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document
Absence of cervical radiation myelitis after hyperfractionated radiation therapy with and without concurrent chemotherapy for locally advanced , unresectable , nonmetastatic squamous cell carcinoma of the head and neck . PURPOSE To evaluate the risk of developing radiation myelitis after a cervical spinal cord dose of 50.6 Gy given via 1.1 Gy b.i.d . fractionation during a prospective , randomised trial of hyperfractionated radiation therapy ( HFX RT ) to a total dose of 77 Gy given in 70 fractions of 1.1 Gy b.i.d. , with and without concurrent low-dose , daily cisplatin ( CDDP ) for head and neck cancer . METHODS Of 130 patients with locally advanced , unresectable , nonmetastatic squamous cell carcinoma of the head and neck ( SCC H & N ) who entered a prospective , randomised trial , 101 patients received 50.6 Gy to a portion of their spinal cord and survived > 1 year following the beginning of therapy . Forty-five patients were treated with HFX RT alone and fifty-six patients also received CDDP . RESULTS None of these 101 patients developed cervical radiation myelitis . Therefore , it was not possible to investigate the influence of potentially contributing factors on the occurrence of radiation myelitis , such as interfraction interval , cord length , and administration of concurrent CDDP . CONCLUSIONS Given the increasing number of studies with both altered fractionated regimens and concurrent radio-chemotherapy in SCC H & N , new studies with more patients are needed to gain better insight into the risks of developing cervical radiation myelitis .
7548
Intervention_Physical
hyperfractionated radiation therapy
7549
Intervention_Physical
concurrent chemotherapy
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Intervention_Pharmacological
Gy
7551
Intervention_Physical
hyperfractionated radiation therapy
7552
Intervention_Pharmacological
Gy
7553
Intervention_Pharmacological
cisplatin ( CDDP )
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Intervention_Pharmacological
50.6 Gy
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Intervention_Physical
HFX RT
7556
Intervention_Pharmacological
CDDP
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Intervention_Pharmacological
CDDP
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Intervention_Physical
radio-chemotherapy
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Outcome_Physical
cervical radiation myelitis
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Outcome_Physical
risk of developing radiation myelitis
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Outcome_Physical
cervical radiation myelitis .
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Outcome_Physical
occurrence of radiation myelitis
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Outcome_Physical
interfraction interval , cord length , and administration of concurrent CDDP .
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Outcome_Physical
cervical radiation myelitis
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Participant_Condition
locally advanced , unresectable , nonmetastatic squamous cell carcinoma of the head and neck
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Participant_Condition
head and neck cancer
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Participant_Sample-size
130