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document
Research Units of Pediatric Psychopharmacology ( RUPP ) autism network randomized clinical trial of parent training and medication : one-year follow-up . OBJECTIVE To follow up on a three-site , 24-week randomized clinical trial ( N = 124 ) comparing antipsychotic medication alone ( MED ) with antipsychotic medication plus parent training in the behavior management ( COMB ) of children with autism spectrum disorders and severe behavior problems . The COMB treatment had shown a significant advantage for child behavioral noncompliance ( p = .006 , d = 0.34 ) , irritability ( p = .01 , d = 0.48 ) , and hyperactivity/noncompliance ( p = .04 , d = 0.55 ) with a lower medication dose . METHOD One year after each participant 's termination , the authors mailed an assessment packet with a return-addressed envelope ; a telephone call alerted the family . Failure to return packets within 1 month elicited another contact and offers to resend . RESULTS Eighty-seven of 124 families ( 70.2 % ) participated in the follow-up . The improvement difference between treatments attenuated from after treatment to follow-up for noncompliance ( d = 0.32 to 0.12 ) and irritability ( d = 0.46 to 0.03 ) . The follow-up differences were nonsignificant ( the noncompliance difference also was nonsignificant after treatment for these 87 families ) . Sixty-seven percent of the COMB group and 53 % of the MED group were still taking risperidone , the original study medication . Most needed dose adjustments or additional medication , and the COMB group no longer had a significantly lower dose . All COMB families but only 39 % of MED families reported seeking parent training after treatment . Improvements in daily living skills during treatment predicted noncompliance improvement at follow-up for the COMB children , but noncompliance deterioration and especially hyperactivity/noncompliance deterioration for the MED children . CONCLUSIONS The study treatment experience/familiarity greatly influenced the follow-up treatment : those who had received parent training reported seeking it , whereas those who had not received it tended not to seek it . The superiority of COMB over MED after treatment attenuated by more than half at follow-up .
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Intervention_Pharmacological
antipsychotic medication alone
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Intervention_Educational
antipsychotic medication plus parent training
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Intervention_Pharmacological
risperidone
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Outcome_Mental
behavior management
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Outcome_Mental
child behavioral noncompliance
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Outcome_Mental
hyperactivity/noncompliance
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Outcome_Mental
seeking parent training
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Outcome_Mental
Improvements in daily living skills
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Outcome_Mental
noncompliance deterioration and especially hyperactivity/noncompliance deterioration
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Participant_Condition
Research Units of Pediatric Psychopharmacology ( RUPP ) autism network
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Participant_Sample-size
( N = 124 )
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Participant_Age
children
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Participant_Condition
autism spectrum disorders and severe behavior problems
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Participant_Age
child