79527
document
General anaesthesia for caesarean section in severe pre-eclampsia . Comparison of the renal and hepatic effects of enflurane and halothane . In a randomized study of patients undergoing Caesarean section , either enflurane ( mean 0.24 MAC-h ) or halothane ( mean 0.23 MAC-h ) and 50 % nitrous oxide in oxygen were administered to women ( n = 12 ) with severe pre-eclampsia-eclampsia and to 16 healthy pregnant patients with normal renal and hepatic function . No evidence of nephrotoxicity was found in any pre-eclamptic or normal patient . Metabolism of enflurane resulted in plasma inorganic fluoride concentrations ( max 15 mumol litre -1 ) which were well below the toxic value . Postoperative liver function tests showed no important changes from preoperative values , although reductive metabolites of halothane were not measured . In patients with severe pre-eclampsia there appears no contraindication to enflurane or , probably , halothane as volatile supplements during general anaesthesia .
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Intervention_Pharmacological
General anaesthesia
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Intervention_Pharmacological
enflurane
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Intervention_Pharmacological
halothane
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Intervention_Pharmacological
enflurane
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Intervention_Pharmacological
halothane
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Intervention_Pharmacological
nitrous oxide in oxygen
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Intervention_Pharmacological
enflurane
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Intervention_Pharmacological
halothane
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Intervention_Pharmacological
enflurane
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Intervention_Pharmacological
halothane
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Intervention_Pharmacological
general anaesthesia
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Outcome_Adverse-effects
nephrotoxicity
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Outcome_Physical
plasma inorganic fluoride concentrations
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Outcome_Physical
liver function
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Outcome_Adverse-effects
contraindication to enflurane
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Participant_Condition
caesarean section in severe pre-eclampsia .
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Participant_Condition
patients undergoing Caesarean section , either enflurane ( mean 0.24 MAC-h ) or halothane ( mean 0.23 MAC-h ) and 50 % nitrous oxide in oxygen
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Participant_Condition
women ( n = 12 ) with severe pre-eclampsia-eclampsia and to 16 healthy pregnant patients with normal renal and hepatic function .