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[B lymphocyte abnormalities in connective tissue disorders].

In addition to the precursors of Ab-secreting cells, B lymphocytes have more essential functions in regulating immune responses than had previously been appreciated. B cell functions include antigen-presenting cells, production of various cytokines, and differentiation of T effector cells. Abnormalities of these B cell functions could contribute to the induction or development of autoimmunity in systemic autoimmune disorders. In this regard, the importance of B cells in systemic autoimmunity and disease expression has been emphasized; therefore, various B cell targeting therapies will be applied to connective tissue disorders more intensively.