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Arterial cardiovascular risk factors and venous thrombosis : results from a population-based , prospective study ( the HUNT 2 ) . BACKGROUND An explanation for the increased risk of myocardial infarction and stroke in patients with venous thrombosis is lacking . The objective of this study was to investigate whether risk factors for arterial cardiovascular disease also increase the risk of venous thrombosis . DESIGN AND METHODS Cases who had a first venous thrombosis ( n=515 ) and matched controls ( n=1,505 ) were identified from a population-based , nested , case-cohort study ( the HUNT 2 study ) comprising 71 % ( n=66,140 ) of the adult residents of Nord-Trøndelag County in Norway . RESULTS The age- and sex-adjusted odds ratio of venous thrombosis for subjects with concentrations of C-reactive protein in the highest quintile was 1.6 ( 95 % confidence interval : 1.2-2.2 ) compared to subjects with C-reactive protein in the lowest quintile . This association was strongest in subjects who experienced venous thrombosis within a year after blood sampling with a three-fold increased risk of participants in the highest versus the lowest quintile . Having first degree relatives who had a myocardial infarction before the age of 60 years was positively associated with venous thrombosis compared to not having a positive family history [ odds ratio 1.3 ( 95 % confidence interval : 1.1-1.6 ) ] . Subjects with blood pressure in the highest quintile had half the risk of developing venous thrombosis compared to subjects whose blood pressure was in the lowest quintile . There were no associations between the risk of venous thrombosis and total cholesterol , low density lipoprotein-cholesterol , high density lipoprotein-cholesterol , triglycerides , glucose or smoking . We confirmed the positive association between obesity and venous thrombosis . CONCLUSIONS C-reactive protein and a family history of myocardial infarction were positively associated with subsequent venous thrombosis . Blood pressure was inversely correlated to venous thrombosis . These findings should be confirmed by further investigations .
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Participant_Condition
patients with venous thrombosis