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document
Effects of cooking plant oils on recurrent aphthous stomatitis : a randomized , placebo-controlled , double-blind trial . OBJECTIVE One-third of the total population seems to develop minor recurrent aphthous stomatitis ( RAS ) during their lifetime . However , well-controlled dietary intervention studies to prevent minor RAS are very rare . The objective of the present study was to investigate whether the prevalence of RAS decreased with perilla oil ( rich in alpha-linolenic acid ) . METHODS Thirty subjects ( 8 men and 22 women ) who had minor RAS at least once a month were randomly allocated to a soybean oil group or a perilla oil group in a double-blind manner ( experimental phase ) after a run-in phase of 4 mo during which subjects used a reference oil , the most popular cooking oil in Japan , or a 50/50 mixture of soybean oil and rapeseed oil . During the experimental phase , subjects were asked to use soybean oil or perilla oil as the sole cooking oil for 8 mo . Blood samples were collected at the start and end of the experimental phase for fatty acid analysis of total plasma phospholipid fraction . Occurrence and needed days for healing of minor RAS were recorded during the two phases and compared . RESULTS alpha-Linolenic acid concentrations in the plasma phospholipid fraction increased significantly in both groups during the experimental phase to a similar extent . The prevalence of minor RAS in the experimental phase decreased significantly in both groups compared with the run-in phase to a similar extent , without intergroup differences . CONCLUSION Perilla oil , which is rich in alpha-linolenic acid , was not superior to soybean oil in preventing minor RAS . There was a possibility that avoiding rapeseed oil might be beneficial for prevention of minor RAS .
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Intervention_Pharmacological
cooking plant oils
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Intervention_Pharmacological
perilla oil
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Intervention_Pharmacological
soybean oil
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Intervention_Pharmacological
perilla oil
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Outcome_Physical
Blood samples
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Outcome_Physical
Occurrence and needed days for healing of minor RAS
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Outcome_Physical
alpha-Linolenic acid concentrations in the plasma phospholipid fraction
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Outcome_Physical
minor RAS in the experimental phase decreased significantly
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Participant_Condition
recurrent aphthous stomatitis ( RAS )
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Participant_Sample-size
Thirty
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Participant_Sample-size
8
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Participant_Sex
men
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Participant_Sample-size
22
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Participant_Sex
women