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document
The Randomised Intervention Treatment of Angina ( RITA ) Trial protocol : a long term study of coronary angioplasty and coronary artery bypass surgery in patients with angina . The Randomised Intervention Treatment of Angina ( RITA ) Trial is a prospective , randomised study to compare the short term and long term effects of percutaneous transluminal coronary angioplasty and coronary artery bypass surgery . During the study a register of patients undergoing coronary arteriography at the fourteen participating centres is being maintained to assess the overall context of patient recruitment . Patients with arteriographically proven coronary artery disease are considered for the trial if the participating cardiologist and surgeon agree that equivalent revascularisation could be achieved by either treatment method . Patients who satisfy the trial entry criteria are randomised to treatment by coronary angioplasty or coronary artery bypass surgery , with prospective stratification into groups with one , two , or three treatment vessels . Randomisation implies an intention to treat the patient by the assigned procedure and the analysis of long term results will include all randomised cases . The trial will recruit at least 1000 patients who will be followed for five years . The major trial end points include death , new myocardial infarction , and new coronary angioplasty or coronary artery bypass procedures . Other outcome measures include symptom and employment status , quality of life , exercise tolerance , and left ventricular function .
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Intervention_Surgical
coronary angioplasty
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Intervention_Surgical
coronary artery bypass surgery
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Intervention_Surgical
percutaneous transluminal coronary angioplasty
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Intervention_Surgical
coronary artery bypass surgery
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Intervention_Physical
coronary arteriography
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Intervention_Surgical
coronary angioplasty
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Intervention_Surgical
coronary artery bypass surgery
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Intervention_Physical
coronary angioplasty
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Intervention_Physical
coronary artery bypass procedures
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Outcome_Mortality
death
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Outcome_Physical
new myocardial infarction
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Outcome_Physical
new coronary angioplasty
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Outcome_Physical
coronary artery bypass procedures
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Outcome_Other
symptom and employment status
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Outcome_Other
quality of life
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Outcome_Physical
exercise tolerance
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Outcome_Physical
left ventricular function
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Participant_Condition
angina
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Participant_Condition
coronary arteriography
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Participant_Condition
arteriographically proven coronary artery disease
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Participant_Sample-size
1000