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document
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment . AIM In the present study , the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated . METHODS Among 104 cervical cancer patients selected for the present study , 54 and 50 patients were treated with chemo- and radiotherapy respectively . Plasma Se , Zn , Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment . RESULTS The decreased levels of serum trace elements , glutathione peroxidase activity and total antioxidant capacity , and increased malondialdehyde , glutathion reductase was observed in cervical cancer patients when compared to healthy controls . The increased concentration of serum Se , Zn was observed in patients treated with chemotherapy . Simultaneously there was a significant ( P < 0.001 ) increase in glutathione peroxidase and total antioxidant capacity , and significant decrease ( P < 0.05 ) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy . CONCLUSION The results demonstrated that chemotherapy but not radiotherapy results in significant increase in the trace elements levels and antioxidant activities in blood serum of cervical cancer patients .
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Intervention_Pharmacological
selenium
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Intervention_Physical
chemo- and radiotherapy
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Intervention_Pharmacological
chemotherapy
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Intervention_Pharmacological
chemotherapy
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Intervention_Physical
radiotherapy
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Intervention_Pharmacological
chemotherapy
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Intervention_Physical
radiotherapy
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Outcome_Physical
antioxidant activity
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Outcome_Physical
serum trace elements
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Outcome_Physical
glutathione peroxidase activity and total antioxidant capacity
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Outcome_Physical
malondialdehyde , glutathion reductase
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Outcome_Physical
concentration of serum Se , Zn
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Outcome_Physical
glutathione peroxidase and total antioxidant capacity
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Outcome_Physical
malondialdehyde and glutathion reductase levels
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Outcome_Physical
trace elements levels and antioxidant activities
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Participant_Condition
cervical cancer
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Participant_Condition
cervical cancer
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Participant_Sample-size
104
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Participant_Condition
cervical cancer
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Participant_Sample-size
54
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Participant_Sample-size
50
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Participant_Condition
cervical cancer
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Participant_Condition
chemotherapy
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Participant_Condition
cervical cancer