14868
document
Analgesic efficacy of low-dose diclofenac versus paracetamol and placebo in postoperative dental pain . AIMS To compare the efficacy and safety of diclofenac-K ( 12.5 mg ) vs paracetamol ( 500 mg ) and placebo given in a flexible dosage regimen to treat pain resulting from extraction of impacted third molar teeth . METHODS This was a 2-day , double-blind , double-dummy , randomized , parallel-group , placebo-controlled study of diclofenac-K ( 12.5 mg ) tablets vs paracetamol ( 500 mg ) tablets and placebo in patients with moderate or severe pain within 8 hours of extraction of impacted third molars . RESULTS After the first 2-tablet dose , patients took on average 2.5 additional tablets of diclofenac-K or 2.4 tablets of paracetamol , almost all as 1-tablet doses . Most placebo patients discontinued by taking rescue medication ( ibuprofen 200 mg ) on the first day . Pain relief after the initial dose of diclofenac-K ( 2 x 12.5 mg ) was superior to placebo ( P < .01 for all efficacy outcomes ) and comparable to paracetamol ( 2 x 500 mg ) . About 30 % of patients in each active treatment group took rescue medication during the study , compared to 78 % on placebo . About 70 % in each active treatment group considered the overall pain relief to be " some , " " a lot , " or " complete " compared to only 15 % on placebo . The incidence of adverse events in each active treatment group was low and comparable between the treatments . CONCLUSION An initial double-dose of diclofenac-K ( 2 x 12.5 mg ) or paracetamol ( 2 x 500 mg ) adequately relieved the most intense postoperative pain , and the flexible multiple dose regimen ( 1 or 2 tablets ) maintained adequate pain relief thereafter . Most patients needed only 1-tablet doses following the initial 2-tablet dose .
14869
Intervention_Pharmacological
diclofenac
14870
Intervention_Pharmacological
paracetamol
14871
Intervention_Control
placebo
14872
Intervention_Pharmacological
diclofenac-K
14873
Intervention_Pharmacological
paracetamol
14874
Intervention_Control
placebo
14875
Intervention_Control
placebo-controlled
14876
Intervention_Pharmacological
diclofenac-K ( 12.5 mg ) tablets vs paracetamol
14877
Intervention_Control
placebo
14878
Intervention_Pharmacological
diclofenac-K
14879
Intervention_Pharmacological
paracetamol
14880
Intervention_Control
placebo
14881
Intervention_Pharmacological
diclofenac-K
14882
Intervention_Control
placebo
14883
Intervention_Pharmacological
paracetamol
14884
Intervention_Control
placebo
14885
Intervention_Control
placebo
14886
Intervention_Pharmacological
diclofenac-K
14887
Intervention_Pharmacological
paracetamol
14888
Outcome_Pain
Pain relief
14889
Outcome_Pain
overall pain relief
14890
Outcome_Adverse-effects
incidence of adverse events
14891
Outcome_Pain
postoperative pain
14892
Outcome_Pain
pain relief
14893
Participant_Condition
postoperative dental pain
14894
Participant_Condition
pain
14895
Participant_Condition
extraction of impacted third molar teeth
14896
Participant_Condition
moderate or severe pain
14897
Participant_Condition
extraction of impacted third molars
14898
Participant_Condition
postoperative pain