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document
Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids : the DiOGenes study . Blood lipid response to a given dietary intervention could be determined by the effect of diet , gene variants or gene-diet interactions . The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet , among overweight European adults participating in the Diet Obesity and Genes study . By multiple linear regressions , 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol , LDL-cholesterol , HDL-cholesterol and TAG after an 8-week low-energy diet ( only main effect ) , and a 6-month ad libitum weight maintenance diet , with different contents of dietary protein or glycaemic index . After adjusting for multiple testing , a SNP-dietary protein interaction effect on TAG was identified for lipin 1 ( LPIN1 ) rs4315495 , with a decrease in TAG of 20.26 mmol/l per A-allele/protein unit ( 95 % CI 20.38 , 20.14 , P=0.000043 ) . In conclusion , we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes , selected for their involvement in lipid metabolism pathways , and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration .
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Intervention_Physical
given dietary intervention
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Intervention_Pharmacological
given diet
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Intervention_Physical
8-week low-energy diet
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Intervention_Pharmacological
6-month ad libitum weight maintenance diet
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Intervention_Pharmacological
dietary protein
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Intervention_Physical
glycaemic index
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Intervention_Pharmacological
SNP-diet interactions
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Outcome_Physical
blood lipids
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Outcome_Physical
Blood lipid
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Outcome_Physical
nutrient-sensitive genes involved in lipid metabolism
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Outcome_Physical
lipid profile
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Outcome_Physical
total cholesterol , LDL-cholesterol , HDL-cholesterol and TAG
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Outcome_Physical
SNP-dietary protein interaction effect on TAG
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Outcome_Physical
decrease in TAG
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Outcome_Physical
SNP-diet interactions for blood lipid profiles
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Participant_Condition
DiOGenes study .
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Participant_Condition
overweight
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Participant_Condition
Diet Obesity and Genes study
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Participant_Sample-size
twenty-four candidate genes were investigated