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document
Enhanced baroreceptor control of the cardiovascular system by polyunsaturated Fatty acids in heart failure patients . OBJECTIVES The intention of this study was to test the hypothesis that , in heart failure patients , dietary supplementation of polyunsaturated fatty acids ( PUFA ) enhances arterial baroreceptor control of the cardiovascular system . BACKGROUND Administration of PUFA reduces the risk of life-threatening arrhythmias in patients surviving myocardial infarction . This might result from potentiation of arterial baroreflexes , but whether or not PUFA enhance baroreflex function has never been studied in humans . METHODS Patients with post-myocardial infarction left ventricular dysfunction underwent beat-to-beat blood pressure ( BP ) ( Finapres , Ohmeda Inc. , Englewood , Colorado ) and R-R interval ( electrocardiogram ) recording ; baroreceptor reflexes were assessed from the bradycardic and depressor responses to graded neck suction ( NS ) as well as by computation of the alpha " spontaneous " baroreflex sensitivity index . Assessments were repeated after prolonged treatment with PUFA ( 2 g/die , n = 15 ) or placebo ( n = 10 ) . RESULTS Baseline BP and R-R interval were unaffected by PUFA . Both reflex depressor and bradycardic responses to NS increased after PUFA ( respectively from -0.09 +/- 0.01 to -0.16 +/- 0.01 mm Hg x mm Hg ( -1 ) , p < 0.01 , and from 1.25 +/- 0.9 to 1.76 +/- 1.1 ms x mm Hg ( -1 ) , p < 0.04 ) but not after placebo . The spontaneous baroreflex sensitivity increased in the PUFA ( from 8.99 +/- 1.4 to 12.2 +/- 1.2 ms x mm Hg ( -1 ) , p < 0.02 ) but not in the placebo group . Polyunsaturated fatty acids ( but not placebo ) treatment also significantly increased R-R interval total variance and low-frequency and high-frequency spectral powers . CONCLUSIONS Dietary PUFA supplementation markedly potentiates baroreflex function and enhances heart rate variability in patients with stable congestive heart failure .
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Intervention_Pharmacological
polyunsaturated Fatty acids
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Intervention_Pharmacological
dietary supplementation of polyunsaturated fatty acids ( PUFA )
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Intervention_Pharmacological
PUFA
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Intervention_Pharmacological
PUFA
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Intervention_Pharmacological
PUFA
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Intervention_Control
placebo
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Intervention_Pharmacological
PUFA .
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Intervention_Pharmacological
PUFA
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Intervention_Control
placebo .
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Intervention_Pharmacological
PUFA
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Intervention_Control
placebo
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Intervention_Pharmacological
Polyunsaturated fatty acids
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Intervention_Control
placebo
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Intervention_Pharmacological
Dietary PUFA supplementation
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Outcome_Physical
Baseline BP
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Outcome_Physical
R-R interval
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Outcome_Physical
reflex depressor and bradycardic responses to NS
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Outcome_Physical
spontaneous baroreflex sensitivity
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Outcome_Physical
R-R interval total variance
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Outcome_Physical
heart rate variability
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Participant_Condition
heart failure patients .
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Participant_Condition
heart failure patients