56922
document
Effects of conjugated linoleic acid supplementation and exercise on post-heparin lipoprotein lipase , butyrylcholinesterase , blood lipid profile and glucose metabolism in young men . This study was designed to investigate the effects of conjugated linoleic acid ( CLA ) supplementation and endurance exercise training-induced changes on post-heparin lipoprotein lipase ( PH-LPL ) and butyrylcholinesterase ( BChE ) activities along with leptin , insulin and lipid levels in plasma by a randomized double blind experiment . Eighteen sedentary male volunteers were randomly divided into CLA and Placebo ( PLC ) supplementation groups . Both groups underwent daily supplementation of either 3g CLA or 3g placebo for 30 days , respectively , and performed exercise on a bicycle ergometer 3 times per week for 30-40 min at 50 % VO2 peak workload . For plasma glucose , insulin and leptin levels and BChE activity fasting blood was used . For PH-LPL measurements , blood was collected 15 min after 50 IU/kg iv heparin injection . In all groups , there is a statistically significant decrease in BChE ( p = 0.03 , p = 0.02 ) and leptin ( p = 0.002 ) , insulin and HOMA-IR levels ( p = 0.02 ) . Exercise with or without CLA supplementation decreased insulin levels and increased insulin sensitivity . PH-LPL activity was increased significantly in both groups , displaying increased fatty acid mobilization . We conclude that though CLA supplementation and exercise can affect these parameters , CLA is not more effective than exercise alone . Hence , a prolonged supplementation regime may be more effective . Taken together in our small study group , our findings display that BChE is a potential marker for synthetic function of liver , fat metabolism , an obesity marker , a function long overlooked .
56923
Intervention_Pharmacological
conjugated linoleic acid supplementation
56924
Intervention_Educational
exercise
56925
Intervention_Pharmacological
conjugated linoleic acid ( CLA ) supplementation
56926
Intervention_Educational
endurance exercise
56927
Intervention_Other
randomly
56928
Intervention_Pharmacological
CLA
56929
Intervention_Control
Placebo ( PLC )
56930
Intervention_Pharmacological
CLA
56931
Intervention_Control
placebo
56932
Intervention_Physical
performed exercise on a bicycle ergometer 3 times per week for 30-40 min at 50 % VO2 peak workload
56933
Intervention_Pharmacological
CLA
56934
Intervention_Pharmacological
CLA
56935
Intervention_Pharmacological
CLA
56936
Outcome_Physical
post-heparin lipoprotein lipase , butyrylcholinesterase
56937
Outcome_Physical
blood lipid profile and glucose metabolism
56938
Outcome_Physical
butyrylcholinesterase ( BChE ) activities
56939
Outcome_Physical
plasma glucose , insulin and leptin levels and BChE activity fasting blood
56940
Outcome_Physical
PH-LPL measurements
56941
Outcome_Physical
BChE
56942
Outcome_Physical
leptin
56943
Outcome_Physical
insulin
56944
Outcome_Physical
HOMA-IR levels
56945
Outcome_Physical
insulin levels
56946
Outcome_Physical
insulin sensitivity
56947
Outcome_Physical
PH-LPL activity
56948
Outcome_Physical
BChE
56949
Participant_Age
young
56950
Participant_Sex
men
56951
Participant_Sample-size
Eighteen
56952
Participant_Sex
male