86474
document
A community-based randomized trial of praziquantel to control schistosomiasis morbidity in schoolchildren in Zambia . A community-based , double-blind , randomized trial of praziquantel was carried out in an area of Zambia endemic for schistosomiasis . The aim of the study was to assess the impact of the treatment on Schistosoma mansoni morbidity . A total of 377 infected children , aged seven to 19 years , was randomized into two groups : one of 190 ( group A ) and one of 187 ( group B ) . All children were treated with 40 mg praziquantel/kg at the start of the study . Six months later , the children in group A were re-treated with the same dose of praziquantel , while the children in group B were given placebos . All children were followed up three , six and 12 months after the initial treatment , morbidity being clinically evaluated at the six- and 12-month follow-ups . The results show that , in both groups of children , there were significant reductions in splenomegaly , hepatomegaly , and subjective symptoms of morbidity six and 12 months after initial treatment . However , there were no significant differences , between the two groups , in the prevalences of these symptoms of morbidity . It therefore appears that once-yearly treatment of children , in this and similar endemic areas , is sufficient to reduce schistosomiasis morbidity to , and maintain it at , a tolerable level .
86475
Intervention_Pharmacological
praziquantel
86476
Intervention_Pharmacological
praziquantel
86477
Intervention_Pharmacological
praziquantel/kg
86478
Intervention_Pharmacological
praziquantel
86479
Intervention_Control
placebos
86480
Outcome_Physical
morbidity
86481
Outcome_Physical
splenomegaly , hepatomegaly , and subjective symptoms of morbidity
86482
Outcome_Physical
morbidity
86483
Participant_Age
schoolchildren
86484
Participant_Condition
schistosomiasis
86485
Participant_Age
children , aged seven to 19 years
86486
Participant_Age
children
86487
Participant_Age
children
86488
Participant_Age
children
86489
Participant_Age
children
86490
Participant_Age
children