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document
A randomized controlled trial to evaluate the efficacy of ultrasound-guided laser photocoagulation for treatment of benign thyroid nodules . This randomized controlled study was designed to test the efficacy and safety of percutaneous ultrasound ( US ) -guided laser photocoagulation ( PLP ) for treatment of subjects with compressive symptoms due to benign thyroid nodules and/or at high surgical risk . Twenty six subjects were randomized to the intervention ( no . 13 , age 68+/-3 yr , mean+/-SEM ) or observation ( no . 13 , age 71+/-2 yr ) groups . In the control group , the volume of nodules did not significantly change over the 30 week period of observation . In the intervention group , median nodule volume at baseline was 8.2 ml ( range 2.8-26.9 ) and was not significantly different from that of the control group . Nodules decreased significantly ( p < 0.0001 ) by 22 % after 2 weeks ( 6.5 ml ; range 2.4-16.7 ) and by 44 % after 30 weeks ( 4.6 ml ; range 0.69-14.2 ) . Energy given was correlated ( p < 0.05 ) with the reduction of thyroid nodule volume . All patients tolerated the treatment well and reported relief from compressive and cosmetic complaints ( p < 0.05 ) . At the time of enrolment 7/13 ( 54 % ) and 6/13 ( 46 % ) of patients in the intervention and control groups , respectively , had sub clinical hyperthyroidism . PLP normalized thyroid function at 6 and 30 weeks after treatment . In conclusion , PLP is a promising safe and effective procedure for treatment of benign thyroid nodules in patients at high surgical risk .
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Intervention_Surgical
ultrasound-guided laser photocoagulation
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Intervention_Surgical
percutaneous ultrasound ( US ) -guided laser photocoagulation ( PLP )
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Intervention_Surgical
intervention
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Intervention_Control
observation
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Outcome_Other
efficacy
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Outcome_Other
efficacy
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Outcome_Other
safety
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Outcome_Physical
benign thyroid nodules
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Outcome_Physical
volume of nodules
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Outcome_Physical
median nodule volume
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Outcome_Physical
Nodules
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Outcome_Physical
thyroid nodule volume
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Outcome_Physical
compressive and cosmetic complaints
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Outcome_Physical
sub clinical hyperthyroidism
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Outcome_Physical
PLP normalized thyroid function
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Outcome_Other
safe
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Outcome_Other
effective
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Participant_Condition
benign thyroid nodules
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Participant_Condition
compressive symptoms due to benign thyroid nodules and/or at high surgical risk
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Participant_Sample-size
Twenty six
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Participant_Sample-size
13
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Participant_Age
68+/-3 yr
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Participant_Sample-size
13
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Participant_Age
71+/-2 yr
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Participant_Condition
benign thyroid nodules