88253
document
Relationship of the dose of intravenous gammaglobulin to the prevention of infections in adults with common variable immunodeficiency . The objective was to assess clinical efficacy of 3 dosages of intravenous gammaglobulins to prevent infectious episodes in adult common variable immunodeficiency . We designed a randomized , double blind , dose-assessing study . The setting was at University Hospital , Out-patient Clinic . Our patients were twenty-one adult patients with common variable immunodeficiency . The measurements were comparative study of the number and severity of infections using 3 various dosages of intravenous gammaglobulins , each given monthly for M least 6 months . Results indicated four hundred and eighty-four infectious episodes occurred while giving 305 infusions of IVIG 200 mg/kg ; 205 infectious episodes while giving 170 infusions of 400 mg/kg and 436 infectious episodes while giving 247 infusions of 600 mg/kg . The morbidity scores ( infection/infusion ) were 1.59 , 1.21 and 1.77 respectively ( p - N/S ) . There was no significant difference in the severity of infections on the above 3 dosages , and no difference in the duration of infection-free intervals . The conclusions resulted in no significant differences in morbidity in adult patients with common variable immunodeficiency treated in cross-over pattern with IVIG 200 mg/kg , 400 mg/kg and 600 mg/kg . Thus , high dosages of IVIG are not conferring better protection against infections in such patients .
88254
Intervention_Pharmacological
gammaglobulin
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Intervention_Pharmacological
intravenous gammaglobulins
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Intervention_Pharmacological
gammaglobulins
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Intervention_Pharmacological
IVIG 200 mg/kg
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Outcome_Physical
number and severity of infections
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Outcome_Physical
infectious episodes
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Outcome_Mortality
morbidity scores ( infection/infusion )
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Outcome_Physical
severity of infections
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Outcome_Physical
duration of infection-free intervals
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Outcome_Mortality
morbidity
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Participant_Condition
immunodeficiency
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Participant_Condition
The setting was at University Hospital , Out-patient Clinic .
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Participant_Sample-size
twenty-one