76048
document
Treatment of gastrointestinal cancer : the Southeastern Cancer Study Group experience , 1979 to 1983 . The treatment of gastrointestinal cancer was studied in 20 phase I , II , and III clinical trials from 1979 to 1983 at 30 member institutions of the Southeastern Cancer Study Group ( SECSG ) . These studies used both new and commercially available drugs , as well as surgery and/or radiation therapy in 1,087 patients . No significant benefit was seen from 18 agents , and one agent is still under evaluation . Unfortunately , no recommendations can be drawn from these studies that would alter presently accepted methods of management . Adenocarcinoma of the gastrointestinal tract remains a major challenge to tumor biologists and clinical oncologists because it is generally resistant to chemotherapy and radiation therapy , yet common enough to represent a vital public health concern in America .
76049
Intervention_Pharmacological
new and commercially available drugs
76050
Intervention_Surgical
surgery
76051
Intervention_Physical
radiation therapy
76052
Intervention_Other
18 agents
76053
Intervention_Physical
chemotherapy
76054
Intervention_Physical
radiation therapy
76055
Outcome_Physical
gastrointestinal cancer
76056
Outcome_Physical
gastrointestinal cancer