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document
Netilmicin versus tobramycin in multi-centre studies . In two prospective , randomized studies conducted in West Germany and involving 80 patients , netilmicin-ticarcillin was compared to tobramycin-ticarcillin in the treatment of serious systemic infections . Both regimens were essentially identical with respect to the clinical and bacteriological results they produced . The netilmicin group developed significantly less nephrotoxicity than the tobramycin group ( 0 % versus 15 % , P = 0.03 ) . Ototoxicity also occurred less frequently in the netilmicin-treated patients ( 3 % versus 10 % , P = 0.4 ) . In a large collaborative study involving 15 centres , 254 patients were enrolled . Clinical and bacteriological responses were excellent , with netilmicin and tobramycin equally effective , but the incidences of nephrotoxicity and ototoxicity were lower in patients treated with netilmicin than those receiving tobramycin .
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Intervention_Pharmacological
Netilmicin versus tobramycin
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Intervention_Pharmacological
netilmicin-ticarcillin
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Intervention_Pharmacological
tobramycin-ticarcillin
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Outcome_Physical
nephrotoxicity
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Outcome_Physical
Ototoxicity
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Outcome_Physical
Clinical and bacteriological responses
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Outcome_Other
effective
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Outcome_Physical
nephrotoxicity
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Outcome_Physical
ototoxicity
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Participant_Sample-size
80
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Participant_Condition
serious systemic infections
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Participant_Sample-size
254