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Five-year outcome of surgical treatment of migraine headaches . BACKGROUND This study was designed to assess the long-term efficacy of surgical deactivation of migraine headache trigger sites . METHODS One hundred twenty-five volunteers were randomly assigned to the treatment ( n = 100 ) or control group ( n = 25 ) after examination by the team neurologist to ensure a diagnosis of migraine headache . Patients were asked to complete the Medical Outcomes Study 36-Item Short Form Health Survey , Migraine-Specific Quality of Life , and Migraine Disability Assessment questionnaires before treatment and at 12- and 60-month postoperative follow-up . The treatment group received botulinum toxin to confirm the trigger sites ; controls received saline injections . Treated patients underwent surgical deactivation of trigger site ( s ) . Results were analyzed at 1 year ( previously published ) and 5 years postoperatively ( the subject of this report ) . RESULTS Eighty-nine of 100 patients in the treatment group underwent surgery , and 79 were followed for 5 years . Ten patients underwent deactivation of additional ( different ) trigger sites during the follow-up period and were not included in the data analysis . The final outcome with or without inclusion of these 10 patients was not statistically different . Sixty-one ( 88 percent ) of 69 patients have experienced a positive response to the surgery after 5 years . Twenty ( 29 percent ) reported complete elimination of migraine headache , 41 ( 59 percent ) noticed a significant decrease , and eight ( 12 percent ) experienced no significant change . When compared with the baseline values , all measured variables at 60 months improved significantly ( p < 0.0001 ) . CONCLUSION Based on the 5-year follow-up data , there is strong evidence that surgical manipulation of one or more migraine trigger sites can successfully eliminate or reduce the frequency , duration , and intensity of migraine headache in a lasting manner .
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Intervention_Pharmacological
botulinum toxin
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Intervention_Control
saline injections .
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Intervention_Pharmacological
surgical deactivation
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Intervention_Educational
deactivation
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Outcome_Pain
migraine headaches
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Outcome_Physical
migraine headache
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Outcome_Physical
Medical Outcomes Study 36-Item Short Form Health Survey
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Outcome_Other
Migraine-Specific Quality of Life
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Outcome_Physical
Migraine Disability Assessment questionnaires
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Outcome_Physical
positive response
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Outcome_Other
complete elimination of migraine headache
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Outcome_Other
eliminate or reduce the frequency , duration , and intensity of migraine headache
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Participant_Sample-size
One hundred twenty-five
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Participant_Sample-size
treatment ( n = 100 )
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Participant_Sample-size
control group ( n = 25 )
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Participant_Condition
migraine headache
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Participant_Sample-size
100