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Investigation of alveolar stability in the rat lung using transthoracic endoscopy

Transthoracic endoscopy was used to investigate mechanical stability of subpleural alveoli during repeated recruitment manoeuvres and at different plateau pressures between these manoeuvres in healthy rats ventilated at ZEEP. Images of subpleural alveoli were continuously recorded and alveolar size was measured frame by frame. Preliminary results show that the size of subpleural alveoli is constant over a wide pressure range and that repeated recruitment manoeuvres do not lead to further enlargement of alveoli. Higher plateau pressures lead to slight enlargement of subpleural alveoli.