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document
Combined modality therapy in advanced Hodgkin 's disease : a report on 218 patients with a median follow-up of eight years . BACKGROUND AND OBJECTIVE This study was designed to evaluate the efficacy and toxicity of monthly alternating ABVD/MOPP compared to ABVD/OPP regimens in patients with advanced stage Hodgkin 's disease ( HD ) , as well as in early stage patients with systemic symptoms and/or bulky disease . DESIGN AND METHODS 218 patients with previously untreated HD entered this study : 106 patients in arm A ( ABVD/MOPP ) and 112 in arm B ( ABVD/OPP ) . Patients received eight courses of one of the two regimens after stratification according to the stage . Patients in complete remission ( CR ) received 20 Gy to the involved field and 40 Gy to the spleen . The actuarial survival curves were performed according to Kaplan and Meier . RESULTS No statistically significant differences were observed between the two arms in terms of CR rate and toxicity . However , analysis of total relapses revealed that patients treated with ABVD/OPP had a significantly higher likelihood of achieving a second CR compared to patients who entered the ABVD/MOPP arm . INTERPRETATION AND CONCLUSIONS Both schemes of chemotherapy followed by radiotherapy produce high percentages of CR , low risk of relapse and an acceptable toxicity .
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Intervention_Physical
Combined modality therapy
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Intervention_Pharmacological
ABVD/MOPP compared to ABVD/OPP
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Intervention_Physical
( ABVD/MOPP )
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Intervention_Physical
ABVD/OPP
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Outcome_Other
efficacy and toxicity
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Outcome_Mortality
actuarial survival curves
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Outcome_Physical
CR rate
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Outcome_Adverse-effects
toxicity
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Outcome_Other
total relapses
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Outcome_Physical
second CR
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Outcome_Physical
CR
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Outcome_Physical
low risk of relapse
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Outcome_Physical
acceptable toxicity
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Participant_Sample-size
218
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Participant_Condition
advanced stage Hodgkin 's disease ( HD )
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Participant_Condition
early stage patients with systemic symptoms and/or bulky disease
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Participant_Sample-size
218
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Participant_Condition
HD
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Participant_Sample-size
106 patients
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Participant_Condition
arm A ( ABVD/MOPP
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Participant_Sample-size
112
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Participant_Condition
arm B ( ABVD/OPP ) .
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Participant_Condition
ABVD/MOPP arm