90937
document
Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas . Forty-one consecutive patients with supratentorial primary brain tumors ( 38 Grade III and IV astrocytomas , one giant-cell astrocytoma , and two cases with insufficient tissue for diagnosis ) were randomly allocated within 2 weeks of surgery to one of three therapeutic groups . Group 1 ( 15 patients ) received radiation therapy totaling 4000 to 4500 rads in 4 to 5 weeks . Group 2 ( 13 patients ) received 1- ( 2-chloroethyl ) -3-cyclohexyl-1-nitrosourea CCNU ) 130 mg/sq m orally every 6 weeks . Group 3 ( 13 patients ) received radiation therapy plus CCNU as for Groups 1 and 2 . When the disease progressed , patients in Groups 1 and 2 were crossed over to receive CCNU and irradiation respectively . The median survival time in these groups was 188 , 259 , and 252 days , and the mean survival 263 , 262 , and 329 days . The median time from diagnosis to crossover ( Groups 1 and 2 ) or to progression ( Group 3 ) was 163 , 99 , and 220 days , and the mean time was 172 , 108 , and 231 days . There was no statistically significant difference between the means or medians in any of these situations .
90938
Intervention_Pharmacological
Radiotherapy
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Intervention_Pharmacological
CCNU
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Intervention_Pharmacological
radiation therapy
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Intervention_Pharmacological
1- ( 2-chloroethyl ) -3-cyclohexyl-1-nitrosourea CCNU )
90942
Intervention_Pharmacological
radiation therapy plus CCNU
90943
Intervention_Pharmacological
CCNU
90944
Outcome_Mortality
median survival time
90945
Outcome_Mortality
survival
90946
Outcome_Physical
median time from diagnosis to crossover ( Groups 1 and 2 ) or to progression
90947
Outcome_Other
means or medians
90948
Participant_Sample-size
Forty-one
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Participant_Condition
supratentorial primary brain tumors
90950
Participant_Sample-size
38
90951
Participant_Condition
Grade III and IV astrocytomas
90952
Participant_Sample-size
one
90953
Participant_Condition
giant-cell astrocytoma
90954
Participant_Sample-size
two