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document
Untoward effects of fenfluramine in autistic children . Several recent studies have described the benefits of fenfluramine for the symptomatic treatment of infantile autism . No large surveys of side effects of this drug have been reported in autistic children . To evaluate the untoward effects of fenfluramine in children with autism , 12 subjects were systematically studied . Medication was administered in a double-blind , placebo-controlled cross-over study . Parents were trained in monitoring untoward effects . These observations were compiled in detailed daily notes . In addition , four cases describing unusual effects found in a sample of 170 patients treated with fenfluramine are also reported . In the initial 2 weeks of active drug listlessness , food refusal , and stomach upset were frequently seen . A different pattern of untoward effects was seen in the final 14 weeks of treatment . Irritability , agitation , and crying along with continued food refusal were noted . The subjects lost 2.1 % of body weight during active drug phase , but there was a rebound weight gain during the subsequent placebo phase . A thorough understanding of fenfluramine 's side effects and adverse reactions is necessary so as to differentiate them from the multiple symptoms inherent in the syndrome of autism .
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Intervention_Pharmacological
fenfluramine
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Intervention_Pharmacological
fenfluramine
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Intervention_Pharmacological
fenfluramine
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
fenfluramine
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Intervention_Control
placebo
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Intervention_Pharmacological
fenfluramine 's
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Outcome_Mental
food refusal
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Outcome_Physical
stomach upset
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Outcome_Adverse-effects
untoward effects
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Outcome_Mental
Irritability , agitation , and crying along with continued food refusal
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Outcome_Physical
body weight
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Outcome_Physical
rebound weight gain
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Participant_Age
children
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Participant_Age
infantile
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Participant_Condition
autism .
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Participant_Sample-size
12
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Participant_Sample-size
four
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Participant_Sample-size
sample of 170 patients