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Synthesis of borate modified bioactive glass scaffold using PVP burning-out method for bone tissue replacement

Three-dimensional (3D) bioactive glass scaffolds are one of the most studied types of scaffolds for bone tissue replacement because of their excellent bioactivity and potential for stimulating osteogenesis and angiogenesis. In the present study, modified Hench- based bioglass was fabricated by polyvinyl pyrrolidone (PVP) burning-out method for producing porous scaffold. In vitro investigation of the scaffolds’ bioactivity was achieved through examining changes in its composition during exposing to physiological simulated body fluid (SBF) solution via Fourier transform-infrared (FT-IR) absorption spectroscopy, X-ray diffraction (XRD) analysis, Scanning electron microscopy (SEM) supported by Energy-dispersive X-ray (EDX). FT-IR spectral data was used to validate the formation of
hydroxyapatite as an indication of the bioactivity potential of the studied scaffold post incubation in SBF. The prepared samples were examined by XRD to recognize the crystalline phase/phases that may formed after immersion in physiological solutions and supported via (SEM/EDX) data.