7011
document
Penetration of ofloxacin and ciprofloxacin into the aqueous humor of eyes with functioning filtering blebs : a randomized trial . OBJECTIVE To determine concentrations of ofloxacin and ciprofloxacin hydrochloride in aqueous humor after topical or combined topical and oral administration in eyes with filtering blebs . DESIGN A prospective , investigator-masked , randomized , controlled comparative study involving 36 eyes of 34 patients with functioning filtering blebs who were to undergo cataract surgery . Treatment groups received either topical ofloxacin or topical ciprofloxacin ( instillation of 0.3 % ophthalmic solution every 30 minutes for 4 hours before surgery ) , or a combined topical plus oral regimen ( ciprofloxacin hydrochloride , four 100-mg tablets , or ofloxacin , one 400-mg tablet , administered 24-26 , 12-14 , and 2 hours preceding surgery ) . The main outcome measure was antibiotic concentration measured by chromatographic separation and mass spectrometry of aqueous samples obtained during surgery . RESULTS Topical antibiotic treatment yielded mean concentrations of ofloxacin , 0.75 microg/mL , and ciprofloxacin , 0.21 microg/mL , in aqueous . With combined topical and oral therapy , significantly more ofloxacin was measured than ciprofloxacin ( 3.84 microg/mL vs 0.35 microg/mL [ P < .001 ] ) . The combination regimen produced significantly greater ofloxacin levels than did topical therapy alone ( P =.007 ) . CONCLUSIONS Ofloxacin penetrates better than ciprofloxacin into the aqueous of eyes with filtering blebs , particularly after combined topical and oral administration , by which ofloxacin reaches more than a 10-fold greater concentration than does ciprofloxacin . Combined topical and oral therapy with ofloxacin may be beneficial in the treatment of bleb-associated infections .
7012
Intervention_Pharmacological
ofloxacin
7013
Intervention_Pharmacological
ciprofloxacin
7014
Intervention_Pharmacological
topical ofloxacin
7015
Intervention_Pharmacological
topical ciprofloxacin
7016
Intervention_Surgical
surgery
7017
Intervention_Pharmacological
( ciprofloxacin hydrochloride , four 100-mg tablets
7018
Intervention_Pharmacological
ofloxacin , one 400-mg tablet
7019
Intervention_Surgical
surgery
7020
Intervention_Pharmacological
ofloxacin
7021
Intervention_Pharmacological
ciprofloxacin
7022
Intervention_Pharmacological
topical and oral therapy with ofloxacin
7023
Outcome_Physical
antibiotic concentration
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Outcome_Physical
concentrations of ofloxacin
7025
Outcome_Physical
greater ofloxacin levels
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Outcome_Physical
ciprofloxacin
7027
Participant_Sample-size
36 eyes of 34 patients