453
document
Protocol for the Multicenter Acute Stroke Trial -- thrombolysis study . The rationale for the Multicenter Acute Stroke Trial ( MAST ) is presented in a companion article appearing in this issue . Acute ischaemic stroke is the third major cause of death in developed countries , and a major cause of disability . Despite a very poor prognosis , no treatment has demonstrated an efficacy in lowering the mortality and disability resulting from stroke events . Thrombolysis has been proven to reduce mortality in myocardial infarction , and it has been shown able to induce recanalisation when administered to acute stroke patients . A recent meta analysis of small-sized studies suggests that thrombolysis could offer some benefit to stroke patients , by reducing the mortality and severe invalidity by 56 % ; these results need to be confirmed in adequately designed and sized studies .
454
Intervention_Pharmacological
Thrombolysis
455
Intervention_Pharmacological
thrombolysis
456
Outcome_Mortality
death
457
Outcome_Physical
disability
458
Outcome_Mortality
mortality
459
Outcome_Physical
disability
460
Outcome_Mortality
mortality in myocardial infarction
461
Outcome_Physical
recanalisation
462
Outcome_Mortality
mortality
463
Outcome_Physical
severe invalidity
464
Participant_Condition
acute stroke
465
Participant_Condition
stroke