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document
Multiorgan protection of remote ischemic perconditioning in valve replacement surgery . BACKGROUND Remote ischemic perconditioning ( RIPerc ) is a new alternative of remote ischemic conditioning and has not been well studied . RIPerc attenuates myocardial injury when applied during cardiac surgery . However , its protective effects on other organs remain unknown . MATERIALS AND METHODS Patients with rheumatic heart disease undergoing valve replacement surgery were randomized into the RIPerc group ( n = 101 ) or the control group ( n = 100 ) . RIPerc was achieved by three cycles of 5-min ischemia-5-min reperfusion in the right thigh during surgery . Clinical data and the levels of injury biomarkers for the heart , lungs , liver , and kidneys within 48 h after surgery were compared using one-way or repeated measurement analysis of variance . RESULTS In the RIPerc group , the release of serum cardiac troponin I ( 128.68 ± 102.56 versus 172.33 ± 184.38 , P = 0.04 ) and the inotropic score ( 96.4 ± 73.8 versus 121.5 ± 89.6 , P = 0.032 ) decreased compared with that of the control ; postoperative drainage ( 458.2 ± 264.2 versus 545.1 ± 349.0 ml , P = 0.048 ) and the incidence of acute lung injury was reduced ( 36.6 % versus 51 % , P = 0.04 ) , and the extent of hyperbilirubinemia was also attenuated . No significant difference was observed in the levels of biomarkers for renal injury and systemic inflammation response . CONCLUSIONS RIPerc applied during the valve replacement surgery induced multiple beneficial effects postoperatively including reduced drainage and myocardial damage , lower incidence of acute lung injury , and attenuated hyperbilirubinemia .
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Intervention_Surgical
remote ischemic perconditioning
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Intervention_Surgical
Remote ischemic perconditioning ( RIPerc
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Intervention_Surgical
RIPerc
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Intervention_Control
control
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Outcome_Physical
surgery . Clinical data
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Outcome_Physical
the levels of injury biomarkers for the heart , lungs , liver , and kidneys
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Outcome_Physical
the release of serum cardiac troponin
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Outcome_Other
P = 0.04 )
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Outcome_Other
the inotropic
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Outcome_Other
that of the control ; postoperative
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Outcome_Physical
545.1 ± 349.0 ml , P = 0.048 )
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Outcome_Adverse-effects
the incidence
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Outcome_Other
P = 0.04 )
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Outcome_Physical
difference was observed in the levels of biomarkers for renal injury and
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Outcome_Physical
valve replacement surgery induced multiple beneficial effects postoperatively including reduced drainage and myocardial damage , lower incidence of acute lung injury , and
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Participant_Condition
valve replacement surgery .
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Participant_Condition
Patients with rheumatic heart disease undergoing valve replacement surgery