78681
document
A comparative study of netilmicin-cefoxitin and gentamicin-cefoxitin in surgical patients with serious systemic infection . A double-blind , randomized study of gentamicin and netilmicin , each in combination with cefoxitin , was done to compare their respective efficacy and toxicity in patients with serious systemic infection . Thirty-seven surgical patients were evaluated for efficacy and 46 patients were evaluated for toxicity . The most frequently cultured organisms were Escherichia coli ( 15 ) , Klebsiella sp ( 9 ) , Proteus sp ( 6 ) , and Bacteroides sp ( 4 ) . For 23 patients treated with gentamicin-cefoxitin ( G-C ) , the clinical response was favorable in 20/21 ( 95.2 % ) evaluable cases , and elimination or marked reduction of 33/34 ( 97.1 % ) organisms was achieved . For 14 patients treated with netilmicin-cefoxitin ( N-C ) , the clinical response was favorable in 13/13 ( 100 % ) evaluable cases , and 19/20 ( 95 % ) organisms were eliminated or markedly reduced . Nephrotoxicity was defined as an increase in serum creatinine to greater than 25 % over baseline with an absolute rise of at least 0.5 mg/100 ml to a value greater than or equal to 1.3 mg/100 ml . Based on these criteria , nephrotoxicity was seen in 2/27 ( 7.4 % ) patients treated with G-C and in 3/19 ( 15.8 % ) patients treated with N-C. Ototoxicity was defined as a greater than 20 dB loss at any frequency . Based on these criteria , ototoxicity was seen in 5/27 ( 18.5 % ) patients treated with G-C and 2/19 ( 10.5 % ) patients treated with N-C . The data show no significant difference in toxicity and suggest that netilmicin and gentamicin are both highly effective in combination with cefoxitin in patients who have serious infections after surgery .
78682
Intervention_Pharmacological
netilmicin-cefoxitin
78683
Intervention_Pharmacological
gentamicin-cefoxitin
78684
Intervention_Pharmacological
gentamicin
78685
Intervention_Pharmacological
netilmicin
78686
Intervention_Pharmacological
cefoxitin
78687
Intervention_Pharmacological
gentamicin-cefoxitin
78688
Intervention_Pharmacological
netilmicin-cefoxitin
78689
Outcome_Other
efficacy and toxicity
78690
Outcome_Other
efficacy
78691
Outcome_Physical
clinical response
78692
Outcome_Other
clinical response
78693
Outcome_Physical
Nephrotoxicity
78694
Outcome_Physical
serum creatinine
78695
Outcome_Physical
nephrotoxicity
78696
Outcome_Physical
Ototoxicity
78697
Outcome_Physical
ototoxicity
78698
Outcome_Physical
toxicity
78699
Participant_Condition
serious systemic infection
78700
Participant_Condition
serious systemic infection .
78701
Participant_Sample-size
Thirty-seven
78702
Participant_Sample-size
46
78703
Participant_Condition
serious infections after surgery .