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document
The effect of treatment on pregnancy outcomes in women with one elevated oral glucose tolerance test value . OBJECTIVE The aim of the study was to evaluate whether dietary intervention could reduce maternal and perinatal morbidity in pregnancies with one elevated 100 g oral glucose tolerance test ( OGTT ) value . MATERIAL AND METHODS The study was conducted among patients with positive 50 g glucose challenge test ( GCT ) and one elevated 100 g OGTT value . Plasma glucose value of 140 mg/dL was used as the threshold to define an abnormal GCT result . Carpenter and Coustan criteria were used to evaluate the OGTT results . Seventy-four women with normal GCT values comprised group I. Ninety-nine women with one elevated 100 g OGTT value who were given a caloric diet and 102 women with one elevated OGTT value in group III who received antenatal care with no special diet were randomly assigned to groups II and III , respectively . All women were followed up until the end of pregnancy . Poor maternal outcome was defined as : cesarean delivery performed due to cephalopelvic disproportion , failure to progress or fetal distress , preeclampsia , and/or preterm labor . Poor perinatal outcome was defined as : small for gestational age , large for gestational age or admission to a neonatal intensive care unit . The groups were compared in terms of maternal and perinatal outcomes . RESULTS The rates of macrosomia and large for gestational age incidence were significantly higher in group III as compared to groups I and II . When we examined the multivariate effects of the risk factors considered to be predictive of poor maternal outcomes , group III was the only statistically significant risk factor ( OR=3.90 , 95 % CI:1.95- 7.84 ; p= < 0.001 ) . In terms of poor perinatal outcome , one elevated OGTT value ( group III ) was the only significant risk factor ( OR=2.92 , 95 % CI:1.56-5.46 ; p= < 0.001 ) . CONCLUSION Women with one elevated OGTT value benefit from a structured program of diet therapy aimed to reduce adverse maternal and perinatal outcomes .
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Intervention_Physical
dietary intervention
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Intervention_Physical
caloric diet
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Intervention_Physical
antenatal care with no special diet
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Intervention_Physical
diet therapy
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Participant_Sex
women
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Participant_Condition
elevated oral glucose tolerance test value
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Participant_Condition
patients with positive 50 g glucose challenge test ( GCT )
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Participant_Condition
one elevated 100 g OGTT value
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Participant_Sample-size
Seventy-four
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Participant_Sex
women
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Participant_Sample-size
Ninety-nine
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Participant_Sex
women
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Participant_Sample-size
102
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Participant_Sex
women
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Participant_Sex
women
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Participant_Sex
Women