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Isolation of bioactive components from Corallocarpus epigaeus tuber and inhibitory potential against various molecular forms of acetylcholinesterase

In human, acetylcholinesterase (AChE) is involved in cholinergic neurotransmission. AChE exhibits as different globular form such as G4 (tetramer), G2 (dimer) and G1 (monomer). For the most part of the adult brain G4 forms is present. Nevertheless, under dementia such as Alzheimer’s disease (AD) conditions, the ratio between G1 and G4 form is increased which is involved in disease progression. Inhibition of AChE is considered important therapeutic intervention to overcome the AD. Corallocarpus epigaeus comes under the family of Cucurbitacea has known for the biological properties such as anti‐snake venom, analgesic, anthelminthic properties and antidiabetic activity. Identifying natural compounds with AChE inhibition is considered important for AD treatment. In the present study, bioactive fraction extracted from tuber of C. epigaeus was investigated for its inhibition against different molecular forms of AChE in in vitro.