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document
Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer : report from the Quality Assurance Working Party of the randomised phase III ROSEL study . BACKGROUND A phase III multi-centre randomised trial ( ROSEL ) has been initiated to establish the role of stereotactic radiotherapy in patients with operable stage IA lung cancer . Due to rapid changes in radiotherapy technology and evolving techniques for image-guided delivery , guidelines had to be developed in order to ensure uniformity in implementation of stereotactic radiotherapy in this multi-centre study . METHODS/DESIGN A Quality Assurance Working Party was formed by radiation oncologists and clinical physicists from both academic as well as non-academic hospitals that had already implemented stereotactic radiotherapy for lung cancer . A literature survey was conducted and consensus meetings were held in which both the knowledge from the literature and clinical experience were pooled . In addition , a planning study was performed in 26 stage I patients , of which 22 were stage 1A , in order to develop and evaluate the planning guidelines . Plans were optimised according to parameters adopted from RTOG trials using both an algorithm with a simple homogeneity correction ( Type A ) and a more advanced algorithm ( Type B ) . Dose conformity requirements were then formulated based on these results . CONCLUSION Based on current literature and expert experience , guidelines were formulated for this phase III study of stereotactic radiotherapy versus surgery . These guidelines can serve to facilitate the design of future multi-centre clinical trials of stereotactic radiotherapy in other patient groups and aid a more uniform implementation of this technique outside clinical trials .
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Intervention_Physical
stereotactic radiotherapy
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Intervention_Physical
stereotactic radiotherapy
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Intervention_Physical
stereotactic radiotherapy
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Intervention_Physical
stereotactic radiotherapy
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Intervention_Physical
stereotactic radiotherapy
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Outcome_Other
guidelines were formulated for this phase III study of stereotactic radiotherapy versus surgery
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Participant_Condition
peripheral stage IA non-small cell lung cancer :