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document
[ Study on safety and immunogenicity of oral poliomyelitis attenuated live vaccine ( human diploid cell ) ] . OBJECTIVE To evaluate the safety and Immunogenicity of the Poliomyelitis vaccine ( Human Diploid Cell ) in > or =2 month-old children . METHODS A random , blind and control trial , 1200 healthy children of 2-5 months old in Jiangsu province were administered OPV ( HDC ) vaccine and control vaccines . The antibody was tested by neutralization test . RESULTS After 3 doses of the OPV ( HDC ) vaccine , the systemic reactions were mild . After 1 month of vaccination with 3 doses of the OPV ( HDC ) vaccine , the immune success rates of I , II , III type were 98.28 % , 99.45 % , and 95.71 % respectively , the GMTs of I , II , III type in susceptible children were 1:1243.72 , 1:234.38 and 1:273.10 respectively . CONCLUSIONS The OPV ( HDC ) vaccine was safe and immunogenicity for the children > or =2 months old .
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Intervention_Pharmacological
oral poliomyelitis attenuated live vaccine
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Intervention_Pharmacological
Poliomyelitis vaccine
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Intervention_Pharmacological
OPV ( HDC ) vaccine
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Intervention_Pharmacological
control vaccines
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Intervention_Pharmacological
OPV ( HDC ) vaccine
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Intervention_Pharmacological
OPV ( HDC ) vaccine
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Intervention_Pharmacological
OPV ( HDC ) vaccine
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Outcome_Other
safety
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Outcome_Physical
Immunogenicity
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Outcome_Physical
systemic reactions
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Outcome_Physical
immune success rates of I , II , III type
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Outcome_Physical
GMTs of I , II , III type
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Participant_Age
=2 month-old
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Participant_Sample-size
1200
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Participant_Age
children
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Participant_Age
2-5 months old
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Participant_Condition
OPV ( HDC ) vaccine