51482
document
Effect of prophylactic amiodarone in patients with rheumatic valve disease undergoing valve replacement surgery . The study was carried out to evaluate the effect of prophylactic single-dose intravenous amiodarone in patients undergoing valve replacement surgery . Maintenance of sinus rhythm is better than maintenance of fixed ventricular rate in atrial fibrillation ( AF ) especially in the presence of irritable left or right atrium because of enlargement . Fifty-six patients with valvular heart disease with or without AF were randomly divided into two groups . Group I or the amiodarone group ( n=28 ) received amiodarone ( 3 mg/kg in 100 ml normal saline ) and group II or the control group received same volume of normal saline . The standardized protocol for cardiopulmonary bypass was maintained for all the patients . AF occurred in 7.14 % patients in group I , and in group II , 28.57 % ( P=0.035 ) ; ventricular tachycardia/fibrillation was observed in 21.43 % patients in group I and 46.43 % patients in group II ( P=0.089 ) after release of aortic clamp . Most of the patients in group I ( 92.86 % ) maintained sinus rhythm without cardioversion or defibrillation after release of aortic cross clamp ( P=0.002 ) . Defibrillation or cardio version was needed in 7.14 % patients in group I and 28.57 % patients in group II ( P=0.078 ) . A single prophylactic intraoperative dose of intravenous amiodarone decreased post bypass arrhythmia in this study in comparison to the control group . Single dose of intraoperative amiodarone may be used to decrease postoperative arrhythmia in open heart surgery .
51483
Intervention_Pharmacological
prophylactic amiodarone
51484
Intervention_Pharmacological
amiodarone
51485
Intervention_Pharmacological
amiodarone group
51486
Intervention_Pharmacological
amiodarone
51487
Intervention_Pharmacological
normal saline
51488
Intervention_Pharmacological
amiodarone
51489
Intervention_Pharmacological
amiodarone
51490
Outcome_Physical
ventricular tachycardia/fibrillation
51491
Outcome_Physical
sinus rhythm without cardioversion or defibrillation
51492
Outcome_Physical
Defibrillation or cardio version
51493
Outcome_Physical
post bypass arrhythmia
51494
Participant_Age
Fifty-six patients with valvular heart disease with or without AF were randomly divided