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document
[ Effect of alanyl-glutamine in postoperative total parenteral nutrition on postoperative immunosuppression and morbidity . Preliminary results of a prospective randomized study ] . The impact of glutamine substitution on postoperative immunosuppression and morbidity was investigated in patients with surgical interventions and total parenteral nutrition in a prospective randomized trial . To analyze immune competence , the expression of CD3 , CD4 , and CD8 on lymphocytes and of HLA-DR and CD14 on monocytes as well as the plasma levels of IL-6 and IL-10 was evaluated before , 1 , 2 , 4 , and 7 days after surgery . A total of 34 patients have been included ( with glutamine : n = 18 ; without glutamine : n = 16 ) . Patients with glutamine substitution showed decreased systemic inflammation , significant faster compensation for postoperative immunosuppression and a lower incidence of postoperative complications . Patients without postoperative complications showed no significant differences in postoperative immunosuppression .
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Intervention_Pharmacological
alanyl-glutamine
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Intervention_Pharmacological
glutamine substitution
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Intervention_Pharmacological
with glutamine : n = 18 ; without glutamine :
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Intervention_Pharmacological
glutamine substitution
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Outcome_Other
immunosuppression
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Outcome_Other
morbidity
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Outcome_Physical
CD3 , CD4 , and CD8 on lymphocytes and of HLA-DR and CD14 on monocytes as well as the plasma levels of IL-6 and IL-10
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Outcome_Other
decreased systemic inflammation
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Outcome_Other
compensation for postoperative immunosuppression
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Outcome_Other
lower incidence of postoperative complications
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Outcome_Physical
immunosuppression
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Participant_Condition
patients with surgical interventions and total parenteral nutrition
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Participant_Sample-size
34
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Participant_Condition
glutamine
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Participant_Sample-size
18
93609
Participant_Condition
without glutamine
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Participant_Sample-size
16
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Participant_Condition
Patients with glutamine substitution