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Mapping pro‐ and antiangiogenic factors on the surface of prostasomes of normal and malignant cell origin

Angiogenesis is the formation of new blood vessels by capillary sprouting from pre‐existing vessels. Tumor growth is angiogenesis‐dependent and the formation of new blood vessels is associated with the increased expression of angiogenic factors. Prostasomes are secretory granules produced, stored and released by the glandular epithelial cells of the prostate. We investigated the expression of selected angiogenic and anti‐angiogenic factors on the surface of prostasomes of different origins as well as the direct effect of prostasomes on angiogenesis.