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document
Bronchoscopic findings in patients with a complete radiographic regression of small cell bronchogenic carcinoma . Fibre-optic bronchoscopy was performed in 21 patients with small cell bronchogenic carcinoma who demonstrated a complete radiographic regression of their chest lesions after 3-4 months of combination chemotherapy . Fifteen patients showed abnormalities at the site of the original tumour consisting of nodular elevations , narrowing of bronchi and/or fibrous strands or membranes . Microscopic evidence of residual cancer was obtained in 3 cases . In 3 out of 8 patients who underwent a further bronchoscopy after 18 months of treatment , disappearance of nodules was noted at the later examination . Persistent bronchial narrowing was observed in patients who became disease-free 2-yr survivors . It is concluded that tumour regression may be accompanied by scar formation , which complicate the interpretation of post-treatment abnormalities , and that further regression of intrabronchial lesions may occur beyond 3-4 months .
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Intervention_Physical
Fibre-optic bronchoscopy
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Intervention_Pharmacological
3-4 months of combination chemotherapy .
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Intervention_Surgical
bronchoscopy
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Outcome_Physical
Bronchoscopic
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Outcome_Physical
small cell bronchogenic carcinoma .
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Outcome_Physical
small cell bronchogenic carcinoma
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Outcome_Mental
abnormalities
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Outcome_Physical
site
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Outcome_Physical
tumour
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Outcome_Physical
nodular elevations , narrowing of bronchi and/or fibrous strands or membranes .
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Outcome_Physical
bronchoscopy
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Outcome_Physical
nodules
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Outcome_Physical
Persistent bronchial narrowing
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Outcome_Physical
scar formation
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Outcome_Physical
post-treatment abnormalities
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Participant_Condition
patients with a complete radiographic regression of small cell bronchogenic carcinoma .
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Participant_Sample-size
21