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document
Treatments of preterm premature rupture of the membranes : a meta-analysis . The objective of this overview was to critically evaluate published randomized controlled trials on treatments in preterm premature rupture of the membranes . The Oxford data base on perinatal trials , MEDLINE , Excerpta Medica , and Index Medicus were searched . Through primary and secondary review with preset inclusion criteria , two independent judges identified 27 randomized controlled trials , of which 13 met inclusion criteria . The quality of these randomized controlled trials was scored . Five randomized controlled trials regarding antenatal use of corticosteroids to prevent respiratory distress syndrome could be combined meta-analytically and showed a reduction in respiratory distress syndrome in the treatment group ( p = 0.001 ) . However , no significant reduction in respiratory distress syndrome ( p = 0.286 ) was found after one study , with the lowest quality score , was excluded . A significant increase in endometritis and a trend toward an increase in neonatal infections and cesarean section rates were noted with treatment . Tocolysis , prophylactic antibiotics , and other interventions studied were not found to be of proved benefit and therefore should not be used outside of a randomized controlled trial .
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Intervention_Pharmacological
corticosteroids
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Intervention_Pharmacological
Tocolysis , prophylactic antibiotics
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Outcome_Physical
respiratory distress syndrome
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Outcome_Physical
respiratory distress syndrome
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Outcome_Physical
respiratory distress syndrome
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Outcome_Physical
endometritis
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Outcome_Physical
neonatal infections and cesarean section rates
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Participant_Condition
preterm premature rupture of the membranes :
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Participant_Condition
preterm premature rupture of the membranes .