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document
Conservative surgery with and without radiotherapy in elderly patients with early-stage breast cancer : a prospective randomised multicentre trial . Breast conserving therapy ( BCT ) including postoperative irradiation of the remaining breast tissue is generally accepted as the best treatment for the majority of patients with early-stage breast cancer . The question is whether there is a necessity for irradiating all patients . Between 2001 and 2005 , 749 women aged 55-75 years with infiltrating breast carcinoma were randomly assigned to breast conservative surgery , with or without radiotherapy ( RT ) , to evaluate the incidence of in-breast recurrence ( IBR ) . After 5 years of median follow-up , the cumulative incidence of IBR was 2.5 % in the surgery-only arm and 0.7 % in the surgery plus RT arm . There are no differences in terms of overall survival and distant disease-free survival . The preliminary evaluation suggests that breast irradiation after conservative surgery can be avoided without exposing these patients to an increased risk of distant-disease recurrence . Prolonged follow-up will further clarify the possible risks and late sequelae potentially induced by breast RT .
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Intervention_Surgical
Breast conserving therapy ( BCT )
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Intervention_Surgical
breast conservative surgery , with or without
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Intervention_Physical
radiotherapy
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Outcome_Physical
incidence of in-breast recurrence ( IBR )
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Outcome_Physical
cumulative incidence of IBR
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Outcome_Other
no differences
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Outcome_Mortality
overall survival
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Outcome_Mortality
distant disease-free survival
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Outcome_Physical
risk of distant-disease recurrence
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Participant_Age
elderly patients
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Participant_Condition
breast cancer
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Participant_Condition
breast cancer
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Participant_Sex
women
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Participant_Age
55-75 years
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Participant_Condition
breast carcinoma