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document
Lithium sustains the acute antidepressant effects of sleep deprivation : preliminary findings from a controlled study . Early morning sleep deprivation ( patient awake from 0200 to 2200 hours ) produces a same-day antidepressant effect in approximately one-half of patients with major depression . Unfortunately , these antidepressant effects are short-lived and patients usually relapse to baseline depression levels within 48 hours . Recent work suggests , however , that the use of lithium with early morning sleep deprivation sustains this rapid antidepressant effect and makes it clinically useful . In a 30-day study , we compared the abilities of four different treatments ( lithium plus early morning sleep deprivation , lithium plus a control sleep deprivation procedure , and desipramine with either of the two sleep manipulations ) to induce a rapid ( next-day ) and sustained antidepressant response in 16 depressed patients . Lithium plus early morning sleep deprivation produced a quicker response than lithium with the control sleep deprivation , and the response was sustained for at least 30 days . In this design , however , lithium/early morning sleep deprivation was no faster than either of the two desipramine/sleep deprivation conditions in inducing remission . These results support the results of previous studies and suggest further investigation of this novel sleep/pharmacologic intervention is warranted .
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Intervention_Pharmacological
Lithium
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Intervention_Pharmacological
lithium
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Intervention_Control
lithium plus early morning sleep deprivation
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Intervention_Control
lithium plus a control sleep deprivation procedure
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Intervention_Control
desipramine with either of the two sleep manipulations
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Intervention_Pharmacological
desipramine/sleep deprivation
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Intervention_Physical
sleep/pharmacologic intervention
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Outcome_Mental
antidepressant effects
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Outcome_Mental
antidepressant effect
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Outcome_Mental
effects
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Outcome_Mental
antidepressant effect
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Outcome_Mental
antidepressant response
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Outcome_Physical
inducing remission .
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Participant_Condition
acute antidepressant effects
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Participant_Condition
sleep deprivation :
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Participant_Condition
sleep deprivation
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Participant_Condition
major depression .
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Participant_Sample-size
16
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Participant_Condition
depressed