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document
Maternal erythropoietin in singleton pregnancies : a randomized trial on the effect of oral hematinic supplementation . OBJECTIVE Our purpose was to study the effect of hematinic supplementation on the maternal erythropoietin response during singleton pregnancy . STUDY DESIGN In a randomized , double-blind trial 97 patients with a first-trimester hemoglobin level > or = 14.0 gm/dl received either iron and folic acid ( hematinic group , n = 53 ) or a placebo ( n = 44 ) . Serial hemoglobin , hematocrit , and serum erythropoietin were recorded from maternal blood and from cord blood on delivery . Serum ferritin was measured in the first trimester , at 36 weeks ' gestation , and in cord blood . RESULTS In both groups ( 1 ) the mean hemoglobin was lower ( p < 0.01 ) at 40 weeks ' gestation than when first examined and ( 2 ) the mean serum erythropoietin was higher ( p < 0.01 ) . The mean serum ferritin was lower ( p < 0.001 ) in both groups at 36 weeks ' gestation than at presentation but higher ( p = 0.04 ) in the hematinic group than in the placebo group . The mean hemoglobin and hematocrit were similar in the two groups until the third trimester but thereafter were higher ( p < 0.05 ) in the hematinic group . The mean maternal serum erythropoietin was higher ( p < 0.05 ) in the placebo group than in the hematinic group after 24 weeks ' gestation . The mean cord blood hematologic values were similar in the two groups . CONCLUSION Maternal serum erythropoietin increased during pregnancy , but this response was reduced in the third trimester in the hematinic-supplemented group .
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Intervention_Pharmacological
supplementation
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Intervention_Pharmacological
iron and folic acid
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Intervention_Control
placebo
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Outcome_Physical
Maternal erythropoietin
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Outcome_Physical
maternal erythropoietin response
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Outcome_Physical
Serial hemoglobin
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Outcome_Physical
hematocrit
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Outcome_Physical
serum erythropoietin
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Outcome_Physical
Serum ferritin
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Outcome_Physical
mean hemoglobin
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Outcome_Physical
mean serum ferritin
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Outcome_Physical
mean hemoglobin and hematocrit
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Outcome_Physical
mean maternal serum erythropoietin
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Outcome_Physical
mean cord blood hematologic values
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Outcome_Physical
Maternal serum erythropoietin
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Participant_Condition
singleton pregnancies
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Participant_Sample-size
97
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Participant_Sample-size
53
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Participant_Sample-size
44