40201
document
Topical administration of diclofenac ( 1 % ) in the prevention of miosis during vitrectomy . PURPOSE A prospective , randomized clinical trial was conducted to assess the usefulness of preoperative diclofenac eye drops in maintaining mydriasis during vitrectomy and in reducing postoperative inflammation . METHODS Fifty consecutive patients undergoing vitrectomy were randomly assigned to diclofenac ( n = 24 ) or control ( n = 26 ) groups . All patients received a standard preoperative regimen of cyclopentolate ( 2 % ) and phenylephrine hydrochloride ( 2.5 % ) . The diclofenac group also received diclofenac ( 1 % ) preoperatively . Pupillary diameter was recorded at four time points during surgery . Inflammatory indices were measured postoperatively using slit-lamp examination . RESULTS After induction of anesthesia , the decrease in pupil size was not significantly different between the two groups ( P = 0.112 ) , but for the next two stages , it was significantly less in the diclofenac group ( P = 0.012 and P = 0.003 , respectively ) . No significant differences were found between the two groups for anterior chamber cells and redness in the eye postoperatively ( P = 0.609 and P = 0.123 , respectively ) . However , anterior chamber flare was significantly greater in the control group ( P = 0.035 ) , and patients felt significantly more pain in this group ( P = 0.001 ) . CONCLUSIONS Topical administration of diclofenac was effective in maintaining mydriasis during vitrectomy and in reducing postoperative pain and anterior chamber flare as determined by slit-lamp evaluations .
40202
Intervention_Pharmacological
diclofenac
40203
Intervention_Pharmacological
diclofenac
40204
Intervention_Pharmacological
diclofenac
40205
Intervention_Control
control
40206
Intervention_Pharmacological
cyclopentolate
40207
Intervention_Pharmacological
phenylephrine hydrochloride
40208
Intervention_Pharmacological
diclofenac
40209
Intervention_Pharmacological
diclofenac
40210
Intervention_Pharmacological
diclofenac
40211
Intervention_Pharmacological
diclofenac
40212
Outcome_Physical
miosis
40213
Outcome_Physical
postoperative inflammation .
40214
Outcome_Physical
Pupillary diameter
40215
Outcome_Physical
Inflammatory indices
40216
Outcome_Physical
decrease in pupil size
40217
Outcome_Physical
anterior chamber cells
40218
Outcome_Physical
redness in the eye
40219
Outcome_Physical
anterior chamber flare
40220
Outcome_Pain
pain
40221
Outcome_Physical
maintaining mydriasis
40222
Outcome_Pain
postoperative pain
40223
Outcome_Physical
anterior chamber flare