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document
Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting . BACKGROUND This study was designed to evaluate transcutaneous electrical acupoint stimulation ( acustimulation ) using the ReliefBand compared with ondansetron for the treatment of established postoperative nausea and vomiting ( PONV ) after outpatient laparoscopic surgery . METHODS After the authors obtained institutional review board approval and written informed consent , 268 outpatients were enrolled in this randomized , double-blind , placebo- and sham-controlled study . All patients received antiemetic prophylaxis with metoclopramide , 10 mg intravenously , or droperidol , 0.625 mg intravenously , after induction of anesthesia . A total of 90 patients developed PONV in the recovery units and were randomized to one of three treatment groups : ( 1 ) the ondansetron group received 4 mg intravenous ondansetron and a sham ReliefBand ; ( 2 ) the acustimulation group received 2 ml intravenous saline and a ReliefBand ; and ( 3 ) the combination group received 4 mg intravenous ondansetron and a ReliefBand . A rescue antiemetic ( 10 mg intravenous metoclopramide ) was administered only if the PONV symptoms persisted for 15 min or longer after initiating the treatment . A blinded observer recorded the recovery times , emetic symptoms , rescue antiemetics , maximum nausea scores , complete response to study treatment , and time to achieve discharge criteria . Postdischarge side effects , as well as patient satisfaction and quality of recovery scores , were assessed at 24 and 72 h after surgery . RESULTS The combination group had a significantly higher complete response rate than the acustimulation group ( 73 % vs.40 % , P < 0.01 ) . In addition , fewer patients ( 8 vs. 18 ) in the combination ( vs. acustimulation ) group experienced subsequent emetic events ( P < 0.03 ) . However , there were no significant differences between the three groups with respect to patient satisfaction and quality of recovery scores . CONCLUSIONS Acustimulation with the ReliefBand can be used as an alternative to ondansetron for the treatment of established PONV . However , the use of ondansetron ( 4 mg intravenously ) in combination with the ReliefBand device improved the complete response rate to the acustimulation therapy .
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Intervention_Pharmacological
4 mg intravenous ondansetron and a sham ReliefBand
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Intervention_Pharmacological
2 ml intravenous saline and a ReliefBand
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Intervention_Pharmacological
4 mg intravenous ondansetron and a ReliefBand
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Intervention_Pharmacological
rescue antiemetic ( 10 mg intravenous metoclopramide
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Outcome_Mental
recovery times ,
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Outcome_Physical
emetic symptoms
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Outcome_Mental
,
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Outcome_Physical
rescue antiemetics
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Outcome_Mental
,
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Outcome_Physical
maximum nausea scores
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Outcome_Mental
, complete response to study treatment , and time to achieve discharge criteria .
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Outcome_Mental
complete response
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Outcome_Mental
subsequent
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Outcome_Physical
emetic events
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Outcome_Other
patient satisfaction and quality of recovery scores .
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Participant_Condition
established postoperative nausea and vomiting .
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Participant_Condition
treatment of established postoperative nausea and vomiting ( PONV ) after outpatient laparoscopic surgery .
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Participant_Sample-size
268
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Participant_Sample-size
90
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Participant_Condition
PONV
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Participant_Condition
established PONV .