93635
document
[ Intra-arterial ( 5-FU/FA and FUDR ) versus systemic chemotherapy ( 5-FU/FA ) of non-resectable colorectal liver metastases ] . The relative efficacy of HAI FUDR , HAI 5-FU/FA , and i.v . 5-FU/FA chemotherapy for the treatment of unresectable colorectal liver metastases was compared in a prospective randomized clinical trial . The response rate after HAI treatment was significantly higher as compared to i.v . treatment with no statistical benefit regarding survival and time to progression . HAI FUDR treatment was inferior as compared to HAI or i.v . 5-FU/FA . i.v . 5-FU/FA-therapy is therefore the method of choice outside clinical trials .
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Intervention_Pharmacological
Intra-arterial ( 5-FU/FA
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Intervention_Physical
and
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Intervention_Pharmacological
FUDR
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Intervention_Physical
)
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Intervention_Pharmacological
systemic chemotherapy ( 5-FU/FA )
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Intervention_Pharmacological
HAI FUDR
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Intervention_Physical
,
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Intervention_Pharmacological
HAI 5-FU/FA
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Intervention_Physical
, and
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Intervention_Pharmacological
i.v . 5-FU/FA chemotherapy
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Intervention_Pharmacological
HAI
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Intervention_Pharmacological
HAI FUDR
93648
Intervention_Pharmacological
HAI
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Intervention_Pharmacological
5-FU/FA .
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Intervention_Pharmacological
5-FU/FA-therapy
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Outcome_Physical
non-resectable colorectal liver metastases
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Outcome_Other
relative efficacy
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Outcome_Other
response rate
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Outcome_Mortality
survival
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Outcome_Physical
time to progression
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Outcome_Other
inferior
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Participant_Condition
non-resectable colorectal liver metastases