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document
Epileptogenic activity of folic acid after drug induces SLE ( folic acid and epilepsy ) OBJECTIVE To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects . STUDY DESIGN First a randomised trial , later periconception care including in total 12225 females . RESULTS Of 60 epileptic women with periconceptional folic acid ( 0.8 mg ) -containing multivitamin supplementation , no one developed epilepsy-related side effects during the periconception period . One epileptic woman delivered a newborn with cleft lip and palate . Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin . This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid ( 1 mg ) -containing multivitamin from the 20th week of gestation . She developed status epilepticus and later symptoms of systemic lupus erythematodes . Her pregnancy ended with stillbirth . CONCLUSIONS The epileptic pregnant patient 's autoimmune disease ( probably drug-induced lupus ) could damage the blood-brain barrier , therefore the therapeutic dose ( > or =1 mg ) of folic acid triggered a cluster of seizures . Physiological dose ( < 1 mg ) of folic acid both in healthy and 60 epileptic women , all without any autoimmune disease , did not increase the risk for epileptic seizures .
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Intervention_Pharmacological
folic acid-containing multivitamin supplementation
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Intervention_Pharmacological
periconceptional folic acid
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Intervention_Pharmacological
-containing multivitamin supplementation
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Intervention_Pharmacological
carbamazepine and a folic acid
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Intervention_Pharmacological
-containing multivitamin
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Outcome_Adverse-effects
cluster of seizures
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Outcome_Adverse-effects
status epilepticus
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Outcome_Adverse-effects
symptoms of systemic lupus erythematodes
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Outcome_Mortality
stillbirth
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Outcome_Adverse-effects
cluster of seizures
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Outcome_Physical
risk for epileptic seizures
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Participant_Condition
epileptic women before and during pregnancy