13528
document
A comparative study of a new food supplement , ViviScal , with fish extract for the treatment of hereditary androgenic alopecia in young males . A controlled , randomized , double-blind , parallel-group study compared the effects of ViviScal ( a new food supplement incorporating special marine extracts and a silica compound ) with those of a fish extract in the treatment of young males with hereditary androgenic alopecia . The pretreatment histological diagnosis was alopecia with a mild to moderate perifollicular inflammation zone . The study consisted of 20 subjects who received two tablets of ViviScal once daily and 20 who received two tablets of fish extract once daily for 6 months . The mean patient age and mean duration and severity of baldness compared well between the two groups . Most patients had been treated with long-term topical 2 % minoxidil for 1 year or more prior to the study . At baseline and after 6 months ' treatment , a biopsy was taken for histological examination . A non-vellus hair count was performed at baseline and after 2 , 4 and 6 months . In the fish extract treatment group three patients withdrew from the study before the fourth month due to lack of therapeutic effect . After 6 months ' treatment , patients receiving ViviScal showed a mean increase in non-vellus hair of 38 % compared with a 2 % increase in the fish extract treatment group ( P < 0.0001 ) . In the ViviScal group , 19 ( 95 % ) subjects showed both clinical and histological cure , whereas none treated with fish extract showed any clinical or histological difference after 6 months ' treatment ( P < 0.0001 ) . In both groups , a minimal decrease in the erythemal index was observed . In conclusion , ViviScal appears to be the first highly active treatment for androgenic alopecia in young males .
13529
Intervention_Pharmacological
ViviScal , with fish extract
13530
Intervention_Pharmacological
ViviScal ( a new food supplement incorporating special marine extracts and a silica compound )
13531
Intervention_Surgical
fish extract
13532
Intervention_Pharmacological
two tablets of ViviScal once daily
13533
Intervention_Control
two tablets of fish extract once daily
13534
Intervention_Pharmacological
minoxidil
13535
Intervention_Pharmacological
fish extract
13536
Intervention_Pharmacological
ViviScal
13537
Intervention_Pharmacological
fish extract
13538
Intervention_Pharmacological
ViviScal
13539
Intervention_Pharmacological
ViviScal
13540
Outcome_Physical
non-vellus hair count
13541
Outcome_Physical
lack of therapeutic effect
13542
Outcome_Physical
mean increase in non-vellus hair
13543
Outcome_Physical
both clinical and histological cure
13544
Outcome_Other
erythemal index
13545
Participant_Condition
hereditary androgenic alopecia
13546
Participant_Age
young
13547
Participant_Sex
males
13548
Participant_Age
young
13549
Participant_Sex
males
13550
Participant_Condition
androgenic alopecia
13551
Participant_Condition
alopecia
13552
Participant_Sample-size
20
13553
Participant_Sample-size
20
13554
Participant_Sample-size
three