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document
Effect of nimodipine upon electroencephalographic vigilance in elderly persons with minor impairment of brain functions . 10 volunteers ( 61-78 years ) with minor impairment of brain function were given placebo , 40 mg and 60 mg nimodipine ( Nimotop ) in single doses with intervals of 3 medication-free days between medications under double-blind conditions . Consecutive 2-s epochs of a 10-min EEG record ( resting conditions ) of F3/C3-F4/C4-P3/01-P4/02 were subjected to FFT ( Fast Fourier Transform ) . Using the information given by the 4 leads for each minute of recording the number of epochs which correspond to a stage A or non-A were determined . In order to evaluate subtle effects on electroencephalographic vigilance within stage A , also the anterior-posterior and left-right relations of absolute alpha-power were calculated . Since previous findings suggested that a nimodipine effect can only be demonstrated when individual differences in the baseline-EEG are considered , the subjects were subdivided in equal subgroups according to the number of non-A epochs under placebo . The rationale for this is the finding that in geriatric patients two electroencephalographically distinguishable forms of dissolution can be observed . Under both 40 mg and 60 mg nimodipine the subgroup with a prevalence of non-A epochs ( poor alpha-activity ) showed a decrease of non-A epochs ; the subgroup with a prevalence of A-epochs ( abundant alpha-activity ) , an increase . Opposite results for the two subgroups were also obtained for the left-right relations of alpha-power over the anterior regions . Under 40 mg nimodipine the subgroup with poor alpha-activity showed a shift to the left ; the subgroup with abundant alpha-activity to the right . Under 60 mg nimodipine both subgroups showed a shift to the left . The results confirm findings that nimodipine stabilizes electroencephalographic vigilance at a medium level . Moreover they suggest a dose dependence of the effect , i.e. , at higher doses nimodipine seems to act as a sedative .
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Intervention_Control
placebo
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Intervention_Pharmacological
nimodipine ( Nimotop )
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Intervention_Physical
10-min EEG
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Intervention_Pharmacological
nimodipine
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Outcome_Physical
electroencephalographic vigilance
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Outcome_Physical
number of epochs
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Outcome_Physical
anterior-posterior and left-right relations of absolute alpha-power
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Outcome_Physical
baseline-EEG
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Outcome_Other
forms
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Outcome_Physical
non-A epochs
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Outcome_Physical
non-A epochs
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Outcome_Physical
prevalence of A-epochs ( abundant alpha-activity )
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Outcome_Physical
left-right relations of alpha-power
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Outcome_Physical
alpha-activity
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Outcome_Other
shift to the left
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Outcome_Other
alpha-activity to the right
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Outcome_Physical
shift to the left
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Outcome_Physical
electroencephalographic vigilance
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Participant_Condition
elderly persons with minor impairment of brain functions . 10 volunteers ( 61-78 years ) with minor impairment of brain function