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document
An assessment of beta-adrenoceptor blockade in man by prizidilol hydrochloride . 1 Prizidilol hydrochloride ( SK & F 92657 ) is a new compound which causes both arteriolar dilatation and beta-adrenoceptor blockade . The effect of a single oral dose on the responses of heart rate and blood pressure to isoprenaline infusion has been studied in healthy volunteers . 2 Isoprenaline heart rate dose-response curves showed parallel shifts to the right after oral prizidilol , indicating antagonism by this compound at beta-adrenoceptors in the heart . 3 Isoprenaline dose-response curves for decreases in diastolic blood pressure also showed shifts to the right after oral prizidilol , providing evidence of beta-adrenoceptor antagonism by this drug in peripheral resistance vessels . 4 The peak effect of a 40 mg dose of propranolol was greater than that of a 200 mg dose of prizidilol but both drugs caused persistent beta-adrenoceptor blockade for at least 7 h after ingestion .
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Intervention_Pharmacological
prizidilol hydrochloride .
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Intervention_Pharmacological
Prizidilol hydrochloride
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Intervention_Pharmacological
Isoprenaline
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Intervention_Pharmacological
prizidilol
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Intervention_Pharmacological
prizidilol
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Intervention_Pharmacological
propranolol
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Intervention_Pharmacological
prizidilol
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Outcome_Physical
beta-adrenoceptor blockade .
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Outcome_Physical
heart rate dose-response curves
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Outcome_Physical
diastolic blood pressure
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Outcome_Physical
beta-adrenoceptor blockade
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Participant_Condition
healthy volunteers