82622
document
Profound luteinizing hormone suppression after stopping the gonadotropin-releasing hormone-agonist leuprolide acetate . OBJECTIVE To compare levels of serum LH during continued use of leuprolide acetate ( LA ) with levels during the first week after discontinuing LA . DESIGN Prospective controlled study . SETTING Clinical assisted conception program . PATIENTS Women undergoing controlled ovarian stimulation for assisted conception were randomized to receive LA according to " short " or " ultrashort " protocols . The alternative protocol was used then in a second cycle . Each patient was thus her own control . MAIN OUTCOME MEASURES Serum LH over time . RESULTS When LA was stopped after 5 days of administration , LH levels fell profoundly when compared with levels when LA was continued . CONCLUSION Loss of LH after stopping LA is likely to be clinically important in ovarian stimulation regimens that use pure FSH with LA in ultrashort protocols . The fall in LH lasts at least 1 week and may be explainable by persistent suppression of endogenous GnRH by LA during this time .
82623
Intervention_Pharmacological
gonadotropin-releasing hormone-agonist leuprolide acetate
82624
Intervention_Pharmacological
leuprolide acetate ( LA )
82625
Intervention_Pharmacological
LA
82626
Intervention_Pharmacological
LA
82627
Intervention_Pharmacological
LA
82628
Intervention_Pharmacological
LA
82629
Intervention_Pharmacological
LA
82630
Outcome_Mental
Serum LH over time
82631
Outcome_Physical
LH levels
82632
Outcome_Mental
LH
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Outcome_Physical
LH
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Participant_Sex
Women
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Participant_Condition
ovarian stimulation