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Characterization of early thermal burns and the effects of hyperbaric oxygen treatment : a pilot study . BACKGROUND AND AIMS Studies investigating hyperbaric oxygen treatment ( HBOT ) to improve outcome in burns have been inconclusive . In this study , we aimed to characterize early thermal burns injury in adult patients with < 40 % total body surface area ( TBSA ) and to determine the effects of HBOT administered within 24 h to 48 h of a burn injury . METHODS Seventeen subjects were randomized into control ( n = 9 ) and HBOT treatment ( n = 8 ) arms . Burn depth , measured by laser Doppler imaging ( LDI ) and histologically , white blood cell ( WBC ) count and plasma cytokine inflammatory markers were assessed at 24 h ( pre HBOT ) and 48 h ( post HBOT ) post burn , as were immunohistochemistry and microbiology of burns tissue samples at 48 h post burn . RESULTS WBC count and serum interleukin ( IL ) -1β , IL-4 , IL-6 , IL-10 and interferon-γ were significantly elevated 24 h after burn , but no significant changes in any of these parameters were found with HBOT . HBOT had no significant effect on burn depth . Two HBOT patients and four control patients developed positive bacterial cultures . CONCLUSIONS Slower than anticipated recruitment resulted in considerably fewer patients than planned being studied . Inflammatory markers were significantly increased at 24 h in patients with < 40 % TBSA burn . Early HBOT had no apparent effects on any of the parameters measured in this small pilot study . HBOT may possibly have a broad-spectrum antimicrobial effect worthy of further study . We report our methodology in detail as a possible model for future burns studies .
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Intervention_Physical
hyperbaric oxygen treatment
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Intervention_Physical
hyperbaric oxygen treatment ( HBOT )
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Intervention_Physical
HBOT
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Intervention_Physical
HBOT treatment
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Intervention_Physical
Doppler imaging
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Outcome_Physical
Burn depth
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Outcome_Physical
white blood cell ( WBC ) count
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Outcome_Physical
plasma cytokine inflammatory markers
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Participant_Condition
burns
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Participant_Condition
early thermal burns injury
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Participant_Age
adult
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Participant_Condition
< 40 % total body surface area ( TBSA
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Participant_Sample-size
Seventeen
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Participant_Sample-size
9
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Participant_Sample-size
8