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document
Antihypertensive effect of single doses of enalapril in hypertensive patients treated with bendrofluazide . This study was designed to investigate the validity of the then current recommendations for initiation of therapy with enalapril in hypertensive patients on treatment with a diuretic . Enalapril in single doses of 10 and 20 mg was given to 13 hypertensive patients on treatment with bendrofluazide 5 mg daily in a randomised , crossover , placebo controlled study . The mean maximal reduction in blood pressure was similar with both doses ( 35/20 mmHg supine , 38/20 mmHg standing ) , occurred on average within 6 h of tablet ingestion , and was not accompanied by any significant change in heart rate . Three patients experienced symptomatic hypotension . In one patient this was incapacitating after 10 mg and precluded exposure to 20 mg . This study shows that in hypertensive patients receiving treatment with diuretics , the addition of enalapril should be undertaken with caution . An optimal starting dose of enalapril in such patients remains to be confirmed .
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Intervention_Pharmacological
enalapril
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Intervention_Pharmacological
bendrofluazide
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Intervention_Pharmacological
enalapril
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Intervention_Pharmacological
Enalapril
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Intervention_Pharmacological
bendrofluazide
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Intervention_Control
placebo
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Outcome_Physical
Antihypertensive effect
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Outcome_Physical
The mean maximal reduction in blood pressure
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Outcome_Physical
heart rate
74482
Outcome_Physical
symptomatic hypotension
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Outcome_Adverse-effects
incapacitating
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Participant_Condition
hypertensive patients
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Participant_Condition
hypertensive
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Participant_Sample-size
13