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document
Effect of secretin on children with autism : a randomized controlled trial . To determine the effect of intravenous porcine secretin on autistic behaviours in children aged 2 to 7 years , the effects of secretin on ( 1 ) performance on a standardized language measure , and ( 2 ) autistic behaviours , as rated by parents and child development professionals was examined . Employing a randomized , double-blind , placebo-controlled design , 95 participants were assigned to one of two groups and administered a single dose of either secretin or placebo . A follow-up assessment was conducted 3 weeks after the injection . No significant differences in language or autistic behaviour measures were observed at the 3-week follow-up between the groups . Also , there was no significant difference in the proportion of individuals who improved by > or = 6 points on the language measure at follow-up . This study showed no significant effects of secretin on children with autism . Our results are consistent with a systematic review of randomized controlled trials evaluating the effect of secretin in children with autism .
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Intervention_Pharmacological
secretin
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Intervention_Pharmacological
intravenous porcine secretin
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Intervention_Pharmacological
secretin
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Intervention_Control
placebo
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Outcome_Mental
language or autistic behaviour measures
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Outcome_Mental
> or = 6 points on the language measure
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Participant_Condition
children with autism
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Participant_Age
children aged 2 to 7 years
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Participant_Sample-size
95
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Participant_Condition
autism
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Participant_Condition
autism