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document
Effects of topical and systemic folic acid supplementation on gingivitis in pregnancy . A double-blind study evaluated the effects of systemic and topical folate on gingival inflammation during the fourth and eighth months of pregnancy . Thirty women were randomly divided into three groups . Group A received placebo mouthwash and tablets ; Group B ; placebo mouthwash and 5 mg folate tablets ; Group C : folate mouthwash and placebo tablets . Supplementation lasted for 14 days during months 4 and 8 . Subjects took one tablet daily and rinsed twice daily for 1 min with the mouthwash . At the start and finish of each 14-day period , fasting serum and red cell folate levels were estimated and oral status assessed by a plaque index ( P1I ) , a gingival index ( GI ) , and gingival exudate flow meter ( GEF ) . Subjects completed 1-week diet sheets which were analysed for dietary folate . All groups were similar in each parameter at the start . Correlation was demonstrated between GI and P1I , and between GI and GEF . GI tended to increase throughout pregnancy in all groups except Group C , when in the eighth month there was a highly significant improvement ( 0.001 less than P 0.01 ) despite no significant change in P1I . Although dietary intake of folate was significantly higher during the eighth month in Group C as compared with Groups A and B , ( 0.001 less than P less than 0.01 ) , the folate mouthwash produced highly significantly improvement in gingival health in pregnancy .
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Intervention_Pharmacological
topical and systemic folic acid
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Intervention_Educational
systemic and topical folate
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Intervention_Control
placebo mouthwash and tablets
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Intervention_Pharmacological
;
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Intervention_Pharmacological
placebo mouthwash and 5 mg folate tablets ;
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Intervention_Pharmacological
folate mouthwash and placebo tablets .
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Outcome_Physical
gingivitis in pregnancy .
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Outcome_Physical
gingival inflammation during the fourth and eighth months of pregnancy .
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Outcome_Physical
fasting serum and red cell folate levels
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Outcome_Physical
plaque index ( P1I ) , a gingival index ( GI ) , and gingival exudate flow meter ( GEF )
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Outcome_Physical
dietary folate
80090
Outcome_Physical
GI and P1I
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Outcome_Physical
GI and GEF
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Outcome_Physical
GI
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Outcome_Physical
gingival health
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Participant_Condition
gingival inflammation during the fourth and eighth months of pregnancy .