81117
document
Abdominoperineal resection and anterior resection in the treatment of rectal cancer : results in relation to adjuvant preoperative radiotherapy . The outcome of patients with rectal cancer treated by abdominoperineal or anterior resection , with or without preoperative radiotherapy , was assessed to detect any differences attributable to the operative method and interactions between radiotherapy and type of surgery . The study was based on 1292 patients included in two consecutive controlled randomized trials of preoperative radiotherapy in operable rectal carcinoma . The outcome was not related to surgical method . Radiotherapy increased postoperative mortality and complications and reduced local and distant recurrence , but had no effect on overall survival . Effects of radiotherapy were similar irrespective of the type of surgery , except that the increase in postoperative mortality in irradiated patients was greater in those treated with abdominoperineal resection . Sphincter-saving procedures appear to have no adverse effects on outcome of rectal cancer , but the optimum use of radiotherapy is still to be defined .
81118
Intervention_Physical
Abdominoperineal resection
81119
Intervention_Physical
anterior resection
81120
Intervention_Physical
adjuvant preoperative radiotherapy
81121
Intervention_Physical
abdominoperineal or anterior resection , with or without preoperative radiotherapy
81122
Intervention_Physical
preoperative radiotherapy
81123
Intervention_Physical
radiotherapy
81124
Intervention_Educational
Sphincter-saving procedures
81125
Outcome_Mortality
postoperative mortality
81126
Outcome_Adverse-effects
complications
81127
Outcome_Other
local and distant recurrence
81128
Outcome_Mortality
overall survival
81129
Outcome_Mortality
postoperative mortality
81130
Participant_Condition
rectal cancer
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Participant_Sample-size
1292