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document
Chemotherapy of large bowel carcinoma -- fluorouracil ( FU ) + hydroxyurea ( HU ) vs. methyl-CCNU , oncovin , fluorouracil , and streptozotocin ( MOF-Strep ) . An Eastern Cooperative Oncology Group study . In this prospective randomized study of initial chemotherapy for advanced measurable metastatic large bowel carcinoma , the response rate was 6/32 ( 19 % ) for FU + HU and 5/32 ( 16 % ) for MOF-Strep ; the estimated median survival is 43 weeks for both treatments . Patients who received MOF-Strep experienced substantially greater vomiting and hematologic toxicity than patients who received FU + HU ( p less than 0.001 ) .
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Intervention_Pharmacological
fluorouracil ( FU ) + hydroxyurea ( HU )
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Intervention_Pharmacological
methyl-CCNU , oncovin , fluorouracil , and streptozotocin ( MOF-Strep )
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Outcome_Physical
bowel carcinoma
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Outcome_Physical
response rate
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Outcome_Mortality
median survival
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Outcome_Adverse-effects
vomiting and hematologic toxicity
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Participant_Condition
large bowel carcinoma
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Participant_Condition
advanced measurable metastatic large bowel carcinoma