84663
document
Analgesia after caesarean section with intramuscular ketorolac or pethidine . We compared , in a double-blind randomised study , intramuscular ketorolac 30 mg ( n = 49 ) and intramuscular pethidine 75 mg ( n = 51 ) for analgesia after elective caesarean section under general anaesthesia . Anaesthesia was induced with thiopentone and suxamethonium and maintained with atracurium , nitrous oxide and isoflurane . Intravenous fentanyl 100 micrograms was given after delivery of the neonate . In the recovery ward , patients who requested analgesia were allocated randomly to receive ketorolac 30 mg or pethidine 75 mg intramuscularly . Analgesia was assessed at intervals up to six hours , using a visual analogue scale and a four-point verbal scale , while duration of analgesia was taken as the time until the patient requested additional analgesia . There was no difference in the duration of analgesia between groups ( Mann-Whitney test P = 0.27 , Mantel-Haentszel test P = 0.17 ) . Twenty-six patients in the ketorolac group and 17 patients in the pethidine group requested further analgesia by 90 minutes . However , four patients in the ketorolac group and six patients in the pethidine group requested no further analgesia within 24 hours . Pain VAS and overall assessment of analgesia was similar between groups , although more side-effects ( nausea , dizziness ) were noted in the pethidine group . Ketorolac 30 mg and pethidine 75 mg provided similar but variable quality of analgesia after caesarean section .
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Intervention_Pharmacological
ketorolac
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Intervention_Pharmacological
pethidine
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Intervention_Pharmacological
intramuscular ketorolac
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Intervention_Pharmacological
intramuscular pethidine
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Intervention_Pharmacological
analgesia
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Intervention_Pharmacological
thiopentone
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Intervention_Pharmacological
suxamethonium
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Intervention_Pharmacological
atracurium
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Intervention_Pharmacological
nitrous oxide and isoflurane
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Intervention_Pharmacological
Intravenous fentanyl
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Intervention_Pharmacological
ketorolac
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Outcome_Physical
Analgesia
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Outcome_Physical
analgesia
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Outcome_Physical
Analgesia
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Outcome_Other
Mann-Whitney test
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Outcome_Other
Mantel-Haentszel
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Outcome_Physical
further analgesia
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Outcome_Physical
no further analgesia
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Outcome_Pain
Pain VAS
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Outcome_Physical
overall assessment of analgesia
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Outcome_Adverse-effects
nausea
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Outcome_Physical
dizziness