79078
document
Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788 . The benzodiazepines are typified by a profile of side effects which includes drowsiness , ataxia and incoordination . Ro 15-1788 , an imidazodiazepine derivative , exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man . It is devoid of any behavioural activity in animals , except at very high doses . In the present study the effects of single rising oral doses of Ro 15-1788 on cognitive , psychomotor and subjective function in man have been assessed using a battery of psychometric tests designed to identify the sedative action of the benzodiazepines . At all doses up to 600 mg , Ro 15-1788 demonstrated none of the classical behavioural effects of the benzodiazepines .
79079
Intervention_Pharmacological
benzodiazepine
79080
Intervention_Pharmacological
Ro 15-1788
79081
Intervention_Pharmacological
Ro 15-1788
79082
Intervention_Pharmacological
Ro 15-1788
79083
Outcome_Physical
central effects
79084
Outcome_Physical
drowsiness
79085
Outcome_Physical
ataxia
79086
Outcome_Physical
incoordination
79087
Outcome_Mental
cognitive
79088
Outcome_Mental
psychomotor
79089
Outcome_Mental
subjective function
79090
Outcome_Mental
psychometric tests
79091
Outcome_Mental
sedative action
79092
Outcome_Mental
behavioural effects
79093
Participant_Condition
in man