47420
document
Anti-angiogenic effects of epigallocatechin-3-gallate in human skin . Epigallocatechin-3-gallate ( EGCG ) is the main polyphenol component of green tea . This compound exhibits antioxidant , immunomodulatory , photoprotective , anti-angiogenic , and anti-inflammatory properties . We conducted a small randomized , double blind , split face trial using a cream containing 2.5 % w/w of EGCG . Four healthy volunteers with significant erythema and telangiectasia on the face applied EGCG cream to one side of the face , and vehicle control cream to the other , twice daily for six weeks . After six weeks , biopsies were taken from EGCG and vehicle treated sites . Immunohistochemistry was used to measure VEGF and HIF-1 α. HIF-1 α expression was decreased in EGCG treated sites , such that 28.4 % of the epidermis showed positive staining in vehicle treated vs. 13.8 % in EGCG treated sites ( p < 0.001 ) . A similar decrease in VEGF expression was found ( 6.7 % in EGCG vs. 11.0 % in in vehicle-treated skin ( p < 0.005 ) . EGCG topical treatments influence HIF-1 α induction and VEGF expression and may serve as a potential agent in the prevention of telangiectasias .
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Intervention_Pharmacological
epigallocatechin-3-gallate
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Intervention_Pharmacological
Epigallocatechin-3-gallate ( EGCG )
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Intervention_Pharmacological
cream containing 2.5 % w/w of EGCG .
47424
Intervention_Pharmacological
EGCG cream
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Intervention_Pharmacological
vehicle control cream
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Intervention_Pharmacological
EGCG
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Intervention_Other
vehicle treated
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Outcome_Physical
Anti-angiogenic effects
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Outcome_Physical
antioxidant
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Outcome_Physical
immunomodulatory
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Outcome_Physical
photoprotective
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Outcome_Physical
anti-angiogenic
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Outcome_Physical
anti-inflammatory properties
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Outcome_Other
biopsies
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Participant_Sample-size
Four
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Participant_Condition
healthy
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Participant_Condition
significant erythema and telangiectasia on the face