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document
Losartan vs. amlodipine treatment in elderly oncologic hypertensive patients : a randomized clinical trial . Elderly neoplastic patients frequently may show hypertension and hyperuricemia , before and after chemotherapeutic treatments . The purpose of this study was to evaluate the efficacy of losartan which is an antihypertensive drug with uricosuric properties vs. amlodipine in hypertensive neoplastic elderly patients . This was an open-labeled , randomized , comparative trial . The study was performed as a 30-day study . Seventy patients with cancer were randomly assigned to receive losartan or amlodipine . Blood pressure ( BP ) , blood urea nitrogen ( BUN ) levels , creatinine , serum and urinary uric acid , creatinine and uric acid clearance were determined before and after chemotherapy . One day after chemotherapy in losartan group vs. amlodipine group we observed a significant difference in urinary uric acid ( p < 0.001 ) of 18 mg/24 h vs. 40 mg/24 h. Thirty days after chemotherapy we observed a significant difference in azotemia of 0.0 mg/dl vs. 3.8 mg/dl ( p < 0.001 ) , serum uric acid of 0.05 mg/dl vs. 0.49 mg/dl ( p < 0.001 ) , urinary uric acid ( p < 0.001 ) of 23 mg/24 h vs. 0.0 mg/24 h , GFR of 2 ml/min/1.73 m ( 2 ) vs. -8 ml/min/1.73 m ( 2 ) ( p < 0.05 ) and systolic BP ( SBP ) of 3.6 mmHg vs. 0.8 mmHg ( p < 0.05 ) . The findings of the present study support the effective role of losartan compared to amlodipine in treating hypertension and hyperuricemia in elderly patients under chemotherapeutic treatment .
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Intervention_Pharmacological
Losartan vs. amlodipine
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Intervention_Pharmacological
losartan
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Intervention_Pharmacological
antihypertensive drug
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Intervention_Pharmacological
uricosuric
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Intervention_Pharmacological
amlodipine
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Intervention_Pharmacological
losartan or amlodipine .
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Intervention_Pharmacological
chemotherapy
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Intervention_Pharmacological
losartan
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Intervention_Pharmacological
amlodipine
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Intervention_Pharmacological
chemotherapy
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Intervention_Pharmacological
losartan
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Intervention_Pharmacological
amlodipine
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Outcome_Physical
Blood pressure
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Outcome_Physical
blood urea nitrogen ( BUN ) levels
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Outcome_Physical
creatinine
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Outcome_Physical
serum and urinary uric acid
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Outcome_Physical
creatinine and uric acid clearance
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Outcome_Physical
urinary uric acid
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Outcome_Physical
azotemia
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Outcome_Physical
serum uric acid
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Outcome_Physical
urinary uric acid
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Outcome_Physical
systolic BP
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Participant_Age
elderly
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Participant_Condition
oncologic hypertensive
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Participant_Condition
neoplastic
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Participant_Condition
hypertension
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Participant_Condition
hyperuricemia
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Participant_Condition
hypertensive neoplastic
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Participant_Age
elderly
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Participant_Sample-size
Seventy
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Participant_Condition
cancer
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Participant_Condition
hypertension
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Participant_Condition
hyperuricemia
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Participant_Condition
chemotherapeutic treatment