78124
document
Acute intervention studies in patients with myocardial infarction using atenolol , propranolol , oxprenolol and disopyramide phosphate . The value of beta-blockade and of disopyramide phosphate in the immediate treatment of patients with suspected acute myocardial infarction was assessed in two placebo controlled trials . In the first study 388 patients with suspected acute myocardial infarction were randomly allocated to treatment with propranolol , atenolol , or placebo , and when analysed on an initial intention to treat basis there was no significant difference between the three groups in respect of the mortality at one year . In addition , there was no evidence to suggest that either atenolol , or propranolol reduced the incidence of 'serious ' ventricular arrhythmias in the coronary care unit . In the second study 473 patients with suspected acute myocardial infarction were randomly allocated to treatment with oxprenolol , disopyramide phosphate , or placebo . Again no significant differences were seen with respect to the mortality at six weeks . There was , however , a significantly increased incidence of heart failure in the group which received disopyramide phosphate . Patients who received this drug also showed a reduced number of dysrhythmic episodes on 24-hour ECG recordings , but this trend did not achieve statistical significance . These results suggest that none of the three beta-blockers tested nor disopyramide phosphate is likely to reduce the mortality from acute myocardial infarction when given prophylactically , although disopyramide phosphate does reduce the incidence of 'serious ' ventriicular arrhythmias .
78125
Intervention_Pharmacological
atenolol
78126
Intervention_Pharmacological
propranolol
78127
Intervention_Pharmacological
oxprenolol
78128
Intervention_Pharmacological
disopyramide phosphate
78129
Intervention_Pharmacological
beta-blockade
78130
Intervention_Pharmacological
disopyramide phosphate
78131
Intervention_Pharmacological
propranolol , atenolol
78132
Intervention_Control
placebo
78133
Intervention_Pharmacological
atenolol
78134
Intervention_Pharmacological
propranolol
78135
Intervention_Pharmacological
oxprenolol , disopyramide phosphate
78136
Intervention_Pharmacological
placebo
78137
Intervention_Pharmacological
disopyramide phosphate
78138
Intervention_Pharmacological
three beta-blockers
78139
Intervention_Pharmacological
disopyramide phosphate
78140
Intervention_Pharmacological
disopyramide phosphate
78141
Outcome_Mortality
mortality
78142
Outcome_Physical
of 'serious ' ventricular arrhythmias
78143
Outcome_Mortality
no significant differences
78144
Outcome_Mortality
mortality
78145
Outcome_Physical
incidence of heart failure
78146
Outcome_Physical
number of dysrhythmic episodes on 24-hour ECG recordings
78147
Outcome_Mortality
reduce the mortality from acute myocardial infarction
78148
Outcome_Physical
reduce the incidence of 'serious ' ventriicular arrhythmias
78149
Participant_Condition
myocardial infarction
78150
Participant_Condition
acute myocardial infarction
78151
Participant_Sample-size
388 patients
78152
Participant_Sample-size
473 patients
78153
Participant_Condition
acute myocardial infarction