80402
document
[ Dose-effect relationship of isosorbide dinitrate in the treatment of angina pectoris ( author 's transl ) ] . Fifteen males with angiographic evidence of coronary heart disease and stable , exercise-induced angina pectoris were given placebo or isosorbide dinitrate ( ISDN ) in a dialy dose of 30 mg , 120 mg , 240 mg and 480 mg in a randomized single-blind trial . The daily doses were given as a single oral dose of 5 mg , 20 mg , 40 mg and 80 mg tablets . Each dose and placebo was given for seven days . On the seventh day an exercise ECG of standardized level and duration of exercise was recorded . The ischaemia response in the ECG revealed a dose-dependent reduction by 28 % ( 5 mg ISDN ) , 43 % ( 20 mg ) , 60 % ( 40 mg ) and 73 % ( 80 mg ) . The number of anginal attacks similarly fell parallel to dose . Plasma level of ISDN and the mononitrates , measured one and four hours after drug intake , rose almost linearly in relation to dose . Oral ISDN thus has a dose-dependent effect on the frequency of angina and ischaemia parameters during ergometric exercise . The protracted anti-anginal effect of ISDN is largely due to its metabolites . At high doses there is presumably an added effect of the high blood level of the basic substance.U
80403
Intervention_Pharmacological
isosorbide dinitrate
80404
Intervention_Control
placebo
80405
Intervention_Pharmacological
isosorbide dinitrate ( ISDN )
80406
Outcome_Physical
exercise ECG
80407
Outcome_Other
duration of exercise
80408
Outcome_Physical
ischaemia
80409
Outcome_Other
reduction
80410
Outcome_Physical
number of anginal attacks
80411
Outcome_Physical
Plasma level of ISDN and the mononitrates
80412
Outcome_Physical
frequency of angina and ischaemia parameters
80413
Outcome_Physical
anti-anginal effect