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document
Oxidized Regenerated Cellulose Reduces the Amount of Fluid Drainage after Liver Resection : A Randomized Prospective Clinical Trial . BACKGROUND/AIMS Oxidized regenerated cellulose ( ORC ) has been registered as adjuncts to stimulate hemostasis in liver surgery . However , most previous studies were primarily designed to study the intra-operative hemostatic efficacy , and the effect on prophylactic application was never studied as a primary endpoint . This randomized prospective clinical trial was undertaken to evaluate whether ORC is safe and effective when used as a prophylactic agent covering the raw cut surface during the hepatectomy to reduce the volume and duration of drainage . METHODOLOGY Between June 2011 and August 2012 , a total of 40 patients undergoing major hepatectomy were randomly assigned to ORC or control groups ( 20 in each group ) . Patient characteristics , resection-related factors , debit of drainage and postoperative complications were compared between the two groups . RESULTS The two groups were comparable in terms of demographics , indications for surgery , extent of hepatectomy , and intraoperative blood loss . The amount of drainage after operation was significantly less in the ORC group compared with the control group ( 406.9 ± 308.1 vs. 627.0 ± 301.6 ml , P = 0.028 ) . CONCLUSIONS Application of ORC covering the raw cut surface during the hepatectomy can significantly decrease the amount of drainage .
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Intervention_Pharmacological
Oxidized Regenerated Cellulose
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Intervention_Pharmacological
Oxidized regenerated cellulose ( ORC )
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Intervention_Pharmacological
ORC
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Intervention_Pharmacological
ORC
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Intervention_Control
control groups
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Outcome_Other
debit of drainage
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Outcome_Adverse-effects
postoperative complications
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Outcome_Physical
indications for surgery
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Outcome_Physical
hepatectomy
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Outcome_Adverse-effects
intraoperative blood loss
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Outcome_Other
amount of drainage after operation
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Participant_Condition
hepatectomy
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Participant_Sample-size
40 patients
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Participant_Condition
hepatectomy
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Participant_Condition
hepatectomy