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document
Mecamylamine reduces some EEG effects of nicotine chewing gum in humans . Spontaneous EEG was recorded in nine cigarette smokers who had been abstinent from tobacco for 12 hr . Subjects were treated with a capsule containing either centrally acting nicotine blocker , mecamylamine ( 10 mg ) , or placebo . At each of three 60-min intervals after the capsule was ingested , the subjects chewed two pieces of gum containing a total of 0 , 4 or 8 mg of nicotine . Nicotine and mecamylamine dose combinations were randomized across subjects . Two three-minute periods of spontaneous EEG were recorded before the capsule and before and after gum chewing from bipolar electrode montages at the following positions : Cz-T5 , Cz-T6 , Cz-F7 and Cz-F8 . During one period the subjects relaxed with eyes closed , in the other period they performed a math task with eyes open . When the drugs were given individually , mecamylamine decreased beta power and nicotine gum ( 4 and 8 mg ) increased alpha frequency . Mecamylamine pretreatment prevented the increase in alpha frequency caused by the 4 mg gum dose but not the 8 mg dose . Alpha power was increased by the 8 mg gum dose and that increase was prevented by mecamylamine . Self-reported ratings of the " strength " of the gum were significantly diminished by mecamylamine pretreatment . The data are consistent with the results of earlier studies which indicate that the effects of tobacco administration and withdrawal are mediated by central actions of nicotine .
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Intervention_Pharmacological
Mecamylamine
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Intervention_Pharmacological
centrally acting nicotine blocker , mecamylamine
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Intervention_Control
or placebo .
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Intervention_Pharmacological
Nicotine and mecamylamine
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Intervention_Pharmacological
mecamylamine
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Intervention_Pharmacological
Mecamylamine
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Intervention_Pharmacological
mecamylamine .
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Outcome_Physical
beta power
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Outcome_Physical
alpha frequency .
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Outcome_Physical
alpha frequency
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Outcome_Other
Alpha power
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Outcome_Physical
" strength "
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Participant_Sample-size
nine
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Participant_Condition
cigarette smokers