52829
document
[ Clinical observations on the treatment of hookworm , Ascaris and Trichuris infection with oxibendazole ] . 340 cases of hookworm infection , 196 cases of ascariasis and 178 cases of trichuriasis were treated with an anthelmintic , oxibendazole , 15mg/kg.d x 3d ; 102 , 70 and 66 cases of respective infections were treated with pyrantel 10mg/kg.d x 3d and 108 , 74 and 63 cases took placebo for comparison and as control under double-blind observations . Re-examinations of the stool were performed after the treatment . Among the cases treated with oxibendazole , the egg negative conversion rates of hookworm , Ascaris and Trichuris were 70.3-80.6 % , 92.5-97.8 and 67.0-71.0 % respectively . The egg reduction rates of hookworm were 98.1-98.6 % . The larval negative conversion rates of Ancylostoma duodenale and Necator americanus were 77.7 and 83.2 % respectively . Among the cases treated with pyrantel , the egg negative conversion rates of the three above mentioned parasites were 73.5 , 90.0 and 28.8 % respectively . The egg reduction rate of hookworm was 98.8 % . Among the cases treated with placebo , the egg negative conversion rates of the three above mentioned parasites were 6.5 , 29.7 and 7.9 % . No marked adverse reactions were observed by clinical and laboratory examinations .
52830
Intervention_Pharmacological
oxibendazole
52831
Intervention_Pharmacological
anthelmintic , oxibendazole
52832
Intervention_Pharmacological
pyrantel
52833
Intervention_Control
placebo
52834
Outcome_Physical
egg negative conversion rates of hookworm
52835
Outcome_Physical
Ascaris
52836
Outcome_Physical
Trichuris
52837
Outcome_Other
egg reduction rates of hookworm
52838
Outcome_Physical
larval negative conversion rates of Ancylostoma duodenale and Necator americanus
52839
Outcome_Other
egg negative conversion rates
52840
Outcome_Other
egg reduction rate of hookworm
52841
Outcome_Other
egg negative conversion rates
52842
Participant_Condition
hookworm
52843
Participant_Condition
Ascaris
52844
Participant_Condition
Trichuris infection
52845
Participant_Sample-size
340
52846
Participant_Condition
hookworm infection
52847
Participant_Sample-size
196
52848
Participant_Condition
ascariasis
52849
Participant_Sample-size
178
52850
Participant_Condition
trichuriasis
52851
Participant_Condition
respective infections