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document
Comparison of gonadotropin-releasing hormone agonists and antagonists in assisted reproduction cycles of polycystic ovarian syndrome patients . AIM Gonadotropin-releasing hormone ( GnRH ) antagonists have reduced the incidence of severe ovarian hyper stimulation syndrome ( OHSS ) and rate of hospitalization due to severe OHSS , especially in polycystic ovarian syndrome ( PCOS ) patients . The present study aimed to compare the outcomes of patients with PCOS undergoing controlled ovarian hyperstimulation ( COH ) with GnRH agonist versus GnRH antagonist protocols for assisted reproduction cycles . METHODS The present clinical trial compared GnRH antagonist ( cetrorelix ) and GnRH agonist ( buserelin ) protocols during COH of 112 infertile PCOS patients entering assisted reproduction cycles . The primary outcome measure was pregnancy occurrence . Basal characteristics of the participants , stimulation cycle responses , pregnancy outcomes , incidence of OHSS and types of OHSS were considered in both groups . RESULTS Regarding chemical and clinical pregnancy rates , the number of retrieved oocytes was significantly higher and OHSS was significantly lower in the antagonist group . Follicle stimulating hormone ( FSH ) , luteinizing hormone ( LH ) levels , number of follicles , number of follicles > 18 mm , relative frequency of mature oocytes , number and days of gonadotropin injections , day of human chorionic gonadotropin ( HCG ) administration , estradiol level and abortion were similar between the two groups . CONCLUSION GnRH antagonists are more effective , safe and a well tolerated alternative to agonists for assisted reproduction cycles in PCOS patients . GnRH antagonists are associated with a reduction in the incidence of OHSS in these patients .
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Intervention_Pharmacological
gonadotropin-releasing hormone agonists
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Intervention_Pharmacological
antagonists
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Intervention_Pharmacological
GnRH agonist
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Intervention_Physical
GnRH antagonist
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Intervention_Pharmacological
GnRH antagonist ( cetrorelix )
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Intervention_Pharmacological
GnRH agonist ( buserelin )
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Outcome_Physical
pregnancy occurrence .
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Outcome_Physical
stimulation cycle responses
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Outcome_Physical
pregnancy outcomes
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Outcome_Physical
incidence of OHSS
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Outcome_Physical
types of OHSS
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Outcome_Physical
chemical and clinical pregnancy rates
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Outcome_Physical
number of retrieved oocytes
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Outcome_Physical
Follicle stimulating hormone ( FSH ) , luteinizing hormone ( LH ) levels , number of follicles , number of follicles > 18 mm , relative frequency of mature oocytes , number and days of gonadotropin injections , day of human chorionic gonadotropin ( HCG ) administration , estradiol level and abortion
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Participant_Condition
polycystic ovarian syndrome
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Participant_Condition
( PCOS )
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Participant_Condition
patients with PCOS undergoing controlled ovarian hyperstimulation ( COH ) with GnRH agonist
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Participant_Sample-size
112