88335
document
Adjvant treatment of tongue and floor of the mouth cancers . Since January 1974 , 95 patients with anterior tongue and floor of the mouth cancers were included in a randomized trial . After stratification according to staging and initial treatment , one-third of the patients received chemotherapy for 2 years ( methotrexate 400 mg followed by citrovorum factor 100 mg + bleomycin 60 mg/week , during the first 15 weeks ) , one-third of the patients received immunotherapy with weekly C. parvum injections during 2 years , while the remaining third did not receive any treatment . If adjuvant treatment seems to delay recurrence it did not significantly decrease the recurrence rate . Survival is also not signigicantly modified by adjuvant treatment and was better for patients with small tumors . Patients who previously received radiotherapy did not benefit from adjuvant therapy .
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Intervention_Pharmacological
Adjvant treatment
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Intervention_Pharmacological
chemotherapy for 2 years ( methotrexate 400 mg followed by citrovorum factor 100 mg + bleomycin 60 mg/week , during the first 15 weeks )
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Intervention_Pharmacological
one-third of the patients received immunotherapy with weekly C. parvum injections during 2 years
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Intervention_Control
remaining third did not receive any treatment
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Intervention_Pharmacological
adjuvant
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Intervention_Physical
radiotherapy
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Intervention_Pharmacological
adjuvant therapy
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Outcome_Other
delay recurrence
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Outcome_Other
recurrence rate
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Outcome_Mortality
Survival
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Participant_Condition
mouth cancers
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Participant_Sample-size
95
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Participant_Condition
anterior tongue and floor of the mouth cancers
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Participant_Sample-size
one-third
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Participant_Sample-size
one-third
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Participant_Sample-size
third