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document
The influence of beta-adrenoceptor blockade on left ventricular function . 1 This study was designed to compare in a randomized cross-over trial pindolol , a beta-adrenoceptor blocking agent with intrinsic sympathomimetic activity and metoprolol , a cardioselective beta-adrenoceptor blocker lacking sympathomimetic activity in hypertensives with incipient heart failure . Cardiac function was investigated by M-Mode and 2D-echo-cardiography . 2 Both pindolol and metoprolol in equipotent doses lowered blood pressure to the same extent . 3 There was no difference in overall left ventricular function in ventricular geometry or in wall dynamics after either drug . 4 In comparison to metoprolol , pindolol produced less reduction in resting heart rate , cardiac index and ejection velocity reflecting the intrinsic sympathomimetic activity of the drug .
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Intervention_Pharmacological
beta-adrenoceptor
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Intervention_Pharmacological
pindolol
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Intervention_Pharmacological
beta-adrenoceptor blocking agent
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Intervention_Pharmacological
metoprolol
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Intervention_Pharmacological
pindolol
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Intervention_Pharmacological
metoprolol
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Intervention_Pharmacological
metoprolol
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Intervention_Pharmacological
pindolol
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Outcome_Physical
Cardiac function
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Outcome_Other
M-Mode and 2D-echo-cardiography
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Outcome_Physical
blood pressure
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Outcome_Physical
overall left ventricular function in ventricular geometry or in wall dynamics
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Outcome_Physical
resting heart rate , cardiac index and ejection velocity
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Participant_Condition
incipient heart failure