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document
p16 ( INK4a ) Expression does not predict the outcome of cervical intraepithelial neoplasia grade 2 . Spontaneous regression of cervical intraepithelial neoplasia grade 2 ( CIN2 ) lesions has been recognized since 1955 , but predictors of this are poorly understood . Among the predictive markers studied , p16 ( INK4a ) has been suggested to be of some value in monitoring the diagnosis of CIN2 . In this clinical trial , 90 Brazilian women , diagnosed to CIN2 and high-risk human papillomavirus infection , were randomized into two groups of equal size : 45 women whose lesions were excised and 45 women subjected to prospective follow-up at 3-month intervals at least for 1 year ( mean 6.8 months ) . p16 ( INK4a ) expression was analyzed in paraffin-embedded sections using immunohistochemical staining . Among the 45 women in the follow-up group , 42 % experienced spontaneous regression , 11 % showed persistence , 22 % progressed to CIN3 , and 20 % had partial regression to CIN1 or ASCUS ( atypical squamous cell undetermined signifiance ) . p16 ( INK4a ) expression was detected in 68.9 % of the patients . In univariate survival ( Cox ) analysis , no significant difference in regression was obtained between p16 ( INK4a ) -negative and -positive CIN2 lesions ( adjusted HR = 1.1 ; 95 % CI 0.6-2.0 ) . In conclusion , p16 ( INK4a ) expression could be useful in the diagnosis of CIN2 . However , it failed to predict the outcome of CIN2 . Because of its high spontaneous regression rate , follow-up could be considered as a management option of CIN2 in young and compliant women .
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Intervention_Physical
p16 ( INK4a ) Expression
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Intervention_Physical
p16 ( INK4a )
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Intervention_Surgical
lesions were excised
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Intervention_Other
prospective follow-up
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Intervention_Physical
p16 ( INK4a )
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Intervention_Physical
immunohistochemical staining
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Intervention_Physical
p16 ( INK4a )
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Intervention_Physical
p16 ( INK4a ) -negative
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Intervention_Other
and -positive
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Intervention_Other
p16 ( INK4a )
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Outcome_Physical
p16 ( INK4a ) Expression
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Outcome_Physical
p16 ( INK4a ) expression
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Outcome_Physical
p16 ( INK4a ) expression
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Outcome_Mortality
univariate survival ( Cox ) analysis
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Outcome_Physical
p16 ( INK4a ) expression
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Outcome_Physical
diagnosis of CIN2
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Outcome_Physical
CIN2
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Participant_Condition
90 Brazilian women , diagnosed to CIN2 and high-risk human papillomavirus infection , were randomized into two groups of equal size : 45 women whose lesions were excised and 45 women subjected to prospective follow-up at 3-month intervals at least for 1 year ( mean 6.8 months ) .
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Participant_Condition
45 women