548
document
A comparison of a non-ionic dimer , iodixanol with a non-ionic monomer , iohexol in low dose intravenous urography . A prospective , double-blind study of 392 patients randomized into four groups was performed to establish whether diagnostic intravenous urograms could be obtained with a lower dose of iodine when using the dimeric , non-ionic contrast medium iodixanol compared with the monomeric , non-ionic iohexol . Patients received iodixanol or iohexol containing either 9 or 12 g of iodine ( gI ) . The primary parameter was the diagnostic quality of the 6 min film , assessed in a blinded fashion , by consensus , by four radiologists . Iodixanol at both doses was diagnostic in over 90 % of cases . Iohexol was only diagnostic in 74 % ( 9 gI ) and 81.8 % ( 12 gI ) . Pairwise comparisons revealed that iodixanol 9 gI was significantly better than both iohexol 9 gI ( p = 0.0005 ) and 12 gI ( p = 0.014 ) . No significant difference was present for different doses within the same contrast medium group . Iodixanol resulted in poorer bladder distension than iohexol . Iodixanol caused significantly less discomfort than iohexol .
549
Intervention_Pharmacological
non-ionic dimer
550
Intervention_Pharmacological
iodixanol
551
Intervention_Pharmacological
a non-ionic monomer , iohexol
552
Intervention_Pharmacological
non-ionic contrast medium iodixanol
553
Intervention_Pharmacological
monomeric , non-ionic iohexol
554
Intervention_Pharmacological
iodixanol or iohexol
555
Intervention_Pharmacological
iodine
556
Intervention_Pharmacological
Iodixanol
557
Intervention_Pharmacological
Iohexol
558
Intervention_Pharmacological
iohexol
559
Intervention_Pharmacological
Iodixanol
560
Intervention_Pharmacological
iohexol . Iodixanol
561
Intervention_Pharmacological
iohexol .
562
Outcome_Other
diagnostic quality
563
Outcome_Other
diagnostic
564
Outcome_Other
diagnostic
565
Outcome_Physical
poorer bladder distension
566
Outcome_Physical
significantly less discomfort
567
Participant_Condition
low dose intravenous urography