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[ Clinical observation on acupuncture combined with Yizhi Jiannao granules for treatment of Alzheimer 's disease ] . OBJECTIVE To observe clinical therapeutic effect of acupuncture combined with Yizhi Jiannao Granules for treatment of Alzheimer 's disease and its effects on intelligence , daily life and social activity ability . METHODS Eighty-four cases were randomly divided into 3 groups , 28 cases in each group . The combined acupuncture and medication group was treated with acupuncture at Baihui ( GV 20 ) , Sishencong ( EX-HN 1 ) , Dazhui ( GV 14 ) , Guanyuan ( CV 4 ) , etc . and oral administration of Yizhi Jiannao Granules ; the Chinese herb group was treated with Yizhi Jiannao Granules , and the western medicine group with oral administration of Aricept . The scores for the Mini-Mental State Examination ( MMSE ) , Ability of Daily Life ( ADL ) and the therapeutic effects were assessed and compared before treatment and after treatment for 12 weeks among the groups . RESULTS After treatment , the scores for MMSE and ADL were improved in the combined acupuncture and medication group , the Chinese herb group and the western medicine group , which were better in the combined acupuncture and medication group ( P < 0.05 ) . The total effective rate of 85.7 % in the combined acupuncture and medication group was better than 71.4 % in the Chinese herb group and 67.9 % in the western medicine group . CONCLUSION Acupuncture combined with Yizhi Jiannao Granules has a significant therapeutic effect on Alzheimer 's disease , which is better than that of Yizhi Jiannao Granules or Aricept .
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Intervention_Physical
acupuncture
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Intervention_Pharmacological
Yizhi Jiannao granules
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Intervention_Physical
acupuncture
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Intervention_Pharmacological
Yizhi Jiannao Granules
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Intervention_Physical
acupuncture
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Intervention_Physical
acupuncture
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Intervention_Pharmacological
Yizhi Jiannao Granules
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Intervention_Pharmacological
Yizhi Jiannao Granules
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Intervention_Pharmacological
western medicine group
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Intervention_Pharmacological
Aricept
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Intervention_Physical
combined acupuncture and medication
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Intervention_Pharmacological
Chinese herb
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Intervention_Pharmacological
western medicine
40990
Intervention_Physical
acupuncture and medication
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Intervention_Physical
combined acupuncture and medication
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Outcome_Adverse-effects
therapeutic effect
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Outcome_Mental
intelligence
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Outcome_Mental
daily life
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Outcome_Mental
social activity ability
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Outcome_Other
scores for the Mini-Mental State Examination ( MMSE )
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Outcome_Physical
Ability of Daily Life ( ADL )
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Outcome_Adverse-effects
the therapeutic effects
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Outcome_Physical
MMSE
41000
Outcome_Physical
ADL
41001
Outcome_Physical
total effective rate
41002
Outcome_Physical
therapeutic effect
41003
Participant_Sample-size
Eighty-four
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Participant_Sample-size
3 groups
41005
Participant_Sample-size
28