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document
Antipyretic efficacy of ibuprofen vs acetaminophen . OBJECTIVE To compare the antipyretic efficacy of ibuprofen , placebo , and acetaminophen . DESIGN Double-dummy , double-blind , randomized , placebo-controlled trial . SETTING Emergency department and inpatient units of a large , metropolitan , university-based , children 's hospital in Michigan . PARTICIPANTS 37 otherwise healthy children aged 2 to 12 years with acute , intercurrent , febrile illness . INTERVENTIONS Each child was randomly assigned to receive a single dose of acetaminophen ( 10 mg/kg ) , ibuprofen ( 7.5 or 10 mg/kg ) , or placebo . MEASUREMENTS/MAIN RESULTS Oral temperature was measured before dosing , 30 minutes after dosing , and hourly thereafter for 8 hours after the dose . Patients were monitored for adverse effects during the study and 24 hours after administration of the assigned drug . All three active treatments produced significant antipyresis compared with placebo . Ibuprofen provided greater temperature decrement and longer duration of antipyresis than acetaminophen when the two drugs were administered in approximately equal doses . No adverse effects were observed in any treatment group . CONCLUSION Ibuprofen is a potent antipyretic agent and is a safe alternative for the selected febrile child who may benefit from antipyretic medication but who either can not take or does not achieve satisfactory antipyresis with acetaminophen .
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Intervention_Pharmacological
ibuprofen
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Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
ibuprofen , placebo
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Intervention_Pharmacological
acetaminophen
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
ibuprofen
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
Ibuprofen
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Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
Ibuprofen
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Intervention_Pharmacological
acetaminophen
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Outcome_Physical
Antipyretic efficacy
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Outcome_Other
antipyretic efficacy
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Outcome_Physical
Oral temperature
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Outcome_Adverse-effects
adverse effects
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Outcome_Physical
antipyresis
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Outcome_Physical
temperature decrement
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Outcome_Physical
duration of antipyresis
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Outcome_Adverse-effects
adverse effects
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Outcome_Physical
antipyretic
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Outcome_Physical
safe
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Outcome_Physical
antipyresis
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Participant_Condition
metropolitan , university-based , children 's hospital in Michigan .
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Participant_Sample-size
37
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Participant_Condition
otherwise healthy
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Participant_Age
children aged 2 to 12 years with
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Participant_Condition
acute , intercurrent , febrile illness
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Participant_Age
.
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Participant_Age
child