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document
A comparative study of methyldopa and labetalol in the treatment of hypertension . 1 Twenty patients with essential hypertension completed a double-blind , dose-tritrated , cross-over comparison of methyldopa and labetalol . 2 Average lying BPs ( systolic/diastolic ) were reduced by 28/15 mmHg with methyldopa and by 23/15 mmHg with labetalol . 3 Average standing BPs ( systolic/diastolic ) were reduced by 29/14 mmHg with methyldopa and by 29/15 mmHg with labetalol . 4 Both lying and standing heart rates were reduced with labetalol . 5 It is concluded that the antihypertensive properties of labetalol and methyldopa are similar but that larger patient populations are needed to study the relative incidence of subjective adverse effects .
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Intervention_Pharmacological
methyldopa
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Intervention_Pharmacological
labetalol
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Intervention_Pharmacological
methyldopa
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Intervention_Pharmacological
labetalol
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Intervention_Pharmacological
methyldopa
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Intervention_Pharmacological
labetalol
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Intervention_Pharmacological
methyldopa
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Intervention_Pharmacological
labetalol
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Intervention_Pharmacological
labetalol
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Intervention_Pharmacological
labetalol
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Intervention_Pharmacological
methyldopa
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Outcome_Physical
hypertension .
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Outcome_Physical
Average lying BPs ( systolic/diastolic )
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Outcome_Physical
Average standing BPs ( systolic/diastolic )
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Outcome_Physical
lying and standing heart rates
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Outcome_Physical
antihypertensive properties
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Participant_Condition
hypertension
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Participant_Sample-size
Twenty