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document
No association between dinucleotide repeat polymorphism in intron 1 of the epidermal growth factor receptor gene EGFR and risk of lung cancer . The tyrosine kinase receptor EGFR pathway is one of the oncogenic signaling cascades involved in lung cancer , mediating the epidermal growth factor receptor gene EGFR . First-intron polymorphisms with greater numbers of CA dinucleotide repeats tend to downregulate EGFR expression , which suggests that this polymorphism may modulate susceptibility to lung cancer . The present hospital-based case-control study evaluated the possible association of CA repeat polymorphism in the EGFR gene with risk of lung cancer in a Korean population . A bimodal pattern appeared , with a frequency of 57.1 % for 20 CA repeats and 18.6 % for 16 CA repeats . There was , however , no significant difference in distribution of allele genotypes between all lung cancer cases and the controls , nor among histological types for the cases .
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Intervention_Physical
First-intron polymorphisms
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Intervention_Physical
polymorphism
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Intervention_Physical
hospital-based case-control study evaluated the possible association of CA repeat
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Intervention_Other
polymorphism in the EGFR gene
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Outcome_Physical
EGFR gene
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Participant_Condition
risk of lung cancer .
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Participant_Condition
susceptibility to lung cancer .
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Participant_Condition
CA repeat polymorphism in the EGFR gene with risk of lung cancer in a Korean population .