76343
document
Effects of nifedipine on gastric acid secretion and gastrin release in man . As calcium is important in the regulation of gastric acid secretion and gastrin release , we have examined the effect of the calcium antagonist nifedipine on these processes in man . Nifedipine 30 mg orally inhibited basal acid output by 37 % ( p less than 0.025 ) and that stimulated by low infusion rates of pentagastrin -- that is , 0.031 and 0.062 microgram/kg/h by 44 % ( p = 0.05 ) and 39 % ( p less than 0.02 ) respectively . On increasing the pentagastrin infusion rate the inhibition was surmounted suggesting it was competitive in type . Nifedipine did not affect basal or Oxo meal stimulated gastrin concentrations in normal volunteers nor did it affect resting serum gastrin or calcium stimulated increase in gastrin in a single patient with Zollinger-Ellison syndrome . These findings are consistent with the transmembrane flux of calcium ions being involved in basal and pentagastrin stimulated acid secretion in man .
76344
Intervention_Pharmacological
nifedipine
76345
Intervention_Pharmacological
nifedipine
76346
Intervention_Pharmacological
Nifedipine
76347
Intervention_Pharmacological
pentagastrin
76348
Intervention_Pharmacological
pentagastrin
76349
Intervention_Pharmacological
Nifedipine
76350
Outcome_Physical
gastric acid secretion
76351
Outcome_Physical
gastrin release
76352
Outcome_Physical
basal or Oxo meal stimulated gastrin concentrations
76353
Outcome_Physical
resting serum gastrin
76354
Outcome_Physical
calcium stimulated increase in gastrin
76355
Participant_Condition
gastric acid secretion
76356
Participant_Condition
gastrin release
76357
Participant_Sex
man
76358
Participant_Condition
Zollinger-Ellison syndrome
76359
Participant_Condition
pentagastrin stimulated acid secretion