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Association of Demographic and Occupational Factors with SARS-CoV-2 Vaccine Uptake in Kenya

The outbreak of the Severe Acute Respiratory Syndrome Coronavirus 2 has triggered adoption and diffusion of public and infection control measures. After numerous clinical trials, various brands of vaccines were developed to attenuate further spread of the virus. The vaccines come at a time when misinformation is scuttling synergies to fight the flu-like disease. Uncertainty surrounding the safety of the vaccines translates to fear of health outcomes among users yet hesitancy in vaccine uptake has direct threats to health. Using a digital cross-sectional survey data among 171 respondents that was conducted between 2 nd March and 5 th March 2021, the study reveals variation on the update of the vaccine. The study recommends public sensitization and education about the vaccines for greater proportion of acceptance and uptake.


Background
The 2019 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) broke out in a wet market in Wuhan, Hubei province, China at the end of 2019 (Xiang et al., 2020) [1]. The disease was later declared as a Public Health Emer- Vaccine Uptake in Kenya. Open Access Library Journal, 8: e7424. (WHO) in January 2020 and as a global pandemic in March 2020.
Kenya confirmed the first case of SARS-CoV-2 on 12 March 2020. A year on, more than 109,643 cases (an equivalent of 2.7% of all African cases) and 1,886 deaths had been reported. As the number of cases continued to soar, experts warned about emergence of variants that could be difficult to manage (WHO, 2021) [2]. The mutating nature of SARS-CoV-2 necessitates stricter adherence to mitigation measures that include isolations and quarantines, handwashing with soap or alcohol-based sanitizers and use of face coverings.
Although clinical research has provided apposite information about the structure and behavior of the mutating air-borne virus and the widened prospects for the development of an effective vaccine, there is uncertainty on the safety and effectiveness of the vaccines, issues that are largely attributable to ethics, history and conspiracy. Kenya was among other first African countries that received the first batch of AstraZeneca vaccines amid speculation, mainly in Europe, that the vaccine causes blood clots (see Dyer, 2021 [3]; Wise, 2021 [4]).
Outside Africa, studies reveal a sizable proportion in hesitancy for inoculation. This is despite assurances that inoculation benefits far outweigh the risks. Padhi and Al-Mohaithef (2020) [5] have observed that successful inoculation is context-specific and varies with geography and socio-demographics, an issue the article sought to ascertain.  [10]), more than a dozen vaccines have been developed and approved. The efficacy of many more is being tested. Kazi and Mursheda (2020) [11] have argued that it is through these efforts that the world will attenuate and fully eradicate the disease.

Methodology
The study employed a cross-sectional survey, using a quantitative technique to establish the determinants of SARS-CoV-2 vaccine acceptance and uptake in Kenya. An online, self-designed questionnaire of opinion and attitude, which was hosted on Google was used. The questionnaire contained short, simple yet relevant questions on the respondents' perceptions on the uptake of the SARS-CoV-2 vaccine. Consistency and neutrality in questioning was ensured and no bias or emotional elements were asked. The survey link was shared via email. For ethical purposes, the respondents were auto-directed to the informed consent page and allowed to fill out the form, which remained open for four days between 2 nd March and 5 th March, 2021.
The Cochran formula was used in computation of the sample size. The formula is given as:

Methodological Assumption
For purposes of this study, it is assumed that the Google Form developed, was only shared within Kenya and filled out by respondents of consenting age and of desired attributes. Anonymized data was used for analysis and interpretation. No individual information or data that may lead to identity disclosure was gathered or included in this study.

Results and Discussion
A total of 171 respondents participated in the study. This was an equivalent of 77% of the desired sample size. Out of this number, 60% were male and approximately two-thirds (66%) were aged between 36 -60 years old. As shown in Table 1, the number of respondents who had a degree and post-graduate degree was proportionate, at 68 and 67, respectively.
Although 98.2% of the respondents were aware of the availability of SARS-CoV-2 vaccine around the world, nearly half (47.3%) reported watching television as their source of information about the pandemic. Other statistics are revealed in Table 2.
Among the participants (n = 170) who responded to the question on willingness to receive the COVID-19 vaccine, only slightly above average (52.4%) were willing to be inoculated. Out of those who were unwilling to be inoculated, the majority alleged concerns on the side effects. A Chi − square test revealed only profession of the respondents was significant, X 2 (1, N = 170) = 5.321, p = 0.021) as revealed on Table 3.
Studies reveal that vaccines are needed to attenuate spread of SARS-CoV-2

Conclusions
New

Recommendations
The study finding revealed that unfounded fear about the potential side effects of the vaccines alongside safety and misinformation were leading drivers attributable to the low scale of acceptance of the vaccine(s) among the general public. To turn around this perception, the Ministry of Health should encourage public sensitization and education about the vaccine through available channels, mainly TV and social media. Lastly, given that men are more likely to be inoculated that women, a gendered approach to reverse vaccine scepticism is needed.

Limitation of the Study
The online survey, which was used in the study is not without its own limitations. It tends to exclude uneducated majority of the general public.
The perceived uncertainties around the SARS-CoV-2 vaccine uptake were restricted to the AstraZeneca vaccine. Plausibly, had respondents been presented with an array of vaccine brands that would have provided choice among users leading to overly different results. Perhaps, continued monitoring of trends on uptake could have provided meaningful insights on behavioural change over time. Beyond the assurance given by the government (and the manufacturer) on the safety of the vaccines, no experiment was carried out to bolster or weaken the assurances.