8187
document
Effects of glucagon-like peptide-1 ( 7-36 ) amide on motility and sensation of the proximal stomach in humans . BACKGROUND Glucagon-like peptide-1 ( 7-36 ) amide ( GLP-1 ) retards gastric emptying , reduces food intake , and inhibits antroduodenal and stimulates pyloric motility . AIMS To assess the effects of synthetic GLP-1 on fundus tone and volume waves , gastric compliance , and perception of gastric distension . SUBJECTS Eleven healthy male volunteers . METHODS Background infusions were saline , or GLP-1 at 0.3 or 0.9 pmol/ kg/min on separate days in random order . Interdigestive fundus motility was recorded by barostat ( maximum capacity of intragastric bag 1200 ml ) during basal and peptide periods of 60 minutes each . Thereafter stepwise isobaric distensions were performed with ongoing peptide infusion , and gastric sensation was scored . RESULTS Low and high loads of GLP-1 induced physiological and supraphysiological plasma immunoreactivities , respectively . GLP-1 dose dependently diminished fundus tone ( 162.9 ( 15.0 ) and 259.5 ( 17.2 ) v 121.1 ( 6.0 ) ml with saline ; p < 0.0001 ) . It greatly reduced volume waves and total volume displaced by these events ( p < 0.0001 ) . Gastric compliance derived from isobaric distension rose in a dose related manner ( 42.6 ( 5.5 ) and 63.6 ( 7.7 ) v 27.0 ( 3.5 ) ml/mm Hg ; p=0.0004 ) with a concomitant reduction of the pressure at half maximum bag volume ( 6.4 ( 0.4 ) and 5.5 ( 0.4 ) v 7.2 ( 0.1 ) mm Hg ; p < 0.0001 ) . GLP-1 did not change perception of isobaric distension but reduced the perception score related to corresponding bag volume ( p < 0.0001 ) . CONCLUSIONS GLP-1 is a candidate physiological inhibitory regulator of fundus motility . It allows the stomach to afford a larger volume without increase in sensation .
8188
Intervention_Pharmacological
glucagon-like peptide-1 ( 7-36 ) amide
8189
Intervention_Pharmacological
Glucagon-like peptide-1 ( 7-36 ) amide ( GLP-1 )
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Intervention_Pharmacological
synthetic GLP-1
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Intervention_Control
saline
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Intervention_Pharmacological
GLP-1
8193
Intervention_Pharmacological
GLP-1
8194
Intervention_Pharmacological
GLP-1
8195
Intervention_Pharmacological
GLP-1
8196
Intervention_Pharmacological
GLP-1
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Outcome_Physical
motility and sensation of the proximal stomach
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Outcome_Physical
fundus tone and volume waves
8199
Outcome_Physical
gastric compliance
8200
Outcome_Physical
perception of gastric distension
8201
Outcome_Physical
Interdigestive fundus motility
8202
Outcome_Physical
gastric sensation
8203
Outcome_Physical
physiological and supraphysiological plasma immunoreactivities
8204
Outcome_Physical
fundus tone
8205
Outcome_Physical
volume waves and total volume displaced
8206
Outcome_Physical
Gastric compliance
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Outcome_Physical
pressure
8208
Outcome_Physical
isobaric distension
8209
Outcome_Physical
perception score
8210
Outcome_Physical
fundus motility
8211
Outcome_Physical
increase in sensation
8212
Participant_Sample-size
Eleven
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Participant_Condition
healthy
8214
Participant_Sex
male