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document
Ambulatory blood pressure control with bedtime aspirin administration in subjects with prehypertension . BACKGROUND Aspirin has been found to prevent angiotensin II-induced hypertension and to induce nitric oxide ( NO ) release from vascular endothelium . Low-dose aspirin has also been shown to reduce blood pressure ( BP ) when administered at bedtime , as opposed to upon awakening , in untreated hypertensive patients and high-risk pregnant women . Accordingly , we investigated the effects on ambulatory BP of aspirin administered at different times of the day in prehypertension . METHODS We studied 244 subjects with prehypertension , 43.0 +/- 13.0 years of age , randomly divided in three groups : nonpharmacological hygienic-dietary recommendations ; the same recommendations and aspirin ( 100 mg/day ) on awakening ; or the same recommendations and aspirin at bedtime . BP was measured for 48 consecutive hours before and after 3 months of intervention . RESULTS Ambulatory BP was unchanged in subjects randomized to either nonpharmacological intervention or aspirin on awakening . A significant ambulatory BP reduction was , however , observed in the subjects who received aspirin at bedtime ( decrease of 6/3 mm Hg in the 24-h mean of systolic ( SBP ) /diastolic BP ( DBP ) , respectively ; P < 0.001 ) , without changes in heart rate ( HR ) from baseline . BP was homogeneously controlled along the 24 h after bedtime aspirin administration ( 6/4 mm Hg reduction in activity mean of SBP/DBP ; 6/3 mm Hg reduction in sleep-time mean , respectively ) . CONCLUSIONS This prospective trial documents a significant effect on BP of low dose aspirin only when ingested at bedtime by prehypertensive subjects . The timed administration of low-dose aspirin could thus provide a valuable and cost-effective approach for BP control in subjects at elevated risk of developing hypertension .
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Intervention_Pharmacological
aspirin administration
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Intervention_Pharmacological
Aspirin
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Intervention_Pharmacological
aspirin
40109
Intervention_Pharmacological
aspirin
40110
Intervention_Pharmacological
aspirin
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Intervention_Pharmacological
aspirin
40112
Intervention_Physical
nonpharmacological intervention
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Intervention_Pharmacological
aspirin
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Intervention_Pharmacological
aspirin
40115
Intervention_Pharmacological
aspirin
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Intervention_Pharmacological
aspirin
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Intervention_Pharmacological
aspirin
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Outcome_Physical
blood pressure
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Outcome_Physical
blood pressure ( BP )
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Outcome_Physical
ambulatory BP
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Outcome_Physical
BP
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Outcome_Mental
Ambulatory BP
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Outcome_Mental
ambulatory BP
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Outcome_Mental
systolic ( SBP ) /diastolic BP ( DBP )
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Outcome_Physical
heart rate ( HR )
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Outcome_Mental
BP
40127
Outcome_Other
BP
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Outcome_Physical
BP control