76865
document
[ Results of a cooperative prospective study of treatment of primary digestive localizations of non-Hodgkin 's lymphoma ] . We report the results of chemotherapy treatment in 82 patients presenting with primary digestive lymphoma and included in a study conducted between October 1977 and October 1985 . There were 31 gastric lymphoma , 18 small intestinal lymphomas , and 19 with multiple involvement : 63 patients had had a surgical staging with total tumor resection in 15 cases . Nineteen patients with limited disease ( ID and IID ) were randomly assigned to either a 3-week chemotherapy regimen associated with whole abdominal radiotherapy or chemotherapy for 3 years . Twenty-seven stage IIID and thirty-six stage IV were treated with chemotherapy alone for 3 years . Low grade lymphomas ( 16 patients ) received a cyclophosphamide , vincristine , prednisone association . Intermediate ( 56 patients ) and high grade ( 10 patients ) lymphomas received cyclophosphamide , vincristine , adriamycin , prednisone . The overall complete remission obtained was 63 p. 100 ( 51 patients ) with 17 patients in relapse within 6 to 40 months . Overall survival was 46 p. 100 at 5 years . Survival was dependent on abdominal extension , histologic grade according to the new working formulation used for lymph-node lymphomas , initial localization ( gastric lymphomas have the best survival ) and achievement of complete remission . Chemotherapy is an effective treatment for primary digestive lymphomas . The role of surgery in the management of lymphomas has to be defined by further studies .
76866
Intervention_Pharmacological
chemotherapy treatment
76867
Intervention_Physical
chemotherapy
76868
Intervention_Physical
whole abdominal radiotherapy
76869
Intervention_Physical
chemotherapy
76870
Intervention_Physical
chemotherapy
76871
Intervention_Pharmacological
cyclophosphamide
76872
Intervention_Pharmacological
vincristine
76873
Intervention_Pharmacological
prednisone association
76874
Intervention_Pharmacological
cyclophosphamide
76875
Intervention_Pharmacological
vincristine
76876
Intervention_Pharmacological
adriamycin
76877
Intervention_Pharmacological
prednisone
76878
Intervention_Physical
Chemotherapy
76879
Outcome_Physical
overall complete remission
76880
Outcome_Physical
relapse
76881
Outcome_Mortality
Overall survival
76882
Outcome_Mortality
Survival
76883
Outcome_Physical
abdominal extension , histologic grade according to the new working formulation used for lymph-node lymphomas , initial localization
76884
Outcome_Physical
complete remission
76885
Outcome_Other
treatment
76886
Participant_Condition
non-Hodgkin 's lymphoma ]
76887
Participant_Sample-size
82
76888
Participant_Condition
primary digestive lymphoma
76889
Participant_Sample-size
31
76890
Participant_Condition
gastric lymphoma
76891
Participant_Sample-size
18
76892
Participant_Condition
small intestinal lymphomas
76893
Participant_Sample-size
19
76894
Participant_Condition
multiple involvement
76895
Participant_Sample-size
Nineteen
76896
Participant_Condition
limited disease ( ID and IID )
76897
Participant_Sample-size
Twenty-seven
76898
Participant_Condition
stage IIID
76899
Participant_Sample-size
thirty-six
76900
Participant_Condition
stage IV