52992
document
MSLT in primary insomnia : stability and relation to nocturnal sleep . STUDY OBJECTIVES To assess the stability of the multiple sleep latency test ( MSLT ) in primary insomnia and its relation to total sleep time . DESIGN Randomized , double-blind , placebo controlled , clinical trial . SETTING Outpatient with sleep laboratory assessments in months 1 and 8 of treatment . PARTICIPANTS Ninety-five primary insomniacs , 32-64 years old and 55 age- and sex-matched general population-based , representative controls . INTERVENTIONS After a screening nocturnal polysomnograms ( NPSG ) and MSLT the following day , participants with primary insomnia were randomized to take zolpidem 10 mg ( n = 50 ) or placebo ( n = 45 ) nightly for 12 months . During months 1 and 8 , while taking their prescribed treatments , NPSGs and MSLTs the following day were conducted . A population-based sample served as controls and received a single NPSG followed by MSLT . RESULTS Mean daily sleep latency on the screening MSLT of insomniacs was normally distributed across the full range of MSLT scores and significantly higher than those of a population-based representative control sample ( P < 0.006 ) . The insomniacs with the highest screening MSLTs had the shortest screening total sleep times ( P < 0.05 ) . The MSLTs of insomniacs during treatment in study month 1 were correlated ( r = 0.44 , P < 0.001 ) with their month 8 MSLT . The mean MSLT score of the zolpidem group did not differ from that of the placebo group , and the stability within treatment groups also did not differ . CONCLUSIONS These data support the hypothesis that some insomniacs show a reliable disorder of hyperarousal with increased wake drive both at night and during the day .
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Intervention_Physical
MSLT
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Intervention_Physical
multiple sleep latency test ( MSLT )
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Intervention_Physical
nocturnal polysomnograms ( NPSG )
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Intervention_Physical
MSLT
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Intervention_Pharmacological
zolpidem
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Intervention_Control
placebo
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Intervention_Physical
MSLTs
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Intervention_Physical
MSLT
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Intervention_Physical
MSLT
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Intervention_Physical
MSLT
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Intervention_Physical
MSLTs
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Intervention_Physical
MSLTs
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Intervention_Physical
MSLT
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Outcome_Mental
insomnia :
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Outcome_Physical
nocturnal sleep
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Outcome_Mental
.
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Outcome_Physical
primary insomnia
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Outcome_Physical
total sleep time
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Outcome_Mental
.
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Outcome_Physical
Mean daily sleep latency on the screening MSLT of insomniacs
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Outcome_Physical
screening total sleep times
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Outcome_Physical
mean MSLT score
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Outcome_Physical
hyperarousal
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Outcome_Physical
wake drive
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Participant_Sample-size
Ninety-five
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Participant_Condition
insomniacs
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Participant_Age
32-64 years old and 55 age-
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Participant_Condition
primary insomnia