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document
Removal of inflammatory cytokines and endotoxin by veno-venous continuous renal replacement therapy for burned patients with sepsis . OBJECTIVE To evaluate the effect of veno-venous continuous renal replacement therapy ( CRRT ) on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis . METHODS Twenty adult severely burned patients with sepsis were studied . For the diagnosis of sepsis , patients were randomly divided into CRRT ( n=10 ) and Control ( n=10 ) . Both groups received conventional therapy after admission . Veno-venous CRRT was administered to 10 patients in the CRRT group whenever patients were determined to be septic . The plasma level of endotoxin , TNF-alpha , IL-1 beta , IL-6 and IL-8 were measured at 0 , 1 , 2 , 6 , 12 , 36 and 60 h after CRRT initiation , and at 0 , 12 , 36 and 60 h after the patients were diagnosed as having sepsis in the Control group . MAIN RESULTS Plasma level of endotoxin and all the cytokines after CRRT initiation were significantly lower than those before the treatment ( P < 0.01 ) . The serial change of endotoxin , IL-1 beta , IL-6 and IL-8 was significantly lower at 12 , 36 and 60 h after treatment compared with Control groups ( P < 0.01 ) . A significant decrease in plasma TNF-alpha levels was seen at 36 and 60 h after treatment compared with Control groups ( P < 0.01 ) . CONCLUSION Plasma endotoxin and cytokines ( TNF-alpha , IL-1 beta , IL-6 and IL-8 ) can be removed effectively with CRRT in severely burned patients with sepsis .
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Intervention_Physical
veno-venous continuous renal replacement therapy
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Intervention_Physical
veno-venous continuous renal replacement therapy ( CRRT )
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Intervention_Physical
CRRT
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Intervention_Control
Control
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Intervention_Physical
conventional therapy
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Intervention_Physical
Veno-venous CRRT
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Outcome_Physical
Plasma level of endotoxin
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Outcome_Physical
all the cytokines after CRRT initiation
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Outcome_Physical
serial change of endotoxin , IL-1 beta , IL-6 and IL-8
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Outcome_Physical
plasma TNF-alpha levels
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Participant_Condition
burned patients
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Participant_Condition
sepsis
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Participant_Condition
severely burned patients
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Participant_Condition
sepsis
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Participant_Sample-size
Twenty
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Participant_Condition
severely burned patients with sepsis