17994
document
Gabapentin for the prevention of postoperative pain after vaginal hysterectomy . Gabapentin alleviates and/or prevents acute nociceptive and inflammatory pain both in animals and volunteers , especially when given before trauma . Gabapentin might also reduce postoperative pain . To test the hypothesis that gabapentin reduces the postoperative need for additional pain treatment ( postoperative opioid sparing effect of gabapentin in humans ) , we gave 1200 mg of gabapentin or 15 mg of oxazepam ( active placebo ) 2.5 h prior to induction of anaesthesia to patients undergoing elective vaginal hysterectomy in an active placebo-controlled , double blind , randomised study . Gabapentin reduced the need for additional postoperative pain treatment ( PCA boluses of 50 microg of fentanyl ) by 40 % during the first 20 postoperative hours . During the first 2 postoperative hours pain scores at rest and worst pain score ( VAS 0-100 mm ) were significantly higher in the active placebo group compared to the gabapentin-treated patients . Additionally , pretreatment with gabapentin reduced the degree of postoperative nausea and incidence of vomiting/retching possibly either due to the diminished need for postoperative pain treatment with opioids or because of an anti-emetic effect of gabapentin itself . No preoperative differences between the two groups were encountered with respect to the side effects of the premedication . However , 15 mg oxazepam was more effective in relieving preoperative anxiety than 1200 mg gabapentin .
17995
Intervention_Pharmacological
Gabapentin
17996
Intervention_Pharmacological
Gabapentin
17997
Intervention_Pharmacological
Gabapentin
17998
Intervention_Pharmacological
gabapentin
17999
Intervention_Pharmacological
gabapentin
18000
Intervention_Pharmacological
gabapentin
18001
Intervention_Pharmacological
oxazepam (
18002
Intervention_Control
active placebo
18003
Intervention_Pharmacological
)
18004
Intervention_Surgical
elective vaginal hysterectomy
18005
Intervention_Pharmacological
Gabapentin
18006
Intervention_Control
placebo
18007
Intervention_Pharmacological
gabapentin-treated
18008
Intervention_Pharmacological
gabapentin
18009
Intervention_Pharmacological
gabapentin
18010
Intervention_Pharmacological
oxazepam
18011
Intervention_Pharmacological
gabapentin
18012
Outcome_Pain
postoperative pain
18013
Outcome_Pain
acute nociceptive and inflammatory pain
18014
Outcome_Pain
postoperative pain
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Outcome_Physical
postoperative need for additional pain treatment
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Outcome_Pain
postoperative pain treatment
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Outcome_Pain
pain scores at rest
18018
Outcome_Pain
worst pain score
18019
Outcome_Physical
degree of postoperative
18020
Outcome_Adverse-effects
nausea and incidence of vomiting/retching
18021
Outcome_Pain
postoperative pain
18022
Outcome_Other
effective
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Outcome_Physical
preoperative anxiety
18024
Participant_Condition
postoperative pain
18025
Participant_Condition
vaginal hysterectomy