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document
Effectiveness of vaginal tablets containing lactobacilli versus pH tablets on vaginal health and inflammatory cytokines : a randomized , double-blind study . The purpose of this study was to evaluate the effectiveness of lactobacilli on vaginal health and proinflammatory cytokines . Sixty-seven patients with bacterial vaginosis ( BV ) , 50 with intermediate flora and 42 with normal vaginal flora were enrolled in this double-blind study . The subjects were randomized to receive probiotic lactobacilli vaginal tablets ( L. brevis CD2 , L. salivarius subsp . salicinius , L. plantarum ) or the vaginal pH tablet ( active comparator ) . Cervico-vaginal lavage was collected to measure the concentrations of IL-1β , TNFα and IL-6 by ELISA . Neutral sphingomyelinase activity was also quantified in both arms before and after treatment . The probiotic vaginal tablet was well tolerated and no side effects were reported . The study demonstrated a cure rate of nearly 80 % ; i.e. , 32 % of the women could restore normal vaginal flora and 47 % had improved Nugent score , whereas 20 % of the subjects did not clear BV in the first follow-up ( after 8 days treatment ) . The pH tablet containing pH lowering compounds induced resolution of BV and restoration of normal vaginal flora in 74 % and 26 % , respectively . The lactobacilli tablet was found to be better than the pH tablet in preventing BV in healthy subjects . A significant reduction in IL-1β and IL-6 vaginal cytokines was observed after treatment with lactobacilli , while the active comparator did not have any effect on local proinflammatory cytokines . Vaginal neutral sphingomyelinase activity was not modified in either group . Vaginal tablets containing lactobacilli can cure BV and reduce vaginal inflammatory response .
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Intervention_Pharmacological
vaginal tablets
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Intervention_Pharmacological
lactobacilli
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Intervention_Pharmacological
pH tablets
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Intervention_Pharmacological
lactobacilli
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Intervention_Pharmacological
receive probiotic lactobacilli vaginal tablets ( L. brevis CD2 , L. salivarius subsp . salicinius , L. plantarum ) or the vaginal pH tablet ( active comparator ) .
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Outcome_Physical
vaginal health and inflammatory cytokines :
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Outcome_Physical
vaginal health and proinflammatory cytokines .
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Outcome_Physical
cure
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Outcome_Physical
resolution of BV and restoration of normal vaginal
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Outcome_Physical
preventing
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Outcome_Physical
IL-1β and IL-6 vaginal cytokines
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Outcome_Physical
Vaginal neutral sphingomyelinase
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Outcome_Physical
cure BV
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Outcome_Physical
vaginal inflammatory
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Participant_Sample-size
Sixty-seven
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Participant_Condition
bacterial vaginosis ( BV
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Participant_Sample-size
50
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Participant_Sample-size
42
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Participant_Condition
vaginal flora