83046
document
Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer 's disease . Cortisol levels in patients with Alzheimer 's disease ( AD ) are relatively unaffected by a challenge with dexamethasone ( DEX ) in vivo . The present study demonstrates that DEX is less inhibitory for phytohemagglutinin ( PHA ) -induced T cell proliferation in AD patients as compared to age-matched controls . Since no significant differences were found between AD patients and age-matched controls with regard to the fraction of CD45RA+ or CD45RO+ CD4+ T cells nor the ability of peripheral blood mononuclear cells to produce IL-2 or IL-4 , it is unlikely that the difference in DEX sensitivity is due to a changed lymphokine profile or a changed composition of the CD4+ T cell population . Sensitivity to DEX was negatively correlated with the ability to produce IL-2 and IL-4 in the controls but not in AD patients . This suggests that IL-2 and IL-4 synthesis in AD patients is less sensitive to regulation by glucocorticoids .
83047
Intervention_Pharmacological
dexamethasone
83048
Intervention_Pharmacological
dexamethasone
83049
Intervention_Pharmacological
DEX
83050
Intervention_Pharmacological
DEX
83051
Intervention_Pharmacological
DEX
83052
Intervention_Pharmacological
glucocorticoids
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Outcome_Physical
Decreased sensitivity to dexamethasone
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Outcome_Physical
Cortisol levels
83055
Outcome_Physical
less inhibitory for phytohemagglutinin ( PHA ) -induced T cell proliferation in AD patients
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Outcome_Physical
fraction of CD45RA+ or CD45RO+ CD4+ T cells
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Outcome_Physical
ability of peripheral blood mononuclear cells to produce IL-2 or IL-4
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Outcome_Physical
ability to produce IL-2 and IL-4
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Outcome_Physical
IL-2 and IL-4 synthesis in AD patients
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Participant_Condition
patients with Alzheimer 's disease .