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document
Optimal dose of lignocaine for preventing pain on injection of propofol . The purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol . We conducted a prospective , randomized , double-blind trial on 310 patients undergoing anaesthesia . Patients were allocated to four groups according to the lignocaine dosage : group A ( control ) , no lignocaine ; group B , lignocaine 0.1 mg kg-1 ; group C , lignocaine 0.2 mg kg-1 ; group D , lignocaine 0.4 mg kg-1 . Our results showed that a dose of lignocaine 0.1 mg kg-1 significantly reduced the incidence of pain and that there was no improvement when the dose was increased .
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Intervention_Pharmacological
lignocaine
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Intervention_Pharmacological
lignocaine
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Intervention_Control
control
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Intervention_Pharmacological
lignocaine
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Intervention_Pharmacological
lignocaine
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Intervention_Pharmacological
lignocaine 0.4 mg kg-1
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Outcome_Pain
pain
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Outcome_Pain
pain
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Outcome_Pain
incidence of pain
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Participant_Sample-size
310 patients
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Participant_Condition
anaesthesia