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A retrospective survey of influencing factors on patient survival without local recurrence and total survival in patients with early cervical cancer.

OBJECTIVE
The article is based on the results of a retrospective review to observe the survival without local recurrence and the influencing factors of overall survival in patients with early cervical cancer.


METHODS
Retrospective analysis was performed on clinical and pathological data of 247 cases of early cervical cancer treated by radical resection in the period January 2011 to January 2018. Univariate and multivariate Logistic Regression Models were used to evaluate the survival without local recurrence and independent factors affecting overall survival.


RESULTS
All patients were classified by the FIGO(Federation International of Gynecology and Obstetrics) stage. The difference between adjuvant chemotherapy and brachytherapy was statistically significant (p<0.05). The median local relapse-free survival time of 247 patients was 45.0 months, and the postoperative follow-up for 2 years, 5 years and 10 years was 4.45% (11/247), 6.88% (17/247) and 8.50% (21/247), respectively. Influencing factors were, presence or absence of lymphatic vascular space infiltration, tumour diameter, whether treated with external pelvic irradiation, adjuvant chemotherapy and proximal treatment were related to local recurrence and survival of patients with early cervical cancer (p<0.05).


CONCLUSIONS
Patients with a smaller tumour size, no lymph node metastasis and external pelvic irradiation had a better overall survival. Patients with early cervical cancer should be treated with a combination of extracavitatry irradiation and brachytherapy to reduce the risk of local recurrence.