79716
document
Two blind randomized cross-over trials in the treatment of primary open angle glaucoma . We present the results of two blind randomized trials comparing both guanethidine 3 per cent and adrenaline 0.5 per cent ( Ganda 3.0/0.5 ) and guanethidine 1 per cent and adrenaline 0.2 per cent ( Ganda 1.0/0.2 ) in single drop form with Timolol ( Timoptol ) 0.25 per cent . Results of 48-hour phasing at the end of one month 's treatment demonstrated a significantly greater fall in intraocular pressure with Ganda 3.0/0.5 ( 9.8 mm Hg ) than with Timolol 0.25 per cent ( 7.67 mm Hg ) P less than 0.001 . There was no significant difference in the fall in intraocular pressure between Ganda 1.0/0.2 ( 8.87 mm Hg ) and Timolol 0.25 per cent ( 8.24 mm Hg ) .
79717
Intervention_Pharmacological
guanethidine 3 per cent and adrenaline 0.5 per cent ( Ganda 3.0/0.5 )
79718
Intervention_Pharmacological
guanethidine 1 per cent
79719
Intervention_Pharmacological
adrenaline 0.2 per cent ( Ganda 1.0/0.2 )
79720
Intervention_Pharmacological
Timolol ( Timoptol ) 0.25 per cent
79721
Intervention_Pharmacological
Ganda 3.0/0.5
79722
Intervention_Pharmacological
Timolol 0.25 per cent
79723
Intervention_Pharmacological
Ganda 1.0/0.2
79724
Intervention_Pharmacological
Timolol 0.25 per cent
79725
Outcome_Physical
primary open angle glaucoma
79726
Outcome_Physical
fall in intraocular pressure
79727
Outcome_Physical
fall in intraocular pressure
79728
Participant_Condition
treatment of primary open angle glaucoma .