7903
document
Improved responsiveness of PCOS patients to clomiphene after CYP17a inhibitor . PURPOSE To study the effect of CYP17a inhibitor , " ketoconazole , " on clomiphene responsiveness in PCOS patients . METHODS Prospective analysis was employed with the setup at Alexandria IVF/ICSI center . Ninety-seven insulin-resistant PCOS patients undergoing ovulation induction using clomiphene citrate were randomly divided , by random number table , into two groups . The first group ( n = 49 ) received ketoconazole ( 400 mg daily ) till correction of metabolic syndrome followed by clomiphene ( 100 mg/day ) ; the second group ( n = 48 ) receiving clomiphene without ketoconazole pretreatment . Main outcome measures were incidence of clomiphene resistance , monofollicular response , fasting insulin/glucose ratio , serum testosterone , and pregnancy rates . RESULTS The ketoconazole group showed significantly ( p < 0.05 ) higher incidence of monofollicular response ( 38 % ) , higher pregnancy rates , and significantly less marked antiestrogenic manifestations than did the control group . They also had significantly lower incidence of clomiphene resistance ( 11.6 % ) , lower serum testosterone levels , less hyperinsulinaemia , than did the control group . CONCLUSION Ketoconazole improved clomiphene responsivenss in PCOS patients and attenuated its untoward biological effects .
7904
Intervention_Pharmacological
clomiphene
7905
Intervention_Pharmacological
CYP17a inhibitor .
7906
Intervention_Pharmacological
CYP17a inhibitor , " ketoconazole , "
7907
Intervention_Pharmacological
clomiphene citrate
7908
Intervention_Pharmacological
ketoconazole
7909
Intervention_Pharmacological
clomiphene
7910
Intervention_Pharmacological
clomiphene
7911
Intervention_Pharmacological
ketoconazole pretreatment
7912
Intervention_Pharmacological
ketoconazole
7913
Intervention_Pharmacological
Ketoconazole
7914
Outcome_Physical
incidence of clomiphene resistance , monofollicular response , fasting insulin/glucose ratio , serum testosterone , and pregnancy rates .
7915
Outcome_Physical
incidence of monofollicular response
7916
Outcome_Physical
higher pregnancy rates
7917
Outcome_Physical
significantly less marked antiestrogenic manifestations
7918
Outcome_Physical
incidence of clomiphene resistance
7919
Outcome_Physical
lower serum testosterone levels
7920
Outcome_Physical
hyperinsulinaemia
7921
Outcome_Physical
clomiphene responsivenss in PCOS patients
7922
Outcome_Physical
untoward biological effects .
7923
Participant_Condition
PCOS patients