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Primary deep sclerectomy versus primary deep sclerectomy with the use of mitomycin C in primary open-angle glaucoma . PURPOSE To prospectively study and compare the effectiveness and the safety of primary deep sclerectomy with and without the use of mitomycin C in eyes with open-angle glaucoma . PATIENTS AND METHODS A total of 90 eyes of 90 patients with primary open-angle glaucoma or pseudoexfoliative glaucoma underwent deep sclerectomy . Patients were enrolled consecutively and assigned randomly to undergo deep sclerectomy without the use of mitomycin C ( DS group ) and deep sclerectomy with the application of mitomycin C ( DSMMC group ) in a concentration of 0.2 mg/mL for 2.5 minutes , before the superficial scleral flap formation . RESULTS The intraocular pressure was significantly decreased by 7.13 mm Hg or 27.59 % in the DS group and by 11.68 mm Hg or 42.25 % in the DSMMC group at the end of the follow-up period . The intraocular pressure reduction in the DSMMC group was statistically significant when compared with that in the DS group ( P < 0.05 ) . The complete ( IOP < 22 mm Hg without medication ) and qualified ( IOP < 22 mm Hg with or without medication ) success rates at the end of the follow-up period were 42.5 % and 72.5 % in the DS group and 50 % and 95 % in the DSMMC group . The qualified success rate in the DSMMC group was statistically significant when compared with that in the DS group . Differences in complications ( choroidal detachment , hyphema , leakage ) seen between the two groups were statistically nonsignificant . A hemorrhagic detachment of the Descemet membrane was observed in one eye in the DSMMC group . CONCLUSIONS The use of intraoperative mitomycin C during deep sclerectomy significantly reduced the postoperative IOP and increased the success rate of the procedure .
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Intervention_Surgical
Primary deep sclerectomy
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Intervention_Surgical
primary deep sclerectomy with the use of
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Intervention_Surgical
deep sclerectomy without the use of mitomycin C ( DS group )
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Intervention_Pharmacological
mitomycin C
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Outcome_Other
effectiveness
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Outcome_Other
safety
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Outcome_Physical
intraocular pressure
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Outcome_Other
success rates
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Outcome_Other
qualified success rate
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Outcome_Adverse-effects
( choroidal detachment , hyphema , leakage )
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Outcome_Physical
hemorrhagic detachment of the Descemet membrane
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Participant_Condition
primary open-angle glaucoma
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Participant_Condition
eyes with open-angle glaucoma
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Participant_Sample-size
90 eyes of 90 patients
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Participant_Condition
primary open-angle glaucoma or pseudoexfoliative glaucoma