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document
Effects of fish oil supplementation on markers of the metabolic syndrome . OBJECTIVE To investigate whether fish oil affects cardiovascular risk factors during the adolescent growth spurt . STUDY DESIGN A total of 78 boys age 13-15 years with a mean body fat percentage of 30 % +/-9 % were randomly assigned to consume fish oil ( providing 1.5 g of n-3 long-chain polyunsaturated fatty acid/day ) or vegetable oil ( control ) for 16 weeks . The oils were included in bread . RESULTS After the intervention , the red blood cell ( RBC ) content of eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ) were 1.2 % +/-0.5 % and 6.7 % +/-1.6 % , respectively , in the those receiving fish oil ( FO group ) , compared with 0.6 % +/-0.3 % and 4.1 % +/-0.9 % in the control group . Systolic blood pressure ( SBP ) was 3.8+/-1.4 mm Hg lower ( P < .006 ) and diastolic blood pressure ( DBP ) was 2.6+/-1.1 mm Hg lower ( P < .01 ) in the FO group compared with the control group . Plasma triacylglycerol ( TAG ) concentration and insulin sensitivity were unaffected by either of the treatments . Plasma high-density lipoprotein ( HDL ) and non-HDL cholesterol were increased by 5 % and 7 % , respectively , in the FO group , and by 2 % and 0 % in the control group ( P < .01-.02 ) . The changes in RBC EPA content were inversely correlated with the changes in SBP and DBP and directly correlated with the increases in HDL cholesterol and non-HDL cholesterol concentrations . No association was seen between RBC EPA and plasma TAG concentration or insulin sensitivity . CONCLUSION Fish oil improves BP in normotensive and normolipidemic slightly overweight adolescent boys .
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Intervention_Pharmacological
fish oil supplementation
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Intervention_Pharmacological
fish oil
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Intervention_Pharmacological
fish oil
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Intervention_Pharmacological
long-chain polyunsaturated fatty acid/day )
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Intervention_Pharmacological
vegetable oil
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Intervention_Pharmacological
fish oil ( FO group )
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Intervention_Control
control
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Intervention_Pharmacological
FO
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Intervention_Control
control
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Intervention_Pharmacological
Fish oil
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Outcome_Physical
red blood cell ( RBC )
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Outcome_Physical
eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA )
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Outcome_Physical
Systolic blood pressure ( SBP )
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Outcome_Physical
Plasma triacylglycerol ( TAG ) concentration
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Outcome_Physical
insulin sensitivity
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Outcome_Physical
Plasma high-density lipoprotein ( HDL ) and non-HDL cholesterol
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Outcome_Physical
changes in RBC EPA content
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Outcome_Physical
changes in SBP and DBP
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Outcome_Physical
HDL cholesterol and non-HDL cholesterol concentrations .
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Outcome_Physical
RBC EPA and plasma TAG concentration or insulin sensitivity .
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Outcome_Physical
BP
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Participant_Sample-size
78
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Participant_Age
boys age 13-15 years
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Participant_Condition
mean body fat percentage of 30 % +/-9 %
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Participant_Condition
normotensive and normolipidemic