35960
document
The effect of intravenous lidocaine on QT changes during tracheal intubation . Laryngoscopy and tracheal intubation may provoke changes of cardiac repolarisation . The aim of this study was to assess the effect of intravenous lidocaine on the ECG changes induced by laryngoscopy and tracheal intubation . Forty-three female patients were randomly allocated to receive lidocaine ( 1.5 mg.kg ( -1 ) ) or placebo immediately after induction of anaesthesia and changes in the ECG and arterial blood pressure were recorded . Correction of QT interval was calculated using Bazett 's formula ( QTcb ) , Fridericia 's correction ( QTcf ) , and Framingham formula ( QTcF ) . Transmural dispersion of repolarisation ( TDR ) was determined as Tpeak-Tend time . There were no changes in the QTc value in the lidocaine group . In the placebo group , significant increases in QTcb , QTcf and QTcF values were observed after intubation compared to either control measurements or to comparative measurements in the lidocaine group . There were no significant differences in TDR either between or within the groups . Lidocaine diminishes prolongation of QTc , induced by tracheal intubation but there is no effect of intubation on TDR .
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
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Intervention_Control
placebo
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
placebo
35967
Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
Lidocaine
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Outcome_Physical
QT changes
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Outcome_Physical
cardiac repolarisation
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Outcome_Physical
ECG changes
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Outcome_Physical
ECG and arterial blood pressure
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Outcome_Physical
QT interval
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Outcome_Physical
Transmural dispersion of repolarisation ( TDR )
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Outcome_Physical
QTc value
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Outcome_Physical
QTcb , QTcf and QTcF values
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Outcome_Physical
TDR
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Outcome_Physical
QTc
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Outcome_Physical
TDR
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Participant_Condition
tracheal intubation
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Participant_Condition
laryngoscopy
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Participant_Condition
tracheal intubation
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Participant_Sample-size
Forty-three
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Participant_Sex
female