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document
Relationships between age at diagnosis , clinical features , and outcome of therapy in children treated in the Medical Research Council AML 10 and 12 trials for acute myeloid leukemia . Between May 1988 and June 2000 , 698 children were treated in the Medical Research Council acute myeloid leukemia 10 and 12 trials . The presenting features and outcomes of therapy in these children were compared by age . Although there was no single cutoff in age , younger children were more likely to have intermediate risk and less likely to have favorable cytogenetics ( P < .001 ) , and they had a higher incidence of translocations involving chromosome 11q23 ( P < .001 ) . The distribution of French-American-British ( FAB ) types also varied with age ; FAB types M5 ( P < .001 ) and M7 ( P < .001 ) were more common in early childhood , whereas older children were more likely to have FAB types M0 ( P =.03 ) , M1 ( P =.04 ) , M2 ( P =.005 ) , and M3 ( P < .001 ) . Involvement of the central nervous system at diagnosis was also more common in the youngest children ( P =.01 ) . Younger children had more severe diarrhea ( P =.002 ) , whereas older children had worse nausea and vomiting ( P =.01 ) after chemotherapy . When adjusted for other important factors , complete remission rates were similar ( P =.5 ) and although there was less resistant disease in younger children ( P =.003 ) , this was partially balanced by a slight increase in deaths during induction therapy in younger patients ( P =.06 ) . On multivariate analysis overall survival ( P =.02 ) , event-free survival ( P =.02 ) , and disease-free survival were better ( P =.06 ) in younger children due to a lower relapse rate ( P =.02 ) especially in the bone marrow ( P =.02 ) .
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Intervention_Educational
features and outcomes of
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Intervention_Educational
in these children were compared by age
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Outcome_Physical
favorable cytogenetics
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Outcome_Physical
incidence of translocations involving chromosome 11q23
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Outcome_Other
FAB types M5
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Outcome_Other
M7
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Outcome_Other
FAB types M0
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Outcome_Other
M2
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Outcome_Other
M3
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Outcome_Physical
severe diarrhea
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Outcome_Adverse-effects
nausea and vomiting
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Outcome_Physical
complete remission rates
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Outcome_Mortality
deaths
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Outcome_Mortality
overall survival
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Outcome_Mortality
event-free survival
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Outcome_Adverse-effects
disease-free survival
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Outcome_Physical
relapse rate
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Participant_Age
children
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Participant_Condition
treated in the Medical Research Council AML 10 and 12 trials for acute myeloid leukemia .
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Participant_Sample-size
698
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Participant_Age
children
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Participant_Condition
acute myeloid leukemia