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Successful treatment of blepharitis with bibrocathol ( Posiformin® 2 % ) . BACKGROUND Bibrocathol is a well-established antiseptic drug for the treatment of acute eyelid diseases like blepharitis . Despite its frequent use in clinical practice , no controlled clinical trial on the efficacy of bibrocathol 2 % eye ointment has been performed until now . The aim of the study was to investigate efficacy , safety and tolerability of bibrocathol ( Posiformin® 2 % ) eye ointment in patients diagnosed with blepharitis . METHODS In this multi-center , randomized , double-masked , placebo-controlled parallel-group comparison , the change of signs and symptoms ( sum score ) of blepharitis in 197 patients ( ITT ( intention-to-treat-group ) ; mean age 56 ± 18 years , 56 % female , active drug : vehicle = 97:100 ) over 2 weeks treatment with bibrocathol 2 % eye ointment was evaluated . RESULTS Patients receiving bibrocathol 2 % showed greater improvement in the sum score than the placebo patients ( p < 0.0001 , Cohen 's effect size d = 0.73 ) . Also , the results from further efficacy assessments improvement of single symptoms and ocular discomfort measured by a VAS ( visual analogue scale ) supported treatment with bibrocathol . Patients and investigators provided favorable tolerability ratings preferring bibrocathol over placebo . No safety issues were observed with regard to intraocular pressure , visual acuity , or occurrence of adverse events . CONCLUSIONS Blepharitis therapy with the antiseptic bibrocathol 2 % in this trial was highly efficacious and safe .
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Intervention_Pharmacological
bibrocathol ( Posiformin® 2 % )
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Intervention_Pharmacological
Bibrocathol
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Intervention_Pharmacological
bibrocathol 2 %
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Intervention_Pharmacological
bibrocathol ( Posiformin®
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Intervention_Pharmacological
antiseptic
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Outcome_Mental
single symptoms
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Outcome_Mental
discomfort
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Outcome_Physical
intraocular pressure , visual acuity ,
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Participant_Condition
blepharitis