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document
Comparison of enoxaparin and standard heparin in gynaecologic oncologic surgery : a randomised prospective double-blind clinical study . OBJECTIVE This study aimed to compare the haemorrhagic complications and efficacy of enoxaparin , a low molecular weight heparin ( LMWH ) , and conventional standard heparin ( SH ) in gynaecological oncologic surgery . MATERIALS METHODS A double blind , randomised trial was performed on 102 consecutive women undergoing gynaecologic cancer surgery with pelvic and paraaortic lymphadenectomy . The women were separated into those who were given 2,500 IU enoxaparin once daily and SH in a dose of 5,000 IU three times daily . The groups were analysed for intraoperative blood loss , drainage , transfusion requirements , perioperative haemoglobin decrease , wound haematoma , and clinical deep venous thrombosis . RESULTS The two groups were well matched for age , weight , and other factors , which could predispose to the development of deep venous thrombosis ( DVT ) and haemorrhage . No patient developed clinical significant DVT , wound haematoma or intra-abdominal bleeding . There was no significant difference in bleeding complications between the two regimens . The antiFXa level in the plasma was correlated strongly with patient weight . CONCLUSIONS A dose of 2,500 IU enoxaparin/day does not cause more bleeding complications than SH 5,000 IU three times daily when used to prevent thrombosis . However , the dose of enoxaparin must be adjusted to the patient 's weight .
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Intervention_Pharmacological
enoxaparin
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Intervention_Pharmacological
standard heparin
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Intervention_Pharmacological
enoxaparin
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Intervention_Pharmacological
standard heparin ( SH )
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Intervention_Pharmacological
enoxaparin
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Intervention_Pharmacological
SH
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Intervention_Pharmacological
enoxaparin/day
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Outcome_Physical
development of deep venous thrombosis ( DVT )
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Outcome_Physical
haemorrhage
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Outcome_Physical
DVT
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Outcome_Physical
wound haematoma
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Outcome_Physical
intra-abdominal bleeding
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Outcome_Physical
bleeding complications
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Outcome_Physical
antiFXa level
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Participant_Condition
gynaecologic oncologic surgery :