17972
document
Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis . BACKGROUND KC 11458 , a motilin agonist without antibiotic properties , accelerates gastric emptying in animals and healthy humans . AIM To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis . METHODS Twenty-nine patients ( 6 type 1 and 23 type 2 ) with gastroparesis underwent assessments of : ( i ) gastric emptying of a solid/liquid meal using scintigraphy , ( ii ) glycaemic control ( blood glucose at 0 , 30 , 60 , 90 and 120 min during the gastric emptying measurement ) and ( iii ) upper gastrointestinal and 'meal-related ' symptoms ( questionnaire ) , at baseline and after treatment with KC 11458 in a dose of 8 mg t.d.s. , or placebo for 8 days . RESULTS KC 11458 had no statistically significant or clinically relevant effect on gastric emptying of either the solid intragastric retention at 100 min ( T100 ) ( P = 0.87 ) or liquid 50 % emptying time ( T50 ) ( P = 0.17 ) components of the meal . KC 11458 slightly worsened ( P = 0.04 ) upper gastrointestinal symptoms when compared with placebo . The magnitude of the change in solid gastric emptying correlated with the change in the blood glucose concentration ( r = 0.49 ; P < 0.05 ) . CONCLUSIONS KC 11458 , in a dose of 8 mg t.d.s . for 8 days , does not accelerate gastric emptying in patients with diabetic gastroparesis . The absence of efficacy may relate to an effect of hyperglycaemia .
17973
Intervention_Pharmacological
KC 11458
17974
Intervention_Pharmacological
KC 11458
17975
Intervention_Pharmacological
KC 11458
17976
Intervention_Pharmacological
KC 11458
17977
Intervention_Control
placebo
17978
Intervention_Pharmacological
KC 11458
17979
Intervention_Pharmacological
KC 11458
17980
Intervention_Control
placebo
17981
Intervention_Pharmacological
KC 11458
17982
Outcome_Physical
gastric emptying
17983
Outcome_Physical
gastric emptying
17984
Outcome_Physical
upper gastrointestinal symptoms
17985
Outcome_Physical
solid gastric emptying
17986
Outcome_Physical
blood glucose concentration
17987
Outcome_Physical
gastric emptying
17988
Participant_Condition
healthy humans .
17989
Participant_Sample-size
Twenty-nine
17990
Participant_Sample-size
6
17991
Participant_Sample-size
23
17992
Participant_Condition
gastroparesis