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document
[ 4 years ' experience with a balloon-expandable endoprosthesis . Experimental and clinical application ] . During a 4-year period of clinical application of the balloon-expandable Palmaz stent , a randomized trial comparing stent implantation and traditional balloon angioplasty of iliac arteries in arterial occlusive disease was started . The first long-term results , recorded after 2 years , indicate statistically significant differences in the complication rate ( after stenting 2/62 and after angioplasty 5/69 ) and patency ( greater than or equal to 70 % of original lumen size upon stent implantation or balloon inflation : 95 % after stenting and 72 % after angioplasty ) . Clinical improvement after 2 years was 89 % after stenting and 70 % after angioplasty . Parallel to the clinical trials , experimental canine artery stenting was performed to evaluate differences in the long-term patency of stents exposed to restricted flow . Significant differences in neointimal healing were found between normally perfused stents and stents with artificially reduced flow : during the total observation period of 6 months the neointimal height was up to 200 % higher in flow-restricted stents , while the histological composition of the neointima was the same as with normally perfused stents .
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Intervention_Surgical
balloon-expandable endoprosthesis .
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Intervention_Surgical
balloon-expandable Palmaz stent
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Intervention_Surgical
stent implantation and traditional balloon angioplasty
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Outcome_Adverse-effects
complication rate
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Outcome_Other
patency
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Outcome_Physical
Clinical improvement
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Outcome_Physical
neointimal healing
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Outcome_Physical
neointimal height
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Outcome_Physical
histological composition of the neointima
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Participant_Condition
[ 4 years ' experience with a balloon-expandable endoprosthesis . Experimental and clinical application ]
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Participant_Condition
iliac arteries in arterial occlusive disease
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Participant_Condition
stenting 2/62
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Participant_Condition
angioplasty 5/69 )
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Participant_Condition
clinical trials