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document
A trial of D-cycloserine to treat stereotypies in older adolescents and young adults with autism spectrum disorder . OBJECTIVES Autism spectrum disorders ( ASDs ) have core impairments in social communication as well as the presence of repetitive , stereotypic behaviors and restricted interests . Older adolescents and young adults are particularly impacted by these deficits . Preclinical data implicate glutamatergic dysfunction in the pathophysiology of ASDs . D-Cycloserine ( DCS ) , a partial glycineB agonist at the N-methyl-D-aspartic acid receptor site , has been shown to improve sociability in mouse models and a small human study . The sensitivity of the obligatory glycineB co-agonist binding site may change with daily administration of DCS as a result of agonist-induced desensitization . The efficacy of a " pulsed " once-weekly administration versus " daily " administration of DCS was compared . METHODS Males and females , ages 14 to 25 years , with a Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition Text Revision diagnosis of an ASD were enrolled in a double-blind , randomized 10-week trial consisting of 8 weeks of active drug with either weekly or daily administration of 50 mg of DCS followed by a 2-week follow-up visit . RESULTS For the purposes of this study , no statistical or clinical differences existed between the 2 dosage groups on the Aberrant Behavior Checklist subscale 3 , which measures stereotypies/repetitive movements . When combining groups , a statistically significant decrease of 37 % was found from baseline to week 8 when study drug was completed using a linear mixed effects model ( P = 0.003 ) . CONCLUSIONS D-Cycloserine was shown to be effective in improving stereotypic symptoms in older adolescents and young adults with ASDs measured by the Aberrant Behavior Checklist subscale 3 . In addition , DCS was safe and well tolerated .
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Intervention_Pharmacological
D-cycloserine
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Intervention_Pharmacological
D-Cycloserine ( DCS )
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Intervention_Pharmacological
DCS
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Intervention_Pharmacological
D-Cycloserine
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Intervention_Pharmacological
DCS
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Outcome_Other
efficacy
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Outcome_Mental
Aberrant Behavior Checklist subscale 3 , which measures stereotypies/repetitive movements .
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Outcome_Mental
stereotypic symptoms
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Outcome_Mental
Aberrant Behavior Checklist subscale 3 .
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Outcome_Other
safe and well tolerated .
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Participant_Age
older adolescents
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Participant_Age
young adults
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Participant_Condition
autism spectrum disorder
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Participant_Sex
Males
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Participant_Sex
females
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Participant_Age
ages 14 to 25 years ,
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Participant_Condition
Diagnostic and Statistical Manual of Mental Disorders
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Participant_Condition
Fourth Edition Text Revision diagnosis of an ASD