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document
A comparative study of administration methods of granisetron injection used to treat nausea/vomiting induced by cancer chemotherapy without cisplatin in tumors of hematopoietic organs . Keihanshin Study Group of Hematological Malignancies . PURPOSE The antiemetic effect of granisetron injection at a dose of 40 microg/kg used in the treatment of nausea/vomiting induced by multidrug combined cancer chemotherapy excluding cisplatin in patients with tumors of hematopoietic organs was evaluated by comparing a 30-min infusion and a slow intravenous injection given over 30 s. METHODS A two-group random-allocation comparative study was performed with the cooperation of multiple institutions using a central registration system . RESULTS In the treatment of acute clinical symptoms , appetite was described as " similar to that during good health " by 61.1 % of patients ( 55/93 ) in the instillation group and by 47.3 % ( 44/93 ) in the slow injection group , a significant advantage in the infusion group . However , no significant differences in the number of episodes of vomiting , the severity of nausea or clinical efficacy were found . In the final clinical evaluation and assessment of usefulness based on the subjective judgement of physicians throughout the entire therapeutic period , no differences were discernible . No side effects were reported for either method and there was no indication of a sex difference concerning efficacy . However , the efficacy in patients with an anemic tendency was slightly inferior . CONCLUSIONS The maintenance of appetite during the administration of anticancer drugs is very important to maintain patients ' daily activities and quality of life . The present results support the usefulness of infusion of granisetron as an administration method during chemotherapy for malignant hemopathy .
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Intervention_Pharmacological
granisetron injection
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Intervention_Pharmacological
granisetron injection
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Intervention_Pharmacological
multidrug combined cancer chemotherapy excluding cisplatin
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Intervention_Pharmacological
granisetron
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Outcome_Physical
appetite
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Outcome_Adverse-effects
number of episodes of vomiting , the severity of nausea
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Outcome_Other
clinical efficacy
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Outcome_Other
efficacy in patients
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Participant_Condition
tumors of hematopoietic organs .
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Participant_Condition
patients with tumors of hematopoietic organs
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Participant_Condition
multiple institutions using a central registration system