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Influence of exercise training on leptin levels in patients with stable coronary artery disease : A pilot study . BACKGROUND This study was designed to examine the influence of exercise training on leptin levels in patients with stable coronary artery disease ( CAD ) . METHODS Sixty-four male patients , mean age 55.6 ± 6.0 years , were randomized either to six weeks of aerobic training , three times a week , at 60-80 % of maximal heart rate ( training group , Ex , n = 32 ) or to a control group ( n = 32 ) . Exercise stress test was performed and body mass index ( BMI ) , waist-to-hip ratio ( WHR ) , waist circumference and plasma leptin levels were measured at the beginning and end of the study . RESULTS Physical capacity increased significantly only in Ex patients ( max workload in METs from 7.7 ± 1.4 to 8.2 ± 1.4 , p < 0.05 ) . There were no significant differences between initial and final results in either group in terms of BMI , WHR or waist circumference . Although , at the end of the study , leptin levels did not change in Ex patients ( 6.7 ± 3.2 vs 6.9 ± 3.6 ng/mL , NS ) , they did increase significantly in the control group ( 8.0 ± 4.0 vs 9.3 ± 5.2 ng/mL , p < 0.02 ) . CONCLUSIONS A short period of exercise training in CAD patients improved their physical capacity , but did not influence BMI , WHR and waist circumference . Exercise training prevented an increase in leptin levels during the study period .
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Intervention_Physical
exercise training
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Intervention_Physical
exercise training
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Outcome_Physical
leptin levels
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Participant_Condition
patients with stable coronary artery disease
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Participant_Condition
coronary artery disease
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Participant_Sample-size
Sixty-four
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Participant_Sex
male
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Participant_Age
mean age 55.6 ± 6.0 years
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Participant_Condition
CAD