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document
An international multi-clinic study comparing the therapeutic efficacy of colloidal bismuth subcitrate coated tablets with chewing tablets in the treatment of duodenal ulceration . The results of a randomized , single-blind , multi-clinic study comparing the therapeutic efficacy and degree of oral staining of new colloidal bismuth subcitrate ( CBS ) coated tablets over 4 weeks of treatment in patients suffering from duodenal ulceration are reported . The data were collected from 9 clinics in the Netherlands , Belgium , Ireland , the United Kingdom , and Italy . The results from 94 patients treated with CBS coated tablets and 95 patients treated with CBS chewing tablets were statistically evaluated . Healing rates after 4 weeks of therapy appeared to be 76 % for CBS coated tablets and 72 % for CBS chewing tablets , so no statistically significant difference in therapeutic efficacy was seen . A highly significant degree of discolouration of all parts of the oral cavity was observed in patients treated with CBS chewing tablets , whereas only a few patients treated with CBS coated tablets experienced a slight staining of the tongue . Blood bismuth concentrations during the study had a range of less than or equal to 3 to 33 micrograms/l . The new CBS coated tablet form has an excellent patient compliance as compared to the chewing tablets .
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Intervention_Pharmacological
colloidal bismuth subcitrate coated tablets
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Intervention_Pharmacological
chewing tablets
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Intervention_Pharmacological
colloidal bismuth subcitrate ( CBS ) coated tablets
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Intervention_Pharmacological
CBS coated tablets
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Intervention_Pharmacological
CBS chewing tablets
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Intervention_Pharmacological
CBS coated tablets
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Intervention_Pharmacological
CBS chewing tablets
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Intervention_Pharmacological
CBS chewing tablets
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Intervention_Pharmacological
CBS coated tablets
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Intervention_Pharmacological
CBS coated tablet
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Intervention_Pharmacological
chewing tablets
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Outcome_Other
therapeutic efficacy and degree of oral staining
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Outcome_Physical
Healing rates
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Outcome_Physical
significant degree of discolouration of all parts of the oral cavity
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Outcome_Physical
slight staining of the tongue
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Outcome_Physical
Blood bismuth concentrations
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Outcome_Mental
excellent patient compliance
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Participant_Condition
multi-clinic study comparing the therapeutic efficacy and degree of oral staining of new colloidal bismuth subcitrate ( CBS ) coated tablets over 4 weeks of treatment in patients suffering from duodenal ulceration