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document
Qingre quyu granule stabilizes plaques through inhibiting the expression of tenascin-C in patients with severe carotid stenosis . OBJECTIVE To investigate the therapeutic effects of Qingre Quyu Granule ( QQG ) on the patients with severe carotid stenosis , and to explore the mechanism of it . METHODS Ninety-six patients with severe carotid stenosis were enrolled in the study and were classified into a QQG group ( n=48 ) and a control group ( n=48 ) randomly using consecutively numbered envelopes . The patients in the QQG group were given QQG and Western medicine , those in the control group were given Western medicine merely , the course of treatment was 16 weeks . All patients went through endarterectomy after treatment . Plaques were subjected to the analysis of CD3 , CD68 , soluble intercellular adhesion molecule 1 ( ICAM-1 ) , matrix metalloprotease-9 ( MMP-9 ) , CD40L , tenascin-C , and collagen content lipid content by immunohistochemistry or polarized light analysis . RESULTS By the end of experiment , the expressions of CD3 , CD68 , ICAM-1 , MMP9 , CD40L and tenascin-C on the plaques were statistically significant lower in the QQG group compared with the control group ( P < 0.01 ) . The lipid content of the plaque was also significantly lower in the QQG group compared with the control group ( P < 0.01 ) . The interstitial collagen in the tissue sections of the plaques was also significantly higher in the QQG group in comparison with the control group ( P < 0.01 ) . CONCLUSION QQG could stabilize carotid artery plaques through inhibiting pro-inflammation factors and restraining the tenascin-C and MMP9 pathway .
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Intervention_Pharmacological
Qingre Quyu Granule ( QQG )
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Intervention_Pharmacological
QQG
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Intervention_Control
control group
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Intervention_Pharmacological
QQG
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Intervention_Pharmacological
QQG
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Intervention_Other
Western medicine
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Intervention_Other
Western medicine
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Intervention_Pharmacological
QQG
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Intervention_Pharmacological
QQG
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Intervention_Pharmacological
QQG
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Outcome_Physical
therapeutic effects
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Outcome_Physical
expressions of CD3 , CD68 , ICAM-1 , MMP9 , CD40L and tenascin-C
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Outcome_Physical
lipid content of the plaque
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Participant_Condition
patients with severe carotid stenosis
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Participant_Condition
patients with severe carotid stenosis
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Participant_Sample-size
Ninety-six
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Participant_Condition
with severe carotid stenosis