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document
Effect of allopurinol on myocardial oxygen free radical production in coronary bypass surgery . OBJECTIVES Allopurinol protects the heart from reperfusion injury . The aim of this study was to investigate myocardial free radical production during reperfusion with and without allopurinol treatment in coronary artery bypass grafting patients randomized into allopurinol ( n = 14 ) or placebo ( n = 13 ) groups . DESIGN Allopurinol ( 1 g ) was given blind prior to cardiopulmonary bypass and prior to opening the aorta . Oxygen free radicals were measured before anesthesia in arterial blood , before cross-clamping and 1 and 10 min after reperfusion in arterial and coronary sinus blood . Levels were measured as relative concentrations by the electron spin resonance method . RESULTS One minute after reperfusion the level of spin-trapped radicals in arterial blood was elevated significantly ( p = 0.016 ) in the allopurinol group , from 7.7 ( SE : 0.8 ) to 8.6 ( 1.4 ) and non-significantly ( p = 0.074 ) in the placebo group , from 7.3 ( 0.7 ) to 8.3 ( 0.8 ) . Ten minutes after reperfusion the arterial values were 8.6 ( 1.5 ) in the allopurinol and 7.6 ( 0.7 ) in the placebo group , the sinus values being 7.6 ( 1.3 ) and 8.3 ( 0.8 ) , respectively . Myocardial free radical production was -0.94 ( 1.21 ) in the allopurinol and +0.79 ( 0.96 ) in the placebo group after 10 min reperfusion , the difference being significant ( p = 0.043 ) . CONCLUSIONS All patients in both groups had an increasing tendency to free radical production during early reperfusion . Patients treated with allopurinol showed less myocardial production of free radicals , indicating that its protective effect may be due to its antioxidative properties .
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Intervention_Pharmacological
allopurinol
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Intervention_Pharmacological
Allopurinol
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Intervention_Pharmacological
allopurinol
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Intervention_Control
placebo
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Intervention_Pharmacological
Allopurinol ( 1 g )
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Intervention_Educational
Levels were measured as relative concentrations by the electron spin resonance method
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Outcome_Physical
oxygen free radical production
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Outcome_Physical
myocardial free radical production
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Outcome_Physical
Oxygen free radicals
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Outcome_Physical
spin-trapped radicals in arterial blood
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Outcome_Physical
arterial values were
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Outcome_Physical
the sinus values
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Outcome_Physical
myocardial production of free radicals
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Participant_Condition
coronary artery bypass grafting
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Participant_Sample-size
14
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Participant_Sample-size
13