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document
The effect of L-arginine and citrulline on endothelial function in patients in heart failure with preserved ejection fraction . BACKGROUND To evaluate the effect of the amino acids L-arginine and citrulline on endothelial function in patients in stable diastolic and right heart failure using photoplethysmography . METHODS Thirty patients from the Heart Failure Clinic of the Instituto Nacional de Ciencias Médicas y Nutrición " Salvador Zubirán " underwent photoplethysmography using the hyperemia technique . Index finger flow was assessed at baseline and after ischemia every 30 s by maximum amplitude time ( MAT ) , total time of the curve ( TT ) and the index of the two ( MAT/TT < 30 = normal ) before and after the administration of L-arginine ( 8 g/day in two doses , n = 15 ) or citrulline ( 3 g/day in one dose , n = 15 ) for 60 days in addition to optimal pharmacological treatment . RESULTS There were no statistically significant differences between the two groups at baseline . After the intervention , the MAT/TT index of all patients normalized in each evaluation period with statistically significant differences . Basal L-arginine group = 38.75 ± 11.52 , final 23.32 ± 6.08 , p = 0.007 and basal citrulline group = 41.4 ± 13.47 , final 23.65 ± 6.74 , p = 0.007 at 60-90 s. Post-ischemia : basal L-arginine 36.60 ± 11.51 , final 18.81 ± 15.13 , p = 0.004 and basal citrulline = 49.51 ± 15.17 , final 27.13 ± 7.87 , p = 0.003 . CONCLUSIONS The administration of L-arginine and citrulline has a beneficial effect on endothelial function as shown by the normalized MAT/TT index . It probably improves systemic and pulmonary hemodynamics , which could help in the treatment of diastolic heart failure .
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Intervention_Pharmacological
L-arginine and citrulline
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Intervention_Pharmacological
amino acids L-arginine and citrulline
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Outcome_Physical
endothelial function
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Outcome_Physical
endothelial function
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Participant_Condition
patients in heart failure with preserved ejection fraction
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Participant_Condition
patients in stable diastolic and right heart failure
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Participant_Sample-size
Thirty patients
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Participant_Condition
Heart Failure Clinic of the Instituto Nacional de Ciencias Médicas y Nutrición " Salvador Zubirán " underwent photoplethysmography using the hyperemia technique
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Participant_Condition
treatment of diastolic heart