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document
Sodium-potassium pump activity in white blood cells from children with an increased risk of developing hypertension -- The Odense Schoolchild Study . We have measured the capacity of the sodium-potassium pump , as assessed by 86rubidium uptake and the number of [ 3H ] -ouabain binding sites on white blood cells , in children aged 9-11 years , partly cross-sectionally and partly longitudinally after a physical training programme . Children from a hypertensive subgroup comprising the upper 5 % of the blood pressure distribution and children from a randomly selected normotensive subgroup were eligible for the study . In the cross-sectional study 40 children from the hypertensive subgroup and 40 children from the normotensive subgroup were evaluated . A significant increase in 86rubidium uptake was present in boys as compared to girls . After adjustment for differences in sexual maturation the observed significant difference disappeared . Important correlates of pump activity were height , plasma glucose , and physical fitness . In the training study 10 boys from the hypertensive subgroup and 10 boys from the normotensive subgroup were also evaluated after eight months of physical training . A significant fall in 86rubidium uptake was observed . No control group was examined and probably the changes reflect some effects of sexual maturation on cation handling of cells . These results indicate a significant effect of sexual maturation in capacity of sodium-potassium pump in children .
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Intervention_Pharmacological
Sodium-potassium pump activity
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Intervention_Pharmacological
sodium-potassium pump
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Intervention_Educational
physical training programme .
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Intervention_Physical
pump activity
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Intervention_Pharmacological
sodium-potassium pump
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Outcome_Physical
86rubidium uptake
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Outcome_Physical
86rubidium uptake
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Outcome_Physical
sexual maturation on cation handling of cells
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Outcome_Physical
sexual maturation in capacity of sodium-potassium pump
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Participant_Age
children
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Participant_Condition
hypertension
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Participant_Age
children
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Participant_Age
9-11
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Participant_Age
Children
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Participant_Condition
hypertensive
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Participant_Age
children
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Participant_Sample-size
40
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Participant_Age
children
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Participant_Condition
hypertensive
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Participant_Sample-size
40
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Participant_Sample-size
10
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Participant_Sex
boys
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Participant_Condition
hypertensive
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Participant_Sample-size
10
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Participant_Sex
boys
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Participant_Age
children