38433
document
Effects of flumazenil on cerebral blood flow and oxygen consumption after midazolam anaesthesia for craniotomy . Cerebral blood flow ( CBF ) and cerebral metabolic rate for oxygen ( CMRO2 ) were measured by a modification of the Kety-Schmidt technique using i.v . xenon-133 in 20 patients undergoing craniotomy for supratentorial cerebral tumours . Anaesthesia was induced and maintained with midazolam , fentanyl and nitrous oxide . Pancuronium was given for neuromuscular block . The lungs were ventilated to normocapnia . The first flow measurements were performed approximately 1 h after induction of anaesthesia . At the end of operation the patients were allocated to two groups . Ten patients were given flumazenil 0.01 mg kg-1 and 5 min later the second flow measurement was performed . In the other 10 patients the second flow measurement was performed before the administration of flumazenil . Plasma concentrations of midazolam were measured at the time of each measurement of CBF . There was no difference between the groups in plasma concentration of midazolam , CBF or CMRO2 . Flumazenil had no effect on CBF and CMRO2 .
38434
Intervention_Pharmacological
flumazenil
38435
Intervention_Pharmacological
midazolam
38436
Intervention_Pharmacological
craniotomy
38437
Intervention_Pharmacological
midazolam
38438
Intervention_Pharmacological
fentanyl
38439
Intervention_Pharmacological
nitrous oxide
38440
Intervention_Pharmacological
Pancuronium
38441
Intervention_Pharmacological
flumazenil
38442
Intervention_Pharmacological
flumazenil
38443
Intervention_Pharmacological
midazolam
38444
Intervention_Pharmacological
midazolam
38445
Intervention_Pharmacological
Flumazenil
38446
Outcome_Physical
cerebral blood flow
38447
Outcome_Physical
oxygen consumption
38448
Outcome_Physical
Cerebral blood flow ( CBF )
38449
Outcome_Physical
cerebral metabolic rate for oxygen ( CMRO2 )
38450
Outcome_Physical
Plasma concentrations of midazolam
38451
Outcome_Physical
plasma concentration of midazolam
38452
Outcome_Physical
CBF
38453
Outcome_Physical
CMRO2
38454
Outcome_Physical
no effect on CBF
38455
Outcome_Physical
CMRO2