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Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis . BACKGROUND Duration of untreated psychosis ( DUP ) has been significantly associated with poor clinical and social outcomes in First Episode Psychosis ( FEP ) patients , but an association with cognitive outcomes has not been clearly established . METHOD Seventy-seven consecutively admitted , drug-naïve patients with FEP were assessed at baseline and at 1month and 6months . Underlying dimensions of DUP ( general prodrome and positive , negative and disorganisation symptoms ) were assessed using the Symptom Onset in Schizophrenia ( SOS ) inventory ( Perkins et al. , 2000 ) . To assess the effect of DUP on the neuropsychological status of the patients , a linear mixed-effect model was fitted to each neuropsychological dimension . These models included a dichotomised version of DUP ( short versus long duration ) as a fixed effect , several adjusting variables to account for patient differences , and a random effect to incorporate the longitudinal structure of the data . RESULTS Patients with a short duration of untreated negative symptoms ( DUNS ) or a short duration of untreated positive symptoms ( DUPS ) outperformed patients with a long duration of untreated symptoms on memory tasks and a pre-attentional visual task but not on measures of verbal fluency , attention , reaction time , visual processing and executive functions . CONCLUSIONS This study provides additional support for an early intervention to shorten DUP to facilitate a better outcome in memory and attentional domains of FEP patients .
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Intervention_Educational
verbal fluency , attention , reaction time , visual processing and executive functions
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Outcome_Other
poor clinical and social outcomes
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Participant_Condition
psychosis
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Participant_Condition
first episode psychosis
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Participant_Sample-size
Seventy-seven