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document
Evaluation of oral zinc sulfate effect on obsessive-compulsive disorder : a randomized placebo-controlled clinical trial . OBJECTIVE Obsessive-compulsive disorder is a common neuropsychiatric condition . Although various pharmaceutical agents are available for the treatment of obsessive-compulsive disorder , psychiatrists often find that many patients can not tolerate the side effects of these medications , the patients do not respond properly to the treatment , or the medications lose their effectiveness after a period of treatment . The augmentation with safe supplementation of medication , such as with trace elements , may be a solution to some of these problems . METHODS This study was a prospective , double-blinded , 8-wk trial . Twelve patients were given fluoxetine ( 20 mg/d ) plus zinc ( 440 mg/d ) and 11 patients were given fluoxetine plus placebo for 8 wk . RESULTS Both groups showed a decrease in the mean Yale-Brown Obsessive-Compulsive Scale score . Based on t tests , in weeks 2 and 8 , patients treated with fluoxetine plus zinc had significantly lower scores than those treated with fluoxetine plus placebo . CONCLUSION The results show that zinc , as adjuvant agent for obsessive-compulsive disorder , produces improved outcomes .
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Intervention_Pharmacological
oral zinc sulfate
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
fluoxetine
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Intervention_Pharmacological
plus zinc
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Intervention_Pharmacological
fluoxetine
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Intervention_Control
placebo
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Outcome_Mental
obsessive-compulsive disorder
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Outcome_Adverse-effects
side effects