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Marital status and survival analysis of patients with pure mucinous breast carcinoma: A SEER Population-Based Retrospective study


 Background The present study was conducted to investigate the influence of marital status on survival of pure mucinous breast carcinoma based on surveillance, epidemiology, and end results (SEER) databases.Methods Data were extracted from the SEER database on eligible patients diagnosed with pure mucinous breast carcinoma between 1998 and 2015. Patients were divided into married groups and the not married groups. Survival curves were generated by the Kaplan-Meier method, and survival differences were estimated by using the Log-Rank test. Multivariate Cox Proportional Hazards Models was used to assess independent risk factors for survival.Results A total of 14972 eligible pure mucinous breast carcinoma patients were enrolled from the SEER database, including 7462 (49.84%) married and 7510 (50.16%) not married patients. The OS and CSS were significantly greater in married patients than not married patients (79.27 vs 62.49% for OS and 96.07 vs 93.34% for CSS, both P= 0.000). Among patients older than 75, there were significantly more unmarried patients than married patients (21.5% vs. 44.1%). Compared to the not married patients, cancer stage were even lower (stage I) (69.6% vs. 62.6%), (stage II) (28.6% vs. 33.9%), (stage III) (0.6% vs. 0.9%), (stage IV) (1.3% vs. 2.5%), and more patients received breast conserving surgery (67.4% vs. 62.9%), chemotherapy (15.3% vs. 11.0%) and radiation therapy (54.3% vs. 43.1%). Compared with the not married group, the proportion of non-recurrent lymph node metastasis was (82.8% vs. 74.6%) (All P= 0.000). The Multivariate Cox Proportional Hazards Models showed that marriage is an independent protective factor for OS (HR =1.356, 95% CI: 1.271-1.446, P= 0.000) and CSS (HR =1.942, 95% CI: 1.681–2.644, P= 0.000).Conclusion Marital status was an independent prognostic indicator in pure mucinous breast carcinoma patients. Research data showed that married pure mucinous breast carcinoma patients can obtain better OS and CSS than the not married patients.