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document
Hepatectomy Versus Hepatectomy With Lymphadenectomy in Hepatocellular Carcinoma : A Prospective , Randomized Controlled Clinical Trial . GOALS AND BACKGROUND The role of preventive lymphadenectomy has not yet been determined for hepatocellular carcinoma ( HCC ) patients . We designed a study to evaluate the effect of hepatectomy combined with preventive lymphadenectomy on HCC patients . STUDY Patients were randomly divided into group A ( treated with hepatectomy alone ) and group B ( underwent hepatectomy combined with lymphadenectomy ) . The postoperative complications and oncologic prognoses were analyzed . RESULTS Of the 85 patients enrolled into this study , 79 cases ( 38 in group A and 41 in group B ) were pathologically confirmed to have HCC and received curative resection . One hundred and sixteen lymph nodes were dissected and evaluated as negative by the pathologist . The 12- , 36- , and 60-month disease-free survival rates of group A were 81.6 % , 68.4 % , and 63.2 % , respectively , whereas they were 78.0 % , 65.9 % , and 63.4 % , respectively , for group B . The 12- , 36- , and 60-month overall survival rates in group A were 94.7 % , 78.9 % , and 65.8 % , respectively , whereas they were 87.8 % , 78.0 % , and 70.7 % , respectively , in group B . The differences in the disease-free survival and overall survival between the 2 groups were not statistically significant according to the log-rank test ( P=0.811 and P=0.881 , respectively ) . The difference in the surgical complication rate between groups A and B was not statistically significant ( 47.4 % vs. 36.6 % , P=0.332 ) . CONCLUSIONS Although hepatectomy combined with regional lymphadenectomy is a safe procedure , preventive lymphadenectomy may not decrease the rate of tumor recurrence nor improve the prognosis in early-stage HCC patients .
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Intervention_Physical
Hepatectomy Versus Hepatectomy With Lymphadenectomy
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Intervention_Physical
hepatectomy combined with preventive lymphadenectomy
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Intervention_Physical
( treated with hepatectomy alone )
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Intervention_Physical
( underwent hepatectomy combined with lymphadenectomy )
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Intervention_Physical
hepatectomy combined with regional lymphadenectomy
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Outcome_Physical
oncologic prognoses
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Outcome_Mortality
disease-free survival rates
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Outcome_Mortality
overall survival rates
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Outcome_Mortality
disease-free survival
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Outcome_Mortality
overall survival
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Outcome_Adverse-effects
surgical complication rate
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Outcome_Adverse-effects
recurrence
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Outcome_Mental
prognosis
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Participant_Condition
hepatocellular carcinoma ( HCC ) patients .
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Participant_Condition
HCC
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Participant_Sample-size
85
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Participant_Sample-size
79
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Participant_Sample-size
38
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Participant_Sample-size
41
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Participant_Condition
HCC
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Participant_Condition
early-stage HCC patients .