He was a member of the Harrison family of Virginia–a grandson of the ninth president, William Henry Harrison, and a great-grandson of Benjamin Harrison V, a Founding Father.
Harrison was born on a farm by the Ohio River and graduated from Miami University in Oxford, Ohio. After moving to Indianapolis, he established himself as a prominent local attorney, Presbyterian church leader, and politician in Indiana. During the American Civil War, he served in the Union Army as a colonel, and was confirmed by the U.S. Senate as a brevet brigadier general of volunteers in 1865. Harrison unsuccessfully ran for governor of Indiana in 1876. The Indiana General Assembly elected Harrison to a six-year term in the Senate, where he served from 1881 to 1887.
A Republican, Harrison was elected to the presidency in 1888, defeating the Democratic incumbent Grover Cleveland in the Electoral College despite losing the popular vote. Hallmarks of Harrison's administration included unprecedented economic legislation, including the McKinley Tariff, which imposed historic protective trade rates, and the Sherman Antitrust Act. Harrison also facilitated the creation of the national forest reserves through an amendment to the Land Revision Act of 1891. 