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document
Midazolam as a main anesthesia induction agent -- a comparison with thiopental and diazepam . A clinical randomized investigation was undertaken to determine the value of midazolam as a narcotic adjuvant for anesthetic induction . Thirty ASA I-II adult patients undergoing selective surgery were allocated randomly into two groups to receive one of the following agents : midazolam 0.3 mg/kg , thiopental 5 mg/kg , or diazepam 0.4 mg/kg . The induction time as measured from the onset of injection to loss of the eyelash reflex was shortest in the case of thiopental ; while a lower frequency of apnea , lesser suppression of circulation , and lack of venous irritation were points favoring midazolam . However , further study is needed to clarify the moderate cardiovascular response seen during intubation in some cases as well as to elucidate any patient population differences .
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Intervention_Pharmacological
Midazolam
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Intervention_Pharmacological
thiopental and diazepam .
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Intervention_Pharmacological
midazolam
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Intervention_Pharmacological
midazolam 0.3 mg/kg , thiopental 5 mg/kg , or diazepam 0.4 mg/kg .
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Outcome_Other
value
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Outcome_Other
induction time as measured from the onset of injection to loss of the eyelash reflex
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Outcome_Physical
lower frequency of apnea , lesser suppression of circulation
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Outcome_Physical
lack of venous irritation
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Outcome_Physical
moderate cardiovascular response
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Participant_Sample-size
Thirty
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Participant_Condition
ASA I-II