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document
Pre-exposure studies with purified chick embryo cell culture rabies vaccine and human diploid cell vaccine : serological and clinical responses in man . Clinical reactions and neutralizing antibody responses to six pre-exposure regimens of purified chick embryo cell culture rabies vaccine ( PCECV ) and human diploid cell strain rabies vaccine ( HDCSV ) were studied in 177 volunteers . Antibody kinetics , height of the response and persistence of antibody over two years were virtually identical after PCECV and HDCSV . An antibody response was detected in all subjects on day 14 when the highest titres were found after two intramuscular ( i.m . ) 1.0 ml doses of a schedule of immunization on days 0 , 7 and 21 . In comparison , a schedule of immunization on days 0 , 28 and 56 ultimately evoked the highest titres 21 days after the final injection , but antibody persisted equally well over two years with either schedule . Neutralizing antibody titres were lower after intradermal ( i.d . ) vaccination with 0.1 ml compared to 1.0 ml i.m . on days 0 , 7 and 21 , but when given on days 0 , 28 and 56 the responses were comparable . Three subjects with a personal or family history of atopy developed urticarial lesions after PCECV . Both vaccines were otherwise well tolerated .
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Intervention_Pharmacological
purified chick embryo cell culture rabies vaccine
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Intervention_Pharmacological
human diploid cell vaccine
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Intervention_Pharmacological
purified chick embryo cell culture rabies vaccine ( PCECV )
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Intervention_Pharmacological
human diploid cell strain rabies vaccine ( HDCSV )
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Intervention_Pharmacological
PCECV
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Intervention_Pharmacological
HDCSV
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Intervention_Pharmacological
PCECV
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Outcome_Other
response
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Outcome_Other
persistence of antibody over two years
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Outcome_Mental
antibody response
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Outcome_Other
titres 21 days after the final injection
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Outcome_Other
Neutralizing
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Outcome_Physical
antibody titres
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Outcome_Physical
urticarial lesions
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Participant_Sex
man
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Participant_Sample-size
177