36432
document
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence . We conducted a single-blind , random assignment , placebo-controlled , 12-week comparison of desipramine hydrochloride and amantadine hydrochloride as adjunctive treatments to counseling for cocaine dependence . Subjects were 54 outpatients who met DSM III-R criteria for active cocaine dependence and who completed a minimum of 2 weeks of treatment . Subjects treated with fixed doses of 200 mg/day desipramine ( N = 17 ) , 400 mg/day amantadine-placebo ( N = 16 ) , and placebo ( N = 21 ) did not differ for lifetime cocaine use , lifetime histories of psychopathology , admission scores on psychometric assessments , and sociodemographics . All treatment groups demonstrated dramatic and persistent decreases in cocaine use , craving for cocaine , and psychiatric symptoms consequent to treatment . Although there was a trend for more dropouts by subjects taking desipramine , there were no significant differences among treatment groups regarding retention in treatment , craving for cocaine , and decreased cocaine use confirmed by urine toxicology . There was a trend for subjects treated with desipramine to maintain longer periods of cocaine abstinence . Mean plasma concentration of desipramine in a subsample of our subjects was less than that recommended for treatment of depression , thus the dosage of desipramine may have been subtherapeutic .
36433
Intervention_Pharmacological
amantadine
36434
Intervention_Pharmacological
desipramine
36435
Intervention_Psychological
psychotherapy
36436
Intervention_Control
placebo-controlled
36437
Intervention_Pharmacological
desipramine hydrochloride
36438
Intervention_Pharmacological
amantadine hydrochloride
36439
Intervention_Pharmacological
desipramine
36440
Intervention_Pharmacological
amantadine-placebo
36441
Intervention_Control
placebo
36442
Intervention_Pharmacological
desipramine
36443
Intervention_Pharmacological
desipramine
36444
Intervention_Pharmacological
desipramine
36445
Intervention_Pharmacological
desipramine
36446
Outcome_Mental
dramatic and persistent decreases
36447
Outcome_Mental
cocaine use
36448
Outcome_Mental
craving for cocaine
36449
Outcome_Mental
psychiatric symptoms
36450
Outcome_Other
dropouts
36451
Outcome_Other
retention in treatment
36452
Outcome_Mental
craving for cocaine
36453
Outcome_Mental
decreased cocaine use
36454
Outcome_Other
urine toxicology
36455
Outcome_Mental
cocaine abstinence
36456
Outcome_Physical
Mean plasma concentration of desipramine
36457
Participant_Condition
cocaine dependence
36458
Participant_Sample-size
54