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Intestinal adaptations in chronic kidney disease and the influence of gastric bypass surgery

What is the topic of this review? This review primarily focuses on the compensatory adaptations in gastrointestinal oxalate transport that can impact urinary oxalate excretion in the context of hyperoxaluria, a major risk factor in kidney stone disease. What advances does it highlight? The intestine, which is generally considered an absorptive organ, contributes to oxalate homeostasis by playing a role in enteric elimination/excretion of oxalate that has beneficial effects, especially when renal function is compromised. Conversely, when enteric elimination of oxalate is promoted, urinary oxalate can be reduced even in hyperoxaluric conditions. This report highlights the physiological signalling between the kidney and the gut and vice versa.