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document
Effect of soy protein containing isoflavones on blood lipids in moderately hypercholesterolemic adults : a randomized controlled trial . BACKGROUND Dietary intake of soy protein with isoflavones may be associated with reductions in serum cholesterol . OBJECTIVES To compare the effects of a water-washed soy protein concentrate with a milk-protein based control on blood lipid levels in hyperlipidemic men and women . METHODS A randomized , double-blind , controlled clinical trial including 159 subjects . After a 3-week run-in period during which all subjects consumed a milk protein-based supplement , participants were randomized into one of two groups : a control group ( continued milk protein ) and an intervention group ( soy protein ) for a five-week period . Fasting venous blood draws for lipid measurement were obtained at baseline , towards the end of the run-in period and at the end of the intervention . Blood isoflavone concentrations were measured at the end of the study . RESULTS Blood lipid levels were not significantly different between groups at any point in time ; and there were no significant associations between blood isoflavones and lipid levels . Significant decreases in total cholesterol ( 19 mg/dL ) , and LDL-cholesterol ( 11 mg/dL ) , were observed during the run-in period , with no further decreases in lipids during the intervention period in either group . CONCLUSIONS These results do not support the hypothesis that water-washed soy protein has an effect on blood lipids . Several hypotheses are discussed , highlighting the selective nature of the effect of soy consumption in the population . The cholesterol-lowering effect during the run-in period may be explained by the " regression to the mean effect " and by other factors related to study participation , mainly nutrient displacement induced by the protein supplement .
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Intervention_Pharmacological
soy protein containing isoflavones
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Intervention_Physical
Dietary intake
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Intervention_Pharmacological
soy protein with isoflavones
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Intervention_Pharmacological
water-washed soy protein concentrate
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Intervention_Pharmacological
milk-protein based control
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Intervention_Pharmacological
milk protein-based supplement
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Intervention_Pharmacological
continued milk protein
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Intervention_Pharmacological
soy protein
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Intervention_Pharmacological
isoflavone
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Intervention_Pharmacological
isoflavones
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Intervention_Pharmacological
soy protein
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Intervention_Pharmacological
protein supplement
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Outcome_Physical
blood lipids
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Outcome_Physical
Blood isoflavone concentrations
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Outcome_Physical
Blood lipid levels
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Outcome_Physical
blood isoflavones
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Outcome_Physical
lipid levels
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Outcome_Other
decreases
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Outcome_Physical
total cholesterol
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Outcome_Physical
LDL-cholesterol
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Outcome_Physical
blood lipids
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Participant_Condition
hypercholesterolemic
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Participant_Age
adults
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Participant_Condition
hyperlipidemic
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Participant_Sex
men
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Participant_Sex
women .
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Participant_Sample-size
159