33548
document
Intra-operative antibiotic prophylaxis in neurosurgery . A prospective , randomized , controlled study on cefotiam . In this prospective , randomized and controlled study the effect of cefotiam for the prevention of wound infections following trepanations was investigated . The main interest was centered on the rate of post-operative bone flap infections requiring operative revision . Administration of cefotiam was randomized for patients undergoing major craniotomies . The antibiotic was administered intravenously in a single dose of 2 g with induction of anaesthesia . Only clean or clean contaminated cases were included . Excluded were contaminated cases , operations with a transnasal-transsphenoidal approach , shunt-operations and patients with any other preoperative infection or antibiotic therapy . Outpatients were excluded due to difficulties in obtaining sufficient clinical information . From originally 918 consecutive patients operated on 711 fulfilled the entry criteria . With regard to age , sex , diagnosis and the site of te trepanation , control patients ( n = 355 ) and cefotiam treated patients ( n = 356 ) were shown to be comparable . In the various subgroups formed for different primary diagnoses , concomitant steroidal therapy and concomitant severe internal medical diseases cefotiam treated patients and controls were comparable as well . A highly significant difference for bone flap infection could be shown with 0.3 % in the cefotiam group versus 5.1 % in the control group ( p less than 0.001 ) . The overall rate of post-operative deep wound infections including meningitis and abscesses was also significantly ( p less than 0.005 ) different with 3.1 % in the cefotiam versus 9.0 % in the control group . Thus it was concluded that a single dose of cefotiam significantly reduces post-operative deep wound infection .
33549
Intervention_Pharmacological
antibiotic
33550
Intervention_Pharmacological
cefotiam
33551
Intervention_Pharmacological
cefotiam
33552
Intervention_Pharmacological
antibiotic
33553
Intervention_Pharmacological
anaesthesia
33554
Intervention_Pharmacological
antibiotic therapy
33555
Intervention_Control
control patients
33556
Intervention_Pharmacological
concomitant steroidal therapy
33557
Intervention_Pharmacological
cefotiam
33558
Outcome_Physical
bone flap infection
33559
Outcome_Physical
overall rate of post-operative deep wound infections including meningitis and abscesses
33560
Outcome_Physical
post-operative deep wound infection
33561
Participant_Sample-size
918
33562
Participant_Sample-size
711
33563
Participant_Sample-size
355
33564
Participant_Sample-size
356