81820
document
Angiotensin-converting enzyme inhibition does not suppress plasma angiotensin II increase during exercise in humans . Physical effort stimulates the reninangiotensin system ( RAS ) . We studied the effect of an angiotensin-converting enzyme inhibitor ( ACE inhibitor ) in a double-blind placebo-controlled study , on eight volunteers undergoing physical stress on an ergometric bicycle . The effects of captopril ( C ) ( 50 mg , three times daily for 3 days ) on arterial pressure ( AP ) , O2 consumption ( VO2 ) , variations in auricular natriuretic factor ( ANF ) , renin , angiotensin II ( AII ) plasma levels , as well as glomerular filtration rate ( GFR ) and microalbuminuria ( MA ) were evaluated . The different parameters were compared by analysis of variance ( ANOVA ) . The pressure profile and VO2 were not modified by ACE inhibitor . Exercise stimulates release of renin ; this action was greater with captopril administration ( treatment effect : p < 10 ( -4 ) , indicating blockade of the RAS . This inhibition was incomplete because AII levels increased markedly when captopril was given ( no treatment effect : p < 0.37 ) . Finally , ACE inhibitor resulted in decreased GFR ( p = 115 +/- 5.8 ml/mn-1 , C = 91.1 +/- 4 , p < 0.05 ) with exercise without modification of MA . ACE inhibitor administration does not modify the physical performance of nonathletic subjects ; AII is significantly increased with exercise despite captopril treatment ; ACE inhibitor decreases GFR significantly but does not influence MA with prolonged physical effort .
81821
Intervention_Pharmacological
Angiotensin-converting enzyme inhibition
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Intervention_Pharmacological
angiotensin-converting enzyme inhibitor ( ACE inhibitor )
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
ACE inhibitor .
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
captopril
81827
Intervention_Pharmacological
ACE inhibitor
81828
Intervention_Pharmacological
ACE inhibitor
81829
Intervention_Physical
administration
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Intervention_Pharmacological
ACE inhibitor
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Outcome_Physical
pressure ( AP ) , O2 consumption ( VO2 ) , variations in auricular natriuretic factor ( ANF ) , renin , angiotensin II ( AII ) plasma levels , as well as glomerular filtration rate ( GFR ) and microalbuminuria ( MA )
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Outcome_Physical
GFR
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Outcome_Physical
GFR
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Participant_Condition
exercise
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Participant_Sample-size
eight
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Participant_Condition
volunteers
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Participant_Condition
physical stress