82743
document
Vitamin C and acute illness in Navajo school children . To evaluate earlier observations , including our own , showing usefulness of vitamin C for managing the common cold , we performed a double-blind trial of vitamin C versus placebo in 868 children . There was no difference in number becoming ill ( 133 versus 129 ) , number of episodes ( 166 versus 159 ) or mean illness duration ( 5.5 versus 5.8 days ) between the groups . Children receiving vitamin C had fewer throat cultures yielding beta-hemolytic streptococcus ( six versus 13 , P less than 0.10 ) , but no difference in overall complicated illness rate ( 24 versus 25 ) . Plasma ascorbic acid levels were higher in the vitamin group 24 to 26 hours after supplementation ( 1.28 versus 1.04 mg per 100 ml , P less than 0.01 ) . Children with high plasma ascorbic acid concentrations had longer mean illness ( 6.8 versus 4.0 days , P less than 0.05 ) than those with low levels . Vitamin C does not seem to be an effective prophylactic or therapeutic agent for upper respiratory illness .
82744
Intervention_Pharmacological
Vitamin C
82745
Intervention_Pharmacological
vitamin C
82746
Intervention_Pharmacological
vitamin C
82747
Intervention_Control
placebo
82748
Intervention_Pharmacological
Vitamin C
82749
Outcome_Physical
number becoming ill
82750
Outcome_Physical
number of episodes
82751
Outcome_Physical
mean illness duration
82752
Outcome_Physical
throat cultures
82753
Outcome_Physical
beta-hemolytic streptococcus
82754
Outcome_Physical
overall complicated illness rate
82755
Outcome_Physical
Plasma ascorbic acid levels
82756
Outcome_Physical
mean illness
82757
Participant_Condition
Navajo school children .