54829
document
[ Effects of shuxuening injection on the levels of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in acute exacerbated chronic obstructive pulmonary disease patients ] . OBJECTIVE To observe the effects of Shuxuening Injection ( SI ) on the levels of serum matrix metalloproteinase-9 ( MMP-9 ) and tissue inhibitor of metalloproteinase ( TIMP-1 ) in acute exacerbated chronic obstructive pulmonary disease ( COPD ) patients . METHODS Seventy-nine patients with acute exacerbated COPD were randomly assigned to the treatment group ( 39 cases ) and the control group ( 40 cases ) . Routine therapies for COPD were given to patients in the control group , while 15 mL SI was given to those in the treatment group by intravenous dripping , twice daily for total 14 days . The forced expiratory volume in one second ( FEV1 ) and forced vital capacity ( FVC ) were detected by Spirometer . The FEV1/FVC ( % ) and the FEV1 % were calculated . The levels of serum MMP-9 and TIMP-1 were detected using ELISA before and after treatment , and compared with 20 healthy subjects as the control . RESULTS The FEV1 , FVC , FEV1/FVC ( % ) , and FEV1 % were significantly improved after treatment in the treatment group when compared with before treatment and with the control group ( P < 0.05 , P < 0.01 ) . When compared with before treatment and with the control group , the levels of serum MMP-9 , TIMP-1 , and the ratio of MMP-9/TIMP-1 decreased more significantly in the treatment group after treatment ( P < 0.01 ) . Correlation analyses showed that obvious negative correlation existed between the levels of serum MMP-9 and TIMP-1 and FEV1/FVC ( % ) ( r = -0.677 , -0.629 , P < 0.01 ) . Obvious negative correlation existed between the levels of serum MMP-9 and TIMP-1 and FEV1 % ( r = -0.562 , -0.661 , P < 0.01 ) . Furthermore , obvious negative correlation also existed between the ratio of MMP-9/ TIMP-1 and FEV1 % , as well as FEV1/FVC ( % ) ( r = -0.732 , -0.891 , P < 0.01 ) . CONCLUSIONS SI could improve the pulmonary ventilation function of acute exacerbated COPD patients . One of its mechanisms might be correlated with lowering the serum levels of MMP-9 and TIMP-1 , and correcting the imbalance of MMP-9/TIMP-1 .
54830
Intervention_Pharmacological
shuxuening injection
54831
Intervention_Pharmacological
Shuxuening Injection ( SI )
54832
Intervention_Control
Routine therapies for COPD
54833
Intervention_Pharmacological
15 mL SI
54834
Intervention_Physical
forced expiratory volume in one second ( FEV1 ) and forced vital capacity ( FVC ) were detected by Spirometer
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Intervention_Pharmacological
SI
54836
Outcome_Physical
serum matrix metalloproteinase-9
54837
Outcome_Physical
tissue inhibitor of metalloproteinase-1
54838
Outcome_Physical
serum matrix metalloproteinase-9 ( MMP-9 )
54839
Outcome_Physical
tissue inhibitor of metalloproteinase ( TIMP-1 )
54840
Outcome_Physical
forced expiratory volume in one second ( FEV1 )
54841
Outcome_Physical
forced vital capacity ( FVC )
54842
Outcome_Physical
serum MMP-9
54843
Outcome_Physical
TIMP-1
54844
Outcome_Physical
FEV1 , FVC , FEV1/FVC ( % ) , and FEV1 %
54845
Outcome_Physical
serum MMP-9 , TIMP-1 , and the ratio of MMP-9/TIMP-1
54846
Outcome_Physical
serum MMP-9 and TIMP-1 and FEV1/FVC ( % )
54847
Outcome_Physical
serum MMP-9 and TIMP-1 and FEV1 %
54848
Participant_Condition
acute exacerbated COPD patients .