73092
document
Ultrasound is at least as good as magnetic resonance imaging in predicting tumour size post-neoadjuvant chemotherapy in breast cancer . BACKGROUND The aim of this study was to evaluate the accuracy of clinical imaging of the primary breast tumour post-neoadjuvant chemotherapy ( NAC ) related to the post-neoadjuvant histological tumour size ( gold standard ) and whether this varies with breast cancer subtype . In this study , results of both magnetic resonance imaging ( MRI ) and ultrasound ( US ) were reported . METHODS Patients with invasive breast cancer were enrolled in the INTENS study between 2006 and 2009 . We included 182 patients , of whom data were available for post-NAC MRI ( n=155 ) , US ( n=123 ) , and histopathological tumour size . RESULTS MRI estimated residual tumour size with < 10-mm discordance in 54 % of patients , overestimated size in 28 % and underestimated size in 18 % of patients . With US , this was 63 % , 20 % and 17 % , respectively . The negative predictive value in hormone receptor-positive tumours for both MRI and US was low , 26 % and 33 % , respectively . The median deviation in clinical tumour size as percentage of pathological tumour was 63 % ( P25=26 , P75=100 ) and 49 % ( P25=22 , P75=100 ) for MRI and US , respectively ( P=0.06 ) . CONCLUSIONS In this study , US was at least as good as breast MRI in providing information on residual tumour size post-neoadjuvant chemotherapy . However , both modalities suffered from a substantial percentage of over- and underestimation of tumour size and in addition both showed a low negative predictive value of pathologic complete remission ( Gov nr : NCT00314977 ) .
73093
Intervention_Physical
Ultrasound
73094
Intervention_Physical
magnetic resonance imaging
73095
Intervention_Physical
primary breast tumour post-neoadjuvant chemotherapy ( NAC )
73096
Intervention_Physical
magnetic resonance imaging ( MRI )
73097
Intervention_Physical
ultrasound ( US )
73098
Intervention_Physical
MRI
73099
Intervention_Physical
US
73100
Outcome_Physical
predicting tumour size
73101
Outcome_Other
accuracy
73102
Outcome_Physical
residual tumour size
73103
Outcome_Physical
median deviation in clinical tumour size as percentage of pathological tumour
73104
Outcome_Physical
negative predictive value of pathologic complete remission
73105
Participant_Condition
chemotherapy in breast cancer .
73106
Participant_Condition
breast cancer subtype .
73107
Participant_Condition
invasive breast cancer
73108
Participant_Sample-size
182 patients
73109
Participant_Condition
histopathological tumour size