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document
Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids , hemostatic parameters and carbohydrate metabolism . OBJECTIVE To compare the effect of ethinyl estradiol 20 microg/drospirenone 3 mg ( EE 20 microg/DRSP 3 mg ) administered according to a 24/4 regimen with ethinyl estradiol 20 microg/desogestrel 150 microg ( EE 20 microg/DSG 150 microg ) administered according to the conventional 21/7 regimen on lipid , carbohydrate and hemostatic parameters . STUDY DESIGN In this open-label study , healthy women were randomized to EE 20 microg/DRSP 3 mg or EE 20 microg/DSG 150 microg for seven cycles . Mean differences in high-density lipoprotein ( HDL ) - and low-density lipoprotein ( LDL ) -cholesterol levels at cycle 7 compared to baseline were assessed . Secondary variables included changes in other lipid , hemostatic and carbohydrate parameters . RESULTS Both treatments increased HDL-cholesterol , but decreased LDL-cholesterol by a comparable extent . Although slightly elevated in both groups , blood glucose and C-peptide levels measured during oral glucose tolerance tests were within normal reference ranges at cycle 7 . Overall , the differences in lipid , hemostatic or carbohydrate parameters were not significant between the two treatments . CONCLUSION EE 20 microg/DRSP 3 mg has a good safety profile comparable with EE 20 microg/DSG 150 microg .
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Intervention_Pharmacological
oral contraceptives
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Intervention_Pharmacological
ethinyl estradiol
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Intervention_Pharmacological
drospirenone
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Intervention_Pharmacological
desogestrel
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Intervention_Pharmacological
ethinyl estradiol 20 microg/drospirenone 3 mg
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Intervention_Pharmacological
ethinyl estradiol 20 microg/desogestrel
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Outcome_Physical
high-density lipoprotein ( HDL )
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Outcome_Physical
low-density lipoprotein ( LDL ) -cholesterol levels
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Outcome_Physical
other lipid , hemostatic and carbohydrate parameters
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Outcome_Physical
HDL-cholesterol
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Outcome_Physical
LDL-cholesterol
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Outcome_Physical
blood glucose and C-peptide levels
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Outcome_Physical
lipid
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Outcome_Physical
hemostatic or carbohydrate parameters
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Participant_Condition
healthy
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Participant_Sex
women