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document
Combined action of enalapril or timolol with hydrochlorothiazide plus amiloride in hypertension . 59 mild to moderate hypertensives were treated for four weeks with 50 mg hydrochlorothiazide plus 5 mg of amiloride , then concomitantly with these diuretics with either enalapril ( 10-20 mg ) or timolol ( 10-20 mg ) in two parallel treatment groups for an additional 12 weeks in an open study . Addition of these drugs lowered the blood pressure by 25 +/- 3/16 +/- 2 mm Hg and 15 +/- 3/14 +/- 1 mm Hg , respectively . The difference of the reduction of the systolic blood pressure between enalapril and timolol group at the end of the combined treatment was statistically significant ( p less than 0.01 ) . The mean serum potassium was elevated by 0.3 mmol/l after addition of enalapril to the diuretic treatment , but none of the patients developed hyperkalaemia . No adverse effects on other routine laboratory values were observed . Both drug combinations can be considered efficient , well tolerated and safe in the treatment of mild to moderate hypertension .
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Intervention_Pharmacological
enalapril
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Intervention_Pharmacological
timolol
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Intervention_Pharmacological
hydrochlorothiazide plus amiloride
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Intervention_Pharmacological
hydrochlorothiazide
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Intervention_Pharmacological
amiloride
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Intervention_Pharmacological
enalapril
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Intervention_Pharmacological
timolol
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Outcome_Physical
blood pressure
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Outcome_Physical
systolic blood pressure
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Outcome_Physical
mean serum potassium
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Outcome_Physical
hyperkalaemia
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Outcome_Adverse-effects
adverse effects
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Outcome_Other
tolerated and safe
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Participant_Condition
hypertension
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Participant_Sample-size
59
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Participant_Condition
mild to moderate hypertensives