2968
document
Efficacy of a barrier cream and its vehicle as protective measures against occupational irritant contact dermatitis . The actual advantage of barrier creams over bland emollients for skin protection is still hotly debated . In a randomized , double-blinded study , a newly-introduced barrier cream and its moisturizing vehicle were compared regarding their skin compatibility , efficacy and resulting acceptance . Thus , 2 panels of 25 hospital nurses with mild signs of skin irritation were asked to use 1 of the test products provided ( verum or vehicle ) over a period of 4 weeks . Effects of both types of preparations were studied weekly by clinical examination and the instrumental assessment of bioengineering parameters . Results showed no significant differences between barrier cream and vehicle . In both groups , clinical skin status improved and stratum corneum hydration increased significantly during the study period . Both preparations were tolerated and accepted well , thus showing both skin protection and skin care . These results contribute to the debate as to whether a strict distinction between " skin care " and " skin protection " products is justified . The vehicle alone is capable of positively influencing skin status . Emphasis must be laid on regular , frequent , and correct application of a product for it to be effective .
2969
Intervention_Physical
barrier cream
2970
Intervention_Physical
its vehicle
2971
Intervention_Pharmacological
barrier creams
2972
Intervention_Pharmacological
barrier cream
2973
Intervention_Physical
verum or vehicle ) over a period of 4 weeks
2974
Intervention_Pharmacological
barrier cream
2975
Intervention_Physical
vehicle
2976
Intervention_Pharmacological
vehicle
2977
Outcome_Other
Efficacy
2978
Outcome_Physical
occupational irritant contact dermatitis
2979
Outcome_Physical
skin compatibility , efficacy and resulting acceptance
2980
Outcome_Physical
clinical skin status
2981
Outcome_Physical
stratum corneum hydration
2982
Outcome_Other
tolerated
2983
Outcome_Physical
and accepted well
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Outcome_Physical
skin protection and skin care .
2985
Participant_Condition
occupational irritant contact dermatitis
2986
Participant_Sample-size
2 panels
2987
Participant_Sample-size
25 hospital
2988
Participant_Condition
skin irritation