86209
document
A double-blind comparison of clomipramine , desipramine , and placebo in the treatment of autistic disorder . OBJECTIVE To determine whether clomipramine hydrochloride , a serotonin reuptake blocker with unique anti-obsessional properties , is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent , desipramine hydrochloride . DESIGN Following a 2-week , single-blind placebo washout phase , 12 autistic subjects completed a 10-week , double-blind , crossover comparison of clomipramine and placebo , and 12 different subjects completed a similar comparison of clomipramine and desipramine . SETTING Outpatient clinic . PATIENTS A referral sample of 30 male and female autistic patients were enrolled , and 24 completed the study . MEASURES Key outcome measures were the Autism Relevant Subscale of the Children 's Psychiatric Rating Scale , the Modified Comprehensive Psychopathological Rating Scale-Obsessive-Compulsive Disorder Subscale , and the Clinical Global Impressions Scale . RESULTS Clomipramine was superior to both placebo and desipramine on ratings of autistic symptoms ( including stereotypies ) , anger , and compulsive , ritualized behaviors ( P < .05 ) , with no differences between desipramine and placebo . Clomipramine was equal to desipramine and both tricyclic agents were superior to placebo for amelioration of hyperactivity . CONCLUSION Biological links between compulsions and stereotyped , repetitive behaviors in autistic disorder should be explored .
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Intervention_Pharmacological
clomipramine
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Intervention_Pharmacological
desipramine
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Intervention_Control
placebo
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Intervention_Pharmacological
clomipramine hydrochloride
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Intervention_Control
placebo
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Intervention_Pharmacological
noradrenergic tricyclic antidepressant agent
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Intervention_Pharmacological
desipramine hydrochloride
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Intervention_Control
placebo
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Intervention_Pharmacological
clomipramine
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Intervention_Control
placebo
86220
Intervention_Pharmacological
clomipramine
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Intervention_Pharmacological
desipramine
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Intervention_Pharmacological
Clomipramine
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Intervention_Pharmacological
desipramine
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Intervention_Control
placebo
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Intervention_Pharmacological
Clomipramine
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Intervention_Pharmacological
desipramine
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Outcome_Mental
Autism Relevant Subscale of the Children 's Psychiatric Rating Scale
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Outcome_Mental
the Modified Comprehensive Psychopathological Rating Scale-Obsessive-Compulsive Disorder Subscale
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Outcome_Mental
Clinical Global Impressions Scale
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Outcome_Mental
autistic symptoms ( including stereotypies ) , anger , and compulsive , ritualized behaviors
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Outcome_Mental
hyperactivity
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Participant_Condition
autistic disorder .
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Participant_Condition
12 autistic subjects
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Participant_Condition
12 different subjects