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document
[ Diphtheria antitoxin level 2 years after booster vaccination ] . In a prospective , controlled , randomized , multicenter study the immunogenicity of a single ( day 0 ) and two ( day 0 , 28 ) booster vaccination against diphtheria were compared in subjects who had received their last diphtheria vaccination more than 10 years ago . Both short-term and long-term immunogenicity was assessed by determining diphtheria antitoxin levels four weeks after vaccination and after one and two years . 102 subjects received the first booster vaccination , and 83 were vaccinated twice . Prior to the first vaccination 27 % of the subjects had a diphtheria antitoxin level below 0.01 I.U./ml ; after the first booster only 5 % were unprotected . The second booster did not show a significant effect , however , in 1 of the 5 subjects who were still unprotected after the first booster the second elicited an antitoxin level of more than 0.01 I.U./ml . After one and two years 7 % and 8 % of the subjects had diphtheria antitoxin level below 0.01 I.U./ml . A serological effect of a second booster vaccination four weeks after the first one could not be demonstrated neither after one nor after two years .
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Intervention_Pharmacological
booster vaccination
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Intervention_Pharmacological
booster vaccination against diphtheria
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Intervention_Pharmacological
diphtheria vaccination
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Intervention_Pharmacological
diphtheria antitoxin
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Intervention_Pharmacological
first booster vaccination
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Intervention_Physical
vaccinated
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Intervention_Pharmacological
twice
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Intervention_Pharmacological
booster
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Intervention_Pharmacological
booster vaccination
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Outcome_Physical
diphtheria antitoxin levels
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Outcome_Physical
diphtheria antitoxin level
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Outcome_Physical
antitoxin level
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Outcome_Physical
diphtheria antitoxin level
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Participant_Condition
subjects who had received their last diphtheria vaccination more than 10 years ago .