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document
A randomized trial of genetic and environmental risk assessment ( GERA ) for colorectal cancer risk in primary care : trial design and baseline findings . PURPOSE This paper describes an ongoing randomized controlled trial designed to assess the impact of genetic and environmental risk assessment ( GERA ) on colorectal cancer ( CRC ) screening . METHODS The trial includes asymptomatic patients who are 50-79years and are not up-to-date with CRC screening guidelines . Patients who responded to a baseline telephone survey are randomized to a GERA or Control group . GERA group participants meet with a nurse , decide whether to have a GERA blood test ( a combination of genetic polymorphism and folate ) , and , if tested , receive GERA feedback . Follow-up telephone surveys are conducted at 1 and 6months . A chart audit is performed at 6months . RESULTS Of 2,223 eligible patients , 562 ( 25 % ) have enrolled . Patients who enrolled in the study were significantly younger than those who did not ( p < 0.001 ) . Participants tended to be 50-59years ( 64 % ) , female ( 58 % ) , white ( 52 % ) , married ( 51 % ) , and have more than a high school education ( 67 % ) . At baseline , most participants had some knowledge of CRC screening and GERA , viewed CRC screening favorably , and reported that they had decided to do screening . Almost half had worries and concerns about CRC . CONCLUSIONS One in four eligible primary care patients enrolled in the study . Age was negatively associated with enrollment . Prospective analyses using data for all participants will provide more definitive information on GERA uptake and the impact of GERA feedback .
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Intervention_Educational
genetic and environmental risk assessment ( GERA )
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Intervention_Educational
genetic and environmental risk assessment ( GERA )
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Intervention_Educational
GERA or
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Intervention_Control
Control group
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Intervention_Physical
blood test
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Intervention_Pharmacological
polymorphism
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Intervention_Pharmacological
folate
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Intervention_Other
Follow-up telephone surveys are conducted at 1 and 6months
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Intervention_Physical
GERA
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Outcome_Other
impact
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Outcome_Other
telephone survey
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Outcome_Other
telephone surveys
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Outcome_Other
chart audit
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Outcome_Other
knowledge of CRC screening
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Outcome_Other
worries and concerns
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Participant_Condition
colorectal cancer ( CRC )
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Participant_Condition
asymptomatic patients
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Participant_Age
50-79years
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Participant_Condition
are not up-to-date with CRC screening guidelines
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Participant_Condition
GERA or Control group
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Participant_Sample-size
2,223
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Participant_Sample-size
562
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Participant_Condition
Patients who enrolled in the study were significantly younger than those who did not ( p < 0.001 )
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Participant_Sex
female
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Participant_Sample-size
( 58 % )