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Accelerated Closure of Biopsy-Type Wounds by Mechanical Stimulation

OBJECTIVE: To determine whether a device designed to provide low-intensity, low-frequency mechanical stimulation improves healing time of acute wounds. DESIGN: Repeated measures using mechanical stimulation on one side of a rat and sham stimulation on the contralateral side. SETTING: Academic animal facility. PARTICIPANTS: Six male Sprague-Dawley rats, approximately 400 g. INTERVENTION: Mechanical stimulation of 4-mm biopsy wounds in rats was produced through the use of permanent magnets cyclically attracted and repelled by activation of an electromagnet by a square wave generator at a frequency of 1 Hz and a force equivalent to 64 mm Hg pressure. MAIN OUTCOME MEASURE: Days to complete closure of 4-mm biopsy punch wounds. MAIN RESULTS: This form of stimulation reduced time to close the biopsy wounds by nearly 50%. Mechanically stimulated wounds closed in 3.8 ± 1.6 days (mean ± SD) compared with 6.8 ± 1.9 days for sham-stimulated wounds (P = .0002). CONCLUSION: Production of a mechanical stimulation device with a miniaturized controller and power source and trials on humans are needed to determine the efficacy and potential cost savings of such a device in the management of wounds.