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Optimal vaccination program for healthy adults in China . There is still no suitable routine hepatitis B immunization strategy for adults in China . To establish an optimal vaccination schedule for healthy adults , we investigated various schedules in healthy adults . In this randomized 5143 healthy adults received 10 μg hepatitis B vaccine at 0 , 1 and 3 months ( group A ) , 0 , 1 and 6 months ( group B ) , or 0 , 1 and 12 months ( group C ) . Blood samples were collected after 1 month and 12 months after the third dose . The geometric mean titer ( GMT ) , seroconversion rate ( levels of anti-HBs ≥ 10 mIU/mL ) and high response rate ( levels of anti-HBs ≥ 100 mIU/mL ) were assayed . In our study , 2438 healthy adults finished the full vaccination program and follow-up . The seroconversion/sero-protective rate of groups A-C at one and 12 month after administration of the third vaccine dose was 100 % , 99.9 % and 97.9 % verse 64.9 % , 75.7 % and 79.0 % , respectively . GMT for anti-HBs tested in group A to C within 1 or 12 month after the third vaccination was 213.16 , 432.58 and 451.47 mIU/ml verse 22.07 , 46.70 and 56.18 mIU/ml , respectively . There were significant differences of seroconversion/sero-protective rate and GMT among the 3 groups ( p < 0.01 ) . Given the high anti-HBs seroconversion rate and GMT in all 3 groups , a flexible schedule for Hepatitis B vaccine should be recommended to adults , but 0-1-12 schedule is a better choice .
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Intervention_Pharmacological
Optimal vaccination
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Intervention_Pharmacological
hepatitis B immunization
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Intervention_Pharmacological
optimal vaccination schedule
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Outcome_Physical
Optimal vaccination
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Outcome_Physical
optimal vaccination schedule
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Outcome_Physical
Blood samples
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Outcome_Physical
The geometric mean titer ( GMT ) , seroconversion rate ( levels of anti-HBs ≥ 10 mIU/mL ) and high response rate ( levels of anti-HBs ≥ 100 mIU/mL )
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Outcome_Physical
The seroconversion/sero-protective
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Outcome_Other
respectively
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Outcome_Physical
GMT for anti-HBs
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Outcome_Physical
differences of seroconversion/sero-protective rate and
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Outcome_Physical
high anti-HBs seroconversion rate and
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Participant_Condition
healthy
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Participant_Age
adults
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Participant_Age
adults
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Participant_Condition
healthy
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Participant_Age
adults
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Participant_Condition
healthy
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Participant_Age
adults
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Participant_Sample-size
5143
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Participant_Age
adults
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Participant_Sample-size
2438