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document
Single and combined effects of atropine and metoclopramide on the lower oesophageal sphincter pressure . The effects of atropine and metoclopramide on the lower oesophageal sphincter pressure ( LOSP ) were studied in 12 healthy volunteers using oesophageal pressure transducers . Atropine decreased LOSP significantly at 5 min after i.v . injection ( P less than 0.005 ) and this change was sustained for 60 min . Metoclopramide increased LOSP significantly at 3 min after administration i.v . ( P less than 0.05 ) and this change was sustained for 40 min . Following consecutive administration of the drugs the effects of atropine predominated .
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Intervention_Pharmacological
atropine
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Intervention_Pharmacological
metoclopramide
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Intervention_Pharmacological
atropine
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Intervention_Pharmacological
metoclopramide
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Intervention_Pharmacological
Atropine
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Intervention_Pharmacological
Metoclopramide
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Intervention_Pharmacological
atropine
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Outcome_Physical
lower oesophageal sphincter pressure ( LOSP )
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Outcome_Physical
LOSP
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Outcome_Physical
LOSP
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Participant_Sample-size
12
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Participant_Condition
healthy volunteers using oesophageal pressure transducers .