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document
Successful treatment of depressed , distensible acne scars using autologous fibroblasts : a multi-site , prospective , double blind , placebo-controlled clinical trial . BACKGROUND A previous clinical trial evaluating autologous fibroblasts ( human dermal ) injections for the treatment of facial contour deformities found significantly greater improvements in wrinkle and acne scar appearance than with placebo treatment . OBJECTIVE To compare the efficacy and safety of autologous fibroblast treatment of moderate to severe , depressed , distensible facial acne scars with that of vehicle control . METHODS This was a randomized multicenter , double-blind , placebo-controlled trial in subjects with bilateral moderate to severe acne scarring ; subjects served as their own controls . Skin biopsies were obtained from randomized subjects for fibroblast production . Subjects ( n = 99 ) underwent three intradermal injection sessions with 2 mL of autologous fibroblast suspension ( 10-20 million cells/mL ) on one cheek and vehicle control ( cell culture medium ) on the other at 14-day intervals . Efficacy was based on the blinded subject 's , evaluator 's , and independent photographic viewer 's ( IPR ) assessment of acne scarring 1 to 4 months after the last treatment . RESULTS Autologous fibroblast treatment was associated with significantly greater treatment success than vehicle control for the subject ( 43 % vs.18 % ) , evaluator ( 59 % vs. 2 % ) , and IPR assessments . Autologous fibroblast injections were well tolerated , without permanent adverse effects . CONCLUSIONS Autologous fibroblast injections safely and effectively improved the appearance of depressed distensible acne scars .
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Intervention_Pharmacological
autologous fibroblasts
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Intervention_Pharmacological
autologous fibroblasts ( human dermal ) injections
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Intervention_Control
placebo
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Intervention_Pharmacological
autologous fibroblast
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
2 mL of autologous fibroblast suspension
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Intervention_Control
vehicle control
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Intervention_Pharmacological
Autologous fibroblast treatment
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Intervention_Pharmacological
Autologous fibroblast injections
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Intervention_Pharmacological
Autologous fibroblast injections
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Outcome_Physical
wrinkle and acne scar appearance
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Outcome_Physical
acne scarring
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Outcome_Physical
appearance of depressed distensible acne scars