86539
document
Placebo-controlled acute dosage naltrexone study in young autistic children . In a double-blind , placebo-controlled crossover trial 23 autistic children were treated with a single 40-mg dose of the opiate antagonist naltrexone . Drug effects were monitored by detailed playroom observations , actometers , and parents ' checklist ratings ( Aberrant Behavior Checklist , social items and target behaviors ) . Naltrexone treatment failed to produce significant changes in social behavior , but it did reduce irritability and target scores on behavior checklists . The playroom data indicated that naltrexone significantly affected indices of activity and attention .
86540
Intervention_Control
Placebo-controlled
86541
Intervention_Pharmacological
naltrexone
86542
Intervention_Control
placebo-controlled
86543
Intervention_Pharmacological
naltrexone
86544
Intervention_Pharmacological
Naltrexone
86545
Intervention_Pharmacological
naltrexone
86546
Outcome_Mental
( Aberrant Behavior Checklist , social items and target behaviors ) .
86547
Outcome_Mental
significant changes
86548
Outcome_Mental
social behavior
86549
Outcome_Mental
reduce irritability and target scores on behavior checklists .
86550
Outcome_Mental
activity and attention
86551
Participant_Condition
young autistic children .
86552
Participant_Age
23 autistic children