90642
document
Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy . OBJECTIVE To evaluate the effectiveness of early administration of intravenous Magnesium sulfate ( i.v . MgSO4 ) in children with acute severe asthma not responding to conventional therapy . DESIGN Randomized double-blind , placebo-controlled trial . SETTING Pediatric emergency service of a large teaching hospital . SUBJECTS 47 children aged between 1-12 years with acute severe asthma showing inadequate or poor response to 3 doses of nebulized salbutamol given at an interval of 20 min each . INTERVENTION The MgSO4 group received 0.2 ml/kg of 50 % MgSO4 as intravenous ( i.v . ) infusion over 35 minutes and the placebo group received normal saline infusion in the same dose and at the same rate . MgSO4 solution and normal saline were coded and dispensed in identical containers . Decoding was done at the completion of the study . All the patients received oxygen , nebulized salbutamol , i.v . aminophylline and corticosteroids . RESULTS MgSO4 group showed early and significant improvement as compared to placebo group in PEFR and SaO2 at 30 min and 1 , 2 , 3 and 7 hours after stopping the infusion ( p ranging from < 0.05 to < 0.01 ) . The clinical asthma score also showed significant improvement in the MgSO4 group 1 , 2 , 3 and 11 hours after stopping the infusion ( p < 0.01 ) . CONCLUSION Addition of MgSO4 to conventional therapy helps in achieving earlier improvement in clinical signs and symptoms of asthma and PEFR in patients not responding to conventional therapy alone .
90643
Intervention_Pharmacological
Intravenous magnesium sulfate
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Intervention_Physical
conventional therapy
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Intervention_Pharmacological
intravenous Magnesium sulfate ( i.v . MgSO4 )
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Intervention_Physical
conventional therapy
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
nebulized salbutamol
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Intervention_Pharmacological
MgSO4
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Intervention_Pharmacological
received 0.2 ml/kg of 50 % MgSO4 as intravenous ( i.v . ) infusion
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Intervention_Control
placebo
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Intervention_Pharmacological
normal saline infusion
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Intervention_Pharmacological
MgSO4 solution
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Intervention_Pharmacological
normal saline
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Intervention_Pharmacological
oxygen , nebulized salbutamol , i.v . aminophylline
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Intervention_Pharmacological
corticosteroids .
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Intervention_Pharmacological
MgSO4
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Intervention_Control
placebo
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Intervention_Pharmacological
MgSO4
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Intervention_Pharmacological
MgSO4
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Intervention_Physical
conventional therapy
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Outcome_Physical
acute severe asthma
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Outcome_Other
inadequate or poor response
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Outcome_Other
early and significant improvement
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Outcome_Physical
PEFR
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Outcome_Physical
SaO2
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Outcome_Physical
clinical asthma score
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Outcome_Physical
improvement in clinical signs
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Outcome_Physical
symptoms of asthma and PEFR
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Participant_Condition
acute severe asthma not responding to conventional therapy .
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Participant_Age
children
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Participant_Condition
acute severe asthma not responding to conventional therapy
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Participant_Sample-size
47 children
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Participant_Age
aged between 1-12 years