76771
document
Clofibrate and diabetes control in patients treated with oral hypoglycaemic agents . 1 . Twenty-two maturity-onset type diabetics treated with oral hypoglycaemic agents entered a single-blind crossover study using placebo ( periods A and C , 2 months each ) and clofibrate ( 2 g/day ; period B ; 2 months ) . 2 . In thirteen patients , under reasonably good control , clofibrate did not reduce fasting or post-prandial blood glucose , nor 24 h glycosuria ; no improvement was noted in the M-value , an index of diabetes control . 3 . In contrast , in nine patients , with poor diabetes control , clofibrate reduced 24 h glycosuria and significantly improved the M-value . 4 . In all patients , clofibrate therapy was associated with a significant 19-23 % reduction in plasma fibrinogen . 5 . It is suggested that addition of clofibrate may be useful in maturity-onset diabetics not adequately controlled by diet combined with oral hypoglycaemic agents .
76772
Intervention_Pharmacological
Clofibrate
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Intervention_Pharmacological
oral hypoglycaemic agents
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Intervention_Pharmacological
oral hypoglycaemic agents
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Intervention_Control
placebo
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Intervention_Pharmacological
clofibrate
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Intervention_Pharmacological
clofibrate
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Intervention_Pharmacological
clofibrate
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Intervention_Physical
clofibrate therapy
76780
Intervention_Pharmacological
clofibrate
76781
Intervention_Pharmacological
oral hypoglycaemic agents
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Outcome_Other
diabetes control
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Outcome_Physical
fasting or post-prandial blood glucose
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Outcome_Physical
24 h glycosuria
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Outcome_Physical
M-value
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Outcome_Physical
index of
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Outcome_Other
diabetes control
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Outcome_Physical
diabetes control
76789
Outcome_Physical
24 h glycosuria
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Outcome_Physical
M-value
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Outcome_Physical
plasma fibrinogen
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Participant_Condition
patients treated with oral hypoglycaemic agents
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Participant_Sample-size
Twenty-two
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Participant_Condition
type diabetics treated with oral hypoglycaemic agents
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Participant_Sample-size
thirteen