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document
Effects of omeprazole and amoxycillin on the human oral and gastrointestinal microflora in patients with Helicobacter pylori infection . Fourteen patients with Helicobacter pylori infection were treated with omeprazole capsules 20 mg and amoxycillin capsules 1000 mg twice daily for 14 days and 14 patients with omeprazole capsules 20 mg and placebo twice daily for 14 days . Samples from saliva , dental plaque and faeces and biopsies from antrum and corpus were analysed in order to determine the ecological changes in the normal microflora . Several microorganisms were affected by both treatment regimens . Two patients were colonised with enterobacteria in the oral cavity and stomach during the omeprazole plus amoxycillin treatment . A general increase in the number of microorganisms from gastric mucosa was observed in both treatment groups . A selection of resistant enterobacteria and an increase in beta-lactamase production was observed in the faecal samples during the omeprazole plus amoxycillin treatment . Eradication of H. pylori in the omeprazole-amoxycillin group was 50 % and in the omeprazole placebo group 0 % four weeks after treatment . No viable H. pylori were cultivated in the saliva , dental plaque or faecal samples . Treatment with omeprazole 20 mg and amoxycillin 1000 mg twice daily for 14 days altered the normal microflora in the oral , gastric and intestinal tract and antibiotic resistant microorganisms increased in numbers in the intestinal microflora .
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Intervention_Pharmacological
omeprazole
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Intervention_Pharmacological
amoxycillin
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Intervention_Pharmacological
omeprazole
89180
Intervention_Pharmacological
amoxycillin
89181
Intervention_Pharmacological
omeprazole
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Intervention_Control
placebo
89183
Intervention_Pharmacological
omeprazole plus amoxycillin
89184
Intervention_Pharmacological
omeprazole plus amoxycillin
89185
Intervention_Pharmacological
omeprazole-amoxycillin
89186
Outcome_Other
general increase in the number of microorganisms from gastric mucosa
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Outcome_Other
selection of resistant enterobacteria
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Outcome_Other
increase in beta-lactamase production
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Outcome_Other
Eradication of H. pylori in the omeprazole-amoxycillin group
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Outcome_Other
No viable H. pylori
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Outcome_Physical
saliva
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Outcome_Physical
dental plaque
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Outcome_Physical
faecal samples
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Outcome_Physical
intestinal microflora
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Participant_Condition
patients with Helicobacter pylori infection .
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Participant_Sample-size
Fourteen