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document
Plasma 3,4-dihydroxyphenylethyleneglycol and 3-methoxy-4-hydroxyphenylethyleneglycol as indicators of central noradrenergic activity . A comparative study on control subjects and depressed patients . Animal studies have suggested interspecies differences in brain norepinephrine ( NE ) metabolism , especially with regard to the relative proportions of 3,4-dihydroxyphenylethyleneglycol ( DOPEG ) compared to 3-methoxy-4-hydroxyphenylethyleneglycol ( MOPEG ) . In order to question the value of both glycol metabolites as peripheral indices of central noradrenergic activity , a comparative study of plasma DOPEG and MOPEG ( measured by HPLC ) related to depression , sex , age and diagnostic categories ( DSM-III ) was carried out on depressed and control subjects . In addition , two groups of 8 patients were randomly submitted to a desipramine 150 mg/day , or a metapramine 450 mg/day antidepressant treatment influencing the formation of DOPEG and MOPEG in a different way . The study did not demonstrate any difference between DOPEG and MOPEG for most of the experimental factors . We found also a significant positive correlation between plasma levels of DOPEG and MOPEG . Our results support the idea that each of these two biological indices can be used in the assessment of central noradrenergic activity .
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Intervention_Pharmacological
desipramine 150 mg/day
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Intervention_Pharmacological
a metapramine 450 mg/day antidepressant treatment
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Outcome_Physical
central noradrenergic activity
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Outcome_Physical
positive correlation between plasma levels of DOPEG and MOPEG
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Outcome_Physical
central noradrenergic activity
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Participant_Condition
depressed
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Participant_Sample-size
8