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document
[ Sublingually administered captopril versus nifedipine in hypertension emergencies ] . Aim of the study was to assess the effectiveness and tolerability of sublingual captopril ( SLC ) versus sublingual nifedipine ( SLN ) in treating hypertensive emergencies . During hypertensive crises ( systolic blood pressure exceeding 200 mmHg and diastolic blood pressure exceeding 115 mmHg ) forty hypertensive patients received either 25 mg of SLC or 10 mg of SLN in a randomized single blind fashion . Blood pressure and heart rate were then controlled after 5 , 10 , 15 , 20 , 30 , 45 , 60 , 120 min . and , in 18 cases , up to the 8th hour from the administration . Our results showed : 1 ) a satisfactory control of the hypertensive crises in 80 % of patients treated with SLC with a significant blood pressure reduction after 10 min . ( 13/8 mmHg , p less than 0.02 ) , while the maximum hypotensive effect was achieved after 30 min . ( 52/36 mmHg , p less than 0.001 ) ; SLN was able to reduce blood pressure in 90 % of all the cases , with a significant reduction after 5 min . ( 15/11 mmHg , p less than 0.02 ) and hypotensive peak after 20 min ( 57/38 mmHg , p greater than 0.001 ) ; 2 ) no significant differences for hypotensive effectiveness between the two groups , but with SLC having a mildly delayed onset of action when compared to SLN ; 3 ) antihypertensive effect lasting for about 6 hours in patients treated with SLC and blood pressure progressively raising after 4 hours in patients who received SLN ; 4 ) a significant correlation between blood pressure reduction and blood pressure before drug administration in both groups ; a significant correlation between pretreatment PRA and antihypertensive effect in the SLC group . We conclude that both drugs are effective and useful in treating hypertensive emergencies . Anyway we think that in severe forms SLN should be preferred for the shorter time preceding onset of action .
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Intervention_Pharmacological
Sublingually administered captopril
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Intervention_Pharmacological
nifedipine
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Intervention_Pharmacological
sublingual captopril ( SLC )
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Intervention_Pharmacological
sublingual nifedipine ( SLN )
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Intervention_Pharmacological
SLN
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Intervention_Pharmacological
SLC
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Intervention_Pharmacological
SLN
51550
Intervention_Pharmacological
SLC
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Intervention_Pharmacological
SLN
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Intervention_Pharmacological
SLC
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Intervention_Pharmacological
SLN
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Intervention_Pharmacological
SLC
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Intervention_Pharmacological
SLN
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Outcome_Other
effectiveness and tolerability
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Outcome_Physical
Blood pressure and heart rate
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Outcome_Physical
control of the hypertensive crises
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Outcome_Physical
blood pressure
51560
Outcome_Physical
hypotensive effect
51561
Outcome_Physical
blood pressure
51562
Outcome_Physical
hypotensive peak
51563
Outcome_Physical
hypotensive effectiveness
51564
Outcome_Physical
onset of action
51565
Outcome_Physical
antihypertensive effect
51566
Outcome_Physical
blood pressure
51567
Outcome_Physical
blood pressure
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Outcome_Physical
blood pressure
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Outcome_Physical
treating hypertensive emergencies
51570
Outcome_Physical
onset of action
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Participant_Condition
hypertension emergencies
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Participant_Condition
hypertensive emergencies
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Participant_Condition
hypertensive crises ( systolic blood pressure exceeding 200 mmHg and diastolic blood pressure exceeding 115 mmHg
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Participant_Sample-size
forty
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Participant_Condition
hypertensive
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Participant_Condition
hypertensive emergencies