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document
Assessment of response to induction therapy and its influence on 5-year failure-free survival in group III rhabdomyosarcoma : the Intergroup Rhabdomyosarcoma Study-IV experience -- a report from the Soft Tissue Sarcoma Committee of the Children 's Oncology Group . PURPOSE Initial response to induction chemotherapy predicts failure-free survival ( FFS ) in osteosarcoma and Ewing 's sarcoma . For Intergroup Rhabdomyosarcoma Study ( IRS ) IV patients with group III rhabdomyosarcoma , we assessed whether reported response assessed by anatomic imaging at week 8 predicted FFS . PATIENTS AND METHODS We studied 444 group III patients who received induction therapy , had response assessed at week 8 by anatomic imaging , and continued with protocol therapy . Induction chemotherapy was generally followed by radiation therapy ( RT ) starting after week 9 . Response to induction therapy was determined at weeks 0 and 8 . Local institutions coded response . RESULTS Response rate for the entire cohort at week 8 was 77 % ( 95 % CI , 73 % to 81 % ; complete response [ CR ] , 21 % ; partial response [ PR ] , 56 % ) but response had no influence on FFS ( P = .57 ) . Two hundred seventy-two patients received standard-timing RT at week 9 and thus only chemotherapy during induction . Response rate was 81 % ( 95 % CI , 76 % to 86 % ; CR , 22 % ; PR , 59 % ) . In these patients , response did not influence FFS except for those with alveolar histology . One hundred thirty-two other patients received chemotherapy and RT during induction ( up-front RT ) . Response rate was 65 % ( 95 % CI , 57 % to 73 % ; CR , 12 % ; PR , 53 % ) , but response had no influence on FFS ( P = .69 ) . Forty patients received no RT at all ( protocol violation ) and response to induction therapy had no effect on FFS . CONCLUSION In IRS-IV , response rate to induction therapy was 77 % in group III patients , was independent of histology , and had no influence on FFS overall .
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Intervention_Pharmacological
induction chemotherapy
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Intervention_Pharmacological
induction therapy
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Intervention_Physical
anatomic imaging
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Intervention_Physical
continued with protocol therapy
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Intervention_Pharmacological
Induction chemotherapy
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Intervention_Physical
radiation therapy ( RT )
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Outcome_Mortality
5-year failure-free survival
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Outcome_Mortality
failure-free survival ( FFS )
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Outcome_Other
Response rate
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Outcome_Other
complete response [ CR ]
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Outcome_Other
partial response [ PR ]
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Outcome_Mortality
FFS
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Outcome_Other
Response rate
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Outcome_Other
CR
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Outcome_Other
PR
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Outcome_Mortality
did not influence FFS
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Outcome_Other
Response rate
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Outcome_Other
CR
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Outcome_Other
PR
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Outcome_Mortality
FFS
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Outcome_Mortality
FFS
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Outcome_Other
response rate
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Outcome_Mortality
FFS