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document
The effects of prophylactic management and therapeutics on hypertensive disease in pregnancy : preliminary studies . A controlled prospective evaluation of pregnancy complicated by chronic hypertension is proposed and preliminary data on population selection and pregnancy outcome are presented . Sixty-three women with evidence of underlying hypertensive disease were followed prospectively throughout pregnancy . Twenty-three patients were followed in a protocol of intensified prenatal care and randomized assignment of antihypertensive agents : placebo , hydralazine , or methyldopa . Forty patients were followed in the high-risk pregnancy clinics at Duke University . The incidence of preeclampsia in the randomized prophylactic antihypertensive group was statistically lower than that in the nonrandomized group ( 8.7 versus 32.5 % ; P less than .01 ) . There were no other statistically significant differences between the groups . The 63 hypertensive women had a high incidence of diabetes mellitus diagnosed during pregnancy ( 49.2 % ) as compared to the authors ' general obstetric population ( 8.1 % ) .
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Intervention_Psychological
prophylactic management and therapeutics
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Intervention_Pharmacological
antihypertensive agents : placebo , hydralazine , or methyldopa
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Outcome_Adverse-effects
effects
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Outcome_Physical
hypertensive disease
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Outcome_Other
population selection
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Outcome_Physical
incidence of preeclampsia
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Outcome_Physical
diabetes mellitus
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Participant_Condition
hypertensive disease
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Participant_Sample-size
Sixty-three
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Participant_Sex
women
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Participant_Condition
hypertensive disease
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Participant_Sample-size
Forty
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Participant_Sample-size
63
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Participant_Condition
hypertensive