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document
[ Myocardial ischemia with stable angina pectoris : clinico-ergometric evaluation after the use of diltiazem ] . PURPOSE To evaluate the efficacy of diltiazem versus placebo in patients with stable angina . METHODS Eight-seven angina pectoris patients , mean age of 57 +/- 9 , 82 white and 79 male were evaluated in a randomized , double-blind trial of two groups of patients diltiazem and placebo , 3 to 4 tablets a day ( diltiazem 180 to 240 mg daily ) . The patients were evaluated after laboratory tests and clinical-ergometric examinations . A coronary arteriography was performed on study entry . RESULTS The average of anginal attacks , number of weekly sublingual nitrate , heart rate , systolic and diastolic pressure at rest and at the end of diltiazem period were significantly lower ( p < 0.05 ) regarding same periods on placebo . The percentage of depression for ST-segment was lower for diltiazem when compared with placebo ( p < 0.05 ) and the percentage of patients that reach higher stages in the ergometric test was significantly better for diltiazem . Heart rate and systolic plus diastolic pressures after exercise did not differ in both groups . CONCLUSION Diltiazem reduced the clinical and electrocardiographical aspects and raises the effort tolerance during the ergometric test in patients with stable angina .
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Intervention_Pharmacological
diltiazem ]
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Intervention_Pharmacological
diltiazem
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Intervention_Control
placebo
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Intervention_Pharmacological
diltiazem
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Intervention_Control
placebo
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Intervention_Pharmacological
diltiazem
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Intervention_Control
placebo
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Intervention_Pharmacological
diltiazem
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Intervention_Control
placebo
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Intervention_Pharmacological
diltiazem
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Intervention_Pharmacological
Diltiazem
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Outcome_Physical
average of anginal attacks
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Outcome_Other
number of weekly sublingual nitrate
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Outcome_Physical
heart rate
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Outcome_Physical
systolic and diastolic pressure at rest and at the end of diltiazem period
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Outcome_Physical
depression for ST-segment
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Outcome_Physical
Heart rate
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Outcome_Physical
systolic plus diastolic pressures
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Participant_Condition
stable angina
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Participant_Sample-size
Eight-seven
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Participant_Condition
angina pectoris
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Participant_Age
mean age of 57 +/- 9
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Participant_Condition
82 white
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Participant_Sex
79 male