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document
Double-blind , placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders . L-Carnosine , a dipeptide , can enhance frontal lobe function or be neuroprotective . It can also correlate with gamma-aminobutyric acid ( GABA ) -homocarnosine interaction , with possible anticonvulsive effects . We investigated 31 children with autistic spectrum disorders in an 8-week , double-blinded study to determine if 800 mg L-carnosine daily would result in observable changes versus placebo . Outcome measures were the Childhood Autism Rating Scale , the Gilliam Autism Rating Scale , the Expressive and Receptive One-Word Picture Vocabulary tests , and Clinical Global Impressions of Change . Children on placebo did not show statistically significant changes . After 8 weeks on L-carnosine , children showed statistically significant improvements on the Gilliam Autism Rating Scale ( total score and the Behavior , Socialization , and Communication subscales ) and the Receptive One-Word Picture Vocabulary test ( all P < .05 ) . Improved trends were noted on other outcome measures . Although the mechanism of action of L-carnosine is not well understood , it may enhance neurologic function , perhaps in the enterorhinal or temporal cortex .
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
L-carnosine supplementation
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Intervention_Pharmacological
L-Carnosine
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Intervention_Pharmacological
dipeptide
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Intervention_Pharmacological
L-carnosine
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
L-carnosine
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Intervention_Pharmacological
L-carnosine
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Outcome_Physical
Childhood Autism Rating Scale
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Outcome_Mental
, the Gilliam Autism Rating Scale , the Expressive and Receptive One-Word Picture Vocabulary tests , and Clinical Global Impressions of Change
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Outcome_Mental
Gilliam Autism Rating Scale ( total score and the Behavior , Socialization , and Communication subscales ) and the Receptive One-Word Picture Vocabulary test
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Participant_Age
children
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Participant_Condition
autistic spectrum disorders
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Participant_Sample-size
31