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document
Hodgkin 's disease in childhood and adolescence : results of chemotherapy-radiotherapy in clinical stages IA-IIB . From April 1972 to May 1980 , 72 children and adolescents ( aged 5 to 19 years old , median 16 ) with Hodgkin 's disease , clinical stages IA-IIB ( IA , 18 ; II2A , two areas involved on the same side of the diaphragm , 23 ; II3+A , three areas or more , 16 ; IIB , 15 ) were prospectively treated in two successive clinical trials ( H 72 and H 77 ) . Clinical stages IA and II2A received three courses of mechlorethamine , Oncovin , procarbazine , and prednisone ( MOPP ) and supradiaphragmatic radiotherapy ( 40 Gy ) , and no laparotomy was performed . Clinical stages II3+A and IIB received either six cycles of MOPP ( H 72 ) , three cycles of MOPP , or three cycles of CCNU , vinblastine , procarbazine , and prednisone ( CVPP ) ( H 77 ) and subsequently had a laparotomy followed by supradiaphragmatic radiotherapy and a lumboaortic field if results of laparotomy were positive . Patients without evidence of mediastinal involvement did not have mediastinal radiotherapy . At the completion of therapy , the disease in 70 of 72 patients was in complete remission ( one failure , one death during treatment ) . Eight patients relapsed ( in situ , 1 ; marginal , 1 ; nonirradiated subdiaphragmatic area , 6 ) after three to 57 months of complete remission ( median 20 months ) ; one patient died after relapse . There were three deaths after complete remission of the disease ( infection , two ; acute nonlymphocytic leukemia [ ANLL ] , one ) . As of June 1984 the median follow-up was 82 months ( range , 49 to 145 months ) , the actuarial probabilities for survival and freedom from relapse for all patients being 91.6 % and 87.6 % , respectively . There was no statistical difference according to clinical stage , age ( greater than 15 or less than 15 years ) , sex , or number of cycles of chemotherapy ( six or three ) . Bone growth defects related to radiotherapy were reduced particularly in the 29 patients who did not receive mediastinal radiotherapy . None of these patients had a mediastinal relapse . Azoospermia was the rule for the male patients studied , but young girls and young women retained reproductive integrity .
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Intervention_Pharmacological
mechlorethamine , Oncovin , procarbazine , and prednisone ( MOPP )
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Intervention_Physical
supradiaphragmatic radiotherapy ( 40 Gy )
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Intervention_Physical
no laparotomy
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Intervention_Pharmacological
MOPP
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Intervention_Pharmacological
CCNU , vinblastine , procarbazine
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Intervention_Pharmacological
prednisone
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Intervention_Surgical
laparotomy
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Intervention_Physical
supradiaphragmatic radiotherapy
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Outcome_Adverse-effects
failure
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Outcome_Mortality
death
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Outcome_Adverse-effects
relapsed
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Outcome_Adverse-effects
deaths
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Outcome_Physical
nonlymphocytic leukemia
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Outcome_Mortality
the actuarial probabilities for survival and freedom from relapse
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Outcome_Other
number of cycles of chemotherapy
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Outcome_Adverse-effects
Bone growth defects related to radiotherapy
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Outcome_Physical
mediastinal relapse
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Outcome_Physical
Azoospermia
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Participant_Condition
Hodgkin 's disease
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Participant_Age
childhood
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Participant_Age
adolescence
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Participant_Sample-size
72
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Participant_Age
children
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Participant_Age
adolescents
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Participant_Condition
Hodgkin 's disease
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Participant_Condition
mediastinal involvement