34452
document
Evaluation of the effects of human leukocyte IFN-alpha on the immune response to the HBV vaccine in healthy unvaccinated individuals . HBV vaccine needs 3 injections over 6 months to induce immunity . Thus , the use of adjuvants capable of inducing earlier immune protection would be highly desirable . Most adjuvants may act by inducing cytokines , and among them , type I interferons ( IFNs ) , deserve a special attention in view of the potent immunomostimulatory activity observed in mouse models and on dendritic cell functions . The aim of the present trial was to evaluate the effects of IFN-alpha administered as an adjuvant of HBV vaccine in healthy unvaccinated individuals . No significant enhancing effect on the antibody response was observed , in spite of an early and transient upregulation of costimulatory molecule expression on peripheral blood mononuclear cells , which may be suggestive of an IFN-mediated activation of antigen presenting cells . We conclude that , under the conditions used in this trial , natural IFN-alpha does not act as an adjuvant of the HBV vaccine in healthy unvaccinated individuals .
34453
Intervention_Pharmacological
leukocyte IFN-alpha
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Intervention_Pharmacological
HBV vaccine
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Intervention_Pharmacological
HBV vaccine
34456
Intervention_Pharmacological
IFN-alpha
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Intervention_Pharmacological
adjuvant of HBV vaccine
34458
Intervention_Pharmacological
IFN-alpha
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Outcome_Physical
immune response to the HBV vaccine
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Outcome_Physical
antibody response
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Outcome_Physical
peripheral blood mononuclear cells
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Participant_Condition
healthy unvaccinated individuals .