36558
document
Effects of fatty and lean fish intake on blood pressure in subjects with coronary heart disease using multiple medications . BACKGROUND Intake of fish and long-chain n-3 fatty acids has been of wide interest due to their beneficial effects on cardiovascular risk factors and lower coronary heart disease ( CHD ) risk . AIM OF THE STUDY The aim of this pilot study was to examine the effects of fatty fish and lean ( white ) fish on fatty acid composition of serum lipids and cardiovascular risk factors in subjects with CHD using multiple drugs for this condition . METHODS The study was an 8-week controlled , parallel intervention . Inclusion criteria were myocardial infarction or unstable ischemic attack , age under 70 years , use of betablockers and presence of sinus rhythm . The subjects were randomized to one of the following groups : 4 meals/week fatty fish ( n = 11 ) , 4 meals/week lean fish ( n = 12 ) and control diet including lean meat ( n = 10 ) . RESULTS The mean ( +/-SD ) of reported fish meals per week was 4.3 +/- 0.4 , 4.7 +/- 1.1 and 0.6 +/- 0.4 in the groups , respectively . The proportions of eicosapentaenoic and docosahexaenoic acids in serum lipids increased in the fatty fish group only ( P < 0.05 ) . Systolic and diastolic blood pressure levels decreased in the lean fish group ( 0 vs. 8 week : 3.5 +/- 3.2 and 4.6 +/- 3.6 % , respectively , P < 0.05 ) . Serum total triglyceride concentration did not significantly change . HDL cholesterol concentration change differed among groups but without significant post hoc differences . Apolipoprotein A-1 concentration decreased in the control group ( 0 vs. 8 week , P < 0.05 ) . Coagulation factors , 25-hydroxy vitamin D , and heart rate variability ( 24 h Holter ) did not change among the groups . CONCLUSIONS Our results suggest that intake of lean fish at least four times per week could reduce blood pressure levels in CHD patients .
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Intervention_Pharmacological
fatty and lean fish intake
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Intervention_Physical
fatty fish
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Intervention_Physical
lean ( white ) fish
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Intervention_Educational
4 meals/week
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Intervention_Physical
fatty fish
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Intervention_Educational
( n = 11 ) , 4 meals/week
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Intervention_Physical
lean fish
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Intervention_Educational
( n = 12 ) and
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Intervention_Control
control diet
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Intervention_Educational
including lean meat ( n = 10 ) .
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Intervention_Physical
lean fish
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Outcome_Physical
blood pressure
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Outcome_Physical
fatty acid composition of serum lipids
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Outcome_Physical
cardiovascular risk factors
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Outcome_Physical
proportions of eicosapentaenoic and docosahexaenoic acids in serum lipids
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Outcome_Physical
Systolic and diastolic blood pressure
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Outcome_Physical
Serum total triglyceride concentration
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Outcome_Physical
HDL cholesterol concentration
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Outcome_Physical
Apolipoprotein A-1 concentration
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Outcome_Physical
Coagulation factors , 25-hydroxy vitamin D , and heart rate variability ( 24 h Holter )
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Participant_Condition
subjects with coronary heart disease using multiple medications
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Participant_Condition
coronary heart disease ( CHD )
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Participant_Condition
subjects with CHD using multiple drugs for this condition
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Participant_Condition
Inclusion criteria were myocardial infarction
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Participant_Condition
unstable ischemic attack
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Participant_Age
age under 70 years
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Participant_Condition
use of betablockers and presence of sinus rhythm
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Participant_Condition
CHD patients