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document
Auditory evoked potential modifications according to clinical and biochemical responsiveness to fenfluramine treatment in children with autistic behavior . Evoked potentials to auditory stimulations varying in intensity were studied in 13 children with autistic behavior treated with fenfluramine . Modifications of both amplitude and single-trial potential variability were considered according to the clinical and biochemical responsiveness to this drug . Six children ( responders ) were clinically improved by the treatment . Electrophysiological data were affected according to the clinical and biochemical responsiveness to fenfluramine : the auditory evoked potential amplitude increased , and the single-trial potential variability decreased at each intensity level only in responders whose dopaminergic metabolism was significantly modified by fenfluramine treatment . No modification was found in nonresponders . Both biochemical and electrophysiological results argued for an amphetamine-like action of fenfluramine in those autistic children whose attention deficits are associated with motor disturbances including hyperactivity .
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Intervention_Pharmacological
fenfluramine treatment
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Intervention_Pharmacological
fenfluramine
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Intervention_Pharmacological
fenfluramine
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Intervention_Pharmacological
fenfluramine
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Outcome_Other
Modifications of both amplitude
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Outcome_Other
single-trial potential variability
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Outcome_Other
auditory evoked potential amplitude
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Outcome_Other
single-trial potential variability
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Outcome_Physical
dopaminergic metabolism
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Participant_Age
children
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Participant_Condition
autistic
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Participant_Sample-size
13
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Participant_Condition
autistic behavior
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Participant_Condition
fenfluramine .