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document
The Impact of Pupillary Dilation on Intraocular Pressure and Anterior Segment Morphology in Subjects with and without Pseudoexfoliation . PURPOSE To investigate the change in pre- and post-dilation anterior segment parameters and intraocular pressure ( IOP ) of patients with and without pseudoexfoliation , after topical application of phenylephrine HCl 10 % and tropicamide 1 % . MATERIALS AND METHODS Totally 129 eyes of 129 patients were included in the study . Of the 129 eyes ; 31 had pseudoexfoliation syndrome ( PXS ) , 37 had pseudoexfoliation glaucoma ( PXG ) , 31 eyes were the fellow eyes of subjects with unilateral pseudoexfoliation syndrome ( subclinical PXS ) and 30 eyes were the eyes of subjects without PXS ( controls ) . Patients underwent Pentacam analysis and IOP measurement before and after dilation . The changes in IOP , anterior chamber depth ( ACD ) , anterior chamber volume ( ACV ) , anterior chamber angle ( ACA ) , central corneal thickness ( CCT ) and pupillary diameter ( PD ) were investigated 30 min after the application of mydriatic agents . RESULTS The mean change of IOP in eyes with PXS , in eyes with PXG , in eyes with subclinical PXS and eyes of control subjects were 1.45 ± 2.03 mmhg , 0.27 ± 2.25 mmhg , -0.35 ± 1.58 mmHg and -1.06 ± 1.59mmHg , respectively . Post-dilation IOP values were lower ( p = 0.001 ) in eyes of controls but higher ( p < 0.001 ) in eyes of PXS than the pre-dilation levels . All patients exhibited statistically significant increase in ACD , ACV and PD after the dilation procedure ( p < 0.001 ) . Additionally , post dilation CCT values were significantly lower than pre-dilation values in all groups ; the difference was statistically significant only for eyes with PXG , eyes with subclinical PXS and eyes of controls . CONCLUSION Eyes with PXS had a higher tendency of IOP elevation after pupillary dilation . Eyes with subclinical PXS , however , exhibited a minor increase in IOP , reflecting the asymmetrical character of the disease . Anti-glaucoma medications may have blunted any IOP elevation induced by pupillary dilation in eyes with PXG .
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Intervention_Physical
Pupillary Dilation
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Intervention_Pharmacological
topical application of phenylephrine HCl 10 %
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Intervention_Pharmacological
tropicamide 1 %
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Outcome_Physical
changes in IOP , anterior chamber depth ( ACD ) , anterior chamber volume ( ACV ) , anterior chamber angle ( ACA ) , central corneal thickness ( CCT ) and pupillary diameter ( PD )
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Outcome_Physical
mean change of IOP
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Participant_Condition
Subjects with and without Pseudoexfoliation .
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Participant_Condition
patients with and without pseudoexfoliation
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Participant_Sample-size
129 patients
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Participant_Sample-size
129
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Participant_Condition
pseudoexfoliation syndrome
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Participant_Condition
pseudoexfoliation glaucoma
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Participant_Condition
unilateral pseudoexfoliation syndrome
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Participant_Condition
without PXS ( controls