79667
document
Platelet inhibitory drugs : an in vivo method of evaluation in patients . The measurement of platelet deposition in human thrombi is essential for the evaluation of platelet-inhibitory drugs and prosthetic materials for use in patients . The rate of 111Indium-labelled platelet accumulation on Dacron arterial grafts was measured in 27 patients randomised to take either aspirin and dipyridamole ( ASA + DPM ) or placebo . Autologous platelets were labelled and re-injected seven days following surgery and the graft thrombogenicity index calculated as the daily rise in the ratio of emissions from the graft over a reference site . The mean ( +/- SD ) thrombogenicity index in 12 patients undergoing femoro-popliteal bypass was 0.25 +/- 0.09 on placebo and 0.16 +/- 0.07 on ASA + DPM started pre-operatively ( p less than 0.05 ) . Post-operative ASA + DPM therapy started two days following platelet labelling in 15 patients with aorto-femoral grafts also significantly reduce thrombogenicity to 0.12 +/- 0.05 compared with 0.25 +/- 0.08 on placebo ( p less than 0.01 ) . In the latter patients the ratio of emissions from the graft over reference fell significantly on starting ASA + DPM , suggesting a net loss of platelets from the graft . These results indicate that the rate of in vivo platelet accumulation on Dacron grafts can be quantitated and that ASA + DPM reduced this rate in man .
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Intervention_Pharmacological
Platelet inhibitory drugs
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Intervention_Pharmacological
platelet-inhibitory drugs
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Intervention_Pharmacological
aspirin and dipyridamole ( ASA + DPM )
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Intervention_Control
placebo
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Intervention_Pharmacological
ASA
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Intervention_Pharmacological
DPM
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Intervention_Pharmacological
ASA + DPM
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Intervention_Pharmacological
ASA + DPM
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Outcome_Other
method of evaluation
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Outcome_Physical
platelet deposition
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Outcome_Physical
evaluation of platelet-inhibitory drugs
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Outcome_Physical
prosthetic materials
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Outcome_Physical
platelet accumulation
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Outcome_Physical
ratio of emissions
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Outcome_Physical
thrombogenicity index
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Outcome_Physical
thrombogenicity
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Outcome_Other
emissions
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Outcome_Physical
rate of in vivo platelet accumulation
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Participant_Condition
Platelet inhibitory drugs :
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Participant_Condition
platelet deposition in human thrombi
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Participant_Sample-size
27 patients