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document
Endurance physical activity , diet and fibrinolysis . The impact of long-term , heavy exercise on recently established cardiovascular/thromboembolic risk factors of the fibrinolytic system , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI-1 ) in relation to food composition was studied . Twenty healthy men , aged 18-55 years participated in a 14-day skiing tour through the Swedish mountains , carrying a pack load of 30 kg , and spending each night in self-dug igloos ( ambient temp -10 degrees to -25 degrees C ) , and were randomized to 2 food regimens having 30 or 40 energy percent of fat . Individual records were kept of all consumed food . Citrated plasma was obtained before and after 1 and 2 weeks of exercise : tPA release was assessed by a 10 min venous occlusion ( VO ) test . At baseline , daily dietary fiber intake correlated negatively with PAI-1 activity . Already after the first week of the skiing tour there were significant drops in PAI-1 activities , cholesterol and triglycerides . The tPA mass concentrations also dropped , both before and after VO , but tPA activities were unchanged , as were von Willebrand factor ( vWF ) levels . These changes were related mainly to the expenditure of energy , calculated from the food consumption , and appeared to be mediated through changed insulin sensitivity and decreased body fat mass . The energy percent of fat in the food had no differential impact . The effects receded a few weeks after cessation of the endurance exercise . Thus , endurance physical activity improves the fibrinolytic risk factor profile by reducing PAI-1 while leaving tPA activity unaffected , independently of food composition . A low dietary fiber intake appears to be associated with higher PAI-1 activities at baseline .
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Intervention_Physical
Endurance physical activity ,
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Intervention_Other
diet
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Intervention_Physical
long-term , heavy exercise
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Intervention_Physical
14-day skiing tour through the Swedish mountains , carrying a pack load of 30 kg , and spending each night in self-dug igloos ( ambient temp -10 degrees to -25 degrees C )
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Intervention_Other
2 food regimens having 30 or 40 energy percent of fat
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Intervention_Educational
Individual records were kept of all consumed food
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Intervention_Physical
Citrated plasma was obtained before and after 1 and 2 weeks of exercise : tPA release was assessed by a 10 min venous occlusion ( VO ) test
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Intervention_Educational
daily dietary fiber intake
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Intervention_Physical
endurance physical activity
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Outcome_Physical
Citrated plasma
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Outcome_Physical
tPA release
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Outcome_Mental
daily dietary fiber intake
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Outcome_Physical
PAI-1 activities , cholesterol and triglycerides
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Outcome_Physical
tPA mass concentrations
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Outcome_Physical
tPA activities
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Outcome_Physical
von Willebrand factor ( vWF ) levels
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Outcome_Physical
tPA
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Outcome_Physical
PAI-1 activities
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Participant_Sample-size
Twenty
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Participant_Age
18-55 years