77737
document
A double-blind crossover comparison of pindolol , metoprolol , atenolol and labetalol in mild to moderate hypertension . 1 This study was designed to compare in a double-blind randomized crossover trial , atenolol , labetalol , metoprolol and pindolol . Considerable differences in dose ( atenolol 138 +/- 13 mg daily ; labetalol 308 +/- 34 mg daily ; metoprolol 234 +/- 22 mg daily ; and pindolol 24 +/-2 mg daily were required to produce similar antihypertensive effects . 3 The overall incidence of side-effects was similar with atenolol , metoprolol and pindolol but was slightly less with labetalol . Sleep disturbances and abnormal dreaming patterns were most frequent with pindolol . 4 There was a significantly greater fall in pulse rate during atenolol and metoprolol treatment periods .
77738
Intervention_Pharmacological
pindolol
77739
Intervention_Pharmacological
metoprolol
77740
Intervention_Pharmacological
atenolol
77741
Intervention_Pharmacological
labetalol
77742
Intervention_Pharmacological
atenolol
77743
Intervention_Pharmacological
labetalol
77744
Intervention_Pharmacological
metoprolol
77745
Intervention_Pharmacological
pindolol
77746
Intervention_Pharmacological
atenolol
77747
Intervention_Pharmacological
labetalol
77748
Intervention_Pharmacological
metoprolol
77749
Intervention_Pharmacological
pindolol
77750
Intervention_Pharmacological
atenolol
77751
Intervention_Pharmacological
metoprolol
77752
Intervention_Pharmacological
pindolol
77753
Intervention_Pharmacological
labetalol
77754
Intervention_Pharmacological
pindolol
77755
Intervention_Pharmacological
atenolol
77756
Intervention_Pharmacological
metoprolol
77757
Outcome_Other
dose
77758
Outcome_Physical
antihypertensive effects
77759
Outcome_Adverse-effects
side-effects
77760
Outcome_Mental
Sleep disturbances
77761
Outcome_Mental
abnormal dreaming patterns
77762
Outcome_Physical
significantly greater fall in pulse rate
77763
Participant_Condition
A double-blind crossover comparison of pindolol , metoprolol , atenolol and labetalol in mild to moderate hypertension .