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Longitudinal aortic stiffness is associated with brain microstructure and cognition: A voxel‐wise magnetic resonance imaging study

Aortic stiffness, assessed by carotid‐femoral pulse wave velocity (PWV), is closely linked with hypertension, heart disease and stroke. Recent research has suggested that rapid aortic stiffening may also be a risk factor for cognitive decline and dementia. However, the age of onset of this risk and its underlying brain physiology is unknown. We examined whether aortic stiffening over a 5‐year period in mid‐life affects later‐life brain structure and cognition in community‐dwelling adults.