75597
document
Comparison of nicardipine and propranolol in the treatment of mild and moderate hypertension . In a double-blind controlled trial 22 patients with mild or moderate essential hypertension were treated with nicardipine 30 mg t.d.s . and 19 patients with propranolol 80 mg t.d.s . as monotherapy for 24 weeks . Blood pressure in both groups at the end of trial was equally and significantly reduced ; systolic pressure 22.2 mmHg and diastolic pressure 15.5 mmHg in the supine position , and 24.4 mmHg and 18.4 mmHg , respectively , in the standing position in those on nicardipine , and by 23.7 and 16.2 mmHg and 28.0 and 19.2 mmHg , respectively , in the propranolol group . There was an initial increase in heart rate in the nicardipine group , but the rise was only moderate ( 3 beats/min supine p = 0.3219 , and 7 beats/min standing , p = 0.0203 ) at the end of the 24 weeks . In the propranolol group heart rate was reduced markedly . Adverse effects occurred in 77 % of patients on nicardipine and in 63 % of those on propranolol , and there were no unexpected findings . The effects were mild in both groups and did not lead any patient to stop medication . One patient on propranolol was withdrawn from the trial because of poor blood pressure control and suspected angina pectoris after 5 weeks on active medication . There were no significant changes in blood chemistry , including lipoprotein classes . Overall , in comparison with propranolol , nicardipine was effective , well-tolerated and safe to use in the monotherapy of mild or moderate essential hypertension .
75598
Intervention_Pharmacological
nicardipine
75599
Intervention_Pharmacological
propranolol
75600
Intervention_Pharmacological
nicardipine
75601
Intervention_Pharmacological
propranolol
75602
Intervention_Pharmacological
nicardipine
75603
Intervention_Pharmacological
propranolol
75604
Intervention_Pharmacological
nicardipine
75605
Intervention_Pharmacological
propranolol
75606
Intervention_Pharmacological
nicardipine
75607
Intervention_Pharmacological
propranolol
75608
Intervention_Pharmacological
propranolol
75609
Intervention_Pharmacological
propranolol
75610
Outcome_Physical
Blood pressure
75611
Outcome_Physical
heart rate
75612
Outcome_Physical
heart rate
75613
Outcome_Adverse-effects
Adverse effects
75614
Outcome_Physical
blood pressure control
75615
Outcome_Physical
suspected angina pectoris
75616
Outcome_Physical
blood chemistry
75617
Outcome_Physical
lipoprotein classes
75618
Participant_Condition
hypertension
75619
Participant_Sample-size
22
75620
Participant_Condition
mild or moderate essential hypertension