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document
Impact of triiodothyronine on the survival of high-risk patients undergoing open heart surgery . Experimental and clinical studies have shown the beneficial effects of triiodothyronine ( T3 ) following myocardial revascularization on cardiopulmonary bypass ( CPB ) . In this study , open-label T3 was administered to 68 high-risk patients undergoing open heart surgery . The New Jersey Risk Assessment was used to calculate the preoperative estimated surgical mortality . A loading dose of T3 was administered : ( a ) at release of the aortic cross-clamp , ( b ) whenever the patient became CPB dependent , ( c ) if the patient exhibited low cardiac output after discontinuing CPB and ( d ) as pretreatment before initiating CPB . All therapeutic modalities were followed by a continuous T3 infusion . Following T3 therapy , CPB was discontinued in all patients . Based upon discriminant analysis , a total of 26 deaths were expected from the entire group , but only 7 patients died , therefore , the observed mortality was reduced by 72 % ( p < 0.007 ) . The use of T3 had a major impact on reducing surgical mortality , and may be advocated as a new therapeutic modality in patients with high estimated mortality undergoing open heart surgery .
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Intervention_Pharmacological
triiodothyronine
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Intervention_Surgical
open heart surgery .
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Intervention_Pharmacological
triiodothyronine ( T3 )
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Intervention_Surgical
cardiopulmonary bypass ( CPB ) .
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Intervention_Pharmacological
T3
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Intervention_Pharmacological
T3
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Intervention_Pharmacological
T3
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Intervention_Pharmacological
T3 therapy
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Intervention_Surgical
CPB
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Intervention_Pharmacological
T3
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Outcome_Mortality
survival of high-risk patients
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Outcome_Other
beneficial effects
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Outcome_Mortality
New Jersey Risk Assessment
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Outcome_Mortality
preoperative estimated surgical mortality .
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Outcome_Mortality
deaths
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Outcome_Mortality
died
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Outcome_Mortality
observed mortality
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Outcome_Mortality
reducing surgical mortality
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Outcome_Mortality
estimated mortality
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Participant_Condition
high-risk patients undergoing open heart surgery
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Participant_Sample-size
68
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Participant_Condition
undergoing open heart surgery
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Participant_Condition
open heart surgery