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document
Continued improvement in pressure-flow parameters in men receiving finasteride for 2 years . Finasteride Urodynamics Study Group . OBJECTIVES To assess the long-term effects of finasteride on pressure-flow parameters in men with urodynamically documented bladder outflow obstruction ( BOO ) . METHODS One hundred twenty-one men with benign prostatic enlargement ( BPE ) and lower urinary tract symptoms ( LUTS ) underwent a pressure-flow study ( PFS ) at 1 of 11 clinical centers . The PFS technique was standardized , and all tracings were read by a single reader unaware of the treatment group . Patients who were obstructed according to a modified Abrams-Griffiths nomogram were randomized to 5 mg finasteride ( n = 81 ) or placebo ( n = 40 ) for 12 months ; all patients continuing into an open extension received finasteride during the second 12 months of therapy . Results of the initial 12-month study demonstrated the benefit of finasteride treatment on PFS parameters . To examine the continuing effects over time , an analysis of the data from 54 patients who completed 24 months of treatment with finasteride is provided . RESULTS Detrusor pressure at maximum flow ( PdetQmax ) continued to decrease during the second 12 months of therapy ( decreases of 5.3 and 11.7 cm H2O at months 12 and 24 , respectively ) . The percentage of patients obstructed by Abrams-Griffiths classification decreased from 76.2 % at baseline to 66.7 % at month 12 and 59.6 % at month 24 . An intention-to-treat analysis yielded similar results . CONCLUSIONS Finasteride improves urodynamic measures of obstruction in men with BPE and LUTS , with continued improvement during the second 12 months of therapy .
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Intervention_Pharmacological
5 mg finasteride
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Intervention_Control
placebo
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Intervention_Pharmacological
finasteride
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Outcome_Other
pressure-flow parameters
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Outcome_Other
pressure-flow parameters
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Outcome_Other
modified Abrams-Griffiths nomogram
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Outcome_Other
PFS parameters
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Outcome_Other
Detrusor pressure
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Outcome_Physical
PdetQmax
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Outcome_Other
Abrams-Griffiths classification
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Participant_Sex
men
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Participant_Condition
receiving finasteride for 2 years .
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Participant_Condition
with urodynamically documented bladder outflow obstruction ( BOO )
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Participant_Sample-size
One hundred twenty-one
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Participant_Condition
benign prostatic enlargement
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Participant_Condition
lower urinary tract symptoms