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document
High-dose pyridoxine and magnesium administration in children with autistic disorder : an absence of salutary effects in a double-blind , placebo-controlled study . Several reports have described salutary effects such as decreased physical aggression and improved social responsiveness being associated with the administration of high doses of pyridoxine and magnesium ( HDPM ) in open-labeled and controlled studies of patients with autism . Despite this fact , this intervention remains controversial . A 10-week double-blind , placebo-controlled trial was undertaken to examine both the efficacy and safety of HDPM in autism . Twelve patients were enrolled , and 10 patients ( mean age 6 years 3 months ) were able to complete the study . HDPM at an average dose of 638.9 mg of pyridoxine and 216.3 mg of magnesium oxide was ineffective in ameliorating autistic behaviors as assessed by the Children 's Psychiatric Rating Scale ( CPRS ) , the Clinical Global Impression Scale , and the NIMH Global Obsessive Compulsive Scale . Furthermore , no clinically significant side effects were noted during HDPM administration . A trend for a transient change on the CPRS was found that was possibly due to a placebo response . This study raises doubts about the clinical effectiveness of HDPM in autistic disorder .
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Intervention_Pharmacological
High-dose pyridoxine and magnesium administration
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Intervention_Pharmacological
pyridoxine and magnesium ( HDPM )
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Intervention_Pharmacological
HDPM
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Intervention_Pharmacological
HDPM
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Intervention_Pharmacological
pyridoxine
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Intervention_Pharmacological
magnesium oxide
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Intervention_Pharmacological
HDPM
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Intervention_Pharmacological
HDPM
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Outcome_Mental
ameliorating autistic behaviors
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Outcome_Mental
Children 's Psychiatric Rating Scale ( CPRS )
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Outcome_Mental
the Clinical Global Impression Scale
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Outcome_Mental
NIMH Global Obsessive Compulsive Scale
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Participant_Age
children
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Participant_Condition
autistic disorder
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Participant_Condition
autism
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Participant_Sample-size
Twelve
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Participant_Sample-size
10
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Participant_Age
6 years 3 months