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document
Ursodeoxycholic acid has no influence on function after restorative proctocolectomy in ulcerative colitis . BACKGROUND Poor pouch function is associated with impaired bile acid absorption and increased faecal loss of bile acids . Bile acid replacement therapy might therefore be of clinical benefit , provided that diarrhoea is not aggravated by therapy . AIM To investigate the role of exogenous bile acid therapy in patients with poor pouch function after restorative proctocolectomy for ulcerative colitis . PATIENTS AND METHODS Twenty ulcerative colitis patients with poor pouch function ( score > 4 on a 12-point score ) were recruited for inclusion to a prospective , randomized , double-blind crossover , placebo-controlled trial of ursodeoxycholic acid ( 10 mg/kg per day in two divided doses for 1 month ) . RESULTS A total of 16 patients completed the study . There was no significant difference in the functional score or bowel frequency following treatment irrespective of whether the active treatment was given before or after placebo . CONCLUSIONS We conclude that ursodeoxycholic acid given over 4 weeks had no influence on functional score or bowel frequency after restorative proctocolectomy for U.C .
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Intervention_Pharmacological
Ursodeoxycholic acid
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Intervention_Pharmacological
Bile acid replacement therapy
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Intervention_Pharmacological
exogenous bile acid therapy
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
ursodeoxycholic acid
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Intervention_Pharmacological
ursodeoxycholic acid
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Outcome_Physical
proctocolectomy
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Outcome_Physical
functional score or bowel frequency
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Outcome_Physical
functional score or bowel frequency
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Outcome_Physical
U.C .
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Participant_Condition
ulcerative colitis
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Participant_Condition
patients with poor pouch function
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Participant_Sample-size
Twenty
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Participant_Condition
ulcerative colitis
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Participant_Condition
poor pouch function
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Participant_Sample-size
16