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Free Radical Scavenging and Cytoprotective Activity of Salacia Euphlebia Merr

The present study reports the antioxidant activity of Salacia euphlebia stem extract. To understand the antioxidant activity of this plant, four compounds were isolated and elucidated as vitexin, 15α-hydroxyfriedelan-3-one, siphulitol and mangiferin. Mangiferin showed high free radical scavenging activity (EC50 1.10 ± 0.18 μg/mL) in comparison with quercetin (EC50 1.35 ± 0.02 μg/mL), while vitexin (IC50 37.6 ± 1.1 μg/mL) showed a good cytoprotective effect compared with quercetin (IC50 76.1 ± 1.0 μg/mL). This is the first report of the activities and bioactive compounds of S. euphlebia. These results may scientifically explain the folk and alternative-medicine use of this plant in longevity formulas.