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document
The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder . Autism is heterogeneous with respect to clinical symptoms and etiology . To sort out this heterogeneity in autism , we investigated whether specific neurobiological markers vary in parallel to core symptomatology . Specifically , we assessed growth hormone response to the 5-HT 1d agonist , sumatriptan , and linked this measure of serotonergic function to the severity of repetitive behaviors in adult autistic patients . Eleven adult patients with autism or Asperger 's disorder were randomized to single dose sumatriptan ( 6 mg SQ ) and placebo challenges , separated by a one-week interval . In adult autistic disorders , severity of repetitive behaviors at baseline , as measured by YBOCS-compulsion score , significantly positively correlated with both peak delta growth hormone response and area under the curve growth hormone response to sumatriptan . Thus , the severity of a specific behavioral dimension in autism ( repetitive behaviors ) parallels the sensitivity of the 5-HT 1d receptor , as manifest by sumatriptan elicited GH response .
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Intervention_Pharmacological
sumatriptan
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Intervention_Pharmacological
5-HT 1d agonist , sumatriptan
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Intervention_Pharmacological
sumatriptan
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Intervention_Control
placebo
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Intervention_Pharmacological
sumatriptan
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Intervention_Pharmacological
5-HT 1d receptor
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Intervention_Pharmacological
sumatriptan
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Outcome_Mental
repetitive behaviors
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Outcome_Physical
growth hormone response
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Outcome_Physical
specific neurobiological markers
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Outcome_Physical
core symptomatology
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Outcome_Physical
growth hormone response
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Outcome_Physical
linked this measure of serotonergic function
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Outcome_Mental
severity of repetitive behaviors
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Outcome_Adverse-effects
severity of repetitive behaviors
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Outcome_Physical
at baseline
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Outcome_Physical
measured by
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Outcome_Other
YBOCS-compulsion score
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Outcome_Physical
significantly positively correlated
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Outcome_Physical
peak delta growth hormone response
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Outcome_Physical
area under the curve growth hormone response
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Outcome_Other
severity of a specific behavioral dimension
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Outcome_Mental
( repetitive behaviors )
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Outcome_Physical
parallels the sensitivity
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Outcome_Physical
sumatriptan elicited GH response
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Participant_Age
adult
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Participant_Condition
autistic disorder
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Participant_Age
adult
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Participant_Condition
autistic
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Participant_Sample-size
Eleven
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Participant_Age
adult
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Participant_Condition
autism
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Participant_Condition
Asperger 's disorder