92449
document
Postoperative injection of phenylbutazone does not influence fibrinolytic shutdown . Twenty-nine patients undergoing cholecystectomy because of chronic calculous cholecystitis were randomised to receive phenylbutazone 10 mg/kg intramuscularly or a control injection ( vehicle-containing local anaesthetic ) immediately after completion of surgery . Fibrinogen and plasminogen concentrations in plasma , plasminogen activator inhibitor activity in plasma and fibrinolytic activity in concentrated euglobulins were determined before surgery and on the first , third and seventh postoperative days . Phenylbutazone delayed the postoperative rise of fibrinogen concentration and reduced the plasminogen level on the first day after surgery . Fibrinolytic activity in euglobulins was decreased after the operation in both groups . The great dispersion of the results of plasminogen activator inhibitor activity was the plausible cause of the lack of any significant difference in this variable . The postoperative fibrinolytic shutdown , reflected by the decrease of fibrinolytic activity , was unaffected by phenylbutazone . It can be speculated , however , that the decline of plasminogen concentration after surgery in patients receiving this drug was the result of its stimulatory influence on the conversion of plasminogen into plasmin .
92450
Intervention_Pharmacological
phenylbutazone
92451
Intervention_Pharmacological
phenylbutazone 10 mg/kg intramuscularly
92452
Intervention_Control
control injection
92453
Intervention_Pharmacological
Phenylbutazone
92454
Intervention_Pharmacological
phenylbutazone .
92455
Outcome_Physical
fibrinolytic shutdown
92456
Outcome_Physical
Fibrinogen and plasminogen concentrations in plasma
92457
Outcome_Physical
plasminogen activator inhibitor activity in plasma and fibrinolytic activity in concentrated euglobulins
92458
Outcome_Physical
rise of fibrinogen concentration
92459
Outcome_Physical
plasminogen level
92460
Outcome_Physical
Fibrinolytic activity in euglobulins
92461
Outcome_Physical
plasminogen activator inhibitor activity
92462
Outcome_Physical
postoperative fibrinolytic shutdown
92463
Outcome_Physical
fibrinolytic activity
92464
Outcome_Physical
plasminogen concentration
92465
Participant_Sample-size
Twenty-nine
92466
Participant_Condition
chronic calculous cholecystitis