85458
document
Video rating analysis of effect of maprotiline in patients with dementia and depression . In patients with dementia and mild depression ( DSM-III-R 290.21 ) , the effect of low doses of the antidepressant maprotiline ( up to 75 mg/d ) was examined . The main parameter was a video rating of global impression . The Mini-Mental State Examination ( MMS ) and the Geriatric Depression Scale ( GDS ) were applied to evaluate the effect of maprotiline on cognitive and depressive symptoms . The double-blind , placebo-controlled trial was of eight weeks ' duration and included 127 patients , randomized in two groups . The antidepressant effect of maprotiline was reflected in the GDS . There was , however , no indication of an effect of maprotiline on cognitive performance . The global impression , evaluated by video rating , gave no indication as to a beneficial effect of the treatment . - The video analysis showed a significant interrater reliability . The discrepancy between the results of the video rating and the GDS is discussed . - The results confirm similar findings of other authors ; i.e. , that a sedating antidepressant with some anticholinergic effects can not be expected to improve cognitive functions despite its antidepressant effect . The main interest of this study , however , lies in its methodology ( video analysis ) .
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Intervention_Pharmacological
maprotiline
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Intervention_Educational
Mini-Mental State Examination ( MMS )
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Intervention_Educational
Geriatric Depression Scale ( GDS )
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
maprotiline
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Outcome_Mental
Mini-Mental State Examination
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Outcome_Mental
Geriatric Depression Scale
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Outcome_Mental
cognitive performance
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Outcome_Other
reliability
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Outcome_Mental
.
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Outcome_Mental
cognitive functions
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Participant_Condition
patients with dementia and depression .
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Participant_Condition
patients with dementia and mild depression ( DSM-III-R 290.21 )