71482
document
Comparison of the neuroprotective effects and recovery profiles of isoflurane , sevoflurane and desflurane as neurosurgical pre-conditioning on ischemia/reperfusion cerebral injury . BACKGROUND There are a few reports regarding the comparison of these anesthetic agents , but previous studies mainly focus on the veterinary anesthesiology . Less attention has been focused comparing the effectiveness of these inhalational anesthetic agents in neurosurgery . This lack of interest is regretful particularly considering the fact that anesthetics during neurosurgery are an issue of extreme sensitivity and subtlety , where the cerebral oxygenation process plays a significant role in the neuroprotective mechanisms . OBJECTIVE The purpose of this retrospective study is to contribute to the existing knowledge of the comparative studies of the volatile anesthetic agents such as isoflurane , sevoflurane and desflurane by evaluating the maintenance and emergence characteristics after volatile anesthetics-induced preconditioning with isoflurane , sevoflurane or desflurane for inpatient ischemia/reperfusion cerebral injury during cerebral or neural surgeries . METHODS The aim was to investigate their neuroprotective mechanisms and effects by analyzing and comparing the superiority of each agent in a Chinese patient population , in terms of faster emergence , and early and intermediate recovery . The intraoperative haemodynamic profiles and postoperative adverse effects of these three agents were also systematically analyzed . RESULTS We found that sevoflurane , when compared with isoflurane and desflurane , provided anesthesia with similar hemodynamic stability but allowed for a smoother , more rapid emergence and better quality of induction and recovery to surgical patients under clinical conditions , particularly to those who were experiencing substantial cerebral vasodilation . CONCLUSION Sevoflurane offers several advantages , including a relative lack of airway irritation , a more rapid onset and recovery , and greater hemodynamic stability than other potent inhaled agents . These properties would appear to afford sevoflurane significant clinical potential .
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Intervention_Pharmacological
isoflurane
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Intervention_Pharmacological
sevoflurane
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Intervention_Pharmacological
desflurane
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Intervention_Pharmacological
isoflurane
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Intervention_Pharmacological
sevoflurane
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Intervention_Pharmacological
desflurane
71489
Intervention_Pharmacological
isoflurane
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Intervention_Pharmacological
sevoflurane
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Intervention_Pharmacological
desflurane
71492
Intervention_Pharmacological
sevoflurane
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Intervention_Pharmacological
isoflurane
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Intervention_Pharmacological
desflurane
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Intervention_Pharmacological
Sevoflurane
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Outcome_Adverse-effects
neuroprotective effects
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Outcome_Other
recovery profiles
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Outcome_Adverse-effects
effects
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Outcome_Other
intraoperative haemodynamic profiles
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Outcome_Adverse-effects
postoperative adverse effects
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Outcome_Other
emergence
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Outcome_Other
quality of induction and recovery
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Outcome_Physical
airway irritation
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Outcome_Other
onset and recovery
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Outcome_Physical
hemodynamic stability
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Participant_Condition
ischemia/reperfusion cerebral injury
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Participant_Condition
neurosurgery
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Participant_Condition
ischemia/reperfusion cerebral injury
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Participant_Condition
substantial cerebral vasodilation