79690
document
Immunotherapy maintenance in acute non-lymphocytic leukaemia . Between January 1975 and December 1977 , 264 adult patients with acute non-lymphocytic leukaemia entered the Australian National Leukaemia Trial . Of 251 evaluable patients , three induction regimens achieved similar complete response ( CR ) rates . CROP ( cytosine arabinoside , daunorubicin , vincristine , prednisolone ) produced CR in 41 % of patients , 7 and 3 ( cytosine arabinoside , daunorubicin ) in 42 % and 7 and 3 plus hydroxyurea in 52 % . Remission duration and survival were similar when induction regimens were compared . Forty-five patients reaching maintenance therapy were randomised to either chemo-immunotherapy ( BCG plus intradermal leukaemic blast cells ) or chemotherapy alone . The duration of CR in these two groups was almost identical , though patients receiving chemotherapy alone had prolonged survival ( median 161 weeks ) when compared to the chemo-immunotherapy group ( 84 weeks , p = 0 . 07 ) . Institutions with less developed supportive facilities reported lower CR rates ( p = 0 . 04 ) . Leucocytosis ( greater than 100 X 10 ( 9 ) /1 ) and older age ( greater than 50 years ) were associated with shortened survival . The Trial has failed to show any advantage for this form of immunotherapy .
79691
Intervention_Pharmacological
Immunotherapy
79692
Intervention_Pharmacological
CROP
79693
Intervention_Pharmacological
cytosine arabinoside
79694
Intervention_Pharmacological
daunorubicin
79695
Intervention_Pharmacological
vincristine
79696
Intervention_Pharmacological
prednisolone
79697
Intervention_Pharmacological
cytosine arabinoside
79698
Intervention_Pharmacological
daunorubicin
79699
Intervention_Pharmacological
hydroxyurea
79700
Intervention_Pharmacological
maintenance therapy
79701
Intervention_Pharmacological
chemo-immunotherapy
79702
Intervention_Pharmacological
BCG
79703
Intervention_Pharmacological
intradermal leukaemic blast cells
79704
Intervention_Pharmacological
chemotherapy
79705
Intervention_Pharmacological
chemotherapy
79706
Intervention_Pharmacological
chemo-immunotherapy
79707
Intervention_Pharmacological
immunotherapy
79708
Outcome_Physical
complete response ( CR ) rates
79709
Outcome_Physical
Remission duration
79710
Outcome_Mortality
survival
79711
Outcome_Other
duration of CR
79712
Outcome_Mortality
survival
79713
Outcome_Physical
Leucocytosis
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Participant_Condition
acute non-lymphocytic leukaemia .