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document
High-dose weekly fractionation radiotherapy in advanced cancer of the uterine cervix . A trial comparing two different radiotherapy techniques and schedules in the treatment of 83 patients with advanced cancer of the uterine cervix ( stage IIIB ) employing external irradiation alone is described . The one technique , used routinely in this department , employed a conventional daily fractionation schedule while the other used a high-dose weekly fractionation regimen . The techniques are described . The aim of the trial was to compare the efficacy and morbidity of these two methods of treatment . Dose distribution curves in cross-section and midsagittal planes are shown and calculations or equivalent doses at various selected points using Ellis 's nominal single-dose formula are tabulated . The 2-year survival figures were 33 % for the daily fractionation technique and 22 % for the weekly regimen . Serious late complication rates were 6 % for the daily regimen and 22 % for the weekly schedule . These differences are not statistically significant . Late complication rates in the weekly fractionation regimen appeared to be lower than figures quoted by other authors . Local control within the irradiated volume was better in the group treated by the daily fractionation method .
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Intervention_Physical
High-dose weekly fractionation radiotherapy
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Intervention_Physical
external irradiation
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Outcome_Other
efficacy
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Outcome_Other
morbidity
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Outcome_Mortality
survival
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Outcome_Adverse-effects
Serious late complication rates
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Outcome_Adverse-effects
Late complication rates
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Participant_Condition
advanced cancer of the uterine cervix
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Participant_Sample-size
83