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document
Predictors of response to ziprasidone : results from a 6-week randomized double-blind , placebo-controlled trial for acute depressive mixed state . INTRODUCTION The present study is aimed at investigating possible predictors of response to ziprasidone in a sample of patients with mixed depressive state . METHODS 72 patients were randomized to either ziprasidone or placebo and treated prospectively for 6 weeks . The clinical response and remission were defined with various clinical variables including Montgomery Asberg Depression Rating Scale . Further outcome measures included predictors of remission and other clinical variables over time . RESULTS None of the variables under investigation were significantly associated with response or remission at 6 weeks ( all p-values > 0.003 , respectively ) . CONCLUSIONS Further investigations are warranted due to clear limitations , mostly small sample size and use of concomitant medications .
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Intervention_Pharmacological
ziprasidone
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
ziprasidone
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Intervention_Pharmacological
placebo
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Outcome_Mental
Montgomery Asberg Depression Rating Scale .
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Outcome_Physical
remission
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Outcome_Physical
response or remission
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Participant_Condition
acute depressive mixed state
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Participant_Condition
mixed depressive state
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Participant_Sample-size
72