11857
document
Topical imiquimod 5 % cream as an effective treatment for external genital and perianal warts in different patient populations . BACKGROUND Genital infection with human papillomavirus , the cause of genital warts , is one of the most common sexually transmitted diseases . GOAL The aim of this analysis was to determine whether patients ' demographic variables affect the efficacy of imiquimod 5 % cream versus vehicle cream for the treatment of external genital and perianal warts . STUDY DESIGN Male and female immunocompetent patients applied imiquimod 5 % cream topically to external genital warts 3 times a week until wart clearance or for up to 16 weeks . RESULTS As previously published , the intent-to-treat ( ITT ) clearance rate was 50 % ( 54/109 ) in the imiquimod-treated group and 11 % ( 11/100 ) in the vehicle-treated group ( P < 0.0001 ) . The ITT clearance rate in the imiquimod-treated group was higher in females ( 72 % ) than in males ( 33 % ) . We have examined the clearance rates for subgroups based on variables of gender , baseline wart area , duration of current outbreak of warts , previous wart treatment , and tobacco use . For each of these subgroups , imiquimod was statistically more effective than vehicle in eradicating external genital and perianal warts . CONCLUSION Imiquimod 5 % cream is an effective treatment for external genital and perianal warts and provides a significant benefit in comparison with vehicle cream , independent of gender , initial wart size , duration of current outbreak of warts , previous wart treatment , or tobacco use .
11858
Intervention_Pharmacological
imiquimod 5 % cream
11859
Intervention_Pharmacological
imiquimod 5 % cream
11860
Intervention_Control
vehicle cream
11861
Intervention_Pharmacological
imiquimod 5 % cream topically
11862
Intervention_Pharmacological
imiquimod-treated
11863
Intervention_Control
vehicle-treated
11864
Intervention_Pharmacological
imiquimod-treated
11865
Intervention_Pharmacological
imiquimod
11866
Intervention_Control
vehicle
11867
Intervention_Pharmacological
Imiquimod 5 % cream
11868
Intervention_Control
vehicle
11869
Outcome_Physical
genital and perianal
11870
Outcome_Physical
intent-to-treat ( ITT ) clearance rate
11871
Outcome_Physical
ITT clearance rate
11872
Outcome_Physical
variables of gender , baseline wart area , duration of current outbreak of warts , previous wart treatment , and tobacco use
11873
Outcome_Other
effective
11874
Outcome_Physical
eradicating external genital and perianal warts
11875
Outcome_Physical
external genital and perianal warts
11876
Outcome_Mental
wart treatment , or tobacco use
11877
Participant_Condition
external genital and perianal warts
11878
Participant_Condition
external genital and perianal warts
11879
Participant_Sex
Male
11880
Participant_Sex
female
11881
Participant_Condition
immunocompetent
11882
Participant_Condition
wart
11883
Participant_Condition
warts
11884
Participant_Condition
genital and perianal warts