81900
document
A comparison of 1- and 3-minute lockout periods during patient-controlled sedation with midazolam . PURPOSE The maximum effect of midazolam injected intravenously occurs in about 3 minutes . Patient-controlled sedation carried out with 1-mg increments of midazolam at 3-minute intervals provides comparable conditions to that of doctor-controlled sedation carried out with 1-mg increments at 1-minute intervals , except for the longer duration taken for the patients to achieve satisfactory sedation prior to surgery . The purpose of this study was to find out how safe it would be to shorten the interval of increments of midazolam to 1 minute in patient-controlled sedation . PATIENTS AND METHODS In a randomized crossover study , 26 patients undergoing bilateral lower third molar surgery at two visits had patient-controlled sedation with 1 mg midazolam increments at 1-minute or 3-minute intervals at one visit and the alternative at the other visit . RESULTS The time taken for patients to achieve a degree of sedation that they thought was sufficient to tolerate the surgery was significantly longer when the increment interval was 3 minutes ( t = -4.8 ; P < .05 ) . Both techniques provided good operating conditions , stable vital signs , mild to moderate sedation , without loss of verbal contact . CONCLUSION A significant majority preferred the sedation technique with 1-minute increment intervals ( chi 2 = 4.6 ; P < .05 ) .
81901
Intervention_Pharmacological
midazolam .
81902
Intervention_Pharmacological
midazolam
81903
Intervention_Pharmacological
midazolam
81904
Intervention_Pharmacological
midazolam
81905
Intervention_Pharmacological
patient-controlled sedation
81906
Intervention_Pharmacological
midazolam
81907
Outcome_Physical
degree of sedation
81908
Outcome_Other
operating conditions
81909
Outcome_Physical
vital signs
81910
Outcome_Other
loss of verbal contact .
81911
Participant_Condition
patient-controlled sedation with midazolam .
81912
Participant_Sample-size
26
81913
Participant_Condition
bilateral lower third molar surgery