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document
Treatment of posterior uveitis with a fluocinolone acetonide implant : three-year clinical trial results . OBJECTIVES To evaluate the safety and efficacy of 0.59-mg and 2.1-mg fluocinolone acetonide ( FA ) intravitreous implants in noninfectious posterior uveitis . DESIGN A 3-year , multicenter , randomized , historically controlled trial of the 0.59-mg FA intravitreous implant in 110 patients and the 2.1-mg FA intravitreous implant in 168 patients . MAIN OUTCOME MEASURES Recurrence rate , vision , and complications . RESULTS Uveitis recurrence was reduced in implanted eyes from 62 % ( during the 1-year preimplantation period ) to 4 % , 10 % , and 20 % during the 1- , 2- , and 3-year postimplantation periods , respectively , for the 0.59-mg dose group ( P < .01 ) and from 58 % to 7 % , 17 % , and 41 % , respectively , for the 2.1-mg dose group ( P < .01 ) . More implanted eyes than nonimplanted eyes had improved visual acuity ( P < .01 ) . Implanted eyes had higher incidences of intraocular pressure elevation ( > or = 10 mm Hg ) than nonimplanted eyes ( P < .01 ) , and glaucoma surgery was required in 40 % of implanted eyes vs 2 % of nonimplanted eyes ( P < .01 ) . Cataracts were extracted in 93 % of phakic implanted eyes vs 20 % of phakic nonimplanted eyes ( P < .01 ) . CONCLUSIONS The FA implant significantly reduced uveitis recurrence and improved or stabilized visual acuity in subjects with noninfectious posterior uveitis . Most subjects required cataract extraction , and a significant proportion required intraocular pressure-lowering surgery . APPLICATION TO CLINICAL PRACTICE The FA implant provides an alternative therapy for prolonged control of inflammation in noninfectious posterior uveitis . TRIAL REGISTRATION clinicaltrials.gov Identifier : NCT00407082 .
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Intervention_Pharmacological
fluocinolone acetonide implant
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Intervention_Pharmacological
fluocinolone acetonide
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Intervention_Pharmacological
0.59-mg FA intravitreous implant
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Outcome_Other
safety and efficacy
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Outcome_Physical
Recurrence rate
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Outcome_Physical
vision
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Outcome_Adverse-effects
complications
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Outcome_Physical
Uveitis recurrence
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Outcome_Physical
improved visual acuity
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Outcome_Physical
Implanted eyes had higher incidences of intraocular pressure elevation
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Outcome_Physical
glaucoma surgery
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Outcome_Physical
Cataracts
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Outcome_Physical
reduced uveitis recurrence
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Outcome_Physical
improved or stabilized visual acuity
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Outcome_Physical
cataract extraction
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Outcome_Physical
intraocular pressure-lowering surgery
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Participant_Condition
posterior uveitis
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Participant_Condition
noninfectious posterior uveitis
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Participant_Sample-size
110
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Participant_Sample-size
168
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Participant_Condition
noninfectious posterior uveitis