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document
Improved adherence with once-daily versus twice-daily dosing of mometasone furoate administered via a dry powder inhaler : a randomized open-label study . BACKGROUND Poor adherence with prescribed asthma medication is a major barrier to positive treatment outcomes . This study was designed to determine the effect of a once-daily administration of mometasone furoate administered via a dry powder inhaler ( MF-DPI ) on treatment adherence compared with a twice-daily administration . METHODS This was a 12-week open-label study designed to mimic an actual clinical setting in patients > or=12 years old with mild-to-moderate persistent asthma . Patients were randomized to receive MF-DPI 400 microg once-daily in the evening or MF-DPI 200 microg twice-daily . Adherence was assessed primarily using the number of actual administered doses reported from the device counter divided by the number of scheduled doses . Self-reports were also used to determine adherence . Health-related quality of life , healthcare resource utilization , and days missed from work or school were also reported . RESULTS 1233 patients were randomized . The mean adherence rates , as measured by the automatic dose counter , were significantly better ( P < 0.001 ) with MF-DPI 400 microg once-daily in the evening ( 93.3 % ) than with MF-DPI 200 microg twice-daily ( 89.5 % ) . Mean adherence rates based on self-reports were also significantly better ( P < 0.001 ) with MF-DPI 400 microg QD PM ( 97.2 % ) than with MF-DPI 200 microg twice-daily ( 95.3 % ) . Adherence rates were lower in adolescents ( 12-17 years old ) . Health-related quality of life improved by 20 % in patients using MF-DPI once-daily in the evening and by 14 % in patients using MF-DPI twice-daily . Very few ( < 8 % ) patients missed work/school . CONCLUSION Mean adherence rates were greater with a once-daily dosing regimen of MF-DPI than with a twice-daily dosing regimen.This trial was completed prior to the ISMJE requirements for trial registration .
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Intervention_Pharmacological
mometasone furoate
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Intervention_Pharmacological
mometasone furoate
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Intervention_Pharmacological
MF-DPI 400 microg once-daily in the evening
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Intervention_Pharmacological
MF-DPI 200 microg twice-daily
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Intervention_Pharmacological
MF-DPI
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Outcome_Mental
adherence
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Outcome_Mental
Adherence
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Outcome_Mental
actual administered doses
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Outcome_Mental
Health-related quality of life
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Outcome_Other
healthcare resource utilization
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Outcome_Mental
days missed from work or school
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Outcome_Other
mean
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Outcome_Mental
adherence rates
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Outcome_Other
Mean
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Outcome_Mental
adherence rates
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Outcome_Mental
Adherence rates
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Outcome_Mental
Health-related quality of life
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Outcome_Mental
missed work/school
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Outcome_Mental
adherence rates
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Participant_Age
> or=12 years old
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Participant_Condition
mild-to-moderate persistent asthma
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Participant_Sample-size
1233