89801
document
[ A randomized comparative study of surgical adjuvant chemotherapy using 5-fluorouracil and dl-leucovorin with CDDP 5-FU and dl-leucovorin for colorectal cancer ] . A randomized comparative study of surgical adjuvant chemotherapy using dl-leucovorin ( dl-LV ) and 5-fluorouracil ( 5-FU ) ( FL-therapy ) with CDDP , 5-FU , and dl-LV ( PFL-therapy ) was conducted . The following were the administration schedules : Arm A was 13 mg/m2 of CDDP , 300 mg/m2 of 5-FU , and 30 mg/body of dl-LV for 5 consecutive days and arm B was 300 mg/m2 of 5-FU and 30 mg/body of dl-LV for 5 consecutive days . Both regimens were followed by biweekly administration of the same dose of dl-LV and 5-FU in outpatients . Arm A was started at the 26th postoperative day and arm B at the 21st day on average . Some 26 cases composed of 11 cases of arm A and 15 cases of arm B completed the administration schedules . Only one case in arm A was complicated by local recurrence around 35 months after operation . Major toxicities were anorexia and neutropenia . Both toxicities were seen more in arm A than in arm B , showing complete recovery in all cases . These data suggest that PFL-therapy and FL-therapy seem to be possible and promising surgical adjuvant therapies for advanced colorectal carcinoma .
89802
Intervention_Surgical
surgical adjuvant chemotherapy
89803
Intervention_Pharmacological
5-fluorouracil and dl-leucovorin with CDDP 5-FU and dl-leucovorin
89804
Intervention_Surgical
surgical adjuvant chemotherapy
89805
Intervention_Pharmacological
dl-leucovorin ( dl-LV ) and 5-fluorouracil ( 5-FU ) ( FL-therapy ) with CDDP , 5-FU , and dl-LV ( PFL-therapy )
89806
Intervention_Pharmacological
CDDP
89807
Intervention_Pharmacological
5-FU
89808
Intervention_Pharmacological
dl-LV
89809
Intervention_Pharmacological
5-FU
89810
Intervention_Pharmacological
dl-LV
89811
Intervention_Pharmacological
dl-LV
89812
Intervention_Pharmacological
5-FU
89813
Outcome_Physical
local recurrence
89814
Outcome_Physical
toxicities
89815
Outcome_Physical
anorexia and neutropenia .
89816
Outcome_Physical
toxicities
89817
Outcome_Physical
advanced colorectal carcinoma .
89818
Participant_Condition
colorectal cancer
89819
Participant_Sample-size
26
89820
Participant_Sample-size
11
89821
Participant_Sample-size
15
89822
Participant_Condition
advanced colorectal carcinoma .