44344
document
Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis in surgery . A total of 108 volunteers undergoing an elective surgical procedure were randomly given a single 2-g intravenous prophylactic dose of either a cephalosporin or mezlocillin . Stool samples were cultured for Clostridium difficile the day before the operation and later on postoperative days 4 , 7 , and 14 . C. difficile was detected in 23.0 % of patients who received a cephalosporin ( cefoxitin , 8.3 % ; cefazolin , 14.3 % ; cefotetan , 20.0 % ; ceftriaxone , 25.0 % ; cefoperazone , 43.7 % ) , in 3.3 % of patients given mezlocillin , and in none of 15 control volunteers given no antimicrobial agent . No patient experienced diarrhea .
44345
Intervention_Pharmacological
single-dose antibiotic prophylaxis
44346
Intervention_Pharmacological
intravenous prophylactic dose of either a cephalosporin or mezlocillin .
44347
Intervention_Pharmacological
cephalosporin ( cefoxitin , 8.3 % ; cefazolin , 14.3 % ; cefotetan , 20.0 % ; ceftriaxone , 25.0 % ; cefoperazone , 43.7 % )
44348
Intervention_Pharmacological
mezlocillin
44349
Intervention_Control
no antimicrobial agent .
44350
Outcome_Physical
Clostridium difficile
44351
Outcome_Physical
C. difficile
44352
Outcome_Adverse-effects
diarrhea .
44353
Participant_Sample-size
108
44354
Participant_Condition
elective surgical procedure
44355
Participant_Sample-size
15