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document
The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample : a Double-Blind , Placebo-Controlled Laboratory Study . Methamphetamine ( MA ) use disorder is a serious psychiatric condition for which there are no FDA-approved medications . Naltrexone ( NTX ) is an opioid receptor antagonist with demonstrated efficacy , albeit moderate , for the treatment of alcoholism and opioid dependence . Preclinical and clinical studies suggest that NTX may be useful for the treatment of MA use disorder . To inform treatment development , we conducted a double-blind , randomized , crossover , placebo-controlled human laboratory study of NTX . Non-treatment-seeking individuals meeting DSM-IV criteria for MA abuse or dependence ( n=30 ) completed two separate 5-day inpatient stays . During each admission , participants completed testing sessions comprised of MA cue-reactivity and intravenous MA administration ( 30 mg ) after receiving oral NTX ( 50 mg ) or placebo for 4 days . This study tested the hypotheses that NTX would ( a ) attenuate cue-induced MA craving , and ( b ) reduce subjective responses to MA administration . Results largely supported the study hypotheses such that ( a ) NTX significantly blunted cue-induced craving for MA and ( b ) attenuated several of the hedonic subjective effects of MA , including craving , during controlled MA administration and as compared with placebo . NTX decreased overall subjective ratings of 'crave drug , ' 'stimulated , ' and 'would like drug access , ' decreased the the post-MA administration timecourse of 'anxious ' and increased ratings of 'bad drug effects , ' as compared with placebo . These findings support a potential mechanism of action by showing that NTX reduced cue-induced craving and subjective responses to MA . This is consistent with positive treatment studies of NTX for amphetamine dependence , as well as ongoing clinical trials for MA .
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Intervention_Pharmacological
Naltrexone
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Intervention_Pharmacological
Methamphetamine
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Intervention_Pharmacological
Methamphetamine
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Intervention_Pharmacological
Naltrexone
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Intervention_Pharmacological
MA
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Outcome_Mental
overall subjective ratings of 'crave drug , ' 'stimulated , ' and 'would like drug access
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Outcome_Mental
timecourse of 'anxious '
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Outcome_Mental
increased ratings of 'bad drug effects
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Outcome_Mental
reduced cue-induced craving and subjective responses to
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Participant_Condition
Methamphetamine ( MA ) use disorder
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Participant_Condition
MA abuse or dependence
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Participant_Sample-size
n=30