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document
Standard-dose lansoprazole is more effective than high-dose ranitidine in achieving endoscopic healing and symptom relief in patients with moderately severe reflux oesophagitis . The Dutch Lansoprazole Study Group . BACKGROUND In the treatment of reflux oesophagitis , H2-receptor antagonists are still widely used in spite of the apparent higher efficacy of proton pump inhibitors . In an attempt to compensate for the lower efficacy , H2-receptor antagonists are now increasingly being used at a higher dose . OBJECTIVE To assess whether or not standard-dose lansoprazole ( 30 mg o.d . ) is more effective than high-dose ranitidine ( 300 mg b.d . ) in moderately severe reflux oesophagitis ( grades II-III ) . METHODS Lansoprazole or ranitidine was given to 133 patients for 4-8 weeks in a double-blind , randomized , parallel group , multicentre trial . RESULTS The percentage of patients with endoscopically-verified healing was significantly higher on lansoprazole than on ranitidine both after 4 weeks ( 79 % vs. 42 % ) and 8 weeks ( 91 % vs. 66 % ) , though smoking had a negative impact on oesophagitis healing with lansoprazole . Heartburn , retrosternal pain and belching improved significantly better with lansoprazole than with ranitidine , as did the patient-rated overall symptom severity . Relief of heartburn appeared somewhat faster with ranitidine , but was more pronounced with lansoprazole . The number of patients with adverse events was similar in both treatment groups . CONCLUSION Standard-dose lansoprazole is better than high-dose ranitidine in moderately severe reflux oesophagitis .
2204
Intervention_Pharmacological
Standard-dose lansoprazole
2205
Intervention_Pharmacological
high-dose ranitidine
2206
Intervention_Pharmacological
Lansoprazole
2207
Intervention_Pharmacological
standard-dose lansoprazole
2208
Intervention_Pharmacological
high-dose ranitidine
2209
Intervention_Pharmacological
Lansoprazole
2210
Intervention_Pharmacological
ranitidine
2211
Intervention_Pharmacological
lansoprazole
2212
Intervention_Pharmacological
ranitidine
2213
Intervention_Pharmacological
lansoprazole
2214
Intervention_Pharmacological
lansoprazole
2215
Intervention_Pharmacological
ranitidine
2216
Intervention_Pharmacological
ranitidine
2217
Intervention_Pharmacological
lansoprazole
2218
Intervention_Pharmacological
Standard-dose lansoprazole
2219
Intervention_Pharmacological
high-dose ranitidine
2220
Outcome_Physical
percentage of patients with endoscopically-verified healing
2221
Outcome_Physical
Heartburn , retrosternal pain and belching
2222
Outcome_Physical
Relief of heartburn
2223
Outcome_Adverse-effects
number of patients with adverse events
2224
Participant_Condition
reflux oesophagitis
2225
Participant_Sample-size
133