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document
Bronchodilator effect of fenoterol and ipratropium bromide in infants with acute wheezing : use of MDI with a spacer device . Twenty-eight infants admitted to Exequiel González Cortes Children 's Hospital because of acute wheezing ( AW ) were randomly assigned to three study groups . Fenoterol ( FNT ) , ipratropium bromide ( IB ) , and placebo were administered respectively to children in the different groups by means of metered dose inhalers ( MDI ) with spacers , using doses of 3 puffs every hour , for 4 hours . The degree of bronchial obstruction was assessed clinically and scored with the single-blind method every hour prior to each treatment . The criterion of a bronchodilator effect was a significant decrease in the degree of bronchial obstruction at subsequent scorings . The scores of the three groups were compared using the Student 's t test for matched samples . The same test was also applied to the independent samples for determining the superiority of one treatment , FNT or IB , over the other . The results indicated a significant decrease in the scores of the groups receiving FNT and IB ( P less than 0.05 ) ; this did not occur in the group in which placebo was used . FNT produced a more rapid and sustained effect than IB ( P less than 0.05 ) . Significant bronchodilator effect was obtained in infants with AW when repeated doses of FNT or IB were administered with MDI and spacers . This effect was significantly greater in the group treated with FNT .
74307
Intervention_Pharmacological
fenoterol
74308
Intervention_Pharmacological
ipratropium bromide
74309
Intervention_Pharmacological
Fenoterol ( FNT )
74310
Intervention_Pharmacological
ipratropium bromide ( IB )
74311
Outcome_Physical
a bronchodilator effect