{'fraction_non_alphanumeric': 0.02681992337164751, 'fraction_numerical': 0.01954022988505747, 'mean_word_length': 5.261390887290168, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
Sotos ' syndrome . Neuroblastoma in a patient with

Sotos' syndrome, or cerebral gigantism, is a disorder of growth regulation. Tumours have occasionally been reported in children with Sotos' syndrome, but it is uncertain whether this is a coincidence, or whether it is aetiologicaily related to the underlying disorder of growth. We report a 15 month old child with a paraspinal neuroblastoma and Sotos' syndrome and suggest that children with this condition may be at higher risk for developing tumours than the general population. Sotos' syndrome was first described in 1964 in five unrelated children who had large body size for age with advanced bone age and similar facial features (large jaw, large forehead with frontal bossing, temporal hair recession, hypertelorism, and downward slanting palpebral fissures). 1 Subsequent reports have confirmed the characteristic phenotype, and added to it other consistent features, such as developmental delay, clumsiness and other neurological abnormalities, enlarged ventricles on x ray, and early eruption of deciduous teeth.2A The cause of this primordial overgrowth syndrome is not known; serum growth hormone and somatomedin C levels are normal, and no histological or laboratory evidence of pituitary or hypothalamic dysfunction has been found.5 6 Most cases of Sotos' syndrome are sporadic, although other genetic patterns have appeared in isolated families. The relationship between Sotos' Division of Genetics, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA. M A Nance, S A Berry Division of Oncology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA. J P Neglia Division of Pediatric Neurology, Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA. D Talwar Correspondence to Dr Nance, Division of Genetics, Department of Pediatrics, Box 391 UMHC, 420 Delaware St SE, Minneapolis, MN 55455, USA. Received for publication 6 June 1989. Revised version accepted for publication 7 August 1989. syndrome and neoplasia is uncertain; however, a disproportionate number of patients reported with this diagnosis have also had malignancies. Case report A 15 month old child presented to the Variety Club Children's Hospital at the University of Minnesota with a one month history of loss of developmental milestones and the development of abnormal eye and limb movements. She was born with a birth weight of 3892 g at 36 weeks of gestation to a 27 year old, G3P3 mother and a 41 year old father. Her growth chart is illustrated in fig 1. Her first teeth erupted at four