73515
document
Chlorthalidone does not increase the hypotensive effect of nifedipine in essential hypertensives : a crossover multicentre study . To determine whether the combination of nifedipine + chlorthalidone exerts an additive antihypertensive effect when compared with single-drug treatment , we studied 66 uncomplicated essential hypertensives , with diastolic blood pressure of greater than 100 and less than 115 mmHg . At the end of a 1-month washout placebo period , using a double-blind crossover design , the patients were randomly allocated to nifedipine ( 20 mg twice a day ) , chlorthalidone ( 25 mg once a day ) , the two drugs combined at the same doses and the corresponding placebo . Compared with the randomly allocated placebo , the three active treatments significantly reduced blood pressure without changing the heart rate or body weight . Both the absolute and percentage decreases in mean blood pressure induced by nifedipine and the combination compared with placebo were similar and significantly greater than those induced by chlorthalidone . Taken together , these data show that the combination of nifedipine + chlorthalidone does not exert any additive antihypertensive effect compared with nifedipine alone . This finding indicates that the combination of a dihydropyridine calcium antagonist + a thiazide diuretic is probably devoid of any particular clinical significance in the treatment of uncomplicated essential hypertensives .
73516
Intervention_Pharmacological
Chlorthalidone
73517
Intervention_Pharmacological
nifedipine
73518
Intervention_Pharmacological
nifedipine + chlorthalidone
73519
Intervention_Control
placebo
73520
Intervention_Pharmacological
nifedipine
73521
Intervention_Pharmacological
chlorthalidone
73522
Intervention_Control
placebo
73523
Intervention_Pharmacological
nifedipine
73524
Intervention_Control
placebo
73525
Intervention_Pharmacological
chlorthalidone
73526
Intervention_Pharmacological
nifedipine + chlorthalidone
73527
Intervention_Pharmacological
nifedipine
73528
Intervention_Pharmacological
dihydropyridine calcium antagonist + a thiazide diuretic
73529
Outcome_Physical
hypotensive effect
73530
Outcome_Physical
additive antihypertensive effect
73531
Outcome_Physical
blood pressure
73532
Outcome_Physical
heart rate or body weight .
73533
Outcome_Physical
mean blood pressure
73534
Outcome_Physical
additive antihypertensive effect
73535
Outcome_Physical
clinical significance
73536
Participant_Condition
crossover multicentre study .
73537
Participant_Condition
66 uncomplicated essential hypertensives , with diastolic blood pressure of greater than 100 and less than 115 mmHg .