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document
Pharmacokinetics of azithromycin in lung tissue , bronchial washing , and plasma in patients given multiple oral doses of 500 and 1000 mg daily . The present study compares the pharmacokinetics of azithromycin in plasma , lung tissue , and bronchial washing after oral administration of 500 mg ( standard dose ) versus 1000 mg daily for 3 days . Samples were taken during surgery for lung resection at various time points up to 204 h after the last drug dose , and azithromycin levels were analyzed by HPLC method . Azithromycin was widely distributed within the lower respiratory tract ; sustained concentrations of the drug were detectable at the last sampling time ( 204 h ) in lung tissue and bronchial washing , with long terminal half-lives of 132.86 and 74.32 h at 500 mg daily and 133.32 and 70.5 h at 1000 mg daily , respectively . Doubling the drug dose resulted in a remarkable increase in lung area under the curve ( AUC , 1318 hx microg g ( -1 ) vs 2502 hx microg g ( -1 ) ) and peak tissue concentration ( 9.13+/-0.53 microg g ( -1 ) vs 17.85+/-2.4 microg g ( -1 ) ) . In addition to this , enhanced azithromycin penetration from plasma into bronchial secretion and lung tissue was evidenced by the increase in the ratio of AUC ( bronchial washing ) versus AUC ( plasma ) ( 2.96 vs 5.27 at 500 and 1000 mg , respectively ) and AUC ( lung ) versus AUC ( plasma ) ( 64.35 vs 97.73 at 500 and 1000 mg , respectively ) . In conclusion , the exposure of lung and bronchial washing to azithromycin is increased by doubling the dose , which results in favorable pharmacokinetic profile of the drug in the lower respiratory tract .
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
Azithromycin
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Intervention_Pharmacological
azithromycin
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Intervention_Pharmacological
azithromycin
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Outcome_Other
sustained concentrations of the drug
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Outcome_Physical
lung area under the curve
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Outcome_Physical
ratio of AUC ( bronchial washing ) versus AUC ( plasma )
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Outcome_Physical
AUC ( lung ) versus AUC ( plasma )
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Outcome_Other
pharmacokinetic profile