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document
Serotonergic control of TSH and PRL secretion in obese men . To evaluate whether the inhibitory control of TSH and the stimulatory control of prolactin ( PRL ) secretion exerted by endogenous serotonin was altered in obesity , 22 obese men and 10 normal controls were tested with TRH ( 200 micrograms IV bolus ) in the presence ( experimental test ) and absence ( control test ) of the serotonergic agonist fenfluramine ( 60 mg PO 90 min before TRH ) . Control and experimental tests were also performed in seven male patients with subclinical hypothyroidism and were repeated in the same obese subjects after substantial weight loss . Basal TSH levels were similar in control and obese men . Normal TSH responses to TRH ( peak less than or equal to 14 mU/L ) were observed in all normal controls ( mean peak +/- SE 9.8 +/- 0.6 mU/L ) . In contrast , obese men were divided into two groups : nine in whom the TRH-induced TSH rise was higher than normal ( group I : mean peak = 16.5 +/- 0.5 mU/L ) and 13 in whom it was normal ( group II : mean peak = 10.6 +/- 0.7 mU/L ) . The hypothyroid men all had elevated basal and TRH-stimulated TSH levels . Basal PRL concentrations were similar in the normal controls and both groups of obese subjects . The PRL response to TRH was lower in both group I and group II obese men than in normal controls and was similar between group I and group II . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
TRH
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Intervention_Pharmacological
serotonergic agonist fenfluramine
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Outcome_Physical
TSH
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Outcome_Physical
PRL secretion
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Outcome_Physical
TSH
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Outcome_Physical
stimulatory control of prolactin ( PRL ) secretion
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Outcome_Physical
Basal TSH levels
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Outcome_Physical
Normal TSH responses
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Outcome_Physical
TRH-induced TSH rise
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Outcome_Physical
basal and TRH-stimulated TSH levels
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Outcome_Physical
Basal PRL concentrations
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Participant_Condition
obese
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Participant_Sex
men
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Participant_Sample-size
22
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Participant_Condition
obese
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Participant_Sex
men
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Participant_Sample-size
10
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Participant_Condition
normal
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Participant_Sample-size
seven
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Participant_Condition
subclinical hypothyroidism
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Participant_Condition
obese
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Participant_Condition
obese
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Participant_Condition
obese
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Participant_Condition
hypothyroid
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Participant_Condition
obese