8839
document
Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension : a pilot trial . OBJECTIVES We assessed the short-term antihypertensive effects of soluble fiber-rich whole oat cereals when added to a standard American diet . In addition , multiple assessments of insulin sensitivity were conducted . STUDY DESIGN This was a randomized , controlled , parallel-group pilot study designed to compare an oat cereal group ( standardized to 5.52 g/day beta-glucan ) to a low-fiber cereal control group ( less than 1.0 g/day total fiber ) over 6 weeks . POPULATION A total of 18 hypertensive and hyperinsulinemic ( = 10 U/mL or more ) men and women completed the trial . OUTCOMES MEASURED Primary study outcomes were changes in systolic blood pressure ( SBP ) and diastolic blood pressure ( DBP ) . Secondary outcomes included blood lipid , fasting glucose , and insulin levels and side effects related to elevated blood pressure and increased dietary fiber intake . RESULTS The oat cereal group experienced a 7.5 mm Hg reduction in SBP ( P & lt.01 ) and a 5.5 mm Hg reduction in DBP ( P & lt.02 ) , while there was virtually no change in either SBP or DBP in the control group . In the oat cereal group , a trend was observed for a lower total insulin response to a glucose load , suggesting improved insulin sensitivity . However , this could not be confirmed using estimates from the Bergman Minimal Model , perhaps because of our small sample size . The oats group experienced a significant reduction in both total cholesterol ( 9 % ) and low-density lipoprotein cholesterol ( 14 % ) . CONCLUSIONS The addition of oat cereals to the normal diet of patients with hypertension significantly reduces both SBP and DBP . Soluble fiber-rich whole oats may be an effective dietary therapy in the prevention and adjunct treatment of hypertension .
8840
Intervention_Other
Oat ingestion
8841
Intervention_Other
soluble fiber-rich whole oat cereals
8842
Intervention_Pharmacological
oat cereal group ( standardized to 5.52 g/day beta-glucan )
8843
Intervention_Pharmacological
a low-fiber cereal control group ( less than 1.0 g/day total fiber )
8844
Intervention_Pharmacological
oat cereals
8845
Intervention_Pharmacological
Soluble fiber-rich whole oats
8846
Outcome_Physical
systolic blood pressure ( SBP )
8847
Outcome_Physical
diastolic blood pressure ( DBP )
8848
Outcome_Physical
blood lipid
8849
Outcome_Physical
fasting glucose
8850
Outcome_Physical
insulin levels
8851
Outcome_Adverse-effects
side effects related to elevated blood pressure and increased dietary fiber intake
8852
Outcome_Physical
SBP
8853
Outcome_Physical
DBP
8854
Outcome_Physical
total insulin response
8855
Outcome_Physical
total cholesterol
8856
Outcome_Physical
low-density lipoprotein cholesterol
8857
Outcome_Physical
SBP
8858
Outcome_Physical
DBP
8859
Participant_Condition
patients with mild or borderline hypertension :