91975
document
Effect of aldose reductase inhibition on cardiovascular reflex tests in patients with definite diabetic autonomic neuropathy over a period of 2 years . The potential of the aldose reductase inhibitor tolrestat to ameliorate definite diabetic autonomic neuropathy ( DAN ) , as defined by standard cardiovascular autonomic function tests , was evaluated in 35 patients over a period of 2 years , with repeated measurements at 3-month intervals . The effect of tolrestat ( 200 mg a day ) was compared with that of placebo on 35 controls with diabetes mellitus , of similar age , gender , and glycemic control . In the placebo group , a significant deterioration of the indices , with the exception of Valsalva ratio , was recorded , while tolrestat induced a significant beneficial change in the values of most standard cardiovascular reflex tests , in comparison to baseline and placebo . The deep breathing tests ( expiration-inspiration ratio , standard deviation , and mean circular resultant of R-R intervals ) , postural index , and postural hypotension were favorably affected . Three of 35 patients on tolrestat ( 8.6 % ) developed high transaminases levels ( more than threefold the upper normal limit ) and were withdrawn from the study . In conclusion , tolrestat improved autonomic nervous system function in patients with definite DAN , in comparison to baseline and placebo . The clinical importance of this finding needs further investigation .
91976
Intervention_Pharmacological
aldose reductase
91977
Intervention_Pharmacological
tolrestat
91978
Intervention_Pharmacological
tolrestat
91979
Intervention_Control
placebo
91980
Intervention_Control
placebo
91981
Intervention_Pharmacological
tolrestat
91982
Intervention_Pharmacological
tolrestat
91983
Intervention_Pharmacological
tolrestat
91984
Outcome_Physical
cardiovascular reflex tests
91985
Outcome_Physical
Valsalva ratio
91986
Outcome_Other
values of most standard cardiovascular reflex tests
91987
Outcome_Physical
deep breathing tests
91988
Outcome_Physical
expiration-inspiration ratio
91989
Outcome_Physical
standard deviation
91990
Outcome_Physical
mean circular resultant of R-R intervals
91991
Outcome_Physical
postural index
91992
Outcome_Physical
postural hypotension
91993
Outcome_Physical
high transaminases levels
91994
Outcome_Physical
autonomic nervous system function
91995
Participant_Condition
definite diabetic autonomic neuropathy over a period of 2 years
91996
Participant_Sample-size
35
91997
Participant_Sample-size
35
91998
Participant_Condition
controls with diabetes mellitus , of similar age , gender , and glycemic control .