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document
Comparison of succinylcholine with two doses of rocuronium using a new method of monitoring neuromuscular block at the laryngeal muscles by surface laryngeal electromyography . We compared the onset of neuromuscular block with succinylcholine ( 1 mg kg-1 ) and two doses of rocuronium ( 0.6 and 0.9 mg kg-1 ) at the adductor pollicis muscle using electromyography ( EMG ) and acceleromyography ( AMG ) , and at the adductor laryngeal muscles with a new electromyographic method using a disposable surface electrode attached to the cuff of a tracheal tube . At the larynx , the mean ( +/- SD ) time to 90 % block and the onset time of succinylcholine ( 38 +/- 15 and 47 +/- 19 s , respectively ) were significantly shorter ( P < 0.01 ) than for rocuronium 0.6 mg kg-1 ( 92 +/- 42 and 106 +/- 38 s ) and rocuronium 0.9 mg kg-1 ( 52 +/- 31 and 64 +/- 30 s ) . We found that , with comparable degrees of neuromuscular block , the onset time of succinylcholine at the adductor pollicis was significantly shorter ( P < 0.01 ) than for rocuronium 0.6 mg kg-1 and 0.9 mg kg-1 ( EMG , 80 +/- 39 vs 145 +/- 48 s and 99 +/- 31 s ; AMG , 90 +/- 39 vs 124 +/- 53 s and 106 +/- 38 s ) . Clinical duration at the adductor pollicis ( AMG ) was significantly longer ( P < 0.01 ) for both rocuronium groups than for succinylcholine ( T4 : T1 = 0.7 , 54 +/- 18 and 77 +/- 21 vs 8 +/- 6 min ) . The surface laryngeal electrode proved non-invasive , easy to use and reliable in measuring onset of the neuromuscular block at the larynx .
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Intervention_Pharmacological
succinylcholine
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Intervention_Pharmacological
rocuronium
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Intervention_Pharmacological
succinylcholine ( 1 mg kg-1 ) and two doses of rocuronium ( 0.6 and 0.9 mg kg-1 )
4360
Intervention_Other
electromyography ( EMG ) and acceleromyography
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Intervention_Other
electromyographic method
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Intervention_Pharmacological
succinylcholine
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Intervention_Pharmacological
rocuronium
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Intervention_Pharmacological
rocuronium
4365
Intervention_Pharmacological
succinylcholine
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Intervention_Pharmacological
rocuronium
4367
Intervention_Pharmacological
succinylcholine
4368
Outcome_Physical
neuromuscular block
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Outcome_Physical
onset of neuromuscular block
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Outcome_Physical
mean ( +/- SD ) time to 90 % block
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Outcome_Other
succinylcholine
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Outcome_Physical
neuromuscular block
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Outcome_Other
onset time of succinylcholine at the adductor pollicis
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Outcome_Other
Clinical duration at the adductor pollicis ( AMG )
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Outcome_Physical
onset of the neuromuscular block
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Participant_Condition
neuromuscular block at the laryngeal muscles
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Participant_Condition
surface laryngeal electromyography