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A Safe Automatic Driving Method for a Continuous Flow Ventricular Assist Device Based on Motor Current Pulsatility:In Vitro Evaluation

We previously reported that detection of two specific points (the t-point and the s-point) in the relationship between pump speed and Motor Current Amplitude index (ICA) indicates the safe driving range for a continuous-flow ventricular assist device (CFVAD). During the first stage of the present experiment, the characteristic curves relating pump speed and ICA were determined by varying preload (left atrial pressure: −6 to 30 mm Hg), afterload (total circuit resistance: 890 to 3,180 dyne · sec · cm−5), and contractility of the left ventricle (total circuit flow: 0.5 to 2.1 L/min). These data showed that an ICA value of 0.18 was always located between the t- and s-points. During the second stage of the experiment, we developed an automatic driving program to control pump speed by maintaining ICA at 0.18. This program was able to drive the CFVAD, without exhibiting regurgitant flow or sucking, under various driving conditions in the mock circulation. Pump speed stabilized within 1 minute after varying the drive conditions. This sensorless method of driving the CFVAD by using a target ICA proved feasible and effective for safe automatic control, within our mock circulation.