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The effect of mode of agitation and type of plastic bag on storage characteristics and in vivo kinetics of platelet concentrates

We studied the characteristics of platelet concentrates stored for 5 days at 22°C. Platelets were prepared in three plastic bags (PL 732, PL 1240, and CLX) and stored on one of four platelet agitators, 1‐ or 6‐rpm elliptical and 2‐ or 6‐rpm circular rotators. A total of 76 studies were divided among 12 groups, each group being composed of a different storage bagrotator combination. In vivo recovery and survival were calculated using Indium‐111 oxine‐labeled platelets injected into autologous volunteers. Platelet recovery was assessed at 2 hours postinjection or as the y‐intercept of the multiple‐hit model survival curve. Survival was calculated using linear, exponential, and multiple‐hit computer models. Linear T 1/2 also was calculated as an index of platelet survival.