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document
Deficiency of serum ionized magnesium in patients receiving hemodialysis or peritoneal dialysis . Serum total magnesium ( TMg ) measurements in dialysis patients are variable , with some groups reporting hypermagnesemia and some hypomagnesemia . It had not been possible to measure the biologically active fraction , ionized magnesium ( IMg2+ ) . The authors utilized an ion-selective electrode to measure IMg in 26 hemodialysis patients and 10 peritoneal dialysis ( CAPD ) patients and compared the results with those from 66 age matched control subjects . Dialysate magnesium was 0.375 mM/L for the hemodialysis and 0.25 mM/L for the CAPD patients . When compared with control subjects , both hemodialysis and CAPD patients had significantly lower IMg2+ ( 0.55 +/- 0.02 and 0.50 +/- 0.02 vs. 0.60 +/- 0.004 mM/L ; p < 0.05 ) and greater or normal TMg values ( 0.99 +/- 0.04 , different at the p < 0.001 level , and 0.85 +/- 0.04 vs. 0.84 +/- 0.008 ) . Ionized calcium ( ICa2+ ) values were similar for all three groups ( 1.15 +/- 0.02 and 1.21 +/- 0.04 vs. 1.17 +/- 0.01 ) , resulting in increased mean ICa2+/IMg2+ ratios ( 2.14 +/- 0.07 and 2.42 +/- 0.06 vs. 1.95 +/- 0.02 for the control subjects ; p < 0.05 ) . The percent of total magnesium that was ionized ( % IMg2+ ) was low in both the hemodialysis and CAPD patients ( 55.6 +/- 0.93 and 59.2 +/- 1.05 ) compared with that of control subjects ( 72 +/- 0.61 ; p < 0.05 ) . IMg2+ values correlated with TMg values in both hemodialysis ( r = 0.93 ; p < 0.0001 ) and CAPD ( r = 0.92 ; p < 0.0001 ) patients did not correlate with age , time on dialysis , weight , fasting cholesterol or triglyceride , albumin , blood urea nitrogen ( BUN ) , creatinine , hematocrit , phosphate , or PTH values . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
Dialysate magnesium
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Outcome_Physical
Deficiency of serum ionized magnesium
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Outcome_Physical
IMg
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Outcome_Physical
IMg2+
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Outcome_Physical
greater or normal TMg values
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Outcome_Physical
Ionized calcium ( ICa2+ ) values
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Outcome_Physical
ICa2+/IMg2+ ratios
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Outcome_Physical
ionized ( % IMg2+ )
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Participant_Condition
patients receiving hemodialysis or peritoneal dialysis
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Participant_Condition
dialysis
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Participant_Sample-size
26
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Participant_Condition
hemodialysis
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Participant_Sample-size
10
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Participant_Condition
peritoneal dialysis ( CAPD )
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Participant_Sample-size
66