11357
document
Secretin and sleep in children with autism . The objectives of this pilot study were 1 ) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism , and 2 ) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism . Participants were a subset of subjects from two double blind , placebo-control , multi-center clinical trials . One trial , the UC Irvine study , assessed the effects of porcine secretin vs. saline infusions on children 's behavior , language and IQ . The UC Davis trial assessed the effects of synthetic human secretin vs. saline infusions on behavior , language and gastrointestinal function . The sleep study enrolled some of the children from each of the two trials to observe possible secretin effects on sleep . To examine sleep , the UC Irvine trial used the Children 's Sleep Habits Questionnaire and daily sleep diaries , whereas the UC Davis study used home-recorded time-lapse videosomnography . Because of the small sample size , the results from both trials are preliminary . They suggest that secretin , porcine or synthetic , does not improve sleep-wake state organization dramatically .
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Intervention_Pharmacological
Secretin
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Intervention_Pharmacological
secretin
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Intervention_Pharmacological
porcine secretin
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Intervention_Control
saline infusions
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Intervention_Pharmacological
synthetic human secretin
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Intervention_Control
saline infusions
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Intervention_Pharmacological
secretin , porcine or synthetic
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Outcome_Mental
behavior , language
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Outcome_Mental
IQ
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Outcome_Mental
behavior , language
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Outcome_Physical
gastrointestinal function .
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Outcome_Mental
Children 's Sleep Habits Questionnaire and daily sleep diaries
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Outcome_Mental
home-recorded time-lapse videosomnography
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Outcome_Mental
sleep-wake state organization