91151
document
Postoperative analgesia by D-myo-inositol-1,2,6-trisphosphate in patients undergoing cholecystectomy . UNLABELLED D-myo-inositol-1,2,6-trisphosphate ( 1,2,6-IP3 ) possesses antiinflammatory properties , such as reduced eicosanoid synthesis and inhibition of inflammation-induced edema . These properties suggest possible analgesic effects . The analgesic effect of 1,2,6-IP3 was evaluated in a double-blind , randomized study in 24 patients undergoing cholecystectomy . Ten patients received 1,2,6-IP3 as an intravenous ( i.v . ) bolus dose of 240 mg , followed by a continuous i.v . infusion at 90 mg/h for 24 h. The placebo group ( n = 14 ) received corresponding volumes of isotonic saline . Postoperative pain ( visual analog pain scale ; VAS ) and opiate analgesic requirements ( ketobemidon ) were evaluated during five postoperative days . Results showed significantly reduced pain during the first five postoperative days in patients treated with 1,2,6-IP3 , as measured by using a VAS ( P < 0.05 ) . The requirements of opioid analgesics were significantly reduced during the first three postoperative days ( P < 0.05 ) . No drug-related side effects were observed . Results of the present study demonstrate a potent and long-lasting analgesic effect of 1,2,6-IP3 , possibly related to its antiinflammatory properties . IMPLICATIONS A new antiinflammatory drug under investigation , inositol-1,2,6-trisphosphate , was evaluated as a possible analgesic in a pilot study during the postoperative period in cholecystectomized patients . Results showed significantly lower pain assessment and opioid consumption , which should encourage further studies .
91152
Intervention_Pharmacological
D-myo-inositol-1,2,6-trisphosphate
91153
Intervention_Pharmacological
D-myo-inositol-1,2,6-trisphosphate ( 1,2,6-IP3 )
91154
Intervention_Surgical
cholecystectomy
91155
Intervention_Pharmacological
1,2,6-IP3
91156
Intervention_Control
placebo
91157
Intervention_Pharmacological
isotonic saline
91158
Intervention_Pharmacological
ketobemidon
91159
Intervention_Pharmacological
inositol-1,2,6-trisphosphate
91160
Outcome_Physical
analgesic effects
91161
Outcome_Physical
analgesic effect
91162
Outcome_Pain
Postoperative pain
91163
Outcome_Pain
visual analog pain scale ; VAS
91164
Outcome_Pain
opiate analgesic requirements
91165
Outcome_Physical
(
91166
Outcome_Pain
ketobemidon
91167
Outcome_Physical
)
91168
Outcome_Pain
pain
91169
Outcome_Pain
VAS
91170
Outcome_Physical
requirements of
91171
Outcome_Pain
opioid analgesics
91172
Outcome_Adverse-effects
drug-related side effects
91173
Outcome_Other
potent and long-lasting analgesic effect
91174
Outcome_Pain
lower pain assessment
91175
Outcome_Pain
opioid consumption
91176
Participant_Condition
patients undergoing cholecystectomy
91177
Participant_Sample-size
24