89494
document
Effect of desonide ointment , 0.05 % , on the hypothalamic-pituitary-adrenal axis of children with atopic dermatitis . Desonide ointment has demonstrated a good safety and efficacy profile during the many years it has been used in treating dermatoses . However , there have been no controlled clinical trials to evaluate its systemic safety when used in treating children . Suppression of the hypothalamic-pituitary-adrenal ( HPA ) axis can occur after repeated application of topical corticosteroids . In general , the degree of suppression of the HPA axis function is related to the daily dosage of steroid given , the duration of its administration , the extent of body surface covered , and the potency of the corticosteroid . This study sought to determine the comparative effects of 0.05 percent desonide and 2.5 percent hydrocortisone ointments on the HPA axis of children with atopic dermatitis . There was no suppression of early morning cortisol in either treatment group . The ACTH-stimulated mean cortisol values after four weeks of treatment were not significantly different from the baseline values for either treatment group . We conclude that neither 0.05 percent desonide ointment nor 2.5 percent hydrocortisone ointment compromised the HPA axis of children with atopic dermatitis treated topically for four weeks .
89495
Intervention_Pharmacological
desonide ointment , 0.05 %
89496
Intervention_Pharmacological
Desonide ointment
89497
Intervention_Pharmacological
desonide
89498
Intervention_Pharmacological
hydrocortisone ointments
89499
Intervention_Pharmacological
0.05 percent desonide ointment
89500
Intervention_Pharmacological
2.5 percent hydrocortisone ointment
89501
Outcome_Physical
degree of suppression of the HPA axis function
89502
Outcome_Physical
suppression of early morning cortisol
89503
Outcome_Physical
ACTH-stimulated mean cortisol values
89504
Participant_Age
children
89505
Participant_Condition
atopic dermatitis
89506
Participant_Age
children
89507
Participant_Age
children
89508
Participant_Condition
atopic dermatitis
89509
Participant_Age
children
89510
Participant_Condition
atopic dermatitis