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document
Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography and computed tomography : comparison with 18-fluoro-2-deoxyglucose positron emission tomography . BACKGROUND The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile ( Tc-MIBI ) single photon emission computed tomography ( SPECT ) and computed tomography ( CT ) of the head and neck for differentiating recurrent or residual nasopharyngeal carcinomas ( NPC ) from benign lesions after radiotherapy was compared with positron emission tomography ( PET ) with 18-fluoro-2-deoxyglucose ( FDG ) . METHODS Thirty six NPC patients underwent head and neck CT , Tc-MIBI SPECT , and FDG-PET four months after radiotherapy to differentiate recurrent or residual NPC from benign lesions . Histopathologic examinations of nasopharyngeal biopsies were performed for all 36 patients . No patients had multiple foci of NPC . RESULTS Based on biopsy results , the sensitivity , specificity , and accuracy of CT for differentiating recurrent or residual NPC from benign lesions were 73 % , 88 % , and 83 % , respectively . The sensitivity , specificity , and accuracy of Tc-MIBI SPECT were 73 % , 96 % , and 89 % , respectively . The sensitivity , specificity , and accuracy of FDG-PET were 100 % , 96 % , and 97 % , respectively . Combination CT and Tc-MIBI SPECT for 28 NPC patients with congruent results showed the same sensitivity , specificity , and accuracy of 100 % , 96 % , and 96 % , respectively , as FDG-PET for differentiating recurrent or residual NPC from benign lesions . In eight patients with incongruent results between CT and Tc-MIBI SPECT , FDG-PET correctly differentiated two benign lesions and six recurrent or residual NPCs . CONCLUSIONS In detecting recurrent or residual NPC , FDG-PET is the best tool . However , combined use of CT and Tc-MIBI SPECT can result in the same accuracy as FDG-PET .
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Intervention_Physical
radiotherapy with technetium-99m methoxyisobutylisonitrile single photon emission computed tomography
8682
Intervention_Physical
computed tomography
8683
Intervention_Physical
18-fluoro-2-deoxyglucose positron emission tomography .
8684
Intervention_Physical
technetium-99m methoxyisobutylisonitrile ( Tc-MIBI ) single photon emission computed tomography ( SPECT )
8685
Intervention_Physical
computed tomography ( CT )
8686
Intervention_Physical
radiotherapy
8687
Intervention_Physical
positron emission tomography ( PET ) with 18-fluoro-2-deoxyglucose ( FDG )
8688
Intervention_Physical
CT
8689
Intervention_Physical
Tc-MIBI SPECT
8690
Intervention_Physical
FDG-PET
8691
Intervention_Physical
CT
8692
Intervention_Physical
Tc-MIBI SPECT
8693
Intervention_Physical
FDG-PET
8694
Intervention_Physical
FDG-PET
8695
Intervention_Physical
FDG-PET
8696
Intervention_Physical
CT
8697
Intervention_Physical
Tc-MIBI SPECT
8698
Intervention_Physical
FDG-PET
8699
Outcome_Physical
recurrent or persistent nasopharyngeal carcinomas
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Outcome_Other
sensitivity , specificity , and accuracy of CT
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Outcome_Physical
recurrent
8702
Outcome_Other
sensitivity , specificity , and accuracy of Tc-MIBI SPECT
8703
Outcome_Other
sensitivity , specificity , and accuracy of FDG-PET
8704
Outcome_Other
sensitivity , specificity , and accuracy
8705
Outcome_Physical
recurrent or residual NPC
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Outcome_Other
accuracy
8707
Participant_Condition
recurrent or persistent nasopharyngeal carcinomas after radiotherapy
8708
Participant_Condition
NPC
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Participant_Sample-size
Thirty six