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document
Dexmedetomidine infusion for maintenance of anesthesia in patients undergoing abdominal hysterectomy . The usefulness of intravenous dexmedetomidine infusion for maintenance of anesthesia was studied in patients anesthetized with thiopental , fentanyl , nitrous oxide , and oxygen . Isoflurane was added as needed . The study was conducted in two parts , the first of which was an open dose-response study that comprised 14 women undergoing abdominal hysterectomy . After a suitable infusion regimen of dexmedetomidine was determined according to hemodynamic criteria , 20 patients were included in a double-blind , randomized placebo-controlled trial ( 10 receiving dexmedetomidine , 10 saline solution ) . Dexmedetomidine was administered as a two-step infusion to rapidly achieve a steady-state plasma concentration . The infusion was started with an initial dose given over 10 min before the induction of anesthesia ; at induction the maintenance rate was begun and continued until closure of the abdominal fascia . The infusion regimens of dexmedetomidine tested in the dose-response study ranged from 120 ng.kg-1 x min-1 , followed by 6 ng.kg-1 x min-1 , to 270 + 13.5 ng.kg-1 x min-1 . In the second part of the study , an initial infusion of 170 ng.kg-1 x min-1 was chosen , followed by 10 ng.kg-1 x min-1 for maintenance . Anesthesia was induced with thiopental ( 4.0 mg/kg ) and maintained with isoflurane in 70 % nitrous oxide and oxygen . Isoflurane was administered according to predetermined hemodynamic criteria . Dexmedetomidine infusion did not completely abolish the need for isoflurane but diminished its requirement by > 90 % ( P = 0.02 ) . The heart rate response to endotracheal intubation was significantly blunted .
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Intervention_Pharmacological
Dexmedetomidine
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Intervention_Pharmacological
dexmedetomidine
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Intervention_Pharmacological
dexmedetomidine
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
dexmedetomidine
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Intervention_Pharmacological
saline solution
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Intervention_Control
)
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Intervention_Pharmacological
Dexmedetomidine
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Intervention_Pharmacological
dexmedetomidine
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Intervention_Pharmacological
Dexmedetomidine
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Outcome_Other
Dexmedetomidine infusion did not completely abolish the need for isoflurane but diminished its requirement by > 90 % ( P = 0.02 )
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Outcome_Physical
heart rate response to endotracheal intubation
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Outcome_Other
was significantly blunted
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Participant_Condition
abdominal hysterectomy