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document
Multicenter trial of cryotherapy for retinopathy of prematurity : preliminary results . Cryotherapy for Retinopathy of Prematurity Cooperative Group . We report the preliminary 3-month outcome of a multicenter randomized trial of cryotherapy for treatment of retinopathy of prematurity ( ROP ) . Transscleral cryotherapy to the avascular retina was applied to one randomly selected eye when there was threshold disease ( defined as five or more contiguous or eight cumulative 30 degree sectors [ clock hours ] of stage 3 ROP in zone 1 or 2 in the presence of " plus " disease ) . An unfavorable outcome was defined as posterior retinal detachment , retinal fold involving the macula , or retrolental tissue . At this writing , 172 infants had been examined 3 months after randomization . An unfavorable outcome was significantly less frequent in the eyes undergoing cryotherapy ( 21.8 % ) compared with the untreated eyes ( 43 % ) . While the surgery was stressful , no unexpected complications occurred during or following treatment . These data support the efficacy of cryotherapy in reducing by approximately one half the risk of unfavorable retinal outcome from threshold ROP .
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Intervention_Physical
cryotherapy
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Intervention_Physical
Cryotherapy
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Intervention_Physical
cryotherapy
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Intervention_Physical
Transscleral cryotherapy
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Intervention_Physical
cryotherapy
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Intervention_Physical
cryotherapy
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Outcome_Physical
posterior retinal detachment
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Outcome_Physical
retinal fold involving the macula
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Outcome_Physical
retrolental tissue
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Outcome_Adverse-effects
unexpected complications
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Outcome_Other
efficacy
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Participant_Condition
retinopathy of prematurity :