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document
Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery . Children are sensitive to the inflammatory side effects of cardiopulmonary bypass ( CPB ) . Our intention was to investigate if the biocompatibility benefits of heparin-coated CPB circuits apply to children . In 20 operations , 19 children were randomized to heparin-coated ( group HC , n = 10 ) or standard ( group C , n = 10 ) bypass circuits . Plasma levels of acute phase reactants , interleukins , granulocytic proteins and complement factors were measured . All were significantly elevated after CPB . Levels of complement factor C3a ( 851 ( 791-959 ) ng/ml [ median with quartiles ] in group C , 497 ( 476-573 ) ng/ml in group HC , p < 0.001 ) , Terminal Complement Complex ( 114 ( 71-130 ) AU/ml in group C , 35.5 ( 28.9-51.4 ) AU/ml in group HC , p < 0.001 ) , and interleukin-6 ( 570 ( 203-743 ) pg/ml in group C , 168 ( 111-206 ) pg/ml in group HC , p = 0.005 ) , were significantly reduced in group HC . Heparin-coated CPB circuits improve the biocompatibility of CPB during heart surgery in the paediatric patient population , as reflected by significantly reduced levels of circulating complement factors and interleukin-6 .
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Intervention_Physical
Heparin-coated cardiopulmonary bypass circuits
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Intervention_Physical
heparin-coated CPB circuits
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Intervention_Physical
heparin-coated
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Intervention_Control
standard
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Intervention_Physical
Heparin-coated CPB circuits
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Outcome_Physical
Plasma levels of acute phase reactants
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Outcome_Physical
interleukins
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Outcome_Physical
granulocytic proteins
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Outcome_Physical
complement factors
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Outcome_Physical
Levels of complement factor C3a
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Outcome_Physical
Terminal Complement Complex
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Outcome_Physical
interleukin-6