82013
document
The influence of breast size on late radiation effects and association with radiotherapy dose inhomogeneity . A prospective assessment of late changes in breast appearance in 559 patients after tumour excision and radiotherapy for early breast cancer noted a strong association with breast size . Only 3/48 ( 6 % ) patients with small breasts developed moderate or severe late changes compared with 94/423 ( 22 % ) with medium sized breasts and 34/88 ( 39 % ) patients with large breasts ( p < 0.001 ) . One possibility is that greater radiation changes are related to greater dose inhomogeneity in women with large breasts . To explore this hypothesis , radiation dose distributions were assessed in a separate group of 37 women in whom three-level transverse computer tomographic images of the breast in the treatment position were available . A significant correlation was found between breast size and dose inhomogeneity which may account for the marked changes in breast appearance reported in women with large breasts .
82014
Intervention_Surgical
tumour excision
82015
Intervention_Physical
and radiotherapy
82016
Participant_Sample-size
559
82017
Participant_Condition
after tumour excision and radiotherapy
82018
Participant_Condition
early breast cancer