83747
document
Paromomycin for cryptosporidiosis in AIDS : a prospective , double-blind trial . To test the effects of paromomycin , 10 patients with AIDS and cryptosporidiosis were randomized to paromomycin or placebo in a double-blind trial . After 14 days , patients were switched to the other treatment for 14 additional days . Measures included the number and character of each stool and weekly 24-h stool specimens for weight and oocyst excretion . During the paromomycin treatment phase , oocyst excretion decreased from 314 x 10 ( 6 ) to 109 x 10 ( 6 ) 24 h ( P < .02 ) . Oocyst excretion increased for the 4 patients initially on placebo compared to a median decrease of 128 x 10 ( 6 ) /24 h for the 6 initially treated with drug ( P < .02 ) . Stool frequency also decreased more in those treated with drug ( 3.6 fewer vs. 1.25 fewer/24 h , P < .05 ) . Trends favored drug over placebo for stool weight , stool character , and Karnofsky score . Paromomycin treatment resulted in improvement in both clinical and parasitologic parameters in cryptosporidiosis in AIDS .
83748
Intervention_Pharmacological
Paromomycin
83749
Intervention_Pharmacological
paromomycin
83750
Intervention_Pharmacological
paromomycin
83751
Intervention_Control
placebo
83752
Intervention_Pharmacological
paromomycin
83753
Intervention_Control
placebo
83754
Intervention_Pharmacological
drug
83755
Intervention_Control
placebo
83756
Intervention_Pharmacological
Paromomycin
83757
Outcome_Physical
number and character of each stool
83758
Outcome_Physical
stool specimens for weight
83759
Outcome_Physical
oocyst excretion
83760
Outcome_Physical
oocyst excretion
83761
Outcome_Physical
Oocyst excretion
83762
Outcome_Other
Stool frequency
83763
Outcome_Physical
stool weight , stool character
83764
Outcome_Other
Karnofsky score
83765
Participant_Condition
AIDS :