15607
document
Bupropion SR and counseling for smoking cessation in actual practice : predictors of outcome . To date , only one study has been published on individual characteristics associated with outcome following standard treatment with bupropion SR for smoking cessation . To investigate treatment outcome beyond the 6-week end-of-treatment point , the present study examined characteristics associated with more clinically relevant smoking endpoints following treatment with bupropion SR in a large health care system . A total of 1,524 smokers ( 649 men and 875 women ) of average age 45.1 years were randomized to receive one of four combinations of bupropion SR ( 150 or 300 mg ) and behavioral counseling ( tailored mailings or proactive telephone counseling ) and assessed for point-prevalent smoking status at 3 and 12 months . Multiple logistic regression analyses of potential risk factors for 12-month point-prevalent smoking and for persistent smoking ( point-prevalent smoking at both follow-ups ) following treatment were conducted for men and women combined and separately . Risk factors for smoking at both endpoints in the combined sample included treatment with tailored mailings , female gender , younger age , higher levels of tobacco dependence , shorter previous quit attempts , previous use of nicotine replacement therapy , and report of current depressive symptoms or lifetime depression . Risk factors for smoking following treatment identified in women only included treatment with the lower dose of bupropion SR , younger age , and higher perceived stress , whereas those that were unique to men included the presence of lifetime depression . The results are discussed in terms of their implications for the need for more effective treatments in general , and the role of individual differences in the likelihood of returning to smoking following treatment for quitting .
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Intervention_Pharmacological
Bupropion SR
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Intervention_Educational
counseling for smoking
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Intervention_Pharmacological
standard treatment with bupropion SR
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Intervention_Pharmacological
bupropion SR
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Intervention_Pharmacological
bupropion SR
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Intervention_Educational
behavioral counseling ( tailored mailings or proactive telephone counseling )
15614
Intervention_Pharmacological
bupropion SR
15615
Outcome_Other
need for more effective treatments
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Outcome_Mental
likelihood of returning to smoking following treatment for
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Participant_Condition
smoking cessation
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Participant_Sample-size
1,524 smokers
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Participant_Sex
649 men
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Participant_Sex
875 women
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Participant_Age
average age 45.1 years