57931
document
Effect of aliskiren on proteinuria in non-diabetic chronic kidney disease : a double-blind , crossover , randomised , controlled trial . AIM To evaluate the proteinuria-lowering effect of a renin inhibitor ( aliskiren ) , compared to placebo and to an angiotensin-converting enzyme inhibitor ( perindopril ) , in patients with non-diabetic chronic kidney disease . METHODS A randomised , double-blind , crossover trial was performed in 14 patients with nondiabetic chronic kidney disease with 24-h mean proteinuria of 2.01 g ( 95 % CI , 1.36–2.66 ) and estimated creatinine clearance of 93±6.8 ml/min . The study consisted of five treatment periods . The patients were randomly assigned to receive aliskiren ( 150 mg ) , aliskiren ( 300 mg ) , perindopril ( 5 mg ) , perindopril ( 10 mg ) or placebo . RESULTS Aliskiren and perindopril reduced proteinuria . These effects were dose-dependent . Furthermore , 24-h proteinuria was reduced by 23 % ( mean 95 % CI ; 2–44 ) by treatment with aliskiren ( 150 mg ) , by 36 % ( 95 % CI , 17–55 ; P < 0.001 ) with aliskiren ( 300 mg ) , by 7.1 % ( 95 % CI , 11–26 ) with perindopril ( 5 mg ) and by 25 % ( 95 % CI , 11–39 ; P < 0.05 ) with perindopril ( 10 mg ) , compared to placebo . No significant difference was found between the effects of aliskiren and perindopril . CONCLUSIONS Aliskiren significantly reduced proteinuria . The antiproteinuric effect is probably similar to that of perindopril , for equivalent hypotensive dosages . The renin inhibitor provides a promising alternative approach for the treatment of patients with chronic proteinuric non-diabetic kidney disease .
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Intervention_Pharmacological
aliskiren
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Intervention_Pharmacological
renin inhibitor
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Intervention_Pharmacological
aliskiren
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Intervention_Control
placebo
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Intervention_Pharmacological
angiotensin-converting enzyme inhibitor
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Intervention_Pharmacological
perindopril
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Outcome_Physical
proteinuria
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Outcome_Other
proteinuria-lowering effect
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Outcome_Physical
proteinuria
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Outcome_Other
proteinuria
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Outcome_Other
antiproteinuric
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Participant_Condition
non-diabetic chronic kidney disease
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Participant_Sample-size
14
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Participant_Condition
nondiabetic chronic kidney disease
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Participant_Condition
chronic proteinuric non-diabetic kidney