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document
Leucocyte depletion of perioperative blood transfusion does not affect long-term survival and recurrence in patients with gastrointestinal cancer . BACKGROUND Perioperative red blood cell ( RBC ) transfusion may be associated with a poor prognosis in cancer surgery . Allogeneic leucocytes are assumed to play a causal role . This study evaluated the long-term effect of transfusion with leucocyte-depleted ( LD ) blood in patients with gastrointestinal cancer . METHODS The Transfusion Associated Complications = Transfusion Induced Complications ? ( TACTIC ) study is a multicentre randomized controlled trial evaluating the short-term benefits of LD versus non-LD RBC transfusions . The present study evaluated 5-year survival and cancer recurrence among 512 patients with gastrointestinal cancer included in the TACTIC study . RESULTS Some 89.2 per cent of patients had a primary tumour and 79.7 per cent underwent surgery with curative intent ; 243 patients received perioperative RBC transfusion ( median 3 units ) . The 5-year overall survival rate of patients with any type of gastrointestinal cancer was 50.8 per cent in the LD group and 45.8 per cent in the non-LD group ( P = 0.191 ) . Corresponding 5-year disease-free survival rates were 60.0 and 56.6 per cent ( P = 0.482 ) , and recurrence rates 32.9 and 34.3 per cent ( P = 0.864 ) . CONCLUSION Leucocyte depletion is not associated with better long-term survival and lower recurrence rates in patients with gastrointestinal cancer .
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Intervention_Pharmacological
perioperative blood transfusion
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Intervention_Pharmacological
Perioperative red blood cell ( RBC ) transfusion
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Intervention_Physical
transfusion with leucocyte-depleted
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Intervention_Pharmacological
LD versus
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Intervention_Physical
non-LD RBC transfusions
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Intervention_Surgical
surgery
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Intervention_Physical
perioperative RBC transfusion
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Outcome_Mortality
long-term survival
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Outcome_Physical
leucocyte-depleted
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Outcome_Physical
perioperative RBC transfusion
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Outcome_Mortality
5-year overall survival rate of patients with any type of gastrointestinal cancer
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Outcome_Mortality
5-year disease-free survival rates
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Outcome_Physical
recurrence rates
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Outcome_Mortality
long-term survival
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Outcome_Physical
lower recurrence rates
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Participant_Condition
gastrointestinal cancer
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Participant_Condition
gastrointestinal cancer
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Participant_Sample-size
512
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Participant_Condition
gastrointestinal cancer
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Participant_Condition
primary tumour
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Participant_Sample-size
243
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Participant_Condition
gastrointestinal cancer