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document
Effects of antihypertensive drugs on cognitive function in adolescents . The effects of clonidine and hydrochlorothiazide on cognitive function were studied in hypertensive adolescents requiring pharmacologic therapy for blood pressure control . Twenty-four adolescents with persistent blood pressure elevation ( greater than 95th % ) on placebo were randomized double blind to clonidine or hydrochlorothiazide treatment . A battery of cognitive tests were performed during the placebo phase and after 16 weeks of active therapy . Antihypertensive therapy resulted in significant blood pressure reduction ( p less than .01 ) . A slight interactive effect was observed in arithmetic performance ( p less than .05 ) . All other parameters of cognitive function were not affected by either treatment .
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Intervention_Pharmacological
antihypertensive
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Intervention_Pharmacological
clonidine
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Intervention_Pharmacological
hydrochlorothiazide
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Intervention_Pharmacological
clonidine
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Intervention_Pharmacological
hydrochlorothiazide
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Intervention_Pharmacological
Antihypertensive therapy
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Outcome_Mental
cognitive function
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Outcome_Mental
cognitive function
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Outcome_Physical
blood pressure
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Outcome_Mental
cognitive tests
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Outcome_Physical
blood pressure reduction
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Outcome_Mental
arithmetic performance
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Outcome_Mental
cognitive function
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Participant_Age
adolescents
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Participant_Condition
hypertensive
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Participant_Sample-size
Twenty-four
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Participant_Age
adolescents
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Participant_Condition
persistent blood pressure elevation ( greater than 95th % )