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document
Neuropsychological effects of risperidone in children with pervasive developmental disorders : a blinded discontinuation study . OBJECTIVE Little is known about the neuropsychological effects of risperidone in children with pervasive developmental disorders . METHOD Twenty-four children ( aged 5-17 years ) with pervasive developmental disorders and co-morbid disruptive behavior who responded favorably to open-label treatment with risperidone as part of a previously described controlled discontinuation study completed two different computerized attention tasks at baseline , weeks 4 , 8 , and 24 of open-label treatment , and , at 8 weeks after random assignment to either placebo or risperidone . The primary efficacy measures were response latencies to visually presented stimuli requiring two different types of attention-controlled processing , i.e. , focused and divided attention . RESULTS About half of the clinical responders did not produce valid performance measures . These could be shown to be of younger mental age and less adaptive as measured by the Vineland Behavior Scales . For the valid task performers divided attention ( serial search in working memory ) was shown to regress in the placebo group ( n = 7 ) , while in the risperidone group ( n = 7 ) there was further improvement . No such group difference was found for focused attention . CONCLUSIONS The study suggests a beneficial effect of risperidone after several months of treatment , enhancing divided attention in children with pervasive developmental disorders .
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Intervention_Pharmacological
risperidone
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Intervention_Pharmacological
risperidone
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Intervention_Pharmacological
risperidone
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Intervention_Control
placebo
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Intervention_Pharmacological
risperidone
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Intervention_Pharmacological
risperidone
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Outcome_Mental
response latencies
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Outcome_Mental
attention-controlled processing , i.e.
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Outcome_Mental
focused and divided attention
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Outcome_Mental
valid performance measures
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Outcome_Mental
Vineland Behavior Scales
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Outcome_Mental
serial search in working memory
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Participant_Age
children
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Participant_Condition
pervasive developmental disorders
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Participant_Condition
pervasive developmental disorders
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Participant_Sample-size
Twenty-four children
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Participant_Age
aged 5-17 years