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document
Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome . The neuropeptide oxytocin has recently been shown to enhance eye gaze and emotion recognition in healthy men . Here , we report a randomized double-blind , placebo-controlled trial that examined the neural and behavioral effects of a single dose of intranasal oxytocin on emotion recognition in individuals with Asperger syndrome ( AS ) , a clinical condition characterized by impaired eye gaze and facial emotion recognition . Using functional magnetic resonance imaging , we examined whether oxytocin would enhance emotion recognition from facial sections of the eye vs the mouth region and modulate regional activity in brain areas associated with face perception in both adults with AS , and a neurotypical control group . Intranasal administration of the neuropeptide oxytocin improved performance in a facial emotion recognition task in individuals with AS . This was linked to increased left amygdala reactivity in response to facial stimuli and increased activity in the neural network involved in social cognition . Our data suggest that the amygdala , together with functionally associated cortical areas mediate the positive effect of oxytocin on social cognitive functioning in AS .
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Intervention_Pharmacological
Oxytocin
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Intervention_Pharmacological
neuropeptide oxytocin
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Intervention_Control
placebo-controlled
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Intervention_Pharmacological
intranasal oxytocin
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Intervention_Physical
functional magnetic resonance imaging
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Intervention_Pharmacological
oxytocin
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Intervention_Control
neurotypical control
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Intervention_Pharmacological
neuropeptide oxytocin
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Intervention_Pharmacological
oxytocin
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Outcome_Mental
facial emotion recognition
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Outcome_Mental
amygdala reactivity
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Outcome_Mental
eye gaze
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Outcome_Physical
and
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Outcome_Mental
emotion recognition
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Outcome_Mental
emotion recognition
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Outcome_Physical
modulate
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Outcome_Mental
regional activity in brain areas associated with face perception
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Outcome_Other
performance in a
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Outcome_Mental
facial emotion recognition
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Outcome_Other
task
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Outcome_Other
increased left
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Outcome_Mental
amygdala reactivity
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Outcome_Mental
increased activity
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Outcome_Mental
neural network
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Outcome_Mental
social cognitive functioning
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Participant_Age
adults
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Participant_Condition
asperger syndrome
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Participant_Condition
healthy men .