20396
document
Immunogenicity and reactogenicity of two regimens of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio and Haemophilus influenzae type b vaccines administered to infants primed at birth with hepatitis B vaccine . An open , randomized study evaluated the immune response and safety of two different regimens of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b ( DTPa-HBV-IPV-Hib ) immunization in infants primed at birth with hepatitis B vaccine . One-half of the 150 healthy , full-term infants received a DTPa HBV-IPV-Hib vaccine at 1 1/2 , 3 and 5 months of age ; the other received a DTPa-IPV-Hib vaccine at 1 1/2 , 3 and 5 months of age with separate HBV vaccine at 1 and 5 months of age . Immune response was similar following the two regimens with 100 % of the vaccinees seroprotected for HBV , diphtheria , tetanus , Hib and poliovirus types 2 and 3 diseases after the full vaccination course . One vaccinee in the DTPa HBV-HPV- Hib group failed to respond to the poliovirus type 1 antigen . Response to the three pertussis antigens ranged from 92-97 % in the DTPa-IPV-Hib plus separate HBV group and 100 % in the DTPa HBV-IPV-Hib group . The most frequently reported post-vaccination symptoms were irritability in the DTPa-IPV-Hib plus separate HBV group ( 49 % of vaccinees ) and fever , defined as axillary temperature > or =37.5 degrees C , in the DTPa HBV- IPV-Hib group ( 50 % of vaccinees ) .
20397
Intervention_Pharmacological
type b vaccines administered
20398
Intervention_Pharmacological
diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b ( DTPa-HBV-IPV-Hib )
20399
Intervention_Pharmacological
DTPa HBV-IPV-Hib vaccine
20400
Intervention_Pharmacological
DTPa-IPV-Hib
20401
Intervention_Pharmacological
HBV vaccine
20402
Outcome_Physical
Immunogenicity
20403
Outcome_Physical
reactogenicity
20404
Outcome_Physical
immune response
20405
Outcome_Physical
safety
20406
Outcome_Physical
Response
20407
Outcome_Adverse-effects
irritability
20408
Outcome_Adverse-effects
fever
20409
Participant_Age
infants
20410
Participant_Condition
hepatitis B
20411
Participant_Age
infants
20412
Participant_Condition
hepatitis B
20413
Participant_Sample-size
150
20414
Participant_Age
infants