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document
[ The prognostic value of gastric metaplasia in the duodenal mucosa in patients with Helicobacter pylori positive duodenal bulb ulcer ] . The predictive value of gastric metaplasia in the duodenal mucosa in patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU ) was investigated . One hundred and twenty four randomly selected patients with DBU were included in this prospective study . The detection of Helicobacter pylori ( HP ) in the stomach and duodenum was carried out with Giemsa ( using standard visual analogue scale ) , rapid urease test ( standard Jatrox-HP test , Rohm Pharma , Germany ) , and polymerase chain reaction ( PCR ) to detect the specific fragment of ureC HP gene ( Helicopol II , Lytech , Russia ) . Regions of gastric metaplasia of the duodenum were confirmed by periodic acid-Schiff and alcian blue ( Serva ) staining ( pH 1.0 ; 2.5 ) Duodenal ulcer ( DU ) complications were registered within 8 to 10 years . Estimation of the predictive factor ( gastric metaplasia in the duodenum ) was carried out in patients with non-complicated DU ( Group 1 ; n = 73 ) , and with such complications as bleeding , perforation , penetration , pyloroduodenal stenosis ( Group 2 ; n = 51 ) which were revealed within the 8 to 10 years of observation . Gastric metaplasia in the duodenum was found in 64 or 87.7 % of the 73 patients with non-complicated DU and in 5 or 9.8 % of the 51 patients with complicated DU within 8 to 10 years of observation . The following facts about the predictive factor for the prognosis of DU complication were found : the sensitivity of 83.6 % , the specificity of 92.8 % , the predictive accuracy of 88.7 % , the relative risk of the predicted outcome of 7.5 , the relative risk of a different outcome of 0.11 , the odds ration of 65.4 . The study revealed a high and significant ( p < 0.001 ) predictive value of gastric metaplasia in the duodenum as a marker of non-complicated clinical course of DU in HP-positive patients within an 8 to 10-year period .
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Outcome_Physical
( gastric metaplasia in the duodenum )
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Outcome_Physical
Gastric metaplasia in the duodenum
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Outcome_Other
sensitivity
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Outcome_Other
specificity
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Outcome_Other
predictive accuracy
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Outcome_Physical
gastric metaplasia
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Participant_Condition
patients with Helicobacter pylori positive duodenal bulb ulcer
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Participant_Condition
patients Helicobacter pylori-positive patients with duodenal bulb ulcer ( DBU )
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Participant_Sample-size
One hundred and twenty four
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Participant_Condition
patients with DBU
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Participant_Condition
HP-positive patients