75276
document
Analgesic efficacy of piroxicam in the treatment of postoperative pain . Two randomized , double-blind , single-dose studies were conducted to assess the analgesic efficacy and safety of piroxicam for the treatment of moderate or severe postoperative pain . Study 1 evaluated the analgesic efficacy of piroxicam 20 mg compared with that of codeine sulfate 60 mg and placebo . A final patient population of 149 subjects rated pain intensity and pain relief at one half hour and one hour following treatment and then hourly for six hours , with a global assessment made at the completion of 24 hours . Piroxicam 20 mg was significantly more efficacious than placebo for all analgesic variables , including the sum of the pain intensity differences ( SPID ) , total pain relief ( TOTAL ) , percent SPID , duration of effect , and time to remedication . Codeine 60 mg was significantly superior to placebo for percent SPID and some hourly measures . Piroxicam 20 mg was significantly more effective than codeine 60 mg for percent SPID and a few hourly measures including time to remedication . Study 2 assessed the efficacy of piroxicam 20 mg or 40 mg compared with aspirin 648 mg and placebo . Sixty patients rated their pain intensity and relief hourly for 12 hours and at 24 hours after administration of study medication . Both doses of piroxicam were significantly more effective than placebo from Hours 2 to 12 for pain intensity difference ( PID ) and relief scores , as well as for SPID and TOTAL . Aspirin was significantly more effective than placebo from Hours 2 to 8 for relief and Hours 2 to 10 for PID as well as SPID and TOTAL . Piroxicam 40 mg was significantly more effective than aspirin 648 mg for SPID , TOTAL , and hourly measures beginning with Hour 6 through Hour 12 . Piroxicam 20 mg was significantly better than aspirin for a few hourly measures : Hours 7 to 9 for relief and Hour 7 for PID . In addition , effects of piroxicam 20 mg had a significantly longer duration than aspirin . Similarly , piroxicam 20 mg had a significantly longer time to remedication compared with aspirin and placebo . The results of these studies provide evidence in support of the longer duration of analgesic efficacy of piroxicam compared with codeine or aspirin in patients with postoperative pain .
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Intervention_Pharmacological
piroxicam
75278
Intervention_Pharmacological
piroxicam
75279
Intervention_Pharmacological
piroxicam
75280
Intervention_Pharmacological
codeine sulfate
75281
Intervention_Control
placebo
75282
Intervention_Pharmacological
Piroxicam
75283
Intervention_Control
placebo
75284
Intervention_Pharmacological
Codeine
75285
Intervention_Pharmacological
Piroxicam
75286
Intervention_Pharmacological
codeine
75287
Intervention_Pharmacological
piroxicam
75288
Intervention_Pharmacological
aspirin
75289
Intervention_Pharmacological
piroxicam
75290
Intervention_Pharmacological
Piroxicam
75291
Intervention_Pharmacological
aspirin
75292
Intervention_Pharmacological
Piroxicam
75293
Intervention_Pharmacological
aspirin
75294
Intervention_Pharmacological
piroxicam
75295
Intervention_Pharmacological
aspirin
75296
Intervention_Pharmacological
piroxicam
75297
Intervention_Pharmacological
codeine
75298
Intervention_Pharmacological
aspirin
75299
Outcome_Other
Analgesic efficacy
75300
Outcome_Pain
postoperative pain .
75301
Outcome_Other
analgesic efficacy and safety
75302
Outcome_Pain
moderate or severe postoperative pain .
75303
Outcome_Pain
pain intensity and pain relief
75304
Outcome_Other
efficacious
75305
Outcome_Pain
sum of the pain intensity differences ( SPID ) , total pain relief ( TOTAL )
75306
Outcome_Pain
percent SPID
75307
Outcome_Other
duration of effect
75308
Outcome_Other
time to remedication
75309
Outcome_Pain
percent SPID
75310
Outcome_Pain
percent SPID
75311
Outcome_Other
efficacy
75312
Outcome_Pain
pain intensity and relief
75313
Outcome_Other
effective
75314
Outcome_Pain
pain intensity difference ( PID ) and relief scores
75315
Outcome_Pain
SPID
75316
Outcome_Pain
TOTAL
75317
Outcome_Other
effective
75318
Outcome_Pain
relief
75319
Outcome_Pain
PID
75320
Outcome_Pain
SPID
75321
Outcome_Pain
TOTAL
75322
Outcome_Other
effective
75323
Outcome_Pain
SPID
75324
Outcome_Pain
TOTAL
75325
Outcome_Other
hourly measures
75326
Outcome_Pain
PID
75327
Outcome_Other
longer duration
75328
Outcome_Other
longer time to remedication
75329
Outcome_Other
duration of analgesic efficacy
75330
Outcome_Pain
postoperative pain