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document
Skeletal muscle total creatine content and creatine transporter gene expression in vegetarians prior to and following creatine supplementation . This study examined the effect of vegetarianism on skeletal muscle total creatine ( TCr ) content and creatine transporter ( CreaT ) gene expression , prior to and during 5 d of Cr supplementation ( CrS ) . In a double-blind , crossover design , 7 vegetarians ( VEG ) and nonvegetarians ( NVEG ) were assigned Cr or placebo supplements for 5 d and after 5 wk , received the alternative treatment . Muscle sampling occurred before , and after 1 and 5 d of treatment ingestion . Basal muscle TCr content was lower ( P < 0.05 ) in VEG compared with NVEG . Muscle TCr increased ( P < 0.05 ) throughout the Cr trial in both groups but was greater ( P < 0.05 ) in VEG compared with NVEG , at days 1 and 5 . CreaT gene expression was not different between VEG and NVEG . The results indicate that VEG have a lower muscle TCr content and an increased capacity to load Cr into muscle following CrS . Muscle CreaT gene expression does not appear to be affected by vegetarianism .
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Intervention_Pharmacological
creatine supplementation
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Intervention_Pharmacological
Cr supplementation ( CrS )
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Intervention_Pharmacological
Cr
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Intervention_Control
placebo supplements
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Intervention_Physical
Muscle sampling
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Intervention_Pharmacological
Cr
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Intervention_Pharmacological
CrS
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Outcome_Physical
skeletal muscle total creatine ( TCr ) content
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Outcome_Physical
creatine transporter ( CreaT ) gene expression
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Outcome_Physical
Basal muscle TCr
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Outcome_Physical
CreaT gene expression
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Outcome_Physical
muscle TCr content
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Outcome_Physical
capacity
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Outcome_Physical
Muscle CreaT gene expression
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Participant_Condition
vegetarians