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document
Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial . Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies . Using logistic regression , we estimated odds ratios ( ORs ) and 95 % confidence intervals ( CIs ) to prospectively evaluate the association between lignan and proanthocyanidin intake , estimated from databases linked to a food frequency questionnaire , and adenoma recurrence in 1,859 participants of the Polyp Prevention Trial . Overall , individual or total lignans or proanthocyanidins were not associated with colorectal adenoma recurrence . However , in sex-specific analyses , total lignan intake was positively associated with any adenoma recurrence in women ( highest vs. lowest lignan intake quartile OR = 2.07 , 95 % CI : 1.22-3.52 , p trend = 0.004 ) but not in men ( p interaction = 0.04 ) . To conclude , dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence ; however , high lignan intake may increase the risk of adenoma recurrence in women .
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Intervention_Pharmacological
Dietary lignan
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Intervention_Pharmacological
proanthocyanidin
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Intervention_Pharmacological
polyphenols
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Intervention_Pharmacological
lignan
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Intervention_Pharmacological
proanthocyanidin intake
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Outcome_Physical
colorectal adenoma recurrence
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Outcome_Physical
colorectal neoplasms
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Outcome_Physical
adenoma recurrence
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Outcome_Physical
colorectal adenoma recurrence
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Outcome_Physical
adenoma recurrence
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Outcome_Physical
colorectal adenoma recurrence
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Outcome_Physical
risk of adenoma recurrence
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Participant_Condition
colorectal adenoma recurrence
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Participant_Condition
colorectal neoplasms
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Participant_Sex
women .