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document
Comparison of 0.25 % S ( - ) -bupivacaine with 0.25 % RS-bupivacaine for epidural analgesia in labour . We have compared the efficacy of 0.25 % S ( - ) -bupivacaine with 0.25 % RS-bupivacaine in providing epidural analgesia for labour in a randomized , multicentre , double-blind study . Analgesia was initiated with 10 ml of the study solution and maintained with 10-ml top-ups . We studied 137 women and treatments were found to be equivalent for onset , duration and quality of block . Median onset of pain relief was 12 min for both drugs and median duration was 49 ( range 3-129 ) min and 51 ( 7-157 ) min for S ( - ) -bupivacaine and RS bupivacaine , respectively . The estimated treatment difference for duration of pain relief was -4 ( 90 % CI -13 , 6 ) min . Thirty patients failed to achieve pain relief after the first injection ( 20 patients after S ( - ) -bupivacaine and 10 after RS-bupivacaine ; P = 0.039 ) . However , median duration of pain relief from the first top-up was 82 ( range 3-164 ) min for S ( - ) -bupivacaine and 76 ( 22-221 ) min for RS-bupivacaine . There were no significant differences in the quality of analgesia , as assessed by the investigators . There were no significant differences in the extent of sensory block , percentage of patients with motor block or incidence of adverse events .
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Intervention_Pharmacological
S ( - ) -bupivacaine
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Intervention_Pharmacological
RS-bupivacaine
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Outcome_Pain
analgesia
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Outcome_Pain
epidural analgesia
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Outcome_Pain
Median onset of pain relief
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Outcome_Pain
duration of pain relief
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Outcome_Pain
achieve pain relief
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Outcome_Pain
median duration of pain relief
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Outcome_Pain
quality of analgesia
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Outcome_Physical
sensory block , percentage of patients with motor block
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Outcome_Adverse-effects
or incidence of adverse events
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Participant_Condition
in labour .
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Participant_Sample-size
137
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Participant_Sex
women