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document
A prospective , randomized trial of clear liquids versus low-fat solid diet as the initial meal in mild acute pancreatitis . BACKGROUND & AIMS Patients recovering from mild acute pancreatitis typically receive a clear liquid diet ( CLD ) when ready to initiate oral nutrition . Patient discharge then depends on their successful advancement to solid food . We hypothesized that initiating oral nutrition with a low-fat solid diet ( LFSD ) after mild pancreatitis would be well tolerated and would result in a shorter length of hospitalization ( LOH ) . METHODS Patients with mild pancreatitis were randomized to a CLD or LFSD when they were ready to resume oral nutrition . Decisions about diet advancement and hospital discharge were at the discretion of the medical team , without input from study team members . Patients were monitored daily for recurrence of pain , need to stop feeding , post-refeeding LOH ( primary end point ) , and for 28 days post-refeeding to capture re-admission rates . RESULTS We randomized 121 patients : 66 to CLD and 55 to LFSD . The number of patients requiring cessation of feeding because of pain or nausea was similar in both groups ( 6 % for CLD , 11 % for LFSD ; P = .51 ) . The median LOH after refeeding was identical in both groups ( 1-day interquartile range , 1-2 ; P = .77 ) . Patients in the LFSD arm consumed significantly more calories and grams of fat than those in the CLD arm during their first meal and on study day 1 . There was no difference in the 28-day re-admission rates between the 2 arms . CONCLUSIONS Initiating oral nutrition after mild acute pancreatitis with an LFSD appeared safe and provided more calories than a CLD , but did not result in a shorter LOH .
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Intervention_Physical
clear liquid diet ( CLD )
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Intervention_Physical
oral nutrition with a low-fat solid diet ( LFSD )
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Intervention_Physical
CLD
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Intervention_Physical
LFSD
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Outcome_Other
length of hospitalization
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Outcome_Pain
pain
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Outcome_Physical
need to stop feeding
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Outcome_Pain
,
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Outcome_Physical
post-refeeding LOH
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Outcome_Other
re-admission rates
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Outcome_Physical
number of patients requiring cessation of feeding
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Outcome_Pain
because of pain or
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Outcome_Physical
nausea
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Outcome_Physical
median LOH after refeeding
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Outcome_Physical
calories and grams of fat
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Outcome_Other
28-day re-admission rates
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Outcome_Physical
mild acute pancreatitis
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Outcome_Physical
LFSD
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Outcome_Other
LOH
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Participant_Condition
mild acute pancreatitis .
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Participant_Condition
mild acute pancreatitis
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Participant_Condition
mild pancreatitis
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Participant_Sample-size
121