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Three-year clinical outcome after primary stenting of totally occluded native coronary arteries : a randomized comparison of bare-metal stent implantation with sirolimus-eluting stent implantation for the treatment of total coronary occlusions ( Primary Stenting of Totally Occluded Native Coronary Arteries [ PRISON ] II study ) . BACKGROUND The purpose of this study was to examine the 3-year clinical outcome in patients enrolled in the Primary Stenting of Totally Occluded Native Coronary Arteries II study . METHODS Patients with totally occluded coronary arteries randomized to either sirolimus-eluting Cypher stents ( SESs ) ( Cordis , a Johnson & Joshson Company , Miami Lakes , FL ) ( 100 patients ) or bare-metal BxVelocity stents ( BMSs ) ( Cordis ) ( 100 patients ) were followed clinically for 3 years . RESULTS Between 1 and 3 years , there were infrequent additional clinical events that were equally distributed between the SES and the BMS group . After 3 years , target lesion revascularization was 7 % in the SES group versus 27 % in the BMS group ( P < .001 ) ; and target vessel revascularization was seen in 11 % in the SES group versus 30 % in the BMS group ( P = .002 ) . Major adverse cardiac events were noted in 10 % of the SES group versus 34 % in the BMS group ( P < .001 ) . There were no statistically significant differences in death , myocardial infarction , and stent thrombosis according to the Academic Research Consortium criteria between the 2 groups . CONCLUSIONS Clinical outcome up to 3 years after implantation of SESs for total coronary occlusions continues to demonstrate a significant reduction in adverse clinical events compared with BMSs without the evidence for either disproportionate late restenosis or late stent thrombosis .
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Intervention_Physical
bare-metal stent implantation with sirolimus-eluting stent implantation
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Intervention_Surgical
sirolimus-eluting Cypher stents ( SESs )
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Intervention_Surgical
bare-metal BxVelocity stents ( BMSs )
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Outcome_Physical
target lesion revascularization
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Outcome_Physical
vessel revascularization
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Outcome_Adverse-effects
Major adverse cardiac events
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Outcome_Mortality
death
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Outcome_Physical
myocardial infarction
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Outcome_Physical
stent thrombosis
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Participant_Condition
occluded native coronary arteries
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Participant_Condition
total coronary occlusions
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Participant_Condition
Totally Occluded Native Coronary Arteries
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Participant_Condition
totally occluded coronary arteries
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Participant_Sample-size
100
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Participant_Sample-size
100