75781
document
The effect of metronidazole on the incidence of postoperative wound infection in elective colon surgery . A prospective randomized clinical trial assessing the relative effectiveness of erythromycin-neomycin and metronidazole-neomycin as a preoperative bowel preparation was carried out . Bacteriologic studies of feces and colon content revealed no significant difference in the reduction of aerobic bacteria between the two groups . There was , however , a significantly greater reduction in anaerobic bacteria in the feces and colon contents of patients receiving metronidazole . Wound infection rate was 25 % in the erythromycin group , and organisms recovered from the wound in all cases were fecal in nature . Two wound infections occurred in the metronidazole group ( 5 % ) and in both cases the organisms recovered were staphylococci of presumed skin origin . These studies suggest that anaerobic bacteria are the major contributors to wound infection after colon surgery and that their specific reduction is associated with a lower incidence of wound infection .
75782
Intervention_Pharmacological
metronidazole
75783
Intervention_Pharmacological
erythromycin-neomycin
75784
Intervention_Pharmacological
metronidazole-neomycin
75785
Outcome_Physical
incidence of postoperative wound infection
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Outcome_Physical
reduction of aerobic bacteria
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Outcome_Physical
reduction
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Outcome_Physical
anaerobic bacteria
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Outcome_Physical
Wound infection rate
75790
Participant_Condition
postoperative wound infection in elective colon surgery .