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document
Benefits of an oxygen reservoir cannula versus a conventional nasal cannula during exercise in hypoxemic COPD patients : a crossover trial . BACKGROUND The Oxymizer® is a special nasal cannula that provides a higher luminal diameter in combination with an incorporated oxygen ( O2 ) reservoir . It is assumed that a higher O2 concentration can be delivered breath by breath in order to increase oxygenation . OBJECTIVE We aimed to investigate the effects of the Oxymizer on endurance time in comparison to a conventional nasal cannula ( CNC ) . METHODS Forty-three patients with severe chronic obstructive pulmonary disease ( COPD , age 60 ± 9 years , FEV1 37 ± 16 % pred . ) and indications for LTOT were recruited during pulmonary rehabilitation for this cross-over study . After an initial maximal incremental cycle test , all patients performed 4 cycling endurance time tests at 70 % of their peak work rate ( twice with the Oxymizer and twice with a CNC , in reverse order ) . RESULTS The endurance time was significantly higher when patients cycled while using the Oxymizer in comparison to while using the CNC [ 858 ± 754 vs. 766 ± 652 s ; between-group difference 92 s ( 95 % confidence interval 32-152 ) , p < 0.001 ] . In addition to a longer cycling duration , O2 saturation at isotime was significantly higher with the Oxymizer ( 93.5 ± 5.4 vs. 90.4 ± 5.3 % ; p = 0.027 ) . Furthermore , there was a positive correlation ( r = 0.427 , p = 0.002 ) between the O2 flow rate and improvements in the constant work rate test , showing greater improvements in favor of the Oxymizer in patients with a higher demand for O2 ( ≥ 4 liters/min ) . CONCLUSION We show that O2 delivery via the Oxymizer is superior to a CNC with regard to endurance capacity and oxygenation during exercise in patients with severe COPD . It seems that patients with a higher demand for O2 ( ≥ 4 liters/min ) , in particular , may benefit more from the use of the Oxymizer .
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Intervention_Pharmacological
oxygen reservoir cannula
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Intervention_Pharmacological
conventional nasal cannula
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Outcome_Physical
endurance time
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Outcome_Physical
longer cycling duration
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Participant_Condition
hypoxemic COPD patients :
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Participant_Sample-size
Forty-three patients
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Participant_Condition
chronic obstructive pulmonary disease
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Participant_Age
age 60 ± 9 years