80122
document
Clinical evaluation of the antihypertensive effect of metoprolol in combination with hydrochlorothiazide and hydralazine in an unselected hypertensive population . One hundred nineteen patients with essential hypertension ( 96 completing six months and 92 a one year study period ) were randomized into four parallel groups and treated with one of four programs : 200 mg of metoprolol plus placebo ; 200 mg of metoprolol plus 25 mg of hydrochlorothiazide ; 200 mg of metoprolol plus 50 mg hydrochlorothiazide , or ; 200 mg metoprolol plus 50 mg of hydralazine . Blood pressure reduction was significant in these all groups and no differences were observed in blood pressure reduction among the groups . During the one year therapy the levels of serum bilirubin , uric acid and triglycerides were significantly increased in all groups but the group treated with metoprolol and hydralazine . Serum cholesterol level did not increase in any group during the one year therapy . The results indicate that the combination therapy in mild to moderate hypertension should not be initiated before individual response to single drug therapy is evaluated . Antihypertensive drug treatment may cause some biochemical changes and those changes seem to be smallest patients treated with combination of beta-blocker and hydralazine .
80123
Intervention_Pharmacological
metoprolol
80124
Intervention_Pharmacological
hydrochlorothiazide
80125
Intervention_Pharmacological
hydralazine
80126
Intervention_Pharmacological
200 mg of metoprolol plus placebo
80127
Intervention_Pharmacological
200 mg of metoprolol
80128
Intervention_Pharmacological
25 mg of hydrochlorothiazide
80129
Intervention_Pharmacological
200 mg of metoprolol
80130
Intervention_Pharmacological
50 mg hydrochlorothiazide
80131
Intervention_Pharmacological
200 mg metoprolol
80132
Intervention_Pharmacological
50 mg of hydralazine
80133
Intervention_Pharmacological
metoprolol
80134
Intervention_Pharmacological
hydralazine
80135
Intervention_Physical
beta-blocker
80136
Intervention_Pharmacological
hydralazine
80137
Outcome_Physical
Blood pressure reduction
80138
Outcome_Physical
levels of serum bilirubin
80139
Outcome_Physical
uric acid
80140
Outcome_Physical
triglycerides
80141
Outcome_Physical
Serum cholesterol level
80142
Outcome_Physical
mild to moderate hypertension
80143
Participant_Condition
hypertensive
80144
Participant_Sample-size
One hundred nineteen
80145
Participant_Condition
essential hypertension
80146
Participant_Sample-size
96
80147
Participant_Sample-size
92