DRG neuron death following nerve injury. One study which
developed a deep learning approach to assess rat DRG cellular
plasticity found no loss of neurons up to 2 weeks post-SNI,49
while another observed no loss of genetically labelled damaged
DRG neurons 2 months after sciatic nerve crush.44
The issue of whether neuron loss occurs, and if so, in what
subpopulations, is important. It will likely have implications for our
understanding of reinnervation and functional recovery in patients.
Furthermore, better insight will provide critical context for those
investigating the plasticity that occurs following nerve injury and
may inform therapeutic targeting of sensory neuron populations.
An expanding repertoire of transgenic recombinase driver lines
now makes it possible to permanently label DRG neuron
subpopulations and study their fate in rodent nerve injury paradigms.
The aim of this study was to use this technology to characterize
Sponsorships or competing interests that may be relevant to content are disclosed
at the end of this article.
a School of Psychology and Neuroscience, University of Glasgow, Glasgow,
United Kingdom,b Nuffield Department of Clinical Neurosciences, University of
Oxford, Oxford, United Kingdom
*Corresponding author. Address: School of Psychology and Neuroscience,
University of Glasgow, Glasgow G12 8QQ, United Kingdom. Tel.:144 (0) 141 330
7023. E-mail address: gregory.weir@glasgow.ac.uk (G.A. Weir).
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http://dx.doi.org/10.1097/j.pain.0000000000003321
December 2024 ·Volume 165 ·Number 12 www.painjournalonline.com 2863