66260
document
Intravenous flecainide versus verapamil for acute conversion of paroxysmal atrial fibrillation or flutter to sinus rhythm . In a single-blind randomized study , the efficacy of intravenous flecainide ( 2 mg/kg/10 minutes ) versus verapamil ( 10 mg/1 minute ) was assessed in 40 patients with paroxysmal atrial fibrillation ( AF ) or atrial flutter ( AFI ) . The treatment was considered successful if sinus rhythm occurred within 1 hour . Of 20 patients receiving flecainide , 14 of 17 ( 82 % ) with AF converted to sinus rhythm , but in 3 patients with AFI flecainide failed . All patients treated with verapamil ( 17 AF , 3 AFI ) showed lower ventricular rates after 1 hour ; however , only 1 ( 6 % ) with AF converted to sinus rhythm and 1 ( 6 % ) converted to AFI . Patients who did not convert to sinus rhythm after treatment with verapamil were treated with flecainide and observed for another hour . After the change to flecainide , 9 of 15 patients ( 60 % ) with AF still converted . Thus , 23 of 32 patients ( 72 % ) with AF and none of 7 with AFI converted to sinus rhythm after treatment with flecainide . Conversion to sinus rhythm was achieved in 19 of 22 patients ( 86 % ) when AF lasted less than 24 hours and in 4 of 10 ( 40 % ) when the arrhythmia lasted greater than 24 hours . Transient adverse effects were noted in 10 patients ( 26 % ) after flecainide . In summary , flecainide is an effective and safe drug for conversion of paroxysmal AF to sinus rhythm , but ineffective for AFI . Verapamil appears to be of no use for conversion of AF or AFI to sinus rhythm .
66261
Intervention_Pharmacological
Intravenous flecainide
66262
Intervention_Pharmacological
verapamil
66263
Intervention_Pharmacological
intravenous flecainide
66264
Intervention_Pharmacological
verapamil
66265
Intervention_Pharmacological
flecainide
66266
Intervention_Pharmacological
flecainide
66267
Intervention_Pharmacological
verapamil
66268
Intervention_Pharmacological
verapamil
66269
Intervention_Pharmacological
flecainide
66270
Intervention_Pharmacological
flecainide
66271
Intervention_Pharmacological
Verapamil
66272
Outcome_Other
efficacy
66273
Outcome_Physical
sinus rhythm
66274
Outcome_Physical
lower ventricular rates
66275
Outcome_Physical
converted .
66276
Outcome_Physical
Conversion to sinus rhythm
66277
Outcome_Adverse-effects
Transient adverse effects
66278
Outcome_Other
effective and safe drug
66279
Outcome_Physical
conversion of AF or AFI
66280
Participant_Condition
sinus rhythm
66281
Participant_Sample-size
40
66282
Participant_Condition
paroxysmal atrial fibrillation
66283
Participant_Sample-size
20
66284
Participant_Sample-size
14
66285
Participant_Sample-size
17
66286
Participant_Condition
sinus rhythm