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document
Does an educational leaflet improve self-reported adherence to therapy in osteoporosis ? The OPTIMA study . INTRODUCTION Adherence to treatment in osteoporosis remains poor . The aim of this study was to evaluate the effects of an educational leaflet on adherence to medication and to assess the association between adherence and health-related quality of life ( HRQOL ) . METHODS A naturalistic , observational , multi-center , prospective study of 12 months ' follow-up was performed . Consecutive post-menopausal women aged 50 years to 86 years starting treatment with raloxifene according to daily practice were enrolled from 126 primary care offices in Spain . The women were assigned to two study groups . Group A received an educational leaflet with general information about osteoporosis ; group B followed current practice . To assess adherence to medication and HRQOL , the Morisky test and the EuroQoL questionnaire were administered . A total of 745 post-menopausal women ( group A , n=366 ; group B n=379 ) , with a mean age of 62 years , were included . RESULTS Most patients in both study groups showed high adherence to raloxifene at the 3-month visit : 56.3 % vs 62.7 % for groups A and B , respectively ; this proportion at the 12-month visit was 47.4 % ( P=0.15 ) and 52.5 % ( P=0.02 ) , respectively . At baseline , " pain/discomfort " was the dimension showing the highest percentage of women reporting problems : 86.4 % vs 83.2 % in groups A and B , respectively ( P=0.22 ) . HRQOL improved in both groups throughout the study , with an overall mean increment in the EuroQoL visual analog scale ( EQ VAS ) of 9.2 at 12 months ( P < 0.01 ) . Correlations between adherence and HRQOL were weak . After receiving an educational leaflet , young post-menopausal women suffering osteoporosis did not show improvement in adherence to therapy . HRQOL improved at 12-month follow-up under treatment . CONCLUSION No consistent correlation between adherence and HRQOL was found .
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Intervention_Educational
educational leaflet
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Intervention_Educational
educational leaflet
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Intervention_Pharmacological
raloxifene
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Intervention_Educational
educational leaflet with general information about osteoporosis ;
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Intervention_Control
current practice
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Intervention_Pharmacological
raloxifene
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Intervention_Educational
educational leaflet
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Outcome_Other
adherence
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Outcome_Physical
Adherence
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Outcome_Other
adherence
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Outcome_Physical
adherence
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Outcome_Physical
health-related quality of life ( HRQOL )
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Outcome_Physical
adherence to medication
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Outcome_Physical
HRQOL
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Outcome_Physical
Morisky test
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Outcome_Physical
EuroQoL
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Outcome_Pain
" pain/discomfort "
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Outcome_Physical
HRQOL
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Outcome_Physical
EuroQoL visual analog scale ( EQ VAS )
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Outcome_Physical
adherence
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Outcome_Physical
HRQOL
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Outcome_Mental
adherence to therapy .
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Outcome_Physical
HRQOL
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Outcome_Physical
adherence
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Outcome_Physical
HRQOL
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Participant_Condition
osteoporosis
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Participant_Age
aged 50 years to 86 years
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Participant_Sex
women
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Participant_Sample-size
745
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Participant_Sample-size
n=366
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Participant_Age
mean age of 62 years
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Participant_Condition
post-menopausal