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document
Efficacy of prophylactic ondansetron in a patient-controlled analgesia environment . We conducted a prospective , randomized , double-blind , placebo-controlled trial to examine the efficacy of prophylactic ondansetron on post-operative nausea and vomiting ( PONV ) during opioid patient-controlled analgesia ( PCA ) . In total , 374 patients using opioid PCA , but otherwise considered to be low risk for PONV , were randomly allocated to ondansetron ( 4 mg given intravenously and 16 mg added into the PCA pump ) or saline ( control group ) . PONV was evaluated in terms of nausea graded on a visual analogue scale , and the number of patients who experienced emetic episodes or needed rescue anti-emetics in the 48-h post-operative period . Patient satisfaction for PCA was scored at the end of the evaluation period . The only difference between the two groups was the higher number of headaches in the ondansetron group . In patients using opioid PCA , but with no other high risk factors for PONV , prophylactic ondansetron does not have any clinical benefit .
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
prophylactic ondansetron
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Intervention_Pharmacological
ondansetron
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Intervention_Pharmacological
saline
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Outcome_Adverse-effects
post-operative nausea and vomiting ( PONV )
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Outcome_Adverse-effects
PONV
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Outcome_Adverse-effects
nausea graded on a visual analogue scale
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Outcome_Adverse-effects
number of patients who experienced emetic episodes or needed rescue anti-emetics
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Outcome_Other
Patient satisfaction
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Outcome_Adverse-effects
higher number of headaches
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Outcome_Adverse-effects
PONV
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Participant_Sample-size
374
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Participant_Condition
PONV