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document
Children with autistic spectrum disorders . I : comparison of placebo and single dose of human synthetic secretin . AIMS To examine the effect of a single dose of human synthetic secretin ( HSS ) on behaviour and communication in children with autism spectrum disorder ( ASD ) using an objective measure of communication and social reciprocity and standardised rating scales . METHODS Randomised , crossover , double blind , and placebo controlled trial of a single intravenous dose of human synthetic secretin ( HSS ) 2 CU/kg . The 62 subjects ( 3-8 years ) were assigned to group 1 ( saline placebo/HSS ) or group 2 ( HSS/saline placebo ) . Diagnosis was confirmed by ADI-R ( Autism Diagnostic Interview-Revised ) algorithm . Severity of symptoms was rated using the CARS ( Childhood Autism Rating Scale ) . Outcome measures included Communication and Symbolic Behavior Scale ( CSBS ) , Ritvo Real-life Rating Scale , weekly Global Rating Scale ( GBRS ) by parents and teachers , and daily log of gastrointestinal symptoms . The communication subscale of the CSBS , specifying communication function , reciprocity , and social-affective signalling was videotaped and scored by a blinded , trained observer . RESULTS Sixty one children completed the study . After randomisation , there were no significant differences in gender , race , age , and parent and teacher GBRS and Ritvo Scale between the two groups . Compared with placebo , secretin treatment was not associated with significant improvement of CSBS standard scores from baseline to 2 or 4 weeks post-infusion . Five children showed clinical improvement in standard scores : two after HSS and three after placebo . There were no significant changes in gastrointestinal symptoms after HSS or saline placebo . CONCLUSIONS A single dose of intravenous human secretin is not effective in changing behaviour and communication in children with ASD when compared to placebo .
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Intervention_Control
placebo
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Intervention_Pharmacological
human synthetic secretin
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Intervention_Pharmacological
human synthetic secretin ( HSS )
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Intervention_Control
placebo
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Intervention_Pharmacological
human synthetic secretin ( HSS )
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Intervention_Pharmacological
( saline placebo/HSS )
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Intervention_Pharmacological
HSS/saline placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
secretin treatment
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Intervention_Pharmacological
HSS
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Intervention_Control
placebo
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Intervention_Pharmacological
HSS
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Intervention_Control
saline placebo
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Intervention_Pharmacological
human secretin
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Intervention_Control
placebo
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Outcome_Mental
Communication and Symbolic Behavior Scale ( CSBS )
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Outcome_Mental
Ritvo Real-life Rating Scale
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Outcome_Mental
weekly Global Rating Scale ( GBRS )
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Outcome_Mental
GBRS
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Outcome_Mental
CSBS standard scores
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Outcome_Physical
gastrointestinal symptoms
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Participant_Condition
Children with autistic spectrum disorders .
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Participant_Condition
children with autism spectrum disorder ( ASD )