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document
Hemodynamic effects during induction , laryngoscopy , and intubation with eltanolone ( 5 beta-pregnanolone ) or propofol . A study in ASA I and II patients . STUDY OBJECTIVE To evaluate the cardiovascular changes following induction of anesthesia , laryngoscopy , and intubation in patients receiving a bolus dose of either eltanolone or propofol . DESIGN Randomized , controlled , blind , prospective clinical study . SETTING General operating theaters of a university hospital . PATIENTS 40 ASA status I and II patients scheduled for elective surgery . INTERVENTIONS Patients were premedicated with oral temazepam 20 mg. Anesthesia was induced with either eltanolone 0.58 mg/kg or propofol 1.7 mg/kg , neuromuscular blockade was achieved with vecuronium 0.1 mg/kg , and anesthesia was maintained with enflurane 0.5 % to 1.0 % in nitrous oxide ( 67 % ) . MEASUREMENTS AND MAIN RESULTS Blood pressure was measured using an automatic oscillometric technique , heart rate ( HR ) was derived from the ECG , oxygen saturation was measured by pulse oximetry , and cardiac output ( Q ) was measured by a thoracic bioimpedance technique . Induction of anesthesia with either drug , eltanolone or propofol , decreased arterial systolic ( SAP ) and diastolic ( DAP ) blood pressure , Q , and stroke volume ( SV ) . HR increased . Systemic vascular resistance ( SVR ) was unaltered . After laryngoscopy and intubation , SAP and DAP increased secondary to an increase in SVR . HR also increased ; SV decreased in patients receiving eltanolone . Side effects ( e.g. , apnea occurring for more than 30 seconds , involuntary movements , limb hypertonus ) occurred at a similar incidence with both treatments , but pain following injection was greater with propofol ( 59 % vs. 9 % ) . CONCLUSIONS Patients receiving either eltanolone or propofol showed similar cardiovascular changes to induction of anesthesia , although there were greater increases in arterial pressure and HR in those patients receiving eltanolone .
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Intervention_Pharmacological
eltanolone ( 5 beta-pregnanolone )
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Intervention_Pharmacological
propofol .
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Intervention_Pharmacological
eltanolone
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Intervention_Pharmacological
propofol .
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Intervention_Pharmacological
premedicated with oral temazepam 20 mg. Anesthesia
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Intervention_Pharmacological
eltanolone 0.58 mg/kg or propofol 1.7 mg/kg , neuromuscular blockade was achieved with vecuronium 0.1 mg/kg , and anesthesia was maintained with enflurane 0.5 % to 1.0 % in nitrous oxide ( 67 % ) .
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Intervention_Pharmacological
eltanolone
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Intervention_Pharmacological
propofol
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Outcome_Physical
Blood pressure
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Outcome_Physical
automatic oscillometric technique
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Outcome_Physical
heart rate ( HR )
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Outcome_Physical
oxygen saturation
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Outcome_Physical
cardiac output ( Q )
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Outcome_Physical
arterial systolic ( SAP )
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Outcome_Physical
diastolic ( DAP ) blood pressure , Q
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Outcome_Physical
stroke volume ( SV )
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Outcome_Physical
HR
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Outcome_Physical
Systemic vascular resistance ( SVR )
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Outcome_Physical
SAP
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Outcome_Physical
DAP
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Outcome_Physical
SVR
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Outcome_Physical
HR
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Outcome_Physical
SV
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Outcome_Adverse-effects
apnea occurring for more than 30 seconds , involuntary movements , limb hypertonus
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Participant_Condition
ASA I and II patients
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Participant_Condition
scheduled for elective surgery