35394
document
Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones . OBJECTIVE To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol , a daidzein metabolite . METHOD A randomized , double-blind , placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women . After taking take 135 mg of isoflavones daily for 1 week , the women in the study group were assigned to the equol-producing ( EP ) or the non-EP group according to the presence or absence of equol in their urine . Menopausal symptoms were evaluated using a modified Kupperman Index . RESULT Compared with the placebo group , the scores for hot flashes and excessive sweating were significantly reduced after 3 months , and the scores for weakness , palpitations , limb paresthesia , and total symptoms after 6 months , in the EP group only . CONCLUSIONS Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol .
35395
Intervention_Pharmacological
soy isoflavones
35396
Intervention_Pharmacological
soy isoflavones
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Intervention_Control
placebo-controlled
35398
Intervention_Pharmacological
isoflavones
35399
Intervention_Control
placebo
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Intervention_Pharmacological
Isoflavone supplementation
35401
Outcome_Physical
menopausal symptoms
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Outcome_Physical
hot flashes and excessive sweating
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Outcome_Physical
weakness
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Outcome_Physical
palpitations
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Outcome_Physical
limb paresthesia
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Outcome_Physical
total symptoms
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Outcome_Physical
menopausal symptoms
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Participant_Condition
menopausal symptoms in women treated with soy isoflavones .
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Participant_Condition
women who do and who do not produce equol
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Participant_Condition
96 healthy menopausal women .