16019
document
Clonidine treatment of hyperactive and impulsive children with autistic disorder . Many autistic children have associated problems of inattention , impulsivity , and hyperactivity that limit the effectiveness of educational and behavioral interventions . Few controlled psychopharmacologic trials have been conducted in autistic children to determine which agents may be effective for these associated features . Eight male children ( 8.1 +/- 2.8 years ) with autistic disorder , diagnosed by DSM-III-R criteria , completed a placebo-controlled , double-blind crossover trial of clonidine . Subjects were included in the study if they had inattention , impulsivity , and hyperactivity that was excessive for their developmental level . Subjects had not tolerated or responded to other psychopharmacologic treatments ( neuroleptics , methylphenidate , or desipramine ) . Teacher ratings on the Aberrant Behavior Checklist irritability , stereotypy , hyperactivity , and inappropriate speech factors were lower during treatment with clonidine than during treatment with placebo . Attention deficit disorder with hyperactivity : Comprehensive Teacher 's Rating Scale ratings were not significantly improved during the study , except for oppositional behavior . Parent Conners Abbreviated Parent-Teacher Questionnaire ratings significantly improved during clonidine treatment . Clonidine led to increased ratings of the side effects of drowsiness and decreased activity . Clinician ratings ( Children 's Psychiatric Rating Scale Autism , Hyperactivity , Anger and Speech Deviance factors ; Children 's Global Assessment Scale ; Clinical Global Impressions efficacy ) of videotaped sessions were not significantly different between clonidine and placebo . Clonidine was modestly effective in the short-term treatment of irritability and hyperactivity in some children with autistic disorder .
16020
Intervention_Pharmacological
Clonidine
16021
Intervention_Control
placebo-controlled
16022
Intervention_Pharmacological
clonidine
16023
Intervention_Pharmacological
neuroleptics
16024
Intervention_Pharmacological
methylphenidate
16025
Intervention_Pharmacological
desipramine
16026
Intervention_Pharmacological
clonidine
16027
Intervention_Control
placebo
16028
Intervention_Pharmacological
clonidine
16029
Intervention_Pharmacological
clonidine
16030
Intervention_Control
placebo
16031
Intervention_Pharmacological
Clonidine
16032
Outcome_Mental
inattention , impulsivity , and hyperactivity
16033
Outcome_Other
effective
16034
Outcome_Other
Teacher ratings on the
16035
Outcome_Mental
Aberrant Behavior Checklist irritability , stereotypy , hyperactivity , and inappropriate speech factors
16036
Outcome_Mental
Comprehensive Teacher 's Rating Scale ratings
16037
Outcome_Mental
Parent Conners Abbreviated Parent-Teacher Questionnaire ratings
16038
Outcome_Adverse-effects
side effects of drowsiness and decreased activity
16039
Outcome_Mental
Children 's Psychiatric Rating Scale Autism , Hyperactivity , Anger and Speech Deviance factors
16040
Outcome_Mental
Children 's Global Assessment Scale
16041
Outcome_Mental
Clinical Global Impressions efficacy
16042
Outcome_Mental
irritability and hyperactivity
16043
Participant_Condition
hyperactive and impulsive children with autistic disorder .
16044
Participant_Condition
children with autistic disorder .