52593
document
Rapid injection of propofol reduces vascular pain and facilitates Laryngeal Mask Airway insertion . STUDY OBJECTIVE To compare the clinical efficacy of a rapid injection of propofol in regard to pain and ability to facilitate Laryngeal Mask Airway ( LMA ) insertion . DESIGN Randomized , single-blinded , placebo-controlled study . SETTING University hospital . PATIENTS 120 ASA physical status 1 and 2 patients undergoing elective orthopedic surgeries . INTERVENTIONS Patients were randomly allocated to one of 4 groups . Group A patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 3.3 mg/sec . Group B patients were pretreated with lidocaine 0.5 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec . In Group C , patients were pretreated with lidocaine 1.0 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec . In Group D , patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 50 mg/sec . MEASUREMENTS Pain on injection was measured using a 4-point scale . Scale and success rate of smooth LMA insertion also were recorded . MAIN RESULTS Rapid injection was less painful than after pretreatment with lidocaine 0.5 mg/kg , but was similar to slow injection after pretreatment with lidocaine 1.0 mg/kg . Rapid injection facilitated LMA insertion , unlike slow injection with lidocaine 0.5 mg/kg pretreatment , and was similarly successful to slow injection after pretreatment with lidocaine 1.0 mg/kg . CONCLUSIONS The rapid administration of propofol reduces pain and facilitates LMA insertion versus slow administration of propofol .
52594
Intervention_Pharmacological
propofol
52595
Intervention_Pharmacological
propofol
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Intervention_Control
placebo-controlled
52597
Intervention_Pharmacological
normal saline followed by propofol 2.0 mg/kg at 3.3 mg/sec .
52598
Intervention_Pharmacological
lidocaine 0.5 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec .
52599
Intervention_Pharmacological
lidocaine 1.0 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec .
52600
Intervention_Pharmacological
normal saline followed by propofol 2.0 mg/kg at 50 mg/sec .
52601
Intervention_Physical
Rapid injection
52602
Intervention_Pharmacological
lidocaine
52603
Intervention_Physical
slow injection
52604
Intervention_Pharmacological
pretreatment with lidocaine
52605
Intervention_Physical
Rapid injection
52606
Intervention_Physical
slow injection
52607
Intervention_Pharmacological
lidocaine
52608
Intervention_Physical
slow injection
52609
Intervention_Pharmacological
after pretreatment with lidocaine
52610
Intervention_Physical
rapid administration
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Intervention_Pharmacological
propofol
52612
Intervention_Physical
slow administration
52613
Intervention_Pharmacological
propofol
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Outcome_Pain
painful
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Outcome_Other
LMA insertion
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Participant_Condition
Laryngeal Mask Airway insertion
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Participant_Condition
LMA
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Participant_Sample-size
120
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Participant_Condition
orthopedic surgeries