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One-Pot Synthesis of Amino Alcohols from Styrenes

A two-step one-pot procedure for the synthesis of amino alcohols mediated by 1,3-dibromo-5,5-dimethylhydantoin (DBH) in aqueous acetone solution was developed. Styrene derivatives were treated with DBH at room temperature for 0.5 ～ 2.0 h followed by the addition of amine, affording the corresponding amino alcohols in 64% ～ 88% yields. Tulobuterol, a widely used β 2-adrenergic agonist, was prepared by this protocol in gram scale with the yield of 77%.