80546
document
Prostaglandin E1 as a hypotensive drug during general anaesthesia . Hypotension induced by prostaglandin E1 ( PGE1 ) infusion ( 100-150 ng/kg/minute ) during halothane anaesthesia to reduce operative blood loss during mastectomy was investigated . PGE1 decreased systolic arterial pressure approximately 34 % from pre-administration values . The duration of induced hypotension was about 75 minutes . When the infusion was stopped , blood pressure returned to within 15 % of the control with 15 minutes . Heart rate did not change significantly during PGE1 infusion ; the pre-ejection period and left ventricular ejection period were shortened . Renal function during the hypotensive period was well maintained . Blood loss during surgery was significantly decreased . These findings suggest that PGE1 can be used safely to control arterial pressure during surgery .
80547
Intervention_Pharmacological
prostaglandin E1 ( PGE1 ) infusion
80548
Intervention_Pharmacological
halothane anaesthesia
80549
Outcome_Physical
Hypotension
80550
Outcome_Physical
systolic arterial pressure
80551
Outcome_Physical
blood pressure
80552
Outcome_Physical
Heart rate
80553
Outcome_Other
pre-ejection period
80554
Outcome_Physical
left ventricular ejection
80555
Outcome_Physical
Renal function
80556
Outcome_Physical
Blood loss
80557
Outcome_Physical
arterial pressure
80558
Participant_Condition
Prostaglandin E1 as a hypotensive drug during general anaesthesia .
80559
Participant_Condition
mastectomy