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document
A randomized clinical trial of St. John 's wort for smoking cessation . INTRODUCTION St. John 's wort ( SJW ) is a widely used herbal supplement . The predominant mechanism ( s ) accounting for the activity of SJW in vivo are , however , unclear . The purpose of this study was to investigate the efficacy of SJW for smoking cessation . METHODS We conducted a randomized , blinded , placebo-controlled , three-arm , dose-ranging clinical trial . A total of 118 subjects were randomly allocated to receive SJW 300 mg , 600 mg , or a matching placebo tablet 3 times a day combined with a behavioral intervention for 12 weeks . Self-reported smoking abstinence was biochemically confirmed with expired air carbon monoxide . RESULTS Mean age of the study participants was 37.6 +/- 12.4 years ; they smoked an average of 20.0 +/- 6.6 cigarettes per day for 20 +/- 12.1 years . The study dropout rate was high ( 43 % ) . By intention-to-treat analysis , no significant differences were observed in abstinence rates at 12 and 24 weeks between SJW dose groups and placebo . SJW did not attenuate withdrawal symptoms among abstinent subjects . Abstinence rates did not differ by study group among subjects who took at least 75 % of their study medication . No significant side-effects were noted with SJW . CONCLUSIONS In this randomized trial , SJW did not increase smoking abstinence rates . Our data , in combination with data from other studies , suggest that SJW has little role in the treatment of tobacco dependence .
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Intervention_Pharmacological
John 's wort ( SJW )
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Intervention_Pharmacological
SJW
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Intervention_Pharmacological
SJW 300 mg , 600 mg
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Intervention_Control
placebo
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Intervention_Psychological
combined with a behavioral intervention for 12 weeks .
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Intervention_Pharmacological
SJW
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Intervention_Pharmacological
SJW .
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Intervention_Pharmacological
SJW
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Outcome_Mental
smoking cessation .
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Outcome_Mental
smoking cessation
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Outcome_Mental
smoking abstinence
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Outcome_Other
expired air carbon monoxide
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Outcome_Mental
abstinence
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Outcome_Adverse-effects
withdrawal symptoms
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Outcome_Mental
Abstinence rates
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Outcome_Mental
abstinence