87871
document
Relation of total homocysteine and lipid levels in children to premature cardiovascular death in male relatives . We assessed the relative importance of lipid , apo B , lipoprotein ( a ) [ Lp ( a ) ] , and total homocysteine ( tHcy ) levels in children in relation to premature cardiovascular disease in family members . Parents of 381 girls and 375 boys age 8-12 y completed family history questionnaires . Nonfasting serum lipid and lipoproteins and plasma tHcy and cysteine levels were measured in the children . Serum folate and vitamin B12 levels were determined in a random subsample of 23 % of the children , who participated in a food frequency interview . Children whose parents reported hypercholesterolemia had higher total and non-HDL cholesterol and apo B levels than the rest , but these levels were not associated with cardiovascular disease . tHcy levels were similar in girls and boys . tHcy was higher in children whose father , grandfather , or uncle died at age < or = 55 y of myocardial infarction or sudden cardiac arrest ( n = 42 ) than in control children [ 5.92 mumol/L ( 95 % confidence interval [ CI ] of 5.47-6.36 ) versus 5.25 mumol/L ( 95 % CI , 5.16-5.34 ) ] , also after adjustment for socioeconomic group . Intake and serum levels of vitamin B12 and folate were within recommended or reference ranges . In a stepwise multiple regression analysis , serum folate ( negative correlation ) , plasma creatinine , and sugar intake as percent of dietary energy ( positive correlations ) were significantly associated with tHcy ( multiple r = 0.44 , adjusted r2 = 18 % ; 95 % CI , 5-30 % ) . Our data show that a modest elevation in tHcy in children was related to premature cardiovascular death in their male relatives and may partly account for the contribution of family history to risk of cardiovascular disease . tHcy may be modifiable through the diet , even in children with apparently adequate vitamin nutriture .
87872
Intervention_Pharmacological
homocysteine
87873
Intervention_Pharmacological
lipid levels
87874
Intervention_Pharmacological
lipid
87875
Intervention_Pharmacological
homocysteine
87876
Intervention_Educational
family history questionnaires
87877
Intervention_Pharmacological
serum lipid and lipoproteins and plasma tHcy and cysteine
87878
Intervention_Pharmacological
tHcy
87879
Intervention_Pharmacological
tHcy
87880
Intervention_Pharmacological
tHcy
87881
Outcome_Physical
lipid , apo B , lipoprotein ( a ) [ Lp ( a ) ] , and total homocysteine ( tHcy ) levels
87882
Outcome_Physical
Nonfasting serum lipid and lipoproteins and plasma tHcy and cysteine levels
87883
Outcome_Physical
Serum folate and vitamin B12 levels
87884
Outcome_Physical
total and non-HDL cholesterol and apo B levels
87885
Outcome_Physical
tHcy levels
87886
Outcome_Physical
tHcy
87887
Outcome_Physical
Intake and serum levels of vitamin B12 and folate
87888
Outcome_Physical
serum folate ( negative correlation ) , plasma creatinine , and sugar intake
87889
Outcome_Physical
tHcy
87890
Outcome_Physical
tHcy
87891
Outcome_Physical
premature cardiovascular death
87892
Outcome_Physical
tHcy
87893
Participant_Age
children
87894
Participant_Sex
male relatives
87895
Participant_Age
children
87896
Participant_Age
Parents
87897
Participant_Sample-size
381
87898
Participant_Sex
girls
87899
Participant_Sample-size
375
87900
Participant_Sex
boys
87901
Participant_Age
age 8-12 y