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document
Effect of m-chlorophenylpiperazine on plasma homovanillic acid concentrations in healthy subjects . In view of the abundant anatomical and functional interactions between serotonin and dopamine systems , this study examined the effect of the serotonin agonist , m-chlorophenylpiperazine ( mCPP ) on plasma concentrations of the dopamine metabolite , homovanillic acid . Plasma prolactin levels , body temperature , and mCPP blood level were also measured . mCPP ( 0.35 mg/kg ) and placebo were administered orally to 10 healthy men in a randomized double-blind design . Variables were measured for 210 min after administration of capsules . mCPP raised prolactin and temperature as compared to placebo , but did not affect plasma homovanillic acid concentrations . Results suggest that mCPP does not alter dopamine function .
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Intervention_Pharmacological
m-chlorophenylpiperazine
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Intervention_Pharmacological
m-chlorophenylpiperazine ( mCPP )
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Intervention_Pharmacological
mCPP
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Intervention_Control
placebo
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Outcome_Adverse-effects
mCPP
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Outcome_Physical
mCPP does not alter dopamine function .
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Participant_Condition
healthy subjects .