70470
document
Effect of two monophasic oral contraceptives containing gestodene or desogestrel on serum lipoprotein lipid levels . Forty-nine healthy women aged 20-35 years who had not been pregnant or using an oral contraceptive ( OC ) for the previous 3 months were randomized into two groups , one group taking an OC containing 75 micrograms gestodene ( GTD ) and 30 micrograms ethinyl estradiol ( EE ) , and the other group using an OC with 150 micrograms desogestrel ( DSG ) and 30 micrograms EE . Fasting blood samples were taken before treatment , and after cycles 3 and 6 , between the 18th and the 22nd day of the cycle . Blood lipoprotein lipid levels were measured . Serum total cholesterol did not change significantly in both groups . However , in the first three cycles , serum triglyceride increased by 46 % and 40 % and HDL-cholesterol by 14 % and 8 % in the GTD and DSG groups , respectively . The serum LDL level decreased by 6.2 % and 11.8 % , respectively . Between the third and sixth cycle , no further significant changes were observed , nor did these changes differ significantly between the two groups . In conclusion , both OC preparations exerted small and probably favorable effects on serum lipoprotein lipid levels .
70471
Intervention_Pharmacological
monophasic oral contraceptives
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Intervention_Pharmacological
gestodene
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Intervention_Pharmacological
desogestrel
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Intervention_Pharmacological
oral contraceptive ( OC )
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Intervention_Pharmacological
OC
70476
Intervention_Pharmacological
gestodene ( GTD )
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Intervention_Pharmacological
ethinyl estradiol ( EE )
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Intervention_Pharmacological
OC
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Intervention_Pharmacological
desogestrel ( DSG )
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Intervention_Pharmacological
GTD
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Intervention_Pharmacological
DSG
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Intervention_Pharmacological
OC
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Outcome_Physical
Fasting blood samples
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Outcome_Physical
Blood lipoprotein lipid levels
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Outcome_Physical
Serum total cholesterol
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Outcome_Physical
serum triglyceride increased
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Outcome_Physical
HDL-cholesterol
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Outcome_Physical
GTD and DSG
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Outcome_Physical
serum LDL level
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Outcome_Physical
serum lipoprotein lipid levels
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Participant_Sample-size
Forty-nine
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Participant_Sex
women
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Participant_Age
aged 20-35 years
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Participant_Condition
oral contraceptive