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Eurotium Cristatum reduces obesity by alleviating gut microbiota dysbiosis and modulating lipid and energy metabolism.

BACKGROUND
Fuzhuan brick tea (FBT) has been shown to prevent obesity, but little is known about the effect of Eurotium Cristatum (E. Cristatum), a critical fungus from FBT. This study examined the effects of live E. Cristatum on lipid metabolism and gut microbiota composition in high-fat (HF) diet-induced obese mice.


RESULTS
Male HF diet-fed mice were treated with E. Cristatum for 12 weeks. The results showed that E. Cristatum administration caused strong inhibition against HF-induced body weight gain, dyslipidemia and liver oxidative stress damage. Additionally, Firmicutes and Bacteroidetes in phylum level and six types bacterial including SCFAs producing bacteria in genus level were found to be significantly changed in E. Cristatum treated mice as compared to HF fed mice. As expected, E. Cristatum could increase total SCFAs levels in feces. Interestingly, E. Cristatum markedly increased the proportion of Akkermansia to defense obesity. Functional prediction analysis indicated that E. Cristatum changed the lipid and energy metabolism. Furthermore, E. Cristatum ingestion can modulate hepatic FAS, ACC, SREBP-1 and adipose UCP-1 expression.


CONCLUSION
Conclusively, these findings suggest that E. Cristatum can prevent the HF-induced lipid accumulation and other complications by modulating gut microbiota, lipid and energy metabolism. This article is protected by copyright. All rights reserved.