61463
document
Bismuth subsalicylate in the treatment of gastritis due to Campylobacter pylori . Fifty patients completed an investigator-blind trial comparing bismuth subsalicylate , erythromycin ethylsuccinate , and placebo matched to the bismuth salt in the treatment of gastritis associated with Campylobacter pylori . C. pylori was cleared from 14 ( 77.8 % ) of 18 patients given locally active bismuth , from one ( 6.7 % ) of 15 patients given erythromycin , and from none of 17 patients given placebo . Gastritis resolved in 13 ( 81 % ) of 16 patients treated with bismuth but in only three of 13 receiving erythromycin and in none of 16 patients given placebo . Results of endoscopic examination showed greater improvement in patients cleared of C. pylori than in those with persistent infection . Heartburn improved in 50 % of patients who received bismuth compared with 17 % of those given placebo . The success of bismuth is probably due to its local antimicrobial activity . Erythromycin may have been inactivated by the low pH in the areas colonized with C. pylori . Relapse is less frequent when a combination of bismuth and an antimicrobial agent is used ; such a combination is characterized by local and systemic activity , stability at low pH , and good penetration into gastric mucus .
61464
Intervention_Pharmacological
Bismuth subsalicylate
61465
Intervention_Pharmacological
bismuth subsalicylate
61466
Intervention_Pharmacological
erythromycin ethylsuccinate
61467
Intervention_Control
placebo
61468
Intervention_Pharmacological
bismuth
61469
Intervention_Pharmacological
active bismuth
61470
Intervention_Pharmacological
erythromycin
61471
Intervention_Control
placebo
61472
Intervention_Pharmacological
bismuth
61473
Intervention_Pharmacological
erythromycin
61474
Intervention_Control
placebo
61475
Intervention_Pharmacological
bismuth
61476
Intervention_Control
placebo
61477
Intervention_Pharmacological
bismuth
61478
Intervention_Pharmacological
Erythromycin
61479
Intervention_Pharmacological
bismuth
61480
Outcome_Physical
Heartburn
61481
Outcome_Physical
local antimicrobial activity
61482
Outcome_Physical
Relapse
61483
Outcome_Physical
local and systemic activity
61484
Outcome_Physical
stability at low pH
61485
Outcome_Physical
good penetration into gastric mucus
61486
Participant_Condition
gastritis due to Campylobacter pylori . Fifty patients