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document
Prospective trial of intraoperative mitomycin C in the treatment of primary pterygium . AIMS A prospective , randomised , double blind , placebo controlled study of intraoperative mitomycin C as adjunctive treatment of primary pterygium was conducted . METHODS A total of 66 eyes of 54 patients with primary pterygium were treated with excision , with or without a single intraoperative application of mitomycin C ( 0.1 mg/ml for 5 minutes ) to evaluate the efficacy and toxicity of this adjunctive treatment . The mean follow up was 14.1 months ( range 12-23 months ) . RESULTS Of the 36 eyes that underwent simple excision , 14 ( 38.8 % ) exhibited recurrences whereas only one of 30 eyes ( 3.33 % ) treated with excision and intraoperative application of mitomycin C had recurrence ( p = 0.0006 ) . Neither serious ocular complications nor systemic toxicity were noted in the mitomycin C treated group . CONCLUSION Intraoperative mitomycin C appears to be an effective and safe adjunctive treatment of primary pterygium .
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Intervention_Pharmacological
intraoperative mitomycin C
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Intervention_Control
placebo
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Intervention_Pharmacological
intraoperative mitomycin C
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Intervention_Pharmacological
excision , with or without a single intraoperative application of mitomycin C
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Intervention_Pharmacological
mitomycin C
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Intervention_Pharmacological
mitomycin C
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Intervention_Pharmacological
mitomycin C
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Outcome_Other
efficacy and toxicity
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Outcome_Physical
recurrences
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Outcome_Physical
recurrence
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Outcome_Adverse-effects
ocular complications nor systemic toxicity
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Participant_Condition
primary pterygium
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Participant_Sample-size
54