24692
document
Biochemical and functional effects of creatine phosphate in cardioplegic solution during aortic valve surgery -- a clinical study . During myocardial ischemia there is a drop in high-energy phosphates in the myocardium . Cold potassium cardioplegia decreases but does not altogether prevent this reduction . Supplementation of cardioplegic solutions with the high-energy compound creatine phosphate ( 10 mmol/L ) compared to plain cardioplegic solutions was investigated in this study . Thirty patients scheduled for aortic valve replacement were included . The patients were randomized to group I ( creatine phosphate ) or group II ( control ) . Postoperative hemodynamic evaluation revealed no significant differences between the groups . However , group I exhibited a tendency toward a better stroke-work index ( 135 +/- 18 % vs. 102 +/- 5 % recovery 15 minutes after bypass and 145 +/- 16 % vs. 119 +/- 11 % recovery 105 min after bypass ) . There were fewer patients in group I ( 5/15 ) needing inotropic support compared to group II ( 9/14 ) . The myocardial content of ATP and creatine phosphate showed no significant differences during ischemia and reperfusion . It is concluded that the myocardial protection during ischemia was sufficient to prevent significant reductions of myocardial ATP and creatine phosphate irrespective of supplementation with CP .
24693
Intervention_Pharmacological
creatine phosphate
24694
Intervention_Pharmacological
creatine phosphate
24695
Intervention_Control
plain cardioplegic solutions
24696
Intervention_Pharmacological
creatine phosphate
24697
Intervention_Control
control
24698
Intervention_Pharmacological
creatine phosphate
24699
Outcome_Physical
drop in high-energy phosphates
24700
Outcome_Physical
hemodynamic evaluation
24701
Outcome_Physical
stroke-work index
24702
Outcome_Physical
needing inotropic support
24703
Outcome_Physical
myocardial content of ATP and creatine phosphate
24704
Outcome_Physical
myocardial ATP and creatine phosphate
24705
Participant_Condition
aortic valve surgery -- a