1963
document
The effect of Cys LT1 receptor blockade on airway responses to allergen . STUDY OBJECTIVE To evaluate the effect of a potent experimental leukotriene receptor antagonist , MK-571 , on airway responses to inhaled allergen . DESIGN Randomized , double-blind , placebo-controlled , crossover trial . SETTING Clinical research center . SUBJECTS Eight male volunteers with allergic asthma . INTERVENTIONS An intravenous loading dose was followed by an 8-hour infusion of MK-571 or placebo , with a 7- to 14-day washout between treatments . Allergen challenge was performed after the loading dose and a histamine challenge was performed before and 24 hours after allergen . MEASUREMENTS AND MAIN RESULTS Forced expiratory volume in 1 second was measured serially . MK-571 provided about 50 % protection during maximum early and late responses compared with placebo ( p=0.005 ) , but airway obstruction persisted 8-24 hours after allergen on both treatment days . Airway responsiveness to histamine was not significantly attenuated at 24 hours . CONCLUSION Blocking Cys LT1 receptors for 8 hours attenuated the early and late responses but did not interrupt the cascade of events leading to subsequent allergen-induced airway obstruction and hyperreactivity .
1964
Intervention_Physical
Cys LT1 receptor blockade
1965
Intervention_Pharmacological
leukotriene receptor antagonist , MK-571
1966
Intervention_Control
placebo-controlled
1967
Intervention_Pharmacological
8-hour infusion of MK-571
1968
Intervention_Pharmacological
placebo
1969
Intervention_Pharmacological
histamine
1970
Intervention_Pharmacological
MK-571
1971
Intervention_Control
placebo
1972
Outcome_Physical
Forced expiratory volume
1973
Outcome_Physical
airway obstruction
1974
Outcome_Other
Airway responsiveness
1975
Outcome_Physical
to
1976
Outcome_Other
histamine
1977
Participant_Sample-size
Eight
1978
Participant_Sex
male
1979
Participant_Condition
allergic asthma