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[Immunohistochemical tumor diagnosis--possibilities and limitations].

Immunohistochemical techniques are becoming of steadily increasing importance as an adjunct in the diagnosis of tumours. Such investigations should always be integrated with clinical variables and routine histopathological findings, and at the same time be based on immunological expertise. There are several pitfalls in immunohistochemistry, regardless of whether monoclonal or polyclonal antibody reagents are used. In addition, the handling of the tissue specimens, both by the clinician and by the pathologist, and how the tissue sections are prepared, are of paramount importance for the immunohistochemical result. Whether this methodology is of any diagnostic help, or rather the reverse, often depends on how the pathologist and the clinician are able to evaluate aberrant immunohistochemical results obtained in the actual diagnostic setting.