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document
Cimetidine as an immunomodulator in the treatment of herpes zoster . As there is evidence of a possible immunoregulatory role for H2-histamine receptor antagonists , we carried out a prospective randomized trial to evaluate the in vivo and in vitro effect of cimetidine , an H2-blocker , in the treatment of herpes zoster infection . Cimetidine treatment shortened the median interval until the first decrease in pain , the median interval until the complete resolution of pain and promoted faster complete healing of skin lesions than symptomatic treatment . The immunological trends observed in vitro support an important role for histamine in the induction of immunosuppression , as measured by the response to the mitogen phytohemagglutinin . This effect of histamine was antagonized by cimetidine .
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Intervention_Pharmacological
Cimetidine
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Intervention_Pharmacological
H2-histamine receptor antagonists
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Intervention_Pharmacological
cimetidine
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Intervention_Pharmacological
Cimetidine
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Intervention_Pharmacological
cimetidine
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Outcome_Pain
median interval until the first decrease in pain
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Outcome_Pain
median interval until the complete resolution of pain
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Outcome_Pain
faster
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Outcome_Physical
complete healing of skin lesions
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Participant_Condition
herpes zoster .