48748
document
Effect of weight loss on inflammation in patients with mild obstructive sleep apnea . BACKGROUND AND AIMS Inflammation may be one mediating mechanism for cardiovascular diseases in obstructive sleep apnea ( OSA ) . However , little is known about subclinical inflammation or the effect of lifestyle intervention on inflammation in early stages of OSA . The aim of this substudy of an existing randomized controlled trial , with post hoc analyses , was to determine the impact of lifestyle changes aimed at weight reduction on inflammatory biomarkers in overweight patients with mild OSA . METHODS AND RESULTS Patients were randomized to supervised intensive lifestyle intervention group ( N=28 ) or to control group ( N=31 ) , which received routine lifestyle advices . Circulating concentrations of pro- and anti-inflammatory mediators were measured before and after the 1-year intervention . The concentrations of two pro-inflammatory mediators , high-sensitivity C-reactive protein ( hsCRP ) and interleukin ( IL ) -6 , decreased significantly in both groups . Although the changes in inflammatory biomarkers favored the supervised lifestyle intervention , the only significant reduction observed between the groups was for the anti-inflammatory IL-1 receptor antagonist ( IL-1RA ) . The change in hsCRP was associated with apnea-hypopnea index , and improving night-time oxygen saturation was related to tumor necrosis factor alpha . IL-1RA and IL-6 were associated with insulin metabolism . CONCLUSION Weight loss resulted in reductions in concentrations of some pro- and anti-inflammatory mediators in overweight patients with mild OSA , overall favoring the supervised lifestyle intervention . These findings suggest that more intensive treatment of obesity in OSA patients might be well-justified .
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Intervention_Educational
supervised intensive lifestyle intervention group
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Intervention_Control
control group
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Intervention_Educational
routine lifestyle advices
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Intervention_Educational
lifestyle intervention
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Intervention_Educational
lifestyle intervention
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Outcome_Other
high-sensitivity C-reactive protein ( hsCRP ) and interleukin ( IL ) -6 , decreased
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Outcome_Physical
inflammatory biomarkers favored
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Outcome_Physical
change in hsCRP
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Outcome_Physical
apnea-hypopnea index
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Outcome_Physical
improving night-time oxygen saturation
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Outcome_Physical
Weight loss
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Participant_Condition
patients with mild obstructive sleep apnea .
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Participant_Condition
cardiovascular diseases
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Participant_Condition
obstructive sleep apnea ( OSA )
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Participant_Condition
overweight
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Participant_Condition
mild OSA .
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Participant_Sample-size
N=28
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Participant_Sample-size
N=31
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Participant_Condition
overweight
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Participant_Condition
mild OSA
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Participant_Condition
OSA