58354
document
Association between weight loss and improvement of ventricular systolic function in advanced heart failure . In heart failure ( HF ) , longitudinal changes in ventricular ejection fraction are poorly studied . The authors ' objective was to document the dynamic changes in systolic function of both ventricles during acute HF and after a 3-month follow-up period , and to identify factors associated with ventricular improvement . A limited access dataset from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness ( ESCAPE ) trial provided by The National Heart , Lung , and Blood Institute was analyzed . In patients admitted to the hospital with acute HF , both ventricles were evaluated by echocardiography on admission , at discharge , and at 3 months . From baseline to 3 months , left ventricular ejection fraction ( LVEF ) increased in 43.4 % of patients , decreased in 23.9 % , and remained unchanged in 32.7 % . Similarly , right ventricular systolic function improved in 40.9 % , deteriorated in 25.0 % , and remained stable in 34.1 % . Weight loss during index admission and cardiac index/cardiac output increase were the only factors associated with LVEF improvement from baseline to month 3 . There was no difference between ischemic and nonischemic etiology . In acute HF , ischemic or nonischemic , systolic function of the ventricles improved during 3 months in about 40 % of patients and remained unchanged or deteriorated in the rest . Weight loss and increase in cardiac index/output during hospitalization was associated with improvement in LVEF .
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Intervention_Physical
weight loss
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Intervention_Physical
Weight loss
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Intervention_Physical
Weight loss
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Outcome_Physical
weight loss
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Outcome_Physical
improvement of ventricular systolic function
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Outcome_Physical
left ventricular ejection fraction ( LVEF )
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Outcome_Physical
right ventricular systolic function
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Outcome_Physical
Weight loss during index admission
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Outcome_Physical
cardiac index/cardiac output
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Outcome_Physical
ischemic or nonischemic , systolic function of the ventricles
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Outcome_Physical
Weight loss
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Outcome_Physical
cardiac index/output
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Outcome_Physical
LVEF .
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Participant_Condition
advanced heart failure
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Participant_Condition
Heart Failure
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Participant_Condition
acute HF