33814
document
Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins : a randomized trial . OBJECTIVE To evaluate the effectiveness of a GnRH antagonist in preventing premature LH surge under a letrozole and gonadotropin protocol . DESIGN Prospective , randomized clinical trial . SETTING A teaching hospital and tertiary medical center . PATIENT ( S ) Sixty-one patients were randomly assigned into two letrozole and gonadotropin-treated groups . These were distinguished by the absence ( group I ) or presence ( group II ) of supplementation with 0.25 mg of cetrorelix . INTERVENTION ( S ) Controlled ovarian stimulation with letrozole and gonadotropins , cetrorelix and intrauterine insemination . MAIN OUTCOME MEASURE ( S ) Rate of premature LH surge . RESULT ( S ) Compared with group I , the rate of premature LH surge was statistically significantly lower for group II ( 43.4 % [ 13/30 ] vs. 19.4 % [ 6/31 ] ) , but the amount of gonadotropins used was statistically significantly higher ( 817.5 +/- 28.5 vs. 907.5 +/- 27.3 IU ) . Patients with premature LH surge had a statistically significantly lower pregnancy rate ( 21.4 % [ 9/42 ] vs. 0 [ 0/18 ] ) relative to their unaffected counterparts . CONCLUSION ( S ) A flexible protocol of 0.25 mg of cetrorelix for IUI cycles appears to suppress the rate of premature LH surge during ovarian stimulation with letrozole and gonadotropins . However , the incidence of premature LH surge remains too high , and modification will be necessary before the application of cetrorelix to IVF treatment .
33815
Intervention_Pharmacological
cetrorelix
33816
Intervention_Pharmacological
two letrozole and gonadotropin-treated
33817
Intervention_Pharmacological
absence ( group I ) or presence ( group II ) of supplementation with 0.25 mg of cetrorelix
33818
Intervention_Pharmacological
letrozole and gonadotropins , cetrorelix
33819
Intervention_Pharmacological
cetrorelix
33820
Outcome_Physical
premature luteinizing hormone surge
33821
Outcome_Physical
premature LH surge
33822
Outcome_Physical
Rate of premature LH surge .
33823
Outcome_Physical
rate of premature LH surge
33824
Outcome_Other
amount of gonadotropins
33825
Outcome_Physical
premature LH surge
33826
Outcome_Physical
pregnancy rate
33827
Outcome_Physical
premature LH surge
33828
Outcome_Physical
premature LH surge
33829
Participant_Sample-size
Sixty-one