86841
document
Effect of marine oils supplementation on coagulation and cellular activation in whole blood . A study was performed to explore the effects of supplemental intake of various marine oils known to be part of the Eskimo diet . Healthy men and women ( 134 ) were randomly selected to consume 15 mL/d of oil from blubber of seal , cod liver , seal/cod liver , blubber of Minke whale , or no oil for ten weeks . Total cholesterol was unchanged in the oil groups , whereas high density lipoprotein cholesterol increased 7 % in the seal/cod liver oil ( CLO ) group ( P < 0.05 ) and 11 % in the whale oil group ( P < 0.005 ) . Triacylglycerol was significantly reduced in the CLO group only . The concentration of prothrombin fragment 1 + 2 was reduced 25 % ( P < 0.05 ) after whale oil supplementation . No change in fibrinogen or factor VIIc was detected . Tumor necrosis factor generation in lipopolysaccharide ( LPS ) -stimulated blood was 30 % reduced after whale oil ( P < 0.05 ) , but was unaffected by intake of seal or CLO . The LPS-induced tissue factor activity in monocytes was reduced to a significant degree only in the seal/CLO group ( 34 % ) and whale oil group ( 35 % ) ( P < 0.05 ) . The most dramatic change in thromboxane B2 in LPS-stimulated blood was seen after whale oil intake with 44 % reduction ( P < 0.01 ) . Supplementation of a regular diet with a combination of seal oil and CLO and especially with whale oil seems to have beneficial effects on several products thought to be associated with cardiovascular and thrombotic diseases .
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Intervention_Pharmacological
marine oils supplementation
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Intervention_Pharmacological
oil from blubber of seal , cod liver , seal/cod liver
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Intervention_Physical
,
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Intervention_Pharmacological
blubber of Minke whale
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Intervention_Control
no oil
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Intervention_Pharmacological
seal/cod liver oil
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Intervention_Pharmacological
whale oil
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Outcome_Physical
Total cholesterol
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Outcome_Physical
high density lipoprotein cholesterol
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Outcome_Physical
Triacylglycerol
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Outcome_Physical
concentration of prothrombin fragment 1 + 2
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Outcome_Physical
fibrinogen or factor VIIc
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Outcome_Physical
Tumor necrosis factor generation in lipopolysaccharide ( LPS ) -stimulated blood
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Outcome_Physical
LPS-induced tissue factor activity in monocytes
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Outcome_Physical
thromboxane B2
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Participant_Condition
Eskimo diet
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Participant_Sex
men and women