32893
document
Rehabilitation of therapy-related cognitive deficits in patients after hematopoietic stem cell transplantation . Neuropsychological deficits are potential side effects of hematopoietic stem cell therapy ( HSCT ) . Systematic data on the long-term course of and therapeutic options for these consequences are limited . One hundred fifty-seven patients were screened for cognitive deficits following HSCT for malignant diseases at an in-patient oncologic rehabilitation clinic . Patients showing evidence of impairment were randomly assigned to one of two training groups : individualized PC-supported training or neuropsychological group therapy . The control group consisted of patients who received no specific training . During in-patient rehabilitation , the results of a comprehensive neuropsychological test battery improved significantly in all three groups , and no specific intervention effects were identified . Neuropsychological deficits were still evident in a subgroup of patients 6 months later . Correlation between neuropsychological testing and patients ' self-evaluation of cognitive functioning in daily life was generally low . Sustained attention and verbal-semantic memory played the main role for self-appraisal and in the designation as 'neuropsychologically impaired ' . In conclusion , a substantial number of patients revealed evidence of cognitive deficits a long time after HSCT . There is a need for more studies and for the development of differentiated rehabilitative measures for such therapeutic consequences .
32894
Intervention_Physical
Rehabilitation
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Intervention_Physical
hematopoietic stem cell therapy ( HSCT )
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Intervention_Surgical
.
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Intervention_Physical
HSCT
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Intervention_Psychological
individualized PC-supported training or neuropsychological group therapy .
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Intervention_Psychological
no specific training
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Intervention_Control
.
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Intervention_Physical
HSCT
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Intervention_Surgical
.
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Outcome_Mental
results of a comprehensive neuropsychological test battery
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Outcome_Mental
Neuropsychological deficits
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Outcome_Mental
Sustained attention
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Outcome_Mental
verbal-semantic memory
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Participant_Condition
patients after hematopoietic stem cell transplantation
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Participant_Sample-size
One hundred fifty-seven patients
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Participant_Condition
cognitive deficits following HSCT for malignant diseases
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Participant_Condition
impairment