56588
document
Memantine as adjunctive treatment to risperidone in children with autistic disorder : a randomized , double-blind , placebo-controlled trial . Autism is a neurodevelopmental disorder that causes significant impairment in socialization and communication . It is also associated with ritualistic and stereotypical behaviour . Recent studies propose both hyper-and hypoglutamatergic ideologies for autism . The objective of this study was to assess the effects of memantine plus risperidone in the treatment of children with autism . Children with autism were randomly allocated to risperidone plus memantine or placebo plus risperidone for a 10-wk , double-blind , placebo-controlled study . The dose of risperidone was titrated up to 3 mg/d and memantine was titrated to 20 mg/d . Children were assessed at baseline and after 2 , 4 , 6 , 8 and 10 wk of starting medication protocol . The primary outcome measure was the irritability subscale of Aberrant Behavior Checklist-Community ( ABC-C ) . Difference between the two treatment arms was significant as the group that received memantine had greater reduction in ABC-C subscale scores for irritability , stereotypic behaviour and hyperactivity . Eight side-effects were observed over the trial , out of the 25 side-effects that the checklist included . The difference between the two groups in the frequency of side-effects was not significant . The present study suggests that memantine may be a potential adjunctive treatment strategy for autism and it was generally well tolerated . This trial is registered with the Iranian Clinical Trials Registry ( IRCT1138901151556N10 ; www.irct.ir ) .
56589
Intervention_Pharmacological
Memantine
56590
Intervention_Pharmacological
risperidone
56591
Intervention_Control
placebo-controlled
56592
Intervention_Pharmacological
memantine plus risperidone
56593
Intervention_Pharmacological
risperidone plus memantine
56594
Intervention_Control
placebo plus risperidone
56595
Intervention_Pharmacological
risperidone
56596
Outcome_Mental
irritability subscale of Aberrant Behavior Checklist-Community ( ABC-C )
56597
Outcome_Mental
ABC-C subscale scores for irritability , stereotypic behaviour and hyperactivity
56598
Participant_Condition
autistic disorder
56599
Participant_Age
children
56600
Participant_Condition
autism
56601
Participant_Condition
autism