63197
document
Effects of water extracts of Graptopetalum paraguayense on blood pressure , fasting glucose , and lipid profiles of subjects with metabolic syndrome . This study was aimed to investigate the effects of water extracts of Graptopetalum paraguayense ( WGP , 4 g/d ) on blood pressure , blood glucose level , and lipid profiles in subjects with metabolic syndrome ( MS ) . Participants with MS ( n = 54 ) were randomly assigned to the placebo ( n = 28 ) and WGP groups ( n = 26 ) , and the intervention was administered for 12 weeks . Systolic blood pressure ( SBP ) , diastolic blood pressure ( DBP ) , fasting glucose ( FG ) , lipid profiles ( total cholesterol ( TC ) , triglyceride ( TG ) , low density lipoprotein cholesterol ( LDL-C ) , and high density lipoprotein ( HDL-C ) ) , and antioxidant enzymes activities ( catalase ( CAT ) , superoxide dismutase ( SOD ) , and glutathione peroxidase ( GPx ) ) were measured . Forty-two subjects completed the study ( placebo , n = 19 ; WGP , n = 23 ) . FG , SBP , and LDL-C levels were significantly lower and HDL-C level and antioxidant enzymes activities ( CAT and SOD ) were significantly higher after WGP supplementation . Blood pressure , FG , and lipid profiles were significantly correlated with antioxidant enzymes activities after supplementation ( P < 0.05 ) . The present study demonstrated a significant reduction in blood pressure , blood glucose , and lipid profiles and an increase in antioxidant enzymes activities in subjects with MS after WGP supplementation . Taken together , the antioxidative capacity of WGP might exert a beneficial effect on MS . This trial is registered with ClinicalTrials.gov NCT01463748 .
63198
Intervention_Pharmacological
water extracts of Graptopetalum paraguayense
63199
Intervention_Pharmacological
water extracts of Graptopetalum paraguayense ( WGP , 4 g/d
63200
Intervention_Control
placebo
63201
Intervention_Pharmacological
WGP
63202
Intervention_Control
placebo
63203
Intervention_Pharmacological
WGP
63204
Intervention_Pharmacological
WGP
63205
Intervention_Control
WGP
63206
Outcome_Physical
blood pressure
63207
Outcome_Physical
fasting glucose
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Outcome_Physical
lipid profiles
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Outcome_Physical
blood pressure
63210
Outcome_Physical
blood glucose level
63211
Outcome_Physical
lipid profiles
63212
Outcome_Physical
Systolic blood pressure ( SBP )
63213
Outcome_Physical
diastolic blood pressure ( DBP ) , fasting glucose ( FG )
63214
Outcome_Physical
lipid profiles
63215
Outcome_Physical
total cholesterol ( TC )
63216
Outcome_Physical
triglyceride ( TG )
63217
Outcome_Physical
low density lipoprotein cholesterol ( LDL-C )
63218
Outcome_Physical
high density lipoprotein ( HDL-C )
63219
Outcome_Physical
antioxidant enzymes
63220
Outcome_Physical
FG
63221
Outcome_Physical
SBP
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Outcome_Physical
LDL-C levels
63223
Outcome_Physical
HDL-C level
63224
Outcome_Physical
antioxidant enzymes activities
63225
Outcome_Physical
Blood pressure
63226
Outcome_Physical
FG
63227
Outcome_Physical
lipid profiles
63228
Outcome_Physical
blood pressure
63229
Outcome_Physical
blood glucose
63230
Outcome_Physical
lipid profiles
63231
Outcome_Physical
antioxidant enzymes activities
63232
Participant_Condition
subjects with metabolic syndrome
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Participant_Condition
subjects with metabolic syndrome ( MS ) . Participants with MS
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Participant_Sample-size
n = 54
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Participant_Sample-size
Forty-two subjects
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Participant_Sample-size
n = 19
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Participant_Sample-size
n = 23
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Participant_Condition
subjects with MS