59799
document
Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus . Recently , nicotinic acid has been recommended as a first-line hypolipidemic drug . To determine the effectiveness of nicotinic acid in dyslipidemic patients with non-insulin-dependent diabetes mellitus , 13 patients were treated in a randomized crossover trial . Patients received either nicotinic acid ( 1.5 g three times daily ) or no therapy ( control period ) for 8 weeks each . Compared with the control period , nicotinic acid therapy reduced the plasma total cholesterol level by 24 % , plasma triglyceride level by 45 % , very-low-density lipoprotein cholesterol level by 58 % , and low-density lipoprotein cholesterol level by 15 % , and it increased the high-density lipoprotein cholesterol level by 34 % . However , nicotinic acid therapy resulted in the deterioration of glycemic control , as evidenced by a 16 % increase in mean plasma glucose concentrations , a 21 % increase in glycosylated hemoglobin levels , and the induction of marked glycosuria in some patients . Furthermore , a consistent increase in plasma uric acid levels was observed . Therefore , despite improvement in lipid and lipoprotein concentrations , because of worsening hyperglycemia and the development of hyperuricemia , nicotinic acid must be used with caution in patients with non-insulin-dependent diabetes mellitus with dyslipidemia . We suggest that the drug not be used as a first-line hypolipidemic drug in patients with non-insulin-dependent diabetes mellitus .
59800
Intervention_Pharmacological
Nicotinic acid
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Intervention_Pharmacological
nicotinic acid
59802
Intervention_Pharmacological
nicotinic acid
59803
Intervention_Control
no therapy
59804
Intervention_Pharmacological
nicotinic acid
59805
Intervention_Pharmacological
nicotinic acid
59806
Outcome_Physical
plasma total cholesterol level
59807
Outcome_Physical
plasma triglyceride level
59808
Outcome_Physical
very-low-density lipoprotein cholesterol level
59809
Outcome_Physical
low-density lipoprotein cholesterol level
59810
Outcome_Physical
high-density lipoprotein cholesterol level
59811
Outcome_Physical
deterioration of glycemic control
59812
Outcome_Physical
mean plasma glucose concentrations
59813
Outcome_Physical
glycosylated hemoglobin levels
59814
Outcome_Physical
marked glycosuria
59815
Outcome_Physical
plasma uric acid levels
59816
Outcome_Physical
lipid and lipoprotein concentrations
59817
Outcome_Physical
hyperglycemia
59818
Outcome_Physical
hyperuricemia
59819
Participant_Condition
non-insulin-dependent diabetes mellitus .
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Participant_Condition
dyslipidemic patients with non-insulin-dependent diabetes mellitus , 13 patients were treated in a randomized crossover trial .