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Investigation on Interaction of L-Methionine Dipeptide with ct-DNA by Ultraviolet Spectroscopy

In this article, L-methionine peptides were synthesized with the assistance of phosphorus oxychloride. L-methionine dipeptide was purified by HPLC and characterized by the means of 1 H-NMR, 13 C-NMR and ESI-MS. The interaction of L-Methionine dipeptide with ct-DNA was studied by ultraviolet spectra. The results showed that L-Methionine dipeptide could interact with phosphorous groups of ct-DNA. The influences of interaction time, ionic strength, and phosphate anion on the interaction between L-methionine dipeptide and ct-DNA were also investigated.