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document
There are some benefits for eradicating Helicobacter pylori in patients with non-ulcer dyspepsia . BACKGROUND The relationship between Helicobacter pylori infection and non-ulcer dyspepsia is not established . AIM To determine whether eradication of H. pylori might be of benefit in non-ulcer dyspepsia patients . METHODS We randomly assigned 129 H. pylori infected patients with severe epigastric pain , without gastro-oesophageal reflux symptoms , to receive twice daily treatment with 300 mg of ranitidine , 1000 mg of amoxicillin , and 500 mg of clarithromycin for 7 days and 124 such patients to receive identical-appearing placebos . RESULTS Treatment was successful ( decrease of symptoms at 12 months ) in 62 % of patients in the active-treatment group and in 60 % of the placebo group ( N.S. ) . At 12 months , the rate of eradication of H. pylori was 69 % in the active-treatment group and 18 % in the placebo group ( P < 0.001 ) . Complete relief of symptoms occurred significantly more frequently in patients on the active treatment ( 43 % ) than in placebo-treated patients ( 31 % , P=0.048 ) . Within the active-treatment group , therapeutic success was significantly more frequent in the non-infected patients ( 84 % vs. 64 % , P=0.04 ) . CONCLUSIONS Although eradicating H. pylori is not likely to relieve symptoms in the majority of patients with non-ulcer dyspepsia , a small proportion of H. pylori-infected patients may benefit from eradication treatment .
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Intervention_Pharmacological
ranitidine
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Intervention_Pharmacological
amoxicillin
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Intervention_Pharmacological
clarithromycin
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Intervention_Control
placebos .
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Outcome_Physical
rate of eradication of H. pylori
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Outcome_Other
Complete relief of symptoms
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Outcome_Other
therapeutic success
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Participant_Condition
non-ulcer dyspepsia
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Participant_Condition
non-ulcer dyspepsia
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Participant_Sample-size
129
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Participant_Condition
pylori infected
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Participant_Condition
severe epigastric pain
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Participant_Condition
without gastro-oesophageal reflux
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Participant_Sample-size
124
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Participant_Condition
non-infected
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Participant_Condition
non-ulcer dyspepsia
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Participant_Condition
pylori-infected