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Effects of glucagon on resting and exercise haemodynamics in patients with coronary heart disease.

The haemodynamic effects of glucagon administered into the pulmonary artery in a single dose of 15, 30, or 45 pg/kg were studied in 9 patients who had coronary heart disease. Glucagon did not significantly affect heart rate, cardiac index, left ventricular end-diastolic pressure, or mean brachial artery pressure either at rest or during mild supine leg exercise. The abnormal increase in left ventricular end-diastolic pressure seen in some patients during exercise was not prevented by glucagon administration. A second group ofpatients underwent two identical periods of exercise separated by a xo-minute period of rest. The changes in the haemodynamic parameters measured were reproducible between exercise periods.