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Repeated capsaicin patch applications in patients
with localized peripheral neuropathic pain

Neuropathic pain is still a challenging problem. It is experienced by millions of people worldwide, with an
approximate prevalence of 7‒10% in the general population. Despite the availability of a variety of treatment methods,
a significant proportion of patients suffer from poorly controlled neuropathic pain. Capsaicin is a highly selective TRPV1
(Transient Receptor Potential Vanilloid Type 1) agonist. When applied topically, it leads to the defunctionalisation
of hyperactive nociceptive receptors, temporary destruction of peripheral nerve endings, and a significant reduction
or cessation of pain. Therefore 8% capsaicin patches are used to treat several peripheral, localized neuropathic pain
syndromes. The study aimed to present a case series of patients suffering from peripheral, localized neuropathic pain
in case the use of repeated applications of 8% capsaicin patches significantly reduced the intensity of pain. In 5 out of
6 patients we observed a gradual extension of the pain relief period until the pain disappeared, which led to the reduction or
discontinuation of systemic pharmacotherapy. In summary, a therapy limited to a certain area of the body, without potential
systemic adverse effects, which requires repetition at fairly long intervals, appears to be a good treatment option.

