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document
Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension . OBJECTIVE Transient lower esophageal sphincter relaxations ( TLESRs ) are the main mechanism underlying gastroesophageal reflux . In the present study we evaluated the effect of loxiglumide , a specific cholecystokininA ( CCKA ) -receptor antagonist , on the occurrence of TLESRs evoked by gastric distension . METHODS Eight healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in a randomized double-blind order . Gastric distension was induced by inflation of 400 ml of air . RESULTS Basal lower esophageal pressure ( LESP ) and swallow-induced relaxation were not affected by loxiglumide . Loxiglumide significantly reduced the number of TLESRs , from 11.5 ( 5.8-18.3 ) to 6.0 ( 3.3-14.3 ) during the total recording period of 1 h , and from 5.5 ( 4.25-7.5 ) to 2.0 ( 0.5-6.8 ) during the first 15 min . The number of common cavities was significantly decreased by loxiglumide , from 8.0 ( 4.0-20.0 ) to 5.0 ( 2.0-7.8 ) . TLESRs represented the main mechanism ( 60 % during placebo , 74 % during loxiglumide ) underlying common cavities , followed by swallow-induced relaxation . CONCLUSIONS Loxiglumide significantly reduces the number of TLESRs triggered by gastric distension without interfering with swallow-related relaxation of the lower esophageal sphincter , suggesting the involvement of CCKA receptors in the reflex pathway mediating TLESRs .
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Intervention_Physical
10-lumen sleeve assembly during placebo
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Intervention_Pharmacological
loxiglumide
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Outcome_Physical
Transient lower esophageal sphincter relaxations ( TLESRs )
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Outcome_Physical
Basal lower esophageal pressure ( LESP )
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Outcome_Physical
swallow-induced relaxation
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Outcome_Physical
TLESRs
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Outcome_Physical
number of common cavities
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Outcome_Physical
TLESRs
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Outcome_Physical
TLESRs
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Participant_Sample-size
Eight
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Participant_Condition
healthy subjects underwent esophageal manometry using a 10-lumen sleeve assembly during placebo or loxiglumide ( 10 mg/kg/h ) in