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document
The pulsed-dye laser as an adjuvant treatment modality in acne vulgaris : a randomized controlled single-blinded trial . BACKGROUND Acne vulgaris is the most common skin disease and can pose a substantial therapeutic challenge . Recently , several phototherapeutic modalities , most notably pulsed-dye laser ( PDL ) treatment , have been introduced , but the published results - albeit promising - are controversial . OBJECTIVES To assess the efficacy of an adjuvant PDL treatment when combined with a proven topical treatment [ fixed-combination clindamycin 1 % -benzoyl peroxide 5 % hydrating gel ( C/BPO ) ] . METHODS Eighty patients ( 38 males and 42 females , mean +/- SD age 19.7 +/- 5.9 years ) were randomized in a 1 : 2 ratio to receive C/BPO alone or in combination with PDL treatment ( wavelength 585 nm , energy fluence 3 J cm ( -2 ) , pulse duration 0.35 ms , spot size 7 mm ) . Patients were evaluated at baseline and at 2 and 4 weeks after initial treatment . The primary end points were the Investigator 's Static Global Assessment ( ISGA ) score and lesion count ; the secondary end point was the Dermatology Life Quality Index ( DLQI ) . RESULTS Both groups showed a significant improvement during observation [ ISGA 27.1 % ( C/BPO ) and 24.6 % ( C/BPO + laser ) , total lesion count 9.2 % and 9.0 % , inflammatory lesion count 36.3 % and 36.9 % , DLQI 54.5 % and 42.5 % ] , but there was no significant or otherwise appreciable difference between treatment modalities as far as the extent of improvement was concerned . Patients with more severe findings at baseline had a greater benefit from either therapy regimen . CONCLUSIONS Our findings do not support the concept of a substantial benefit of PDL treatment in acne vulgaris .
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Intervention_Surgical
pulsed-dye laser
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Intervention_Surgical
pulsed-dye laser ( PDL )
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Intervention_Surgical
PDL
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Intervention_Surgical
C/BPO alone or in combination with PDL treatment
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Intervention_Surgical
C/BPO
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Intervention_Surgical
C/BPO + laser
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Intervention_Surgical
PDL
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Outcome_Other
efficacy
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Outcome_Physical
Investigator 's Static Global Assessment ( ISGA ) score
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Outcome_Physical
lesion count ;
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Outcome_Other
Dermatology Life Quality Index ( DLQI ) .
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Outcome_Physical
observation
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Outcome_Physical
total lesion count
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Outcome_Physical
inflammatory lesion count
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Participant_Sample-size
Eighty
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Participant_Sample-size
38
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Participant_Condition
males
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Participant_Sample-size
42
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Participant_Condition
females
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Participant_Age
mean +/- SD age 19.7 +/- 5.9 years )