79502
document
Effect of antacids on intragastric pH in healthy subjects and duodenal ulcer patients . Influence of the size of the antacid dose and of anticholinergics . Different doses of two liquid antacids , alone and combined with an anticholinergic agent , were studied with respect to the duration of antacid action . The studies were performed in healthy subjects with MAO less than 30 mmol/h and in duodenal ulcer patients with MAO greater than 35 mmol/h . Gastric pH was recorded using radiotelemetric technique ( Heidelberg capsule ) . In the healthy subjects , there was no significant difference in the duration of action with the different doses but in duodenal ulcer patients a tenfold increase of the antacid dose resulted in a doubling of the duration of action . Combined treatment with an anticholinergic and antacids enhanced the antacid effects in both groups . It is concluded that an antacid dose should be so great that it binds secreted acid before the dose leaves the stomach . Further increase of the dose will not increase the duration . Concomitant use of an anticholinergic agent increases the duration of antacid action .
79503
Intervention_Pharmacological
antacids
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Intervention_Pharmacological
antacid dose
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Intervention_Pharmacological
anticholinergics .
79506
Intervention_Pharmacological
antacids
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Intervention_Pharmacological
anticholinergic
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Intervention_Pharmacological
antacid
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Intervention_Pharmacological
anticholinergic
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Intervention_Pharmacological
antacids
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Intervention_Pharmacological
anticholinergic agent
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Outcome_Other
Effect
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Outcome_Physical
intragastric pH
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Outcome_Other
duration of antacid action
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Outcome_Physical
Gastric pH
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Outcome_Physical
radiotelemetric
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Outcome_Other
duration of action
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Outcome_Other
duration of action
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Outcome_Other
antacid effects
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Outcome_Other
duration
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Outcome_Other
duration of antacid action
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Participant_Condition
healthy subjects
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Participant_Condition
duodenal ulcer
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Participant_Condition
duodenal ulcer
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Participant_Condition
duodenal ulcer