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Integrated metabolomic profiling of hepatocellular carcinoma in hepatitis C cirrhosis through GC/MS and UPLC/MS‐MS

The metabolic pathway disturbances associated with hepatocellular carcinoma (HCC) remain unsatisfactorily characterized. Determination of the metabolic alterations associated with the presence of HCC can improve our understanding of the pathophysiology of this cancer and may provide opportunities for improved disease monitoring of patients at risk for HCC development. To characterize the global metabolic alterations associated with HCC arising from hepatitis C (HCV)‐associated cirrhosis using an integrated non‐targeted metabolomics methodology employing both gas chromatography/mass spectrometry (GC/MS) and ultrahigh‐performance liquid chromatography/electrospray ionization tandem mass spectrometry (UPLC/MS‐MS).