57995
document
[ Antiinflammatory potential of seven plant extracts in the ultraviolet erythema test . A randomized , placebo-controlled study ] . BACKGROUND Phytotherapeutics are widely used in medicine . The aim of this study was the evaluation of the antiinflammatory potential of seven medical plant extracts using the ultraviolet- ( UV ) -erythema test . PATIENTS AND METHODS Randomized , placebo-controlled study on 40 healthy subjects . Test areas on the upper back were irradiated with the 1.5 fold UV-B minimal erythema dose ( MED ) . Formulations of Aloe vera , Chamomilla recutita , Hamamelis virginiana , Melissa officinalis , Mentha arvensis , Melaleuca alternifolia , Coriandrum sativum as well as 1 % hydrocortisone acetate and 0.1 % betamethasone valerate as positive controls and unguentum leniens as vehicle control were applied under occlusion on the irradiated areas and on non-irradiated area on the contralateral side . Photometric assessment of the erythema was performed before the application of the substances ( t0 ) , at 24 h ( t1 ) and at 48 h ( t2 ) . RESULTS Aloe vera , Chamomilla recutita , Melissa officinalis , Melaleuca alternifolia and Coriandrum sativum showed an antiinflammatory effect compared to UV-control and unguentum leniens . However , the results were only statistically significant for Aloe vera . All tested plant extracts were well tolerated . CONCLUSION Aloe vera possesses an antiinflammatory effect on UV-induced erythemas .
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Intervention_Pharmacological
seven plant extracts
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
seven medical plant extracts
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
1.5 fold UV-B minimal erythema dose
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Intervention_Pharmacological
Aloe vera
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Intervention_Pharmacological
Chamomilla recutita
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Intervention_Pharmacological
Hamamelis virginiana
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Intervention_Pharmacological
Melissa officinalis
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Intervention_Pharmacological
Mentha arvensis
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Intervention_Pharmacological
Melaleuca alternifolia
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Intervention_Pharmacological
Coriandrum sativum
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Intervention_Pharmacological
1 % hydrocortisone acetate
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Intervention_Pharmacological
0.1 % betamethasone valerate
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Intervention_Pharmacological
unguentum leniens
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Outcome_Other
tolerated
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Participant_Sample-size
40
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Participant_Condition
healthy