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document
A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans . Consumption of industrial trans fatty acids ( iTFA ) increases LDL cholesterol , decreases HDL cholesterol , and is strongly associated with a higher risk of cardiovascular disease ( CVD ) . However , changes in circulating cholesterol can not explain the entire effect . Therefore , we studied whether iTFA and conjugated linoleic acid ( CLA ) affect markers of inflammation and oxidative stress . Sixty-one healthy adults consumed each of 3 diets for 3 wk , in random order . Diets were identical except for 7 % of energy provided by oleic acid ( control diet ) , iTFA , or CLA . At the end of the 3 wk , we measured plasma inflammatory markers IL-6 , C-reactive protein , tumor necrosis factor receptors I and II ( TNF-RI and -RII ) , monocyte chemotactic protein-1 and E-selectin , and urinary 8-iso-PGF ( 2α ) , a marker of lipid peroxidation . Consumption of iTFA caused 4 % lower TNF-RI concentrations and 6 % higher E-selectin concentrations compared with oleic acid ( control ) and had no significant effect on other inflammatory markers . CLA did not significantly affect inflammatory markers . The urine concentration of 8-iso-PGF ( 2α ) [ geometric mean ( 95 % CI ) ] was greater after the iTFA [ 0.54 ( 0.48 , 0.60 ) nmol/mmol creatinine ] and the CLA [ 1.2 ( 1.1 , 1.3 ) nmol/mmol creatinine ] diet periods than after the control period [ 0.45 ( 0.41 , 0.50 ) nmol/mmol creatinine ; P < 0.05 ] . In conclusion , high intakes of iTFA and CLA did not substantially affect plasma concentrations of inflammatory markers , but they increased the urine 8-iso-PGF ( 2α ) concentration . However , it is unlikely this plays a major role in the mechanism by which iTFA increase the risk of CVD . However , more research is needed to fully understand the implications of these findings .
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Intervention_Pharmacological
trans fatty acids
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Intervention_Pharmacological
industrial trans fatty acids ( iTFA )
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Intervention_Pharmacological
iTFA
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Intervention_Pharmacological
conjugated linoleic acid ( CLA )
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Intervention_Other
diets
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Intervention_Control
oleic acid ( control diet )
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Intervention_Pharmacological
iTFA
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Intervention_Pharmacological
CLA
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Outcome_Physical
markers of inflammation and oxidative stress
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Outcome_Physical
markers of inflammation and oxidative stress
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Participant_Sample-size
Sixty-one
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Participant_Age
adults