20045
document
A randomized , evaluator-blind , multicenter comparison of the efficacy and tolerability of Perlane versus Zyplast in the correction of nasolabial folds . Bovine collagen is widely used as a dermal filler for facial soft-tissue augmentation , but it provides only temporary cosmetic improvement . Nonanimal stabilized hyaluronic acid has reduced potential for immunogenicity and hypersensitivity and may provide a more durable aesthetic result . Sixty-eight patients with prominent nasolabial folds were randomized to intradermal treatment with nonanimal stabilized hyaluronic acid gel ( Perlane ) and bovine collagen ( Zyplast ) on contralateral sides of the face . On achievement of " optimal cosmetic result " ( baseline ) , patients were followed up for 6 months ; bilateral retreatment with Perlane was offered at 6 or 9 months after baseline . Responses were evaluated at 2 , 4 , 6 , 9 , and 12 months after baseline . Investigator-based and patient-based ratings indicated that Perlane was more effective than Zyplast in maintaining cosmetic correction . According to investigator-based Wrinkle Severity Rating Scale assessments at 6 and 9 months after baseline , Perlane was superior in 50.0 percent and 48.8 percent of patients , respectively , whereas Zyplast was superior in 10.3 percent and 14.0 percent of patients , respectively ( p < 0.0004 ) . Investigator-based Global Aesthetic Improvement Scale assessment at 9 months after baseline indicated that Perlane was superior in 48.8 percent of patients , whereas Zyplast was superior in 14.0 percent of patients ( p = 0.0025 ) . " Optimal cosmetic result " was achieved with a smaller volume of Perlane than Zyplast ( mean , 1.2 ml versus 2.1 ml ) . Local injection-site reactions ( redness , swelling , pruritus , and induration ) were less frequent with Perlane than with Zyplast . Delayed-onset reactions were rare and did not reoccur after Perlane retreatment . Perlane has acceptable long-term safety and offers a longer-lasting aesthetic improvement than Zyplast .
20046
Intervention_Pharmacological
Perlane
20047
Intervention_Pharmacological
Zyplast
20048
Intervention_Pharmacological
Bovine collagen
20049
Intervention_Pharmacological
Nonanimal stabilized hyaluronic acid
20050
Intervention_Pharmacological
intradermal treatment with nonanimal stabilized hyaluronic acid gel ( Perlane )
20051
Intervention_Pharmacological
bovine collagen ( Zyplast )
20052
Intervention_Pharmacological
Perlane
20053
Intervention_Pharmacological
Perlane
20054
Intervention_Pharmacological
Zyplast
20055
Intervention_Pharmacological
Perlane
20056
Intervention_Pharmacological
Zyplast
20057
Intervention_Pharmacological
Perlane
20058
Intervention_Pharmacological
Zyplast
20059
Intervention_Pharmacological
Perlane
20060
Intervention_Pharmacological
Zyplast
20061
Intervention_Pharmacological
Perlane
20062
Intervention_Pharmacological
Zyplast
20063
Intervention_Pharmacological
Perlane
20064
Intervention_Pharmacological
Perlane
20065
Intervention_Pharmacological
Zyplast
20066
Outcome_Physical
optimal cosmetic result
20067
Outcome_Physical
cosmetic
20068
Outcome_Physical
investigator-based Wrinkle Severity Rating Scale assessments
20069
Outcome_Other
superior
20070
Outcome_Other
superior
20071
Outcome_Physical
Global Aesthetic Improvement Scale assessment
20072
Outcome_Other
superior
20073
Outcome_Other
superior
20074
Outcome_Physical
" Optimal cosmetic result "
20075
Outcome_Other
smaller volume
20076
Outcome_Adverse-effects
reactions ( redness , swelling , pruritus , and induration )
20077
Outcome_Other
long-term safety
20078
Outcome_Physical
aesthetic improvement