36653
document
Less tachycardia in adults when using atropine 0.9 mg compared with 1.2 mg plus neostigmine 2.5 mg . OBJECTIVE Compare the increase in heart rate in adults after 0.9 vs. 1.2 mg of atropine plus neostigmine 2.5 mg as the non-depolarizing muscle relaxant reversal agent . MATERIAL AND METHOD A randomized , double blind , controlled trial on 46 adults ASA I-II , undergoing elective gynecological or general surgery with balanced general anesthesia was performed . The subjects were randomized into two groups , After surgery , the study group received 0.9 mg of atropine , while the control group received 1.2 mg of atropine . Both groups received 2.5 mg of neostigmine simultaneously . RESULTS The heart rate and blood pressure were taken at 0 , 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 15 , 20 , 25 , and 30 min after the injection . The increase in heart rate and blood pressure between the two groups were compared . The heart rate ( at 3 , 4 , 5 , and 6 min ) of patients in the study group increased significantly less than that of patients in the control group . There was no significant difference in blood pressure between groups and no side effects occurred . CONCLUSION The authors conclude that 0.9 mg of atropine with 2.5 mg neostigmine can be safely used as the reversal agent for a non-depolarizing muscle relaxant , particularly in patients for whom any increase in heart rate would be harmful .
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Intervention_Pharmacological
atropine
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Intervention_Pharmacological
neostigmine
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Intervention_Pharmacological
atropine
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Intervention_Physical
plus
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Intervention_Pharmacological
neostigmine
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Intervention_Pharmacological
0.9 mg of atropine
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Intervention_Control
control
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Intervention_Pharmacological
1.2 mg of atropine
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Intervention_Pharmacological
2.5 mg of neostigmine
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Intervention_Pharmacological
atropine
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Intervention_Pharmacological
neostigmine
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Outcome_Physical
tachycardia
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Outcome_Physical
heart rate
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Outcome_Physical
heart rate
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate