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document
Effect of entacapone , a peripherally acting catechol-O-methyltransferase inhibitor , on the motor response to acute treatment with levodopa in patients with Parkinson 's disease . Catechol-O-methyltransferase ( COMT ) inhibitors may be useful in the treatment of Parkinson 's disease by improving the bioavailability of levodopa and by prolonging its effects . Entacapone ( OR-611 ) , a novel COMT inhibitor , which does not cross the blood brain barrier , was assessed in 12 patients with Parkinson 's disease and motor fluctuations in a randomised , double-blind , cross-over , single dose study . The magnitude and duration of the therapeutic response to a single dose of 200 mg levodopa/50 mg carbidopa was evaluated after concomitant placebo , or 200 or 800 mg entacapone . A significant increase in the duration of the motor response to levodopa was seen when 200 mg entacapone was given with levodopa/carbidopa . Plasma levodopa concentrations were increased with both doses of the COMT inhibitor . The latency to onset of motor response did not differ significantly between active drug and placebo . Entacapone may prove useful in prolonging the duration of the benefit obtained from individual doses of levodopa .
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Intervention_Pharmacological
entacapone
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Intervention_Pharmacological
Entacapone ( OR-611 )
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Intervention_Pharmacological
novel COMT inhibitor
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Intervention_Pharmacological
levodopa/50
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Intervention_Pharmacological
carbidopa
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Intervention_Control
placebo
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Intervention_Pharmacological
entacapone
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Outcome_Physical
motor response to acute treatment with levodopa
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Outcome_Other
bioavailability
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Outcome_Other
duration of the motor response
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Outcome_Physical
to levodopa
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Outcome_Other
Plasma levodopa concentrations
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Outcome_Physical
latency to onset of motor response
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Outcome_Other
prolonging the duration of the benefit
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Participant_Condition
Parkinson 's disease
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Participant_Condition
Parkinson 's disease
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Participant_Condition
motor fluctuations