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document
Effect of intravenous fructose-1,6-diphosphate on myocardial contractility in patients with left ventricular dysfunction . STUDY OBJECTIVE To examine the effects of fructose-1,6-diphosphate on myocardial performance using nuclear scintigraphy . DESIGN Prospective , randomized , single-blind , parallel study . SETTING Urban teaching hospital clinical research center . PATIENTS Individuals with New York Heart Association functional class II-III heart failure ( mild to moderate ) . INTERVENTIONS Subjects received either intravenous fructose-1,6-diphosphate 125 mg/kg or normal saline 1.3 ml/kg every 12 hours over 10 minutes for four consecutive doses . Left ventricular performance was assessed by radionuclide ventriculography at baseline and within 60 minutes after the fourth infusion . Vital signs were monitored throughout the study period . MEASUREMENTS AND MAIN RESULTS Fructose-1,6-diphosphate resulted in a modest 7 % increase in left ventricular ejection fraction ( p < 0.05 ) . Peak ejection rate and peak diastolic filling rate did not change significantly . There were no changes in blood pressure or heart rate with either fructose-1,6-diphosphate or placebo . CONCLUSIONS Fructose-1,6-diphosphate produces a modest but significant increase in left ventricular ejection fraction in patients with mild to moderate heart failure .
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Intervention_Pharmacological
intravenous fructose-1,6-diphosphate
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Intervention_Pharmacological
fructose-1,6-diphosphate
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Intervention_Pharmacological
intravenous fructose-1,6-diphosphate 125 mg/kg
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Intervention_Control
normal saline
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Intervention_Physical
radionuclide ventriculography
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Intervention_Pharmacological
Fructose-1,6-diphosphate
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Intervention_Pharmacological
fructose-1,6-diphosphate
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Intervention_Control
placebo
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Intervention_Pharmacological
Fructose-1,6-diphosphate
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Outcome_Physical
myocardial contractility
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Outcome_Physical
myocardial performance
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Outcome_Physical
left ventricular ejection fraction
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Outcome_Physical
Peak ejection rate
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Outcome_Physical
peak diastolic filling rate
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
left ventricular ejection fraction
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Participant_Condition
left ventricular dysfunction
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Participant_Condition
New York Heart Association functional class II-III heart failure ( mild to moderate
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Participant_Condition
heart failure