58172
document
Pretreatment and co-administration of oral anti-diabetic agent with clomiphene citrate or rFSH for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome . AIM The objective of this study was to explore the result of pretreatment and concomitant use of metformin with clomiphene citrate ( CC ) and rFSH for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome ( PCOS ) . MATERIAL AND METHODS This randomized controlled trial was done in the Dhaka Medical College and Hospital and the Infertility Care and Research Centre , Dhaka , Bangladesh . A total of 165 infertile patients with CC-resistant PCOS who attended for treatment were the target population for this study . Patients were divided into three groups : groups A and B were given metformin and group C was the control . Along with metformin , group A received CC and group B received rFSH . Group C was treated with only rFSH . Metformin was given 1500 mg daily for 4 weeks . Afterwards CC or rFSH were added for induction of ovulation along with metformin . Six ovulatory cycles were assessed . Treatment was terminated when there was no response with maximum dose of CC and rFSH or after six ovulatory cycles without pregnancy or after achieving pregnancy . A P-value of < 0.5 was considered as significant . RESULTS Ovulation ( 89.09 % ) and pregnancy ( 54.55 % ) rates were higher in group B. Ovulation ( 74.55 % ) and pregnancy ( 29.09 % ) rates were also satisfactory in group C but a dose of rFSH requirement was significantly higher ( P = 0.000 ) . In group A , both ovulation and pregnancy rate were much lower than the other two groups ( 27.27 % and 12.73 % , respectively ) . CONCLUSIONS Use of metformin increases the response of ovulation-inducing agents and can be used safely in PCOS .
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Intervention_Pharmacological
oral anti-diabetic agent
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Intervention_Pharmacological
clomiphene citrate
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Intervention_Pharmacological
rFSH
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Intervention_Pharmacological
metformin
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Intervention_Pharmacological
clomiphene citrate ( CC )
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Intervention_Pharmacological
rFSH
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Intervention_Pharmacological
metformin
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Intervention_Control
control .
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Intervention_Pharmacological
metformin
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Intervention_Pharmacological
CC
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Intervention_Pharmacological
rFSH .
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Intervention_Pharmacological
rFSH . Metformin
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Intervention_Pharmacological
CC
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Intervention_Pharmacological
rFSH
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Intervention_Pharmacological
CC
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Intervention_Pharmacological
rFSH
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Intervention_Pharmacological
rFSH
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Outcome_Physical
pregnancy