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document
Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men . BACKGROUND Krill is an increasingly popular source of marine n-3 ( ω-3 ) PUFA that is seen as a premium product . However , to our knowledge , the effect of krill-oil supplementation on insulin sensitivity in humans has not been reported . OBJECTIVE We assessed whether supplementation with a blend of krill and salmon ( KS ) oil [ which is rich in eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ) ] affects insulin sensitivity in overweight men . DESIGN The design was a randomized , double-blind , controlled crossover trial . A total of 47 men with a mean ± SD age of 46.5 ± 5.1 y , who were overweight [ body mass index ( in kg/m ( 2 ) ) from 25 to 30 ] but otherwise healthy , received 5 1-g capsules of KS oil or a control ( canola oil ) for 8 wk and crossed over to another treatment after an 8-wk washout period . The primary outcome was insulin sensitivity assessed by using the Matsuda method from an oral-glucose-tolerance test . Secondary outcomes included lipid profiles , inflammatory markers , 24-h ambulatory blood pressure , and carotid artery intimamedia thickness . RESULTS Unexpectedly , insulin sensitivity ( per the Matsuda index ) was 14 % lower with the KS oil than with the control oil ( P = 0.049 ) . A mediation analysis showed that , after controlling for the likely positive effects of blood EPA and DHA ( i.e. , the omega-3 index ) , the reduction in insulin sensitivity after KS-oil supplementation was more marked [ 27 % lower than with the control oil ( P = 0.009 ) ] . CONCLUSIONS Supplementation with a blend of KS oil is associated with decreased insulin sensitivity . Thus , krill-oil supplementation in overweight adults could exacerbate risk of diabetes and cardiovascular disease . This trial was prospectively registered at the Australian New Zealand Clinical Trials Registry as ACTRN12611000602921 .
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Intervention_Pharmacological
blend of krill and salmon oil
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Intervention_Pharmacological
Krill
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Intervention_Pharmacological
KS oil
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Intervention_Control
control
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Outcome_Physical
insulin sensitivity
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Outcome_Physical
lipid profiles , inflammatory markers , 24-h ambulatory blood pressure , and carotid artery intimamedia thickness
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Outcome_Physical
insulin sensitivity
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Outcome_Physical
insulin sensitivity
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Outcome_Physical
insulin sensitivity
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Participant_Condition
overweight
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Participant_Sex
men
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Participant_Age
in
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Participant_Condition
overweight
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Participant_Sex
men
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Participant_Sample-size
47 men
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Participant_Age
age of 46.5 ± 5.1 y ,
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Participant_Condition
overweight
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Participant_Condition
overweight
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Participant_Age
adults