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document
A double-blind randomized controlled trial of oral misoprostol and intramuscular syntometrine in the management of the third stage of labor . BACKGROUND The aim of this study was to compare the efficacy and safety of oral misoprostol 400 mug with intramuscular syntometrine in the management of the third stage of labor . MATERIAL AND METHODS This was a double-blind randomized controlled trial conducted in a tertiary care hospital . Three hundred and fifty-five women randomized to receive either oral misoprostol 400 mug or intramuscular syntometrine in the third stage of labor were studied . The change in hemoglobin level from before to 48 h after delivery , use of additional oxytocics and treatment related side effects were the main outcome measures . RESULTS There were no significant differences between the two groups in terms of the change in hemoglobin level and mean blood loss . The incidence of shivering was significantly higher in the misoprostol group whilst that of vomiting was significantly higher in the syntometrine group . There were no differences in the incidence of nausea , headache , diarrhea and pyrexia between the two groups . CONCLUSION Orally administered misoprostol at a dose of 400 mug is an acceptable alternative in preventing post-partum blood loss , as measured by the peri-partum change in hemoglobin level and was not associated with an increased incidence of side effects .
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Intervention_Pharmacological
misoprostol
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Intervention_Pharmacological
oral misoprostol 400 mug or intramuscular syntometrine
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Intervention_Pharmacological
misoprostol
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Intervention_Pharmacological
syntometrine
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Intervention_Pharmacological
misoprostol
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Outcome_Physical
hemoglobin level
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Outcome_Physical
hemoglobin level
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Outcome_Physical
mean blood loss
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Outcome_Physical
shivering
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Outcome_Adverse-effects
nausea , headache , diarrhea and pyrexia
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Outcome_Physical
blood loss
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Outcome_Physical
hemoglobin level
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Participant_Condition
third stage of labor
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Participant_Sample-size
Three hundred and fifty-five
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Participant_Sex
women
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Participant_Condition
third stage of labor