61935
document
Comparison of meloxicam and a glucosamine-chondroitin supplement in management of feline osteoarthritis . A double-blind randomised , placebo-controlled , prospective trial . OBJECTIVE To compare the efficacy of meloxicam and a glucosamine-chondroitin ( Glu-Ch ) supplement in the management of feline osteoarthritis ( OA ) . METHODS Prospective , blinded , randomized clinical trial . Cats over eight years of age with clinical signs of chronic OA were assigned to one of two groups and Glu-Ch or meloxicam was administered orally for 70 days , followed by a placebo until day 98 . Cats were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time . RESULTS Data were collected from thirty cats . Pre-treatment disease scores were significantly higher in the meloxicam group for owner mobility ( p=0.01 ) and veterinary lameness ( p=0.02 ) . Owner mobility scores at day 14 ( p=0.01 ) and day 42 ( p=0.002 ) were significantly improved compared to pre-treatment scores for the meloxicam group . When meloxicam and Glu-Ch were discontinued and the placebo commenced , a significant proportion of the meloxicam group showed worsening of all the owner-assessed scores between day 70 and day 98 , when compared to the Glu-Ch group ( mobility p=0.01 ; activity p=0.02 ; temperament p=0.04 ; lifestyle p=0.01 ) . CONCLUSIONS Treatment with meloxicam resulted in a significant improvement in mobility and activity levels of cats with OA until the placebo was introduced . A greater proportion of cats receiving meloxicam medication showed a significant worsening of owner assessment scores once the placed was introduced , when compared to the Glu-Ch group .
61936
Intervention_Pharmacological
meloxicam
61937
Intervention_Pharmacological
glucosamine-chondroitin supplement
61938
Intervention_Pharmacological
meloxicam
61939
Intervention_Pharmacological
glucosamine-chondroitin ( Glu-Ch ) supplement
61940
Intervention_Pharmacological
Glu-Ch or meloxicam
61941
Intervention_Control
placebo
61942
Intervention_Pharmacological
meloxicam
61943
Intervention_Pharmacological
meloxicam
61944
Intervention_Pharmacological
meloxicam
61945
Intervention_Pharmacological
meloxicam
61946
Intervention_Pharmacological
meloxicam
61947
Intervention_Pharmacological
meloxicam
61948
Outcome_Physical
feline osteoarthritis .
61949
Outcome_Physical
feline osteoarthritis ( OA )
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Outcome_Physical
owner mobility
61951
Outcome_Physical
veterinary lameness
61952
Outcome_Physical
Owner mobility scores
61953
Outcome_Physical
mobility
61954
Outcome_Physical
activity levels
61955
Participant_Condition
feline osteoarthritis
61956
Participant_Condition
feline osteoarthritis ( OA )
61957
Participant_Age
Cats over eight years of age
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Participant_Condition
clinical signs of chronic OA