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document
Pharmacokinetics of naproxen after oral administration of two tablet formulations in healthy volunteers . The pharmacokinetics of two naproxen tablet formulations were compared after oral administration . The 250-mg naproxen tablets , tablet I from AFI , Oslo , Norway , and tablet II Naprosyn , Astra-Syntex , were taken by 12 healthy volunteers in a randomized two-period crossover study . Plasma levels of naproxen were measured by a sensitive and specific HPLC method . The data were analyzed by means of two-way analysis of variance to test for significant differences between tablet formulation and differences between the first and second trial periods . Rapid absorption , with most Cmax values from 50-60 micrograms/ml reached within 1.5-3 h , was found for both tablet formulations . No significant difference was found in the rate and extent of absorption between the two formulations : the relative bioavailability of tablet I compared to tablet II was 1.05 +/- 0.21 ( mean +/- SD ) . The naproxen concentration 2 h after ingestion and the Cmax were higher on the second occasion , regardless of preparation , suggesting that the subjects were clinically different on the two occasions .
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Intervention_Pharmacological
naproxen
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Intervention_Pharmacological
naproxen
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Intervention_Pharmacological
250-mg naproxen tablets
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Intervention_Pharmacological
naproxen
79915
Intervention_Pharmacological
naproxen
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Outcome_Other
sensitive and specific HPLC method
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Outcome_Physical
Rapid absorption
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Outcome_Physical
Cmax values
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Outcome_Physical
difference
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Outcome_Other
rate and extent of absorption
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Outcome_Other
bioavailability
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Outcome_Physical
naproxen concentration
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Outcome_Other
clinically different
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Participant_Sample-size
12