78585
document
A comparison of once and twice daily atenolol for angina pectoris . We have studied the effects of four doses of atenolol in 11 patients with stable angina pectoris using a symptom-limited exercise test and angina diaries . The doses 100 mg twice daily and 50 mg , 100 mg and 200 mg once daily were given double-blind and randomised within patients following run-in on placebo . Measurements were made 12 hours after the last twice daily dose and 24 hours after the last once daily dose . Exercise tolerance was improved by 40-74 % and exercise duration before the onset of angina by 61-94 % ( P less than 0.01 ) . Maximal heart rate was reduced further by a total daily dose of 200 mg than by lower doses , but no extra benefit was derived by giving the drug twice daily . The largest increase in exercise tolerance was obtained during treatment with 50 mg once daily . Atenolol was shown to be an effective anti-anginal agent when given once daily , and there were no major differences between the doses studied .
78586
Intervention_Pharmacological
atenolol
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Intervention_Pharmacological
atenolol
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Intervention_Control
placebo
78589
Intervention_Pharmacological
Atenolol
78590
Outcome_Physical
Exercise tolerance
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Outcome_Physical
exercise duration before the onset of angina
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Outcome_Physical
Maximal heart rate
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Outcome_Physical
exercise tolerance
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Participant_Condition
angina pectoris
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Participant_Condition
11