75406
document
Outpatient management of asthma with regular nebulized beta agonists : comparison of bitolterol mesylate and isoproterenol . Nebulized bitolterol solution and isoproterenol solution were compared when used on a regular basis , 2.5 mg three times a day for 1 month by patients with chronic asthma . In this multicenter , double-blind trial ; 130 nonsteroid-dependent patients were randomized to receive one of the two treatments concomitantly with their regular asthma medications . On study days , at the beginning of the study and after 2 and 4 weeks , treatments were given in the office or laboratory and patients were monitored with pulmonary function tests for eight hours . Both medications induced rapid bronchodilation that had a longer duration after bitolterol . The incidence of tremor was similar with the two medications . Tachycardia and palpitations were more frequent following isoproterenol . Bitolterol has a much longer duration of action and should be considered as a suitable bronchodilator for regular nebulizer treatment of chronic asthma .
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Intervention_Pharmacological
bitolterol mesylate
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Intervention_Pharmacological
isoproterenol
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Intervention_Pharmacological
Nebulized bitolterol solution
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Intervention_Pharmacological
isoproterenol solution
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Intervention_Pharmacological
Bitolterol
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Outcome_Other
pulmonary function tests
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Outcome_Physical
rapid bronchodilation
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Outcome_Other
duration
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Outcome_Physical
incidence of tremor
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Outcome_Physical
Tachycardia and palpitations
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Outcome_Other
duration of action
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Participant_Condition
Outpatient management of asthma
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Participant_Condition
patients with chronic asthma .
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Participant_Sample-size
130