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document
A double-blind randomized clinical evaluation of enamel matrix derivative proteins for the treatment of proximal class-II furcation involvements . OBJECTIVE The aim of the present randomized , double-blind study was to evaluate the clinical response of proximal furcations treated with enamel matrix derivative proteins ( EMD ) . MATERIAL AND METHODS Fifteen patients , each with a pair of contralateral class-II proximal furcation involvements , presenting probing depths ( PDs ) > /=5 mm and bleeding on probing ( BOP ) were selected . The patients were randomly assigned to : control group ( n=15 ) - open flap debridement ( OFD ) +24 % ethylenediaminetetraacetic acid ( EDTA ) conditioning ; test group ( n=15 ) - OFD+24 % EDTA conditioning+EMD application . Plaque index ( PI ) , BOP , PD , gingival margin position ( GMP ) , relative vertical and horizontal clinical attachment level ( RVCAL and RHCAL ) , vertical and horizontal bone level ( VBL and HBL ) and furcation closure were evaluated immediately before and 2 , 4 and 6 months after the surgeries . RESULTS At 6 months , the RVCAL gains of the control and test group were 0.39 +/- 1.00 and 0.54 +/- 0.95 mm , while the RHCAL gains were 1.21 +/- 2.28 and 1.36 +/- 1.26 mm ( p > 0.05 ) . The VBL and HBL gains of the control group were 1.04 +/- 1.12 and 1.00 +/- 1.79 mm , and 0.82 +/- 1.82 and 1.17 +/- 1.38 mm for the test group ( p > 0.05 ) . In addition , a statistical difference was observed in the number of the remaining class-II furcations between the test and control groups ( p < 0.05 ) in this period . CONCLUSION It may be concluded that the use of EMD in proximal furcations did not promote a superior reduction in PD or a gain in clinical and osseous attachment levels , but resulted in a higher rate of class-II to class-I furcation conversion .
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Intervention_Pharmacological
enamel matrix derivative proteins
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Intervention_Pharmacological
enamel matrix derivative proteins ( EMD )
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Intervention_Control
control group
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Intervention_Control
open flap debridement ( OFD ) +24 % ethylenediaminetetraacetic acid ( EDTA ) conditioning
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Intervention_Pharmacological
OFD+24 % EDTA conditioning+EMD application
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Intervention_Pharmacological
EMD
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Outcome_Physical
clinical response
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Outcome_Physical
Plaque index ( PI ) , BOP , PD , gingival margin position ( GMP ) , relative vertical and horizontal clinical attachment level ( RVCAL and RHCAL ) , vertical and horizontal bone level ( VBL and HBL ) and furcation closure
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Outcome_Physical
RVCAL gains
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Outcome_Physical
RHCAL
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Outcome_Physical
VBL and HBL gains
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Outcome_Physical
number of the remaining class-II furcations
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Outcome_Physical
PD
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Outcome_Physical
clinical and osseous attachment levels
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Outcome_Physical
class-II to class-I furcation conversion .
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Participant_Sample-size
Fifteen patients
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Participant_Condition
contralateral class-II proximal furcation involvements
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Participant_Condition
presenting probing depths ( PDs ) > /=5 mm
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Participant_Condition
bleeding on probing ( BOP )