74394
document
Arginine vasopressin dissociates the diuresis and natriuresis due to atrial natriuretic factor in man . The possible interaction between arginine vasopressin ( AVP ) and atrial natriuretic factor ( ANF ) in the control of urinary sodium and water excretion was investigated in man . Nine healthy male volunteers undergoing stable maximal water diuresis were studied on four separate occasions . Atrial natriuretic factor 15 pmol kg-1 min-1 or placebo ( P ) was concomitantly administered against a background infusion of either AVP 0.003 pmol kg-1 min-1 or P ; thus the combinations P + P , AVP + P , P + ANF and AVP + ANF were studied . Atrial natriuretic factor caused a significant increase in sodium excretion ( UNaV ) [ +56 % ] , urinary flow rate ( V ) [ +17 % ] and free water clearance ( CH2O ) [ +23 % ] ; creatinine clearance ( Ccr ) did not change . Arginine vasopressin reduced V ( -58 % ) and CH2O ( -68 % ) but did not alter UNaV or Ccr . On the AVP + ANF study day , UNaV increased ( +64 % ) as with P + ANF , but V ( -44 % ) and CH2O ( -52 % ) continued to decrease below baseline levels ; analysis of variance showed this antidiuresis reflected the prevalent effect of AVP rather than any specific interaction . These results show that AVP is able to dissociate the natriuretic and diuretic effects of ANF .
74395
Intervention_Pharmacological
Arginine vasopressin
74396
Intervention_Pharmacological
arginine vasopressin ( AVP )
74397
Intervention_Pharmacological
Atrial natriuretic factor
74398
Intervention_Pharmacological
placebo
74399
Intervention_Pharmacological
AVP
74400
Intervention_Pharmacological
P
74401
Intervention_Pharmacological
ANF
74402
Intervention_Pharmacological
Atrial natriuretic factor
74403
Intervention_Pharmacological
Arginine vasopressin
74404
Intervention_Pharmacological
AVP
74405
Intervention_Pharmacological
ANF
74406
Outcome_Physical
diuresis and natriuresis
74407
Outcome_Physical
sodium excretion ( UNaV )
74408
Outcome_Physical
urinary flow rate ( V )
74409
Outcome_Physical
free water clearance ( CH2O )
74410
Outcome_Physical
creatinine clearance ( Ccr )
74411
Outcome_Physical
V
74412
Outcome_Physical
CH2O
74413
Outcome_Physical
UNaV or Ccr
74414
Outcome_Physical
UNaV
74415
Outcome_Physical
P + ANF
74416
Outcome_Physical
V
74417
Outcome_Physical
CH2O
74418
Outcome_Physical
natriuretic and diuretic effects
74419
Participant_Sex
man .
74420
Participant_Sex
man .