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document
Effect of interferon gamma on infection-related death in patients with severe injuries . A randomized , double-blind , placebo-controlled trial . OBJECTIVE To assess the efficacy of interferon gamma in reducing infection and death in patients sustaining severe injury . DESIGN Multicenter , randomized , double-blind , placebo-controlled trial with observation for 60 days and until discharge for patients with major infection on day 60 . SETTING Nine university-affiliated level 1 trauma centers . PATIENTS Four hundred sixteen patients with severe injuries , assessed by Injury Severity Score and degree of contamination . INTERVENTION Recombinant human interferon gamma , 100 micrograms , was administered subcutaneously once daily for 21 days ( or until patient discharge if prior to 21 days ) as an adjunct to standard antibiotic and supportive therapy . MAIN OUTCOME MEASURES Incidence of major infection , death related to infection , and death . RESULTS Infection rates were similar in both treatment groups ; however , patients treated with interferon gamma experienced fewer deaths related to infection ( seven [ 3 % ] vs 18 [ 9 % ] ; P = .008 ) and fewer overall deaths ( 21 [ 10 % ] vs 30 [ 14 % ] ; P = .17 ) . While 12 early deaths ( days 1 through 7 ) occurred in each treatment group , late death occurred in 18 placebo-treated patients and nine in interferon gamma-treated patients . The results were dominated by findings at one center , which had the highest enrollment and higher infection and death rates . Statistical analysis did not eliminate the possibility of an unidentified imbalance between arms as an explanation for the results . CONCLUSION Further evaluation is required to determine the validity of the observed reduction in infection-related deaths in patients treated with interferon gamma .
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Intervention_Pharmacological
interferon gamma
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Intervention_Physical
Recombinant human interferon gamma , 100 micrograms , was administered subcutaneously once daily for 21 days ( or until patient discharge if prior to 21 days ) as an adjunct to standard
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Intervention_Physical
supportive therapy
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Intervention_Pharmacological
interferon gamma-treated
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Intervention_Pharmacological
interferon gamma
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Outcome_Physical
Injury Severity Score and degree of contamination
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Outcome_Mortality
Incidence of major infection , death related to infection , and death .
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Outcome_Mortality
deaths
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Outcome_Mortality
deaths
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Outcome_Mortality
early deaths
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Outcome_Mortality
death
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Participant_Condition
patients with severe injuries .
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Participant_Condition
patients sustaining severe injury .