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document
A comparative analysis of the effects of the fixed combination of timolol and dorzolamide versus latanoprost plus timolol on ocular hemodynamics and visual function in patients with primary open-angle glaucoma . AIMS The aim of this study was to assess the effects of fixed combination of timolol and dorzolamide and latanoprost plus timolol on retinal , choroidal , and retrobulbar hemodynamics and visual function in primary open-angle glaucoma ( OAG ) subjects . METHODS Sixteen ( 16 ) OAG patients ( age , 63.5 +/- 10.8 years ; 9 male ) were evaluated in a randomized , crossover , double-blind study design after 4 weeks of treatment of latanoprost with timolol and fixed combination of timolol and dorzolamide . After randomization , 9 right eyes and 7 left eyes were included in the hemodynamic portion of the study . Measurements included : adverse events check , visual acuity , contrast sensitivity , blood pressure , heart rate , intraocular pressure ( IOP ) , and fundus examination . Ocular blood flow was assessed using confocal scanning laser Doppler flowmetry , color Doppler imaging , and scanning laser ophthalmoscopy . RESULTS Both therapies were effective at lowering IOP , whereas there was no statistically significant difference between latanoprost plus timolol and the fixed combination of timolol and dorzolamide ( 13.9 % and 12.2 % reduction , respectively ; P = 0.5533 ) . Fixed combination of timolol and dorzolamide significantly increased central retinal artery end diastolic blood flow velocity ( P = 0.0168 ) and lowered resistance to flow ( P = 0.0279 ) . Temporal posterior ciliary artery peak systolic and end diastolic velocities were significantly increased with the fixed combination of timolol and dorzolamide ( P = 0.0125 and 0.0238 , respectively ) . Latanoprost plus timolol had no significant effects on ocular blood flow during 4 weeks of treatment . There were no statistically significant differences in adverse events , blood pressure , heart rate , visual acuity , contrast sensitivity scanning laser ophthalmoscopy , or Heidelberg Retinal Flowmeter for any treatment period . CONCLUSIONS Fixed combination of timolol and dorzolamide therapy might increase blood flow in OAG patients while attaining a similar IOP reduction compared to latanoprost plus timolol . Visual function , however , was not different in this short-term comparison between the two treatments .
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Intervention_Pharmacological
combination of timolol and dorzolamide
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Intervention_Pharmacological
timolol and dorzolamide and latanoprost plus timolol
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Intervention_Pharmacological
latanoprost with timolol
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Intervention_Pharmacological
timolol and dorzolamide .
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Intervention_Pharmacological
combination of timolol and dorzolamide
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Intervention_Pharmacological
Latanoprost plus timolol
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Outcome_Physical
ocular hemodynamics
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Outcome_Physical
visual function
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Outcome_Physical
retinal , choroidal , and retrobulbar hemodynamics
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Outcome_Adverse-effects
adverse events check
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Outcome_Physical
visual acuity
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Outcome_Physical
contrast sensitivity
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
intraocular pressure ( IOP )
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Outcome_Physical
fundus examination
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Outcome_Physical
Ocular blood flow
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Outcome_Physical
IOP
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Outcome_Physical
central retinal artery end diastolic blood flow velocity
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Outcome_Physical
resistance to flow
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Outcome_Physical
Temporal posterior ciliary artery peak systolic and end diastolic velocities
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Outcome_Physical
ocular blood flow
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Outcome_Adverse-effects
adverse events
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Outcome_Physical
blood pressure
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Outcome_Physical
heart rate
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Outcome_Physical
visual acuity
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Outcome_Other
contrast sensitivity scanning laser ophthalmoscopy
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Outcome_Physical
Heidelberg Retinal Flowmeter
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Outcome_Physical
blood flow
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Outcome_Physical
IOP
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Outcome_Physical
Visual function
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Participant_Condition
patients with primary open-angle glaucoma
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Participant_Condition
primary open-angle glaucoma ( OAG ) subjects .
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Participant_Sample-size
Sixteen ( 16 )
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Participant_Age
age , 63.5 +/- 10.8 years
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Participant_Sample-size
9
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Participant_Sex
male
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Participant_Sample-size
9
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Participant_Sample-size
7
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Participant_Condition
OAG patients