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Letter: mechanistic target of rapamycin inhibitors—do they impact on recurrence of hepatocellular carcinoma after liver transplantation? Authors' reply

© 2019 John Wiley & Sons Ltd pre‐LT was the only independent factor significantly associated with HCC recurrence after LT.5 In conclusion, the literature suggests that mTORs might ben‐ efit patients transplanted for HCC, particularly those with HCC within Milan criteria pre‐transplant. However, as Grigg et al1 recognized, larger well‐designed studies with long follow‐up are needed for final conclusions regarding the impact of several pre‐ operative (eg microvascular invasion and HCC differentiation) and post‐operative (eg mTORs trough levels) factors on HCC re‐ currence after LT.