41546
document
Clinical trial of tooth whitening with 6 % hydrogen peroxide whitening strips and two whitening dentifrices . PURPOSE To compare tooth whitening with 6 % hydrogen peroxide whitening strips and two whitening dentifrices in a 12-week randomized controlled trial at a Belgian dental school . METHODS After informed consent , 46 healthy adults were randomly assigned to one of three strip + dentifrice treatment groups . Subjects received either 6 % hydrogen peroxide whitening strips ( Crest Whitestrips ) and an anticavity toothpaste ( Crest Cavity Protection ) , placebo strips and a sodium fluoride ( NaF ) whitening dentifrice ( Mentadent Whitening Toothpaste ) or placebo strips and a sodium monofluorophosphate ( MFP ) whitening dentifrice ( Rembrandt Low Abrasion Whitening Toothpaste ) . Strip use ( peroxide or placebo ) was for 30 minutes , twice daily for 2 weeks , while dentifrice use was at least twice daily for 12 weeks . Efficacy was measured from standardized digital images of the maxillary facial tooth surfaces , while safety was evaluated from oral examination and interview . Treatments were compared after 2 weeks ( strip use ) and 12 weeks ( dentifrice use ) using analysis of covariance . RESULTS All subjects completed the 12-week evaluation . Adjusting for baseline and age , the peroxide strip group had -2.45 Deltab* , 2.39 DeltaL* , and -0.96 Deltaa* at Week 2 . Between-group comparisons demonstrated significant ( P < 0.0001 ) reductions in yellowness and redness , and increased brightness favoring the peroxide strip group . The peroxide strip group demonstrated 95 % + color retention ( Deltab* & DeltaL* ) at Week 12 , differing significantly ( P < 0.0001 ) versus either of the continuously used whitening dentifrices . There were no significant ( P > 0.18 ) differences between the whitening dentifrice groups at any timepoints . All treatments were well-tolerated , with minor tooth sensitivity and oral irritation representing the most common findings .
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Intervention_Pharmacological
hydrogen peroxide
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Intervention_Psychological
whitening strips
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Intervention_Pharmacological
whitening dentifrices .
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Intervention_Pharmacological
hydrogen peroxide whitening strips
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Intervention_Pharmacological
whitening dentifrices
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Intervention_Pharmacological
strip
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Intervention_Pharmacological
dentifrice
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Intervention_Pharmacological
6 % hydrogen peroxide whitening strips ( Crest Whitestrips )
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Intervention_Pharmacological
anticavity toothpaste
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Intervention_Control
placebo strips
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Intervention_Control
placebo strips
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Intervention_Control
sodium monofluorophosphate ( MFP ) whitening dentifrice
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Intervention_Pharmacological
peroxide
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Intervention_Control
placebo
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Intervention_Pharmacological
peroxide strip
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Intervention_Pharmacological
whitening dentifrices
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Outcome_Physical
tooth whitening
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Outcome_Physical
tooth whitening
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Outcome_Other
Efficacy
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Outcome_Physical
yellowness and redness
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Outcome_Physical
brightness favoring
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Outcome_Physical
color retention
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Outcome_Other
well-tolerated
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Outcome_Adverse-effects
minor tooth sensitivity
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Outcome_Adverse-effects
oral irritation
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Participant_Sample-size
46
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Participant_Age
adults