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document
Stage II carcinoma of the ovary : an analysis of survival after comprehensive surgical staging and adjuvant therapy . Ninety-three women with FIGO stage II epithelial ovarian carcinoma underwent comprehensive surgical staging and were randomized prospectively to therapy consisting of either intraperitoneal radioactive phosphorus or oral melphalan . No patient had gross residual disease at the time of randomization . Ten of the forty-five women treated with melphalan experienced severe bone marrow depression at some time during therapy and two women expired from leukemia . Four of the forty-eight women treated with intraperitoneal phosphorus required surgical reexploration for intestinal obstruction or bowel injury . Twenty-one women died of their disease . Survival was not statistically different between the two treatment arms . The 5-year actuarial survival was 78 % .
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Intervention_Surgical
surgical staging
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Intervention_Physical
adjuvant therapy
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Intervention_Pharmacological
intraperitoneal radioactive phosphorus
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Intervention_Pharmacological
oral melphalan
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Intervention_Pharmacological
melphalan
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Intervention_Pharmacological
intraperitoneal phosphorus
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Outcome_Mortality
survival
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Outcome_Physical
severe bone marrow depression
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Outcome_Physical
expired from leukemia
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Outcome_Physical
surgical reexploration for intestinal obstruction or bowel injury
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Outcome_Mortality
died
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Outcome_Mortality
Survival
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Outcome_Mortality
5-year actuarial survival
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Participant_Condition
Stage II carcinoma of the ovary
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Participant_Sample-size
Ninety-three
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Participant_Sex
women
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Participant_Condition
FIGO stage II epithelial ovarian carcinoma
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Participant_Sample-size
forty-five
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Participant_Sex
women
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Participant_Sample-size
forty-eight
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Participant_Sex
women
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Participant_Condition
treated with intraperitoneal phosphorus