78936
document
Effect of oral diuretics on pulmonary mechanics in infants with chronic bronchopulmonary dysplasia : results of a double-blind crossover sequential trial . In a randomized double-blind crossover trial with sequential analysis , the effects of oral diuretics were compared with the effects of placebo on pulmonary mechanics in ten infants with bronchopulmonary dysplasia ( BPD ) . Pulmonary mechanics were measured before and at the end of a week of treatment with oral diuretics ( chlorothiazide , 20 mg/kg/dose and spironolactone , 1.5 mg/kg/dose ) given twice daily , or placebo . Mean airway resistance decreased 35.3 cm H2O/L/s , mean specific airway conductance increased 0.095 1/L/s/cm H2O , and mean dynamic pulmonary compliance increased 1.74 mL/cm H2O during treatment with diuretics ( all P less than .001 ) , but not during treatment with placebo . The infants ' rate of weight gain decreased on the first three days of diuretic treatment , but was thereafter comparable with weight gain during treatment with placebo . Fluid intake was similar in infants receiving diuretics and placebo . But , infants receiving diuretics not only had significantly increased urine output , osmolal clearance , and potassium and phosphorus excretion , but these infants also retained less fluid , and , in addition , excreted less calcium than infants receiving placebo . It is concluded that oral diuretics improve lung function in infants with chronic bronchopulmonary dysplasia ; however , potassium and phosphorus depletion are potential complications of treatment .
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Intervention_Pharmacological
diuretics
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Intervention_Pharmacological
diuretics
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Intervention_Control
placebo
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Intervention_Pharmacological
oral diuretics
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Intervention_Pharmacological
chlorothiazide , 20 mg/kg/dose
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Intervention_Pharmacological
spironolactone , 1.5 mg/kg/dose )
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Intervention_Control
placebo
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Intervention_Control
placebo
78945
Intervention_Control
placebo
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Intervention_Pharmacological
diuretics
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Outcome_Mental
Mean airway resistance
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Outcome_Mental
specific airway conductance
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Outcome_Mental
mean dynamic pulmonary compliance
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Outcome_Physical
weight gain
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Outcome_Mental
weight gain
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Outcome_Physical
Fluid intake
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Outcome_Mental
urine output
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Outcome_Mental
osmolal clearance
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Outcome_Physical
potassium and phosphorus excretion
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Outcome_Mental
retained less fluid
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Outcome_Physical
excreted less calcium
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Outcome_Physical
lung function
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Participant_Condition
infants with chronic bronchopulmonary dysplasia :
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Participant_Condition
double-blind crossover sequential trial .