12700
document
Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis ; 12-months results . The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25 % metronidazole dental gel as an adjunct to scaling and root planing ( SRP ) in the treatment of adult periodontitis . Eighty teeth in 18 patients were evaluated using a split mouth design . The test teeth received SRP and a 25 % metronidazole gel applied subgingivally on days 0 and 7 . The control teeth received SRP only . Clinical and microbiological examinations were carried out before treatment and on weeks 1 , 3 , 7 , 13 , 26 , 38 and 52 of the experimental period . Colony forming units of Porphyromonas gingivalis and Prevotella intermedia / Prevotella nigrescens were determined . Both treatments provided significant improvements in all the clinical and microbiological parameters ( P < 0.05 ) . However , none of the differences between the study groups were statistically significant ( P > 0.05 ) . As a conclusion , the present study does not provide evidence in favour of the routine use of adjunctive metronidazole dental gel in the treatment of adult periodontitis .
12701
Intervention_Pharmacological
metronidazole
12702
Intervention_Pharmacological
metronidazole dental gel
12703
Intervention_Physical
scaling and root planing ( SRP )
12704
Intervention_Physical
SRP
12705
Intervention_Pharmacological
metronidazole gel
12706
Intervention_Control
SRP only
12707
Outcome_Physical
clinical and microbiological parameters
12708
Outcome_Other
evidence in favour of the routine use of adjunctive metronidazole dental gel
12709
Outcome_Physical
adult periodontitis
12710
Participant_Condition
Eighty teeth in 18 patients
12711
Participant_Condition
adult periodontitis .