48661
document
Relationship between baseline blood pressure parameters ( including mean pressure , pulse pressure , and variability ) and early outcome after stroke : data from the Tinzaparin in Acute Ischaemic Stroke Trial ( TAIST ) . BACKGROUND AND PURPOSE High blood pressure ( BP ) in acute stroke is associated independently with a poor outcome . Recent evidence suggests that other hemodynamic parameters may also be associated with outcomes following stroke . METHODS The relationship between baseline BP , heart rate , and other hemodynamic parameters , and early outcomes were assessed using data from TAIST trial . RESULTS Death or neurological deterioration at day 10 was associated , both in unadjusted and adjusted analyses , with systolic BP ( adjusted OR , 1.02 ; 95 % CI , 1.01-1.03 ) , mean arterial pressure ( OR , 1.02 ; 95 % CI , 1.01-1.04 ) , pulse pressure ( OR , 1.02 ; 95 % CI , 1.01-1.03 ) , and BP variability ( OR , 1.03 ; 95 % CI , 1.01-1.05 ) . Similar relationships were noted for deterioration alone , and recurrent stroke . CONCLUSIONS Early death or neurologic deterioration , deterioration , and recurrent stroke are associated independently with high systolic BP , mean arterial pressure , pulse pressure , and BP variability . These measures offer potential therapeutic targets for improving early outcome after acute ischemic stroke .
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Intervention_Pharmacological
Tinzaparin
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Intervention_Physical
therapeutic targets
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Outcome_Mortality
Death
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Outcome_Physical
neurological deterioration at day 10
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Outcome_Physical
systolic BP
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Outcome_Physical
mean arterial pressure
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Outcome_Physical
pulse pressure
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Outcome_Physical
BP variability
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Outcome_Physical
deterioration alone
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Outcome_Physical
recurrent stroke
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Outcome_Mortality
death
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Outcome_Physical
neurologic deterioration
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Outcome_Physical
deterioration
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Outcome_Physical
recurrent stroke
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Outcome_Physical
high systolic BP
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Outcome_Physical
mean arterial pressure
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Outcome_Physical
pulse pressure
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Outcome_Physical
BP variability
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Participant_Condition
stroke
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Participant_Condition
Acute Ischaemic Stroke
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Participant_Condition
High blood pressure
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Participant_Condition
acute stroke
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Participant_Condition
high systolic BP
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Participant_Condition
BP
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Participant_Condition
acute ischemic stroke