80615
document
Theophylline concentrations in serum and saliva after oral microcrystalline and sustained-release preparations in asthmatics . Theophylline concentrations in saliva have been compared with those in serum in 13 asthmatic patients after single and multiple oral dosage of a microcrystalline theophylline tablet ( Nuelin ) and a sustained-release preparation ( Nuelin Retard ) . There was wide individual variation in the ratio of serum to saliva concentrations indicating that , even when individual serum to saliva ratios have been established , the use of saliva theophylline measurements alone is unreliable for the routine monitoring of theophylline therapy . Both preparations produced mean serum theophylline concentrations within the 10 -- 20 mcg/ml range , the sustained-release tablet giving higher monitoring through values and smaller through to peak variation . The preparations were equally and highly bioavailable . Side effects were reported by three patients , which were the patients with the highest AUC . The Nuelin Retard preparation appears to provide smooth , sustained serum theophylline concentrations within the therapeutic range and the simple , twice-daily dosage should result in improved patient compliance .
80616
Intervention_Pharmacological
Theophylline
80617
Intervention_Pharmacological
microcrystalline
80618
Intervention_Pharmacological
sustained-release preparations
80619
Intervention_Pharmacological
Theophylline
80620
Intervention_Pharmacological
microcrystalline theophylline tablet
80621
Intervention_Pharmacological
sustained-release preparation
80622
Intervention_Pharmacological
theophylline
80623
Intervention_Pharmacological
theophylline
80624
Intervention_Pharmacological
Nuelin Retard
80625
Outcome_Physical
Theophylline concentrations
80626
Outcome_Physical
Theophylline concentrations
80627
Outcome_Physical
ratio of serum to saliva concentrations
80628
Outcome_Physical
mean serum theophylline concentrations
80629
Outcome_Adverse-effects
Side effects
80630
Outcome_Physical
serum theophylline concentrations
80631
Participant_Condition
asthmatics
80632
Participant_Sample-size
13
80633
Participant_Condition
asthmatic