48636
document
[ Accelerated postoperative radiotherapy in patients with advanced larynx cancer ] . AIM The aim of study was test efficacy of accelerated postoperative radiotherapy -- concomitant boost in patients with advanced larynx cancer . METHODS AND MATERIALS The prospective study included 112 patients with advanced larynx cancer after radical surgical treatment . Patients had postoperative radiation therapy , conventional ( C ) or accelerated ( CB ) . RESULTS The 3-year overall survival in CB was 59 % , in C -- 58 % ( p = 0.2 ) , 3-year locoregional control in CB -- 83 % , in C -- 75 % ( p = 0.01 ) , the 3-year disease free survival was in CB -- 72 % , C -- 66 % ( p = 0.1 ) . CONCLUSION Concomitant boost postoperative radiation therapy did not improve overall survival , loco-regional control , disease free survival . Patients with close surgical margins , longer interval between surgery and radiation , high level of hemoglobin , T4 had benefit from accelerated radiotherapy .
48637
Intervention_Physical
Accelerated postoperative radiotherapy
48638
Intervention_Physical
accelerated postoperative radiotherapy -- concomitant boost
48639
Intervention_Surgical
radical surgical treatment
48640
Intervention_Physical
postoperative radiation therapy
48641
Intervention_Control
conventional ( C )
48642
Intervention_Physical
accelerated ( CB )
48643
Intervention_Physical
CB
48644
Intervention_Physical
CB
48645
Intervention_Physical
CB
48646
Intervention_Physical
Concomitant boost postoperative radiation therapy
48647
Intervention_Physical
accelerated radiotherapy
48648
Outcome_Other
efficacy
48649
Outcome_Mortality
3-year overall survival
48650
Outcome_Physical
3-year locoregional control
48651
Outcome_Mortality
3-year disease free survival
48652
Outcome_Mortality
overall survival
48653
Outcome_Other
loco-regional control
48654
Outcome_Mortality
disease free survival
48655
Participant_Condition
patients with advanced larynx cancer
48656
Participant_Condition
patients with advanced larynx cancer
48657
Participant_Sample-size
112 patients
48658
Participant_Condition
advanced larynx cancer after radical surgical treatment
48659
Participant_Condition
Patients with close surgical margins