48356
document
The effect of HCG supplementation after combined GnRH agonist/HMG treatment in an IVF programme . The necessity of luteal-phase supplementation in an IVF programme is of continuing interest . After ovarian stimulation with clomiphene and human menopausal gonadotrophin ( HMG ) , the beneficial effect of supporting the luteal phase has never been scientifically demonstrated . After ovarian stimulation with GnRH agonist/HMG , the luteal phase seems to be inadequate , but in a previous study we did not find evidence to support the need for oral progesterone supplementation . To evaluate the beneficial effect of human chorionic gonadotrophin ( HCG ) supplementation , we performed a multicentre , double-blind , randomized study with HCG ( 193 transfers ) against placebo ( 194 transfers ) . The ongoing pregnancy rate per transfer cycle was significantly better with HCG ( 18.7 versus 9.3 ) . This is the first truly objective ( randomized ) study demonstrating the beneficial effect of supporting the luteal phase in an IVF programme .
48357
Intervention_Physical
HCG supplementation
48358
Intervention_Pharmacological
combined GnRH agonist/HMG treatment
48359
Intervention_Physical
luteal-phase supplementation
48360
Intervention_Pharmacological
human menopausal gonadotrophin ( HMG )
48361
Intervention_Pharmacological
GnRH agonist/HMG
48362
Intervention_Physical
human chorionic gonadotrophin ( HCG ) supplementation
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Intervention_Pharmacological
HCG
48364
Intervention_Control
placebo
48365
Intervention_Physical
HCG
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Outcome_Physical
ongoing pregnancy rate per transfer cycle
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Participant_Condition
treatment in an IVF programme .
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Participant_Condition
IVF programme .