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document
Fluticasone or montelukast in preschool wheeze : a randomized controlled trial . INTRODUCTION Approximately 30 % of children younger than 3 years experience at least 1 episode of wheezing . Antiasthmatic medication is routinely prescribed , but its effectiveness remains unclear . Our study was aimed to evaluate the effect of anti-inflammatory treatment on frequency and severity of preschool wheeze episodes ( PWEs ) . METHODS Children aged 6 to 36 months with the first up to the third PWE were randomly assigned to receive montelukast , fluticasone , or no treatment for 12 weeks . The outcome measures were the number of PWEs , the number of hospitalizations due to PWE , and the severity of respiratory symptoms . results : There were no significant differences in outcome measures between the groups . However , tobacco-exposed children treated with fluticasone had significantly fewer PWEs ( P = .01 ) . CONCLUSION Neither montelukast nor fluticasone has proven effective in the prevention of PWE recurrence . Children of smoking parents may benefit from fluticasone treatment after PWE . This observation requires confirmation in larger studies .
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Intervention_Pharmacological
Fluticasone
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Intervention_Pharmacological
montelukast
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Intervention_Pharmacological
Antiasthmatic medication
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Intervention_Pharmacological
anti-inflammatory treatment
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Intervention_Pharmacological
montelukast
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Intervention_Pharmacological
fluticasone
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Intervention_Control
no treatment
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Intervention_Pharmacological
fluticasone
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Intervention_Pharmacological
montelukast
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Intervention_Pharmacological
fluticasone
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Intervention_Pharmacological
fluticasone
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Outcome_Other
preschool wheeze episodes ( PWEs )
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Outcome_Other
number of PWEs , the number of hospitalizations due to PWE
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Outcome_Physical
the severity of respiratory symptoms
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Outcome_Other
PWEs
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Outcome_Other
PWE recurrence
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Participant_Condition
preschool wheeze :
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Participant_Age
children younger than 3 years
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Participant_Condition
preschool wheeze episodes ( PWEs ) .
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Participant_Age
Children aged 6 to 36 months with the first up to the third PWE
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Participant_Age
Children of smoking parents