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document
Effects of strontium on the quality of bone apatite crystals : a paired biopsy study in postmenopausal osteoporotic women . UNLABELLED In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months , characteristics of bone apatite crystals were not influenced by the presence of strontium . The mean rate of substitutions of calcium by strontium ions was 4.5 % . INTRODUCTION The potential effect of strontium ( Sr ) on bone apatite crystals was investigated in paired biopsies of osteoporotic women treated with either strontium ranelate ( SrRan ) or a placebo for 36 months . METHODS In ten paired biopsies , crystallinity , apparent length and width/thickness of crystals , interplanar distances , and lattice parameters of unit cells were assessed by X-ray diffraction and selected area electron diffraction . RESULTS All these parameters , reflecting crystal and unit cell characteristics , were not influenced by the presence of Sr and were similar in SrRan and placebo groups after 36 months of treatment . The mean rate of substitutions of calcium by Sr ions was 4.5 % . CONCLUSION Overall , the quality of bone apatite crystals was maintained after 36 months of treatment with SrRan .
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Intervention_Pharmacological
strontium
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Intervention_Pharmacological
strontium ranelate
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Intervention_Control
placebo
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Intervention_Pharmacological
strontium
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Intervention_Pharmacological
strontium
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Intervention_Pharmacological
strontium ranelate ( SrRan )
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Intervention_Control
placebo
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Intervention_Pharmacological
SrRan
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Intervention_Control
placebo
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Intervention_Pharmacological
SrRan
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Outcome_Physical
quality of bone apatite crystals :
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Outcome_Physical
mean rate of substitutions
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Outcome_Physical
crystallinity , apparent length and width/thickness of crystals , interplanar distances , and lattice parameters of unit cells
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Outcome_Physical
mean rate of substitutions of calcium by Sr ions
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Outcome_Physical
quality of bone apatite crystals
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Participant_Condition
postmenopausal osteoporotic
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Participant_Sex
women
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Participant_Condition
biopsies
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Participant_Condition
osteoporotic
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Participant_Sex
women
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Participant_Condition
osteoporotic
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Participant_Sex
women
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Participant_Sample-size
ten