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document
Multiple doses of secretin in the treatment of autism : a controlled study . UNLABELLED Dramatic effects on autistic behaviour after repeated injections of the gastrointestinal hormone secretin have been referred in a number of case reports . In the absence of curative and effective treatments for this disabling condition , this information has created new hope among parents . Although controlled studies on the effect of mainly one single dose have not documented any effect , many children still continue to receive secretin . Six children enrolled in a double-blind , placebo-controlled crossover study in which each child was its own control . Human synthetic secretin , mean dose 3.4 clinical units , and placebo were administered intravenously in randomized order every 4th wk , on three occasions each . The measurement instruments were the visual analogue scale ( VAS ) and the aberrant behaviour checklist ( ABC ) . Statistically significant differences were found for placebo in 3 out of 6 children and for secretin in one child , using parental ratings only ( VAS scores ) . Differences were small and lacked clinical significance , which was in accordance with the overall impression of the parents and teachers and visual inspection of graphs . CONCLUSION In this placebo-controlled study , multiple doses of secretin did not produce any symptomatic improvement .
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Intervention_Pharmacological
secretin
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Intervention_Pharmacological
secretin
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Intervention_Pharmacological
secretin
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Intervention_Pharmacological
Human synthetic secretin
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Intervention_Control
placebo
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Intervention_Pharmacological
secretin
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Outcome_Mental
visual analogue scale ( VAS ) and the aberrant behaviour checklist ( ABC ) .
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Outcome_Mental
parental ratings only ( VAS scores )
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Participant_Condition
autism
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Participant_Age
children
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Participant_Sample-size
Six
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Participant_Age
children