77128
document
Interference on metabolism induced by muzolimine and chlorthalidone in type II hypertensive diabetics . There is a very high prevalence of hypertension in diabetic subjects , which makes it necessary to use an antihypertensive drug with the least possible metabolic interference . For example , in the early phase of hypertension , diuretics usually worsen the metabolic equilibrium . According to recent reports , a new diuretic , muzolimine ( MZ ) , which acts on the loop of Henle , seems to present a minor effect on carbohydrate metabolic balance . In order to determine whether this assumption was correct or not , we carried out a clinical trial on 26 type II ( non-insulin-dependent ) diabetics , in fairly good metabolic control and with moderate hypertension ( orthostatic diastolic pressure from 100 to 115 mmHg ) , comparing the effect of MZ with those of chlorthalidone ( CL ) . According to a randomized , single-blind cross-over design , the patients were treated with MZ ( 20 mg/day ) or CL ( 50 mg/day ) for the duration of 4 weeks . After the treatment period with the first drug , there was a 2 week wash-out period on placebo ( PL ) before the second drug was given . During the study , a set of metabolic and non-metabolic parameters was monitored , as were the clinostatic and orthostatic blood pressure values . The results show that the antihypertensive effect of the two drugs was the same ( both caused a more than 10 % decrease in systolic and diastolic blood pressure ) . No significant changes in plasma electrolyte levels occurred . There was a significant ( p less than 0.05 ) increase in urinary aldosterone excretion after CL ( 20.7 +/- 11 micrograms/24 hours vs. 13.3 +/- 8.5 after PL , and 14.5 +/- 7.2 after MZ ) ( mean values +/- standard deviations ) . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
muzolimine
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Intervention_Pharmacological
chlorthalidone
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Intervention_Pharmacological
antihypertensive drug
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Intervention_Pharmacological
muzolimine ( MZ )
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Intervention_Pharmacological
MZ
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Intervention_Pharmacological
chlorthalidone ( CL )
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Intervention_Pharmacological
MZ
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Intervention_Pharmacological
CL
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Intervention_Control
placebo
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Outcome_Physical
metabolic equilibrium
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Outcome_Physical
metabolic and non-metabolic parameters
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Outcome_Physical
clinostatic and orthostatic blood pressure values
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Outcome_Physical
antihypertensive effect
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Outcome_Physical
systolic and diastolic blood pressure
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Outcome_Physical
plasma electrolyte levels
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Outcome_Physical
urinary aldosterone excretion
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Participant_Condition
type II hypertensive diabetics .
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Participant_Condition
hypertension in diabetic subjects