61977
document
Comparative study for the effect of photodynamic therapy , imiquimod immunotherapy and combination of both therapies on 40 lesions of actinic keratosis in Japanese patients . We treated 12 , 15 and 13 Japanese actinic keratosis ( AK ) lesions with 5-aminolevulinic acid photodynamic therapy ( PDT ) , 5 % imiquimod cream and combination of both therapies , respectively , and compared the effects . Patients underwent the second course , when AK lesions remained after the first course . Efficacy was evaluated 1 month after each treatment . Combination therapy cleared all AK lesions only after the first course , while PDT and imiquimod therapy cleared 41.7 % and 66.7 % of AK lesions after the first course , respectively . All residual AK lesions after the first course were cleared by the second courses of PDT or imiquimod therapy . During the course , erosion and crust developed significantly more frequently in combination therapy ( P < 0.001 ) . Most Japanese AK lesions can be satisfactorily treated with either PDT or imiquimod monotherapy . However , only severe cases may better be treated with combination therapy , which show higher efficacy even though adverse events occur frequently .
61978
Intervention_Physical
photodynamic therapy
61979
Intervention_Pharmacological
imiquimod immunotherapy
61980
Intervention_Pharmacological
combination of both therapies
61981
Intervention_Physical
5-aminolevulinic acid photodynamic therapy ( PDT )
61982
Intervention_Pharmacological
5 % imiquimod cream
61983
Intervention_Pharmacological
combination of both therapies
61984
Outcome_Other
Efficacy
61985
Participant_Condition
actinic keratosis
61986
Participant_Condition
actinic keratosis ( AK )