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document
Body size indexes for optimizing iodine dose for aortic and hepatic enhancement at multidetector CT : comparison of total body weight , lean body weight , and blood volume . PURPOSE To evaluate and compare total body weight ( TBW ) , lean body weight ( LBW ) , and estimated blood volume ( BV ) for the adjustment of the iodine dose required for contrast material-enhanced multidetector computed tomography ( CT ) of the aorta and liver . MATERIALS AND METHODS Institutional review committee approval and written informed consent were obtained . One hundred twenty patients ( 54 men , 66 women ; mean age , 64.1 years ; range , 19-88 years ) who underwent multidetector CT of the upper abdomen were randomized into three groups of 40 patients each : ( a ) TBW group ( 0.6 g of iodine per kilogram of TBW ) , ( b ) LBW group ( 0.821 g of iodine per kilogram of LBW ) , and ( c ) BV group ( men , 8.6 g of iodine per liter of BV ; women , 9.9 g of iodine per liter of BV ) . Change in CT number between unenhanced and contrast-enhanced images per gram of iodine and maximum hepatic enhancement ( MHE ) adjusted for iodine dose were examined for correlation with TBW , LBW , and BV by using linear regression analysis . RESULTS In the portal venous phase , correlation coefficients for the correlation of change in CT number per gram of iodine with TBW for the aorta and liver were -0.71 and -0.79 , respectively , in the TBW group ; -0.80 and -0.86 , respectively , in the LBW group ; and -0.68 and -0.66 , respectively , in the BV group . In the liver , they were marginally higher in the LBW group than in the BV group ( P = .03 ) . Adjusted MHE remained constant at 77.9 HU +/- 10.2 ( standard deviation ) in the LBW group with respect to TBW , but it increased in the TBW ( r = 0.80 , P < .001 ) and BV ( r = 0.70 , P < .001 ) groups as TBW increased . CONCLUSION When LBW , rather than TBW or BV , is used , the iodine dose required to achieve consistent hepatic enhancement may be estimated more precisely and with reduced patient-to-patient variability .
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Intervention_Pharmacological
iodine
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Intervention_Pharmacological
iodine dose
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Intervention_Physical
multidetector CT
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Intervention_Pharmacological
iodine
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Intervention_Pharmacological
iodine
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Intervention_Pharmacological
iodine
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Intervention_Pharmacological
iodine
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Intervention_Pharmacological
iodine
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Intervention_Pharmacological
iodine
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Outcome_Physical
total body weight ( TBW )
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Outcome_Physical
lean body weight ( LBW )
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Outcome_Physical
estimated blood volume ( BV )
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Outcome_Physical
correlation coefficients
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Outcome_Physical
correlation of change in CT number per gram
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Outcome_Physical
TBW
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Outcome_Physical
Adjusted MHE
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Outcome_Physical
LBW
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Outcome_Physical
TBW
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Outcome_Physical
TBW
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Outcome_Physical
BV
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Outcome_Physical
TBW
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Outcome_Physical
LBW
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Outcome_Physical
TBW
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Outcome_Physical
BV
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Participant_Condition
aortic and hepatic enhancement at multidetector CT :
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Participant_Condition
One hundred twenty patients ( 54 men , 66 women ; mean age , 64.1 years ; range , 19-88 years ) who underwent multidetector CT of the upper abdomen