84916
document
Noradrenergic response to intravenous yohimbine in patients with depression and comorbidity of depression and panic . Adrenergic response following infusions of yohimbine or normal saline was evaluated in 9 control subjects , 8 patients suffering from a major depressive episode ( MDE ) , and 12 patients suffering from concurrent MDE and panic disorder ( MDE + P ) . Blood was drawn at -20 , 0 , 5 , 10 , 20 , 45 , and 90 min following the infusions , and assayed for norepinephrine ( NE ) and 3-methoxy-4-hydroxy-phenyl glycol ( MHPG ) . Although the patient groups exhibited higher baseline NE concentrations , and a greater NE area under the plasma concentration versus time curve ( AUC0-90 ) during the yohimbine infusion , the differences were not statistically significant . Baseline NE was significantly correlated with the NE AUC0-90 in all three groups , suggesting that , although the NE system may be dysregulated in the MDE and MDE + P patients , the NE system still appears to respond somewhat predictably following a challenge , even though the actual magnitude of response may vary .
84917
Intervention_Pharmacological
intravenous yohimbine
84918
Intervention_Pharmacological
yohimbine
84919
Intervention_Pharmacological
normal saline
84920
Intervention_Pharmacological
yohimbine
84921
Outcome_Physical
Noradrenergic response
84922
Outcome_Physical
Adrenergic response
84923
Outcome_Physical
norepinephrine ( NE ) and 3-methoxy-4-hydroxy-phenyl glycol ( MHPG
84924
Outcome_Physical
baseline NE concentrations
84925
Outcome_Physical
NE area under the plasma concentration versus time curve
84926
Outcome_Physical
Baseline NE
84927
Outcome_Physical
NE AUC0-90
84928
Participant_Condition
patients with depression and comorbidity of depression and panic
84929
Participant_Sample-size
9
84930
Participant_Condition
control subjects ,
84931
Participant_Sample-size
8
84932
Participant_Condition
major depressive episode ( MDE )
84933
Participant_Sample-size
12
84934
Participant_Condition
concurrent MDE and panic disorder ( MDE + P )