38291
document
Altered growth hormone response after growth hormone releasing hormone administration in chronic renal failure . Eleven chronic renal failure patients and 11 matched controls , received growth hormone GHRH ( 1 microgram/kg iv ) or TRH ( 400 microgram iv ) on separate occasions , immediately before undergoing hemodialysis . GHRH-induced GH peak in uremics ( 22.7 +/- 5.2 micrograms/l ) was not different from that obtained in control subjects ( 16.0 +/- 4.3 micrograms/l ) . However , the uremic patients did not show the habitual post-peak fall , remaining GH levels over 10 micrograms/l till the end of the test . Differences between the two groups were significant ( p less than 0.05 ) . Uremic patients showed PRL values higher than in controls , however their TRH-induced PRL peak ( 20.6 +/- 6.6 micrograms/l ) was not different from that of controls ( 26.5 +/- 3.0 micrograms/l ) . Again chronic renal failure patients showed PRL plasma values abnormally elevated till the end of the test . Differences between the two groups were significant ( p less than 0.05 ) . Administration of placebo to a different group of seven uremic patients did not alter GH and PRL plasma levels . This sustained secretion of both GH and PRL in uremia could be attributed to reduced kidney clearance . However , when subjects were examined individually both the GHRH- and the TRH-induced hormonal peaks and the subsequent fall were not different in both groups . Unlike with controls , in uremic patients GHRH-stimulated GH and TRH-stimulated PRL/GH peaks were dispersed throughout the 120 min period . In controls GH and PRL peaks clustered around 15-30 min . The peak dispersion created a false impression of flattened curves or sustained hypersecretion in uremia . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
growth hormone releasing hormone
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Intervention_Pharmacological
growth hormone GHRH
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Intervention_Pharmacological
TRH
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Intervention_Pharmacological
GHRH-induced
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Intervention_Pharmacological
TRH-induced
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Intervention_Control
placebo
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Intervention_Pharmacological
GHRH-
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Intervention_Pharmacological
TRH-induced
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Intervention_Pharmacological
GHRH-stimulated
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Intervention_Pharmacological
TRH-stimulated
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Outcome_Physical
growth hormone response
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Outcome_Physical
GH levels
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Outcome_Physical
PRL values
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Outcome_Physical
TRH-induced PRL peak
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Outcome_Physical
PRL plasma values
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Outcome_Physical
GH and PRL plasma levels
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Outcome_Physical
GH and PRL
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Outcome_Physical
GHRH- and the TRH-induced hormonal peaks and the subsequent fall
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Outcome_Physical
PRL/GH peaks
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Outcome_Physical
GH and PRL
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Participant_Condition
Eleven chronic renal failure
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Participant_Condition
11
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Participant_Condition
uremic