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document
Contrast , motion , perceptual integration , and neurocognition in schizophrenia : the role of fragile-X related mechanisms . Recent studies demonstrated a reduced expression of Fragile X Mental Retardation Protein ( FMRP ) , an RNA binding protein and translation regulator , in the brain and peripheral lymphocytes of patients with schizophrenia . Low FMRP levels may be related to impaired neurodevelopmental processes and synaptic plasticity . Here , we studied the relationship between peripheral FMRP level , visual perception ( contrast sensitivity , perceptual integration , motion/form perception ) , and neuropsychological functions in schizophrenia as measured with the Repeatable Battery for the Assessment of Neuropsychological Status ( RBANS ) . Results revealed that patients with schizophrenia displayed lower FMRP levels in peripheral lymphocytes as compared to control individuals . We found significant correlations between FMRP levels and contrast sensitivity at low spatial and high temporal frequencies , perceptual integration , and motion perception . The relationship between FMRP level and neuropsychological functions was less pronounced than that seen in the case of visual perception , with the greatest effect for RBANS attention . FMRP level was not related to contrast sensitivity at high spatial and low temporal frequencies and form perception . This pattern of data is reminiscent to that observed in patients with Fragile X Syndrome ( FXS ) . These results suggest that FMRP may be implicated in the pathogenesis of schizophrenia , possibly via the regulation of neurodevelopment , plasticity , GABA-ergic , and glutamatergic neurotransmission .
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Outcome_Mental
visual perception ( contrast sensitivity , perceptual integration , motion/form perception ) , and neuropsychological functions
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Outcome_Physical
FMRP levels
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Outcome_Physical
FMRP levels
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Outcome_Physical
FMRP level and neuropsychological functions
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Outcome_Physical
FMRP level
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Outcome_Physical
neurodevelopment
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Outcome_Physical
plasticity
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Outcome_Physical
GABA-ergic
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Outcome_Physical
glutamatergic neurotransmission .
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Participant_Condition
patients with schizophrenia
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Participant_Condition
schizophrenia