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document
Mapping from disease-specific measures to health-state utility values in individuals with migraine . OBJECTIVE The objective of this study was to develop empirical algorithms that estimate health-state utility values from disease-specific quality-of-life scores in individuals with migraine . METHODS Data from a cross-sectional , multicountry study were used . Individuals with episodic and chronic migraine were randomly assigned to training or validation samples . Spearman 's correlation coefficients between paired EuroQol five-dimensional ( EQ-5D ) questionnaire utility values and both Headache Impact Test ( HIT-6 ) scores and Migraine-Specific Quality-of-Life Questionnaire version 2.1 ( MSQ ) domain scores ( role restrictive , role preventive , and emotional function ) were examined . Regression models were constructed to estimate EQ-5D questionnaire utility values from the HIT-6 score or the MSQ domain scores . Preferred algorithms were confirmed in the validation samples . RESULTS In episodic migraine , the preferred HIT-6 and MSQ algorithms explained 22 % and 25 % of the variance ( R ( 2 ) ) in the training samples , respectively , and had similar prediction errors ( root mean square errors of 0.30 ) . In chronic migraine , the preferred HIT-6 and MSQ algorithms explained 36 % and 45 % of the variance in the training samples , respectively , and had similar prediction errors ( root mean square errors 0.31 and 0.29 ) . In episodic and chronic migraine , no statistically significant differences were observed between the mean observed and the mean estimated EQ-5D questionnaire utility values for the preferred HIT-6 and MSQ algorithms in the validation samples . CONCLUSIONS The relationship between the EQ-5D questionnaire and the HIT-6 or the MSQ is adequate to use regression equations to estimate EQ-5D questionnaire utility values . The preferred HIT-6 and MSQ algorithms will be useful in estimating health-state utilities in migraine trials in which no preference-based measure is present .
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Intervention_Educational
EuroQol five-dimensional ( EQ-5D ) questionnaire
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Intervention_Educational
Migraine-Specific Quality-of-Life Questionnaire version 2.1 ( MSQ )
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Intervention_Educational
HIT-6
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Intervention_Educational
MSQ algorithms
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Intervention_Educational
HIT-6
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Intervention_Educational
MSQ algorithms
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Intervention_Educational
HIT-6
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Intervention_Educational
MSQ
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Intervention_Physical
HIT-6
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Intervention_Physical
MSQ
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Outcome_Other
Spearman 's correlation coefficients
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Outcome_Physical
Headache Impact Test ( HIT-6 )
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Outcome_Other
Migraine-Specific Quality-of-Life Questionnaire version 2.1 ( MSQ ) domain scores
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Outcome_Physical
mean observed and the mean estimated EQ-5D questionnaire utility values
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Participant_Condition
individuals with migraine .
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Participant_Condition
individuals with migraine .
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Participant_Condition
Individuals with episodic and chronic migraine