74786
document
Effects of misoprostol on human circulation . Prostaglandins ( PGs ) of the E-type are potent vasodilators in most species and in most vascular beds . However , vasoconstrictor effects of PGEs have also been noted at selected sites . This study examined the effects of misoprostol , a PGE1 analog with antiulcer activity , on the human cardiovascular system . Twenty healthy subjects participated in this double-blind , placebo-controlled , parallel group study . Following a 12 hour fast , heart rate , arterial blood pressure , light reflex plethysmography of the finger , resting blood flow volume in the lower arm and leg and peripheral vascular resistance were measured at 10 min . intervals for 1 hour prior to drug administration , to permit calculating baseline values . Misoprostol ( 400 mcg ) or its matching placebo were administered orally , and the measurements were repeated at 10 min . intervals over the next 2 hours . A decrease in leg blood flow volume and a corresponding increase in leg peripheral vascular resistance were noted in the misoprostol group . A statistically significant decrease in heart rate between the two treatment groups was also noted . These small changes were not considered to be of clinical importance . No adverse experiences were reported . In conclusion , a single dose of misoprostol ( 400 mcg ) has no clinically significant vasoconstrictive or vasodilative properties in man .
74787
Intervention_Pharmacological
misoprostol
74788
Intervention_Pharmacological
misoprostol
74789
Intervention_Pharmacological
Misoprostol
74790
Intervention_Control
placebo
74791
Intervention_Pharmacological
misoprostol
74792
Intervention_Pharmacological
misoprostol
74793
Outcome_Physical
misoprostol
74794
Outcome_Physical
misoprostol
74795
Outcome_Physical
peripheral vascular resistance
74796
Outcome_Physical
leg blood flow volume
74797
Outcome_Physical
corresponding increase in leg peripheral vascular resistance
74798
Outcome_Physical
heart rate
74799
Outcome_Physical
adverse experiences
74800
Outcome_Physical
vasoconstrictive or vasodilative
74801
Participant_Condition
human circulation
74802
Participant_Sample-size
Twenty