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document
Double-blind placebo-controlled comparison of the analgesic effects of single doses of lornoxicam and aspirin in patients with postoperative dental pain . The pain experienced after third molar surgery was used as a model to evaluate the analgesic efficacy of a new non-steroidal anti-inflammatory drug , lornoxicam , in a Phase II study . One hundred and fifty fit , young adults participated in this randomised , single dose , double-blind , parallel group clinical study . Three doses of lornoxicam ( 2 mg , 4 mg , and 8 mg ) were compared with aspirin 650 mg and placebo . Patients suffering from moderate to severe pain following surgery were monitored for up to 8 hours . All indices of efficacy showed similar results , all active treatments being associated with highly significant ( P less than 0.0001 ) reductions in pain during the study period . Lornoxicam 8 mg demonstrated significant analgesic efficacy as compared with placebo . The two lower doses of lornoxicam and aspirin all showed apparent degrees of efficacy intermediate between that of placebo and lornoxicam 8 mg , although the trial proved to have inadequate power to show significant differences between these three treatments . Lornoxicam was very well tolerated at all three doses studied , with no adverse events definitely attributable to its administration .
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
lornoxicam
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Intervention_Pharmacological
aspirin
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Intervention_Pharmacological
lornoxicam
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Intervention_Pharmacological
lornoxicam
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Intervention_Pharmacological
aspirin 650
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Intervention_Control
placebo
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Intervention_Pharmacological
Lornoxicam
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Intervention_Pharmacological
lornoxicam
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Intervention_Pharmacological
aspirin
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Outcome_Pain
analgesic effects
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Outcome_Pain
analgesic efficacy
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Outcome_Other
efficacy
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Outcome_Pain
reductions in pain
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Outcome_Pain
analgesic efficacy
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Outcome_Other
well tolerated
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Outcome_Adverse-effects
adverse events
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Participant_Condition
postoperative dental pain
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Participant_Sample-size
One hundred and fifty
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Participant_Age
young adults
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Participant_Condition
moderate to severe pain