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document
Do heavier women benefit from a higher dose of leuprolide acetate for suppression of serum estradiol ? OBJECTIVE To determine if heavier women benefit from a higher dose of the gonadotropin-releasing hormone analogue leuprolide acetate ( LA ) depot in terms of suppression of serum estradiol . METHODS This was a retrospective analysis of the effect of LA depot 3.75 mg and 7.5 mg on serum estradiol from a multicenter , double-blind , parallel-group , 12-week study of women with anemia due to bleeding from uterine leiomyomata . Serum estradiol levels were obtained at baseline and at week 12 . Patients were divided into weight quartiles according to their baseline weight in kilograms : 46- < 64 , 64- < 72 , 72- < 89 , 89-159 ( pounds-102- < 140 , 140- < 159 , 159- < 196 , 196-350 ) . RESULTS At baseline there was no statistically significant difference in estradiol level between groups as a whole or within weight quartiles . Within each group there was no relationship between weight and baseline estradiol . At week 12 , whereas estradiol levels were significantly greater in the heavier patients in each of the groups ( LA 3.75 mg , p = 0.044 ; LA 7.5 mg , p = 0.002 ) , there was no significant difference in estradiol between groups as a whole or within any of the weight quartiles . Moreover , at week 12 there was no significant difference between groups in the percentage of patients with estradiol suppressed to the menopausal range . CONCLUSION Heavier women do not benefit from a higher dose of LA depot ( 7.5 vs. 3.75 mg ) for suppression of serum levels of estradiol .
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Intervention_Pharmacological
leuprolide acetate
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Intervention_Pharmacological
gonadotropin-releasing hormone analogue leuprolide acetate ( LA )
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Intervention_Pharmacological
LA depot
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Intervention_Pharmacological
serum estradiol
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Intervention_Pharmacological
LA
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Outcome_Physical
Serum estradiol levels
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Outcome_Other
no statistically significant difference
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Outcome_Physical
estradiol level
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Outcome_Physical
estradiol levels
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Outcome_Other
significantly greater
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Outcome_Other
no significant difference in estradiol
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Outcome_Other
no significant difference
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Outcome_Physical
percentage of patients with estradiol suppressed to the menopausal range .
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Participant_Sex
women
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Participant_Sex
women
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Participant_Sex
women
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Participant_Condition
anemia
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Participant_Condition
bleeding
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Participant_Condition
uterine leiomyomata
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Participant_Sex
women