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document
Primary glaucoma triple procedure in patients with primary open-angle glaucoma : the effect of mitomycin C in patients with and without prognostic factors for filtration failure . PURPOSE To investigate the effect of adjunctive mitomycin C on primary glaucoma triple procedure in patients with primary open-angle glaucoma with and without one or more of the prognostic factors for filtration failure of primary glaucoma triple procedure . Those factors include being of African-American race , having a preoperative intraocular pressure of 20 mm Hg or more on maximum tolerated medications , and being on two or more medications preoperatively . METHODS Study patients consisted of 197 consecutive patients with primary open-angle glaucoma who were randomly assigned to receive either no adjunctive mitomycin C ( 101 eyes of 101 patients ) or to receive adjunctive subconjunctival mitomycin C ( 96 eyes of 96 patients ) during the primary glaucoma triple procedure . Kaplan-Meier survival analysis comparisons were made between respective subgroups with and without prognostic indicators for filtration failures using a relatively stringent set of criteria for filtration success of primary glaucoma triple procedure . RESULTS There was no statistically significant ( P = .117 ) difference in filtration success of primary glaucoma triple procedure between the control and mitomycin C groups . Adjunctive mitomycin C significantly ( P < .05 ) improved the filtration outcome of the primary glaucoma triple procedure in the subgroups with each of the three prognostic factors for filtration failure of primary glaucoma triple procedure . On the other hand , in the subgroups without the prognostic factors , adjunctive mitomycin C did not significantly ( P > .05 ) change the filtration outcome of the primary glaucoma triple procedure . CONCLUSION These findings establish the basis for selective use of mitomycin C in patients with primary open-angle glaucoma undergoing primary glaucoma triple procedure .
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Intervention_Pharmacological
mitomycin C
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Intervention_Pharmacological
adjunctive mitomycin C
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Intervention_Control
no adjunctive mitomycin C ( 101 eyes of 101 patients )
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Intervention_Pharmacological
receive adjunctive subconjunctival mitomycin C ( 96 eyes of 96 patients ) during the primary glaucoma triple procedure
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Outcome_Other
effect
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Outcome_Other
effect
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Outcome_Mortality
Kaplan-Meier survival analysis comparisons
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Outcome_Physical
filtration success
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Outcome_Other
filtration
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Outcome_Physical
filtration outcome