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document
[ Treatment of primary osteoporosis with calcium and salmon calcitonin ] . Fifty-nine consecutive patients ( 19 men , 40 women , mean age 60.8 [ 27-80 ] years ) with primary osteoporosis were studied to see if there was any significant gain in bone mass after treatment with salmon calcitonin . All the patients were given 1 g calcium by mouth every morning . Group 1 ( n = 20 ) received no other specific medication while group 2 ( n = 19 ) were given 100 I.U . calcitonin subcutaneously every second evening and group 3 ( n = 20 ) received the same dose every evening . The pain reported by the patients was subdivided into four severity grades , and analgesic consumption was recorded . In group 1 there was a nonsignificant decrease in pain , but in groups 2 and 3 there was a highly significant diminution in pain ( P less than 0.005 ) and in analgesic intake ( P less than 0.01 ) . Measurements of bone density carried out by photon absorption at the end of 12 months showed a 5.5 % increase in the distal radius in group 2 ( P = 0.0001 ) and a 7.1 % increase in group 3 ( P = 0.0001 ) , while in group 1 mineral content had decreased by 4.3 % ( nonsignificant ) . These results show that a significant gain in bone mass can be achieved by administration of calcitonin , either daily or on alternate days . The incidence of extravertebral fractures and of new or progressive vertebral deformity tended to be lower in groups 2 and 3 than in group 1 .
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Intervention_Pharmacological
calcium
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Intervention_Pharmacological
salmon calcitonin
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Intervention_Pharmacological
salmon calcitonin
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Intervention_Pharmacological
calcium
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Intervention_Pharmacological
calcitonin
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Outcome_Pain
pain
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Outcome_Other
analgesic consumption
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Outcome_Pain
pain
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Outcome_Pain
pain
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Outcome_Other
analgesic intake
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Outcome_Physical
bone density
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Outcome_Physical
distal radius
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Outcome_Physical
bone mass
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Participant_Condition
Fifty-nine consecutive patients ( 19 men , 40 women , mean age 60.8 [ 27-80 ] years ) with primary osteoporosis