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document
Procalcitonin is a good tool to guide duration of antibiotic therapy in patients with severe acute pancreatitis . A randomized prospective single-center controlled trial . OBJECTIVE To investigate the clinical usefulness of procalcitonin ( PCT ) for guiding duration of antibiotic therapy in patients with severe acute pancreatitis ( SAP ) . METHODS A total of 71 patients with confirmed severe acute pancreatitis from March 2009 to September 2011 in the Department of Critical Care Medicine of Huizhou Municipal Central Hospital , Guangdong , China were enrolled in this study . Procalcitonin was measured daily by a semi-quantitative immunoassay in the study group . Patients were randomly assigned into 2 groups including a PCT-guided group ( study group ) and a prophylactic antibiotic therapy ( control group ) . Antibiotic therapy in the study group was not applied until clinical signs and symptoms of infection appeared ( PCT value was > 0.5ng/ml ) . We discontinued the antibiotic therapy if clinical signs and symptoms of infection improved and PCT was < 0.5ng/ml over 3 days . In the control group , antibiotic therapy was administrated for 2 weeks , or antibiotic therapy was continued because of confirmed infection until clinical signs and symptoms of infection disappeared over 3 days . RESULTS In the study group ( 35 patients ) , the duration of antibiotic therapy and hospitalization was significantly shorter than the control group ( 36 patients ) ( 10.89+/-2.85 versus 16.06+/-2.48 days , p < 0.001 , and 16.66+/-4.02 days versus 23.81+/-7.56 days , p < 0.001 ) without negative clinical effects and the cost of hospitalization was significantly lower . CONCLUSION Procalcitonin is a helpful and safe tool for guiding duration of antibiotic treatment in patients with severe acute pancreatitis .
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Intervention_Pharmacological
Procalcitonin
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Intervention_Pharmacological
antibiotic therapy
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Intervention_Pharmacological
procalcitonin
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Intervention_Pharmacological
antibiotic therapy
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Intervention_Pharmacological
Procalcitonin
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Intervention_Educational
2 groups including a
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Intervention_Pharmacological
PCT-guided group ( study group )
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Intervention_Educational
a
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Intervention_Physical
prophylactic antibiotic therapy
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Intervention_Educational
( control group )
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Intervention_Pharmacological
Antibiotic therapy
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Intervention_Pharmacological
antibiotic therapy
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Intervention_Pharmacological
Procalcitonin
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Outcome_Other
duration of antibiotic therapy and hospitalization
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Outcome_Physical
negative clinical effects
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Outcome_Other
cost of hospitalization
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Participant_Condition
severe acute pancreatitis
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Participant_Condition
severe acute pancreatitis ( SAP )
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Participant_Sample-size
71 patients
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Participant_Condition
severe acute pancreatitis