90807
document
Maximal bioavailability of digoxin from tablets and oral solution in steady state . Comparison has been made between the absorption of digoxin from Lanoxin tablets and the absorption of international chemical reference substance digoxin from an oral solution . Plasma levels , areas under 24-hour plasma concentration curves and urinary excretion were similar by both formulations in steady state . 78 % of the digoxin administered was absorbed from the tablets and 76 % from the solution . Rapid dissolution in the intestinal fluids accounts for the high digoxin bioavailability of the tablets .
90808
Intervention_Pharmacological
digoxin
90809
Intervention_Pharmacological
digoxin
90810
Intervention_Pharmacological
Lanoxin
90811
Intervention_Pharmacological
digoxin from an oral solution .
90812
Intervention_Pharmacological
digoxin
90813
Intervention_Pharmacological
digoxin
90814
Outcome_Other
Maximal bioavailability
90815
Outcome_Physical
absorption of digoxin
90816
Outcome_Physical
digoxin
90817
Outcome_Physical
Plasma levels , areas under 24-hour plasma concentration curves and urinary excretion
90818
Outcome_Other
digoxin
90819
Outcome_Other
digoxin bioavailability
90820
Participant_Condition
Maximal bioavailability of digoxin from tablets and oral solution in steady state .