20552
document
[ Relationship between sCD44v6 expression and TCM differentiation type of gastric carcinoma patients and influence of weitai capsule on the expression ] . OBJECTIVE To explore the relationship of TCM type with serum level of soluble CD44v6 ( sCD44v6 ) and different histologic parameters in gastric carcinoma patients and to observe the influence of Weitai capsule ( WTC ) on the sCD44v6 expression . METHODS TCM typing and sCD44v6 expression were determined in all the enrolled patients ( 30 in the control and 32 in the trial group ) before operation , and 3-4 courses of chemotherapy was applied to them from 3-4 weeks after operation . To the patients of trial group , oral administration of WTC was given additionally with 4 capsules , 3 times a day for consecutive 3 months . RESULTS sCD44v6 was significantly positive correlated with the degree of cancer cell differentiation , infiltration and lymph node metastasis ; ( 2 ) Level of sCD44v6 was the highest in patients of blood stasis type , as compared with that in the patients of Pi-deficiency type or of damp-heat type , the difference was significant ; ( 3 ) After ending treatment , level of sCD44v6 in the trial group was significantly lower than that in the control group . CONCLUSION ( 1 ) Serum level of sCD44v6 could be taken as the criterion for evaluating the development and prognosis of gastric cancer , as well as the therapeutic target for anti-metastasis treatment ; ( 2 ) Serum level of sCD44v6 is related to some extent with TCM type of blood stasis and Pi-deficiency ; ( 3 ) WTC combined with chemotherapy could further inhibit the expression of serum sCD44v6 in gastric carcinoma patients .
20553
Intervention_Pharmacological
weitai capsule
20554
Intervention_Pharmacological
Weitai capsule ( WTC )
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Intervention_Pharmacological
chemotherapy
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Intervention_Pharmacological
WTC
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Intervention_Pharmacological
WTC
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Intervention_Pharmacological
chemotherapy
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Outcome_Physical
sCD44v6 expression
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Outcome_Physical
expression
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Outcome_Physical
serum level of soluble CD44v6 ( sCD44v6 )
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Outcome_Physical
histologic parameters
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Outcome_Physical
sCD44v6 expression
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Outcome_Physical
TCM typing
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Outcome_Physical
sCD44v6 expression
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Outcome_Physical
sCD44v6
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Outcome_Physical
degree of cancer cell differentiation , infiltration and lymph node metastasis
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Outcome_Physical
Level of sCD44v6
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Outcome_Physical
level of sCD44v6
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Outcome_Physical
Serum level of sCD44v6
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Outcome_Physical
development and prognosis of gastric cancer
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Outcome_Physical
Serum level of sCD44v6
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Outcome_Physical
TCM type of blood stasis and Pi-deficiency
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Outcome_Physical
expression of serum sCD44v6
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Participant_Condition
gastric carcinoma
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Participant_Condition
gastric carcinoma
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Participant_Sample-size
30
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Participant_Sample-size
32
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Participant_Condition
blood stasis type
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Participant_Condition
Pi-deficiency type or of damp-heat type