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Stereotactic Body Radiotherapy Provides Excellent Long-Term Local Control of Very Few Lung Metastases.

AIM
To evaluate treatment outcomes after stereotactic body radiotherapy (SBRT) for a limited number of lung metastases mainly focusing on local control.


PATIENTS AND METHODS
Forty-six patients receiving SBRT for 1-3 lung metastases were retrospectively evaluated. Local control, freedom from distant progression and overall survival were evaluated in the entire series. In addition, nine factors (gender, age, performance status, interval between cancer diagnosis and SBRT, primary tumor type, other metastases, main site and number of lesions, irradiated volume, SBRT dose) were evaluated for local control.


RESULTS
Local control rates at 1, 2 and 3 years were 93%, 93% and 78%, respectively. Rates of freedom from distant progression were 57%, 38% and 29%, respectively, and overall survival rates were 66%, 56% and 36%, respectively. Only one patient (2%) experienced radiation-induced pneumonitis.


CONCLUSION
SBRT administered for very few lung metastases resulted in excellent long-term local control rates and was associated with very little toxicity.