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document
Deslorelin implants in pre-pubertal female dogs : short- and long-term effects on the genital tract . Deslorelin acetate is a GnRH agonist used for contraception in dogs . This study aimed to evaluate the treatment of pre-pubertal female dogs with deslorelin acetate implants , to better investigate the primary stimulatory effect of the drug and the long-term effects on the genital tract , throughout repeated treatments . Sicilian hound female dogs ( 24 ) were randomly assigned to treated group , control group 1 and control group 2 . First group bitches were implanted at 4.5 , 9.0 and 13.5 months and monitored clinically , ultrasonographically and endocrinologically , throughout the study period ( 13.5 months ) . Control group 1 bitches were not implanted and clinically monitored for the same period . At 18 months , the animals underwent ovariohysterectomy , thus allowing evaluation of the internal genitalia . Control group 2 bitches were ovariohysterectomized at the age of 4.5 months . The suppression of oestrus was obtained in the treated group despite the fact that the first implant caused a modest increase in plasmatic levels of 17-beta estradiol and an evident cornification of the vaginal mucosa cells ( 50-80 % ) . Estradiol and progesterone were at baseline levels for the remaining study period , in which no other oestrous manifestations were observed . The external genitalia maintained a juvenile appearance . The ovaries , ultrasonographically , showed no follicular structures and stayed the same size . At 18 months , the genital tract was still juvenile with inactive small ovaries and a thin filiform uterus . Deslorelin suppressed ovarian activity in pre-pubertal bitches , and oestrous induction was not observed despite the presence of the primary stimulatory effect of the drug . Juvenile genitalia were an expected side effect of the treatment .
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Intervention_Physical
Deslorelin implants
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Intervention_Pharmacological
Deslorelin acetate
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Intervention_Physical
deslorelin acetate implants
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Intervention_Other
not implanted
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Intervention_Physical
ovariohysterectomy
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Outcome_Physical
primary stimulatory effect
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Outcome_Physical
evaluation of the internal genitalia .
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Outcome_Physical
suppression of oestrus
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Outcome_Physical
plasmatic levels of 17-beta estradiol
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Outcome_Physical
cornification of the vaginal mucosa cells
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Outcome_Physical
Estradiol and progesterone
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Outcome_Physical
suppressed ovarian activity
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Outcome_Physical
oestrous induction was not observed
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Outcome_Physical
Juvenile genitalia
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Participant_Age
pre-pubertal
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Participant_Sex
female
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Participant_Age
pre-pubertal
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Participant_Sex
female
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Participant_Condition
deslorelin acetate implants
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Participant_Sex
female
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Participant_Sample-size
24