78638
document
Recurrent ulcer after successful treatment with cimetidine or antacid . This study was designed to compare the rates of duodenal ulcer healing and recurrence after treatment with cimetidine or antacid . Patients with endoscopically documented duodenal ulcer received cimetidine , 1200 mg daily , or Mylanta II , 7 oz daily , in a randomized , double-blind trial . For the 69 patients in each group who completed the healing phase of the trial , endoscopic ulcer healing was almost identical . At 2 , 4 , and 6 wk , the cumulative percent healed on antacid was 33 % , 64 % , and 80 % , and on cimetidine it was 25 % , 62 % , and 86 % . The 114 patients with healed ulcer were observed on no therapy and underwent additional endoscopy to detect recurrences when symptomatic or at 3 , 6 , and 12 mo . There was no difference in the frequency of recurrences between treatments . At 3 and 6 mo , the cumulative percentages of patients with recurrence were 29 % and 56 % after antacid therapy and 36 % and 55 % after cimetidine therapy . Some patient variables were associated with delayed ulcer healing or ulcer recurrence . These included sex , pain frequency , smoking , disease duration , and acid secretion .
78639
Intervention_Pharmacological
cimetidine
78640
Intervention_Pharmacological
antacid .
78641
Intervention_Pharmacological
cimetidine
78642
Intervention_Pharmacological
antacid
78643
Intervention_Pharmacological
cimetidine
78644
Intervention_Pharmacological
Mylanta II
78645
Intervention_Pharmacological
antacid
78646
Intervention_Pharmacological
cimetidine
78647
Intervention_Physical
antacid
78648
Intervention_Pharmacological
cimetidine
78649
Outcome_Physical
frequency of recurrences
78650
Outcome_Other
cumulative percentages of patients with recurrence
78651
Outcome_Physical
delayed ulcer healing
78652
Outcome_Physical
ulcer recurrence
78653
Participant_Condition
endoscopically
78654
Participant_Condition
duodenal ulcer
78655
Participant_Sample-size
69
78656
Participant_Sample-size
114
78657
Participant_Condition
ulcer