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document
Effect of mild endurance exercise training and pravastatin on peripheral vasodilatation of forearm resistance vessels in patients with coronary artery disease . BACKGROUND Improved endothelial function may contribute to the beneficial effects of cholesterol lowering therapy in patients with coronary artery disease ( CAD ) , but results of the effect of statin therapy on endothelial function are disparate in these patients . Exercise training has been reported to improve endothelial function of patients at risk of or with established CAD . The goal of the study was to compare the effect of mild exercise training or statin therapy on forearm endothelial function in CAD patients with average cholesterol levels . DESIGN AND METHODS Twenty-eight sedentary male patients with angiographically documented CAD and average pretreatment total plasma cholesterol levels ( 5.1+/-0.9 mmol/l ) aged 42-75 years were included . They were randomly assigned in a 2 : 1 order to either statin therapy ( pravastatin , 40 mg daily ) or exercise training therapy ( mild endurance exercise three or more times a week ) . The effects of 10 weeks of either treatment on endothelium-dependent and independent vasodilation of forearm resistance vessels was assessed by plethysmography . Cardiopulmonary exercise testing was performed at baseline and after 10 weeks . RESULTS Ten weeks of pravastatin therapy significantly reduced low-density lipoprotein cholesterol ( from 3.8+/-0.6 to 3.1+/-0.6 mmol/l at study end , P=0.04 ) and the ratio of total to high-density lipoprotein cholesterol ( from 4.9+/-0.8 to 3.7+/-0.7 mmol/l , P=0.002 ) . Exercise training did not significantly modify the lipid profile . Peak oxygen consumption , maximal achieved workload and exercise duration tended to improve in the exercise training group but remained unchanged in the pravastatin-treated group . Neither 10 weeks of pravastatin nor mild endurance exercise training improved endothelium-dependent or independent vasomotor function in forearm resistance vessels . CONCLUSIONS In patients with CAD and average cholesterol levels , 10 weeks of treatment with mild endurance exercise training or with pravastatin failed to improve endothelium-dependent or independent vasomotor function in forearm resistance vessels .
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Intervention_Physical
mild endurance exercise training
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Intervention_Pharmacological
pravastatin
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Intervention_Physical
Exercise training
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Intervention_Physical
mild exercise training
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Intervention_Pharmacological
statin therapy
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Intervention_Pharmacological
statin therapy ( pravastatin
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Intervention_Physical
exercise training therapy
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Intervention_Educational
( mild endurance exercise three or more times a week )
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Intervention_Physical
Cardiopulmonary exercise
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Intervention_Pharmacological
pravastatin
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Intervention_Physical
Exercise training
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Intervention_Pharmacological
pravastatin-treated
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Intervention_Pharmacological
pravastatin
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Intervention_Physical
mild endurance exercise training
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Intervention_Physical
mild endurance exercise training
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Intervention_Pharmacological
pravastatin
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Outcome_Physical
low-density lipoprotein cholesterol
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Outcome_Physical
ratio of total to high-density lipoprotein cholesterol
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Outcome_Physical
lipid profile
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Outcome_Physical
Peak oxygen consumption
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Outcome_Physical
maximal achieved workload
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Outcome_Mental
exercise duration
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Outcome_Physical
endothelium-dependent or independent vasomotor function in forearm resistance vessels
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Participant_Condition
patients with coronary artery disease .