44682
document
Effect of membrane permeability on inflammation and arterial stiffness : a randomized trial . BACKGROUND AND OBJECTIVES Both larger molecule removal and dialyzer biocompatibility have been implicated in the high-flux hemodialysis ( HD ) -associated favorable outcome . In an attempt to delineate the effect of membrane permeability , we performed a randomized , crossover study to compare the inflammatory biomarkers , lipid profile , and aortic pulse wave velocity ( PWV ) of two dialyzers that are composed of identical membranes but with different flux characteristics . DESIGN , SETTING , PARTICIPANTS , & MEASUREMENTS Stable patients who had anuria and were on low-flux polysulfone membrane were randomly allocated either to HD with high-flux polyamide membrane ( group A ; 22 patients ) or to HD with low-flux polyamide membrane ( group B ; 24 patients ) for 24 weeks , then they were started on 24 weeks of the alternative HD treatment . Apart from the dialyzer , the dialysis prescription remained unchanged . RESULTS Nineteen patients from group A and 23 patients from group B completed the study . Predialysis beta ( 2 ) -microglobulin levels decreased significantly when using the high-flux polyamide membrane . No difference between membranes was observed for serum albumin , high-sensitivity C-reactive protein , fibrinogen , IL-6 , triglycerides , HDL cholesterol , LDL cholesterol , and lipoprotein ( a ) during the study . A significant increase in aortic PWV , a marker of aortic stiffness , was noted after patients switched from high-flux to low-flux polyamide membranes . Similarly , the rate of change in aortic PWV was significantly decreased with the use of the high-flux polyamide membrane . CONCLUSIONS Our findings suggest that dialysis with polyamide membranes with different flux characteristics did not modify the inflammatory indices and lipid profile in stable HD patients ; however , a seemingly beneficial effect on aortic stiffness was noted for patients who were maintained on high-flux polyamide membrane .
44683
Intervention_Physical
high-flux hemodialysis
44684
Intervention_Physical
HD with high-flux polyamide membrane
44685
Intervention_Physical
HD with low-flux polyamide membrane
44686
Intervention_Physical
alternative HD treatment
44687
Intervention_Physical
high-flux polyamide membrane
44688
Intervention_Physical
high-flux
44689
Intervention_Physical
low-flux polyamide membranes
44690
Intervention_Physical
high-flux polyamide membrane
44691
Intervention_Physical
polyamide membranes
44692
Intervention_Physical
high-flux polyamide membrane
44693
Outcome_Other
Effect
44694
Outcome_Physical
Predialysis beta ( 2 ) -microglobulin levels
44695
Outcome_Physical
serum albumin , high-sensitivity C-reactive protein , fibrinogen , IL-6 , triglycerides , HDL cholesterol , LDL cholesterol , and lipoprotein ( a )
44696
Outcome_Physical
aortic PWV , a marker of aortic stiffness
44697
Outcome_Physical
rate of change in aortic PWV