89330
document
Temporal variation in the effects of ophthalmic timolol on cardiovascular and respiratory functions in healthy men . This study examined the effects of ophthalmic timolol and time of administration on cardiovascular and respiratory functions in healthy young male volunteers . Eight participants ( mean age +/- standard deviation , 22 +/- 0.9 years ) received either 50 microL of 0.5 % timolol or placebo in the lower conjunctival sacs of both eyes in the morning or evening . Intraocular pressure , blood pressure , heart rate , and respiratory functions , including percent forced expiratory volume in 1 second and peak expiratory flow rate , were then measured for 3 hours after drug administration . Timolol reduced intraocular pressure and cardiovascular function at both administration times . However , a timolol-induced reduction in respiratory function was observed only in the evening : percent forced expiratory volume in 1 second , peak expiratory flow rate , and expiratory flow rate at 75 % vital capacity were reduced by 3 % , 7 % , and 12 % , respectively , 3 hours after administration . These results indicate that ophthalmic timolol reduces cardiovascular and respiratory functions in healthy young male subjects and that bronchial sensitivity to timolol differs between morning and evening .
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Intervention_Pharmacological
ophthalmic timolol
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Intervention_Pharmacological
ophthalmic timolol
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Intervention_Pharmacological
timolol
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Intervention_Control
placebo
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Intervention_Pharmacological
Timolol
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Intervention_Pharmacological
timolol-induced
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Intervention_Pharmacological
ophthalmic timolol
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Outcome_Other
effects
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Outcome_Physical
cardiovascular and respiratory functions
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Outcome_Physical
cardiovascular and respiratory functions
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Outcome_Physical
Intraocular pressure , blood pressure , heart rate , and respiratory functions , including percent forced expiratory volume in 1 second and peak expiratory flow rate
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Outcome_Physical
intraocular pressure and cardiovascular function
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Outcome_Physical
respiratory function
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Outcome_Physical
percent forced expiratory volume in 1 second , peak expiratory flow rate , and expiratory flow rate at 75 % vital capacity
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Outcome_Physical
cardiovascular and respiratory functions
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Outcome_Physical
bronchial sensitivity
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Participant_Age
young
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Participant_Sex
male
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Participant_Condition
Eight