90508
document
Nimodipine pharmacotherapeutic adjuvant therapy for inpatient treatment of cocaine dependence . Recent preclinical studies suggest utility for voltage-sensitive calcium channel blockers ( VSCCBs ) in the treatment of cocaine addiction . The following double-blind placebo-controlled study examined the role of the VSCCB nimodipine in attenuating cocaine craving in 66 recently abstinent cocaine-dependent patients on an inpatient substance abuse treatment unit utilizing an intensive 12-step milieu-oriented psychosocial therapy . While the medication was well tolerated , the dose of nimodipine used in this study ( 90 mg q.d . ) was not superior to placebo in reducing background or cue-induced cocaine craving over the 3 weeks of the study . There was the suggestion that nimodipine might attenuate the severity of some cocaine-induced brain deficits , as detected by evaluation of smooth pursuit eye movement function . A rationale for evaluating higher doses of nimodipine for the treatment of cocaine addiction is presented . As nimodipine might have anticraving and mood-stabilizing properties and cardio- and neuroprotective properties in the face of cocaine intoxication and might possibly even reverse some cocaine-induced brain deficits , further investigation of the role of nimodipine ( and other VSCCBs ) in cocaine addiction appears an attractive avenue of future medication development .
90509
Intervention_Pharmacological
Nimodipine
90510
Intervention_Control
placebo-controlled
90511
Intervention_Pharmacological
nimodipine
90512
Intervention_Pharmacological
nimodipine
90513
Intervention_Control
placebo
90514
Intervention_Pharmacological
nimodipine
90515
Intervention_Pharmacological
nimodipine
90516
Intervention_Pharmacological
nimodipine
90517
Intervention_Pharmacological
nimodipine
90518
Outcome_Physical
smooth pursuit eye movement function .
90519
Participant_Condition
inpatient treatment of cocaine dependence .
90520
Participant_Condition
cocaine addiction .