57638
document
Myocardial extracellular volume by cardiac magnetic resonance imaging in patients treated with anthracycline-based chemotherapy . We aimed to determine whether the myocardial extracellular volume ( ECV ) , measured using T1 measurements obtained during cardiac magnetic resonance imaging were increased in patients treated with anthracyclines . We performed cardiac magnetic resonance imaging and echocardiography and measured the ECV in 42 patients treated with anthracyclines . The data from the cardiac magnetic resonance study were compared to those from healthy volunteers . The anthracycline-treated cohort consisted of 21 men and 21 women with a mean age of 55 ± 17 years , who presented a median of 84 months after chemotherapy with a cumulative anthracycline exposure of 282 ± 65 mg/m ( 2 ) and a mean left ventricular ejection fraction of 52 ± 12 % . The ECV was elevated in the anthracycline-treated patients compared to the age- and gender-matched controls ( 0.36 ± 0.03 vs 0.28 ± 0.02 , p < 0.001 ) . A positive association was found between the ECV and left atrial volume ( ECV vs indexed left atrial volume , r = 0.65 , p < 0.001 ) , and negative association was found between the ECV and diastolic function ( E ' lateral , r = -0.64 , p < 0.001 ) . In conclusion , the myocardial ECV is elevated in patients with previous anthracycline treatment and is associated with the diastolic function and increased atrial volumes .
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Intervention_Pharmacological
anthracyclines
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Intervention_Physical
cardiac magnetic resonance imaging and echocardiography and measured the ECV
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Intervention_Pharmacological
anthracyclines .
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Outcome_Physical
myocardial extracellular volume ( ECV )
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Outcome_Physical
T1 measurements
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Outcome_Physical
ECV
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Participant_Condition
patients treated with anthracycline-based chemotherapy
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Participant_Condition
patients treated with anthracyclines
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Participant_Sample-size
42 patients
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Participant_Condition
treated with anthracyclines
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Participant_Condition
healthy volunteers
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Participant_Sample-size
21
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Participant_Sex
men
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Participant_Sample-size
21
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Participant_Sex
women
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Participant_Age
age of 55 ± 17 years
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Participant_Condition
who presented a median of 84 months after chemotherapy with a cumulative anthracycline exposure of 282 ± 65 mg/m ( 2 )
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Participant_Condition
a mean left ventricular ejection fraction of 52
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Participant_Condition
elevated in patients with previous anthracycline treatment