46829
document
A comparison of the effect of short-term aromatase inhibitor ( letrozole ) and GnRH agonist ( triptorelin ) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis . PURPOSE To compare the role of an aromatase inhibitor ( letrozole ) with a GnRH agonist ( triptorelin ) versus case control on the pregnancy rate and recurrence of symptoms and signs in patients with endometriosis . METHODS In a prospective randomized clinical trial , after treatment of 144 infertile women in their reproductive age by laparoscopy ( whose endometriosis was confirmed by prior laparoscopy ) , they were divided into 3 groups : group 1 ( 47 cases ) who received letrozole for 2 months , group 2 ( 40 patients ) who were prescribed triptorelin for 2 months and group 3 who were 57 patients in the control group and did not receive any medication . We followed up each group at least for 12 months after their restoration of regular cycle . RESULTS Pregnancy rate was 23.4 % in group 1 , 27.5 % in group 2 , and 28.1 % in group 3 . The results did not show significant differences among the 3 groups . Recurrence rate of endometriosis was 6.4 % in group 1 , 5 % group 2 and 5.3 % in group 3 , which was not statistically significantly different as well . CONCLUSION Pregnancy rate and endometriosis recurrence rate are comparable among the 3 groups .
46830
Intervention_Pharmacological
aromatase inhibitor ( letrozole )
46831
Intervention_Pharmacological
GnRH agonist ( triptorelin )
46832
Intervention_Pharmacological
aromatase inhibitor ( letrozole )
46833
Intervention_Pharmacological
GnRH agonist ( triptorelin )
46834
Intervention_Surgical
laparoscopy
46835
Intervention_Physical
endometriosis
46836
Intervention_Surgical
laparoscopy
46837
Intervention_Pharmacological
letrozole
46838
Intervention_Pharmacological
triptorelin
46839
Intervention_Control
control
46840
Intervention_Control
did not receive any medication
46841
Outcome_Physical
pregnancy rate
46842
Outcome_Physical
symptom and sign recurrence
46843
Outcome_Physical
pregnancy rate
46844
Outcome_Physical
recurrence of symptoms and signs
46845
Outcome_Physical
Pregnancy rate
46846
Outcome_Other
did not show significant differences
46847
Outcome_Physical
Recurrence rate of endometriosis
46848
Outcome_Other
not statistically significantly different
46849
Outcome_Physical
Pregnancy rate
46850
Outcome_Physical
endometriosis recurrence rate
46851
Participant_Condition
endometriosis
46852
Participant_Sample-size
144
46853
Participant_Condition
infertile
46854
Participant_Sex
women
46855
Participant_Sample-size
47