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document
Succinate sumatriptan evaluation by Doppler echocardiography in patients with migraine . Recent reports show that sumatriptan administration increases blood pressure and vascular resistance both in systemic and pulmonary circulation . This study was performed to evaluate by echo-Doppler technique the hemodynamic effects of subcutaneous sumatriptan administration . Forty-one migraine subjects ( 26 males , 15 females ) , mean age 36 +/- 2 years ( range 36-39 years ) , and 20 healthy control subjects ( 14 males , six females ) , mean age 36 +/- 2 years ( range 36-39 years ) were randomized ( double-blind ) to receiving sumatriptan ( group A ) or placebo ( group B ) . After a 2-week complete pharmacological washout , clinical examination , electrocardiogram , and Doppler echocardiography were performed at baseline , 15 , 30 , 45 , and 60 min after sumatriptan or placebo administration . No significant differences were found between the two groups regarding Doppler echocardiographic parameters ( aortic integral , pulmonary integral , end-systolic and end-diastolic diameters ) and heart rate ; only a slight but not significant increase in arterial blood pressure was observed in group A . Our data show that succinate sumatriptan can be used with safety in patients without hypertension and other cardiovascular disease .
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Intervention_Pharmacological
Succinate sumatriptan
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Intervention_Pharmacological
sumatriptan
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Intervention_Control
sumatriptan ( group A )
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Intervention_Control
placebo ( group B )
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Intervention_Pharmacological
succinate sumatriptan
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Outcome_Physical
blood pressure and vascular resistance
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Outcome_Physical
hemodynamic effects
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Outcome_Physical
aortic integral
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Outcome_Physical
pulmonary integral
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Outcome_Physical
end-systolic and end-diastolic diameters
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Outcome_Physical
heart rate
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Participant_Condition
patients with migraine .