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Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance . OBJECTIVE Coffee consumption has been associated with lower risk of type 2 diabetes . We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance . RESEARCH DESIGN AND METHODS We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee , 1 g chlorogenic acid , 500 mg trigonelline , and placebo ( 1 g mannitol ) on glucose and insulin concentrations during a 2-h oral glucose tolerance test ( OGTT ) in 15 overweight men . RESULTS Chlorogenic acid and trigonelline ingestion significantly reduced glucose ( -0.7 mmol/l , P = 0.007 , and -0.5 mmol/l , P = 0.024 , respectively ) and insulin ( -73 pmol/l , P = 0.038 , and -117 pmol/l , P = 0.007 ) concentrations 15 min following an OGTT compared with placebo . None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo . CONCLUSIONS Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT .
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Intervention_Pharmacological
decaffeinated coffee
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Intervention_Pharmacological
chlorogenic
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Intervention_Pharmacological
trigonelline
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Intervention_Pharmacological
Coffee
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Intervention_Pharmacological
decaffeinated coffee
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Intervention_Pharmacological
decaffeinated coffee
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Intervention_Pharmacological
chlorogenic acid
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Intervention_Pharmacological
trigonelline
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Intervention_Control
placebo
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Intervention_Pharmacological
mannitol
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Intervention_Control
placebo
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Outcome_Physical
glucose tolerance .
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Outcome_Physical
glucose
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Outcome_Physical
insulin
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Outcome_Physical
insulin or glucose area under the curve values
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Outcome_Physical
glucose and insulin responses
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Participant_Condition
glucose tolerance
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Participant_Condition
type 2 diabetes .
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Participant_Sample-size
15
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Participant_Condition
overweight
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Participant_Sex
men