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document
Electrical sources of P300 event-related brain potentials revealed by low resolution electromagnetic tomography . 2 . Effects of nootropic therapy in age-associated memory impairment . In a double-blind , placebo-controlled study the effects of Actovegin on frontal and parietal electrical P300 sources revealed by low resolution electromagnetic tomography ( LORETA ) were studied in age-associated memory impairment ( AAMI ) patients . Actovegin is a protein-free metabolically active hemoderivative improving oxygen and glucose utilization . Each patient had , in randomized order , a treatment of 2 weeks with 250 ml 20 % Actovegin and 250 ml placebo daily . Auditory ERPs were recorded before and 5 h after drug administration on day 1 ( acute effect ) and on day 15 ( subacute and superimposed effect ) . Compared to age- and sex-matched normal controls , AAMI patients showed a trend towards P300 latency prolongation and a significantly reduced P300 global field power ( GFP ) . Maximal LORETA source strength did not differ from controls . After Actovegin parietal P300 scalp amplitudes increased , while frontal and temporal amplitudes decreased as compared to placebo . This increase in hilliness , measured by the GFP , was significant . Moreover , the parietal P300 source strength increased after acute , subacute and superimposed infusion of Actovegin as compared to placebo . This may reflect improved availability of cognitive processing resources in the parietal cortex , an area that on the one hand plays an important role in fundamental aspects of attention and on the other hand has been found to be functionally impaired in dementia .
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Intervention_Pharmacological
nootropic therapy
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Intervention_Pharmacological
Actovegin
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Intervention_Pharmacological
2 weeks with 250 ml 20 % Actovegin
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Intervention_Control
250 ml placebo
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Intervention_Physical
Auditory ERPs
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Intervention_Control
placebo
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Intervention_Control
placebo
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Outcome_Other
P300 latency prolongation
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Outcome_Other
P300 global field power
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Outcome_Other
Maximal LORETA source strength
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Outcome_Physical
Actovegin parietal P300 scalp amplitudes
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Outcome_Physical
frontal and temporal amplitudes
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Outcome_Physical
hilliness
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Outcome_Other
parietal P300 source strength
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Participant_Condition
age-associated memory impairment