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Nickel cobalt and chromium sensitivity in patients with pompholyx (dyshidrotic eczema)

Sixteen patients with negative routine patch tests were challenged orally in a controlled trial with 2.5 mg nickel, I nig cobalt, and 2.5 nig chromium given as salts of the respective metals. All of the patients had symmetrical, vesicular hand dermatitis and in some cases also foot involvement. The dermatitis of two patients flared after challenge with cobalt; in two patients flare occurred following chromate ingestion.