23623
document
Comparison of the effectiveness of oral diazepam and midazolam for the sedation of autistic patients during dental treatment . PURPOSE This study was undertaken to compare the effectiveness of oral diazepam and midazolam in sedating autistic patients during dental treatment . METHODS The treatment regimen consisted of nitrous oxide/oxygen inhalation in conjunction with oral administration of either diazepam 0.3 mg/kg or midazolam 0.5 mg/kg in a cross-over design study of 13 subjects aged 5.8 to 14.7 years . A drug was classified as being effective when over 70 % of the patients taking the drug were judged as " success " in all 3 behavioral criteria : ( 1 ) sleeping ; ( 2 ) body movement ; and ( 3 ) crying behaviors . The study was observed by an independent clinician with an intraexaminer reliability of 88 % . RESULTS For sleeping behavior , midazolam was found to be significantly more effective than diazepam as the duration of stimulation increased ( P < .05 ) . For the movement and crying behaviors , midazolam also proved to be significantly more effective from the start of treatment through the 35- and 40-min markers , respectively ( P < .05 ) . For the remainder of treatment , however , there was no statistically significant difference in these behaviors between the trials ( P > .05 ) . Diazepam and midazolam were rated as 77 % and 100 % successful , according to the overall behavior evaluation criteria ( P=.02 ) . CONCLUSIONS Both diazepam and midazolam were shown to be effective sedative agents , successfully and safely used to sedate autistic patients for dental treatment . Midazolam was significantly more effective than diazepam in those portions of the procedure with increased stimulation .
23624
Intervention_Pharmacological
diazepam
23625
Intervention_Pharmacological
midazolam
23626
Intervention_Pharmacological
diazepam
23627
Intervention_Pharmacological
midazolam
23628
Intervention_Pharmacological
nitrous oxide/oxygen inhalation
23629
Intervention_Pharmacological
oral administration of either diazepam 0.3 mg/kg or midazolam 0.5 mg/kg
23630
Outcome_Other
effectiveness
23631
Outcome_Physical
sedation
23632
Outcome_Other
effectiveness
23633
Outcome_Other
effective
23634
Outcome_Mental
sleeping behavior
23635
Outcome_Other
significantly more effective
23636
Outcome_Mental
movement and crying behaviors
23637
Outcome_Other
significantly more effective
23638
Outcome_Other
successful
23639
Outcome_Mental
behavior evaluation
23640
Outcome_Other
effective
23641
Participant_Condition
sedation of autistic patients during dental treatment .
23642
Participant_Sample-size
13
23643
Participant_Age
5.8 to 14.7 years