73046
document
Influence of ibopamine on heart rate and arrhythmic pattern in patients with congestive heart failure . A double-blind multicentre study . Ibopamine is a dopaminergic and adrenergic receptor agonist , which is active in the treatment of congestive heart failure . Since the long-term prognosis for patients with congestive heart failure remains very poor and the incidence of arrhythmic death is high , every new drug to be employed against this disease should be thoroughly tested in order to rule out any possible arrhythmogenic action . This multicentre study was designed to evaluate the effect of ibopamine versus placebo in double-blind conditions on heart rate , rhythm and electrical safety . Ibopamine was employed at a dose of 100 mg t.i.d . in 97 patients ( aged 31-83 years ) belonging to NYHA class II and III with congestive heart failure of different aetiology , but without any complex ventricular arrhythmias in basal conditions ( couplets with R'-R " less than or equal to 400 msec , ventricular tachycardia , R on T phenomena ) . Using a random cross-over design the patients were submitted to 48 hr . Holter recordings in basal conditions and following 7 days of ibopamine and placebo treatment . No influence on heart rhythm was noted . No significant variations in maximum heart rate ( ibopamine 117.7 +/- 20.9 ; placebo 118.1 +/- 20.7 ) , medium heart rate ( ibopamine 71.8 +/- 10.2 ; placebo 72.6 +/- 10.1 ) or minimum heart rate ( ibopamine 55.3 +/- 11.7 ; placebo 54.6 +/- 10.6 ) were observed . The mean number/hr . of ectopic supraventricular beats was 26.1 +/- 61.9 after ibopamine and 21.7 +/- 35.8 after placebo ( p = ns ) . The complexity of ectopic supraventricular beats did not change . The mean number/hr . of ectopic ventricular beats was 31.1 +/- 52.5 after ibopamine and 30.4 +/- 57.8 after placebo ( p = ns ) . Neither the distribution of the patients among Lown classification nor the Final Score of the Italian Lown Classification ( 26.1 +/- 18.0 and 26.6 +/- 17.9 in the 1st and 2nd day of monitoring after ibopamine and 25.7 +/- 18.6 and 25.7 +/- 18.8 after placebo ; p = ns ) showed any difference between active treatment and placebo . Similar results were achieved when the patients were sub-divided into subgroups according to sequences of treatment ( basal -- -- ibopamine -- -- placebo and basal -- -- placebo -- -- ibopamine ) , NYHA class II or III , aetiology of congestive heart failure ( dilatative cardiomyopathy , ischemic cardiomyopathy and other aetiologies ) , associated treatment with digitalis or diuretics and the number and complexity of base ectopic ventricular beats . None of the patients experienced sustained ventricular tachycardia . ( ABSTRACT TRUNCATED AT 400 WORDS )
73047
Intervention_Pharmacological
ibopamine
73048
Intervention_Pharmacological
Ibopamine
73049
Intervention_Pharmacological
ibopamine
73050
Intervention_Control
placebo
73051
Intervention_Pharmacological
Ibopamine was employed at a dose of 100 mg t.i.d .
73052
Intervention_Physical
in 97 patients ( aged 31-83 years ) belonging to NYHA class II and III with congestive heart failure of different aetiology
73053
Intervention_Physical
but without any complex ventricular arrhythmias in basal conditions ( couplets with R'-R " less than or equal to 400 msec , ventricular tachycardia
73054
Intervention_Other
R on T phenomena
73055
Intervention_Pharmacological
Holter recordings in basal conditions and following 7 days of ibopamine
73056
Outcome_Physical
heart rate and arrhythmic pattern
73057
Outcome_Physical
arrhythmogenic action
73058
Outcome_Physical
heart rate , rhythm and
73059
Outcome_Other
electrical safety
73060
Outcome_Other
Holter recordings
73061
Outcome_Physical
heart rhythm
73062
Outcome_Physical
maximum heart rate
73063
Outcome_Physical
medium heart rate
73064
Outcome_Physical
minimum heart rate
73065
Outcome_Physical
ectopic supraventricular beats
73066
Outcome_Physical
ectopic supraventricular beats
73067
Outcome_Physical
ectopic ventricular beats
73068
Outcome_Physical
Lown classification nor the Final Score of the Italian Lown Classification
73069
Participant_Condition
patients with congestive heart failure .