14571
document
Isoflurane and propofol for long-term sedation in the intensive care unit . A crossover study . Propofol and isoflurane have been reported recently to offer better sedation than alternative agents in patients who require long-term ventilation in the Intensive Care Unit . This is the first report of a direct comparison between propofol and isoflurane . Twenty-four patients predicted to require artificial ventilation for at least 48 h were entered into a randomised crossover study to monitor sedation quality and time to recovery from sedation . There were no significant differences between the two agents in either end-point , with over 95 % optimal sedation achieved by the use of each drug . Few adverse events were noted . Technological advances in the administration of volatile agents as long-term sedatives in the Intensive Care Unit may facilitate their more widespread use .
14572
Intervention_Pharmacological
Propofol
14573
Intervention_Pharmacological
isoflurane
14574
Intervention_Pharmacological
propofol
14575
Intervention_Pharmacological
isoflurane
14576
Outcome_Other
sedation
14577
Outcome_Other
sedation quality
14578
Outcome_Other
time to recovery from sedation
14579
Outcome_Other
optimal sedation
14580
Outcome_Adverse-effects
adverse events
14581
Participant_Condition
who require long-term ventilation in the Intensive Care Unit
14582
Participant_Sample-size
Twenty-four
14583
Participant_Condition
require artificial ventilation for at least 48 h