9787
document
Efficacy of porcine secretin in children with autism and pervasive developmental disorder . Secretin , a gastrointestinal ( GI ) hormone , was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder ( PDD ) and chronic diarrhea . To determine the efficacy of secretin , we completed a double-blind , placebo-controlled , crossover ( 3 weeks ) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin . Children with chronic , active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo . Children with no GI problems are unaffected by either secretin or placebo . The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin .
9788
Intervention_Pharmacological
porcine secretin
9789
Intervention_Pharmacological
Secretin
9790
Intervention_Pharmacological
secretin
9791
Intervention_Control
placebo-controlled
9792
Intervention_Pharmacological
intravenous porcine secretin .
9793
Intervention_Pharmacological
secretin
9794
Intervention_Control
placebo .
9795
Intervention_Pharmacological
secretin
9796
Intervention_Control
placebo
9797
Intervention_Pharmacological
secretin
9798
Intervention_Pharmacological
secretin .
9799
Outcome_Other
Efficacy
9800
Outcome_Mental
language and behavior
9801
Outcome_Mental
aberrant behaviors