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Prenatal Histological, Cellular and Molecular Anomalies in Down Syndrome Lung

Down Syndrome (DS), from trisomy 21 (T21), is the most common human chromosomal anomaly in the United States. Although DS can affect many organ systems, lung and heart disease are the leading causes of death. An abundance of existing data suggests lung abnormalities originate postnatally in DS. However, a single report of branching insufficiency in DS has inferred a potential prenatal origin.