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Association analysis of miR‐499 rs3746444 gene polymorphism with periodontitis

Periodontitis is a chronic inflammatory disease. The innate immune mechanism plays a significant role in the aetiopathogenesis of periodontal destruction. The innate immune signalling molecular factors are regulated by small noncoding RNAs called microRNAs (miRNAs). miR‐499 targets many inflammatory cytokine gene mRNAs and has been associated with many inflammatory diseases like rheumatoid arthritis and cardiovascular diseases. Single nucleotide polymorphisms (SNPs) are found to be genetic factors of periodontitis. Not much information is available on miRNA SNP and periodontitis. Thus, the aim of the present study was to find the association of miR‐499 rs3746444 gene polymorphism with chronic periodontitis, aggressive periodontitis and healthy controls.