13175
document
Treatment of recurrent chronic hyperplastic sinusitis with nasal polyposis . OBJECTIVE To demonstrate the long-term efficacy of intranasal furosemide , an inhibitor of the sodium chloride cotransporter channel at the basolateral surface of the respiratory epithelial cell , vs no therapeutic intervention vs intranasal mometasone furoate , a corticosteroid , in preventing relapses of chronic hyperplastic sinusitis with nasal polyposis . DESIGN Randomized prospective controlled study . Patients were examined every 6 months during follow-up ( range , 1-9 years ) . PATIENTS One hundred seventy patients with bilateral obstructive or minimally obstructive chronic hyperplastic sinusitis with nasal polyposis . INTERVENTION All patients were surgically treated in the ENT Department , University of Siena Medical School . One month after surgery , group 1 patients ( n = 97 ) started treatment with intranasal furosemide , group 2 ( n = 40 ) received no therapeutic treatment , and group 3 ( n = 33 ) were treated with mometasone . MAIN OUTCOME MEASURES Clinical and instrumental evaluation of postoperative outcomes . RESULTS Seventeen ( 17.5 % ) of 97 patients in group 1 , 12 ( 30.0 % ) of 40 patients in group 2 , and 8 ( 24.2 % ) of 33 patients in group 3 experienced nasal polyposis relapses . We noted a prevalence of early-stage relapse in patients treated with furosemide or mometasone , whereas patients who did not receive any treatment experienced more severe grades of chronic hyperplastic sinusitis with nasal polyposis ( P < .005 ) . CONCLUSION Use of intranasal furosemide represents a valid therapeutic treatment in the prevention of chronic hyperplastic sinusitis with nasal polyposis .
13176
Intervention_Pharmacological
furosemide
13177
Intervention_Control
no therapeutic intervention
13178
Intervention_Pharmacological
mometasone furoate , a corticosteroid
13179
Intervention_Pharmacological
intranasal furosemide
13180
Intervention_Control
received no therapeutic treatment
13181
Intervention_Pharmacological
mometasone
13182
Intervention_Pharmacological
furosemide
13183
Intervention_Pharmacological
mometasone
13184
Intervention_Pharmacological
furosemide
13185
Outcome_Physical
nasal polyposis relapses .
13186
Outcome_Physical
early-stage relapse
13187
Outcome_Physical
grades of chronic hyperplastic sinusitis with nasal polyposis
13188
Participant_Condition
recurrent chronic hyperplastic sinusitis with nasal polyposis .
13189
Participant_Condition
One hundred seventy patients with bilateral obstructive or minimally obstructive chronic hyperplastic sinusitis with nasal polyposis .