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Prazosin versus captopril as initial therapy . Effect on hypertension and lipid levels . A randomized , parallel group study evaluated the safety , efficacy , and effect of the alpha blocking agent prazosin and the angiotensin converting enzyme inhibitor captopril on serum lipid levels in patients with mild to moderate hypertension . Baseline evaluations were performed on 31 patients after a four-week placebo washout period . Patients were randomly assigned to receive either prazosin ( n = 15 ) or captopril ( n = 16 ) . Daily doses were titrated as follows : for prazosin , 1 mg two times daily to maximum of 20 mg per day ; for captopril , 25 mg three times daily to a maximum of 450 mg per day . If diastolic blood pressure was not adequately controlled ( less than 85 mm Hg ) after four weeks of monotherapy , 1 mg of polythiazide was added to the daily regimen . There were no statistically significant differences between the drug groups for the measured variables in either the parallel or crossover phase of the study . Five of 15 prazosin-treated patients and six of 16 captopril-treated patients required the addition of thiazide to achieve blood pressure control .
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Intervention_Pharmacological
Prazosin
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
prazosin
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
prazosin
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
prazosin
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Intervention_Pharmacological
captopril
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Intervention_Pharmacological
polythiazide
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Intervention_Pharmacological
prazosin-treated
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Intervention_Pharmacological
thiazide
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Outcome_Physical
hypertension and lipid levels
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Outcome_Other
safety , efficacy , and effect
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Outcome_Physical
diastolic blood pressure
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Outcome_Physical
blood pressure control
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Participant_Condition
hypertension and lipid levels .