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document
Midazolam vs ondansetron for preventing postoperative nausea and vomiting : a randomised controlled trial . We compared the prophylactic anti-emetic efficacy of midazolam and ondansetron in 90 patients scheduled for minor gynaecological ( hysteroscopy ) or urological ( ureteroscopy ) procedures planned to last 1-2 h under sevoflurane anaesthesia with spontaneous ventilation of the lungs via a laryngeal mask airway . Midazolam 2 mg or ondansetron 4 mg were administered intravenously 30 min before the end of surgery . The proportions of patients who experienced postoperative nausea and vomiting in the first 24 h ( 30 % and 27 % for the midazolam and ondansetron groups , respectively ) were similar in the two groups . The incidence of postoperative nausea and vomiting was significantly smaller in both groups than predicted according to the patients ' underlying risks ( midazolam group : p = 0.018 ; ondansetron group : p = 0.017 ) . There were no significant differences in average sedation scores or pain scores . Treatment using ondansetron for anti-emetic prophylaxis did not provide a superior benefit compared to midazolam in the present study .
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Intervention_Pharmacological
Midazolam
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Intervention_Pharmacological
ondansetron
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Intervention_Pharmacological
midazolam
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Intervention_Pharmacological
ondansetron
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Intervention_Pharmacological
Midazolam 2 mg
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Intervention_Pharmacological
ondansetron 4 mg
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Intervention_Pharmacological
midazolam
29018
Intervention_Pharmacological
ondansetron
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Intervention_Pharmacological
midazolam
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Intervention_Pharmacological
ondansetron
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Intervention_Pharmacological
ondansetron
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Intervention_Pharmacological
midazolam
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Outcome_Adverse-effects
postoperative nausea and vomiting
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Outcome_Adverse-effects
postoperative nausea and vomiting
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Outcome_Adverse-effects
postoperative nausea and vomiting
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Outcome_Other
no significant differences
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Outcome_Physical
average sedation scores
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Outcome_Physical
pain scores
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Participant_Sample-size
90 patients
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Participant_Condition
minor gynaecological ( hysteroscopy ) or urological ( ureteroscopy ) procedures
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Participant_Condition
sevoflurane anaesthesia
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Participant_Condition
postoperative nausea and vomiting