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document
Ceftriaxone versus ampicillin and chloramphenicol for treatment of bacterial meningitis in children . 78 patients with bacterial meningitis were evaluated in a prospective , randomised study comparing twice-daily ceftriaxone as single-drug therapy with ampicillin and chloramphenicol given every 6 h. The groups were comparable in age , sex , days of illness before admission , and bacterial colony counts in cerebrospinal fluid ( CSF ) . The pathogens were Haemophilus influenzae type b ( 54 cases ) , streptococci ( 9 cases ) , meningococci ( 9 cases ) , and unknown ( 6 cases ) . In 40 CSF specimens obtained 4-12 h after initiation of therapy , cultures were negative in 57 % of the ceftriaxone patients and in 42 % of the others . The mean falls in the CSF bacterial colony counts were 4.7 and 5.0 log10 colony-forming units/ml , respectively . Mean bactericidal activity in CSF was significantly greater in the ceftriaxone than in the conventional treatment group at the beginning and end of therapy . There were no significant differences in clinical responses or in frequency of complications , except for mild diarrhoea , which occurred in 16 ceftriaxone patients and in 8 in the other group ( p less than 0.05 ) .
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Intervention_Pharmacological
Ceftriaxone
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Intervention_Pharmacological
ampicillin and chloramphenicol
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Intervention_Pharmacological
ceftriaxone
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Intervention_Pharmacological
ampicillin and chloramphenicol
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Intervention_Pharmacological
ceftriaxone
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Intervention_Pharmacological
ceftriaxone
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Outcome_Physical
bacterial meningitis
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Outcome_Other
cultures were negative
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Outcome_Other
mean falls in the CSF bacterial colony counts
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Outcome_Physical
Mean bactericidal activity in CSF
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Outcome_Other
clinical responses
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Outcome_Adverse-effects
frequency of complications
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Outcome_Physical
mild diarrhoea
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Participant_Condition
bacterial meningitis in children . 78 patients with bacterial meningitis were evaluated