88648
document
Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering . BACKGROUND There is accumulating experimental , epidemiological , and clinical evidence of an association between anti-oxidant vitamin intake and reduced risk of coronary heart disease . Using data from the Cholesterol Lowering Atherosclerosis Study ( CLAS ) , we explored the association of self-selected supplementary antioxidant vitamin intake on the rate of progression of early preintrusive atherosclerosis . METHODS AND RESULTS CLAS was an arterial imaging trial in which nonsmoking 40- to 59-year-old men with previous coronary artery bypass graft surgery were randomized to colestipol/niacin plus diet or placebo plus diet . The rate of progression of early preintrusive atherosclerosis was determined in 146 subjects using high-resolution B-mode ultrasound quantification of the distal common carotid artery far wall intima-media thickness ( IMT ) . From the nutritional supplement database , 22 subjects had an on-trial average supplementary vitamin E intake of > or = 100 IU per day ( high users ) and 29 subjects had an average on-trial supplementary vitamin C intake of > or = 250 mg per day ( high users ) . Within the placebo group , less carotid IMT progression was found for high supplementary vitamin E users when compared with low vitamin E users ( 0.008 versus 0.023 mm/y , P = .03 ) . No effect of vitamin E within the drug group was found . No effect of vitamin C within the drug or placebo group was found . CONCLUSIONS Supplementary vitamin E intake appears to be effective in reducing the progression of atherosclerosis in subjects not treated with lipid-lowering drugs while the process is still confined to the arterial wall ( early preintrusive atherosclerosis ) .
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Intervention_Pharmacological
supplementary antioxidant vitamin
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Intervention_Pharmacological
anti-oxidant vitamin
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Intervention_Pharmacological
antioxidant vitamin
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Intervention_Pharmacological
colestipol/niacin
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Intervention_Control
placebo plus diet .
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Intervention_Pharmacological
vitamin E
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Intervention_Pharmacological
vitamin C
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Intervention_Control
placebo
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Intervention_Pharmacological
vitamin E
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Intervention_Pharmacological
vitamin E
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Intervention_Pharmacological
vitamin E
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Intervention_Pharmacological
vitamin C
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Intervention_Control
placebo
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Intervention_Pharmacological
Supplementary vitamin E
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Intervention_Pharmacological
lipid-lowering drugs
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Outcome_Physical
carotid arterial wall intima-media thickness
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Outcome_Physical
rate of progression of early preintrusive atherosclerosis
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Outcome_Physical
less carotid IMT progression
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Outcome_Physical
vitamin
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Outcome_Physical
progression of atherosclerosis
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Participant_Condition
early preintrusive atherosclerosis .
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Participant_Condition
nonsmoking
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Participant_Age
40- to 59-year-old
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Participant_Sex
men
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Participant_Condition
previous coronary artery bypass graft surgery
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Participant_Sample-size
146