76425
document
Effects of pindolol and clopamide on blood lipids in arterial hypertensive patients . The effects of clopamide , pindolol and its combination on plasma lipids in 49 hypertensive patients ( WHO I-II ) , divided into three parallel randomized groups , were studied over a 6 months period . Total cholesterol , triglycerides , HDL and LDL cholesterol fractions were determined twice during an initial 4-week washout phase , and after a 1- , 3- and 6-month active hypotensive drug phase . Patients were instructed to maintain their usual dietary habits . Daily drug doses were adjusted progressively to attain optimal hypotensive effects . In the clopamide monotherapy group , total cholesterol increased significantly ( p less than 0.05 ) ; triglycerides and LDL showed a tendency to increase while for HDL a tendency to decrease was observed . In the pindolol monotherapy group , a significant reduction of triglycerides ( p less than 0.01 ) and a significant increase of HDL cholesterol ( p less than 0.05 ) were recorded . No significant changes in total cholesterol or LDL fraction were observed . Combined pindolol-clopamide therapy decreased total triglycerides ( NS ) , increased HDL significantly ( p less than 0.05 ) and did not influence total cholesterol and LDL fraction . It is concluded that pindolol does not negatively influence blood lipids as the thiazide-type diuretic clopamide does , and that when both drugs are used together , the beta-blocker can probably counterbalance the diuretic-induced negative effects on blood lipids . Accordingly , it is suggested that pindolol could be a more favorable beta-blocker drug to be used on hypertensive subjects with metabolic coronary risk factors .
76426
Intervention_Pharmacological
pindolol
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Intervention_Pharmacological
clopamide
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Intervention_Pharmacological
clopamide
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Intervention_Pharmacological
pindolol
76430
Intervention_Pharmacological
combination on plasma lipids
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Outcome_Physical
blood lipids
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Outcome_Physical
Total cholesterol
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Outcome_Physical
triglycerides
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Outcome_Physical
HDL and LDL cholesterol fractions
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Outcome_Physical
total cholesterol
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Outcome_Physical
triglycerides
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Outcome_Physical
LDL
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Outcome_Physical
HDL
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Outcome_Physical
triglycerides
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Outcome_Physical
HDL cholesterol
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Outcome_Physical
total cholesterol or LDL fraction
76442
Outcome_Physical
total triglycerides ( NS )
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Outcome_Physical
HDL
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Outcome_Physical
total cholesterol and LDL fraction
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Outcome_Physical
blood lipids
76446
Outcome_Physical
blood lipids
76447
Participant_Condition
arterial hypertensive
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Participant_Sample-size
49
76449
Participant_Condition
hypertensive
76450
Participant_Sample-size
three
76451
Participant_Condition
hypertensive
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Participant_Condition
metabolic coronary risk