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[ Treatment of hyperhomocysteinemia and endothelial dysfunction in renal-transplant recipients with vitamin B ] . OBJECTIVE To study the effect of vitamin B on treatment of hyperhomocysteinemia and endothelial dysfunction in renal-transplant recipients . METHODS Thirty-six stable hyperhomocysteinemic renal-transplant recipients were randomly assigned to vitamin treatment ( group A , n = 18 , folic acid 5 mg/d , vitamin B ( 6 ) 50 mg/d , B ( 12 ) 1000 microg/d ) or controlled group ( group B , n = 18 ) for 6 months . All subjects underwent assessment of levels for creatinine , creatinine clearance , average pressure , total cholesterol , triglyceride and fasting homocysteine . Endothelial function was evaluated using high-resolution vascular ultrasound . RESULTS The levels of homocysteine markedly decreased in group A [ ( 13 +/- 4 ) micromol/L vs ( 20 +/- 5 ) micromol/L , t = 5.3 , P < 0.01 ] after treatment , whereas no significant changes were observed in group B . In group A , endothelium dependent [ ( 12 +/- 5 ) % vs ( 9 +/- 5 ) % , t = 2.9 , P < 0.01 ] and independent [ ( 18 +/- 4 ) % vs ( 12 +/- 5 ) % , t = 3.4 , P < 0.01 ] vasodilatation responses significantly increased after treatment , no significant changes were observed in group B. Endothelium dependent [ ( 9 +/- 6 ) % , t = 2.8 , P < 0.01 ] and independent [ ( 12 +/- 5 ) % , t = 3.5 , P < 0.01 ] vasodilatation responses of group A were significantly lower than that of group B after treatment . CONCLUSIONS Vitamin B supplementation can reduce the levels of homocysteine and improve the endothelial function in hyperhomocysteinemic renal-transplant recipients .
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Intervention_Pharmacological
vitamin treatment ( group A , n = 18 , folic acid 5 mg/d , vitamin B ( 6 ) 50 mg/d , B ( 12 ) 1000 microg/d )
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Intervention_Control
controlled group
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Intervention_Pharmacological
All subjects underwent assessment of levels for creatinine , creatinine clearance , average pressure , total cholesterol , triglyceride and fasting homocysteine .
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Outcome_Other
effect
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Outcome_Physical
levels for creatinine , creatinine clearance , average pressure , total cholesterol , triglyceride and fasting homocysteine . Endothelial function
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Outcome_Physical
vasodilatation responses
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Outcome_Physical
vasodilatation responses
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Participant_Condition
renal-transplant recipients
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Participant_Condition
renal-transplant recipients .
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Participant_Condition
hyperhomocysteinemic renal-transplant recipients .