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document
Impact of a fixed combination of clindamycin phosphate 1.2 % -benzoyl peroxide 2.5 % aqueous gel on health-related quality of life in moderate to severe acne vulgaris . The acne-specific quality of life ( Acne-QoL ) questionnaire was developed to measure the impact of facial acne across 4 domains ( acne symptoms , role-emotional , self-perception , role-social ) of health-related quality of life ( HRQL ) . This analysis assessed the impact of clindamycin phosphate 1.2 % -benzoyl peroxide 2.5 % ( clindamycin-BPO 2.5 % ) gel on HRQL in a combined study population ( N = 2813 ) of participants with moderate to severe acne vulgaris . Although the results presented within do not include factors of study and study-by-treatment interaction , analyses were performed to confirm that the results were consistent across the 2 identical , double-blind , randomized studies and within each treatment group across studies to justify pooling the data from both studies . The Acne-QoL questionnaire was administered at baseline and at the end of treatment ( week 12 ) . Treatment with clindamycin-BPO 2.5 % gel significantly improved participant-reported HRQL across all 4 domains compared with individual active ingredients and vehicle ( P < .001 ) . The percentage improvement in mean Acne-QoL domain scores with clindamycin-BPO 2.5 % gel ranged from 37 % to 59 % . Because the negative impact of facial acne on HRQL is one of the primary motivators for patients to seek treatment , this analysis underscores the importance of physicians incorporating assessments of HRQL into their clinical decision making .
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Intervention_Pharmacological
clindamycin phosphate 1.2 % -benzoyl peroxide 2.5 % aqueous gel
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Intervention_Pharmacological
clindamycin phosphate 1.2 % -benzoyl peroxide 2.5 % ( clindamycin-BPO 2.5 % ) gel
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Intervention_Pharmacological
clindamycin-BPO
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Intervention_Pharmacological
clindamycin-BPO
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Outcome_Other
Impact
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Outcome_Physical
measure the impact of facial acne
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Outcome_Physical
health-related quality of life ( HRQL ) .
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Outcome_Physical
Acne-QoL questionnaire
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Outcome_Physical
HRQL
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Outcome_Physical
mean Acne-QoL domain scores
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Outcome_Physical
HRQL
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Participant_Sample-size
2813
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Participant_Condition
moderate to severe acne vulgaris