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document
The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis . Hypertension is associated with impaired fibrinolysis . Both angiotensin receptor blockers ( ARB ) and the DASH ( Dietary Approaches to Stop Hypertension ) diet effectively lower blood pressure in hypertensive patients . Some evidence suggests that treatment with ARBs could increase fibrinolysis , however , data is conflicting . The impact of the DASH diet on fibrinolytic parameters is not known . Fifty-five hypertensive participants ( 35 African-American , 20 white ) were randomly assigned to receive 8 weeks of either a control diet or the DASH diet . The diets did not differ in sodium content ( approximately 3 g/day ) . Within each diet , individuals were randomly assigned to receive losartan or placebo for 4 weeks in double-blind , cross-over fashion . Tissue plasminogen activator ( t-PA ) antigen , t-PA activity , plasminogen activator inhibitor-1 ( PAI-1 ) activity and plasma renin activity ( PRA ) were measured at the end of a 2-week run-in period on the control diet and after each treatment period . The DASH diet did not affect markers of fibrinolysis . Losartan significantly lowered t-PA antigen levels ( -1.8 ng/mL , P = 0.045 ) , but had no effect on t-PA or PAI-1 activities . This effect was more pronounced in whites ( -4.1 ng/mL ( P = 0.003 ) ) compared with African-Americans ( -0.3 ng/mL ( P = 0.7 ) , P-interaction = 0.03 ) . Results were not materially affected by adjustment for basline values or changes in blood pressure . This study demonstrates that losartan reduces t-PA antigen levels in white , but not African-American hypertensive individuals . In contrast , the DASH diet had no significant effect on markers of fibrinolysis in whites or African-Americans .
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Intervention_Pharmacological
angiotensin II receptor blockade
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Intervention_Pharmacological
DASH diet
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Intervention_Pharmacological
angiotensin receptor blockers ( ARB )
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Intervention_Pharmacological
DASH ( Dietary Approaches to Stop Hypertension ) diet
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Intervention_Other
control diet
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Intervention_Pharmacological
DASH diet
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Intervention_Pharmacological
losartan
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Intervention_Control
placebo
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Intervention_Other
diet
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Outcome_Physical
markers
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Outcome_Physical
blood pressure
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Outcome_Physical
fibrinolytic parameters
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Outcome_Physical
Tissue plasminogen activator ( t-PA ) antigen
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Outcome_Physical
t-PA activity
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Outcome_Physical
plasminogen activator inhibitor-1 ( PAI-1 ) activity
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Outcome_Physical
plasma renin activity ( PRA )
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Outcome_Physical
t-PA antigen levels
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Outcome_Physical
t-PA
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Outcome_Physical
PAI-1
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Outcome_Physical
blood pressure
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Outcome_Physical
t-PA antigen levels
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Outcome_Physical
markers of fibrinolysis
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Participant_Condition
hypertensive patients .
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Participant_Condition
white , but not African-American hypertensive individuals .