78802
document
Suppression of immediate and late anti-IgE-induced skin reactions by topically applied alcohol/onion extract . In a double blind study , alcohol/onion extract ( 5 % ethanol ) was injected simultaneously with 20 IU and 200 IU rabbit anti-human-IgE intradermally in 12 adult volunteers ( 6 atopics , 6 non-atopics ) . Diameters of wheals and flares were measured 10 min after and compared with control sites challenged with 20 IU and 200 IU anti-IgE in a 5 % ethanol solution . The skin sites were then treated epidermally with 45 % alcohol/onion extract and 45 % ethanol under occlusion . Diameters of late cutaneous reactions were measured hourly . Oedema formation was clinically estimated according to an arbitrary scale and skin thickness measured with a calliper . In the onion-treated skin sites the wheal areas were significantly reduced ( 20 IU : control : 108 +/- 53 mm2 ; onion 69 +/- 42 mm2 , P less than 0.05 ; 200 IU anti-IgE : control : 152 +/- 25 mm2 , onion : 138 +/- 26 mm2 , P less than 0.02 ) . The oedema formation during the late phase skin reaction was markedly depressed ( P less than 0.005 at 2 h , P less than 0.01 at 4 and 6 h , P less than 0.02 at 8 h ) . The extent of late skin reactions was slightly , but not significantly reduced . Obviously , onions contain pharmacologically active substances with anti-inflammatory and/or allergic properties .
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Intervention_Pharmacological
alcohol/onion extract .
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Intervention_Pharmacological
alcohol/onion extract ( 5 % ethanol )
78805
Intervention_Pharmacological
20 IU and 200 IU rabbit anti-human-IgE intradermally
78806
Intervention_Pharmacological
anti-IgE in a 5 % ethanol
78807
Intervention_Pharmacological
45 % alcohol/onion extract
78808
Intervention_Pharmacological
45 % ethanol
78809
Intervention_Pharmacological
onion-treated
78810
Intervention_Pharmacological
onions
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Outcome_Physical
anti-IgE-induced skin reactions
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Outcome_Physical
wheal areas
78813
Outcome_Physical
oedema formation
78814
Outcome_Physical
skin reactions
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Participant_Sample-size
12
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Participant_Condition
adult volunteers (
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Participant_Sample-size
6
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Participant_Condition
atopics ,
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Participant_Sample-size
6
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Participant_Condition
non-atopics ) .