73647
document
A comparison of high and low fat meals on postprandial esophageal acid exposure . Fatty foods have been identified as precipitating factors in symptomatic gastroesophageal reflux ( GER ) . A fat meal has also been found to decrease lower esophageal sphincter pressure ( LESP ) in normal subjects . We used the ambulatory 24-h pH monitor to assess esophageal acid exposure in 10 normal subjects and 10 GER patients following low and high fat meals eaten in two body positions . The meals had nearly identical protein content , volumes , and calories . On successive days , patients ingested one of the meals twice , followed by random assignment to 3 h upright and 3 h recumbent position . Acid exposure for each hour over a 3-h postprandial ( PP ) period was assessed as the percent time pH less than 4.0 . Increased upright acid exposure occurred in normals after the high fat ( 6.2 +/- 2.1 % ; mean +/- SE ) compared with the low fat meal ( 1.5 +/- 0.5 % ; p less than 0.05 ) . GER patients had greater ( p less than 0.05 ) acid exposure than normals in all study periods , but no differences were found between low and high fat meals in either study position . High fat meals induce upright GER in normals , but do not significantly affect the abnormal amount of GER in patients . In addition , progressive increases in acid exposure were found over the 3 postprandial hours in GER patients in a recumbent position . The findings are consistent with prior data showing decreased LESP with a fat meal in normals .
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Intervention_Other
high and low fat meals
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Intervention_Pharmacological
low and high fat meals
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Intervention_Pharmacological
two body positions
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Intervention_Pharmacological
meals
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Intervention_Other
upright and
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Intervention_Physical
recumbent position
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Outcome_Physical
esophageal sphincter pressure ( LESP )
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Outcome_Physical
Acid exposure for each hour
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Outcome_Physical
upright acid exposure
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Outcome_Physical
acid exposure
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Outcome_Physical
upright GER
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Outcome_Physical
acid exposure
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Outcome_Physical
LESP
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Participant_Condition
postprandial esophageal
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Participant_Condition
gastroesophageal reflux
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Participant_Condition
GER
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Participant_Sample-size
10
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Participant_Sample-size
10