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document
The effect of fasting on total serum bilirubin concentrations . Thirty-seven healthy volunteers , 19 of whom had consistently elevated total serum bilirubin ( TSB ) concentrations , took part in an open , randomised cross-over study to determine the effect of fasting on TSB concentrations . The study comprised of two treatments . During one treatment period volunteers ate a standard supper but fasted for 24 h thereafter . During the other treatment period volunteers ate a standard supper , snacks , breakfast and lunch . TSB concentrations were measured at regular intervals . In both the normal and high bilirubin groups , minimum TSB values were recorded 4 h after the supper . A 24 h fast more than doubled TSB concentration from baseline values in both the normal and high bilirubin groups . A clinically relevant rise in TSB took place after 12 h into the fasting period ( TSB of 17.3 mumol l-1 in the fasted group vs 14.0 mumol l-1 in the non-fasted group ) . When designing a clinical trial , selecting volunteers , or judging the tolerance of a new drug , the rise in TSB caused by fasting must therefore be taken into account , particularly in trials where volunteers or patients fast before entering the study .
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Intervention_Other
fasting
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Intervention_Other
fasting
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Intervention_Physical
ate a standard supper but
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Intervention_Other
fasted for 24 h
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Intervention_Physical
thereafter
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Intervention_Physical
standard supper , snacks , breakfast and lunch
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Outcome_Physical
total serum bilirubin concentrations .
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Outcome_Physical
total serum bilirubin ( TSB ) concentrations
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Outcome_Physical
TSB concentrations
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Outcome_Physical
minimum TSB values
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Outcome_Physical
more than doubled TSB concentration
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Outcome_Physical
rise in TSB
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Outcome_Physical
TSB