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document
Intravenous lidocaine does not cause shivering-like tremor or alter thermoregulation . We tested the hypotheses that systemic absorption of epidural lidocaine : ( 1 ) contributes to the shivering-like tremor seen during epidural anesthesia by causing central nervous system disinhibition of spinal reflexes , or ( 2 ) activates or alters thermoregulatory mechanisms . In a double-blind , placebo , cross-over study , nine healthy volunteers were given intravenous lidocaine ( or saline ) to approximate the plasma levels of lidocaine achieved during epidural anesthesia for major abdominal surgery . Five volunteers were studied in a warm room ( to test for nonthermoregulatory tremor ) , and four volunteers were studied in a cold room ( to test the effects of lidocaine on normal thermoregulation ) . Central temperatures , peripheral vasoconstriction , tremor and clonus were unaffected by intravenous lidocaine . We conclude that the systemic absorption of epidural lidocaine does not contribute to tremor or shivering by these mechanisms .
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine :
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Intervention_Control
placebo
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Intervention_Pharmacological
intravenous lidocaine
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Intervention_Control
saline
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
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Outcome_Adverse-effects
shivering-like tremor
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Outcome_Adverse-effects
alter thermoregulation
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Outcome_Physical
.
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Outcome_Adverse-effects
shivering-like tremor seen during epidural anesthesia
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Outcome_Adverse-effects
activates or alters thermoregulatory mechanisms
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Outcome_Physical
.
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Outcome_Adverse-effects
nonthermoregulatory tremor
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Outcome_Physical
)
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Outcome_Other
normal thermoregulation
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Outcome_Physical
)
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Outcome_Physical
Central temperatures , peripheral vasoconstriction , tremor and clonus
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Outcome_Physical
tremor or shivering
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Participant_Condition
major abdominal surgery .