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document
[ Efficacy of immunomodulating treatment in patients with different degrees of immunosuppression ] . Immunodepression is a common condition in patients undergoing elective operations and it constitutes a high risk for the onset of postoperative infective complications . The use of immunomodulatory drugs has proved useful in the prophylaxis of these complications , although the precise indications for each drug have not yet been clearly codified . The present study aimed to assess the effects of thymostimulin in patients with different degrees of immunodepression , by evaluating both the incidence of postoperative infections and the changes induced in various immunological parameters . The results obtained indicated that those subjects with the highest degree of immunodepression ( hypo-anergic ) benefited most from drug therapy in comparison to those with a lesser degree of immunodepression ( relatively hypo-ergic ) . The advantages were evident in hypo-anergic subjects both with regard to the frequency of early postoperative infections , and with regard to immunological parameters . On the other hand , in relatively hypo-ergic subjects , benefits were limited to the improvement of some immunological parameters . In our opinion , the use of thymostimulin is of particular use only in those subjects with marked immunodepression since the incidence of post-operative sepsis is highest in this group .
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Intervention_Pharmacological
immunomodulatory drugs
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Intervention_Pharmacological
thymostimulin
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Intervention_Pharmacological
drug therapy
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Intervention_Pharmacological
thymostimulin
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Outcome_Adverse-effects
incidence of postoperative infections
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Outcome_Physical
immunological parameters
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Outcome_Adverse-effects
frequency of early postoperative infections
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Outcome_Physical
immunological parameters
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Outcome_Physical
immunological parameters
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Outcome_Physical
post-operative sepsis
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Participant_Condition
immunosuppression
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Participant_Condition
immunodepression