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Fulminant hepatitis with severe lactate acidosis in HIV‐infected patients on didanosine therapy

We report two cases of fulminant hepatic failure in HIV‐1‐infected patients treated with didanosine (ddI). Clinical manifestations including vomiting, diarrhoea and dyspnoea were identical in both cases. Biological data mainly revealed hepatic failure and lactic acidosis. Histological examination of liver biopsies showed diffuse microvesicular steatosis. The outcome was fatal in both patients.