68033
document
Comparison of intrathecal bupivacaine , levobupivacaine for cesarean section . BACKGROUND Some investigators found a greater incidence of hypotension in patients receiving intrathecal hyperbaric solution than in patients receiving plain solution for cesarean section . OBJECTIVE Compare the effects of intrathecal hyperbaric bupivacaine 10 mg with intrathecal bupivacaine 11 mg and intrathecal levobupivacaine 11 mg , all with 10 microg of fentanyl , for cesarean section . MATERIAL AND METHOD This prospective , randomized , double-blinded study was approved by the Ethics Committee . Ninety ASA I-II parturients undergoing elective cesarean section were enrolled . Group H received 10 mg of 0.5 % hyperbaric bupivacaine plus fentanyl 10 g , Group B received 11 mg of 0.5 % bupivacaine plus fentanyl 10 g , and Group L received 11 mg of 0.5 % levobupivacaine plus fentanyl 10 g. Spinal anesthesia ( SA ) was undertaken in right lateral position and spinal solutions were injected approximately 30 to 40 seconds . Sensory and motor block were assessed at 5-minute intervals . Side-effects such as hypotension , nausea , pruritus , shivering , and headache were recorded RESULTS Demographic data were similar in all groups . The level of an absence of cold sensation , the level of pinprick analgesia , and time to achieve sensory block to T4 level of Group H was significantly higher than Group B and Group L. The degree of motor block was comparable in all groups . The incidence of visceral pain was minimal , rated as mild pain and only found in Group B . The incidence of hypotension was comparable with Group H = 67 % , Group B = 56 % , and Group L = 50 % . Other side effects such as nausea , vomiting , pruritus , shivering , and headache were not statistically significant . Patient 's satisfaction rated as very good and was not different between the three groups . CONCLUSION The level of absence of cold sensation , level of pinprick analgesia , and time to achieve sensory block to T4 level were statistically higher in patients receiving hyperbaric bupivacaine than in patients receiving plain bupivacaine and plain levobupivacaine , while the differences were not statistically significant in all groups regarding effective surgical anesthesia , postoperative analgesia , and side effects . Therefore , Levobupivacaine can be an alternative to bupivacaine .
68034
Intervention_Pharmacological
intrathecal bupivacaine
68035
Intervention_Pharmacological
levobupivacaine
68036
Intervention_Pharmacological
intrathecal hyperbaric solution
68037
Intervention_Pharmacological
intrathecal hyperbaric bupivacaine
68038
Intervention_Pharmacological
intrathecal bupivacaine
68039
Intervention_Pharmacological
intrathecal levobupivacaine
68040
Intervention_Pharmacological
fentanyl
68041
Intervention_Pharmacological
0.5 % hyperbaric bupivacaine plus fentanyl 10 g
68042
Intervention_Pharmacological
0.5 % bupivacaine plus fentanyl 10 g
68043
Intervention_Pharmacological
11 mg of 0.5 % levobupivacaine plus fentanyl 10 g.
68044
Intervention_Physical
Spinal anesthesia ( SA )
68045
Intervention_Pharmacological
hyperbaric bupivacaine
68046
Intervention_Pharmacological
bupivacaine
68047
Intervention_Pharmacological
levobupivacaine
68048
Intervention_Pharmacological
Levobupivacaine
68049
Intervention_Pharmacological
bupivacaine
68050
Outcome_Physical
hypotension
68051
Outcome_Physical
nausea
68052
Outcome_Physical
pruritus
68053
Outcome_Physical
shivering
68054
Outcome_Physical
headache
68055
Outcome_Physical
absence of cold sensation
68056
Outcome_Physical
level of pinprick analgesia
68057
Outcome_Physical
time to achieve sensory block to T4 level
68058
Outcome_Physical
motor block
68059
Outcome_Pain
visceral pain
68060
Outcome_Physical
hypotension
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Outcome_Physical
nausea
68062
Outcome_Physical
vomiting
68063
Outcome_Physical
pruritus
68064
Outcome_Physical
shivering
68065
Outcome_Physical
headache
68066
Outcome_Other
satisfaction
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Outcome_Physical
The level of absence of cold sensation
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Outcome_Physical
level of pinprick analgesia
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Outcome_Other
time to achieve sensory block to T4 level
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Outcome_Physical
effective surgical anesthesia
68071
Outcome_Physical
postoperative analgesia
68072
Outcome_Adverse-effects
side effects
68073
Outcome_Other
alternative
68074
Participant_Condition
receiving intrathecal hyperbaric solution than in patients receiving plain solution for cesarean section
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Participant_Sample-size
Ninety
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Participant_Condition
ASA I-II parturients undergoing elective cesarean section