82504
document
Co-administration of pethidine and clonidine : a spinal anaesthetic technique for total hip replacement . Co-administration of pethidine 0.75 mg kg-1 and clonidine 75 micrograms intrathecally provided good intraoperative anaesthesia for total hip replacement , similar to that obtained using 0.5 % isobaric bupivacaine . Sensory and motor block were of shorter duration than that after 0.5 % isobaric bupivacaine and 0.5 % isobaric bupivacaine with morphine 0.5 mg ( P < 0.001 sensory block , P < 0.001 motor block ) . Postoperative morphine consumption , measured using a patient-controlled system , was similar to that in patients in the bupivacaine only group ( pethidine-clonidine : median 39 mg/24 h ; bupivacaine : median 34 mg/24 h ) but greater than that in the bupivacaine-morphine group ( median 8 mg/24 h ) ( P < 0.001 ) . Visual analogue pain scores after operation were similar to those with bupivacaine alone at all but one of the recording times but were greater than those in patients who received bupivacaine and morphine at 4 , 6 and 10 h after operation ( P < 0.001 , P < 0.04 , P < 0.02 ) . The combination did not offer any major advantage over conventional agents .
82505
Intervention_Pharmacological
pethidine
82506
Intervention_Pharmacological
clonidine
82507
Intervention_Surgical
total hip replacement
82508
Intervention_Pharmacological
pethidine 0.75 mg kg-1
82509
Intervention_Pharmacological
clonidine 75 micrograms
82510
Intervention_Surgical
total hip replacement
82511
Intervention_Pharmacological
0.5 % isobaric bupivacaine
82512
Intervention_Pharmacological
isobaric bupivacaine
82513
Intervention_Pharmacological
isobaric bupivacaine
82514
Intervention_Pharmacological
morphine
82515
Intervention_Pharmacological
morphine
82516
Intervention_Pharmacological
bupivacaine
82517
Intervention_Pharmacological
pethidine-clonidine
82518
Intervention_Pharmacological
bupivacaine
82519
Intervention_Pharmacological
bupivacaine-morphine
82520
Intervention_Pharmacological
bupivacaine alone
82521
Intervention_Pharmacological
bupivacaine
82522
Intervention_Pharmacological
morphine
82523
Outcome_Other
Postoperative
82524
Outcome_Physical
morphine consumption
82525
Outcome_Pain
Visual analogue pain scores