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document
The effect of polyvinylpyrrolidone-iodine as an disinfectant in eye surgery . 105 patients admitted for cataract surgery were treated pre-operatively with polyvinylpyrrolidone-iodine ( PVP-I ) as a disinfectant , and consecutive bacterial cultures were obtained before initiating surgery and at the end of the operation . A control group ( n = 99 ) only had a standard disinfection procedure of the eye ( including instillation of Terramycin cum polymyxin B cream in the conjunctival sac the evening before surgery ) . The cultures obtained from the conjunctival sac of the control group principally showed growth of Staph . albus and Staph . aureus , and to a minor degree diphtheroids ( Corynebacterium species ) . Proteus mirabilis , Escherichia coli and micrococci . There was a significant quantitative diminished growth ( P less than 0.05 ) of bacteria in the group of patients treated with PVP-I compared to the control group . Concerning the growth of Staph . albus , this was reduced to almost one third and other bacteria were almost eliminated in the group receiving PVP-I . As we disclosed no toxic or allergic reaction post-operatively which could be related to the use of PVP-I as a disinfectant , this agent seems to constitute an effective pre-operative antimicrobial treatment , taking into consideration the broad antimicrobial spectrum of PVP-I shown by other authors .
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Intervention_Pharmacological
polyvinylpyrrolidone-iodine
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Intervention_Pharmacological
polyvinylpyrrolidone-iodine ( PVP-I )
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Intervention_Control
standard disinfection procedure
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Intervention_Pharmacological
Terramycin cum polymyxin B cream
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Intervention_Pharmacological
PVP-I
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Intervention_Pharmacological
PVP-I
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Intervention_Pharmacological
PVP-I
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Intervention_Pharmacological
PVP-I
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Outcome_Physical
disinfectant
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Outcome_Physical
standard disinfection
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Outcome_Other
significant quantitative diminished growth
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Outcome_Adverse-effects
toxic or allergic reaction post-operatively
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Outcome_Other
effective
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Participant_Sample-size
105
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Participant_Condition
cataract
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Participant_Sample-size
99