1488
document
Effects of captopril and enalapril on electroencephalogram and cognitive performance in healthy volunteers . OBJECTIVE Captopril and enalapril have been reported to influence cognitive functions and quality of life in hypertensive patients . METHODS The effects of captopril ( 12.5 mg and 25 mg ) and enalapril ( 5 mg and 10 mg ) administered during 7-day periods on electroencephalogram ( EEG ) , cognitive functions , and subjective assessments were investigated in healthy males . RESULTS Neither captopril nor enalapril influenced EEG and cognitive functions compared with placebo . Captopril 12.5 mg decreased subjective activity compared with placebo . Enalapril did not alter subjective ratings . Both systolic and diastolic blood pressure were significantly lower after administration of captopril 25 mg , whereas blood pressure was unaffected by enalapril compared with placebo . CONCLUSION Our results suggest that central effects of captopril and enalapril were minor and not constant in young healthy men .
1489
Intervention_Pharmacological
captopril
1490
Intervention_Pharmacological
enalapril
1491
Intervention_Pharmacological
Captopril
1492
Intervention_Pharmacological
enalapril
1493
Intervention_Pharmacological
captopril
1494
Intervention_Pharmacological
enalapril
1495
Intervention_Other
electroencephalogram
1496
Intervention_Pharmacological
Captopril
1497
Intervention_Control
placebo
1498
Intervention_Pharmacological
Enalapril
1499
Intervention_Pharmacological
captopril
1500
Intervention_Pharmacological
enalapril
1501
Intervention_Pharmacological
captopril
1502
Intervention_Pharmacological
enalapril
1503
Outcome_Physical
electroencephalogram and cognitive performance
1504
Outcome_Physical
cognitive functions
1505
Outcome_Physical
quality of life
1506
Outcome_Physical
electroencephalogram ( EEG )
1507
Outcome_Physical
cognitive functions
1508
Outcome_Physical
subjective assessments
1509
Outcome_Physical
EEG
1510
Outcome_Physical
cognitive functions
1511
Outcome_Physical
subjective activity
1512
Outcome_Physical
subjective ratings
1513
Outcome_Physical
systolic and diastolic blood pressure
1514
Outcome_Physical
blood pressure
1515
Participant_Condition
healthy
1516
Participant_Condition
hypertensive
1517
Participant_Condition
healthy
1518
Participant_Sex
males
1519
Participant_Age
young
1520
Participant_Condition
healthy
1521
Participant_Sex
men