23692
document
[ Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase ] . OBJECTIVE To evaluate the effect of Yufeining , a traditional Chinese medicine , on induced sputum interleukin-8 ( IL-8 ) in patients with chronic obstructive pulmonary disease ( COPD ) at the stable phase . METHODS Thirty-six patients with COPD were divided into trial group ( 18 cases ) and control group ( 18 cases ) randomly . The trial group was treated with Yufeining pills taken orally for half a year ; the control group was not given any medicine . Routine lung function was recorded before and after treatment . Total cell count ( TCC ) , differential cell counts ( DCCs ) and IL-8 in induced sputum were determined at the baseline and 6 months later . RESULTS The indices of lung function improved significantly after 6 months ' treatment in trial group ( P < 0.05 ) ; TCC and absolute neutrophil count decreased significantly compared with baseline in the trial group ( P < 0.05 ) ; Sputum IL-8 concentration dropped significantly after 6 months ' treatment , from a mean of 5.216 +/- 2.914 microg/L to 4.222 +/- 2.140 microg/L ( P < 0.05 ) . There were insignificant changes in the parameters in the control group between baseline and 6 months later . CONCLUSION Yufeining could improve lung function , decrease sputum TCC , absolute neutrophil count and IL-8 concentration , and relieve airway inflammation in patients with COPD in the stable phase .
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Intervention_Pharmacological
Yufeining
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Intervention_Pharmacological
Yufeining
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Intervention_Pharmacological
Yufeining pills
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Intervention_Control
control group was not given any medicine .
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Outcome_Physical
sputum interleukin-8
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Outcome_Physical
induced sputum interleukin-8 ( IL-8 )
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Outcome_Physical
lung function
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Outcome_Physical
Total cell count ( TCC ) , differential cell counts ( DCCs ) and IL-8 in induced sputum
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Outcome_Physical
indices of lung function
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Outcome_Physical
TCC and absolute neutrophil count
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Outcome_Physical
Sputum IL-8 concentration
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Outcome_Physical
lung function
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Outcome_Physical
sputum TCC , absolute neutrophil count and IL-8 concentration
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Outcome_Physical
airway inflammation
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Participant_Condition
chronic obstructive pulmonary disease
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Participant_Condition
stable phase
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Participant_Condition
chronic obstructive pulmonary disease ( COPD )
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Participant_Condition
stable phase
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Participant_Sample-size
Thirty-six
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Participant_Condition
COPD
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Participant_Condition
COPD