36588
document
[ No effect of spironolactone on bulimia nervosa symptoms ] . Some case reports mention that Spironolactone , a mineral corticoid antagonist and aldosterone antagonist , reduces binging in patients with bulimia nervosa . Therefore , we decided to study these findings by using a randomized , double-blind , placebo controlled study design . In one study arm , patients with bulimia nervosa were treated with 150 mg Spironolactone per day ; in the other arm , patients received a placebo for a total of 8 weeks . The target variables were the number of binges and the bulimia scale of the Eating Disorder Inventory . The study included 93 patients . The results show that the number of binges and the scores on the bulimia scale decreased somewhat , but this occurred in both groups . We were not able to show any significant statistical differences between the Spironolactone group and the placebo group . Additional evaluations , executed with data from the Symptom-Check-List ( SCL-90R ) and with other scales from the EDI-2 also showed no effect of Spironolactone . Therefore , a treatment with Spironolactone seems to have no effect on bulimia nervosa symptoms .
36589
Intervention_Pharmacological
spironolactone
36590
Intervention_Pharmacological
Spironolactone
36591
Intervention_Pharmacological
mineral corticoid antagonist
36592
Intervention_Pharmacological
aldosterone antagonist
36593
Intervention_Control
placebo
36594
Intervention_Pharmacological
150 mg Spironolactone per day
36595
Intervention_Control
placebo
36596
Intervention_Pharmacological
Spironolactone
36597
Intervention_Pharmacological
Spironolactone
36598
Intervention_Pharmacological
Spironolactone
36599
Outcome_Other
No effect
36600
Outcome_Mental
binging
36601
Outcome_Mental
number of binges
36602
Outcome_Mental
bulimia scale of the Eating Disorder Inventory
36603
Outcome_Mental
number of binges and the scores on the bulimia scale
36604
Outcome_Other
significant statistical differences
36605
Outcome_Mental
Symptom-Check-List ( SCL-90R )
36606
Outcome_Other
no effect
36607
Participant_Condition
bulimia nervosa
36608
Participant_Condition
bulimia nervosa
36609
Participant_Sample-size
93