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document
Early versus late hCG administration to trigger ovulation in mild stimulated IUI cycles : a randomized clinical trial . OBJECTIVES To verify non-inferiority of the clinical pregnancy rate of Early hCG administration ( leading follicle sizes within 16.0-16.9 mm in diameter ) compared to Late hCG administration ( leading follicle sizes within 18.0-18.9 mm in diameter ) . STUDY DESIGN Prospective randomized trial . Six hundred and twelve infertile women candidates for intrauterine insemination ( IUI ) received HP-hMG 75 IU/day SC from cycle days 4 to 8 and then as per ovarian response . Ovulation was randomly triggered ( hCG 5000 IU , IM ) when the leading follicle diameter ranged between either 16.0 and 16.9 mm ( Early hCG group , n=227 ) or 18.0 and 18.9 mm ( Late hCG group , n=207 ) and IUI was performed approximately 36 h later . RESULTS Whereas population and sperm characteristics were comparable in both groups , the number of follicles ≥ 14 mm in diameter ( P < 0.007 ) and serum estradiol levels ( P < 0.001 ) on the day of hCG were lower in the Early versus the Late hCG groups . Clinical ( 11.9 % versus 12.1 % ) and ongoing ( 11.0 % versus 8.6 % ) pregnancy rates per randomized women were similar in the two groups and statistical non-inferiority of clinical and ongoing pregnancy rates was demonstrated . CONCLUSION These results suggest that hCG administered when the largest follicle size reaches 16.0-16.9 mm leads to similar clinical and ongoing pregnancy rates as when it reaches 18.0-18.9 mm in IUI cycles .
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Intervention_Pharmacological
hCG administration
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Intervention_Pharmacological
Early hCG administration
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Intervention_Pharmacological
Late hCG administration
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Intervention_Physical
HP-hMG
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Intervention_Pharmacological
hCG
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Outcome_Physical
population and sperm characteristics
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Outcome_Physical
number of follicles
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Outcome_Physical
serum estradiol levels
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Outcome_Physical
pregnancy rates