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document
Baseline characteristics of participants in the Appropriate Blood Pressure Control in Diabetes trial . The ABCD ( Appropriate Blood Pressure Control in Diabetes ) trial is a large , prospective , randomized clinical trial designed to compare the effects of intensive with moderate blood pressure control on the prevention and progression of diabetic nephropathy , retinopathy , cardiovascular disease , and neuropathy in non-insulin-dependent diabetes ( NIDDM ) . The secondary objective is to determine equivalency of the effects of a calcium channel blocker ( nisoldipine ) and of an angiotensin-converting enzyme inhibitor ( enalapril ) as a first-line antihypertensive agent in the prevention and/or progression of these diabetic vascular complications . The study consists of two study populations : a hypertensive one ( diastolic blood pressure of > or = 90.0 mm Hg at the time of randomization ) and a normotensive one ( diastolic blood pressure of 80.0-89.0 mm Hg at the time of randomization ) . A total of 950 men and women aged 40-74 years were randomized and are being followed for 5 years at a single center . There were 470 randomized participants in the hypertensive population and 480 randomized participants in the normotensive population . This report summarizes the demographic , biochemical , and clinical characteristics of the randomized patients at the time of entry into the trial and evaluates the balance between the treatment groups within each population .
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Intervention_Physical
moderate blood pressure control
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Intervention_Pharmacological
calcium channel blocker
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Intervention_Physical
(
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Intervention_Pharmacological
nisoldipine
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Intervention_Physical
)
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Intervention_Pharmacological
angiotensin-converting enzyme inhibitor
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Intervention_Physical
(
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Intervention_Pharmacological
enalapril
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Intervention_Physical
)
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Outcome_Physical
diastolic blood pressure
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Outcome_Physical
diastolic blood pressure
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Participant_Condition
participants in the Appropriate Blood Pressure Control in Diabetes trial .
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Participant_Condition
two study populations : a hypertensive one ( diastolic blood pressure of > or = 90.0 mm Hg at the time of randomization ) and a normotensive one ( diastolic blood pressure of 80.0-89.0 mm Hg at the time of randomization ) .