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document
Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes . To characterize the time course of plasma and red blood cell ( RBC ) changes after n-3 polyunsaturated fatty acid ( PUFA ) supplementation , 20 healthy male volunteers were randomly assigned to receive either four 1-g capsules of n-3 PUFA ethyl esters or four 1-g capsules of olive oil ( as placebo ) for a period of 4 mo , followed by a 3-mo washout period . Fatty acids of plasma and RBC phospholipid fractions were analyzed at 0 , 2 , and 4 mo of treatment and at 1 , 2 , and 3 mo of washout . During n-3 PUFA supplementation , accumulations of eicosapentaenoic ( EPA ) , docosapentaenoic ( DPA ) , and docosahexaenoic ( DHA ) acids were marked after 2 mo with differences among different fractions of plasma and RBCs in further accumulation up to 4 mo . During the first and second months of the washout , slight differences were observed in changes of various fatty acids among different phospholipid fractions , but after 3 mo of washout , only minor alterations were still detectable with respect to pretreatment values . These data confirm the complex relations among different fatty acid pools after n-3 PUFA supplementation .
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Intervention_Pharmacological
n-3 polyunsaturated fatty acid intake
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Intervention_Pharmacological
n-3 polyunsaturated fatty acid ( PUFA ) supplementation
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Intervention_Control
four 1-g capsules of n-3 PUFA ethyl esters or four 1-g capsules of olive oil ( as placebo )
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Intervention_Pharmacological
n-3 PUFA supplementation
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Intervention_Pharmacological
n-3 PUFA supplementation
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Outcome_Physical
Fatty acids of plasma
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Outcome_Physical
RBC phospholipid fractions
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Outcome_Physical
eicosapentaenoic ( EPA )
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Outcome_Physical
docosapentaenoic ( DPA )
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Outcome_Physical
docosahexaenoic ( DHA ) acids
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Outcome_Physical
changes of various fatty acids among different phospholipid fractions
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Outcome_Physical
different fatty acid pools