46796
document
Effects of two combined hormonal contraceptives with the same composition and different doses on female sexual function and plasma androgen levels . BACKGROUND This study was conducted to compare the effects of two contraceptive pills with different doses of the same components , on plasma androgen levels and female sexual function among women without previous sexual dysfunction . STUDY DESIGN The participants were randomized into two groups , to receive pills containing ethynylestradiol ( EE ) 30 mcg and levonorgestrel ( LNG ) 150 mcg or EE 20 mcg and LNG 100 mcg , for six cycles . Sexual function was assessed using a standardized questionnaire [ Female Sexual Function Index ( FSFI ) ] . Hormone assays were performed at baseline and after the sixth cycle . RESULTS Forty-nine women were included in the EE30/LNG150 group and 48 in the EE20/LNG100 group . EE30/LNG150 group presented 54 % and 67 % decreases of total testosterone and free androgen index , respectively , with statistical significance . EE20/LNG100 presented reductions of 20 % and 42 % , respectively , but without statistical significance . Both groups showed improvements in the FSFI " desire " score , but with statistical significance only for EE20/LNG100 group . CONCLUSIONS EE30/LNG150 decreased plasma androgen levels , but there was no impairment in sexual desire , on the other hand , sexual desire score increased with EE20/LNG100 formulation .
46797
Intervention_Pharmacological
hormonal contraceptives
46798
Intervention_Pharmacological
contraceptive pills
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Intervention_Pharmacological
ethynylestradiol ( EE ) 30 mcg and levonorgestrel ( LNG ) 150 mcg or EE 20 mcg and LNG 100 mcg
46800
Intervention_Pharmacological
EE30/LNG150
46801
Intervention_Pharmacological
EE20/LNG100
46802
Intervention_Pharmacological
EE30/LNG150
46803
Intervention_Pharmacological
EE20/LNG100
46804
Intervention_Pharmacological
EE20/LNG100
46805
Intervention_Pharmacological
EE30/LNG150
46806
Intervention_Pharmacological
EE20/LNG100
46807
Outcome_Physical
plasma androgen levels
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Outcome_Mental
female sexual function among women without previous sexual dysfunction
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Outcome_Mental
Sexual function
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Outcome_Physical
Hormone assays
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Outcome_Physical
total testosterone and free androgen index
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Outcome_Mental
FSFI " desire " score
46813
Participant_Condition
female