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document
Heat-exercise performance of pyridostigmine-treated subjects wearing chemical protective clothing . Pyridostigmine bromide is currently the pretreatment of choice for operation in a chemical warfare ( CW ) environment . Under CW conditions , subjects are exposed to thermal stress caused by CW protective clothing . This investigation was conducted to determine if pyridostigmine affects various physiological and biophysical parameters of human temperature regulation in subjects wearing CW protective clothing . Pyridostigmine was administered orally in a randomized double-blind cross-over study in four doses of 30 mg every 8 h. An average of 33 % whole blood cholinesterase inhibition was induced in the pyridostigmine treated group 4 h after ingestion of last tablet . The subjects were exposed to 170 min exercise-heat stress ( Tdb = 33 degrees C ; rh = 60 % ) consisting of 60 min in a sitting position and two 50-min walks ( 1.39 m.s-1 , 5 % grade ) separated by 10 min of rest . Non-evaporative heat exchange was significantly higher , -14.0 and -10.6 W.m-2 ( p less than 0.03 ) , for the pyridostigmine-treated subjects . No additional differences were found between treatments in the physiological responses and heat balance parameters at the end of exposure : heart rate ( HR ) was ( mean +/- S.D . ) 154 +/- 16 and 151 +/- 24 bpm , rectal temperature ( Tre ) was 39.0 +/- 0.4 and 38.9 +/- 0.2 degrees C , heat storage over the 2 h of exercise was 62 +/- 15 and 70 +/- 15 W.m-2 , and sweat rate was 832 +/- 185 and 748 +/- 52 g.h-1 , in the pyridostigmine and placebo treatments , respectively . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
pyridostigmine-treated
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Intervention_Pharmacological
Pyridostigmine bromide
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Intervention_Pharmacological
pyridostigmine
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Intervention_Pharmacological
Pyridostigmine
58285
Intervention_Pharmacological
pyridostigmine
58286
Intervention_Pharmacological
pyridostigmine-treated
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Outcome_Physical
Non-evaporative heat exchange
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Participant_Condition
thermal stress