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document
[ The problems of prophylactic chemotherapy , the second-look operation and the maintenance of the remission in the treatment of ovarian cancer ( author 's transl ) ] . The results of the treatment of 1022 ovarian cancers were reviewed and the problems of prophylactic chemotherapy , a second look operation and the maintenance of the remission were studied . In ovarian cancers of stage 1 and stage 2 , a post-operative prophylactic chemotherapy is useful only in cases with tumor cells in the secretions of the pouch of Douglas or in the ascites and in cases where a sensitivity to the chemotherapy can be assumed . In about 50 % of primarily inoperable stage 3 ovarian cancers , the random treatment with cyclophosphamide ( Endoxan ) results in a clinical remission . A significant five year cure rate can only be obtained if the uterus and the adnexa are removed . Radical operation during the remission appears to be very important for survival of the patient . For the maintenance of the remission continuous chemotherapy for at least 2 years following treatment by operation and radiotherapy is necessary .
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Intervention_Pharmacological
prophylactic chemotherapy
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Intervention_Pharmacological
prophylactic chemotherapy
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Intervention_Pharmacological
post-operative prophylactic chemotherapy
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Intervention_Pharmacological
cyclophosphamide ( Endoxan )
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Intervention_Pharmacological
chemotherapy
11670
Intervention_Physical
radiotherapy
11671
Outcome_Physical
clinical remission
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Outcome_Other
cure
11673
Outcome_Mortality
rate
11674
Outcome_Mortality
survival
11675
Participant_Condition
1022 ovarian cancers
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Participant_Condition
ovarian cancers
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Participant_Condition
stage 1
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Participant_Condition
stage 2
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Participant_Condition
inoperable stage 3 ovarian cancers