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document
Fasting and meal-stimulated plasma levels of neurotensin in obese patients after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio . The functional role of the jejunum and ileum with regard to peripheral plasma levels of intact neurotensin and NH2-terminal immunoreactivity of neurotensin was studied by using jejunoileal bypass as a model . Plasma levels were measured by radioimmunoassay before and after jejunoileal bypass randomized to different jejunoileal ratios . Seven patients were studied before bypass surgery and 28 were examined after end-to-side jejunoileal bypass with 50 cm intestine in continuity and a 3:1 or 1:3 ratio between the length of the jejunal and ileal segments . Fasting levels of intact neurotensin were unchanged by surgery , whereas levels of NH2-terminal immunoreactivity were higher in bypass patients with a long ileal segment ( 37.5 cm ) than in unoperated patients and in those with a short ileal segment ( 12.5 cm ) . Meal-stimulated levels of intact neurotensin were higher after 1:3 than 3:1 jejunoileal bypass . The levels of NH2-terminal immunoreactivity in patients with a short ileal segment and in controls were lower than in patients with a long ileal segment . The results show that postprandial levels of both intact neurotensin and NH2-terminal immunoreactivity are related to the length of the functioning ileum and that even a difference in length of 25 cm is reflected in the circulating levels of neurotensin .
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Intervention_Surgical
jejunoileal bypass
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Intervention_Surgical
end-to-side jejunoileal bypass with 50 cm intestine
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Outcome_Physical
Fasting levels of intact neurotensin
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Outcome_Physical
NH2-terminal immunoreactivity
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Outcome_Physical
Meal-stimulated levels of intact neurotensin
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Outcome_Physical
levels of NH2-terminal immunoreactivity
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Outcome_Physical
postprandial levels of both intact neurotensin and NH2-terminal immunoreactivity
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Participant_Condition
obese patients after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio
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Participant_Sample-size
Seven patients
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Participant_Condition
bypass surgery
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Participant_Sample-size
28
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Participant_Condition
end-to-side jejunoileal bypass with 50 cm intestine in continuity and a 3:1 or 1:3 ratio between the length of the jejunal and ileal segments