26369
document
Neurocognitive outcomes in off-pump versus on-pump bypass surgery : a randomized controlled trial . BACKGROUND Cognitive difficulties have been reported after coronary artery bypass graft surgery using cardiopulmonary bypass . However , the cognitive benefit of off-pump surgery remains unclear . METHODS Consecutively listed candidates for elective bypass were randomly assigned to either off-pump or on-pump techniques ( n = 107 ) . A battery of 11 standardized neuropsychological tests was administered before surgery , and again at 2 and 6 months after surgery . The two groups were compared using a range of statistical procedures , including growth modeling . RESULTS There were no significant differences in cognitive test scores between the off-pump and on-pump groups using t tests at any of the time points . There were no differences between off-pump and on-pump groups in the incidence of cognitive deficits at 2 months or 6 months , with the exception that fewer off-pump patients showed impairment on one test of verbal fluency at 6 months . When the pattern of cognitive change over time between the two groups was compared using sophisticated modeling techniques , the two groups were again comparable , except for results on the test of verbal fluency , in which the off-pump group showed more rapid postsurgical cognitive gains than the on-pump group . CONCLUSIONS The off-pump group appears to be generally comparable to the on-pump group in terms of short-term and long-term postsurgical neurocognitive outcomes .
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Intervention_Surgical
off-pump
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Intervention_Surgical
on-pump bypass surgery
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Intervention_Surgical
cardiopulmonary bypass
26373
Intervention_Surgical
off-pump
26374
Intervention_Surgical
on-pump
26375
Intervention_Surgical
off-pump
26376
Intervention_Surgical
on-pump
26377
Intervention_Surgical
off-pump
26378
Intervention_Surgical
on-pump
26379
Intervention_Surgical
off-pump
26380
Intervention_Surgical
off-pump
26381
Intervention_Surgical
on-pump
26382
Intervention_Surgical
off-pump
26383
Intervention_Surgical
on-pump
26384
Outcome_Physical
Neurocognitive outcomes
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Outcome_Physical
growth modeling
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Outcome_Physical
cognitive test scores
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Outcome_Physical
incidence of cognitive deficits
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Outcome_Mental
verbal fluency
26389
Outcome_Physical
pattern of cognitive change over time
26390
Outcome_Mental
verbal fluency
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Outcome_Physical
cognitive gains
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Participant_Condition
after coronary artery bypass graft surgery using cardiopulmonary bypass .
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Participant_Condition
Consecutively listed candidates for elective bypass
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Participant_Condition
( n = 107 )