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document
An analysis of the radiation related morbidity observed in a randomized trial of neutron therapy for bladder cancer . This report is an analysis of the morbidity in the bladder and bowel observed in a randomized trial of d ( 15 ) +Be neutrons versus megavoltage photons in the treatment of bladder cancer . Acute reactions in the bladder and bowel were significantly worse after photon therapy . Of the patients treated with photons 45.7 % had severe reactions in the bladder compared with 10.6 % after neutron therapy ( p less than 0.001 ) . Severe acute bowel reactions were observed in 8.5 % of the patients after photon therapy compared with 3.8 % after neutron therapy ( p less than 0.05 ) . Late reactions were significantly worse after neutrons . Severe late reactions in the bladder were seen in 58.5 % of patients after neutron therapy and in 40.5 % after photon therapy ( p less than 0.05 ) . In the bowel they were observed in 53.3 % of patients after neutron therapy compared with 8 % after photon therapy ( p less than 0.0001 ) . The disparity in the degree of early and late complications makes assessment of RBE values difficult . It is estimated that for bladder morbidity the RBE value , for photon dose fractions of 2.75 Gy , is less than 3.3 for early reactions and equal to 3.4 for late effects . The respective RBE values for early and late effects in the bowel are less than 3.4 and 3.8 .
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Intervention_Physical
neutron therapy
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Intervention_Physical
d ( 15 ) +Be neutrons
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Intervention_Physical
megavoltage photons
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Intervention_Physical
photon therapy
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Intervention_Physical
photons
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Intervention_Physical
neutron therapy
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Intervention_Physical
photon therapy
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Intervention_Physical
neutron therapy
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Intervention_Physical
neutrons
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Intervention_Physical
neutron therapy
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Intervention_Physical
photon therapy
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Intervention_Physical
neutron therapy
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Intervention_Physical
photon therapy
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Outcome_Other
morbidity
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Outcome_Mental
morbidity
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Outcome_Mental
Acute reactions
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Outcome_Physical
reactions in the bladder
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Outcome_Physical
Severe acute bowel reactions
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Outcome_Physical
Late reactions
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Outcome_Physical
Severe late reactions in the bladder
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Outcome_Physical
disparity in the degree of early and late complications
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Outcome_Physical
RBE values
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Outcome_Physical
bladder morbidity
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Outcome_Physical
RBE value
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Outcome_Physical
RBE values
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Participant_Condition
bladder cancer .
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Participant_Condition
morbidity in the bladder