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Non-invasive intracranial pressure monitoring and neurovascular coupling assessment in the context of brain injury (Conference Presentation)

Cerebral blood flow regulation is impaired in many diseases and treatment based on optimizing blood flow regulation is promising for patient outcome, but may require intracranial pressure (ICP) to be known. We have recently developed a non-invasive alternative based on a combination of near-infrared spectroscopy and diffuse correlation spectroscopy. This talk will summarize the optical imaging setup, experimental procedures, and data analysis. Data from non-human primates as well as clinical data from pediatric critical care patients will be presented. We will further present data on neurovascular coupling during ICP changes, suggesting a link between blood flow regulation and neuronal activity.