75990
document
A prospective study of streptokinase and heparin in the treatment of deep vein thrombosis . In a prospective trial , 42 medical patients with a history of deep vein thrombosis of less than five days were allocated at random to treatment with streptokinase or heparin . Only patients with extensive thromboses were included . Streptokinase was given in a loading dose of 250 000 IU and a maintenance dose of 100 000 IU/hour for 4 days as a mean . Heparin was given in a loading dose of 15 000 IU and a maintenance dose of 20 000-50 000 IU/day . The therapeutic results were evaluated by phlebography . Significant thrombolysis occurred in 71.4 % of 21 patients treated with streptokinase and in 23.8 % of the 21 heparin-treated patients . Using the chi2-test for overall association , this difference was statistically highly significant ( p = 0.002 ) . Three patients in each treatment group experienced major bleeding , two in each group requiring blood transfusions . Minor bleeding and slight rise in temperature were encountered more often in the streptokinase than in the heparin group . It is concluded that patients with acute deep vein thrombosis with proximal extension of the thrombus beyond the calf veins should be offered a therapeutic trial with streptokinase .
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Intervention_Pharmacological
streptokinase
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Intervention_Pharmacological
heparin
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Intervention_Pharmacological
streptokinase
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Intervention_Pharmacological
heparin .
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Intervention_Pharmacological
Streptokinase
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Intervention_Pharmacological
Heparin
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Intervention_Pharmacological
streptokinase
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Intervention_Pharmacological
heparin-treated
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Intervention_Pharmacological
streptokinase
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Intervention_Pharmacological
heparin
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Intervention_Pharmacological
streptokinase .
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Outcome_Physical
deep vein thrombosis
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Outcome_Physical
Significant thrombolysis
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Outcome_Physical
major bleeding
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Outcome_Physical
blood transfusions
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Outcome_Adverse-effects
Minor bleeding
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Outcome_Physical
and slight rise in temperature
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Participant_Condition
deep vein thrombosis
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Participant_Sample-size
42 medical patients
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Participant_Condition
with a history of deep vein thrombosis of less than five days