62145
document
Do ACE inhibitors improve the response to exercise training in functionally impaired older adults ? A randomized controlled trial . BACKGROUND Loss of muscle mass and strength with ageing is a major cause for falls , disability , and morbidity in older people . Previous studies have found that angiotensin-converting enzyme inhibitors ( ACEi ) may improve physical function in older people . It is unclear whether ACEi provide additional benefit when added to a standard exercise training program . We examined the effects of ACEi therapy on physical function in older people undergoing exercise training . METHODS Community-dwelling people aged ≥ 65 years with functional impairment were recruited through general ( family ) practices . All participants received progressive exercise training . Participants were randomized to receive either 4 mg perindopril or matching placebo daily for 20 weeks . The primary outcome was between-group change in 6-minute walk distance from baseline to 20 weeks . Secondary outcomes included changes in Short Physical Performance Battery , handgrip and quadriceps strength , self-reported quality of life using the EQ-5D , and functional impairment measured using the Functional Limitations Profile . RESULTS A total of 170 participants ( n = 86 perindopril , n = 84 placebo ) were randomized . Mean age was 75.7 ( standard deviation [ SD ] 6.8 ) years . Baseline 6-minute walk distance was 306 m ( SD 99 ) . Both groups increased their walk distance ( by 29.6 m perindopril , 36.4 m placebo group ) at 20 weeks , but there was no statistically significant treatment effect between groups ( -8.6m [ 95 % confidence interval : -30.1 , 12.9 ] , p = .43 ) . No statistically significant treatment effects were observed between groups for the secondary outcomes . Adverse events leading to withdrawal were few ( n = 0 perindopril , n = 4 placebo ) . INTERPRETATION ACE inhibitors did not enhance the effect of exercise training on physical function in functionally impaired older people .
62146
Outcome_Other
response
62147
Outcome_Physical
exercise training
62148
Outcome_Physical
Loss of muscle mass and strength
62149
Outcome_Physical
falls , disability , and morbidity
62150
Outcome_Physical
physical function
62151
Outcome_Physical
physical function
62152
Participant_Condition
functionally impaired older adults