18990
document
The relationship of changes in EORTC QLQ-C30 scores to ratings on the Subjective Significance Questionnaire in men with localized prostate cancer . PURPOSE To examine the relationship between changes in health-related quality-of-life ( HRQOL ) on the EORTC Quality of Life Questionnaire ( QLQ-C30 ) , and patients ' perceptions of HRQOL changes as measured by the Subjective Significance Questionnaire ( SSQ ) . PATIENTS AND METHODS A total of 101 patients completed the QLQ-C30 on weeks 1 , 4 and 7 of radical external-beam radiation therapy ( RT ) for localized cancer of the prostate . Patients rated their change in physical functioning , emotional functioning , social functioning , and overall/global quality of life ( QOL ) by completing a seven-category SSQ at weeks 4 and 7 . The association between changes in the QLQ-C30 change and the corresponding SSQ ratings were determined by calculation of mean change scores for each SSQ category and by Spearman rank correlation coefficient analysis . RESULTS Patients ' completion of the QLQ-C30 and SSQ exceeded 95 % . Statistically significant changes in fatigue , pain , appetite , diarrhea , and global QOL scores were detected during RT . For patients reporting 'a little ' change in global QOL on the SSQ , absolute mean QLQ-C30 change scores ranged between 0 to 15 points with 12/16 mean change scores between 2.5 and 8.5 points . In the entire study sample , correlations between SSQ patient ratings and QLQ-C30 change scores were lower than previously reported , ranging between 0.15 and 0.24 for the four different domains , but were higher when QOL scores producing ceiling effects were omitted . CONCLUSION The SSQ and QLQ-C30 may measure related concepts that could assist in the interpretation of changes in scores and in the calibration of the QLQ-C30 . However , the nature of this relationship could not be elucidated in this data set because of a lack of variance in HRQOL scores in the study sample . Further investigation should be carried out in study samples with sufficient variance to allow more robust conclusions .
18991
Intervention_Educational
Questionnaire
18992
Intervention_Educational
EORTC Quality of Life Questionnaire ( QLQ-C30
18993
Intervention_Educational
Subjective Significance Questionnaire ( SSQ )
18994
Intervention_Educational
QLQ-C30
18995
Intervention_Physical
external-beam radiation therapy ( RT )
18996
Intervention_Educational
SSQ
18997
Intervention_Educational
SSQ
18998
Intervention_Educational
SSQ
18999
Intervention_Educational
SSQ
19000
Intervention_Educational
SSQ
19001
Intervention_Educational
SSQ
19002
Intervention_Educational
SSQ
19003
Intervention_Psychological
QLQ-C30
19004
Intervention_Educational
QLQ-C30
19005
Outcome_Mental
Subjective Significance Questionnaire
19006
Outcome_Mental
health-related quality-of-life ( HRQOL )
19007
Outcome_Mental
EORTC Quality of Life Questionnaire ( QLQ-C30 )
19008
Outcome_Mental
Subjective Significance Questionnaire ( SSQ )
19009
Outcome_Physical
physical functioning
19010
Outcome_Mental
emotional functioning
19011
Outcome_Mental
social functioning
19012
Outcome_Mental
overall/global quality of life ( QOL )
19013
Outcome_Other
seven-category SSQ
19014
Outcome_Physical
fatigue
19015
Outcome_Pain
pain
19016
Outcome_Physical
appetite
19017
Outcome_Physical
diarrhea
19018
Outcome_Mental
global QOL scores
19019
Outcome_Mental
global QOL
19020
Outcome_Mental
SSQ
19021
Outcome_Mental
QLQ-C30 change scores
19022
Outcome_Mental
QOL scores
19023
Participant_Condition
men with localized prostate cancer .
19024
Participant_Sample-size
101