80761
document
Cardiac and haemodynamic measurements in hypertensive pregnancy . 1 . Haemodynamic and left ventricular variables were determined by M-mode echocardiography in 21 normotensive and 36 hypertensive patients during the last trimester of pregnancy . 2 . Blood pressure of hypertensive patients was lowered by bed rest only , or by oxprenolol or methyldopa , but remained elevated . 3 . Cardiac output was raised in the last trimester of pregnancy in both normotensive and hypertensive patients . 4 . Left ventricular mass was increased in normal pregnancy , but displayed an exaggerated increase in hypertensive patients . 5 . Total peripheral resistance was inappropriately elevated in hypertensive pregnancy , except in the oxprenolol-treated group . 6 . There ws no reduction in heart rate or cardiac output in the group treated with beta-adrenoreceptor blocking agents . These factors , in combination with normal peripheral resistance , may contribute to the improvement in foetal outcome described in maternal hypertension of pregnancy treated with oxprenolol .
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Intervention_Pharmacological
oxprenolol or methyldopa
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Intervention_Pharmacological
beta-adrenoreceptor blocking agents
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Intervention_Pharmacological
oxprenolol .
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Outcome_Physical
Blood pressure
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Outcome_Physical
Cardiac output
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Outcome_Physical
Left ventricular mass
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Outcome_Physical
Total peripheral resistance
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Outcome_Physical
heart rate
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Outcome_Physical
cardiac output
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Participant_Condition
hypertensive pregnancy
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Participant_Sample-size
21
80773
Participant_Condition
normotensive
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Participant_Sample-size
36
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Participant_Condition
hypertensive
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Participant_Condition
hypertensive
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Participant_Condition
normotensive
80778
Participant_Condition
hypertensive
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Participant_Condition
hypertensive