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document
Enhancing antiepileptic drug adherence : a randomized controlled trial . Suboptimal adherence to antiepileptic drug ( AED ) treatment is commonplace , and increases the risk of status epilepticus and sudden unexplained death in epilepsy . This randomized controlled trial was designed to demonstrate whether an implementation intention intervention involving the completion of a simple self-administered questionnaire linking the intention of taking medication with a particular time , place , and other activity can improve AED treatment schedule adherence . Of the 81 patients with epilepsy who were randomized , 69 completed a 1-month monitoring period with an objective measure of tablet taking ( electronic registration of pill bottle openings , Medication Event Monitoring System [ MEMS ] ) . Intervention participants showed improved adherence relative to controls on all three outcomes : doses taken in total ( 93.4 % vs. 79.1 % ) , days on which correct dose was taken ( 88.7 % vs. 65.3 % ) , and doses taken on schedule ( 78.8 % vs. 55.3 % ) ( P < 0.01 ) . The implementation intention intervention may be an easy-to-administer and effective means of promoting AED adherence .
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Intervention_Pharmacological
antiepileptic drug
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Intervention_Pharmacological
antiepileptic drug ( AED ) treatment
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Intervention_Educational
self-administered questionnaire
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Intervention_Pharmacological
AED
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Intervention_Pharmacological
intention intervention
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Intervention_Pharmacological
AED
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Outcome_Mental
improved adherence relative to controls
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Outcome_Other
doses taken in total
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Outcome_Other
correct dose was taken
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Outcome_Other
doses taken on schedule