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document
Ciprofloxacin , lomefloxacin , or levofloxacin as treatment for chronic osteomyelitis . The efficacy and safety of three oral fluoroquinolones ( lomefloxacin , levofloxacin , and ciprofloxacin ) for the treatment of chronic osteomyelitis were analyzed . Twenty-seven patients had documented infections with quinolone-sensitive organisms and received either lomefloxacin , levofloxacin , or ciprofloxacin . Levofloxacin was effective therapy for 9 of 15 ( 60 % ) patients . Lomefloxacin was effective therapy for five of seven ( 71 % ) patients , and ciprofloxacin was effective therapy for two of five patients ( 40 % ) . Average follow-up was 11.8 months for patients who completed the course of therapy , and the average duration of therapy was 60.6 days . Gram-positive bacteria were isolated from 18 patients , and 11 patients were cured . Oral fluoroquinolones can be safe , effective therapy if they are given for a prolonged course as treatment for infections caused by susceptible gram-positive as well as gram-negative organisms and in combination with adequate surgical debridement .
2243
Intervention_Pharmacological
Ciprofloxacin
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Intervention_Pharmacological
lomefloxacin
2245
Intervention_Pharmacological
levofloxacin
2246
Intervention_Pharmacological
oral fluoroquinolones
2247
Intervention_Pharmacological
lomefloxacin
2248
Intervention_Pharmacological
levofloxacin
2249
Intervention_Pharmacological
ciprofloxacin
2250
Intervention_Pharmacological
lomefloxacin
2251
Intervention_Pharmacological
levofloxacin
2252
Intervention_Pharmacological
ciprofloxacin
2253
Outcome_Physical
chronic osteomyelitis .
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Outcome_Other
efficacy and safety
2255
Outcome_Other
duration of therapy
2256
Outcome_Physical
Gram-positive bacteria
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Outcome_Physical
cured
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Outcome_Other
safe , effective
2259
Participant_Condition
chronic osteomyelitis
2260
Participant_Sample-size
Twenty-seven
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Participant_Condition
infections with quinolone-sensitive organisms