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document
Acute and late toxicity in a randomized trial of conventional versus hypofractionated three-dimensional conformal radiotherapy for prostate cancer . PURPOSE To compare the toxicity between hypofractionation vs. conventional fractionation schedules in patients with high-risk prostate cancer . METHODS AND MATERIALS Between January 2003 and December 2007 , 168 patients were randomized to receive either hypofractionated ( 62 Gy in 20 fractions within 5 weeks , 4 fractions/wk ) or conventionally fractionated ( 80 Gy in 40 fractions within 8 weeks ) three-dimensional conformal radiotherapy to the prostate and seminal vesicles . All patients had undergone a 9-month course of total androgen deprivation , with radiotherapy starting 2 months after initiation of the total androgen deprivation . RESULTS The median follow-up was 32 and 35 months in the hypofractionation and conventional fractionation arms , respectively . For the patients developing acute toxicity , no difference between the two fractionation groups was found in either severity or duration of gastrointestinal or genitourinary toxicity . Also , no difference was found in the incidence and severity of late gastrointestinal and genitourinary toxicity between the two treatment schedules , with a 3-year rate of Grade 2 or greater toxicity of 17 % and 16 % for the hypofractionation arm and 14 % and 11 % for the conventional fractionation arm , respectively . A statistically significant correlation between acute and late gastrointestinal toxicity was found only in the conventional fractionation group . CONCLUSION Our findings suggest that the hypofractionation regimen used in our study is safe , with only a slight , nonsignificant increase in tolerable and temporary acute toxicity compared with the conventional fractionation schedule . The severity and frequency of late complications was equivalent between the two treatment groups .
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Intervention_Pharmacological
conventional
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Intervention_Physical
hypofractionated three-dimensional conformal radiotherapy
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Intervention_Pharmacological
hypofractionation
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Intervention_Pharmacological
conventional fractionation
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Intervention_Physical
hypofractionated
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Intervention_Pharmacological
conventionally fractionated
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Intervention_Pharmacological
three-dimensional conformal radiotherapy
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Intervention_Physical
hypofractionation
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Outcome_Other
Acute and late toxicity
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Outcome_Other
severity or duration of gastrointestinal or genitourinary toxicity
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Outcome_Other
severity of late gastrointestinal and genitourinary toxicity
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Outcome_Other
acute and late gastrointestinal toxicity
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Outcome_Other
tolerable and temporary acute toxicity
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Participant_Condition
patients with high-risk prostate cancer .
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Participant_Age
All patients had undergone a 9-month course of total androgen deprivation , with radiotherapy starting 2 months after initiation of the total androgen deprivation .