39064
document
Effects of propranolol on bone metabolism in the rat . Propranolol , a nonspecific beta-blocker has many physiologic effects . Its effects on bone in vivo are unknown , although beta receptor sites have been found on osteoblasts . In this study , the hypothesis tested was that low doses of propranolol could alter bone properties and enhance orthotopic endochondral bone formation . In a group of nonsurgical rats , propranolol treatment increased femoral torsional strength on biomechanical testing . In the rat surgical model used , right femora were fixed to a polyethylene plate and then defects were created mid-diaphysis and subsequently filled with demineralized bone matrix . These rats ( defect rats ) were randomly divided into groups that were given propranolol or a saline carrier for 19 consecutive days . In the defect rats , increased trabecular femoral metaphyseal mineral apposition rates were observed in propranolol-treated groups . Densitometry and roentgenographic scoring of callus formation after 12 weeks in propranolol-treated rats revealed increased callus and bone union . The results of this study indicate that propranolol treatment can significantly affect bone properties .
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Intervention_Pharmacological
propranolol
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Intervention_Pharmacological
Propranolol
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Intervention_Pharmacological
propranolol
39068
Intervention_Pharmacological
propranolol
39069
Intervention_Pharmacological
propranolol
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Intervention_Pharmacological
saline
39071
Intervention_Pharmacological
propranolol
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Outcome_Physical
bone metabolism
39073
Outcome_Physical
bone
39074
Outcome_Physical
bone properties
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Outcome_Physical
orthotopic endochondral bone formation .
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Outcome_Physical
femoral torsional strength
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Outcome_Physical
trabecular femoral metaphyseal mineral apposition rates
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Outcome_Physical
callus and bone union .
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Outcome_Physical
bone properties
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Participant_Condition
rat
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Participant_Condition
nonsurgical rats
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Participant_Condition
rat surgical model