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document
Onset/offset characteristics and intubating conditions of rapacuronium : a comparison with rocuronium . We compared onset and offset of action and tracheal intubating conditions after rapacuronium and rocuronium in 60 patients in a randomized , assessor-blinded study . Following induction of anaesthesia with propofol 2.5 mg kg-1 , either rapacuronium 1.5 mg kg-1 ( n = 30 ) or rocuronium 0.6 mg kg-1 ( n = 30 ) was administered to facilitate tracheal intubation . Anaesthesia was maintained with either a propofol infusion ( 100 micrograms kg-1 min-1 ) or sevoflurane ( 1 % end-tidal ) with 66 % nitrous oxide ( N2O ) , n = 15 in each subgroup . Neuromuscular monitoring was performed using an electromyographic ( EMG ) device ( Datex Relaxograph ) . The lag times ( mean 42 ( SD 11 ) s and 44 ( 16 ) s ) , maximum block ( 99 ( 2 ) % and 98 ( 3 ) % ) and intubating conditions at 60 s ( good-to-excellent in 86 % and 84 % of patients ) were similar for rapacuronium and rocuronium , respectively . The onset time of rapacuronium was shorter than rocuronium ( 87 ( 20 ) vs 141 ( 65 ) s , P < 0.001 ) , and the degree of block at 60 s was greater ( 69 ( 26 ) vs 50 ( 27 ) % , P < 0.05 ) . Twenty-five per cent recovery was shorter with rapacuronium than rocuronium during propofol ( 15.0 ( 3.2 ) vs 39.1 ( 14.2 ) min , P < 0.001 ) and sevoflurane ( 15.1 ( 4.2 ) vs 47.8 ( 19.0 ) min , P < 0.001 ) anaesthesia . We conclude that rapacuronium 1.5 mg kg-1 had a more rapid onset , similar intubating conditions , and shorter recovery times than rocuronium 0.6 mg kg-1 .
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Intervention_Pharmacological
rapacuronium
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Intervention_Pharmacological
rocuronium
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Intervention_Physical
propofol
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Intervention_Pharmacological
rapacuronium
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Intervention_Pharmacological
rocuronium
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Intervention_Physical
propofol infusion ( 100
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Intervention_Pharmacological
micrograms
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Intervention_Physical
kg-1 min-1 )
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Intervention_Pharmacological
sevoflurane ( 1 % end-tidal ) with 66 % nitrous oxide ( N2O )
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Intervention_Physical
Neuromuscular monitoring
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Intervention_Physical
electromyographic
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Outcome_Physical
Onset/offset characteristics and intubating conditions
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Outcome_Physical
onset and offset of action and tracheal intubating conditions
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Outcome_Other
Neuromuscular monitoring
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Outcome_Other
lag times
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Outcome_Other
maximum block
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Outcome_Physical
intubating conditions at 60 s
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Outcome_Other
onset time
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Outcome_Physical
degree of block at 60 s
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Outcome_Physical
recovery
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Outcome_Physical
intubating conditions
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Participant_Condition
tracheal intubating conditions
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Participant_Sample-size
60
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Participant_Condition
patients