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document
Is anti-Pseudomonas therapy warranted in acute respiratory exacerbations in children with cystic fibrosis ? A controlled study was designed to clarify the indications for antibiotic therapy in children with advanced cystic fibrosis hospitalized with respiratory exacerbations . Twenty-two children with severe CF and signs of acute lower respiratory infection were randomly assigned to receive either cloxacillin or carbenicillin plus gentamicin administered intravenously for ten days . Other aspects of therapy were constant . The groups were comparable in all respects and Pseudomonas aeruginosa was the predominant sputum pathogen in most patients . Clinical improvement , chest radiograph changes , evidence of airway obstruction , and bacteriologic flora of sputum were no different regardless of the regimen used . These results suggest that the use of anti-Pseudomonas medication in these children may not always be necessary . These observations need to be confirmed by blind-controlled studies in larger numbers of patients with mild as well as severe respiratory involvement .
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Intervention_Pharmacological
cloxacillin
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Intervention_Pharmacological
carbenicillin plus gentamicin
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Outcome_Physical
respiratory exacerbations
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Outcome_Physical
Clinical improvement , chest radiograph changes , evidence of airway obstruction , and bacteriologic flora of sputum
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Participant_Age
children
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Participant_Condition
cystic fibrosis
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Participant_Age
children
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Participant_Condition
advanced cystic fibrosis hospitalized
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Participant_Condition
respiratory exacerbations
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Participant_Sample-size
Twenty-two
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Participant_Age
children
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Participant_Condition
severe CF
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Participant_Condition
acute lower respiratory infection