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document
Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese . BACKGROUND Current evidence suggests that a majority of the inherited risks play a major role in glioma susceptibility , and glioma is due to the co-inheritance of multiple low-risk variants . These variants can be identified through association studies including such as genome-wide association studies ( GWAS ) , which has led the glioma epidemiology researchers to focus on identifying potential disease-causing factors . METHODS We evaluated and validated 10 tag single nucleotide polymorphisms ( tSNPs ) in seven genes associated with glioma susceptibility in a Han Chinese population , including 301 glioma cases and 302 controls , using a multiplexed single nucleotide polymorphism ( SNP ) MassEXTEND assay . We ascertained the genotypic frequencies for each tSNP in control subjects were within Hardy-Weinberg equilibrium ( HWE ) using an exact test , and then compared the genotype and allele frequencies of glioma patients and control subjects using the χ2 test . We then applied three genetic models ( dominant , recessive , and additive ) using PLINK software to assess the association of each tSNP with glioma risk . RESULTS We identified two tSNPs to be associated with glioma susceptibility ( rs1695 , GSTP1 , P = 0.019 ; rs2853676 , TERT , P = 0.039 ) , which we confirmed using dominant and additive model analyses . The genotype & ldquo ; GA & rdquo ; for rs1695 was recognized to be a protective genotype for glioma ( OR , 0.67 ; 95 % CI , 0.47-0.96 ; P = 0.027 ) , while the genotype & ldquo ; AG & rdquo ; for rs2853676 was shown to be a risk genotype for glioma ( OR , 1.50 ; 95 % CI , 1.05-2.15 ; P = 0.025 ) . CONCLUSION Our results , and those from previous studies , suggest potential genetic contributes for GSTP1 and TERT in glioma development .
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Intervention_Other
multiplexed single nucleotide polymorphism ( SNP ) MassEXTEND assay
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Participant_Condition
glioma risk
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Participant_Condition
glioma
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Participant_Sample-size
301
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Participant_Sample-size
302