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NHERF1 loss results in metabolic stress and increased susceptibility to cisplatin‐induced acute kidney injury

Acute kidney injury (AKI) is associated with a high mortality rate and develops in 30% of patients who receive cisplatin. The sodium hydrogen regulatory factor isoform 1 (NHERF1) is a scaffolding protein that anchors multiple membrane proteins, in renal proximal tubules. We have recently demonstrated that NHERF1 loss results in changes in mitochondrial protein abundance and function.