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document
The effect of resistance training during radiotherapy on spinal bone metastases in cancer patients - a randomized trial . PURPOSE To compare the effects of resistance training versus passive physical therapy on bone density in the metastatic bone during radiation therapy ( RT ) as combined treatment in patients with spinal bone metastases . Secondly , to quantify pathological fractures after combined treatment . MATERIAL AND METHODS In this randomized trial , 60 patients were allocated from September 2011 until March 2013 into one of the two groups : resistance training ( group A ) or passive physical therapy ( group B ) with thirty patients in each group during RT . Bone density in metastatic and non-metastatic vertebral bone was assessed at baseline , 3 and 6 months after RT . RESULTS Bone density in all metastases increased significantly by 28.3 % ( IQR 11.4-139.0 ) and 80.3 % ( IQR 32.6-250.6 ) after 3 and 6 months in group A ( both p < 0.01 ) . The bone density in group A was significantly increased compared to control group after 3 and 6months ( both p < 0.01 , median 59.7 ; IQR 21.1-98.3 and median 62.9 ; IQR -9.7 to 161.7 ) . The bone density data in group B showed no significant increase over the course of time ( p = 0.289 , median 5.5 , IQR 0.0-62.2 and p = 0.057 , median 52.1 , IQR 0.0-162.7 ) . 23.3 % of the patients in group A and 30.0 % of the patients in group B had pathological fractures , no fracture was assigned to intervention , and no difference between groups after 3 and 6 months was observed ( p = 0.592 and p = 0.604 ) . CONCLUSIONS Our trial demonstrated that resistance training concomitant to RT can improve bone density in spinal bone metastases . This combined treatment is effective , practicable , and without side effects for patients . Importantly , the pathological fracture rate in the intervention group was not increased . The results offer a rationale for future large controlled investigations to confirm these findings . TRIAL REGISTRATION Clinical trial identifier NCT01409720 .
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Intervention_Physical
resistance training
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Intervention_Educational
during
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Intervention_Physical
radiotherapy
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Intervention_Physical
resistance training
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Intervention_Physical
passive physical therapy
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Intervention_Pharmacological
radiation therapy ( RT )
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Intervention_Physical
resistance training
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Intervention_Physical
passive physical therapy
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Intervention_Control
control
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Intervention_Physical
resistance training
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Intervention_Educational
concomitant to RT
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Outcome_Physical
spinal bone metastases
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Outcome_Physical
bone density in the metastatic bone
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Outcome_Physical
Bone density in metastatic and non-metastatic vertebral bone
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Outcome_Physical
Bone density in all metastases
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Outcome_Physical
bone density
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Outcome_Physical
bone density data
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Outcome_Physical
pathological fractures
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Outcome_Physical
bone density
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Outcome_Adverse-effects
side effects
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Outcome_Physical
pathological fracture rate
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Participant_Condition
spinal bone metastases in cancer patients
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Participant_Condition
patients with spinal bone metastases
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Participant_Sample-size
60 patients