82421
document
[ Carbohydrate substitutes : comparative study of intestinal absorption of fructose , sorbitol and xylitol ] . BACKGROUND The carbohydrate substitutes fructose , sorbitol and xylitol are gaining more and more importance in the production of dietary food . But they can provoke gastrointestinal side-effects . In a randomized double blind study the rate of malabsorption of these sugars was compared and the concomitant symptoms were recorded . SUBJECTS AND METHODS 25 healthy controls received 25 g of each sugar within 3 consecutive days . The intestinal absorption was determined by H2-exhalation tests and the clinical symptoms were recorded . RESULTS The rate of malabsorption was 84 % for sorbitol , 36 % for fructose and 12 % for xylitol ( p < 0.01 for sorbitol versus fructose and xylitol ) . 57 % of the participants with pathological H2-test after sorbitol and 56 % after fructose reported symptoms , while all of the 3 malabsorbers of xylitol were symptomatic . CONCLUSIONS There is an advantage to administering xylitol and fructose with regard to the intestinal absorption and concomitant symptoms as compared with sorbitol . H2-exhalation tests appear to be a reliable diagnostic tool to detect carbohydrate malabsorption and should find broader application in patients suffering from non-specific abdominal complaints .
82422
Intervention_Pharmacological
fructose
82423
Intervention_Pharmacological
sorbitol
82424
Intervention_Pharmacological
xylitol
82425
Intervention_Pharmacological
fructose
82426
Intervention_Pharmacological
sorbitol
82427
Intervention_Pharmacological
xylitol
82428
Intervention_Pharmacological
25 g of each sugar
82429
Intervention_Pharmacological
sorbitol
82430
Intervention_Pharmacological
fructose
82431
Intervention_Pharmacological
xylitol
82432
Intervention_Pharmacological
sorbitol
82433
Intervention_Pharmacological
fructose
82434
Intervention_Pharmacological
xylitol
82435
Intervention_Pharmacological
sorbitol
82436
Intervention_Pharmacological
fructose
82437
Intervention_Pharmacological
xylitol
82438
Intervention_Pharmacological
xylitol
82439
Intervention_Pharmacological
fructose
82440
Intervention_Pharmacological
sorbitol
82441
Outcome_Physical
intestinal absorption was determined by H2-exhalation tests
82442
Outcome_Physical
clinical symptoms
82443
Outcome_Physical
rate of malabsorption
82444
Outcome_Physical
intestinal absorption
82445
Outcome_Physical
carbohydrate malabsorption
82446
Participant_Condition
intestinal absorption of fructose
82447
Participant_Sample-size
25
82448
Participant_Condition
healthy controls