12065
document
Bioavailability of omega-3 essential fatty acids from perilla seed oil . Increased dietary intake of fish oil omega-3 fatty acids , eicosapentanoic acid and docosohexanoic acid , and their precursor , alpha-linolenic acid ( ALA ) , is associated with various health benefits . Enteric-coating ( Entrox ) , which improves stability of omega-3 capsules , has been shown to facilitate fish oil absorption after chronic treatment . To assess the effect of Entrox coating on the short-term bioavailability of ALA administered in the form of ALA-rich Perilla seed oil , 12 healthy subjects ( 6 males and 6 females ) received in a random order Entrox-coated and non-coated ALA formulations , each as a single 6g dose separated by a 3-week washout period . Measurements of plasma ALA concentrations from 0 to 24h showed no difference in ALA pharmacokinetics between the two formulations . However , significantly greater increases in plasma ALA levels from baseline to 24h were observed after ingestion of Entrox vs. non-coated product , suggesting a possible benefit of Entrox with long-term treatment .
12066
Intervention_Pharmacological
omega-3 essential fatty acids
12067
Intervention_Pharmacological
perilla seed oil
12068
Intervention_Pharmacological
fish oil omega-3 fatty acids
12069
Intervention_Pharmacological
alpha-linolenic acid
12070
Intervention_Pharmacological
ALA
12071
Intervention_Pharmacological
Entrox-coated and non-coated ALA formulations
12072
Outcome_Other
Bioavailability
12073
Outcome_Other
plasma ALA concentrations
12074
Outcome_Physical
plasma ALA levels
12075
Participant_Condition
omega-3 essential fatty acids from perilla seed oil .
12076
Participant_Condition
12 healthy subjects ( 6 males and 6 females )