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document
FloSeal hemostatic matrix in persistent epistaxis : prospective clinical trial . OBJECTIVE Although most cases of epistaxis are managed conservatively , occasionally they can progress to significant hemorrhage requiring more involved management or surgery . Endoscopic ligation surgery is the current institutional standard of care for patients who fail conservative management . However , surgical ligation requires availability of surgical resources and patients who are able to withstand an anesthetic . This study 's objective was to determine the efficacy of FloSeal hemostatic matrix ( Baxter Healthcare Corporation , Hayward , CA ) in epistaxis refractory to nasal packing . METHODS A prospective clinical trial was conducted on epistaxis patients whose nasal hemorrhage persisted despite adequate nasal packing by the otolaryngology-head and neck surgery team . Once enrolled , patients are given a trial of intranasal FloSeal hemostatic matrix to abort the epistaxis . Should this fail , patients then proceed with surgical clipping . RESULTS Our prospective cohort demonstrated significant success in 80 % of patients with persistent epistaxis , who would have otherwise been taken to the operating theatre , avoiding the need for further surgical intervention . The majority of enrolled patients with persistent nasal hemorrhage were adequately managed with the hemostatic matrix alone and were discharged from hospital in a timeframe comparable to that of surgical managment . CONCLUSIONS This study revealed a highly effective tool in the otolaryngologist 's management of persistent epistaxis . Given the ease of use , decreased morbidity to the patient , and cost-effectiveness , FloSeal hemostatic matrix could change clinical practice in managing this common condition .
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Intervention_Pharmacological
FloSeal hemostatic matrix
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Intervention_Pharmacological
FloSeal hemostatic matrix
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Intervention_Pharmacological
FloSeal hemostatic matrix
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Intervention_Pharmacological
FloSeal hemostatic matrix
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Outcome_Other
surgical intervention
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Outcome_Other
discharged from hospital
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Participant_Condition
persistent epistaxis :
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Participant_Condition
80 % of patients with persistent epistaxis