79115
document
Blood pressure control during weight reduction in obese hypertensive men : separate effects of sodium and energy restriction . The separate and combined effects of dietary energy and sodium restriction on regulation of blood pressure were investigated in 30 middle aged obese men with essential hypertension attending the outpatient department . In group 1 ( n = 15 ) a basal period with no dietary restriction was followed by a period taking an energy reduced diet ( 5.1 MJ ; 1230 kcal ) , the sodium intake being supplemented and hence unchanged ( 1 : ErSn ) . In group 2 ( n = 15 ) the basal period preceded a control period with no intervention , which was followed by taking a diet restricted in energy ( 5.1 MJ ; 1220 kcal ) and sodium ( 2 : ErSr ) . During period 1 : ErSn there were reductions in heart rate and urinary noradrenaline output but not in systolic or diastolic blood pressure . Body weight decreased by 4.9-11.7 kg and urinary sodium excretion did not change . In period 2 : ErSr urinary sodium output was reduced by 81.4 ( SEM 17.8 ) mmol ( mEq ) /24 h and there was a weight loss of 8.2 ( SEM 0.7 ) kg . Systolic and diastolic blood pressures fell significantly , as did the heart rate and urinary noradrenaline excretion . These results show that in hypertensive obese men a moderate weight reducing diet decreases indices of sympathetic nervous system activity . Reduction of blood pressure to the normotensive range was observed only when there was a concomitant restriction of sodium intake .
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Intervention_Pharmacological
sodium restriction
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Intervention_Control
no dietary restriction
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Intervention_Pharmacological
sodium intake being supplemented
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Intervention_Control
no intervention
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Intervention_Pharmacological
sodium
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
urinary noradrenaline output
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Outcome_Physical
systolic or diastolic blood pressure
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Outcome_Physical
Body weight
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Outcome_Physical
urinary sodium excretion
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Outcome_Physical
urinary sodium output
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Outcome_Physical
weight loss
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Outcome_Physical
Systolic and diastolic blood pressures
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Outcome_Physical
heart rate
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Outcome_Physical
urinary noradrenaline excretion
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Outcome_Physical
sympathetic nervous system activity
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Outcome_Physical
blood pressure
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Participant_Condition
obese hypertensive
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Participant_Sex
men
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Participant_Sample-size
30
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Participant_Age
middle aged
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Participant_Condition
obese
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Participant_Condition
essential hypertension
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Participant_Condition
hypertensive obese
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Participant_Sex
men