45163
document
Metformin , naltrexone , or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome . To compare the short-term effects of metformin ( M ) , naltrexone ( N ) , and a combination of OC and prednisolone ( OC/Pr ) on the metabolic state and the ovarian function of PCOS women , we randomized 29 women to a 3-month course of therapy . We observed significant improvements in hyperandrogenemia and ovulation rates in PCOS women of all three groups , in the absence of changes in the metabolic state , suggesting that insulin resistance in PCOS patients is only one of several factors leading to hyperandrogenemic ovarian failure .
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Intervention_Pharmacological
Metformin , naltrexone , or the combination of prednisolone and antiandrogenic oral contraceptives
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Intervention_Pharmacological
metformin ( M ) , naltrexone ( N ) , and a combination of OC and prednisolone ( OC/Pr )
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Outcome_Physical
metabolic state
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Outcome_Physical
ovarian function
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Outcome_Physical
hyperandrogenemia and ovulation rates
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Outcome_Physical
metabolic state
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Participant_Sex
women
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Participant_Condition
polycystic ovary syndrome
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Participant_Condition
PCOS
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Participant_Sample-size
29
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Participant_Sex
women
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Participant_Sex
women
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Participant_Condition
PCOS