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document
Folic acid-based intervention in non-ST elevation acute coronary syndromes . Homocysteinemia is a risk factor for cardiovascular diseases . Folic acid combined with vitamins B ( 6 ) and B ( 12 ) is effective in lowering homocysteine levels . This randomized placebo-controlled study was designed to determine the effect of a folic acid-based supplement on secondary prevention of clinical events in non-ST-segment elevation acute coronary syndromes . The study comprised 240 patients with either unstable angina or non-ST-elevation myocardial infarction in the previous 2 weeks who were randomized to a folate group ( n =116 ) or a placebo group ( n =124 ) . The folate group received 1 mg folic acid , 400 microg vitamin B ( 12 ) , and 10 mg vitamin B ( 6 ) daily . Clinical outcomes within 6 months were assessed . The composite endpoint of death , nonfatal acute coronary syndrome , and serious re-hospitalization was significantly higher in the folate group ; serious re-hospitalization alone was significantly higher in this group . Advanced age and diabetes increased susceptibility to the composite outcome . Folic acid-based supplementation is not beneficial and may even be harmful in the secondary prevention of cardiovascular events in patients with unstable angina and non-ST-elevation myocardial infarction . Further studies on the safety of such supplements are suggested . Controlled Clinical Trials Registry no . ISRCTN30249553 .
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Intervention_Pharmacological
Folic acid-based intervention
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Intervention_Pharmacological
Folic acid
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Intervention_Pharmacological
vitamins B ( 6 ) and B ( 12 )
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
folic acid-based supplement
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Intervention_Pharmacological
folate
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Intervention_Control
placebo group
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Intervention_Pharmacological
folic acid
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Intervention_Pharmacological
vitamin B ( 12 )
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Intervention_Pharmacological
vitamin B ( 6 )
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Intervention_Pharmacological
Folic acid-based supplementation
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Outcome_Physical
homocysteine levels
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Outcome_Physical
Clinical outcomes
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Outcome_Mortality
death
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Outcome_Physical
nonfatal acute coronary syndrome
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Outcome_Other
serious re-hospitalization
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Outcome_Physical
Advanced age and diabetes
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Outcome_Physical
prevention of cardiovascular events
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Participant_Condition
non-ST elevation acute coronary syndromes .