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document
Granulocyte-macrophage colony-stimulating factor as immunomodulating factor together with influenza vaccination in stem cell transplant patients . The effect of granulocyte-macrophage colony-stimulating factor ( GM-CSF ) on the serological response at influenza vaccination was studied in 117 patients who had undergone stem cell transplantation ( SCT ) . The vaccine response was evaluated as significant increases in levels of influenza hemagglutination-inhibition ( HAI ) antibodies and of IgG antibodies measured by enzyme-linked immunosorbent assay ( ELISA ) . There was no difference in antibody response to either influenza A or B in 64 patients who received GM-CSF at vaccination , compared with the 53 who did not . In the subgroup of allogeneic SCT patients , HAI showed that the response rate to the influenza B vaccine was significantly higher in the treatment group ( P < .05 ) . ELISA showed that autologous SCT patients with breast cancer who received GM-CSF had a better response to influenza A ( P < .05 ) and B ( P < .01 ) . At early vaccination , 4-12 months after stem cell transplantation , these responses were more pronounced . GM-CSF appears to improve the response to influenza vaccination in some groups of SCT patients , but only to a limited extent .
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Intervention_Pharmacological
Granulocyte-macrophage colony-stimulating factor
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Intervention_Pharmacological
influenza vaccination
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Intervention_Physical
granulocyte-macrophage colony-stimulating factor ( GM-CSF )
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Intervention_Pharmacological
influenza vaccination
2676
Intervention_Physical
GM-CSF
2677
Intervention_Pharmacological
influenza B vaccine
2678
Intervention_Pharmacological
GM-CSF
2679
Outcome_Physical
serological response
2680
Outcome_Physical
vaccine response
2681
Outcome_Physical
levels of influenza hemagglutination-inhibition ( HAI ) antibodies
2682
Outcome_Physical
IgG antibodies
2683
Outcome_Physical
antibody response
2684
Outcome_Physical
ELISA
2685
Outcome_Physical
influenza A
2686
Outcome_Other
influenza vaccination
2687
Participant_Condition
stem cell transplant
2688
Participant_Sample-size
117
2689
Participant_Condition
undergone stem cell transplantation
2690
Participant_Condition
SCT
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Participant_Condition
SCT patients