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document
[ Preoperative chemotherapy of esophageal cancer ] . A series of 25 patients with advanced esophageal cancer treated from Mar . 1981 to Sep. 1982 by preoperative chemotherapy plus surgery is reported . All the patients came from the hospitals of the cooperative research group and were randomized into chemotherapy and control groups . They were proved by X-ray , cytology and histopathology prior to treatment . By histology , 22 cases were squamous cell carcinoma , 1 adenocarcinoma and 2 squamous adenocarcinoma . The COF chemotherapy consisted of Vincristine 1 mg , cyclophosphamide 600 mg and 5-fluorouracil 500 mg IV on days 1 and 8 with or without the addition of Pingyangmycin , a drug equivalent to Bleomycin A5 , at the dose of 10 mg IM on days 1 , 3 , 6 and 8 . The interval between the ending of chemotherapy and the surgical resection was 5-6 days . The results showed that preoperative chemotherapy caused no myelosuppression , but merely mild gastrointestinal symptoms . All patients were operated and resected without difficulty . The subjective improvement in various degrees and the shrinkage of tumor in the X-ray films were present in 5/25 cases who received preoperative chemotherapy . The histopathological changes in the chemotherapy and control groups ( 16 specimens ) were different . In the chemotherapy group , excessive keratinization in the squamous component of the esophageal cancerous tissue appeared in the resected specimens . The incidence of degeneration and necrosis in the squamous epithelium adjacent to carcinoma was higher in the chemotherapy group ( P less than 0.01 ) . The results suggested that such combined modality is worth further study .
62495
Intervention_Pharmacological
chemotherapy
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Intervention_Pharmacological
preoperative chemotherapy
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Intervention_Surgical
surgery
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Intervention_Pharmacological
chemotherapy
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Intervention_Control
control
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Intervention_Pharmacological
chemotherapy
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Intervention_Pharmacological
Vincristine
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Intervention_Pharmacological
cyclophosphamide
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Intervention_Pharmacological
5-fluorouracil
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Intervention_Pharmacological
Pingyangmycin
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Intervention_Pharmacological
Bleomycin A5
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Intervention_Pharmacological
chemotherapy
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Intervention_Surgical
surgical resection
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Intervention_Pharmacological
chemotherapy
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Intervention_Physical
chemotherapy
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Intervention_Pharmacological
chemotherapy
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Outcome_Physical
no myelosuppression
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Outcome_Physical
mild gastrointestinal symptoms .
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Outcome_Physical
shrinkage of tumor in the X-ray films
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Outcome_Physical
histopathological changes
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Outcome_Physical
excessive keratinization in the squamous component of the esophageal cancerous tissue
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Outcome_Physical
incidence of degeneration and necrosis in the squamous epithelium adjacent to carcinoma
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Participant_Condition
A series of 25 patients with advanced esophageal cancer treated from Mar .