88962
document
Treatment of men with flat ( FC ) or acuminata ( CA ) condylomata with interferon alpha-2a . This study was undertaken to assess the effect of CO2 laser vaporization , 5-fluorouracil 5 % ( 5-FU ) topical application and Interferon alpha-2a ( IFA alpha-2a ) in the treatment of C.A . or F.C . of the male genital tract . From March 1986 to September 1991 , 1372 men , sexual partners of women with F.C . or C.A . or cervical intraepithelial neoplasia , were submitted to peoscopy . One thousand and nineteen ( 74.27 % ) men presented with various penile lesions caused by HPV ( histologically confirmed ) ; of these 505 were treated for C.A . or F.C . or a combination of F.C . and C.A . The best treatment modalities , irrespective of the kind of lesion , were found to be the combination of 5-FU plus IFN alpha-2a ( high dose ) ( 98.27 % ) , the combination of CO2 laser vaporization plus 5-FU plus IFN alpha-2a ( high dose ) ( 93.93 % ) and the combination of CO2 laser vaporization plus 5-FU ( 87.23 % ) . In conclusion we believe that IFN alpha-2a can be used with excellent results as first line treatment in combination with CO2 laser vaporization or/plus 5-FU in patients with C.A . or F.C . or combined condylomata .
88963
Intervention_Pharmacological
interferon alpha-2a
88964
Intervention_Pharmacological
CO2 laser vaporization
88965
Intervention_Pharmacological
5-fluorouracil 5 % ( 5-FU ) topical application
88966
Intervention_Pharmacological
Interferon alpha-2a ( IFA alpha-2a )
88967
Intervention_Pharmacological
5-FU plus IFN alpha-2a
88968
Intervention_Pharmacological
CO2 laser vaporization plus 5-FU plus IFN alpha-2a
88969
Intervention_Pharmacological
combination of CO2 laser vaporization plus 5-FU
88970
Intervention_Pharmacological
IFN alpha-2a
88971
Intervention_Pharmacological
CO2 laser vaporization
88972
Intervention_Pharmacological
5-FU
88973
Participant_Condition
flat ( FC ) or acuminata ( CA ) condylomata
88974
Participant_Sample-size
1372
88975
Participant_Sample-size
One thousand and nineteen
88976
Participant_Sample-size
505
88977
Participant_Condition
combined condylomata