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document
Effects of resistive exercise on skeletal muscle in marrow transplant recipients receiving total parenteral nutrition . Skeletal muscle protein loss occurs during marrow transplantation despite total parenteral nutrition . To determine if muscle atrophy could be minimized with exercise therapy , 30 patients undergoing marrow transplantation for acute leukemia completed a prospective randomized trial to receive : ( 1 ) no therapy ( controls ) , ( 2 ) physical therapy thrice weekly ( PT3 ) , or ( 3 ) physical therapy five times weekly ( PT5 ) . Patients were studied through 35 days posttransplant . Muscle protein status and turnover was assessed by weekly nitrogen balance , and creatinine and 3-methylhistidine excretion . Results favored a muscle protein-sparing effect of exercise , as a significant decrease in creatinine excretion in controls only suggested muscle protein loss associated with inactivity . Changes in arm muscle area correlated with energy , but not protein intake . Large individual variation , inadequate nutritional support and differences in admission arm muscle area may have clouded these results .
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Intervention_Physical
resistive exercise
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Intervention_Physical
exercise therapy
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Intervention_Control
no therapy ( controls )
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Intervention_Physical
( 2 ) physical therapy thrice weekly ( PT3 ) , or ( 3 ) physical therapy five times weekly
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Intervention_Physical
exercise
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Outcome_Physical
Skeletal muscle protein loss
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Outcome_Physical
muscle atrophy
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Outcome_Physical
Muscle protein status and turnover
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Outcome_Physical
weekly nitrogen balance
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Outcome_Physical
creatinine
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Outcome_Physical
3-methylhistidine excretion
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Outcome_Physical
creatinine excretion
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Outcome_Physical
muscle protein loss
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Outcome_Physical
arm muscle area
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Participant_Condition
marrow transplant recipients receiving total parenteral nutrition .