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document
[ Cooperative study of surgical adjuvant chemotherapy of colorectal carcinoma ( second study ) : 3-year survival after surgery of non-curatively resected patients . Cooperative Study Group of Surgical Adjuvant Chemotherapy of Colorectal Cancer in Japan ] . A prospective randomized study was carried out to evaluate the efficacy of surgical adjuvant chemotherapy for non-curatively resected colorectal carcinoma patients as a collaborative study at 428 institutes in Japan from Jan. , 1984 to Dec. , 1985 . A total of 1,138 patients were entered in this study . All patients were divided according to disease location ( colon or rectum ) and received one of two chemotherapeutic regimens after surgery ( Regimen C : MMC 12 mg/m2 i.v . at operation day and 6 mg/m2 in every 2 months +UFT 600 mg/day p.o. , D : the same dose of MMC + UFT 400 mg/day p.o . ) randomly . 556 cases ( colon carcinoma regimen C : 148 , D : 185 cases , rectal carcinoma regimen C : 94 , D : 129 cases ) were evaluable at this presentation . Three-year-survival rate of histologically confirmed non-curatively resected colon carcinoma patients was higher in the group receiving regimen C than in regimen D. But no significant difference was found among the other groups .
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Intervention_Physical
surgical adjuvant chemotherapy
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Intervention_Physical
surgical adjuvant chemotherapy
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Intervention_Pharmacological
chemotherapeutic regimens
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Intervention_Pharmacological
( Regimen C : MMC
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Intervention_Pharmacological
+UFT
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Intervention_Pharmacological
D : the same dose of MMC + UFT 400 mg/day p.o . ) randomly .
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Intervention_Pharmacological
regimen C
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Intervention_Pharmacological
regimen D.
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Outcome_Mortality
Three-year-survival rate
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Participant_Condition
colorectal carcinoma
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Participant_Condition
non-curatively resected
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Participant_Condition
non-curatively resected colorectal carcinoma patients
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Participant_Condition
collaborative study
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Participant_Sample-size
1,138
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Participant_Sample-size
556
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Participant_Sample-size
148
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Participant_Sample-size
185
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Participant_Sample-size
94
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Participant_Sample-size
129