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document
1H nuclear magnetic resonance-based metabolomic study on efficacy of Qingrehuatan decoction against abundant phlegm-heat syndrome in young adults with essential hypertension . OBJECTIVE To observe the influence of Qingrehuatan decoction ( QRHT ) on serum metabolic profile in young essential hypertension ( YEH ) patients with abundant phlegm-heat syndrome and provide a basis for treatment with the decoction . METHODS Twelve male YEH patients were randomly selected and serum samples were collected for examination before and after 4 weeks of the treatment with QRHT . Twelve healthy males were randomly selected and their serum samples were collected as a control . All serum samples were detected using metabolomic technology with 1H nuclear magnetic resonance . Differences in metabolites were studied by principal component analysis and partial least squares-discriminate analysis , which produced scores and loadings plots . RESULTS After 4 weeks of treatment , serum substances could be distinguished between the YEH patients with abundant phlegm-heat syndrome and the control patients . The specific serum endog- enous metabolites tended to improve after the treatment . QRHT can appropriately increase the levels of glucose , lactic acid , citric acid , high-density lipoprotein , phosphatidylcholine , glycerophosphate choline , hydroxybutyrate , alanine , and glutamate . QRHT could also decrease the levels of low-density lipoprotein/very low-density lipoprotein , lipids , N-acetyl glycoprotein , and O-acetyl glycoprotein . CONCLUSION QRHT can effectively ameliorate metabolic disorders in YEH Patients with abundant phlegm-heat syndrome . 1H NMR-based metabolomic technology can provide an objective basis for the treatment of YEH patients with abundant phlegm-heat syndrome using QRHT .
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Intervention_Pharmacological
Qingrehuatan decoction
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Intervention_Pharmacological
Qingrehuatan decoction ( QRHT )
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Intervention_Pharmacological
QRHT .
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Intervention_Pharmacological
QRHT
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Intervention_Pharmacological
QRHT
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Intervention_Pharmacological
QRHT
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Outcome_Other
efficacy
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Outcome_Physical
serum metabolic profile
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Outcome_Physical
serum endog- enous metabolites
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Outcome_Physical
levels of glucose , lactic acid , citric acid , high-density lipoprotein , phosphatidylcholine , glycerophosphate choline , hydroxybutyrate , alanine , and glutamate .
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Outcome_Physical
levels of low-density lipoprotein/very low-density lipoprotein , lipids , N-acetyl glycoprotein , and O-acetyl glycoprotein .
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Outcome_Physical
metabolic disorders
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Participant_Age
young adults
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Participant_Condition
hypertension
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Participant_Age
young
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Participant_Condition
hypertension
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Participant_Condition
abundant phlegm-heat syndrome
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Participant_Sample-size
Twelve
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Participant_Sex
male
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Participant_Sample-size
Twelve
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Participant_Sex
males
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Participant_Condition
phlegm-heat syndrome