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document
An exploratory study : the use of paroxetine for methamphetamine craving . Methamphetamine abuse and dependence are growing problems nationally and worldwide . There are currently no effective pharmocologic treatments . Animal studies with SSRI 's suggest that serotonergic modulation alters methamphetamine 's behavioral effects . This exploratory study is a trial of the effects of the SSRI paroxetine versus placebo ( in a double blind design ) on craving and use in a population of methamphetamine users . Many subjects dropped out of the study , but those in active treatment who completed the eight week trial had a decrease in methamphetamine craving compared to the placebo treatment as measured by the OCDS modified for use in this population . Statistical analyses were not performed due to the low number of subjects . The preliminary data suggest that serotonergic agents may play a role in the effective treatment of methamphetamine abuse and dependence within the context of other effective behavioral interventions .
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Intervention_Pharmacological
paroxetine
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Intervention_Pharmacological
Methamphetamine
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Intervention_Pharmacological
methamphetamine 's
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Intervention_Pharmacological
SSRI paroxetine
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Intervention_Control
placebo
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Intervention_Pharmacological
methamphetamine
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Intervention_Pharmacological
methamphetamine
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Intervention_Pharmacological
methamphetamine
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Outcome_Physical
methamphetamine craving
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Outcome_Mental
behavioral effects
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Outcome_Physical
methamphetamine craving
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Outcome_Physical
methamphetamine abuse and dependence
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Participant_Condition
methamphetamine craving