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The cornea and systemic disease

The cornea is involved in many systemic disorders. However, the management of those corneal changes associated with the connective tissue diseases has altered considerably as a result of a better understanding of the etiology of these disorders. The clinical features that differentiate one etiology from another are now becoming apparent and many of these changes can be supported by laboratory investigations. The relationship between these conditions and abnormalities of the tears are still poorly understood and until this relationship is clearer, there will be no great strides forward in therapy.