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document
Short-term effects of systemic antibiotics during periodontal healing . OBJECTIVES To investigate the short-term effects of nonsurgical therapy ( scaling and root planing , SRP ) on the subgingival microbiota in chronic ( CP ) and aggressive ( AP ) periodontal disease . METHOD AND MATERIALS Ninety-seven CP and AP subjects underwent full-mouth SRP on 2 consecutive days . AP patients were randomly assigned to either receive systemic metronidazole plus amoxicillin ( AP+AB ) or were treated mechanically alone ( AP ) . Pathogens were identified with 16S rRNA oligodeoxynucleotide probes and dot-blot hybridization before and at days 2 , 3 , 4 , 7 , 10 , and 21 of healing . CP subjects were treated by scaling and root planing along with placebo tablets . RESULTS Initially , AP cell counts were 69.9- ( Porphyromonas gingivalis ) , 10.2- ( Aggregatibacter actinomycetemcomitans ) , 5.7- ( Tannerella forsythia ) , and 3.3-fold ( Prevotella intermedia ) enhanced compared to CP cell counts . Following SRP , immediate elimination occurred in single individuals of all three treatment groups at day 2 . After SRP plus antibiotic therapy ( AP+AB ) , the prevalence scores dropped beyond the levels of AP and CP , beginning at day 7 , and remained low until day 21 ( P =or < .05 ) . Clinical healing statistically benefited from SRP with no differences among the three treatment groups . CONCLUSION Nonsurgical therapy resulted in both a suppression and early elimination of single taxa immediately after completion of active treatment . Systemic antibiotics significantly accelerate the suppression of the periodontal microflora , but have limited effect on the elimination of target isolates during healing .
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Intervention_Pharmacological
antibiotics
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Intervention_Pharmacological
systemic metronidazole plus amoxicillin ( AP+AB )
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Intervention_Pharmacological
treated mechanically alone ( AP )
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Intervention_Control
placebo tablets .
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Intervention_Pharmacological
SRP plus antibiotic therapy
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Outcome_Other
effects
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Outcome_Physical
16S rRNA oligodeoxynucleotide probes and dot-blot hybridization
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Outcome_Physical
AP cell counts
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Outcome_Other
SRP plus antibiotic therapy
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Outcome_Physical
AP
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Outcome_Physical
CP
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Outcome_Physical
Clinical healing
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Outcome_Physical
single taxa
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Outcome_Physical
periodontal microflora
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Participant_Condition
periodontal healing .
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Participant_Condition
nonsurgical therapy ( scaling and root planing , SRP ) on the subgingival microbiota in chronic ( CP ) and aggressive ( AP ) periodontal disease .