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Chronic electrical stimulation of the ventral lateral periaqueductal grey (vlPAG) evokes a persistent and substantial hypotensive response in spontaneously hypertensive (SH) but not normotensive rats

Deep brain stimulation of the vlPAG is used for the clinical treatment of chronic neuropathic pain in man. It also produces sustained reductions in arterial pressure (AP) in hypertensive patients (Patel et al. Neurology, 2011; in press). We have developed an implantable electrical stimulation system and applied it to the vlPAG of conscious, freely moving rats. AP and heart rate (HR) responses were measured via telemetry to explore potential central mechanisms.