34043
document
The effect of oral sodium acetate administration on plasma acetate concentration and acid-base state in horses . AIM Sodium acetate ( NaAcetate ) has received some attention as an alkalinizing agent and possible alternative energy source for the horse , however the effects of oral administration remain largely unknown . The present study used the physicochemical approach to characterize the changes in acid-base status occurring after oral NaAcetate/acetic acid ( NAA ) administration in horses . METHODS Jugular venous blood was sampled from 9 exercise-conditioned horses on 2 separate occasions , at rest and for 24 h following a competition exercise test ( CET ) designed to simulate the speed and endurance test of 3-day event . Immediately after the CETs horses were allowed water ad libitum and either : 1 ) 8 L of a hypertonic NaAcetate/acetic acid solution via nasogastric tube followed by a typical hay/grain meal ( NAA trial ) ; or 2 ) a hay/grain meal alone ( Control trial ) . RESULTS Oral NAA resulted in a profound plasma alkalosis marked by decreased plasma [ H+ ] and increased plasma [ TCO2 ] and [ HCO3- ] compared to Control . The primary contributor to the plasma alkalosis was an increased [ SID ] , as a result of increased plasma [ Na+ ] and decreased plasma [ Cl- ] . An increased [ Atot ] , due to increased [ PP ] and a sustained increase in plasma [ acetate ] , contributed a minor acidifying effect . CONCLUSION It is concluded that oral NaAcetate could be used as both an alkalinizing agent and an alternative energy source in the horse .
34044
Intervention_Pharmacological
sodium acetate
34045
Intervention_Pharmacological
Sodium acetate ( NaAcetate )
34046
Intervention_Physical
competition exercise test
34047
Intervention_Pharmacological
hypertonic NaAcetate/acetic acid solution
34048
Intervention_Pharmacological
typical hay/grain meal
34049
Intervention_Pharmacological
hay/grain meal alone
34050
Outcome_Adverse-effects
effect
34051
Outcome_Physical
plasma acetate concentration
34052
Outcome_Physical
acid-base state
34053
Outcome_Physical
acid-base status
34054
Outcome_Physical
Jugular venous blood
34055
Outcome_Physical
profound plasma alkalosis
34056
Outcome_Physical
plasma [ H+ ]
34057
Outcome_Physical
plasma [ TCO2 ] and [ HCO3- ]
34058
Outcome_Physical
plasma alkalosis
34059
Outcome_Physical
SID
34060
Outcome_Physical
[ Atot ]
34061
Outcome_Physical
[ PP ]
34062
Outcome_Physical
plasma [ acetate
34063
Outcome_Adverse-effects
acidifying effect
34064
Participant_Sample-size
9