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document
Effect of betamethasone valerate on the normal human facial skin flora . Eighteen volunteers were randomly divided into two groups and allocated either an active corticosteroid preparation ( Betamethasone valerate ) or the basal formulation only ( placebo ) . The cream was applied to the face twice daily for one month . The treated area was sampled by the scrub-wash method immediately before treatment began and after 2 and 4 weeks , and microorganisms were enumerated and identified . Application of either cream produced a very slight increase ( less than or equal to 0.5 log cycle ) in the skin flora during the first 2 weeks of treatment . There were no significant differences in the changes occurring between volunteers treated with placebo and those on the steroid formulation . The results are discussed in relation to theories of pathogenesis of perioral dermatitis and steroid acne .
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Intervention_Pharmacological
betamethasone valerate
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Intervention_Pharmacological
active corticosteroid preparation ( Betamethasone valerate )
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Intervention_Control
basal formulation only ( placebo ) .
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Outcome_Physical
human facial skin flora .
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Outcome_Physical
skin flora
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Outcome_Physical
perioral dermatitis and steroid acne
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Participant_Condition
normal human facial skin flora
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Participant_Sample-size
Eighteen