86130
document
Comparison of rectal midazolam and diazepam for premedication in pediatric dental patients . Rectally administered midazolam ( 0.35 mg/kg ) and diazepam ( 0.70 mg/kg ) were compared with each other and with placebo for preanesthetic medication in children undergoing dental extractions . All rectal medications were very well accepted , but mask acceptance , improvement in anxiety , and sedation were best in the midazolam group . Improvement in anxiety and sedation were significantly better in the two drug groups than in those patients who had received placebo . Thirty minutes after rectal administration of midazolam , patients showed a decrease in both systolic and diastolic blood pressure and heart rate . Although these decreases differed significantly from the premedication values , they were probably of little clinical importance . Only minor adverse effects were observed in this study . Overall rectally administered midazolam appeared to be somewhat more efficacious than diazepam .
86131
Intervention_Pharmacological
rectal midazolam
86132
Intervention_Pharmacological
diazepam
86133
Intervention_Pharmacological
midazolam
86134
Intervention_Pharmacological
diazepam
86135
Intervention_Control
placebo
86136
Intervention_Pharmacological
rectal medications
86137
Intervention_Pharmacological
midazolam
86138
Intervention_Control
placebo
86139
Intervention_Pharmacological
midazolam
86140
Intervention_Pharmacological
midazolam
86141
Intervention_Pharmacological
diazepam
86142
Outcome_Mental
mask acceptance
86143
Outcome_Mental
anxiety
86144
Outcome_Mental
sedation
86145
Outcome_Mental
anxiety
86146
Outcome_Mental
sedation
86147
Outcome_Physical
systolic and diastolic blood pressure and heart rate .
86148
Outcome_Adverse-effects
minor adverse effects
86149
Participant_Age
pediatric
86150
Participant_Condition
dental patients
86151
Participant_Age
children
86152
Participant_Condition
undergoing dental extractions