77428
document
Haemodynamic profile of angiotensin II antagonism in essential hypertensive patients . 1 . The haemodynamic response to antagonistic ( 10 microgram min-1 kg-1 ) and agonistic ( 40 microgram min-1 kg-1 ) doses of saralasin was studied in young essential hypertensive patients . Blood pressure behaviour alone was thought to be inadequate to describe the response pattern . 2 . Pre-saralasin setting of the renin-angiotensin axis was varied with salt intake ( 15 and 290 mmol of Na+/day ) each for 10 days . This failed to influence blood pressure or plasma volume . 3 . Antagonist blockade after low salt lowered blood pressure in three patients with the highest plasma renin values . Cardiac output rose in two of these , but it dropped in all others . 4 . Decreases in cardiac output occurred with both doses of saralasin and even with suppression of the renin-angiotensin axis . This response is therefore unlikely to be due to removal of myocardial or venous angiotensin effects . 5 . The renin-angiotensin system played a part in maintenance of blood pressure only with severe salt restriction and in a small proportion of cases . 6 . No heart rate effect was seen with sarcalasin . 7 . Blood pressure and total peripheral resistance responses were dependent on pre- ( antagonist/agonist ) setting , but heart rate and cardiac output were not influenced by this factor .
77429
Intervention_Pharmacological
angiotensin II antagonism
77430
Intervention_Pharmacological
antagonistic
77431
Intervention_Pharmacological
agonistic
77432
Intervention_Pharmacological
saralasin
77433
Intervention_Pharmacological
renin-angiotensin axis
77434
Outcome_Physical
Blood pressure behaviour
77435
Outcome_Physical
blood pressure or plasma volume .
77436
Outcome_Physical
blood pressure
77437
Outcome_Physical
Cardiac output
77438
Outcome_Physical
cardiac output
77439
Outcome_Physical
myocardial or venous angiotensin effects .
77440
Outcome_Physical
blood pressure
77441
Outcome_Physical
heart rate effect
77442
Outcome_Physical
Blood pressure and total peripheral resistance responses
77443
Outcome_Physical
heart rate
77444
Outcome_Physical
cardiac output