81075
document
A randomized study comparing glucagon and hyoscine N-butyl bromide before endoscopic retrograde cholangiopancreatography . BACKGROUND This study tried to resolve whether glucagon is a better premedication for endoscopic retrograde cholangiopancreatography ( ERCP ) . METHODS We first measured the basal blood sugar and amylase levels . Then an endoscope was placed in the duodenum without premedication , and basal pulse and duodenal peristaltic rates were measured . ERCP began after studied subjects were randomly premedicated with either 1 mg glucagon ( n = 38 ) or 40 mg hyoscine N-butyl bromide ( n = 36 ) intravenously . Ten minutes later the variables were measured again . RESULTS Glucagon elicited hyperglycemia whereas hyoscine N-butyl bromide manifested an anticholinergic effect . No difference was found between these two groups with regard to the necessary interval for ERCP ( 20.6 +/- 14.1 min versus 21.4 +/- 14.7 min ; NS ) or the success rate for cholangiopancreatography ( 92.1 % versus 91.7 % ; NS ) . Neither hyperamylasemia nor pancreatitis was preventable when glucagon was used . CONCLUSIONS The two premedications appear equally effective in the performance of ERCP .
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Intervention_Pharmacological
glucagon
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Intervention_Pharmacological
hyoscine N-butyl bromide
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Intervention_Physical
endoscopic retrograde cholangiopancreatography
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Intervention_Pharmacological
glucagon
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Intervention_Pharmacological
1 mg glucagon
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Intervention_Pharmacological
40 mg hyoscine N-butyl bromide
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Intervention_Pharmacological
Glucagon
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Intervention_Pharmacological
hyoscine N-butyl bromide
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Intervention_Pharmacological
glucagon
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Outcome_Physical
endoscopic retrograde cholangiopancreatography ( ERCP )
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Outcome_Physical
basal blood sugar and amylase levels .
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Outcome_Physical
basal pulse and duodenal peristaltic rates
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Outcome_Physical
hyperglycemia
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Outcome_Physical
anticholinergic effect .
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Outcome_Other
necessary interval for ERCP
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Outcome_Other
success rate for cholangiopancreatography
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Outcome_Physical
hyperamylasemia nor pancreatitis
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Outcome_Other
performance of ERCP
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Participant_Condition
endoscopic retrograde cholangiopancreatography ( ERCP ) .
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Participant_Condition
1 mg glucagon ( n = 38 ) or 40 mg hyoscine N-butyl bromide ( n = 36 )