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document
The cardiovascular effects of sevoflurane and isoflurane after premedication of healthy dogs undergoing elective surgery . Sevoflurane and isoflurane are commonly used in veterinary anesthesia . The objective of this prospective , randomized , open-label clinical study was to compare the cardiovascular effects of sevoflurane and isoflurane via direct arterial blood pressure measurements and the lithium dilution cardiac output ( LDCO ) on premedicated healthy dogs undergoing elective tibial plateau leveling osteotomy ( TPLO ) . Nineteen client-owned dogs were included . All dogs were premedicated with hydromorphone ( 0.05 mg/kg IV and glycopyrrolate 0.01 mg/kg subcutaneously ) . Ten dogs were anesthetized with sevoflurane and nine dogs were anesthetized with isoflurane . Eighteen dogs were instrumented with a dorsal pedal arterial catheter , and one dog had a femoral arterial catheter . All dogs had continuous , direct systolic ( SAP ) , diastolic ( DAP ) , and mean arterial ( MAP ) blood pressure readings as well as heart rate ( HR ) , cardiac output ( CO ) , cardiac index ( CI ) , systemic vascular resistance ( SVR ) , systemic vascular resistance index ( SVRI ) , stroke volume variation ( SVV ) , and pulse pressure variation ( PPV ) recorded q 5 min during the surgical procedure . There was no significant statistical difference in all parameters between the sevoflurane and isoflurane treatment groups . Both sevoflurane and isoflurane inhalant anesthetics appear to have similar hemodynamic effects when used as part of a multimodal anesthetic protocol in premedicated healthy dogs undergoing an elective surgical procedure .
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Intervention_Pharmacological
sevoflurane
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Intervention_Pharmacological
isoflurane
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Intervention_Pharmacological
Sevoflurane
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Intervention_Pharmacological
isoflurane
62260
Intervention_Pharmacological
sevoflurane
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Intervention_Pharmacological
isoflurane
62262
Intervention_Pharmacological
hydromorphone
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Intervention_Pharmacological
glycopyrrolate
62264
Intervention_Pharmacological
sevoflurane
62265
Intervention_Pharmacological
isoflurane
62266
Intervention_Pharmacological
sevoflurane
62267
Intervention_Pharmacological
isoflurane
62268
Intervention_Pharmacological
sevoflurane
62269
Intervention_Pharmacological
isoflurane
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Outcome_Physical
direct systolic ( SAP ) , diastolic ( DAP ) , and mean arterial ( MAP ) blood pressure readings
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Outcome_Physical
heart rate ( HR ) , cardiac output ( CO ) , cardiac index ( CI ) , systemic vascular resistance ( SVR ) , systemic vascular resistance index ( SVRI ) , stroke volume variation ( SVV ) , and pulse pressure variation ( PPV )
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Participant_Condition
elective surgery
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Participant_Condition
elective tibial plateau leveling osteotomy ( TPLO )
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Participant_Sample-size
Nineteen client-owned