14319
document
Amphotericin versus pentamidine in antimony-unresponsive kala-azar . We compared the efficacy of amphotericin B and pentamidine isethionate in a prospective randomised trial in 120 uncomplicated and parasitologically confirmed cases of antimony-unresponsive kala-azar . Doses were twenty intramuscular injections of pentamidine 4 mg/kg on alternate days or fourteen definitive doses of amphotericin 0.5 mg/kg infused in 5 % dextrose on alternate days . 48 ( 80 % ) patients given pentamidine showed initial cure and 46 ( 77 % ) showed definitive cure compared with 60 ( 100 % ) and 59 ( 98 % ) cases , respectively , on amphotericin ( p < 0.001 ) . Amphotericin also brought about quicker abatement of fever and more complete spleen regression .
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Intervention_Pharmacological
Amphotericin
14321
Intervention_Pharmacological
pentamidine
14322
Intervention_Pharmacological
amphotericin B
14323
Intervention_Pharmacological
pentamidine isethionate
14324
Intervention_Pharmacological
pentamidine
14325
Intervention_Pharmacological
amphotericin
14326
Intervention_Pharmacological
pentamidine
14327
Intervention_Pharmacological
amphotericin
14328
Intervention_Pharmacological
Amphotericin
14329
Outcome_Other
initial cure
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Outcome_Other
definitive cure
14331
Outcome_Physical
abatement of fever
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Outcome_Adverse-effects
complete spleen regression
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Participant_Condition
antimony-unresponsive kala-azar
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Participant_Sample-size
120
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Participant_Condition
antimony-unresponsive kala-azar