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document
Skin concentrations of thromboxane synthetase inhibitor after topical application with bioelastic membrane . Elevated thromboxane levels are associated with a number of disease states , including dermal pressure ulcers . When dazmegrel was orally administered to greyhound dogs wearing leg casts , it resulted in a sparring effect on the skin areas of potential pressure ulcer development . The objective of this research was to determine if bioelastic matrices could provide controlled release of thromboxane A2 synthetase inhibitor ( dazmegrel ) at tissue concentrations sufficient for inhibition of thromboxane synthesis . The animal used for these studies was the greyhound , which has thin skin , angular conformation , limited body fat and is predisposed to pressure ulcers similar to those occurring in humans . In vivo skin penetration studies showed that epidermal exposure to bioelastic thromboxane synthetase inhibitor ( TSI ) matrix resulted in local tissue concentrations of TSI sufficient for thromboxane synthetase inhibition . There were no significant differences between dazmegrel in the skin layers ( epidermis , dermis and subcutaneous layers ) on 1 , 7 and 14-day exposures .
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Intervention_Pharmacological
dazmegrel
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Outcome_Physical
Skin concentrations
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Outcome_Other
controlled release
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Outcome_Physical
local tissue concentrations of TSI
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Participant_Condition
greyhound dogs wearing leg casts