74582
document
Effects of mecamylamine on human cigarette smoking and subjective ratings . Multiple measures of cigarette smoking , subjective effect and physiological effect were collected during 90-min test sessions in normal volunteers . Before sessions subjects received oral doses of mecamylamine ( 2.5 , 5.0 , 10 , 20 mg ) or placebo . Each dose and placebo was given three times in a randomized block sequence . Mecamylamine increased several measures of cigarette smoking , including number of cigarettes , number of puffs per cigarette , and expired air carbon monoxide level . Mecamylamine also produced modest , dose-related decreases in standing blood pressure and increases in standing heart rate . The subjective effects produced by mecamylamine were not characteristic of those of psychoactive drugs . Mecamylamine appears to have increased cigarette smoking by decreasing the effective dose level of nicotine available from cigarette smoking .
74583
Intervention_Pharmacological
mecamylamine
74584
Intervention_Pharmacological
oral doses of mecamylamine ( 2.5 , 5.0 , 10 , 20 mg ) or placebo
74585
Intervention_Pharmacological
placebo
74586
Intervention_Pharmacological
Mecamylamine
74587
Intervention_Pharmacological
Mecamylamine
74588
Intervention_Pharmacological
mecamylamine
74589
Intervention_Pharmacological
Mecamylamine
74590
Outcome_Physical
number of cigarettes
74591
Outcome_Physical
number of puffs per cigarette
74592
Outcome_Physical
expired air carbon monoxide level
74593
Outcome_Physical
blood pressure
74594
Outcome_Physical
standing heart rate
74595
Participant_Condition
cigarette smoking
74596
Participant_Condition
normal