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document
Prophylaxis with meropenem of septic complications in acute pancreatitis : a randomized , controlled trial versus imipenem . OBJECTIVES Prophylactic antibiotics are helpful in decreasing the incidence of septic complications in acute pancreatitis . The aim of this study was to compare the efficacy of meropenem , a new carbapenem antibiotic , with that of imipenem , which is the standard prophylactic treatment in patients with severe acute pancreatitis . METHODS One hundred seventy-six patients with necrotizing pancreatitis were prospectively randomized to prophylactic treatment with 0.5 g meropenem t.i.d . intravenously or 0.5 g imipenem q.i.d . intravenously . The occurrence of infection of pancreatic necrosis , rate of extrapancreatic infections , systemic and local complications , need for surgery , mortality rate , and length of hospitalization were recorded for each group . When a septic complication of pancreatic necrosis was suspected , fine needle aspiration with cultures of the sample was performed . Surgery was performed in cases of verified infected necrosis . CONCLUSION No difference was observed between patients treated with meropenem and those treated with imipenem in terms of incidence of pancreatic infection ( 11.4 % versus 13.6 % ) and extrapancreatic infections ( 21.6 % versus 23.9 % ) and clinical outcome . Meropenem is as effective as imipenem in preventing septic complications of patients with severe acute pancreatitis .
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Intervention_Pharmacological
meropenem
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Intervention_Pharmacological
imipenem
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Intervention_Pharmacological
meropenem
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Intervention_Pharmacological
new carbapenem antibiotic
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Intervention_Pharmacological
imipenem
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Intervention_Control
prophylactic treatment
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Intervention_Control
prophylactic treatment
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Intervention_Pharmacological
0.5 g meropenem t.i.d
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Intervention_Pharmacological
imipenem
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Intervention_Pharmacological
meropenem
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Intervention_Pharmacological
imipenem
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Intervention_Pharmacological
Meropenem
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Intervention_Pharmacological
imipenem
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Outcome_Physical
septic complications
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Outcome_Physical
septic complications
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Outcome_Physical
occurrence of infection of pancreatic necrosis
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Outcome_Physical
rate of extrapancreatic infections
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Outcome_Adverse-effects
systemic and local complications
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Outcome_Other
need for surgery
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Outcome_Mortality
mortality rate
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Outcome_Other
length of hospitalization
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Outcome_Physical
septic complication
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Outcome_Physical
incidence of pancreatic infection
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Outcome_Physical
extrapancreatic infections
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Outcome_Physical
clinical outcome
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Outcome_Physical
septic complications
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Participant_Condition
severe acute pancreatitis
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Participant_Sample-size
One hundred seventy-six
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Participant_Condition
necrotizing pancreatitis