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document
Effects of adjunctive zonisamide treatment on weight and body mass index in children with partial epilepsy . BACKGROUND Zonisamide has been associated with weight loss in children and adults . AIMS OF THE STUDY To assess the effects of adjunctive zonisamide on weight and body mass index ( BMI ) in children with partial epilepsy . METHODS A subanalysis was conducted of a Phase III trial and extension study , in which children with partial epilepsy received adjunctive zonisamide ( target dose 8 mg/kg/day ; maximum 500 mg/day ) . Changes in weight were correlated with skeletal development and sexual maturation . RESULTS Overall , 179 children ( 93 male , 86 female ; age 6-18 years ) received zonisamide ( mean duration 370.6 days ) . Weight loss ≥ 5 % was reported for 64 of 179 ( 35.8 % ) zonisamide-treated children . Of these , 46.9 % were overweight/obese at study entry , compared with 23.4 % at study end ( P = 0.0007 ) ; 48.4 % had normal weight at study entry , compared with 65.6 % at study end ( P = 0.03 ) . Three patients were underweight at study entry , and four more became underweight by study end . No consistent correlations between weight loss and skeletal development or sexual maturation were observed . CONCLUSIONS Approximately one-third of children treated with zonisamide experienced ≥ 5 % weight loss . Weight loss was most apparent in children with high baseline BMI values and did not appear to be associated with any consistent effects on growth and development .
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Intervention_Pharmacological
zonisamide
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Intervention_Pharmacological
Zonisamide
70126
Intervention_Pharmacological
zonisamide
70127
Intervention_Pharmacological
adjunctive zonisamide
70128
Intervention_Pharmacological
zonisamide
70129
Outcome_Physical
weight and body mass index
70130
Outcome_Physical
weight
70131
Outcome_Physical
weight and body mass index ( BMI )
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Outcome_Physical
weight
70133
Outcome_Physical
Weight loss ≥ 5 %
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Outcome_Physical
were overweight/obese
70135
Outcome_Physical
normal weight
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Outcome_Physical
were underweight
70137
Outcome_Physical
became underweight
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Outcome_Physical
between weight loss and skeletal development or sexual maturation
70139
Outcome_Physical
experienced ≥ 5 % weight loss
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Outcome_Physical
Weight
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Participant_Age
children
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Participant_Condition
partial epilepsy
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Participant_Condition
weight loss
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Participant_Age
children
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Participant_Age
children
70146
Participant_Age
children
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Participant_Sample-size
179
70148
Participant_Age
children
70149
Participant_Sample-size
93
70150
Participant_Sex
male
70151
Participant_Sample-size
86
70152
Participant_Sex
female
70153
Participant_Age
age 6-18 years )