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document
Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic activity . Large individual differences characterize the changes induced by sleep deprivation on neurobehavioral functions and rhythmic brain activity . To investigate adenosinergic mechanisms in these differences , we studied the effects of prolonged waking and the adenosine receptor antagonist caffeine on sustained vigilant attention and regional electroencephalogram ( EEG ) power in the ranges of theta activity ( 6.25-8.25 Hz ) in waking and the slow oscillation ( < 1 Hz ) in sleep . Activity in these frequencies is functionally related to sleep deprivation . In 12 subjectively caffeine-sensitive and 10 -insensitive young men , psychomotor vigilance task ( PVT ) performance and EEG were assessed at 3 h intervals before , during , and after one night without sleep . After 11 and 23 h waking , subjects received 200 mg caffeine and placebo in double-blind , cross-over manner . In the placebo condition , sleep deprivation impaired PVT speed more in caffeine-sensitive than in caffeine-insensitive men . This difference was counteracted by caffeine . Theta power in waking increased more in a frontal EEG derivation than in a posterior derivation . Caffeine attenuated this power gradient in caffeine sensitive subjects . Sleep loss also differently affected the power distribution < 1 Hz in non-rapid eye movement sleep between caffeine sensitive and insensitive subjects . Also , this difference was mirrored by the action of caffeine . The effects of sleep deprivation and caffeine on sustained attention and regional EEG power in waking and sleep were inversely related . These findings suggest that adenosinergic mechanisms contribute to individual differences in waking-induced impairment of neurobehavioral performance and functional aspects of EEG topography associated with sleep deprivation .
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Intervention_Physical
Adenosinergic mechanisms
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Intervention_Physical
adenosinergic mechanisms
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Intervention_Pharmacological
caffeine
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Intervention_Physical
one night without sleep
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Intervention_Pharmacological
caffeine
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Intervention_Control
placebo
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Intervention_Control
placebo
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Intervention_Pharmacological
caffeine
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Intervention_Pharmacological
Caffeine
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Intervention_Pharmacological
caffeine
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Intervention_Pharmacological
caffeine
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Intervention_Physical
adenosinergic mechanisms
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Outcome_Physical
Theta power in waking
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Outcome_Physical
Sleep loss
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Outcome_Physical
non-rapid eye movement sleep
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Outcome_Physical
sleep deprivation
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Outcome_Physical
waking and sleep
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Outcome_Physical
waking-induced impairment of neurobehavioral performance
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Participant_Condition
individual differences in sleep deprivation-induced
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Participant_Sample-size
12
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Participant_Sample-size
10
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Participant_Age
young
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Participant_Sex
men