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document
Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas : long-term results of a Japanese multicenter randomized controlled trial . BACKGROUND The value of pancreatoduodenectomy ( PD ) with extended lymphadenectomy for pancreatic cancer has been evaluated by many retrospective studies and 3 randomized controlled trials ( RCT ) . However , the protocols used and the results found in the 3 RCTs were diverse . Therefore , a multicenter RCT was proposed in 1998 to evaluate the primary end point of long-term survival and the secondary end points of morbidity , mortality and quality of life of patients undergoing standard versus extended lymphadenectomy in radical PD for pancreatic cancer . METHODS From March 2000 to May 2003 , 112 patients with potentially curable pancreatic head cancer were enrolled and intraoperatively randomized to a standard or extended lymphadenectomy group . No resected patients received any adjuvant treatments . RESULTS A hundred and one eligible patients were analyzed . Demographic and histopathological characteristics of the two groups were similar . The mean operating time , intraoperative blood loss and number of retrieved lymph nodes were greater in the extended group , but the other operative results were comparable . CONCLUSIONS Although this multicenter RCT was conducted in a strict setting , extended lymphadenectomy in radical PD did not benefit long-term survival in patients with resectable pancreatic head cancer and led to levels of morbidity , mortality and quality of life comparable to those found after standard lymphadenectomy .
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Intervention_Surgical
extended lymphadenectomy
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Intervention_Surgical
extended lymphadenectomy
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Intervention_Surgical
standard or extended lymphadenectomy
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Intervention_Surgical
extended lymphadenectomy
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Intervention_Surgical
standard lymphadenectomy .
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Outcome_Other
mean operating time
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Outcome_Physical
intraoperative blood loss
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Outcome_Physical
number of retrieved lymph nodes
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Participant_Condition
radical PD
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Participant_Condition
pancreatic cancer
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Participant_Sample-size
112
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Participant_Condition
pancreatic head cancer
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Participant_Sample-size
A hundred and one
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Participant_Condition
resectable pancreatic head cancer