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Comparative tumor localization of whole immunoglobulin g anticarcinoembryonic antigen monoclonal antibodies immu‐4 and immu‐4 f(ab′)2 in colorectal cancer patients

Background. Previous studies in the literature have suggested that radiolabeled F(ab′)2 fragments might be superior to whole immunoglobulin G (IgG) for imaging and therapy of cancer because of their greater penetration in tumors. To test this hypothesis, the authors compared tumor and normal tissue uptake along with plasma clearance of 125I‐labeled monoclonal antibody (MoAb) IMMU‐4 whole IgG with its 131I‐labeled F(ab′)2 fragment.