14168
document
Erythema migrans : comparison of treatment with azithromycin , doxycycline and phenoxymethylpenicillin . Azithromycin , doxycycline and phenoxymethylpenicillin were compared in a prospective , randomized study of 64 patients with typical erythema migrans . Twenty patients were treated with oral azithromycin , 250 mg bd for two days followed by 250 mg od for eight days , 21 patients were given phenoxymethylpenicillin 1 million IU tds for 14 days and 23 patients received doxycycline , 100 mg bd for 14 days . All patients were followed up for 24 months . There were no significant differences between the groups with respect to the persistence of cutaneous lesions after starting treatment ; the mean durations were 10.5 days in the penicillin group , 8.8 days in the doxycycline group and 8.6 days in the azithromycin group . There were statistically significant differences in terms of the resolution of associated local and/or systemic symptoms . The response time was shortest in patients treated with azithromycin . Two patients who received phenoxymethylpenicillin and two given doxycycline subsequently developed major manifestations of Lyme borreliosis ; these did not occur in patients receiving azithromycin . Although azithromycin has been shown to be effective in the treatment of erythema migrans , further studies will be needed to determine the optimal dosage and duration of therapy .
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
doxycycline
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Intervention_Pharmacological
phenoxymethylpenicillin
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Intervention_Pharmacological
Azithromycin
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Intervention_Pharmacological
doxycycline
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Intervention_Pharmacological
phenoxymethylpenicillin
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Intervention_Pharmacological
oral azithromycin
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Intervention_Pharmacological
phenoxymethylpenicillin
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Intervention_Pharmacological
doxycycline
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Intervention_Pharmacological
penicillin
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Intervention_Pharmacological
doxycycline
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
phenoxymethylpenicillin
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Intervention_Pharmacological
doxycycline
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
azithromycin
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Outcome_Physical
cutaneous lesions
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Outcome_Other
mean durations
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Outcome_Physical
resolution of associated local and/or systemic symptoms .
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Outcome_Other
response time
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Outcome_Physical
Lyme borreliosis
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Participant_Condition
Erythema migrans
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Participant_Sample-size
64
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Participant_Condition
erythema migrans