75543
document
Effects of maternal glucose infusion on fetal acid-base status in human pregnancy . The maternal and fetal metabolic effects of three commonly used intravenous fluids administered before regional anesthesia were studied in 32 gravid women undergoing elective cesarean section at term . Patients were randomized into one of three groups to receive 1 L of either 5 % dextrose ( 50 gm of glucose ) or Ringer 's lactate or isotonic saline solution before epidural anesthesia . Acute glucose infusion resulted in maternal hyperglycemia , hyperinsulinemia , and an increase in the blood lactate level . Cord blood glucose , insulin , and lactate levels were also increased in this group . The key finding of this study was the significant lowering of pH in the umbilical cord vein ( 7.31 +/- 0.04 ) and artery ( 7.21 +/- 0.06 ) in the glucose-infused group when compared with the non-glucose infusion groups ( p less than 0.05 ) . Confounding perinatal factors such as maternal position , maternal hypotension , and prolonged time of surgery did not influence the fetal acid-base status . Thus acute maternal glucose infusion in normal patients can cause fetal hyperglycemia , metabolic acidosis , and neonatal hypoglycemia . These findings may be of particular clinical importance when fetal distress or fetal hypoxemia is due to other perinatal events . Under these circumstances , acute maternal glucose infusion may further contribute to fetal metabolic acidosis .
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Intervention_Pharmacological
maternal glucose infusion
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Intervention_Pharmacological
5 % dextrose
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Intervention_Pharmacological
glucose
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Intervention_Pharmacological
Ringer 's lactate
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Intervention_Pharmacological
isotonic saline solution
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Intervention_Physical
epidural anesthesia
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Outcome_Other
Acute glucose infusion
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Outcome_Adverse-effects
maternal hyperglycemia
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Outcome_Physical
hyperinsulinemia
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Outcome_Physical
increase in the blood lactate level
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Outcome_Physical
significant lowering of pH in the umbilical cord vein
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Outcome_Physical
artery
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Outcome_Other
non-glucose infusion
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Outcome_Physical
maternal position
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Outcome_Physical
maternal hypotension
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Outcome_Other
prolonged time of surgery
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Outcome_Other
maternal glucose infusion
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Outcome_Physical
fetal hyperglycemia
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Outcome_Physical
metabolic acidosis
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Outcome_Physical
neonatal hypoglycemia
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Outcome_Physical
fetal distress
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Outcome_Physical
fetal hypoxemia
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Outcome_Other
acute maternal glucose infusion
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Outcome_Physical
fetal metabolic acidosis
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Participant_Condition
pregnancy
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Participant_Sample-size
32
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Participant_Condition
gravid
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Participant_Sex
women
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Participant_Condition
elective cesarean section