79968
document
Tolfenamic acid and caffeine : a useful combination in migraine . Tolfenamic acid is a potent inhibitor of prostaglandin biosynthesis , which has been proved effective in the treatment of acute migraine attacks . The usefulness of caffeine , metoclopramide and pyridoxine as adjuncts to tolfenamic acid was tested in acute migraine attacks in ten patients . A combination of tolfenamic acid ( 200 mg ) with either caffeine ( 100 mg ) , metoclopramide ( 10 mg ) or pyridoxine ( 300 mg ) was given twice to each patient in random order . Thus 60 attacks were treated . The tolfenamic acid-caffeine combination proved the most effective as judged by duration and intensity of attacks , working ability , vigilance , and overall evaluation of the drugs by the patients . Metoclopramide was somewhat better than pyridoxine as an additive .
79969
Intervention_Pharmacological
Tolfenamic acid and caffeine
79970
Intervention_Pharmacological
Tolfenamic acid
79971
Intervention_Pharmacological
caffeine
79972
Intervention_Pharmacological
metoclopramide
79973
Intervention_Pharmacological
pyridoxine
79974
Intervention_Pharmacological
tolfenamic acid
79975
Intervention_Pharmacological
tolfenamic acid
79976
Intervention_Pharmacological
caffeine
79977
Intervention_Pharmacological
metoclopramide
79978
Intervention_Pharmacological
pyridoxine
79979
Intervention_Pharmacological
tolfenamic acid-caffeine combination
79980
Intervention_Pharmacological
Metoclopramide
79981
Intervention_Pharmacological
pyridoxine
79982
Outcome_Physical
migraine
79983
Outcome_Physical
acute migraine attacks
79984
Outcome_Other
duration and intensity of attacks
79985
Outcome_Physical
working ability , vigilance
79986
Outcome_Other
overall evaluation of the drugs
79987
Participant_Condition
migraine
79988
Participant_Condition
migraine