78285
document
Comparison between the central effects of camazepam and temazepam . Computerized analysis of sleep recordings . The effects of acute administration per os of 30 mg camazepam and the same dose of temazepam , were compared with placebo in 8 young male volunteers , fully adapted to the laboratory environment by 6 nights of adaptation . The study was double-blind , in a random order , 10 days separating each session . Spectral analysis was performed on the all-night records ( 1-min epochs ) , and the relative power of six frequency bands calculated . Concerning sleep parameters , temazepam induces a statistically significant reduction of : phase shifts ; number of awakenings ; percent duration of sleep stages I and IV . A significant increase of the percent duration of stage II and sleep efficiency was also found . Camazepam shows modification , with the same trend , but not reaching statistical significance . Concerning spectral analysis , temazepam induces a light increase of the relative power of the slowest frequencies , paralleled by an increase of the fast bands , while major effects are found on the characteristic periodicity of delta activities , which appear disrupted by the drug . These effects are not evident with camazepam , which does not seem to distort the normal sleep pattern .
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Intervention_Pharmacological
camazepam and temazepam
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Intervention_Pharmacological
camazepam
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Intervention_Pharmacological
temazepam
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Intervention_Control
placebo
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Intervention_Pharmacological
temazepam
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Intervention_Pharmacological
Camazepam
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Intervention_Pharmacological
temazepam
78293
Intervention_Pharmacological
camazepam
78294
Outcome_Physical
sleep parameters
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Outcome_Physical
percent duration of stage II
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Outcome_Other
sleep efficiency
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Outcome_Other
Camazepam shows modification
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Outcome_Other
temazepam