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document
Assessment of radiotherapy combined with adjuvant chemotherapy in the treatment of patients with advanced nasopharyngeal carcinoma : a prospective study . PURPOSE To explore the clinical efficacy of radiotherapy combined with concurrent combination chemotherapy in the treatment of patients with advanced nasopharyngeal carcinoma ( NPC ) . METHODS Two hundred patients with stage III/IV NPC were randomly allocated into the treatment group ( N=100 ) and the control group ( N=100 ) . Patients in the control group received conventional fractionated radiotherapy , while patients in the treatment group received conventional fractionated radiotherapy combined with concurrent combination chemotherapy with cisplatin and 5-fluorouracil ( 5-FU ) . Short-term efficacy , radiotherapy toxicity , shortand long-term survival were compared . RESULTS The short-term response rate of the treatment group was 96 % , which was significantly higher than that of the control group ( 87 % , p < 0.05 ) . The local radiation toxicity of the treatment group was similar to that of the control group p > 0.05 ) , but the hematological and gastrointestinal toxicities were significantly higher in the treatment group p < 0.05 ) . The 1- , 3- and 5-year overall survival rates were 87 , 80 , and 76 % , respectively , in the treatment group and 74 , 64 , and 51 % , respectively , in the control group , significantly favoring the treatment group p < 0.05 ) . CONCLUSION Radiotherapy with concurrent combination chemotherapy can improve the prognosis of patients with advanced NPC but at the cost of significant toxicity .
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Intervention_Physical
radiotherapy
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Intervention_Pharmacological
combined with adjuvant chemotherapy
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Intervention_Physical
radiotherapy
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Intervention_Pharmacological
combined with concurrent combination chemotherapy
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Intervention_Control
conventional fractionated radiotherapy
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Intervention_Physical
conventional fractionated radiotherapy
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Intervention_Pharmacological
combined with concurrent combination chemotherapy with cisplatin and 5-fluorouracil ( 5-FU )
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Intervention_Pharmacological
Radiotherapy with concurrent combination chemotherapy
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Outcome_Other
efficacy
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Outcome_Other
Short-term efficacy
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Outcome_Adverse-effects
radiotherapy toxicity
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Outcome_Mortality
shortand long-term survival
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Outcome_Other
short-term response
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Outcome_Adverse-effects
local radiation toxicity
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Outcome_Adverse-effects
hematological and gastrointestinal toxicities
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Outcome_Mortality
overall survival rates
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Outcome_Physical
prognosis
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Outcome_Adverse-effects
toxicity .
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Participant_Condition
patients with advanced nasopharyngeal carcinoma
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Participant_Condition
patients with advanced nasopharyngeal carcinoma ( NPC )
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Participant_Sample-size
Two hundred patients
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Participant_Condition
stage III/IV NPC
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Participant_Condition
advanced NPC