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Shingles vaccination reduces risk of Parkinson's disease

Background: Shingles vaccination protects against Alzheimer disease (AD), which is related to herpes virus infection. In the current analysis we attempted to determine if herpes zoster vaccination might reduce the risk of Parkinson Disease. Methods: Data on PD prevalence by US state is from Mantri et al, Table 1. They identified 27,538,023 Medicare beneficiaries that met inclusion criteria, of whom 392,214 had a PD diagnosis in 2014. Data on Shingles vaccination among adults aged 60 and over, United States, 2018 is from Terlizzi and Black, Figure 4. The NHIS data from 2008 to 2018 were used for this investigation. The NHIS is a household survey of the civilian, non-institutionalized U.S. population that is conducted nationally. It is continually carried out by the National Center for Health Statistics during the entire year (NCHS). Although follow-ups to completed interviews may be made over the phone, interviews are conducted in respondents' homes. Results: States with the most PD (lowest age adjusted prevalence ranks) had the lowest proportion of adults aged 60 and over who had ever received a shingles vaccine. Increased vaccination proportion led to significantly reduced female PD prevalence. Increased proportion of Medicare-Medicaid dual eligibility and increased health care spending were associated with diminished proportion of adults who had ever received a shingles vaccine. Conclusion: Shingles vaccination is a wise, cost-effective public health measure that may reduce PD and AD prevalence.