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Do cognitive measures and brain circuitry predict outcomes of exercise in Parkinson Disease : a randomized clinical trial . BACKGROUND There is emerging research detailing the relationship between balance/gait/falls and cognition . Imaging studies also suggest a link between structural and functional changes in the frontal lobe ( a region commonly associated with cognitive function ) and mobility . People with Parkinson 's disease have important changes in cognitive function that may impact rehabilitation efficacy . Our underlying hypothesis is that cognitive function and frontal lobe connections with the basal ganglia and brainstem posture/locomotor centers are responsible for postural deficits in people with Parkinson 's disease and play a role in rehabilitation efficacy . The purpose of this study is to 1 ) determine if people with Parkinson 's disease can improve mobility and/or cognition after partaking in a cognitively challenging mobility exercise program and 2 ) determine if cognition and brain circuitry deficits predict responsiveness to exercise rehabilitation . METHODS/DESIGN This study is a randomized cross-over controlled intervention to take place at a University Balance Disorders Laboratory . The study participants will be people with Parkinson 's disease who meet inclusion criteria for the study . The intervention will be 6 weeks of group exercise ( case ) and 6 weeks of group education ( control ) . The exercise is a cognitively challenging program based on the Agility Boot Camp for people with PD . The education program is a 6-week program to teach people how to better live with a chronic disease . The primary outcome measure is the MiniBESTest and the secondary outcomes are measures of mobility , cognition and neural imaging . DISCUSSION The results from this study will further our understanding of the relationship between cognition and mobility with a focus on brain circuitry as it relates to rehabilitation potential . TRIAL REGISTRATION This trial is registered at clinical trials.gov ( NCT02231073 ) .
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Intervention_Physical
cognitively challenging mobility exercise program
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Intervention_Physical
exercise rehabilitation
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Intervention_Physical
6 weeks of group exercise ( case ) and 6 weeks of group education ( control )
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Intervention_Physical
cognitively challenging program based on the Agility Boot Camp
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Intervention_Educational
The education program
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Intervention_Educational
teach people how to better live with a chronic disease
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Outcome_Other
MiniBESTest
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Outcome_Mental
mobility , cognition and neural imaging .