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document
Metformin therapy improves ovulatory rates , cervical scores , and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome . OBJECTIVE To evaluate the effect of metformin therapy on hyperandrogenism , insulin resistance , cervical scores , ovulation , and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome ( PCOS ) . DESIGN Prospective , randomized , double-blind , placebo-controlled study . SETTING Infertility clinic of a tertiary referral center . PATIENT ( S ) Fifty-six women with clomiphene citrate-resistant PCOS . INTERVENTION ( S ) Two cycles of oral metformin therapy ( 850 mg , twice daily ) in group I and placebo therapy ( twice daily ) in group II . Clomiphene citrate ( 100 mg/day ) on cycle days 3-7 of the second cycle in both groups . MAIN OUTCOME MEASURE ( S ) Insulin , T , DHEAS , FSH , LH , body mass index ( BMI ) , waist-to-hip ratio , endometrial thickness , cervical score , ovulation , and pregnancy rates in clomiphene-induced cycles after metformin therapy . RESULT ( S ) Metformin therapy resulted in a significant decrease in total T , LH level , LH/FSH ratio , insulin resistance , and mean BMI . No difference in waist-to-hip ratio , DHEAS level , and fasting insulin level was observed . Clomiphene citrate induction resulted in higher ovulation rates and thicker endometrium in the metformin group than in the placebo group . There was higher cumulative pregnancy rate in the metformin group ; however , there was no significant difference in the pregnancy rate between the two groups . CONCLUSION ( S ) Metformin therapy not only decreases hyperandrogenism and insulin resistance but also improves ovulation rates , cervical scores , and pregnancy rates in clomiphene citrate-resistant women with PCOS .
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Intervention_Pharmacological
Metformin therapy
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Intervention_Pharmacological
metformin therapy
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
oral metformin therapy
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Intervention_Control
placebo therapy
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Intervention_Pharmacological
Clomiphene citrate
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Intervention_Pharmacological
metformin
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Intervention_Pharmacological
Metformin
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Intervention_Pharmacological
metformin
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Intervention_Control
placebo
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Intervention_Pharmacological
Metformin
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Outcome_Physical
ovulatory rates , cervical scores , and pregnancy rates
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Outcome_Physical
Insulin , T , DHEAS , FSH , LH , body mass index ( BMI ) , waist-to-hip ratio , endometrial thickness , cervical score , ovulation , and pregnancy rates
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Outcome_Physical
total T , LH level , LH/FSH ratio , insulin resistance , and mean BMI .
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Outcome_Physical
waist-to-hip ratio , DHEAS level , and fasting insulin level
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Outcome_Physical
ovulation rates and thicker endometrium
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Outcome_Physical
cumulative pregnancy rate
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Outcome_Physical
pregnancy rate
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Outcome_Physical
hyperandrogenism and insulin resistance
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Outcome_Physical
ovulation rates , cervical scores , and pregnancy rates
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Participant_Condition
clomiphene citrate-resistant women with polycystic ovary syndrome .