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document
The effect of eradication of Helicobacter pylori upon the duodenal ulcer recurrence -- a 24 month follow-up study . OBJECTIVES To evaluate the effect of eradication of Helicobacter pylori ( H.pylori ) in the patients with duodenal ulcer ( Du ) upon the DU recurrence . METHODS This study was performed for 190 patients with DU . Four different methods-microscopy of Gram stained mucosal smear , specific culture , biopsy urease test , histology of H & E staining-were taken for identifying colonization of H. pylori before treatment , and for finding the eradication of H. pylori 4 weeks after completion of therapy in each treatment group ( cometidine , omeprazole , colloidal bismuth subcitrate ( CBS ) , CBS and metronidazole double therapy , CBS , metronidazole and amoxicillin triple therapy ) . To detect DU recurrence , the gastroscopy was performed at 6 , 12 , 18 , and 24 months after therapy . RESULTS The eradication rate of the cimetidine group the omeprazole group , and the CBS group were 0 % , 7.7 % , 0 % , respectively , and that of the double therapy group and the triple therapy group were 44.4 % and 89.3 % , respectively . Seventy three patients who were followed up for 2 years were categorized into two groups according to the eradication of H. pylori . The recurrence rate was 3.2 % both in 1 year and 2 years later in the former group-one consisting of 31 patients with H. pylori eradicated , while the recurrence rate was 57.1 % in 1 year and 78.6 % in 2 years later , in the latter group-the other of 42 patients with H. pylori not eradicated . CONCLUSION The eradication of H. pylori in patients with DU reduces the recurrence of DU .
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Intervention_Pharmacological
( cometidine , omeprazole , colloidal bismuth subcitrate ( CBS ) , CBS and metronidazole double therapy , CBS , metronidazole and amoxicillin triple therapy )
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Intervention_Pharmacological
cimetidine
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Intervention_Pharmacological
omeprazole
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Intervention_Pharmacological
double therapy
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Outcome_Physical
duodenal ulcer recurrence
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Outcome_Other
eradication
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Outcome_Physical
DU recurrence
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Outcome_Other
Gram stained mucosal smear
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Outcome_Physical
,
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Outcome_Other
specific culture
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Outcome_Other
biopsy urease test
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Outcome_Other
histology of H & E staining-were
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Outcome_Physical
DU recurrence
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Outcome_Other
gastroscopy
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Outcome_Other
eradication rate
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Outcome_Physical
eradication of H. pylori
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Outcome_Physical
recurrence rate
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Outcome_Physical
recurrence rate
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Outcome_Physical
recurrence of DU
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Participant_Condition
duodenal ulcer ( Du )
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Participant_Sample-size
190
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Participant_Condition
DU
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Participant_Sample-size
Seventy three
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Participant_Sample-size
31
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Participant_Sample-size
42
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Participant_Condition
H. pylori
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Participant_Condition
DU