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document
Lack of antihistamine properties of single dose cinnarizine in man . A simple way to study a histamine antagonist in man is to observe the effect it has on the magnitude of the skin reaction to intradermal histamine . The aim of the present study was to evaluate the antihistamine activity of single oral doses of 75 mg cinnarizine using 75 mg diphenhydramine as control , both being compared to placebo . The study was performed with two groups of 5 healthy subjects , each group receiving one of the active treatments or placebo randomly under blind conditions . All subjects received intradermal injections on the forearm of a 0.05 ml saline solution containing 5 micrograms of histamine before and at different times after drug intake . The histamine-induced wheal area was measured and , after drug administration , the percent decrease of the wheal area was calculated . Results showed that diphenhydramine produced a significant inhibition of the histamine-induced wheal size at 1.5 h which lasted up to 4 h after drug administration , reaching maximum inhibition at 2.5 h. After cinnarizine treatment no significant decrease of the histamine-induced wheal area was observed at any time .
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Intervention_Pharmacological
cinnarizine
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Intervention_Pharmacological
histamine .
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Intervention_Pharmacological
cinnarizine using
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Intervention_Pharmacological
diphenhydramine as control
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Intervention_Control
placebo .
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Intervention_Control
placebo
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Intervention_Control
saline solution
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Intervention_Pharmacological
diphenhydramine
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Intervention_Pharmacological
cinnarizine
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Outcome_Physical
wheal area
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Outcome_Other
inhibition of the
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Outcome_Physical
histamine-induced wheal size
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Outcome_Physical
histamine-induced wheal area
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Participant_Condition
man .