6764
document
Valsartan alone or with a diuretic or ACE inhibitor as treatment for African American hypertensives : relation to salt intake . Previous clinical trials have demonstrated the important influence of ethnicity and dietary salt on the antihypertensive efficacy of drugs that block the renin angiotensin system . Angiotensin II receptor blockers are a new therapeutic entity that have not been widely studied in African American hypertensives , either alone , or in combination with other therapies such as diuretics or angiotensin converting enzyme inhibitors . We performed a pilot , prospective , open label , randomized design clinical trial to evaluate the effects of the angiotensin II receptor blocker valsartan ( 160 mg once a day ) on systolic and diastolic blood pressure in hypertensive African Americans ( n = 88 ) on a low salt ( 100 mEq Na+/day ) for 2 weeks and the same diet supplemented by 100 mEq Na+ for 4 weeks . After this evaluation , while continuing the Na+ supplementation , patients were randomized to valsartan 320 mg/day ( n = 28 ) , or the addition of hydrochlorothiazide ( HCTZ ) 12.5 mg/day ( n = 30 ) , or benazepril 20 mg/day to the valsartan 160 mg/day for an additional 6 weeks . Valsartan ( 160 mg/day ) lowered blood pressure significantly in African American patients on both low salt ( -6.4/-4.8 mm Hg : P < .001 ) and a high salt diet ( -4.9/-3.8 mm Hg : P = .01 ) . The high salt diet attenuated the antihypertensive effect slightly ( 1.6/1.3 mm Hg , P = not significant ) . When comparing the efficacy of the three randomized therapeutic regimens while on the Na+ supplement , the valsartan 160 mg/HCTZ 12.5 mg was the most effective therapy with an incremental reduction in blood pressure of -10.5/-6.9 mm Hg ( P < .01 ) , compared to valsartan 160 mg/day alone . Doubling the dose of valsartan to 320 mg incrementally lowered blood pressure by -3.8/-3.3 mm Hg ( P = not significant ) . The least effective approach was adding benazepril 20 mg/day to valsartan 160 mg/day with no incremental reduction in systolic blood pressure and diastolic blood pressure reduction of only 1.7 mm Hg ( P = not significant ) . We conclude that in our open label pilot study , the antihypertensive activity of valsartan is not significantly attenuated by supplemented salt diet in hypertensive African Americans . Moreover , adding a low dose of HCTZ appears to be the most effective strategy in enhancing the antihypertensive activity of this angiotensin II receptor blocker in contrast to either doubling the dose or adding an angiotensin converting enzyme inhibitor .
6765
Intervention_Pharmacological
inhibitor
6766
Intervention_Pharmacological
angiotensin II receptor blocker valsartan
6767
Intervention_Pharmacological
low salt ( 100 mEq Na+/day ) for 2 weeks and the same diet supplemented by 100 mEq Na+ for 4 weeks
6768
Intervention_Pharmacological
randomized to valsartan 320 mg/day ( n = 28 )
6769
Intervention_Pharmacological
addition of hydrochlorothiazide ( HCTZ ) 12.5 mg/day ( n = 30 )
6770
Intervention_Pharmacological
benazepril 20 mg/day to the valsartan 160 mg/day for an additional 6 weeks
6771
Outcome_Physical
systolic and diastolic blood pressure
6772
Outcome_Physical
blood pressure
6773
Outcome_Physical
antihypertensive effect
6774
Outcome_Physical
blood pressure
6775
Outcome_Physical
blood pressure
6776
Outcome_Physical
systolic blood pressure and diastolic blood pressure
6777
Participant_Condition
African American hypertensives
6778
Participant_Condition
hypertensive African Americans
6779
Participant_Sample-size
88
6780
Participant_Condition
hypertensive African Americans .