67150
document
A comparison of multiphasic oral contraceptives containing norgestimate or desogestrel in acne treatment : a randomized trial . OBJECTIVE This study aimed to compare the effectiveness and safety of triphasic combined oral contraceptives ( OCs ) containing ethinyl estradiol ( EE ) and norgestimate ( NGM ) and biphasic combined OCs containing EE and desogestrel ( DSG ) in the treatment of mild to moderate acne . STUDY DESIGN This was an investigator-blinded , randomized , parallel group trial conducted at 3 centers in Thailand . Female subjects 18-45 years old were assigned to one or the other OCs and evaluated for efficacy and safety parameters at the baseline visit and after 1 , 3 and 6 months of treatment . RESULTS Among 201 randomized subjects , data from 93 subjects in the EE/NGM group and 95 subjects in the EE/DSG group were analyzed . After 6 months of treatment with EE/NGM and EE/DSG , no differences between formulations were found for the decrease in total acne lesion counts ( 74.4 % vs. 65.1 % , respectively , p=.070 ) or facial improvement score . More women using EE/NGM showed a decrease in severity of facial seborrhea than those using EE/DSG ( p=.005 ) . No changes in weight were noted in either group as compared to baseline . CONCLUSION Multiphasic OCs containing EE/NGM and EE/DSG provided comparable efficacy and tolerability in the treatment of acne . However , EE/NGM had a more beneficial effect on facial seborrhea reduction than EE/DSG . IMPLICATIONS EE/NGM and EE/DSG are multiphasic OCs , which were shown to be clinically equally effective for mild to moderate facial acne , and the multiphasic combined OC with NGM was more effective for women with facial seborrhea . Clinicians may apply the results of this study when considering treatment options for facial acne and seborrhea .
67151
Intervention_Pharmacological
multiphasic oral contraceptives
67152
Intervention_Pharmacological
norgestimate
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Intervention_Pharmacological
desogestrel
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Intervention_Pharmacological
triphasic combined oral contraceptives ( OCs )
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Intervention_Pharmacological
ethinyl estradiol ( EE ) and norgestimate ( NGM )
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Intervention_Physical
biphasic combined OCs containing EE and desogestrel ( DSG )
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Intervention_Physical
EE/NGM
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Intervention_Physical
EE/DSG
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Intervention_Physical
EE/NGM and EE/DSG
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Intervention_Physical
EE/NGM
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Intervention_Pharmacological
EE/DSG
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Intervention_Physical
OCs
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Intervention_Physical
EE/NGM and EE/DSG
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Intervention_Physical
EE/NGM
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Intervention_Physical
EE/DSG
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Intervention_Physical
EE/NGM and EE/DSG
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Intervention_Physical
multiphasic OCs
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Outcome_Physical
acne
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Outcome_Physical
decrease in total acne lesion counts
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Outcome_Physical
facial improvement score
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Outcome_Physical
severity of facial seborrhea
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Outcome_Physical
changes in weight
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Outcome_Other
efficacy and tolerability
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Outcome_Physical
facial seborrhea