65620
document
Oral magnesium supplementation improves the metabolic profile of metabolically obese , normal-weight individuals : a randomized double-blind placebo-controlled trial . BACKGROUND AND AIMS We undertook this study to determine the efficacy of oral magnesium supplementation in the improvement of the metabolic profile and blood pressure in metabolically obese , normal-weight ( MONW ) individuals . METHODS A total of 47 MONW individuals with hypomagnesemia were enrolled in clinical a randomized double-blind placebo-controlled trial . Individuals in the intervention group received 30 mL of MgCl2 5 % solution ( equivalent to 382 mg of magnesium ) and individuals in the control group 30 mL of placebo solution , once daily during 4 months . In the absence of obesity or overweight , the presence of fasting glucose levels ≥100 mg/dL , HOMA-IR index ≥3 , triglyceride levels ≥150 mg/dL and/or systolic and diastolic blood pressure ≥140 and 90 mmHg defined the presence of the MONW phenotype . Hypomagnesemia was defined by serum magnesium concentration ≤1.8 mg/dL . RESULTS At basal conditions there were no significant differences between groups . At the end of follow-up , changes in the mean of systolic ( -2.1 vs. 3.9 % mmHg , p < 0.05 ) and diastolic ( -3.8 vs. 7.5 % mmHg , p < 0.05 ) blood pressures , HOMA-IR index ( -46.5 vs. -5.4 % , p < 0.0001 ) , fasting glucose ( -12.3 vs. -1.8 % mg/dL , p < 0.05 ) and triglyceride levels ( -47.4 % vs. 10.1 % mg/dL , p < 0.0001 ) were significantly lower in the subjects who received MgCl2 compared with individuals in the control group . CONCLUSIONS Oral magnesium supplementation improves the metabolic profile and blood pressure of MONW individuals .
65621
Intervention_Pharmacological
Oral magnesium supplementation
65622
Intervention_Pharmacological
magnesium
65623
Intervention_Pharmacological
MgCl2
65624
Intervention_Pharmacological
magnesium
65625
Intervention_Control
30 mL of placebo solution , once daily during 4 months
65626
Outcome_Other
efficacy
65627
Outcome_Other
metabolic profile
65628
Outcome_Other
blood pressure
65629
Outcome_Mental
fasting glucose levels
65630
Participant_Condition
metabolically obese , normal-weight individuals :