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document
Ovulation and follicular development associated with three low-dose oral contraceptives : a randomized controlled trial . OBJECTIVE To address the hypothesis that multiphasic oral contraceptives ( OCs ) increase rather than decrease the risk of functional ovarian cysts . METHODS In this single-center , randomized controlled study , women were assigned to a multiphasic pill , a lower-dose monophasic pill , a higher-dose monophasic pill , or nonsteroidal contraception . Forty volunteers were randomized ( ten each ) to three different pill regimens or to nonsteroidal contraception . During 6 months of treatment , follicular development was measured by vaginal ultrasonography and ovulation was indicated by serum progesterone levels . RESULTS The relative risk ( RR ) of developing a follicular structure greater than 30 mm in diameter during a cycle with the higher-dose monophasic pill was 0.5 ( 95 % confidence interval [ CI ] 0.1-1.9 ; P = .49 ) compared with the multiphasic pill . The risk with the lower-dose monophasic pill was comparable to that with the multiphasic pill ( RR 1.3 , 95 % CI 0.5-3.6 ; P = .56 ) . With the multiphasic pill , the maximum ovulation rate over 60 cycles was 1.7 per 100 cycles ( 95 % CI 0.0-8.9 ) . CONCLUSION This multiphasic pill more closely resembled the lower-dose monophasic pill than the higher-dose monophasic pill in its suppression of follicular development .
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Intervention_Pharmacological
low-dose oral contraceptives
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Intervention_Pharmacological
multiphasic oral contraceptives ( OCs )
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Intervention_Pharmacological
multiphasic pill
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Intervention_Pharmacological
a lower-dose monophasic pill
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Intervention_Pharmacological
higher-dose monophasic pill
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Intervention_Pharmacological
nonsteroidal contraception
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Intervention_Pharmacological
three different pill regimens
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Intervention_Pharmacological
nonsteroidal contraception
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Intervention_Pharmacological
monophasic pill
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Intervention_Pharmacological
monophasic pill
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Intervention_Pharmacological
multiphasic pill
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Intervention_Pharmacological
multiphasic pill
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Intervention_Pharmacological
multiphasic pill
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Intervention_Pharmacological
monophasic pill
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Intervention_Pharmacological
monophasic pill
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Outcome_Physical
risk of functional ovarian cysts .
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Outcome_Physical
follicular development
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Outcome_Physical
ovulation
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Outcome_Physical
relative risk ( RR ) of developing a follicular structure greater than 30 mm in diameter
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Outcome_Physical
risk with the lower-dose monophasic pill
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Outcome_Physical
maximum ovulation rate
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Outcome_Physical
suppression of follicular development .