65932
document
Evaluation of postprocedure cognitive function using 3 distinct standard sedation regimens for endoscopic procedures . The primary purpose of this investigation was to evaluate postprocedure cognitive function associated with 3 distinct standard sedation regimens used for endoscopic procedures . A secondary aim was to identify complications requiring provider interventions . Subjects scheduled for colonoscopies were approached for enrollment the day of their procedure . A convenience sample of 96 subjects was randomly assigned . Cognitive function was recorded on the day of surgery using the Mini-Mental State Examination ( MMSE ) and 24 and 48 hours postoperatively using the Telephone Interview of Cognitive Status ( TICS ) . The propofol plus fentanyl group had a mean TICS score of 34.53 at 24 hours compared with 34.96 at 48 hours ( P = .017 ) . The midazolam plus fentanyl group had a mean TICS score of 34.76 at 24 hours compared with 36.26 at 48 hours ( P = .004 ) . The propofol-alone group had a mean TICS score of 35.09 at 24 hours compared with 35.98 at 48 hours ( P = .924 ) . The results of this investigation indicate that the sedation regimen of propofol alone has the least impact on postprocedure cognitive function . Additionally , the number of jaw lift interventions was significantly higher in both groups who received fentanyl .
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Intervention_Physical
sedation regimens
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Intervention_Physical
standard sedation regimens
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Intervention_Educational
Mini-Mental State Examination
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Intervention_Educational
Telephone Interview of Cognitive Status
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Intervention_Pharmacological
propofol plus fentanyl
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Intervention_Pharmacological
midazolam plus fentanyl
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Intervention_Pharmacological
propofol-alone
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Intervention_Pharmacological
propofol
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Intervention_Pharmacological
fentanyl
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Outcome_Mental
cognitive function
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Outcome_Mental
postprocedure cognitive function
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Outcome_Mental
Telephone Interview of Cognitive Status ( TICS )
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Outcome_Mental
mean TICS score
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Outcome_Mental
mean TICS score
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Outcome_Mental
mean TICS score
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Outcome_Mental
postprocedure cognitive function
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Outcome_Other
number of jaw lift interventions
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Participant_Condition
scheduled for colonoscopies