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Noninvasive assessment of fetal central nervous system insult: Potential application to prenatal diagnosis

We have developed novel methods for isolating fetal central nervous system (CNS)‐derived extracellular vesicles (FCEs) from maternal plasma as a non‐invasive platform for testing aspects of fetal neurodevelopment in early pregnancy. We investigate the hypothesis that levels of defined sets of functional proteins in FCEs can be used to detect abnormalities in fetal neuronal and glial proliferation, differentiation, and survival.