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document
Comparison of 40 milliliters of 0.25 % intrapleural bupivacaine with epinephrine with 20 milliliters of 0.5 % intrapleural bupivacaine with epinephrine after cholecystectomy . To determine the influence of the volume of local anesthetic injected for intrapleural analgesia , 40 patients undergoing cholecystectomy were randomly allocated to two groups of 20 patients each . One group received 40 mL of 0.25 % bupivacaine with epinephrine injected intrapleurally postoperatively . The other group received 20 mL of 0.5 % bupivacaine with epinephrine . The onset time of analgesia was nearly the same in both groups and within 25 min all patients were nearly pain free . Our data demonstrate that 100 mg of bupivacaine with epinephrine elicits effective analgesia after cholecystectomy . There are only minor differences between 20 and 40 mL with regard to pain relief . The authors conclude that the volume of local anesthetic within the range of 20-40 mL in an adult has little influence on the extent or duration of intrapleural analgesia .
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Intervention_Pharmacological
bupivacaine
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Intervention_Pharmacological
epinephrine
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Intervention_Pharmacological
bupivacaine with epinephrine
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Intervention_Pharmacological
bupivacaine with epinephrine
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Outcome_Physical
onset time of analgesia
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Outcome_Pain
pain relief .
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Participant_Sample-size
40
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Participant_Sample-size
20