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document
Comparison of the antiemetic effect of ramosetron and combined ramosetron and midazolam in children : a double-blind , randomised clinical trial . CONTEXT Postoperative nausea and vomiting remains a clinically important problem after strabismus surgery in children . OBJECTIVE To study the benefit of adding midazolam to ramosetron on the incidence of postoperative nausea , retching or vomiting and on the incidence of postoperative agitation . DESIGN A randomised , double-blind comparison . SETTING The operating theatre suite and day care unit of Seoul National University Hospital . The study period was January to December 2010 . PATIENTS In total , 405 paediatric patients ( aged 4-12 years ) undergoing strabismus surgery were enrolled and randomly assigned to one of two groups , ramosetron or ramosetron with midazolam . INTERVENTION Patients received either ramosetron 6 μg kg or ramosetron 6 μg kg and midazolam 0.1 mg kg prior to induction of anaesthesia . MAIN OUTCOME MEASURES The incidences of nausea , retching or vomiting in the first 48 h after surgery , and the incidence of emergence agitation in the post-anaesthetic care unit . RESULT The incidences of nausea , retching or vomiting during the first and second 24-h periods after surgery were similar in the two groups . There was a small , clinically insignificant reduction in delirium scores in the ramosetron with midazolam group . CONCLUSION Adding midazolam to ramosetron had no advantages over ramosetron alone in reducing the incidence of postoperative nausea and vomiting in children undergoing strabismus surgery .
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Intervention_Pharmacological
ramosetron
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Intervention_Pharmacological
combined ramosetron and midazolam
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Intervention_Pharmacological
midazolam to ramosetron
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Intervention_Surgical
strabismus surgery
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Intervention_Pharmacological
ramosetron or ramosetron with midazolam
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Participant_Condition
children :
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Participant_Condition
strabismus surgery in children .