29457
document
5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency . A review . Male pseudohermaphrodites ( MPHs ) with inherited 5 alpha-reductase deficiency and decreased dihydrotestosterone production have a global defect in 5 alpha-metabolism affecting both C19 androgen metabolism and C21 steroid metabolism . However , the decreased 5 alpha-reduction of testosterone to dihydrotestosterone is the only impaired steroid conversion to have clinical consequences , e.g. , ambiguous genitalia , impaired prostate differentiation and development , and decreased facial and body hair . The 5 alpha-steroid metabolite profile in the MPHs was compared with that of men with benign prostatic hyperplasia who were administered varying doses of the 5 alpha-reductase inhibitor finasteride . Finasteride was found to be a potent inhibitor of both C19 androgen and C21 5 alpha-steroid metabolism affecting both hepatic and peripheral 5 alpha-metabolism . The 5 alpha-steroid metabolite profile was strikingly similar to that of MPHs with inherited 5 alpha-reductase deficiency . The data suggest that a 5 alpha-reductase gene codes for an enzyme with affinity for multiple steroid substrates .
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Intervention_Pharmacological
finasteride-treated
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Intervention_Pharmacological
5 alpha-reductase inhibitor finasteride
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Intervention_Pharmacological
Finasteride
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Outcome_Physical
ambiguous genitalia , impaired prostate differentiation and development
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Outcome_Physical
decreased facial and body hair
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Outcome_Other
5 alpha-steroid metabolite profile
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Outcome_Physical
C19 androgen and C21 5 alpha-steroid metabolism
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Outcome_Other
hepatic and peripheral 5 alpha-metabolism
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Outcome_Physical
affinity for multiple steroid substrates .
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Participant_Condition
finasteride-treated subjects
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Participant_Condition
pseudohermaphrodites
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Participant_Condition
inherited 5 alpha-reductase deficiency
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Participant_Condition
Male pseudohermaphrodites ( MPHs ) with inherited 5 alpha-reductase deficiency and decreased dihydrotestosterone production
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Participant_Condition
men with benign prostatic hyperplasia