8955
document
Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice . AIMS To determine whether metformin pretreatment has beneficial effects in clomiphene resistant infertile women with polycystic ovary syndrome ( PCOS ) in an infertility clinic . METHODS This was a randomized placebo controlled double-blind crossover study of 3 months metformin ( 1500 mg day-1 ) /placebo , followed by 3 months metformin/placebo together with clomiphene ( 50-100 mg for 5 days ) for three cycles in clomiphene resistant women with PCOS . The primary outcomes were restoration of spontaneous menses , ovulation induction ( spontaneous or clomiphene induced ) and pregnancy . Secondary endpoints were changes in biochemical parameters related to androgens and insulin . RESULTS Twelve women completed the metformin arm and 14 the placebo arm . Spontaneous menstruation resumed in five metformin treated patients and in six placebo treated women , P=0.63 . No women given metformin spontaneously ovulated , although one patient given placebo did , P=0.30 . There was no difference in the efficacy of clomiphene between the two groups with ovulation being induced in five ( out of 12 ) metformin treated women and four ( out of 14 ) placebo treated women , P=0.63 . Pregnancy occurred in three ( out of 12 ) women given metformin and two ( out of 14 ) women given placebo , P=0.59 . CONCLUSIONS Metformin is not always beneficial when given to clomiphene resistant infertile women with PCOS in clinical practice .
8956
Intervention_Pharmacological
Metformin
8957
Intervention_Pharmacological
metformin
8958
Intervention_Pharmacological
metformin
8959
Intervention_Control
/placebo
8960
Intervention_Pharmacological
metformin/placebo
8961
Intervention_Pharmacological
metformin
8962
Intervention_Control
placebo
8963
Intervention_Pharmacological
metformin
8964
Intervention_Control
placebo
8965
Intervention_Control
placebo
8966
Intervention_Pharmacological
metformin
8967
Intervention_Control
placebo
8968
Intervention_Pharmacological
metformin
8969
Intervention_Control
placebo
8970
Intervention_Pharmacological
Metformin
8971
Outcome_Physical
beneficial effects
8972
Outcome_Physical
restoration of spontaneous menses , ovulation induction ( spontaneous or clomiphene induced ) and pregnancy . Secondary endpoints
8973
Outcome_Physical
Spontaneous menstruation
8974
Outcome_Physical
spontaneously ovulated
8975
Outcome_Physical
efficacy of clomiphene
8976
Outcome_Physical
ovulation being induced
8977
Outcome_Physical
Pregnancy
8978
Participant_Condition
clomiphene resistant polycystic ovary syndrome
8979
Participant_Condition
clomiphene resistant infertile
8980
Participant_Sex
women
8981
Participant_Condition
polycystic ovary syndrome
8982
Participant_Condition
PCOS
8983
Participant_Condition
clomiphene resistant
8984
Participant_Sex
women
8985
Participant_Condition
PCOS
8986
Participant_Sample-size
Twelve
8987
Participant_Sex
women
8988
Participant_Sample-size
14
8989
Participant_Condition
clomiphene resistant infertile
8990
Participant_Sex
women
8991
Participant_Condition
PCOS