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document
[ Final evaluation of the randomized multicenter study SAKK 40/81 : adjuvant portal chemotherapy of curatively resected colorectal cancer ] . Between 1981 and 1987 , 533 patients from 9 institutions have been entered in a randomized trial to assess the value of adjuvant portal infusion ( 5-Fluorouracil , Mitomycin C ) compared to radical surgery alone . Analysis of 469 evaluable patients at a median follow-up of 5.8 years revealed 110 recurrences in the control and 94 recurrences in the infusion group . Estimated 5-year disease-free survival was 52 % and 61 % respectively ( hazard ratio 1:0.75 ; 95 % confidence interval 0.57-0.99 ; p = 0.046 ) . Overall survival was 59 % in the control and 69 in the infusion group ( p = 0.048 ) . Adjuvant portal infusion did not influence the occurrence of liver metastases but reduced the overall recurrence rate .
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Intervention_Physical
adjuvant portal chemotherapy
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Intervention_Surgical
adjuvant portal infusion ( 5-Fluorouracil , Mitomycin C ) compared to radical surgery alone
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Outcome_Mortality
5-year disease-free survival
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Outcome_Mortality
Overall survival
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Outcome_Physical
occurrence of liver metastases
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Outcome_Physical
overall recurrence rate .
22010
Participant_Condition
curatively resected colorectal cancer
22011
Participant_Sample-size
533
22012
Participant_Sample-size
469