50990
document
Behavioral effects of Org 2766 , a synthetic analog of the adrenocorticotrophic hormone ( 4-9 ) , in 14 outpatient autistic children . Fourteen children ( 12 infantile autism full syndrome present , 2 atypical pervasive developmental disorder ) between 5 and 13 years of age participated in a double-blind placebo-controlled cross-over trial . Each child received 20 mg Org 2766 ( synthetic analog of ACTH 4-9 ) /day during 4 weeks , or placebo in a randomly assigned sequence . Drug effects were monitored by ethological playroom observation and by Aberrant Behavior Checklist ratings by parents and teachers . Data of the playroom observation pointed to an activating influence of Org 2766 , as revealed by a significant decrease of stereotypic behavior and significant increases in " change toys , " " locomote , " and " talk . " Checklist ratings did not show significant changes . The clinical implications of these findings are discussed .
50991
Intervention_Pharmacological
Org 2766
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Intervention_Pharmacological
Org 2766
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Intervention_Pharmacological
synthetic analog of ACTH
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Intervention_Control
placebo
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Intervention_Pharmacological
Drug
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Outcome_Mental
Behavioral effects
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Outcome_Mental
ethological playroom observation
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Outcome_Mental
Aberrant Behavior Checklist ratings
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Outcome_Mental
activating influence
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Outcome_Mental
stereotypic behavior
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Outcome_Mental
" change toys , " " locomote , " and " talk . "
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Participant_Sample-size
14
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Participant_Condition
outpatient autistic
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Participant_Sample-size
Fourteen
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Participant_Sample-size
12
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Participant_Condition
infantile autism full syndrome
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Participant_Sample-size
2
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Participant_Condition
atypical pervasive developmental disorder
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Participant_Age
5 and 13