85405
document
Torasemide versus furosemide in cirrhosis : a long-term , double-blind , randomized clinical study . The effects of long-term therapy ( 70 days ) with torasemide ( 20 mg/day ) , a new loop diuretic , were compared with those of furosemide ( 50 mg/day ) in a randomized double-blind trial . Both drugs were administered in association with spironolactone ( 200 mg/day ) in 28 nonazotemic cirrhotic patients with controlled ascites . The treatments did not modify creatinine clearance and exhibited a similar effect on body weight , urinary volume , and fractional excretion of uric acid , sodium , and chloride . The effect of torasemide on fractional potassium excretion was lower than that of furosemide . Torasemide showed higher sparing effect than furosemide on calcium , inorganic phosphate , and magnesium excretion and stronger action on free water clearance . No changes in serum parameters were induced by either treatment . Two episodes of hepatic encephalopathy occurred in the torasemide group . In view of its effects on sodium and water excretion and on other urinary parameters , torasemide can represent an alternative tool for the long-term treatment of ascites .
85406
Intervention_Pharmacological
Torasemide
85407
Intervention_Pharmacological
furosemide
85408
Intervention_Pharmacological
torasemide
85409
Intervention_Pharmacological
furosemide
85410
Intervention_Pharmacological
spironolactone
85411
Intervention_Pharmacological
torasemide
85412
Intervention_Pharmacological
furosemide
85413
Intervention_Pharmacological
Torasemide
85414
Intervention_Pharmacological
furosemide
85415
Intervention_Pharmacological
torasemide
85416
Intervention_Pharmacological
torasemide
85417
Outcome_Physical
creatinine clearance
85418
Outcome_Physical
body weight , urinary volume
85419
Outcome_Physical
fractional excretion of uric acid , sodium , and chloride
85420
Outcome_Physical
fractional potassium excretion
85421
Outcome_Physical
calcium , inorganic phosphate , and magnesium excretion
85422
Outcome_Physical
free water clearance
85423
Outcome_Physical
serum parameters
85424
Outcome_Adverse-effects
hepatic encephalopathy
85425
Outcome_Physical
effects on sodium and water excretion
85426
Outcome_Physical
on other urinary parameters