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document
Effect of fats high in individual saturated fatty acids on plasma lipoprotein [ a ] levels in young healthy men . Plasma lipoprotein [ a ] ( Lp [ a ] ) is associated with atherogenesis and thrombogenesis . We examined how plasma Lp [ a ] in healthy young men was affected by fats high in stearic ( C18 ) , palmitic ( C16 ) , and lauric+myristic ( C12+ C14 ) acid ( experiment I , 15 subjects ) , and by fats high in myristic ( C14 ) and palmitic ( C16 ) acid ( experiment II , 12 subjects ) . Strictly controlled isocaloric diets with 36 % of energy from test fats were served in random order for 3 weeks separated by wash-out period ( s ) . Diets high in C18 gave significantly higher levels of Lp [ a ] ( 51 ( 12-560 ) mg/L ) than diets high in C16 ( 38 ( 12-533 mg/L ) ( P = 0.020 ) and C12 + C14 ( 34 ( 12-534 ) mg/L ) ( P = 0.002 ) . These differences were observed in several of the subjects in experiment I . In experiment II we saw no difference in plasma Lp [ a ] after diets high in C16 and C14 . Our observations suggest that a fat high in stearic acid might affect Lp [ a ] in a different way than fats high in palmitic and myristic+lauric acid . Lp [ a ] concentrations were not associate with changes in tissue-plasminogen activator ( t-PA ) activity , factor VII coagualant activity , or plasma LDL cholesterol .
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Intervention_Pharmacological
fats
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Intervention_Pharmacological
fats high in stearic ( C18 ) , palmitic ( C16 ) , and lauric+myristic ( C12+ C14 ) acid
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Intervention_Pharmacological
and by fats high in myristic ( C14 ) and palmitic ( C16 ) acid ( experiment
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Intervention_Pharmacological
isocaloric diets
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Intervention_Physical
Diets high in C18
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Intervention_Physical
high in C16
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Outcome_Physical
plasma lipoprotein [ a ] levels
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Outcome_Physical
Plasma lipoprotein [ a ] ( Lp [ a ] )
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Outcome_Physical
levels of Lp [ a ]
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Outcome_Physical
differences
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Outcome_Physical
plasma Lp [ a ]
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Outcome_Physical
Lp [ a ]
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Outcome_Physical
Lp [ a ] concentrations
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Outcome_Physical
tissue-plasminogen activator ( t-PA ) activity
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Outcome_Physical
factor VII coagualant activity
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Outcome_Physical
plasma LDL cholesterol
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Participant_Age
young
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Participant_Condition
healthy
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Participant_Sex
men
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Participant_Sample-size
experiment I , 15 subjects
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Participant_Sample-size
experiment II , 12 subjects