11242
document
Investigation of the effect of FK506 ( tacrolimus ) and cyclosporin on gingival overgrowth following paediatric liver transplantation . INTRODUCTION Gingival overgrowth associated with immunosuppression following liver transplantation is a commonly recognized clinical problem . The aims of this study were to determine the incidence of gingival overgrowth in a group of children post liver transplantation and to compare gingival overgrowth in children receiving FK506 with those receiving cyclosporin . METHODS Seventy-nine children ( aged 15-196 months ) undergoing liver transplantation at Birmingham Children 's Hospital between October 1998 and October 2000 were studied . Gingival overgrowth was assessed in a blinded fashion and scored in a previously validated manner . Gingival overgrowth scores of the patients on each immunosuppressant drug were then compared . RESULTS Fifty-two patients were treated with cyclosporin and 27 treated with tacrolimus . Eighteen children were also receiving nifedipine ( also known to cause gingival overgrowth ) and were considered separately . Of the 41 children receiving cyclosporin alone , 26 exhibited gingival overgrowth compared to zero of 20 patients receiving tacrolimus alone . Those children treated with immunosuppression plus nifedipine developed gingival overgrowth , however , this was much less marked in the tacrolimus group . CONCLUSION Tacrolimus , unlike cyclosporin , is not associated with gingival overgrowth when used for immunosuppression following liver transplantation in children , and may be the drug of choice for children .
11243
Intervention_Pharmacological
FK506 ( tacrolimus )
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Intervention_Pharmacological
cyclosporin
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Intervention_Pharmacological
FK506
11246
Intervention_Pharmacological
cyclosporin
11247
Intervention_Pharmacological
cyclosporin
11248
Intervention_Pharmacological
tacrolimus
11249
Intervention_Pharmacological
nifedipine
11250
Intervention_Pharmacological
cyclosporin
11251
Intervention_Pharmacological
tacrolimus
11252
Intervention_Pharmacological
tacrolimus
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Intervention_Pharmacological
Tacrolimus
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Intervention_Pharmacological
cyclosporin
11255
Outcome_Physical
Gingival overgrowth
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Outcome_Physical
Gingival overgrowth
11257
Outcome_Physical
gingival overgrowth
11258
Outcome_Physical
gingival overgrowth
11259
Outcome_Physical
gingival overgrowth
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Outcome_Physical
gingival overgrowth
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Participant_Age
paediatric
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Participant_Condition
liver transplantation .
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Participant_Age
children
11264
Participant_Condition
gingival overgrowth
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Participant_Age
children
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Participant_Sample-size
Seventy-nine
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Participant_Age
children ( aged 15-196 months )
11268
Participant_Condition
Fifty-two patients
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Participant_Age
children
11270
Participant_Sample-size
41
11271
Participant_Age
children
11272
Participant_Sample-size
26
11273
Participant_Condition
gingival overgrowth
11274
Participant_Sample-size
zero of 20 patients
11275
Participant_Age
children
11276
Participant_Age
children