79464
document
Diazoxide and labetalol in acute hypertension during haemodialysis . The antihypertensive effect of the peripheral vasodilator diazoxide in 13 patients and the alpha-beta adrenoceptor blocking agent labetalol in 12 patients were compared in 46 severe acute hypertensive episodes during haemodialysis . A single dose of diazoxide 150 mg or labetalol 50 mg was effective in 74 % and 70 % of the hypertensive episodes , respectively . In the diazoxide-treated patients blood pressure fell from 192 +/- 3/115 +/- 4 mmHg to 141 +/- 8/85 +/- 4 mmHg 2 h after injection . In 7 hypertensive episodes a second dose of diazoxide 150 mg was given 60 +/- 11 min after the first injection . The reduction in mean arterial blood pressure at the end of haemodialysis was 21.5 +/- 2.6 % in patients treated with a single dose and 24.8 +/- 3.5 % in patients treated with the repeated dose of diazoxide . In the labetalol-treated patients blood pressure in 17 instances fell from 198 +/- 5/104 +/- 4 mmHg to 143 +/- 7/89 +/- 5 mmHg 180 min following injection of labetalol 50 mg . In 6 episodes a second dose labetalol 50 mg was given 41 +/- 9 min after the first injection . At the end of haemodialysis the decrease in mean arterial blood pressure was 17.2 % in patients treated with a single dose and 18 +/- 5 % in patients given the repeated dose of labetalol . The reduction in blood pressure caused by diazoxide was slightly greater than that due to labetalol . At the end of haemodialysis the percentage reduction in mean arterial blood pressure was 23 +/- 2 % in the diazoxide-treated group and 17 +/- 2 % after labetalol . ( ABSTRACT TRUNCATED AT 250 WORDS )
79465
Intervention_Pharmacological
Diazoxide
79466
Intervention_Pharmacological
labetalol
79467
Intervention_Pharmacological
peripheral vasodilator diazoxide
79468
Intervention_Pharmacological
alpha-beta adrenoceptor blocking agent labetalol
79469
Intervention_Pharmacological
diazoxide 150 mg
79470
Intervention_Pharmacological
labetalol 50 mg
79471
Intervention_Pharmacological
diazoxide-treated
79472
Intervention_Pharmacological
diazoxide
79473
Intervention_Pharmacological
diazoxide
79474
Intervention_Pharmacological
labetalol-treated
79475
Intervention_Pharmacological
labetalol
79476
Intervention_Pharmacological
labetalol
79477
Intervention_Pharmacological
labetalol
79478
Intervention_Pharmacological
diazoxide
79479
Outcome_Physical
blood pressure
79480
Outcome_Physical
mean arterial blood pressure
79481
Outcome_Physical
blood pressure
79482
Outcome_Physical
mean arterial blood pressure
79483
Outcome_Physical
blood pressure