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document
Differential effects on bone density of progestogen-only methods for contraception in premenopausal women . The question of differential effects on bone density by two different types of progestogen-only methods for contraception in premenopausal women was addressed . Data from a prospective randomized clinical trial among 22 premenopausal women , age 32.6 ( range 20-45 years ) , who were randomly assigned to either of two treatments with continuous progestogens for contraception were analyzed ; depot-medroxyprogesterone acetate ( DMPA ) or continuous levonorgestrel treatment with subdermal implants ( Norplant ) , respectively . Forearm bone density ( BMDprox ) increased with 2.94 % ( p = 0.006 ) in women who were prescribed levonorgestrel , which was in contrast to stable values in those prescribed depot-medroxy-progesterone acetate ; group difference at 6 months for BMDprox 3.4 % ( 95 % CI 1.3 , 5.5 ; p = 0.025 ) and BMDdist 4.1 % ( 95 % CI - 1.3 , 9.6 ; p = 0.077 ) . The changes in bone density were consistent with the changes in biochemical indices for bone metabolism ; DMPA users showed signs of increased bone turnover and users of levonorgestrel showed increased bone formation with increased levels of both alkaline phosphatase ( p = 0.004 ) and osteocalcin ( p = 0.007 ) . The findings suggest an increase in bone density during treatment with levonorgestrel and stable values during short-term administration of DMPA , in standard clinical doses for contraception .
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Intervention_Physical
progestogen-only
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Intervention_Physical
progestogen-only
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Intervention_Pharmacological
continuous progestogens
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Intervention_Pharmacological
depot-medroxyprogesterone acetate ( DMPA )
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Intervention_Control
continuous levonorgestrel treatment with subdermal implants
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Intervention_Pharmacological
depot-medroxy-progesterone acetate
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Intervention_Pharmacological
DMPA
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Intervention_Pharmacological
levonorgestrel
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Intervention_Pharmacological
DMPA
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Outcome_Physical
bone density
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Outcome_Physical
Forearm bone density ( BMDprox )
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Outcome_Physical
BMDprox
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Outcome_Physical
BMDdist
86380
Outcome_Physical
bone density
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Outcome_Physical
biochemical indices for bone metabolism
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Outcome_Physical
bone turnover
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Outcome_Physical
increased bone formation
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Outcome_Physical
bone density
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Participant_Condition
premenopausal women .