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document
Prognostic value of clinical , laboratory , and histological characteristics in multiple myeloma : improved definition of risk groups . Follow-up data of 320 multiple myeloma ( MM ) patients entering the German Myeloma Treatment Group ( GMTG ) trial MM01 were analysed for factors predicting overall ( OAS ) and tumour related survival ( TRS ) . Response to primary induction chemotherapy was relevant for prognosis if a limit of 25 % tumour cell mass ( TCM ) reduction was used to separate responders from non-responders . Furthermore , TCM , histological grading of myeloma cells , degree of bone marrow infiltration , haemoglobin , platelet counts , calcium , creatinine , albumin , beta 2M , and Bence Jones proteinuria correlated to both OAS and TRS . Age was relevant for OAS only . The multivariate analysis revealed histological grading , TCM and platelets as the most reliable prognostic factors . Based on these data the Durie/Salmon classification could be improved by defining poor prognosis patients ( 50 % TRS : 16 months ) characterised by pretreatment platelets of < or = 150,000 and/or poorly differentiated myeloma cell morphology . Patients lacking both risk factors displayed 50 % survival times of 46 months in stage III and 88 months in stage II .
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Intervention_Pharmacological
the German Myeloma Treatment Group ( GMTG )
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Intervention_Pharmacological
primary induction chemotherapy
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Intervention_Educational
poor prognosis
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Outcome_Mortality
overall ( OAS ) and tumour related survival ( TRS )
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Outcome_Physical
histological grading , TCM and platelets
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Outcome_Mortality
survival times
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Participant_Condition
320 multiple myeloma ( MM ) patients entering the German Myeloma Treatment Group ( GMTG ) trial MM01
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Participant_Condition
poor prognosis patients ( 50 % TRS : 16 months ) characterised by pretreatment platelets of < or = 150,000