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document
The effect of trandolapril and its fixed-dose combination with verapamil on circulating adhesion molecules levels in hypertensive patients with type 2 diabetes . BACKGROUND AND AIM Endothelial dysfunction in hypertensive type-2 diabetic patients is associated with increased levels of circulating soluble adhesion molecules ( SAM ) . SAM participate in the development of diabetic macroangiopathy and microangiopathy . The aim of this study was to compare the effect of trandolapril ( T ) and its fixed-dose combination with verapamil ( FDTV ) on SAM levels in hypertensive type-2 diabetic patients . METHODS Forty type-2 diabetic patients with never-treated hypertension were randomly assigned to two groups . One group ( FDTV ) received 2/180 mg once a day ; the other group received T 2 mg once a day . Study drugs were administered for three months in both groups . VCAM-1 , ICAM , and E-selectin were measured by ELISA at the beginning and end of the study . Patients were evaluated monthly for blood pressure , fasting serum glucose , and adverse events . Statistical analysis was performed with ANOVA . RESULTS Both therapeutics regimens reduced significantly the levels of the SAM tested . When both groups were compared , we did not find a significant difference in ICAM and E-selectin reduction . However , VCAM-1 presented a significantly greater reduction ( p = 0.022 ) in the trandolapril-verapamil group . No patient suffered adverse events . CONCLUSION Our results show that FDTV produces a greater reduction of VCAM-1 circulating levels than trandolapril alone . This may explain some of the beneficial effects of this fixed dosed combination that are non-related to its antihypertensive effects .
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Intervention_Pharmacological
trandolapril
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Intervention_Pharmacological
verapamil
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Intervention_Pharmacological
trandolapril ( T )
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Intervention_Pharmacological
verapamil ( FDTV )
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Intervention_Pharmacological
( FDTV )
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Intervention_Pharmacological
T
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Intervention_Pharmacological
trandolapril-verapamil
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Outcome_Physical
soluble adhesion molecules ( SAM )
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Outcome_Physical
VCAM-1
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Outcome_Physical
ICAM
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Outcome_Physical
E-selectin
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Outcome_Physical
levels of the SAM tested
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Outcome_Physical
ICAM
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Outcome_Physical
E-selectin reduction
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Outcome_Physical
VCAM-1
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Outcome_Adverse-effects
adverse events .
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Participant_Condition
hypertensive patients with type 2 diabetes
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Participant_Condition
hypertensive type-2 diabetic
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Participant_Condition
hypertensive type-2 diabetic
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Participant_Sample-size
Forty
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Participant_Condition
type-2 diabetic
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Participant_Condition
hypertension