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Risk factors for fracture in a UK population : a prospective cohort study . BACKGROUND Common clinical risk factors for fracture in older women have been identified . To date , most of these risk factors have not been confirmed in a UK population . AIM To confirm the important risk factors for fracture in older women . DESIGN Comprehensive cohort study ( CCS ) with a nested randomized controlled trial . METHODS The CCS included 4292 women aged > 70 years . We assessed potential risk factors for fracture , and followed-up participants for 24 months for incidence of non-vertebral fractures . RESULTS Odds ratios ( ORs ) for predicting any non-vertebral fracture were : previous fracture , 2.67 ( 95 % CI 2.10-3.40 ) ; a fall in the last 12 months , 2.06 ( 95 % CI 1.63-2.59 ) ; and age ( per year increase ) , 1.03 ( 95 % CI 1.01-1.05 ) . ORs for predicting hip fracture were : previous fracture , 2.31 ( 95 % CI 1.31-4.08 ) ; low body weight ( < 58 kg ) , 2.20 ( 95 % CI 1.28-3.77 ) ; maternal history of hip fracture , 1.68 ( 95 % CI 0.85-3.31 ) ; a fall in the last 12 months , 2.92 ( 95 % CI 1.70-5.01 ) ; and age ( per year increase ) , 1.09 ( 95 % CI 1.04-1.13 ) . ORs for predicting wrist fracture were : previous fracture , 2.29 ( 95 % CI 1.56-3.34 ) ; and a fall in the last 12 months , 1.60 ( 95 % CI 1.10-2.31 ) . Being a current smoker was not associated with an increase in risk , and was consistent across all fracture types . DISCUSSION Older women with the clinical risk factors identified in this study should be investigated for osteoporosis or offered preventive treatment .
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Intervention_Educational
Risk factors for fracture
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Intervention_Educational
cohort study .
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Intervention_Educational
risk factors for fracture
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Intervention_Educational
risk factors for fracture
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Intervention_Educational
Comprehensive cohort study ( CCS )
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Intervention_Control
controlled trial .
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Intervention_Educational
CCS
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Intervention_Educational
risk factors for fracture
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Outcome_Physical
previous fracture
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Outcome_Physical
a fall in the last 12 months
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Outcome_Other
age
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Outcome_Physical
previous fracture
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Outcome_Physical
low body weight
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Outcome_Physical
maternal history of hip fracture
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Outcome_Physical
a fall in the last 12 months
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Outcome_Other
age
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Outcome_Physical
previous fracture
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Outcome_Physical
a fall in the last 12 months
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Outcome_Mental
current smoker