85130
document
[ Hemostatic balance during treatment with the newest contraceptives ] . Thirty-four healthy young women were allocated to 12 consecutive cycles of treatment with monophasic combinations of : 20 micrograms ethinyl estradiol and 150 micrograms desogestrel ( n = 15 ) or 30 micrograms ethinyl estradiol and 75 micrograms gestodene ( n = 19 ) . In both groups plasma levels of fibrinogen and factor VII increased while the capacity of coagulation inhibition was affected by increased protein C and decreased protein S levels . Increased fibrinolytic capacity was indicated by elevated activity and reduced antigen levels of tissue plasminogen activator and reduced activity and concentration of tissue plasminogen activator inhibitor . The ratio between thrombin-antithrombin-III-complexes and fibrin degradation products were unchanged signifying no effect of hormonal intake on the balance between thrombin formation and fibrin resolution . In conclusion , the dynamic balance between generation and resolution of fibrin was undisturbed during treatment with both hormonal compounds and our findings do not provide evidence for increased risk of thrombosis in normal women .
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Intervention_Pharmacological
monophasic combinations of : 20 micrograms ethinyl estradiol
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Intervention_Pharmacological
150 micrograms desogestrel
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Intervention_Pharmacological
30 micrograms ethinyl estradiol
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Intervention_Pharmacological
75 micrograms gestodene
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Outcome_Physical
plasma levels of fibrinogen and factor VII
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Outcome_Physical
increased protein C and decreased protein S levels .
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Outcome_Physical
fibrinolytic capacity
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Outcome_Physical
antigen levels of tissue plasminogen activator
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Outcome_Physical
concentration of tissue plasminogen activator inhibitor .
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Outcome_Physical
ratio between thrombin-antithrombin-III-complexes and fibrin degradation products
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Participant_Sample-size
Thirty-four
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Participant_Condition
healthy
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Participant_Age
young women
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Participant_Condition
normal
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Participant_Sex
women