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document
Effect of ischaemic preconditioning , cardiopulmonary bypass and myocardial ischaemic/reperfusion on free radical generation in CABG patients . OBJECTIVE To investigate the free radicals ( FR ) generation after ischaemic preconditioning and cardiopulmonary bypass and during reperfusion in CABG patients , and the role of ischaemic preconditioning . METHODS Forty-three CABG patients were randomised into an ischaemic preconditioning and a control group . The protocol for ischaemic preconditioning was two cycles of 2-min ischaemia followed by 3-min reperfusion . Free radicals were measured using electron spin resonance spectroscopy . Global and right heart functions were collected . RESULTS The free radicals generation in coronary sinus blood in the ischaemic preconditioning group was 9.7 and 16.6 % after the ischaemic preconditioning protocol and 10 min after declamping , 6.8 and 13.3 % in the controls . The free radicals in arterial samples were , respectively , 21 , 14 , 10 and 9 % at 10 min , 1 , 2 and 24 h after reperfusion . Cardiac index ( CI ) and right ventricular ejection fraction ( RVEF ) were improved by ischaemic preconditioning . CONCLUSION Both ischaemic preconditioning and cardiopulmonary bypass induced free radicals generation . Although ischaemic preconditioning had no effect on free radicals generation after the operation , it protected against postoperative stunning .
6531
Intervention_Physical
ischaemic preconditioning
6532
Intervention_Surgical
cardiopulmonary bypass
6533
Intervention_Surgical
myocardial ischaemic/reperfusion
6534
Intervention_Physical
ischaemic preconditioning
6535
Intervention_Surgical
cardiopulmonary bypass
6536
Intervention_Physical
ischaemic preconditioning
6537
Intervention_Surgical
.
6538
Intervention_Physical
ischaemic preconditioning
6539
Intervention_Physical
ischaemic preconditioning
6540
Intervention_Physical
ischaemia
6541
Intervention_Physical
reperfusion
6542
Intervention_Physical
ischaemic preconditioning
6543
Intervention_Physical
ischaemic preconditioning
6544
Intervention_Physical
ischaemic preconditioning
6545
Intervention_Surgical
.
6546
Intervention_Physical
ischaemic preconditioning
6547
Intervention_Surgical
cardiopulmonary bypass
6548
Intervention_Physical
ischaemic preconditioning
6549
Outcome_Physical
free radical generation
6550
Outcome_Physical
Free radicals
6551
Outcome_Physical
Global and right heart functions
6552
Outcome_Physical
free radicals generation in coronary sinus blood
6553
Outcome_Physical
free radicals in arterial samples
6554
Outcome_Physical
Cardiac index ( CI )
6555
Outcome_Physical
right ventricular ejection fraction ( RVEF )
6556
Outcome_Physical
free radicals generation
6557
Outcome_Physical
free radicals generation
6558
Participant_Condition
CABG
6559
Participant_Condition
CABG
6560
Participant_Sample-size
Forty-three
6561
Participant_Condition
CABG