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document
Postoperative magnesium sulphate infusion reduces analgesic requirements in spinal anaesthesia . BACKGROUND AND OBJECTIVES Magnesium sulphate infusion during general anaesthesia reduces anaesthetic consumption and analgesic requirements . The aim of this study was to assess the effects of postoperative magnesium infusion on duration of block , sedation and analgesic consumption after spinal anaesthesia . METHODS Fifty ASA I-II patients were included in the randomized double blind study . Spinal anaesthesia was performed at L3-4 or L4-5 interspace with 12.5 mg 0.5 % heavy bupivacaine , using a 25 G Quincke needle . Patients received a 5 mg kg ( -1 ) bolus of magnesium sulphate followed by a 500 mg h ( -1 ) infusion or saline in the same volumes for 24 h. Time to first pain , analgesic request , return of motor function , visual analogue pain and sedation scores were evaluated every 4 h during the 24 h postoperative period . The t- and U-tests were used for statistical analyses . Data were expressed as mean +/- SD , with P < 0.05 being considered significant . RESULTS Vital signs were stable during spinal anaesthesia and postoperative period . When compared to the control group , time to analgesic need was increased and total analgesic consumption was reduced in the magnesium group ( meperidine consumption 60.0 +/- 73.1 mg control group , 31.8 +/- 30.7 mg magnesium group , P = 0.02 ) . CONCLUSIONS Magnesium sulphate infusion may be used as an adjunct for reducing analgesic consumption after spinal anaesthesia .
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Intervention_Pharmacological
magnesium sulphate infusion
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Intervention_Pharmacological
Magnesium sulphate
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Intervention_Pharmacological
magnesium
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Intervention_Surgical
Spinal anaesthesia was performed at L3-4 or L4-5 interspace with 12.5 mg 0.5 % heavy bupivacaine , using a 25 G Quincke needle
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Intervention_Pharmacological
5 mg kg ( -1 ) bolus of magnesium sulphate followed by a 500 mg h ( -1 ) infusion or saline
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Intervention_Pharmacological
Magnesium sulphate
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Outcome_Physical
anaesthetic consumption
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Outcome_Physical
analgesic requirements .
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Outcome_Physical
duration of block , sedation and analgesic consumption
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Outcome_Pain
Time to first pain , analgesic request
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Outcome_Physical
return of motor function
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Outcome_Pain
visual analogue pain
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Outcome_Physical
sedation scores
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Outcome_Physical
Vital signs
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Outcome_Pain
time to analgesic need
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Outcome_Pain
total analgesic consumption
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Outcome_Pain
analgesic consumption
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Participant_Sample-size
Fifty
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Participant_Condition
ASA I-II patients
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Participant_Condition
after spinal anaesthesia