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document
Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder . Autism is a neurodevelopmental disorder characterized by impairment in three core symptom domains : socialization , communication , and repetitive/stereotyped behaviours . Other associated symptom domains are also affected including impulsivity/aggression , self-injury , anxiety , and mood lability . Divalproex has been shown to have efficacy in treating epilepsy , bipolar disorder , mood lability , and impulsive aggression . The present study evaluated the use of divalproex in the treatment of repetitive , compulsive-like symptoms of autism spectrum disorder ( ASD ) . Thirteen individuals with ASD participated in an 8-wk , double-blind , placebo-controlled trial of divalproex sodium vs. placebo . There was a significant group difference on improvement in repetitive behaviours as measured by the Children 's Yale-Brown Obsessive Compulsive Scale ( C-YBOCS ) ( p=0.037 ) and a large effect size ( d=1.616 ) . This study provides preliminary support for the use of divalproex in treating repetitive behaviours in ASD . Further research is needed to evaluate the specificity and mechanism of action of these findings .
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Intervention_Pharmacological
Divalproex sodium
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Intervention_Pharmacological
Divalproex
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Intervention_Pharmacological
divalproex
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
divalproex sodium
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Intervention_Control
placebo
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Intervention_Pharmacological
divalproex
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Outcome_Mental
repetitive behaviours
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Outcome_Physical
repetitive , compulsive-like symptoms of autism spectrum disorder
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Outcome_Mental
repetitive behaviours
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Outcome_Mental
Children 's Yale-Brown Obsessive Compulsive Scale ( C-YBOCS )
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Outcome_Mental
repetitive behaviours
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Participant_Condition
autism spectrum disorder
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Participant_Condition
compulsive-like symptoms
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Participant_Condition
autism spectrum disorder ( ASD )
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Participant_Sample-size
Thirteen
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Participant_Condition
ASD
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Participant_Condition
ASD