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document
Calcium acetate versus calcium carbonate as phosphate binders in hemodialysis patients . We conducted a randomized unblinded parallel clinical trial to compare the effectiveness , side effects and tolerance between calcium acetate ( CA ) and calcium carbonate ( CC ) in 80 stable chronic hemodialysis patients selected on the basis of their acceptable control of serum phosphorus ( P ) levels with aluminum hydroxide ( AH ) . All patients were dialyzed against the same calcium dialyzate ( 1.62 mmol/l ) . The serum analytical tests included : calcium corrected to total protein , P , PTH ( intact molecule ) and bicarbonate . The study was divided into the following periods : P0 : baseline measurements ; P1 : washout ( withdrawal of AH for 15 days ) ; P2 : random allocation to CA and CC treatment at doses equivalent to 75 mEq of elemental calcium , stratified according to previous doses of AH ( 2 months ) ; P3 : adjustment of doses until control P ( 2 months ) . CA was poorly tolerated in 7 patients and CC in 2 ( NS ) . The changes in serum P levels between P0 and P2 periods were lower in the CA group ( 1.73 +/- 0.25 vs. 1.80 +/- 0.50 mmol/l ; p = 0.26 ) than in the CC group ( 1.77 +/- 0.35 vs. 1.93 +/- 0.48 mmol/l ; p = 0.03 , paired t test ) . Serum calcium was hardly modified by CA ( 2.42 +/- 0.20 vs. 2.47 +/- 0.17 mmol/l ; NS ) while in the CC group , it rose significantly ( 2.40 +/- 0.12 vs. 2.55 +/- 0.22 mmol/l ; p = 0.0004 ) . There were no differences in the control of PTH or bicarbonate . ( ABSTRACT TRUNCATED AT 250 WORDS )
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Intervention_Pharmacological
Calcium acetate
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Intervention_Pharmacological
calcium carbonate
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Intervention_Pharmacological
calcium acetate ( CA )
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Intervention_Pharmacological
calcium carbonate ( CC )
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Intervention_Pharmacological
calcium dialyzate
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Intervention_Pharmacological
CA
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Intervention_Pharmacological
CC
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Outcome_Other
effectiveness
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Outcome_Adverse-effects
side effects
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Outcome_Physical
tolerance between calcium acetate ( CA ) and calcium carbonate ( CC )
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Outcome_Physical
calcium corrected to total protein , P , PTH ( intact molecule ) and bicarbonate
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Outcome_Other
CA was poorly tolerated
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Outcome_Physical
changes in serum P levels
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Outcome_Physical
Serum calcium
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Participant_Condition
hemodialysis patients
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Participant_Sample-size
80
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Participant_Condition
chronic hemodialysis