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document
Efficacy of intravenous granisetron to control nausea and vomiting during multiple cycles of cisplatin-based chemotherapy . The safety and efficacy of granisetron ( 10 micrograms/kg and 40 micrograms/kg ) were evaluated during a second ( n = 393 ) and third ( n = 200 ) cycle of chemotherapy in this multicenter , double-blind , randomized , parallel-group study . Granisetron was administered as a single intravenous dose before the start of cisplatin chemotherapy ( > or = 60 mg/m2 ) . Total control ( no vomiting , no retching , no nausea , and no use of antiemetic rescue medication ) after the first 24 hr following chemotherapy was achieved in 40 % and 49 % of patients in Cycles 2 and 3 , respectively , for the 10 micrograms/kg group , and in 42 % and 38 % of patients in Cycles 2 and 3 , respectively , for the 40 micrograms/kg group . Both dose levels of granisetron were well tolerated . The results demonstrate comparable efficacy between the 10 micrograms/kg and 40 micrograms/kg doses of granisetron in preventing nausea and vomiting during repeat cycles of high-dose cisplatin-based chemotherapy . The results of this study show that granisetron 10 micrograms/kg is safe and well tolerated , and remains effective with repeat cycle use .
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Intervention_Pharmacological
granisetron
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Intervention_Pharmacological
cisplatin-based chemotherapy
91447
Intervention_Pharmacological
granisetron
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Intervention_Pharmacological
Granisetron
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Intervention_Pharmacological
cisplatin chemotherapy
91450
Intervention_Pharmacological
chemotherapy
91451
Intervention_Pharmacological
granisetron
91452
Intervention_Pharmacological
granisetron
91453
Intervention_Pharmacological
cisplatin-based chemotherapy
91454
Intervention_Pharmacological
granisetron
91455
Outcome_Other
Total control
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Outcome_Physical
no vomiting
91457
Outcome_Physical
no retching , no nausea
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Outcome_Physical
no use of antiemetic rescue medication
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Outcome_Physical
dose levels of granisetron
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Outcome_Physical
nausea
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Outcome_Physical
vomiting
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Participant_Condition
multicenter , double-blind , randomized , parallel-group study .
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Participant_Condition
cisplatin chemotherapy ( > or = 60 mg/m2 ) .
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Participant_Condition
high-dose cisplatin-based chemotherapy .