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document
Efficacy of artemisinin-based combination treatments of uncomplicated falciparum malaria in under-five-year-old Nigerian children . The efficacy of 3-day regimens of artemether-lumefantrine and artesunate-amodiaquine were evaluated in 747 children < 5 years of age with uncomplicated malaria from six geographical areas of Nigeria . Fever clearance was significantly faster ( P = 0.006 ) and the proportion of children with parasitemia 1 day after treatment began was significantly lower ( P = 0.016 ) in artesunate-amodiaquine-compared with artemether-lumefantrine-treated children . Parasite clearance times were similar with both treatments . Overall efficacy was 96.3 % ( 95 % confidence interval [ CI ] 94.5-97.6 % ) , and was similar for both regimens . Polymerase chain reaction-corrected parasitologic cure rates on Day 28 were 96.9 % ( 95 % CI 93.9-98.2 % ) and 98.3 % ( 95 % CI 96.1-99.3 % ) for artemether-lumefantrine and artesunate-amodiaquine , respectively . Gametocyte carriage post treatment was significantly lower than pretreatment ( P < 0.0001 ) . In anemic children , mean time to recovery from anemia was 10 days ( 95 % CI 9.04-10.9 ) and was similar for both regimens . Both treatments were well tolerated and are safe and efficacious treatments of uncomplicated falciparum malaria in young Nigerian children .
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Intervention_Pharmacological
artemisinin-based combination treatments
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Intervention_Pharmacological
artemether-lumefantrine
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Intervention_Pharmacological
artesunate-amodiaquine
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Intervention_Pharmacological
artemether-lumefantrine-treated
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Intervention_Pharmacological
artemether-lumefantrine
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Intervention_Pharmacological
artesunate-amodiaquine
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Outcome_Physical
clearance
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Outcome_Physical
Parasite clearance
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Outcome_Physical
parasitologic cure rates
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Outcome_Physical
Gametocyte carriage post treatment
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Outcome_Physical
mean time to recovery from anemia
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Outcome_Other
well tolerated and are safe and efficacious treatments
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Participant_Age
under-five-year-old
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Participant_Age
.
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Participant_Sample-size
747 children
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Participant_Age
< 5 years of age
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Participant_Condition
uncomplicated malaria
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Participant_Condition
anemic
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Participant_Age
children
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Participant_Age
young
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Participant_Age
children