14096
document
The use of adrenocorticotrophic hormone ( 4-9 ) analog ORG 2766 in autistic children : effects on the organization of behavior . In a double-blind placebo-controlled crossover trial , 14 autistic children were treated with the neuropeptide ORG 2766 , a synthetic analog of adrenocorticotrophic hormone ( ACTH ) ( 4-9 ) . ORG 2766 treatment ( 20 mg per day during 4 weeks ) was associated with an increased amount and an improved quality of the social interaction of the autistic children with a familiar experimenter . These changes in interaction were clinically relevant . Following treatment with ORG 2766 gaze and smile behaviors of child and experimenter showed stronger temporal contingencies . Further , after ORG 2766 , stereotypies were temporally disconnected from verbal initiatives . The data supported the notion of a stimulating effect of ORG 2766 on social interaction . The implications of these findings for the endogenous opioid theory of autism are discussed .
14097
Intervention_Pharmacological
adrenocorticotrophic hormone ( 4-9 ) analog ORG 2766
14098
Intervention_Pharmacological
neuropeptide ORG 2766
14099
Intervention_Pharmacological
ORG 2766 treatment
14100
Intervention_Pharmacological
ORG 2766
14101
Intervention_Pharmacological
ORG 2766
14102
Intervention_Pharmacological
ORG 2766
14103
Outcome_Mental
gaze and smile behaviors
14104
Outcome_Mental
stronger temporal contingencies .
14105
Outcome_Mental
verbal initiatives .
14106
Participant_Condition
autistic children :
14107
Participant_Condition
14 autistic children