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document
Antihistamines do not inhibit the wheal induced by the intradermal injection of autologous serum in resistant chronic idiopathic urticaria . Some patients with chronic idiopathic urticaria ( CIU ) are resistant to conventional doses of antihistamines ( AHs ) . This study was designed to check whether the skin wheal and flare reaction produced by the intradermal injection of autologous serum ( AS ) and by histamine differs in AH-resistant and AH responder CIU patients . CIU patients with treatment failure under fexofenadine at 180 mg q.d . increased their daily dose of AH to 4 tablets daily . Those with significant improvement of urticaria activity score under fexofenadine at 180 mg were included in the CIU group . Subjects with treatment failure despite a full 8-week fourfold fexofenadine treatment were included in the resistant CIU ( R-CIU group ) . The control group consisted of sex- and age-matched patents with allergic rhinitis . The AS skin test and intradermal histamine-induced wheal and flare reaction were performed at baseline ( without AH ) , after 8 and 16 weeks ( under AH treatment ) . Forty-six subjects were included in the CIU group , 21 were in the R-CIU group , and 44 were in the control group . Under AH therapy , the skin reaction to intradermal histamine injection was significantly diminished in all study groups . In the R-CIU group , fexofenadine at 180 mg did not suppress AS-induced wheal reaction ( 5.96 ± 2.25 mm ; p = 0.85 ) , and with a fourfold AH dose some reduction of AS-induced wheal ( 3.79 ± 1.74 mm ; p = 0.008 ) was observed but remained larger than in the CIU ( 2.31 ± 1.12 ; p = 0.006 ) and control groups ( 2.52 ± 1.36 ; p = 0.037 ) . AHs do not inhibit the wheal induced by the intradermal injection of AS in R-CIU .
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Intervention_Pharmacological
Antihistamines
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Intervention_Pharmacological
antihistamines ( AHs )
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Intervention_Pharmacological
autologous serum ( AS )
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Intervention_Pharmacological
histamine
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Intervention_Pharmacological
fexofenadine
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Intervention_Pharmacological
fexofenadine
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Intervention_Pharmacological
fexofenadine
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Intervention_Pharmacological
histamine-induced
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Intervention_Pharmacological
fexofenadine
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Outcome_Adverse-effects
skin wheal and flare reaction
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Outcome_Adverse-effects
skin reaction to intradermal histamine injection
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Outcome_Adverse-effects
AS-induced wheal reaction
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Participant_Condition
AH-resistant and AH responder CIU patients .