79882
document
Delayed alloimmunization using random single donor platelet transfusions : a prospective study in thrombocytopenic patients with acute leukemia . A randomized study was performed in 54 thrombocytopenic patients with acute leukemia . Alloimmunization of recipients of random multiple-donor platelet concentrates ( MD group ) was compared to that of patients receiving random single-donor platelets ( SD group ) . In the SD patients , formation of alloantibodies ( mostly anti-HLA ) occurred less frequently ( p less than 0.002 ) , after a longer time period ( p less than 0.002 ) , and after a higher number of transfusions ( p less than 0.005 ) as compared to MD patients . SD patients also became refractory to random platelets less frequently ( p less than 0.005 ) , after a longer time period , and after a higher number of transfusions ( p less than 0.02 ) . In SD patients , the increments after the first and the last transfusion were in the same range , whereas in MD patients , the 1-hr ( p less than 0.001 ) and the 24-hr ( p less than 0.025 ) increments decreased from the first to the last transfusion . Thus , the use of random SD platelet transfusions postponed alloimmunization .
79883
Intervention_Physical
random single donor platelet transfusions
79884
Intervention_Pharmacological
multiple-donor platelet concentrates
79885
Intervention_Physical
random single-donor platelets
79886
Intervention_Physical
random SD platelet transfusions
79887
Outcome_Physical
Delayed alloimmunization
79888
Outcome_Physical
formation of alloantibodies ( mostly anti-HLA )
79889
Outcome_Other
higher number of transfusions
79890
Outcome_Physical
first and the last transfusion
79891
Participant_Condition
thrombocytopenic
79892
Participant_Condition
acute leukemia
79893
Participant_Sample-size
54
79894
Participant_Condition
thrombocytopenic
79895
Participant_Condition
acute leukemia