83549
document
The effects of single oral doses of 17 beta-oestradiol and progesterone on finger skin circulation in healthy women and in women with primary Raynaud 's phenomenon . The effects of sex , the menstrual cycle , oral contraceptives , pregnancy , and the menopause on skin perfusion in healthy women and in patients with Raynaud 's phenomenon suggest a role of female sex hormones . However , no clear relation between skin blood flow and circulating concentrations of oestrogens or progestogens has yet been found . The aim of this study was to investigate the effect of orally administered 17 beta-oestradiol and progesterone on finger skin blood flow before and during heat and cold challenge in 17 healthy normotensive women and in 12 women with Raynaud 's phenomenon . In each subject standardized finger heating ( 45 degrees C water bath , 10 min ) and cooling tests ( 15 degrees C water bath , 5 min and 20 min recovery ) were performed twice on the second ( or third ) day of two consecutive menstrual cycles . 17 beta-Oestradiol ( 9 mg ) or progesterone ( 300 mg ) were given before the second test , after a first test with placebo . Both hormonal doses resulted in ( high ) physiological concentrations . Fingertip skin temperature and laser Doppler flux were measured . There were no significant differences in the test results after placebo and after progesterone . Although values of fingertip skin temperature and laser Doppler flux after 17 beta-oestradiol tended to be higher only the precooling values in the healthy subjects reached significance : fingertip skin temperature respectively with placebo and with oestradiol ( mean ( SD ) ) : 32.7 ( 1.0 ) and 33.1 ( 0.8 ) degrees C ; laser Doppler flux with placebo and with oestradiol : 33.6 ( 11.7 ) and 42.2 ( 9.5 ) perfusion units ; both P < 0.05 ) . ( ABSTRACT TRUNCATED AT 250 WORDS )
83550
Intervention_Pharmacological
17 beta-oestradiol
83551
Intervention_Pharmacological
progesterone
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Intervention_Pharmacological
17 beta-oestradiol
83553
Intervention_Pharmacological
progesterone
83554
Intervention_Pharmacological
17 beta-Oestradiol
83555
Intervention_Pharmacological
progesterone
83556
Intervention_Control
placebo
83557
Outcome_Physical
finger skin circulation
83558
Outcome_Physical
skin blood flow
83559
Outcome_Physical
finger skin blood flow
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Outcome_Physical
physiological concentrations
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Outcome_Physical
Fingertip skin temperature
83562
Outcome_Physical
laser Doppler flux
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Participant_Condition
healthy women and in women with primary Raynaud 's phenomenon .