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Functional Analysis of the MacroH2A Histone Variant During Zebrafish (Danio rerio) Development

In the nucleus, DNA is associated to different proteins, forming a highly dynamic nucleoprotein complex termed chromatin. Assembly of DNA into nucleosomes causes a massive repression of transcription, which can be reversed by different epigenetic mechanisms, such as post‐translational modification of histones and incorporation of histone variants. The variant of the canonical histone H2A, macroH2A (mH2A), possesses a large non‐DNA binding C‐terminal domain termed "non‐histone region" (NHR), which is thought to inhibit two processes that are essential for chromatin activation, histone acetylation and nucleosome remodeling.