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document
Effects of sibutramine on thermogenesis in obese patients assessed via immersion calorimetry . Glucose utilization studies show that sibutramine-induced thermogenesis is mediated via selective sympathetic activation of brown adipose tissue . The goal of the present study was to use a new calorimetry method in which resting metabolic rate is enhanced to evaluate the effects of sibutramine treatment on thermogenesis . Sixty obese women were included in the study . Subjects were divided into 2 equal groups-the placebo and sibutramine treatment groups . The sibutramine group was given sibutramine 10 mg daily for 12 wk . At baseline and at the end of the 12-wk treatment period , thermogenic measurements were taken with the use of water immersion calorimetry . Subjects were examined at weeks 4 , 8 , and 12 of treatment to identify adverse effects . Body mass index , measured at 31.5+/-2.05 kg/m2 in the placebo group , decreased to 30.4+/-2.94 kg/m ( 2 ) after 12 wk ( P=.07 ) . In the sibutramine group , it decreased from 33.5+/-4.1 kg/m ( 2 ) to 30.9+/-4.8 kg/m ( 2 ) ( P < .05 ) . In the sibutramine group , mean thermogenic response changed from a baseline value of 1.27+/-0.29 kcal/kg/h to 1.44+/-0.13 kcal/kg/h after 12 wk of treatment . In the placebo group , the baseline value was 1.56+/-0.27 kcal/kg/h ; it changed to 1.33+/-0.36 kcal/kg/h at the end of 12 wk . The findings of this study suggest that sibutramine treatment promotes thermogenesis , thus facilitating weight loss . Calorimetry enhances resting metabolism through more efficient heat transfer from the body .
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Intervention_Pharmacological
sibutramine
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Intervention_Pharmacological
sibutramine-induced
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Intervention_Pharmacological
sibutramine
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Intervention_Control
placebo
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Intervention_Pharmacological
sibutramine
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Intervention_Pharmacological
sibutramine
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Intervention_Pharmacological
sibutramine
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Intervention_Pharmacological
sibutramine
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Intervention_Pharmacological
sibutramine
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Outcome_Physical
water immersion calorimetry
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Outcome_Physical
Body mass index
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Outcome_Physical
mean thermogenic response
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Outcome_Physical
thermogenesis
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Outcome_Physical
weight loss
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Outcome_Physical
resting metabolism
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Outcome_Physical
heat transfer from the body
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Participant_Condition
obese patients
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Participant_Age
Sixty obese women were included in the study .