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Differential response to resistance training in CHF according to ACE genotype . BACKGROUND The Angiotensin Converting Enzyme ( ACE ) gene may influence the risk of heart disease and the response to various forms of exercise training may be at least partly dependent on the ACE genotype . We aimed to determine the effect of ACE genotype on the response to moderate intensity circuit resistance training in chronic heart failure ( CHF ) patients . METHODS The relationship between ACE genotype and the response to 11weeks of resistance exercise training was determined in 37 CHF patients ( New York Heart Association Functional Class=2.3±0.5 ; left ventricular ejection fraction 28±7 % ; age 64±12years ; 32:5 male : female ) who were randomised to either resistance exercise ( n=19 ) or inactive control group ( n=18 ) . Outcome measures included V˙O ( 2peak ) , peak power output and muscle strength and endurance . ACE genotype was determined using standard methods . RESULTS At baseline , patients who were homozygous for the I allele had higher V˙O ( 2peak ) ( p=0.02 ) and peak power ( p=0.003 ) compared to patients who were homozygous for the D allele . Patients with the D allele , who were randomised to resistance training , compared to non-exercising controls , had greater peak power increases ( ID p < 0.001 ; DD p < 0.001 ) when compared with patients homozygous for the I allele , who did not improve . No significant genotype-dependent changes were observed in V˙O ( 2peak ) , muscle strength , muscle endurance or lactate threshold . CONCLUSION ACE genotype may have a role in exercise tolerance in CHF and could also influence the effectiveness of resistance training in this condition .
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Intervention_Other
resistance training
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Intervention_Other
resistance training
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Intervention_Physical
11weeks of resistance exercise training
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Outcome_Physical
V˙O ( 2peak )
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Outcome_Physical
peak power
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Outcome_Physical
V˙O ( 2peak )
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Outcome_Physical
muscle strength
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Outcome_Physical
muscle endurance
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Outcome_Physical
lactate threshold
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Participant_Condition
chronic heart failure
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Participant_Condition
CHF