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document
Depressive mood symptoms associated with ovarian suppression . OBJECTIVE To determine if sertraline is helpful in the management of depressive symptoms associated with ovarian suppression during GnRH agonist therapy as compared with a placebo-controlled group . DESIGN Double-blind placebo-controlled prospective study design . SETTING An obstetrics/gynecological office specializing in infertility in an academic environment . PATIENT ( S ) Premenstrual women with laparoscopically diagnosed endometriosis who required GnRH agonist therapy for treatment and did not have significant depressive or premenstrual mood symptoms at baseline . INTERVENTION ( S ) Participants were randomly assigned to either the sertraline treatment group or to the placebo group for the 3-month duration of the GnRH agonist therapy . MAIN OUTCOME MEASURE ( S ) The 21-item Hamilton Rating Scale for Depression ( HRSD ) , which is an instrument designed to assess depressive symptomatology . RESULT ( S ) A Hotellings T ( 2 ) test for repeated measure analysis indicated a statistically significant ( P < .05 ) between-group difference across time for the HRSD ( T ( 2 ) = 13.3 ; F [ 3 , 28 ] = 4.1 ; P=.02 ) with the sertraline treatment group manifesting significantly fewer depressive symptoms than the control group . CONCLUSION ( S ) The results indicate that sertraline is an effective option in the management of depressive mood symptoms associated with ovarian suppression during GnRH agonist therapy .
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Intervention_Pharmacological
sertraline
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Intervention_Pharmacological
GnRH agonist therapy
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Intervention_Control
placebo-controlled
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Intervention_Physical
GnRH agonist therapy
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Intervention_Control
sertraline treatment
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Intervention_Physical
GnRH agonist therapy .
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Intervention_Pharmacological
sertraline
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Intervention_Pharmacological
sertraline
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Intervention_Physical
GnRH agonist therapy .
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Outcome_Mental
The 21-item Hamilton Rating Scale for Depression ( HRSD )
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Outcome_Mental
depressive symptoms
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Participant_Sex
women
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Participant_Condition
laparoscopically diagnosed endometriosis
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Participant_Condition
required GnRH agonist therapy
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Participant_Condition
did not have significant depressive or premenstrual mood symptoms at baseline .