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document
Validation of an FFQ for evaluation of EPA and DHA intake . OBJECTIVE To validate an FFQ for the assessment of dietary EPA and DHA against their relative concentrations in red blood cells ( RBC ) . DESIGN Cross-sectional analysis of baseline data . Intakes of marine food products and EPA and DHA were estimated by FFQ on the basis of consumption of marine food products in the last month . Fatty acid composition of RBC membranes was quantified by GC . SETTING Saint-François d'Assise Hospital , Québec , Canada . SUBJECTS A total of sixty-five middle-aged women who participated in a randomized clinical trial . RESULTS Spearman 's correlation coefficient between intake of EPA , DHA and EPA + DHA and their corresponding concentration in RBC was 0.46 , 0.40 and 0.42 , respectively ( all P < 0.05 ) . Multiple regression analysis of EPA+DHA intake and RBC EPA + DHA concentration indicated positive and significant correlations for oily fish ( beta = 0.44 , 95 % CI 0.16 , 0.72 , P = 0.0027 ) , total fish ( beta = 0.42 , 95 % CI 0.19 , 0.64 , P = 0.0005 ) and marine food products ( beta = 0.42 , 95 % CI 0.20 , 0.64 , P = 0.0003 ) . No other marine food products significantly predicted RBC EPA + DHA concentration . CONCLUSIONS Although the present validation study was undertaken among middle-aged women with low consumption of marine food products ( < 3 servings/week ) , our FFQ provided estimates of EPA and DHA intakes that correlated fairly well with their RBC concentrations . However , the absence of correlations between EPA + DHA intakes from different marine species suggests that a minimum EPA + DHA intake is necessary to observe a relationship with RBC EPA + DHA concentrations .
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Intervention_Pharmacological
EPA
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Intervention_Pharmacological
DHA
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Intervention_Physical
marine food products
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Intervention_Pharmacological
EPA
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Intervention_Pharmacological
DHA
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Intervention_Pharmacological
marine food products
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Outcome_Mental
EPA and DHA intake
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Outcome_Physical
EPA and DHA
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Outcome_Physical
relative concentrations in red blood cells ( RBC ) .