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Therapeutic Hypothermia as a Neuroprotectant for Post ‘ Out-of-Hospital ’ Cardiac Arrest : a Meta-Analysis

Cardiac arrest (CA) is the most relevant cause of global cerebral ischaemia (GCI). With annually 30,000 people in the UK suffering an out-of-hospital CA, only 18% survive (Kendal et al, 2012). Animal and clinical studies suggest mild to moderate resuscitative hypothermia (3035 o C) might improve mortality and morbidity. A meta-analysis was carried out to assess mildmoderate hypothermia post CA, outcomes of interest being neurological outcome and survival.