{'fraction_non_alphanumeric': 0.01870748299319728, 'fraction_numerical': 0.0, 'mean_word_length': 5.1947368421052635, 'pattern_counts': {'":': 0, '<': 0, '<?xml version=': 0, '>': 0, 'https://': 0, 'lorem ipsum': 0, 'www.': 0, 'xml': 0}, 'pii_count': 0, 'substrings_counts': 0, 'word_list_counts': {'cursed_substrings.json': 0, 'profanity_word_list.json': 0, 'sexual_word_list.json': 0, 'zh_pornsignals.json': 0}}
ASSESSMENT OF TRANSMEMBRANE POTENTIAL WHEN A DC CURRENT IS APPLIED IN THE TUMOR REGION

The mechanisms of antitumor effects associated with the Electro Current Therapy (ECT) - treatment that consists of a DC current flow in the tumor region - are not well understood. So, the aim of this paper is to present a Tumor Cellular Model to evaluate the potential profile developed across the cellular membrane, which separates the intracellular and extracellular spaces, when a DC current is applied in the cancerous area. The diffusion of ions, due this DC current, through the cellular membrane generates a transmembrane potential. The potential profile across cellular membrane is evaluated by the use of an analytical method applied over the conceived Tumor Cellular Model. The Tumor Cellular Model has two merits. The first, it express the discrete phenomena through macroscopic behavior where discrete structure of intra and extracellular (and the cellular membrane) spaces are defined everywhere by average values over many cells. The second, the tumor model will allow us to represent this complex biological structure (tumoral cells) through equivalent electrical circuits.