80334
document
Corticosteroid-induced osteopenia and vitamin D metabolism . Effect of vitamin D2 , calcium phosphate and sodium fluoride administration . Thirty-one patients scheduled for long-term ( 24 weeks ) treatment with prednisone in comparatively high doses were randomly allocated to two further treatment groups . Group A received prednisone plus 'triple-treatment ' ( vitamin D2 45000 iu twice weekly , sodium fluoride 50 mg and calcium phosphate 4.5 g daily ) , group B received only prednisone . The study was undertaken in order to evaluate the effect of prednisone- and triple-treatment upon bone mineral content ( BMC ) and vitamin D metabolism . The groups were comparable with regard to age , sex and prednisone dose . BMC fell rapidly and similarly in both groups , demonstrating that the triple-treatment has no preventive effect on corticosteroid induced osteopenia . Serum concentrations of 25OHD2 , 25OHD3 and 1,25 ( OH ) 2D were unchanged in group B ( without triple-treatment ) , whereas in group A 25OHD2 increased enormously , 25OHD3 was suppressed possibly by substrate competition for hydroxylation in the liver and 1,25 ( OH ) 2D was halved . The suppression of 1,25 ( OH ) 2D may be an effect of raised 25OHD2 alone , or in combination with corticosteroid excess .
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Intervention_Pharmacological
vitamin D2 , calcium phosphate
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Intervention_Pharmacological
sodium fluoride
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Intervention_Pharmacological
prednisone
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Intervention_Pharmacological
Group A received prednisone plus 'triple-treatment ' ( vitamin D2 45000 iu twice weekly , sodium fluoride 50 mg and calcium phosphate 4.5 g daily ) , group B received only prednisone
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Intervention_Pharmacological
prednisone-
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Intervention_Pharmacological
triple-treatment
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Outcome_Physical
osteopenia
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Outcome_Physical
vitamin D metabolism
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Outcome_Physical
bone mineral content ( BMC )
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Outcome_Physical
vitamin D metabolism
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Outcome_Physical
BMC
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Outcome_Physical
Serum concentrations of 25OHD2 , 25OHD3 and 1,25 ( OH ) 2D
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Outcome_Physical
25OHD2
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Outcome_Physical
25OHD3
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Outcome_Physical
1,25 ( OH ) 2D
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Outcome_Physical
1,25 ( OH ) 2D
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Participant_Sample-size
Thirty-one