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Endocrine Complications in Children and Adolescents with Cancer

For all cancers the combined 5-year survival rate has increased dramatically over the last 20 years, reaching figures between 70% and 88% in Europe and the United States'. These figures reflect the progress made in paediatric oncology in the last few decades. More than half of the survivors will have a chronic medical problem as a sequela of anti-tumoural therapy. Endocrine and metabolic problems occur frequently. They include growth impairment, growth hormone deficiency, increased risk of cardiovascular risk factors, osteopenia, radiation-induced disorders of the thyroid and parathyroid, gonadal dysfunction, adrenocortical insufficiency, diabetes mellitus, diabetes insipidus, and the syndrome of inappropriate secretion of antidiuretic hormone.