92562
document
Aspartame : neuropsychologic and neurophysiologic evaluation of acute and chronic effects . BACKGROUND Neurobehavioral symptoms have been reported anecdotally with aspartame . OBJECTIVE This study sought to determine whether aspartame can disrupt cognitive , neurophysiologic , or behavioral functioning in normal individuals . DESIGN Forty-eight healthy volunteers completed a randomized , double-blind , placebo-controlled , crossover study . The first month was aspartame free . Subjects then consumed sodas and capsules with placebo , aspartame , or sucrose for 20 d each . Order was randomized and subjects were assigned to either a high- ( 45 mg x kg body wt ( -1 ) x d ( -1 ) ) or low- ( 15 mg x kg body wt ( -1 ) x d ( -1 ) ) dose aspartame group . Neuropsychologic and laboratory testing was done on day 10 of each treatment period to determine possible acute effects and on day 20 for possible chronic effects . RESULTS Plasma phenylalanine concentrations increased significantly during aspartame treatment . Neuropsychologic results ; adverse experiences ; amino acid , insulin , and glucose values ; and electroencephalograms were compared by sex and by treatment . No significant differences were found for any dependent measure . CONCLUSION Large daily doses of aspartame had no effect on neuropsychologic , neurophysiologic , or behavioral functioning in healthy young adults .
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Intervention_Pharmacological
Aspartame
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Intervention_Pharmacological
aspartame
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Intervention_Pharmacological
aspartame
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
aspartame
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Intervention_Control
sodas and capsules with placebo
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Intervention_Pharmacological
aspartame
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Intervention_Pharmacological
sucrose
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Intervention_Pharmacological
aspartame
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Intervention_Pharmacological
aspartame
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Participant_Condition
behavioral functioning
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Participant_Sample-size
Forty-eight
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Participant_Condition
healthy
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Participant_Age
young adults