86738
document
Around-the-clock intraocular pressure reduction with once-daily application of latanoprost by itself or in combination with timolol . OBJECTIVE To determine whether once-daily , in the morning , topical application of the new ocular hypotensive prostaglandin analogue , latanoprost , yields nocturnal intraocular pressure ( IOP ) reduction similar to its diurnal IOP reducing efficacy . STUDY DESIGN AND PATIENTS Placebo- controlled , randomized , and double-masked study on hospitalized patients with ocular hypertension or glaucoma . Patients in group 1 ( n=9 ) were maintained on twice-daily applications of 0.5 % timolol maleate . Patients in group 2 ( n=10 ) terminated their timolol treatment 3 weeks before the beginning of the study . In both groups the test drug ( 0.005 % latanoprost ) and its vehicle ( placebo ) was applied by hospital staff every morning for 9 days . MEASUREMENTS After 4 days of ambulatory treatment , patients were hospitalized , and IOP values were obtained in the supine and sitting positions with a handheld electronic tonometer ( Tono-Pen XL , Bio-Rad , Glendale , Calif ) and a Goldmann 's applanation tonometer , covering every 2-hour interval , around the clock , but not more than at four time points per day during a 5-day period . RESULTS The mean nocturnal IOPs ( Goldmann 's applanation tonometer ) collected for 5 days were mean +/-SEM 17.9+/-0.6 vs 20.2+/-0.6 mm Hg and 16.8+/-0.3 vs 20.6+/-0.5 mm Hg for the study vs the control eyes in group 1 and group 2 , respectively . These nocturnal IOP reductions were statistically significant ( P < .001 , two-tailed paired Student 's t test ) . The differences between diurnal and nocturnal IOP reductions ( handheld electronic or Goldmann 's applanation tonometer ) were minimal ( > 0.3 mm Hg ) and statistically not significant ( P > .31 , two-tailed paired Student 's t test ) . CONCLUSION Once-daily latanoprost treatment provides uniform circadian ( around-the-clock ) IOP reduction by itself , or in combination with timolol .
86739
Intervention_Pharmacological
latanoprost
86740
Intervention_Pharmacological
combination with timolol
86741
Intervention_Pharmacological
latanoprost
86742
Intervention_Pharmacological
timolol maleate
86743
Intervention_Pharmacological
timolol
86744
Intervention_Pharmacological
latanoprost
86745
Intervention_Control
placebo
86746
Intervention_Pharmacological
latanoprost
86747
Intervention_Pharmacological
timolol
86748
Outcome_Physical
intraocular pressure reduction
86749
Outcome_Physical
nocturnal intraocular pressure ( IOP ) reduction
86750
Outcome_Physical
IOP values
86751
Outcome_Physical
mean nocturnal IOPs ( Goldmann 's applanation tonometer
86752
Outcome_Physical
nocturnal IOP reductions
86753
Outcome_Physical
diurnal and nocturnal IOP reductions
86754
Outcome_Physical
IOP reduction
86755
Participant_Condition
hospitalized patients with ocular hypertension or glaucoma . Patients in group 1 ( n=9 )