84720
document
A double-blind comparison of oral ketoprofen 'controlled release ' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening . A double-blind , double-dummy , crossover study was carried out in 8 centres to compare the efficacy and tolerability of 'controlled-release ' ketoprofen tablets ( 200 mg ) with that of indomethacin suppositories ( 100 mg ) in out-patients with definite or classical rheumatoid arthritis . Patients were allocated at random to receive a daily bedtime dose of either 1 ketoprofen tablet or 1 indomethacin suppository plus the dummy of the other formulation for a period of 3 weeks . They were then crossed over to the alternative treatment for a further 3 weeks . Daily diary records were kept by patients of the number of night-time awakenings due to pain , pain severity at awakening in the morning and the duration of early morning stiffness . Treatment efficacy was also assessed at the end of each trial period by means of an articular index and by physician 's and patient 's overall evaluation of response . Adverse effects spontaneously mentioned by the patients or elicited by direct questioning using a symptom check-list were recorded . Statistical analysis of the results from 83 evaluable patients showed that the 'controlled-release ' tablet formulation of 200 mg ketoprofen was equally as effective as the 100 mg indomethacin suppository in the treatment of rheumatoid arthritis , especially with regard to pain at awakening and morning stiffness . Side-effects in both groups were those commonly seen with non-steroidal anti-inflammatory drugs and , as expected , gastro-intestinal and CNS disturbances predominated . Overall , side-effects were fewer with ketoprofen than with indomethacin .
84721
Intervention_Pharmacological
oral ketoprofen 'controlled release
84722
Intervention_Pharmacological
indomethacin suppository
84723
Intervention_Pharmacological
'controlled-release ' ketoprofen tablets
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Intervention_Pharmacological
indomethacin suppositories
84725
Intervention_Pharmacological
ketoprofen
84726
Intervention_Pharmacological
indomethacin suppository
84727
Intervention_Pharmacological
ketoprofen
84728
Intervention_Pharmacological
indomethacin suppository
84729
Intervention_Pharmacological
ketoprofen
84730
Intervention_Pharmacological
indomethacin
84731
Outcome_Other
'controlled-release ' tablet formulation of 200 mg
84732
Outcome_Other
indomethacin suppository
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Outcome_Pain
pain at awakening and morning stiffness
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Outcome_Adverse-effects
gastro-intestinal and CNS disturbances
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Outcome_Adverse-effects
side-effects
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Outcome_Other
ketoprofen
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Outcome_Other
indomethacin
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Participant_Condition
out-patients with definite or classical rheumatoid arthritis .