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document
Treatment of anal fissures using a combination of minoxidil and lignocaine : a randomized , double-blind trial . AIM Anal fissures are associated with hypertonia of the internal anal sphincter and pain . We evaluated the efficacy of local application of a combination of minoxidil and lignocaine in healing anal fissures . METHODS In this prospective , randomized , double-blind study , 90 patients with anal fissure were recruited . Patients received local applications of ointments containing 5 % lignocaine ( n=28 ) , 0.5 % minoxidil ( n=36 ) , or both ( n=26 ) . Healing of anal fissure at 6 weeks was used as the primary end-point . RESULTS Rates of complete healing of fissure were similar in the three groups ( lignocaine alone 8/27 , minoxidil alone 10/34 , combination 7/22 ; p=ns ) . Mean ( SD ) time taken for complete healing with combination treatment [ 1.9 ( 0.6 ) weeks ] was significantly shorter than that with minoxidil alone ( 3.1 [ 1.7 ] weeks ; p=0.001 ) or with lignocaine alone ( 3.3 [ 0.8 ] weeks ; p=0.002 ) . Rates of pain relief were similar in the three groups . Stoppage of bleeding occurred more often with combination treatment than with lignocaine alone . No patient had systemic or local side effects . CONCLUSION Combination treatment with minoxidil and lignocaine helps in faster healing of anal fissures and provides better symptomatic relief than either drug alone .
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Intervention_Pharmacological
minoxidil
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Intervention_Pharmacological
lignocaine :
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Intervention_Pharmacological
minoxidil
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Intervention_Pharmacological
lignocaine
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Intervention_Pharmacological
local applications of ointments containing 5 % lignocaine ( n=28 ) , 0.5 % minoxidil
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Intervention_Pharmacological
both
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Intervention_Pharmacological
lignocaine
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Intervention_Pharmacological
minoxidil
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Intervention_Pharmacological
minoxidil
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Intervention_Pharmacological
lignocaine
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Intervention_Pharmacological
lignocaine
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Intervention_Pharmacological
minoxidil
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Intervention_Pharmacological
lignocaine
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Outcome_Physical
Healing of anal fissure
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Outcome_Physical
Rates of complete healing of fissure
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Outcome_Physical
Mean ( SD ) time taken for complete healing with combination treatment
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Outcome_Physical
Rates of
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Outcome_Pain
pain relief
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Outcome_Physical
Stoppage of bleeding
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Outcome_Adverse-effects
systemic or local side effects
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Participant_Sample-size
90
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Participant_Condition
anal fissure