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document
Tetrahydrobiopterin in the treatment of children with autistic disorder : a double-blind placebo-controlled crossover study . Twelve children , all boys , aged 4 to 7 years , with a diagnosis of autistic disorder and low concentrations of spinal 6R-l-erythro-5,6,7,8-tetrahydrobiopterin ( tetrahydrobiopterin ) were selected to participate in a double-blind , randomized , placebo-controlled , crossover study . The children received a daily dose of 3 mg tetrahydrobiopterin per kilogram during 6 months alternating with placebo . Treatment-induced effects were assessed with the Childhood Autism Rating Scale every third month . The results showed small nonsignificant changes in the total scores of Childhood Autism Rating Scale after 3- and 6-month treatment . Post hoc analysis looking at the 3 core symptoms of autism , that is , social interaction , communication , and stereotyped behaviors , revealed a significant improvement of the social interaction score after 6 months of active treatment . In addition , a high positive correlation was found between response of the social interaction score and IQ . The results indicate a possible effect of tetrahydrobiopterin treatment .
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Intervention_Pharmacological
Tetrahydrobiopterin
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Intervention_Control
placebo-controlled
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
tetrahydrobiopterin
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Intervention_Control
placebo
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Intervention_Pharmacological
tetrahydrobiopterin
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Outcome_Physical
Treatment-induced effects
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Outcome_Mental
Childhood Autism Rating Scale
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Outcome_Mental
total scores of Childhood Autism Rating Scale
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Outcome_Mental
social interaction , communication , and stereotyped behaviors
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Outcome_Mental
social interaction score
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Outcome_Mental
response of the social interaction score and IQ .