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document
[ Protective effect of ischemia postconditioning on reperfusion injury in patients with ST-segment elevation acute myocardial infarction ] . OBJECTIVE To observe the effect of ischemia postconditioning during the first minutes of reperfusion for the myocardial reperfusion injury in ST-segment elevation acute myocardial infarction ( STEMI ) patients undergoing emergency percutaneous coronary intervention ( PCI ) . METHODS STEMI patients undergoing emergency PCI in affiliated hospital of Beihua University between October 2006 and January 2009 were randomly divided into two groups : the control group ( n = 34 ) without any intervention after PTCA , and the postconditioning group ( n = 30 ) with ischemia postconditioning within first minutes of reflow by 3 episodes of 30-second inflation and 30-second deflation with the angioplasty balloon . Reperfusion arrhythmias , CK and CKMB , corrected TIMI frame count ( CTFC ) , wall motion score index ( WMSI ) and left ventricular ejection fraction ( LVEF ) by echocardiography were compared between the two groups . MI areas were evaluated with the ECG-54 criteria/32 system and myocardial blush grade ( MBG ) was measured . RESULTS The incidence of reperfusion arrhythmias-frequent ventricular premature ( 26.7 % vs. 52.9 % ) and short array ventricular tachycardia beat ( 23.3 % vs. 58.8 % ) as well as values of peaks CK [ ( 1162 ± 548 ) U/L vs. ( 1732 ± 480 ) U/L , P < 0.01 ] , CKMB [ ( 165 ± 70 ) U/L vs. ( 280 ± 99 ) U/L , P < 0.01 ] , CTFC ( 22.23 ± 3.81 vs. 26.97 ± 3.42 ) , WMSI ( 1.27 ± 0.52 vs. 1.82 ± 0.83 ) , and infarction areas determined by ECG methods ( 10.60 % ± 4.97 % vs.14.65 % ± 6.88 % , all P < 0.05 ) were all significantly lower in the postconditioning group than in control group while LVEF ( 0.55 ± 0.08 vs. 0.47 ± 0.10 ) and MBG ( 2.27 ± 0.64 vs. 1.47 ± 0.61 , all P < 0.05 ) were significantly higher in the postconditioning group than in control group . CONCLUSIONS Ischemia postconditioning can significantly reduce myocardial reperfusion injury in patients with STEMI .
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Intervention_Physical
ischemia postconditioning
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Intervention_Physical
ischemia postconditioning
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Intervention_Surgical
emergency percutaneous coronary intervention ( PCI ) .
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Intervention_Surgical
emergency PCI
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Intervention_Control
without any intervention after PTCA
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Intervention_Surgical
postconditioning group
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Intervention_Physical
with ischemia postconditioning
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Intervention_Surgical
angioplasty balloon
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Outcome_Physical
Reperfusion arrhythmias
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Outcome_Other
CK and CKMB
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Outcome_Other
corrected TIMI frame count ( CTFC )
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Outcome_Other
wall motion score index ( WMSI )
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Outcome_Other
left ventricular ejection fraction ( LVEF )
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Outcome_Other
myocardial blush grade ( MBG )
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Outcome_Adverse-effects
incidence of reperfusion arrhythmias-frequent ventricular premature
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Outcome_Physical
short array ventricular tachycardia beat
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Outcome_Physical
peaks CK
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Participant_Condition
ST-segment elevation acute myocardial infarction
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Participant_Condition
ST-segment elevation acute myocardial infarction ( STEMI )
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Participant_Condition
emergency percutaneous coronary intervention ( PCI )
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Participant_Condition
STEMI
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Participant_Condition
emergency PCI
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Participant_Sample-size
34
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Participant_Sample-size
30