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document
[ Prophylactic use of low molecular weight heparin in combination with graduated compression stockings in post-operative patients with gynecologic cancer ] . OBJECTIVE The aim of this study was to compare the efficacy of low molecular weight heparin ( LMWH ) combined with graduated compression stockings ( GCS ) with GCS alone as prophylactic measures for venous thromboembolism ( VTE ) in post-operative patients with gynecologic cancer . METHODS Patients diagnosed with gynecologic cancer undergoing primary major surgery between 2010 and 2011 in our institute were randomized to receive LMWH+GCS or GCS as VTE prophylaxis post-operatively . RESULTS Altogether 247 patients were enrolled . The incidence of VTE in patients treated with LMWH + GCS was significantly lower than that in patients using GCS alone ( 0.8 % Vs. 8.1 % , P = 0.01 ) . There were no severe bleeding complications in the patients with prophylactic use of LMWH and the occurrence rate of wound dehiscence was comparable between the two groups ( P > 0.05 ) . Multivariable logistic regression analysis revealed that age over 60 years ( P = 0.015 ) , duration of operation over 3 hours ( P = 0.04 ) and without prophylactic use of LMWH ( P = 0.02 ) were independent risk factors for VTE . CONCLUSIONS Dual prophylaxis with LMWH and GCS should be recommended for gynecologic cancer patients undergoing major surgery for its better efficacy than GCS . Prophylactic use of LMWH is safe and convenient . Patients with older age and prolonged operation time are at highest risk of developing VTE post-operatively .
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Intervention_Pharmacological
low molecular weight heparin
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Intervention_Physical
graduated compression stockings
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Intervention_Pharmacological
low molecular weight heparin ( LMWH )
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Intervention_Physical
graduated compression stockings ( GCS )
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Intervention_Physical
GCS alone
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Intervention_Pharmacological
LMWH+GCS
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Intervention_Physical
GCS
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Intervention_Pharmacological
LMWH
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Intervention_Physical
GCS
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Intervention_Physical
GCS
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Intervention_Pharmacological
LMWH
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Intervention_Pharmacological
LMWH
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Intervention_Pharmacological
LMWH
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Intervention_Physical
GCS
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Intervention_Physical
GCS .
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Intervention_Pharmacological
LMWH
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Outcome_Physical
prophylactic measures for venous thromboembolism ( VTE )
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Outcome_Physical
incidence of VTE
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Outcome_Adverse-effects
severe bleeding complications
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Outcome_Physical
occurrence rate of wound dehiscence
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Outcome_Other
efficacy
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Outcome_Physical
VTE post-operatively .
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Participant_Condition
post-operative patients with gynecologic cancer ]
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Participant_Condition
post-operative patients with gynecologic cancer
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Participant_Condition
gynecologic cancer
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Participant_Sample-size
247