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[Secretory patterns of the luteinizing hormone-releasing hormone in female rats (author's transl)].

To get more insight into the hypothalamic control of gonadotropin secretion, we attempted to define the secretory patterns of the luteinizing hormone-releasing hormone (LH-RH), by measuring hypothalamic LH-RH contents as well as by observing the effects of immunoneutralization of endogenous LH-RH on serum gonadotropin levels. Female rats of Wister and Fischer strain with regular 4 or 5 day estrous cycles were used. They were raised in a light controlled (from 5:00 to 19:00), air conditioned room. Concentrations of serum and pituitary gonadotropins were measured by double antibody radioimmunoassay with NIAMDD kits and anti-LH serum from Dr. G.D. Niswender. Hy-