77028
document
Intraocular pressure changes with propofol ( 'Diprivan ' ) : comparison with thiopentone . The effects of propofol , a new non-barbiturate intravenous anaesthetic agent , on intraocular pressure ( IOP ) were assessed and compared with those of thiopentone . IOP was measured using an applanation tonometer for 5 min following administration of induction doses of propofol or thiopentone and inhalation of 66 % nitrous oxide in oxygen . Both agents produced a significant fall in IOP for the period of study , by a maximum of 53 % with propofol and 40 % with thiopentone . Apnoea occurred with similar frequency in the two groups . Use of propofol was associated with a significant fall in arterial pressure and pain on injection in 5 out of 20 patients .
77029
Intervention_Pharmacological
propofol
77030
Intervention_Pharmacological
thiopentone
77031
Intervention_Pharmacological
propofol
77032
Intervention_Pharmacological
thiopentone
77033
Intervention_Pharmacological
propofol
77034
Intervention_Pharmacological
thiopentone
77035
Intervention_Pharmacological
nitrous oxide in oxygen
77036
Outcome_Physical
intraocular pressure
77037
Outcome_Physical
IOP
77038
Outcome_Physical
IOP
77039
Outcome_Adverse-effects
Apnoea
77040
Outcome_Physical
arterial pressure
77041
Outcome_Pain
pain on injection
77042
Participant_Sample-size
20 patients