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document
Management of unstable angina at rest by verapamil . A double-blind cross-over study in coronary care unit . A therapeutic trial with verapamil , a calcium-antagonist drug , was performed in 12 patients admitted to our coronary care unit because of frequent daily attacks of angina at rest attributed to coronary vasospasm . After a 48-hour run-in period , oral verapamil 480 mg/day and placebo were administered alternately during 4 randomised 48-hour periods . Transient ischaemic attacks with ST segment elevation or depression , with or without pain , were documented by continuous electrocardiographic monitoring . The number of attacks during the run-in and 2 placebo periods were 128 , 123 , and 130 , respectively , and 31 and 23 during the 2 treatment periods ( P less than 0.006 and P less than 0.003 ) . This drug therefore appears to be effective in the management of patients with frequent attacks of angina at rest .
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Intervention_Pharmacological
verapamil
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Intervention_Pharmacological
verapamil
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Intervention_Pharmacological
calcium-antagonist drug
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Intervention_Pharmacological
oral verapamil 480 mg/day
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Intervention_Control
placebo
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Intervention_Control
placebo
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Outcome_Physical
Transient ischaemic attacks with ST segment elevation or depression , with or without pain
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Outcome_Other
continuous electrocardiographic monitoring
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Outcome_Physical
number of attacks
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Outcome_Physical
attacks of angina at rest
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Participant_Condition
unstable angina
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Participant_Sample-size
12 patients
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Participant_Condition
angina
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Participant_Condition
coronary vasospasm
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Participant_Condition
angina