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document
Bright light therapy in Parkinson 's disease : a pilot study . Several observations suggest a beneficial effect of melatonin antagonism for Parkinson 's disease ( PD ) . Although bright light therapy ( BLT ) suppresses melatonin release and is an established treatment for depression and sleep disturbances , it has not been evaluated in PD . We examined effects of BLT on motor symptoms , depression , and sleep in PD in a randomized placebo-controlled double-blind study in 36 PD patients , using Parkinson 's Disease Rating Scale ( UPDRS ) I-IV , Beck 's Depression Inventory , and Epworth Sleepiness Scale . All patients received BLT for 15 days in the morning , 30 min daily . Illuminance was 7.500 lux in the active treatment group and 950 lux in the placebo group . Although group differences were small , BLT led to significant improvement of tremor , UPDRS I , II , and IV , and depression in the active treatment group but not in the placebo group . It was very well tolerated . Follow up studies in more advanced patient populations employing longer treatment durations are warranted .
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Intervention_Physical
Bright light therapy
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Intervention_Physical
melatonin antagonism
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Intervention_Physical
bright light therapy ( BLT )
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Intervention_Physical
BLT
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Intervention_Control
placebo-controlled
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Intervention_Physical
BLT
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Intervention_Control
placebo
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Intervention_Physical
BLT
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Intervention_Control
placebo
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Outcome_Mental
motor symptoms , depression
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Outcome_Mental
sleep
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Outcome_Mental
Parkinson 's Disease Rating Scale ( UPDRS ) I-IV , Beck 's Depression Inventory
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Outcome_Mental
Epworth Sleepiness Scale
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Outcome_Mental
Illuminance
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Outcome_Mental
improvement of tremor , UPDRS I , II , and IV , and depression
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Outcome_Other
tolerated
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Participant_Condition
Parkinson 's disease :
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Participant_Condition
Parkinson 's disease ( PD )
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Participant_Sample-size
36
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Participant_Condition
PD
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Participant_Condition
Parkinson 's Disease