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document
Hypericum treatment of mild depressions with somatic symptoms . In a randomized , placebo-controlled , double-blind study , 39 patients with depression with somatic symptoms were treated with hypericum extract LI 160 . The therapy lasted for 4 weeks ; the dosage was 300 mg three times daily . At the onset of the study as well as after 2 and 4 weeks , the following criteria were analyzed : HAMD , B-L , CGI , and vegetative symptoms . The results show a significant improvement in the active treatment group at the 5 % level as compared to placebo . Seventy percent of the patients treated with LI 160 were free of symptoms after 4 weeks . Typical symptoms of the depression such as lack of activity , tiredness , fatigue , and disturbed sleep , were especially responsive . In no case were any undesirable side effects observed .
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Intervention_Pharmacological
Hypericum treatment
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
hypericum extract LI 160
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Outcome_Other
significant improvement
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Outcome_Physical
symptoms
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Outcome_Mental
lack of activity
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Outcome_Physical
tiredness
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Outcome_Mental
fatigue
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Outcome_Mental
disturbed sleep
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Outcome_Adverse-effects
undesirable side effects
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Participant_Condition
mild depressions with somatic symptoms .
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Participant_Condition
39 patients with depression with somatic symptoms