87493
document
A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media . Active chronic suppurative otitis media poses a management problem when patients are being considered for surgical treatment . Topical antibiotics have demonstrated varying degrees of success in the management of discharging ears . The introduction of quinolones has revived interest in these topical agents . This double-blind study compares two antibiotics , namely ofloxacin and neomycin-polymyxin B , with similar in vitro sensitivities to Gram positive and Gram negative organisms . Fifty-two patients were selected randomly and the results show that ofloxacin eardrops have marginal benefits in symptomatic improvement ( 89 per cent versus 79 per cent , p = 0.27 ) and bacterial eradication ( 81 per cent versus 75 per cent , p = 0.81 ) in active chronic suppurative otitis media . Significantly fewer patients ( seven per cent versus 29 per cent , p = 0.04 ) in the ofloxacin group had active disease at the end of the two-week treatment . We recommend the use of ofloxacin eardrops in managing active chronic suppurative otitis media since it has high clinical efficacy , contains no steroid component and has no demonstrated risk of ototoxicity .
87494
Intervention_Pharmacological
ofloxacin otic drops
87495
Intervention_Pharmacological
neomycin-polymyxin B-hydrocortisone otic drops
87496
Intervention_Pharmacological
antibiotics
87497
Intervention_Pharmacological
ofloxacin
87498
Intervention_Pharmacological
neomycin-polymyxin B
87499
Intervention_Pharmacological
ofloxacin eardrops
87500
Intervention_Pharmacological
ofloxacin eardrops
87501
Outcome_Physical
symptomatic improvement
87502
Outcome_Physical
bacterial eradication
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Outcome_Physical
active chronic suppurative otitis media
87504
Outcome_Adverse-effects
disease
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Outcome_Other
clinical efficacy
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Outcome_Adverse-effects
risk of ototoxicity
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Participant_Condition
chronic suppurative otitis media
87508
Participant_Condition
Active chronic suppurative otitis media
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Participant_Condition
discharging ears
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Participant_Sample-size
Fifty-two
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Participant_Condition
chronic suppurative otitis media
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Participant_Condition
active chronic suppurative otitis media