38664
document
Effect of testosterone and a nutritional supplement , alone and in combination , on hospital admissions in undernourished older men and women . BACKGROUND In older people , undernutrition is associated with increased hospitalization rates and mortality . Because weight loss in older people often reflects a disproportionate reduction of skeletal muscle , anabolic treatments may be beneficial . OBJECTIVE Our aim was to evaluate the hypothesis that testosterone treatment and a nutritional supplement have additive benefits . DESIGN Oral testosterone undecanoate ( 40 mg daily for women , 80 mg twice daily for men ) and an oral nutritional supplement ( 475 kcal/d ) were administered , alone or combined , for 1 y to 49 community-dwelling , undernourished people [ Mini Nutritional Assessment score < 24 and low body weight ( body mass index , in kg/m ( 2 ) : < 22 ) or recent weight loss ( > 7.5 % over 3 mo ) ] aged > 65 y ( mean age : 77 y ; 26 women and 23 men ) . Hospital admissions and other variables were assessed . RESULTS In subjects receiving combined testosterone and nutritional supplements ( n = 11 ) , there were no hospital admissions , whereas there were 9 admissions ( 2 elective ) in 13 subjects in the no-treatment group , 4 in the testosterone-treated group ( n = 12 ) , and 5 in the supplement-treated group ( n = 13 ) ; P = 0.06 with no-treatment compared with combined treatment . When compared with the no-treatment group , the combined-treatment group had significantly fewer subjects admitted to hospital ( 0 compared with 5 , P = 0.03 ) , fewer days in hospital ( 0 compared with 74 , P = 0.041 ) , and a longer time to hospital admission ( P = 0.017 ) . CONCLUSIONS In undernourished older people , combined treatment with testosterone and nutritional supplementation reduced the number of people hospitalized and the duration of hospital admissions , which are important endpoints in this group . Larger , confirmatory studies are now needed . This trial was registered before commencement at clinical trials.gov as NCT00117000 .
38665
Intervention_Pharmacological
testosterone
38666
Intervention_Pharmacological
nutritional supplement
38667
Intervention_Other
in combination
38668
Intervention_Pharmacological
testosterone treatment
38669
Intervention_Pharmacological
nutritional supplement
38670
Intervention_Pharmacological
Oral testosterone undecanoate
38671
Intervention_Pharmacological
oral nutritional supplement
38672
Intervention_Control
alone
38673
Intervention_Control
combined
38674
Intervention_Pharmacological
combined testosterone
38675
Intervention_Pharmacological
nutritional supplements
38676
Intervention_Control
no-treatment
38677
Intervention_Pharmacological
testosterone-treated
38678
Intervention_Pharmacological
supplement-treated
38679
Intervention_Control
no-treatment
38680
Intervention_Control
combined-treatment
38681
Intervention_Pharmacological
testosterone
38682
Intervention_Pharmacological
nutritional supplementation
38683
Outcome_Other
hospital admissions
38684
Outcome_Other
hospitalization rates
38685
Outcome_Mortality
mortality
38686
Outcome_Other
Hospital admissions
38687
Outcome_Other
other variables
38688
Outcome_Other
hospital admissions
38689
Outcome_Other
subjects admitted to hospital
38690
Outcome_Other
days in hospital
38691
Participant_Condition
undernourished
38692
Participant_Age
older
38693
Participant_Sex
men and women
38694
Participant_Condition
community-dwelling
38695
Participant_Condition
undernourished people
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Participant_Condition
Mini Nutritional Assessment score < 24 and low body weight ( body mass index , in kg/m ( 2 ) : < 22 ) or recent weight loss ( > 7.5 % over 3 mo
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Participant_Age
aged > 65 y ( mean age : 77 y ;
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Participant_Sex
26 women and 23 men
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Participant_Age
older