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Breaching the 10-second barrier of total analysis time for complex matrices via Automated Coated Blade Spray.

In the development of modern analytical workflows, parameters such as sample turnaround time, cost of analysis, and ease of use must be prioritized. Automation enables reductions in total analysis time, human intervention, and cost per sample. In this report, a suitable automated coated blade spray (CBS) workflow is proposed for the screening and quantitation of multiple substances (i.e. drugs of abuse and pesticides) in complex matrices. In an attempt to reduce the total sample-analysis time, several parameters were investigated, including tandem mass-spectrometry (MS) dwell time, CBS spray time, and extraction time. SPME method parameters are explored, such as reduction of extraction time for increased signal-to-noise. Model compounds with a moderately wide range of molecular weights (150-500 Da), polarities, and structural diversity were selected in order to monitor analytical figures of merit during method optimization. The resultant automated CBS method proved capable of analyzing the model compounds in human urine in under 10 seconds total analysis time with excellent accuracy (95-120 %) and precision (RSD < 12 %). As an application, an automated method for the screening and quantitation of more than 150 pesticides from apple juice was demonstrated on both triple quadrupole and orbitrap instruments in under 15 second total sample analysis time.