82354
document
The effect of cisapride on delayed colonic transit time in patients with idiopathic Parkinson 's disease . Disorders of autonomic regulation are common in patients with Parkinson 's disease ( PD ) . Patients most frequently complain of dysphagia and therapy resistant constipation , as far as the gastrointestinal tract is concerned . These symptoms have to be attributed to a neuronal degeneration . In a pilot study we therefore investigated the effect of stimulation of the myenteric plexus by cisapride . 11 women and 13 men were examined , the average age was 67.3 years , the Webster rating 17 points . In 2 out of 24 patients , colonic transit was prolonged up to the limit , both with and without therapy . The other 22 patients showed an acceleration in transit on response to cisapride . On average the colonic transit of 130 hours was reduced to 79 hours . This objective improvement was associated with a subjective improvement . Central side effects or a worsening of Parkinsonian symptoms were not found . We conclude that cisapride is effective in the treatment of constipation in idiopathic PD .
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Intervention_Pharmacological
cisapride
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Intervention_Pharmacological
cisapride .
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Intervention_Pharmacological
cisapride .
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Intervention_Pharmacological
cisapride
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Outcome_Physical
colonic transit time
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Outcome_Physical
colonic transit
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Outcome_Physical
acceleration in transit
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Outcome_Physical
colonic transit
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Outcome_Physical
worsening of Parkinsonian symptoms
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Participant_Condition
idiopathic Parkinson 's disease
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Participant_Condition
Disorders of autonomic regulation
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Participant_Condition
Parkinson 's disease
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Participant_Condition
PD
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Participant_Sample-size
11
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Participant_Sex
women
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Participant_Sample-size
13
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Participant_Sex
men
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Participant_Age
67.3
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Participant_Condition
constipation
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Participant_Condition
idiopathic PD