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document
Sedation depth during spinal anesthesia and survival in elderly patients undergoing hip fracture repair . Low intraoperative Bispectral Index ( BIS ) values may be associated with increased mortality . In a previously reported trial to prevent delirium , we randomized patients undergoing hip fracture repair under spinal anesthesia to light ( BIS > 80 ) or deep ( BIS approximately 50 ) sedation . We analyzed survival of patients in the original trial . Among all patients , mortality was equivalent across sedation groups . However , among patients with serious comorbidities ( Charlson score > 4 ) , 1-year mortality was reduced in the light ( 22.2 % ) vs deep ( 43.6 % ) sedation group ( hazard ratio [ HR ] , 0.43 ; 95 % confidence interval , 0.19-0.97 ; P = 0.04 ) during spinal anesthesia . Similarly , among patients with Charlson score > 6 , 1-year mortality was reduced in the light ( 28.6 % ) vs deep ( 52.6 % ) sedation group ( HR 0.33 ; 95 % confidence interval , 0.12-0.94 ; P = 0.04 ) during spinal anesthesia . Further research on reduced mortality after light sedation during spinal anesthesia is needed .
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Intervention_Pharmacological
spinal anesthesia
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Intervention_Pharmacological
spinal anesthesia
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Intervention_Pharmacological
light ( BIS > 80 )
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Intervention_Pharmacological
deep ( BIS approximately 50 )
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Intervention_Other
light
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Intervention_Other
deep
65430
Intervention_Pharmacological
sedation
65431
Intervention_Pharmacological
light
65432
Intervention_Pharmacological
deep
65433
Intervention_Pharmacological
sedation
65434
Intervention_Pharmacological
spinal anesthesia
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Intervention_Pharmacological
light sedation
65436
Intervention_Pharmacological
spinal anesthesia
65437
Outcome_Physical
Sedation depth
65438
Outcome_Physical
intraoperative Bispectral Index ( BIS ) values
65439
Outcome_Physical
hip fracture repair
65440
Outcome_Mortality
survival
65441
Outcome_Mortality
mortality
65442
Outcome_Mortality
1-year mortality
65443
Outcome_Mortality
1-year mortality
65444
Outcome_Mortality
reduced mortality
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Participant_Condition
elderly patients undergoing hip fracture repair .