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Structural specificity of the inhibition of serotonin accumulation in rat lung slices.

The structural specificity required for the inhibition of 5-HT accumulation in rat lung slices was determined using compounds possessing a single structural modification of the 5-HT molecule. The structural modifications involved the indole ring nitrogen atom, the alpha-carbon atom to the sidechain amine, the sidechain amine, and the substitution pattern of the indole nucleus.