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document
Postoperative radiotherapy in breast cancer -- long-term results from the Oslo study . The long-term results of a randomized clinical trial evaluating the effect of postoperative radiotherapy as an adjuvant to radical mastectomy are presented . There were 1115 patients including 27 protocol deviants . The follow-up time is 11-20 years . In the first part a conventional roentgen unit was used , and in the second part a 60Co unit , with considerably increased dosage and altered treatment plan . Both types of radiation techniques lowered the incidence of loco-regional recurrences significantly , but had no significant influence on the overall survival . The relapse-free survival was significantly improved by 60Co radiation in Stage II patients , but was unaffected by radiation in the other subgroups . Regarding survival , Stage II patients with medially located tumors seemed to benefit more from 60Co radiation than those with lateral tumors . A significant increase in the number of deaths caused by myocardial infarction was observed in Stage I patients having 60Co radiation , indicating that the radiation dose to the heart is of significance .
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Intervention_Surgical
radiotherapy
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Intervention_Physical
postoperative radiotherapy
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Intervention_Surgical
radical mastectomy
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Intervention_Physical
conventional roentgen unit
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Intervention_Physical
60Co unit
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Intervention_Physical
60Co radiation
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Intervention_Physical
60Co radiation
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Outcome_Physical
incidence of loco-regional recurrences
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Outcome_Mortality
overall survival . The relapse-free survival
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Outcome_Mortality
survival
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Outcome_Mortality
number of deaths caused by myocardial infarction
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Participant_Condition
Oslo study .
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Participant_Condition
1115 patients including 27 protocol deviants .