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document
Early immunisation with hepatitis B vaccine : a five-year study . We evaluated the response to the recombinant Hepatitis B vaccine using an accelerated schedule versus the traditional schedule by studying the immunologic memory induced in 200 children with HBs-Ag negative mothers . At seroconversion , the traditional schedule presented a higher percentage of children with serum HBs-Ag concentrations over 100 mIU/ml than the accelerated schedule . After five years this difference was no longer statistically significant and children who presented anti-HBsAg concentrations below 10 mUI/ml received an additional booster dose which stimulated the antibody concentration to exceed 100 mIU/ml in all cases . Recombinant HBV vaccine induced better long term immunologic memory when it was administered earlier .
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Intervention_Pharmacological
hepatitis B vaccine :
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Intervention_Pharmacological
recombinant Hepatitis B vaccine
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Intervention_Pharmacological
Recombinant HBV vaccine
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Outcome_Physical
anti-HBsAg concentrations below 10 mUI/ml
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Outcome_Physical
antibody concentration to exceed 100 mIU/ml
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Outcome_Physical
immunologic memory
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Participant_Sample-size
200
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Participant_Age
children
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Participant_Condition
HBs-Ag