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document
Comparison of split-course radiation therapy and continuous radiation therapy for unresectable bronchogenic carcinoma : 5 year results . One hundred and eighty-eight patients with inoperable or unresectable bronchogenic carcinoma were stratified by cell type , TNM staging , and prior surgery and then randomized into two treatment groups : continuous radiation therapy and split-course radiation therapy . There was no difference in clinical or objective improvement in the two groups . Survival rates for cases of squamous cell carcinoma , small cell carcinoma , and adrenocarcinoma were the same after both regimens of therapy . Split-course therapy resulted in a significantly better survival rate in cases of large cell carcinoma but the number of cases was small . We doubt that the difference is clinically significant . Objective roentgenographic response was accompanied by improved survival in squamous cell carcinoma , but not in the other three cell types . Split-course radiation therapy is superior to continuous radiation therapy because it is better tolerated by the patient and because re-examination of the patient prior to the second half of split-course therapy permits the detection of new metastatic disease that has become manifest during the rest period and spares the patient the futile second half of radiation therapy .
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Intervention_Physical
split-course radiation therapy
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Intervention_Physical
continuous radiation therapy
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Intervention_Physical
continuous radiation therapy
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Intervention_Physical
split-course radiation therapy
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Outcome_Mortality
Survival rates
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Outcome_Other
Split-course therapy
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Outcome_Physical
Objective roentgenographic response
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Outcome_Mortality
improved survival
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Outcome_Other
better tolerated
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Participant_Condition
unresectable bronchogenic carcinoma
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Participant_Sample-size
One hundred and eighty-eight patients
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Participant_Condition
inoperable
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Participant_Condition
unresectable bronchogenic carcinoma