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document
[ The effects of antidepressant treatment on efficacy of antihypertensive therapy in elderly hypertension ] . OBJECTIVE To explore the effect of antidepressant treatment on antihypertensive therapy of senile hypertension . METHODS 138 cases of senile hypertension complicating with depression were studied . 103 senile hypertensive patients without depression in the same period served as controls . The patients were randomly divided into 3 groups as A , B and C for study . 12.5 mg/d hydrochlorothiazide and 30 mg/d release-controlling tablets of nifedipine were orally administrated as basic antihypertensive medication each group . Besides , 20 mg/d fluoxetine was additionally given to groups A and one tablet of almitrine l/d and 20 mg oryzanol 3/d were given to group B . The treatment lasted 12 weeks . RESULTS In comparison with pre-treatment , the blood pressure at base line in sitting position and the average circadian SBP and DBP monitored with 24-hour ambulatory blood pressure monitoring ( ABPM ) was remarkably decreased in group A with statistical significance ( P < 0.01 ) . These blood pressure parameters in group B were also decreased as compared ith the pretreatment level brt with less statistical significance ( P > 0.05 ) . It was also noted tha with the addition of antidepressant fluoxetine , the manifestations of depression ere alleviated as shown by Hamilton depression ( HAMD ) scale . untoward reactions such as nausea , perspiration and skin rash were noted in a few patients , but none withdrew from the study . CONCLUSIONS Antidepressant and antianxiety treatment is of benefit to the antihypertensive therapy in senile hypertensive patients with complications of depression and/or anxiety neurosis . Based on the results of this study , it is suggested that routine administration of antidepressants and antianxiety drugs should be carried out in senile hypertensive patients complicating with depression or anxiety .
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Intervention_Pharmacological
antidepressant treatment
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Intervention_Pharmacological
hydrochlorothiazide
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Intervention_Pharmacological
nifedipine
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Intervention_Pharmacological
fluoxetine
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Intervention_Pharmacological
almitrine l/d
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Intervention_Pharmacological
oryzanol 3/d
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Outcome_Other
efficacy
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Outcome_Physical
hypertension
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Outcome_Physical
blood pressure
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Outcome_Physical
average circadian SBP and DBP monitored with 24-hour ambulatory blood pressure monitoring ( ABPM )
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Outcome_Physical
blood pressure parameters
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Outcome_Mental
depression
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Outcome_Mental
Hamilton depression ( HAMD ) scale
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Outcome_Adverse-effects
nausea , perspiration and skin rash
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Participant_Age
elderly
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Participant_Condition
hypertension
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Participant_Condition
senile hypertension
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Participant_Sample-size
138
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Participant_Condition
senile hypertension
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Participant_Condition
depression
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Participant_Sample-size
103
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Participant_Condition
senile hypertensive patients without depression
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Participant_Condition
senile hypertensive patients