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document
Fusidic acid prophylaxis before cataract surgery : patient self-administration . In a placebo-controlled , randomised , double-blind clinical trial , the authors evaluated the efficacy of patient-administered 1 % fusidic acid viscous eye drops in clearing the commonest organisms causing pseudophakic endophthalmitis ( Staphylococcus epidermidis and aureus ) from the lids and conjunctivae of 79 patients before cataract surgery . The treatment group self-administered fusidic acid viscous eye drops four times daily for seven days before surgery ; the placebo group received inert ophthalmic drops . Fellow eyes of both groups remained untreated as a natural control . Lower fornix and lid margin cultures were taken from both eyes before and after treatment . Before treatment , there was no statistical difference in organism counts between the groups . After treatment , eyes receiving fusidic acid were more likely to be free of clinically relevant Staphylococcus spp . than all pre-treatment eyes ( for lids , P < 0.001 ; conjunctivae , P = 0.02 ) . A highly significant ( P < 0.001 ) number of lid margins were rendered 'clinically clean ' ( i.e. , 0-49 organisms/swab ) by fusidic acid when compared with untreated eyes . Treatment also effectively ( P < 0.05 ) reduced the numbers of bacteria isolated from conjunctivae . This study indicates that there is a highly significant reduction of Staphylococcus spp . ( P < 0.001 ) , non-Staphylococcus spp . ( P < 0.001 ) and attainment of sterile eyes ( P < 0.001 ) at operation gained by patient self-administration of 1 % fusidic acid four times daily for seven days before surgery .
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Intervention_Pharmacological
fusidic acid viscous eye drops
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Intervention_Pharmacological
fusidic acid
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Intervention_Control
inert ophthalmic drops .
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Intervention_Pharmacological
fusidic acid
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Outcome_Physical
organism counts
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Outcome_Physical
number of lid margins
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Outcome_Physical
numbers of bacteria isolated from conjunctivae
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Participant_Sample-size
79 patients