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Antibacterial efficacy of Allium sativum (garlic) and chitosan incorporated into two root canal sealers against Enterococcus faecalis: comparative study

Aim This study evaluated the antibacterial activity of mineral trioxide aggregate (MTA) fillapex and Gutta-flow 2 sealers in the commercial unmodified form and two modified forms with chitosan and Allium sativum against Enterococcus faecalis strain (ATCC 2912). Materials and Methods The material tested were MTA fillapex and Gutta-flow 2 sealers in the commercial unmodified form and two modified forms with chitosan and A. sativum at concentrations 5, 10, and 20%. Agar diffusion test was used to evaluate the zone of inhibition of freshly mixed unmodified and modified materials against E. faecalis strain (ATCC 2912). Results The incorporation of A. sativum and chitosan into MTA fillapex sealer can significantly enhance its antibacterial activity against E. faecalis at all concentrations. However, the addition of A. sativum and chitosan to Gutta-flow 2 sealer exhibited no antibacterial effect except for Gutta-flow 2 that modified with 20% chitosan. Conclusion A. sativum and chitosan incorporated into MTA fillapex sealer can significantly improve its antibacterial efficacy of against E. faecalis. Also the incorporation of 20% of chitosan can enhance the antibacterial activity of Gutta-flow 2 sealer.