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Effect of estrogen on the phospholipid metabolism of rat bone.

The influence of estrogen on phospholipid synthesis of bone was investigated using both in vitro and in vivo systems. Rats were injected with 17β–estradiol benzoate im and 32P orthophosphate sc. The metaphyseal and diaphyseal portions of the bone were separated, and the total phospholipid content and the incorporation of 32P orthophosphate into the phosphatides of bone were determined. When estrogen was administered to ovariectomized rats, the phospholipid content of diaphyseal bone increased. The incorporation of 32P into phospholipid was increased in the metaphyseal and diaphyseal bones of estrogen treated animals. The effect of estrogen on the incorporation of 32P into phosphatides was observed primarily in phosphatidyl choline and sphingomyelin. These results suggest that estrogen enhances the synthesis of some phospholipids of bone and that this may be related to the inhibition of resorption which is known to occur. (Endocrinology 92: 961, 1973)