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document
Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate . The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes ( CPP-ACP : Recaldent ) . The study utilized a double-blind , randomized , crossover design with two treatments : ( i ) sugar-free gum containing 18.8 mg of CPP-ACP , and ( ii ) sugar-free gum not containing CPP-ACP as control . Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 days . After each treatment the enamel slabs were removed and half of each lesion challenged with acid in vitro for 8 or 16 h. The level of remineralization was determined using microradiography . The gum containing CPP-ACP produced approximately twice the level of remineralization as the control sugar-free gum . The 8- and 16-hour acid challenge of the lesions remineralized with the control gum resulted in 65.4 and 88.0 % reductions , respectively , of deposited mineral , while for the CPP-ACP-remineralized lesions the corresponding reductions were 30.5 and 41.8 % . The acid challenge after in situ remineralization for both control and CPP-ACP-treated lesions resulted in demineralization underneath the remineralized zone , indicating that the remineralized mineral was more resistant to subsequent acid challenge . The results show that sugar-free gum containing CPP-ACP is superior to an equivalent gum not containing CPP-ACP in remineralization of enamel subsurface lesions in situ with mineral that is more resistant to subsequent acid challenge .
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Intervention_Pharmacological
sugar-free chewing gum
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Intervention_Pharmacological
sugar-free gum
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Intervention_Pharmacological
CPP-ACP
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Intervention_Control
sugar-free gum not containing CPP-ACP
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Intervention_Pharmacological
gum for
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Intervention_Pharmacological
gum containing CPP-ACP
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Intervention_Control
control gum
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Intervention_Pharmacological
sugar-free gum containing CPP-ACP
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Intervention_Control
gum
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Outcome_Physical
Acid resistance
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Outcome_Physical
acid resistance
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Outcome_Other
challenged with acid
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Outcome_Physical
in vitro
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Outcome_Physical
level of remineralization
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Outcome_Other
microradiography
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Outcome_Physical
level of remineralization
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Outcome_Physical
lesions remineralized
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Outcome_Physical
demineralization
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Outcome_Physical
more resistant
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Participant_Condition
enamel subsurface lesions
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Participant_Condition
enamel lesions
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Participant_Condition
subsurface lesions