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[ Evaluation on the effect of intervention regarding breast self-examination for decreasing breast cancer mortality ] . OBJECTIVE A randomized trial of breast self-examination ( BSE ) Program was carried out to evaluate whether the intensive BSE could reduce the number of deaths among women from breast cancer . METHODS This study was a randomized controlled trial ( RCT ) . A total of 266 064 women ( age of 30 to 64 years ) associated with 519 textile factories in Shanghai had been randomly assigned to a BSE group ( 132 979 women ) or a control group ( 133 085 women ) since 1989 . Initial instruction in BSE group would include demonstration of proper palpation techniques and was followed by 2 reinforcement sessions during the subsequent 4 years including video shows , BSE instruction sessions and BSE practice under medical supervision . These activities were continued for 5 years . Attendance at all events was recorded . The cohort was followed through July 2000 for development of breast diseases , and the breast cancer cases were followed through 2001 for vital status . Data analysis methods used would include Kaplan-Meier plots , log-rank test and Cox modeling . RESULTS Among women under instruction , 864 breast cancers detected and 133 breast cancer deaths occurred while 896 breast cancers were detected and 130 deaths recorded in the control group . The tumor size ( P = 0.07 ) , TNM stage ( P = 0.39 ) and cumulative breast cancer mortality rate ( P = 0.72 ) were not significantly different between the 2 groups . However , more and smaller fibroadenomas were detected in the instruction group than in the control group ( P < 0.01 ) . CONCLUSION Intensive instruction in BSE did not seem to have reduced the mortality rate of breast cancer , but more and smaller benign breast lumps could be detected .
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Intervention_Educational
breast self-examination ( BSE ) Program
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Intervention_Educational
BSE
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Intervention_Educational
BSE
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Intervention_Control
control
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Intervention_Educational
BSE
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Intervention_Educational
BSE
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Outcome_Mortality
breast cancer mortality rate
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Outcome_Mortality
mortality rate of breast cancer
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Outcome_Other
more and smaller benign breast lumps could be detected