79591
document
A comparison of the serologic responses to oral and injectable trivalent poliovirus vaccines . United States children two months of age were randomly assigned to two groups that received either the commercially available oral trivalent poliovirus vaccine ( OPV ) or an injectable ( inactivated ) trivalent poliovirus vaccine ( IPV ) with a confirmed minimum D-antigen content of 27 , 3.5 , and 29 units for poliovirus types 1 , 2 , and 3 , respectively . Vaccine was given at two , four , and 18 months of age . Sera obtained from 439 children at two , four , and six months of age and from 85 children at 18 and 20 months of age were examined for neutralizing antibodies . The percentage of children with detectable antibodies and the reciprocal geometric mean titers were similar for both groups at two months of age for antibodies to all three poliovirus types . At 20 months of age , all children but one had detectable antibodies to all three poliovirus types . Significantly higher geometric mean titers against types 2 and 3 were noted at 20 months of age for the IPV group .
79592
Intervention_Pharmacological
trivalent poliovirus vaccines
79593
Intervention_Pharmacological
oral trivalent poliovirus vaccine ( OPV )
79594
Intervention_Pharmacological
injectable ( inactivated ) trivalent poliovirus vaccine ( IPV )
79595
Intervention_Pharmacological
IPV
79596
Outcome_Physical
neutralizing antibodies
79597
Outcome_Physical
percentage of children with detectable antibodies and the reciprocal geometric mean titers
79598
Outcome_Physical
geometric mean titers against types 2 and 3
79599
Participant_Age
children two months
79600
Participant_Sample-size
439
79601
Participant_Age
children at two , four , and six months of age
79602
Participant_Sample-size
85
79603
Participant_Age
children at 18 and 20 months of age