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document
[ Comparative effects of nebivolol and valsartan on atrial electromechanical coupling in newly diagnosed stage 1 hypertensive patients ] . OBJECTIVES Hypertension is an important cardiovascular risk factor for the development of atrial fibrillation ( AF ) . Increased atrial electromechanical coupling time interval measured by tissue Doppler is accepted as an important factor for prediction of AF development in hypertensive patients . The aim of this study was to compare the effects of valsartan , an angiotensin receptor blocker , and nebivolol , a beta-blocker , on atrial electromechanical coupling in newly diagnosed stage 1 hypertensive patients . STUDY DESIGN The study included 60 newly diagnosed stage 1 hypertensive patients with no other systemic disease . The patients were randomized to receive nebivolol 5 mg ( 30 patients ; 21 women , 9 men ; mean age 48.4 ± 11.4 years ) and valsartan 160 mg ( 30 patients ; 21 women , 9 men ; mean age 49.8 ± 11.3 years ) . All the patients underwent tissue Doppler echocardiographic examination before and three months after treatment to compare the effects of the two drugs on atrial electromechanical coupling . RESULTS Baseline blood pressures , electrocardiographic and echocardiographic findings , and atrial electromechanical coupling were similar in both groups ( p > 0.05 ) . Both drugs significantly reduced blood pressure after treatment , with similar efficacy ( p > 0.05 ) . Atrial electromechanical coupling time intervals showed significant decreases in both groups . CONCLUSION Prolonged interatrial electromechanical time intervals in hypertensives are improved with antihypertensive treatment .
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Intervention_Pharmacological
nebivolol
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Intervention_Pharmacological
valsartan
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Intervention_Pharmacological
valsartan
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Intervention_Pharmacological
nebivolol
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Intervention_Pharmacological
nebivolol 5 mg
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Outcome_Physical
atrial electromechanical coupling
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Outcome_Physical
atrial fibrillation ( AF ) .
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Outcome_Physical
AF development