46982
document
Aztreonam versus gentamicin for short-term prophylaxis in biliary and gastric surgery . Short-term antibiotic prophylaxis was studied in 80 patients undergoing biliary or gastric surgery . The patients were randomized to receive 1 g of aztreonam or 80 mg of gentamicin intravenously 30 minutes before surgery and 8 and 16 hours after surgery . Of samples taken from the abdominal cavity for bacteriologic study , 53 % were culture positive . Wound infections developed in two ( 4.5 % ) of 44 patients receiving aztreonam and in seven ( 19.4 % ) of 36 patients treated with gentamicin . Staphylococcus epidermidis and Enterobacter species were isolated from sites of wound infection in the aztreonam group ; Escherichia coli ( two isolates ) , Pseudomonas aeruginosa ( two isolates ) , Enterobacter species , Klebsiella species , Enterococcus faecalis , and Aeromonas hydrophila were isolated from the gentamicin group . Our data indicate that aztreonam is safe and effective for the prevention of infections following biliary and gastric surgery .
46983
Intervention_Pharmacological
Aztreonam
46984
Intervention_Pharmacological
gentamicin
46985
Intervention_Pharmacological
aztreonam
46986
Intervention_Pharmacological
gentamicin
46987
Intervention_Pharmacological
aztreonam
46988
Intervention_Pharmacological
gentamicin
46989
Intervention_Pharmacological
aztreonam
46990
Intervention_Pharmacological
aztreonam
46991
Outcome_Physical
Wound infections
46992
Outcome_Physical
wound infection
46993
Outcome_Other
safe and effective
46994
Participant_Sample-size
80