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document
[ Metastatic breast cancer : a comparative study of the efficacy of tamoxifen and the sequential administration of tamoxifen and medroxyprogesterone acetate ] . Seventy-nine patients with an histologically proven disseminated breast cancer , never treated before with additive hormonal therapy , entered into a randomized trial between june 1981 and december 1982 . In the first group 44 patients were given continually a daily dose of tamoxifen ( TAM ) of 20 mg/m2 . In the 2nd group 35 patients were given a daily dose of TAM of 20 mg/m2 for 15 days and then an oral daily dose of medroxyprogesterone acetate of 350 mg/m2 for the next 15 days . In both groups I and II , the treatment was stopped at the first manifestation of progression of the disease . The hormonal receptor status was determined in 30 patients of the group I and 23 patients of the group II . An objective response to treatment was observed in 48 per cent of the patients of the group I and 60 per cent of the group II . This difference is not significant ( X2 = 1,05 ) . However , the mean duration of therapeutic response is significantly higher in the group II ( p = 0,01 ) .
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Intervention_Pharmacological
tamoxifen
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Intervention_Pharmacological
tamoxifen
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Intervention_Pharmacological
medroxyprogesterone acetate
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Intervention_Pharmacological
tamoxifen ( TAM )
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Intervention_Pharmacological
TAM
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Intervention_Pharmacological
medroxyprogesterone acetate
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Outcome_Physical
Metastatic breast cancer
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Outcome_Physical
mean
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Outcome_Other
duration of therapeutic response
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Participant_Condition
[ Metastatic breast cancer
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Participant_Sample-size
Seventy-nine
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Participant_Condition
histologically proven disseminated breast cancer
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Participant_Condition
never treated before with additive hormonal therapy