29918
document
Ciprofloxacin/dexamethasone drops decrease the incidence of physician and patient outcomes of otorrhea after tube placement . OBJECTIVE To evaluate ciprofloxacin 0.3 % /dexamethasone 0.1 % ( CIPRODEX , Alcon , Ft. Worth , TX ) for the prevention of early post-operative otorrhea following TT placement . METHODS This was a single-center , randomized , evaluator-blinded , parallel-group study . Two hundred children undergoing bilateral TT placement were categorized as having unilateral ( " wet/dry " ) , bilateral ( " wet/wet " ) , or no ( " dry/dry " ) effusion at the time of surgery . All patients received Ciprodex or no treatment for 5 days post-operatively and returned at 2 weeks . RESULTS Physician-observed otorrhea was reported in 5 ( 4.95 % ) patients receiving Ciprodex and 39 ( 39.39 % ) patients receiving no treatment ( p < 0.0001 ) . Treatment decreased otorrhea in all groups , while the greatest benefit was observed in patients with bilateral effusion ( 93 % reduction ) . Ciprodex treatment also decreased the rate of clinically diagnosed otitis media ( OM ) and effusion following TT placement ( p < or =0.0006 ) . CONCLUSION Ciprodex reduced early post-operative otorrhea , clinically diagnosed OM and effusion following TT insertion . The greatest reduction in otorrhea was observed in patients with bilateral effusion at the time of surgery .
29919
Intervention_Pharmacological
Ciprofloxacin/dexamethasone
29920
Intervention_Pharmacological
ciprofloxacin 0.3 % /dexamethasone
29921
Intervention_Pharmacological
Ciprodex
29922
Intervention_Control
no treatment for 5 days post-operatively
29923
Outcome_Physical
otorrhea
29924
Outcome_Physical
Physician-observed otorrhea
29925
Outcome_Physical
otorrhea
29926
Outcome_Physical
rate of clinically diagnosed otitis media ( OM )
29927
Outcome_Physical
effusion
29928
Outcome_Physical
early post-operative otorrhea
29929
Outcome_Physical
clinically diagnosed OM
29930
Outcome_Physical
effusion
29931
Outcome_Physical
otorrhea