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document
Field efficacy of an inactivated bivalent influenza vaccine in a multi-site swine production system during an outbreak of systemic porcine circovirus associated disease . Swine influenza ( SI ) is a disease of significance for the swine industry , and vaccination is often recommended as a way to reduce its impact on production . The efficacy of SI vaccines is well established under experimental conditions , but information about field efficacy is scarce . The objective of this study was to evaluate the efficacy of a commercial inactivated bivalent ( H1N1/H3N2 ) vaccine under conditions of natural exposure to a field SI variant . To accomplish our goal we used a randomized , blinded , field trial in 2 cohorts of finisher pigs in a multi-site swine production system located in southern Ontario . During the trial , this herd experienced an outbreak of porcine circovirus associated disease ( PCVAD ) . The efficacy of the SI vaccine was assessed through its effect on average daily weight gain , and serological responses to SI over time . The effect of vaccination on pig growth was different in the 2 cohorts . Weight gain was higher in vaccinated pigs than in control pigs in Cohort 1 , but was numerically higher for control pigs than for vaccinated pigs in Cohort 2 . Vaccination against swine influenza , in a herd experiencing an outbreak of PCVAD , was of questionable value .
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Intervention_Pharmacological
inactivated bivalent influenza vaccine
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Intervention_Pharmacological
SI vaccines
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Intervention_Pharmacological
commercial inactivated bivalent ( H1N1/H3N2 ) vaccine
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Intervention_Pharmacological
field SI variant
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Intervention_Pharmacological
SI vaccine
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Intervention_Pharmacological
vaccination
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Intervention_Pharmacological
Vaccination
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Outcome_Physical
efficacy of an inactivated bivalent influenza vaccine
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Outcome_Other
efficacy of the SI vaccine
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Outcome_Physical
average daily weight gain , and serological responses to SI over time
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Outcome_Other
effect of vaccination
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Outcome_Physical
pig growth
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Outcome_Physical
Weight gain
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Participant_Condition
multi-site swine production system during an outbreak of systemic porcine circovirus associated disease .
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Participant_Sample-size
2 cohorts