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document
Effects of insufficient sleep on blood pressure in hypertensive patients : a 24-h study . The influence of acute sleep deprivation during the first part of the night on 24-h blood pressure monitoring ( ABPM ) was studied in 36 never-treated mild to moderate hypertensive patients . According to a crossover design , they were randomized to have either sleep deprivation or a full night 's sleep 1 week apart , during which they were monitored with ABPM . Urine samples for analysis of nocturnal urinary excretion of norepinephrine were collected . During the sleep-deprivation day , both mean 24-h blood pressure and mean 24-h heart rate were higher in comparison with those recorded during the routine workday , the difference being more pronounced during the nighttime ( P < .01 ) . Urinary excretion of norepinephrine showed a significant increase at night during sleep deprivation ( P < .05 ) . Blood pressure and heart rate significantly increased in the morning after a sleep-insufficient night ( P < .05 ) . These data suggest that lack of sleep in hypertensive patients may increase sympathetic nervous activity during the night and the following morning , leading to increased blood pressure and heart rate . This situation might represent an increased risk for both target organ damage and acute cardiovascular diseases .
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Intervention_Physical
insufficient sleep
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Intervention_Physical
24-h blood pressure monitoring
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Intervention_Physical
sleep deprivation
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Intervention_Physical
full night 's sleep
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Intervention_Physical
sleep-deprivation
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Intervention_Physical
sleep deprivation
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Intervention_Physical
sleep-insufficient
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Outcome_Physical
blood pressure
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Outcome_Physical
blood pressure
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Outcome_Physical
excretion of norepinephrine
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Outcome_Physical
blood pressure
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Outcome_Physical
Urinary excretion of norepinephrine
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Outcome_Physical
Blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
sympathetic nervous activity
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
risk for both target organ damage and acute cardiovascular diseases
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Participant_Condition
hypertensive patients :
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Participant_Condition
36 never-treated mild to moderate hypertensive patients .