14483
document
The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure , plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients . In this study eicosapentaenoic acid ( EPA ) and docosahexaenoic acid ( DHA ) were given in a cumulative manner , every 6 weeks , starting with 10 mg , then 100 mg , 1000 mg and 10,000 mg EPA daily to mild to moderate essential hypertensive black patients . The corresponding DHA doses were 3 , 33 , 333 and 3333 mg. A control group was given olive oil as placebo for the entire 24 weeks . The placebo group had lower diastolic and systolic blood pressures after 24 weeks than the EPA and DHA group . No effect was seen on plasma triglycerides , cholesterol , HDL-cholesterol and gamma-glutamyltranspeptidase at any stage of the trial . In the EPA group plasma free-EPA increased significantly from 1000 mg onwards and plasma free-arachidonic acid ( AA ) decreased after 1000 mg EPA . No other plasma free essential fatty acid changed during the trial , although the HDL : cholesterol increased slightly but non-significantly with an increase in EPA and DHA . No significant changes in diet pattern or body mass was observed . It is therefore concluded that EPA and DHA supplementation had no beneficial effects in mild to moderate essential hypertensive black patients except for a lowering of plasma AA .
14484
Intervention_Pharmacological
eicosapentaenoic
14485
Intervention_Physical
docosahexaenoic acid
14486
Intervention_Pharmacological
eicosapentaenoic acid ( EPA )
14487
Intervention_Pharmacological
docosahexaenoic acid ( DHA )
14488
Intervention_Pharmacological
EPA
14489
Intervention_Pharmacological
DHA
14490
Intervention_Control
olive oil as placebo
14491
Intervention_Control
placebo
14492
Intervention_Pharmacological
EPA
14493
Intervention_Pharmacological
DHA
14494
Intervention_Pharmacological
EPA
14495
Intervention_Pharmacological
EPA
14496
Intervention_Pharmacological
EPA
14497
Intervention_Pharmacological
DHA
14498
Intervention_Pharmacological
EPA
14499
Intervention_Pharmacological
DHA supplementation
14500
Outcome_Physical
blood pressure , plasma lipid profile and diet pattern
14501
Outcome_Physical
lower diastolic and systolic blood pressures
14502
Outcome_Physical
plasma triglycerides , cholesterol , HDL-cholesterol and gamma-glutamyltranspeptidase
14503
Outcome_Physical
plasma free-EPA
14504
Outcome_Physical
plasma free-arachidonic acid ( AA )
14505
Outcome_Physical
plasma free essential fatty acid
14506
Outcome_Physical
HDL : cholesterol
14507
Outcome_Physical
EPA and DHA
14508
Outcome_Physical
diet pattern or body mass
14509
Outcome_Physical
lowering of plasma AA
14510
Participant_Condition
mild to moderate essential hypertensive black patients .