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document
The study of inhibiting systematic inflammatory response syndrome by applying xenogenic ( porcine ) acellular dermal matrix on second-degree burns . OBJECTIVE To investigate the influence of xenogenic ( porcine ) acellular dermal matrix on the systematic inflammatory reaction syndrome ( SIRS ) , and the reaction of burn patients to tissue damage upon application to second-degree burn wounds . METHOD Seventy-two cases of patients with acute second-degree burns were enrolled in the study . According to the total burn surface area ( TBSA ) and the treatment methods , we randomly divided the patients into four groups . Group A ( treatment group ) : patients with less than 30 % TBSA covered with xenogenic acellular dermal matrix . Group B ( control group ) : patients with less than 30 % TBSA covered with betadine ointment gauzes . Group C ( treatment group ) : patients with more than 30 % TBSA covered with porcine acellular dermal matrix . Group D ( control group ) : patients with more than 30 % TBSA covered with betadine ointment gauzes . Serum level of C-reactive protein ( CRP ) was measured by single radial immunodiffusion method on 1 , 4 , 7 and 14 days postburn . RESULTS The serum level of CRP in group A was significantly less than that of in group B ( P < 0.05 ) on days 4 , 7 and 14 . The serum level of CRP in group C increased slowly , descended quickly and was significantly less than that of in group D on days 4 , 7 and 14 . CONCLUSION The application of xenogenic ( porcine ) acellular dermal matrix on second-degree burn wound can decrease serum level of CRP of the patients , which may play an important role in reducing SIRS and sepsis incidence .
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Intervention_Pharmacological
xenogenic ( porcine ) acellular dermal matrix
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Intervention_Pharmacological
xenogenic ( porcine ) acellular dermal matrix
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Intervention_Pharmacological
xenogenic acellular dermal matrix .
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Intervention_Pharmacological
betadine ointment gauzes .
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Intervention_Pharmacological
porcine acellular dermal matrix .
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Intervention_Pharmacological
betadine ointment gauzes .
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Intervention_Pharmacological
xenogenic ( porcine ) acellular dermal matrix
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Outcome_Physical
serum level of CRP
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Outcome_Physical
serum level of CRP
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Outcome_Physical
serum level of CRP
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Participant_Condition
second-degree burns
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Participant_Condition
burn patients
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Participant_Condition
second-degree burn wounds
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Participant_Sample-size
Seventy-two
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Participant_Condition
acute second-degree burns
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Participant_Condition
second-degree burn wound