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document
Multisite , double-blind , placebo-controlled trial of porcine secretin in autism . OBJECTIVE To examine the efficacy of intravenous porcine secretin for the treatment of autistic disorder . METHOD Randomized , double-blind , placebo-controlled , crossover design . Fifty-six subjects with autistic disorder received either a secretin or placebo infusion at baseline and the other substance at week 4 . Subjects were given the Autism Diagnostic Observation Schedule ( ADOS ) and other pertinent developmental measures at baseline and at weeks 4 and 8 to assess drug effects . RESULTS For the primary efficacy analysis , change of ADOS social-communication total score from week 0 to week 4 , no statistically significant difference was obtained between placebo ( -0.8 +/- 2.9 ) and secretin groups ( -0.6 +/- 1.4 ; t54 = 0.346 , p < .73 ) . The other measures showed no treatment effect for secretin compared with placebo . CONCLUSION There was no evidence for efficacy of secretin in this randomized , placebo-controlled , double-blind trial .
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
porcine secretin
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Intervention_Pharmacological
porcine secretin
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
secretin
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Intervention_Control
placebo infusion
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Intervention_Control
placebo
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Intervention_Pharmacological
secretin
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Intervention_Pharmacological
secretin
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Intervention_Control
placebo
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Outcome_Other
efficacy
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Outcome_Other
treatment
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Outcome_Physical
autistic disorder
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Outcome_Mental
Autism Diagnostic Observation Schedule ( ADOS )
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Outcome_Mental
pertinent developmental measures
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Outcome_Mental
ADOS social-communication total score
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Outcome_Physical
treatment effect
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Outcome_Other
efficacy
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Participant_Condition
autism
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Participant_Condition
autistic disorder .
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Participant_Sample-size
Fifty-six
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Participant_Condition
autistic disorder