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Exercise for methamphetamine dependence : rationale , design , and methodology . BACKGROUND Effective pharmacotherapies to treat methamphetamine ( MA ) dependence have not been identified , and behavioral therapies are marginally effective . Based on behavioral studies demonstrating the potential efficacy of aerobic exercise for improving depressive symptoms , anxiety , cognitive deficits , and substance use outcomes , the study described here is examining exercise as a potential treatment for MA-dependent individuals . METHODS This study is randomizing 150 participants with MA dependence at a residential treatment facility for addictive disorders to receive either a thrice-weekly structured aerobic and resistance exercise intervention or a health education condition . Recruitment commenced in March , 2010 . Enrollment and follow-up phases are ongoing , and recruitment is exceeding targeted enrollment rates . CONCLUSIONS Seeking evidence for a possibly effective adjunct to traditional behavioral approaches for treatment of MA dependence , this study is assessing the ability of an 8-week aerobic and resistance exercise protocol to reduce relapse to MA use during a 12-week follow-up period after discharge from residential-based treatment . The study also is evaluating improvements in health and functional outcomes during and after the protocol . This paper describes the design and methods of the study .
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Intervention_Physical
Exercise
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Intervention_Pharmacological
methamphetamine
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Intervention_Physical
aerobic exercise
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Intervention_Physical
exercise
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Intervention_Physical
thrice-weekly structured aerobic and resistance exercise intervention or a health education condition
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Intervention_Physical
aerobic and resistance exercise
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Outcome_Mental
depressive symptoms , anxiety , cognitive deficits , and substance use outcomes
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Outcome_Mental
MA dependence
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Outcome_Mental
relapse to MA
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Outcome_Physical
health and functional outcomes
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Participant_Condition
methamphetamine dependence :
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Participant_Condition
MA-dependent individuals .