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document
Modest antihypertensive effect of epanolol , a beta 1-selective receptor blocker with beta 1 agonist activity : an acute and long-term hemodynamic study at rest and during exercise and double crossover comparison with atenolol on ambulatory blood pressure . Beta-blockers with less cardiodepressive effect than traditional nonselective beta ( 1+2 ) -blocking agents could be useful in the treatment of hypertension , provided the reduction in blood pressure was satisfactory . Epanolol , a selective beta 1-receptor blocker with intrinsic sympathomimetic activity , induced a fall in intraarterial pressure of 8 % at rest sitting and 11 % during 100 W bicycle exercise after the first dose of 200 mg in 12 patients with essential hypertension . Heart rate , stroke index , and cardiac index initially fell by 14 % , 11 % , and 23 % , respectively . The total peripheral resistance index increased by 21 % after 2 hours , and then reverted towards the pretreatment level . After 10 months of epanolol treatment ( mean 300 mg/day ) , the reduction in arterial pressure was 5 % at rest and 10 % during exercise . Cardiac index and heart rate were still reduced 14-21 % , while total peripheral resistance was unchanged or slightly increased ( 2-10 % ) . Twenty-four hour ambulatory blood pressure was higher on epanolol ( 300 mg/day ) than on atenolol ( 150 mg/day ) treatment ( 137/97 vs. 128/91 mmHg ) . Thus , the achieved blood pressure reduction induced by epanolol was moderate , while other characteristics of beta-receptor blockade , in particular , the reduction of heart rate and cardiac output , were maintained . This suggests that the compound may be useful for other cardiovascular disorders , e.g. , angina pectoris in patients without hypertension or cardiac arrhythmia .
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Intervention_Pharmacological
epanolol
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Intervention_Pharmacological
Epanolol
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Intervention_Pharmacological
epanolol
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Intervention_Pharmacological
epanolol
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Intervention_Pharmacological
atenolol
83963
Intervention_Pharmacological
epanolol
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Outcome_Physical
intraarterial pressure
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Outcome_Physical
Heart rate , stroke index , and cardiac index
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Outcome_Physical
total peripheral resistance index
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Outcome_Physical
arterial pressure
83968
Outcome_Physical
Cardiac index and heart rate
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Outcome_Physical
total peripheral resistance
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Outcome_Physical
Twenty-four hour ambulatory blood pressure
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate and cardiac output
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Participant_Condition
12 patients with essential hypertension .
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Participant_Condition
cardiovascular disorders
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Participant_Condition
hypertension
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Participant_Condition
cardiac arrhythmia