21943
document
Association between platelet activation and fibrinolysis in acute stroke patients . We aimed to evaluate platelet activation and fibrinolyis in acute atherosclerotic ischemic stroke patients to clarify the relationship between them . Plasma P-selectin antigen , tissue plasminogen activator ( tPA ) antigen and activity , and plasminogen activator inhibitor-1 ( PAI-1 ) activity were determined in 60 acute atherosclerotic stroke patients and matched control subjects . All patients were examined within 72 h after stroke onset . The levels of P-selectin , tPA antigen , and PAI-1 activity were all significantly higher in stroke patients compared with controls ( all p < 0.0001 ) ; the level of tPA activity was significantly lower in patients than that in controls ( p < 0.0001 ) . These markers did not change much at different time points within 72 h. In stroke group , P-selectin concentration was highly correlated to PAI-1 activity ( r = 0.8433 , p < 0.001 ) , but not to tPA antigen ( r = -0.1752 , p > 0.05 ) , and tPA activity ( r = 0.2465 , p > 0.05 ) , which was further confirmed in the multiple linear regression analysis ( F = 47.052 , p < 0.0001 ) . Our results indicate increased platelet activation and decreased fibrinolysis in patients with acute atherosclerotic ischemic stroke . Increased platelet activation may be correlated with decreased fibrinolysis .
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Intervention_Pharmacological
Plasma P-selectin antigen
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Intervention_Pharmacological
tissue plasminogen activator ( tPA ) antigen
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Intervention_Pharmacological
plasminogen activator inhibitor-1 ( PAI-1 ) activity
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Intervention_Physical
P-selectin , tPA antigen
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Intervention_Physical
PAI-1
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Intervention_Physical
P-selectin
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Intervention_Pharmacological
tPA
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Intervention_Pharmacological
tPA
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Outcome_Physical
Plasma P-selectin antigen
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Outcome_Physical
tissue plasminogen activator ( tPA ) antigen and activity
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Outcome_Physical
plasminogen activator inhibitor-1 ( PAI-1 ) activity
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Outcome_Physical
levels of P-selectin , tPA antigen
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Outcome_Physical
PAI-1 activity
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Outcome_Physical
significantly higher
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Outcome_Physical
level of tPA activity
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Outcome_Physical
P-selectin concentration
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Outcome_Physical
PAI-1 activity
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Outcome_Physical
tPA antigen
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Outcome_Physical
tPA activity
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Outcome_Physical
increased platelet activation
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Outcome_Physical
decreased fibrinolysis
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Outcome_Physical
platelet activation
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Participant_Condition
acute stroke
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Participant_Condition
acute atherosclerotic ischemic stroke
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Participant_Sample-size
60
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Participant_Condition
stroke
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Participant_Condition
stroke
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Participant_Condition
stroke