52089
document
Estrogen therapy for severe persistent depressions in women . Positive results are reported from a double-blind study of estrogen therapy administered to severely depressed , inpatient women who had failed to respond to various conventional treatments of depression . Large doses of oral conjugated estrogen were administered for a three-month period to 23 premenopausal and postmenopausal inpatient women . Placebos were administered for a comparable period to 17 similar patients . The posttreatment Hamilton ratings of depression were significantly reduced in the estrogen-treated group , but not in the placebo group . Possible physiological mechanisms are discussed . The risk-benefit ratio for estrogen therapy of depression in these patients was judged to be favorable . However , periodic endometrial biopsies are required to monitor the endometrial response of women receiving high doses of estrogens .
52090
Intervention_Pharmacological
Estrogen therapy
52091
Intervention_Pharmacological
estrogen therapy
52092
Intervention_Pharmacological
oral conjugated estrogen
52093
Intervention_Control
Placebos
52094
Intervention_Pharmacological
estrogen-treated
52095
Intervention_Control
placebo
52096
Intervention_Pharmacological
estrogen therapy
52097
Intervention_Pharmacological
estrogens
52098
Outcome_Mental
posttreatment Hamilton ratings of depression
52099
Outcome_Other
reduced
52100
Outcome_Other
risk-benefit ratio
52101
Outcome_Mental
depression
52102
Outcome_Other
favorable
52103
Participant_Condition
persistent depressions
52104
Participant_Sex
women
52105
Participant_Condition
severely depressed
52106
Participant_Sex
women
52107
Participant_Condition
depression
52108
Participant_Sample-size
23
52109
Participant_Sample-size
17
52110
Participant_Sample-size
women