83824
document
A comparison of albuterol solution nebulized versus albuterol powder given by breath activated metered dose inhaler . The goal of the present study was to compare the efficacy of nebulized vs powdered albuterol in patients with exacerbated bronchial asthma who required hospitalization . From January to May 1990 known asthmatics admitted with acute exacerbation were included by established criteria . Two groups were randomized . Group I for Albuterol powder 200 micrograms inhaled q 4 hours . Group II with Albuterol nebulized solution 2.5 mg inhaled q 4 hrs . Force Vital Capacity and Force Expiratory Volume in one second were measured with a pressure differential transducer upon admission , 30 minutes and 24-hours following therapies . Absolute FEV1 improvement was calculated . Statistical analysis was performed using student 's T-Test and Fisher 's exact Test with significance established at p > 0.01 % . Fifteen patients enrolled in both groups , two patients of group I were excluded from the statistic analysis due to refusal to continue with the therapy . Both groups were comparable with respect to sex , asthma exacerbations/year , smoking history and hospital length of stay . FVC and FEV1 were comparable also . In contrast , there were significant difference when the absolute improvement were compared . The mean +/- SE for FEV1 absolute improvement at the first 30 min was 0.42 +/- 0.08 lts for the Group I versus 0.65 +/- 0.6 lts in the Group II . In the next 24 hours , Group I was 0.16 +/- 0.2 lts versus 0.30 +/- 0.7 lts in Group II ( p > .01 ) . We conclude that although the dose equivalence of both delivery systems have not been established in our study , the nebulized solution was more effective during the first 24 hours of hospitalization than the dry powder .
83825
Intervention_Pharmacological
albuterol solution nebulized
83826
Intervention_Pharmacological
albuterol powder
83827
Intervention_Pharmacological
nebulized
83828
Intervention_Pharmacological
powdered albuterol
83829
Intervention_Pharmacological
Albuterol powder
83830
Intervention_Pharmacological
Albuterol nebulized solution
83831
Intervention_Pharmacological
nebulized solution
83832
Intervention_Pharmacological
dry powder
83833
Outcome_Physical
Force Vital Capacity and Force Expiratory Volume
83834
Outcome_Physical
Absolute FEV1 improvement
83835
Outcome_Physical
FVC and FEV1
83836
Outcome_Physical
mean +/- SE for FEV1
83837
Participant_Condition
exacerbated bronchial asthma who required hospitalization
83838
Participant_Condition
From January to May 1990
83839
Participant_Condition
acute exacerbation
83840
Participant_Sample-size
Fifteen