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Reliability of myoelectrical manifestations of fatigue in adults with cystic fibrosis

Cystic fibrosis (CF) is a chronic hereditary disease affecting mainly the lungs and the digestive system. However, peripheral muscle dysfunction is now recognised as one of the main systemic effects of CF and contributes to the exercise intolerance and reduced quality of life (Kollmitzer et al. 1999). In this context, evaluation of muscular function shows clinical relevance in CF. Functional non-invasive assessment of skeletal muscles is usually obtained with the study of muscle fatigue. Surface electromyographic (sEMG) method for neuromuscular fatigue study is well accepted by the research community and spreading in the clinical world as assessment tools. Assessment of repeatability is unavoidable to demonstrate the potential clinical utility of a technique in a given population. The purpose of this study is therefore to test the validity of frequency domain EMG measurements in adults with CF during fatiguing isometric contractions.