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document
Treatment of stable angina of effort with verapamil : a double-blind , placebo-controlled randomized crossover study . The effects of verapamil were assessed in 26 patients with stable exertional angina pectoris in a double-blind , placebo-controlled , randomized crossover protocol using serial treadmill tests . Verapamil , 480 mg/day , reduced anginal frequency from 5.6 +/- 7.3 to 2.2 +/- 3.9 attacks per week ( p less than 0.001 ) and nitroglycerin consumption from 3.4 +/- 4.9 to 1.2 +/- 2.5 tablets per week ( p less than 0.05 ) compared with placebo . Treadmill time increased from 6.4 +/- 2.1 minutes during the placebo phase to 7.5 +/- 1.8 minutes during the verapamil phase ( p less than 0.001 ) . Verapamil 's beneficial effect appeared to be related , in part , to a 10 % reduction of the rate-pressure product at rest ( p less than 0.05 ) and a 12 % reduction during submaximal exercise ( p less than 0.001 ) . Verapamil also caused less marked ST-segment depressions at peak exercise ( p less than 0.05 ) at a similar rate-pressure product , suggesting a favorable redistribution of coronary blood flow to the ischemic zone . Side effects from verapamil were minimal , consisting mainly of constipation ( six patients ) . Verapamil appears to be a safe and effective drug for treating angina of effort .
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Intervention_Pharmacological
verapamil
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
verapamil
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Intervention_Pharmacological
Verapamil
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Intervention_Pharmacological
nitroglycerin
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
verapamil
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Intervention_Pharmacological
Verapamil 's
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Intervention_Pharmacological
Verapamil
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Intervention_Pharmacological
verapamil
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Intervention_Pharmacological
Verapamil
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Outcome_Physical
anginal frequency
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Outcome_Other
nitroglycerin consumption
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Outcome_Physical
Treadmill time
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Outcome_Physical
rate-pressure product
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Outcome_Physical
ST-segment depressions at peak exercise
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Outcome_Physical
coronary blood flow
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Outcome_Adverse-effects
constipation
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Outcome_Other
safe and effective
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Participant_Condition
stable angina of effort
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Participant_Condition
angina