89652
document
A limited sampling method for the estimation of flunarizine area under the curve ( AUC ) and maximum plasma concentration ( Cmax ) . A limited sampling model has been developed for flunarizine following a 30 mg oral dose in epileptic patients who were receiving phenytoin or carbamazepine or both , to estimate the area under the curve ( AUC ) and maximum plasma concentration ( Cmax ) . The model was developed using training data sets from 30 , 20 , 15 , or 10 patients at one or two time points . The equations describing the models for AUC using two time points ( 3 and 24h ) and Cmax for the training data set of 30 subjects were AUCpredicted = 11.1 C3h + 121.4 C24h - 157 ( r = 0.80 ) Cmax ( predicted ) = 0.036 AUC + 42.9 ( r = 0.74 ) The model was validated on 64 patients who received flunarizine orally . The model provided reasonably good estimates for both AUC and Cmax . The mean predicted AUC of flunarizine was 1230 +/- 717 ng h mL-1 , whereas the observed AUC was 1203 +/- 900 ng h mL-1 . The bias of the prediction was 2 % and precision was 28 % . The mean predicted Cmax of flunarizine was 86 +/- 32 ng mL-1 as compared to an observed mean Cmax of 90 +/- 42 ng mL-1 . The bias and precision of the prediction were 4 % and 24 % , respectively . The method described here may be used to estimate AUC and Cmax for flunarizine without detailed pharmacokinetic studies .
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Intervention_Pharmacological
phenytoin
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Intervention_Pharmacological
carbamazepine
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Intervention_Physical
maximum plasma concentration ( Cmax )
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Outcome_Physical
estimation of flunarizine area under the curve ( AUC ) and maximum plasma concentration ( Cmax ) .
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Outcome_Physical
estimate the area under the curve ( AUC ) and maximum plasma concentration ( Cmax ) .
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Outcome_Physical
estimates for both AUC
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Outcome_Physical
Cmax
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Outcome_Physical
mean predicted AUC of flunarizine
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Outcome_Physical
observed AUC
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Outcome_Other
bias of the prediction
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Outcome_Physical
predicted Cmax of flunarizine
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Outcome_Physical
observed mean Cmax
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Outcome_Other
bias and precision of the prediction
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Participant_Condition
epileptic patients
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Participant_Condition
receiving phenytoin or carbamazepine or both
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Participant_Sample-size
64