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document
A comparative study of the effects of local estrogen with or without local testosterone on vulvovaginal and sexual dysfunction in postmenopausal women . INTRODUCTION A significant number of postmenopausal women suffer from distressing problems because of urogenital atrophy secondary to the decline in circulating estrogen levels . Treatment with topical hormones may provide relief in such women when used judiciously . AIM To study the effects of local estrogen with or without local testosterone on urogenital and sexual health in postmenopausal women . METHODS Seventy-five postmenopausal women symptomatic for urogenital atrophy and sexual dysfunction were randomly divided into two study groups and one control group . The women in study group 1 received local estrogen cream ; study group 2 received local estrogen and testosterone cream ; the control group received nonhormonal lubricant KY gel for 12 weeks . The urogenital and sexuality score , along with the vaginal health index and the vaginal maturation index ( VMI ) , was calculated at the beginning of therapy and 12 weeks later . MAIN OUTCOME MEASURES Changes in the urogenital and sexuality score along with vaginal health index and VMI . RESULTS After 12 weeks of therapy , there was a significant improvement in all the four study parameters , which correlated well with the improvement in symptoms of urogenital atrophy and sexual dysfunction in both the study groups as compared with the control group . Improvement in sexuality score was greatest with combined estrogen-androgen therapy . There were no adverse effects and the therapies were well accepted without any compliance issue . CONCLUSION Local estrogen either alone or with androgen is highly effective in relieving symptoms of urogenital atrophy and in improving sexual function in symptomatic postmenopausal women .
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Intervention_Pharmacological
testosterone
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Intervention_Pharmacological
topical hormones
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Intervention_Pharmacological
local testosterone
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Intervention_Pharmacological
received local estrogen cream
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Intervention_Pharmacological
local estrogen and testosterone cream ;
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Intervention_Control
nonhormonal lubricant KY gel for 12 weeks
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Intervention_Pharmacological
Local estrogen
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Outcome_Physical
vulvovaginal and sexual dysfunction
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Outcome_Physical
urogenital and sexual health
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Outcome_Physical
urogenital and sexuality score
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Outcome_Physical
vaginal health index and the vaginal maturation index ( VMI )
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Outcome_Physical
Changes in the urogenital and sexuality score along with vaginal health index and VMI .
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Outcome_Physical
sexuality score
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Outcome_Adverse-effects
adverse effects
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Outcome_Physical
urogenital atrophy
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Outcome_Physical
improving sexual function
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Participant_Condition
vulvovaginal and sexual dysfunction in postmenopausal women .
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Participant_Age
postmenopausal women
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Participant_Condition
postmenopausal women .
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Participant_Condition
Seventy-five postmenopausal women symptomatic for urogenital atrophy and sexual dysfunction
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Participant_Condition
study groups
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Participant_Condition
control group .
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Participant_Condition
symptomatic postmenopausal women .