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document
Dental prophylaxis decreases the risk of esophageal cancer in males ; a nationwide population-based study in Taiwan . BACKGROUND Periodontal disease ( PD ) is one of the most common chronic inflammatory diseases . Esophageal cancer ( EC ) is also a common cause of death due to cancer among males . Systemic inflammatory processes have been shown to increase the risk of cancer . We conducted a retrospective cohort study to investigate the association between PD and EC . METHODS A total of 718,409 subjects were recruited from the Taiwan National Health Insurance Research Database ( NHIRD ) and followed from January 1 , 2000 to December 31 , 2010 . Of these , 519,831 subjects were diagnosed with PD and were grouped according to the most advanced treatment they received : dental prophylaxis , intensive treatment , or no treatment . The IRs of EC were compared among groups . RESULTS A total of 682 patients developed EC , resulting in an overall IR of 0.11 case-number per 1000 person-years ( ‰/y ) . The dental prophylaxis group had a significantly lower IR of EC ( 0.06‰/y ) than other groups ( p < 0.001 ) . Multivariable Cox regression analysis further revealed that male subjects [ hazard ratio ( HR ) = 10.04 , 95 % confidence interval ( CI ) = 7.58-13.30 ] , as well as a history of esophageal ulcers ( HR = 7.10 , 95 % CI = 5.03-10.01 ) , alcohol abuse ( HR = 5.46 , 95 % CI = 2.26-13.18 ) , or esophageal reflux ( HR = 1.86 , 95 % CI = 1.02-3.52 ) , were factors associated with a higher risk of EC . And the dental prophylaxis group showed a significantly lower risk for EC ( HR = 0.53 , 95 % CI = 0.44-0.65 ) . Further subgroup analysis showed that the dental prophylaxis group among males had a significant lower risk ( HR = 0.54 , 95 % CI = 0.44-0.66 ) for EC , while that of the females did not has statistically significant difference . CONCLUSION For this cohort , subjects received dental prophylaxis reduced the risk of EC compared to all PD and no PD groups among males .
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Intervention_Surgical
Dental prophylaxis
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Intervention_Surgical
dental prophylaxis
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Intervention_Control
no treatment
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Outcome_Physical
esophageal cancer
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Outcome_Physical
Esophageal cancer ( EC )
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Outcome_Physical
cancer .
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Outcome_Physical
PD
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Outcome_Physical
EC
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Outcome_Physical
IRs of EC
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Outcome_Physical
EC
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Outcome_Physical
overall IR
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Participant_Condition
Dental prophylaxis decreases
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Participant_Condition
esophageal cancer
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Participant_Sex
males
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Participant_Condition
Esophageal cancer ( EC )
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Participant_Condition
cancer
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Participant_Sex
males
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Participant_Sample-size
718,409
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Participant_Condition
National Health Insurance Research Database ( NHIRD
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Participant_Sample-size
519,831
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Participant_Sample-size
682
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Participant_Sex
male