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document
[ Value of combining 64 multi-slice spiral computer tomography and serum amyloid A protein in surgical decision-making in rectal cancer ] . OBJECTIVE To determine the accuracy and clinical value of combining 64 multi-slice spiral computer tomography ( MSCT ) and serum amyloid A protein ( SAA ) in the preoperative staging of rectal cancer . METHODS Prospectively enrolled patients with rectal cancer from October 2007 to October 2008 . The patients were randomly assigned into two groups : MSCT and SAA combined group : both MSCT and SAA combinative assessment were performed for preoperative evaluation ; MSCT group : only MSCT was performed preoperatively for tumor staging . The accuracy of the preoperative T , N , M , and TNM staging and the concordance rate of predictive operative strategy were compared between the two groups . RESULTS Total of 225 cases with rectal cancer were enrolled in this study . There were 110 cases in MSCT and SAA combined group and 115 cases in MSCT group . The baseline characteristics was comparable between the two groups . For MSCT and SAA combined group , the accuracies of preoperative staging of T , N , M and TNM was 87.3 % , 85.2 % , 100 % and 86.4 % , respectively ; and for MSCT group , the corresponding rates was 85.2 % , 67.0 % , 100 % and 66.1 % , respectively . Statistical differences was found in the accuracy of preoperative N and TNM staging between the two groups ( P = 0.009 and 0.001 , respectively ) . In addition , there was statistical difference in the accuracy of prediction to operative procedures between the two groups ( 94.7 % vs. 81.7 % , P = 0.003 ) . CONCLUSION Combinative assessment of MSCT and SAA could improve the accuracy of preoperative staging , and thus provide higher predictive coincidence rate of operative procedures .
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Intervention_Other
64 multi-slice spiral
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Intervention_Physical
computer tomography
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Intervention_Pharmacological
serum amyloid A protein
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Intervention_Other
64 multi-slice spiral computer tomography ( MSCT
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Intervention_Pharmacological
serum amyloid A protein ( SAA )
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Intervention_Other
MSCT
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Intervention_Pharmacological
SAA
44304
Intervention_Physical
MSCT
44305
Intervention_Pharmacological
SAA
44306
Intervention_Physical
MSCT group
44307
Intervention_Physical
MSCT
44308
Intervention_Pharmacological
SAA
44309
Intervention_Physical
MSCT
44310
Intervention_Physical
MSCT
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Intervention_Pharmacological
SAA
44312
Intervention_Physical
MSCT
44313
Intervention_Pharmacological
SAA
44314
Outcome_Other
accuracies of preoperative staging of T , N , M and TNM
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Outcome_Other
accuracy of preoperative N and TNM staging
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Outcome_Other
accuracy of prediction to operative procedures
44317
Participant_Condition
rectal cancer
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Participant_Condition
rectal cancer
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Participant_Condition
rectal cancer
44320
Participant_Sample-size
225
44321
Participant_Condition
rectal cancer
44322
Participant_Sample-size
110
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Participant_Sample-size
115