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document
Effects of a combination of evening primrose oil ( gamma linolenic acid ) and fish oil ( eicosapentaenoic + docahexaenoic acid ) versus magnesium , and versus placebo in preventing pre-eclampsia . In a placebo controlled , partially double-blinded , clinical trial , a combination of evening primrose oil and fish oil was compared to Magnesium Oxide , and to a Placebo in preventing Pre-Eclampsia of Pregnancy . All were given as nutritional supplements for six months to a group of primiparous and multiparous pregnant women . Some of these women had personal or family histories of hypertension ( 21 % ) . Only those patients who received prenatal care at the Central Maternity Hospital for Luanda were included in the study . Compared to the Placebo group ( 29 % ) , the group receiving the mixture of evening primrose oil and fish oil containing Gamma-linolenic acid ( GLA ) , Eicosapentaenoic acid ( EPA ) , and Docosahexaenoic acid ( DHA ) had a significantly lower incidence of edema ( 13 % , p = 0.004 ) . The group receiving Magnesium Oxide had statistically significant fewer subjects who developed hypertension of pregnancy . There were 3 cases of eclampsia , all in the Placebo group .
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Intervention_Pharmacological
gamma linolenic acid
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Intervention_Pharmacological
eicosapentaenoic + docahexaenoic acid
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Intervention_Pharmacological
magnesium
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
Magnesium Oxide
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Intervention_Control
Placebo
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Intervention_Control
Placebo
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Intervention_Pharmacological
evening primrose oil
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Intervention_Pharmacological
fish oil
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Intervention_Pharmacological
Gamma-linolenic acid ( GLA )
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Intervention_Pharmacological
Docosahexaenoic acid ( DHA )
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Intervention_Pharmacological
Magnesium Oxide
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Intervention_Control
Placebo
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Outcome_Physical
pre-eclampsia .
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Outcome_Physical
Pre-Eclampsia of Pregnancy .
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Outcome_Adverse-effects
incidence of
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Outcome_Physical
edema
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Outcome_Physical
hypertension of pregnancy .
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Outcome_Physical
eclampsia
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Participant_Condition
pre-eclampsia .
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Participant_Condition
Some of these women had personal or family histories of hypertension ( 21 % ) .