61960
document
A randomized , double-blind , placebo-controlled crossover study of Cappra® for the treatment of mild or mild to moderate erectile dysfunction in Thai male . Erectile dysfunction ( ED ) is one of the major health concerns affects the quality of life among Thai male . The treatment of ED by the first-line drugs is limited to a certain group of patients due to their side effects and costs . Alternative medicine can be beneficial for the treatment of ED . This is a randomized , double-blind , placebo-controlled , crossover study aimed to assess the efficacy and safety of Cappra ( ® ) , a traditional herbal medicine which was used in Thailand for decades , for the treatment of mild and mild to moderate ED in Thai patients . A total of 63 patients with mild or mild to moderate ED were randomized to receive Cappra ( ® ) or placebo for two weeks in the first period , followed by one week washout period . The patients were switched to the alternative treatment in the second period . The efficacy was assessed by the International Index of Erectile Function ( IIEF ) questionnaire and adverse events . Sixty one patients completed the study . There was an improvement of IIEF score for all domains in Cappra ( ® ) group compared with placebo group . The mean change of IIEF score from baseline for erectile function domain of Cappra ( ® ) was significantly higher than placebo ( 4.87 vs 3.44 , p = 0.032 ) . The most common adverse events were dizziness ( 13.3 % Cappra ( ® ) , 9.6 % placebo ) , face numbness ( 1.6 % Cappra ( ® ) , 0 % placebo ) , and tachycardia ( 1.6 % Cappra ( ® ) , 0 % placebo ) . The results from this study demonstrated that Cappra ( ® ) is effective and well-tolerated and can be used as alternative therapy for mild and mild to moderate ED .
61961
Intervention_Control
placebo-controlled
61962
Intervention_Pharmacological
Cappra
61963
Intervention_Control
placebo
61964
Outcome_Other
efficacy
61965
Outcome_Physical
IIEF score
61966
Outcome_Physical
mean change of IIEF score
61967
Outcome_Adverse-effects
dizziness
61968
Outcome_Adverse-effects
face numbness
61969
Outcome_Adverse-effects
tachycardia
61970
Participant_Condition
mild or mild to moderate erectile dysfunction in Thai
61971
Participant_Sex
male
61972
Participant_Sex
male
61973
Participant_Condition
of mild and mild to moderate ED in Thai patients
61974
Participant_Sample-size
63 patients
61975
Participant_Condition
mild or mild to moderate ED were randomized