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document
Effect of finasteride treatment on suburethral prostatic microvessel density in patients with hematuria related to benign prostate hyperplasia . INTRODUCTION In the present study we evaluated the effect of short-term finasteride treatment on microvessel density ( MVD ) which is an indicator of prostatic angiogenesis in patients with hematuria secondary to benign prostatic hyperplasia ( BPH ) . MATERIALS AND METHODS 30 patients who were candidates for BPH surgery were prospectively included in the study . All patients had history of gross hematuria and evaluated by ultrasonography and cystoscopy . The patients were randomized two groups before surgery . The treatment group consisted of 13 patients who were given 5 mg finasteride daily for 4 weeks before surgery . The control group consisted of 17 patients who did not receive finasteride before surgery . During surgery , resected suburethral and hyperplastic prostate specimens were sent for histopathologic MVD determination separately . RESULTS Mean MVD in the suburethral portion of prostate was significantly lower in patients treated with finasteride when compared with controls ( 9.08 +/- 5.6 and 13.94 +/- 5.90 , respectively , p < 0.05 ) . Mean MVD for the hyperplastic portion of prostate was similar for the finasteride and control groups ( 14.21 +/- 7.10 and 19.75 +/- 9.73 , respectively , p > 0.05 ) . CONCLUSION The potential role of finasteride on hematuria related to BPH may be the suppressive effect on MVD in the suburethral tissue of prostate .
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Intervention_Pharmacological
finasteride
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Intervention_Pharmacological
finasteride
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Intervention_Pharmacological
5 mg finasteride daily
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Intervention_Pharmacological
did not receive finasteride
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Outcome_Physical
Mean MVD in the suburethral portion of prostate was significantly lower
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Outcome_Physical
Mean MVD for the hyperplastic portion of prostate
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Outcome_Physical
MVD
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Participant_Condition
patients with hematuria related to benign prostate hyperplasia
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Participant_Condition
patients with hematuria secondary to benign prostatic hyperplasia ( BPH )
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Participant_Sample-size
30 patients
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Participant_Condition
candidates for BPH surgery
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Participant_Condition
history of gross hematuria and evaluated by ultrasonography and cystoscopy