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Neck circumference and early stage atherosclerosis : the cardiometabolic risk in Chinese ( CRC ) study . BACKGROUND Neck circumference ( NC ) has been previously related to cardiometabolic risk factors . In this study we examined the association between NC and early stage atherosclerosis in Chinese adults . METHODS The study samples were from a community-based health examination survey in central China . In total 2,318 men and women ( 18-64 y ) were included in the final analyses . Carotid radial pulse wave velocity ( crPWV ) , carotid femoral PWV ( cfPWV ) , carotid artery dorsalis pedis PWV ( cdPWV ) and NC were measured . RESULTS After adjustment for age , sex , lipids , glucose , blood pressure , heart rate , body mass index ( BMI ) , high NC was significantly associated with an increasing trend of cfPWV , cdPWV and crPWV ( P = 0.001 , 0.049 , and 0.038 ; respectively ) . In addition , we found significant interaction between hypertension status and NC level in relation to cfPWV , adjusted for age , sex , BMI , fasting glucose , lipids and heart rate ( P for interaction = 0.034 ) . The associations between NC and cfPWV were significant ( P = 0.02 ) among those with hypertension , but not significant among those without hypertension . CONCLUSIONS Our data showed that high NC was associated with an increased risk of early stage atherosclerosis in Chinese adults , independent of other metabolic risk factors . Hypertension might modify the association between NC and cfPWV .
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Intervention_Other
Neck circumference
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Intervention_Educational
study samples were from a community-based health examination survey
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Intervention_Physical
Carotid radial pulse wave velocity ( crPWV )
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Intervention_Other
,
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Intervention_Physical
carotid femoral PWV ( cfPWV )
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Intervention_Physical
carotid artery dorsalis pedis PWV ( cdPWV ) and NC were measured
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Outcome_Physical
Carotid radial pulse wave velocity ( crPWV ) , carotid femoral PWV ( cfPWV )
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Outcome_Physical
carotid artery dorsalis pedis PWV ( cdPWV )
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Outcome_Physical
NC
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Outcome_Physical
cfPWV
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Outcome_Physical
cdPWV
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Outcome_Physical
crPWV
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Outcome_Physical
hypertension status
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Outcome_Physical
NC level
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Participant_Condition
early stage atherosclerosis
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Participant_Condition
early stage atherosclerosis
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Participant_Age
adults .
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Participant_Sample-size
2,318
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Participant_Sex
men
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Participant_Sex
women
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Participant_Age
18-64 y
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Participant_Condition
early stage atherosclerosis
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Participant_Condition
Chinese