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document
Anti-IgG antibodies during immunotherapy with purified grass pollen extracts . In a double blind study 40 patients were allocated specific immunotherapy ( hyposensitization ) with partially purified timothy extract or two timothy major allergens 19 , 25 . All patients had typical grass pollen hay fever , in 27 % associated with grass pollen asthma and in 13 % with birch pollen allergy . Serum IgG anti-IgG antibodies were determined after dithiothreitol treatment . Before hyposensitization , IgG anti-IgG titres greater than or equal to 9 were demonstrated in 45 % of the patients . During hyposensitization IgG anti-IgG titres showed a slight initial increase followed by a decrease below pretreatment level . Neither increase nor decrease was statistically significant . Reactions to rabbit IgG F ( ab ' ) 2 fractions were only obtained during hyposensitization . The occurrence of anti-IgG antibodies did no correlate with symptoms , side effects , or the level of allergen-specific IgG . In a previous study it was demonstrated that patients with multiallergy hyposensitized with combined allergen extracts showed a statistically significant increase in IgG anti-IgG titres during treatment . The increase failed to appear in the present patients allergic only to pollen and treated with purified allergen extracts . It is therefore suggested that a multiallergic condition and the combination and/or purification of allergen extracts administered during hyposensitization may influence the production of IgG anti- IgG antibodies .
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Intervention_Pharmacological
specific immunotherapy ( hyposensitization )
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Intervention_Pharmacological
partially purified timothy extract
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Intervention_Pharmacological
two timothy major allergens 19 , 25
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Outcome_Physical
Serum IgG anti-IgG antibodies
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Outcome_Physical
IgG anti-IgG titres
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Outcome_Physical
IgG anti-IgG titres
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Outcome_Physical
Reactions to rabbit IgG F ( ab ' ) 2
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Outcome_Physical
anti-IgG antibodies
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Outcome_Physical
symptoms
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Outcome_Adverse-effects
side effects ,
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Outcome_Physical
the level of allergen-specific IgG
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Outcome_Physical
IgG anti-IgG titres
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Outcome_Physical
IgG anti- IgG antibodies