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document
Topical treatment of tinea pedis using 6 % coriander oil in unguentum leniens : a randomized , controlled , comparative pilot study . BACKGROUND The antifungal activity of coriander oil has already been demonstrated in vitro . OBJECTIVE Evaluation of the efficacy and tolerability of 6 % coriander oil in unguentum leniens in the treatment of interdigital tinea pedis . METHODS Half-side comparative pilot study on subjects with symmetric , bilateral interdigital tinea pedis . Active drug and placebo control were applied twice daily on the affected areas , and follow-up visits were performed on days 14 and 28 . RESULTS 40 participants ( mean age 52.5 years , 60 % male ) were included in the study . For 6 % coriander oil in unguentum leniens , a highly significant improvement of the clinical signs ( p < 0.0001 ) was observed during the entire observation period ; the number of positive fungal cultures also tended to decrease ( p = 0.0654 ) . The tolerability of the tested substances was good . CONCLUSION Coriander oil is effective and well tolerated in the treatment of interdigital tinea pedis .
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Intervention_Pharmacological
coriander oil
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Intervention_Pharmacological
coriander oil
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Intervention_Pharmacological
6 % coriander oil
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Intervention_Control
placebo
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Intervention_Pharmacological
Coriander oil
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Outcome_Other
efficacy
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Outcome_Other
tolerability
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Outcome_Other
clinical signs
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Outcome_Physical
number of positive fungal cultures
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Outcome_Other
tolerability