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document
Clinical efficacy of fluvoxamine and functional polymorphism in a serotonin transporter gene on childhood autism . We studied the correlation between response to fluvoxamine and serotonin transporter gene promoter region polymorphism ( 5-HTTLPR ) . Eighteen children with autistic disorder completed a 12-week double-blind , placebo-controlled , randomized crossover study of fluvoxamine . Behavioral assessments were obtained before and at 12 weeks of treatment . 5-HTTLPR ( long ( l ) or short ( s ) ) , was analyzed by the PCR method . Ten out of 18 patients responded to fluvoxamine treatment ; allele type analysis revealed that clinical global effectiveness was noted significantly more in the l allele than in the s allele . However , with respect to language use , a significant effectiveness was noted in the s allele . 5-HTTLPR may influence the individual responses to fluvoxamine administration .
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Intervention_Pharmacological
fluvoxamine
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Intervention_Pharmacological
fluvoxamine
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
fluvoxamine
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Intervention_Pharmacological
fluvoxamine
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Intervention_Pharmacological
fluvoxamine
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Outcome_Mental
Behavioral assessments
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Outcome_Other
allele type analysis
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Outcome_Mental
language use
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Participant_Age
childhood
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Participant_Condition
autism
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Participant_Sample-size
Eighteen
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Participant_Age
children
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Participant_Condition
autistic disorder