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document
Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine + epinephrine delivery : a dose-finding study . OBJECTIVES The main purpose of this study was to evaluate the dose-dependent anesthetic efficacy of the intraseptal anesthesia ( ISA ) and periodontal ligament anesthesia ( PLA ) obtained with different volumes of 4 % articaine and 1:100,000 epinephrine ( Ar + Ep ) in human mandibular premolars , using a computer-controlled local anesthetic delivery system ( CCLADS ) . The safety profile of Ar + Ep was also studied by investigating the stability of cardiovascular parameters . MATERIAL AND METHODS One hundred and eighty randomly selected healthy volunteers ( ASA I ) entered the single-blinded study to receive 16 mg + 4 μg , 24 mg + 6 μg , and 32 mg + 8 μg of Ar + Ep , obtained with different volumes ( 0.4 , 0.6 , and 0.8 ml , respectively ) , for the ISA and PLA . Success rate , onset , and duration of profound pulpal anesthesia were evaluated by the electrical pulp tester , while the width of the anesthetic field and duration of soft tissue anesthesia were recorded using the pinprick testing . A monitor was used for the measurement of cardiovascular parameters . RESULTS A dose-dependent duration of pulpal and soft tissue anesthesia was obtained only by the ISA . Success rate , duration of both pulpal and soft tissue anesthesia , and its width were significantly better in the ISA compared with the PLA . No significant cardiovascular changes were seen in both groups . CONCLUSIONS It can be suggested that 0.6 and 0.8 ml of 4 % Ar + 1:100,000 Ep , delivered by CCLADS , offer high success rate and effective clinical parameters of ISA as a primary anesthesia . CLINICAL RELEVANCE It seems that dental procedures requiring profound pulpal , bone , and soft tissue anesthesia could be effectively and safely obtained by mentioned anesthetic protocol .
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Intervention_Pharmacological
computer-controlled articaine + epinephrine delivery :
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Intervention_Pharmacological
intraseptal anesthesia ( ISA )
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Intervention_Pharmacological
periodontal ligament anesthesia ( PLA )
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Intervention_Pharmacological
articaine
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Intervention_Pharmacological
epinephrine ( Ar + Ep )
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Intervention_Other
computer-controlled local anesthetic delivery system ( CCLADS )
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Outcome_Other
Efficacy
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Outcome_Other
safety
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Outcome_Other
anesthetic efficacy
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Outcome_Other
safety profile
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Outcome_Other
Success rate , duration of both pulpal and soft tissue anesthesia
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Outcome_Other
width
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Participant_Sample-size
One hundred and eighty
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Participant_Condition
healthy