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Asperger Syndrome in Neurologic Perspective

Asperger syndrome is a pervasive developmental disorder characterized by disability in social cues and communication, fine and gross motor dyspraxia, restricted areas of perceptual integration, speech and language peculiarities, unusual prosody, and restricted areas of interest, in the presence of otherwise normal intelligence. The syndrome was first systematically described by Asperger, 1 year after the description of &dquo;infantile autism&dquo; by Kanner.2 Asperger syndrome is relatively new to the English-speaking world since the systematic English account by Wing3 and has received considerable recent attention.4,5 The individual with Asperger syndrome has symptoms similar to high functioning autism, but empirical study shows differentiation of Asperger syndrome from high functioning autism. 5,6 Asperger syndrome has been studied by brain imaging and is reported to show frontal opercular and perisylvian hypoplasia in the right, left, or both hemispheres in individual patients.’ Individuals with Asperger syndrome also have a high incidence of chromosomal disorders, epilepsy, neurocutaneous disorders, and pre-, peri-, or postnatal insult, but the etiologies of Asperger syndrome may be multiple .8,9