20627
document
Comparative drug effects and abuse liability of lorazepam , buspirone , and secobarbital in nondependent subjects . The pharmacologic effects of lorazepam ( 2 mg ) , buspirone ( 20 mg , 10 mg ) , secobarbital ( 100 mg ) , and placebo were compared in 15 male , experienced , intermittent nontherapeutic drug users . All drugs produced a " drug effect , " however , buspirone 20 mg was significantly less liked than were lorazepam , secobarbital , or buspirone 10 mg ( p less than .05 ) but not placebo . Lorazepam was liked better than were other drugs only at 1 hour and only compared with buspirone 20 and placebo . Compared with other drugs , lorazepam drug effects were greater and resulted in more prolonged impairment of a motor tracking task , standing steadiness , and memory . Buspirone 20 mg significantly impaired memory at 1 hour compared with placebo . Subjects were more likely to identify buspirone as unfamiliar . Because buspirone 20 mg was less liked than were other drugs , dose escalation as part of drug abuse is not likely to occur . Lorazepam also was not particularly liked and was not different from placebo on most subjective abuse-relevant measures .
20628
Intervention_Pharmacological
lorazepam
20629
Intervention_Pharmacological
buspirone
20630
Intervention_Pharmacological
secobarbital
20631
Intervention_Pharmacological
lorazepam
20632
Intervention_Pharmacological
buspirone
20633
Intervention_Pharmacological
secobarbital
20634
Intervention_Control
placebo
20635
Intervention_Pharmacological
buspirone 20
20636
Intervention_Pharmacological
lorazepam
20637
Intervention_Pharmacological
secobarbital
20638
Intervention_Pharmacological
buspirone 10 mg
20639
Intervention_Control
placebo
20640
Intervention_Pharmacological
Lorazepam
20641
Intervention_Pharmacological
buspirone
20642
Intervention_Control
placebo
20643
Intervention_Pharmacological
lorazepam
20644
Intervention_Pharmacological
Buspirone
20645
Intervention_Control
placebo
20646
Intervention_Pharmacological
buspirone
20647
Intervention_Pharmacological
buspirone
20648
Intervention_Pharmacological
Lorazepam
20649
Intervention_Control
placebo
20650
Outcome_Other
drug effects
20651
Outcome_Other
greater
20652
Outcome_Physical
prolonged impairment
20653
Outcome_Physical
motor tracking task , standing steadiness , and
20654
Outcome_Mental
memory
20655
Outcome_Physical
.
20656
Outcome_Physical
significantly
20657
Outcome_Mental
impaired memory
20658
Outcome_Mental
drug abuse
20659
Outcome_Other
not particularly liked
20660
Outcome_Other
not different
20661
Outcome_Mental
most subjective abuse-relevant measures .
20662
Participant_Condition
nondependent subjects
20663
Participant_Sample-size
15
20664
Participant_Condition
experienced , intermittent nontherapeutic drug users