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Evaluation of umbilical cord serum therapy for persistent corneal epithelial defects . AIMS To evaluate umbilical cord serum therapy as a means of promoting the healing of persistent corneal epithelial defects . METHODS Umbilical cord serum or autologous serum drops were used to promote the healing of persistent epithelial defects . The study design was a prospective randomised controlled clinical trial . 60 eyes of 59 patients were divided into two groups , 31 in the cord serum group and 29 in the autologous serum control group . Epithelial defects measuring at least 2 mm in linear dimension resistant to conventional medical management were included . Serial measurements of the size of the epithelial defects-namely , two maximum linear dimensions perpendicular to each other , and the area and perimeter was done at start of therapy and follow up days 3 , 7 , 14 , 21 . Rate of healing of the epithelial defects were measured as percentage decrease from the baseline parameter at each subsequent follow up . The data were analysed by the non-parametric Wilcoxon rank sum test using STATA 7.0 . RESULTS The median percentage decrease in the size of the epithelial defect was significantly greater in the cord serum group at days 7 , 14 and 21 ( p < 0.05 ) when measured in terms of the area and perimeter . A greater number of patients showed complete re-epithelialisation with umbilical cord serum ( n = 18 ) than with autologous serum ( n = 11 ) ( Pearson chi = 0.19 ) . None of the patients reported any side effects or discomfort with either treatment . CONCLUSIONS Umbilical cord serum leads to faster healing of the persistent corneal epithelial defects refractory to all medical management compared to autologous serum .
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Intervention_Pharmacological
umbilical cord serum therapy
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Intervention_Pharmacological
umbilical cord serum therapy
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Intervention_Pharmacological
Umbilical cord serum
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Intervention_Pharmacological
autologous serum drops
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Intervention_Pharmacological
cord serum
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Intervention_Control
autologous serum control
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Intervention_Pharmacological
cord serum
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Intervention_Pharmacological
cord serum
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Intervention_Pharmacological
Umbilical cord serum
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Intervention_Pharmacological
autologous serum
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Outcome_Physical
persistent corneal epithelial defects
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Outcome_Physical
persistent epithelial defects
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Outcome_Physical
Rate of healing of the epithelial defects
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Outcome_Physical
decrease in the size of the epithelial defect
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Outcome_Physical
complete re-epithelialisation
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Outcome_Physical
faster healing of the persistent corneal epithelial defects
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Participant_Condition
persistent corneal epithelial defects .
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Participant_Condition
persistent corneal epithelial defects .