10990
document
A randomized , double-blind , placebo-controlled trial of porcine versus synthetic secretin for reducing symptoms of autism . OBJECTIVE To compare the effects of a single dose of biologic and synthetic porcine secretin to placebo on a variety of autism symptoms . METHOD Eighty-five children with autism without other medical conditions and not taking other psychotropic medications participated ( ages between 3 and 12 years , mean IQ = 55 ) . Children were grouped into trios matched by age and communication level and then randomly assigned to one of three treatment groups : biologic secretin ( 2 CU/kg ) , synthetic secretin ( 0.4 microg/kg ) , and placebo . Measures collected 1 week before and 4 weeks after infusion included autism symptoms , language skills , and problem behaviors , gathered from parents , teachers , and investigators , who were all blind to treatment . Two-factor , repeated-measures analyses of variance ( 3 treatment levels by 2 repeated measures , pre- and postinfusion ) were used to examine efficacy . RESULTS Direct observation measures did not show change over time related to secretin . Parent reports showed an overall reduction of symptom severity for all treatment groups , including the placebo group . One teacher-report measure showed decreases in autism symptoms in the placebo and synthetic secretin groups . CONCLUSIONS No evidence that either biologic or synthetic secretin provided amelioration of symptoms beyond placebo was observed . This held true when children with and without gastrointestinal problems were examined separately .
10991
Intervention_Control
placebo-controlled
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Intervention_Pharmacological
porcine
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Intervention_Pharmacological
synthetic secretin
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Intervention_Pharmacological
biologic
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Intervention_Pharmacological
synthetic porcine secretin
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Intervention_Control
placebo
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Intervention_Pharmacological
biologic secretin
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Intervention_Pharmacological
synthetic secretin
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Intervention_Control
placebo
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Intervention_Pharmacological
secretin
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
synthetic secretin
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Intervention_Pharmacological
biologic
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Intervention_Pharmacological
synthetic secretin
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Intervention_Control
placebo
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Outcome_Physical
symptoms of autism
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Outcome_Mental
autism symptoms , language skills , and problem behaviors
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Outcome_Other
gathered from parents , teachers , and investigators
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Outcome_Physical
symptom severity
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Participant_Condition
autism .
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Participant_Condition
autism
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Participant_Sample-size
Eighty-five children
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Participant_Age
ages between 3 and 12 years
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Participant_Age
children
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Participant_Condition
gastrointestinal problems