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document
Azelnidipine and amlodipine anti-coronary atherosclerosis trial in hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo university ( ALPS-J ) . PURPOSE Many trials have shown that calcium channel blockers ( CCBs ) can reduce the cardiovascular ( CV ) events in patients with coronary artery disease ( CAD ) . The mechanisms of this effect could be associated with plaque regression due to the anti-atherosclerotic properties of CCBs . The goal of this study is to determine the effects of CCB on volumetric quantitative changes of coronary plaques accessed by intravascular ultrasound ( IVUS ) . To confirm this hypothesis , a multicenter randomized trial of CCBs treatment with azelnidipine or amlodipine will be conducted in hypertensive CAD patients undergoing elective percutaneous coronary intervention ( PCI ) . METHODS AND RESULTS Patients who have hypertension and are scheduled for PCI will be enrolled . Subjects will be randomized to azelnidipine or amlodipine and observed for 48 weeks . The primary endpoint will be the percent change of coronary plaque volume . The secondary endpoint will include inflammatory markers , antioxidant activity , and incidence of composite cardiovascular events . CONCLUSIONS In this study , we will investigate the improvement of coronary plaque with IVUS by treatment with two dihydropyridine CCBs in hypertensive patients undergoing elective PCI . This result will lead to the discovery of more effective drug therapy for inhibition of coronary events .
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Intervention_Pharmacological
Azelnidipine
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Intervention_Pharmacological
amlodipine
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Intervention_Pharmacological
azelnidipine
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Intervention_Pharmacological
amlodipine
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Intervention_Pharmacological
azelnidipine
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Intervention_Pharmacological
amlodipine
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Outcome_Physical
cardiovascular ( CV ) events
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Outcome_Physical
percent change of coronary plaque volume
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Outcome_Physical
inflammatory markers , antioxidant activity , and incidence of composite cardiovascular events
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Outcome_Physical
coronary plaque
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Outcome_Physical
coronary events
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Participant_Condition
hypertensive patients undergoing coronary intervention by serial volumetric intravascular ultrasound analysis in Juntendo university ( ALPS-J )
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Participant_Condition
hypertensive CAD patients undergoing elective percutaneous coronary intervention ( PCI ) .
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Participant_Age
Patients who have hypertension and are scheduled for PCI will be enrolled .
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Participant_Condition
hypertensive patients undergoing elective PCI .