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document
Antibiotic prophylaxis in high-risk head and neck surgery : one-day vs. five-day therapy . Patients who undergo major contaminated surgery of the head and neck benefit from perioperative antibiotic prophylaxis . This study was developed to determine if 5 days of antibiotic administration would be more effective than 1 day . A multi-institutional prospective randomized double-blind study was designed . Patients who were identified as requiring pedicled flap reconstruction were potential candidates for the study . Later , patients were randomly assigned to receive cefoperazone sodium for either 24 hours or 120 hours . In each case , the drug was administered intravenously , beginning 1 to 2 hours preoperatively and continued for the prescribed period . One hundred nine patients were evaluable . Fifty-three patients were assigned to 1 day of perioperative prophylaxis . Wound infection developed in ten patients ( 18.9 % ) . Fifty-six patients were assigned to 5 days of perioperative antibiotic prophylaxis . Wound infection developed in 14 ( 25 % ) of these patients ( P greater than .05 ) . These data suggest that no beneficial effect from administration of antibiotics for longer than 24 hours postoperatively can be achieved in patients who undergo myocutaneous flap reconstruction .
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Intervention_Pharmacological
Antibiotic prophylaxis
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Intervention_Pharmacological
one-day
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Intervention_Pharmacological
five-day therapy
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Intervention_Pharmacological
antibiotic prophylaxis
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Intervention_Pharmacological
antibiotic administration
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Intervention_Pharmacological
cefoperazone sodium
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Intervention_Pharmacological
perioperative antibiotic prophylaxis
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Intervention_Pharmacological
antibiotics
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Outcome_Other
antibiotic administration
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Outcome_Physical
Wound infection
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Outcome_Physical
Wound infection
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Participant_Condition
high-risk head and neck surgery
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Participant_Sample-size
One hundred nine