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document
A controlled study of the effect of indomethacin in uremic pericarditis . To determine the impact of indomethacin on the course of uremic pericarditis we performed a prospective , double blind study in which 24 patients with endstage chronic renal failure and pericarditis randomly received indomethacin , 25 mg four times daily , ( 11 patients ) or a placebo ( 13 patients ) for a 3-week period . All patients received peritoneal or hemodialysis treatment concurrently with the study drug . In contrast to the placebo , indomethacin produced an immediate and sustained reduction of fever in all but one patient . On the other hand , indomethacin had no effect on the duration of chest pain ( mean days +/- SE : placebo 1.4 +/- 0.6 , indomethacin 5.5 +/- 3.3 ) , duration of pericardial friction rub ( placebo 10.3 +/- 1.7 , indomethacin 16.0 +/- 3.8 ) , or on the amount of pericardial effusion . Further , indomethacin did not diminish the need for invasive surgical procedures for relief of tamponade ( three of 13 placebo patients , two of 11 indomethacin patients ) or result in decreased mortality rate . Death ( not due to pericarditis ) occurred in two patients treated with indomethacin and one patient who received the placebo . In our patients pericarditis encompassed a wide spectrum ranging from a mild illness of several days duration to a painful and debilitating disease lasting weeks and requiring surgical intervention . Although the size of our population prohibits definitive conclusions , it would appear that , except for fever , the manifestations and natural history of this illness are unaffected by indomethacin .
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Intervention_Pharmacological
indomethacin
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Intervention_Pharmacological
indomethacin
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Intervention_Pharmacological
indomethacin
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
indomethacin
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Intervention_Pharmacological
indomethacin
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Intervention_Control
placebo
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Intervention_Pharmacological
indomethacin
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Intervention_Pharmacological
indomethacin
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Intervention_Control
placebo
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Intervention_Pharmacological
indomethacin
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Outcome_Other
effect
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Outcome_Physical
uremic pericarditis .
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Outcome_Physical
reduction of fever
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Outcome_Pain
duration of chest pain
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Outcome_Physical
pericardial friction rub
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Outcome_Physical
pericardial effusion .
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Outcome_Physical
need for invasive surgical procedures
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Outcome_Physical
tamponade
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Outcome_Mortality
mortality rate . Death
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Outcome_Physical
mild illness of several days duration
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Outcome_Physical
painful and debilitating disease lasting weeks
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Outcome_Other
surgical intervention
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Outcome_Physical
illness