18418
document
A prospective randomised comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancy . OBJECTIVE To compare the efficacy , side effects and acceptability of sublingual and vaginal misoprostol for second trimester medical abortion . DESIGN Prospective randomised controlled trial . SETTING Tertiary referral unit and a teaching hospital . POPULATION Two hundred and twenty-four women at 12 to 20 weeks of gestation . METHODS The women were randomised to receive either sublingual or vaginal misoprostol 400 microg every 3 hours for a maximum of five doses . The course of misoprostol was repeated if the woman did not abort within 24 hours . MAIN OUTCOME MEASURES The success rate at 48 hours , induction-to-abortion interval and the side effects . RESULTS There was no significant difference in the success rate at 48 hours ( sublingual : 91 % ; vaginal : 95 % ) . However , the success rate at 24 hours was significantly higher in the vaginal group ( 85 % ) compared with the sublingual group ( 64 % ) . There was no difference in the median induction-to-abortion interval ( sublingual : 13.8 hours ; vaginal : 12.0 hours ) . Significantly more women in the sublingual group preferred the route to which they were assigned when compared with the vaginal group . The incidence of fever was also less in the sublingual group . CONCLUSION The use of vaginal misoprostol for second trimester medical abortion resulted in a higher success rate than sublingual misoprostol at 24 hours but the abortion rate was similar at 48 hours . Vaginal misoprostol should be the regimen of choice but sublingual misoprostol is also an effective alternative .
18419
Intervention_Pharmacological
sublingual and vaginal misoprostol
18420
Intervention_Pharmacological
sublingual and vaginal misoprostol
18421
Intervention_Pharmacological
sublingual or vaginal misoprostol
18422
Intervention_Pharmacological
misoprostol
18423
Intervention_Pharmacological
vaginal misoprostol
18424
Intervention_Pharmacological
misoprostol
18425
Intervention_Pharmacological
Vaginal misoprostol
18426
Intervention_Pharmacological
sublingual misoprostol
18427
Outcome_Other
efficacy
18428
Outcome_Adverse-effects
side effects
18429
Outcome_Other
acceptability
18430
Outcome_Other
The success rate at 48 hours , induction-to-abortion interval
18431
Outcome_Adverse-effects
side effects
18432
Outcome_Other
the success rate at 48 hours
18433
Outcome_Other
success rate at 24 hours
18434
Outcome_Other
the median induction-to-abortion interval
18435
Outcome_Other
preferred the route
18436
Outcome_Adverse-effects
The incidence of fever
18437
Outcome_Other
success rate
18438
Outcome_Other
abortion rate
18439
Participant_Condition
sublingual and vaginal misoprostol in second trimester termination of pregnancy
18440
Participant_Condition
second trimester medical abortion .
18441
Participant_Sample-size
Two hundred and twenty-four women