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document
The short-term effects of transcranial direct current stimulation on electroencephalography in children with autism : a randomized crossover controlled trial . Abnormal synaptic maturation and connectivity are possible etiologies of autism . Previous studies showed significantly less alpha activity in autism than normal children . Therefore , we studied the effects of anodal tDCS on peak alpha frequency ( PAF ) related to autism treatment evaluation checklist ( ATEC ) . Twenty male children with autism were randomly assigned in a crossover design to receive a single session of both active and sham tDCS stimulation ( 11 mA ) over F3 ( left dorsolateral prefrontal cortex ) . Pre- to postsession changes in a measure of cortical activity impacted by tDCS ( PAF ) and ATEC were compared between groups . We also examined the associations between pre- and postsession changes in the PAF and ATEC . The results show significant pre- to postsession improvements in two domains of ATEC ( social and health/behavior domains ) following active tDCS , relative to sham treatment . PAF also significantly increased at the stimulation site , and an increase in PAF was significantly associated with improvements in the two domains of ATEC impacted by tDCS . The findings suggest that a single session of anodal tDCS over the F3 may have clinical benefits in children with autism and that those benefits may be related to an increase in PAF .
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Intervention_Physical
transcranial direct current stimulation
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Intervention_Physical
anodal tDCS
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Intervention_Physical
active and sham tDCS stimulation
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Intervention_Physical
anodal tDCS
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Outcome_Other
changes in a measure of cortical activity
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Outcome_Physical
tDCS ( PAF )
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Outcome_Physical
ATEC
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Outcome_Physical
PAF
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Outcome_Physical
ATEC .
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Outcome_Other
results show significant pre- to postsession improvements
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Outcome_Mental
two domains of ATEC ( social and health/behavior domains )
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Outcome_Other
tDCS
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Outcome_Physical
PAF
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Outcome_Other
increased
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Outcome_Physical
increase in PAF
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Outcome_Physical
ATEC
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Outcome_Physical
clinical benefits
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Outcome_Physical
PAF .
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Participant_Age
children
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Participant_Condition
autism
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Participant_Condition
autism
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Participant_Sample-size
Twenty
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Participant_Sex
male
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Participant_Age
children
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Participant_Condition
autism