92541
document
The influence of sequential annual vaccination and of DHEA administration on the efficacy of the immune response to influenza vaccine in the elderly . The present study examined the effect of repeated vaccination and of dehydroepiandrosterone ( DHEA ) treatment on the immune response to influenza vaccine in elderly subjects . Seventy-one elderly volunteers , aged 61-89 years , enrolled in a prospective randomized , double-blind study to receive either DHEA ( 50 mg qd p.o . for 4 consecutive days starting 2 days before immunization ) or placebo . Antibody response against the three strains of vaccine was measured before and 28 days after vaccination , and compared between previously vaccinated and non-vaccinated subjects . DHEA treatment did not enhance established immunity . A significant decrease in attainment of protective antibody titer ( titer of 1:40 or greater ) against A/Texas in subjects with non-protective baseline antibody titer was recorded following DHEA treatment compared to placebo ( 52 vs. 84 % , P < 0.05 ) . Post-immunization titers against influenza A strains were significantly higher in those subjects who were never immunized before . Additionally , post-vaccination protective titers against the A/Johannesburg strain were more prevalent in those subjects who were never vaccinated before . The results were not the same for anti-B/Harbin antibodies-repeated vaccination caused a non-significant increase in HI titer in previously vaccinated subjects .
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Intervention_Pharmacological
vaccination
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Intervention_Pharmacological
DHEA administration
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Intervention_Pharmacological
vaccination
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Intervention_Pharmacological
dehydroepiandrosterone ( DHEA )
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Intervention_Pharmacological
influenza vaccine
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Intervention_Pharmacological
DHEA
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Intervention_Control
placebo .
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Intervention_Pharmacological
DHEA treatment
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Intervention_Pharmacological
DHEA treatment
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Outcome_Physical
established immunity .
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Outcome_Other
protective antibody titer
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Outcome_Other
Post-immunization titers
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Outcome_Other
post-vaccination protective titers
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Participant_Condition
influenza vaccine
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Participant_Age
elderly
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Participant_Age
elderly
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Participant_Sample-size
Seventy-one
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Participant_Age
elderly
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Participant_Age
61-89 years