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Receptors for the liver synthesized growth factors IGF‐1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications

Purpose:  Uveal melanoma disseminates preferentially to the liver. The mechanism for this homing is largely unknown, but growth factors synthesized in the liver may be involved. The present study was undertaken to investigate the possible relationship between cell surface receptors for two such growth factors: the c‐Met proto‐oncogene, which constitutes the receptor for hepatocyte growth factor/scatter factor (HGF/SF), and the insulin‐like growth factor 1 receptor (IGF‐1R). Their role as a prognostic factor was also clarified.