15955
document
The long-term effect of oxandrolone on hepatic acute phase proteins in severely burned children . BACKGROUND Acute phase protein production is a hallmark of severe burns . We wondered whether anabolic treatment with oxandrolone would affect these proteins . METHODS Thirty-five children with > or =40 % total body surface area burns were randomized to receive either placebo or oxandrolone ( 0.1 mg/kg by mouth twice daily ) from postoperative day 5 to 1 year postburn . Levels of constitutive proteins and acute phase proteins were measured at admission ; at discharge ; and at 6 , 9 , and 12 months after burn . Total albumin supplementation and hepatic transaminases were also assessed . RESULTS Constitutive proteins such as albumin , prealbumin , and retinol-binding protein levels increased ( p < 0.05 ) , and acute phase proteins such as alpha 1-acid glycoprotein , C3 complement , alpha 2-macroglobulin , and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo ( p < 0.05 ) . Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group . Hepatic transaminases remained within normal levels . CONCLUSION Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels .
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Intervention_Pharmacological
oxandrolone
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Intervention_Control
placebo
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Intervention_Pharmacological
oxandrolone
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Outcome_Physical
Total albumin supplementation
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Outcome_Physical
hepatic transaminases
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Outcome_Physical
Constitutive proteins such as albumin , prealbumin , and retinol-binding protein levels
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Outcome_Physical
acute phase proteins such as alpha 1-acid glycoprotein , C3 complement , alpha 2-macroglobulin , and fibrinogen levels
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Outcome_Physical
Albumin supplementation during the acute hospitalization
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Outcome_Physical
Hepatic transaminases
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Outcome_Physical
constitutive protein
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Outcome_Physical
acute phase protein levels
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Participant_Condition
severely burned
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Participant_Age
children
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Participant_Sample-size
Thirty-five children