64032
document
Comparison of the cardiorespiratory effects of a combination of ketamine and propofol , propofol alone , or a combination of ketamine and diazepam before and after induction of anesthesia in dogs sedated with acepromazine and oxymorphone . OBJECTIVE To evaluate the cardiorespiratory effects of IV administration of propofol ( 4 mg/kg ) , ketamine hydrochloride and propofol ( 2 mg/kg each ; K-P ) , or ketamine hydrochloride ( 5 mg/kg ) and diazepam ( 0.2 mg/kg ; K-D ) before and after induction of anesthesia ( IoA ) in dogs sedated with acepromazine maleate and oxymorphone hydrochloride . ANIMALS 10 healthy adult Beagles . PROCEDURES Each dog was randomly allocated to receive 2 of 3 treatments ( 1-week interval ) . For instrumentation prior to each treatment , each dog was anesthetized with isoflurane . After full recovery , acepromazine ( 0.02 mg/kg ) and oxymorphone ( 0.05 mg/kg ) were administered IV . Fifteen minutes later ( before IoA ) , each dog received treatment IV with propofol , K-P , or K-D. Cardiorespiratory and arterial blood gas variables were assessed before , immediately after , and 5 minutes after IoA . RESULTS Compared with findings before IoA , dogs receiving the K-P or K-D treatment had increased cardiac output , oxygen delivery , and heart rate 5 minutes after IoA ; K-P administration did not change mean arterial blood pressure or stroke volume and decreased systemic vascular resistance . Propofol decreased mean arterial blood pressure and systemic vascular resistance immediately after IoA but did not change heart rate , cardiac output , or oxygen delivery . All treatments caused some degree of apnea , hypoventilation , and hypoxemia ( Pao2 < 80 mm Hg ) . CONCLUSIONS AND CLINICAL RELEVANCE In dogs , K-P treatment maintained mean arterial blood pressure better than propofol alone and increased heart rate , cardiac output , or oxygen delivery , as did the K-D treatment . Supplemental 100 % oxygen should be provided during IoA with all 3 treatments .
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Intervention_Pharmacological
ketamine
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Intervention_Pharmacological
propofol
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Intervention_Pharmacological
propofol
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Intervention_Pharmacological
ketamine
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Intervention_Pharmacological
diazepam
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Intervention_Pharmacological
induction of anesthesia in dogs sedated with acepromazine and oxymorphone
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Intervention_Pharmacological
propofol
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Intervention_Pharmacological
ketamine hydrochloride and propofol
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Intervention_Pharmacological
ketamine hydrochloride
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Intervention_Pharmacological
diazepam
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Intervention_Pharmacological
anesthesia
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Intervention_Pharmacological
acepromazine maleate
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Intervention_Pharmacological
oxymorphone hydrochloride
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Intervention_Pharmacological
anesthetized with isoflurane
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Intervention_Pharmacological
acepromazine
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Intervention_Pharmacological
oxymorphone
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Intervention_Pharmacological
propofol , K-P , or K-D.
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Intervention_Pharmacological
K-P
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Intervention_Pharmacological
K-D
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Intervention_Pharmacological
K-P
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Intervention_Pharmacological
K-P
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Intervention_Pharmacological
K-D
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Outcome_Physical
cardiorespiratory effects
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Outcome_Physical
Cardiorespiratory and arterial blood gas variables
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Outcome_Physical
cardiac output , oxygen delivery , and heart rate
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Outcome_Physical
mean arterial blood pressure or stroke volume and decreased systemic vascular resistance .
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Outcome_Physical
mean arterial blood pressure
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Outcome_Physical
systemic vascular resistance
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Outcome_Physical
heart rate
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Outcome_Physical
cardiac output
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Outcome_Physical
oxygen delivery
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Outcome_Physical
degree of apnea , hypoventilation , and hypoxemia
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Outcome_Physical
mean arterial blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
cardiac output
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Outcome_Physical
oxygen delivery
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Participant_Condition
10