45326
document
Personalized smoking cessation : interactions between nicotine dose , dependence and quit-success genotype score . Improving and targeting nicotine replacement therapy ( NRT ) are cost-effective strategies for reducing adverse health consequences for smokers . Treatment studies document the efficacy of precessation NRT and support important roles for level of nicotine dependence and precessation smoking reduction in successful quitting . However , prior work has not identified the optimal precessation dose or means for personalizing NRT . Genome-wide association has identified groups of genomic markers associated with successful quitting , allowing us to develop a v1.0 " quit-success " genotype score . We now report influences of v1.0 quit-success genotype score , level of dependence and precessation smoking reduction in a smoking cessation trial that examined effects of 21 versus 42 mg/24 h precessation NRT . Four hundred seventy-nine smokers were randomized to 21 or 42 mg NRT , initiated 2 wks prior to target quit dates . We monitored self-reported abstinence and end-expired air carbon monoxide ( CO ) . Genotyping used Affymetrix arrays ( Santa Clara , CA , USA ) . The primary outcome was 10-wk continuous smoking abstinence . NRT dose , level of nicotine dependence and genotype scores displayed significant interactive effects on successful quitting . Successful abstinence also was predicted by CO reductions during precessation NRT . These results document ways in which smoking cessation strategies can be personalized based on levels of nicotine dependence , genotype scores and CO monitoring . These assessments , taken together , can help match most smokers with optimal NRT doses and help rapidly identify some who may be better treated using other methods .
45327
Intervention_Pharmacological
nicotine replacement therapy ( NRT )
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Intervention_Pharmacological
NRT
45329
Intervention_Pharmacological
NRT
45330
Intervention_Pharmacological
NRT
45331
Intervention_Pharmacological
NRT
45332
Intervention_Pharmacological
NRT
45333
Intervention_Pharmacological
NRT
45334
Outcome_Mental
v1.0 quit-success genotype score
45335
Outcome_Mental
level of dependence and precessation smoking reduction
45336
Outcome_Mental
self-reported abstinence
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Outcome_Other
end-expired air carbon monoxide ( CO )
45338
Outcome_Other
Affymetrix arrays
45339
Outcome_Mental
10-wk continuous smoking abstinence
45340
Outcome_Mental
NRT dose
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Outcome_Mental
level of nicotine dependence
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Outcome_Other
significant interactive effects
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Outcome_Mental
Successful abstinence
45344
Outcome_Other
CO reductions
45345
Outcome_Mental
levels of nicotine dependence
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Outcome_Other
genotype scores and CO monitoring