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Laser conization versus cold knife conization . This prospective , randomized study compares , for the first time , measured blood loss at conization and within 24 hours after using either the cold knife technique or the carbon dioxide laser scalpel . One hundred and ten consecutive patients were evaluated . The median blood loss in the laser group of 55 patients was 4.6 milliliters at , and within , 24 hours after operation compared with 30.1 milliliters in the cold knife group of 55 patients . More important , however , is that the corresponding figures for the range of bleeding were 0.4 to 155.4 milliliters and 5.6 to 1,570.9 milliliters , respectively . The incidence rate for bleeding complications requiring surgical intervention was 1.8 per cet for the laser group and 14.6 per cent for the cold knife group . This difference was statistically significant , p less than 0.015 -- Fischer 's exact test . Conization for treatment of premalignant changes of the cervix uteri will probably remain the treatment of choice for some time to come . It is our opinion that , in the future , laser conization will replace cold knife conization .
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Intervention_Physical
Laser conization
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Intervention_Physical
cold knife conization
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Intervention_Physical
cold knife technique
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Intervention_Physical
carbon dioxide laser scalpel
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Intervention_Physical
cold knife
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Intervention_Physical
cold knife
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Intervention_Physical
laser
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Intervention_Physical
cold knife
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Outcome_Physical
median blood loss
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Outcome_Physical
range of bleeding
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Outcome_Adverse-effects
incidence rate for bleeding complications requiring surgical intervention
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Participant_Sample-size
One hundred and ten