41820
document
Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility : a prospective double-blind randomized crossover study . OBJECTIVES To evaluate the effect of sperm treatment with exogenous platelet-activating factor ( PAF ) on intrauterine insemination ( IUI ) clinical pregnancy rate in cases of mild male factor infertility . PAF is a phospholipid mediator , which is present in human sperm . METHODS The study was performed in the Assisted Reproduction Unit of the 2nd Department of Obstetrics and Gynecology , University of Athens , Aretaieion Hospital , Athens , Greece , and included 92 couples who presented with mild male factor infertility-all candidates for IUI . A maximum of 4 IUI cycles per couple with or without exogenous PAF treatment were performed and the main outcome measure was the clinical pregnancy rate ( pregnancies confirmed by ultrasonography per 100 cycles ) . RESULTS The overall clinical pregnancy rate after a maximum of 4 IUI cycles was comparable in cases with and without sperm treatment with PAF ( 12.24 % vs 11.11 % ) . Addition or exclusion of PAF sperm treatment in the same patients did not significantly alter the outcome . CONCLUSIONS The generalized use of exogenous PAF for the preparation of sperm in unselected cases of mild male infertility does not improve the clinical outcome of IUI .
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Intervention_Pharmacological
platelet-activating factor
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Intervention_Physical
intrauterine insemination
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Intervention_Pharmacological
exogenous platelet-activating factor ( PAF )
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Intervention_Physical
intrauterine insemination ( IUI )
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Intervention_Physical
IUI
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Intervention_Pharmacological
exogenous PAF treatment
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Intervention_Physical
IUI
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Intervention_Pharmacological
sperm treatment with PAF
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Intervention_Pharmacological
PAF sperm treatment
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Intervention_Pharmacological
exogenous PAF
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Outcome_Other
effect
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Outcome_Physical
clinical pregnancy rate
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Outcome_Physical
overall clinical pregnancy rate