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document
Comparison of outcome of labetalol or hydralazine therapy during hypertension in pregnancy in very low birth weight infants . Ninety-seven women with moderate to severe preeclampsia ( PE ) were allocated at random to labetalol or hydralazine treatment . Of these , 22 women with severe PE gave birth to neonates with VLBW ( very low birth weight < or = 1500 g ) . Seven were allocated to labetalol treatment ( Group A ) , eight to hydralazine treatment ( Group B ) and seven women received both drugs due to poor blood pressure control with a single drug therapy ( Group C ) . No difference in cesarean section rate or in the indication for operative delivery could be seen . Gestational age was 29.9 weeks ( 25.4-32.5 ) in Group A , 28.6 weeks ( 26.6-33.4 ) in Group B and 27.3 weeks ( 26.7-31.1 ) in Group C ( median and range ) . Birth weight did not differ between groups and 13 of the 22 infants weighed below 1000 g. There was a tendency to lower Apgar scores at five minutes in the hydralazine group . Time spent in the neonatal intensive care unit did not differ between groups . Five of the 11 neonates with gestational age ( GA ) < or = 28 weeks and three of the seven neonates in GA 29-30 weeks died . Neither the number of infants requiring intermittent positive pressure ventilation or duration of O2- treatment , nor number of infants with respiratory distress syndrome differed between groups . We did not find any difference in the outcome of the VLBW infants when the hypertensive mother had been treated with either hydralazine or labetalol .
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Intervention_Pharmacological
labetalol
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Intervention_Pharmacological
hydralazine
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Intervention_Pharmacological
labetalol or hydralazine
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Intervention_Pharmacological
labetalol treatment ( Group A )
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Intervention_Pharmacological
hydralazine treatment ( Group B ) and
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Intervention_Pharmacological
received both drugs due to poor blood pressure control with a single drug therapy
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Intervention_Pharmacological
hydralazine
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Intervention_Pharmacological
labetalol
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Outcome_Physical
cesarean section rate
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Outcome_Physical
indication for operative delivery
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Outcome_Physical
Gestational age
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Outcome_Physical
Birth weight
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Outcome_Physical
Apgar scores
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Outcome_Other
Time spent in the neonatal intensive care unit
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Outcome_Mortality
died
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Outcome_Other
number of infants
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Outcome_Physical
requiring intermittent positive pressure ventilation
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Outcome_Other
duration of O2- treatment
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Outcome_Physical
number of infants with respiratory distress syndrome
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Participant_Condition
labetalol or hydralazine therapy during hypertension in pregnancy in very low birth weight infants . Ninety-seven women with moderate to severe preeclampsia ( PE )
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Participant_Condition
infants