31147
document
Propofol and midazolam act synergistically in combination . We have studied interactions between i.v . propofol and midazolam for induction of anaesthesia in 200 unpremedicated female patients undergoing elective gynaecological surgery . Using end-points of " hypnosis " ( loss of response to verbal command ) and " anaesthesia " ( loss of response to a 5-s transcutaneous tetanic stimulus ) , we determined dose-response curves for propofol and midazolam alone and in combination . For hypnosis , synergistic interaction was found ( P less than 0.01 ) , the combination having 1.44 times the potency of the individual agents . Although midazolam failed to produce anaesthesia in the dose range used , the dose of propofol required to produce anaesthesia was reduced by 52 % in the presence of midazolam ( P less than 0.01 ) . The reduction in arterial pressure at induction was the same for the combination as for the individual agents . The cause of the synergism was not clear , but may have been interaction at CNS GABAA receptors .
31148
Intervention_Pharmacological
Propofol
31149
Intervention_Pharmacological
midazolam
31150
Intervention_Pharmacological
propofol
31151
Intervention_Pharmacological
midazolam
31152
Intervention_Pharmacological
propofol
31153
Intervention_Pharmacological
midazolam
31154
Intervention_Pharmacological
midazolam
31155
Intervention_Pharmacological
propofol
31156
Intervention_Pharmacological
midazolam
31157
Outcome_Mental
" hypnosis " ( loss of response to verbal command )
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Outcome_Mental
" anaesthesia " ( loss of response to a 5-s transcutaneous tetanic stimulus
31159
Outcome_Mental
hypnosis , synergistic interaction
31160
Outcome_Mental
required to produce anaesthesia
31161
Outcome_Physical
arterial pressure at induction
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Participant_Condition
induction of anaesthesia in 200 unpremedicated female patients undergoing elective gynaecological surgery .