42447
document
Immunologic profiles of persons recruited for a randomized , placebo-controlled clinical trial of hookworm infection . Data from epidemiologic studies suggest that hookworm infections , in establishing an immunologic phenotype conducive to parasite survival , may protect against the development of allergic disease . We describe immunologic findings from a clinical study designed to investigate the safety of iatrogenic hookworm infection in participants with allergic rhinitis . The low , relatively safe level of hookworm infection used in this study was immunogenic , inducing eosinophilia and a significant specific IgG response . Importantly , no potentiation of IgE responses to the environmental allergens to which the participants were sensitized was seen . However , no evidence of systemic immune regulation was seen in infected participants . This finding may indicate that the level of infection or the frequency of infection may have to be altered in future trials to induce a therapeutically conducive immunologic phenotype .
42448
Intervention_Control
placebo-controlled
42449
Intervention_Physical
iatrogenic hookworm infection
42450
Intervention_Physical
hookworm infection
42451
Outcome_Physical
eosinophilia
42452
Outcome_Physical
specific IgG response .
42453
Outcome_Physical
IgE responses to the environmental allergens to which the participants were sensitized
42454
Outcome_Physical
systemic immune regulation
42455
Outcome_Physical
level of infection
42456
Outcome_Physical
frequency of infection