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document
Immunogenicity and reactogenicity of a group C meningococcal conjugate vaccine compared with a group A+C meningococcal polysaccharide vaccine in adolescents in a randomised observer-blind controlled trial . This study evaluated the immunogenicity and reactogenicity of a group C meningococcal conjugate vaccine ( MenC ) compared with a group A+C meningococcal polysaccharide vaccine ( MenPS ) in healthy adolescents . Subjects were randomised to receive one dose of either MenC ( n=92 ) or MenPS ( n=90 ) . Group C meningococcal IgG antibody concentrations and bactericidal titres were higher in the MenC group than the MenPS group at 1 month ( 22.8 U/ml vs 4.0 U/ml , p < 0.001 , and 87 vs 20 , p < 0.001 , respectively ) and 12 months ( 6.1 U/ml vs 3.0 U/ml , p < 0.001 , and 81.3 vs 20.2 , p < 0.001 , respectively ) . No differences in post immunisation reaction rates were noted between the two vaccinated groups . This study demonstrated the safety and enhanced immunogenicity of the candidate meningococcal conjugate vaccine as compared with the licensed polysaccharide vaccine in adolescents .
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Intervention_Pharmacological
group C meningococcal conjugate vaccine ( MenC ) compared with a group A+C meningococcal polysaccharide vaccine ( MenPS )
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Intervention_Pharmacological
MenC
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Intervention_Pharmacological
MenPS
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Outcome_Physical
Immunogenicity
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Outcome_Physical
reactogenicity
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Outcome_Physical
immunogenicity
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Outcome_Physical
reactogenicity
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Outcome_Physical
meningococcal IgG antibody concentrations and bactericidal titres
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Outcome_Physical
post immunisation reaction rates
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Outcome_Physical
immunogenicity
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Participant_Condition
adolescents