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document
[ Local application of anti-cancer drugs for the treatment of malignant pleural and pericardial effusion ] . Pleural effusion is a common complication in patients with malignant neoplasm . A randomized controlled study of intrapleural instillation of Adriamycin ( control group , 30 patients ) and Adriamycin Nocardia rubra cell wall skeleton ( N-CWS group , 26 patients ) with tube thoracostomy was performed in 55 patients with malignant pleural effusion due to primary lung cancer . The response rates for control of pleural effusion were 73.4 % in the N-CWS group and 46.1 % in the N-CWS group . These results suggest that intrapleural instillation using a combination of anti-cancer agent and immunopotentiator is an effective treatment for malignant pleurisy . Cardiac tamponade secondary to cancer is a life-threatening complication requiring immediate treatment . Twenty-four patients with malignant pericardial effusion were treated by intrapericardial instillation of anti-cancer drugs , such as Carbazilquinone , Mitomycin-C or ACNU , with pericardial drainage . The range of survival time from the instillation of anti-cancer drug was 3-365 days ( average days ) . In only 4 patients , reaccumulation of pericardial effusion was recognized . There were no serious complications with this procedure . It was considered that local instillation of anti-cancer agents with pericardial drainage was a useful therapeutic modality for malignant pericarditis .
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Intervention_Pharmacological
anti-cancer drugs
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Intervention_Control
Adriamycin
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Intervention_Pharmacological
Adriamycin Nocardia rubra cell wall skeleton
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Intervention_Surgical
tube thoracostomy
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Intervention_Pharmacological
N-CWS group
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Intervention_Pharmacological
N-CWS group
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Intervention_Pharmacological
anti-cancer agent and immunopotentiator
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Intervention_Pharmacological
anti-cancer drugs
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Intervention_Pharmacological
Carbazilquinone , Mitomycin-C
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Intervention_Pharmacological
ACNU
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Intervention_Pharmacological
anti-cancer drug
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Intervention_Pharmacological
anti-cancer agents
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Outcome_Physical
control of pleural effusion
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Outcome_Mortality
range of survival time
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Outcome_Physical
reaccumulation of pericardial effusion
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Participant_Condition
malignant pleural and pericardial effusion ]
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Participant_Condition
patients with malignant neoplasm .