17947
document
Helicobacter pylori eradication in children and adolescents by a once daily 6-day treatment with or without a proton pump inhibitor in a double-blind randomized trial . AIM To evaluate two simplified Helicobacter pylori eradication treatment alternatives for children and adolescents . METHODS Study subjects were identified by enzyme-linked immunosorbent assay and immunoblot in a family screening project . Helicobacter pylori infected 10-21 year olds were offered treatment , individuals with abdominal pain underwent upper endoscopy and those with peptic ulcers were excluded . Participants were randomized to either azithromycin 500 mg daily and tinidazole 500 mg two tablets daily in combination with lansoprasole 30 mg daily for 6 days ( ATL-group ) or with placebo ( ATP-group ) . Urea Breath Test was performed at inclusion and after a minimum of 6 weeks after end of therapy . RESULTS In total , 131 individuals were randomized , of whom 31 ( 24 % ) had undergone upper endoscopy . Full compliance was achieved in 93 % ( 122 of 131 ) . The intention-to-treat eradication rate was 67 % ( 44 of 66 ) and 58 % ( 38 of 65 ) for the ATL- and the ATP-group , respectively . CONCLUSION The double-blind randomized clinical trial did not identify a simplified , successful once daily H. pylori treatment for children and adolescents . Thus , twice daily proton pump inhibitor ( PPI ) -based triple therapies for 7 days remain as the choice of treatment in children . Further , powerful and controlled studies are needed to elucidate the best treatment strategies for H. pylori eradication in this age group .
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Intervention_Pharmacological
treatment with or without a proton pump inhibitor
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Intervention_Pharmacological
azithromycin 500 mg daily and tinidazole 500 mg two tablets daily in combination with lansoprasole 30 mg daily for 6 days ( ATL-group )
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Intervention_Pharmacological
placebo ( ATP-group )
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Intervention_Physical
Urea Breath Test
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Outcome_Physical
Helicobacter pylori eradication
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Outcome_Physical
Helicobacter pylori eradication
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Outcome_Mental
Full compliance
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Outcome_Other
intention-to-treat eradication rate
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Participant_Condition
Helicobacter pylori eradication in
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Participant_Age
children
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Participant_Condition
and
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Participant_Age
adolescents
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Participant_Age
children
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Participant_Age
adolescents
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Participant_Condition
Helicobacter pylori
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Participant_Age
10-21
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Participant_Condition
abdominal pain
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Participant_Condition
peptic ulcers
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Participant_Sample-size
131
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Participant_Sample-size
31 ( 24 % )
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Participant_Age
children
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Participant_Age
adolescents
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Participant_Age
children