35943
document
The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia . Sequential methotrexate ( Mtx ) absorption studies were undertaken in 127 children undergoing treatment for childhood non-T acute lymphoblastic leukaemia ( ALL ) to determine whether serum drug concentration , clearance and dosage affect event free survival ( EFS ) . Higher serum concentration and area under the plasma concentration curve ( AUC ) were not associated with an improved EFS . Methotrexate clearance was not found to be of prognostic significance . Patients who tolerated only low 6-mercaptopurine ( 6-MP ) doses because of neutropaenia and those who randomly were prescribed higher doses of Mtx had a lower rate of leukaemia relapse after the completion of therapy . This suggests that the use of maintenance therapy in maximally tolerated doses may be associated with an increased survival in childhood ALL .
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Intervention_Pharmacological
serum methotrexate
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Intervention_Pharmacological
methotrexate
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Intervention_Pharmacological
Methotrexate
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Intervention_Pharmacological
6-mercaptopurine ( 6-MP )
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Outcome_Mental
event free survival
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Outcome_Other
Methotrexate clearance
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Outcome_Physical
rate of leukaemia relapse
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Outcome_Mortality
survival
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Participant_Age
childhood
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Participant_Condition
acute lymphoblastic leukaemia
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Participant_Sample-size
127
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Participant_Age
children
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Participant_Condition
non-T acute lymphoblastic leukaemia ( ALL )
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Participant_Age
childhood
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Participant_Condition
ALL