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document
Digestive enzyme supplementation for autism spectrum disorders : a double-blind randomized controlled trial . To examine the effects of a digestive enzyme supplement in improving expressive language , behaviour and other symptoms in children with Autism Spectrum Disorder . Randomized , double-blind placebo-controlled trial using crossover design over 6 months for 43 children , aged 3-8 years . Outcome measurement tools included monthly Global Behaviour Rating Scales , Additional Rating Scales of other symptoms by parents and therapists , and monthly completion of the Rescorla Language Development Survey . Compared with placebo , treatment with enzyme was not associated with clinically significant improvement in behaviour , food variety , gastrointestinal symptoms , sleep quality , engagement with therapist , or the Language Development Survey Vocabulary or Sentence Complexity Scores . A small statistically significant improvement on enzyme therapy was seen for the food variety scores . No clinically significant effect improvement of autism symptoms with enzyme use was shown with this trial , however , possible effects on improvement in food variety warrants further detailed investigation .
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Intervention_Pharmacological
Digestive enzyme supplementation
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Intervention_Pharmacological
digestive enzyme supplement
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Intervention_Control
placebo-controlled
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Intervention_Control
placebo
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Intervention_Pharmacological
enzyme
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Outcome_Mental
expressive language
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Outcome_Mental
behaviour
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Outcome_Mental
other symptoms
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Outcome_Other
Global Behaviour Rating Scales
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Outcome_Mental
Additional Rating Scales of other symptoms by parents and therapists
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Outcome_Other
monthly completion of the Rescorla Language Development Survey
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Outcome_Mental
significant improvement in behaviour
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Outcome_Mental
food variety
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Outcome_Physical
gastrointestinal symptoms
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Outcome_Mental
sleep quality
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Outcome_Other
engagement with therapist
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Outcome_Other
the Language Development Survey Vocabulary or Sentence Complexity Scores
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Outcome_Other
significant improvement
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Outcome_Physical
autism symptoms
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Outcome_Mental
improvement in food variety
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Participant_Condition
autism spectrum disorders
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Participant_Age
children
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Participant_Condition
Autism Spectrum Disorder .
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Participant_Sample-size
43
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Participant_Age
3-8 years