90416
document
Dose-response and concentration-response relation of rocuronium infusion during propofol-nitrous oxide and isoflurane-nitrous oxide anaesthesia . The dose-response and concentration-response relation of rocuronium infusion was studied in 20 adult surgical patients during propofol-nitrous oxide and isoflurane ( 1 MAC ) -nitrous oxide anaesthesia . Neuromuscular block was kept constant , initially at 90 % and then at 50 % with a closed-loop feedback controller . At 90 % block the steady-state infusion of rocuronium was 0.55 +/- 0.16 mg kg-1 h-1 and the corresponding concentration 1714 +/- 281 ng mL-1 in patients receiving propofol . At 50 % block the corresponding infusion rate was 0.27 +/- 0.11 mg kg-1 h-1 and the concentration 1077 +/- 244 ng mL-1 , respectively . At 50 % block isoflurane reduced the rate of infusion by 52 % ( P < 0.005 ) and the concentration by 59 % ( P < 0.001 ) ; at 90 % block both the mean infusion rate and the concentration of rocuronium were reduced by 35 % ( P < 0.005 ) . The mean rocuronium clearance at 50 % block was unaffected by the type of anaesthesia ; it was 4.1 +/- 1.6 and 4.9 +/- 2.7 mL kg-1 min-1 in the groups receiving propofol and isoflurane anaesthesia , respectively . We conclude that isoflurane reduces the infusion requirements of rocuronium by changing the pharmacodynamic behaviour .
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Intervention_Pharmacological
rocuronium infusion
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Intervention_Pharmacological
propofol-nitrous oxide
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Intervention_Pharmacological
isoflurane-nitrous oxide anaesthesia
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Intervention_Pharmacological
rocuronium infusion
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Intervention_Pharmacological
propofol-nitrous oxide
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Intervention_Pharmacological
isoflurane ( 1 MAC ) -nitrous oxide anaesthesia
90423
Intervention_Physical
closed-loop feedback controller
90424
Intervention_Pharmacological
steady-state infusion of rocuronium
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Intervention_Pharmacological
propofol
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Intervention_Pharmacological
isoflurane
90427
Intervention_Pharmacological
rocuronium
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Intervention_Pharmacological
anaesthesia
90429
Intervention_Pharmacological
propofol
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Intervention_Pharmacological
isoflurane anaesthesia
90431
Intervention_Pharmacological
rocuronium
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Outcome_Other
Dose-response and concentration-response
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Outcome_Other
The dose-response and concentration-response relation
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Outcome_Other
steady-state infusion
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Outcome_Other
concentration
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Outcome_Other
corresponding infusion rate
90437
Outcome_Other
concentration
90438
Outcome_Other
rate of infusion
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Outcome_Other
concentration
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Outcome_Other
mean infusion rate
90441
Outcome_Other
concentration of rocuronium
90442
Outcome_Other
mean rocuronium clearance
90443
Outcome_Other
infusion requirements of rocuronium