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document
Clinical trial : marine lipid suppositories as laxatives . UNLABELLED Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory , anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases . We developed suppositories and ointment with 30 % free fatty acid ( FFA ) extract from omega-3 fish oil . Our purpose was to evaluate the safety of marine lipid suppositories and ointment in healthy volunteers and to explore the laxative effect of the suppositories . Thirty healthy volunteers were randomized either to a study group administrating 30 % FFA suppositories and applying 30 % FFA ointment to the perianal region twice per day for two weeks , or to a control group using placebo suppositories and ointment in a double blinded manner . RESULTS No serious toxic effects or irritation were observed . In the study group 93 % felt the urge to defecate after administration of the suppositories as compared to 37 % in the control group ( P = 0.001 ) . Subsequently 90 % in the study group defecated , compared to 33 % in the control group ( P = 0.001 ) . CONCLUSION The marine lipid suppositories and ointment were well tolerated with no significant toxic side effects observed during the study period . The suppositories have a distinct laxative effect and we aim to explore this effect in further clinical trials .
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Intervention_Pharmacological
marine lipid suppositories
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Intervention_Pharmacological
suppositories and ointment with 30 % free fatty acid ( FFA ) extract from omega-3 fish oil
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Intervention_Pharmacological
FFA suppositories
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Intervention_Pharmacological
FFA ointment
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Intervention_Control
placebo suppositories
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Outcome_Other
safety
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Outcome_Physical
laxative effect
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Outcome_Adverse-effects
serious toxic effects or irritation
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Outcome_Physical
urge to defecate
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Outcome_Physical
defecated
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Outcome_Adverse-effects
toxic side effects
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Outcome_Physical
laxative effect
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Participant_Condition
healthy volunteers