85766
document
Torasemide in the treatment of patients with cirrhosis and ascites . The effects of torasemide ( 20 mg/day ) and furosemide ( 50 mg/day ) , each given over 4 days , were compared in a randomized and crossover study carried out in seven patients with cirrhosis and tense ascites . Patients also received a low-sodium ( 40 mmol/day ) diet and the aldosterone antagonist , potassium canrenoate ( 100 mg b.i.d. ) . Torasemide induced a remarkably higher natriuretic ( 120 +/- 15 vs. 33 +/- 6 mmol/day , p < 0.02 ) and diuretic ( 1450 +/- 63 vs. 900 +/- 58 ml , p < 0.005 ) effect than furosemide . Body weight loss was also significantly higher ( 2.5 +/- 1.6 vs. 0.2 +/- 1.3 kg , p < 0.01 ) during the torasemide period . Kaliuresis was similar during the two treatment periods , despite the striking differences observed in natriuresis . Neither torasemide nor furosemide induced any significant change in serum electrolyte or creatinine concentrations , or in ammonia levels . The results of this study indicate that torasemide is suitable for the treatment of sodium retention in patients with cirrhosis and ascites .
85767
Intervention_Pharmacological
Torasemide
85768
Intervention_Pharmacological
torasemide ( 20 mg/day )
85769
Intervention_Pharmacological
furosemide ( 50 mg/day )
85770
Intervention_Pharmacological
low-sodium ( 40 mmol/day ) diet
85771
Intervention_Pharmacological
aldosterone antagonist
85772
Intervention_Pharmacological
potassium canrenoate
85773
Intervention_Pharmacological
Torasemide
85774
Intervention_Pharmacological
furosemide
85775
Intervention_Pharmacological
torasemide
85776
Intervention_Pharmacological
torasemide
85777
Intervention_Pharmacological
furosemide
85778
Intervention_Pharmacological
torasemide
85779
Outcome_Physical
natriuretic
85780
Outcome_Physical
diuretic
85781
Outcome_Physical
Body weight loss
85782
Outcome_Physical
Kaliuresis
85783
Outcome_Physical
serum electrolyte or creatinine concentrations , or in ammonia levels .
85784
Participant_Condition
cirrhosis and ascites
85785
Participant_Sample-size
seven
85786
Participant_Condition
cirrhosis and tense ascites
85787
Participant_Condition
cirrhosis and ascites