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document
The incidence of first-dose hypotension with quinapril in patients with mild to moderate hypertension . A total of 2242 patients with mild to moderate hypertension ( diastolic pressure 95-120 mmHg ) were randomised on a double-blind basis to receive a single dose of placebo , 5 mg quinapril or 10 mg quinapril . Patients were identified who : ( a ) met the blood pressure ( BP ) criteria for first-dose hypotension ( sitting or standing systolic BP < 100 mmHg , or a fall in systolic BP > or = 20 mmHg on standing ) ; ( b ) had symptoms suggestive of hypotension ; and ( c ) met the BP criteria and had symptoms . In all three classifications there were no statistically significant differences between the incidences in placebo and combined active treatment groups , or between those in the two quinapril groups . No associated serious adverse events were reported . In the low-risk population studied , it would appear that the incidence of first-dose hypotension with quinapril is similar to placebo and is not dose-related .
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Intervention_Pharmacological
quinapril
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Intervention_Control
placebo
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Intervention_Pharmacological
quinapril
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Intervention_Pharmacological
quinapril
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Outcome_Physical
blood pressure
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Outcome_Adverse-effects
associated serious adverse events
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Participant_Condition
mild to moderate hypertension
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Participant_Sample-size
2242
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Participant_Condition
mild to moderate hypertension
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Participant_Condition
sitting or standing systolic BP < 100 mmHg
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Participant_Condition
a fall in systolic BP > or = 20 mmHg on standing
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Participant_Condition
symptoms suggestive of hypotension
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Participant_Condition
low-risk population