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document
Is a calculated total hip BMD of clinical use ? The diagnosis of osteoporosis is based on bone mass measurement . To avoid the errors associated with the measurement of spinal bone density the total hip has been accepted as the standard measurement site . This information is not available for many early measurements . We have assessed whether it is possible to derive clinically useful information about total hip bone mineral density ( BMD ) from measurements at other hip sites . The bone mass measurements of 46 patients participating in a current trial of therapy for osteoporosis were reviewed . The total hip BMD as directly measured was compared with that obtained from the formula : Total hip BMD = 0.48 x Neck BMD + 0.62 x Trochanteric BMD + 0.03 . In 30 patients with follow-up data the rate of change in hip BMD over a year was also determined by both methods . In the pretreatment state there was good agreement between the two measures ( r2 = 0.96 , SEE 0.012 g/cm2 ) . If the formula was used to compute a change in total hip BMD , the agreement between both methods remained good . However , the standard error of the estimate of the change represented 59 % of the observed change . This indicates that the error associated with this estimate is too great to allow clinically meaningful conclusions to be drawn from calculated total hip BMD . We conclude that , whilst it may be possible to obtain reasonable point estimates of total hip BMD from other measures in the hip , these estimates are too imprecise to allow conclusions about change in BMD to be made .
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Outcome_Physical
total hip BMD
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Outcome_Physical
Total hip BMD
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Outcome_Physical
Neck BMD
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Outcome_Physical
Trochanteric BMD
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Outcome_Physical
rate of change in hip BMD
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Outcome_Other
agreement
3979
Outcome_Physical
change in total hip BMD
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Outcome_Other
agreement
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Outcome_Other
error associated with this estimate
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Outcome_Physical
calculated total hip BMD .
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Outcome_Physical
total hip BMD
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Outcome_Physical
change in BMD
3985
Participant_Sample-size
46
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Participant_Condition
osteoporosis
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Participant_Sample-size
30