) and depression , identify predictors of poor QOL and depression , and determine the correlation between QOL and depression . METHODS AND RESULTS Among patients enrolled in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial ( TOPCAT ) , 3400 patients completed the Kansas City Cardiomyopathy Questionnaire , 3395 patients completed European QOL 5D Visual Analog Scale , and 1431 patients in United States and Canada completed the Patient Health Questionnaire-9 . The mean summary score on the Kansas City Cardiomyopathy Questionnaire was 54.8 , and on European QOL 5D Visual Analog Scale , it was 60.3 ; 27 % of patients had moderate to severe depression . Factors associated with better Kansas City Cardiomyopathy Questionnaire and European QOL 5D Visual Analog Scale via multiple logistic regression analysis were American region , older age , no history of angina pectoris or asthma , no use of hypoglycemic agent , more activity level , and lower New York Heart Association class . Factors associated with depression via multiple logistic regression analysis included younger age , female sex , comorbid angina , chronic obstructive pulmonary disease , use of a hypoglycemic agent , lower activity level , higher New York Heart Association class , and selective serotonin reuptake inhibitor use . There were significant correlations between each of the QOL scores and depression . CONCLUSIONS Patients with heart failure with preserved ejection fraction , who were younger had higher New York Heart Association class or comorbid angina pectoris , had lower activity levels , lived in Eastern Europe or were taking hypoglycemic agents , were more likely to have impaired QOL and depression . CLINICAL TRIAL REGISTRATION URL : http : //www.clinicaltrials.gov . Unique identifier : NCT00094302 .
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Intervention_Pharmacological
Aldosterone Antagonist Trial ( TOPCAT )
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Intervention_Physical
European QOL 5D Visual Analog Scale
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Outcome_Physical
Kansas City Cardiomyopathy Questionnaire
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Outcome_Physical
European QOL 5D Visual Analog Scale
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Outcome_Physical
Patient Health Questionnaire-9 .
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Outcome_Physical
Kansas City Cardiomyopathy Questionnaire
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Outcome_Physical
European QOL 5D Visual Analog Scale
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Outcome_Physical
Kansas City Cardiomyopathy Questionnaire
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Outcome_Physical
European QOL 5D Visual Analog Scale
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Outcome_Other
QOL scores
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Outcome_Other
depression
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Participant_Condition
depression
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Participant_Condition
impaired quality of life
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Participant_Condition
patients with reduced ejection fraction .
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Participant_Condition
heart failure
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Participant_Condition
preserved ejection fraction
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Participant_Condition
Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial ( TOPCAT
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Participant_Sample-size
3400 patients
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Participant_Condition
heart failure
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Participant_Age
younger
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Participant_Condition
impaired QOL and depression