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document
Increased growth hormone response to sumatriptan challenge in adult autistic disorders . Serotonergic ( 5-HT ) abnormalities have been documented in autism . To assess sensitivity of the 5-HT1d receptor , growth hormone response to the 5-HT1d receptor agonist sumatriptan was studied in adult autistic patients and matched normal controls . In this study , 11 adult patients with autism or Asperger 's disorder were compared with nine matched controls . All subjects were randomized to single dose sumatriptan ( 6 mg SQ ) and placebo challenges , separated by a 1-week interval , and growth hormone was measured before and during the challenges . The results showed a highly significant diagnosisxdrugxtime interaction on repeated measure analysis covaried for baseline . This suggests that autistic patients had significantly greater growth hormone response to sumatriptan than normal controls , independent of placebo effects . Therefore , abnormalities in 5-HT regulation in autism may be related to increased sensitivity of the 5-HT1d inhibitory receptor in autism .
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Intervention_Pharmacological
sumatriptan
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Intervention_Pharmacological
5-HT1d receptor agonist sumatriptan
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Intervention_Pharmacological
single dose sumatriptan ( 6 mg SQ )
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Intervention_Control
placebo challenges
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Intervention_Pharmacological
growth hormone was measured before and during the challenges
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Intervention_Pharmacological
sumatriptan
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Outcome_Physical
Increased growth hormone
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Outcome_Physical
growth hormone response
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Outcome_Physical
growth hormone
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Outcome_Physical
diagnosisxdrugxtime interaction
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Outcome_Physical
growth hormone response
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Participant_Age
adult
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Participant_Condition
autistic disorders