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document
Transdermal nitroglycerin in angina pectoris : efficacy of intermittent application . Continuous application of transdermal nitroglycerin appears to result in tolerance to the antianginal effect . In a double-blind study the effects of continuous ( 24 h/day ) and intermittent ( 16 h/day ) application of transdermal nitroglycerin in a dosage of 10 mg/day were compared with the effects of placebo in 12 patients with chronic stable angina receiving treatment with beta-adrenergic blocking or calcium channel blocking agents . Exercise performance was assessed 2 to 4 hours after initial application and after 1 week of each treatment given in random order with a 3 day interval between treatments . Exercise time to onset of angina , total exercise duration and time to 1 mm ST segment depression were all significantly increased after initial application during the continuous and intermittent treatment periods . These increases were maintained after 1 week of intermittent but not continuous treatment . Thus the benefit of initial application of transdermal nitroglycerin is maintained with intermittent treatment and a daily nitrate-free interval , whereas tolerance to antianginal effect occurs with continuous treatment .
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Intervention_Pharmacological
Transdermal nitroglycerin
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Intervention_Pharmacological
transdermal nitroglycerin
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Intervention_Pharmacological
transdermal nitroglycerin in
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Intervention_Control
placebo
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Intervention_Pharmacological
beta-adrenergic blocking
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Intervention_Pharmacological
calcium channel blocking agents
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Intervention_Pharmacological
transdermal nitroglycerin
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Outcome_Other
tolerance to the antianginal effect
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Outcome_Physical
Exercise performance
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Outcome_Physical
Exercise time to onset of angina , total exercise duration and time to 1 mm ST segment depression
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Outcome_Other
tolerance to antianginal effect
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Participant_Condition
angina pectoris
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Participant_Sample-size
12