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document
Clinical effects of buspirone in social phobia : a double-blind placebo-controlled study . BACKGROUND The results of open pilot studies suggest that the serotonin-1A ( 5-HT1A ) receptor agonist buspirone might be effective in social phobia . METHOD In the present study , the efficacy of buspirone was investigated in patients with social phobia using a 12-week double-blind placebo-controlled design . Thirty social phobic patients ( DSM-IV ) were treated with either buspirone 30 mg daily or placebo . Efficacy of treatment was measured using the Social Phobia Scale ( subscores anxiety and avoidance ) and the Hamilton Rating Scale for Anxiety . RESULTS Taking a reduction of 50 % or more on the Social Phobia Scale as a criterion for clinically relevant improvement , only 1 patient on buspirone and 1 on placebo were classified as responder to treatment . A subjective and clinically relevant improvement was reported by 4 patients ( 27 % ) on buspirone and 2 patients ( 13 % ) on placebo . There were no statistically significant differences between buspirone and placebo on any of the outcome measures . Generally speaking , buspirone was well tolerated . CONCLUSION The results of the study do not support the results of open studies , in which a reduction of social anxiety and social avoidance was reported in patients with social phobia treated with buspirone .
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Intervention_Pharmacological
buspirone
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Intervention_Pharmacological
serotonin-1A ( 5-HT1A ) receptor agonist buspirone
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Intervention_Pharmacological
buspirone
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
buspirone
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
buspirone
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Intervention_Control
placebo
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Intervention_Pharmacological
buspirone
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Outcome_Other
efficacy
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Outcome_Mental
Social Phobia Scale ( subscores anxiety and avoidance )
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Outcome_Mental
Hamilton Rating Scale for Anxiety
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Outcome_Other
reduction
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Outcome_Mental
Social Phobia Scale
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Outcome_Other
relevant improvement
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Outcome_Other
well tolerated
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Outcome_Mental
social anxiety and social avoidance
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Participant_Condition
social phobia
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Participant_Sample-size
Thirty
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Participant_Condition
social phobic patients ( DSM-IV )
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Participant_Condition
social phobia