76226
document
Antihypertensive and volume-depleting effects of mild exercise on essential hypertension . After a general clinical observation period of over 4 weeks , 20 essential hypertensive subjects ( Japanese ) were randomly divided into two groups . One group ( n = 10 ; 4 men and 6 women ; 51.4 +/- 2.8 years of age ) agreed to physical training using bicycle ergometer exercise with the intensity at blood lactate threshold for 60 minutes three times a week for 10 weeks , while the other group ( n = 10 ; 4 men and 6 women ; 51.0 +/- 2.9 years of age ) did no particular physical training and was followed once a week as the control . Changes in blood pressure , hemodynamics , and humoral factors of the exercised group were compared with values in the controls . The following significant changes were found only in the exercised group . Blood pressure was significantly ( p less than 0.01 ) reduced . Whole blood and plasma volume indices were significantly reduced ( p less than 0.05 , p less than 0.01 , respectively ) . The change in ratio of serum sodium to potassium positively correlated with the change in systolic blood pressure ( r = 0.76 , p less than 0.02 ) . Plasma norepinephrine concentrations both at rest and at the workload of blood lactate threshold during graded exercise tests were significantly reduced ( p less than 0.05 , p less than 0.02 respectively ) after 10 weeks of exercise training . The change in the resting level of plasma norepinephrine positively correlated with that in the mean blood pressure . No such changes were observed in the control group . In both groups , body weight and urinary sodium excretion showed no statistically significant changes . ( ABSTRACT TRUNCATED AT 250 WORDS )
76227
Intervention_Physical
mild exercise
76228
Intervention_Physical
physical training using bicycle ergometer exercise with the intensity at blood lactate threshold for 60 minutes three times a week for 10 weeks
76229
Intervention_Control
no particular physical training
76230
Intervention_Physical
exercise training .
76231
Outcome_Physical
blood pressure
76232
Outcome_Physical
hemodynamics
76233
Outcome_Physical
humoral factors
76234
Outcome_Physical
Blood pressure
76235
Outcome_Physical
Whole blood and plasma volume indices
76236
Outcome_Physical
systolic blood pressure
76237
Outcome_Physical
Plasma norepinephrine concentrations
76238
Outcome_Physical
resting level of plasma norepinephrine
76239
Outcome_Physical
mean blood pressure .