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document
Impact of antioxidants , zinc , and copper on cognition in the elderly : a randomized , controlled trial . Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants ( vitamin C , 500 mg ; vitamin E , 400 IU ; beta carotene , 15 mg ) , zinc and copper ( zinc , 80 mg ; cupric oxide , 2 mg ) , antioxidants plus zinc and copper , or placebo . A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment . Treatment groups did not differ on any of the six cognitive tests ( p > 0.05 for all ) . These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults .
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Intervention_Pharmacological
antioxidants
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Intervention_Pharmacological
zinc
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Intervention_Pharmacological
copper
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Intervention_Pharmacological
antioxidants
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Intervention_Pharmacological
vitamin C
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Intervention_Pharmacological
vitamin E , 400 IU
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Intervention_Pharmacological
beta carotene , 15 mg
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Intervention_Pharmacological
zinc
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Intervention_Pharmacological
copper ( zinc , 80 mg
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Intervention_Pharmacological
cupric oxide , 2 mg
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Intervention_Pharmacological
antioxidants plus zinc
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Intervention_Pharmacological
copper
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Intervention_Control
placebo
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Intervention_Pharmacological
antioxidants or zinc
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Intervention_Pharmacological
copper
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Outcome_Mental
six cognitive tests
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Outcome_Other
beneficial or harmful effect of antioxidants or zinc and copper
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Outcome_Mental
cognition