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document
Treatment of duodenal ulcer with low-dose antacids . The aim of the present investigation was to compare the efficacy of a low-dose antacid ( Maalox 70 , 280 mmol/day ) with that of the H2-receptor antagonist cimetidine ( Tagamet , 200 mg three times daily and 400 mg/day ) after 14 and 28 days in the treatment of duodenal ulcer . The prospective multicentre study included 171 patients with endoscopically confirmed duodenal ulcers . The patients were randomly assigned to the treatment groups with antacid containing Mg and Al hydroxide ( M ) ( 4 X 70 mmol/day ; n = 86 ) or to the group receiving cimetidine ( T ) ( 1000 mg/day ; n = 85 ) . The two treatment groups were matched for age , sex , drinking and smoking habits , and drug use . Endoscopic examinations were carried out before the start of treatment and 14 days later . If the ulcer was still present at this time , the second endoscopic examination was done after a further 14 days . Endoscopically , the ulcer had healed at 14 days in 38.8 % ( M ) and in 34.9 % ( T ) and at 28 days in 80.0 % ( M ) and 74.7 % ( T ) , respectively . The healing rate did not differ significantly between the two treatment groups . Complaints , measured as percentage of days per week with upper abdominal pain , were significantly reduced in both groups . No significant differences were found between the two treatment groups with regard to pain relief or side effects . Treatment had to be abandoned in one patient receiving antacid because of diarrhoea and in one patient receiving cimetidine because of the absence of any response . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
low-dose antacids
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Intervention_Pharmacological
low-dose antacid ( Maalox 70
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Intervention_Pharmacological
H2-receptor antagonist cimetidine ( Tagamet
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Intervention_Pharmacological
antacid containing Mg and Al hydroxide ( M ) ( 4
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Intervention_Pharmacological
cimetidine
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Outcome_Physical
healed
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Outcome_Physical
healing rate
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Outcome_Other
Complaints
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Outcome_Pain
upper abdominal pain
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Outcome_Pain
pain relief
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Outcome_Adverse-effects
side effects
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Participant_Condition
duodenal ulcer
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Participant_Condition
duodenal ulcer
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Participant_Sample-size
171
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Participant_Condition
duodenal ulcers