76595
document
The additive analgesic efficacy of acetaminophen , 1000 mg , and codeine , 60 mg , in dental pain . In a double-blind , randomized , single-dose trial the analgesic contribution of acetaminophen , 1000 mg , and codeine , 60 mg , was determined . The study was a 2 X 2 factorial experiment in which 120 patients suffering from pain as a result of oral surgery rated their pain intensity and pain relief for up to 5 hours after a single dose of one of : 1000 mg acetaminophen , 60 mg codeine , 1000 mg acetaminophen plus 60 mg codeine , or placebo . The factorial analysis showed that both 1000 mg acetaminophen and 60 mg codeine made a statistically significant ( P less than 0.05 ) contribution to the analgesic effectiveness of the combination on all measures of efficacy ( sum of pain intensity differences , largest pain intensity difference , total pain relief , largest pain relief , and time to remedication ) . The incidence of adverse effects did not appear to differ among the treatments , including placebo .
76596
Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
codeine
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Intervention_Pharmacological
acetaminophen , 1000 mg
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Intervention_Pharmacological
codeine , 60 mg
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Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
acetaminophen plus 60 mg codeine
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Intervention_Control
placebo .
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Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
codeine
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Outcome_Pain
pain intensity
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Outcome_Pain
pain relief
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Outcome_Other
analgesic effectiveness
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Outcome_Pain
of the combination on all measures of efficacy
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Outcome_Pain
sum of pain intensity differences
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Outcome_Pain
largest pain intensity difference
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Outcome_Pain
total pain relief
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Outcome_Pain
largest pain relief
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Outcome_Pain
time to remedication
76614
Outcome_Adverse-effects
incidence of adverse effects
76615
Participant_Condition
dental pain
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Participant_Sample-size
120