86387
document
Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency . Epidemiologic and experimental data suggest that a high dietary intake of long-chain polyunsaturated n-3 fatty acids may reduce the risk of atherothrombotic disease . In a randomized , controlled study , 610 patients undergoing coronary artery bypass grafting were assigned either to a fish oil group , receiving 4 g/day of fish oil concentrate , or to a control group . All patients received antithrombotic treatment , either aspirin or warfarin . Their diet and serum phospholipid fatty acid profiles were monitored . The primary end point was 1-year graft patency , which was assessed by angiography in 95 % of patients . Vein graft occlusion rates per distal anastomoses were 27 % in the fish oil group and 33 % in the control group ( odds ratio 0.77 , 95 % confidence interval , 0.60 to 0.99 , p = 0.034 ) . In the fish oil group , 43 % of the patients had > or = 1 occluded vein graft ( s ) compared with 51 % in the control group ( odds ratio 0.72 , 95 % confidence interval , 0.51 to 1.01 , p = 0.05 ) . Moreover , in the entire patient group , there was a significant trend to fewer patients with vein graft occlusions with increasing relative change in serum phospholipid n-3 fatty acids during the study period ( p for linear trend = 0.0037 ) . Thus , in patients undergoing coronary artery bypass grafting , dietary supplementation with n-3 fatty acids reduced the incidence of vein graft occlusion , and an inverse relation between relative change in serum phospholipid n-3 fatty acids and vein graft occlusions was observed .
86388
Intervention_Pharmacological
n-3 fatty acids
86389
Intervention_Pharmacological
fish oil group
86390
Intervention_Pharmacological
4 g/day of fish oil concentrate
86391
Intervention_Control
control group
86392
Intervention_Pharmacological
antithrombotic treatment
86393
Intervention_Pharmacological
aspirin
86394
Intervention_Pharmacological
warfarin
86395
Intervention_Pharmacological
fish oil
86396
Intervention_Pharmacological
fish oil
86397
Intervention_Pharmacological
n-3 fatty acids
86398
Outcome_Physical
graft patency
86399
Outcome_Physical
Vein graft occlusion rates per distal anastomoses
86400
Outcome_Other
> or = 1 occluded vein graft ( s )
86401
Outcome_Physical
serum phospholipid n-3 fatty acids
86402
Outcome_Physical
serum phospholipid n-3 fatty acids and vein graft occlusions
86403
Participant_Condition
coronary artery bypass graft
86404
Participant_Sample-size
610
86405
Participant_Condition
coronary artery bypass grafting
86406
Participant_Condition
antithrombotic treatment
86407
Participant_Condition
coronary artery bypass grafting