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document
Randomized evaluation of octreotide vs prochlorperazine for ED treatment of migraine headache . UNLABELLED Patients with headaches account for approximately 2 % of all ED visits , with migraines being the most common defined primary headache syndrome . Our goals were to evaluate the efficacy of intravenous octreotide ( OC ) for the treatment of migraines , when compared to standard therapy with prochlorperazine . METHODS The study was conducted as a double-blinded , randomized controlled trial . Each subject received either 100 microg of octreotide or 10 mg of prochlorperazine intravenously for a 2-minute period . RESULTS Comparison of the change in median visual analog scale scores for 60 minutes demonstrated that octreotide was less effective at reducing pain ( P = .03 ) and producing clinical success ( P < .01 ) . Restlessness consistent with akathisia was noted by 35 % of the PC group and 8 % of the OC group ( P < .01 ) . At 60 minutes , rescue medication was required by 48 % of the patients in the OC group , whereas 10 % of the PC group required such therapy ( P < .01 ) . All 44 patients were contacted for follow-up at 48 to 72 hours after enrollment . At that time , 10 % of the prochlorperazine and 25 % of the octreotide patients had experienced some headache recurrence ( P = .1 ) . CONCLUSION Prochlorperazine was statistically superior to octreotide in clinical success rate and decrease in pain in migraine patients but caused more restlessness and sedation .
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Intervention_Pharmacological
octreotide
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Intervention_Pharmacological
prochlorperazine
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Intervention_Pharmacological
octreotide ( OC )
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Intervention_Pharmacological
prochlorperazine .
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Intervention_Pharmacological
octreotide
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Intervention_Pharmacological
prochlorperazine
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Intervention_Pharmacological
octreotide
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Intervention_Pharmacological
prochlorperazine
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Intervention_Pharmacological
octreotide
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Outcome_Physical
migraine headache
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Outcome_Physical
median visual analog scale scores
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Outcome_Pain
pain
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Outcome_Physical
Restlessness consistent with akathisia
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Outcome_Physical
rescue medication
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Outcome_Physical
headache recurrence
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Outcome_Other
clinical success rate
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Outcome_Pain
pain
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Outcome_Physical
restlessness
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Outcome_Pain
sedation