63284
document
Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community . BACKGROUND HIV-infected prisoners have a high prevalence of alcohol use disorders and commonly relapse to alcohol soon after release to the community which is linked to high morbidity , poor antiretroviral therapy ( ART ) adherence and increased sexual risk-taking behaviors . Extended-release naltrexone ( XR-NTX ) effectively reduces relapse to alcohol in alcohol dependent persons , yet it remains unexamined among criminal justice system ( CJS ) populations transitioning to the community . METHODS A randomized double-blind , placebo-controlled trial of XR-NTX to improve HIV treatment outcomes via reducing relapse to alcohol use after prison release for HIV-infected hazardous drinking and alcohol dependent prisoners is discussed . RESULTS Acceptability of study participation is high with 86 % of those referred who met eligibility criteria and 85 % of those who were able to receive injections prior to release accepted injections , yet important implementation issues are identified and addressed during the study and are discussed in this paper . CONCLUSION Medication-assisted therapies for prevention of relapse to alcohol use for CJS populations transitioning to the community , especially for HIV-infected patients , are urgently needed in order to reduce alcohol relapse after release and improve HIV treatment outcomes and contribute to improved individual and public health .
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
extended-release naltrexone
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Intervention_Pharmacological
Extended-release naltrexone ( XR-NTX )
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
XR-NTX
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Outcome_Physical
relapse to alcohol
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Outcome_Physical
relapse to alcohol
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Outcome_Physical
relapse to alcohol
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Outcome_Other
Acceptability
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Outcome_Physical
alcohol relapse
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Outcome_Physical
HIV treatment outcomes
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Outcome_Physical
individual and public health .
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Participant_Condition
alcohol dependent
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Participant_Condition
hazardous drinking prisoners
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Participant_Condition
HIV
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Participant_Condition
transitioning to the community
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Participant_Condition
HIV-infected prisoners
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Participant_Condition
alcohol dependent prisoners
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Participant_Condition
HIV-infected