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Anti‐Inflammatory and Analgesic Activities of Newly Synthesized Chiral Peptide Derivatives Using (3‐Benzoyl‐ 4,5‐dioxo‐2‐phenyl‐pyrrolidin‐1‐yl)acetic Acid Ethylester as Starting Material

A series of heterocyclic derivatives was synthesized using (3‐benzoyl‐4,5‐dioxo‐2‐phenyl‐pyrrolidin‐1‐yl)acetic acid ethyl ester 1 as starting material. Treatment of 1 with 1 N NaOH or hydrazine hydrate afford the corresponding acid 2 and acid hydrazides 4 and 5, which were reacted with several reagents to produce some new peptido hetero‐organic derivatives 6–12. The pharmacological screening showed that many of these newly synthesized compounds have good anti‐inflammatory and analgesic activities comparable to diclofenac potassium and valdecoxib as reference drugs.