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document
A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood : a randomized trial . BACKGROUND Recent experimental evidence suggests that gut microbiota may alter function within the nervous system providing new insight on the mechanism of neuropsychiatric disorders . METHODS Seventy-five infants who were randomized to receive Lactobacillus rhamnosus GG ( ATCC 53103 ) or placebo during the first 6 mo of life were followed-up for 13 y . Gut microbiota was assessed at the age of 3 wk , 3 , 6 , 12 , 18 , 24 mo , and 13 y using fluorescein in situ hybridization ( FISH ) and qPCR , and indirectly by determining the blood group secretor type at the age of 13 y . The diagnoses of attention deficit hyperactivity disorder ( ADHD ) and Asperger syndrome ( AS ) by a child neurologist or psychiatrist were based on ICD-10 diagnostic criteria . RESULTS At the age of 13 y , ADHD or AS was diagnosed in 6/35 ( 17.1 % ) children in the placebo and none in the probiotic group ( P = 0.008 ) . The mean ( SD ) numbers of Bifidobacterium species bacteria in feces during the first 6 mo of life was lower in affected children 8.26 ( 1.24 ) log cells/g than in healthy children 9.12 ( 0.64 ) log cells/g ; P = 0.03 . CONCLUSION Probiotic supplementation early in life may reduce the risk of neuropsychiatric disorder development later in childhood possible by mechanisms not limited to gut microbiota composition .
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Intervention_Pharmacological
probiotic intervention
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Intervention_Pharmacological
Lactobacillus rhamnosus GG ( ATCC 53103 )
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Intervention_Control
placebo
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Outcome_Adverse-effects
risk of
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Outcome_Physical
neuropsychiatric disorders
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Outcome_Physical
Gut microbiota
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Outcome_Physical
the blood group secretor type
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Outcome_Physical
of attention deficit hyperactivity disorder ( ADHD ) and Asperger syndrome ( AS )
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Outcome_Mental
y , ADHD
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Outcome_Mental
AS
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Outcome_Physical
The mean ( SD ) numbers of Bifidobacterium species bacteria in feces during the first 6 mo of life
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Outcome_Adverse-effects
the risk of neuropsychiatric disorder development
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Participant_Condition
neuropsychiatric disorders
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Participant_Age
childhood
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Participant_Sample-size
Seventy-five
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Participant_Age
infants
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Participant_Condition
randomized to receive Lactobacillus rhamnosus GG ( ATCC 53103
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Participant_Condition
or placebo during the first
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Participant_Age
childhood