78759
document
Effect of cicloxilic acid on bile lipid composition in patients with gallstones : a multicenter trial . 24 gallstone patients were treated with cicloxilic acid , an agent endowed with choleretic activity , at the dose of 240 mg/day for 1 month . 24 comparable patients on placebo treatment acted as controls . Bile lipid composition was determined and the saturation index calculated before and after treatment , on samples collected by duodenal siphonage after caerulein stimulation , in both groups . In the cicloxilic group there was little or no change in bile salts and phospholipids , whereas biliary cholesterol concentration was significantly reduced ( p less than 0.05 ) and consequently the lithogenic index lowered ( from 1.5 to 1.2 , p less than 0.01 ) . Cicloxilic acid can have a place in gallstone disease therapy in association with the litholytic bile acids or in the prevention of gallstone formation in high-risk populations .
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Intervention_Pharmacological
cicloxilic acid
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Intervention_Pharmacological
cicloxilic acid
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Intervention_Control
placebo
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Outcome_Physical
bile lipid composition
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Outcome_Physical
Bile lipid composition
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Outcome_Physical
bile salts and phospholipids
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Outcome_Physical
biliary cholesterol concentration
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Outcome_Physical
lithogenic index
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Outcome_Physical
gallstone formation
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Participant_Condition
gallstones
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Participant_Sample-size
24
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Participant_Condition
gallstone patients
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Participant_Sample-size
24
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Participant_Condition
comparable patients on placebo treatment