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document
The effect of pain-free treadmill training on fibrinogen , haematocrit , and lipid profile in patients with claudication . OBJECTIVE To assess the effect of pain-free treadmill training on changes of plasma fibrinogen , haematocrit , lipid profile , and walking ability in patients with claudication . DESIGN Randomized control trial . METHODS Sixty-eight patients with peripheral obstructive arterial disease and intermittent claudication ( Fontaine stage II ) were randomly assigned into the treadmill training ( repetitive intervals to onset of claudication pain , three times a week ) or a control group ( no change in physical activity ) over 3 months . Both groups performed treadmill test to assess pain-free walking time ( PFWT ) and maximal walking time ( MWT ) and had blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ] done at baseline and after 6 and 12 weeks of the study . RESULTS Total and LDL cholesterol levels in the training group decreased ( p < 0.05 ) by 14.8 % and 20,5 % , respectively . Significant ( p < 0.05 ) HDL cholesterol increased ( 14.6 % ) and triglycerides decreased ( 19 % ) in the training group but changes of all these lipids were insignificant in the control group over the 3 months . Haematocrit and fibrinogen changes were insignificant in both groups . PFWT was prolonged by 109 % and MWT increased by 54 % in the training group ( p < 0.01 ) , but not in the control group . CONCLUSION The improvement in walking time over 3 months of pain-free treadmill training parallels with progressive normalization of lipid profiles in patients with claudication .
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Intervention_Physical
pain-free treadmill training
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Intervention_Physical
pain-free treadmill training
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Intervention_Physical
treadmill training
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Intervention_Control
control group
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Intervention_Physical
no change in physical activity
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Intervention_Physical
treadmill
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Outcome_Physical
plasma fibrinogen , haematocrit , lipid profile , and walking ability
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Outcome_Physical
pain-free walking time ( PFWT )
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Outcome_Physical
maximal walking time ( MWT )
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Outcome_Physical
blood analyses [ for haematocrit , fibrinogen , triglycerides , and cholesterol : total , high-density lipoprotein ( HDL ) and low-density lipoprotein ( LDL ) ]
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Outcome_Physical
Total and LDL cholesterol levels
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Outcome_Physical
HDL cholesterol
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Outcome_Physical
triglycerides
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Outcome_Physical
Haematocrit
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Outcome_Physical
fibrinogen
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Participant_Condition
claudication
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Participant_Sample-size
Sixty-eight
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Participant_Condition
peripheral obstructive arterial disease
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Participant_Condition
intermittent claudication