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document
Heparin plus dipyridamole in childhood hemolytic-uremic syndrome : a prospective , randomized study . From 1976 to 1985 , a total of 58 infants and children with the hemolytic-uremic syndrome were randomly assigned to treatment either with heparin and dipyridamole or with supportive management only . In the treatment group , two patients died in the early weeks of the disease . Analysis of clinical and laboratory data showed no significant difference between either group of patients as to the evolution of their illness except for a significantly higher incidence of anuria and a significantly faster recovery from hypertension in the treated group . Renal biopsy studies showed no differences between the two groups in terms of incidence and severity of the histologic lesions . The long-term data on blood pressure and creatinine clearance values in the survivors were similar in both groups . This study indicates that treatment with heparin and dipyridamole has no benefit over symptomatic therapy alone in the typical form of childhood hemolytic-uremic syndrome .
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Intervention_Pharmacological
Heparin plus dipyridamole
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Intervention_Pharmacological
heparin and dipyridamole
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Intervention_Pharmacological
heparin
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Intervention_Pharmacological
dipyridamole
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Intervention_Physical
symptomatic therapy
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Outcome_Physical
incidence of anuria
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Outcome_Physical
faster recovery from hypertension
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Outcome_Physical
incidence and severity of the histologic lesions
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Outcome_Physical
blood pressure
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Outcome_Physical
creatinine clearance values
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Outcome_Physical
heparin
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Outcome_Physical
dipyridamole
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Outcome_Other
benefit over symptomatic therapy
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Participant_Age
childhood
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Participant_Sample-size
58
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Participant_Age
infants and children
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Participant_Condition
hemolytic-uremic syndrome