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document
Is Na+ modeling necessary in high flux dialysis ? One important pathogenic factor in dialysis hypotension is the drop in plasma osmolality . Increasing the dialysate Na+ concentration decreases hypotensive episodes . The authors studied 39 patients being treated with high flux dialysis . During a 9 week period , the patients were on a standard Na+ dialysate ( Na+ = 140 meq/L ) basal period ( B ) ; 9 % ( Na+ = 149 meq/L ) linear ( L ) ; step drop ( S ) ; and exponential drop ( E ) . The Na+ program was changed weekly at random . The results obtained with the three Na+ modeling programs were similar . We compared the periods with and without Na+ modeling : no differences were found in weight gained interdialysis , mean blood pressure predialysis and postdialysis , and hemoconcentration . Serum Na+ levels were significantly higher predialysis and postdialysis for those patients on Na+ modeling . Hypotensive episodes and cramps decreased 50 % with Na+ modeling . The amount of hypertonic and normal saline given during dialysis was markedly reduced . Na+ modeling should always be used in patients being maintained on high flux dialysis .
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Intervention_Pharmacological
Na+ modeling
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Intervention_Pharmacological
Na+
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Intervention_Physical
high flux dialysis
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Intervention_Pharmacological
standard Na+ dialysate
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Intervention_Physical
linear
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Intervention_Physical
Na+ program
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Intervention_Pharmacological
Na+ modeling
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Intervention_Pharmacological
Na+ modeling
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Intervention_Pharmacological
Na+ modeling
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Intervention_Pharmacological
Na+ modeling
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Intervention_Pharmacological
Na+ modeling
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Intervention_Physical
high flux dialysis
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Outcome_Physical
weight gained interdialysis
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Outcome_Physical
mean blood pressure predialysis and postdialysis
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Outcome_Physical
hemoconcentration
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Outcome_Physical
Serum Na+ levels
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Outcome_Physical
Hypotensive episodes and cramps
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Outcome_Physical
amount of hypertonic and normal saline