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document
[ Effect analysis on non-and-low response infants after revaccinated hepatitis B vaccine ] . OBJECTIVE To evaluate the booster immunization effect to non-and-low response children after 3 doses HepB immunization . METHODS Non-and-low response infants born in 2004 2005 administered 3 doses of HepB at 0 , 1 , 6 months in Guangzhou , Beijing and Zhejiang were divided into 4 groups randomly , and boosted 3 dose of 4 different types of HepB at 0 , 1 , 6 months . RESULTS The GMC of non-and-low response children in group A ( before booster ) , group B ( after 1 dose booster ) and group C ( after 3 dose booster ) were 18.66 mIUml , 88.82 mIU/ml , 178.24 mIU/ml respectively ; the proportion of non-responders in three groups were 20.4 % , 9.1 % , 1.9 % respectively . In 103 non-and-low response children , proportion of titers of more than 100 mIU/ml of group B and group C were 61.2 % and 84.5 % , and there was statistical significant difference ( chi2 = 14.13 , P < 0.01 ) . The GMC after 3 doses revaccination with four kinds of HepB , included 5 microg HepB-Y , 10 microg HepB-Y , l0 microg HepB-CHO , 10 microg HepB-HY were 168.8 mJU/ml , 174.7 mIU/ml , 184.9 mIU/ml , 182.9 mIU/ml respectively . Proportion of titers of more than 100 mIU/ml for four kinds HepB were 79.0 % , 85.7 % , 88.2 % and 84.6 % respectively , and there was no significant difference ( chi2 = 0.75 , 0.05 ) . CONCLUSION There were no different of seroconversion rate between study population received 1 dose and 3 dose booster ( P > 0.05 ) , but high titer was observed after 3 dose booster . The four kinds of HepB , including 5 microg HepB-Y,10 microg HepB-Y , 10 microg HepB-CHO , 10 microg HepB-HY had the same immunization effect after 3 doses revaccination at 0 , 1 , 6 months to non-and-low response children .
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Intervention_Pharmacological
hepatitis B vaccine
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Intervention_Pharmacological
3 doses of HepB
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Intervention_Pharmacological
HepB
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Intervention_Pharmacological
revaccination
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Intervention_Pharmacological
HepB-Y
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Intervention_Pharmacological
HepB-Y
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Intervention_Pharmacological
HepB-CHO
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Intervention_Pharmacological
HepB-HY
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Outcome_Other
[ Effect analysis
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Outcome_Physical
booster immunization effect
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Outcome_Physical
proportion of titers
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Outcome_Physical
Proportion of titers
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Outcome_Physical
seroconversion rate
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Participant_Age
infants
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Participant_Condition
hepatitis B
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Participant_Age
infants
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Participant_Age
2004 2005
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Participant_Sample-size
103
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Participant_Age
children