79218
document
Cognitive effects of lithium carbonate and haloperidol in treatment-resistant aggressive children . The effects of lithium carbonate and haloperidol on cognition were examined in a placebo-controlled , double-blind study of 61 treatment-resistant , hospitalized school-aged children . They all had a DSM-III diagnosis of conduct disorder -- undersocialized , aggressive , with a profile of highly explosive and aggressive behavior . Children were assessed at the end of a two-week placebo-baseline period and again after four weeks of treatment . Drug effects on cognition were mild . Haloperidol ( mean dose , 2.95 mg/day ) caused significant decreases in Porteus Maze test quotient scores and a slowing of reaction time ( RT ) on a simple RT task . Lithium carbonate ( mean dose , 1,166 mg/day ) adversely affected qualitative scores on the Porteus Maze test . No significant treatment effects were found for the Matching Familiar Figures Test , short-term recognition memory and concept attainment tasks , or the Stroop Test .
79219
Intervention_Pharmacological
lithium carbonate and haloperidol
79220
Intervention_Pharmacological
lithium carbonate and haloperidol
79221
Intervention_Control
placebo-controlled
79222
Intervention_Control
placebo-baseline
79223
Intervention_Pharmacological
Haloperidol
79224
Intervention_Pharmacological
Lithium carbonate
79225
Outcome_Mental
Porteus Maze test quotient scores
79226
Outcome_Mental
slowing of reaction time ( RT )
79227
Outcome_Mental
qualitative scores on the Porteus Maze test
79228
Outcome_Mental
Matching Familiar Figures Test
79229
Outcome_Mental
short-term recognition memory
79230
Outcome_Mental
concept attainment tasks
79231
Outcome_Mental
the Stroop Test
79232
Participant_Condition
treatment-resistant aggressive children .