73373
document
Prospective trial of timing of bacillus Calmette-Guérin vaccination in Canadian Cree infants . We studied 184 Cree Indian infants in randomized , prospective fashion to assess the effect of age on lymphocyte sensitization to purified protein derivative ( PPD ) before and after and without bacillus Calmette-Guérin ( BCG ) vaccination . Lymphocyte responses to PPD , Candida , and streptokinase were measured at birth and at intervals later . The mean response of paired values from 26 infants without BCG vaccination rose for the PPD stimulation index ( SI ) from 2.7 at birth to 3.9 before 2 yr of age . The SI for both Candida and streptokinase for this group of infants rose significantly in the first 2 yr ( p less than 0.05 ) . In 66 infants who received BCG in the first 7 days of life , the PPD-SI rose from 3.1 to 35.3 ( p less than 0.001 ) . In 17 infants who received the vaccine later but before 9 months , it rose from 3.1 at birth to 24.9 , and in 14 who received it between 9 months and 2 yr , it rose from 2.2 to 52.9 . The lymphocyte responses to PPD after BCG in these two groups were significantly different ( p less than 0.05 ) . There was no evidence in the older infants that a raised PPD-SI before BCG vaccination affected lymphocyte sensitization by the vaccine . We conclude that increasing the age at vaccination with BCG from birth to more than 9 months enhances immunologic sensitization to PPD significantly in this population .
73374
Intervention_Pharmacological
bacillus Calmette-Guérin vaccination
73375
Intervention_Pharmacological
bacillus Calmette-Guérin ( BCG ) vaccination
73376
Outcome_Physical
lymphocyte responses
73377
Outcome_Physical
lymphocyte sensitization