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document
[ Perioperative teicoplanin prophylaxis in patients undergoing breast reconstruction with the abdominal wall . A case-control study ] . The authors report the results of a randomized clinical trial of antibiotic prophylaxis of postoperative infection following breast reconstruction by transposition of rectus abdominis myocutaneous flap ( TRAMF ) . The aim was to evaluate the efficacy and tolerability of a short-term parenteral prophylaxis with Teicoplanin and the end-point of the study was the evaluation of wound contamination assessed by means of microbiologic culture of drainage fluid . From October 1990 to March 1992 38 patients were recruited : 20 patients in the antibiotic prophylaxis arm and 18 patients in the control group . Analysis of drainage fluids showed a higher contamination rate ( 15/18 = 83 % ) in the control group as compared to the prophylaxis arm ( 2/20 = 10 % ) ( p < 0.0001 ) . Moreover , 11 patients in the control arm suffered from fever > 37.5 degrees C for at least 3 days as compared to 1 patient in the antibiotic prophylaxis group ; the postoperative stay was 13.3 +/- 4.3 and 9.0 +/- 1.6 in the control and antibiotic arm respectively . No antibiotic related side effects were evidenced through the study . These results seem to confirm the value of parenteral short-term antibiotic prophylaxis of postoperative infection in such kind of " clean " operative procedure .
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Intervention_Pharmacological
teicoplanin prophylaxis
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Intervention_Pharmacological
parenteral prophylaxis with Teicoplanin
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Outcome_Physical
higher contamination rate
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Outcome_Adverse-effects
fever > 37.5 degrees C
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Outcome_Other
postoperative stay
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Outcome_Adverse-effects
antibiotic related side effects