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document
Design and implementation of the TRACIA : intracoronary autologous transplant of bone marrow-derived stem cells for acute ST elevation myocardial infarction . OBJECTIVE To describe the design of a protocol of intracoronary autologous transplant of bone marrow-derived stem cells for acute ST-elevation myocardial infarction ( STEMI ) and to report the safety of the procedure in the first patients included . METHODS The TRACIA study was implemented following predetermined inclusion and exclusion criteria . The protocol includes procedures such as randomization , bone marrow retrieval , stem cells processing , intracoronary infusion of stem cells in the infarct-related artery , preand- post MRI , pre-and-post SPECT with radioisotope ventriculography , and clinical follow-up at 6 months . RESULTS Eight patients with a diagnosis of acute STEMI and duration of symptoms of ? 24 hours that were perfused successfully through primary percutaneous coronary intervention ( PPCI ) with a LVEF of ? 45 % were assigned randomly to two groups ( n = 4 each ) . One group treated with stem cells and the other corresponded to the control group . Neither death , re-infarction , no need for revascularization or thrombosis of the stent were observed at follow-up . CONCLUSIONS The initial experience at the Instituto Nacional de Cardiología Ignacio Chávez in the treatment of acute STEMI by means of autologous transplantation of bone marrow-derived stem cells is encouraging . Implementation was possible in the first eight patients with no complications .
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Intervention_Pharmacological
intracoronary autologous transplant of bone marrow-derived stem cells
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Intervention_Pharmacological
stem cells
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Intervention_Control
control group .
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Outcome_Physical
acute STEMI and duration of symptoms
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Outcome_Mortality
death
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Outcome_Physical
re-infarction , no need for revascularization or thrombosis of the stent
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Participant_Condition
acute ST elevation myocardial infarction
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Participant_Condition
acute ST-elevation myocardial infarction ( STEMI )
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Participant_Sample-size
Eight patients
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Participant_Condition
diagnosis of acute STEMI and duration of symptoms of ? 24 hours that were perfused successfully through primary percutaneous coronary intervention ( PPCI ) with a LVEF of ? 45
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Participant_Condition
the Instituto Nacional de Cardiología Ignacio Chávez
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Participant_Condition
acute STEMI