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Mechanisms of Sleep-Wake Cycle and Genetics of Sleep Disorders . A Review

Sleep is indispensable to replenish energy sources in the brain that are depleted during wakefulness. A variety of significant physiological changes occur in all body systems and organs during sleep as a result of functional alterations in the autonomic and somatic nervous systems. Inadequate sleep and sleep disorders have important adverse consequences on multiple systems with particular relevance to cardiovascular disease such as high BP, insulin resistance, systemic inflammation, visceral fat deposition and Parkinson’s disease.