68807
document
Absence of analgesic effect of intravenous melatonin administration during daytime after laparoscopic cholecystectomy : a randomized trial . STUDY OBJECTIVE To investigate whether melatonin administered intraoperatively reduced pain following laparoscopic cholecystectomy . DESIGN Randomized , placebo-controlled , double-blinded study . SETTING Two surgical departments in Copenhagen . PATIENTS 44 women between 18 and 70 years of age , who were surgical candidates for laparoscopic cholecystectomy . INTERVENTIONS Patients were anesthetized by a standard protocol and received a standard multimodal postoperative analgesic regimen . Patients undergoing surgery were admitted on the day of surgery and were discharged the day after surgery . Ten mg of intravenous ( IV ) melatonin or placebo were administered at the time of surgical incision . MEASUREMENTS Pain was assessed by a set of questionnaires documenting " pain at rest " using a visual analog scale ( VAS ) . The use of rescue medication was recorded . Sleep quality and general well-being were measured on separate VAS scales . Sleepiness was assessed by the Karolinska Sleepiness Scale . MAIN RESULTS Forty-four patients were included and randomized to the study . Three patients did not complete the study . No differences in VAS pain scores , sleep quality , general well-being , or sleepiness were found between the two groups in the postoperative period . The use of postoperative rescue medication did not differ between the groups . CONCLUSIONS The use of 10mg of IV melatonin administered during laparoscopic cholecystectomy did not affect postoperative pain or use of analgesic medication .
68808
Intervention_Pharmacological
melatonin
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Intervention_Pharmacological
melatonin
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Intervention_Pharmacological
anesthetized by a standard protocol and received a standard multimodal postoperative analgesic regimen
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Intervention_Pharmacological
intravenous ( IV ) melatonin
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Intervention_Control
placebo
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Intervention_Pharmacological
melatonin
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Outcome_Pain
pain
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Outcome_Pain
Pain
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Outcome_Physical
visual analog scale ( VAS )
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Outcome_Other
Sleep quality and general well-being
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Outcome_Physical
VAS scales . Sleepiness
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Outcome_Pain
VAS pain scores , sleep quality , general well-being , or sleepiness
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Outcome_Pain
postoperative pain or use of analgesic medication .
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Participant_Condition
laparoscopic cholecystectomy .
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Participant_Sample-size
44
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Participant_Sex
women
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Participant_Age
18 and 70 years of age
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Participant_Condition
laparoscopic cholecystectomy
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Participant_Condition
surgery
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Participant_Sample-size
Forty-four