75475
document
Diclofenac , a nonsteroidal anti-inflammatory drug , decreases proteinuria in some glomerular diseases : a controlled study . Treatment with nonsteroidal anti-inflammatory drugs ( NSAIDs ) was first used in glomerulonephritis ( GN ) in 1966 but its efficiency is still debated . We studied the antiproteinuric effect of such a treatment in a double-blind study . 29 GN patients with normal renal function ( 17 membranoproliferative GN , 12 IgA GN ) were randomly assigned to receive 100 mg/day of diclofenac or placebo for at least 2 months . There was a significant antiproteinuric effect of diclofenac versus placebo with a fall of 70 % in the diclofenac group versus 6 % in the placebo group ( p less than 0.001 with the Mann-Whitney test ) . The median was 3 mg/min at onset and 2.45 mg/min after 2 months treatment with the placebo . In the diclofenac group , it was 2.2 and 0.95 mg/min , respectively ( p less than 0.01 ) . Diclofenac did not significantly increase creatinine levels . Gastric irritation was noted only once . This study establishes the short-term antiproteinuric action of diclofenac . Whether this action affects the final outcome is not yet determined .
75476
Intervention_Pharmacological
Diclofenac
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Intervention_Pharmacological
nonsteroidal anti-inflammatory drugs ( NSAIDs )
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Intervention_Pharmacological
diclofenac
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Intervention_Control
placebo
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Intervention_Pharmacological
diclofenac
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Intervention_Control
placebo
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Intervention_Control
placebo
75483
Intervention_Pharmacological
diclofenac
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Intervention_Pharmacological
Diclofenac
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Outcome_Physical
antiproteinuric effect
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Outcome_Physical
antiproteinuric effect
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Outcome_Physical
creatinine levels
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Outcome_Physical
Gastric irritation
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Outcome_Physical
short-term antiproteinuric action
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Participant_Condition
glomerular diseases
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Participant_Condition
glomerulonephritis
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Participant_Sample-size
29 GN
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Participant_Condition
normal renal function
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Participant_Sample-size
17
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Participant_Sample-size
12