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document
[ Potentiation of the effect of non-depolarizing muscle relaxants by acylaminopenicillins . Studies on the example of vecuronium ] . In a prospective controlled clinical study interactions between nondepolarizing muscle relaxants and acylaminopenicillins were investigated electromyographically . Six patients in each group received either apalcillin , azlocillin , mezlocillin or piperacillin during the operation . Muscle relaxation was maintained using the short acting nondepolarizing relaxant vecuronium , which shows no cumulative effect within clinical dosages . The intra-individual comparison with the control period ( 100 % ) showed a significant prolongation of the duration of action after a fixed dose of vecuronium . The mean increase was +26 % following apalcillin , +46 % after piperacillin , +38 % following mezlocillin and +55 % following azlocillin . The shortest time of the control periods was 8.6 min and the maximum time was 32.6 min . We also found a significant depression of the EMG-response . No significant differences could be detected between the four antibiotics . The method described here has proven to be sensitive enough to detect clinically relevant interactions with muscle relaxants . As a result of our study , caution seems to be necessary if acylaminopenicillins are administered in the early postoperative period .
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Intervention_Pharmacological
acylaminopenicillins
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Intervention_Pharmacological
nondepolarizing muscle relaxants
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Intervention_Pharmacological
acylaminopenicillins
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Intervention_Pharmacological
apalcillin , azlocillin , mezlocillin or piperacillin
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Intervention_Pharmacological
acylaminopenicillins
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Outcome_Pain
Muscle relaxation
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Outcome_Other
prolongation of the duration of action
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Outcome_Other
mean increase
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Outcome_Other
shortest time
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Outcome_Mental
depression
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Outcome_Physical
EMG-response
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Outcome_Pain
clinically relevant interactions
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Outcome_Pain
muscle relaxants
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Participant_Condition
Six