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document
[ Local therapy of grade 1 and 2 hemorrhoids . Effectiveness of a combination preparation with standardized blood leech extract ] . AIMS Testing the effectiveness of a topical combination preparation containing standardized leech extract , polidocanol and allantoin . STUDY DESIGN Placebo-controlled , double-blind study in 80 patients with first and second degree hemorrhoids ; duration of treatment one week ; examinations performed on admission and on days 3 , 4 , 5 and 8 . RESULTS Both the subjective and objective symptoms and signs improved during the one week of treatment statistically significantly more rapidly under the test preparation as compared with placebo . Histologically demonstrable signs of inflammation were more clearly improved in the preparation group than in the placebo group . No side effects were observed . CONCLUSIONS The good efficacy and tolerability of a topical therapeutic preparation in first and second degree hemorrhoids have been convincingly demonstrated .
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Intervention_Physical
[ Local therapy of grade 1 and 2 hemorrhoids .
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Intervention_Pharmacological
combination preparation with standardized blood leech extract ]
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Intervention_Pharmacological
topical combination preparation containing standardized leech extract , polidocanol and allantoin .
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Intervention_Control
Placebo-controlled
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Intervention_Educational
test preparation
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Intervention_Physical
topical therapeutic preparation
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Outcome_Physical
subjective and objective symptoms and signs improved
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Outcome_Physical
Histologically demonstrable signs of inflammation
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Outcome_Adverse-effects
No side effects
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Participant_Condition
grade 1
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Participant_Condition
2 hemorrhoids
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Participant_Sample-size
80
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Participant_Condition
first and second degree hemorrhoids