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Quick change versus double pump while changing the infusion of inotropes : an experimental study . BACKGROUND Quick change ( QC ) and double pumping ( DP ) are common methods of substituting the infusion of inotropes given through intravenous pump . AIMS The aim of the study was to compare two methods in respect with the variation in mean arterial pressure ( MAP ) . The hypothesis was that the DP method could be the most effective in achieving haemodynamic stability . DESIGN The study is a randomized research in an open randomized clinical trial . METHODS The study took place at the Paediatric Intensive Care Unit of Padua Hospital . It considered patients of 0-36 months , not premature , treated with inotropic infusion with monitoring of blood pressure . The research obtained the approval of the Hospital Research Ethics committee and parents signed informed consent . Comparison of the two groups made use of the Wilcoxon test for the continuous variables and the Fisher 's exact test for the comparison of frequencies , at significance value of 5 % . The data were registered in an Excel spreadsheet and analysed with SAS . RESULTS The sample comprised 30 patients of age between 1 and 27 months , of whom 13 ( 43 % ) were male . They were all affected by cardiac , respiratory or infective pathology , all of them intubated and on artificial respiratory support , sedated and infused with dopamine . The characteristics of the patients of the two groups did not differ significantly . The percentage variation of the baseline value of MAP after 30 min from starting the treatment between the two methods was not statistically significant ( p = 0.85 ) . The 95 % confidence interval for the difference in the percentage variation of MAP between the two groups was ( -3.1 , +3.7 ) . From a clinical perspective , the methods are to be considered equivalent . CONCLUSIONS The study was conducted on a limited sample ; no statistically significant differences were detected ; QC is the quickest and more cost-effective method .
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Intervention_Physical
Quick change
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Intervention_Educational
versus
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Intervention_Physical
double pump
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Intervention_Physical
Quick change ( QC )
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Intervention_Educational
and
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Intervention_Physical
double pumping ( DP )
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Intervention_Physical
DP
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Intervention_Physical
inotropic infusion
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Intervention_Physical
QC
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Outcome_Physical
mean arterial pressure ( MAP )
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Outcome_Physical
haemodynamic stability
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Outcome_Physical
blood pressure
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Outcome_Physical
MAP
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Outcome_Physical
MAP
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Outcome_Other
quickest
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Outcome_Other
cost-effective
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Participant_Condition
Paediatric Intensive Care Unit of Padua Hospital .
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Participant_Condition
Hospital Research Ethics committee
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Participant_Condition
The study was conducted on a limited sample ;