{'fraction_non_alphanumeric': 0.022396416573348264, 'fraction_numerical': 0.0341545352743561, 'mean_word_length': 4.976588628762542, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
A study on the impact of elevated estradiol levels in frozen-embryo transfer cycles on pregnancy rates

Aims and Objectives: To determine whether raised estradiol (E2) levels administered before progesterone supplementation in frozen-embryo transfer cycles have an impact on the rates of pregnancy. Materials and Methods: A retrospective study of 242 patients who had their frozen embryo replacement cycles conducted at Southend Fertility and IVF Centre between September 2014 and April 2017. In all these patients, a baseline pelvic scan was carried out and endometrial preparation was carried out as per six different protocols. After desired endometrial lining was observed, E2 levels were measured prior to progesterone supplementation, and the impact of raised E2 levels on pregnancy outcomes was evaluated in six different protocols. Pregnancy outcome was evaluated by measuring serum beta human chorionic gonadotropin levels 16 days after the embryo transfer. Statistical analysis was performed by using standard methods and receiver operating characteristic curves plotted to compare the outcomes. Results: Mean age of the patients in the study group was 34.35 ± 6.12 years, most of the patients were less than 40 years of age and mean parity was 0.49 ± 0.55. E2 level was measured on day 2 or 3 of cycle, and mean E2 level was 11.83 ± 5.50 pg/ml. Endometrial preparation was performed with injectable or oral hormonal preparations using six different protocols. Mean peak E2 level was 1263.65 pg/ml in 149 patients with no pregnancy and 1445.01 pg/ml in 93 patients with pregnancy in all protocols. Conclusion: Elevated E2 levels had no statistically significant impact on pregnancy rates in six different study protocols (oral and injectable) used for endometrial preparation.