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document
[ New approaches to evaluation of nonspecific inhalation provocation ( dose-response relationship ) in the comparative evaluation of bronchial hyperreactivity within the scope of clinical trials ] . For the performance of clinical drug trials in the therapy for bronchial hyperresponsiveness , unspecific inhalatory provocation tests are generally employed to judge therapeutic success . In particular , the parameter-specific provocation doses are considered to be the main target values . However , it must be considered that these provocation doses are not equally calculable for every patient in the same way and at any examination time . This leads to the fact that the number of evaluable case studies is often appreciably lower than the number of test participants and that a meaningful therapy group comparison may even not be possible under certain circumstances . An evaluation model is presented here in order to fully exploit the obtained data ; in this the percentile changes of the function parameters ( estimated by linear regression ) at a defined dose of the provocation substance are analyzed . In analogy , a survival time model and , as a supplement , a best case/worst case analysis are performed for further statistical evaluation . With the present procedure , an evaluation with inclusion of all test participants is possible . In contrast to the previously used evaluation procedures , this allows a reliable statistical confirmation of the results of clinical tests in the therapy for bronchial hyperresponsiveness .
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Intervention_Pharmacological
nonspecific inhalation provocation
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Outcome_Mortality
survival time model
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Participant_Condition
bronchial hyperreactivity
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Participant_Condition
bronchial hyperresponsiveness
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Participant_Condition
bronchial hyperresponsiveness .