86271
document
Recurrence of condylomata acuminata following cryotherapy is not prevented by systemically administered interferon . OBJECTIVE To determine whether interferon alpha-2a , when utilised as adjuvant chemotherapy following ablation of condylomata acuminata ( genital warts ) by cryotherapy , is effective in the prevention of recurrences . DESIGN Randomised , placebo-controlled , double-blind study . Statistical analysis was by 2-tailed Fisher 's Exact Test . PATIENTS 97 patients with recurrent condylomata acuminata . INTERVENTION 49 patients were treated with cryotherapy plus subcutaneously administered interferon alpha-2a , and 48 received cryotherapy plus placebo . Of these , 36 and 37 patients , respectively , completed the study and were evaluable . MAIN OUTCOME MEASURE Clinical eradication of condylomata for six months following adjuvant chemotherapy . RESULTS By completion of the adjuvant chemotherapy , 10 ( 28 % ) interferon recipients and 16 ( 43 % ) placebo recipients experienced recurrences . At six months follow-up , 25 ( 69 % ) interferon and 27 ( 73 % ) placebo recipients experienced recurrences . In the six months following interferon therapy , only 31 % of interferon and 27 % of placebo recipients remained free of recurrences ( p = 0.99 ) . CONCLUSIONS Interferon alpha-2a administered subcutaneously offers no benefit as a chemotherapeutic adjuvant to cryotherapy when used alone in the therapy of genital warts in this population of patients with recurrent condylomata .
86272
Intervention_Pharmacological
cryotherapy
86273
Intervention_Pharmacological
interferon
86274
Intervention_Pharmacological
interferon alpha-2a
86275
Intervention_Pharmacological
adjuvant chemotherapy
86276
Intervention_Pharmacological
cryotherapy
86277
Intervention_Control
placebo-controlled
86278
Intervention_Pharmacological
cryotherapy plus subcutaneously administered interferon alpha-2a
86279
Intervention_Control
cryotherapy plus placebo
86280
Intervention_Pharmacological
chemotherapy
86281
Intervention_Pharmacological
adjuvant chemotherapy
86282
Intervention_Control
placebo
86283
Intervention_Pharmacological
interferon
86284
Intervention_Control
placebo
86285
Intervention_Pharmacological
interferon therapy
86286
Intervention_Pharmacological
interferon
86287
Intervention_Control
placebo
86288
Intervention_Pharmacological
Interferon alpha-2a
86289
Intervention_Pharmacological
chemotherapeutic adjuvant to cryotherapy
86290
Outcome_Physical
Recurrence of condylomata acuminata
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Outcome_Other
Clinical eradication of condylomata for six months
86292
Outcome_Other
adjuvant chemotherapy
86293
Outcome_Physical
recurrences
86294
Outcome_Other
experienced recurrences
86295
Outcome_Physical
free of recurrences
86296
Participant_Condition
condylomata acuminata following cryotherapy
86297
Participant_Sample-size
97 patients with recurrent condylomata acuminata
86298
Participant_Condition
.
86299
Participant_Condition
36 and 37 patients , respectively , completed the study
86300
Participant_Condition
population of patients with recurrent condylomata