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document
Triple combination as adjuvant to cryotherapy in the treatment of solar lentigines : investigator-blinded , randomized clinical trial . BACKGROUND Post-inflammatory hyperpigmentation is a frequent concern when treating solar lentigines . OBJECTIVES To assess the safety and efficacy of a triple combination cream with fluocinolone acetonide 0.01 % , hydroquinone 4 % and tretinoin 0.05 % as adjuvant to cryotherapy in the treatment of solar lentigines in hands dorsum , and in the prevention of post-inflammatory hyperpigmentation after cryotherapy . METHODS This prospective , randomized , controlled , investigator-blinded , single-centre study enrolled 50 patients . Twenty-five patients received a 2-week daily triple combination cream plus sunscreen pre-treatment and 25 received sunscreen alone . After that , cryotherapy was performed in all patients followed by a 3-week recovery period . After this period , patients received the same initial treatment and were followed up for 8 weeks . Melanin and erythema levels of a target and a control lentigo were objectively measured using a narrowband reflectance spectrophotometer . Lentigines count , colour homogeneity and global improvement were also assessed . RESULTS The number of solar lentigines reduced in the first 2 weeks only in patients who used the triple combination 25 ± 7 vs. 22 ± 8 ( P < 0.0001 ) , and reduced at the end of the study for both groups ( P < 0.0001 ) . The melanin levels also reduced in the first 2 weeks only in patients who used the triple combination 297 ± 69 vs. 273 ± 66 ( P < 0.0001 ) and reduced at the end of the study for both groups ( P < 0.0001 ) . Erythema and residual blisters from cryotherapy were the reported adverse reactions . CONCLUSION Triple combination cream can be used to enhance the resolution of solar lentigines , and to significantly reduce melanin levels and lentigines count , improving treatment results . It was well-tolerated and did not increase the occurrence of neither erythema nor other side-effects after the cryotherapy .
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Intervention_Physical
Triple combination as adjuvant to cryotherapy
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Intervention_Pharmacological
triple combination cream with fluocinolone acetonide
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Intervention_Pharmacological
hydroquinone
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Intervention_Pharmacological
tretinoin
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Intervention_Physical
2-week daily triple combination cream plus sunscreen pre-treatment
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Intervention_Control
sunscreen alone
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Intervention_Physical
cryotherapy
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Outcome_Physical
treatment of solar lentigines :
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Outcome_Physical
hyperpigmentation
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Outcome_Physical
solar lentigines .
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Outcome_Other
safety
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Outcome_Other
efficacy
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Outcome_Physical
treatment of solar lentigines
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Outcome_Physical
prevention of post-inflammatory hyperpigmentation
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Participant_Condition
solar lentigines
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Participant_Sample-size
50
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Participant_Sample-size
Twenty-five patients
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Participant_Sample-size
25