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document
Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children : a randomized controlled trial . An open-label , randomized controlled study was conducted at a tertiary care teaching hospital to compare efficacy and safety of intravenous sodium valproate versus diazepam infusion for control of refractory status epilepticus . Forty children with refractory status epilepticus were randomized to receive either intravenous sodium valproate or diazepam infusion . Refractory status epilepticus was controlled in 80 % of the valproate and 85 % of the diazepam patients . The median time to control refractory status epilepticus was less in the valproate group ( 5 minutes ) than the diazepam group ( 17 minutes ; P < .001 ) . None of the patients in the valproate group required ventilation or developed hypotension , whereas in the diazepam group 60 % required ventilation and 50 % developed hypotension after starting diazepam infusion . No adverse effects on liver functions were seen with valproate . It is concluded that intravenous sodium valproate is an effective alternative to diazepam infusion in controlling refractory status epilepticus in children and is free of respiratory depression and hypotension .
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Intervention_Pharmacological
Intravenous sodium valproate
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Intervention_Pharmacological
diazepam infusion
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Intervention_Pharmacological
intravenous sodium valproate
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Intervention_Pharmacological
diazepam infusion
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Intervention_Pharmacological
intravenous sodium valproate or diazepam infusion
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Outcome_Physical
Refractory status epilepticus
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Outcome_Other
median time to control refractory status epilepticus
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Outcome_Physical
ventilation or developed hypotension
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Outcome_Physical
ventilation
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Outcome_Physical
hypotension
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Outcome_Adverse-effects
adverse effects on liver functions
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Participant_Condition
refractory status epilepticus
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Participant_Age
children
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Participant_Sample-size
Forty
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Participant_Condition
refractory status epilepticus
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Participant_Age
children