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document
Oral desensitization in papular urticaria in children . Papular urticaria ( PU ) is among the commonest skin ailments in children . Induced specific desensitization to insect bites is theoretically an effective means of prevention of PU . In this double blind placebo controlled study , an oral vaccine prepared from insect saliva was compared with placebo ( stable vaccine solvent ) . Vaccine and placebo effectiveness were tested by counting active PU lesions , serum eosinophils , and IgE , before and after 4 months of treatment . Statistically significant differences between oral vaccine and placebo were not found in the clinical or the immunological variables tested . We conclude that , although a lack of oral vaccine efficacy was suspected , larger study samples are needed to strengthen our conclusion .
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Intervention_Control
placebo
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Intervention_Pharmacological
oral vaccine prepared from insect saliva
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Intervention_Control
placebo ( stable vaccine solvent ) .
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Intervention_Pharmacological
Vaccine
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Intervention_Control
placebo
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Outcome_Physical
counting active PU lesions
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Outcome_Physical
serum eosinophils
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Outcome_Physical
IgE
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Participant_Condition
papular urticaria in
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Participant_Age
children
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Participant_Condition
. Papular urticaria