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document
A controlled study comparing patients with and without polycystic ovaries undergoing in-vitro fertilization . The outcome of in-vitro fertilization and embryo transfer ( IVF-ET ) was compared in 76 patients with polycystic ovaries ( PCO ) diagnosed on pre-treatment ultrasound scan , and 76 control patients who had normal ovaries and were matched for age , cause of infertility and stimulation regimen . Despite receiving significantly less human menopausal gonadotrophin ( HMG ) , patients with PCO , as compared with controls , had significantly higher serum oestradiol levels on the day of human chorionic gonadotrophin administration ( 5940 +/- 255 versus 4370 +/- 240 pmol/l , P < 0.001 ) , developed more follicles ( 14.9 +/- 0.7 versus 9.8 +/- 0.6 , P < 0.001 ) and produced more oocytes ( 9.3 +/- 0.6 versus 6.8 +/- 0.5 , P = 0.003 ) . However , fertilization rates were reduced in the PCO patients ( 52.8 +/- 3.4 % versus 66.1 +/- 3.4 % , P = 0.007 ) . There was no significant difference in cleavage rates . The pregnancy rate/embryo transfer was 25.4 % in the PCO group and 23.0 % in the group with normal ovaries . There were three high order multiple pregnancies in the PCO group compared with none in the group with normal ovaries . Of the PCO patients , 10.5 % developed moderate/severe ovarian hyperstimulation syndrome ( OHSS ) compared with none of the controls ( P = 0.006 ) . Patients with and without PCO undergoing IVF have comparable pregnancy and livebirth rates . However , it is important to diagnose PCO before ovarian stimulation is initiated as these patients are more likely to develop moderate or severe OHSS following IVF-ET .
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Intervention_Physical
in-vitro fertilization and embryo transfer ( IVF-ET )
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Intervention_Physical
human menopausal gonadotrophin ( HMG )
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Intervention_Physical
chorionic gonadotrophin
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Outcome_Physical
in-vitro fertilization .
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Outcome_Physical
serum oestradiol levels
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Outcome_Physical
follicles
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Outcome_Physical
oocytes
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Outcome_Physical
fertilization rates
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Outcome_Physical
cleavage rates .
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Outcome_Physical
pregnancy rate/embryo transfer
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Outcome_Physical
ovarian hyperstimulation syndrome ( OHSS )
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Outcome_Physical
pregnancy and livebirth rates .
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Participant_Condition
polycystic ovaries
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Participant_Sample-size
76
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Participant_Condition
polycystic ovaries
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Participant_Sample-size
76
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Participant_Condition
control
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Participant_Condition
PCO
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Participant_Condition
PCO
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Participant_Condition
group with normal ovaries
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Participant_Condition
PCO