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Predictors of local adverse effects caused by topical tretinoin cream 0·1 % in the Veterans Affairs Topical Tretinoin Chemoprevention trial . BACKGROUND Topical tretinoin is commonly prescribed , but its frequent adverse effects are barriers to use . Predictors of resistance or susceptibility to retinoid irritation are not known . OBJECTIVE To identify baseline patient characteristics associated with adverse effects of topical tretinoin . METHODS This cohort study used data collected from 324 participants in the Veterans Affairs Topical Tretinoin Chemoprevention trial who were randomized to apply tretinoin cream on the face and ears . Univariate and multivariate logistic regression models were used to examine the associations between baseline characteristics and local adverse effects . RESULTS One hundred and ninety-seven patients ( 61 % of those randomized to tretinoin ) reported local adverse effects within 6 months . Clinical signs of severe photodamage at baseline [ odds ratio ( OR ) 0·15 , 95 % confidence interval ( CI ) 0·04-0·54 ] and history of acne ( OR 0·46 , 95 % CI 0·27-0·77 ) were associated with a decreased risk of adverse effects to tretinoin . The use of other topical medications at enrolment ( OR 1·88 , 95 % CI 1·15-3·08 ) predicted an increase in adverse effects . CONCLUSIONS In this study population , the common indications of topical tretinoin treatment were associated with lower risks of adverse effects . The concurrent use of other topical medications may worsen irritation caused by tretinoin .
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Intervention_Pharmacological
tretinoin
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Outcome_Adverse-effects
reported local adverse effects
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Outcome_Physical
of
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Outcome_Adverse-effects
severe photodamage
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Outcome_Physical
and history of acne
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Outcome_Adverse-effects
risk of adverse effects
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Outcome_Adverse-effects
increase in adverse
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Outcome_Adverse-effects
lower risks of adverse
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Participant_Condition
the Veterans Affairs Topical Tretinoin Chemoprevention trial
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Participant_Sample-size
324