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document
The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers . UNLABELLED Although effective in neuropathic pain , the efficacy of systemic lidocaine in non-neuropathic pain remains uncertain . We investigated the analgesic effect of systemic lidocaine on the heat/capsaicin sensitization model of experimental pain in 24 volunteers . Sensitization was produced by heating the skin to 45 degrees C for 5 min , followed by a 30-min application of 0.075 % capsaicin cream , and maintained by periodically reheating the sensitized skin . Subjects received IV lidocaine ( bolus 2 mg/kg , then infusion 3 mg. kg . h ) , or saline for 85 min . Areas of secondary hyperalgesia , heat pain detection thresholds , and painfulness of stimulation with 45 degrees C for 1 min ( long thermal stimulation ) were quantified . Systemic lidocaine reduced the area of secondary hyperalgesia to brush , but not to von Frey hair stimulation . Lidocaine did not alter heat pain detection thresholds or painfulness of long thermal stimulation in normal skin . We conclude that , at infusion rates in the low- to mid-antiarrhythmic range , lidocaine has no effect on acute nociceptive pain but does have a limited and selective effect on secondary hyperalgesia . IMPLICATIONS The efficacy of systemic lidocaine in nonneuropathic pain remains uncertain . This study investigates the effect of systemic lidocaine on experimental-induced hyperalgesia in 25 volunteers . Hyperalgesia was induced by using an experimental pain model that uses heat and capsaicin in combination . Systemic lidocaine showed a selective effect on secondary hyperalgesia .
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
systemic lidocaine
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Intervention_Physical
heating the skin
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Intervention_Pharmacological
capsaicin cream
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
saline
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
Lidocaine
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Intervention_Pharmacological
lidocaine
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Intervention_Pharmacological
lidocaine
4478
Intervention_Pharmacological
lidocaine
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Outcome_Pain
pain
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Outcome_Pain
secondary hyperalgesia
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Outcome_Physical
secondary hyperalgesia
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Outcome_Pain
heat pain detection thresholds
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Outcome_Pain
painfulness of long thermal stimulation
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Outcome_Pain
acute nociceptive pain
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Outcome_Physical
secondary hyperalgesia
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Outcome_Other
efficacy
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Outcome_Pain
nonneuropathic pain
4488
Outcome_Physical
experimental-induced hyperalgesia
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Outcome_Physical
Hyperalgesia
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Participant_Condition
pain and secondary hyperalgesia
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Participant_Condition
in healthy volunteers .
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Participant_Condition
non-neuropathic pain
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Participant_Condition
experimental pain in 24 volunteers .