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CD56−CD16+ NK cells from HIV‐infected individuals negatively regulate IFN‐γ production by autologous CD8+ T cells

The percentage of human CD56−CD16+ NK cells increases during chronic infection with human HIV; however, the biologic role of CD56−CD16+ NK cells in HIV infection is unclear. Our results demonstrate that the percentage of CD56−CD16+ NK cells producing IL‐10 and TGF‐β was higher than CD56dimCD16+ NK cells. CD56−CD16+ NK cells could inhibit IFN‐γ production by autologous CD8+ T cells, and this inhibition could be partially reversed by anti‐IL‐10, anti‐TGF‐β, or anti‐PD‐L1 mAbs. CD56−CD16+ NK cells are potential targets for the development of novel immune therapies against HIV infection.