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document
Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis : a randomized controlled trial . OBJECTIVE To investigate the effect of rhubarb combined with early enteral nutrition ( EEN ) on the gastrointestinal function , disease severity and systemic inflammation in patients with severe acute pancreatitis ( SAP ) . METHODS A total of 126 patients with SAP were randomly assigned into three groups : parenteral nutrition group , treated with standard solution first and EN 14 days later ; EEN group , treated with EN suspension ; or EEN combined with rhubarb group , treated with rhubarb and then EN 2 h later . The gastrointestinal function , APACHE II scores , the levels of plasma IL-6 , IL-11 , C-reactive proteins ( CRP ) and the liver and kidney functional measures were longitudinally analyzed . RESULTS Patients in the EEN/rhubarb group had the shortest period of abdominal pain and the fastest recovery from abnormal bowel movement and high fever as well as significantly shorter periods of intensive-care unit and hospital stays . The combination of EEN and rhubarb significantly reduced the values of APACHE II scores . Combination therapies significantly reduced abnormally higher white blood cell ( WBC ) counts and levels of plasma CRP and IL-6 , but increased the levels of plasma IL-11 . Finally , combination therapies improved the SAP-related damages of liver and kidney function by reducing abnormally higher levels of plasma alanine aminotransferase , aspartate aminotransferase , and creatinine ( Cr ) . CONCLUSION Combination of EEN and rhubarb significantly improved the gastrointestinal function , inhibited systemic inflammation and disease severity and mitigated the disease-related damages of liver and kidney function in SAP patients .
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Intervention_Pharmacological
rhubarb
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Intervention_Pharmacological
early enteral nutrition
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Intervention_Pharmacological
rhubarb combined with early enteral nutrition ( EEN )
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Intervention_Pharmacological
EN suspension
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Intervention_Pharmacological
EEN combined with rhubarb group
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Intervention_Pharmacological
rhubarb and then EN 2 h later
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Intervention_Pharmacological
EEN/rhubarb
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Intervention_Pharmacological
EEN and rhubarb
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Intervention_Pharmacological
EEN and rhubarb
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Outcome_Physical
gastrointestinal function
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Outcome_Other
APACHE II scores
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Outcome_Physical
the levels of plasma IL-6 , IL-11
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Outcome_Physical
C-reactive proteins ( CRP )
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Outcome_Physical
the liver and kidney functional measures
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Outcome_Pain
period of abdominal pain and the fastest recovery from abnormal bowel movement and high fever
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Outcome_Other
APACHE II scores
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Outcome_Physical
white blood cell ( WBC ) counts
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Outcome_Physical
levels of plasma CRP
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Outcome_Physical
IL-6
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Outcome_Physical
levels of plasma IL-11
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Outcome_Physical
liver and kidney function
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Outcome_Physical
levels of plasma alanine aminotransferase
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Outcome_Physical
aspartate aminotransferase
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Outcome_Physical
creatinine ( Cr )
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Participant_Condition
patients with severe acute pancreatitis ( SAP )
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Participant_Sample-size
126 patients
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Participant_Condition
SAP
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Participant_Condition
SAP