6847
document
Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients . This study investigated the effects of beta2-adrenergic agonist therapy on heart rate variability ( HRV ) in adult asthmatic patients by using frequency domain measures of HRV . A randomized crossover design was used . Twenty adult patients with asthma were studied . All patients showed a mild-to-moderate decrease in baseline forced expiratory volume in one second . Any diseases that might have influenced the autonomic function were excluded . All patients had a complete physical examination and medical history that revealed no cardiovascular disease or medication . The study used 200 microg inhaled salbutamol and 500 microg inhaled terbutaline . HRV analysis was performed for each 5-min segment , 5 min before inhalation of the study drug and 5 , 10 , 15 , 20 , 25 and 30 min after inhalation . Total power ( TP : < 0.40 Hz ) , high-frequency power ( HF : 0.15-0.40 Hz ) , low-frequency power ( LF : 0.04-0.15 Hz ) and LF/HF ratio were calculated . The LF and LF/HF ratio increased and TP decreased at 5 , 10 , 15 and 20 min after the salbutamol and the terbutaline inhalation , HF did not change significantly after the salbutamol and terbutaline inhalation . Acute salbutamol and terbutaline inhalation produce similar effects on heart rate variability and increase sympathetic modulation in the cardiac autonomic activity .
6848
Intervention_Pharmacological
salbutamol and terbutaline
6849
Intervention_Pharmacological
beta2-adrenergic
6850
Intervention_Pharmacological
salbutamol
6851
Intervention_Pharmacological
inhaled terbutaline
6852
Intervention_Pharmacological
salbutamol
6853
Intervention_Pharmacological
terbutaline
6854
Intervention_Pharmacological
salbutamol
6855
Intervention_Pharmacological
terbutaline
6856
Intervention_Pharmacological
Acute salbutamol and terbutaline inhalation
6857
Outcome_Other
effects
6858
Outcome_Physical
heart rate variability
6859
Outcome_Physical
heart rate variability ( HRV )
6860
Outcome_Physical
forced expiratory volume in one second
6861
Outcome_Physical
Total power
6862
Outcome_Other
( TP : < 0.40 Hz )
6863
Outcome_Physical
high-frequency power
6864
Outcome_Other
( HF : 0.15-0.40 Hz )
6865
Outcome_Other
low-frequency power ( LF : 0.04-0.15 Hz )
6866
Outcome_Physical
LF/HF ratio
6867
Outcome_Physical
LF and LF/HF ratio
6868
Outcome_Physical
TP
6869
Outcome_Physical
HF
6870
Outcome_Physical
heart rate variability
6871
Outcome_Physical
sympathetic modulation
6872
Participant_Age
adult
6873
Participant_Condition
asthmatic
6874
Participant_Sample-size
Twenty