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document
Does tetanus immune globulin interfere with the immune response to simultaneous administration of tetanus-diphtheria vaccine ? A comparative clinical trial in adults . In the management of wounds , sometimes it is recommended to give an adult-type tetanus-diphtheria ( Td ) vaccine dose plus tetanus immune globulin ( TIG ) . Sixty and 59 healthy young adults previously immunized against tetanus ( T ) and diphtheria ( D ) were randomized to receive intramuscularly either Td vaccine alone ( group 1 ) or Td vaccine plus 500 IU of TIG ( group 2 ) simultaneously . Antitoxin response was assessed after 4 weeks and 4 months . Circulating antibodies were measured by enzyme-linked immunosorbent assay ( ELISA ) . The cutoff of these tests was 0.1 IU/mL . Titers of 0.1 IU/mL or greater were considered protective . For geometric mean titers ( GMT ) , antibody titers below the cutoff of the assay were given , arbitrarily , 0.05 IU/mL . At 4 weeks , 98 % or more of the subjects in group 1 had circulating T and D antitoxin levels of 0.1 IU/mL or higher ; in group 2 , 95 % and 90 % of the subjects had titers above this limit for T and D , respectively . At 4 months , these percentages were 98 % and 95 % for T antitoxin levels in groups 1 and 2 , respectively ; whereas 96 % and 88 % of the subjects in groups 1 and 2 had D antitoxin levels of 0.1 IU/mL or higher , respectively . Significantly ( P < .05 ) higher GMTs were seen at the 4-week assessment ( but not at 4 months ) in group 1 , as compared with group 2 , in both T and D antitoxin levels ( 9.91 IU/mL versus 5.60 IU/mL for T antitoxin , and 2.86 IU/mL versus 1.45 IU/mL for D antitoxin ) . This finding resulted from those participants with low ( < 0.1 IU/mL ) prevaccination antibody titers . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
tetanus immune globulin
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Intervention_Pharmacological
tetanus-diphtheria vaccine
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Intervention_Pharmacological
tetanus-diphtheria ( Td ) vaccine
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Intervention_Pharmacological
tetanus immune globulin ( TIG )
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Intervention_Control
Td vaccine alone
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Intervention_Pharmacological
( group 1 )
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Intervention_Pharmacological
Td vaccine plus 500 IU of TIG
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Outcome_Physical
immune response
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Outcome_Physical
Antitoxin response
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Outcome_Physical
antibody titers
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Outcome_Physical
circulating T and D antitoxin levels
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Outcome_Physical
T antitoxin levels
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Outcome_Physical
D antitoxin levels
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Participant_Age
adults
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Participant_Sample-size
Sixty and 59
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Participant_Condition
healthy
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Participant_Age
young adults
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Participant_Condition
previously immunized against tetanus ( T ) and diphtheria ( D )