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Prognostic markers in node‐negative breast cancer: A prospective study

Despite years of research, it is still unclear which women with node‐negative (N–) breast cancer will need adjuvant chemotherapy and which women are being treated unnecessarily. Our goal was to determine which factors best predicted disease free survival (DFS) or cancer‐specific overall survival (OS) and, therefore, select the correct patients for treatment. A total of 11 parameters were measured: estrogen receptor (ER), progesterone receptor (PR), age, race, ploidy status, %G0/G1 (% non‐DNA synthesis), %S (% S‐phase), cathepsin D status, size, stage, and histologic grade.