73405
document
The Effects of Valsartan and Amlodipine on the Levels of Irisin , Adropin , and Perilipin . BACKGROUND Hypertension and obesity are two major threats for public health . Up to the present , antihypertensive medications have been used to lower blood pressure , which seem to provide a better life with lower morbidity and mortality rates . Their effect on etiopathogenesis of hypertension is now an area of developing research . The association between hypertension and obesity also suggests the link between antihypertensive agents and energy hemostasis . We aimed to investigate the effects of antihypertensive treatment on the irisin , adropin , and perilipin levels in patients with essential hypertension and to compare them with healthy volunteers in terms of their effect on energy hemostasis . METHODS In total , 85 newly diagnosed patients with untreated essential hypertension were admitted to the outpatient clinic . Patients were randomized to one of the following treatment protocols : amlodipine or valsartan for a 12 week period . 42 patients were randomized into the valsartan group and 43 patients into the amlodipine group . Serum perilipin , irisin , and adropin levels were measured before and after drug treatment by ELISA kits . RESULTS We discovered that the hypertensive patients have lower levels of perilipin and higher levels of adropin compared with the control group . Both amlodipine and valsartan increased the levels of perilipin , irisin , and adropin after 12 weeks of treatment . CONCLUSIONS In conclusion , in regulating energy balance , perilipin , irisin , and adropin , could be of pathogenic importance in obesity-induced hypertension . Hence , ongoing trials need to elucidate this mechanism .
73406
Intervention_Pharmacological
Valsartan
73407
Intervention_Pharmacological
Amlodipine
73408
Intervention_Pharmacological
Irisin
73409
Intervention_Pharmacological
Adropin
73410
Intervention_Pharmacological
Perilipin
73411
Intervention_Pharmacological
amlodipine
73412
Intervention_Pharmacological
valsartan
73413
Intervention_Pharmacological
valsartan
73414
Intervention_Pharmacological
amlodipine
73415
Intervention_Pharmacological
ELISA kits
73416
Intervention_Pharmacological
amlodipine
73417
Intervention_Pharmacological
valsartan
73418
Outcome_Physical
Serum perilipin , irisin , and adropin levels
73419
Outcome_Physical
levels of perilipin
73420
Outcome_Physical
levels of adropin
73421
Outcome_Physical
levels of perilipin , irisin , and adropin