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Cooperative disordering of single‐stranded polynucleotides through copper crosslinking

The thermal transitions of single‐stranded polynucleotides are noncooperative. In contrast, Cu(II) cooperatively disorders the single‐stranded helical structures of poly(A) and poly(C), as demonstrated by ORD and UV spectral changes as a function of the Cu2+ activity, and by a dramatic chain‐length dependence of the spectral changes. Equilibrium dialysis binding studies indicate that the cooperative disordering is paralleled by a somewhat less cooperative binding process.