22719
document
Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children . This randomized , placebo-controlled trial investigated the tolerance , efficacy , and nutritional benefit of combining chemotherapeutic treatment of intestinal helminths and lymphatic filariasis . Children were infected with Ascaris ( 30.7 % ) , Trichuris ( 53.4 % ) , and hookworm ( 9.7 % ) with 69.9 % having more than one of these parasites . A total of 15.8 % of the children had Wuchereria bancrofti microfilariae . Children were randomly assigned treatment with placebo , albendazole ( ALB ) , diethylcarbamazine ( DEC ) , or combined therapy . The combination of DEC/ALB reduced microfilarial density compared with placebo , ALB , or DEC ( P < or = 0.03 ) . Albendazole and DEC/ALB reduced the prevalence of Ascaris , Trichuris , and hookworm more than placebo or DEC ( P < or = 0.03 ) . Among Trichuris-infected children , those receiving ALB and DEC/ALB demonstrated greater gains in weight compared with placebo ( P < or = 0.05 ) . Albendazole and DEC/ALB were equally efficacious in treating intestinal helminths and for children with W. bancrofti microfilaremia , DEC/ALB was more effective than DEC , with no increase in severity of adverse reactions .
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Intervention_Pharmacological
combined diethylcarbamazine and albendazole
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Intervention_Control
placebo-controlled
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Intervention_Control
placebo
22723
Intervention_Pharmacological
albendazole ( ALB )
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Intervention_Pharmacological
diethylcarbamazine ( DEC ) ,
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Intervention_Pharmacological
combined therapy
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Intervention_Pharmacological
Albendazole
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Intervention_Pharmacological
DEC/ALB
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Intervention_Pharmacological
ALB
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Intervention_Pharmacological
DEC/ALB
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Intervention_Control
placebo
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Intervention_Pharmacological
Albendazole
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Intervention_Pharmacological
DEC/ALB
22733
Intervention_Pharmacological
DEC/ALB
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Intervention_Pharmacological
DEC
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Outcome_Other
Tolerance and efficacy
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Outcome_Other
The combination of DEC/ALB reduced microfilarial density compared with placebo , ALB , or DEC ( P < or = 0.03 ) .
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Outcome_Physical
Albendazole and DEC/ALB reduced the prevalence of Ascaris , Trichuris , and hookworm more than placebo or DEC ( P < or = 0.03 ) . Among Trichuris-infected children , those receiving ALB and DEC/ALB demonstrated greater gains in weight compared with placebo ( P < or = 0.05 ) .
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Outcome_Other
Albendazole and DEC/ALB were equally efficacious in treating intestinal helminths and for children with W.
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Outcome_Adverse-effects
bancrofti microfilaremia , DEC/ALB was more effective than DEC , with no increase in severity of adverse reactions .
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Participant_Condition
Wuchereria bancrofti and intestinal helminth infections
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Participant_Age
children
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Participant_Age
Children
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Participant_Condition
infected with Ascaris ( 30.7 % ) , Trichuris ( 53.4 % ) , and hookworm ( 9.7 % ) with 69.9 % having more than one of these parasites
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Participant_Age
children
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Participant_Condition
Wuchereria bancrofti microfilariae
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Participant_Age
Children
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Participant_Condition
Trichuris-infected
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Participant_Age
children
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Participant_Age
children
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Participant_Condition
bancrofti microfilaremia