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Ethanol-induced alterations in electroencephalographic activity in adult males . The present investigation examined the effects of placebo ( P ) , low-dose ( LD ) , and high-dose ( HD ) ethanol on electroencephalographic ( EEG ) activity in 21 healthy , adult males ( X = 22.7 years ) . Only one condition ( P , LD , or HD ) was presented per day and the condition order was randomized . For each subject , blood-alcohol levels measured via breathalyzer and EEG activity , using the entire 10/20 International System , were recorded both prior to and at intervals of 35 , 70 , 105 , and 140 minutes after P , LD , or HD administration . The Fast Fourier Transform was used to calculate power spectral densities for each EEG recording . Measures of the relative areas under the power spectral curve were made for each of the following frequency bands : slow alpha ( 7.5 to 10 Hz ) ; fast alpha ( 10.5 to 13.0 Hz ) ; slow beta ( 13.5 to 19.5 Hz ) ; and fast beta ( 20 to 26 Hz ) at electrodes F3 , F4 , C3 , C4 , P3 , P4 , O1 , and O2 . Repeated-measures multivariate analysis of variance performed on normalized relative area values revealed that ethanol had significant effects on EEG activity at anterior sites : frontal ( F3 , F4 ) and central ( C3 , C4 ) that presented as increased activity in the slow alpha frequency band . These results suggest a differential responsivity of both cortical region and EEG frequency band to the effects of ethanol ingestion .
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Intervention_Control
placebo ( P )
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Intervention_Pharmacological
ethanol
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Outcome_Physical
electroencephalographic activity
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Outcome_Physical
electroencephalographic ( EEG
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Outcome_Other
)
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Outcome_Physical
EEG activity
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Outcome_Physical
EEG activity at anterior sites
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Outcome_Physical
cortical region and EEG frequency band
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Participant_Condition
adult males .
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Participant_Condition
( EEG ) activity in 21 healthy , adult males ( X = 22.7 years ) .