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document
[ Plasma separation combined with CVVHF in septic and SIRS patients ] . In a prospective non-randomized trial , 59 patients with sepsis ( n = 43 ) and SIRS ( n = 16 ) were treated on a surgical intensive care unit . In 22 patients plasmapheresis in combination with continuous venovenous hemofiltration ( CVVHF ) was administered . Lethality was 56 % in the sepsis group ; in the therapy group lethality was significantly lower in patients with plasmapheresis , even though in this population the organic failure rate was higher . Finally the dependency of lethality and age was similar in both groups . Lethality at 22 % in the plasmapheresis group with double organ failure was significantly lower ( P > 0.01 ) than in controls . Reduction of lethality seemed to be as high as 18 % in patients with sepsis , while patients with SIRS did not profit from the additional therapy . A prospective randomized trial in sepsis and double organic failure should be projected .
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Intervention_Pharmacological
Plasma separation
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Intervention_Pharmacological
CVVHF
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Intervention_Physical
plasmapheresis in combination with continuous venovenous hemofiltration ( CVVHF )
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Intervention_Pharmacological
plasmapheresis
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Outcome_Adverse-effects
Lethality
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Outcome_Physical
was
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Outcome_Adverse-effects
56 %
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Outcome_Physical
in the sepsis group
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Outcome_Mortality
lethality
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Outcome_Mental
the dependency of lethality and age was similar in both groups
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Outcome_Adverse-effects
Lethality
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Outcome_Physical
at
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Outcome_Adverse-effects
22 %
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Outcome_Physical
in the plasmapheresis group
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Outcome_Physical
double organ failure was significantly lower ( P > 0.01 ) than in controls
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Participant_Condition
septic and SIRS
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Participant_Sample-size
59
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Participant_Condition
sepsis
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Participant_Condition
SIRS
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Participant_Sample-size
22