87293
document
Intra-articular hyaluronic acid compared to intra-articular triamcinolone hexacetonide in inflammatory knee osteoarthritis . The aim of this study was to determine the comparative efficacy and safety of intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA ) in inflammatory knee osteoarthritis . A randomized double-blind comparative trail was carried out in a rheumatology outpatient department . There were 63 patients ( 24 male , 39 female , mean age 70.5 years ) with bilateral symptomatic knee osteoarthritis with effusion . Each was given five HA injections at weekly intervals ; or 20 mg TH followed by four placebo ( saline ) injections . Patients were examined weekly during the treatment period and then at monthly intervals for a further 6 months . Assessment included recording of : visual analog scores ( VAS ) for pain ; duration of stiffness ; range of movement ; joint effusion ; local heat ; synovial thickening ; joint-line and periarticular tenderness . The principal outcome measure was pain on a self-selected activity assessed by Vas . The two groups were comparable at entry and no significant differences between the groups developed at any time during the treatment period . However , there was a high drop-out rate and intention to treat analysis failed to demonstrate statistically significant differences between the groups . In patients remaining in the study , significantly less pain was experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of experienced by the HA group during the 6 month follow-up period . Other parameters showed a similar trend in favor of HA . We could not , however , demonstrate significant differences between the placebo and active treatments . HA may therefore be a useful additional therapy for symptomatic knee osteoarthritis and may have a long duration of action .
87294
Intervention_Pharmacological
hyaluronic acid
87295
Intervention_Pharmacological
triamcinolone hexacetonide
87296
Intervention_Pharmacological
intra-articular ( i/a ) triamcinolone . hexacetonide ( TH ) and i/a hyaluronic acid ( HA )
87297
Intervention_Pharmacological
HA injections
87298
Intervention_Control
20 mg
87299
Intervention_Pharmacological
TH
87300
Intervention_Control
placebo ( saline ) injections
87301
Intervention_Pharmacological
HA
87302
Intervention_Pharmacological
HA
87303
Intervention_Pharmacological
HA
87304
Intervention_Pharmacological
HA
87305
Outcome_Pain
visual analog scores ( VAS ) for pain
87306
Outcome_Physical
duration of stiffness
87307
Outcome_Physical
range of movement
87308
Outcome_Physical
joint effusion
87309
Outcome_Physical
local heat
87310
Outcome_Physical
synovial thickening
87311
Outcome_Physical
joint-line and periarticular tenderness
87312
Outcome_Pain
pain on a self-selected activity assessed by Vas
87313
Outcome_Pain
pain
87314
Participant_Condition
inflammatory knee osteoarthritis
87315
Participant_Condition
inflammatory knee osteoarthritis
87316
Participant_Sample-size
63 patients
87317
Participant_Sex
24 male
87318
Participant_Sex
39 female
87319
Participant_Age
age 70.5 years
87320
Participant_Condition
bilateral symptomatic knee osteoarthritis with effusion
87321
Participant_Condition
symptomatic knee osteoarthritis