78068
document
A double blind trial of terfenadine and placebo in hay fever using a substitution technique for non-responders . A double-blind study of terfenadine and placebo in 110 patients suffering from hay fever ( confirmed by skin tests ) was conducted . A novel technique was applied using an escape envelope containing a reference drug which could be taken under controlled conditions if , after 48 hours , the patient experienced no relief . Significantly more patients on placebo opened the envelope than patients taking the active drug . Terfenadine was demonstrated to be an effective drug in hay fever and produced no more drowsiness than placebo .
78069
Intervention_Pharmacological
terfenadine
78070
Intervention_Control
placebo
78071
Intervention_Pharmacological
terfenadine
78072
Intervention_Control
placebo
78073
Intervention_Control
placebo
78074
Intervention_Pharmacological
Terfenadine
78075
Outcome_Other
relief
78076
Outcome_Mental
opened the envelope
78077
Outcome_Other
effective drug
78078
Outcome_Mental
drowsiness
78079
Participant_Sample-size
110
78080
Participant_Condition
hay fever