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Bone marrow necrosis preceding acute lymphoblastic leukemia in childhood

Two patients who presented with bone marrow necrosis and eventually developed acute lymphocytic leukemia are reported, and similar cases in the literature are reviewed. Both patients responded to chemotherapy. Several possible mechanisms are discussed. Bone marrow necrosis appears to be another condition preceding acute lymphocytic leukemia in children. Cancer 52:2162‐2164, 1983.