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document
[ Intra-arterial chemotherapy in advanced ovarian cancers . 2 . Therapeutic results in relation to prognostic factors ] . 85 patients with advanced ovarian carcinomas were treated either intra-arterially with MTX and 5-FU , later systemically with the CMFV-combination ( therapy arm A ) or only systemically ( therapy arm B ) after randomization . The achieved rates of remission and survival time showed an obvious dependence on the histological type of tumor and on the degree of differentiation . Whereas the results of the treatment were nearly identical in both groups of treatment with badly differentiated carcinomas , a significant improvement could be achieved by the initial local treatment of well and moderately differentiated malignancies . More than one third of the cases of advanced tumors were operable by local chemotherapy . Thus the survival time could be extended . The intra-arterial chemotherapy represents an expensive , but effective method of treatment of advanced ovarian carcinomas .
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Intervention_Pharmacological
Intra-arterial chemotherapy
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Intervention_Pharmacological
intra-arterially with MTX
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Intervention_Physical
and
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Intervention_Pharmacological
5-FU
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Intervention_Pharmacological
systemically with the CMFV-combination
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Intervention_Physical
only systemically
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Intervention_Pharmacological
intra-arterial chemotherapy
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Outcome_Mortality
rates of remission and survival time
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Outcome_Mortality
survival time
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Participant_Condition
85 patients with advanced ovarian carcinomas