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document
Surrogate and auxiliary endpoints in clinical trials , with potential applications in cancer and AIDS research . Surrogate endpoints have been defined by Prentice as response variables that can substitute for a 'true ' endpoint for the purpose of comparing specific interventions or treatments in a clinical trial . The applicability of this definition , and of related surrogate endpoint criteria , is discussed , with emphasis on cancer and AIDS research settings . Auxiliary endpoints are defined as response variables , or covariates , that can strengthen true endpoint analyses . Specifically , such response variables provide some additional information on true endpoint occurrence times for study subjects having censored values for such times . Auxiliary variables will very frequently be available , and they may be able to be used without making additional strong assumptions . Approaches to the use of auxiliary variables using ideas based on augmented score and augmented likelihood methods are described .
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Intervention_Physical
Surrogate
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Intervention_Physical
auxiliary endpoints
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Intervention_Physical
Surrogate endpoints
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Intervention_Physical
Auxiliary endpoints
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Intervention_Physical
Auxiliary variables
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Intervention_Physical
auxiliary variables
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Participant_Condition
AIDS
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Participant_Condition
cancer
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Participant_Condition
AIDS