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document
Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction : a double-blinded , prospective , randomized , controlled trial . PURPOSE To evaluate the suppressive effect of intravenous dezocine on fentanyl-induced cough during the induction of general anesthesia . METHODS A total of 120 patients , American Society of Anesthesiologists ( ASA ) physical status I-II , were randomized into two equally sized groups ( n = 60 ) . These two groups were given either intravenous dezocine 0.1 mg/kg or a matching placebo ( equal volume of 0.9 % saline ) 10 min before the induction of general anesthesia . Patients were induced with midazolam 0.1 mg/kg , fentanyl 5 μg/kg , propofol 1-1.5 mg/kg , and suxamethonium 1.5 mg/kg . The injection time of fentanyl was less than 2 s in all patients . The occurrence of cough was recorded 2 min after fentanyl bolus . RESULTS No patient in the dezocine group had cough , and 42 patients in the control group had cough . This difference was statistically different between these two groups ( P = 0.000 ) . CONCLUSION These results demonstrate that intravenous dezocine 0.1 mg/kg 10 min prior to induction was effective in suppressing fentanyl-induced cough in our patients .
51868
Intervention_Pharmacological
dezocine
51869
Intervention_Pharmacological
dezocine
51870
Intervention_Pharmacological
intravenous dezocine
51871
Intervention_Control
matching placebo
51872
Intervention_Pharmacological
fentanyl
51873
Intervention_Pharmacological
suxamethonium
51874
Outcome_Physical
cough
51875
Outcome_Physical
cough