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document
Comparison of epidural tramadol-ropivacaine and fentanyl-ropivacaine for labor analgesia : a prospective randomized study . BACKGROUND To test the hypothesis that 5 mg/mL tramadol is superior to 3 ? g/mL fentanyl when combined with 0.125 % ropivacaine in parturients undergoing labor during epidural analgesia . METHODS Sixty-one parturients undergoing labor selected for delivery with epidural analgesia were randomized into two groups : Group tramadol ( 0.125 % ropivacaine plus tramadol 5 mg/mL ) and Group fentanyl ( 0.125 % ropivacaine plus fentanyl 3 ug/mL ) . Hemodynamics , rate of cesarean delivery , sensory block level , Bromage motor scale scores , instrument-assisted delivery , oxytocin use , visual analog scale ( VAS ) scores , Apgar scores , umbilical cord artery gas analysis , and maternal side-effects including nausea , vomiting , pruritus , urinary retention , shivering , hypotension , and respiratory depression were recorded . RESULTS The two groups had no significant differences with respect to maternal hemodynamics , neonatal heart rate , VAS scores , rate of cesarean delivery , sensory block level , Bromage motor scale scores , instrument-assisted delivery , oxytocin use , hypotension , nausea , vomiting , and respiratory depression ( p > 0.05 ) . The incidence of pruritus , shivering , and urinary retention were more commonly observed in Group fentanyl despite there was no significant difference between the two groups . Umbilical artery pH was significantly lower while PCO ( 2 ) was higher in Group fentanyl than Group tramadol ( p = 0.003 and p = 0.026 , respectively ) . Birth-weight , umbilical artery PO ( 2 ) and base deficit , and Apgar scores at 1 and 5 min were comparable between the two groups ( p > 0.05 ) . CONCLUSIONS Our observations suggest that tramadol seems to be a safe alternative to fentanyl for labor analgesia due to its similar analgesic efficacy .
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Intervention_Pharmacological
epidural tramadol-ropivacaine
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Intervention_Pharmacological
fentanyl-ropivacaine
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Intervention_Pharmacological
tramadol
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Intervention_Pharmacological
fentanyl
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Intervention_Pharmacological
ropivacaine
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Intervention_Pharmacological
tramadol ( 0.125 % ropivacaine plus tramadol 5 mg/mL )
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Intervention_Pharmacological
fentanyl ( 0.125 % ropivacaine plus fentanyl 3 ug/mL )
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Intervention_Pharmacological
fentanyl
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Intervention_Pharmacological
tramadol
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Intervention_Pharmacological
tramadol
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Intervention_Pharmacological
fentanyl
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Outcome_Physical
Hemodynamics
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Outcome_Other
rate of cesarean delivery
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Outcome_Other
sensory block level ,
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Outcome_Physical
Bromage motor scale scores
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Outcome_Other
instrument-assisted delivery
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Outcome_Other
oxytocin use
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Outcome_Pain
visual analog scale ( VAS ) scores
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Outcome_Physical
Apgar scores
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Outcome_Physical
umbilical cord artery
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Outcome_Physical
analysis
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Outcome_Adverse-effects
maternal side-effects including nausea , vomiting , pruritus , urinary retention , shivering , hypotension , and respiratory depression
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Outcome_Physical
maternal hemodynamics
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Outcome_Physical
neonatal heart rate
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Outcome_Pain
VAS scores
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Outcome_Other
rate of cesarean delivery
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Outcome_Physical
sensory block level
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Outcome_Physical
Bromage motor scale scores
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Outcome_Other
instrument-assisted delivery
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Outcome_Other
oxytocin use
52685
Outcome_Adverse-effects
hypotension
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Outcome_Adverse-effects
nausea
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Outcome_Adverse-effects
vomiting
52688
Outcome_Adverse-effects
respiratory depression
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Outcome_Adverse-effects
pruritus , shivering , and urinary retention
52690
Outcome_Physical
Umbilical artery pH
52691
Outcome_Physical
Birth-weight
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Outcome_Physical
umbilical artery PO ( 2 )
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Outcome_Physical
base deficit
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Outcome_Physical
Apgar scores