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document
Single negative colposcopy : is it enough to rule out high-grade disease ? It has been proposed that women who have a negative colposcopic examination or who have no cervical intraepithelial neoplasia ( CIN ) on colposcopic biopsy can be safely returned to routine screening with the next visit being three or five years later . We present data regarding 551 women who had colposcopy in Wales for a low-grade cytological abnormality and who were followed through Cervical Screening Wales for subsequent CIN . Of 436 women declared CIN free initially , 26 ( 6.0 % ) had high-grade CIN diagnosed on follow-up . We suggest that additional screening at an interval of less than three years should be offered to women with a negative colposcopy or a biopsy without CIN .
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Intervention_Physical
Single negative colposcopy
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Intervention_Physical
colposcopic biopsy
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Intervention_Physical
colposcopy
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Outcome_Physical
CIN free
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Outcome_Physical
high-grade CIN
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Participant_Sex
women
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Participant_Condition
negative colposcopic examination or who have no cervical intraepithelial neoplasia ( CIN ) on colposcopic biopsy
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Participant_Sample-size
551
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Participant_Sex
women
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Participant_Condition
low-grade cytological abnormality
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Participant_Condition
subsequent CIN
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Participant_Sex
women
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Participant_Condition
negative colposcopy or a biopsy without CIN