44994
document
Efficacy and safety of a high protein , low carbohydrate diet for weight loss in severely obese adolescents . OBJECTIVE To evaluate the efficacy and safety of a carbohydrate restricted versus a low fat diet on weight loss , metabolic markers , body composition , and cardiac function tests in severely obese adolescents . STUDY DESIGN Subjects were randomly assigned to 1 of 2 diets : a high protein , low carbohydrate ( 20 g/d ) diet ( high protein , low carbohydrate , HPLC ) or low fat ( 30 % of calories ) regimen for 13 weeks ; close monitoring was maintained to evaluate safety . After the intervention , no clinical contact was made until follow-up measurements were obtained at 24 and 36 weeks from baseline . The primary outcome was change in body mass index Z-score for age and sex ( BMI-Z ) at 13 , 24 , and 36 weeks . RESULTS Forty-six subjects ( 24 HPLC , 22 in low fat ) initiated and 33 subjects completed the intervention ; follow-up data were available on approximately half of the subjects . Significant reduction in ( BMI-Z ) was achieved in both groups during intervention and was significantly greater for the HPLC group ( P = .03 ) . Both groups maintained significant BMI-Z reduction at follow-up ; changes were not significantly different between groups . Loss of lean body mass was not spared in the HPLC group . No serious adverse effects were observed related to metabolic profiles , cardiac function , or subjective complaints . CONCLUSIONS The HPLC diet is a safe and effective option for medically supervised weight loss in severely obese adolescents .
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Intervention_Other
high protein , low carbohydrate diet
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Intervention_Pharmacological
carbohydrate restricted versus a low fat diet
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Intervention_Other
high protein , low carbohydrate ( 20 g/d ) diet ( high protein , low carbohydrate , HPLC )
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Intervention_Physical
low fat ( 30 % of calories ) regimen
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Intervention_Pharmacological
HPLC
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Outcome_Physical
weight loss
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Outcome_Physical
metabolic markers
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Outcome_Physical
body composition
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Outcome_Physical
cardiac function tests
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Outcome_Physical
change in body mass index Z-score
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Outcome_Physical
BMI-Z
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Outcome_Physical
BMI-Z
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Outcome_Physical
BMI-Z reduction
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Outcome_Physical
lean body mass
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Outcome_Adverse-effects
serious adverse effects
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Outcome_Physical
metabolic profiles
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Outcome_Physical
cardiac function
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Participant_Age
severely obese adolescents .
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Participant_Age
severely obese adolescents .
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Participant_Sample-size
Forty-six
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Participant_Sample-size
24
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Participant_Sample-size
22
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Participant_Sample-size
33
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Participant_Age
severely obese adolescents .