77691
document
Effects of piracetam on regional cerebral blood flow and mental functions in patients with organic dementia . The effects of piracetam ( Nootropil , UCB6215 ) on mental functions and on regional cerebral blood flow ( rCBF ) were investigated in eight patients in the presenile age who displayed symptoms of moderate dementia . The double-blind crossover design included nine measurement occasions , each involving rCBF measurement by the 133-Xe inhalation method , ratings of symptoms of dementia , personality changes , and side effects , and a psychometric investigation . Three investigations were included in each of three treatment periods . The first investigation in a period was made without medication . Then either placebo or piracetam 4.8 g/day or 9.6 g/day was given during four weeks with measurements after 2 weekks and 4 weeks . There were intervals of 4 weeks without medication between the treatment periods . Piracetam had no significant effect on either mental functions or rCBF .
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Intervention_Pharmacological
piracetam
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Intervention_Pharmacological
piracetam
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Intervention_Pharmacological
133-Xe inhalation method
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Intervention_Control
placebo
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Intervention_Pharmacological
piracetam
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Intervention_Pharmacological
Piracetam
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Outcome_Physical
cerebral blood flow
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Outcome_Mental
mental functions
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Outcome_Mental
mental functions
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Outcome_Physical
regional cerebral blood flow ( rCBF )
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Outcome_Physical
rCBF measurement
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Outcome_Mental
mental functions
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Outcome_Mental
rCBF
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Participant_Condition
patients with organic dementia .
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Participant_Sample-size
eight
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Participant_Condition
patients in the
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Participant_Age
presenile
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Participant_Condition
age who displayed symptoms of moderate dementia .