19709
document
[ Study on treatment of iron-deficiency anemia by shengxuening ] . OBJECTIVE To observe the therapeutic effect of shengxuening ( SXN ) in treating iron-deficiency anemia ( IDA ) and to explore its molecular mechanism on iron metabolism balance regulation . METHODS Patients with IDA were randomly divided into the treated group and the control group , 50 in each group . They were treated with SXN ( 0.1 g , three times per day ) and ferrous gluconate ( 0.1 g , three times per day ) respectively , for 30 days . Levels of serum iron ( Fe ) , total iron binding capacity ( TIBC ) , transferrin saturation ( TS ) , serum ferritin ( SF ) , transferrin ( Tf ) , soluble transferrin receptor ( sTfR ) and blood routine test , as well as scoring of TCM qi-blood deficiency Syndrome were conducted before and after treatment . RESULTS The total effective rate in the treated group reached 92 % , it was shown that SXN could improve the iron metabolism , increase levels of Fe , TS , SF and reduce levels of TIBC , Tf , sTfR , it has obvious effect in promoting erythrocyte generation and could promote formation of leucocytes and platelets . The total effective rate in the control group was 32 % , which was significantly lower than that in the treated group ( P < 0.01 ) . CONCLUSION The effect of SXN in treating IDA and qi-blood deficiency Syndrome is evident , it could improve the iron metabolism , increase levels of Fe , TS , SF and lower levels of TIBC , Tf , sTfR .
19710
Intervention_Pharmacological
shengxuening
19711
Intervention_Pharmacological
shengxuening ( SXN )
19712
Intervention_Control
control
19713
Intervention_Pharmacological
SXN ( 0.1 g , three times per day
19714
Intervention_Pharmacological
ferrous gluconate ( 0.1 g , three times per day
19715
Intervention_Pharmacological
SXN
19716
Outcome_Physical
Levels of serum iron ( Fe ) , total iron binding capacity ( TIBC ) , transferrin saturation ( TS ) , serum ferritin ( SF ) , transferrin ( Tf ) , soluble transferrin receptor ( sTfR ) and blood routine test , as well as scoring of TCM qi-blood deficiency Syndrome
19717
Outcome_Physical
iron metabolism
19718
Outcome_Physical
increase levels of Fe , TS , SF
19719
Outcome_Physical
reduce levels of TIBC , Tf , sTfR
19720
Outcome_Other
total effective rate
19721
Participant_Condition
iron-deficiency anemia
19722
Participant_Condition
IDA
19723
Participant_Sample-size
50