24588
document
Comparative speed of kill of selamectin , imidacloprid , and fipronil- ( S ) -methoprene spot-on formulations against fleas on cats . The speed of kill of selamectin , imidacloprid , and fipronil- ( S ) -methoprene against Ctenocephalides felis infestations on cats for one month following a single treatment was evaluated . Eighty cats were randomly allocated so that there were 20 cats in four different treatment groups . On Days -2 , 7 , 14 , 21 , and 28 , each cat was infested with 100 adult C. felis from the Kansas 1 flea strain . Following initial application only imidacloprid had caused a significant reduction in adult fleas on treated cats within 6 hours , but by 24 hours all three formulations had killed 96.7 % of the fleas . At 7 days post treatment , all three formulations reduced flea populations within 6 and 24 hours by 68.4 % and 99.4 % , respectively . At 21 and 28 days after treatment , none of the formulations killed significant numbers of fleas as compared to controls within 6 hours of infestation . At 28 days after treatment , selamectin , fipronil- ( S ) -methoprene , and imidacloprid had killed 99.0 % , 86.4 % , and 72.6 % of the fleas within 48 hours of infestation , respectively . This study demonstrates that the speed of kill of residual flea products on cats decreases throughout the month following application . It also demonstrated that selamectin provided the highest level of residual activity on cats against the Kansas 1 flea strain .
24589
Intervention_Pharmacological
selamectin
24590
Intervention_Pharmacological
imidacloprid
24591
Intervention_Pharmacological
fipronil- ( S ) -methoprene
24592
Intervention_Pharmacological
selamectin , imidacloprid , and fipronil- ( S ) -methoprene
24593
Intervention_Pharmacological
imidacloprid
24594
Intervention_Pharmacological
selamectin
24595
Intervention_Pharmacological
fipronil- ( S ) -methoprene
24596
Intervention_Pharmacological
imidacloprid
24597
Outcome_Other
fleas
24598
Outcome_Other
reduction in adult fleas
24599
Outcome_Other
flea populations
24600
Outcome_Other
numbers of fleas
24601
Outcome_Other
fleas
24602
Outcome_Other
flea products
24603
Outcome_Other
residual activity
24604
Participant_Condition
fleas
24605
Participant_Condition
cats
24606
Participant_Sample-size
Eighty
24607
Participant_Condition
Kansas 1 flea