72597
document
The effectiveness of single-dose metronidazole therapy for patients and their partners with bacterial vaginosis . A randomized , placebo-controlled , double-blind clinical trial was performed to test the hypothesis that a 2-g single dose of metronidazole for male partners of women with bacterial vaginosis was more effective than placebo in improving cure rate and decreasing recurrence rate . In addition , the effectiveness of a 2-g single dose of metronidazole was compared with a seven-day course of 500 mg of metronidazole twice a day in patients with bacterial vaginosis . Statistically significant benefits of partner treatment were noted in the initial cure rate by Gram-stained smear criteria ( P less than .01 ) and in percentage of women with symptoms eight weeks after initiating therapy ( P less than .05 ) . The seven-day course of metronidazole was superior to the single-dose regimen in the percentage of patients with clue cells and the percentage of patients with a positive " sniff " test at the first follow-up visit ; however , differences in the initial cure rate assessed by clinical criteria and Gram-stained smear criteria were not statistically significant between the two patient treatment regimens . Recurrence rates by Gram-stained smear criteria between patient and partner treatment groups at five and eight weeks after initiation of treatment were also not significantly different between the two patient regimens . Single-dose metronidazole treatment of the sexual partner of women with bacterial vaginosis improves initial bacterial vaginosis cure rates . The seven-day course of metronidazole was not found by statistical analysis to be significantly superior to single-dose therapy when considering initial cure rates by clinical or Gram-stained smear criteria or recurrence rates . ( ABSTRACT TRUNCATED AT 250 WORDS )
72598
Intervention_Pharmacological
metronidazole
72599
Intervention_Control
placebo-controlled
72600
Intervention_Pharmacological
metronidazole
72601
Intervention_Pharmacological
single dose of metronidazole
72602
Intervention_Pharmacological
seven-day course of 500 mg of metronidazole
72603
Intervention_Pharmacological
metronidazole
72604
Outcome_Physical
initial cure rate assessed by clinical criteria and Gram-stained smear criteria
72605
Outcome_Physical
Recurrence rates by Gram-stained smear criteria
72606
Outcome_Physical
bacterial vaginosis cure rates