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document
Effect of Orlistat in obese patients with heart failure : a pilot study . Heart failure is the leading cause of hospitalization . Obesity is increasingly common and is a major public health problem . The aim of this study is to assess whether obese patients with heart failure can benefit from losing weight via an orlistat-assisted diet . This randomized clinical trial included obese patients with ejection fractions < or =40 % . Orlistat and diet counseling were compared with diet counseling alone . Twenty-one consecutive obese patients with heart failure were recruited . Significant improvement in 6-minute walk test ( 45.8 m ; 95 % confidence interval , 5.2-86.4 m ; p=0.031 ) , functional class ( -0.6+/-0.5 , p=0.014 ) , weight loss ( -8.55 kg ; 95 % confidence interval , -13.0 to -4.1 kg ; p < 0.001 ) and also significant decreases in total cholesterol ( p=0.017 ) , low-density lipoprotein cholesterol ( p=0.03 ) , and triglycerides ( p=0.036 ) were observed in the orlistat group . Orlistat can promote significant weight loss and symptoms of relief in obese patients with heart failure , as measured by 6-minute walk test and functional capacity . The lipid profile improved . Orlistat was safe and well tolerated .
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Intervention_Pharmacological
Orlistat
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Intervention_Pharmacological
orlistat-assisted diet
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Intervention_Control
Orlistat and diet counseling were compared with diet counseling alone
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Intervention_Pharmacological
Orlistat
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Intervention_Pharmacological
Orlistat
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Outcome_Other
6-minute walk test
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Outcome_Physical
functional class
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Outcome_Physical
weight loss
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Outcome_Physical
total cholesterol
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Outcome_Physical
low-density lipoprotein cholesterol
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Outcome_Physical
triglycerides
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Outcome_Physical
weight loss
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Outcome_Physical
symptoms of relief
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Participant_Condition
obese
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Participant_Condition
heart failure
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Participant_Condition
obese
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Participant_Condition
heart failure
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Participant_Condition
obese
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Participant_Sample-size
Twenty-one
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Participant_Condition
obese
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Participant_Condition
heart failure