69885
document
Three-Arm Randomized Phase III Trial : Quality Aloe and Placebo Cream Versus Powder as Skin Treatment During Breast Cancer Radiation Therapy . BACKGROUND The efficacy of aloe extract in reducing radiation-induced skin injury is controversial . The purpose of the present 3-arm randomized trial was to test the efficacy of quality-tested aloe extract in reducing the severity of radiation-induced skin injury and , secondarily , to examine the effect of a moist cream versus a dry powder skin care regimen . MATERIALS AND METHODS A total of 248 patients with breast cancer were randomized to powder , aloe cream , or placebo cream . Acute skin toxicity was scored weekly and after treatment at weeks 1 , 2 , and 4 using a modified 10-point Catterall scale . The patients scored their symptom severity using a 6-point Likert scale and kept an acute phase diary . RESULTS The aloe formulation did not reduce acute skin toxicity or symptom severity . Patients with a greater body mass index were more likely to develop acute skin toxicity . A similar pattern of increased skin reaction toxicity occurred with both study creams compared with the dry powder regimen . CONCLUSION No evidence was found to support prophylactic application of quality aloe extract or cream to improve the symptoms or reduce the skin reaction severity . Our results support a dry skin care regimen of powder during radiation therapy .
69886
Intervention_Control
Aloe and Placebo
69887
Intervention_Pharmacological
Powder
69888
Intervention_Pharmacological
aloe extract
69889
Intervention_Pharmacological
moist cream
69890
Intervention_Pharmacological
dry powder skin care regimen .
69891
Intervention_Pharmacological
powder , aloe cream
69892
Intervention_Control
placebo cream .
69893
Intervention_Pharmacological
aloe extract
69894
Participant_Condition
Breast Cancer
69895
Participant_Sample-size
248
69896
Participant_Condition
breast cancer