84283
document
Sodium kinetics in white and black normotensive subjects : possible relevance to salt-sensitive hypertension . The hypothesis that sodium ( Na ) kinetics are not a first order process was tested . Twelve normotensive white and 12 normotensive black men were given 10 , 200 , and 400 mmol/d Na as the chloride salt for 7 days in random order . All urine made was collected . No effect of Na intake on blood pressure was identified in either whites or blacks . The half-life ( T1/2 ) with decreasing Na intake to 10 mmol/d was 1.08 days in whites and 1.65 days in blacks ( p = not significant [ NS ] ) . With increasing Na intake , T1/2 increased in both whites and blacks ; at the 400 mmol/d intake , the T1/2 for whites was 2.88 days and for blacks was 5.81 days ( p < 0.05 ) . At that intake , whites accumulated 385 +/- 153 mmol compared with 909 +/- 153 mmol for blacks ( p < 0.05 ) . The data showed that T1/2 increases with increasing Na intake and is , therefore , dose-dependent or " zero " order . The effect of dose is more prominent in blacks than in whites ; blacks accumulate more Na with increasing Na intake than whites . These data may have relevance for the pathogenesis of salt-sensitive hypertension in blacks .
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Intervention_Pharmacological
sodium
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Intervention_Pharmacological
Na as the chloride salt
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Intervention_Pharmacological
Na
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Intervention_Pharmacological
Na
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Intervention_Pharmacological
Na
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Intervention_Pharmacological
Na
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Intervention_Pharmacological
Na
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Intervention_Pharmacological
Na
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Outcome_Physical
blood pressure
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Outcome_Physical
half-life ( T1/2 )
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Outcome_Physical
T1/2 increased
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Outcome_Physical
accumulated
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Outcome_Physical
T1/2 increases
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Outcome_Other
effect
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Outcome_Physical
accumulate more Na
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Participant_Sample-size
Twelve normotensive white
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Participant_Sample-size
12 normotensive black men