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document
Comparison of fluoxetine and placebo in the treatment of obesity . Our study aims at assessing the efficacy and safety of fluoxetine as compared with placebo in the treatment of obesity using a double-blind crossover design . We studied 42 obese women ( body mass index 35.9 +/- 5.3 kg/m2 ) . The obese patients were randomized to start treatment with fluoxetine ( group A ) or placebo ( group B ) for 3 months ( period 1 ) . After a 1-month washout period , treatment was crossed for the following 3 months ( period 2 ) . There was no significant difference in weight loss when the patients were treated with fluoxetine ( group A period 1 and group B period 2 ) as compared with patients treated with placebo ( group B period 1 and group A period 2 ) . There were no significant differences in monthly weight reduction during both treatments . In conclusion , we demonstrated that serotoninergic drugs such as fluoxetine need further investigation before being used indiscriminately in obese subjects .
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Intervention_Pharmacological
fluoxetine
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Intervention_Control
placebo
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Intervention_Pharmacological
fluoxetine
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Intervention_Control
placebo
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Intervention_Pharmacological
fluoxetine
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Intervention_Control
placebo
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Intervention_Pharmacological
fluoxetine
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Intervention_Control
placebo
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Intervention_Pharmacological
fluoxetine
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Outcome_Physical
obesity .
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Outcome_Physical
weight loss
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Outcome_Physical
monthly weight reduction
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Participant_Condition
obesity .
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Participant_Sample-size
42