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document
Albumin-glutaraldehyde bioadhesive ( " Bioglue " ) for prevention of postoperative complications after stapled hemorrhoidopexy : A randomized controlled trial . BACKGROUND Hemorrhoidopexy using the circumferential stapler is an established method for surgical treatment of patients with prolapsing hemorrhoids . Despite its advantages , complications such as anal canal stenosis , hemorrhage and anastomosis leak with eventual intrapelvic sepsis can cause serious postoperative problems . The aim of this study was to evaluate the utility of a surgical adhesive , the biological albumin-glutaraldehyde glue " Bioglue " , in reduction of these postoperative complications . PATIENTS AND METHODS Between January 2002 and November 2004 , 200 patients undergoing stapled hemorrhoidopexy were enrolled in a prospective , randomized clinical trial . One hundred patients were randomly assigned to the control group ; the study group consisted of 100 patients who received Bioglue in the mucosa anastomosis area . All patients received standardized postoperative analgesic , laxative and antibiotic treatment . We then evaluated the two groups for postoperative complications ( after surgery and 6 months postoperatively ) . RESULTS From the control group ( no Bioglue application ) , two patients presented with anal stenosis , two with hemorrhage , three had anastomosis leak and one had thrombosis , whereas none of the patients from the Bioglue group had any of these complications . Both groups had patients with severe postoperative pain ( 3 each ) and fecal incontinence ( 1 patient each ) . The overall difference in the number of complications in the two groups was statistically significant ( p < 0.05 ) . CONCLUSION In this first study using Bioglue in patients undergoing circumferential stapled hemorrhoidopexy we have shown that application of the glue is effective in reducing postoperative complications .
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Intervention_Pharmacological
Albumin-glutaraldehyde bioadhesive ( " Bioglue " )
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Intervention_Pharmacological
biological albumin-glutaraldehyde glue " Bioglue "
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Intervention_Surgical
stapled hemorrhoidopexy
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Intervention_Control
control group ;
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Intervention_Pharmacological
Bioglue in the mucosa anastomosis area
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Intervention_Pharmacological
standardized postoperative analgesic , laxative and antibiotic treatment
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Outcome_Adverse-effects
postoperative complications
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Outcome_Adverse-effects
postoperative complications
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Outcome_Adverse-effects
anal stenosis
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Outcome_Adverse-effects
hemorrhage
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Outcome_Adverse-effects
anastomosis leak
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Outcome_Adverse-effects
thrombosis
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Outcome_Adverse-effects
complications .
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Outcome_Adverse-effects
severe postoperative pain
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Outcome_Adverse-effects
fecal incontinence
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Outcome_Other
overall difference
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Outcome_Adverse-effects
number of complications
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Outcome_Other
effective
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Outcome_Adverse-effects
reducing postoperative complications .
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Participant_Sample-size
200 patients
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Participant_Condition
stapled hemorrhoidopexy
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Participant_Sample-size
One hundred patients