82450
document
Interferon treatment for hairy cell leukemia . An update on a cohort of 69 patients treated from 1983 to 1986 . We report follow-up information on 69 hairy cell leukemia ( HCL ) patients treated with interferon alfa-2b ( IFN ) as primary treatment from 1983 to 1986 . Follow-up through April , 1993 shows that only 14 patients have expired . Forty-seven of the 61 patients completing the intended 12 or more months of initial IFN treatment were eventually considered IFN failures . Forty-three required re-treatment ( 41 received a second course of IFN and 2 received pentostatin ) . Four patients died without further therapy for HCL . The median time to interferon failure was 31.3 months . Fourteen patients are alive and have not required further treatment after completing their initial 12 or more months of interferon . Fifteen patients underwent a third course of interferon therapy at a median time after completion of a second course of IFN of 1.0 year . Eighteen patients were eventually treated with pentostatin and ten with 2-chlorodeoxyadenosine ( 2-CdA ) . Thirteen patients developed a second malignancy ; six of these patients developed a hematologic malignancy between 44.6 months and 99.1 months after initiation of interferon therapy . We conclude that although interferon provides excellent palliation , that most patients will eventually require further treatment with interferon or chemotherapy . Future trials in HCL must be aware of the risk of second malignancies .
82451
Intervention_Pharmacological
interferon alfa-2b ( IFN )
82452
Intervention_Pharmacological
IFN
82453
Intervention_Pharmacological
IFN
82454
Intervention_Pharmacological
IFN
82455
Intervention_Pharmacological
pentostatin )
82456
Intervention_Pharmacological
interferon
82457
Intervention_Pharmacological
interferon
82458
Intervention_Pharmacological
interferon
82459
Intervention_Pharmacological
IFN
82460
Intervention_Pharmacological
pentostatin
82461
Intervention_Pharmacological
2-chlorodeoxyadenosine ( 2-CdA ) .
82462
Intervention_Pharmacological
interferon
82463
Intervention_Pharmacological
interferon
82464
Intervention_Pharmacological
interferon
82465
Intervention_Pharmacological
chemotherapy
82466
Outcome_Physical
hairy cell leukemia
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Outcome_Physical
hairy cell leukemia ( HCL )
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Outcome_Physical
HCL
82469
Outcome_Physical
second malignancy ;
82470
Outcome_Physical
hematologic malignancy
82471
Outcome_Physical
interferon
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Outcome_Physical
chemotherapy
82473
Outcome_Adverse-effects
second malignancies
82474
Participant_Condition
hairy cell leukemia
82475
Participant_Sample-size
69
82476
Participant_Sample-size
69
82477
Participant_Condition
hairy cell leukemia ( HCL )