50467
document
Enalapril and lisinopril in the treatment of mild to moderate essential hypertension . Hypertensive patients were randomly assigned to receive 5 mg of enalapril ( n = 50 ) or 10 mg of lisinopril ( n = 47 ) daily . During a four-week titration period , the doses were increased weekly to a maximum of 40 mg once daily until the treatment goal of diastolic blood pressure ( BP ) of less than 90 mmHg was reached ; treatment was then continued for four weeks . Systolic and diastolic BP declined significantly in the two treatment groups , from 147/98 mmHg in both the enalapril and lisinopril groups to 126/82 and 122/81 mmHg , respectively , at the end of treatment . During the first week of treatment , the goal of diastolic BP of less than 90 mmHg was reached by 40 % of the enalapril group and 62 % of the lisinopril group ; by the end of the titration period , 98 % and 96 % , respectively , had achieved the BP goal . Few side effects were reported and there were no abnormal laboratory findings during treatment . It is concluded that once-daily administration of enalapril or lisinopril was generally effective and well-tolerated in the management of mild to moderate uncomplicated essential hypertension .
50468
Intervention_Pharmacological
Enalapril
50469
Intervention_Pharmacological
lisinopril
50470
Intervention_Pharmacological
5 mg of enalapril
50471
Intervention_Pharmacological
10 mg of lisinopril
50472
Intervention_Pharmacological
enalapril
50473
Intervention_Pharmacological
lisinopril
50474
Intervention_Pharmacological
enalapril
50475
Intervention_Pharmacological
lisinopril
50476
Intervention_Pharmacological
enalapril
50477
Intervention_Pharmacological
lisinopril
50478
Outcome_Physical
Systolic and diastolic BP
50479
Outcome_Physical
diastolic BP
50480
Outcome_Physical
BP
50481
Outcome_Adverse-effects
side effects
50482
Participant_Condition
mild to moderate essential hypertension . Hypertensive patients
50483
Participant_Sample-size
two
50484
Participant_Condition
hypertension