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document
Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients : a randomized clinical trial . BACKGROUND AND AIMS This study evaluated the use of perioperative nutritional support on Quality of Life ( QOL ) in malnourished head and neck cancer patients undergoing surgery . METHODS 49 Malnourished ( weight loss > 10 % ) head and neck cancer patients who were included in a nutrition intervention trial were randomized to receive either no preoperative and standard postoperative tube-feeding ( group I ) , standard preoperative and postoperative tube-feeding ( group II ) or arginine-supplemented preoperative and postoperative tube-feeding ( group III ) . Of these patients , 31 completed a full QOL assessment on the first day of preoperative nutritional support , one day before surgery , and 6 months after surgery . Both a disease-specific ( EORTC QLQ-C30 ) and a generic questionnaire ( COOP-WONCA ) were used . One way analysis of variance ( ANOVA ) and the Kruskal-Wallis test were applied for testing differences in scores between groups . RESULTS Between baseline and the day before surgery , both preoperatively fed groups revealed a positive change for the dimensions physical and emotional functioning and dyspnea ( with significance in group II , P=0.050,0.031,0.045 respectively ) . Group III showed a negative change in appetite ( P=0.049 ) . Between baseline and 6 months after surgery , there were no differences between group I and both pre-fed groups . There were no differences in favour of group III compared to group II . CONCLUSION Enteral nutrition improves QOL of severely malnourished head and neck cancer patients in the period preceding surgery . No benefit of preoperative enteral feeding on QOL could be demonstrated 6 months after surgery .
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Intervention_Physical
perioperative nutritional support
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Intervention_Physical
no preoperative and standard postoperative tube-feeding ( group I ) , standard preoperative and postoperative tube-feeding ( group II )
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Intervention_Physical
arginine-supplemented preoperative
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Intervention_Physical
postoperative tube-feeding
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Intervention_Physical
preoperatively fed
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Intervention_Physical
both pre-fed groups
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Intervention_Physical
Enteral nutrition
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Intervention_Physical
preoperative enteral feeding
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Outcome_Other
quality of life
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Outcome_Other
Quality of Life ( QOL )
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Outcome_Other
QOL assessment
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Outcome_Mental
physical and emotional functioning
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Outcome_Physical
dyspnea
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Outcome_Physical
appetite
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Outcome_Other
QOL
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Outcome_Other
QOL
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Participant_Condition
head and neck cancer
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Participant_Condition
head and neck cancer
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Participant_Sample-size
49
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Participant_Condition
head and neck cancer