78503
document
[ Long-term treatment of cerebrovascular changes in the elderly ( author 's transl ) ] . A prospective study over 15 months in 100 elderly patients with signs of cerebro-vascular impairment demonstrated by psychometric testing that Hydergine ( an ergot alkaloid preparation : 4.5 mg daily ) compensated the signs of dementia , present in the placebo group , and in some patients actually brought about a significant improvement in mental activity . Similar compensatory effect was also demonstrable in cerebral haemodynamics : in the placebo group there was a progressive increase in cerebral circulation time , an expression of decreased cerebral blood flow , while with Hydergine cerebral circulation time was shortened and stabilized . Serial EEGs , obtained in parallel with psychometric and circulation time tests , demonstrated a marked increase in the 8-10 Hz pattern which corresponds to the physiological alpha activity in this age group . Furthermore , there was a diminished variability in performance in the tested frequency bands with Hydergine , the opposite tendency being obtained in the placebo group .
78504
Intervention_Pharmacological
Hydergine
78505
Intervention_Control
placebo
78506
Intervention_Control
placebo
78507
Intervention_Pharmacological
Hydergine
78508
Intervention_Pharmacological
Hydergine
78509
Intervention_Control
placebo
78510
Outcome_Mental
improvement in mental activity
78511
Outcome_Other
compensatory effect
78512
Outcome_Physical
cerebral haemodynamics
78513
Outcome_Physical
progressive increase in cerebral circulation time
78514
Outcome_Physical
expression of decreased cerebral blood flow
78515
Outcome_Other
8-10 Hz pattern
78516
Outcome_Other
performance
78517
Participant_Condition
elderly