an industrial partnership grant from the BBSRC and AstraZeneca.
The remaining authors have no conflicts of interest to declare.
Data are available on request to lead contact G.-
A.W.—gregory.weir@glasgow.ac.uk. Further information and
requests for reagents and/or reagents used in this study should
also be directed to G.A.W., and we will endeavour to fulfil these.
Acknowledgments
The authors thank Dr Mark Hoon for providing the Trpm8-Flp
transgenic mouse line and Prof Andrew Todd and Dr David
Hughes for their critical feedback on the manuscript. Neuron and
ganglion illustrations in Figure 1 and S1 (http://links.lww.com/
PAIN/C84) were adapted from images provided by Servier
Medical Art, licensed under CC BY 4.0. The research was funded
by an MRC Fellowship grant awarded to GAW. (MR/T01072X/1)
and a Tenovus Scotland Pilot Grant awarded to AHC and GAW
(S22-17). This work was also funded by the Wellcome Trust (DPhil
scholarship to AMB, 215145/Z/18/Z) and a Wellcome Investiga-
tor Grant to D.L.B. (223149/Z/21/Z), as well as the MRC (MR/
T020113/1), and with funding from the MRC and Versus Arthritis
to the PAINSTORM consortium as part of the Advanced Pain
Discovery Platform (MR/W002388/1). AMB further received
a GTC MSDTC Scholarship.
Supplemental digital content
Supplemental digital content associated with this article can be
found online at http://links.lww.com/PAIN/C84.
Supplemental video content
Video content associated with this article can be found on the
PAIN Web site.
Article history:
Received 14 November 2023
Received in revised form 11 April 2024
Accepted 25 May 2024
Available online 15 August 2024
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