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document
[ The value of local administration of antibiotics in treatment of bone infections ] . An open , controlled , randomized clinical investigation was carried out in 33 patients suffering from osteomyelitis . In the first group , 17 patients , a through drainage with sterile physiologic solution was applied , while in the second group , 16 patients , antibiotic was added to the sterile physiologic solution . In all patients values of C reactive protein ( CRP ) in the blood were examined , and later on every third day after the operation . A significant difference of average values of CRP between the 3rd and 21st day in both groups of patients was established , as well as the similarity in average values of CRP , which points to the fact that the mechanical effect of through drainage is dominant , speaking about rinsing focus of infection and eliminating necrotic tissues and small sequesters .
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Intervention_Pharmacological
antibiotics
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Intervention_Pharmacological
sterile physiologic solution
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Intervention_Pharmacological
antibiotic was added to the sterile physiologic solution
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Outcome_Other
A significant difference of
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Outcome_Physical
average values of CRP
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Outcome_Other
between the 3rd and 21st day in both groups of patients was established
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Outcome_Other
similarity in
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Outcome_Physical
average values of CRP
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Outcome_Physical
infection
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Participant_Condition
treatment of bone infections ]
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Participant_Condition
33 patients suffering from osteomyelitis .