6584
document
The clinical and biochemical effects of propofol infusion with and without EDTA for maintenance anesthesia in healthy children undergoing ambulatory surgery . UNLABELLED We conducted this randomized , double-blinded , comparative , parallel-group study to determine whether adding EDTA to propofol would affect the clinical profile , calcium and magnesium homeostasis , or renal function in healthy children . After the induction of anesthesia with halothane , 69 ambulatory surgical patients ( 1 mo to < 17 yr old ) , received propofol without EDTA ( n = 33 ) or propofol with EDTA ( n = 36 ) . Blood samples were obtained for the measurement of ionized calcium , ionized magnesium , and laboratory indicators of renal function . Hemodynamic measurements , recovery , and adverse events were recorded . Propofol with EDTA produced no significant effects on clinical efficacy or renal function . Propofol and propofol EDTA produced a statistically significant decrease from baseline in serum concentrations of ionized calcium and magnesium during infusion ( P < 0.05 ) , but with no apparent clinical effect . Hemodynamic measurements generally remained stable and were similar for both groups . Statistically significant changes in systolic blood pressure , mean arterial pressure , and heart rate were not considered clinically significant . Adverse events were mild or moderate . The addition of EDTA does not alter the clinical profile of propofol in pediatric ambulatory surgical patients . With or without EDTA , propofol is associated with a decrease in ionized calcium with no apparent clinical effect . IMPLICATIONS The addition of EDTA does not alter the clinical profile of propofol in pediatric ambulatory surgical patients . With or without EDTA , propofol is associated with a decrease in ionized calcium with no apparent clinical effect .
6585
Intervention_Pharmacological
propofol
6586
Intervention_Pharmacological
with and without EDTA
6587
Intervention_Pharmacological
EDTA to propofol
6588
Intervention_Pharmacological
induction of anesthesia with halothane
6589
Intervention_Pharmacological
propofol without EDTA
6590
Intervention_Pharmacological
propofol with EDTA
6591
Intervention_Pharmacological
Propofol with EDTA
6592
Intervention_Pharmacological
Propofol
6593
Intervention_Pharmacological
propofol EDTA
6594
Intervention_Pharmacological
EDTA
6595
Intervention_Pharmacological
EDTA
6596
Intervention_Pharmacological
propofol
6597
Outcome_Mental
Blood samples
6598
Outcome_Mental
measurement of ionized calcium , ionized magnesium , and laboratory indicators of renal function .
6599
Outcome_Physical
Hemodynamic measurements , recovery
6600
Outcome_Physical
adverse events
6601
Outcome_Physical
clinical efficacy or renal function .
6602
Outcome_Physical
decrease from baseline in serum concentrations of ionized calcium and magnesium during infusion
6603
Outcome_Physical
Hemodynamic measurements
6604
Outcome_Other
systolic blood pressure , mean arterial pressure , and heart rate
6605
Outcome_Mental
ionized calcium
6606
Outcome_Physical
ionized calcium
6607
Participant_Age
children
6608
Participant_Condition
ambulatory surgery
6609
Participant_Age
children
6610
Participant_Sample-size
69
6611
Participant_Condition
ambulatory surgical
6612
Participant_Age
1 mo to < 17 yr old
6613
Participant_Condition
ambulatory surgical
6614
Participant_Condition
ambulatory surgical