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document
[ Therapeutic efficacy of youdujing preparation in treating cervical high-risk human papilloma virus infection patients ] . OBJECTIVE To study the clinical efficacy and mechanisms of Youdujing ( YDJ ) preparation in treating the cervical high-risk human papilloma virus ( HR-HPV ) infection . METHODS Totally HR-HPV infection 70 patients were assigned to the treatment group and the control group using random single blind method , 35 cases in each group . YDJ external lotion and YDJ cream were applied to patients in the treatment group , while normal saline was applied for those in the control group . HR-HPV DNA detection was performed by the end of the 1st menstruation after 3 menstrual cycles . The cervical biopsy and cervical smear were performed using vaginoscope before and after treatment . The mRNA expression of human telomerase reverse transcriptase ( hTERT ) was detected from fresh tissues of the cervical lesion . RESULTS The total effective rate was 96.6 % in the treatment group , higher than that of the control group ( 70.00 % , P < 0.01 ) . Before treatment there was no statistical difference in the pathological results of the cervix and the mRNA expression of hTERT between the two groups ( P > 0.05 ) . The mRNA expression of hTERT decreased in the two groups after treatment , showing statistical difference ( P < 0.01 ) . Better effects on the pathological results of the cervix and the mRNA expression of hTERT were obtained in the treatment group after treatment ( P < 0.05 ) . CONCLUSION YDJ played a role in clearing HR-HPV infection and reversing the cervical precancerous changes possibly through down-regulating the mRNA expression of hTERT and lowering the telomerase activation .
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Intervention_Pharmacological
youdujing preparation
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Intervention_Pharmacological
Youdujing ( YDJ ) preparation
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Intervention_Control
treatment
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Intervention_Control
control
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Intervention_Control
YDJ external lotion and YDJ cream
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Intervention_Control
control
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Intervention_Other
YDJ
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Outcome_Other
Therapeutic efficacy
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Outcome_Physical
HR-HPV DNA detection
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Outcome_Physical
mRNA expression of human telomerase reverse transcriptase ( hTERT )
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Outcome_Other
total effective rate
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Outcome_Physical
pathological results of the cervix
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Outcome_Physical
mRNA expression of hTERT
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Outcome_Physical
mRNA expression of hTERT
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Outcome_Physical
mRNA expression of hTERT
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Outcome_Physical
cervical precancerous changes