81497
document
Effect of postmenopausal hormonal replacement therapy on mammographic density and parenchymal pattern . PURPOSE To measure changes and predictors of change in mammograms obtained in postmenopausal women undergoing continuous combined hormonal replacement therapy ( HRT ) . MATERIALS AND METHODS Mammograms of 41 postmenopausal women obtained before and 1 year after the initiation of HRT were evaluated blindly according to the quantitative density percentage method and the Wolfe classification system . RESULTS Mammographic densities increased compared with baseline values in 73 % of subjects ( mean increase , 6.7 % ; 95 % confidence interval , 2.5 % , 11.0 % ; P = .003 ) . A shift in Wolfe classification from lower to greater parenchymal density was noted in 24 % of subjects ( P = .016 ) . Multivariate analysis results indicated that the lower the tissue density percentage before treatment , the greater the increase in density percentage after treatment . CONCLUSION An increase in mammographic density was demonstrated in most subjects undergoing continuous combined HRT and was most pronounced in subjects with a lower baseline density percentage .
81498
Intervention_Physical
postmenopausal hormonal replacement therapy
81499
Intervention_Physical
hormonal replacement therapy ( HRT )
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Intervention_Physical
Mammograms
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Intervention_Physical
HRT
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Outcome_Physical
mammographic density
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Outcome_Physical
parenchymal pattern
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Outcome_Physical
Mammographic densities
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Outcome_Physical
lower to greater parenchymal density
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Outcome_Physical
tissue density percentage
81507
Outcome_Physical
increase in density percentage
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Outcome_Physical
mammographic density
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Participant_Condition
postmenopausal women undergoing continuous combined hormonal replacement therapy ( HRT ) .
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Participant_Condition
41 postmenopausal women obtained before and 1 year after the initiation of HRT