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document
Enoxaparin in the prevention of deep venous thrombosis after major surgery : multicentric study . The Italian Study Group . DVT is a very frequent complication of general surgery . Heparin and , more recently , LMWHs can successfully prevent post surgical thromboembolism . One thousand one hundred and twenty-two patients ( 533 males and 589 females ; mean age 62.2 +/- 11.4 yrs ) were enrolled in a multicentre controlled study , to evaluate the efficacy and safety of enoxaparin in comparison to calcium heparin in the prevention of deep venous thrombosis ( DVT ) following general surgery . Patients assigned to the enoxaparin and the calcium heparin groups received 1 daily dose of 20 mg ( 2000 I.U . ) and 2 daily doses of 0.2 ml ( 5000 I.U . ) , respectively starting 2 hours before the operation . Both drugs were given by subcutaneous route . A Doppler or Duplex Scan diagnosis of DVT was made in 3 ( 0.5 % ) patients in the enoxaparin group ( 2 cases during treatment and 1 patient at the end of treatment ) and in 6 ( 1.1 % ) patients in the calcium heparin group ( 5 cases during treatment and 1 , bilateral , after the end of treatment ) . Pulmonary embolism ( PE ) was ascertained by angiography in 1 patient ( 0.18 % ) in the enoxaparin group and in 2 patients ( 0.36 % ) in the calcium heparin one . Hemorrhagic complications occurred in 29 patients ( 5.2 % ) in the enoxaparin group and in 34 ( 6.1 % ) in the calcium heparin group . Haematomas located in the injection site were reported in 16.1 % and 25.3 % in the enoxaparin and calcium heparin groups respectively ( p = 0.0001 ) . Local pain in the injection site at the 5th day of treatment was reported in 8.4 % and 16.6 % in the enoxaparin and calcium heparin groups respectively ( p = 0.0001 ) . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
Enoxaparin
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Intervention_Pharmacological
LMWHs
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Intervention_Pharmacological
enoxaparin
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Intervention_Pharmacological
calcium heparin
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Intervention_Pharmacological
enoxaparin
84984
Intervention_Pharmacological
calcium heparin
84985
Intervention_Pharmacological
enoxaparin
84986
Intervention_Pharmacological
calcium heparin
84987
Intervention_Pharmacological
enoxaparin
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Intervention_Pharmacological
calcium heparin
84989
Intervention_Pharmacological
enoxaparin
84990
Intervention_Pharmacological
calcium heparin
84991
Intervention_Pharmacological
enoxaparin
84992
Intervention_Pharmacological
calcium heparin
84993
Outcome_Physical
venous thrombosis
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Outcome_Physical
DVT
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Outcome_Physical
post surgical thromboembolism .
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Outcome_Physical
deep venous thrombosis ( DVT )
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Outcome_Physical
DVT
84998
Outcome_Physical
Pulmonary embolism ( PE )
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Outcome_Physical
Hemorrhagic complications
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Outcome_Physical
Haematomas
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Participant_Condition
major surgery
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Participant_Sample-size
One thousand one hundred and twenty-two patients
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Participant_Sample-size
533
85004
Participant_Sample-size
589
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Participant_Age
mean age 62.2 +/- 11.4 yrs