16061
document
Oscillatory potentials , retinopathy , and long-term glucose control in insulin-dependent diabetes . The main objective of the study was to assess effects of long-term lowering of glucosylated hemoglobin ( HbA1 % ) on neurosensory function in insulin-dependent diabetes . Individual ( OP-1 , OP-2 , OP-3 ) and summed ( OP-sum ) amplitudes of oscillatory potentials ( OPs ) of electroretinography were recorded at study start and 7-years later in 45 patients ( the Oslo study ) . As an overall 7-year change , amplitudes of OP-2 , OP-3 and OP-sum were reduced ( p < 0.0001-0.01 ) , retinopathy worsened ( p = 0.005 ) , intraocular pressure decreased ( p < 0.001 ) , systolic blood pressure increased ( p < 0.0002 ) , and glycemic control improved from HbA1 of 11.2 +/- 2.2 % at study start to a 7-year cumulative mean of 9.5 +/- 1.5 % ( p < 0.0001 ) . Multiple regression analysis did not identify any independent relations between change in OP-1 , OP-2 , OP-3 , OP-sum and change in glycemic control or background variables , including change in age and duration of diabetes . However , cross-sectional observations at 7 years showed negative correlations between all OPs and age ( p < 0.0001-0.003 ) , and between OP-3 and duration ( p = 0.003 ) and counts of microaneurysms ( p = 0.02 ) . The data suggest that various clinical background variables may influence individual and summed amplitudes of OPs differently . Reduced neurosensory retinal function ( OPs ) seemed to appear after 7-years , independently of vascular defects of retinopathy and long-term improvement in glucose control .
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Intervention_Physical
glucosylated hemoglobin ( HbA1 % )
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Intervention_Physical
Individual ( OP-1 , OP-2 , OP-3 ) and summed ( OP-sum ) amplitudes of oscillatory potentials ( OPs ) of electroretinography were recorded
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Outcome_Physical
glucosylated hemoglobin
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Outcome_Physical
amplitudes of OP-2 , OP-3 and OP-sum
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Outcome_Physical
retinopathy
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Outcome_Physical
intraocular pressure
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Outcome_Physical
systolic blood pressure
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Outcome_Physical
glycemic control
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Outcome_Physical
OP-1 , OP-2 , OP-3 , OP-sum
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Outcome_Physical
change in glycemic control
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Outcome_Physical
background variables
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Outcome_Physical
OPs
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Outcome_Physical
OP-3
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Outcome_Physical
duration
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Outcome_Physical
counts of microaneurysms
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Outcome_Physical
Reduced neurosensory retinal function ( OPs )
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Outcome_Physical
vascular defects of retinopathy
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Outcome_Physical
long-term improvement in glucose control .
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Participant_Condition
Oscillatory
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Participant_Condition
retinopathy
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Participant_Condition
insulin-dependent diabetes
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Participant_Condition
insulin-dependent diabetes
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Participant_Sample-size
45