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document
Short-term metabolic effects of prednisone administration in healthy subjects . AIMS Supraphysiologic glucocorticoid activity is well established to cause impaired glucose tolerance and insulin resistance , yet no study has evaluated dose-dependent effects of low-dose prednisone during short-term oral administration . METHODS The objective of this study was to quantify the effects of daily 10 or 25 mg prednisone administration for one week on insulin sensitivity by employing a two-step hyperinsulinemic euglycemic glucose clamp ( Step 1 : insulin infusion = 20 mU/m²/min ; Step 2 : insulin infusion = 80 mU/m²/min ) in healthy , lean males . The amount of glucose infused at steady-state to maintain stable blood glucose [ 90 mg/dl ( 4.95 mmol/l ) ] was used to calculate several indices of insulin sensitivity . RESULTS During Step 1 of the clamp , whole body glucose disposal ( M ) was reduced by 35 % ( p = 0.003 ) and M/I was reduced by 29 % ( p = 0.025 ) for 25 mg prednisone compared to placebo . No appreciable effect of 10 mg prednisone was observed . During Step 2 , M was reduced by 33 % ( p = 0.001 ) and 15 % ( p = 0.006 ) for 25 and 10 mg prednisone compared to placebo ; and M/I ratio was reduced by 31 % ( p < 0.001 ) and 13 % ( p = 0.026 ) , respectively . The insulin sensitivity index , Si , calculated as the quotient of augmentation of M/I between Step 1 and 2 , was reduced by 35.3 % ( p < 0.01 ) and 23.5 % ( p < 0.05 ) for 25 and 10 mg prednisone , respectively . CONCLUSION Administration of relatively low pharmacological doses of prednisone for one week impaired insulin sensitivity in a dose-dependent manner in healthy males . These observed changes in insulin sensitivity are likely to be clinically relevant , especially in individuals predisposed to develop glucose intolerance .
50547
Intervention_Pharmacological
prednisone
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Intervention_Pharmacological
prednisone
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Intervention_Pharmacological
10 or 25 mg prednisone
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Intervention_Pharmacological
two-step hyperinsulinemic euglycemic glucose clamp
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Outcome_Other
effects
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Outcome_Physical
glucose tolerance
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Outcome_Physical
insulin resistance
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Participant_Condition
healthy