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document
Pregabalin versus naltrexone in alcohol dependence : a randomised , double-blind , comparison trial . Pregabalin ( PRE ) acts as a presynaptic inhibitor of the release of excessive levels of excitatory neurotransmitters by selectively binding to the alpha ( 2 ) -delta subunit of voltage-gated calcium channels . In this randomised , double-blind comparison trial with naltrexone ( NAL ) , we aimed to investigate the efficacy of PRE on alcohol drinking indices . Craving reduction and improvement of psychiatric symptoms were the secondary endpoints . Seventy-one alcohol-dependent subjects were detoxified and subsequently randomised into two groups , receiving 50 mg of NAL or 150-450 mg of PRE . Craving ( VAS ; OCDS ) , withdrawal ( CIWA-Ar ) and psychiatric symptoms ( SCL-90-R ) rating scales were applied . Alcohol drinking indices and craving scores were not significantly different between groups . Compared with NAL , PRE resulted in greater improvement of specific symptoms in the areas of anxiety , hostility and psychoticism , and survival function ( duration of abstinence from alcohol ) . PRE also resulted in better outcome in patients reporting a comorbid psychiatric disorder . Results from this study globally place PRE within the same range of efficacy as that of NAL . The mechanism involved in the efficacy of PRE in relapse prevention could be less related to alcohol craving and more associated with the treatment of the comorbid psychiatric symptomatology .
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Intervention_Pharmacological
Pregabalin
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Intervention_Pharmacological
naltrexone
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Intervention_Pharmacological
Pregabalin ( PRE )
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Intervention_Pharmacological
naltrexone ( NAL )
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Intervention_Pharmacological
receiving 50 mg of NAL or 150-450 mg of PRE .
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Intervention_Pharmacological
NAL , PRE
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Intervention_Pharmacological
NAL .
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Intervention_Pharmacological
PRE
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Outcome_Mental
alcohol drinking indices
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Outcome_Mental
Craving reduction
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Outcome_Mental
improvement of psychiatric symptoms
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Outcome_Mental
Craving ( VAS ; OCDS )
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Outcome_Other
withdrawal ( CIWA-Ar )
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Outcome_Mental
psychiatric symptoms ( SCL-90-R ) rating scales
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Outcome_Mental
Alcohol drinking indices
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Outcome_Mental
craving scores
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Outcome_Mental
anxiety
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Outcome_Mental
hostility
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Outcome_Mental
psychoticism
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Outcome_Mortality
survival function
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Outcome_Mental
duration of abstinence from alcohol
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Outcome_Mental
alcohol craving
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Participant_Condition
alcohol dependence
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Participant_Sample-size
Seventy-one
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Participant_Condition
comorbid psychiatric disorder