86043
document
[ Prevention of pneumonia by endotracheal micronebulization of tobramycin ] . In 69 artificially ventilated patients the clinical , bacteriological and pharmacological effects of endotracheally administered tobramycin were studied in comparison to a control group . In the therapy group , 52 % of all specimens were sterile , in the control group only 25 % . During the first 4 days these changes were significant ( p < 0.05 ) . In the therapy group the endotracheal colonisation with ps . aeruginosa was significantly lower between the 4th and 14th day ( p < 0.05 ) . The incidence of secondary pneumonia was reduced from 42 % to 17.5 % ( not significant ) . Systemic administration of antibiotics , e.g . of aminoglycosides , was significantly more often necessary in the control group . No increasing of growth of fungi in the upper respiratory tract was observed , but these was a non-significantly higher incidence mainly of staph . epidermidis . The application of 80 mg tobramycin four times a day as an aerosol was well tolerated by the patients . Under there conditions , tobramycin could not be measured in the serum . No allergic reactions , increased respiratory pressures or bronchoconstrictions were observed .
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Intervention_Pharmacological
tobramycin
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Intervention_Pharmacological
tobramycin
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Outcome_Physical
pneumonia
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Outcome_Physical
clinical , bacteriological
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Outcome_Physical
pharmacological effects
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Outcome_Physical
endotracheal colonisation with ps . aeruginosa
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Outcome_Physical
incidence of secondary pneumonia
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Outcome_Physical
Systemic administration of antibiotics
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Outcome_Physical
growth of fungi in the upper respiratory tract
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Outcome_Physical
incidence mainly of staph . epidermidis
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Outcome_Other
tolerated
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Outcome_Adverse-effects
allergic reactions
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Outcome_Adverse-effects
respiratory pressures
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Outcome_Adverse-effects
bronchoconstrictions
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Participant_Condition
pneumonia
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Participant_Condition
69 artificially ventilated