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Cytotoxicities and Structure–Activity Relationships of Natural and Unnatural Lamellarins toward Cancer Cell Lines

Shedding light on the lamellarins: Structural determinants for potent cytotoxic activity toward various cancer cell lines were systematically investigated to establish SARs for the marine alkaloids in the lamellarin family. The C5C6 double bond ensures not only the planarity of the D‐ring, but also proper alignment of the substituents on the E‐ring with their respective moieties of the target. The importance of the C7 OH group is also revealed for the first time.