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document
Placebo-controlled clinical trial evaluating 9.5 % hydrogen peroxide high-adhesion whitening strips . OBJECTIVE To evaluate the effectiveness and tolerability of an experimental 9.5 % hydrogen peroxide whitening strip relative to a placebo control over a three-week period . METHODS In this parallel-design , double-blind clinical trial , 54 adult volunteers were randomized to an experimental 9.5 % hydrogen peroxide whitening strip or placebo strip balancing for age and baseline tooth color , and received treatment . Strips were worn on the maxillary arch 30 minutes daily for 20 days . Efficacy was measured objectively as L*a*b* color change from digital images at Days 4 , 7 , 15 , and 21 . RESULTS As early as Day 4 and at all subsequent visits , the 9.5 % strip group experienced significant ( p < 0.004 ) color improvement relative to placebo for b* and L* color parameters . The amount of color improvement increased with continuing peroxide strip use . Mean ± SE between-group differences in Ab* were -0.6 ± 0.16 , -0.8 ± 0.15 , -1.6 ± 0.19 , and -1.9 ± 0.20 at Days 4 , 7 , 15 , and 21 , respectively . Similar results were noted for AL* . Minor tooth sensitivity was the most common adverse event , as reported by 12 % of subjects in the 9.5 % strip group and 11 % of subjects in the placebo group . No subjects discontinued treatment due to an adverse event . CONCLUSION This placebo-controlled clinical trial demonstrated that an experimental 9.5 % hydrogen peroxide strip yielded significant tooth whitening relative to a placebo strip as early as after three days of product use .
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Intervention_Control
Placebo-controlled
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Intervention_Pharmacological
hydrogen peroxide high-adhesion whitening strips .
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Intervention_Pharmacological
hydrogen peroxide whitening strip
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Intervention_Control
placebo
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Intervention_Pharmacological
9.5 % hydrogen peroxide whitening strip or placebo strip
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Outcome_Physical
color improvement
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Outcome_Physical
color improvement
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Outcome_Other
Mean ± SE
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Outcome_Other
AL*
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Outcome_Adverse-effects
Minor tooth sensitivity