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document
Quality of life and fatigue of patients with spinal bone metastases under combined treatment with resistance training and radiation therapy- a randomized pilot trial . BACKGROUND The aim of this trial was to compare the effects of resistance training versus passive physical therapy on quality of life ( QoL ) , fatigue , and emotional distress outcomes during radiation therapy in patients with spinal bone metastases under radiotherapy ( RT ) . METHODS In this randomized trial , 60 patients were treated from September 2011 until March 2013 into one of the two groups : isometric resistance training or physical therapy with thirty patients in each group during RT . EORTC QLQ-BM22 , EORTC QLQ-FA13 , and FBK-R10 were assessed at baseline , three months , and six months after RT . RESULTS Psychosocial aspects in resistance training group ( Arm A ) were significantly improved after three ( p = 0.001 ) and six months ( p = 0.010 ) . Other rated items of the QLQ-BM22 painful site , and pain characteristics were without significant differences . Functional interference showed a positive trend after six months ( p = 0.081 ) . After six months , physical fatigue ( p = 0.013 ) , and interference with daily life ( p = 0.006 ) according to the QLQ-FA13 assessment improved in Arm A significantly . Emotional distress was in Arm A lower after six months ( p = 0.016 ) . The Cohen 's effect size confirmed the clinically significant improvement of these findings . CONCLUSIONS In this group of patients we were able to show that guided isometric resistance training of the paravertebral muscles can improve functional capacity , reduce fatigue and thereby enhance QoL over a 6-months period in patients with stable spinal metastases . The results offer a rationale for future large controlled investigations to confirm these findings . TRIAL REGISTRATION Clinical trial identifier NCT01409720 .
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Intervention_Physical
resistance training
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Intervention_Physical
radiation therapy-
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Intervention_Physical
resistance training versus passive physical therapy
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Intervention_Physical
radiotherapy ( RT ) .
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Intervention_Physical
isometric resistance training
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Intervention_Physical
physical therapy
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Intervention_Physical
RT
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Intervention_Physical
RT
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Intervention_Physical
resistance training
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Outcome_Other
Quality of life and
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Outcome_Physical
fatigue
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Outcome_Other
quality of life ( QoL ) ,
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Outcome_Mental
fatigue , and emotional distress
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Outcome_Mental
EORTC QLQ-BM22 , EORTC QLQ-FA13
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Outcome_Mental
FBK-R10
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Outcome_Physical
physical
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Outcome_Physical
interference
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Outcome_Physical
functional capacity
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Outcome_Physical
fatigue
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Participant_Condition
spinal bone metastases
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Participant_Condition
radiation therapy-
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Participant_Condition
patients with spinal bone metastases under radiotherapy ( RT )
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Participant_Sample-size
60