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Identification of anti-hepatic fibrosis components in Periplaneta Americana based on spectrum-effect relationship and chemical component separation.

Periplaneta Americana (PA) is a traditional medicine used for hepatic disease such as hepatic fibrosis in China. However, the relationship between the corresponding therapeutic effect and the chemical composition is still unclear. In this study, spectrum-effect relationship and chemical component separation was used to discovery potential anti-hepatic fibrosis components of PA. The fingerprints of 10 batches sample were established by HPLC and anti-hepatic fibrosis effect was determined using HSC-T6 cells. The spectrum-effect relationship between common peaks and efficacy values was established using partial least squares analysis. Partial peaks in the fingerprints were identified, including X4 (9,12-heptadecanedenoic acid glyceride), X5 (nonadecanoic acid methyl ester), X6 (glyceryl oleate), X7 (13,16,19-eicosatrienoic acid), X9 (linoleic acid), X10 (9,12,15-octadecatrienoic acid glyceride), X12 (hexadecanoic acid), X13 (oleic acid) and X14 (octadecanoic acid), and their anti-hepatic fibrosis activity were tested to verify the results of spectrum-effect relationships. The results showed that X4 , X6 , X7 and X10 were the active ingredients of PA. This work successfully identified the partial anti-hepatic fibrosis components of PA, which can be used to explain the material basis for the PA anti-hepatic fibrosis effect.