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document
Oral amoxicillin vs. oral erythromycin in the treatment of pyoderma in Bamako , Mali : an open randomized trial . BACKGROUND Pyoderma ( bacterial superficial skin infection ) is an extremely common disorder in tropical developing countries . In these settings , Streptococcus pyogenes is considered to be the main etiological agent . Apart from epidemics of poststreptococcal glomerulonephritis where mass treatment with intramuscular benzathine-penicillin is recommended , no recommendation exists for the treatment of pyoderma in this setting . The aim of this study was to evaluate the efficacy of oral amoxicillin in the treatment of pyoderma in Mali , by comparison with oral erythromycin . METHODS In Bamako , 132 patients with pyoderma , diagnosed and graded as " severe " on clinical grounds , were randomly assigned to an oral treatment by either amoxicillin ( 50 mg/kg per day ) or erythromycin ; infections of the follicular appendage were excluded . Both drugs were associated with the topical application of povidone iodine . The patients were evaluated openly at the seventh day of treatment for cure or marked improvement of the clinical features , indicating successful treatment . RESULTS Three patients were lost to follow-up . Treatment was successful in 57 of 64 patients treated with amoxicillin vs. 58 of 65 patients treated with erythromycin ( P = 0.00 ) . CONCLUSIONS Amoxicillin was as efficacious as erythromycin in the treatment of severe pyoderma in Mali . Owing to its efficacy , added to high availability and low cost , this compound should be considered a first-line treatment of this disorder in this country , and perhaps in other countries where this condition presents in a similar way .
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Intervention_Pharmacological
amoxicillin
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Intervention_Pharmacological
erythromycin
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Intervention_Pharmacological
benzathine-penicillin
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Intervention_Pharmacological
amoxicillin
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Intervention_Pharmacological
erythromycin .
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Intervention_Pharmacological
amoxicillin
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Intervention_Pharmacological
erythromycin ;
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Outcome_Physical
treatment of pyoderma
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Outcome_Other
clinical features
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Outcome_Other
successful treatment
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Outcome_Other
Treatment was successful
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Outcome_Other
Amoxicillin was as efficacious
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Outcome_Physical
treatment of severe pyoderma
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Participant_Condition
treatment of pyoderma in Bamako , Mali :
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Participant_Condition
Pyoderma ( bacterial superficial skin infection )
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Participant_Condition
tropical developing countries .
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Participant_Condition
severe pyoderma in Mali .