58372
document
Rifampicin plus isoniazid for the prevention of tuberculosis in an immigrant population . OBJECTIVES To compare the tolerance , adherence and effectiveness of two approaches for the treatment of latent tuberculosis infection ( LTBI ) : 6 months of isoniazid ( 6H ) vs. 3 months of isoniazid plus rifampicin ( 3RH ) . POPULATION Immigrants with LTBI . METHODS Participants were enrolled in a controlled , randomised clinical trial in Barcelona , Spain , from April 2001 to April 2005 . Monthly follow-up was done to assess tolerance , side effects and adherence . Effectiveness was evaluated at 5 years . RESULTS In the 590 subjects enrolled , the rate of adherence was greater in the 3RH than in the 6H arm ( 72 % vs. 52.4 % , P = 0.001 ) . No differences between study arms were observed with respect to hepatotoxicity or side effects . Variables associated with non-adherence were diagnosis by screening ( OR 1.88 , 95 % CI 1.26-2.82 , P = 0.001 ) , illegal immigration status ( OR 1.48 , 95 % CI 1.01-2.15 , P = 0.03 ) , unemployment ( OR 1.91 , 95 % CI 1.28-2.85 , P = 0.0008 ) , illiteracy ( OR 1.73 , 95 % CI 1.04-2.88 , P = 0.02 ) , lack of family support ( OR 3.7 , 95 % CI 2.54-5.4 , P = 0.001 ) and the 6-month treatment regimen ( OR 2.45 , 95 % CI 1.68-3.57 , P = 0.0001 ) . None of the patients who completed either treatment developed tuberculosis . CONCLUSIONS The 3RH regimen facilitates adherence to LTBI treatment and offers a safe , well-tolerated and effective alternative .
58373
Intervention_Pharmacological
Rifampicin plus isoniazid
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Intervention_Pharmacological
isoniazid ( 6H )
58375
Intervention_Pharmacological
isoniazid plus rifampicin ( 3RH )
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Intervention_Pharmacological
3RH regimen
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Outcome_Mental
rate of adherence
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Outcome_Adverse-effects
hepatotoxicity or side effects .
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Outcome_Other
screening
58380
Outcome_Other
illegal immigration status
58381
Outcome_Other
unemployment
58382
Outcome_Other
illiteracy
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Outcome_Other
lack of family support
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Outcome_Other
6-month treatment regimen
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Outcome_Adverse-effects
tuberculosis .
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Participant_Condition
Immigrants with LTBI
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Participant_Sample-size
590