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document
Effect of medical ozone therapy on renal blood flow and renal function of patients with chronic severe hepatitis . BACKGROUND Medical ozone therapy system was reported to have certain effects on the treatment of severe hepatitis , but its mechanism is not very clear . One of the causes of death of severe hepatitis is complication of renal damage or hepatorenal syndrome . The present study aimed to observe effects of medical ozone therapy system on plasma renin activity ( PRA ) , angiotensin II ( AII ) , aldosterone ( ALD ) , renal blood flow and renal function of patients with chronic severe hepatitis and explore mechanisms of medical ozone therapy in the treatment of severe hepatitis . METHODS Eighty-five cases with chronic severe hepatitis were randomly divided into ozone therapy group ( 43 cases ) and control group ( 42 cases ) . The patients in the ozone therapy group were treated with basic treatments plus ozone therapy system . Basic autohemotherapy was used . One hundred milliliter venous blood was drawn from each patient , and was mixed with 100 ml ( 35 µg/ml ) medical ozone and then was returned the blood to the patient intravenously , once every other day for 20 days . Only the basic treatments were given to the control group . PRA , AII , ALD , renal blood flow and damage to renal function of the two groups before treatment and 20 days after treatment were compared . Survival rates were also compared . RESULTS Twenty days after the treatment , in ozone therapy group , PRA was ( 1.31 ± 0.12 ) ng·ml⁻¹·h⁻¹ , AII ( 111.25 ± 17.35 ) pg/ml , ALD ( 251.31 ± 22.60 ) pg/ml , which decreased significantly compared with those before treatment ( PRA ( 2.23 ± 0.13 ) ng·ml⁻¹·h⁻¹ , AII ( 155.18 ± 19.13 ) pg/ml , ALD ( 405.31 ± 29.88 ) pg/ml , t = 4.67 - 14.23 , P < 0.01 ) , also lower than those of control group 20 days after the treatment ( PRA ( 2.02 ± 0.11 ) ng·ml⁻¹·h⁻¹ , AII ( 162.21 ± 15.32 ) pg/ml , ALD ( 401.20 ± 35.02 ) pg/ml , t = 4.97 - 15.61 , P < 0.01 ) ; renal blood flow was ( 175.15 ± 28.20 ) ml/min , which increased compared with that before the treatment ( ( 125.68 ± 21.25 ) ml/min ) and was higher than that of control group 20 days after the treatment ( ( 128.59 ± 23.15 ) ml/min , t = 4.78 , 4.61 , P < 0.01 ) . Renal damage occurred in 2 cases ( 5 % ) in ozone therapy group , less than that in control group ( 9 cases , 21 % ) ( χ² = 5.295 , P < 0.05 ) . Thirty-three cases ( 77 % ) in ozone therapy group vs. 16 cases ( 38 % ) in control group survived ( χ² = 12.993 , P < 0.01 ) . CONCLUSIONS Basic treatment plus medical ozone therapy for patients with chronic severe hepatitis could decrease PRA , AII and ALD levels significantly increase renal blood flow , prevent renal damage to certain extent and improve survival rate of the patients .
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Intervention_Pharmacological
medical ozone therapy
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Intervention_Pharmacological
Medical ozone therapy system
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Intervention_Pharmacological
medical ozone therapy system
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Intervention_Pharmacological
medical ozone therapy
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Intervention_Pharmacological
ozone therapy group
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Intervention_Control
control
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Intervention_Pharmacological
ozone therapy
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Intervention_Pharmacological
basic treatments plus ozone therapy system
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Intervention_Pharmacological
autohemotherapy
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Outcome_Physical
renal blood flow and renal function
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Outcome_Other
effects on the treatment of severe hepatitis
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Outcome_Physical
complication of renal damage
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Outcome_Adverse-effects
hepatorenal syndrome .
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Outcome_Physical
plasma renin activity ( PRA ) , angiotensin II ( AII ) , aldosterone ( ALD ) , renal blood flow and renal function
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Outcome_Other
Basic autohemotherapy
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Participant_Condition
patients with chronic severe hepatitis .
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Participant_Condition
severe hepatitis
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Participant_Sample-size
Eighty-five cases
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Participant_Condition
severe hepatitis
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Participant_Condition
treatment plus medical ozone therapy for