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document
Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly . OBJECTIVE The effectiveness of influenza vaccination in preventing illness is lower in the elderly ; this is why the ability of Lactobacillus plantarum CECT 7315/7316 to stimulate the response to influenza vaccination in elderly was evaluated . RESEARCH METHODS AND PROCEDURES A randomized , double-blind , placebo-controlled human trial including 60 institutionalized volunteers aged 65-85 years was performed . All the volunteers were vaccinated with a trivalent influenza vaccine ( A/Wisconsin/67/2005 NYMC X-161B ( H3N2 ) , A/Solomon Islands/3/2006 ( H1N1 ) and B/Malaysia/2506/2004 ) for the Spanish vaccine campaign 2006/2007 . The consumption of the probiotic began between three and four months after the vaccination . Volunteers were randomly assigned to one of three following groups : group A ( receiving 5*10 ( 9 ) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk ) , group B ( receiving 5*10 ( 8 ) cfu/day of L. plantarum CECT 7315/7316 in 20 g powdered skim milk ) and group C or placebo ( 20 g powered skim milk ) . The participants consumed the probiotic during 3 months . RESULTS The consumption of L. plantarum CECT 7315/7316 during 3 months after influenza vaccination increased the levels of influenza-specific IgA and IgG antibodies . Moreover , a trend towards an increase in influenza-specific IgM antibodies was also observed . CONCLUSION L. plantarum CECT7315/7316 has an immunostimulating effect and could be used to improve the response to influenza vaccination in elderly .
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Intervention_Pharmacological
Lactobacillus plantarum CECT7315
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Intervention_Pharmacological
CECT7316
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Intervention_Pharmacological
influenza vaccination
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Intervention_Pharmacological
influenza vaccination
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Intervention_Pharmacological
Lactobacillus plantarum CECT 7315/7316
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Intervention_Pharmacological
influenza vaccination
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
trivalent influenza vaccine ( A/Wisconsin/67/2005 NYMC X-161B ( H3N2 )
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Intervention_Pharmacological
A/Solomon Islands/3/2006 ( H1N1 )
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Intervention_Pharmacological
B/Malaysia/2506/2004 )
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Intervention_Pharmacological
plantarum CECT 7315/7316
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Intervention_Pharmacological
plantarum CECT 7315/7316
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Intervention_Control
placebo
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Intervention_Control
powered skim milk
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Intervention_Pharmacological
plantarum CECT 7315/7316
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Intervention_Pharmacological
influenza vaccination
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Intervention_Pharmacological
plantarum CECT7315/7316
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Intervention_Pharmacological
influenza vaccination
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Outcome_Physical
immunoglobulin production
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Outcome_Physical
stimulate the response to influenza vaccination
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Outcome_Physical
levels of influenza-specific IgA and IgG antibodies .
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Outcome_Physical
influenza-specific IgM antibodies
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Participant_Condition
influenza vaccination
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Participant_Age
elderly
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Participant_Condition
influenza vaccination
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Participant_Age
elderly
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Participant_Sample-size
60
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Participant_Condition
institutionalized volunteers
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Participant_Age
aged 65-85 years