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document
Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation : benefits of a moderate exercise intervention . UNLABELLED An allogeneic hematopoietic stem cell transplantation ( HSCT ) can have profound and lasting adverse effects on a patient 's physical and psychological well-being . So far , only few studies have investigated the effectiveness of physical activity over the entire inpatient phase of an allogeneic HSCT . PURPOSE We performed a randomized controlled study to examine the influence of a controlled moderate exercise program starting parallel to chemotherapeutic conditioning and total body irradiation on the patient 's physical and psychological constitution . PATIENTS AND METHODS Forty-seven patients undergoing an allogeneic HSCT were randomly assigned to an exercise group ( EG ) or a control group ( CG ) . While the EG took part in an endurance and activity of daily living-training twice a day , the CG received the clinic 's standard physiotherapy program once a day . RESULTS Significant differences and/or trends in favor of the EG were observed regarding the primary endpoint endurance performance ( P=0.002 ) , muscular strength ( P=0.022 ) , fatigue ( P=0.046 ) , and emotional state ( P=0.028 ) without posing an additional risk for the individual . CONCLUSION The results show that the training program is feasible and seems to have positive influences on physical performance and quality of life in patients undergoing an allogeneic HSCT . However , further studies are necessary to confirm these results .
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Intervention_Physical
moderate exercise intervention
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Intervention_Surgical
allogeneic hematopoietic stem cell transplantation
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Intervention_Physical
moderate exercise program
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Intervention_Physical
exercise group ( EG )
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Intervention_Physical
control group ( CG )
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Outcome_Other
effectiveness
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Outcome_Physical
endurance performance
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Outcome_Physical
muscular strength
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Outcome_Physical
fatigue
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Outcome_Physical
emotional state
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Outcome_Physical
physical performance and quality of life
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Participant_Condition
allogeneic hematopoietic stem cell transplantation
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Participant_Sample-size
Forty-seven
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Participant_Condition
allogeneic HSCT
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Participant_Condition
patients undergoing an allogeneic HSCT