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document
Doxymycine-cyanoacrylate treatment of recurrent aphthous ulcers . OBJECTIVE This study addressed the efficacy of singularly applied topical doxymycine in the pain relief treatment of recurrent aphthous stomatitis . STUDY DESIGN Thirty-one patients with recurrent aphthous lesions were examined and divided randomly in two groups . Experimental group ( n = 15 ) received a topical application of doxymycine and controls ( n = 16 ) received calcii gluconase in the same manner . Medications were covered by isobutyl cyanoacrylate ( Iso-Dent ) . Application was made only once during the recurrent aphthous ulcer episode . RESULTS Patients recorded their pain level on a visual analog scale for 10 days during healing . Pain decreased more rapidly in the experimental group , and a statistically significant difference ( p < 0.05 ) in the pain intensity was found from the second to the seventh day after application of doxymycine . CONCLUSIONS In recurrent aphthous ulcers , singular treatment of topical doxymycine-cyanoacrylate relieves the pain intensity remarkably for 6 days after a 1 day latency period . Topical doxymycine treatment further exerts potential to directly prevent tissue destruction and to indirectly suppress host inflammatory reaction .
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Intervention_Pharmacological
Doxymycine-cyanoacrylate
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Intervention_Pharmacological
doxymycine
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Intervention_Pharmacological
topical application of doxymycine
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Intervention_Control
controls
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Intervention_Pharmacological
isobutyl cyanoacrylate
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Intervention_Pharmacological
doxymycine
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Intervention_Pharmacological
doxymycine-cyanoacrylate
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Intervention_Pharmacological
doxymycine
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Outcome_Pain
pain relief
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Outcome_Pain
pain level
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Outcome_Pain
Pain
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Outcome_Pain
pain intensity
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Outcome_Pain
pain intensity
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Participant_Sample-size
Thirty-one
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Participant_Condition
aphthous lesions