37695
document
Impact of isotonic and hypertonic saline solutions on mucociliary activity in various nasal pathologies : clinical study . OBJECTIVE To investigate the impact of nasal irrigation with isotonic or hypertonic sodium chloride solution on mucociliary clearance time in patients with allergic rhinitis , acute sinusitis and chronic sinusitis . PATIENTS AND METHODS Mucociliary clearance time was measured using the saccharine clearance test on 132 adults before and after 10 days ' application of intranasal isotonic or hypertonic saline . Patient numbers were as follows : controls , 45 ; allergic rhinitis , 21 ; acute sinusitis , 24 ; and chronic sinusitis , 42 . The results before and after irrigation were compared using the Wilcoxon t-test . RESULTS Before application of saline solutions , mucociliary clearance times in the three patient treatment groups were found to be significantly delayed , compared with the control group . Irrigation with hypertonic saline restored impaired mucociliary clearance in chronic sinusitis patients ( p < 0.05 ) , while isotonic saline improved mucociliary clearance times significantly in allergic rhinitis and acute sinusitis patients ( p < 0.05 ) . CONCLUSION Nasal irrigation with isotonic or hypertonic saline can improve mucociliary clearance time in various nasal pathologies . However , these solutions should be selectively prescribed rather than used based on anecdotal evidence . Further studies should be conducted to develop a protocol for standardised use of saline solution irrigation in various nasal pathologies .
37696
Intervention_Pharmacological
isotonic
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Intervention_Pharmacological
hypertonic saline solutions
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Intervention_Pharmacological
isotonic
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Intervention_Pharmacological
hypertonic sodium chloride solution
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Intervention_Pharmacological
application of intranasal isotonic
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Intervention_Pharmacological
hypertonic saline
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Intervention_Pharmacological
saline solutions
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Intervention_Pharmacological
hypertonic saline
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Intervention_Pharmacological
isotonic saline
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Intervention_Pharmacological
isotonic
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Intervention_Pharmacological
hypertonic saline
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Intervention_Pharmacological
saline solution irrigation
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Outcome_Physical
mucociliary clearance times
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Outcome_Physical
restored impaired mucociliary clearance in chronic sinusitis patients
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Outcome_Physical
improved mucociliary clearance times significantly
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Outcome_Physical
mucociliary clearance time
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Participant_Condition
nasal pathologies
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Participant_Condition
allergic rhinitis
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Participant_Condition
acute sinusitis
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Participant_Condition
chronic sinusitis
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Participant_Sample-size
132
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Participant_Age
adults
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Participant_Sample-size
controls , 45
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Participant_Sample-size
allergic rhinitis , 21
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Participant_Sample-size
acute sinusitis , 24
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Participant_Sample-size
chronic sinusitis , 42