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Psychological well-being correlates with free thyroxine but not free 3,5,3'-triiodothyronine levels in patients on thyroid hormone replacement . CONTEXT AND OBJECTIVE An association between mood disorders and overt thyroid dysfunction is well established , but there are few data on the potential for thyroid hormone levels closer to the reference range to correlate with psychological well-being . DESIGN , SETTING , AND PATIENTS We analyzed the relationship between psychological well-being and free T ( 4 ) ( fT4 ) , free T ( 3 ) ( fT3 ) , TSH , and total rT ( 3 ) in 697 patients on thyroid hormone replacement therapy at entry to a randomized , controlled trial of combined T ( 4 ) and T ( 3 ) replacement therapy . All patients were on 100 mug or more T ( 4 ) . INTERVENTIONS AND MAIN OUTCOME MEASURES Psychological well-being was assessed with General Health Questionnaire-12 ( GHQ-12 ) , Thyroid Symptom Questionnaire , and Hospital Anxiety and Depression Scale . RESULTS fT ( 4 ) and TSH showed a strong correlation with GHQ-12 scores ( fT4 - b : -0.16 , P = 0.005 ; TSH - b : 0.663 , P = 0.04 ) . No correlations were seen between the GHQ scores and fT3 ( b : 0.318 , P = 0.275 ) , rT ( 3 ) ( b : 0.095 , P = 0.95 ) , rT ( 3 ) to fT4 ratio ( b : 71.83 , P = 0.09 ) or fT3 to rT ( 3 ) ratio ( b : 0.05 , P = 0.32 ) . The correlations remained when the data set was limited to patients with TSH in the range 0.3-4.0 mIU/liter . Similar correlations were seen with the Thyroid Symptom Questionnaire , although not with the Hospital Anxiety and Depression Scale scores . CONCLUSIONS Differences in fT4 and TSH concentration , even within the reference range , may be a determinant of psychological well-being in treated hypothyroid patients although not necessarily with symptoms typical of anxiety or depression .
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Intervention_Pharmacological
thyroid hormone replacement therapy
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Intervention_Pharmacological
combined T ( 4 ) and T ( 3 ) replacement therapy
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Outcome_Mental
Psychological well-being
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Outcome_Mental
General Health Questionnaire-12 ( GHQ-12 )
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Outcome_Mental
Thyroid Symptom Questionnaire
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Outcome_Mental
Hospital Anxiety
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Outcome_Mental
Depression Scale
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Outcome_Physical
Thyroid Symptom Questionnaire
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Outcome_Physical
Hospital Anxiety and Depression Scale scores
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Participant_Condition
thyroid hormone replacement
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Participant_Sample-size
697
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Participant_Condition
thyroid hormone replacement therapy
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Participant_Condition
hypothyroid