41535
document
Clinical effects of nanocrystalline hydroxyapatite paste in the treatment of intrabony periodontal defects : a randomized controlled clinical study . The purpose of the present randomized controlled clinical study was to compare the clinical outcomes of papilla preservation flap surgery with or without the application of a novel nanocrystalline hydroxyapatite ( nano-HA ) bone graft substitute . Fourteen patients with paired intrabony periodontal defects of ≥ 4 mm participated in this split-mouth design study . The defects in each subject were randomly selected to receive nano-HA paste in conjunction with papilla preservation flaps or papilla preservation flaps alone . Probing bone levels ( PBL ) from a customized acrylic stent and probing pocket depths ( PPD ) were measured at baseline and again 6 months following surgery . No differences in any of the investigated parameters were observed at baseline between the two groups . Healing was uneventful in all patients . Both treatments resulted in significant improvements between baseline and 6 months ( p < 0.05 ) . At 6 months after therapy , the sites treated with nano-HA paste showed a reduction in mean PPD from 8.3 ± 1.2 to 4.0 ± 1.1 mm and a gain in PBL of 4.3 ± 1.4 mm , whereas in the control group , the mean PPD changed from 7.9 ± 1.2 mm to 5.0 ± 1.2 mm and PBL gain was 2.6 ± 1.4 mm . Results demonstrated statistically greater PPD reduction and PBL gain ( p < 0.05 ) in the test group as compared with the control group . In conclusion , after 6 months , the treatment of intrabony periodontal defects with a nano-HA paste leads to significantly improved clinical outcomes when compared with papilla preservation flap surgery alone .
41536
Intervention_Pharmacological
nanocrystalline hydroxyapatite paste
41537
Intervention_Pharmacological
nanocrystalline hydroxyapatite ( nano-HA ) bone graft substitute
41538
Outcome_Physical
Probing bone levels ( PBL )
41539
Outcome_Physical
probing pocket depths ( PPD )
41540
Outcome_Physical
Healing
41541
Outcome_Physical
in mean PPD
41542
Outcome_Physical
mean
41543
Outcome_Physical
PPD reduction
41544
Outcome_Physical
PBL