13017
document
Preservative-free ocular hydrating agents in symptomatic contact lens wearers : saline versus PVP solution . PURPOSE To compare two preservative-free hydrating agents , in multidose ( ABAK ) bottles , in contact lens wearers experiencing symptoms of ocular dryness . METHODS The endpoint of this 4-week multicenter , randomized , double-blind , parallel-group study comparing a 2 % polyvinylpyrrolidone ( PVP ) solution with a 0.9 % NaCl solution was to assess ocular discomfort using a visual analog scale . A biomicroscopic examination and a test of tolerability on instillation were also performed , and adverse events were recorded . RESULTS Thirty-nine subjects were enrolled ( 23 PVP ; 16 NaCl ) . The average age was 30 ; subjects were predominantly female , and mostly wore frequent-replacement contact lenses . They were all exposed to environmental factors such as routine use of video monitors or air conditioning . The two groups were similar at baseline ( D0 ) . Both PVP and NaCl improved the comfort of contact lens wear ( P = 0.0003 ) , with no difference between them ( P = 0.25 ) . The mean daily duration of lens wear and the daily number of instillations to relieve discomfort ( 4.2 +/- 2.0 for PVP ABAK ; 4.6 +/- 1.9 for NaCl ABAK ) were comparable . However , PVP use led to more favorable evolution of fluorescein-staining corneal punctuations ( P = 0.028 ) . Safety was good , with minimal adverse events considered unrelated to the products . Lens wettability was excellent , and there were no clinically relevant deposits . Most subjects also found the ABAK bottles convenient . CONCLUSIONS Ocular hydration improves comfort in contact lens wearers . NaCl is an appropriate first-line treatment , but for subjects with fluorescein-staining punctuations , lubrication with PVP is preferable .
13018
Intervention_Pharmacological
Preservative-free ocular hydrating agents
13019
Intervention_Pharmacological
saline
13020
Intervention_Pharmacological
PVP solution
13021
Intervention_Pharmacological
preservative-free hydrating agents
13022
Intervention_Pharmacological
2 % polyvinylpyrrolidone ( PVP ) solution
13023
Intervention_Pharmacological
0.9 % NaCl solution
13024
Intervention_Pharmacological
PVP
13025
Intervention_Pharmacological
NaCl
13026
Intervention_Pharmacological
PVP
13027
Intervention_Pharmacological
NaCl
13028
Intervention_Pharmacological
PVP
13029
Intervention_Pharmacological
NaCl
13030
Intervention_Pharmacological
PVP
13031
Outcome_Physical
ocular dryness
13032
Outcome_Other
comfort of contact lens wear
13033
Outcome_Other
fluorescein-staining corneal punctuations
13034
Outcome_Other
Safety
13035
Outcome_Adverse-effects
adverse events
13036
Outcome_Other
Lens wettability
13037
Participant_Condition
symptomatic contact lens wearers
13038
Participant_Condition
contact lens wearers
13039
Participant_Condition
ocular dryness
13040
Participant_Sample-size
Thirty-nine
13041
Participant_Sample-size
23
13042
Participant_Sample-size
16
13043
Participant_Age
30
13044
Participant_Sex
female
13045
Participant_Condition
wore frequent-replacement contact lenses