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document
[ Clinical benefits of normothermic cardiopulmonary bypass on postoperative systemic metabolism ] . To evaluate the influence of body temperature during cardiopulmonary bypass ( CPB ) on postoperative systemic metabolism , 32 patients undergoing elective cardiac surgery were randomly assigned to either hypothermia ( n = 16 ) or normothermia ( n = 16 ) . Serial hemodynamic parameters and blood samples were obtained after surgery . CPB and operation times were significantly shorter and the platelet reduction ratio during CPB [ = ( platelets before CPB-platelets after CPB ) /platelets before CPB ] was significantly lower in normothermic patients than in hypothermic patients . The platelet reduction ratio was dependent on the minimum rectal temperature during CPB , the operation time , and the CPB time . In the early postoperative period , hypothermic patients had abnormally high systemic vascular resistance and a reduced cardiac index compared with the normothermic patients . There were no differences between 2 groups in postoperative hepatic and renal functions , changes in oxygen consumption , arterial-venous PCO2 or arterial-venous pH gradient . This study suggested a beneficial influence of normothermic CPB on postoperative hemodynamics . Normothermic CPB was not associated with adverse effects on postoperative metabolic recovery .
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Intervention_Surgical
normothermic cardiopulmonary bypass
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Intervention_Surgical
cardiopulmonary bypass ( CPB )
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Intervention_Surgical
hypothermia
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Intervention_Surgical
normothermia
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Intervention_Surgical
CPB
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Intervention_Surgical
CPB
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Intervention_Surgical
normothermic CPB
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Intervention_Surgical
Normothermic CPB
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Outcome_Physical
postoperative systemic metabolism
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Outcome_Other
CPB and operation times
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Outcome_Physical
platelet reduction ratio
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Outcome_Physical
platelet reduction ratio
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Outcome_Other
operation time
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Outcome_Physical
CPB time
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Outcome_Physical
high systemic vascular resistance and a reduced cardiac index
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Outcome_Physical
normothermic patients
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Outcome_Physical
postoperative hepatic and renal functions
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Outcome_Physical
changes in oxygen consumption
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Outcome_Physical
arterial-venous PCO2 or arterial-venous pH gradient
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Outcome_Physical
postoperative hemodynamics
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Outcome_Adverse-effects
adverse effects
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Participant_Sample-size
32
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Participant_Condition
elective cardiac surgery
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Participant_Condition
hypothermia
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Participant_Sample-size
n = 16
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Participant_Condition
normothermia