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document
Effects of single doses of rabeprazole 20 mg and esomeprazole 40 mg on 24-h intragastric pH in healthy subjects . OBJECTIVE To compare antisecretory effects of single doses of rabeprazole and esomeprazole . METHODS Open , randomised , 2-way crossover , clinical pharmacology study . 24 healthy subjects ( 10 men ; mean age 26.2 y ) received a single dose of rabeprazole 20 mg or esomeprazole 40 mg , with a 14-day 'washout ' . Intragastric pH was recorded continuously from 24 h before to 24 h after dosing . RESULTS Mean intragastric pH was higher after esomeprazole than rabeprazole during 0-5 h after dosing ( P=0.0001 ) ; the reverse was true from 14-24 h ( P=0.0002 ) . Mean % time pH > 3 and > 4 was greater after esomeprazole than rabeprazole during 0-14 h ( P=0.041 and 0.044 ) , but the reverse was true during 14-24 h ( P=0.0005 and 0.001 ) . In the 0-24 h interval as a whole , there was no difference between treatments in mean pH or % time pH > 3 or > 4 . CONCLUSION Single-dose rabeprazole 20 mg was as effective as esomeprazole 40 mg in increasing intragastric pH and maintaining pH > 3 and > 4 , despite the 2-fold difference in dose .
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Intervention_Pharmacological
rabeprazole
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Intervention_Pharmacological
esomeprazole
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Intervention_Pharmacological
rabeprazole
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Intervention_Pharmacological
esomeprazole .
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Intervention_Pharmacological
rabeprazole 20 mg or esomeprazole 40 mg
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Intervention_Pharmacological
esomeprazole
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Intervention_Pharmacological
rabeprazole
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Intervention_Pharmacological
esomeprazole
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Intervention_Pharmacological
rabeprazole
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Intervention_Pharmacological
rabeprazole
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Intervention_Pharmacological
esomeprazole
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Outcome_Physical
24-h intragastric pH
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Outcome_Physical
Intragastric pH
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Outcome_Physical
Mean intragastric pH
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Outcome_Physical
Mean % time pH > 3 and > 4
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Outcome_Physical
mean pH or % time pH > 3 or > 4 .
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Outcome_Physical
intragastric pH
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Outcome_Physical
pH > 3 and > 4
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Participant_Condition
24-h intragastric pH in healthy subjects .
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Participant_Sample-size
24 healthy subjects
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Participant_Age
(
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Participant_Sample-size
10
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Participant_Sex
men
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Participant_Age
; mean age 26.2 y )