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document
Long-term efficacy of subcutaneous sumatriptan using a novel self-injector . An open , multicenter study investigated the long-term efficacy , tolerability , and acceptability to patients of subcutaneous sumatriptan 6 mg , administered using a novel cartridge system self-injector , for the acute treatment of migraine . Eighty patients treated all migraine attacks for 6 months at home with a subcutaneous injection of sumatriptan 6 mg. A second injection could be taken after 1 to 24 hours if relief was inadequate , or if the headache recurred , and rescue medication could be taken 1 hour after the second injection . The primary end point was the percentage of attacks in which headache improved from severe or moderate before treatment to mild or absent at 1 hour after the first injection . A total of 1566 attacks were treated by the 80 patients and 69 patients completed 6 months of treatment . Headache relief was reported 1 hour after the first injection in a mean of 78 % of attacks ( 83 % in the first 3 months and 76 % in the second 3 months ) . A second injection was required in a mean of 40 % of attacks , and headache was mild or absent 1 hour after the second injection in a mean of 77 % of attacks . Rescue medication was required after the second injection in a mean of 14 % of attacks . At the end of the study , 87 % of patients said that they would take the medication again , and at each clinic visit over 80 % said that they found the injector easy to use . Adverse events were similar to those reported previously with sumatriptan and were mostly mild to moderate in intensity , short-lived , and resolved spontaneously . Subcutaneous sumatriptan 6 mg is an effective , well tolerated , and well accepted , long-term , acute treatment for migraine when self-injected by patients using the novel self-injector .
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Intervention_Pharmacological
subcutaneous sumatriptan
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Intervention_Pharmacological
sumatriptan
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Intervention_Pharmacological
injection of sumatriptan 6 mg.
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Intervention_Pharmacological
sumatriptan
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Intervention_Pharmacological
sumatriptan
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Outcome_Physical
headache
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Outcome_Physical
Headache relief
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Outcome_Physical
headache
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Outcome_Physical
Rescue medication
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Participant_Condition
migraine
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Participant_Sample-size
Eighty
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Participant_Condition
migraine
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Participant_Condition
sumatriptan
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Participant_Sample-size
80
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Participant_Sample-size
69