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Limited effects of micronutrient supplementation on strength and physical function after abdominal aortic aneurysmectomy . BACKGROUND Tissue injury following ischemia-reperfusion is mediated in part by free oxygen radicals . We hypothesized that perioperative micronutrient supplementation would augment antioxidant defenses , minimize muscle injury , and minimize postoperative decreases in muscle strength and physical function following abdominal aortic aneurysmectomy . SETTING A university-affiliated hospital and regional referral center . DESIGN A randomized , double-blind , placebo-controlled trial of supplementation with beta-carotene , vitamins C and E , zinc , and selenium for a period of 2-3 weeks prior to surgery and 1 week thereafter . STUDY POPULATION Patients undergoing elective abdominal aortic aneurysmectomy ( n=18 per group ) . PRINCIPAL MEASUREMENTS Handgrip and other measures of strength and physical function . RESULTS Handgrip and quadriceps strength decreased following surgery , but not to a significantly different extent in the placebo and supplemented groups . Self-rated physical function decreased following surgery in the placebo group and was preserved in the supplemented group . CONCLUSIONS Perioperative supplementation with micronutrients with antioxidant properties has limited effects on strength and physical function following major elective surgery .
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Intervention_Pharmacological
micronutrient supplementation
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Intervention_Pharmacological
micronutrient supplementation
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
supplementation with beta-carotene , vitamins C and E , zinc , and selenium
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Intervention_Surgical
abdominal aortic aneurysmectomy
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Intervention_Surgical
surgery
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Intervention_Pharmacological
Perioperative supplementation with micronutrients
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Outcome_Physical
strength and physical function
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Outcome_Physical
abdominal
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Outcome_Physical
augment antioxidant defenses ,
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Outcome_Other
minimize muscle injury
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Outcome_Physical
, and minimize postoperative decreases in muscle strength and physical function
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Outcome_Physical
Handgrip and other measures of strength and physical function
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Outcome_Physical
Handgrip and quadriceps strength
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Outcome_Physical
Self-rated physical function
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Outcome_Physical
strength and physical function
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Participant_Condition
abdominal aortic aneurysmectomy .
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Participant_Condition
abdominal aortic aneurysmectomy
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Participant_Sample-size
n=18