85701
document
Timing of antibiotic administration in knee replacement under tourniquet . Cephamandole levels in serum and drain fluid were measured in 32 knee replacement operations to determine the benefit of an intravenous dose of antibiotic at the time of tourniquet deflation . Concentrations of cephamandole in drain fluid were directly proportional to the serum concentration at the time of tourniquet release . A 'tourniquet-release ' dose of antibiotic increased drain fluid concentration threefold .
85702
Intervention_Physical
antibiotic administration
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Intervention_Pharmacological
Cephamandole
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Intervention_Pharmacological
cephamandole
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Intervention_Pharmacological
'tourniquet-release ' dose of antibiotic
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Outcome_Physical
Cephamandole levels in serum and drain fluid
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Outcome_Physical
cephamandole in drain fluid
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Outcome_Physical
drain fluid concentration
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Participant_Condition
knee replacement under tourniquet .
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Participant_Sample-size
32
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Participant_Condition
knee replacement operations