19771
document
Use of abciximab prior to primary angioplasty in STEMI results in early recanalization of the infarct-related artery and improved myocardial tissue reperfusion - results of the Austrian multi-centre randomized ReoPro-BRIDGING Study . AIMS The aim of the ReoPro-BRIDGING Austrian multi-centre study was to investigate the effects of abciximab ( ReoPro ) on early reperfusion in ST-elevation myocardial infarction prior to or during primary percutaneous coronary angioplasty ( pPCI ) . METHODS AND RESULTS Fifty-five patients with STEMI were randomized either to start abciximab ( 0.25 mg/kg bolus followed by 10 microg/min infusion ) during the organization phase for pPCI ( Group 1 , n=28 ) or immediately before pPCI ( Group 2 , n=27 ) . The time between first bolus of abciximab and first balloon inflation of pPCI was 83+/-18 vs 21+/-13 min in Group 1 vs 2 . The pre-pPCI ST-segment resolution ( 55+/-21.4 % vs 42.4+/-18.2 % , p=0.005 ) , TIMI flow grade 3 ( 29 % vs 7 % , p=0.042 ) , corrected TIMI frame count ( 58.4+/-32.7 vs 78.9+/-28.4 frame , p=0.018 ) % diameter stenosis ( 76.3 /63.5-100/ vs 100 /73.5-100/ ; median /interquartile range/ , p=0.023 ) , were significantly higher in Group 1 vs Group 2 . Quantitative myocardial dye intensity measurement revealed a significantly higher grade of myocardial tissue perfusion ( 1 /0-9.25/ vs 0 /0-3.0/ grey pixel unit , p=0.048 ) in Group 1 before pPCI . Rapid release of cardiac enzymes was observed in Group 1 as compared with Group 2 : rate of rise of CK was 210+/-209 vs 97+/-95 U/l/h ( p=0.015 ) . QRS score indicated a smaller infarct size in Group 1 ( 4.8+/-3.8 vs 7.6+/-3.5 , p=0.011 ) on day 7 . CONCLUSION The use of abciximab in the organization phase for pPCI results in signs of early recanalization of the infarct-related artery and a subsequent improved myocardial tissue reperfusion .
19772
Intervention_Pharmacological
abciximab
19773
Intervention_Surgical
primary angioplasty
19774
Intervention_Pharmacological
abciximab ( ReoPro )
19775
Intervention_Surgical
percutaneous coronary angioplasty ( pPCI )
19776
Intervention_Pharmacological
abciximab
19777
Intervention_Pharmacological
abciximab
19778
Outcome_Physical
recanalization of the infarct-related artery
19779
Outcome_Physical
myocardial tissue reperfusion
19780
Outcome_Physical
early reperfusion in ST-elevation myocardial infarction
19781
Outcome_Physical
pre-pPCI ST-segment resolution
19782
Outcome_Physical
TIMI flow grade 3
19783
Outcome_Physical
TIMI frame count
19784
Outcome_Physical
% diameter stenosis
19785
Outcome_Physical
myocardial tissue perfusion
19786
Outcome_Physical
cardiac enzymes
19787
Outcome_Physical
rise of CK
19788
Outcome_Other
QRS score
19789
Outcome_Physical
infarct size
19790
Outcome_Physical
signs of early recanalization of the infarct-related artery
19791
Outcome_Physical
myocardial tissue reperfusion
19792
Participant_Condition
STEMI
19793
Participant_Condition
Austrian multi-centre randomized ReoPro-BRIDGING Study .