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[The inhibitory effects of glucocorticoid on the proliferation and steroidogenesis of the adrenal cortex at the adrenal level (author's transl)].

There is much evidence to suggest that cell proliferation and steroidogenesis of the adrenal cortex are regulated by adrenocorticotropin (ACTH). Recently, direct inhibitory effects of glucocorticoid on cell proliferation and steroidogenesis of the adrenocortical cells has also been suggested. However, contradictory data have been reported, and the possible physiological significance of such direct action of glucocorticoid remains to be established. A monolayer culture of mouse adrenal tumor cell line Y-1 was used to investigate the effects of glucocorticoid on cell replication, DNA synthesis, steroidogenesis and ACTH receptors of adrenocortical cells in an in vitro condition. In an in vivo human study, a rapid ACTH test was repeated twice on each of 5 healthy female volunteers at an interval of 2 weeks, with 2 and 12 mg of dexamethasone administered from 11-12 PM the previous night. The results obtained were as follows: 1) Corticosterone at a concentration of 5.0, 50 μg/ml significantly inhibited cell re-