75126
document
[ Propofol infusion for the maintenance of short-term anesthesia ] . The administration of propofol by infusion for maintenance of anesthesia has attracted much attention recently . We investigated the necessary infusion rate of propofol to maintain anesthesia for short surgical procedures without loss of the evident advantages of this substance . Forty unpremedicated female patients aged 18-59 , scheduled for minor gynecological procedures , were randomly assigned to four groups . Anesthesia was induced with 2.0 mg/kg propofol i.v . and simultaneously an infusion of 0.05 , 0.10 , 0.15 , or 0.20 mg propofol/kg per minute was started . The patients were breathing N2O/O2 with FIO2 33 % . Additional propofol was administered as a bolus of 10 to 20 mg when the patients moved . With 0.05 mg propofol/kg per minute all patients required additional bolus injections of propofol ; with 0.10 mg 8 patients , with 0.15 mg 5 patients , and with 0.20 mg 1 patient required bolus injection . Therefore , 0.15 mg/kg per minute can be considered as an approximate ED50 value . The total propofol consumption ( infusion + bolus ) increased from 0.102 +/- 0.028 ( +/- SD ) with the lowest infusion rate to 0.202 +/- 0.006 mg/kg per minute with the highest infusion rate and recovery time from 5.2 +/- 1.4 to 9.9 +/- 2.6 min . There was a significant correlation between propofol consumption and recovery time . After induction , arterial blood pressure decreased by systolic/diastolic 20/10-15 mmHg . With the low infusion rate , arterial pressure increased to its control value during operation ; it remained at the postinduction value with high infusion rates . Side-effects : 10 patients had salivation that in some instances lead to coughing , 9 reported pain at the injection site during induction , and 9 reported dreams of a pleasant nature . ( ABSTRACT TRUNCATED AT 250 WORDS )
75127
Intervention_Pharmacological
[ Propofol
75128
Intervention_Pharmacological
propofol
75129
Intervention_Pharmacological
propofol
75130
Intervention_Pharmacological
2.0 mg/kg propofol i.v .
75131
Intervention_Pharmacological
propofol/kg
75132
Intervention_Pharmacological
N2O/O2 with FIO2
75133
Intervention_Pharmacological
propofol
75134
Intervention_Pharmacological
propofol/kg
75135
Intervention_Pharmacological
propofol ;
75136
Intervention_Pharmacological
propofol
75137
Intervention_Pharmacological
propofol
75138
Outcome_Physical
anesthesia
75139
Outcome_Physical
total propofol consumption
75140
Outcome_Physical
infusion rate
75141
Outcome_Other
infusion rate
75142
Outcome_Other
recovery time
75143
Outcome_Physical
propofol consumption
75144
Outcome_Other
recovery time
75145
Outcome_Physical
arterial blood pressure
75146
Outcome_Physical
arterial pressure
75147
Participant_Condition
short-term anesthesia ]
75148
Participant_Condition
Forty unpremedicated female patients aged 18-59 , scheduled for minor gynecological procedures