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Impact of elderly patient laparoscope colorectal cancer radical operation for body stress and visceral protein

Objective:To compare the alterations of operative stress response-reactive protein(CRP),interleukin-6(IL-6),IL-10 and visceral proteins after laparoscopic-assisted and open resection of colorectal carcinoma in advanced age patients.Methods:According to the patients' choice of the operation,laparoscopic-assisted(n=20) and open(n=21) resection of colorectal carcinoma were performed.IL-6,IL-10,CRP and visceral protein which includes Prealbumin(PRE),Transferrin(TRF) and Retinal-binding protein(RBP) were assayed preoperatively and at the 6h,1st,2nd and 3rd day postoperatively.Results:CRP levels in both groups increased at the 1st,2nd and 3rd day postoperatively compared to the preoperative period(P0.01)and peaked at the 2nd day postoperatively,the responses in the laparoscopic group significantly less than those in the open group(P0.01).The plasma levels of IL-6 and IL-10 were significantly increased after the operation in both groups,which was significantly lower in the laparoscopic group.The levels of PRE,TRF and RbP significantly decreased after operation in both groups(P0.01),but there are not differences at the 1st and 2nd day(P0.05),all the levels of the four proteins in the laparoscopic group were significantly higher than those in the open group at the 3rd day postoperatively(P0.01).Conclusions:Laparoscopic-assisted resection of colorectal carcinoma results in less prominent stress response compared to open surgery in advanced age patient,These benefit the restoration of visceral proteins.It's a strong support for the practice of minimal invasive surgery.