He defended Jackson for vetoing the Maysville Road funding project, which Jackson considered unconstitutional.[43] He voted to confirm several of Jackson's appointments, including Jackson's future running mate Martin Van Buren as United States Minister to Britain.[44] The leading issue in the 1832 presidential election was the recharter of the Second Bank of the United States, which both Tyler and Jackson opposed. Congress voted to recharter the bank in July 1832, and Jackson vetoed the bill for both constitutional and practical reasons. Tyler voted to sustain the veto and endorsed Jackson in his successful bid for reelection.[45]

Break with the Democratic Party
Tyler's uneasy relationship with his party came to a head during the 22nd Congress, as the nullification crisis of 1832–1833 began. South Carolina, threatening secession, passed the Ordinance of Nullification in November 1832, declaring the "Tariff of Abominations" null and void within its borders. This raised the constitutional question of whether states could nullify federal laws. Jackson, who denied such a right, prepared to sign a Force Bill allowing the federal government to use military action to enforce the tariff. 