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document
Hexetidine ( 'Oraldene ' ) : a report on its antibacterial and antifungal properties on the oral flora in healthy subjects . A randomized , double-blind crossover trial , in 10 adult healthy subjects , was carried out to compare the antibacterial and antifungal activity of a 0.1 % solution of hexetidine with that of placebo . The pre-dosing oral flora of the subjects was assessed from saliva samples cultured for aerobic and anaerobic bacteria , as well as Candida albicans . Subjects then rinsed their mouths for 1 minute 3-times a day with 15 ml 0.1 % hexetidine or placebo , saliva samples being collected at 2 minutes , 30 minutes , 1 hour , 3 hours and 5 hours post-dosing . Dosing was continued for 8 consecutive days on each treatment with an intervening wash-out period of 1 week . Hexetidine reduced aerobic bacterial counts on Day 1 and Day 8 by a maximum of 83 % and 86 % , respectively , at 2 minutes post-dosing . The reductions were statistically significantly lower than placebo up to 1 hour post-dose on Day 1 and up to 3 hours post-dose on Day 8 . Similarly for anaerobic bacterial counts , 92 % and 88 % maximum reductions were recorded on Day 1 and Day 8 , which again were significantly lower than placebo for up to 3 hours post-dose . For Candida albicans , however , the maximum reduction was 91 % on the first day and 67 % on Day 8 , maintained for 30 minutes post-dosing . Although not eradicating completely aerobic and anaerobic bacteria , it is concluded that the substantial reduction in their numbers should prove clinically useful .
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Intervention_Pharmacological
Hexetidine ( 'Oraldene ' )
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Intervention_Pharmacological
0.1 % solution of hexetidine
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Intervention_Control
placebo
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Intervention_Pharmacological
hexetidine
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Intervention_Control
placebo
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Intervention_Pharmacological
Hexetidine
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Intervention_Control
placebo
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Outcome_Physical
antibacterial and antifungal properties
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Outcome_Physical
antibacterial and antifungal activity
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Outcome_Physical
aerobic bacterial counts
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Outcome_Physical
anaerobic bacterial counts
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Outcome_Physical
eradicating completely aerobic and anaerobic bacteria
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Participant_Condition
healthy
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Participant_Sample-size
10
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Participant_Age
adult
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Participant_Condition
healthy