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document
Local contextual processing in major depressive disorder . OBJECTIVE The study investigated local contextual processing in patients with major depressive disorder ( MDD ) . This was defined as the ability to utilize predictive contextual information to facilitate detection of predictable versus random targets . METHOD We recorded EEG in 15 MDD patients and 14 age-matched controls . Recording blocks consisted of targets preceded by randomized sequences of standards and by sequences of standards that included a predictive sequence signaling the occurrence of a subsequent target event . RESULTS Both MDD patients and age-matched controls demonstrated a significant reaction time ( RT ) and P3b latency differences between predicted and random targets . However , patients demonstrated a specific prolongation of these measures during processing of predicted targets , as well as an attenuation of P3b amplitudes for the predictive sequence . In addition , patients target N1 amplitudes were attenuated compared with controls . CONCLUSION MDD patients were able to utilize predictive context in order to facilitate processing of deterministic targets , however , this ability was limited compared to controls , as demonstrated by context-dependent P3b deficits . SIGNIFICANCE These findings suggest that patients with major depression have altered processing of local contextual processing .
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Intervention_Physical
EEG
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Intervention_Physical
Recording blocks consisted of targets preceded by randomized sequences of standards and by sequences of standards that included a predictive sequence signaling the occurrence of a subsequent target event
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Intervention_Physical
controls
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Outcome_Mental
Local contextual processing
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Outcome_Mental
local contextual processing
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Outcome_Physical
significant
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Outcome_Mental
reaction time ( RT )
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Outcome_Mental
P3b latency
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Outcome_Physical
differences
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Outcome_Physical
specific
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Outcome_Mental
prolongation
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Outcome_Physical
attenuation of
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Outcome_Mental
P3b amplitudes
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Outcome_Mental
N1 amplitudes
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Outcome_Physical
were attenuated
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Outcome_Mental
utilize predictive context
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Outcome_Adverse-effects
ability was limited
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Outcome_Mental
altered processing of local contextual processing
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Participant_Condition
patients with major depressive disorder ( MDD )
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Participant_Sample-size
15 MDD patients
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Participant_Sample-size
14 age-matched controls