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document
Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women : a randomized controlled trial . OBJECTIVE To determine the efficacy of stanol esters in lowering cholesterol in a US population . SUBJECTS AND METHODS After a run-in phase , 318 subjects were randomized to receive one of the following margarine-like spreads containing stanol ester or placebo for 8 weeks : EU 3 G : 1 g of stanol ( ester form ) per 8-g serving of a European formula 3 times a day ; US 3 G : 1 g of stanol ( ester form ) per 8-g serving of a US reformulation 3 times a day ; US 2 G : 0.67 g of stanol ( ester form ) per 8-g serving of a US reformulation 3 times a day ; or placebo spread . RESULTS Mean +/- SD baseline total cholesterol ( TC ) and low-density lipoprotein cholesterol ( LDL-C ) levels were 233+/-20 and 153+21 mg+/-dL , respectively . In the US 3 G group , 3 g daily of stanol esters lowered TC and LDL-C levels by 6.4 % and 10.1 % , respectively . There was a dose-dependent response compared with 2 g daily ( US 2 G ) . Triglyceride and high-density lipoprotein cholesterol levels were unchanged . The incidence of adverse effects was not different from placebo . Serum vitamin A and 25-hydroxyvitamin D levels were not affected . CONCLUSIONS Stanol esters lowered TC and LDL-C levels in a mildly hypercholesterolemic US population without evidence of adverse effects . It may be a useful dietary adjunct to lower cholesterol .
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Intervention_Pharmacological
stanol ester
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Intervention_Pharmacological
stanol esters
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Intervention_Pharmacological
stanol ester
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Intervention_Physical
placebo
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Intervention_Pharmacological
stanol ( ester form )
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Intervention_Pharmacological
stanol ( ester form )
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Intervention_Pharmacological
stanol
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Intervention_Control
placebo
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Intervention_Pharmacological
stanol esters
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Intervention_Control
placebo
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Intervention_Pharmacological
Stanol esters
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Outcome_Physical
Mean +/- SD baseline total cholesterol ( TC )
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Outcome_Physical
low-density lipoprotein cholesterol ( LDL-C ) levels
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Outcome_Physical
TC
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Outcome_Physical
LDL-C levels
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Outcome_Physical
Triglyceride and high-density lipoprotein cholesterol levels
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Outcome_Adverse-effects
adverse effects
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Outcome_Physical
Serum vitamin A and 25-hydroxyvitamin D levels
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Outcome_Physical
TC
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Outcome_Physical
LDL-C levels
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Participant_Condition
mildly hypercholesterolemic
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Participant_Sex
men
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Participant_Sex
women
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Participant_Sample-size
318
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Participant_Condition
mildly hypercholesterolemic