74190
document
Comparative efficacy of oral erythromycin versus oral tetracycline in the treatment of acne vulgaris . A double-blind study . The efficacy of erythromycin base ( E-Mycin tablets , 333 mg ) and the efficacy of tetracycline hydrochloride ( Panmycin tablets ) were compared in this double-blind , randomized study . Two hundred patients with moderate to moderately severe acne vulgaris were randomly assigned to the study . One hundred patients received 1 gm of erythromycin base by mouth per day for 4 weeks , followed by 333 mg/day for 8 weeks , plus placebo for tetracycline . The second group of patients received 1 gm of tetracycline by mouth per day for 4 weeks , followed by 500 mg/day for 8 weeks , plus placebo for erythromycin . Both drugs reduced acne severity to the same extent . Pustules , papules , and open comedo counts decreased significantly over the 12-week period . Seventy-seven percent of the erythromycin-treated patients and 89 % of the tetracycline-treated patients stated that their acne was markedly improved or improved by week 12 . Most of the side effects in patients treated with erythromycin were gastrointestinal symptoms . Among the side effects in patients treated with tetracycline were Candida vaginitis in one patient and pseudotumor cerebri in one patient .
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Intervention_Pharmacological
oral erythromycin
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Intervention_Pharmacological
oral tetracycline
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Intervention_Pharmacological
erythromycin base
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Intervention_Pharmacological
tetracycline hydrochloride
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Intervention_Pharmacological
1 gm of erythromycin base
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Intervention_Control
placebo
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Intervention_Pharmacological
tetracycline
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Intervention_Pharmacological
tetracycline
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Intervention_Control
placebo
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Intervention_Pharmacological
erythromycin
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Outcome_Physical
acne vulgaris .
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Outcome_Other
efficacy
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Outcome_Physical
erythromycin base ( E-Mycin tablets , 333 mg )
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Outcome_Physical
efficacy
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Outcome_Physical
tetracycline hydrochloride
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Outcome_Physical
acne severity
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Outcome_Physical
Pustules , papules , and open comedo counts
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Outcome_Physical
acne
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Outcome_Adverse-effects
gastrointestinal symptoms .
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Outcome_Adverse-effects
Candida vaginitis
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Outcome_Adverse-effects
pseudotumor cerebri
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Participant_Sample-size
Two hundred patients
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Participant_Condition
moderate to moderately severe acne vulgaris