text: **Fig. 3 | Subcortical GMV changed throughout gestation. a**, Multivariate 
  regression analyses revealed largely negative relationships between gestation 
  week and subcortical GMV regions over pregnancy, including bilateral thalamus, 
  caudate, hippocampus, ventral diencephalon (encompassing hypothalamus, 
  substantia nigra, mammillary body and red nucleus) and left caudate. Lateral 
  ventricles displayed the only positive relationships with gestation week 
  (also depicted in Fig. 1d). The whole-brain subcortical GMV estimates shown 
  here were derived via FreeSurfer and ‘aseg’ subcortical segmentation. FDR- 
  corrected at*q*< 0.05. Inset, right ventral diencephalon displayed the strongest 
  negative association with gestation (left; baseline—36 weeks, 19 scans) and did 
  not return to baseline postpartum (right; gestation and postpartum, 26 scans). 
  **b**, The participant’s hippocampus and surrounding cortex were segmented 
  into seven bilateral subregions. Quadratic (CA1, CA2/CA3) and linear regression 
  analyses (PHC) revealed subfields were negatively associated with gestation 
  week (baseline—36 weeks, 18 scans) and did not return to baseline postpartum 
  (gestation and postpartum, 25 scans). Shaded regions in scatterplots represent 
  a 95% confidence interval. Each boxplot represents IQR for each stage, with a 
  horizontal line representing the median value. The whiskers indicate variability 
  outside (±1.5) of this range. Outside values are >1.5× and <3× IQR beyond either 
  end of the box. FDR-corrected at*q*< 0.05. For**a**and**b**, nonsignificant regions 
  were set to zero for interpretability. See Supplementary Fig. 6 for complete 
  labeling of regions in both segmentations. Brain visualizations created with R 
  package ggseg48*.*DC, diencephalon. 