38884
document
Netilmicin in the neonate : pharmacokinetic analysis and influence of parenteral nutrition . OBJECTIVE The aim of this study was to investigate the impact of parenteral nutrition on netilmicin pharmacokinetics in critically ill neonates during the first week of life . METHOD A total of 200 neonates ( gestational ages 26.4-41 weeks ) treated with netilmicin ( 4-5 mg/kg in extended dosing intervals ) for postnatal sepsis in the first week of life received either fluid therapy or parenteral nutrition . Netilmicin peak and trough serum concentrations were monitored and netilmicin pharmacokinetic parameters were compared with and without parenteral nutrition . RESULTS There were no statistically significant differences between the pharmacokinetic parameters of netilmicin ( volume of distribution , elimination half-life , clearance ) in critically ill neonates > 32 weeks during the first week of life that received either fluid therapy or parenteral nutrition . For neonates < 32 weeks this comparison was not feasible as the majority were parenterally fed . CONCLUSION Provision of parenteral nutrition ( versus fluid therapy ) in critically ill neonates > 32 weeks did not significantly affect netilmicin pharmacokinetics and therefore does not require modification of recommended netilmicin dosage regimens .
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Intervention_Pharmacological
Netilmicin
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Intervention_Pharmacological
parenteral nutrition
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Intervention_Pharmacological
netilmicin
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Intervention_Pharmacological
netilmicin
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Intervention_Pharmacological
parenteral nutrition
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Intervention_Pharmacological
parenteral nutrition
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Intervention_Pharmacological
parenteral nutrition
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Outcome_Physical
pharmacokinetics
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Outcome_Physical
pharmacokinetic parameters of netilmicin
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Outcome_Other
volume of distribution
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Outcome_Other
elimination half-life
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Outcome_Physical
clearance
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Outcome_Physical
netilmicin pharmacokinetics
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Participant_Sample-size
200
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Participant_Condition
netilmicin