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document
Movement-related potentials in Parkinson 's disease . Presence and predictability of temporal and spatial cues . Activity of the supplementary motor area may be inferred from movement-related potentials ( MRPs ) which are associated with the preparation and execution of voluntary , or internally determined movements . Supplementary motor area activity may be abnormal in Parkinson 's disease since its major input from the basal ganglia is disrupted . Investigation of the abnormalities in supplementary motor area activity associated with movement deficits in Parkinson 's disease may therefore reveal functions of the basal ganglia and the supplementary motor area . Movement-related potentials associated with sequential movements were investigated under various cueing conditions in Parkinson 's disease subjects and age-matched controls . In controls , MRPs revealed involvement of the supplementary motor area in movements which can be internally determined ( non-cued and externally cued , predictable movements , but not unpredictable movements ) . In Parkinson 's disease , however , the supplementary motor area was only involved in movements which must be internally determined ( non-cued movements , but not externally cued movements ) ; therefore impaired internal control mechanisms , operating via the supplementary motor area , are bypassed when external cues are given . As a result , Parkinson 's disease patients are more reliant on external cues and are unable to use predictive models to internally guide movement . Supplementary motor area involvement also relied on the predictability ( in controls ) or presence ( in Parkinson 's disease ) of timing cues and not spatial cues , indicating a role of the supplementary motor area and basal ganglia in the temporal organizations of sequential movement rather than the programming of specific movements . For non-cued movements , abnormalities in MRPs for Parkinson 's disease subjects consisted of delayed MRP onset and peak times , and prolonged cortical activity following movement . These observations led to a proposed model of the interaction between the basal ganglia and the supplementary motor area , involving the temporal organization of voluntary and internally determined sequential movements .
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Intervention_Physical
Movement-related potentials
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Intervention_Physical
movement-related potentials ( MRPs )
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Intervention_Educational
Movement-related potentials
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Intervention_Control
controls
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Intervention_Physical
non-cued
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Intervention_Physical
externally cued
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Intervention_Physical
predictable
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Intervention_Educational
not unpredictable
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Intervention_Physical
not externally cued
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Intervention_Physical
timing cues
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Outcome_Other
delayed MRP onset
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Outcome_Other
peak times
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Participant_Condition
Parkinson 's disease
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Participant_Condition
Parkinson 's disease
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Participant_Condition
Parkinson 's disease
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Participant_Condition
Parkinson 's disease