14674
document
[ Unstable angina : comparison of the effects of diltiazem and propranolol ] . PURPOSE To evaluate the effects of diltiazem and propranolol in patients with unstable angina . METHODS Fifty-six patients with unstable angina , mean age of 55.4 +/- 8.5 , 41 men and 15 women , were evaluated in a randomized , double-blind study of two groups of patients treated with diltiazem or propranolol at total daily doses of 180 mg and 120 mg respectively during the first 48 hours . After that the total daily doses was adjusted to 240 mg and 160 mg , respectively , until the 7th day . The first 48 hours , four times daily , clinical evaluation , CKMB data , ECG were obtained and two times daily until 7th day . A coronary arteriography was done on study entry . RESULTS A significative reduction of angina crisis number , duration , intensity and the number of sublingual nitrates doses were observed equally in both groups . The SAP , DAP , HR and RR did not show statistical differences between groups . Individual groups analysis showed significative reductions of SAP , DAP and HR in propranolol group . The CKMB data , ECG alterations and coronary arteriography characteristics were similar . CONCLUSION Both drugs were effective for the unstable angina treatment .
14675
Intervention_Pharmacological
diltiazem
14676
Intervention_Pharmacological
propranolol
14677
Intervention_Pharmacological
diltiazem
14678
Intervention_Pharmacological
propranolol
14679
Intervention_Pharmacological
diltiazem
14680
Intervention_Pharmacological
propranolol
14681
Intervention_Psychological
coronary arteriography
14682
Intervention_Pharmacological
propranolol
14683
Outcome_Physical
clinical evaluation
14684
Outcome_Other
CKMB data
14685
Outcome_Other
ECG
14686
Outcome_Physical
reduction of angina crisis number , duration , intensity
14687
Outcome_Other
number of sublingual nitrates doses
14688
Outcome_Physical
SAP , DAP , HR and RR
14689
Outcome_Physical
SAP , DAP and HR
14690
Outcome_Other
CKMB data
14691
Outcome_Other
ECG alterations
14692
Outcome_Physical
coronary arteriography