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document
Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation . OBJECTIVE This prospective randomized study aims at evaluation and comparison of the prophylactic effects of amiodarone versus digoxin and metoprolol combination in postcoronary bypass atrial fibrillation . METHODS A total of 241 consecutive patients undergoing elective coronary artery bypass grafting were randomly allocated into three groups . Patients in Group1 ( n=77 ) received metoprolol 100 mg/24 h per oral ( P.O . ) , preoperatively , 2x0.5 mg digoxin intravenously on the operating day and digoxin 0.25 mg P.O.+metoprolol 100 mg P.O . on the first postoperative day until discharge . Patients in Group 2 ( n=72 ) received totally 1200 mg intravenous/24 h amiodarone which the 300 mg - bolus dose/1 h was given as soon as the operation had been finished . On the next day patients were administered 450 mg/24 h amiodarone i.v . and 600 mg/day in three doses P.O . were given until discharge . Group 3 ( n=92 ) was the control group with no antiarrhythmic prophylaxis . RESULTS Preoperative patient characteristics and operative parameters were similar in three groups . Atrial fibrillation occurred in 13 patients ( 16.8 % ) in Group 1 , six patients ( 8.3 % ) in Group 2 and 31 patients ( 33.6 % ) in Group 3 . CONCLUSION Both study groups were effective in the prevention of postcoronary bypass atrial fibrillation with respect to control ( P < 0.01 in Group 1 and P < 0.001 in Group 2 ) .
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Intervention_Pharmacological
Amiodarone versus digoxin
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Intervention_Pharmacological
metoprolol combination
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Intervention_Pharmacological
amiodarone versus digoxin
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Intervention_Pharmacological
metoprolol combination
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Intervention_Pharmacological
metoprolol 100 mg/24 h per oral
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Intervention_Pharmacological
digoxin intravenously on the operating day
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Intervention_Pharmacological
digoxin 0.25 mg P.O.+metoprolol 100 mg P.O .
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Intervention_Pharmacological
amiodarone
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Intervention_Pharmacological
amiodarone
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Intervention_Control
control group
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Outcome_Physical
postcoronary bypass atrial fibrillation
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Outcome_Physical
postcoronary bypass atrial fibrillation
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Outcome_Physical
Atrial fibrillation
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Outcome_Physical
postcoronary bypass atrial fibrillation
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Participant_Sample-size
241
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Participant_Condition
elective coronary artery bypass grafting
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Participant_Sample-size
Group1 ( n=77 )
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Participant_Sample-size
Group 2 ( n=72 )
8456
Participant_Sample-size
Group 3 ( n=92 )