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document
Minocycline safety and tolerability in Huntington disease . Minocycline is an antibiotic with anti-inflammatory and antiapoptotic properties that prolongs survival in a transgenic Huntington disease ( HD ) mouse model . In a double-blind , randomized , placebo-controlled study of minocycline in 60 HD patients , the authors determined that over 8 weeks , minocycline at 100 and 200 mg/day was well tolerated and safe in HD patients . Tolerability and adverse event frequency were similar between treatment and placebo groups .
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Intervention_Pharmacological
Minocycline
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Intervention_Pharmacological
Minocycline
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
minocycline
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Intervention_Pharmacological
minocycline at 100 and 200 mg/day
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Outcome_Other
safety and tolerability
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Outcome_Other
well tolerated and safe
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Outcome_Other
Tolerability
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Outcome_Adverse-effects
adverse event frequency
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Participant_Condition
Huntington disease
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Participant_Condition
Huntington disease
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Participant_Condition
HD
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Participant_Sample-size
60
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Participant_Condition
HD
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Participant_Condition
HD