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document
Twice-a-day versus four-times-a-day ofloxacin treatment of external ocular infection . PURPOSE The purpose of this study was to compare the efficacies of 0.3 % ofloxacin eyedrops , when given twice-a-day ( BID ) versus four-times-a-day ( QID ) , for the treatment of external ocular disease . METHOD Fifty patients with blepharitis , conjuctivitis , or blepharoconjunctivitis were randomly assigned to treatment with 0.3 % ofloxacin eyedrops , BID or QID , for 10 days . Signs , symptoms , and cultures were evaluated at the beginning and at the end of the study . RESULTS The clinical outcome was virtually identical in the two groups . There was a significant decrease in clinical scores in the BID and QID groups by days 3 to 5 ( 2.6-3.0 points ) and a further decrease by day 11 ( 4.3-5.0 points ) . There was no significant difference between the two groups at any time interval . Microbiologic studies showed a reduction in colony-forming units in 87 % of the BID group and in 80 % of the QID group . CONCLUSION The treatment of external ocular disease with 0.3 % ofloxacin eyedrops was equally effective when given BID or QID .
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Intervention_Pharmacological
0.3 % ofloxacin eyedrops , BID or QID , for 10 days
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Outcome_Other
efficacies
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Outcome_Other
clinical scores
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Outcome_Physical
colony-forming units
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Outcome_Physical
external ocular disease
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Outcome_Other
ofloxacin eyedrops was equally effective when given BID or QID
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Participant_Sample-size
Fifty
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Participant_Condition
blepharitis
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Participant_Condition
conjuctivitis
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Participant_Condition
blepharoconjunctivitis