67716
document
Caphosol ( ® ) mouthwash gives no additional protection against oral mucositis compared to cryotherapy alone in stem cell transplantation . A pilot study . PURPOSE To investigate if adding Caphosol ( ® ) , a mouthwash solution , to oral cryotherapy ( OC ) further protects against oral mucositis ( OM ) , a toxic painful complication to high dose chemotherapy . METHOD The study was a randomised , controlled , study design . Patients ≥16 years scheduled for allogeneic stem cell transplantation were included consecutively and randomised to experimental group receiving OC combined with Caphosol ( ® ) ( n = 20 ) or control group receiving OC only ( n = 20 ) . OC was given from start to end of HDCT . Caphosol ( ® ) , from day 0 to day 21 . RESULT There were no significant differences regarding age or gender between the groups . Mucositis was assessed with the World Health Organisation ( WHO ) grading scale . Pain was assessed with a 10 cm visual analogue scale ( VAS ) from 0 = no pain to 10 = worst imaginable pain . Start and duration of therapy with pain relieving drugs , serum C-reactive protein values , and number of days of hospitalisation were collected from the medical records . Data on OM , oral pain , use of i.v . opioids and total parenteral nutrition were collected during 22 days . There was no significant difference between the groups on OM , oral pain , use of i.v . opioids or TPN between the groups . CONCLUSION The study showed no additional effect of combining Caphosol ( ® ) with OC .
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Intervention_Pharmacological
Caphosol
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Intervention_Physical
cryotherapy
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Intervention_Physical
oral cryotherapy
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Intervention_Physical
OC
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Intervention_Pharmacological
Caphosol
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Participant_Condition
in stem cell transplantation
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Participant_Condition
design
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Participant_Age
Patients ≥16 years
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Participant_Condition
allogeneic stem cell transplantation
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Participant_Sample-size
control group