24441
document
The evaluation of pulmonary hypertension using right ventricular myocardial isovolumic relaxation time . Right ventricular ( RV ) blood pool-derived isovolumic relaxation time ( IVRT ) correlates well with systolic pulmonary arterial pressure ( PAP ) . However , because of complex parameter derivation , the method is rarely used . The aim of this study was to validate the measurement of myocardial velocity imaging-derived RV IVRT ( IVRT ' ) against invasively measured PAP . Transthoracic echocardiography with myocardial velocity imaging and right heart catheterization were performed in 33 patients with pulmonary hypertension . Blood pool IVRT and myocardial IVRTs for the tricuspid valve annulus ring , basal and apical RV free wall segments were measured and compared with data from 33 age- and sex-matched control subjects . Measured IVRTs were significantly longer in patients with pulmonary hypertension than in control subjects . The strongest correlation ( R = 0.74 , P < .0001 ) was found between systolic PAP and the heart rate-corrected IVRT ' derived from the basal RV free wall segment . The basal segment IVRT ' corrected for heart rate correlates well with the invasive PAP measurement and , therefore , can be used to predict systolic PAP . It can even be considered as an alternative to tricuspid regurgitation-derived PAP systolic when tricuspid regurgitation is nonrecordable . A proposed method to derive systolic PAP should be used while screening the patients at risk for pulmonary hypertension , monitoring the disease progression and the effect of treatment .
24442
Intervention_Physical
right ventricular myocardial isovolumic relaxation time
24443
Intervention_Physical
RV IVRT ( IVRT ' )
24444
Intervention_Surgical
invasively measured PAP .
24445
Intervention_Physical
Transthoracic echocardiography with myocardial velocity imaging and
24446
Intervention_Surgical
right heart catheterization
24447
Outcome_Physical
Blood pool IVRT and myocardial IVRTs for the tricuspid valve annulus ring , basal and apical RV free wall segments
24448
Outcome_Physical
Measured IVRTs
24449
Outcome_Physical
systolic PAP
24450
Outcome_Physical
heart rate-corrected IVRT
24451
Outcome_Physical
basal segment IVRT
24452
Outcome_Physical
heart rate
24453
Outcome_Physical
systolic PAP
24454
Participant_Sample-size
33
24455
Participant_Condition
pulmonary hypertension
24456
Participant_Sample-size
33