69563
document
Concentrated parenteral nutrition solutions and central venous catheter complications in preterm infants . UNLABELLED Standardised , concentrated neonatal parenteral nutrition ( PN ) regimens can overcome early nutritional deficits in very preterm infants . A PN regimen with increased macronutrient content ( standardised , concentrated , added macronutrients parenteral ( SCAMP ) ) has been shown to improve early head growth in a randomised controlled trial . Line complications including late onset sepsis were secondary outcomes of this study . Infants were started on standardised , concentrated PN at birth and randomised at 2-5 days to either switch to SCAMP or remain on control PN . Central venous catheter ( CVC ) , blood culture ( BC ) and inflammatory marker data were collected for the 28-day intervention period . 150 infants were randomised with mean ( SD ) birth weight ( g ) of 900 ( 158 ) versus 884 ( 183 ) in SCAMP ( n=74 ) and control ( n=76 ) groups , respectively . There were no differences in CVC use/type or duration or in positive/negative BC with/without associated C reactive protein rise in SCAMP versus control groups . Increasing the macronutrient content of a standardised , concentrated neonatal PN regimen does not increase CVC complication rates . TRIAL REGISTRATION NUMBER ISRCTN 76597892 .
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Intervention_Pharmacological
parenteral nutrition
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Intervention_Pharmacological
concentrated neonatal parenteral nutrition ( PN ) regimens
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Intervention_Pharmacological
standardised , concentrated , added macronutrients parenteral ( SCAMP ) )
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Intervention_Physical
concentrated PN
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Intervention_Pharmacological
SCAMP
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Intervention_Control
remain on control PN .
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Intervention_Pharmacological
SCAMP
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Intervention_Pharmacological
PN
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Outcome_Adverse-effects
central venous catheter complications
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Outcome_Adverse-effects
Line complications
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Outcome_Adverse-effects
late onset sepsis
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Outcome_Physical
Central venous catheter ( CVC ) , blood culture ( BC ) and inflammatory marker data
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Outcome_Physical
birth weight
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Outcome_Physical
CVC use/type or duration or in positive/negative BC with/without associated C reactive protein rise
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Outcome_Adverse-effects
CVC complication rates .
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Participant_Condition
central venous catheter complications
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Participant_Age
preterm infants
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Participant_Age
very preterm infants
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Participant_Sample-size
150
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Participant_Sample-size
n=74
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Participant_Sample-size
n=76