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A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers . OBJECTIVE Ibuprofen arginate is a salt formulation of ibuprofen designed to reach target concentrations rapidly . The primary objective of this study was to compare the 12-h pharmacokinetic profile of S ( + ) -ibuprofen following administration of single doses of ibuprofen arginate ( 600 mg ) and dexibuprofen ( 400 mg ) in healthy volunteers . METHODS Twenty-four volunteers were recruited into an open-label , randomised , two-period , single-centre study with crossover design . RESULTS Both treatments were well tolerated . Ibuprofen arginate and dexibuprofen showed similar bioavailability for S ( + ) -ibuprofen . Compared with dexibuprofen , ibuprofen arginate demonstrated a 45 % higher maximum concentration ( C ( max ) ) , and a time to peak concentration ( T ( max ) ) 2 h sooner . CONCLUSION Ibuprofen arginate approaches maximum concentrations of S ( + ) -ibuprofen faster and higher than dexibuprofen .
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Intervention_Pharmacological
ibuprofen arginate
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Intervention_Pharmacological
dexibuprofen
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Intervention_Pharmacological
Ibuprofen arginate
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Intervention_Pharmacological
ibuprofen
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Intervention_Pharmacological
S ( + ) -ibuprofen
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Intervention_Pharmacological
ibuprofen arginate
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Intervention_Pharmacological
dexibuprofen
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Intervention_Pharmacological
Ibuprofen arginate
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Intervention_Pharmacological
dexibuprofen
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Intervention_Pharmacological
S ( + ) -ibuprofen
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Intervention_Pharmacological
dexibuprofen
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Intervention_Pharmacological
ibuprofen arginate
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Intervention_Pharmacological
Ibuprofen arginate
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Intervention_Pharmacological
dexibuprofen
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Outcome_Other
comparative study of the pharmacokinetics
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Outcome_Other
pharmacokinetic profile
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Outcome_Other
bioavailability for S ( + ) -ibuprofen
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Outcome_Other
maximum concentration ( C ( max ) )
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Outcome_Other
time to peak concentration ( T ( max ) )