86026
document
Treatment of vasculogenic sexual dysfunction with pentoxifylline . OBJECTIVE To evaluate the use of pentoxifylline to treat impotence in men with mild to moderate penile vascular insufficiency . DESIGN Double-blind randomized clinical trial . SETTING Sexual Dysfunction Clinic at VA Medical Center , Sepulveda , CA . PARTICIPANTS Convenience sample of couples . INTERVENTION Twelve weeks of treatment with placebo or 400 mg tid of pentoxifylline . MEASUREMENTS ( 1 ) Report of patient verified by partner as to number of coital episodes per month ; ( 2 ) penile-brachial pressure index determinations . RESULTS Pentoxifylline therapy regularly increased the PBPI in impotent men in comparison with the placebo , frequently into the normal range . Pentoxifylline therapy was particularly useful in restoring the PBPI in men with the pelvic steal syndrome ; six of seven such subjects improved into the normal range . During the pentoxifylline treatment period , in contrast with the control period , nine men were able to reestablish coital function and three had no improvement . Six couples did not attempt intercourse despite a professed interest in sexual activity ; however five out of the six men experienced erections during episodes of fantasy or attempts at masturbation during treatment . There were no complications of therapy . CONCLUSIONS These promising preliminary results suggest a well tolerated alternative therapy for erectile dysfunction in patients with mild to moderate penile vascular disease .
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Intervention_Pharmacological
pentoxifylline .
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Intervention_Pharmacological
pentoxifylline
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Intervention_Control
placebo
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Intervention_Pharmacological
400 mg tid of pentoxifylline
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Intervention_Pharmacological
Pentoxifylline therapy
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Outcome_Mental
Report of patient verified by partner as to number of coital episodes per month
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Outcome_Physical
penile-brachial pressure index determinations
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Outcome_Mental
PBPI
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Outcome_Mental
restoring the PBPI
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Outcome_Mental
reestablish coital function
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Outcome_Mental
attempt intercourse
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Outcome_Mental
sexual activity
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Outcome_Mental
erections during episodes of fantasy or attempts at masturbation
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Outcome_Adverse-effects
complications
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Participant_Condition
vasculogenic sexual dysfunction