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What every physician should know about the national guidelines for the control and management of sickle cell disease and the parent handbook for sickle cell disease in Nigeria

Sickle cell disease (SCD) is a genetic disorder that is caused by the inheritance of HbS, which results from the substitution of valine for glutamic acid in the 6th amino acid position of the β‐globin chain. Individuals who are homozygous for this substitution have sickle cell anemia (SCA) which is the most severe form of SCD.[1] The greatest burden of SCA is in sub‐Saharan Africa (SSA), where approximately 75% of the global 300,000 births of affected children occur with 50–80% of the children dying before adulthood.[2,3] The World Health Organization (WHO) estimates that 70% of deaths from SCD in Africa are preventable with simple and cost‐effective interventions.[3,4]