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document
Different therapeutic modalities for treatment of melasma . BACKGROUND Chemical peels and topical depigmenting agents have become a popular modality in the treatment of melasma . AIMS To compare the clinical efficacy of trichloroacetic acid peel 20 % vs . Jessner 's solution peel vs. the topical mixture of hydroquinone 2 % and kojic acid . PATIENTS AND METHODS Forty five patients with melasma were randomly assigned into three groups of fifteen patients each . Group A received Jessner 's solution peel , group B received trichloroacetic acid peel 20 % , and group C received topical hydroquinone 2 % and kojic acid . All patients were seen in follow-up period after 16 weeks ; clinical evaluation using Melasma Area and Severity Index ( MASI ) score and photography were recorded before and after treatment and after 16 weeks . RESULTS There was a decrease in MASI score in all three groups after treatment and after follow-up period but after treatment MASI score was statistically significantly lower in group A than group C ( P = 0.01 ) , and it was also statistically significantly lower in group B than group C ( P < 0.001 ) but there was no statistically significant difference between groups A and B . After the follow-up period , MASI score was statistically significantly lower in group A than group C ( P < 0.001 ) , statistically significantly lower in group B than group C ( P < 0.001 ) , and statistically significantly lower in group B than group A ( P = 0.035 ) . The statistical analysis was done through one-way anova followed by least significant difference ( LSD ) . CONCLUSION Trichloroacetic acid 20 % showed better results than Jessner 's solution as peeling agent and hydroquinone 2 % with kojic acid as a topical agent in the treatment of melasma .
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Intervention_Pharmacological
Chemical peels
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Intervention_Pharmacological
topical depigmenting agents
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Intervention_Pharmacological
trichloroacetic acid peel 20 % vs
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Intervention_Pharmacological
Jessner 's solution peel vs. the topical mixture of hydroquinone 2 % and kojic acid
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Intervention_Pharmacological
Jessner 's solution peel
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Intervention_Pharmacological
trichloroacetic acid peel 20 %
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Intervention_Pharmacological
topical hydroquinone 2 % and kojic acid
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Intervention_Pharmacological
Trichloroacetic acid 20 %
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Intervention_Pharmacological
Jessner 's solution
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Intervention_Pharmacological
hydroquinone 2 % with kojic acid
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Outcome_Other
clinical efficacy
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Outcome_Physical
Melasma Area and Severity Index ( MASI ) score and photography
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Outcome_Physical
MASI score
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Outcome_Physical
MASI score
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Outcome_Physical
MASI score
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Participant_Sample-size
Forty five
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Participant_Condition
melasma