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document
NSAID Pretreatment Inhibits Prostaglandin Release in Femtosecond Laser-Assisted Cataract Surgery . PURPOSE To investigate whether short-term nonsteroidal anti-inflammatory drug ( NSAID ) pretreatment on the day of surgery inhibits prostaglandin release . Previous studies detected elevated prostaglandin levels after femtosecond laser treatment and identified them as a potential mediator for laser-induced miosis . METHODS Patients underwent either image-guided femtosecond laser cataract surgery or conventional cataract surgery ( n = 75 ) . Half of the eyes per group received topical NSAID treatment on the day of surgery . Aqueous humor was collected from all patients . ELISA measurements were performed to detect aqueous humor prostaglandin levels . RESULTS Femtosecond laser cataract surgery led to higher prostaglandin levels than conventional cataract surgery ( P = .007 ) . In both groups , NSAID pretreatment led to reduced prostaglandin release . In the femtosecond laser group , patients pretreated with NSAIDs had significantly lower prostaglandin values ( 65.3 ± 13.2 pg/mL ) than patients not pretreated with NSAIDs ( 294.4 ± 66.5 pg/mL ) ( P = .0009 ) . CONCLUSIONS The short-term NSAID treatment prevented prostaglandin release in patients treated with image-guided femtosecond laser . Therefore , it has potential to limit intraoperative laser-induced miosis .
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Intervention_Pharmacological
NSAID
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Intervention_Surgical
Femtosecond Laser-Assisted Cataract Surgery
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Intervention_Pharmacological
nonsteroidal anti-inflammatory drug ( NSAID
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Intervention_Surgical
femtosecond laser treatment
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Intervention_Surgical
image-guided femtosecond laser cataract surgery or conventional cataract surgery
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Intervention_Pharmacological
topical NSAID treatment
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Intervention_Surgical
Femtosecond laser cataract surgery
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Intervention_Control
conventional cataract surgery
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Intervention_Pharmacological
NSAID pretreatment
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Intervention_Pharmacological
pretreated with NSAIDs
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Intervention_Pharmacological
NSAIDs
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Outcome_Physical
Prostaglandin Release
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Outcome_Physical
prostaglandin release .
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Outcome_Physical
prostaglandin levels
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Outcome_Physical
aqueous humor prostaglandin levels .
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Outcome_Physical
prostaglandin levels
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Outcome_Physical
prostaglandin release
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Outcome_Physical
prostaglandin values
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Outcome_Physical
prevented prostaglandin release
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Participant_Condition
Cataract
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Participant_Condition
Patients underwent either image-guided femtosecond laser cataract surgery
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Participant_Condition
conventional cataract surgery
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Participant_Sample-size
( n = 75
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Participant_Sample-size
all patients
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Participant_Sample-size
femtosecond laser group
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Participant_Condition
patients treated with image-guided femtosecond laser