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document
Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis . INTRODUCTION It has been reported in an open-label study that the combination of alkalinized lidocaine and heparin can immediately relieve the symptoms of urinary urgency , frequency , and pain associated with interstitial cystitis ( IC ) . This combination has also been reported to relieve pain associated with sex in patients with IC . AIM The aim of this study was to corroborate these findings in a multicenter setting . METHODS The study design was a multicenter prospective , double-blind , crossover , placebo-controlled trial . Each participant met all of the clinical National Institute of Diabetes and Digestive and Kidney Diseases criteria ( excluding cystoscopy ) for IC . Each patient received drug and control , in random order , within 48 hours of enrolling in the study . MAIN OUTCOME MEASURES The primary outcome measure was percent change in pain score ( 11-point analog pain scale ) 12 hours after receiving the drug or control . Secondary measures were the global assessment response ( GAR ) of symptoms and 12-hour average urgency reduction determined from 11-point urgency scales . RESULTS Eighteen ( 18 ) patients completed the trial . The average reduction of pain over 12 hours was 21 % for control and 42 % for active drug ( P = 0.0363 ) . GAR was 13 % for control and 50 % for drug ( P = 0.0137 ) . Average urgency reduction was 13 % for control and 35 % for drug ( P = 0.0328 ) . CONCLUSIONS The combination of alkalinized lidocaine and heparin provides up to 12 hours of relief from urgency and pain associated with IC . This combination provides significant immediate relief of symptoms for patients with IC .
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Intervention_Pharmacological
Alkalinized lidocaine and heparin
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Intervention_Pharmacological
alkalinized lidocaine and heparin
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Intervention_Control
placebo-controlled
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Outcome_Pain
pain
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Outcome_Physical
urinary urgency , frequency
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Outcome_Pain
percent change in pain score ( 11-point analog pain scale )
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Outcome_Physical
symptoms
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Outcome_Physical
12-hour average urgency reduction
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Outcome_Pain
urgency and pain
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Participant_Condition
interstitial cystitis
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Participant_Condition
IC
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Participant_Condition
Diabetes
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Participant_Condition
Kidney Diseases
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Participant_Sample-size
18