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document
Plasma dilution and the rate of infusion of Ringer 's solution . Changes in the volume of the fluid space expanded by i.v . infusion of Ringer 's acetate solution have been analysed recently using mathematical models . Data obtained by such analyses allow simulation of the dilution of the plasma volume during infusion of the solution at different rates . To obtain basic kinetic data for such simulations , the plasma dilution-time curves were measured during and after i.v . infusion of Ringer 's solution 25 ml kg-1 over 30 min in 15 healthy male volunteers ( mean age 31 yr ) and over 30 , 45 and 80 min in six females ( mean age 32 yr ) . Based on these experiments , nomograms were constructed from which the rate of infusion of Ringer 's solution and the infusion time required to obtain a defined plasma dilution in both males and females can be estimated together with the infusion rate needed to maintain the dilution at the level reached .
90402
Intervention_Pharmacological
Ringer 's solution
90403
Intervention_Pharmacological
Ringer 's acetate solution
90404
Intervention_Pharmacological
i.v . infusion of Ringer 's solution
90405
Intervention_Pharmacological
Ringer 's solution
90406
Outcome_Physical
Plasma dilution
90407
Outcome_Physical
plasma volume
90408
Outcome_Physical
plasma dilution-time curves
90409
Participant_Sample-size
15
90410
Participant_Condition
healthy
90411
Participant_Sex
male
90412
Participant_Age
31
90413
Participant_Sample-size
six
90414
Participant_Age
32