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document
Prevention of premature labor by 17 alpha-hydroxyprogesterone caproate . Eighty pregnant women at high risk of giving birth prematurely were divided randomly into two groups . Treatment with either 17 alpha-hydroxyprogesterone caproate , 250 mg by intramuscular injection once a week , or a placebo was given in a double-blind fashion . Imminent premature labor occurred in 29.0 % of the treated group and in 59.4 % of the control group ( p less than 0.025 ) . The rate of premature deliveries was also significantly lower in the treated group ( 16.1 % ) than in the control group ( 37.82 % ) ( p less than 0.05 ) . There were no cases of perinatal death or fetal malformations in either group . The mean birth weight of all infants of the treated group was significantly higher than in those of the control group ( 3111.9 +/- 905 gm versus 2680 +/- 813.4 gm , p less than 0.05 ) . The results support treatment with progesterone caproate for the prevention of premature labor .
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Intervention_Pharmacological
17 alpha-hydroxyprogesterone caproate
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Intervention_Pharmacological
17 alpha-hydroxyprogesterone caproate
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Intervention_Control
placebo
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Intervention_Control
control
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Intervention_Pharmacological
progesterone caproate
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Outcome_Physical
rate of premature deliveries
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Outcome_Mortality
perinatal death
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Outcome_Adverse-effects
fetal malformations
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Outcome_Physical
mean birth weight
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Participant_Sample-size
Eighty
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Participant_Condition
pregnant women
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Participant_Condition
high risk of giving birth prematurely