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document
Biodistribution of three photosensitizers in dogs with spontaneous tumors . Photodynamic therapy ( PDT ) has been considered a potential method for tumor eradication . The present study was designed to assess the efficacy of PDT as an alternative treatment approach . Photosensitizers , such as porfimer sodium , tin ethyl etiopurpurin , and aluminum chlorophthalocyanine , were administered i.v . to dogs , and tissue samples were harvested 24 to 300 hours later . The uptake of the photosensitizers in tumor ( fibrosarcoma ) and adjacent normal tissue biopsies was quantified by tissue solubilization technique and fluorimetry . In addition , the pharmacokinetics and selectivity of the photosensitizers were addressed by two-phase exponential function and specific uptake ratio , respectively . Porfimer sodium exhibited a longer elimination half-life ( 175.3 hr ) , slower clearance ( 0.0028 L/kg/hr ) , and a larger area under the curve ( 1075 microg/g/hr ) in tumors than did tin ethyl etiopurpurin or aluminum chlorophthalocyanine . As a result , porfimer sodium showed a good selectivity in tumors located in muscle and skin . The study provided clinical information for determination of the efficacy of different PDT alternatives .
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Intervention_Pharmacological
tin ethyl etiopurpurin
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Intervention_Pharmacological
aluminum chlorophthalocyanine .
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Outcome_Other
longer elimination half-life
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Outcome_Other
slower clearance
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Outcome_Other
larger area under the curve
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Outcome_Other
good selectivity in tumors located in muscle and skin
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Outcome_Other
efficacy
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Participant_Condition
dogs with spontaneous tumors .