17255
document
[ Cardiac protection is a clinical evidence ] . AIM Anaesthetics may have protective effect against myocardial ischemia . We aimed to investigate if sevoflurane administration could exert myocardial protection during following coronary occlusion in patients with coronary artery disease . METHODS a ) . EXPERIMENTAL DESIGN prospective , randomized study . b ) . SETTING University Hospital , cardiac surgical operative theatre . c ) . PATIENTS 42 patients with coronary artery disease , scheduled to undergo coronary surgery . INCLUSION CRITERIA severe coronary stenosis of anterior descending coronary artery ; no collateral flow on angiography ; at least two normokinetic segments in the myocardial region supplied by the vessel being bypassed . PATIENTS were randomized to receive ( group S ) or not ( group C ) sevoflurane administration for 15 min just before coronary occlusion . d ) . INTERVENTIONS Transoesophageal Tissue Doppler echocardiographic examination of myocardial systolic and early diastolic velocities in both groups basally and 60 s after coronary occlusion by the surgeon . e ) . MEASURES systolic and early diastolic velocities were registered by Tissue Doppler from a long-axis view of the interventricular septum or the anterior wall of the left ventricle . RESULTS In group C a significant reduction of systolic and diastolic intramyocardial velocities was found during myocardial ischemia due to coronary occlusion . CONCLUSION Treatment with sevoflurane before coronary occlusion seem effective in reducing functional myocardial impairment due to ischemia .
17256
Intervention_Pharmacological
to receive ( group S ) or not ( group C ) sevoflurane
17257
Intervention_Physical
Transoesophageal Tissue Doppler echocardiographic examination of myocardial systolic
17258
Intervention_Surgical
early diastolic velocities in both groups basally and 60 s after coronary occlusion by the surgeon
17259
Outcome_Physical
myocardial protection
17260
Outcome_Physical
systolic and early diastolic velocities
17261
Outcome_Physical
systolic and diastolic intramyocardial velocities
17262
Outcome_Physical
functional myocardial impairment
17263
Participant_Condition
coronary artery disease
17264
Participant_Sample-size
42
17265
Participant_Condition
severe coronary stenosis of anterior descending coronary artery
17266
Participant_Condition
no collateral flow on angiography
17267
Participant_Condition
at least two normokinetic segments in the myocardial region supplied by the vessel being bypassed