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document
The impact of daily sodium intake on posttransplant hypertension in kidney allograft recipients . INTRODUCTION Posttransplant hypertension is a well-known risk factor for long-term allograft failure and mortality in kidney recipients . Although dietary sodium restriction is a widely recommended nonpharmacological measure for control of blood pressure ( BP ) , no detailed investigation has been conducted regarding the impact of dietary sodium restriction on this condition . METHODS Thirty-two patients on antihypertensive treatment completed the study . They were randomly divided into two groups : controls ( group 1 ) versus strict sodium diet ( group 2 ; 80 to 100 mmol sodium daily ) . After randomization , 24-hour urine for sodium measurement , BP , and allograft functions were recorded at baseline and after 3 months . BP treatment was reevaluated at each visit throughout the study . RESULTS At baseline , there was no significant difference in age , sex , serum creatinine , systolic and diastolic BP , antihypertensive drugs , or 24-hour urinary sodium levels between the groups . After 3 months , daily urinary sodium excretion ( from 190+/-75 to 106+/-48 mEq/d , P < .0001 ) , systolic BP ( from 146+/-21 to 116+/-11 mm Hg ) , and diastolic BP ( from 89+/-8 to 72+/-10 mm Hg ) had significantly decreased in group 2 , while no significant changes were observed in group 1 . CONCLUSION Low sodium intake in combination with antihypertensive treatment appears to efficiently control BP in kidney allograft recipients with hypertension . Twenty-four-hour urinary sodium excretion should be checked regularly in these patients as a useful marker to indicate whether the patient complies with low sodium intake .
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Intervention_Pharmacological
sodium
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Intervention_Control
controls
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Intervention_Other
strict sodium diet
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Intervention_Pharmacological
sodium
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Outcome_Physical
posttransplant hypertension
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Outcome_Physical
Posttransplant hypertension
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Outcome_Physical
blood pressure ( BP )
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Outcome_Physical
24-hour urine for sodium measurement , BP , and allograft functions
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Outcome_Physical
serum creatinine
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Outcome_Physical
systolic
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Outcome_Physical
diastolic BP
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Outcome_Physical
antihypertensive drugs
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Outcome_Physical
24-hour urinary sodium levels
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Outcome_Physical
daily urinary sodium excretion
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Outcome_Physical
systolic BP
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Outcome_Physical
diastolic BP
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Outcome_Physical
control BP
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Participant_Condition
posttransplant hypertension in kidney allograft recipients .
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Participant_Age
kidney recipients .
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Participant_Condition
Thirty-two patients on antihypertensive treatment completed the study .
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Participant_Condition
kidney allograft recipients