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document
Lipoprotein ( a ) serum levels in post-menopausal women treated with oral estrogens administered at different times . The different effects on serum lipoprotein ( a ) [ Lp ( a ) ] levels by administering estrogens at different times of the day ( 8 a.m. and 8 p.m. ) were evaluated in twenty-four post-menopausal women . Patients were assigned to one of the two treatment groups by random sampling numbers . Patients of both groups received 0.625 mg conjugated equine estrogens daily per os for 21 days . Group A patients ( n : 9 ) received the pill at 8 a.m. , and group B patients ( n : 12 ) received the pill at 8 p.m . There were no statistically significant differences between the two treatment groups as regards the anthropometric characteristics , the basal values of the Lp ( a ) , the sex steroid and pituitary hormone levels . Administration of conjugated equine estrogens resulted in decreased levels of Lp ( a ) only in group B after treatment . The different Lp ( a ) behaviour in the two groups and in the presence of the same serum hormonal levels , seems to be dependent on the existence of a circadian rhythm of the hepatic responsiveness to estrogens , whose expression is higher during evening hours .
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Intervention_Pharmacological
oral estrogens
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Intervention_Pharmacological
estrogens
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Intervention_Pharmacological
conjugated equine estrogens
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Intervention_Pharmacological
conjugated equine estrogens
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Outcome_Other
effects
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Outcome_Physical
anthropometric characteristics , the basal values of the Lp ( a ) , the sex steroid and pituitary hormone levels .
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Outcome_Physical
levels of Lp ( a )
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Participant_Condition
post-menopausal women treated with oral estrogens administered at different times .
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Participant_Condition
twenty-four post-menopausal women .