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document
Intra-articular hyaluronic acid compared to exercise therapy in osteoarthritis of the ankle . A prospective randomized trial with long-term follow-up . OBJECTIVE The goal of this study has been to determine whether hyaluronic acid ( HA ) or exercise therapy can improve functional parameters in patients with osteoarthritis ( OA ) of the ankle . METHODS In a prospective clinical trial , 43 ankles ( 30 patients ) with radiographic Kellgren Lawrence grade III OA were randomized to receive three intra-articular HA injections , with one-week interval of or exercise therapy for six weeks . Patients were evaluated by the American Orthopaedic Foot and Ankle Society ( AOFAS ) Ankle-Hindfoot Scale and followed-up after 12 months . RESULTS Total AOFAS Ankle-Hindfoot score of OA patients has improved in both groups , varying from 61.6+/-16.8 to 90.1+/-9.7 with HA treatment and from 72.1+/-16.6 to 87.5+/-17.5 using exercise therapy at the end of the trial ( p < 0.01 ) . There were no statistically significant differences between the groups . CONCLUSION This prospective randomized trial confirmed that , both HA injections and exercise therapy provide functional improvement . However , larger trials with longer follow-up are necessary for more definite conclusions .
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Intervention_Pharmacological
hyaluronic acid
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Intervention_Physical
exercise therapy
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Intervention_Pharmacological
hyaluronic acid ( HA )
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Intervention_Physical
exercise therapy
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Intervention_Pharmacological
three intra-articular HA injections
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Intervention_Physical
exercise therapy
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Intervention_Pharmacological
HA
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Intervention_Physical
exercise therapy
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Intervention_Pharmacological
HA
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Intervention_Physical
exercise therapy
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Outcome_Physical
American Orthopaedic Foot and Ankle Society ( AOFAS ) Ankle-Hindfoot Scale
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Outcome_Physical
Total AOFAS Ankle-Hindfoot score of OA patients
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Participant_Condition
osteoarthritis of the ankle
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Participant_Condition
osteoarthritis
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Participant_Condition
OA
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Participant_Sample-size
30
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Participant_Condition
radiographic Kellgren Lawrence grade III OA