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document
Comparison of the hypotensive effects of bendrofluazide , bumetanide and xipamide . A randomized , triple crossover study was carried out in 24 elderly patients requiring chronic diuretic therapy to assess the different hypotensive effects of a fixed daily dose of 5 mg bendrofluazide , 1 mg bumetanide and 40 mg xipamide . Each treatment was given for 3 months . The results showed that no significant weight change took place during the study period . There was , however , a significant ( p less than 0.001 ) decrease compared to baseline values both in systolic and diastolic blood pressure during the xipamide period and a decrease in diastolic blood pressure ( p less than 0.05 ) when taking bumetanide . Only minor side-effects were reported .
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Intervention_Pharmacological
bendrofluazide
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Intervention_Pharmacological
bumetanide
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Intervention_Pharmacological
xipamide
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Intervention_Pharmacological
chronic diuretic therapy
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Intervention_Pharmacological
5 mg bendrofluazide
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Intervention_Pharmacological
1 mg bumetanide
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Intervention_Pharmacological
40 mg xipamide
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Intervention_Pharmacological
bumetanide
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Outcome_Physical
weight change
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Outcome_Physical
baseline values both in systolic and diastolic blood pressure
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Outcome_Physical
diastolic blood pressure
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Outcome_Adverse-effects
minor side-effects
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Participant_Sample-size
24
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Participant_Age
elderly
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Participant_Condition
requiring chronic diuretic therapy