1788
document
Gabexate mesilate and antithrombin III for intraoperative anticoagulation in heparin pretreated patients . Thirty patients scheduled for elective myocardial revascularization and having undergone preoperative heparin treatment have been admitted to this prospective , randomized study . The aim of the study was to test two different strategies for preserving circulating antithrombin III ( AT-III ) during cardiopulmonary bypass . Patients in the control group ( group C , n = 10 ) were treated with a standard heparinization ( 300 IU/kg ) . Patients in group A ( n = 10 ) received the same management plus two doses of purified antithrombin III ( 1000 IU each ) . Patients in group GA received 200 IU/kg heparin and a continuous infusion of heparin ( 100 IU/kg/h ) and gabexate mesilate ( 2 mg/kg/h ) plus the same dose of antithrombin III as group A . Both group A and group GA demonstrated a preservation of circulating AT-III when compared to group C ; this effect was more pronounced in group GA . The total heparin dosage was less in group GA than in groups A and C. Purified AT-III administration is recommended in heparin pretreated patients ; the addition of gabexate mesilate to this protocol decreases the heparin requirement and increases the AT-III preservation .
1789
Intervention_Pharmacological
Gabexate mesilate
1790
Intervention_Pharmacological
antithrombin III
1791
Intervention_Pharmacological
standard heparinization
1792
Intervention_Pharmacological
antithrombin III
1793
Intervention_Pharmacological
200 IU/kg heparin
1794
Intervention_Pharmacological
continuous infusion of heparin ( 100 IU/kg/h )
1795
Intervention_Pharmacological
gabexate mesilate
1796
Intervention_Pharmacological
antithrombin III
1797
Outcome_Physical
circulating antithrombin III ( AT-III )
1798
Outcome_Physical
preservation of circulating AT-III
1799
Outcome_Physical
total heparin dosage
1800
Outcome_Physical
heparin requirement
1801
Outcome_Physical
AT-III preservation .
1802
Participant_Condition
heparin pretreated
1803
Participant_Sample-size
Thirty
1804
Participant_Condition
elective myocardial revascularization
1805
Participant_Condition
preoperative heparin treatment
1806
Participant_Condition
heparin pretreated