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document
[ Effect of Preoperative Oral Rehydration on Onset Time and Recovery Time of Rocuronium ] . BACKGROUND Preoperative oral rehydration solution ( ORS ) prevents hypovolemia . The aim of this study was to compare the effect of intubating dose of rocuronium in patients taking and those not taking preoperative ORS . METHODS Twenty patients , ASA I aged 20-50 years scheduled for elective surgery , were investigated and randomly assigned to two groups : drinking 1,500 ml ORS 6 to 2 hours before anesthesia ( ORS group ) and nothing by mouth from 6 hours before anesthesia ( control group ) . Anesthesia was maintained with propofol and remifentanil , and rocuronium 0.6 mg x kg ( -1 ) was administrated . To evaluate the effect of rocuronium , acceleromyography at the adductor pollicis was performed using 0.1 Hz stimulation . Cardiac index ( CI ) and stroke volume variation ( SVV ) from FloTra/Vigileo , times to 95 % twitch depression as onset time ( OT ) , and times to first twitch re-detection ( TR ) were recorded . RESULTS SVV was significantly lower in ORS group ( P = 0.03 ) , and CI showed no difference . In ORS group , TR was significantly shorter than that of control group ( P=0.002 ) , and OT tended to be prolonged ( 99.0 ± 36.3 s vs. 84.0 ± 37.5 s ) , but not significantly . CONCLUSIONS Preoperative oral rehydration possibly increases circulating blood volume , and shortens the duration of rocuronium effect .
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Intervention_Pharmacological
Preoperative Oral Rehydration
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Intervention_Pharmacological
oral rehydration solution ( ORS )
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Intervention_Pharmacological
rocuronium
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Intervention_Pharmacological
ORS .
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Intervention_Pharmacological
ORS
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Intervention_Pharmacological
( ORS group )
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Intervention_Control
nothing by mouth
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Intervention_Control
( control group )
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Intervention_Pharmacological
propofol
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Intervention_Pharmacological
remifentanil
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Intervention_Pharmacological
rocuronium
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Intervention_Pharmacological
ORS
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Intervention_Pharmacological
ORS
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Outcome_Physical
Rehydration
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Outcome_Physical
rehydration
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Outcome_Physical
hypovolemia .
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Outcome_Physical
preoperative ORS
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Outcome_Physical
Cardiac index ( CI ) and stroke volume variation ( SVV )
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Outcome_Other
depression
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Outcome_Other
onset time ( OT )
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Outcome_Other
twitch re-detection ( TR )