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Synthesis and Characterization of a Novel PAA Carrier for Apitoxin of Apis mellifera L.

The current study aimed to characterize a novel bee venom –loaded polyacrylic acid carrier intended for cancer therapy. Honey bee venom was collected by the electric shock method. Poly acrylic acid and venom-loaded polyacrylic acid were prepared using potassium peroxodisulfate as an initiator. Nanoformulation was achieved by emulsion-solvent diffusion. Characterization was achieved by FT-IR, 1H-NMR, TEM, DFED, and UV spectrophotometry. TEM showed that the resultant spherical nanoparticles were either dispersed or in a nodular form and their diameter was 17-210 nm. DFED showed that the resultant nanoparticles did not show crystalline edges. FTIR and 1H-NMR concluded that there was no marked interaction between drug and selected polymer except in the physical encapsulation process. UV spectrophotometry indicated a 95% uniformity of drug content in the resultant nanoparticles. The study concluded that the PAA carrier may be a promising suitable carrier for bee venom.