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document
Atrial natriuretic factor inhibits metoclopramide stimulated aldosterone release in man . 1 . Atrial natriuretic factor ( ANF ) has an inhibitory effect on angiotensin II and ACTH stimulated aldosterone secretion in man . The selectivity of this aldosterone suppressing effect of ANF is unclear in man . The present study investigated the effect of ANF on the increase in plasma aldosterone due to metoclopramide in man . 2 . Eight normal male volunteers were studied on three occasions . Metoclopramide ( 10 mg slow i.v . ) was given on all study days and each volunteer was randomised to receive 45 min infusion of either 5 % D-glucose ( placebo ) or ANF ( 99-126 ) 3 or 15 pmol kg-1 min-1 . 3 . Metoclopramide increased plasma aldosterone to approximately 170 % of baseline levels ( P less than 0.01 ) . Concomitant infusion of ANF 3 pmol kg-1 min-1 and 15 pmol kg-1 min-1 significantly attenuated this rise in plasma aldosterone to approximately 130 % ( P less than 0.05 ) and 110 % ( P less than 0.01 ) of baseline values respectively . 4 . It is suggested , in the light of previous findings , that the inhibitory effect of ANF represents a non-selective action of ANF on aldosterone release .
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Intervention_Pharmacological
metoclopramide
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Intervention_Pharmacological
Metoclopramide
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Intervention_Pharmacological
5 % D-glucose
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Intervention_Control
placebo
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Intervention_Pharmacological
ANF
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Intervention_Pharmacological
pmol
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Intervention_Pharmacological
Metoclopramide
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Intervention_Pharmacological
ANF 3
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Outcome_Physical
aldosterone release
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Outcome_Physical
angiotensin II and ACTH stimulated aldosterone secretion
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Outcome_Physical
plasma aldosterone
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Outcome_Other
metoclopramide
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Outcome_Physical
plasma aldosterone
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Outcome_Physical
aldosterone release .
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Participant_Sex
man
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Participant_Sex
man
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Participant_Sample-size
Eight
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Participant_Condition
normal
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Participant_Sex
male