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document
Randomised controlled study of clinical outcome following trophic feeding . AIMS To determine the effect of trophic feeding on clinical outcome in ill preterm infants . METHODS A randomised , controlled , prospective study of 100 preterm infants , weighing less than 1750 g at birth and requiring ventilatory support and parenteral nutrition , was performed . Group TF ( 48 infants ) received trophic feeding from day 3 ( 0.5-1 ml/h ) along with parenteral nutrition until ventilatory support finished . Group C ( 52 infants ) received parenteral nutrition alone . " Nutritive " milk feeding was then introduced to both groups . Clinical outcomes measured included total energy intake and growth over the first six postnatal weeks , sepsis incidence , liver function , milk tolerance , duration of respiratory support , duration of hospital stay and complication incidence . RESULTS Groups were well matched for birthweight , gestation and CRIB scores . Infants in group TF had significantly greater energy intake , mean difference 41.4 ( 95 % confidence interval 9 , 73.7 ) kcal/kg p=0.02 ; weight gain , 130 ( CI 1 , 250 ) g p = 0.02 ; head circumference gain , mean difference 0.7 ( CI 0.1 , 1.3 ) cm , p = 0.04 ; fewer episodes of culture confirmed sepsis , mean difference -0.7 ( -1.3 , -0.2 ) episodes , p = 0.04 ; less parenteral nutrition , mean difference -11.5 ( CI -20 , -3 ) days , p = 0 . 03 ; tolerated full milk feeds ( 165 ml/kg/day ) earlier , mean difference -11.2 ( CI -19 , -3 ) days , p = 0.03 ; reduced requirement for supplemental oxygen , mean difference -22.4 ( CI-41.5 , -3.3 ) days , p = 0.02 ; and were discharged home earlier , mean difference -22.1 ( CI -42.1 , -2.2 ) days , p = 0.04 . There was no significant difference in the relative risk of any complication . CONCLUSIONS Trophic feeding improves clinical outcome in ill preterm infants requiring parenteral nutrition .
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Intervention_Pharmacological
trophic feeding .
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Intervention_Pharmacological
trophic feeding
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Intervention_Pharmacological
trophic feeding from day 3 ( 0.5-1 ml/h ) along with parenteral nutrition
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Intervention_Physical
ventilatory support
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Intervention_Pharmacological
parenteral nutrition alone . " Nutritive " milk feeding
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Intervention_Pharmacological
Trophic feeding
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Intervention_Pharmacological
parenteral nutrition .
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Outcome_Physical
energy intake and growth over the first six postnatal weeks
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Outcome_Physical
sepsis incidence
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Outcome_Physical
liver function
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Outcome_Physical
milk tolerance
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Outcome_Other
duration of respiratory support
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Outcome_Other
duration of hospital stay
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Outcome_Adverse-effects
complication incidence
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Outcome_Physical
energy intake
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Outcome_Physical
weight gain
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Outcome_Physical
head circumference gain
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Outcome_Physical
episodes of culture confirmed sepsis
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Outcome_Other
parenteral nutrition
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Outcome_Physical
tolerated full milk feeds
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Outcome_Other
requirement for supplemental oxygen
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Outcome_Other
discharged
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Outcome_Adverse-effects
risk of any complication
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Participant_Condition
ill preterm
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Participant_Age
infants
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Participant_Sample-size
100