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document
Bites by the saw-scaled or carpet viper ( Echis carinatus ) : trial of two specific antivenoms . Echis carinatus is the most important cause of morbidity and mortality from snake bite in Nigeria and in many other parts of the world . Forty-six patients with systemic poisoning by this snake were given echis antivenom made either by the South African Institute for Medical Research ( S.A.I.M.R . ) or by Behringwerke ( North and West African polyvalent antivenom ) . A simple test of blood coagulability was used to assess whether an adequate neutralizing dose of antivenom had been given . An average of 15.2 ml S.A.I.M.R . antivenom restored normal coagulability permanently in all 23 patients in one group , but in the other group receiving an average dose of 37.9 ml Behringwerke antivenom normal clotting resulted in only 18 out of 23 patients . Local tissue swelling was similar in both groups , but local necrosis occurred in three patients treated with Behringwerke antivenom and in none given S.A.I.M.R . antivenom .
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Intervention_Pharmacological
echis antivenom made either by the South African Institute for Medical Research ( S.A.I.M.R . )
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Intervention_Pharmacological
S.A.I.M.R .
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Intervention_Pharmacological
Behringwerke antivenom
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Intervention_Pharmacological
Behringwerke antivenom
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Outcome_Physical
blood coagulability
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Outcome_Physical
normal coagulability
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Outcome_Physical
normal clotting
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Outcome_Physical
Local tissue swelling
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Outcome_Physical
local necrosis
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Participant_Sample-size
Forty-six
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Participant_Condition
systemic poisoning by this snake
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Participant_Sample-size
23
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Participant_Condition
patients in one group