Assessment of dyspnea in asthma:
validation of The Dyspnea-12.J Asthma.
2011;48(6):602-608.
27. Boulet LP, Boulay ME, Cote A, et al.
Airway inﬂammation and
hyperresponsiveness in subjects with
respiratory symptoms and normal
spirometry. Eur Respir J. 2023;61(3):
2201194.
28. Gerstein E, Bierbrier J, Whitmore GA,
et al. Impact of undiagnosed chronic
obstructive pulmonary disease and asthma
on symptoms, quality of life, healthcare
use, and work productivity.Am J Respir
Crit Care Med. 2023;208(12):1271-1282.
29. Aaron SD, Vandemheen K,
Whitmore GA, et al. Early diagnosis and
treatment of COPD and asthma: a
randomized, controlled trial.N Engl J
Med. 2024;390(22):2061-2073.
30. Han MK, Ye W, Wang D, et al.
Bronchodilators in tobacco-exposed
persons with symptoms and preserved
lung function.N Engl J Med. 2022;387(13):
1173-1184.
31. Marott JL, Ingebrigtsen TS, Çolak Y, et al.
Impact of the metabolic syndrome on
cardiopulmonary morbidity and mortality
in individuals with lung function
impairment: a prospective cohort study of
the Danish general population.Lancet Reg
Health Eur. 2023;35:100759.
32. Stefan MS, Priya A, Martin B, et al. How
well do patients and providers agree on
the severity of dyspnea?J Hosp Med.
2016;11(10):701-707.
33. Cherian M, Magner KMA, Whitmore GA,
et al. Patient and physician factors
associated with symptomatic undiagnosed
asthma or COPD.Eur Respir J. 2023;61(2):
2201721.
1308 Original Research [ 166#6 CHEST DECEMBER 2024 ]