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Brunner's Gland Hamartoma: Is It Just a Morphologic Curiosity?

Brunner's gland hamartoma (BGH), characterized by benign proliferation of the Brunner's glands, was first described by Cruveilhier in 1835. Since then, case reports have been sporadic, and virtually all were clinicopathologic studies.2-13 Many patients with BGH were asymptomatic,13 while others presented with bleeding,3,6-8,12,13 duodenal obstruction, intussusception, or obstruction of the common bile duct or pancreatic duct. These patients were classified as having hamartomas because the proliferation of the Brunner's gland was accompanied with other components, such as smooth muscle bundles and Paneth cells, all of which are native components of this anatomic location.14,15 BGHs have not been studied for their possible dynamic aspect either as a target organ or as the primary site of functional alteration, and they remain a clinicopathologic curiosity.