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document
[ Study on classification and treatment of vulvovaginal candidiasis ] . OBJECTIVE To determine the clinical manifestations of vulvovaginal candidiasis ( VVC ) and to study the mycologic eradication rate of different miconazole treatment courses for VVC . METHODS Three hundred cases of VVC were recruited . The Candidas were cultured . A prospective and randomized study was performed to compare the treatment effect of 3 day miconazole ( 400 mg/d ) , 6 day miconazole ( 400 mg/d ) , and 7 day miconazole ( 200 mg/d ) for uncomplicated and complicated VVC . RESULTS Among 300 cases of VVC , uncomplicated , complicated and recurrent VVC were 56.0 % , 44.0 % and 9.7 % ( 29/300 ) respectively . C. albicans was isolated most frequently 90.3 % ( 271/300 ) , followed by C. glabrata ( 7.3 % ) , C. tropicalis ( 1.3 % ) , C. krusei ( 0.7 % ) , and C. parapsilosis ( 0.3 % ) . Mycologic eradication rate of 3 day , 6 day and 7 day miconazole courses for uncomplicated VVC at day 14 was 96.0 % , 93.5 % and 98.0 % , respectively ( P > 0.05 ) . Eradication rate of 3 day , 6 day and 7 day miconazole courses for complicated VVC at day 14 was 86.7 % , 92.5 % , and 86.4 % , respectively ( P > 0.05 ) . Eradication rate of 3 day , 6 day and 7 day miconazole courses for uncomplicated VVC at day 35 was 93.8 % , 95.3 % , and 89.8 % , respectively ( P > 0.05 ) . Eradication rate of 3 day , 6 day and 7 day miconazole courses for complicated VVC at day 35 was 89.7 % , 97.3 % and 86.8 % , respectively ( P > 0.05 ) . CONCLUSION Treatment of VVC should be individualized , and women with complicated VVC achieve superior mycologic eradication by a 6 day miconazole course .
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Intervention_Pharmacological
miconazole
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Intervention_Pharmacological
3 day miconazole
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Intervention_Pharmacological
6 day miconazole
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Intervention_Pharmacological
7 day miconazole
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Intervention_Pharmacological
miconazole
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Intervention_Pharmacological
miconazole
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Intervention_Pharmacological
miconazole
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Intervention_Pharmacological
miconazole
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Intervention_Pharmacological
miconazole
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Outcome_Physical
mycologic eradication rate
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Outcome_Physical
Mycologic eradication rate
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Outcome_Physical
Eradication rate
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Outcome_Physical
Eradication rate
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Outcome_Physical
Eradication rate
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Outcome_Physical
mycologic eradication
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Participant_Condition
vulvovaginal candidiasis
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Participant_Condition
vulvovaginal candidiasis ( VVC )
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Participant_Sample-size
Three hundred
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Participant_Condition
VVC
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Participant_Sample-size
300
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Participant_Sex
women
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Participant_Condition
VVC