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Role of Exosomes in Photodynamic Anticancer Therapy.

Photodynamic therapy (PDT) is a promising alternative treatment for malignancies basing on photochemical reaction induced by photosensitizers (PS) under light irradiation. Recent studies show that PDT caused abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting extensive attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.