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document
Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma . BACKGROUND/AIMS Vitamin K2 ( VK2 ) appears to have a potent inhibitory activity for cell growth including HCC cells . We investigated whether VK2 could reduce incidence of tumor recurrence after treatment of HCC . Forty-five patients with cured or possibly cured HCC were randomly selected , assigning patients to treatment ( n=21 ) or control group ( n=24 ) with randomization list . METHODOLOGY For the treatment group , forty-five mg of Glakay was given orally every day after therapy for HCC . No patients complained of adverse effects . Abdominal ultrasonography and dynamic CT were performed at 3-month intervals . Recurrence was confirmed by abdominal angiography . RESULTS Recurrence of HCC occurred in 7 cases ( 33.3 % ) for the treatment group and 12 cases ( 50.0 % ) for the control group during mean observation periods of 19.5 and 16.5 months , respectively . Administration of VK2 was not an independent variable for the recurrence on univariate analysis . Cumulative incidence of HCC recurrence did not differ between the two groups , and the cumulative survival rate tended to be high in treatment group ( p =0.054 ) . Cox regression analysis revealed that serum albumin concentration alone was an independent factor affecting the recurrence . CONCLUSIONS These findings suggest that VK2 does not appear to prevent recurrence of HCC after curative treatment . Our study is preliminary and large-scale trials are needed to determine whether VK2 is of benefit to decrease the recurrence of HCC .
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Intervention_Pharmacological
vitamin K2
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Intervention_Pharmacological
Vitamin K2 ( VK2 )
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Intervention_Pharmacological
VK2
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Intervention_Control
control
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Intervention_Pharmacological
Glakay
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Intervention_Physical
dynamic CT
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Intervention_Physical
abdominal angiography
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Outcome_Other
recurrence
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Outcome_Adverse-effects
adverse effects
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Outcome_Physical
Recurrence
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Outcome_Physical
Recurrence of HCC
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Outcome_Physical
recurrence
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Outcome_Other
Cumulative incidence of HCC recurrence
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Outcome_Mortality
cumulative survival rate
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Outcome_Physical
serum albumin concentration
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Outcome_Physical
recurrence of HCC
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Outcome_Physical
recurrence of HCC
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Participant_Condition
hepatocellular carcinoma
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Participant_Sample-size
Forty-five patients
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Participant_Condition
HCC