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Correlation between MTHFR gene polymorphism and homocysteine levels for prognosis in patients with pregnancy-induced hypertension.

OBJECTIVE
This research was designed to probe into the correlation between MTHFR gene polymorphisms and homocysteine levels in regard to the prognosis of pregnancy-induced hypertension.


METHODS
A total of 180 patients with pregnancy-induced hypertension who were admitted in the gynecology and obstetrics department of our hospital were collected as the observation group, and 180 normal pregnant women were selected as the control group. The homocysteine (Hcy) level, polymorphism expression of methylenetetrahydrofolate reductase (MTHFR) gene C677T locus and A1298C locus and the correlation between the different gene loci, Hcy level and pregnancy outcome were observed.


RESULTS
The Hcy level in the observation group was 18.1±6.2 (100 mmol/L) which was higher than that in the control group (8.6±3.9 mmol/L) (P<0.001). The C677T polymorphism of the MTHFR gene, and the proportion of CC in the observation group was lower than that in the control group, while that of CT and TT in the observation group was significantly higher (P<0.001). The T allele in the observation group was higher than that in the control group, while the C allele was lower than that in the control group (P<0.001). Hcy of TT type in pregnancy-induced hypertension group was higher than that in CC and CT groups (P<0.05). The incidence of adverse pregnancy outcomes in pregnancy-induced hypertension patients was obviously higher than that in normal control group (P<0.01). The incidence of TT type adverse pregnancy outcomes in MTHFR gene C677T polymorphism in patients with gestational hypertension was significantly higher than that in CC and TC groups (P<0.01).


CONCLUSION
The Hcy level in pregnancy-induced hypertension patients and the proportion of CT and TT in the MTHFR gene C677T locus rose; having the TT-type increased the incidence of abnormal pregnancy, which may be related to the increase of Hcy level.