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document
[ Effects of Kang Gang Qian Granule ( KGQG ) on clinical and pathological features in chronic hepatitis B patients ] . OBJECTIVE To explore the efficacy of KGQG and its therapeutic mechanisms in chronic hepatitis B patients with liver fibrosis . METHODS 57 chronic hepatitis B patients with liver fibrosis were randomly divided into two groups : 45 cases in KGQG group were treated by KGQG and routine medications ; 12 cases in control group were treated by routine medications only . Serum liver function test results , PCIII , CIV , HA and liver biopsy results of these 57 patients were simultaneously collected and analyzed before and after this intervention . RESULTS KGQG group showed better efficacy over control group in liver function recovery , decrease of serum PCIII , CIV , HA levels and liver pathologic grades ( P 0.05 or 0.01 ) . CONCLUSION The KGQG could effectively ameliorate liver function and facilitate the inhibition and degradation of liver fibrosis in chronic hepatitis B patients , which may be developed as a novel therapeusis to treat this hard-to-cure disease .
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Intervention_Pharmacological
Kang Gang Qian Granule ( KGQG )
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Intervention_Pharmacological
KGQG
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Intervention_Pharmacological
KGQG
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Intervention_Pharmacological
KGQG and routine medications
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Intervention_Pharmacological
KGQG
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Intervention_Pharmacological
KGQG
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Outcome_Physical
clinical and pathological features
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Outcome_Physical
Serum liver function test results , PCIII , CIV , HA and liver biopsy results
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Outcome_Other
efficacy
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Outcome_Physical
liver function recovery
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Outcome_Physical
serum PCIII , CIV , HA levels
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Outcome_Physical
liver pathologic grades
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Participant_Condition
chronic hepatitis B
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Participant_Condition
chronic hepatitis B
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Participant_Condition
liver fibrosis
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Participant_Sample-size
57
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Participant_Condition
chronic hepatitis B
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Participant_Condition
liver fibrosis
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Participant_Condition
liver fibrosis
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Participant_Condition
chronic hepatitis B