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Activity of Voriconazole Against Corneal Isolates of Scedosporium apiospermum

Purpose. To determine the in vitro antifungal activity of voriconazole, a new triazole, compared with other polyene and imidazole antifungal agents against corneal isolates of Scedosporium apiospermum. Methods. Macro-broth dilution susceptibility testing was performed on five isolates of S. apiospermum obtained from patients with keratomycosis to determine the minimal inhibitory concentrations (MICs) for amphotericin B, natamycin, ketoconazole, itraconazole, and voriconazole. The use of oral voriconazole in the management of a patient with posttraumatic S. apiospermum keratitis is described. Results. S. apiospermum is generally resistant to commonly used topical ophthalmic antifungal agents. The MIC of voriconazole was 0.5 &mgr;g/mL, a concentration lower than that of other imidazoles. Conclusion. Voriconazole has promising activity against S. apiospermum and may prove useful in the management of fungal keratitis.