7597
document
Relationship between endogenous estrogen concentrations and serum cholesteryl ester transfer protein concentrations in Chinese women . BACKGROUND CETP plays an important role in HDL metabolism and in the reverse cholesterol transport pathway . METHODS The relationship between the changes of endogenous estrogen and the concentration of cholesteryl ester transfer protein ( CETP ) in the serum of Chinese women was investigated . Serum concentrations of estradiol ( E ( 2 ) ) , follicle-stimulating hormone ( FSH ) , CETP and lipid profile were determined in 196 Chinese women ( 52 premenopausal with ages ranging from 18 to 40 years , 57 perimenopausal from 41 to 60 years , and 87 postmenopausal from 61 to 81 years ) . RESULTS Serum CETP concentration was significantly lower in postmenopausal women compared with those in perimenopausal and premenopausal women ( 1.39+/-1.06 , 2.36+/-1.50 and 2.31+/-1.25 mg/l , respectively , P < 0.0001 ) . Even in the women around the menopausal , CETP concentration in postmenopause was significantly lower than that in premenopause ( 1.93+/-1.33 vs. 3.42+/-1.35 mg/l , P < 0.01 ) . In addition , CETP concentration had a highly positive correlation with serum concentration of E ( 2 ) ( r=0.243 , P < 0.001 ) , while negative correlation of CETP concentration with serum concentration of FSH was found ( r=-0.273 , P < 0.001 ) . CONCLUSIONS Estrogen may affect the concentration of CETP .
7598
Intervention_Pharmacological
endogenous estrogen concentrations
7599
Intervention_Pharmacological
serum cholesteryl ester
7600
Intervention_Physical
Serum concentrations of estradiol ( E ( 2 ) ) , follicle-stimulating hormone ( FSH ) , CETP and lipid profile were determined
7601
Outcome_Physical
Serum concentrations of estradiol ( E ( 2 ) )
7602
Outcome_Physical
follicle-stimulating hormone ( FSH )
7603
Outcome_Physical
CETP
7604
Outcome_Physical
lipid profile
7605
Outcome_Physical
Serum CETP concentration
7606
Outcome_Physical
CETP concentration
7607
Outcome_Physical
serum concentration
7608
Outcome_Physical
CETP concentration
7609
Outcome_Physical
serum concentration of FSH
7610
Outcome_Physical
concentration of CETP
7611
Participant_Condition
Chinese
7612
Participant_Sex
women
7613
Participant_Sample-size
196
7614
Participant_Condition
Chinese
7615
Participant_Sex
women
7616
Participant_Sample-size
52
7617
Participant_Condition
premenopausal
7618
Participant_Age
ages ranging from 18 to 40 years
7619
Participant_Sample-size
57
7620
Participant_Condition
perimenopausal
7621
Participant_Age
41 to 60 years
7622
Participant_Sample-size
87
7623
Participant_Condition
postmenopausal
7624
Participant_Age
61 to 81 years