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document
Chemotherapy of advanced gastric carcinoma ( stage IV ) : a randomized study of FAM versus 5-FU plus BCNU . Forty-six patients with advanced gastric carcinoma ( Stage IV ) were evaluated in a prospective randomized comparison of two chemotherapy regimens ( FAM versus 5-FU plus BCNU ) to identify therapeutic activity . Treatment groups were well balanced with respect to known prognostic factors . Thirty-three patients had measurable disease and thirteen had only microscopic residual disease in the resection margins . The overall median survival of the entire group was 13.2 months . Two ( 6 % ) patients with measurable disease reached complete response ( CR ) , 1 ( 3 % ) partial response ( PR ) , 12 ( 36 % ) had stable disease ( SD ) and 18 ( 56 % ) had progressive disease ( PD ) . The responders had not reached the median survival yet , the patients with SD had a median survival of 14.7 months and the PD 9.5 months . In the FAM arm there were 3 ( 18 % ) responders ( 2 CR and 1 PR ) , 7 ( 41 % ) SD and 7 ( 41 % ) PD , versus O responders , 5 ( 31 % ) SD and 11 ( 69 % ) PD in the 5-FU plus BCNU arm . In the FAM arm the median survival was 15.7 months versus 9.9 months in the other therapeutic arm . The statistical analysis indicated that survival associated with FAM regimen was superior to that reached with the 5-FU plus BCNU regimen . Thirteen patients with unmeasurable disease had a median survival of 15.9 months .
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Intervention_Pharmacological
FAM
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Intervention_Pharmacological
5-FU plus BCNU
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Intervention_Pharmacological
chemotherapy
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Intervention_Pharmacological
FAM
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Intervention_Pharmacological
5-FU plus BCNU
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Intervention_Pharmacological
FAM
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Intervention_Pharmacological
FAM
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Intervention_Pharmacological
FAM
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Intervention_Pharmacological
5-FU plus BCNU
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Outcome_Mortality
overall median survival
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Outcome_Other
complete response ( CR )
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Outcome_Other
partial response ( PR )
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Outcome_Other
stable disease ( SD )
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Outcome_Other
progressive disease ( PD )
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Outcome_Mortality
median survival
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Outcome_Mortality
survival
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Outcome_Mortality
median survival
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Outcome_Mortality
survival
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Participant_Condition
advanced gastric carcinoma ( stage IV ) :
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Participant_Condition
Forty-six patients with advanced gastric carcinoma ( Stage IV ) were evaluated
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Participant_Sample-size
Thirty-three
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Participant_Sample-size
thirteen
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Participant_Sample-size
Thirteen