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document
Moclobemide , imipramine and placebo in the treatment of major depression . Moclobemide was compared with imipramine and placebo in the treatment of major depressive episodes in 75 outpatients . The dosage of moclobemide ( 25 patients ) was 300 mg daily for the first 5 days , after which it could be increased to 600 mg. Imipramine ( 25 patients ) was given in a dosage starting with 33 mg and gradually increased to 100 mg/day in the first 5 days , after which it could be further increased ; 25 patients received placebo . Both drugs were equally effective as measured by the Hamilton Rating Scale for Depression , the overall assessment of efficacy and the Zung Self-rating Scale , and clearly superior to placebo ; there were no significant differences between the 2 active drugs . Moclobemide was better tolerated than imipramine , and was almost comparable to placebo in this respect .
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Intervention_Pharmacological
Imipramine ( 25 patients ) was given in a dosage starting with 33 mg and gradually increased to 100 mg/day in the first 5 days
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Intervention_Control
placebo .
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Intervention_Pharmacological
Moclobemide
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Intervention_Pharmacological
imipramine
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Outcome_Physical
depression
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Outcome_Physical
Hamilton Rating Scale for Depression
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Outcome_Other
Zung Self-rating Scale
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Outcome_Other
better tolerated
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Participant_Condition
depression
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Participant_Sample-size
75
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Participant_Sample-size
25
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Participant_Sample-size
25
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Participant_Sample-size
25