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document
Double-blind placebo-controlled administration of fluoxetine in restricting- and restricting-purging-type anorexia nervosa . BACKGROUND Anorexia nervosa is an often chronic disorder with high morbidity and mortality . Many people relapse after weight restoration . This study was designed to determine whether a selective serotonin reuptake inhibitor would improve outcome and reduce relapse after weight restoration by contributing to maintenance of a healthy normal weight and a reduction of symptoms . METHODS We administered a double-blind placebo-controlled trial of fluoxetine to 35 patients with restricting-type anorexia nervosa . Anorexics were randomly assigned to fluoxetine ( n = 16 ) or a placebo ( n = 19 ) after inpatient weight gain and then were observed as outpatients for 1 year . RESULTS Ten of 16 ( 63 % ) subjects remained on fluoxetine for a year , whereas only three of 19 ( 16 % ) remained on the placebo for a year ( p =.006 ) . Those subjects remaining on fluoxetine for a year had reduced relapse as determined by a significant increase in weight and reduction in symptoms . CONCLUSIONS This study offers preliminary evidence that fluoxetine may be useful in improving outcome and preventing relapse of patients with anorexia nervosa after weight restoration .
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
fluoxetine
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Intervention_Pharmacological
selective serotonin reuptake inhibitor
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
fluoxetine
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Intervention_Pharmacological
fluoxetine
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Intervention_Control
placebo
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Intervention_Pharmacological
fluoxetine
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Intervention_Control
placebo
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Intervention_Pharmacological
fluoxetine
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Intervention_Pharmacological
fluoxetine
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Outcome_Physical
weight restoration by contributing to maintenance of a healthy normal weight and a reduction of symptoms .
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Outcome_Mental
reduced relapse
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Outcome_Physical
significant increase in weight and reduction in symptoms .
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Outcome_Physical
relapse
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Participant_Condition
restricting- and restricting-purging-type anorexia nervosa .
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Participant_Condition
patients with anorexia nervosa