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THE INFLUENCE OF OXYTOCIN ON PRO- AND ANTIOXIDANT STATE AT DIABETIC ANIMALS

The aim of the investigation was to study the influence of course central and peripheral oxytocinintroduction on the state of pro- and antioxidant systems in healthy and diabetic animals. It isfound out that oxytocin introduction promotes the decrease of the activity of free radical oxidation process in erythrocytes in healthy animals. In diabetic animals, which were administered oxytocin by, the significant decrease of the content of primary, secondary and definitive products of peroxide lipid acidification has been observed. It has been registered on the background of the increase of catalase and glutationreductase activities and the increase of α-tocopherol content. These changes of antioxidant components activity of erythrocytes defense were actually higher in the process of central introduction of neuropeptide. The results observed show the antioxidant activity of oxytocin that may be realized through the intensification of antioxidant defense processes