8487
document
The impact of different doses of medroxyprogesterone acetate on mood symptoms in sequential hormonal therapy . The aim of this study was to compare adverse mood effects of two different doses of medroxyprogesterone acetate ( MPA ) during postmenopausal hormone replacement therapy ( HRT ) in women with and without a history of premenstrual syndrome ( PMS ) . The study was designed as a randomized double-blind cross-over study and included 36 postmenopausal women at three health care areas in northern Sweden . The women received 2 mg estradiol continuously during five 28-day cycles and 10 mg or 20 mg MPA sequentially for 12 days during each cycle . The main outcome measures were mood and physical symptoms noted on a daily rating scale . We found that physical symptoms did not differ between 10 and 20 mg MPA . Both women with a history of PMS and women without responded with more negative mood symptoms with the lower dose of MPA . In women with previous PMS the higher dose of MPA enhanced positive mood symptoms . With respect to mood and physical symptoms , the aim to lower MPA doses in HRT is unwarranted .
8488
Intervention_Pharmacological
medroxyprogesterone acetate
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Intervention_Pharmacological
sequential hormonal therapy
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Intervention_Pharmacological
medroxyprogesterone acetate ( MPA )
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Intervention_Pharmacological
2 mg estradiol
8492
Outcome_Mental
mood symptoms
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Outcome_Mental
mood effects
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Outcome_Mental
mood and physical symptoms noted on a daily rating scale
8495
Outcome_Mental
physical symptoms
8496
Outcome_Mental
mood symptoms
8497
Outcome_Mental
positive mood symptoms
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Outcome_Mental
mood and physical symptoms
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Participant_Condition
postmenopausal
8500
Participant_Sex
women
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Participant_Condition
premenstrual syndrome ( PMS ) .
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Participant_Sample-size
36
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Participant_Condition
postmenopausal
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Participant_Sex
women