84272
document
[ A controlled study of treating haemophilia A on an out-patient basis ( author 's transl ) ] . For six months 36 U factor VIII concentrates per kg bodyweight and week were administered to six out-patients with severe haemophilia A . The injection regimen was changed in every patient every two months , from 36 U/kg once to 18 U/kg twice and 12 U/kg three times , intravenously . The six possible combinations of these three dosage schedules were used in the patients in a strictly randomised manner , and all patients were treated during the same period . In the pre-trial period ( treatment as needed ) there were an average of 35 bleedings per two months . On continual treatment there were 21 bleedings on weekly injections of 36 U factor VIII per kg , 14 on twice weekly 18 U/kg and none on 12 U/kg , three times weekly . The differences are statistically significant . The absence of bleeding on the last dosage schedule was achieved during normal working . Days lost from work per patient per month was zero on three times 12 U/kg , 0.4 day on twice 18 U/kg and once 36 U/kg , while it had been five days in the pre-trial period . In addition to freedom from bleeding and no lost days from work , there was increased mobility and physical capacity .
84273
Intervention_Pharmacological
36 U factor VIII concentrates
84274
Outcome_Physical
bleedings
84275
Outcome_Physical
absence of bleeding
84276
Outcome_Other
Days lost from work per patient per month
84277
Outcome_Physical
freedom from bleeding
84278
Outcome_Physical
lost days
84279
Outcome_Physical
mobility and physical capacity .
84280
Participant_Sample-size
six
84281
Participant_Condition
haemophilia A