42825
document
Effects of topical boswellic acid on photo and age-damaged skin : clinical , biophysical , and echographic evaluations in a double-blind , randomized , split-face study . Boswellic acids ( BAs ) are pentacyclic triterpenes with strong anti-inflammatory activity ; their most important source is the extract of the gum resin of Boswellia serrata , a tropical tree that grows in India and Africa . In the present randomized , double-blind , split-face , comparative study we have assessed efficacy , tolerability , and safety of a base cream containing 0.5 % BAs as compared to the same cream without these active ingredients in the treatment of clinical manifestations of photoaging of facial skin . Fifteen female volunteers were enrolled ; they applied creams once daily for 30 days . At baseline , at the end of the treatment , and after a 2-month follow-up , clinical findings were assessed according to the Dover classification scale for photoaging and by biophysical and ecographic measurements . We registered a significant improvement of tactile roughness and fine lines in the half side of the face treated with BAs ; noninvasive instrumental diagnostic investigations showed an improvement of elasticity , a decrease of sebum excretion , and a change of echographic parameters suggesting a reshaping of dermal tissue . The treatment was always well tolerated without adverse effects . The present findings seem to indicate that the topical application of BAs may represent a suitable treatment option for selected features of skin photoaging .
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Intervention_Pharmacological
topical boswellic acid
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Intervention_Pharmacological
Boswellic acids ( BAs )
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Intervention_Pharmacological
base cream containing 0.5 % BAs
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Intervention_Pharmacological
the same cream without these active ingredients
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Intervention_Pharmacological
BAs
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Intervention_Pharmacological
BAs
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Outcome_Physical
clinical
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Outcome_Physical
biophysical
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Outcome_Physical
echographic evaluations
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Outcome_Other
efficacy , tolerability , and safety
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Outcome_Other
Dover classification scale for photoaging
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Outcome_Other
biophysical and ecographic measurements
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Outcome_Other
tactile roughness and fine lines
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Outcome_Other
elasticity
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Outcome_Other
sebum excretion
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Outcome_Other
reshaping of dermal tissue
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Outcome_Other
tolerated
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Outcome_Adverse-effects
adverse effects