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Increased activity of cathepsin B in fibroblasts isolated from primary melanoma in comparison to fibroblasts from normal skin

Abstract: We determined activity of cathepsin B in early‐passage fibroblasts isolated from primary melanoma and in fibroblasts from normal skin. Our results show an up to 5‐fold increase in activity of cathepsin B in the tumor‐derived fibroblasts in comparison to the fibroblasts from normal skin. We conclude that fibroblasts isolated from melanoma tissue are altered with regard to their specific activity of cathepsin B and preserve this elevated activity in early‐passage cell culture. The data support the idea that stromal cells are not passive elements of the peritumoral environment but actively participate in the production of proteolytic enzymes.