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document
Traumatic brain injury-related attention deficits : treatment outcomes with lisdexamfetamine dimesylate ( Vyvanse ) . BACKGROUND AND OBJECTIVES Attention deficits are often among the most persistent and debilitating impairments resulting from traumatic brain injury ( TBI ) . This study examined the effects of lisdexamfetamine dimesylate ( Vyvanse ) in treating attention deficits due to moderate-to-severe TBI . It was the first study of lisdexamfetamine dimesylate with this population and , in fact , was the first controlled trial in this area examining a stimulant medication option other than methylphenidate . METHODS This was a 12-week , randomized , double-blind , placebo-controlled , cross-over trial . A total of 22 rigorously selected cases were enrolled , 13 of whom completed the trial . They were 16-42 years of age and had newly acquired attention deficits persisting for 6-34 months post-injury . They were assessed on a broad range of neuropsychological and behavioural measures at baseline , 6-weeks and at 12-weeks . RESULTS AND CONCLUSIONS Positive treatment effects were found involving selective measures of sustained attention , working memory , response speed stability and endurance and in aspects of executive functioning . No major problems with safety or tolerability were observed . Some moderating treatment effects were found from a broad range of pre-treatment subject characteristics and injury variables examined . Avenues for further research and treatment applications in this area are discussed .
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Intervention_Pharmacological
lisdexamfetamine dimesylate ( Vyvanse ) .
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Intervention_Pharmacological
lisdexamfetamine dimesylate ( Vyvanse )
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Intervention_Pharmacological
lisdexamfetamine dimesylate
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Intervention_Pharmacological
methylphenidate .
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Intervention_Control
placebo-controlled
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Outcome_Mental
attention deficits :
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Outcome_Mental
attention deficits
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Outcome_Mental
attention deficits
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Outcome_Mental
neuropsychological and behavioural measures
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Outcome_Mental
sustained attention , working memory , response speed stability and endurance and in aspects of executive functioning .
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Outcome_Other
safety or tolerability
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Participant_Condition
Traumatic brain injury-related
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Participant_Condition
TBI
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Participant_Sample-size
22
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Participant_Sample-size
13
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Participant_Age
16-42 years of age
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Participant_Condition
attention deficits