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Detection and quantification of the solid component in pulmonary subsolid nodules by semiautomatic segmentation . OBJECTIVE To determine whether semiautomatic volumetric software can differentiate part-solid from nonsolid pulmonary nodules and aid quantification of the solid component . METHODS As per reference standard , 115 nodules were differentiated into nonsolid and part-solid by two radiologists ; disagreements were adjudicated by a third radiologist . The diameters of solid components were measured manually . Semiautomatic volumetric measurements were used to identify and quantify a possible solid component , using different Hounsfield unit ( HU ) thresholds . The measurements were compared with the reference standard and manual measurements . RESULTS The reference standard detected a solid component in 86 nodules . Diagnosis of a solid component by semiautomatic software depended on the threshold chosen . A threshold of -300 HU resulted in the detection of a solid component in 75 nodules with good sensitivity ( 90 % ) and specificity ( 88 % ) . At a threshold of -130 HU , semiautomatic measurements of the diameter of the solid component ( mean 2.4 mm , SD 2.7 mm ) were comparable to manual measurements at the mediastinal window setting ( mean 2.3 mm , SD 2.5 mm [ p = 0.63 ] ) . CONCLUSION Semiautomatic segmentation of subsolid nodules could diagnose part-solid nodules and quantify the solid component similar to human observers . Performance depends on the attenuation segmentation thresholds . This method may prove useful in managing subsolid nodules . KEY POINTS • Semiautomatic segmentation can accurately differentiate nonsolid from part-solid pulmonary nodules • Semiautomatic segmentation can quantify the solid component similar to manual measurements • Semiautomatic segmentation may aid management of subsolid nodules following Fleischner Society recommendations • Performance for the segmentation of subsolid nodules depends on the chosen attenuation thresholds .
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Intervention_Physical
semiautomatic segmentation .
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Intervention_Other
semiautomatic volumetric software
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Outcome_Other
detection of a solid component
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Outcome_Other
solid component