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document
Effect of systemic penicillin on pain in untreated irreversible pulpitis . OBJECTIVE The purpose of this prospective , randomized , double-blind study was to determine the effect of penicillin on pain in untreated teeth diagnosed with irreversible pulpitis . STUDY DESIGN Forty emergency patients participated , and each had a clinical diagnosis of an irreversible pulpitis . Patients randomly received a 7-day oral dose ( 28 capsules , 500 mg each , to be taken every 6 hours ) of either penicillin or a placebo control in a double-blind manner . No endodontic treatment was performed . Each patient also received ibuprofen ; acetaminophen with codeine ( 30 mg ) ; and a 7-day diary to record pain , percussion pain , and number and type of pain medication taken . RESULTS The administration of penicillin did not significantly ( P > .05 ) reduce pain , percussion pain , or the number of analgesic medications taken by patients with untreated irreversible pulpitis . The majority of patients with untreated irreversible pulpitis had significant pain and required analgesics to manage this pain . CONCLUSION Penicillin should not be prescribed for untreated irreversible pulpitis because penicillin is ineffective for pain relief .
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Intervention_Pharmacological
systemic penicillin
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Intervention_Pharmacological
penicillin
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Intervention_Pharmacological
penicillin
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Intervention_Control
placebo
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Intervention_Pharmacological
ibuprofen
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Intervention_Pharmacological
acetaminophen with codeine
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Intervention_Educational
diary to record pain
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Intervention_Pharmacological
penicillin
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Outcome_Mental
7-day diary to record pain
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Outcome_Mental
percussion pain
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Outcome_Mental
number and type of pain medication
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Outcome_Pain
pain
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Outcome_Pain
percussion pain
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Outcome_Other
number of analgesic medications
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Outcome_Pain
significant pain
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Participant_Condition
pulpitis
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Participant_Sample-size
Forty