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Indicators for Cervical Length in Twin Pregnancies . OBJECTIVE Cervical length ( CL ) is associated with the risk of preterm birth ( PTB ) in multiple pregnancies . However , the position of CL within the pathophysiological pathway of PTB is unclear , and it is unknown which factors are predictive for CL . This study aims to investigate whether in twin pregnancies baseline maternal and obstetrical characteristics are potential indicators for CL , to improve insight in the pathophysiological pathway of PTB . STUDY DESIGN Secondary analysis of data on twin pregnancies and CL measurement between 16 and 22 weeks . A set of 10 potential indicators , known to be associated with an increased risk of PTB and/or which have a plausible mechanism resulting in a change of CL were selected . We used multivariable linear regression with backward selection to identify independent indicators for CL . RESULTS A total of 1,447 women with twin pregnancies were included . Mean CL was 43.7 ( ±8.9 ) mm . In multivariable analysis , age ( 0.27 mm/y ; 95 % confidence interval [ CI ] 0.16 to 0.39 ) , use of assisted reproductive technologies ( ART ) ( -1.42 mm , 95 % CI -2.6 to -0.25 ) , and having delivered at term in a previous pregnancy ( 1.32 mm , 95 % CI 0.25 to 2.39 ) were significantly associated with CL . CONCLUSION This study shows that in twin pregnancies , age , use of ART and having delivered term in a previous pregnancy has an association with CL .
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Intervention_Physical
CL measurement
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Outcome_Physical
Cervical length ( CL )
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Outcome_Physical
CL .
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Outcome_Physical
CL
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Outcome_Physical
analysis of data on twin pregnancies
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Outcome_Physical
CL measurement
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Outcome_Physical
a change of CL
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Outcome_Physical
indicators for CL .
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Outcome_Physical
Mean CL
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Participant_Condition
twin pregnancies
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Participant_Sample-size
1,447
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Participant_Sex
women
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Participant_Condition
twin pregnancies
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Participant_Condition
that in twin pregnancies