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document
The NORwegian study on DIstrict treatment of ST-elevation myocardial infarction ( NORDISTEMI ) . OBJECTIVES Thrombolysis is the treatment of choice for patients with ST-elevation myocardial infarction ( STEMI ) living in rural areas with long transfer delays to percutaneous coronary intervention ( PCI ) . This trial compares two different strategies following thrombolysis : to transfer all patients for immediate coronary angiography and intervention , or to manage the patients more conservatively . DESIGN The NORwegian study on DIstrict treatment of STEMI ( NORDISTEMI ) is an open , prospective , randomized controlled trial in patients with STEMI of less than 6 hours of duration and more than 90 minutes expected time delay to PCI . A total of 266 patients will receive full-dose thrombolysis , preferably pre-hospital , and then be randomized to either strategy . Our primary endpoint is the one year combined incidence of death , reinfarction , stroke or new myocardial ischaemia . The study is registered with ClinicalTrials.gov , number NCT00161005 . RESULTS By April 2006 , 109 patients have been randomized . Thrombolysis has been given pre-hospital to 52 % of patients . The median transport distance from first medical contact to catheterization laboratory was 155 km ( range 90-396 km ) . Results of the study are expected in 2008 .
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Intervention_Surgical
PCI
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Intervention_Physical
receive
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Intervention_Pharmacological
full-dose thrombolysis
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Outcome_Mortality
combined incidence of death
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Outcome_Physical
reinfarction
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Outcome_Physical
stroke
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Outcome_Physical
new myocardial ischaemia