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document
7-hexanoyltaxol-eluting stent for prevention of neointimal growth : an intravascular ultrasound analysis from the Study to COmpare REstenosis rate between QueST and QuaDS-QP2 ( SCORE ) . BACKGROUND Inhibition of neointimal tissue growth has been demonstrated in preliminary human feasibility studies with a stent-based polymer sleeve delivering 7-hexanoyltaxol . The Study to COmpare REstenosis rate between QueST and QuaDS-QP2 ( SCORE ) trial is a human , randomized , multicenter trial comparing 7-hexanoyltaxol ( QP2 ) -eluting stents ( qDES ) with bare metal stents ( BMS ) in the treatment of de novo coronary lesions . The purpose of this substudy was to evaluate the acute expansion property and long-term neointimal responses of qDES compared with BMS as assessed by intravascular ultrasound ( IVUS ) . METHODS AND RESULTS A total of 122 ( qDES 66 , BMS 56 ) patients were enrolled into the IVUS substudy . All IVUS images ( immediately after the procedure and at 6-month follow-up ) were analyzed at an independent core laboratory in a blind manner . At baseline , qDES achieved stent expansion similar to BMS . At follow-up , qDES showed reduced neointimal growth by 70 % at the tightest cross section and by 68 % over the stented segment ( P < 0.0001 for both ) , resulting in a significantly larger lumen in qDES than in BMS . Unlike intracoronary brachytherapy , there was no evidence of negative edge effects , unhealed dissections , or late stent-vessel wall malapposition over the stented and adjacent references segments in either group . CONCLUSIONS Detailed IVUS analysis revealed that qDES had comparable acute mechanical and superior long-term biological effects to BMS . Although the long-term benefits and limitations of this technology require further investigation , the reduction in neointimal thickenings demonstrated that local delivery of 7-hexanoyltaxol through polymer sleeves augments conventional mechanical treatment of atherosclerotic disease .
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Intervention_Surgical
7-hexanoyltaxol-eluting stent
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Intervention_Surgical
stent-based polymer sleeve
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Intervention_Pharmacological
7-hexanoyltaxol
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Intervention_Surgical
7-hexanoyltaxol ( QP2 ) -eluting stents ( qDES ) with bare metal stents ( BMS )
10658
Intervention_Surgical
qDES
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Intervention_Physical
BMS
10660
Intervention_Surgical
qDES
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Intervention_Surgical
qDES
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Intervention_Surgical
qDES
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Intervention_Surgical
BMS
10664
Intervention_Pharmacological
7-hexanoyltaxol
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Outcome_Physical
acute expansion property
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Outcome_Physical
long-term neointimal responses
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Outcome_Physical
stent expansion
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Outcome_Physical
neointimal growth
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Outcome_Adverse-effects
negative edge effects
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Outcome_Adverse-effects
unhealed dissections
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Outcome_Adverse-effects
late stent-vessel wall malapposition
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Participant_Condition
treatment of de novo coronary lesions
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Participant_Sample-size
122
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Participant_Sample-size
qDES 66
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Participant_Sample-size
BMS 56
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Participant_Condition
atherosclerotic disease