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document
Topical anti-inflammatory drugs in the treatment of allergic pollinosic conjunctivitis : a comparative double-blind study . Anti-inflammatory drugs , i.e . glucocorticosteroids and NSAIDs ( nonsteroidal anti-inflammatory drugs ) , are often included in the treatment of allergic conjunctivitis . The present study compares the clinical efficacy and safety of topical hydrocortisone , acetylsalicylic acid ( ASA ) and piroxicam compared to placebo . The trial , designed as a double-blind , randomized and parallel-group treatment , was carried out in a group of 40 patients suffering from seasonal allergic conjunctivitis due to Parietaria pollen , during the pollen season ( June-July , 1990 ) . Patients received hydrocortisone 0.1 % solution , ASA 1 % solution , piroxicam 0.5 % solution or placebo as eye drops , all one drop in each eye q.i.d . for 14 days . The symptoms were evaluated at baseline and at the end of treatment by the clinician and by patients on a diary card . The hydrocortisone group showed a rapid and significant improvement during the first week of treatment , while ASA and piroxicam reduced symptomatology during the second week of treatment ; this difference was statistically significant . At the end of the trial , the active drugs were comparable with regard to clinical efficacy . A statistically significant difference was observed between the active drugs and placebo , while no statistically significant difference was observed among the three drugs . No serious side-effects were observed . The results demonstrate the clinical efficacy of anti-inflammatory drugs in the treatment of pollen-induced allergic conjunctivitis ; they also suggest the use of NSAIDs in long-term treatment , as their efficacy has been shown to be closely comparable to that of steroids , while avoiding the well-known side-effects of the latter in prolonged treatment .
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Intervention_Pharmacological
Topical anti-inflammatory drugs
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Intervention_Pharmacological
glucocorticosteroids and NSAIDs
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Intervention_Pharmacological
nonsteroidal anti-inflammatory drugs
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Intervention_Pharmacological
hydrocortisone
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Intervention_Pharmacological
acetylsalicylic acid ( ASA )
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Intervention_Pharmacological
piroxicam
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Intervention_Control
placebo
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Intervention_Pharmacological
hydrocortisone 0.1 % solution
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Intervention_Pharmacological
ASA 1 % solution
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Intervention_Pharmacological
piroxicam 0.5 % solution
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Intervention_Control
placebo
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Outcome_Other
efficacy and safety
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Outcome_Physical
symptomatology
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Outcome_Other
clinical efficacy .
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Outcome_Adverse-effects
serious side-effects
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Participant_Condition
allergic pollinosic conjunctivitis :
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Participant_Condition
allergic conjunctivitis .