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document
Lung function and respiratory symptoms in a 1-year randomized smoking cessation trial of varenicline in COPD patients . UNLABELLED There are few data concerning changes in lung function and respiratory symptoms in smokers with chronic obstructive pulmonary disease ( COPD ) weeks to months after quitting smoking . We examined serial changes in spirometry and Clinical COPD Questionnaire ( CCQ ) scores ( measuring respiratory symptoms and health-related quality of life ) in COPD participants by smoking status during a smoking cessation trial . In this randomized , double-blind trial , smokers with mild-to-moderate COPD were treated with varenicline 1 mg b.i.d . or placebo for 12 weeks and followed to Week 52 . Primary endpoints of abstinence were previously reported . Secondary endpoints were mean changes from baseline in post-bronchodilator forced expired volume in 1 s ( FEV ( 1 ) ) and CCQ scores . Change from baseline in post-bronchodilator FEV ( 1 ) was significantly improved in continuous abstainers ( 121.8 mL ) vs. continuous smokers ( 37.9 mL ) at Week 12 ( P = 0.0069 ) , but not at Weeks 24 or 52 . Mean change from baseline at Week 12 in CCQ Total Score was significantly better in continuous abstainers ( -1.04 ) vs. continuous smokers ( -0.53 ; P < 0.0001 ) : this improvement was sustained at Weeks 24 and 52 . In a 1-year cessation trial of smokers with COPD , continuous abstinence compared with continuous smoking significantly improved post-bronchodilator FEV ( 1 ) at Week 12 ( although the difference narrowed subsequently ) and CCQ Total Scores at Week 12 , with sustained improvement thereafter . ( TRIAL REGISTRY http : //www.clinicaltrials.gov ; trial identifier : NCT00285012 ) .
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Intervention_Pharmacological
varenicline
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Intervention_Pharmacological
varenicline 1 mg b.i.d .
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Intervention_Control
placebo
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Outcome_Mental
abstinence
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Outcome_Physical
post-bronchodilator forced expired volume in 1 s ( FEV ( 1 ) )
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Outcome_Physical
CCQ scores
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Outcome_Physical
FEV ( 1
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Outcome_Physical
CCQ Total Score
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Outcome_Mental
continuous abstinence
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Outcome_Physical
post-bronchodilator
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Outcome_Physical
CCQ Total Scores
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Participant_Condition
COPD patients
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Participant_Condition
chronic obstructive pulmonary disease ( COPD
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Participant_Condition
COPD
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Participant_Condition
COPD
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Participant_Condition
smokers with COPD