79020
document
Comparison of tocainide and prajmalium bitartrate for the treatment of ventricular arrhythmias . The antiarrhythmic efficacy of tocainide , a new antiarrhythmic substance , has been compared with that of prajmalium bitartrate , a drug in clinical use for many years in the German speaking countries . The investigation was performed as a double-blind cross-over study in 20 patients with ventricular arrhythmias ( VA ) of various origin . The efficacy was assessed by serial Holter monitoring . Plasma levels were measured to study the dose-effect relationship . Applying to the criterion of a reduction of VA of more than 75 % or an improvement according to the Lown grading 8 pts . under tocainide and 7 under prajmalium bitartrate were responders . Side effects were few and under tocainide only 2 pts . had to discontinue the therapy . From the present findings tocainide and prajmalium bitartrate have the same efficient antiarrhythmic effects in the majority of patients .
79021
Intervention_Pharmacological
tocainide
79022
Intervention_Pharmacological
prajmalium bitartrate
79023
Intervention_Pharmacological
tocainide
79024
Intervention_Pharmacological
prajmalium bitartrate
79025
Intervention_Pharmacological
prajmalium bitartrate
79026
Intervention_Pharmacological
tocainide
79027
Intervention_Pharmacological
prajmalium bitartrate
79028
Outcome_Other
efficacy
79029
Outcome_Other
Holter monitoring .
79030
Outcome_Physical
Plasma levels
79031
Outcome_Physical
reduction of VA
79032
Outcome_Physical
Lown grading
79033
Outcome_Adverse-effects
Side effects
79034
Outcome_Other
antiarrhythmic effects
79035
Participant_Condition
ventricular arrhythmias
79036
Participant_Sample-size
20
79037
Participant_Condition
ventricular arrhythmias
79038
Participant_Condition
VA