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document
Impact of prior pharmacotherapy on remission of psychotic depression in a randomized controlled trial . Having failed to respond to an adequate antidepressant treatment course predicts poorer treatment outcomes in patients with major depression . However , little is known about the impact of prior treatment on the outcome of major depression with psychotic features ( MDpsy ) . We examined the effect of prior treatment history on the outcome of pharmacotherapy of MDpsy in patients who participated in the STOPD-PD study , a randomized , double-blind , clinical trial comparing a combination of olanzapine plus sertraline vs. olanzapine plus placebo . The strength of treatment courses received prior to randomization was classified using a validated method . A hierarchy of outcomes was hypothesized based on treatments received prior to randomization and randomized treatment . A high remission rate was observed in subjects with a history of no prior treatment or inadequate treatment who were treated with a combination of olanzapine and sertraline . A low remission rate was observed in subjects who had previously failed to respond to an antidepressant alone and who were treated with olanzapine monotherapy . A low remission rate was also observed in subjects who had previously failed to respond to a combination of an antipsychotic and an antidepressant . Similar to patients with major depression , these results emphasize the impact of prior pharmacotherapy on treatment outcomes in patients with MDpsy .
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Intervention_Pharmacological
pharmacotherapy
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Intervention_Pharmacological
pharmacotherapy
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Intervention_Pharmacological
olanzapine plus sertraline vs.
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Intervention_Control
olanzapine plus placebo .
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Intervention_Pharmacological
olanzapine
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Intervention_Pharmacological
sertraline
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Intervention_Pharmacological
olanzapine
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Intervention_Pharmacological
pharmacotherapy
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Outcome_Physical
remission of psychotic depression
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Outcome_Physical
outcome of pharmacotherapy
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Outcome_Physical
high remission rate
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Outcome_Physical
low remission rate
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Outcome_Physical
low remission rate
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Outcome_Physical
impact of prior pharmacotherapy
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Participant_Condition
psychotic depression
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Participant_Condition
major depression
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Participant_Condition
major depression with psychotic features ( MDpsy )
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Participant_Condition
MDpsy
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Participant_Condition
MDpsy