79815
document
Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia , respiration and sedation . Interactions between morphine and methotrimeprazine have been studied in mice and man with respect to analgesia or antinociceptive activity , respiratory effects and sedation . The volunteer study was a double-blind cross-over trial with 10 volunteers . In mice , methotrimeprazine only possessed antinociceptive activity in doses which caused marked sedation . However , small non-sedative doses of methotrimeprazine potentiated the analgesic action of morphine . The volunteer study did not confirm this finding in man . Methotrimeprazine 7.5 mg i.m . caused significant sedation , but did not alter the effects of morphine 5 mg on pain threshold or ventilatory response to carbon dioxide .
79816
Intervention_Pharmacological
morphine
79817
Intervention_Pharmacological
methotrimeprazine
79818
Intervention_Pharmacological
morphine
79819
Intervention_Pharmacological
methotrimeprazine
79820
Intervention_Pharmacological
methotrimeprazine
79821
Intervention_Pharmacological
Methotrimeprazine
79822
Intervention_Pharmacological
morphine
79823
Outcome_Physical
analgesia , respiration and sedation
79824
Outcome_Physical
analgesia or antinociceptive activity
79825
Outcome_Physical
respiratory effects
79826
Outcome_Physical
sedation
79827
Outcome_Physical
antinociceptive activity
79828
Outcome_Physical
marked sedation
79829
Outcome_Pain
analgesic action of morphine
79830
Outcome_Physical
significant sedation
79831
Outcome_Pain
pain threshold
79832
Outcome_Physical
ventilatory response
79833
Participant_Sex
man
79834
Participant_Sex
man
79835
Participant_Sample-size
10 volunteers