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document
[ Efficacy and immune memory of plasma-derived hepatitis B vaccine 11 years after primary immunization ] . OBJECTIVE To evaluate the long-term efficacy of hepatitis B vaccine 10 years after primary immunization to provide scientific basis for the time of revaccination . METHODS The study was strictly designed with randomization , double-blinding , and placebo-controlled method to observe the efficacy and immune memory 11 years following hepatitis B vaccination . RESULTS Immunogenicity and protective rate of vaccine were still kept well 11 years after immunization with a protective rate against HBV infection of 73.5 % . But , there was no significant difference in HBV infection rates between vaccine group and placebo-controlled group ( 7.89 % vs. 13.25 % , P > 0.1 ) nine to 11 years following immunization . There still existed immune memory 11 years after immunization , but it was significantly weaker than that within the first 10 years after immunization . CONCLUSION The efficacy of the vaccine had begun to drop 11 years after immunization , which should be followed up further to reach a clear conclusion .
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Intervention_Pharmacological
plasma-derived hepatitis B vaccine
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Intervention_Pharmacological
hepatitis B vaccine
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
hepatitis B vaccination
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Outcome_Other
Efficacy
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Outcome_Physical
immune memory
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Outcome_Other
long-term efficacy
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Outcome_Physical
immune memory
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Outcome_Physical
Immunogenicity and protective rate of vaccine
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Outcome_Physical
protective rate
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Outcome_Physical
HBV infection rates
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Outcome_Physical
immune memory
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Outcome_Other
efficacy
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Participant_Condition
hepatitis B vaccine 11 years after primary immunization ]
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Participant_Condition
hepatitis B vaccine 10 years after primary immunization