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The effects of a six-week supervised multimodal exercise intervention during chemotherapy on cancer-related fatigue . PURPOSE Cancer related fatigue ( CRF ) is a common problem for cancer patients across diagnoses during chemotherapy and is associated with physical inactivity , lower functional level and lack of energy . Few RCT exercise intervention studies have included cancer patients undergoing chemotherapy . The objective of this study is to evaluate whether a six-week supervised multimodal exercise intervention , adjunct to chemotherapy and standard care , can reduce the patient 's CRF level . METHODS Data is based on analyses of a prospective randomised controlled trial 'The Body & Cancer Trial ' . 213 cancer patients with different diagnoses were randomised into an intervention group or wait-list control group . The primary outcome , Fatigue score ( CRF ) , was evaluated by the Functional Assessment of Cancer Therapy-Anaemia Questionnaire ( FACT-An- ) ( FACT-G score & FACT-An Anemia subscale ) . INTERVENTION Supervised exercise , comprising high-intensity cardiovascular and heavy resistance training , relaxation- and body awareness training and massage , 9 h weekly for 6 weeks . RESULTS CRF was significantly reduced in the intervention group , corresponding to a Fatigue score reduction of 3.04 ( effect size of 0.44 , 95 % CI 0.17-0.72 ) ( P = .002 ) , the FACT-An score by 5.40 ( P = .015 ) , the FACT-An Toi score by 5.22 ( P = .009 ) and the Anaemia-ANS by 3.76 ( P = .002 ) . There was no statistically significant effect on the General Quality of Life score ( FACT-G ) or on any of the individual wellbeing scores ; Physical ( P = .13 ) , Emotional ( P = .87 ) , Social ( P = .83 ) and Functional ( P = .26 ) . CONCLUSION In summary , this six-week supervised multimodal exercise intervention can lead to significant reduction in self-reported CRF in cancer patients undergoing chemotherapy .
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Intervention_Physical
multimodal exercise intervention
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Intervention_Physical
chemotherapy
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Intervention_Physical
chemotherapy
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Intervention_Physical
exercise intervention
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Intervention_Physical
supervised multimodal exercise intervention
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Intervention_Physical
adjunct to chemotherapy and standard care
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Intervention_Physical
intervention group
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Intervention_Control
wait-list control group
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Intervention_Physical
Supervised exercise , comprising high-intensity cardiovascular and heavy resistance training , relaxation- and body awareness training and massage
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Intervention_Physical
supervised multimodal exercise intervention
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Outcome_Physical
cancer-related fatigue
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Outcome_Physical
Cancer related fatigue ( CRF )
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Outcome_Physical
CRF level
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Outcome_Physical
Fatigue score ( CRF )
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Outcome_Physical
Functional Assessment of Cancer Therapy-Anaemia Questionnaire ( FACT-An- ) ( FACT-G score & FACT-An Anemia subscale )
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Outcome_Physical
CRF
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Outcome_Physical
Fatigue score reduction
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Outcome_Physical
FACT-An score
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Outcome_Physical
FACT-An Toi
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Outcome_Physical
Anaemia-ANS
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Outcome_Other
General Quality of Life score
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Outcome_Physical
individual wellbeing scores ; Physical
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Outcome_Physical
Emotional
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Outcome_Physical
Social
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Outcome_Physical
Functional
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Outcome_Physical
self-reported CRF
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Participant_Condition
cancer-related fatigue .
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Participant_Condition
into