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document
Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly : A Randomized Controlled Study . Transcranial magnetic stimulation ( TMS ) is a noninvasive brain stimulation technique with potential to improve memory . Mild cognitive impairment ( MCI ) , which still lacks a specific therapy , is a clinical syndrome associated with increased risk of dementia . This study aims to assess the effects of high-frequency repetitive TMS ( HF rTMS ) on everyday memory of the elderly with MCI . We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex ( DLPFC ) . Thirty-four elderly outpatients meeting Petersen 's MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham , 10 Hz rTMS at 110 % of motor threshold , 2,000 pulses per session . Neuropsychological assessment at baseline , after the last session ( 10th ) and at one-month follow-up , was applied . ANOVA on the primary efficacy measure , the Rivermead Behavioural Memory Test , revealed a significant group-by-time interaction ( p = 0.05 ) , favoring the active group . The improvement was kept after one month . Other neuropsychological tests were heterogeneous . rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions . These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration .
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Intervention_Physical
Transcranial Magnetic Stimulation
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Intervention_Physical
Transcranial magnetic stimulation ( TMS )
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Intervention_Physical
high-frequency repetitive TMS ( HF rTMS )
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Intervention_Physical
rTMS
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Outcome_Mental
the Rivermead Behavioural Memory Test
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Outcome_Mental
rTMS at 10 Hz enhanced everyday memory
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Participant_Condition
Mild Cognitive Impairment
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Participant_Condition
Mild cognitive impairment ( MCI )
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Participant_Condition
MCI
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Participant_Sample-size
Thirty-four
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Participant_Age
elderly
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Participant_Condition
MCI
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Participant_Age
elderly