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document
[ Clinical and experimental research of Epimedium brevicornum in relieving neuroendocrino-immunological effect inhibited by exogenous glucocorticoid ] . OBJECTIVE To study protective effect of Epimedium brevicornum ( EB ) on hypothalamus-pituitary-adrenal-thymus ( HPAT ) axis inhibited by exogenous glucocorticoid . METHODS In clinical research , variation of cortisol , adrenocorticotrophin ( ACTH ) , lymphocyte proliferative reaction were observed before and after medication in 65 patients took prednisone , and were randomly divided into Fufang prednisone group ( mixture of prednisone and EB ) and prednisone group . An experimental model of HPAT axis inhibited by corticosterone ( CORT ) was established to observe the effect of EB on relevant indices of HPAT axis . RESULTS The level of ACTH and CORT in plasma decreased and lymphocyte proliferative reaction reduced in patients ( P < 0.05 ) . In experimental study , monoaminic transmitters activated in hypothalamus ; weight of pituitary , adrenal and thymus decreased ; number of CRH positive neurons in hypothalamic paraventricular nucleus , CRH positive neurofibrilin median eminence and anterior pituitary ACTH positive secretory cells decreased ; adrenal fasciculate zone and thymus cortex atrophies ; NK cell cytotoxicity and the level of IL-2 and gamma-IFN which were produced by lymphocytes reduced in CORT-rats ( P < 0.05 ) . There were significant difference between Fufang prednisone group ( clinical research ) or EB group ( experimental research ) and CORT control groups , P < 0.05 . CONCLUSION EB could relieve neuroendocrino-immunological effect inhibited by exogenous glucocorticoid .
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Intervention_Pharmacological
Epimedium brevicornum
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Intervention_Pharmacological
Epimedium brevicornum ( EB )
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Intervention_Pharmacological
prednisone
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Intervention_Pharmacological
Fufang prednisone group ( mixture of prednisone and EB )
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Intervention_Pharmacological
prednisone group
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Outcome_Physical
neuroendocrino-immunological effect
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Outcome_Physical
level of ACTH and CORT in plasma
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Outcome_Physical
lymphocyte proliferative reaction
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Outcome_Physical
monoaminic transmitters
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Outcome_Physical
weight of pituitary , adrenal and thymus
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Outcome_Physical
number of CRH positive neurons in hypothalamic paraventricular nucleus , CRH positive neurofibrilin median eminence and anterior pituitary ACTH positive secretory cells
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Outcome_Physical
adrenal fasciculate zone and thymus cortex atrophies
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Outcome_Physical
NK cell cytotoxicity and the level of IL-2 and gamma-IFN
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Outcome_Physical
neuroendocrino-immunological effect
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Participant_Condition
neuroendocrino-immunological effect
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Participant_Sample-size
65