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[Study of SOD and PON-1 expression in type 2 diabetes mellitus nephropathy and its clinical significance].

AIM
To investigate the clinical value of superoxide dismutase (SOD) and paraoxonase-1 (PON-1) in type 2 diabetes mellitus (T₂DM) nephropathy.


METHODS
80 cases of T₂DM patients were divided into T₂DM nephropathy group (ND group, 40 cases), and non-T₂DM nephropathy group (non-ND group, 40 cases), the SOD, PON-1 levels and biochemical levels of the two group were measured, the HOMA-IR was recorded.


RESULTS
The SOD and PON-1 levels of the ND group were lower than the non-ND group, compared the difference was significant (P < 0.05). The FINS, FINS levels and HOMA-IR of the ND group were higher than the non-ND group, compared the difference was significant (P < 0.05). The FBG, PBG2h and HbAlc levels were no significantly different (P > 0.05). Serum SOD, PON-1 levels and HOMA-IR were significantly negatively correlated (r = -0.287, -0.509; P = 0.006, 0.000), serum SOD level and PON-1 level was no significantly correlated (P > 0.05).


CONCLUSION
The serum SOD and PON-1 involve in the development of T₂DM nephropathy. Combined detection of serum SOD and PON-1 have important clinical significance for early diagnosis, prevention, treatment and prognosis of T₂DM nephropathy.