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Alloantibodies other than anti-D in pregnant women.

Alloantibodies other than ant-D in two primigravidas have been reported. There was no history of exposure to risk factors. One of these primigravida developed anti-E and anti-c of IgM specificity and another developed anti-Jkb of IgG specificity. No evidence of hemolytic disease of the newborn was noted in both cases. From the family studies of both cases, the maternal alloantibodies seem to have been induced by the fetal red cell antigens. Although alloantibodies can occur in primigravidas, the incidence is very low. It seems unnecessary to do routine prenatal antibody screening in our population.