86195
document
Abdominal surgical wound infection is lowered with improved perioperative enterococcus and bacteroides therapy . Perioperative antibiotics decrease surgical wound infection ( SWI ) in trauma patients requiring abdominal exploration . This investigation evaluated 24 hours of cefoxitin or ampicillin/sulbactam used for early therapy in such patients . Patients were randomly assigned to one of two treatment groups . The primary endpoint evaluated was SWI , which was defined as purulent drainage or active wound treatment . Five hundred ninety-two patients were evaluated : 283 received ampicillin/sulbactam and 309 received cefoxitin . The incidence of wound infection among the ampicillin/sulbactam patients was 2 % and among cefoxitin patients it was 7 % ( p < 0.004 ) . The cefoxitin patients with colon injuries were analyzed ( p < 0.007 ) . The major difference between the two groups was an increased incidence of enterococcal infections in the cefoxitin-treated patients . A single broad-spectrum antibiotic given for 24 hour perioperatively effectively controls SWI . Use of ampicillin/sulbactam results in a significantly lower SWI rate than use of cefoxitin , which may be a result of improved enterococcal and Bacteroides coverage .
86196
Intervention_Pharmacological
perioperative enterococcus and bacteroides therapy
86197
Intervention_Pharmacological
Perioperative antibiotics
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Intervention_Pharmacological
cefoxitin
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Intervention_Pharmacological
ampicillin/sulbactam
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Intervention_Pharmacological
ampicillin/sulbactam
86201
Intervention_Pharmacological
cefoxitin
86202
Outcome_Physical
surgical wound infection ( SWI )
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Outcome_Physical
SWI
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Outcome_Physical
incidence of wound infection
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Outcome_Physical
incidence of enterococcal infections
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Outcome_Physical
SWI rate
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Outcome_Physical
enterococcal and Bacteroides coverage .