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Are 'leaky gut ' and behavior associated with gluten and dairy containing diet in children with autism spectrum disorders ? OBJECTIVES Studies have suggested a link between diet and behavior in children with autism spectrum disorders ( ASDs ) . Parental reports of behavioral changes upon exposure to gluten and/or casein are common in clinical practice . An association between diet type , intestinal permeability ( IP ) ( 'leaky gut ' ) , and behavior has been long proposed but not substantiated . We explored this possible association in this trial . METHODS This randomized double-blind , placebo-controlled study explored the effects of gluten and milk on IP and behavior in children with ASDs over a period of 4 weeks . IP assessed by lactulose : mannitol ( L/M ) sugar permeability test and behavior assessed by the Aberrant Behavior Checklist and Conners Parent Rating were measured . Gastrointestinal symptoms in both groups were also monitored . RESULTS Neither the L/M ratio nor behavioral scores were different between groups exposed to gluten/dairy or placebo . The changes observed were noted to be small and not clinically significant . DISCUSSION Our study although underpowered to show small differences does not support an association between dietary gluten/milk , IP , and behavioral changes in subjects with ASD .
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Intervention_Pharmacological
gluten
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Intervention_Pharmacological
dairy
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Intervention_Pharmacological
gluten and milk
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Outcome_Physical
'leaky gut '
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Outcome_Mental
behavior
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Outcome_Mental
behavior
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Outcome_Physical
intestinal permeability ( IP ) ( 'leaky gut ' )
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Outcome_Mental
behavior
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Outcome_Physical
lactulose : mannitol ( L/M ) sugar permeability test
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Outcome_Mental
Aberrant Behavior Checklist and Conners Parent Rating
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Outcome_Physical
Gastrointestinal symptoms
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Outcome_Mental
L/M ratio nor behavioral scores
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Outcome_Mental
behavioral changes
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Participant_Age
children
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Participant_Condition
autism spectrum disorders
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Participant_Age
children
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Participant_Condition
autism spectrum disorders ( ASDs )
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Participant_Age
children
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Participant_Condition
ASDs
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Participant_Condition
ASD