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The value and significance of nucleolar organizer region (AgNOR) proteins in ulcerative colitis and adenocarcinomas of the large bowel

In the large bowel, the silver-stained nuclear organizer region (AgNOR) method has been extensively employed to study dysplastic and carcinomatous lesions”, whereas, to our knowledge, no studies on AgNORs in ulcerative colitis have been performed. The aim of this study was to assess and compare the proliferative activity in long-standing inactive and active ulcerative colitis and in colonic adenocarcinomas by means of the AgNOR technique.