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document
Monotherapy of mild hypertension with nifedipine . The effectiveness of nifedipine as first-line monotherapy for mild diastolic hypertension ( range : 95 to 105 mm Hg ) was tested in this placebo-controlled , double-blind , randomized trial . Fifty-six patients were enrolled and , after titration of the placebo or active drug , they were followed for 12 weeks . Significant declines in the sitting systolic and diastolic pressures of -19 +/- 4 mm Hg ( standard error ) and -13 +/- 2 mm Hg , respectively , were observed during this follow-up period . Overall , 75 percent of patients receiving active drug had diastolic pressures less than or equal to 90 mm Hg at the last treatment visit . Heart rate was not significantly changed in the sitting position during the treatment period , and the majority of patients ( 75 percent ) showed a response to nifedipine doses of 10 or 20 mg orally three times daily in the capsule form . The levels of the systolic and diastolic pressures at entry were not predictive of the dose of nifedipine required for effective blood pressure control .
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Intervention_Pharmacological
nifedipine
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Intervention_Pharmacological
nifedipine
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
nifedipine
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Intervention_Pharmacological
nifedipine
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Outcome_Physical
hypertension
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Outcome_Other
effectiveness
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Outcome_Physical
diastolic hypertension
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Outcome_Physical
systolic and diastolic pressures
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Outcome_Physical
diastolic pressures
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Outcome_Physical
Heart rate
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Outcome_Physical
systolic
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Outcome_Physical
diastolic pressures
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Outcome_Other
effective blood pressure
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Participant_Condition
mild hypertension
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Participant_Condition
mild diastolic hypertension
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Participant_Sample-size
Fifty-six