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document
Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction . BACKGROUND The effect of L-arginine and L-citrulline on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction ( HFpEF ) is unknown . We have therefore evaluated , in a randomized clinical trial , the effect of these aminoacids in chronic outstanding and stable patients with HFpEF . METHODS AND RESULTS All patients underwent an echocardiogram and radioisotopic ventriculography rest/exercise , and were randomized in a consecutive manner to the L-arginine group ( n = 15 ; 8 g/day ) ; and the citrulline malate group ( n = 15 ; 3 g/day ) . The duration of follow-up was two months . The principal echocardiographic finding was a statistically significant decrease in pulmonary artery pressure in the L-arginine ( 56.3 ± 10 vs 44 ± 16.5 mm Hg , p < 0.05 ) and the citrulline ( 56.67 ± 7.96 vs 47.67 ± 8.59 mm Hg , p < 0.05 ) groups . Duration on treadmill and right ventricular ejection fraction post exercise increased , while diastolic and systolic artery pressure decreased significantly in both groups . There were no other statistically significant differences between the groups . CONCLUSIONS Administration of L-arginine and citrulline to patients with HFpEF improved right ventricular function by increasing right ventricular ejection fraction , and probably decreasing systolic pulmonary artery pressure .
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Intervention_Pharmacological
L-arginine
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Intervention_Pharmacological
L-citrulline oral supplementation
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Intervention_Pharmacological
L-arginine
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Intervention_Pharmacological
L-citrulline
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Intervention_Physical
echocardiogram and radioisotopic ventriculography rest/exercise
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Intervention_Pharmacological
L-arginine group
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Intervention_Pharmacological
citrulline malate group
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Intervention_Pharmacological
L-arginine
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Outcome_Physical
blood pressure
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Outcome_Physical
right ventricular function
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Outcome_Physical
blood pressure
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Outcome_Physical
right ventricular function
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Outcome_Physical
pulmonary artery pressure
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Participant_Condition
heart failure
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Participant_Condition
preserved ejection fraction
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Participant_Condition
heart failure patients with preserved ejection fraction ( HFpEF
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Participant_Condition
HFpEF