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Alpha-particle incidence in small targets

A method for the direct measurement of the frequency distribution of α-particle incidence in targets of similar dimensions to cell nuclei is described. In addition to yielding the value of the mean dose in rads, these measurements enable the variation of dose in small targets to be expressed as percentages of cell nuclei receiving zero, single or multiple incidences in a stated time interval. The relevance of this ' particle incidence ' concept of dose is discussed in relation to carcinogenesis and illustrated by actual measurements in bones containing 239Pu.