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document
Changes in beta-carotene levels by long-term administration of natural beta-carotene derived from Dunaliella bardawil in humans . Long-term administration of a beta-carotene preparation derived from Dunaliella bardawil , a beta-carotene-rich algae , was studied in healthy young male volunteers . The daily administration of 60 mg of the beta-carotene preparation ( 30 mg of all-trans beta-carotene and 30 mg of 9-cis beta-carotene ) was performed and beta-carotene concentrations were determined in the plasma , red blood cells ( RBC ) , platelets ( PLT ) , and mononuclear cells ( MN ) . The all-trans beta-carotene level increased four- , two- , and threefold the baseline in plasma , PLT , and MN , respectively . Basal levels of 9-cis beta-carotene in plasma , PLT , and MN were low and found as one-tenth , one-fifth , and one-fifth of all-trans beta-carotene , which increased three- , two- , and 1.5-fold the baseline , respectively . Plasma and RBC alpha-tocopherol levels were not changed by the intake of beta-carotene . No side effects or toxicities were documented in any of the subjects during the administration period . In conclusion , the bioavailability of beta-carotene derived from Dunaliella bardawil was preferential for all-trans beta-carotene , although a small amount of the 9-cis form was detected in the plasma and blood cells .
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Intervention_Pharmacological
natural beta-carotene
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Intervention_Pharmacological
beta-carotene preparation
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Intervention_Pharmacological
beta-carotene-rich algae
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Intervention_Pharmacological
60 mg of the beta-carotene preparation
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Outcome_Physical
plasma
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Outcome_Physical
red blood cells ( RBC )
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Outcome_Physical
platelets ( PLT ) ,
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Outcome_Physical
mononuclear cells ( MN )
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Outcome_Physical
all-trans beta-carotene level
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Outcome_Physical
plasma
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Outcome_Physical
PLT
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Outcome_Physical
MN
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Outcome_Physical
Basal levels of 9-cis beta-carotene in plasma , PLT , and MN
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Outcome_Physical
Plasma and RBC alpha-tocopherol levels
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Outcome_Adverse-effects
No side effects or toxicities
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Participant_Condition
humans