1546
document
Treatment of hypertensive and hypercholesterolaemic patients in general practice . The effect of captopril , atenolol and pravastatin combined with life style intervention . OBJECTIVE To elucidate the effect on blood pressure and blood lipids of an angiotensin converting enzyme inhibitor ( captopril ) , and a beta-receptor blocking agent ( atenolol ) , given alone or in combination with a cholesterol reducing drug , the beta-hydroxy-methylglutaryl-coenzyme A reductase inhibitor pravastatin , in patients who were also encouraged to improve their lifestyle . DESIGN A longitudinal study consisting of three phases . I : Lifestyle intervention alone . II : Continued lifestyle intervention combined with captopril or atenolol . III : Continued lifestyle intervention combined with the same drugs as in phase II and in addition pravastatin or placebo . SETTING Fifty-four general practice surgeries in Norway . PARTICIPANTS Hypertensive patients , 210 females and 160 males , treated or untreated with antihypertensive drugs with a sitting diastolic blood pressure between 95 and 115 mmHg and a serum total cholesterol between 6.5 mmol/l ( 7.0 for those age 60-67 years ) and 9.0 mmol/l . RESULTS The antihypertensive effect of captopril and atenolol was not influenced by concurrent administration of pravastatin . The effect of pravastatin was not limited by concurrent medication with captopril or atenolol . Improvement in lifestyle seemed to reduce the need for supplementary treatment with diuretics . CONCLUSION Pravastatin can be used in combination with captopril or atenolol in the treatment of hypertensive and hypercholesterolaemic patients .
1547
Intervention_Pharmacological
captopril
1548
Intervention_Pharmacological
atenolol
1549
Intervention_Pharmacological
pravastatin combined with life style intervention
1550
Intervention_Pharmacological
angiotensin converting enzyme inhibitor ( captopril )
1551
Intervention_Pharmacological
beta-receptor blocking agent ( atenolol )
1552
Intervention_Pharmacological
cholesterol reducing drug
1553
Intervention_Pharmacological
beta-hydroxy-methylglutaryl-coenzyme A reductase inhibitor pravastatin
1554
Intervention_Educational
were also encouraged to improve their lifestyle
1555
Intervention_Educational
Lifestyle intervention alone
1556
Intervention_Pharmacological
Continued lifestyle intervention combined with captopril or atenolol
1557
Intervention_Pharmacological
Continued
1558
Intervention_Other
lifestyle intervention combined with the same drugs as in phase II
1559
Intervention_Pharmacological
pravastatin
1560
Intervention_Other
placebo
1561
Intervention_Pharmacological
captopril
1562
Intervention_Pharmacological
atenolol
1563
Intervention_Pharmacological
pravastatin
1564
Intervention_Pharmacological
pravastatin
1565
Intervention_Pharmacological
captopril
1566
Intervention_Pharmacological
atenolol
1567
Intervention_Pharmacological
diuretics
1568
Intervention_Pharmacological
Pravastatin
1569
Intervention_Pharmacological
captopril
1570
Intervention_Pharmacological
atenolol
1571
Outcome_Mental
Improvement in lifestyle
1572
Outcome_Other
supplementary treatment with diuretics