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document
Short-term pulmonary effects of total parenteral nutrition in children with cystic fibrosis . Indices of respiratory muscle strength , pulmonary function , and pulmonary diffusing capacity were measured in 11 malnourished children ( age 10 to 17 years ) with cystic fibrosis , before and after improvement of nutritional status with supplemental parenteral nutrients for 1 month . During this time , the children received 120 % of estimated energy requirements ( either 3.75 % or 22.5 % as lipid ) and amino acids 2.5 gm/120 kcal by central venous catheter , plus as much of their usual diet as desired . With nutritional supplementation , body weight , triceps skinfold thickness , and mid-arm muscle circumference increased ( mean 15 % , 62 % , and 95 % , respectively ) . Maximum inspiratory airway pressure also increased ( mean 29 % ; P less than 0.01 ) , suggesting improvement in respiratory muscle strength . However , none of the indices of pulmonary function improved . Pulmonary diffusing capacity did not change during parenteral nutrition regardless of the amount of parenteral energy intake supplied by lipid , but arterial oxygen saturation decreased ( mean of 93.5 % to 91.5 % ; P less than 0.005 ) . During the month following parenteral nutrition , weight , skinfold thickness , and mid-arm muscle circumference , but not MIP , decreased and arterial oxygen saturation returned to the initial value ( P less than 0.01 ) .
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Intervention_Physical
total parenteral nutrition
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Intervention_Physical
supplemental parenteral nutrients
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Intervention_Pharmacological
lipid
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Intervention_Other
)
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Intervention_Pharmacological
amino acids
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Outcome_Other
nutritional supplementation
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Outcome_Physical
body weight
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Outcome_Physical
triceps skinfold thickness
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Outcome_Physical
mid-arm muscle circumference
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Outcome_Physical
respiratory muscle strength
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Outcome_Physical
indices of pulmonary function
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Outcome_Physical
Pulmonary diffusing capacity
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Outcome_Mental
parenteral energy intake
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Outcome_Physical
arterial oxygen saturation
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Participant_Age
children
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Participant_Condition
cystic fibrosis
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Participant_Condition
malnourished
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Participant_Condition
cystic fibrosis