74488
document
Comparison of four continuously administered progestogen plus oestradiol combinations for climacteric complaints . Sixty women with climacteric complaints who had not menstruated for at least 1 year were randomly allocated to receive one of four hormonal replacement regimens . All four formulations were administered daily and continuously and each contained 2 mg of micronized oestradiol-17 beta in combination with either norethisterone acetate 1 mg ( group A ) or 0.5 mg ( group B ) or megestrol acetate 5 mg ( group C ) or 2.5 mg ( group D ) . The clinical efficacy was the same although the alleviation of vasomotor symptoms was somewhat slower in those women receiving preparation A . The endometrium was atrophied in nearly all biopsies . Irregular uterine bleeding was almost entirely confined to the earlier phase of the study and was substantially less with the formulation containing 1 mg norethisterone acetate . It is concluded that a continuous oestradiol-progestogen combination can be used for long-term treatment of climacteric complaints in postmenopausal women and that after 4 months the clinical efficacy is the same irrespective of the type and dose of progestogen administered .
74489
Intervention_Pharmacological
progestogen plus oestradiol
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Intervention_Pharmacological
micronized oestradiol-17 beta in combination with either norethisterone acetate 1 mg
74491
Intervention_Pharmacological
or megestrol acetate 5 mg
74492
Intervention_Pharmacological
norethisterone acetate
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Intervention_Pharmacological
oestradiol-progestogen combination
74494
Intervention_Pharmacological
progestogen
74495
Outcome_Other
climacteric complaints .
74496
Outcome_Other
clinical efficacy
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Outcome_Physical
vasomotor symptoms
74498
Outcome_Physical
endometrium
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Outcome_Physical
biopsies .
74500
Outcome_Other
Irregular
74501
Outcome_Physical
uterine
74502
Outcome_Other
bleeding
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Outcome_Physical
climacteric complaints
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Outcome_Physical
clinical efficacy
74505
Participant_Sample-size
Sixty
74506
Participant_Condition
not menstruated