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Doxycycline in bronchitis: results of a multicentre study.

SummaryDuring the winter of 1976/1977, a multicentre general practice trial in 6 European countries was carried out in 471 patients with bronchitis who required treatment with an antibiotic: 36% had acute bronchitis, 18% had acute exacerbation of chronic bronchitis, 34 % had chronic bronchitis, and the type was not specified in 12 % of the patients. All patients were treated with doxycycline (200 mg on the first day, reduced to 100 mg per day in most cases from Day 2 onwards) for 10 days. Parameters such as temperature, cough severity, sputum production and relative difficulty in raising sputum were measured. Clinical evaluations were made in all patients and pulmonary function studies were monitored in a selected group. Overall, 89 % of the patients showed an adequate response, those with acute bronchitis showing the best response (95%,). Side-effects, which were usually mild and self-limiting, were reported in 8'% of patients.