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Effect of Chronic Nicotine Treatment and its Withdrawal on the Vasopressinergic System in Rats

We have studied the effect of chronic nicotine treatment and its withdrawal on the hypothalamo‐neurohypophyseal Vasopressinergic system in male Sprague‐Dawley rats. They were subcutaneously infused with low and high doses of nicotine, free base (0.6 and 6.0 mg/kg/day, respectively) for 28 days, via Alzet osmotic pumps. The studies were carried out immediately after the period of infusion and 1, 7, 14 and 28 (the latter in high dose only) days later. Basal, high K+‐stimulated and total vasopressin release from the superfused neural lobes, the residual vasopressin content in the neural lobes, and hypothalamus and plasma vasopressin concentration were measured by radioimmunoassay.