84608
document
Erythrocyte deformability , endothelin levels , and renal function in cyclosporin-treated renal transplant recipients : effects of intervention with fish oil and corn oil . Twenty nine stable renal transplant recipients , 10 receiving cyclosporin , 10 cyclosporin-prednisolone and nine azathioprine-prednisolone were supplemented in a double blind randomization cross-over study with fish oil and corn oil for a period of 4 months each . Erythrocyte deformability was reduced in the cyclosporin-treated patients and returned to normal values after supplementation of either oil . The oil supplementation resulted in an increased polyunsaturated fatty acid content in the plasma phospholipids . An increased erythrocyte membrane polyunsaturated fatty acid content might correct the lower erythrocyte deformability in cyclosporin treated patients . Therefore , it is probable that these changes are membrane-related . The oil supplementation had no effect on glomerular filtration rate , effective renal plasma flow , filtration fraction or blood pressure , which does not exclude effects of the cyclosporin-induced rigidified erythrocytes in the acute phase of renal transplantation . Decreased erythrocyte deformability could play a role in the cyclosporin-induced deterioration of renal haemodynamics . This may enhance the effects of endothelin , as these patients also had elevated endothelin levels .
84609
Intervention_Pharmacological
cyclosporin-treated
84610
Intervention_Pharmacological
fish oil
84611
Intervention_Pharmacological
corn oil
84612
Intervention_Pharmacological
cyclosporin
84613
Intervention_Pharmacological
10 cyclosporin-prednisolone
84614
Intervention_Pharmacological
azathioprine-prednisolone
84615
Intervention_Pharmacological
fish oil
84616
Intervention_Pharmacological
corn oil
84617
Intervention_Pharmacological
cyclosporin-treated
84618
Intervention_Pharmacological
oil
84619
Intervention_Pharmacological
cyclosporin
84620
Intervention_Pharmacological
oil
84621
Intervention_Pharmacological
cyclosporin-induced
84622
Outcome_Physical
Erythrocyte deformability
84623
Outcome_Physical
endothelin levels
84624
Outcome_Physical
renal function
84625
Outcome_Physical
Erythrocyte deformability
84626
Outcome_Physical
polyunsaturated fatty acid content
84627
Outcome_Physical
glomerular filtration rate
84628
Outcome_Physical
effective renal plasma flow
84629
Outcome_Physical
filtration fraction or blood pressure
84630
Outcome_Physical
erythrocyte deformability
84631
Participant_Condition
cyclosporin-treated renal transplant recipients :
84632
Participant_Sample-size
Twenty nine
84633
Participant_Condition
stable renal transplant recipients
84634
Participant_Sample-size
10
84635
Participant_Sample-size
10
84636
Participant_Sample-size
nine