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document
Oral sildenafil to control pulmonary hypertension after congenital heart surgery . This study investigates the role of oral sildenafil in decreasing pulmonary pressure after congenital heart surgery . Between September 2002 and September 2004 , among a group of postoperative children with large septal defects , moderate to severe pulmonary hypertension [ pulmonary artery ( PA ) to aortic ( Ao ) pressure ratio of 0.76 +/- 0.17 ] and systemic desaturation ( Ao Sat = 0.89 +/- 0.11 ) , oral sildenafil ( 0.3 mg x kg ( -1 ) , every 3 hours ) was administered for a period of 24-48 hours ( sildenafil group ) . These patients were compared to a group of 22 children with similar pathologies who did not receive sildenafil ( control group ) . Postoperative PA pressure ( 28.61 +/- 7.80 vs 39.40 +/- 10.80 mm Hg ) and PA/Ao pressure ( 0.28 +/- 0.08 vs 0.41 +/- 0.11 ) were significantly lower in the sildenafil group ( p = 0.001 and 0.001 respectively ) . Pulmonary hypertensive crisis was detected in 4 patients in the control group , but none in the sildenafil group ( p = 0.02 ) . There was no significant rise in PA pressure following discontinuation of the drug ( 26.30 +/- 6.66 vs 28.49 +/- 10.93 mm Hg , p = 0.366 ) . No significant complications were noticed regarding sildenafil use . Low doses of oral sildenafil appear to be effective and safe to control postoperative PA pressure in children . Absence of rebound pulmonary hypertension , availability , and low cost of the drug are considered as its major advantages .
30303
Intervention_Pharmacological
Oral sildenafil
30304
Intervention_Pharmacological
sildenafil
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Intervention_Surgical
congenital heart surgery .
30306
Intervention_Pharmacological
oral sildenafil
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Intervention_Pharmacological
sildenafil
30308
Intervention_Pharmacological
sildenafil
30309
Intervention_Pharmacological
sildenafil
30310
Intervention_Pharmacological
sildenafil
30311
Intervention_Pharmacological
sildenafil
30312
Intervention_Pharmacological
sildenafil
30313
Outcome_Physical
pulmonary hypertension
30314
Outcome_Physical
pulmonary pressure
30315
Outcome_Physical
Postoperative PA pressure
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Outcome_Physical
PA/Ao pressure
30317
Outcome_Physical
Pulmonary hypertensive crisis
30318
Outcome_Physical
pulmonary hypertension
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Participant_Condition
after congenital heart surgery .
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Participant_Condition
after congenital heart surgery . Between September 2002 and September 2004 , among a group of postoperative children with large septal defects , moderate to severe pulmonary hypertension [ pulmonary artery ( PA ) to aortic ( Ao ) pressure ratio of 0.76 +/- 0.17 ] and systemic desaturation ( Ao Sat = 0.89 +/- 0.11 ) , oral sildenafil ( 0.3 mg x kg ( -1 ) , every 3 hours ) was administered for a period of 24-48 hours ( sildenafil group ) .
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Participant_Condition
patients
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Participant_Sample-size
22 children with similar pathologies who did not receive sildenafil ( control group ) .