87606
document
Effects of glucocorticoids on energy metabolism and food intake in humans . The effect of glucocorticoid administration on energy metabolism and food intake was studied in 20 healthy , nondiabetic Caucasian male volunteers [ 27 +/- 5 ( SD ) yr , 72 +/- 9 kg , 20 +/- 7 % body fat ] randomly and blindly assigned to glucocorticoid ( methylprednisolone , METH ; n = 10 ) or placebo ( PLAC ; n = 10 ) treatment . Each subject was studied twice : during a weight maintenance diet and during ad libitum food intake . Energy metabolism was measured by indirect calorimetry and food intake by an automated food-selection system . Twenty-four-hour urinary norepinephrine excretion ( 24-h NE ) was used as an estimate of sympathetic nervous system activity . During weight maintenance , METH intravenous infusion ( 125 mg/30 min ) increased energy expenditure compared with PLAC , and after 4 days of oral therapy , METH ( 40 mg/day ) decreased 24-h NE and increased energy expenditure compared with PLAC . During ad libitum food intake , after 4 days of METH ( 40 mg/day ) or PLAC oral therapy , both groups increased their energy intake over weight maintenance , but the increase was significantly larger in the METH group compared with the PLAC group ( 4,554 +/- 1,857 vs. 2,867 +/- 846 kcal/day ; P = 0.04 ) . Our data suggest that therapeutic doses of glucocorticoids induce obesity mostly by increasing energy intake , an effect which may be related to the ability of glucocorticoids to act directly or indirectly on the central regulation of appetite .
87607
Intervention_Pharmacological
glucocorticoids
87608
Intervention_Pharmacological
glucocorticoid
87609
Intervention_Pharmacological
glucocorticoid ( methylprednisolone , METH ;
87610
Intervention_Control
placebo ( PLAC ;
87611
Outcome_Physical
energy metabolism
87612
Outcome_Mental
food intake
87613
Outcome_Physical
energy metabolism
87614
Outcome_Mental
food intake
87615
Outcome_Physical
Energy metabolism
87616
Outcome_Mental
food intake
87617
Outcome_Physical
urinary norepinephrine excretion
87618
Outcome_Physical
sympathetic nervous system activity
87619
Outcome_Physical
energy expenditure
87620
Outcome_Physical
energy expenditure
87621
Outcome_Physical
energy intake
87622
Outcome_Physical
energy intake