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document
Evaluating erectile dysfunction : oral sildenafil versus intracavernosal injection of papaverine . BACKGROUND Intracavernosal injection of vasoactive drugs is an established method of evaluating erectile dysfunction . However , it is invasive and may be associated with pain and priapism . We investigated the use of oral sildenafil as a possible substitute for intracavernosal agents . METHODS Men with erectile dysfunction were randomized into two groups of 25 each . One group of 25 men received injection papaverine initially followed by oral sildenafil , and another 25 received oral sildenafil followed by injection papaverine . Genital self-stimulation was used in both the groups . Penile length and circumference as well as angle of erection , before and after each medication , were recorded . Two days later , the intervention arms were crossed over . Subjective responses were obtained . The effect of medication on each outcome variable was studied by using analysis of variance models in relation to patient , period and medication . RESULTS There was statistically significant improvement from the baseline value in both the arms , i.e injection papaverine and oral sildenafil ( p < 0.001 , p < 0.001 , respectively ) for both penile length and circumference . No significant difference was observed between the two medications in the outcome measures . CONCLCUSION : Oral sildenafil was as effective as injection papaverine in evaluating erectile dysfunction .
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Intervention_Pharmacological
injection papaverine initially followed by oral sildenafil
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Intervention_Pharmacological
oral sildenafil followed by injection papaverine
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Outcome_Other
Evaluating
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Outcome_Physical
Penile length and circumference as well as angle of erection
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Outcome_Other
Subjective responses
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Outcome_Other
analysis of variance models
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Outcome_Physical
penile length and circumference
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Participant_Condition
erectile dysfunction :
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Participant_Sex
Men
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Participant_Condition
erectile dysfunction
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Participant_Sample-size
two groups of 25 each
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Participant_Sample-size
25
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Participant_Sex
men
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Participant_Condition
erectile dysfunction