18795
document
Absorption of intramuscular phenobarbitone in children with severe falciparum malaria . The absorption of intramuscular phenobarbitone 7 mg.kg-1 was studied in 11 Karen children aged between 1.7 and 11 y with severe falciparum malaria . Eight of the children were comatose . Clinical findings were compared with those in 9 further children with severe malaria of similar age range ( four of whom were unconscious ) , who received an identical placebo . One child , who had received placebo , had repeated convulsions and died 1 h after admission to hospital . The remainder made an uncomplicated recovery . There were no convulsions subsequent to treatment , although the study was too small to assess anticonvulsant efficacy . There was no observable toxicity , but phenobarbitone recipients had a significant tendency to deepen in their level of coma or to become sleepy within the 4 h after drug administration . Phenobarbitone was rapidly absorbed , reaching a mean ( range ) peak concentration of 34.2 [ 29.3-42.6 ] mumol.l-1 in a median ( range ) of 4 ( 2.5-12 ) h. These values are comparable to those previously reported in healthy children and in children with febrile convulsions . Intramuscular phenobarbitone is well absorbed in children with severe malaria ; the optimum prophylactic anticonvulsant dose remains to be determined .
18796
Intervention_Pharmacological
intramuscular phenobarbitone 7 mg.kg-1
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Intervention_Control
identical placebo .
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Outcome_Other
Absorption of intramuscular phenobarbitone
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Outcome_Other
absorption of intramuscular phenobarbitone
18800
Outcome_Physical
repeated convulsions
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Outcome_Physical
uncomplicated recovery .
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Outcome_Physical
convulsions
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Outcome_Other
toxicity
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Outcome_Physical
level of coma
18805
Outcome_Physical
become sleepy
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Outcome_Physical
febrile convulsions
18807
Participant_Age
children
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Participant_Condition
falciparum malaria
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Participant_Sample-size
11
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Participant_Condition
Karen
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Participant_Age
between 1.7 and 11 y
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Participant_Condition
falciparum malaria
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Participant_Sample-size
Eight