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document
Application of ambulatory blood pressure monitoring to clinical therapeutic decisions in hypertension . The antihypertensive efficacies of lisinopril and captopril were compared using office sphygmomanometry and 24-h ambulatory blood pressure monitoring . In a double-blind , prospective , randomly allocated trial , the patients were given increasing doses of captopril at 25-100 mg twice a day or lisinopril at 10-40 mg once a day until a clinical response was achieved or the highest dose was reached . A response was defined as a reduction in diastolic pressure below 90 mmHg or a fall of at least 10 mmHg from baseline . The ambulatory monitoring showed that lisinopril reduced blood pressure from baseline to the final value and maintained the reduction to a greater degree than captopril throughout 24-h periods of observation . The office measurements showed a similar trend , but the intertreatment differences did not reach statistical significance . No first-dose side effects were observed with either drug . Once a day lisinopril appeared to be a more effective antihypertensive regimen than twice a day captopril .
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Intervention_Pharmacological
lisinopril
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
lisinopril
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
lisinopril
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Intervention_Pharmacological
antihypertensive regimen
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Outcome_Other
antihypertensive
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Outcome_Physical
clinical response
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Outcome_Physical
reduction in diastolic pressure below 90 mmHg or a fall of at least 10 mmHg from baseline .
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Outcome_Physical
blood pressure
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Outcome_Physical
maintained the reduction
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Outcome_Physical
office measurements
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Participant_Condition
hypertension .
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Participant_Condition
the patients