8041
document
A double-blind , placebo-controlled crossover study investigating the effect of porcine secretin in children with autism . OBJECTIVES A recent patient series reported the incidental findings of improved social and language skills in 3 children with autistic spectrum disorders after the administration of secretin , a peptide hormone . However , a subsequent study did not find evidence for a drug effect . Parents are seeking treatment with secretin despite the absence of empirical investigations demonstrating amelioration in autism symptomology . In order to more precisely measure the effects of secretin , this study investigated the effect of a single intravenous dose of porcine secretin on 12 autistic children through a randomized , double-blind , placebo-controlled , crossover study . Children were assessed on objective language and on social , neuropsychological , and gastrointestinal measures to evaluate drug effects . The study was conducted over a 16-week trial . The results indicated that significant differences were not observed on the majority of the dependent variables . Statistically significant differences were observed on measures of positive affect and activity level following secretin infusion . In general , the autistic children did not demonstrate the improvements described in the initial retrospective report .
8042
Intervention_Control
placebo-controlled
8043
Intervention_Pharmacological
porcine secretin
8044
Intervention_Pharmacological
secretin
8045
Intervention_Pharmacological
secretin
8046
Intervention_Pharmacological
secretin
8047
Intervention_Pharmacological
intravenous dose of porcine secretin
8048
Intervention_Control
placebo-controlled
8049
Intervention_Pharmacological
secretin
8050
Outcome_Mental
objective language and on social , neuropsychological , and
8051
Outcome_Physical
gastrointestinal measures
8052
Outcome_Mental
measures of positive affect and activity level
8053
Participant_Age
children
8054
Participant_Condition
autism
8055
Participant_Age
children
8056
Participant_Condition
autistic spectrum disorders
8057
Participant_Sample-size
12
8058
Participant_Age
children
8059
Participant_Age
children