91760
document
Scintigraphic evaluation of a new capsule-type colon specific drug delivery system in healthy volunteers . Colonic drug delivery is intended for local or systemic therapies . The lack of predictive in vitro or animal model leads to considerable time delays in colonic product development . The objective of this scintigraphic study was to provide " proof of concept " for a novel capsule-type colonic delivery system ( Colon-Targeted Delivery Capsule ) in healthy volunteers . The human data validates the design concept behind the release mechanism , in that capsule disintegration , and hence drug release , did not start until 5 h after gastric emptying , irrespective of whether the product was administered to fasted or fed subjects . However , the potential for prolonged gastric residence for large enteric coated products intended for intestinal targeting was also observed ; overall , the study provides a focus for subsequent product development and highlights the role of scintigraphy in dynamically visualizing the drug delivery process .
91761
Intervention_Pharmacological
new capsule-type colon specific drug delivery system
91762
Intervention_Physical
Colonic drug delivery
91763
Intervention_Physical
novel capsule-type colonic delivery system ( Colon-Targeted Delivery Capsule )
91764
Participant_Condition
healthy volunteers .