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document
Mefloquine kinetics in cured and recrudescent patients with acute falciparum malaria and in healthy volunteers . Mefloquine pharmacokinetics were compared in a randomized clinical trial in Thailand among patients with malaria and healthy volunteers . A single oral dose of 1500 mg mefloquine hydrochloride was administered to 11 patients and 5 volunteers and 750 mg was given to 16 patients and 5 volunteers . Efficacy was 82 % for 1500 mg and 63 % for 750 mg . In cured patients taking 750 mg mefloquine , peak plasma drug concentration ( Cmax ) and area under the plasma concentration-time curve ( AUC ) were significantly greater than in the patients for whom treatment failed ( p less than 0.0005 and p less than 0.01 , respectively ) , and plasma mefloquine levels were significantly higher from 8 hours to 18 days after treatment . Mefloquine AUC was reduced and variable in the presence of diarrhea . Compared with noninfected volunteers , clinically ill patients displayed a delayed time to reach peak concentration ( p less than 0.01 ) and significantly higher mefloquine plasma levels in the first 2 days after administration of either the 750 mg or the 1500 mg dose . Mefloquine AUC was similar in patients with malaria and healthy volunteers . Because plasma levels increased in temporal relationship with clinical illness , mefloquine volume of distribution or clearance ( or both ) was reduced during the acute phase of illness .
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Intervention_Pharmacological
Mefloquine kinetics
53493
Intervention_Pharmacological
Mefloquine
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Intervention_Pharmacological
mefloquine hydrochloride
53495
Intervention_Pharmacological
mefloquine
53496
Outcome_Other
Efficacy
53497
Outcome_Physical
peak plasma drug concentration
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Outcome_Other
( Cmax )
53499
Outcome_Other
area under the plasma concentration-time curve ( AUC )
53500
Outcome_Other
plasma mefloquine levels
53501
Outcome_Physical
Mefloquine AUC
53502
Outcome_Other
time to reach peak concentration
53503
Outcome_Physical
mefloquine plasma levels
53504
Outcome_Other
Mefloquine AUC
53505
Participant_Condition
Mefloquine kinetics in cured and recrudescent patients with acute falciparum malaria and in healthy volunteers .
53506
Participant_Condition
clinical trial in Thailand among patients with malaria and healthy volunteers .