74804
document
Serum C-peptide after 6 months on glibenclamide remains higher than during insulin treatment . Serum C-peptide was measured fasting and 6 minutes after glucagon ( 1 mg given intravenously ) in 49 patients with non-insulin-dependent diabetes mellitus , after 4 and 6 months of successive periods of treatment with insulin and oral hypoglycaemics ( glibenclamide and metformin ) , given in random order . Glycaemic control was not significantly different on the two treatments , but C-peptide was much higher while the patients were on glibenclamide . We conclude that glibenclamide stimulates pancreatic insulin production even after 6 months treatment .
74805
Intervention_Pharmacological
glibenclamide
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Intervention_Pharmacological
6 minutes after glucagon
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Intervention_Pharmacological
insulin and oral hypoglycaemics ( glibenclamide and metformin )
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Intervention_Pharmacological
glibenclamide
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Outcome_Physical
Serum C-peptide
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Outcome_Physical
Serum C-peptide
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Outcome_Physical
Glycaemic control
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Outcome_Physical
C-peptide
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Participant_Sample-size
49
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Participant_Condition
non-insulin-dependent diabetes mellitus