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document
Beta-adrenoceptor blockade and cardiovascular response to the cold pressor test . Seven healthy subjects immersed a hand in random order in either warm water or in cold water at 5 degrees C for 2 min , after taking orally a single dose of 120 mg of propranolol or a placebo in a double blind fashion . The cold stress resulted in a significant increase in blood pressure and the rate pressure product without a change in heart rate . Beta-adrenoceptor blockade did not affect the pressor response the cold . The changes induced by the cold stress in the cardiovascular variables in the placebo and propranolol experiments were not statistically different . The highest rate pressure product during the cold pressor test was about 109 units . This was well below the pain threshold value of about 200 found during exercise in patients with ischaemic heart disease . In the recovery phase , the cardiovascular variables reverted to pre-immersion values within 1 min inspite of continued low hand skin temperature .
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Intervention_Pharmacological
propranolol
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Intervention_Control
placebo
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Outcome_Physical
cardiovascular response
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Outcome_Physical
blood pressure
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Outcome_Physical
rate pressure product
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Outcome_Physical
heart rate .
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Outcome_Physical
pressor response the cold .
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Outcome_Physical
cardiovascular variables
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Outcome_Physical
rate pressure product
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Outcome_Physical
pain threshold
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Outcome_Physical
cardiovascular variables