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Activities and quantities of lysosomal enzymes during mammary tumor regression.

Summary The relation of lysosomal enzymes to mammary tumor regression was studied in the highly hormone-dependent MTW9 rat mammary carcinoma. Quantities of the enzymes were determined with the use of a histochemical modification of the single radial immunodiffusion method. Major findings were as follows. ( a ) Acid phosphatase, arylsulfatase, β-galactosidase, and β-glucuronidase significantly increased in total activities after 48 hr of tumor regression. ( b ) A marked shift toward free (nonsedimentable) enzyme of each acid hydrolase occurred later in the regression process. ( c ) Regressing tumors contained larger quantities of β-galactosidase and β-glucuronidase, and the increased amounts closely corresponded to the increments in activities. ( d ) De novo synthesis of β-galactosidase and β-glucuronidase probably occurred during hormone-dependent tumor regression.