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Aminocaproic acid versus prednisone for the treatment of traumatic hyphema . A randomized clinical trial . One hundred twelve patients who sustained hyphema after blunt trauma were enrolled in a double-blind randomized clinical trial to determine the relative efficacies of aminocaproic acid ( Amicar ) and systemic prednisone for reducing the rate of secondary hemorrhage . Fifty-six patients received an oral dosage of 50 mg/kg of aminocaproic acid every 4 hours for 5 days , up to a maximum of 30 g daily , and 56 patients received an oral dosage of 40 mg of prednisone daily ( adjusted for weight ) in two divided doses . Placebo pills and liquids were given to each patient to mask the treatment schedules . There were no statistically significant differences between the patient populations for any demographic or clinical characteristic ( e.g. , visual acuity , intraocular pressure [ IOP ] , initial hyphema size ) measured in the study . Blacks comprised 53 % of the study population , and the mean age of the patients was 23.5 years . Four patients in each of the treatment groups experienced a secondary hemorrhage ; the rebleed rate was 7.1 % in each group .
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Intervention_Pharmacological
Aminocaproic acid
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Intervention_Pharmacological
prednisone
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Intervention_Pharmacological
aminocaproic acid ( Amicar )
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Intervention_Pharmacological
systemic prednisone
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Intervention_Pharmacological
aminocaproic acid
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Intervention_Pharmacological
prednisone
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Intervention_Control
Placebo
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Outcome_Physical
rate of secondary hemorrhage
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Outcome_Physical
visual acuity
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Outcome_Physical
intraocular pressure [ IOP ]
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Outcome_Physical
initial hyphema size
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Outcome_Physical
secondary hemorrhage
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Outcome_Physical
rebleed rate
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Participant_Condition
traumatic hyphema
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Participant_Sample-size
One hundred twelve
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Participant_Condition
sustained hyphema after blunt trauma
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Participant_Age
mean age of the patients was 23.5 years