80096
document
The influence of amiloride on the therapeutic and metabolic effects of carbenoxolone in patients with gastric ulcer . A double-blind controlled trial . Patients with benign gastric ulcer were treated for four weeks with carbenoxolone sodium as Biogastrone tablets 100 mg three times a day , and if the ulcers were not healed at 4 weeks treatment was continued for a further 4 weeks . Fifty two patients entered the trial , and 12 were withdrawn . In 17 patients who were randomly allotted double-blind additional dummy tablets 16 of their ulcer healed completely endoscopically , whereas of the 23 patients given additional amiloride 5 mg three times a day only 14 ulcers healed , a significant reduction in ulcer healing . The clinical ( weight gain and oedema ) and metabolic ( hypertension , hypokalaemia and hypernatraemia ) side-effects were reduced by the active amiloride therapy , but serum carbenoxolone levels were not affected . Thus the potassium-retaining diuretic amiloride , like the aldosterone antagonist spironolactone , markedly reduces both the ulcer-healing and the metabolic side-effects of carbenoxolone sodium , and should not be used together with it in the treatment of peptic ulcer .
80097
Intervention_Pharmacological
amiloride
80098
Intervention_Pharmacological
carbenoxolone
80099
Intervention_Pharmacological
carbenoxolone sodium as Biogastrone tablets 100 mg three times a day
80100
Intervention_Control
dummy tablets
80101
Intervention_Pharmacological
amiloride
80102
Intervention_Pharmacological
amiloride
80103
Intervention_Pharmacological
carbenoxolone
80104
Intervention_Pharmacological
amiloride
80105
Intervention_Pharmacological
spironolactone
80106
Outcome_Physical
weight gain
80107
Outcome_Physical
oedema
80108
Outcome_Physical
hypertension , hypokalaemia and hypernatraemia
80109
Outcome_Physical
serum carbenoxolone levels
80110
Outcome_Physical
ulcer-healing
80111
Outcome_Adverse-effects
metabolic side-effects
80112
Participant_Condition
patients with gastric ulcer .
80113
Participant_Condition
Patients with benign gastric ulcer
80114
Participant_Condition
Fifty two patients entered the trial , and 12 were withdrawn .
80115
Participant_Condition
peptic ulcer .