78097
document
A comparative trial of fixed ratio beta-adrenoceptor blocker and diuretic combination products in moderate hypertension . Two fixed ratio combination tablets , 10 mg pindolol combined with 5 mg clopamide and 100 mg metoprolol combined with 12.5 mg hydrochlorothiazide , were compared at two dose levels in a double-blind crossover trial in 10 previously untreated hypertensive patients . No significant difference was observed between resting blood pressure on the two combinations at either dose level . Exercise systolic pressure was lower after the pindolol/clopamide combination at low dose ( p less than 0.05 ) . The incidence of side-effects in this trial was high but proper comparison of the two products could not be made because of the small number of patients . It is suggested that combination products should be used only after patients have failed to respond adequately to a single agent .
78098
Intervention_Physical
beta-adrenoceptor blocker
78099
Intervention_Physical
diuretic combination products
78100
Intervention_Pharmacological
pindolol combined with 5 mg clopamide
78101
Intervention_Pharmacological
metoprolol combined with 12.5 mg hydrochlorothiazide
78102
Intervention_Pharmacological
pindolol/clopamide
78103
Outcome_Physical
resting blood pressure
78104
Outcome_Physical
Exercise systolic pressure
78105
Outcome_Adverse-effects
incidence of side-effects
78106
Participant_Condition
moderate hypertension
78107
Participant_Sample-size
10 previously untreated hypertensive patients