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document
Comparison of endocrine and radiation therapy in locally advanced prostatic cancer . 151 patients with locally advanced prostatic cancer ( T3-4 M0 ) , representing 38 % of the 404 cancer patients in a Finnish multicenter study , were randomly assigned to one of three treatment arms : orchiectomy , estrogens or radiotherapy . During the 4-year follow-up period there were no significant differences in the progression rates ( appearance of metastases in bone scan ) between the therapy groups . The frequency of thromboembolic and other cardiovascular complications was highest in the estrogen group ( 13/50 patients ) . In the radiotherapy group , 19 of 45 patients had bowel or bladder complications . On the other hand , orchiectomy has few , if any , complications . The high risk of complications associated with estrogens and radiotherapy has to be taken into consideration in the selection of treatment .
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Intervention_Pharmacological
endocrine
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Intervention_Physical
radiation therapy
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Intervention_Surgical
orchiectomy
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Intervention_Pharmacological
estrogens
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Intervention_Physical
radiotherapy
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Outcome_Other
progression rates
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Outcome_Physical
( appearance of metastases in bone scan )
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Outcome_Adverse-effects
frequency of thromboembolic and other cardiovascular complications
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Outcome_Adverse-effects
bowel or bladder complications
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Participant_Condition
locally advanced prostatic cancer .
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Participant_Sample-size
151
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Participant_Condition
( T3-4 M0 )
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Participant_Condition
representing 38 % of the 404 cancer patients in a Finnish multicenter study