81800
document
Comparison of eltanolone and thiopental in anaesthesia for termination of pregnancy . Eltanolone , a new steroid hypnotic , was compared to thiopental in short anaesthesia . Sixty unpremedicated , Asa 1-2 women were randomized to receive eltanolone 0.6 ( group E1 ) or 0.8 mg.kg-1 ( group E2 ) or thiopental 4 mg.kg-1 ( group T ) for induction of anaesthesia . One minute before induction glycopyrrolate 0.2 mg and alfentanil 15 micrograms.kg-1 i.v . were administered . If induction failed , additional boluses of the test drug were given . Anaesthesia was maintained with 67 % nitrous oxide in oxygen , and additional bolus doses of the test drug were given in a standardized fashion , if needed . Recovery was assessed by a research nurse blinded to the agent used . Mean +/- s.d . induction doss were 0.7 +/- 0.1 mg.kg-1 ( group E1 ) , 0.8 +/- 0.1 mg.kg-1 ( group E2 ) and 4.0 +/- 0.0 mg.kg-1 ( group T ) . Induction time was prolonged in the group E1 compared to the other two groups ( P < 0.05 ) . Side effects were few in all groups , but involuntary muscle movements or hypertonus occurred in 23 % of the patients in the eltanolone and in 3 % in the thiopental groups ( n.s ) . Early recovery ( eye opening , orientation and sitting ) was slower in both eltanolone groups compared to the thiopental group ( P < 0.01 ) . No differences between the groups were found in toleration of oral fluids , walking , voiding , postoperative analgesic requirements or postoperative nausea and vomiting . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
eltanolone
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Intervention_Pharmacological
thiopental
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Intervention_Pharmacological
Eltanolone
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Intervention_Pharmacological
eltanolone 0.6
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Intervention_Pharmacological
thiopental
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Intervention_Pharmacological
glycopyrrolate
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Intervention_Pharmacological
alfentanil
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Intervention_Pharmacological
nitrous oxide in oxygen
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Outcome_Physical
anaesthesia
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Outcome_Physical
Recovery
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Outcome_Physical
Mean +/- s.d . induction doss
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Outcome_Physical
Induction time
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Outcome_Physical
Side effects
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Outcome_Physical
involuntary muscle movements or hypertonus
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Outcome_Physical
Early recovery ( eye opening , orientation and sitting )
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Participant_Condition
termination
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Participant_Condition
pregnancy .
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Participant_Sample-size
Sixty