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document
Satisfactory sampling in cytological cervical diagnosis : comparison between a conventional and a new sampling device . AIM Inadequate cervical sampling is the most frequent cause of misdiagnosis in cervical cancer screening . The aim of this study was to test the ability of PapCone® versus the conventional sampling method ( Ayre 's spatula plus cytobrush ) to collect ectocervical and glandular cells . MATERIALS AND METHODS In 18 healthy women , two ecto-endocervical samples , obtained by two different methods , were obtained at a three-month interval . Qualitative and quantitative parameters were evaluated . Ultrastructure features of sampling devices were analyzed by scanning electron microscopy ( SEM ) before and after sampling . RESULTS The χ ( 2 ) test revealed a statistically significant difference between the two methods : PapCone® caused less cell overlap and sampled less white blood cells ( p < 0.05 ) and more metaplastic cells ( p < 0.01 ) . SEM evaluation highlighted the porous and spongy structure of PapCone® that was responsible for the large number of glandular cells on its surface . CONCLUSION Cervical smears performed by PapCone® were adequate and generally easier to screen than conventionally performed ones .
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Intervention_Physical
sampling device
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Participant_Condition
cytological cervical diagnosis
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Participant_Condition
cervical cancer
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Participant_Sample-size
18
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Participant_Condition
healthy
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Participant_Sex
women