63812
document
Effects of iron on the pharmacokinetics of paracetamol in saliva . Paracetamol has been reported to chelate with iron . It was found that no in vitro reaction between ferrous ion and paracetamol . Other studies found that there is an aerobic ( in the gastrointestinal tract ) oxidation of ferrous ion to ferric ion caused in iron-paracetamol in vivo reactions . The objective of this study was to determine if iron interacts with paracetamol and reduces paracetamol absorption . A randomized , double-blind , cross-over study design was used to assess the in vivo interaction of paracetamol and ferrous ion . Paracetamol ( 1.0 g ) was co-ignested alone or with ( 300 mg ) ferrous sulphate by ten healthy male volunteers , using saliva drug levels as a parameter . Concomitant administration of ferrous sulphate and paracetamol , decreased AUC8 from 42.88 +/- 3.8-34.25 +/- 2.8 microg h mL ( -1 ) ( p = 0.04 ) and Cmax from 18.75 +/- 1.9 to 15.9 +/- 1.7 microg mL ( -1 ) ( p = 0.11 ) , while no change in tmax ( p = 0.5 ) was originated . A significant difference was found in the paracetamol pharmacokinetic parameter oral clearance ( C1/F ) ( p = 0.02 ) and slightly increased in volume of distribution ( V ( d ) /F ) ( p = 0.10 ) . Co-administration of iron and paracetamol results in decreased paracetamol absorption due to an interaction between iron and paracetamol .
63813
Intervention_Pharmacological
iron
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Intervention_Pharmacological
paracetamol
63815
Intervention_Pharmacological
Paracetamol
63816
Intervention_Pharmacological
iron
63817
Intervention_Pharmacological
paracetamol
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Intervention_Pharmacological
ferrous ion
63819
Intervention_Pharmacological
Paracetamol
63820
Intervention_Pharmacological
ferrous sulphate
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Intervention_Pharmacological
ferrous sulphate
63822
Intervention_Pharmacological
paracetamol
63823
Intervention_Pharmacological
iron
63824
Intervention_Pharmacological
paracetamol
63825
Outcome_Physical
pharmacokinetics of paracetamol in saliva
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Outcome_Physical
paracetamol absorption
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Outcome_Other
in vivo interaction of paracetamol and ferrous ion
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Outcome_Physical
AUC8
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Outcome_Physical
Cmax
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Outcome_Other
paracetamol pharmacokinetic parameter oral clearance ( C1/F )
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Outcome_Physical
volume of distribution
63832
Outcome_Physical
paracetamol absorption
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Participant_Sample-size
ten
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Participant_Condition
healthy
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Participant_Sex
male