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document
Effect of carbon monoxide on exercise performance in chronic obstructive pulmonary disease . We evaluated the effect of breathing 100 ppm of carbon monoxide versus compressed , purified air for 1 hour on exercise performance in 10 patients with chronic obstructive pulmonary disease in a double-blind , randomized , crossover study . The mean arterial carboxyhemoglobin was 1.48 per cent in the carbon monoxide control period and increased from 1.43 to 4.08 per cent after breathing carbon monoxide ( P less than 0.001 ) . The mean arterial carboxyhemoglobin level was 1.52 percent in the air control period and decreased from 1.47 to 1.34 per cent after purified air ( P less than 0.001 ) . The mean exercise time until marked dyspnea decreased from 218.5 seconds in the carbon monoxide control period to 146.6 seconds after breathing carbon monoxide ( P less than 0.001 ) . The mean exercise time was 219.9 seconds in the air control period and 221.3 seconds after purified air ( P not significant ) . Breathing 100 ppm of carbon monoxide for 1 hour caused a significant reduction in exercise performance in patients with chronic obstructive pulmonary disease .
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Intervention_Pharmacological
carbon monoxide
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Intervention_Pharmacological
breathing 100 ppm of carbon monoxide
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Intervention_Pharmacological
compressed , purified air
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Intervention_Pharmacological
carbon monoxide
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Outcome_Physical
exercise performance
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Outcome_Physical
mean arterial carboxyhemoglobin
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Outcome_Physical
mean arterial carboxyhemoglobin level
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Outcome_Physical
mean exercise time until marked dyspnea
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Participant_Condition
chronic obstructive pulmonary disease
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Participant_Sample-size
10
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Participant_Condition
chronic obstructive pulmonary disease
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Participant_Condition
chronic obstructive pulmonary disease