30484
document
Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery . The goal of this study was to evaluate the efficacy of single- and multi-dose ( 5-day ) clindamycin therapy for the prevention of inflammatory complications in patients undergoing lower third molar surgical extraction with bone removal . Patients who qualified for the prospective , randomized , double-masked , placebo-controlled trial were randomly divided into three groups : ( 1 ) single dose of oral clindamycin administered preoperatively ( single-dose group ) ; ( 2 ) clindamycin administered preoperatively with continued therapy for 5 days ( 5-day group ) ; and ( 3 ) a placebo group . The following parameters were evaluated on the first , second and seventh days postsurgery : trismus , facial swelling , body temperature , lymphadenopathy , alveolar osteitis and subjective pain sensations . There were 86 patients ( 31 in the single-dose group , 28 in the 5-day group and 27 in the placebo group ) enrolled in the study . There were no statistically significant differences in postoperative inflammatory complications in patients during the first and second days postsurgery . A statistically significant variation in body temperature was reported on the seventh day . Analysis of the postoperative analgesic intake did not show statistically significant differences between examined groups . Clindamycin applied in a single preoperative dose of 600 mg with or without subsequent 5-day therapy does not demonstrate efficacy in prophylaxis for postoperative inflammatory complications after third molar surgery .
30485
Intervention_Pharmacological
clindamycin therapy
30486
Intervention_Pharmacological
clindamycin therapy
30487
Intervention_Control
placebo-controlled
30488
Intervention_Pharmacological
single dose of oral clindamycin administered preoperatively
30489
Intervention_Pharmacological
clindamycin administered preoperatively with continued therapy for 5 days
30490
Intervention_Control
placebo
30491
Intervention_Control
placebo
30492
Intervention_Pharmacological
Clindamycin
30493
Outcome_Other
trismus , facial swelling , body temperature , lymphadenopathy , alveolar osteitis and subjective pain sensations .
30494
Outcome_Physical
postoperative inflammatory complications
30495
Outcome_Physical
variation
30496
Outcome_Physical
body temperature
30497
Outcome_Physical
postoperative analgesic intake
30498
Outcome_Physical
efficacy