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document
A preliminary trial of ascorbic acid as supplemental therapy for autism . 1 . This study presents the results of a 30-week double-blind , placebo-controlled trial exploring the effectiveness of ascorbic acid ( 8g/70kg/day ) as a supplemental pharmacological treatment for autistic children in residential treatment . 2 . Residential school children ( N = 18 ) were randomly assigned to either ascorbate-ascorbate-placebo treatment order group or ascorbate-placebo-ascorbate treatment order group . Each treatment phase lasted 10 weeks and behaviors were rated weekly using the Ritvo-Freeman scale . 3 . Significant group by phase interactions were found for total scores and also sensory motor scores indicating a reduction in symptom severity associated with the ascorbic acid treatment . 4 . These results were consistent with a hypothesized dopaminergic mechanism of action of ascorbic acid .
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Intervention_Pharmacological
ascorbic acid
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
ascorbic acid
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Intervention_Pharmacological
ascorbate-ascorbate-placebo treatment order group
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Intervention_Pharmacological
ascorbate-placebo-ascorbate treatment
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Intervention_Pharmacological
ascorbic acid treatment
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Intervention_Pharmacological
ascorbic acid
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Outcome_Physical
total scores
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Outcome_Physical
sensory motor scores
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Outcome_Physical
symptom severity
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Participant_Condition
autism .
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Participant_Age
autistic children in residential treatment .
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Participant_Age
Residential school children ( N = 18 )