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document
Capsaicin jelly against migraine pain . OBJECTIVE Recent studies support the role of extracranial perivascular afferents in a substantial percentage of migraineurs . Perivascular afferent fibres of the superficial temporal artery contain peptides , like calcitonin gene-related peptide ( CGRP ) and substance P ( SP ) . CGRP and SP are considered relevant in the genesis of migraine pain . Capsaicin is an agonist of the transient receptor potential vanilloid type 1 . It causes membrane depolarisation of sensory neurons , which release CGRP , SP and other pain peptides ; excitation is followed by a refractory state , causing inactivation . Topical capsaicin has been found to be efficacious in several types of neuropathic pain . We attempted to verify whether topical periarterial capsaicin could ameliorate pain in absence of and during a migraine attack . METHODS On 23 migraineurs showing pain at pressure on scalp arteries , we administered topical capsaicin 0.1 % or vaseline jelly on painful arteries in absence of migraine attack . In those having pain reduction > 50 % , we made the same comparison during a migraine attack . RESULTS Topical capsaicin caused > 50 % reduction of arterial pain in absence of attack in 17/23 patients , as opposed to two with vaseline . During attacks of mild- to moderate-intensity , > 50 % improvement was obtained in 11/17 with capsaicin and in one with vaseline . CONCLUSIONS Although referring to a small number of patients , our data show that topical capsaicin may relieve arterial pain in absence of and during a migraine attack in a substantial number of patients experiencing scalp arterial tenderness . More active capsacinoids might be tried in the future and could provide a new method for treating migraine attacks .
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Intervention_Pharmacological
Capsaicin jelly
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Intervention_Pharmacological
Capsaicin
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Intervention_Pharmacological
Topical capsaicin
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Intervention_Pharmacological
topical periarterial capsaicin
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Intervention_Pharmacological
topical capsaicin 0.1 % or vaseline jelly
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Intervention_Pharmacological
Topical capsaicin
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Intervention_Pharmacological
capsaicin
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Intervention_Control
vaseline
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Intervention_Pharmacological
topical capsaicin
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Intervention_Pharmacological
capsacinoids
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Outcome_Pain
migraine pain
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Outcome_Pain
neuropathic pain
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Outcome_Pain
pain in absence of and during a migraine attack
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Outcome_Pain
arterial pain
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Outcome_Pain
arterial pain
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Participant_Condition
migraine pain .
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Participant_Sample-size
23