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document
Intravenous lipid emulsion improves recovery time and quality from isoflurane anaesthesia : a double-blind clinical trial . Recovery time and quality after general anaesthesia is important for patient safety . This study aimed to determine whether intravenous lipid emulsion could improve recovery profiles from isoflurane anaesthesia in adult patients undergoing laparoscopic cholecystectomy . Sixty-six patients were enrolled . After anaesthesia induction , inspired isoflurane concentration was adjusted to maintain stable vital signs and the suitable conditions for operation . At the end of the operation , the isoflurane was discontinued , and either 2 ml/kg 30 % lipid emulsions or 0.9 % saline solution was administered intravenously . The time to eye opening , extubation and exit from the operation room was recorded , and the quality of recovery from anaesthesia was assessed . Sixty patients completed the study . The median time to eye opening and exit from the operation room was significantly shorter in the lipid emulsion group than in the saline group [ 15.5 ( interquartile range 9.0 ) versus 20.0 ( 10.0 ) min. , p = 0.01 ; 19.5 ( 8.3 ) versus 23.6 ( 6.3 ) min. , p = 0.04 , respectively ] , whereas the median time to extubation did not show any noticeable difference . The quality of recovery was better in the lipid emulsion group than that of the saline solution group with respect to drowsiness visual analogue scale score ( p < 0.01 ) , Observer 's Assessment of Alertness/Sedation score ( p < 0.01 ) , Mini-Mental State Examination score ( p = 0.04 ) and Modified Aldrete Post Anaesthesia Recovery score ( p = 0.03 ) . No serious adverse events were observed during the study period . In conclusion , intravenous lipid emulsion may effectively improve the recovery time and quality from isoflurane anaesthesia for laparoscopic cholecystectomy .
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Intervention_Pharmacological
Intravenous lipid emulsion
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Intervention_Pharmacological
isoflurane anaesthesia :
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Intervention_Pharmacological
intravenous lipid emulsion
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Intervention_Pharmacological
isoflurane anaesthesia
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Intervention_Pharmacological
isoflurane
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Intervention_Pharmacological
lipid emulsions
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Intervention_Pharmacological
saline solution
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Intervention_Pharmacological
lipid emulsion
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Intervention_Pharmacological
isoflurane anaesthesia
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Participant_Age
adult
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Participant_Condition
laparoscopic cholecystectomy
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Participant_Sample-size
Sixty-six
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Participant_Sample-size
Sixty patients