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document
Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain . BACKGROUND Different methods and propofol formulations have been used to decrease propofol injection pain , but it remains an unresolved problem . We aimed to investigate the effect of i.v . acetaminophen pretreatment on the propofol injection pain . METHODS One hundred and fifty ASA I-II patients undergoing general anaesthesia were randomly allocated into three groups . A 20-gauge catheter was inserted into a superficial radial vein of the left hand , and after the occlusion of venous drainage , Groups I , II , and III were pretreated with 40 mg of lidocaine in saline , 50 mg of i.v . acetaminophen , and 5 ml of saline , respectively . The occlusion was released after 2 min and one-fourth of the total propofol dose was injected into the vein over a period of 5 s. During the injection of both pretreatment solution and propofol , patients ' pain was assessed and recorded as 0-3 , corresponding to no , mild , moderate or severe pain , respectively . Chi2 and Kruskal-Wallis tests were used for the statistical analysis . For all analyses , differences were considered to be significant at P < 0.05 . RESULTS Patient characteristics were similar among the groups . Incidence of pain on injection of propofol in control , i.v . acetaminophen , and lidocaine groups was 64 % , 22 % and 8 % , respectively ( P < 0.05 ) . CONCLUSIONS Pretreatment with i.v . acetaminophen seems to be effective in attenuating pain during i.v . injection of propofol .
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Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
33228
Intervention_Pharmacological
acetaminophen
33229
Intervention_Control
saline
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Intervention_Pharmacological
propofol
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Intervention_Pharmacological
propofol
33232
Intervention_Pharmacological
acetaminophen
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
acetaminophen
33235
Intervention_Pharmacological
propofol .
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Outcome_Other
Efficacy
33237
Outcome_Pain
propofol injection pain
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Outcome_Pain
injection pain
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Outcome_Pain
pain
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Outcome_Pain
Incidence of pain on injection
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Outcome_Pain
pain
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Participant_Condition
One hundred and fifty ASA I-II patients undergoing general anaesthesia