60138
document
Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder ( ADHD ) and associated behavior in children with autism spectrum disorders and ADHD symptoms . OBJECTIVE The purpose of this study was to examine the behavioral effects of four doses of psychostimulant medication , combining extended-release methylphenidate ( MPH ) in the morning with immediate-release MPH in the afternoon . METHOD The sample comprised 24 children ( 19 boys ; 5 girls ) who met American Psychiatric Association , Diagnostic and Statistical Manual of Mental Disorders , 4th ed . ( DSM-IV-TR ) criteria for an autism spectrum disorder ( ASD ) on the Autism Diagnostic Interview-Revised ( ADI-R ) and the Autism Diagnostic Observation Schedule ( ADOS ) , and had significant symptoms of attention-deficit/hyperactivity disorder ( ADHD ) . This sample consisted of elementary school-age , community-based children ( mean chronological age=8.8 years , SD=1.7 ; mean intelligence quotient [ IQ ] =85 ; SD=16.8 ) . Effects of four dose levels of MPH on parent and teacher behavioral ratings were investigated using a within-subject , crossover , placebo-controlled design . RESULTS MPH treatment was associated with significant declines in hyperactive and impulsive behavior at both home and school . Parents noted significant declines in inattentive and oppositional behavior , and improvements in social skills . No exacerbation of stereotypies was noted , and side effects were similar to those seen in typically developing children with ADHD . Dose response was primarily linear in the dose range studied . CONCLUSIONS The results of this study suggest that MPH formulations are efficacious and well-tolerated for children with ASD and significant ADHD symptoms .
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Intervention_Pharmacological
methylphenidate treatment
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Intervention_Pharmacological
extended-release methylphenidate ( MPH ) in the morning
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Intervention_Pharmacological
immediate-release MPH in the afternoon
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Intervention_Pharmacological
MPH
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Intervention_Pharmacological
MPH
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Outcome_Mental
ratings of attention-deficit/hyperactivity disorder ( ADHD )
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Outcome_Mental
associated behavior
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Outcome_Mental
behavioral effects
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Outcome_Other
parent and teacher behavioral ratings
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Outcome_Mental
hyperactive and impulsive behavior at both home and school
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Outcome_Mental
inattentive and oppositional behavior
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Outcome_Mental
social skills
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Outcome_Mental
exacerbation of stereotypies
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Outcome_Adverse-effects
side effects
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Outcome_Other
efficacious and well-tolerated
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Participant_Age
children
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Participant_Condition
autism spectrum disorders and ADHD symptoms
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Participant_Sample-size
24
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Participant_Sample-size
19
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Participant_Sex
boys
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Participant_Sample-size
5
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Participant_Sex
girls
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Participant_Age
elementary school-age
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Participant_Age
age=8.8 years
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Participant_Age
children
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Participant_Condition
ASD
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Participant_Condition
significant ADHD symptoms