6876
document
Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms ? BACKGROUND Rebound acid hypersecretion might occur after treatment with proton pump inhibitors . This study looks for a rebound aggravation of symptoms after short-term treatment with lansoprazole . STUDY Sixty-two patients ( 19 men and 43 women ; mean age , 54 years ; range , 32-77 years ) with heartburn and regurgitation and normal upper endoscopy findings were studied in a randomized , double-blind , placebo-controlled trial with a crossover design . There were two 5-day treatment periods with lansoprazole 60 mg once daily or placebo in random order , separated by a 9-day washout period . Reflux , total , and antacid scores were calculated for each of the treatment periods . Higher scores during the placebo period in the group given lansoprazole first than in the group given placebo first indicated a rebound aggravation of symptoms . RESULTS The mean symptom scores during the placebo period in the groups given lansoprazole first and placebo first were as follows : reflux score , 21.5 and 17.6 , respectively ( not significant ) ; total score , 11.2 and 10.3 , respectively ( not significant ) ; and antacid score , 8.2 and 7.2 , respectively ( not significant ) . CONCLUSIONS There is no indication of a rebound aggravation of symptoms 12 to 14 days after a 5-day treatment with lansoprazole 60 mg once daily in patients with reflux symptoms .
6877
Intervention_Pharmacological
proton pump inhibitors
6878
Intervention_Pharmacological
proton pump inhibitors
6879
Intervention_Pharmacological
lansoprazole .
6880
Intervention_Control
placebo-controlled
6881
Intervention_Pharmacological
lansoprazole 60 mg once daily
6882
Intervention_Control
placebo
6883
Intervention_Control
placebo
6884
Intervention_Pharmacological
lansoprazole
6885
Intervention_Control
placebo
6886
Intervention_Pharmacological
lansoprazole
6887
Outcome_Physical
Reflux , total , and antacid scores
6888
Outcome_Physical
symptom scores
6889
Outcome_Physical
reflux score
6890
Outcome_Physical
total score
6891
Outcome_Physical
antacid score
6892
Participant_Condition
Sixty-two patients ( 19 men and 43 women ; mean age , 54 years ; range , 32-77 years ) with heartburn and regurgitation and normal upper endoscopy findings
6893
Participant_Condition
patients with reflux symptoms .