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document
A controlled trial of extended radical versus radical mastectomy . Ten-year results . In view of increasing debate over possible benefit of more complete surgery compared to conservative procedures , a randomized controlled trial contrasting the then standard Halsted radical ( RDL ) operation with the more complete extended radical ( EXT ) mastectomy was initiated in 1973 . Between November 1973 and July 1982 , 123 women younger than 70 years of age and at clinical Stages I and II were enrolled . Of the total series , 112 were treated by the same surgeon and confirmed pathologically as having invasive mammary carcinoma . In this more homogeneous subgroup , the 10-year survival rates ( and standard errors ) were for RDL , 60 % ( +/- 7 % ) and for EXT , 74 % ( +/- 6 % ) ( P value for comparison of survival curves = 0.13 ) . In patients from this subgroup with central-medial tumors , comprising 62 % of the total , survival after RDL at 10 years was 60 % ( +/- 8 % ) , and after EXT 86 % ( +/- 6 % ) ( P = 0.025 ) . In the remaining patients with lateral tumors , survival rates were unaffected by treatment : 58 % ( +/- 13 % ) and 56 % ( +/- 11 % ) , respectively ( P = 0.62 ) . Comparison of a nonrandomized series of 266 RDL and 124 EXT patients treated between 1960 and 1978 found differences consistent with those of the randomized study , although not statistically significant .
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Intervention_Surgical
extended radical
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Intervention_Surgical
radical mastectomy
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Intervention_Surgical
standard Halsted radical ( RDL ) operation
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Intervention_Surgical
complete extended radical ( EXT ) mastectomy
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Outcome_Mortality
10-year survival rates
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Outcome_Mortality
survival
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Outcome_Mortality
survival rates
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Participant_Sample-size
123
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Participant_Sex
women
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Participant_Age
younger than 70 years of age
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Participant_Condition
at clinical Stages I and II
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Participant_Sample-size
112
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Participant_Condition
invasive mammary carcinoma
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Participant_Condition
lateral tumors