73996
document
Antibiotic elimination of group-B streptococci in urine in prevention of preterm labour . The presence of group-B streptococci in the urine of pregnant women seems to be associated with preterm labour . Urine samples from 4122 women at 27-31 weeks ' gestation were examined for bacteria . Group-B streptococci were found in the urine of 69 women . In a double-blind , controlled study these patients were given either penicillin ( 10 ( 6 ) IU three times daily for 6 days ; 37 patients ) or placebo ( 32 patients ) . The rates of primary rupture of the membranes ( 11 % v 53 % ; p less than 0.001 ) and preterm labour ( 5.4 % v 38 % ; p less than 0.002 ) were significantly lower in the penicillin group than in the placebo group . These results suggest that treatment and follow-up to prevent recolonisation in pregnant women with group-B streptococci in the urine may reduce the frequency of preterm labour in these patients .
73997
Intervention_Pharmacological
penicillin
73998
Intervention_Control
placebo
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Intervention_Pharmacological
penicillin
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Intervention_Control
placebo
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Outcome_Physical
preterm labour
74002
Outcome_Physical
primary rupture of the membranes
74003
Outcome_Physical
preterm labour
74004
Outcome_Physical
frequency of preterm labour
74005
Participant_Condition
preterm labour
74006
Participant_Condition
pregnant
74007
Participant_Sex
women
74008
Participant_Sample-size
4122
74009
Participant_Sample-size
69
74010
Participant_Condition
pregnant
74011
Participant_Condition
group-B streptococci