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The effect of initiation of antiretroviral therapy on monocyte, endothelial and platelet function in HIV‐1 infection

Monocyte activation, endothelial dysfunction and platelet activation all potentially contribute to the increased risk of cardiovascular disease (CVD) reported in those with HIV‐1 infection. To date, no study has examined how initiation of antiretroviral therapy (ART) affects markers of all three processes. We aimed to compare markers of monocyte, endothelial and platelet function between untreated HIV‐positive subjects and HIV‐negative controls and to examine the early effects of ART initiation on these markers.