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document
Adequacy of vitamin B6 supplementation during pregnancy : a prospective study . This prospective study assesses the effect of 2.5 , 4 , and 10 mg of pyridoxine supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal 5'-phosphate ( PLP ) and on the degree of coenzyme saturation ( activation factor ) of aspartate aminotransferase and alanine aminotransferase ( alphaEGOT and alphaEGPT ) in maternal erythrocytes . More than 4 mg of pyridoxine supplementation daily was required for most pregnancies to maintain maternal plasma PLP levels within the range observed during the first trimester and in the nonpregnant state . The plasma PLP concentrations in maternal and cord blood were highly correlated and indicated a dependence of fetal vitamin B6 nutrition on maternal circulating PLP . Measurements of alphaEGOT and alphaEGPT were not as reproducible as plasma PLP assays and were less sensitive and quantitative indicators . In the majority of subjects , the changes in alphaEGOT and alphaEGPT with time correlated poorly with the changes in plasma PLP . However , when the data were analyzed without regard for their dependence on time , they demonstrated a negative , linear correlation between alphaEGOT and log plasma PLP and between alphaEGPT and log plasma PLP for the group on 2.5 mg of pyridoxine and for all the subjects combined . Finally , the dietary records showed that most of the subjects consumed less than 2 mg of vitamin B6 daily from their food . The results indicate that the current Recommended Dietary Allowance for vitamin B6 during pregnancy ( 2.5 mg ) is too low and that supplementation of this vitamin in an amount more than 4 mg daily is recommended .
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Intervention_Pharmacological
vitamin B6 supplementation
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Intervention_Pharmacological
pyridoxine supplementation
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Intervention_Pharmacological
4 mg of pyridoxine supplementation daily
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Intervention_Pharmacological
pyridoxine
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Intervention_Pharmacological
vitamin B6
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Intervention_Pharmacological
vitamin B6
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Outcome_Physical
maternal and fetal plasma levels of pyridoxal 5'-phosphate ( PLP )
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Outcome_Physical
degree of coenzyme saturation ( activation factor ) of aspartate aminotransferase
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Outcome_Physical
alanine aminotransferase ( alphaEGOT and alphaEGPT ) in maternal erythrocytes
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Outcome_Physical
maternal plasma PLP levels
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Outcome_Physical
plasma PLP concentrations in maternal and cord blood
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Outcome_Physical
Measurements of alphaEGOT and alphaEGPT
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Outcome_Physical
plasma PLP assays
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Outcome_Physical
changes in alphaEGOT and alphaEGPT
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Outcome_Physical
plasma PLP
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Outcome_Physical
alphaEGOT
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Outcome_Physical
plasma PLP
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Outcome_Physical
alphaEGPT
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Outcome_Physical
log plasma PLP
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Participant_Condition
pregnancy
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Participant_Condition
pregnancy