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document
Effect of exercise , training , and glycogen availability on IL-6 receptor expression in human skeletal muscle . The cytokine interleukin-6 ( IL-6 ) exerts it actions via the IL-6 receptor ( IL-6R ) in conjunction with the ubiquitously expressed gp130 receptor . IL-6 is tightly regulated in response to exercise , being affected by factors such as exercise intensity and duration , as well as energy availability . Although the IL-6 response to exercise has been extensively studied , little is known about the regulation of the IL-6R response . In the present study , we aimed to investigate the effect of exercise , training , and glycogen availability , factors known to affect IL-6 , on the regulation of gene expression of the IL-6R in human skeletal muscle . Human subjects performed either 10 wk of training with an acute exercise bout before and after the training period , or a low-glycogen vs. normal-glycogen acute exercise trial . The IL-6R mRNA response was evaluated in both trials . In response to acute exercise , an increase in IL-6R mRNA levels was observed . Neither training nor intramuscular glycogen levels had an effect on the IL-6R mRNA response to exercise . However , after 10 wk of training , the skeletal muscle expressed a higher mRNA level of IL-6R compared with before training . The present study demonstrated that the IL-6R gene expression levels in skeletal muscle are increased in response to acute exercise , a response that is very well conserved , being affected by neither training status nor intramuscular glycogen levels , as opposed to IL-6 . However , after the training period , IL-6R mRNA production was increased in skeletal muscle , suggesting a sensitization of skeletal muscle to IL-6 at rest .
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Intervention_Physical
exercise , training
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Intervention_Physical
glycogen availability
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Intervention_Physical
exercise
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Intervention_Physical
exercise , training
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Intervention_Physical
glycogen availability
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Intervention_Physical
10 wk of training with an acute exercise bout before and after the training period
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Intervention_Physical
normal-glycogen acute exercise trial
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Intervention_Physical
training
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Outcome_Physical
IL-6R mRNA response
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Outcome_Physical
IL-6R mRNA levels
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Outcome_Physical
IL-6R mRNA response
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Outcome_Physical
mRNA level of IL-6R
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Outcome_Physical
IL-6R gene expression levels
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Outcome_Physical
training status
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Outcome_Physical
intramuscular glycogen levels
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Outcome_Physical
IL-6R mRNA production
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Participant_Condition
human skeletal muscle .