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Metabolo-volumetric parameters of 18F-FDG-PET can predict expression of EGFR and HIF 1alpha in uterine cervical cancer.

BACKGROUND
The aim of our study was to investigate possible relationships between 18F-FDG-PET parameters and clinically relevant histopathological findings in patients with cervical cancer (CC).


METHODS
Eighteen female patients (mean age 55.4 years) with histologically confirmed squamous cell CC were involved into the study. In all cases, 18F-FDG-PET CT was performed. Mean and maximum standardized uptake values (SUVmean and SUVmax), total lesion glycolysis (TLG) and metabolic tumor volume (MTV) were determined on PET-images. For every tumor the following specimen stainings were performed: epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), tumor suppressor protein p53, hypoxia-inducible factor (HIF)-1α, and histone 3. All stained specimens were digitalized and analyzed by using the ImageJ software 1.48v. Spearman's correlation coefficient (p) was used to analyze associations between investigated parameters. p-values < 0.05 were taken to indicate statistical significance.


RESULTS
TLG and MTV correlated well with expression of EGFR (p= 0.601, P= 0.008 and p= 0.586, P= 0.011, respectively). SUVmedian correlated inversely with expression of HIF 1alpha (p=-0.509, P= 0.031). SUVmean tended to correlate with expression of EGFR and HIF 1alpha. None of the PET parameters correlated with expression of Histone 3, p53 and VEGF.


CONCLUSION
TLG and MTV can reflect expression of EGFR and SUVmedian correlated significantly with expression of HIF-1α. None of the PET parameters can predict expression of Histone 3, p53 and VEGF.