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Age-related response to two Haemophilus influenzae type b vaccines . Two types of Hib vaccines were compared for efficacy and safety in 71 normal children in three age groups : 36 to 72 months , 15 to 18 months , and 6 to 8 months . One vaccine contained the Hib-specific capsular polysaccharide , PRP ; the second vaccine contained PRP combined with pertussis vaccine , PRP-P. A third vaccine , DTP , was administered to a control group for each age . Anti-PRP antibody levels were greater after vaccination with PRP-P than after PRP in all three age groups . Immunoresponsiveness to both vaccines increased with age . A lower incidence of side effects was seen with both PRP ( 15 % ) and PRP-P ( 20 % ) than with DTP ( 56 % ) . The results suggest that PRP-P is both well tolerated clinically and has greater immunogenicity than PRP .
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Intervention_Pharmacological
Haemophilus influenzae type b vaccines .
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Intervention_Pharmacological
Hib vaccines
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Intervention_Pharmacological
Hib-specific capsular polysaccharide , PRP ;
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Intervention_Pharmacological
PRP
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Intervention_Pharmacological
pertussis vaccine , PRP-P.
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Intervention_Pharmacological
DTP
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Intervention_Control
control
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Intervention_Pharmacological
PRP
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Intervention_Pharmacological
PRP-P
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Intervention_Pharmacological
PRP-P
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Outcome_Physical
Age-related response
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Outcome_Other
efficacy and safety
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Outcome_Physical
Anti-PRP antibody levels
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Outcome_Physical
Immunoresponsiveness
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Outcome_Adverse-effects
lower incidence of side effects
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Outcome_Other
well tolerated clinically and has greater immunogenicity
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Participant_Sample-size
71
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Participant_Age
children
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Participant_Age
36 to 72 months , 15 to 18 months
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Participant_Age
6 to 8 months