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document
The role of routinely given hyoscine-N-butylbromide in colonoscopy : a double-blind , randomized , placebo-controlled , clinical trial . OBJECTIVE Hyoscine-N-butylbromide ( HBB ) has been proposed to ease colonoscopy and improve mucosal visualization , yet the results from previous studies are conflicting . In our prospective , double-blind , placebo-controlled , randomized study we aimed at evaluating whether routine administration of HBB , before and during colonoscopy , ease the procedure or increase the detection rate for polyps . MATERIAL AND METHODS One hundred fifty outpatients scheduled for an elective colonoscopy were randomized to receive intravenous injections of either 10 mg hyoscine-N-butylbromide or saline before insertion and at cecum . Patient tolerance and technical ease of colonoscopy were evaluated by visual analogue scale ( VAS ) . Procedure times were recorded . Number of detected polyps per patient was evaluated as well . Heart rate was monitored with a pulse oximetry . RESULTS HBB did not improve patient tolerance or technically ease the procedure as evaluated by VAS . However , HBB led to faster ileal intubation ( 1.5 vs 2.0 min , p < 0.001 ) and shorter total procedure time ( 22.0 vs 24.0 min , p = 0.03 ) . Patients who received HBB also needed less often external abdominal pressure ( 48.6 vs 66.7 % , p = 0.03 ) . HBB did not improve polyp detection rate ( 0.89 vs 0.91 , p = 0.90 ) . HBB induced a significant rise in heart rate ( p < 0.001 ) and more often tachycardia ( 17.6 vs 0 % , p < 0.001 ) . CONCLUSIONS Routine administration of HBB before and during colonoscopy yields only limited improvement in the technical performance of the examination compromised by high incidence of tachycardia .
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Intervention_Pharmacological
hyoscine-N-butylbromide
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
Hyoscine-N-butylbromide ( HBB )
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
HBB
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Intervention_Pharmacological
hyoscine-N-butylbromide or saline before
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Intervention_Pharmacological
HBB
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Intervention_Pharmacological
HBB
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Intervention_Pharmacological
HBB
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Intervention_Pharmacological
HBB
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Intervention_Pharmacological
HBB
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Intervention_Pharmacological
HBB
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Outcome_Other
ease the procedure
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Outcome_Other
increase the detection rate for polyps
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Outcome_Other
Patient tolerance
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Outcome_Other
technical ease of colonoscopy
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Outcome_Other
Procedure times
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Outcome_Other
Number of detected polyps per patient
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Outcome_Physical
Heart rate
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Outcome_Other
patient tolerance
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Outcome_Other
technically ease the procedure
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Outcome_Other
total procedure time
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Outcome_Physical
external abdominal pressure
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Outcome_Other
polyp detection rate
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Outcome_Physical
heart rate
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Outcome_Physical
tachycardia
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Outcome_Other
technical performance of the examination
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Outcome_Physical
tachycardia .
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Participant_Condition
colonoscopy :
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Participant_Sample-size
One hundred fifty
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Participant_Condition
elective colonoscopy