29497
document
Effects of nifedipine and nitrendipine on insulin secretion in obese patients . Data on the influence of calcium antagonists on glucose tolerance and insulin release in humans are conflicting . The present double-blind , double-dummy , controlled trial was designed to investigate the effect of a short-term ( 7 days ) treatment with nitrendipine , 20 mg b.i.d . ; nitrendipine , 20 mg once daily ; or placebo on blood glucose and plasma insulin and C-peptide response to an intravenous glucose load in mildly or transiently hypertensive nondiabetic obese patients . No statistically significant differences were found in fasting glucose , insulin , and C-peptide , or in the glucose disappearance rate and in any of the parameters for insulin and C-peptide response after i.v . glucose , between the three groups of patients . However , a slight decrease in early insulin response to glucose was observed in the nifedipine and the nitrendipine groups . This study confirms that calcium antagonists have no clinically relevant effect on glucose homeostasis even if a slight alteration of insulin release after glucose load can not be ruled out .
29498
Intervention_Pharmacological
nifedipine
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Intervention_Pharmacological
nitrendipine
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Intervention_Pharmacological
nitrendipine , 20 mg b.i.d . ; nitrendipine , 20 mg once daily ; or placebo
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Outcome_Physical
insulin secretion
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Outcome_Physical
glucose tolerance
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Outcome_Physical
insulin release
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Outcome_Physical
blood glucose
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Outcome_Physical
plasma insulin
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Outcome_Physical
C-peptide response
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Outcome_Physical
fasting glucose
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Outcome_Physical
insulin
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Outcome_Physical
C-peptide
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Outcome_Mental
in the glucose disappearance rate and in any of the parameters for insulin and C-peptide response
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Outcome_Physical
early insulin response to glucose
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Outcome_Adverse-effects
clinically relevant effect
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Participant_Condition
obese
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Participant_Condition
mildly or transiently hypertensive nondiabetic obese