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document
Variance in albumin loading in exchange transfusions . To assess the rationale of albumin priming prior to exchange transfusions , 42 hyperbilirubinemic infants who required exchange transfusions were randomly assigned to one of two groups . Group I consisted of 15 infants who were given intravenously 1 gm/kg of salt-poor human serum albumin one hour before the exchanges . Group II , which consisted of 27 infants , received simple exchanges . No statistical differences were found in variations in reserve albumin-binding capacity , bilirubin , albumin , or red cell bilirubin at pre and one-hour post albumin infusion in the primed infants . The amount of bilirubin removed per kilogram is directly correlated to plasma bilirubin concentration ( r=0.87 ) . No significant difference in efficiency on bilirubin removal was seen between the two groups . Beneficial effects of albumin therapy was apparent only in those infants with low RABC as determined by the sephadex gel filtration technique .
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Intervention_Pharmacological
albumin
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Intervention_Pharmacological
intravenously 1 gm/kg of salt-poor human serum albumin
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Outcome_Physical
amount of bilirubin removed per kilogram
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Outcome_Physical
plasma bilirubin concentration
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Outcome_Physical
efficiency on bilirubin removal
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Participant_Condition
42 hyperbilirubinemic infants who required exchange transfusions
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Participant_Age
15 infants