4672
document
Epidural fentanyl-bupivacaine compared with clonidine-bupivacaine for analgesia in labour . Alpha-adrenergic agonists produce pain relief through an opioid independent mechanism and may be alternatives to opioids for combination with local anaesthetics for analgesia during labour . We studied 41 pregnant women . Epidural block was performed with 75 microg clonidine ( n = 20 ) or 50 microg fentanyl ( n = 21 ) combined with 0.125 % bupivacaine ( 10 mL ) . Maternal vital parameters were measured . Analgesia was evaluated using a visual analogue scale ( VAS ) ; sedation was scored using a five-point scale . There were no differences in maternal vital parameters , fetal heart rate ( FHR ) or Apgar scores between the groups . Analgesia lasted longer in the bupivacaine-clonidine group ( 139.4 +/- 31 min ) compared with the bupivacaine-fentanyl group ( 127.9 +/- 48 min ) ( P = 0.42 ) . Additional analgesic requirement was more often in the fentanyl-bupivacaine group and total bupivacaine requirement was less in the clonidine-bupivacaine group ( 22.5 +/- 12.5 mg vs. 30.9 +/- 12.8 mg ) ( P = 0.04 ) . This small study confirms that this combination of bupivacaine and clonidine provides satisfactory analgesia for first-stage labour , and of longer duration than bupivacaine-fentanyl .
4673
Intervention_Pharmacological
Epidural fentanyl-bupivacaine
4674
Intervention_Pharmacological
clonidine-bupivacaine
4675
Intervention_Pharmacological
clonidine
4676
Intervention_Pharmacological
50 microg fentanyl
4677
Intervention_Pharmacological
combined with 0.125 % bupivacaine
4678
Intervention_Pharmacological
bupivacaine-clonidine
4679
Intervention_Pharmacological
bupivacaine-fentanyl
4680
Intervention_Pharmacological
fentanyl-bupivacaine
4681
Intervention_Pharmacological
clonidine-bupivacaine
4682
Intervention_Pharmacological
bupivacaine
4683
Intervention_Pharmacological
clonidine
4684
Intervention_Pharmacological
bupivacaine-fentanyl
4685
Outcome_Pain
pain relief
4686
Outcome_Physical
Maternal vital parameters
4687
Outcome_Pain
Analgesia
4688
Outcome_Physical
sedation
4689
Outcome_Physical
maternal vital parameters , fetal heart rate ( FHR ) or Apgar scores
4690
Outcome_Pain
Additional analgesic requirement
4691
Outcome_Pain
satisfactory analgesia
4692
Outcome_Other
duration
4693
Participant_Condition
analgesia in labour
4694
Participant_Sample-size
41
4695
Participant_Sex
women