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document
Outcomes and biochemical parameters following cardiac surgery : effects of transfusion of residual blood using centrifugation and multiple-pass hemoconcentration . OBJECTIVES To determine whether or not there was a significant difference between the methods of centrifugation ( CF ) and multiple-pass hemoconcentration ( MPH ) of the residual cardiopulmonary-bypass volume in relation to biochemical measurements and patient outcomes . DESIGN Prospective , randomized , and controlled . SETTING Conducted at a western Canadian tertiary care hospital . PARTICIPANTS Consisted of 61 consecutive male and female patients from ages 40 to 80 who were scheduled for cardiac surgery with cardiopulmonary bypass . INTERVENTIONS Either the centrifugation or multiple-pass hemoconcentration method was used to process the residual blood from the cardiopulmonary bypass circuit . RESULTS The 12-hour postoperative levels of serum hemoglobin were not significantly different in the centrifugation group as compared to the multiple-pass hemoconcentration group . However , the serum levels of total protein and albumin were significantly higher in the multiple-pass hemoconcentration group as compared to the centrifugation group . Additionally , after 12-hours postoperatively , the serum fibrinogen and platelet counts were significantly higher in the multiple-pass hemoconcentration group as compared to those of the centrifugation group . The allogeneic product transfusion index and the chest-tube blood drainage indices were lower in the multiple-pass hemoconcentration group as compared to the centrifugation group . CONCLUSION Although the CF method provided a product in a shorter turnaround time , with consistent clearance of heparin , the MPH method trended towards enhanced biochemical and clinical patient outcomes over the 12-hour postoperative period .
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Intervention_Surgical
cardiac surgery :
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Intervention_Physical
transfusion of residual blood
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Intervention_Physical
centrifugation and multiple-pass hemoconcentration .
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Intervention_Surgical
cardiac surgery
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Intervention_Surgical
cardiopulmonary bypass .
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Intervention_Physical
centrifugation or multiple-pass hemoconcentration method
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Intervention_Physical
centrifugation
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Intervention_Physical
multiple-pass hemoconcentration
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Intervention_Physical
multiple-pass hemoconcentration
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Intervention_Physical
centrifugation
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Intervention_Physical
multiple-pass hemoconcentration
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Intervention_Physical
centrifugation
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Intervention_Physical
multiple-pass hemoconcentration
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Intervention_Physical
centrifugation
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Intervention_Physical
CF method
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Intervention_Physical
MPH method
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Outcome_Physical
12-hour postoperative levels of serum hemoglobin
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Outcome_Physical
serum levels of total protein and albumin
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Outcome_Physical
serum fibrinogen
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Outcome_Physical
platelet counts
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Outcome_Physical
allogeneic product transfusion index
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Outcome_Physical
chest-tube blood drainage indices
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Outcome_Other
enhanced biochemical and clinical patient outcomes
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Participant_Condition
cardiac surgery
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Participant_Sample-size
61
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Participant_Sex
male
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Participant_Sex
female
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Participant_Age
ages 40 to 80
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Participant_Condition
scheduled for cardiac surgery with cardiopulmonary bypass