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document
Influenza and pneumococcal vaccination as a model to assess C-reactive protein response to mild inflammation . This study was set up to examine whether an influenza vaccine or an influenza vaccine in combination with pneumococcal vaccine can be used as a model to study responses to mild stimulation of the inflammatory system . In this study , 19 subjects received the influenza vaccine , 20 subjects the combination of influenza and pneumococcal vaccine . CRP and prothrombin fragment 1 and 2 ( F1+2 ) were measured at baseline , and two times after vaccination . Influenza vaccination increased CRP by 0.20 mg/L , and influenza in combination with pneumococcal vaccine increased CRP by 0.60 mg/L . F1+2 increased 0.15 nmol/L after the combined vaccination ; an increase in response to the influenza vaccination was not statistically significant . Our findings show that the influenza vaccine alone as well as the combination of the influenza and pneumococcal vaccine increases CRP-levels with a peak 2 days after vaccination .
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Intervention_Pharmacological
vaccination
19496
Intervention_Pharmacological
influenza vaccine or an influenza vaccine in combination with pneumococcal vaccine
19497
Intervention_Pharmacological
influenza vaccine
19498
Intervention_Pharmacological
influenza and pneumococcal vaccine
19499
Intervention_Pharmacological
Influenza vaccination
19500
Intervention_Pharmacological
pneumococcal vaccine
19501
Intervention_Pharmacological
influenza vaccination
19502
Intervention_Pharmacological
influenza vaccine
19503
Intervention_Pharmacological
influenza and pneumococcal vaccine
19504
Outcome_Physical
CRP
19505
Outcome_Physical
prothrombin fragment 1 and 2 ( F1+2 )
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Outcome_Physical
CRP
19507
Outcome_Physical
CRP
19508
Outcome_Physical
F1+2
19509
Outcome_Physical
response to the influenza vaccination
19510
Outcome_Physical
CRP-levels
19511
Participant_Condition
mild inflammation .
19512
Participant_Sample-size
19
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Participant_Sample-size
20