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document
[ Clinical effect of transcatheter arterial chemoembolization combined with high intensity focused ultrasound ablation in treatment of large hepatocellular carcinoma ] . OBJECTIVE To investigate the clinical effect of transcatheter arterial chemoembolization ( TACE ) combined with high intensity focused ultrasound ( HIFU ) ablation in treatment of large hepatocellular carcinoma ( HCC ) . METHODS Sixty-eight patients with unresectable HCC were randomized into 2 age , tumor size , TNM stages , and liver function grade-matched groups : TACE group ( n=30 ) undergoing TACE and TACE+HIFU group ( n=38 ) undergoing 2-3 weeks after TACE . A total of 88 tumors ( 9.3+/-3.2 ) ( 5.0-14.5 ) cm in diameter were detected , and the largest tumor in a specific patients with multiple lesions was selected for observation . Follow-up was conducted for ( 13+/-7 ) ( 3-24 ) months to observe the necrosis of tumor , size of tumor , local recurrence , and survival of patient . RESULTS The clinical symptom remission rate was 90.6 % ( 29/32 ) in the TACE+HIFU group and 70.8 % ( 28/38 ) in the TACE group . The tumor necrosis and minification rates of the TACE+HIFU and TACE groups were 73.7 % and 68.4 % respectively , both significantly higher than those of TACE group ( 26.7 % and 33.3 % respectively , both P < 0.01 ) . The tumor local recurrence rate of the TACE+HIFU group was 21.1 % , not significantly different from that of the TACE group ( 33.3 % , P > 0.05 ) . The median survival duration of the TACE+HIFU group was 18 months , significantly longer than that of the TACE group ( 10 months , P < 0.05 ) . CONCLUSION Compared with the TACE therapy alone , the combination therapy improves the tumor necrosis rate and prolongs the patients ' survival duration .
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Intervention_Surgical
transcatheter arterial chemoembolization
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Intervention_Surgical
high intensity focused ultrasound ablation
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Intervention_Surgical
transcatheter arterial chemoembolization ( TACE )
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Intervention_Surgical
high intensity focused ultrasound ( HIFU )
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Intervention_Physical
2 age , tumor size , TNM stages
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Intervention_Physical
liver function grade-matched groups
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Intervention_Surgical
TACE
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Intervention_Physical
group ( n=30 ) undergoing
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Intervention_Surgical
TACE
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Intervention_Surgical
TACE+HIFU
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Intervention_Physical
group ( n=38 ) undergoing 2-3 weeks after TACE
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Intervention_Surgical
TACE+HIFU
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Intervention_Surgical
TACE+HIFU
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Intervention_Surgical
TACE
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Intervention_Surgical
TACE
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Intervention_Surgical
TACE+HIFU
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Intervention_Surgical
TACE
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Intervention_Surgical
TACE+HIFU
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Intervention_Surgical
TACE
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Intervention_Surgical
TACE
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Outcome_Physical
necrosis of tumor , size of tumor , local recurrence
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Outcome_Mortality
survival of patient .
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Outcome_Physical
clinical symptom remission rate
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Outcome_Physical
tumor necrosis
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Outcome_Physical
minification rates
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Outcome_Physical
tumor local recurrence rate
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Outcome_Mortality
median survival duration
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Outcome_Physical
tumor necrosis rate
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Outcome_Mortality
patients ' survival duration
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Participant_Condition
large hepatocellular carcinoma ]
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Participant_Condition
hepatocellular carcinoma ( HCC ) .
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Participant_Sample-size
Sixty-eight
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Participant_Condition
patients with multiple lesions