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document
Effect of ginseng extract supplementation on testicular functions in diabetic rats . OBJECTIVE It was aimed to investigate the effect of standardized ginseng extract on fertility parameters in diabetic rats . METHODS Thirty male rats were randomly allocated into three groups of 10 rats each : 1. controls , 2. diabetes ( D ) and 3. diabetes + ginseng ( DG ) . The latter two groups were rendered diabetic by i.p . injection of streptozotocin ( STZ ; 50 mg/kg ) . Standardized ginseng extract ( Dansk Droge A/S , Copenhagen , Denmark ) was administered per os ( 100 mg/kg BW ) by stomach tube daily for 90 days starting one week after STZ . Ninety days post STZ the rats were sacrificed , and testis , epididymis , prostate , and seminal vesicles were weighed and subjected to histological examination . In addition , spermiogram , testicular enzyme markers , intratesticular steroid hormonal profile and testicular antioxidant status were estimated . RESULTS The administration of ginseng extract resulted in a significant improvement of fertility parameters and testicular antioxidants together with a decrease in malondialdehyde and testicular pathological signs including degenerative changes of the seminiferous tubules . CONCLUSION Ginseng extract may be a beneficial adjuvant therapy for diabetics suffering from infertility as a complication .
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Intervention_Pharmacological
ginseng extract supplementation
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Intervention_Pharmacological
ginseng extract
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Intervention_Pharmacological
streptozotocin
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Intervention_Pharmacological
Standardized ginseng extract
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Intervention_Pharmacological
ginseng extract
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Intervention_Pharmacological
Ginseng extract
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Outcome_Physical
testicular functions
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Outcome_Physical
fertility parameters
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Outcome_Physical
testis , epididymis , prostate , and seminal vesicles were weighed and subjected to histological examination .
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Outcome_Physical
spermiogram , testicular enzyme markers , intratesticular steroid hormonal profile and testicular antioxidant status
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Outcome_Physical
fertility parameters and testicular antioxidants together
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Outcome_Physical
decrease in malondialdehyde and testicular pathological signs including degenerative changes of the seminiferous tubules .
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Outcome_Physical
infertility
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Participant_Condition
diabetic
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Participant_Condition
diabetic rats
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Participant_Sample-size
Thirty
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Participant_Sex
male