44095
document
Efficacy of omeprazole versus high-dose famotidine for prevention of exercise-induced gastritis in racing Alaskan sled dogs . BACKGROUND Omeprazole and famotidine both reduce severity of exercise-induced gastritis , but administering famotidine is easier than administering omeprazole during racing competition . HYPOTHESIS Famotidine is more efficacious than no treatment in reducing severity of exercise-induced gastritis ; and high-dose famotidine is more efficacious than omeprazole in reducing severity of exercise-induced gastritis . ANIMALS Experiment 1 : Randomized placebo-controlled study , 36 sled dogs ( 3-8 years ) ; Experiment 2 : Randomized positive-control study , 52 sled dogs ( 2-8 years ) . METHODS Experiment 1 : Equal numbers of dogs randomly assigned to famotidine ( 20 mg q24h ) or no treatment groups . Gastroscopy was performed 24 hours after the dogs ran 330 miles . Mucosal appearance was blindly scored by previously described scoring system . Experiment 2 : Equal numbers of dogs randomly assigned to omeprazole ( 20 mg q24h ) or high-dose famotidine ( 40 mg q12h ) groups . Gastroscopy was performed 48 hours before and 24 hours after the dogs ran 300 miles . Mucosal appearance was blindly scored by previously described scoring system . RESULTS Famotidine reduced the prevalence of clinically relevant , exercise-induced gastric lesions compared with no treatment ( 7/16 versus 11/16 , P = .031 ) . Compared with high-dose famotidine , omeprazole significantly decreased the severity ( 0.4 versus 1.2 , P = .0002 ) and prevalence ( 2/23 versus 7/21 , P = .049 ) of gastric lesions . CONCLUSIONS AND CLINICAL RELEVANCE Although famotidine provides some benefit in the prevention of exercise-induced gastric lesions , omeprazole is superior to famotidine in preventing gastritis in dogs running 300 miles . Routine administration of omeprazole is recommended to prevent stress-associated gastric disease in exercising and racing Alaskan sled dogs .
44096
Intervention_Pharmacological
omeprazole
44097
Intervention_Pharmacological
high-dose famotidine
44098
Intervention_Pharmacological
Omeprazole
44099
Intervention_Pharmacological
famotidine
44100
Intervention_Pharmacological
famotidine
44101
Intervention_Control
no treatment
44102
Intervention_Pharmacological
omeprazole
44103
Intervention_Pharmacological
famotidine
44104
Intervention_Pharmacological
Famotidine
44105
Intervention_Pharmacological
famotidine
44106
Intervention_Pharmacological
omeprazole
44107
Intervention_Pharmacological
omeprazole
44108
Outcome_Physical
exercise-induced gastritis
44109
Outcome_Physical
Mucosal appearance
44110
Outcome_Physical
Mucosal appearance
44111
Outcome_Physical
clinically relevant , exercise-induced gastric lesions
44112
Outcome_Physical
severity
44113
Outcome_Physical
prevalence
44114
Outcome_Physical
gastric lesions .
44115
Outcome_Physical
exercise-induced gastric lesions
44116
Outcome_Physical
gastritis
44117
Outcome_Physical
stress-associated gastric disease
44118
Participant_Condition
racing Alaskan sled dogs
44119
Participant_Sample-size
36
44120
Participant_Sample-size
52