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Risk of infection after penetrating abdominal trauma . To identify the risk factors for the development of postoperative septic complications in patients with intestinal perforation after abdominal trauma , and to compare the efficacies of single-drug and dual-drug prophylactic antibiotic therapy , we studied 145 patients who presented with abdominal trauma and intestinal perforation at two hospitals between July 1979 and June 1982 . Logistic-regression analysis showed that a higher risk of infection ( P less than 0.05 ) was associated with increased age , injury to the left colon necessitating colostomy , a larger number of units of blood or blood products administered at surgery , and a larger number of injured organs . The presence of shock on arrival , which was found to increase the risk of infection when this factor was analyzed individually , did not add predictive power . Patients with postoperative sepsis were hospitalized significantly longer than were patients without infection ( 13.8 vs. 7.7 days , P less than 0.0001 ) . Both treatment regimens -- cefoxitin given alone and clindamycin and gentamicin given together -- resulted in similar infection rates , drug toxicity , duration of hospitalization , and costs .
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Intervention_Pharmacological
single-drug and dual-drug prophylactic antibiotic therapy
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Intervention_Pharmacological
cefoxitin
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Intervention_Pharmacological
clindamycin
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Intervention_Pharmacological
gentamicin
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Outcome_Adverse-effects
risk of infection
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Outcome_Other
hospitalized significantly
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Outcome_Adverse-effects
infection rates , drug toxicity
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Outcome_Other
duration of hospitalization , and costs
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Participant_Condition
intestinal perforation
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Participant_Condition
abdominal trauma
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Participant_Sample-size
145
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Participant_Condition
abdominal trauma
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Participant_Condition
intestinal perforation
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Participant_Condition
postoperative sepsis