43792
document
Paracetamol reduces postoperative pain and rescue analgesic demand after robot-assisted endoscopic thyroidectomy by the transaxillary approach . BACKGROUND Postoperative pain following endoscopic thyroidectomy , although less severe than after open methods , is still a source of marked discomfort and surgical stress . This clinical trial was conducted to determine if repeated intravenous paracetamol could decrease postoperative pain and rescue analgesic requirements after robot-assisted endoscopic thyroidectomy via the transaxillary approach . MATERIALS AND METHODS This prospective , randomized , double-blinded , and placebo-controlled study enrolled 124 women 21-60 years of age who were scheduled for elective gasless robot-assisted endoscopic thyroidectomy via the transaxillary approach . The patients were given placebo or 1 g of paracetamol as a 100 ml solution infused over 15 min 1 h before the induction of anesthesia , and then at 6-h intervals for the following 24 h. RESULTS Postoperative pain scores were significantly lower at 1 , 3 , 6 , and 24 h after surgery in the paracetamol group than in the placebo group . Significantly fewer patients in the paracetamol group received rescue analgesics compared to the placebo group ( 9.5 % vs. 65.6 % , respectively ) . First analgesic time was similar in the two groups . Postoperative nausea ( 44.3 % vs. 22.2 % ) and vomiting ( 21.3 % vs. 6.3 % ) were more frequent in the placebo group than in the paracetamol group . Other postoperative side effects , including sedation , confusion , and pruritus , were similar in the two groups . CONCLUSIONS We concluded that repeated administration of 1 g of intravenous paracetamol over 24 h is easy , effective , safe , and well tolerated for pain management in patients with moderate to severe postoperative pain after gasless robot-assisted endoscopic thyroidectomy performed via the transaxillary approach .
43793
Intervention_Pharmacological
Paracetamol
43794
Intervention_Pharmacological
rescue analgesic
43795
Intervention_Surgical
robot-assisted endoscopic thyroidectomy by the transaxillary approach
43796
Intervention_Surgical
endoscopic thyroidectomy
43797
Intervention_Pharmacological
intravenous paracetamol
43798
Intervention_Surgical
robot-assisted endoscopic thyroidectomy
43799
Intervention_Physical
transaxillary approach
43800
Intervention_Control
placebo-controlled
43801
Intervention_Surgical
elective gasless robot-assisted endoscopic thyroidectomy
43802
Intervention_Physical
transaxillary approach
43803
Intervention_Control
placebo
43804
Intervention_Pharmacological
paracetamol
43805
Intervention_Pharmacological
anesthesia
43806
Intervention_Pharmacological
paracetamol
43807
Intervention_Control
placebo
43808
Intervention_Pharmacological
paracetamol
43809
Intervention_Pharmacological
rescue analgesics
43810
Intervention_Control
placebo
43811
Intervention_Pharmacological
analgesic
43812
Intervention_Control
placebo
43813
Intervention_Pharmacological
paracetamol
43814
Intervention_Pharmacological
intravenous paracetamol
43815
Intervention_Physical
gasless robot-assisted endoscopic thyroidectomy
43816
Intervention_Physical
transaxillary approach
43817
Outcome_Pain
pain and rescue analgesic demand
43818
Outcome_Pain
Postoperative pain scores
43819
Outcome_Pain
analgesic time
43820
Outcome_Adverse-effects
Postoperative nausea
43821
Outcome_Adverse-effects
vomiting
43822
Outcome_Adverse-effects
sedation , confusion , and pruritus
43823
Participant_Condition
Postoperative pain following endoscopic thyroidectomy
43824
Participant_Sample-size
124 women
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Participant_Condition
moderate to severe postoperative pain