70953
document
Oxytocin reduces caloric intake in men . OBJECTIVE Preclinical studies indicate that oxytocin is anorexigenic and has beneficial metabolic effects . Oxytocin effects on nutrition and metabolism in humans are not well defined . It was hypothesized that oxytocin would reduce caloric intake and appetite and alter levels of appetite-regulating hormones . Metabolic effects of oxytocin were also explored . METHODS A randomized , placebo-controlled crossover study of single-dose intranasal oxytocin ( 24 IU ) in 25 fasting healthy men was performed . After oxytocin/placebo , subjects selected breakfast from a menu and were given double portions . Caloric content of food consumed was measured . Visual analog scales were used to assess appetite , and blood was drawn for appetite-regulating hormones , insulin , and glucose before and after oxytocin/placebo . Indirect calorimetry assessed resting energy expenditure ( REE ) and substrate utilization . RESULTS Oxytocin reduced caloric intake with a preferential effect on fat intake and increased levels of the anorexigenic hormone cholecystokinin without affecting appetite or other appetite-regulating hormones . There was no effect of oxytocin on REE . Oxytocin resulted in a shift from carbohydrate to fat utilization and improved insulin sensitivity . CONCLUSIONS Intranasal oxytocin reduces caloric intake and has beneficial metabolic effects in men without concerning side effects . The efficacy and safety of sustained oxytocin administration in the treatment of obesity warrants investigation .
70954
Intervention_Pharmacological
Oxytocin
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Intervention_Pharmacological
oxytocin
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Intervention_Pharmacological
Oxytocin
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Intervention_Pharmacological
oxytocin
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
single-dose intranasal oxytocin ( 24 IU )
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Intervention_Pharmacological
oxytocin/placebo
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Intervention_Physical
selected breakfast from a menu and were given double portions
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Intervention_Pharmacological
.
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Intervention_Physical
Caloric content of food consumed was measured
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Intervention_Physical
blood was drawn for appetite-regulating hormones
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Intervention_Physical
insulin
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Intervention_Physical
glucose before and after oxytocin/placebo
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Intervention_Pharmacological
Oxytocin
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Intervention_Pharmacological
Oxytocin
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Intervention_Pharmacological
oxytocin
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Intervention_Pharmacological
oxytocin
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Participant_Sex
men .
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Participant_Sample-size
25
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Participant_Condition
fasting healthy
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Participant_Sex
men
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Participant_Sex
men