14000
document
T lymphocyte subsets and NK cell cytotoxicity in chronic hemodialysis patients . The effect of recombinant human erythropoietin ( rHu-EPO ) treatment . We investigated subpopulations of T lymphocytes , NK cell number and cytotoxic activity in 14 chronic uremic patients on regular hemodialysis treatment . We observed a significantly decreased absolute lymphocyte number and percentage of CD3 cells . Relative numbers of CD16 cells were significantly elevated , but NK cell cytotoxic activity was within a normal range . Nine patients with chronic renal anemia on maintenance hemodialysis were enrolled in rHu-EPO treatment trial . The treatment was continued till the hematocrit level reached 30 % . Each of the patients had corrected anemia and well-being . After 12 weeks of the treatment we observed in these patients decreases in CD3 , CD4 , CD8 and CD16 cell numbers and elevation of CD4/CD8 ratio . Cytotoxic activity of NK cells did not change significantly . Presented results indicate that chronic hemodialysis patients have significantly diminished lymphocyte number . rHu EPO treatment affects the T lymphocyte subsets inducing a deep decrease of CD8 and CD16 cell percentage leading to normalisation of the CD4/CD8 ratio .
14001
Intervention_Pharmacological
recombinant human erythropoietin ( rHu-EPO )
14002
Intervention_Control
regular hemodialysis treatment
14003
Intervention_Pharmacological
rHu-EPO
14004
Intervention_Pharmacological
rHu EPO
14005
Outcome_Physical
T lymphocytes
14006
Outcome_Physical
NK cell number
14007
Outcome_Other
cytotoxic activity
14008
Outcome_Physical
absolute lymphocyte number
14009
Outcome_Physical
percentage of CD3 cells
14010
Outcome_Physical
CD16 cells
14011
Outcome_Physical
NK cell cytotoxic activity
14012
Outcome_Physical
hematocrit level
14013
Outcome_Physical
anemia
14014
Outcome_Physical
CD3 , CD4 , CD8 and CD16 cell numbers
14015
Outcome_Physical
CD4/CD8 ratio
14016
Outcome_Physical
Cytotoxic activity of NK cells
14017
Outcome_Physical
lymphocyte number
14018
Outcome_Physical
CD8 and CD16 cell percentage
14019
Outcome_Physical
CD4/CD8 ratio
14020
Participant_Condition
hemodialysis
14021
Participant_Sample-size
14
14022
Participant_Condition
chronic uremic patients on regular hemodialysis
14023
Participant_Sample-size
Nine
14024
Participant_Condition
renal anemia