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document
[ Late cardiac toxicity in Hodgkin 's disease . A study with pulsed Doppler echocardiography ] . 49 patients ( 22 women , 27 men , mean age 43.7 [ 21-65 ] years ) with Hodgkin 's disease were examined by Doppler echocardiography a median of 5.37 ( 2-10 ) years after the end of chemotherapy ( given according to the COPP/ABVD scheme , with or without mediastinal irradiation ) for possible chronic changes in myocardium , pericardium or cardiac valves , as well as for any haemodynamic sequelae . Maximal and integrated early ( E , Ei ) and late ( A , Ai ) diastolic flow velocities and their ratio ( E/A , Ei/Ai ) were measured by pulsed Doppler over the mitral and tricuspid valves . Although on two-dimensional echo 21 patients ( 42.9 % ) were found to have valvar thickening , 19 ( 38.8 % ) pericardial thickening and 9 ( 18.4 % ) a reduced fibre shortening fraction , the Doppler indices were statistically not significantly different from those in 25 controls with normal hearts . These echocardiographic data of functional and morphological parameters indicate that there was no effect on various measurements of diastolic function after chemotherapy with or without mediastinal radiation . In successfully treated patients with Hodgkin 's disease the described changes are of minor significance .
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Intervention_Physical
pulsed Doppler echocardiography
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Intervention_Physical
Doppler echocardiography
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Intervention_Physical
mediastinal irradiation
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Intervention_Physical
pulsed Doppler
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Outcome_Physical
cardiac toxicity
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Outcome_Physical
chronic changes in myocardium , pericardium or cardiac valves
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Outcome_Physical
haemodynamic sequelae
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Outcome_Other
Maximal and integrated early
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Outcome_Physical
( E , Ei )
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Outcome_Other
late ( A , Ai ) diastolic flow velocities and their ratio
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Outcome_Physical
( E/A , Ei/Ai )
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Outcome_Physical
valvar thickening
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Outcome_Physical
pericardial thickening
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Outcome_Physical
reduced fibre shortening fraction , the
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Outcome_Other
Doppler indices
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Outcome_Physical
functional and morphological parameters
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Outcome_Physical
measurements of diastolic function
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Participant_Sample-size
49
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Participant_Sample-size
22
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Participant_Sex
women
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Participant_Sample-size
27
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Participant_Sex
men
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Participant_Age
43.7
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Participant_Age
21-65
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Participant_Condition
Hodgkin 's disease
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Participant_Condition
Hodgkin 's disease