76846
document
Parietal cell density in duodenal ulcer patients after short-term treatment with cimetidine and antacids . In a prospective study , 20 patients with endoscopically proven duodenal ulcers were randomised to be treated with cimetidine 1 g daily or with antacids 350 mmol daily . The duration of treatment was 30 days , but this was extended to three months in 3 patients in the cimetidine group and 4 patients in the antacid group . A morphological study of biopsies taken via a gastroscope from the corpus mucosa showed no change in mucosal height , parietal cell density per unit volume or changes in cellular infiltration after 30 and 90 days treatment in the two groups . Neither H-2 receptor blockers nor antacids alter mucosal height or parietal cell density . Treatment was not found to induce gastritic changes in the mucosa .
76847
Intervention_Pharmacological
cimetidine
76848
Intervention_Pharmacological
antacids
76849
Intervention_Pharmacological
cimetidine
76850
Intervention_Pharmacological
antacids
76851
Intervention_Pharmacological
cimetidine
76852
Intervention_Pharmacological
antacid
76853
Intervention_Pharmacological
H-2 receptor blockers
76854
Intervention_Pharmacological
antacids
76855
Outcome_Physical
Parietal cell density
76856
Outcome_Physical
mucosal height
76857
Outcome_Physical
parietal cell density per unit volume
76858
Outcome_Physical
changes in cellular infiltration
76859
Outcome_Physical
mucosal height
76860
Outcome_Physical
parietal cell density
76861
Outcome_Physical
gastritic changes
76862
Participant_Condition
duodenal ulcer
76863
Participant_Condition
endoscopically proven duodenal ulcers