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document
Ipratropium bromide nasal spray for treatment of rhinorrhea in the laryngectomized patient : a pilot study . Many who have had a total laryngectomy complain of unrelenting rhinorrhea that is often very difficult to control . This study was undertaken to evaluate the effect of ipratropium bromide ( IB ) , an anticholinergic nasal spray , on rhinorrhea in these patients . This was designed as a prospective , randomized , double-blind , placebo-controlled , crossover pilot study . Participants were selected if they had a total laryngectomy and complained of rhinorrhea . They were asked to rate the severity and duration of their rhinorrhea each day throughout the study on a scale from zero to six . Each participant was initially given a saline nasal spray for one week . They were then randomized to use either IB or saline for the double-blinded portion of the study . Two sprays of IB at a dose of 42 micrograms/spray ( 0.06 % ) , or saline , were administered intranasally twice daily for two weeks , after which time the participants were given another nasal spray ( either IB or saline ) for the crossover portion of the study . Six patients entered and completed the study . Those patients using the IB recorded a mean 55 % decline in severity and a mean 51 % decline in duration of the rhinorrhea as compared to placebo . The relief in both severity and duration of rhinorrhea obtained by patients was analyzed using the Wilcoxon signed-rank test and found to be highly significant ( p < 0.001 ) . Despite the limitations of a small sample size in this study , ipratropium bromide nasal spray significantly reduced both the severity and duration of rhinorrhea in laryngectomized patients . We suggest ipratropium nasal spray as a safe , effective way to treat chronic rhinorrhea in laryngectomized patients , improving their quality of life .
6708
Intervention_Pharmacological
Ipratropium bromide nasal spray
6709
Intervention_Pharmacological
ipratropium bromide ( IB )
6710
Intervention_Control
placebo-controlled
6711
Intervention_Control
saline nasal spray
6712
Intervention_Pharmacological
IB
6713
Intervention_Control
saline
6714
Intervention_Pharmacological
IB
6715
Intervention_Control
saline
6716
Intervention_Pharmacological
IB
6717
Intervention_Control
saline
6718
Outcome_Physical
severity
6719
Outcome_Physical
duration of their rhinorrhea
6720
Outcome_Other
decline in severity
6721
Outcome_Physical
decline in duration of the rhinorrhea
6722
Outcome_Physical
severity and duration of rhinorrhea
6723
Outcome_Other
Wilcoxon signed-rank test
6724
Outcome_Physical
severity and duration of rhinorrhea
6725
Outcome_Other
quality of life
6726
Participant_Condition
rhinorrhea
6727
Participant_Condition
laryngectomized patient
6728
Participant_Condition
total laryngectomy
6729
Participant_Condition
rhinorrhea
6730
Participant_Sample-size
Six