76797
document
Intravenous regional anaesthesia below the knee . A cross-over study with prilocaine in volunteers . The quality of anaesthesia provided by three dosages of prilocaine , 40 ml 0.5 % , 20 ml 1 % , or 40 ml 1 % , administered in random order , for intravenous regional anaesthesia of the lower extremity below the knee was compared in six volunteers . Limited sensory blockade was achieved in the groups with 40 ml 0.5 % and 20 ml 1 % during the 30-minute test period . One subject was not fully anaesthetised with any of the dosages used . Recovery was rapid ( mean 12-13 minutes ) in these two groups . In two subjects given 40 ml of 1 % , complete recovery took 90 minutes . At 30 minutes , the degree of flexion remaining in the great toe ( control 100 % ) was 4 % in the groups who received 40 ml of 0.5 % and 1 % , but 34 % in those who received 20 ml of 1 % respectively . Full motor recovery was achieved in 8-9 minutes . Five of six volunteers who received the 400-mg dose experienced subjective signs of central nervous system side effects when the cuff was released . In this group , the mean plasma level of prilocaine at 2 minutes was 1.22 micrograms/ml , maximum 2.12 micrograms/ml . In a radiological examination , no leak of contrast medium under the tourniquet cuff ( 300 mmHg ) was detected . The development of anaesthesia was fastest following the largest dose , but the large number of central side effects makes that dosage less suitable for clinical work .
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Intervention_Pharmacological
Intravenous regional anaesthesia
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Intervention_Pharmacological
prilocaine
76800
Intervention_Pharmacological
prilocaine
76801
Intervention_Pharmacological
prilocaine
76802
Outcome_Physical
Recovery was rapid
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Outcome_Physical
complete recovery
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Outcome_Physical
degree of flexion remaining in the great toe
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Outcome_Physical
Full motor recovery
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Outcome_Adverse-effects
subjective signs of central nervous system side effects
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Outcome_Physical
mean plasma level
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Outcome_Physical
no leak of contrast medium under the tourniquet cuff ( 300 mmHg )
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Outcome_Other
fastest
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Outcome_Adverse-effects
large number of central side effects
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Outcome_Physical
less suitable for clinical work
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Participant_Sample-size
six