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document
A dose-response study of the effect of levobunolol on ocular hypertension . We conducted a randomized , double-masked , dose-response study of the ocular hypotensive effect of the beta-adrenergic blocker , levobunolol . A single drop of placebo or levobunolol ( at concentrations of 0.03 % , 0.3 % , 0.6 % , 1 % , and 2 % ) was administered to one eye of each of 48 patients with ocular hypertension . The 0.3 % and 0.6 % concentrations decreased intraocular pressure significantly from baseline levels compared to placebo at one , two , and four hours after treatment . The 1 % and 2 % concentrations decreased intraocular pressure significantly from baseline compared to placebo at one , two , four , six , eight , and 12 hours after administration . No objective or subjective side effects were noted , and no substantial changes in visual acuity , pupil diameter , pulse rate , or blood pressure were recorded during the study . These results appear to justify long-term studies of levobunolol for the treatment of increased intraocular pressure .
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Intervention_Pharmacological
levobunolol
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Intervention_Control
placebo
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Intervention_Pharmacological
levobunolol
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Intervention_Pharmacological
levobunolol
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Outcome_Physical
ocular hypertension .
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Outcome_Physical
ocular hypotensive effect
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Outcome_Physical
intraocular pressure
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Outcome_Physical
intraocular pressure significantly
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Outcome_Adverse-effects
objective or subjective side effects
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Outcome_Adverse-effects
substantial changes in visual acuity , pupil diameter , pulse rate , or blood pressure
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Outcome_Physical
intraocular pressure
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Participant_Sample-size
48
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Participant_Condition
ocular hypertension