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document
Oxytocin increases retention of social cognition in autism . BACKGROUND Oxytocin dysfunction might contribute to the development of social deficits in autism , a core symptom domain and potential target for intervention . This study explored the effect of intravenous oxytocin administration on the retention of social information in autism . METHODS Oxytocin and placebo challenges were administered to 15 adult subjects diagnosed with autism or Asperger 's disorder , and comprehension of affective speech ( happy , indifferent , angry , and sad ) in neutral content sentences was tested . RESULTS All subjects showed improvements in affective speech comprehension from pre- to post-infusion ; however , whereas those who received placebo first tended to revert to baseline after a delay , those who received oxytocin first retained the ability to accurately assign emotional significance to speech intonation on the speech comprehension task . CONCLUSIONS These results are consistent with studies linking oxytocin to social recognition in rodents as well as studies linking oxytocin to prosocial behavior in humans and suggest that oxytocin might facilitate social information processing in those with autism . These findings also provide preliminary support for the use of oxytocin in the treatment of autism .
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Intervention_Pharmacological
Oxytocin
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Intervention_Pharmacological
Oxytocin
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Intervention_Pharmacological
oxytocin
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Intervention_Pharmacological
Oxytocin
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
oxytocin
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Intervention_Pharmacological
oxytocin
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Outcome_Mental
retention of social cognition
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Outcome_Mental
affective speech comprehension
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Outcome_Mental
assign emotional significance to speech intonation
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Outcome_Mental
social recognition
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Outcome_Mental
prosocial behavior
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Participant_Sample-size
15
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Participant_Age
adult
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Participant_Condition
autism or Asperger 's disorder