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Allogeneic marrow transplantation in patients with chronic myeloid leukemia in the chronic phase : a randomized trial of two irradiation regimens . A randomized trial was performed to compare two regimens of total body irradiation in patients with chronic myeloid leukemia treated by allogeneic marrow transplantation while in the chronic phase . All patients received cyclophosphamide 120 mg/kg followed by total body irradiation and marrow from HLA-identical siblings . Cyclosporine and methotrexate were used for prophylaxis against acute graft-versus-host disease . Fifty-seven patients were randomized to receive 2.0 Gy fractions of irradiation daily for 6 days and 59 were randomized to receive 2.25 Gy fractions daily for 7 days . The probabilities of relapse at 4 years were 0.25 for the 12.0 Gy group and 0.00 for the 15.75 Gy group ( P = .008 ) . The actuarial probabilities of survival and relapse-free survival at 4 years were 0.60 and 0.58 among the patients who received 12.0 Gy compared with 0.66 and 0.66 for those who received 15.75 Gy . The 4-year probabilities of transplant-related mortality were 0.24 and 0.34 respectively ( P = .13 ) while the probability of moderate to severe acute graft-versus-host disease was 0.33 for the 12.0 Gy group and 0.44 for the 15.75 Gy group ( P = .15 ) . The lower relapse probability in the patients receiving the higher dose of total body irradiation did not result in improved survival because mortality from causes other than relapse was increased .
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Intervention_Surgical
Allogeneic marrow transplantation
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Intervention_Physical
total body irradiation
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Intervention_Surgical
allogeneic marrow transplantation
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Intervention_Pharmacological
cyclophosphamide
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Intervention_Physical
total body irradiation and marrow from HLA-identical siblings
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Intervention_Pharmacological
Cyclosporine and methotrexate
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Intervention_Physical
irradiation
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Intervention_Physical
total body irradiation
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Outcome_Other
probabilities of relapse
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Outcome_Mortality
actuarial probabilities of survival and relapse-free survival
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Outcome_Mortality
probabilities of transplant-related mortality
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Outcome_Physical
probability of moderate to severe acute graft-versus-host disease
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Outcome_Other
relapse probability
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Outcome_Mortality
survival
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Participant_Condition
chronic myeloid leukemia in the chronic phase
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Participant_Condition
chronic myeloid leukemia treated by allogeneic marrow transplantation while in the chronic phase
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Participant_Sample-size
Fifty-seven