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document
Differential effects of two dihydropyridine calcium antagonists in humans . We studied the effects after single doses of niguldipine ( 0.3 , 0.6 , and 0.9 mg intravenously ; 8 and 16 mg orally ) and nifedipine ( 2 mg intravenously ; 20 mg orally ) in healthy male volunteers in randomized placebo-controlled experiments . Total peripheral resistance ( TPR ) , heart rate-corrected electromechanical systole ( QS2c ) , and preejection period ( PEPc ) were assessed noninvasively . Both drugs induced a similar pronounced decreased in TRP , indicating peripheral vasodilation , followed by increasing heart rate and cardiac output , a decrease in diastolic blood pressure , and a shortening of the PEPc . QS2c was unchanged after niguldipine . The prolongation of QS2c after oral nifedipine is suggestive of a negative inotropic effect . We conclude that the vasodilatory effects of dihydropyridines may ( as for nifedipine ) or may not ( as for niguldipine ) be associated with changes that are suggestive of negative inotropic effects , and that this difference is detectable by noninvasive methods in healthy subjects .
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Intervention_Pharmacological
dihydropyridine calcium antagonists
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Intervention_Pharmacological
niguldipine
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Intervention_Pharmacological
nifedipine
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
nifedipine
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Intervention_Pharmacological
dihydropyridines
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Intervention_Pharmacological
nifedipine
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Intervention_Pharmacological
niguldipine
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Outcome_Other
Differential effects
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Outcome_Physical
Total peripheral resistance ( TPR )
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Outcome_Physical
heart rate-corrected electromechanical systole ( QS2c )
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Outcome_Physical
preejection period ( PEPc )
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Outcome_Physical
heart rate
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Outcome_Physical
cardiac output
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Outcome_Physical
prolongation of QS2c
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Outcome_Physical
negative inotropic effect
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Outcome_Physical
vasodilatory effects
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Outcome_Other
negative inotropic effects
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Participant_Condition
healthy male volunteers