24408
document
[ The comparison of the effect of enalapril and indapamide on the peripheral blood pressure and central blood pressure through pulse wave analysis ] . OBJECTIVES The purpose of this study was to evaluate the effects of the angiotensin-converting enzyme ( ACE ) inhibitor enalapril and diuretic indapamide on the peripheral blood pressure and the central blood pressure in Chinese patients with essential hypertension . METHODS This study was a double blind , randomized study . Informed consent were given by all patients . After 2 weeks of placebo run-in period , 105 patients with mild or moderate essential hypertension were randomized to receive either enalapril ( 10 mg per day ) or indapamide ( 2.5 mg per day ) for 8 weeks . Radial pulse wave recordings were performed in all the patients before the active treatments were given and at the end of the study . Only those patients who have finished 8 weeks of active treatment in both groups were included into the final analysis . RESULTS One hundred one patients ( 51 in enalapril group and 50 in indapamide group ) completed the study . No significant difference ( all P values > 0.05 ) was found in baseline data between the two groups . After 8 weeks of treatment , all the parameters of pulse wave ( except heart rates in both groups and augmentation index in indapamide group ) decreased significantly . Comparison of the 2 groups showed that there were no significant differences ( all P values > 0.05 ) in all the parameters of pulse wave except that the central systolic blood pressure , augmentation and augmentation index were significantly lower in enalapril group than in indapamide group . In enalapril group , the reduced values of systolic blood pressure and pulse pressure in central aorta were significantly larger than those in brachial artery . However , the difference was not observed in indapamide group . CONCLUSIONS Enalapril and indapamide are both similarly effective in reducing peripheral arterial blood pressure . Moreover , enalapril is more effective in reducing central systolic pressure and augmentation index than indapamide . The difference is probably due to the reduction of wave reflection caused by enalapril .
24409
Intervention_Pharmacological
enalapril
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Intervention_Pharmacological
indapamide
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Intervention_Pharmacological
angiotensin-converting enzyme ( ACE ) inhibitor enalapril
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Intervention_Pharmacological
diuretic indapamide
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Intervention_Control
placebo
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Intervention_Pharmacological
enalapril
24415
Intervention_Pharmacological
indapamide
24416
Intervention_Pharmacological
enalapril
24417
Intervention_Pharmacological
indapamide
24418
Intervention_Pharmacological
indapamide
24419
Intervention_Pharmacological
enalapril
24420
Intervention_Pharmacological
indapamide
24421
Intervention_Pharmacological
enalapril
24422
Intervention_Pharmacological
indapamide
24423
Intervention_Pharmacological
Enalapril
24424
Intervention_Pharmacological
indapamide
24425
Intervention_Pharmacological
enalapril
24426
Intervention_Pharmacological
indapamide
24427
Intervention_Pharmacological
enalapril
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Outcome_Physical
peripheral blood pressure and central blood pressure
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Outcome_Other
effects
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Outcome_Physical
peripheral blood pressure and the central blood pressure
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Outcome_Physical
parameters of pulse wave
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Outcome_Physical
central systolic blood pressure
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Outcome_Physical
augmentation and augmentation index
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Outcome_Physical
systolic blood pressure and pulse pressure in central aorta
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Outcome_Physical
difference
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Outcome_Physical
central systolic pressure and augmentation index
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Outcome_Physical
wave reflection
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Participant_Condition
Chinese patients with essential hypertension .
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Participant_Condition
105 patients with mild or moderate essential hypertension