13699
document
Pre-medication with pronase reduces artefacts during endoscopic ultrasonography . BACKGROUND Gastric mucus usually induces artefacts during endoscopic ultrasonography . AIM To investigate the effectiveness of pre-medication with the proteolytic enzyme , pronase , before endoscopic ultrasonography . METHODS Out-patients scheduled for endoscopic ultrasonography were randomly assigned to oral pre-medication with the anti-foam agent , dimethylpolysiloxane , alone ( treatment A ; n = 29 ) , with dimethylpolysiloxane plus sodium bicarbonate ( treatment B ; n = 29 ) or with dimethylpolysiloxane , sodium bicarbonate and pronase ( treatment C ; n = 29 ) . All drinks were given about 10 min before the start of the procedure . After insertion of the endoscope , endoscopists recorded visibility scores before the procedure , imaging scores at endoscopic ultrasonography and the numbers of high-echo spots in the gastric cavity and on the gastric wall surface after the procedure . RESULTS Pre-medication with pronase ( treatment C ) significantly reduced ( both at P < 0.05 ) the visibility score ( score 4 , 46 % ) in comparison with that obtained for pre-medication without pronase ( 10 % for both treatments A and B ) . Treatment with pronase significantly reduced ( both at P < 0.05 ) the endoscopic ultrasonography score in the gastric cavity ( score 4 , 34 % ) in comparison with that found for treatments A ( 7 % ) and B ( 0 % ) . It also significantly reduced ( P < 0.05 ) the endoscopic ultrasonography score on the gastric wall surface ( score 4 , 14 % ) in comparison with that observed for treatment A ( 3 % ) . The numbers of high-echo spots in the gastric cavity and on the gastric wall surface were significantly less ( both at P < 0.001 ) for pre-medication with pronase ( treatment C ) than for pre-medication with treatments A and B . There were no complications associated with the solutions . CONCLUSIONS Pre-treatment with pronase reduced the artefacts during endoscopic ultrasonography .
13700
Intervention_Pharmacological
pronase
13701
Intervention_Physical
ultrasonography
13702
Intervention_Pharmacological
proteolytic enzyme
13703
Intervention_Pharmacological
pronase
13704
Intervention_Physical
endoscopic ultrasonography
13705
Intervention_Pharmacological
anti-foam agent
13706
Intervention_Pharmacological
dimethylpolysiloxane , alone
13707
Intervention_Pharmacological
dimethylpolysiloxane plus sodium bicarbonate
13708
Intervention_Pharmacological
pronase
13709
Intervention_Pharmacological
pronase
13710
Intervention_Pharmacological
pronase
13711
Intervention_Pharmacological
pronase
13712
Intervention_Pharmacological
pronase
13713
Outcome_Physical
artefacts
13714
Outcome_Physical
artefacts
13715
Outcome_Other
visibility score
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Outcome_Other
the endoscopic ultrasonography score
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Outcome_Other
endoscopic ultrasonography score
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Outcome_Physical
high-echo spots in the gastric cavity and on the gastric wall surface
13719
Outcome_Adverse-effects
no complications
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Outcome_Physical
artefacts