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document
The comparative safety and diagnostic accuracy of adenosine myocardial perfusion imaging in women versus men . STUDY OBJECTIVE To determine if the diagnostic accuracy and safety of intravenous adenosine myocardial perfusion imaging is significantly different in men compared with women . DESIGN Prospective , comparative , open-label clinical trial . SETTING Nuclear medicine laboratory in a university-affiliated hospital . PATIENTS Consecutive patients who were referred for evaluation of known or suspected coronary artery disease . Patients were judged not to be able to exercise adequately . INTERVENTIONS Coronary angiography was conducted within 6 weeks of an adenosine thallium-201 myocardial perfusion imaging study . MEASUREMENTS AND MAIN RESULTS Diagnostic accuracy is shown in the table . [ table : see text ] Overall , side effects from adenosine were not different between men and women . The frequencies of ST depression and chest pain were significantly greater in women than men , although their etiologies are unknown . The frequency of severe side effects such as heart block and hypotension was not different between men and women . CONCLUSIONS The diagnostic accuracy and safety of adenosine thallium-201 myocardial perfusion imaging are generally similar in women and men .
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Intervention_Physical
adenosine myocardial perfusion imaging
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Intervention_Physical
adenosine myocardial perfusion imaging
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Intervention_Physical
Coronary angiography was conducted within 6 weeks of an adenosine thallium-201 myocardial perfusion imaging study
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Intervention_Physical
adenosine thallium-201 myocardial perfusion imaging
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Outcome_Other
safety
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Outcome_Other
diagnostic accuracy
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Outcome_Other
Diagnostic accuracy
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Outcome_Adverse-effects
side effects
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Outcome_Physical
ST depression
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Outcome_Physical
chest pain
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Outcome_Adverse-effects
severe side effects
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Outcome_Adverse-effects
heart block and hypotension
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Participant_Condition
women versus men .