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document
[ Effect of dopexamine in splanchnic perfusion during surgery of the abdominal aorta ] . Abdominal aortic surgery has significant effects on cardiac and splanchnic perfusion . The purpose of this study was to examine the effects of dopexamine , an inodilator drug , on hemodynamic and splanchnic perfusion with measurement of gastric intramucosal pH , by the method of gastric tonometry , during abdominal aneurysm resection . Twenty-five patients undergoing excision of an aortic abdominal aneurysm were randomly divided into two groups . During aortic cross-clamping Group II patients received dopexamine infusion , at a dose of 1 microgram/kg/m , and at a dose of 0.5 micrograms/kg/m from declamping to the end of the surgery . Whereas Group I patients did not receive a dopexamine infusion . During aortic cross-clamping the intramucosal pH value decreased in Group I patients , but did not change in Group II patients . Heart rate , cardiac index , and mixed venous oxygen saturation increased significantly during dopexamine infusion , whereas systemic vascular resistance was reduced . During aortic cross-clamping dopexamine was a useful agent in improving splanchnic blood flow , cardiac index venous saturation . Also , since the drug produces dose related hemodynamic changes of rapid onset and reversibility , it is possible to interrupt the infusion before aortic declamping to avoid the decrease in the intramucosal pH value .
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Intervention_Pharmacological
dopexamine
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Intervention_Pharmacological
dopexamine
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Intervention_Control
did not receive a dopexamine infusion
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Intervention_Pharmacological
dopexamine
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Outcome_Physical
intramucosal pH value
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Outcome_Physical
Heart rate , cardiac index , and mixed venous oxygen saturation
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Outcome_Physical
systemic vascular resistance
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Outcome_Physical
splanchnic blood flow , cardiac index venous saturation