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[Functional capacity of T cell subpopulations in mice. II. Effect of allogeneically stimulated T-cell subpopulations on the primary MLR].

The effect of allogeneically stimulated lymphocytes or their subpopulations respectively on a primary allogeneic MLC was studied. It was shown that this effect depends either on the amount of the transferred cells or on the composition of the culture medium. In contradiction to the common view that allogeneically stimulated lymphocytes act as suppressor cells, a significant stimulating effect, mediated by these cells, could be demonstrated under respective conditions. Also in the experiments with the subpopulations of allogeneically stimulated lymphocytes the effects of these cells are rather influenced by the conditions then determined by a restricted functional repertoire of the cells.