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Menopausal quality of life : RCT of yoga , exercise , and omega-3 supplements . OBJECTIVE The purpose of this study was to determine the efficacy of 3 nonhormonal therapies for the improvement of menopause-related quality of life in women with vasomotor symptoms . STUDY DESIGN We conducted a 12-week 3 × 2 randomized , controlled , factorial design trial . Peri- and postmenopausal women , 40-62 years old , were assigned randomly to yoga ( n = 107 ) , exercise ( n = 106 ) , or usual activity ( n = 142 ) and also assigned randomly to a double-blind comparison of omega-3 ( n = 177 ) or placebo ( n = 178 ) capsules . We performed the following interventions : ( 1 ) weekly 90-minute yoga classes with daily at-home practice , ( 2 ) individualized facility-based aerobic exercise training 3 times/week , and ( 3 ) 0.615 g omega-3 supplement , 3 times/day . The outcomes were assessed with the following scores : Menopausal Quality of Life Questionnaire ( MENQOL ) total and domain ( vasomotor symptoms , psychosocial , physical and sexual ) . RESULTS Among 355 randomly assigned women who average age was 54.7 years , 338 women ( 95 % ) completed 12-week assessments . Mean baseline vasomotor symptoms frequency was 7.6/day , and the mean baseline total MENQOL score was 3.8 ( range , 1-8 from better to worse ) with no between-group differences . For yoga compared to usual activity , baseline to 12-week improvements were seen for MENQOL total -0.3 ( 95 % confidence interval , -0.6 to 0 ; P = .02 ) , vasomotor symptom domain ( P = .02 ) , and sexuality domain ( P = .03 ) scores . For women who underwent exercise and omega-3 therapy compared with control subjects , improvements in baseline to 12-week total MENQOL scores were not observed . Exercise showed benefit in the MENQOL physical domain score at 12 weeks ( P = .02 ) . CONCLUSION All women become menopausal , and many of them seek medical advice on ways to improve quality of life ; little evidence-based information exists . We found that , among healthy sedentary menopausal women , yoga appears to improve menopausal quality of life ; the clinical significance of our finding is uncertain because of the modest effect .
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Intervention_Physical
RCT of yoga
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Intervention_Physical
exercise
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Intervention_Pharmacological
omega-3 supplements
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Intervention_Pharmacological
nonhormonal therapies
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Intervention_Physical
yoga
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Intervention_Physical
exercise
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Intervention_Control
usual activity
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Intervention_Pharmacological
omega-3
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Intervention_Control
placebo
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Intervention_Pharmacological
omega-3 supplement
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Intervention_Physical
yoga
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Intervention_Physical
exercise
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Intervention_Pharmacological
omega-3 therapy
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Intervention_Physical
yoga
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Outcome_Physical
Menopausal quality of life :
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Outcome_Other
menopause-related quality of life
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Participant_Condition
menopause-related
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Participant_Condition
vasomotor symptoms