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document
Low protein provision during the first year of life , but not during foetal life , affects metabolic traits , organ mass development and growth in male mink ( Neovison vison ) . Low protein provision in utero and post-partum may induce metabolic disorders in adulthood . Studies in mink have mainly focused on short-term consequences of low protein provision in utero whereas the long-term responses to low protein ( LP ) provision in metabolically programmed mink are unknown . We investigated whether low protein provision in utero affects the long-term response to adequate ( AP ) or LP provision after weaning in male mink . Eighty-six male mink were exposed to low ( 19 % of ME from CP ; crude protein ) or adequate ( 31 % of ME from CP ) protein provision in utero , and to LP ( ~20 % of ME from CP ) or AP ( 30-42 % of ME from CP ) provision post-weaning . Being metabolically programmed by low protein provision in utero did not affect the response to post-weaning diets . Dietary protein content in the LP feed after weaning was below requirements ; evidenced by lower nitrogen retention ( p < 0.001 ) preventing LP mink from attaining their growth potential ( p < 0.02 ) . LP mink had a lower liver , pancreas and kidney weight ( p < 0.05 ) as well as lower plasma IGF-1 concentrations at 8 and 25 ( p < 0.05 ) weeks , and a higher incidence of hepatic lipidosis at 25 weeks ( p < 0.05 ) . Furthermore , LP mink had a higher body fat ( p < 0.05 ) and lower body CP content ( p < 0.05 ) at 50 weeks of age . It is concluded that some effects of low protein provision in utero can be alleviated by an adequate nutrient supply post-partum . However , long-term exposure to low protein provision in mink reduces their growth potential and induces transient hepatic lipidosis and modified body composition .
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Intervention_Physical
Low protein provision
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Intervention_Physical
Low protein
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Intervention_Physical
low protein provision
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Intervention_Physical
low protein ( LP ) provision
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Intervention_Physical
low protein
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Intervention_Physical
low protein provision in
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Intervention_Physical
low protein provision
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Outcome_Physical
metabolic traits
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Outcome_Physical
organ mass development and growth
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Outcome_Physical
metabolic disorders
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Outcome_Physical
post-weaning diets
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Outcome_Physical
Dietary protein content
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Outcome_Physical
liver , pancreas and kidney weight
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Outcome_Physical
plasma IGF-1 concentrations
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Outcome_Physical
hepatic lipidosis
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Outcome_Physical
higher body fat
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Outcome_Physical
lower body CP content
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Outcome_Physical
low protein provision
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Outcome_Physical
nutrient supply post-partum
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Outcome_Physical
growth potential
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Outcome_Physical
induces transient hepatic lipidosis and modified body composition