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document
Unopposed estrogen increases total plasma factor VII , but not active factor VII -- a short-term placebo-controlled study in healthy postmenopausal women . Estrogen therapy may increase the risk of arterial thromboembolism , at least in the short term . In a randomized , double-blind and placebo-controlled study in 25 healthy postmenopausal women ( 52.5 +/- 2.8 years ) , we therefore examined the short-term effect of unopposed estrogen on the fasting and fat-load-stimulated plasma levels of total factor VII versus active factor VII . Plasma total factor VII was measured by use of a chromogenic assay ; plasma active FVII by a recently developed method using truncated tissue factor . As compared to placebo , 8 weeks of oral 17beta-estradiol ( 2 mg daily ) increased the mean fasting and postprandial plasma levels of total factor VII by 17 and 21 % points , respectively ( both P < 0.01 ) , but did not affect the fasting and/or postprandial plasma levels of active factor VII ( mean change both 0.05 ng/mL ; P > 0.35 ) . Furthermore , the change in the fasting level of total factor VII after therapy was not associated with the change in the fasting level of active factor VII ( r = 0.27 ; P = 0.21 ) . These findings argue against the idea that elevated levels of total factor VII underlie an increased risk of arterial thromboembolism in postmenopausal women using unopposed estrogen replacement .
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Intervention_Pharmacological
Unopposed estrogen
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Intervention_Control
placebo-controlled
5189
Intervention_Pharmacological
Estrogen therapy
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Intervention_Pharmacological
unopposed estrogen
5191
Intervention_Control
placebo
5192
Intervention_Pharmacological
oral 17beta-estradiol
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Intervention_Pharmacological
unopposed estrogen replacement .
5194
Outcome_Physical
Plasma total factor VII
5195
Outcome_Physical
mean fasting and postprandial plasma levels of total factor VII
5196
Outcome_Physical
fasting and/or postprandial plasma levels of active factor VII
5197
Outcome_Physical
change in the fasting level of total factor VII
5198
Outcome_Physical
change in the fasting level of active factor VII
5199
Outcome_Physical
levels of total factor VII
5200
Outcome_Physical
risk of arterial thromboembolism
5201
Participant_Condition
healthy postmenopausal
5202
Participant_Sex
women
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Participant_Sample-size
25
5204
Participant_Condition
healthy postmenopausal
5205
Participant_Sex
women
5206
Participant_Age
52.5 +/- 2.8
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Participant_Condition
postmenopausal
5208
Participant_Sex
women