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Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention . OBJECTIVE Weight losses in lifestyle interventions are variable , yet prediction of long-term success is difficult . The utility of using various weight loss thresholds in the first 2 months of treatment for predicting 1-year outcomes was examined . METHODS Participants included 2327 adults with type 2 diabetes ( BMI:35.8 ± 6.0 ) randomized to the intensive lifestyle intervention ( ILI ) of the Look AHEAD trial . ILI included weekly behavioral sessions designed to increase physical activity and reduce caloric intake . 1-month , 2-month , and 1-year weight changes were calculated . RESULTS Participants failing to achieve a ≥2 % weight loss at Month 1 were 5.6 ( 95 % CI:4.5 , 7.0 ) times more likely to also not achieve a ≥10 % weight loss at Year 1 , compared to those losing ≥2 % initially . These odds were increased to 11.6 ( 95 % CI:8.6 , 15.6 ) when using a 3 % weight loss threshold at Month 2 . Only 15.2 % and 8.2 % of individuals failing to achieve the ≥2 % and ≥3 % thresholds at Months 1 and 2 , respectively , go on to achieve a ≥10 % weight loss at Year 1 . CONCLUSIONS Given the association between initial and 1-year weight loss , the first few months of treatment may be an opportune time to identify those who are unsuccessful and utilize rescue efforts . TRIAL REGISTRATION clinicaltrials.gov Identifier : NCT00017953 .
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Outcome_Physical
early weight loss
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Outcome_Physical
increase physical activity
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Outcome_Physical
reduce caloric intake
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Outcome_Physical
1-year weight changes
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Outcome_Physical
achieve a ≥2 % weight loss at Month
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Outcome_Physical
a ≥10 % weight loss at
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Outcome_Physical
using a 3 % weight
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Outcome_Physical
on to achieve a ≥10 % weight
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Outcome_Physical
1-year
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Participant_Sample-size
2327
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Participant_Age
adults
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Participant_Condition
type 2 diabetes