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document
Comparison of injection comfort of a new category of cohesive hyaluronic acid filler with preincorporated lidocaine and a hyaluronic acid filler alone . BACKGROUND A smooth , cohesive , 24-mg/mL hyaluronic acid ( HA ) gel with uniform consistency , even flow characteristics , and extended duration was designed for injection into the mid to deep dermis . OBJECTIVE To compare injection pain of a HA gel with preincorporated lidocaine with that with a non-lidocaine formulation . METHODS & MATERIALS This double-blind study at three centers enrolled 60 subjects , injected with both products , randomly assigned to left or right nasolabial fold . The injecting physician assessed severity of pain and ease of injection . Subjects used a visual analog scale ( 0-10 ) for pain assessment . Adverse events were recorded . RESULTS Physician assessment of injection pain was none or mild in 81 % of HA gel injections with preincorporated lidocaine and 36 % of HA-alone injections ( p < .001 ) . Mean pain assessment by subjects was 3.6 for HA+lidocaine and 5.8 for HA alone ( p < .001 ) . Ninety-five percent of the injections were considered easy or very easy ; a greater percentage of HA+lidocaine injections were rated very easy . Mild to moderate adverse events were reported for both products . CONCLUSION The smooth , cohesive HA gel with preincorporated lidocaine increased subject comfort during treatment and improved the injection experience .
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Intervention_Pharmacological
hyaluronic acid filler
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
hyaluronic acid filler alone
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Intervention_Pharmacological
hyaluronic acid ( HA ) gel
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Intervention_Pharmacological
HA gel with preincorporated lidocaine
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
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Outcome_Other
injection comfort
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Outcome_Pain
pain
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Outcome_Other
ease of injection
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Outcome_Pain
injection pain
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Outcome_Pain
Mean pain assessment
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Outcome_Other
subject comfort
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Outcome_Physical
injection experience
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Participant_Condition
injection comfort
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Participant_Condition
cohesive hyaluronic acid filler
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Participant_Sample-size
60
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Participant_Condition
pain assessment