83522
document
A comparison of lisinopril and nifedipine in the treatment of mild to moderate hypertension . A multicentre study . Lisinopril has been compared with slow-release nifedipine in a 16-week double-blind , randomized , parallel-group study involving 102 patients with mild to moderate hypertension . Sitting systolic and diastolic blood pressures were reduced 6 and 5 mmHg more by lisinopril than by nifedipine over 12 weeks monotherapy . After 12 weeks a greater proportion of patients taking lisinopril was controlled ( sitting diastolic blood pressure below 95 mm Hg ) than in those taking nifedipine . As a result , 17 % of those taking lisinopril and 38 % of those taking nifedipine required additional therapy with hydrochlorothiazide . The addition of hydrochlorothiazide resulted in similar response rates in the lisinopril and nifedipine groups ( 89 % and 75 % respectively ) . The rate of reporting of adverse events considered to be drug-related and the rate of withdrawals were similar for both treatments . Cough was more often reported with lisinopril and headache , sweating , and hot flushes with nifedipine . We conclude that once-daily titrated doses of lisinopril produced better control of blood pressure than twice-daily titrated doses of nifedipine .
83523
Intervention_Pharmacological
lisinopril and nifedipine
83524
Intervention_Pharmacological
Lisinopril
83525
Intervention_Pharmacological
nifedipine
83526
Intervention_Pharmacological
lisinopril
83527
Intervention_Pharmacological
nifedipine
83528
Intervention_Pharmacological
lisinopril
83529
Intervention_Pharmacological
nifedipine .
83530
Intervention_Pharmacological
lisinopril
83531
Intervention_Pharmacological
nifedipine
83532
Intervention_Pharmacological
hydrochlorothiazide
83533
Intervention_Pharmacological
lisinopril
83534
Intervention_Pharmacological
nifedipine
83535
Intervention_Pharmacological
lisinopril
83536
Intervention_Pharmacological
nifedipine .
83537
Intervention_Pharmacological
lisinopril
83538
Intervention_Pharmacological
nifedipine .
83539
Outcome_Physical
Sitting systolic and diastolic blood pressures
83540
Outcome_Physical
hydrochlorothiazide
83541
Outcome_Adverse-effects
adverse events
83542
Outcome_Adverse-effects
Cough
83543
Outcome_Adverse-effects
headache , sweating
83544
Outcome_Adverse-effects
hot flushes
83545
Outcome_Physical
blood pressure
83546
Participant_Condition
mild to moderate hypertension
83547
Participant_Sample-size
102