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document
Results of a prospective randomized study of hepatic artery infusion with 5-fluorouracil versus intravenous 5-fluorouracil in patients with hepatic metastases from colorectal cancer : A Central Oncology Group study . In a controlled , prospectively randomized trial , 74 patients with hepatic metastases from colorectal cancer were randomized to either intra-arterial hepatic artery infusion with 5-fluorouracil ( 5-FU ) or systemic chemotherapy with 5-FU . In 61 acceptable patients , there was no significant difference in terms of response rate , time to progression , duration of the response , and survival rate . Though the response rate for the intra-arterial infusion arm was slightly higher than for the systemic arm , the difference was not significant , and the intra-arterial infusion arm was associated with a greater incidence of nausea , vomiting , diarrhea , in addition to complications of femoral-arterial thrombosis , bleeding , and infection at the catheter site not seen in patients treated by systemic chemotherapy . Patients with an objective response to chemotherapy on either treatment arm survived twice as long as the nonresponders . Long-term survival in one patient , 77 months , can occasionally be achieved in patients with hepatic metastases .
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Intervention_Pharmacological
hepatic artery infusion with 5-fluorouracil
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Intervention_Pharmacological
intravenous 5-fluorouracil
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Intervention_Pharmacological
intra-arterial hepatic artery infusion with 5-fluorouracil ( 5-FU )
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Intervention_Pharmacological
systemic chemotherapy with 5-FU
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Intervention_Physical
systemic chemotherapy
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Intervention_Pharmacological
.
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Outcome_Other
response rate
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Outcome_Other
time to progression
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Outcome_Other
duration of the response
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Outcome_Mortality
survival rate
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Outcome_Other
response rate
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Outcome_Adverse-effects
nausea
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Outcome_Adverse-effects
vomiting
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Outcome_Adverse-effects
diarrhea
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Outcome_Adverse-effects
femoral-arterial thrombosis
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Outcome_Adverse-effects
bleeding
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Outcome_Adverse-effects
infection at the catheter site
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Outcome_Mortality
survived
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Outcome_Mortality
Long-term survival
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Participant_Condition
hepatic metastases
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Participant_Condition
colorectal cancer
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Participant_Sample-size
74
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Participant_Condition
hepatic metastases
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Participant_Condition
colorectal cancer