39377
document
Using a novel wound model to investigate the healing properties of products for superficial wounds . OBJECTIVE To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds . METHOD Ten healthy volunteers were enrolled into an open-label , randomised , intra-individual comparison pilot study . Five standardised , superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed . Three products that promote a moist wound environment ( polyurethane , hydrocolloid , hydrogel ) and two standard plasters were randomly allocated to the test areas . RESULTS Evaluation of wound healing on days 2 , 5 , 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters . Visible re-epithelialisation was recorded on days 5 and 8 . More than 50 % of the wound area had closed . Video microscope images support these findings . The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2 . Best results were obtained for the polyurethane and hydrocolloid products , which had high mean scores close to the maximum of 10 . Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact , making the model highly suitable for the study of superficial wounds . CONCLUSION Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds . In general , products that promote a moist wound environment produced better results than those that promote a dry wound environment , with an earlier onset of healing and better healing outcomes . Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes . DECLARATION OF INTEREST This study was funded by Beiersdorf AG . Neither author has any interest in the sponsor 's commercial activities .
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Intervention_Pharmacological
polyurethane
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Intervention_Pharmacological
hydrocolloid
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Intervention_Pharmacological
hydrogel
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Intervention_Physical
two standard plasters
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Intervention_Pharmacological
polyurethane
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Intervention_Pharmacological
hydrocolloid
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Intervention_Pharmacological
polyurethane
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Intervention_Pharmacological
hydrocolloid
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Outcome_Physical
healing properties
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Outcome_Physical
healing properties
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Outcome_Physical
Evaluation of wound healing
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Outcome_Physical
Visible re-epithelialisation
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Outcome_Physical
wound area had closed
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Outcome_Physical
cosmetic outcomes
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Outcome_Physical
Histological examination of biopsies
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Outcome_Physical
dermis remained intact
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Outcome_Physical
performance of plasters
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Outcome_Physical
healing
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Outcome_Physical
healing outcomes
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Outcome_Physical
re-epithelialisation and overall cosmetic outcomes
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Participant_Sample-size
Ten
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Participant_Condition
superficial wounds .