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Effects of Oral Rho Kinase Inhibitor Fasudil on Detrusor Overactivity after Bladder Outlet Obstruction in Rats

Objectives: Bladder outlet obstruction (BOO)‐related detrusor hypertrophy is associated with upregulation of Rho‐kinase (ROCK) activity in an experimental animal model, and has been implicated in BOO‐induced bladder dysfunction. The aim of this study was to test whether chronic oral administration of an oral ROCK inhibitor, fasudil (HA1077, 5‐isoquinolinesulfonyl homopiperazine), could prevent the development of both detrusor hypertrophy and detrusor overactivity in rat model.