88819
document
Thoracoscopic talc insufflation versus talc slurry for symptomatic malignant pleural effusion . BACKGROUND Talc has been generally accepted to be the most effective sclerosant for chemical pleurodesis , although the optimal route of administration remains unclear . METHODS We designed a prospective , randomized study to compare video-assisted thoracoscopic talc insufflation with bedside talc slurry in the treatment of malignant pleural effusion . From September 1993 to November 1995 , 57 patients were recruited and randomized to either video-assisted thoracoscopic talc insufflation under general anesthesia ( n = 28 ) or talc slurry by the bedside ( n = 29 ) . Patients with poor general condition ( Karnofsky score less than 30 % ) , poor pulmonary function ( forced expiratory volume in 1 second less than 0.5 L ) , or trapped lungs were excluded from this study . Five grams of purified talc was used for either video-assisted thoracoscopic talc insufflation or talc slurry . RESULTS There was no statistically significant difference between the two groups of patients with respect to age , sex ratio , chest drainage duration , postprocedural hospital stay , parenteral narcotics requirement , complications , or procedure failure ( ie , recurrence ) . CONCLUSIONS Video-assisted thoracoscopic talc insufflation has not been shown to be a superior approach compared with talc slurry in our study . Because the former demands more resources , we advocate that talc slurry should be considered as the procedure of choice in the treatment of symptomatic malignant pleural effusion in patients who do not have trapped lungs .
88820
Intervention_Pharmacological
Thoracoscopic talc insufflation
88821
Intervention_Pharmacological
talc slurry
88822
Intervention_Pharmacological
video-assisted thoracoscopic talc insufflation
88823
Intervention_Pharmacological
bedside talc slurry
88824
Intervention_Pharmacological
video-assisted thoracoscopic talc insufflation
88825
Intervention_Pharmacological
general anesthesia
88826
Outcome_Other
significant difference between the two groups of patients with respect to age , sex ratio , chest drainage duration , postprocedural hospital stay ,
88827
Outcome_Mental
parenteral narcotics requirement
88828
Outcome_Adverse-effects
complications
88829
Outcome_Other
procedure failure ( ie , recurrence )
88830
Participant_Condition
symptomatic malignant pleural effusion .
88831
Participant_Condition
malignant pleural effusion
88832
Participant_Sample-size
57
88833
Participant_Condition
poor general condition
88834
Participant_Condition
poor pulmonary function
88835
Participant_Condition
trapped lungs
88836
Participant_Condition
trapped lungs