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document
The double-blind sham-controlled study of high-frequency rTMS ( 20 Hz ) for negative symptoms in schizophrenia : negative results . The high-frequency repetitive transcranial magnetic stimulation ( HF-rTMS ) over the prefrontal cortex is a promising method for the treatment of negative symptoms of schizophrenia . Using double-blind sham-controlled parallel design , we evaluated the effect of HF-rTMS over the left dorsolateral prefrontal cortex ( DLPFC ) on negative symptoms in patients with schizophrenia . Sixteen schizophrenia patients with predominantly negative symptoms on stable antipsychotic medication were treated with 20 Hz rTMS ( 90 % of motor threshold , 2000 stimuli per session ) over ten days within 2 weeks with six weeks follow-up . The effect was assessed using PANSS , CGI , MADRS and neuropsychological tests . We failed to find any significant effect of active rTMS . Sham rTMS showed a trend for improvement over time on positive and negative subscales of PANSS and MADRS . Between-group comparisons failed to reveal any significant differences on any rating scales except a positive subscale of PANSS after 8 weeks . Results from our study did not confirm that HF-rTMS over the left DLPCF affects the negative symptoms of schizophrenia and alternative rTMS approaches are discussed .
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Intervention_Physical
high-frequency rTMS
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Intervention_Physical
high-frequency repetitive transcranial magnetic stimulation ( HF-rTMS )
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Intervention_Physical
HF-rTMS
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Intervention_Physical
20 Hz rTMS
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Intervention_Physical
rTMS .
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Intervention_Physical
rTMS
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Outcome_Physical
PANSS , CGI , MADRS and neuropsychological tests .
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Outcome_Physical
active rTMS . Sham rTMS
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Outcome_Physical
improvement over time
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Outcome_Other
positive and negative subscales of PANSS and MADRS
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Outcome_Physical
.
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Outcome_Physical
rating scales
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Outcome_Physical
positive subscale of PANSS
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Outcome_Physical
HF-rTMS
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Outcome_Physical
DLPCF affects the negative symptoms of schizophrenia
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Participant_Condition
schizophrenia
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Participant_Condition
schizophrenia
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Participant_Condition
schizophrenia
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Participant_Sample-size
Sixteen
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Participant_Condition
schizophrenia