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Angiotensin converting enzyme concentrations in rabbits with talc-induced pulmonary granulomas.

Pulmonary foreign body granulomas were induced in rabbits by intravenous injection of a talc suspension, and serum angiotensin converting enzyme (ACE) concentrations were monitored for 50 days. One of 3 treated rabbits responded with a slight elevation of serum ACE in the third week after the first injection and for the remainder of the experimental period. Two treated rabbits and 2 control rabbits maintained serum ACE concentrations close to the starting values throughout the observation period of 50 days. We concluded that pulmonary talc granulomas and probably other foreign body granulomas do not elicit a major elevation of serum ACE in rabbits.