84687
document
Cefprozil versus penicillin V in treatment of streptococcal tonsillopharyngitis . In a randomized multicenter study , the efficacy and safety of cefprozil were compared with those of penicillin in the treatment of group A streptococcal tonsillopharyngitis in children . Of the 409 patients enrolled , 323 were evaluable for their clinical and bacteriological responses ; of these 323 children , 172 received cefprozil and 151 received penicillin V. The clinical responses in patients treated with cefprozil were significantly better than those in patients who received penicillin ( 95.3 versus 88.1 % ; P = 0.023 ) . Eradication of the original serotype of group A streptococci was achieved in 91.3 % of patients treated with cefprozil and 87.4 % of patients treated with penicillin , the difference not being statistically significant ( P = 0.125 ) . However , there were significantly more symptomatic patients among the bacteriological failures in the penicillin group ( 68.4 % ) than in the cefprozil group ( 26.7 % ) . beta-Lactamase-producing Staphylococcus aureus was more frequently isolated from the throat flora during penicillin therapy than during cefprozil treatment . No difference in the incidence of adverse events probably related or of unknown relationship to the study drugs was observed in the two treatment groups ( 5.2 % of those treated with cefprozil and 6.0 % of those treated with penicillin ) . Cefprozil can be considered a safe and reliable drug for the treatment of streptococcal pharyngitis in children .
84688
Intervention_Pharmacological
Cefprozil
84689
Intervention_Pharmacological
penicillin V
84690
Intervention_Pharmacological
cefprozil
84691
Intervention_Pharmacological
penicillin
84692
Intervention_Pharmacological
cefprozil
84693
Intervention_Pharmacological
penicillin V.
84694
Intervention_Pharmacological
cefprozil
84695
Intervention_Pharmacological
penicillin
84696
Intervention_Pharmacological
cefprozil
84697
Intervention_Pharmacological
penicillin
84698
Intervention_Pharmacological
penicillin
84699
Intervention_Pharmacological
cefprozil
84700
Intervention_Pharmacological
penicillin therapy
84701
Intervention_Pharmacological
cefprozil
84702
Intervention_Pharmacological
cefprozil
84703
Intervention_Pharmacological
penicillin
84704
Intervention_Pharmacological
Cefprozil
84705
Outcome_Other
efficacy and safety
84706
Outcome_Physical
clinical responses
84707
Outcome_Physical
Eradication of the original serotype of group A streptococci
84708
Outcome_Physical
isolated from the throat flora
84709
Outcome_Adverse-effects
incidence of adverse events
84710
Participant_Condition
streptococcal tonsillopharyngitis
84711
Participant_Sample-size
409
84712
Participant_Sample-size
323
84713
Participant_Sample-size
323
84714
Participant_Condition
streptococcal pharyngitis