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document
Randomized controlled study of chemoprophylaxis in transurethral prostatectomy . We studied 599 evaluable patients with benign prostatic hypertrophy at 7 urological units . Before transurethral prostatectomy the patients were randomized into 3 groups : group 1 -- 197 patients given single-dose ceftriaxone ( 2 gm . ) , group 2 -- 203 patients given 160/800 mg. trimethoprimsulfamethoxazole and group 3 -- 199 controls given no antimicrobial prophylaxis . Patients with a preoperative indwelling catheter , positive urine culture , signs of active infection or preoperative antibiotic treatment were excluded . Postoperative infectious complications were demonstrated in 15 of 197 ( 7.6 % ) , 25 of 203 ( 12.3 % ) and 43 of 199 ( 21.6 % ) patients in the study groups , respectively . The difference in infectious complications between groups 1 and 3 was statistically highly significant ( p < 0.01 ) and between groups 2 and 3 it was significant ( p < 0.05 ) . Single-dose antibiotic prophylaxis proved to be useful in the prevention of serious infectious complications after transurethral prostatectomy .
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Intervention_Pharmacological
single-dose ceftriaxone
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Intervention_Pharmacological
trimethoprimsulfamethoxazole
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Intervention_Control
controls
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Outcome_Adverse-effects
Postoperative infectious complications
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Outcome_Physical
infectious complications
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Outcome_Physical
serious infectious complications
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Participant_Condition
transurethral prostatectomy .
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Participant_Sample-size
599
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Participant_Condition
benign prostatic hypertrophy
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Participant_Sample-size
197
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Participant_Sample-size
203
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Participant_Sample-size
199