74266
document
No effect of acetylsalicylic acid on B-thromboglobulin and platelet factor 4 plasma levels in patients with transient ischaemic attacks . We studied the effect of acetylsalicylic acid ( ASA ) versus placebo on B-thromboglobulin ( B-TG ) and platelet factor 4 ( PF4 ) plasma levels and ADP-induced platelet aggregation in 25 male patients with transient ischaemic attacks ( TIA ) . The patients were allocated randomly to two groups : 14 patients received oral treatment with ASA 500 mg b.i.d . for 14 days , 11 patients placebo b.i.d . for the same period . B-TG and PF4 plasma levels and ADP-induced platelet aggregation were determined in basal conditions , and two hours , and seven and fourteen days after starting with ASA or placebo . In addition , the same parameters were studied in a group of 20 healthy males of matched age . Basal levels of plasma B-TG and PF4 and the maximal amplitude of ADP-induced platelet aggregation were abnormally high in TIA patients . ASA caused a significant reduction of B-TG plasma levels in TIA patients 2 hours after the first administration , but no effect was observed at the 7th and 14th day of treatment . PF4 plasma levels were unaffected by ASA treatment . It is concluded that ASA , at the dose conventionally used in clinical trials , does not affect the release of two alpha-granule proteins .
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Intervention_Pharmacological
acetylsalicylic acid
74268
Intervention_Pharmacological
acetylsalicylic acid ( ASA )
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Intervention_Control
placebo
74270
Intervention_Pharmacological
ASA
74271
Intervention_Control
placebo
74272
Outcome_Physical
B-thromboglobulin and platelet factor 4 plasma levels
74273
Outcome_Physical
B-thromboglobulin ( B-TG ) and platelet factor 4 ( PF4 ) plasma levels and ADP-induced platelet aggregation
74274
Outcome_Physical
B-TG and PF4 plasma levels and ADP-induced platelet aggregation
74275
Outcome_Physical
Basal levels of plasma B-TG and PF4
74276
Outcome_Physical
amplitude of ADP-induced platelet aggregation
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Outcome_Physical
B-TG plasma levels
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Outcome_Physical
PF4 plasma levels
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Participant_Condition
transient ischaemic attacks
74280
Participant_Sample-size
25
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Participant_Sex
male
74282
Participant_Condition
transient ischaemic attacks ( TIA )
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Participant_Sample-size
20
74284
Participant_Sex
males