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document
[ Administration of tobramycin aerosols in patients with nosocomial pneumonia : a preliminary study ] . OBJECTIVE The aim of this study was to assess renal and respiratory tolerance of aerosolized tobramycin in intubated and mechanically ventilated patients with nosocomial pneumonia . PATIENTS AND METHODS This was a multicenter , randomized , double-blind , placebo controlled study . Thirty-eight mechanically ventilated patients with documented nosocomial pneumonia were included . Patients treated with intravenous betalactam and tobramycin were randomly allocated to receive aerosolized tobramycin ( 6 mg/kg/day , n = 21 ) or placebo ( n = 17 ) . The aerosol was administered via a pneumatic nebulizer once a day for 5 days . RESULTS Respiratory tolerance was good in all but two patients . No acute renal failure occurred . By day 10 , 7 patients in the tobramycin group ( 35 % ) had been extubated versus 3 in the placebo group ( 18.5 % , p = 0.18 ) . By day 28 , 6 patients had died ( 2 in the tobramycin group and 4 in the placebo group , p = 0.23 ) . CONCLUSION Aerosolized tobramycin was well tolerated in ventilated patients with documented nosocomial pneumonia .
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Intervention_Pharmacological
tobramycin aerosols
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Intervention_Pharmacological
tobramycin
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Intervention_Pharmacological
intravenous betalactam
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Intervention_Pharmacological
tobramycin
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Intervention_Pharmacological
aerosolized tobramycin
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Intervention_Pharmacological
aerosol
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Outcome_Physical
renal and respiratory tolerance
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Outcome_Other
Respiratory tolerance
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Outcome_Physical
No acute renal failure
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Outcome_Physical
extubated
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Outcome_Mortality
died
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Participant_Condition
patients with nosocomial pneumonia
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Participant_Condition
intubated and mechanically ventilated patients
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Participant_Condition
nosocomial pneumonia
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Participant_Sample-size
Thirty-eight
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Participant_Condition
mechanically ventilated patients with documented nosocomial pneumonia
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Participant_Condition
ventilated patients with documented nosocomial pneumonia