85628
document
[ The effect of indobufen on aortocoronary bypass patency after 1 week and after 1 year ] . A randomized clinical study was conducted to compare the effect of " conventional " antiaggregation therapy ( ASA plus dipyridamole ) versus indobufen in patients after aortocoronary bypass ( ACB ) surgery . The patency of venous ACB using coronary DSA one week and one year after surgery was evaluated in 52 patients divided into two groups . The study included only ACB 's with intraoperative blood flow rates < or = 40 ml/min as it is just these ACB 's which are at the highest risk of early and late occlusions . While , in the ASA plus dipyridamole-treated group , occlusions were found in 11 of the 39 reconstructions ( 28.2 % ) , the proportion was nine out of 37 procedures ( 24.3 % ) in the indobufen group . One year after surgery , occlusion was found in 14 out of 32 ACB 's ( 43.7 % ) in the ASA plus dipyridamole group compared to 14 occlusions in 31 ACB 's ( 45.2 % ) in the indobufen group . The difference in the number of occlusions between the two groups was not statistically significant . Because of some benefits of indobufen compared to ASA ( shorter time of effect , superior tolerance in patients with ulceration ) , the former drug can be recommended for use in some indicated cases .
85629
Intervention_Pharmacological
indobufen
85630
Intervention_Pharmacological
conventional " antiaggregation therapy
85631
Intervention_Pharmacological
ASA plus dipyridamole
85632
Intervention_Pharmacological
indobufen
85633
Intervention_Pharmacological
ASA plus dipyridamole-treated
85634
Intervention_Pharmacological
indobufen
85635
Intervention_Pharmacological
dipyridamole
85636
Intervention_Pharmacological
indobufen
85637
Outcome_Physical
occlusions
85638
Outcome_Physical
occlusion
85639
Outcome_Physical
number of occlusions
85640
Outcome_Other
( shorter time of effect , superior tolerance in patients with ulceration )
85641
Participant_Condition
aortocoronary bypass patency
85642
Participant_Condition
patients after aortocoronary bypass ( ACB ) surgery .
85643
Participant_Sample-size
52