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document
Evolution of coronary stenoses is related to baseline severity -- a prospective quantitative angiographic analysis in patients with moderate coronary disease . INTACT Investigators . International Nifedipine Trial on Antiatherosclerotic Therapy . A correlation of the angiographic evolution of coronary stenoses ( stenosis diameter > or = 20 % ) with morphological stenosis parameters at baseline could help to identify the risk of progressive stenoses . Therefore , the data of the prospective INTACT study ( International Nifedipine Trial on Antiatherosclerotic Therapy ) were reviewed . In 348 patients with moderate coronary artery disease , standardized coronary angiograms were taken 3 years apart and were quantitatively analysed . Changes in the minimal diameter of the 1063 preexisting coronary stenoses compared between both angiograms were set in relation to a number of conventional stenosis parameters at baseline . Regression analysis demonstrated a significant correlation of the changes in minimal diameter with baseline % diameter stenosis ( r = 0.30 ; P < 0.001 ) , minimal diameter ( r = -0.28 ; P < 0.001 ) and reference diameter of stenoses ( r = -0.14 ; P < 0.001 ) . The changes were not correlated with stenosis length and plaque area . The baseline parameters of 22 preexisting stenoses progressing to occlusions differed from those remaining patent only with regard to the % diameter stenosis ( 43 +/- 9 % vs 39 +/- 11 % ; P < 0.05 ) . Additional progression of coronary disease became manifest through development of 228 stenoses and 19 occlusions at arterial sites free from definitive stenoses in the baseline angiograms . Thus , progression of atherosclerosis predominantly occurred in mild preexisting coronary stenoses and developed at previously angiographically normal sites . Since the conventional angiographic parameters analysed in this study failed to identify individual arterial sites with an increased risk for progression , definition of new angiographic parameters or application of new techniques seem mandatory to this end .
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Intervention_Physical
standardized coronary angiograms
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Outcome_Physical
identify the risk of progressive stenoses .
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Outcome_Physical
minimal diameter
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Outcome_Physical
number of conventional stenosis parameters
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Outcome_Other
correlation
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Outcome_Physical
changes in minimal diameter
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Outcome_Physical
baseline % diameter stenosis
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Outcome_Physical
minimal diameter
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Outcome_Physical
reference diameter of stenoses
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Outcome_Physical
changes were not correlated
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Outcome_Physical
stenosis length and plaque area .
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Outcome_Physical
progressing to occlusions
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Outcome_Physical
remaining patent
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Outcome_Physical
% diameter stenosis
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Outcome_Physical
progression of coronary disease
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Outcome_Physical
stenoses
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Outcome_Physical
occlusions
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Outcome_Physical
progression of atherosclerosis predominantly occurred
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Participant_Condition
moderate coronary disease
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Participant_Sample-size
348
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Participant_Condition
moderate coronary artery disease ,