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Comparison on therapeutic effect of plasma exchange and intravenous immunoglobulin for Guillian-Barre syndrome . OBJECTIVES To observe and compare the clinical curative effect of the plasma exchange ( PE ) and intravenous immunoglobulin ( IVIg ) for Guillian-Barre Syndrome ( GBS ) . METHODS Overall , 64 adult patients with GBS for PE and IVIg treatment , respectively , and nerve function were observed pre-treatment and at 1 week/2 weeks after completion of treatment ; the blood immunoglobulin , complement , fibrinogen ( Fib ) and monocyte percentage ( MON % ) were detected simultaneously . RESULTS After PE treatment , nerve function defect appeared to improve better than the IVIg group and clinical effect was better than the IVIg group . Treatment effective rates of the two groups after 2 weeks , respectively , are 96 and 79 % . PE and IVIg can significantly reduce the GBS patients ' blood immunoglobulin IgG , IgA , IgM , C3 and C4 , but these were significantly lower in the PE group than in the IVIg group . Fib and MON % were significantly lower in the PE group than in the IVIg group . CONCLUSION Both PE and IVIg have a high response as therapy and are reasonable therapeutic options for GBS . However , PE treatment has a more significantly curative effect , as it can effectively improve symptoms and be helpful in the early rehabilitation of patients .
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Intervention_Physical
plasma exchange and intravenous immunoglobulin
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Intervention_Physical
plasma exchange ( PE )
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Intervention_Physical
intravenous immunoglobulin ( IVIg )
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Intervention_Physical
PE
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Intervention_Physical
IVIg
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Participant_Condition
Guillian-Barre syndrome .
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Participant_Condition
plasma exchange ( PE )
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Participant_Condition
intravenous immunoglobulin ( IVIg )
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Participant_Condition
Guillian-Barre Syndrome ( GBS )
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Participant_Sample-size
64
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Participant_Age
adult patients
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Participant_Condition
GBS for PE
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Participant_Condition
IVIg treatment
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Participant_Condition
nerve function
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Participant_Condition
reduce the GBS patients
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Participant_Condition
rehabilitation of patients