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document
B-vitamins reduce plasma levels of beta amyloid . Elevated plasma homocysteine ( tHcy ) is a risk factor for Alzheimer 's disease ( AD ) , and thus B vitamins may have a role in the prevention of AD . The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 ( A beta 40 ) . We randomized 299 older men to treatment with 2mg of folate , plus 25mg of B6 and 400 microg of B12 , or placebo . After 2 years of treatment the mean ( S.E . ) increase of A beta 40 was 7.0 pg/ml ( 8.4 ) in the vitamin group ( 4.9 % ) , and 26.8 pg/ml ( 7.7 ) ( 18.5 % ) in the placebo group . We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD .
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Intervention_Pharmacological
B-vitamins
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Intervention_Pharmacological
B vitamins
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Intervention_Pharmacological
2mg of folate
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Intervention_Pharmacological
plus 25mg of B6
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Intervention_Pharmacological
400 microg of B12
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Intervention_Control
placebo
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Outcome_Physical
plasma levels
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Outcome_Physical
circulating levels of A-beta protein 1-40 ( A beta 40 )
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Outcome_Physical
mean ( S.E . ) increase of A beta 40
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Outcome_Physical
the plasma level of A beta 40