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document
Effects of digoxin on muscle reflexes in normal humans . Blockade of the skeletal muscle Na ( + ) -K ( + ) -ATPase pump by digoxin could result in a more marked hyperkaliema during a forearm exercise , which in turn could stimulate the mechano- and metaboreceptors . In a randomized , double-blinded , placebo-controlled , and cross-over-design study , we measured mean blood pressure ( MBP ) , heart rate ( HR ) , ventilation ( V ( E ) ) , oxygen saturation ( SpO ( 2 ) ) , muscle sympathetic nerve activity ( MSNA ) , venous plasma potassium and lactic acid during dynamic handgrip exercises , and local circulatory arrest in 11 healthy subjects . Digoxin enhanced MBP during exercise but not during the post-handgrip ischemia and had no effect on HR , V ( E ) , SpO ( 2 ) , and MSNA . Venous plasma potassium and lactic acid were also not affected by digoxin-induced skeletal muscle Na ( + ) -K ( + ) -ATPase blockade . We conclude that digoxin increased MBP during dynamic exercise in healthy humans , independently of changes in potassium and lactic acid . A modest direct sensitization of the muscle mechanoreceptors is unlikely and other mechanisms , independent of muscle reflexes and related to the inotropic effects of digoxin , might be implicated .
41730
Intervention_Pharmacological
digoxin
41731
Intervention_Pharmacological
digoxin
41732
Intervention_Pharmacological
Digoxin
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Intervention_Pharmacological
digoxin-induced
41734
Intervention_Pharmacological
digoxin
41735
Intervention_Pharmacological
digoxin
41736
Participant_Sample-size
11 healthy subjects
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Participant_Condition
healthy humans