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Pearls for optimizing biomedical manuscripts.

Publication in biomedical research is essential for dissemination of relevant information and advances in science and medicine. The main currency for biomedical publications is the manuscript, which can be of various types, including but not limited to original studies, reviews, and case series. Biomedical writing for purposes of a manuscript is an art which builds on early linguistic and scholastic experiences and is honed throughout one’s education, professional exposure, and training. Successful biomedical writing encompasses many considerations and steps, and along which various challenges exist that can impact an individual or group’s ability to effectively conceptualize, develop, and submit a manuscript. Such challenges include limited research time, unfamiliarity with and expanding journal (or other receiving body) requirements, language barriers, insufficient biostatistical expertise, and others; despite these and other rooted and emerging challenges, there are well-established principles by which biomedical writing can be uniformly and successfully undertaken and completed. In an effort to help investigators and authors allow their manuscripts to reach their full potential, here we provide pearls for optimizing both basic and clinical hepatology manuscripts, and by extension, other biomedical and scientific works. These pearls represent a synopsis of the requisite tools to prepare, submit, and successfully publish original, review, and other manuscript types. INITIAL CONSIDERATIONS