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document
Dissociation between cortical activation and cognitive performance under pharmacological blood pressure elevation in chronic hypotension . The present study explored the impact of pharmacological blood pressure elevation on cortical activation and reaction time in chronic hypotension . Effects of the sympathomimetic etilefrine were investigated in 50 hypotensive persons based on a randomized , placebo-controlled double blind design . As an indicator of cortical excitability , the contingent negative variation ( CNV ) , induced by a constant foreperiod reaction time task , was assessed at frontal ( F3 , Fz , F4 ) and central ( C3 , Cz , C4 ) scalp sites . Etilefrine provoked a decrease in the frontal and central CNV . In contrast , shorter reaction times were observed following drug administration . The degree of pharmacologically induced blood pressure elevation was correlated to CNV attrition as well as to performance enhancement . Inhibitory effects of baroreceptor activation on cortical excitability and enhanced cerebral blood flow are considered to be involved in mediating the effects of blood pressure elevation on cerebral functioning . Implications for the treatment of chronic hypotension are discussed .
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Intervention_Pharmacological
pharmacological blood pressure elevation
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Intervention_Pharmacological
sympathomimetic etilefrine
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
Etilefrine
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Outcome_Physical
frontal and central CNV .
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Outcome_Physical
reaction times
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Outcome_Physical
induced blood pressure elevation
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Outcome_Physical
blood pressure elevation
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Outcome_Physical
chronic hypotension
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Participant_Condition
chronic hypotension
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Participant_Sample-size
50
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Participant_Condition
hypotensive