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document
Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma . Colorectal carcinoma is one of the most common malignancies in the world , and its incidence has increased in recent years . We have reported that expression of hypoxia-inducible factor ( HIF ) -1alpha correlates with expression of vascular endothelial growth factor ( VEGF ) , tumor stage , lymphatic invasion , venous invasion , and liver metastasis . It has also been reported that a single nucleotide polymorphism ( SNP ) in exon 12 of HIF-1alpha gene is present in renal cell carcinoma and head and neck squamous cell carcinoma patients . We investigated the C1772T polymorphism in colorectal cancer patients and healthy control subjects to clarify the mechanism of HIF-1alpha activation in colorectal carcinoma . The exon 12 genotype was not associated with sex or age . The distribution of HIF-1alpha genotypes in controls was 89 C/C ( 89 % ) , 11 C/T ( 11 % ) , and 0 T/T ( 0 % ) . The distribution of HIF-1alpha genotypes in colorectal cancer patients was 100 C/C ( 100 % ) , 0 C/T ( 0 % ) , and 0 T/T ( 0 % ) . The difference in genotype distribution between patients and control subjects was significant ( p < 0.0005 ) . These results suggest that the C1772T polymorphism in HIF-1alpha is not involved in progression or metastasis of colorectal carcinoma .
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Intervention_Pharmacological
Single nucleotide polymorphism
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Intervention_Pharmacological
single nucleotide polymorphism ( SNP )
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Intervention_Pharmacological
C1772T polymorphism
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Intervention_Other
HIF-1alpha activation
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Intervention_Control
control
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Intervention_Pharmacological
C1772T
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Outcome_Physical
HIF-1alpha genotypes
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Outcome_Physical
HIF-1alpha genotypes
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Outcome_Physical
C1772T polymorphism
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Participant_Condition
Colorectal carcinoma
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Participant_Condition
colorectal cancer patients
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Participant_Condition
healthy control subjects
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Participant_Condition
colorectal cancer