Dataset Information


The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies.

ABSTRACT: Inflammation is a recognized hallmark of cancer that contributes to the development and progression of colorectal cancer (CRC). Anti-inflammatory drugs currently used for the treatment of CRC show many adverse side effects that prompted researchers to propose the polyunsaturated fatty acids-derived specialized pro-resolving mediators (SPMs) as promoters of resolution of cancer-associated inflammation. SPMs were found to inhibit the CRC-associated pro-inflammatory milieu via specific G-coupled protein receptors, although clinical data are still lacking. This review aims to summarize the state-of-the-art in this field, ultimately providing insights for the development of innovative anti-CRC therapies that promote the endogenous lipid-mediated resolution of CRC-associated inflammation.


PROVIDER: S-EPMC7463689 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6537608 | BioStudies
2012-01-01 | S-EPMC3340015 | BioStudies
2018-01-01 | S-EPMC6118638 | BioStudies
2013-01-01 | S-EPMC3662318 | BioStudies
2020-01-01 | S-EPMC7493015 | BioStudies
2018-01-01 | S-EPMC5926908 | BioStudies
2016-01-01 | S-EPMC5242505 | BioStudies
2019-01-01 | S-EPMC6454233 | BioStudies
1000-01-01 | S-EPMC5036151 | BioStudies
2016-01-01 | S-EPMC4824659 | BioStudies