where do you find phospholipids in a cell
cell membranes
324127
a dietary supplement. Lysolecithins are typically used for water-oil emulsions like margarine, due to their higher HLB ratio. Phospholipid Phospholipids are a class of lipids that are a major component of all cell membranes. They can form lipid bilayers because of their amphiphilic characteristic. The structure of the phospholipid molecule generally consists of two hydrophobic fatty acid "tails" and a hydrophilic "head" consisting of a phosphate group. The two components are joined together by a glycerol molecule. The phosphate groups can be modified with simple organic molecules such as choline, ethanolamine or serine. The first phospholipid identified in 1847 as
Phospholipid
7417790
which then triggers antimicrobial action. The principal defense molecules secreted by Paneth cells are alpha-defensins, which are known as cryptdins in mice. These peptides have hydrophobic and positively charged domains that can interact with phospholipids in cell membranes. This structure allows defensins to insert into membranes, where they interact with one another to form pores that disrupt membrane function, leading to cell lysis. Due to the higher concentration of negatively charged phospholipids in bacterial than vertebrate cell membranes, defensins preferentially bind to and disrupt bacterial cells, sparing the cells they are functioning to protect. Paneth cells are stimulated to secrete
Paneth cell
12425344
life forms, showing that archaea are related only distantly to bacteria and eukaryotes. In all organisms, cell membranes are made of molecules known as phospholipids. These molecules possess both a polar part that dissolves in water (the phosphate "head"), and a "greasy" non-polar part that does not (the lipid tail). These dissimilar parts are connected by a glycerol moiety. In water, phospholipids cluster, with the heads facing the water and the tails facing away from it. The major structure in cell membranes is a double layer of these phospholipids, which is called a lipid bilayer. The phospholipids of archaea are
Archaea
238123
General Lipid In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents. Non-polar solvents are typically hydrocarbons used to dissolve other naturally occurring hydrocarbon lipid molecules that do not (or do not easily) dissolve in water, including fatty acids, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E, and K), monoglycerides, diglycerides, triglycerides, and phospholipids. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes. Lipids have applications in the cosmetic and food industries as well as in nanotechnology. Scientists sometimes broadly define lipids as hydrophobic or amphiphilic
Lipid
238087
Lipid In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents. Non-polar solvents are typically hydrocarbons used to dissolve other naturally occurring hydrocarbon lipid molecules that do not (or do not easily) dissolve in water, including fatty acids, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E, and K), monoglycerides, diglycerides, triglycerides, and phospholipids. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes. Lipids have applications in the cosmetic and food industries as well as in nanotechnology. Scientists sometimes broadly define lipids as hydrophobic or amphiphilic small
Lipid
654789
insulin resistance within days or even hours in response to a large lipid influx. Draining the intracellular reserves, on the other hand, is more challenging: moderate caloric restriction alone, even over a period of several months, appears to be ineffective, and it must be combined with physical exercise to have any effect. In the long term, diet has the potential to change the ratio of polyunsaturated to saturated phospholipids in cell membranes, correspondingly changing cell membrane fluidity; full impact of such changes is not fully understood, but it is known that the percentage of polyunsaturated phospholipids is strongly inversely correlated
Insulin resistance
20745708
whose cholinergic activity is impaired in many neurodegenerative diseases including Alzheimer’s. While there was uptake of the tracer in the brain, no pharmacokinetic pattern was found. Carbon-11 choline has found more success in cancer systems imaging. Choline is a precursor for the synthesis of phospholipids. When a cell is about to divide, it synthesizes these phospholipids to generate enough material to build the cell membranes of the two daughter cells. Thus it was hypothesized that highly proliferative tumors would uptake more choline than the surrounding healthy tissue. This was first tested in brain tumors after successful demonstration of choline uptake
Carbon-11-choline
5341618
has been used to delineate in atomic detail how the family of plant defensins rupture membranes by identifying key phospholipids in the cell membranes of the pathogen. Human defensins have been thought to act through a similar mechanism, targeting cell membrane lipids as part of their function. In fact human beta-defensin 2 have now been shown to kill the pathogenic fungi "Candida albicans" through interactions with specific phospholipids. Antimicrobial peptides have been used as therapeutic agents; their use is generally limited to intravenous administration or topical applications due to their short half-lives. As of January 2018 the following antimicrobial peptides
Antimicrobial peptides
4493394
atoms of the original glycerol can be oxidized via glycolysis, or converted to glucose via gluconeogenesis. Fatty acids are an integral part of the phospholipids that make up the bulk of the plasma membranes, or cell membranes, of cells. These phospholipids can be cleaved into diacylglycerol (DAG) and inositol trisphosphate (IP) through hydrolysis of the phospholipid, phosphatidylinositol 4,5-bisphosphate (PIP), by the cell membrane bound enzyme phospholipase C (PLC). An example of a diacyl-glycerol shown on the right. This DAG is 1-palmitoyl-2-oleoyl-glycerol, which contains side-chains derived from palmitic acid and oleic acid. Diacylglycerols can also have many other combinations of fatty
Fatty acid metabolism
1268108
Steroids and their metabolites often function as signalling molecules (the most notable examples are steroid hormones), and steroids and phospholipids are components of cell membranes. Steroids such as cholesterol decrease membrane fluidity. Similar to lipids, steroids are highly concentrated energy stores. However, they are not typically sources of energy; in mammals, they are normally metabolized and excreted. Steroids play critical roles in a number of disorders, including malignancies like prostate cancer, where steroid production inside and outside the tumour promotes cancer cell aggressiveness. The hundreds of steroids found in animals, fungi, and plants are made from lanosterol (in animals and
Steroid
8242567
the incorporated drug and ability for sterilization using standard methods which do not affect drug structure or efficacy. Phosphorylcholine Phosphorylcholine (abbreviated ChoP) is the hydrophilic polar head group of some phospholipids, which is composed of a negatively charged phosphate bonded to a small, positively charged choline group. Phosphorylcholine is part of platelet-activating factor; the phospholipid phosphatidylcholine as well as sphingomyelin, the only phospholipid of the membrane that is not built with a glycerol backbone. Treatment of cell membranes, like those of RBCs, by certain enzymes, like some phospholipase A2 renders the phosphorylcholine moiety exposed to the external aqueous phase, and
Phosphorylcholine
81333
Specially designed vegetarian experimental diets have been produced yielding upwards of 700 mg/day. Cholesterol, given that it composes about 30% of all animal cell membranes, is required to build and maintain membranes and modulates membrane fluidity over the range of physiological temperatures. The hydroxyl group of each cholesterol molecule interacts with the water molecules surrounding the membrane as do the polar heads of the membrane phospholipids and sphingolipids, while the bulky steroid and the hydrocarbon chain are embedded in the membrane, alongside the nonpolar fatty-acid chain of the other lipids. Through the interaction with the phospholipid fatty-acid chains, cholesterol increases
Cholesterol
5718162
CHON CHON is a mnemonic acronym for the four most common elements in living organisms: carbon, hydrogen, oxygen, and nitrogen. The acronym CHNOPS, which stands for carbon, hydrogen, nitrogen, oxygen, phosphorus, sulfur, represents the six most important chemical elements whose covalent combinations make up most biological molecules on Earth. Most of the elements are nonmetals. Sulfur is contained in the amino acids cysteine and methionine. Phosphorus is contained in phospholipids, a class of lipids that are a major component of all cell membranes, as they can form lipid bilayers, which keep ions, proteins, and other molecules where they are needed
CHON
581383
on Titan's surface." In February 2015, a hypothetical cell membrane capable of functioning in liquid methane in Titan conditions was modeled. Composed of small molecules containing carbon, hydrogen, and nitrogen, it would have the same stability and flexibility as cell membranes on Earth, which are composed of phospholipids, compounds of carbon, hydrogen, oxygen, and phosphorus. This hypothetical cell membrane was termed an "azotosome", a combination of "azote", French for nitrogen, and "liposome". Despite these biological possibilities, there are formidable obstacles to life on Titan, and any analogy to Earth is inexact. At a vast distance from the Sun, Titan is
Titan (moon)
3700431
has recently been called into question due to ambiguities in the lipids and proteins recovered and the observation that they can also cause solid areas to form where there were none previously. Until 1982, it was widely accepted that phospholipids and membrane proteins were randomly distributed in cell membranes, according to the Singer-Nicolson fluid mosaic model, published in 1972. However, membrane microdomains were postulated in the 1970s using biophysical approaches by Stier & Sackmann and Klausner & Karnovsky. These microdomains were attributed to the physical properties and organization of lipid mixtures by Stier & Sackmann and Israelachvili et al. In
Lipid raft
10081691
regulation, however, involves its interaction with the cell membrane, not direct interaction with specific molecules. The cell membrane consists of phospholipids. At warmer temperatures, phospholipids exist in a more fluid state as a result of increased intramolecular motion. The more fluid the cell membrane, the greater PKC-α’s activity. At cooler temperatures, phospholipids are found in a solid state with constricted motion. As phospholipids become stationary, they assume a particular orientation within the membrane. Phospholipids that solidify at an irregular or angled orientation with respect to the membrane, can reduce PKC-α’s activity. The composition of the cell membrane can also affect
PKC alpha
4392096
of apoptosis), no longer actively manage the distribution of phospholipids in their outer membrane and hence begin to display negatively charged phospholipids, such as phosphatidyl serine, on the cell surface. In healthy cells, an ATP (Adenosine triphosphate)-dependent enzyme removes these from the outer leaflet of the cell membrane. These negatively charged phospholipids are recognized by phagocytes such as macrophages. Protein S can bind to the negatively charged phospholipids and function as a bridging molecule between the apoptotic cell and the phagocyte. The bridging property of Protein S enhances the phagocytosis of the apoptotic cell, allowing it to be removed 'cleanly'
Protein S
766120
among the bilayer is the result of the function of several energy-dependent and energy-independent phospholipid transport proteins. Proteins called “Flippases” move phospholipids from the outer to the inner monolayer, while others called “floppases” do the opposite operation, against a concentration gradient in an energy dependent manner. Additionally, there are also “scramblase” proteins that move phospholipids in both directions at the same time, down their concentration gradients in an energy independent manner. There is still considerable debate ongoing regarding the identity of these membrane maintenance proteins in the red cell membrane. The maintenance of an asymmetric phospholipid distribution in the bilayer
Red blood cell
8060121
tissues. Removal of apoptotic cells is carried out via phagocytosis by white blood cells such as macrophages and dendritic cells. Phagocytic white blood cells recognize apoptotic cells by their exposure of negatively charged phospholipids (phosphatidylserine) on the cell surface. In normal cells, the negative phospholipids reside on the inner side of the cellular membrane while the outer surface of the membrane is occupied by uncharged phospholipids. After a cell has entered apoptosis, the negatively charged phospholipids are transported to the outer cell surface by a hypothetical protein known as scramblase. Phagocytic white blood cells express a receptor that can bind
Annexin A5 affinity assay
19005414
also shown that the venom of "P. Polybia" contains an antimicrobial agent, Mastoparan, that inhibits all developmental forms of "Trypanosoma cruzi", the parasite that is responsible for Chagas disease. "P. paulista" features a peptide Polybia-MP1 that causes increased permeability in cells featuring phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the outer membrane. As cancer cells feature the PS and PE phospholipids on the outside of the cell membrane, unlike with non-cancerous cells where they usually remain on the inside of the cell membrane, they are susceptible to the peptide which causes increased cell permeability to a degree that molecules critical
Polybia paulista
11223766
a phospholipid, lysophosphatidylcholine (LPC), and a Sphingomyelin, sphingosylphosphorylcholine. However, these studies did not give evidence that these lyso-phospholipids actually bound to G2A; some 4 years later this report was withdrawn. Nonetheless, many of LPC's activities do depend on G2A; more recent data suggest that rather than acting directly as a ligand that binds to G2A, LPC alters G2A's distribution within the cell by increasing its movement from the cell interior to the cell surface and/or by preventing its movement away from the cell surface to the cell interior. That is, in neutrophils and other cell types which have internal stores
GPR132
13098182
from his cell phone to find the answer to what is the point of being good. This play falls under the genre of a classic tragedy. It starts with a state of equilibrium where there is a basic moral code. In "Patience" it is if you do your work you will be rewarded. Reuben worked hard at his job and became successful. He had a girl fall in love with him and they got married and had kids. Then the inciting incident happens when a character commits an act of shame. Reuben's business partners find that he has stolen from
Patience (play)
183499
an alcohol. It is an essential structural component of cell membrane, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and vitamin D. Although cholesterol is an important and necessary molecule, a high level of serum cholesterol is an indicator for diseases such as heart disease. About 20-25% of total daily cholesterol production occurs in the liver. Phospholipids: Phospholipids are TGs that are covalently bonded to a phosphate group by an ester linkage. Phospholipids perform important functions including regulating membrane permeability and in
High-density lipoprotein
8112072
inherited in an autosomal recessive pattern, meaning that for the phenotype to appear, two copies of the gene must be present in the genotype. Most often, the parents of an individual with an autosomal recessive disorder are carriers of one copy of the altered gene but do not show signs and symptoms of the disorder. Tangier disease results in familial high-density lipoprotein deficiency. High-density lipoproteins are created when a protein in the bloodstream, Apolipoprotein A1 (apoA1), combines with cholesterol and phospholipids. The cholesterol and phospholipids used to form HDL originate from inside cells but are transported out of the cell
Tangier disease
91175
transition is a rate-limiting step in the cell cycle and is also known as restriction point. This is where the cell checks whether it has enough raw materials to fully replicate its DNA (nucleotide bases, DNA synthase, chromatin, etc.). An unhealthy or malnourished cell will get stuck at this checkpoint. The G/M checkpoint is where the cell ensures that it has enough cytoplasm and phospholipids for two daughter cells. But sometimes more importantly, it checks to see if it is the right time to replicate. There are some situations where many cells need to all replicate simultaneously (for example, a
Cell cycle
16836122
apoptotic cells in order to attract phagocytes (mostly macrophages and immature dendritic cells). Thanks to these markers, apoptotic cells, unlike necrotic cells, do not trigger the unwanted immune response. Eat-me signals mark the apoptotic cells for phagocytes which can subsequently engulf them and actively prevent the inflammation. Various molecular markers can serve as eat-me signals, particularly a change in composition of the cell membrane, modifications of molecules on the cell surface, changed charge on the plasma membrane, or indirectly the extracellular bridging molecules. Deposition of different phospholipids in the phospholipid bilayer of the cell membrane is strictly asymmetric. On a
ACAMPs
6729876
the melB gene of "E. coli". This strain of beta-galactoside permease is known it transport melibiose and other galactosides across the cell membrane using hydrogen, sodium, or lithium ions in cotransport. Early studies by Hiroshi in 1962 suggest a direct relationship between the amount of beta-galactoside permease activity in a cell and the turnover rate of phospholipids in "E. coli". In his experiments with gram-positive and gram-negative bacterial cells under varying conditions, the level of P in phospholipids was found to be increased under conditions of maximal activity in beta-galactoside permease. Insofar, Nikaido concluded that this correlation suggested that phospholipids
Beta-galactoside permease
15907487
a variety of mechanisms: The cell membrane consists of three classes of amphipathic lipids: phospholipids, glycolipids, and sterols. The amount of each depends upon the type of cell, but in the majority of cases phospholipids are the most abundant, often contributing for over 50% of all lipids in plasma membranes. Glycolipids only account for a minute amount of about 2% and sterols make up the rest. In RBC studies, 30% of the plasma membrane is lipid. However, for the majority of eukaryotic cells, the composition of plasma membranes is about half lipids and half proteins by weight. The fatty chains
Cell membrane
766119
red blood cell cell membrane comprises a typical lipid bilayer, similar to what can be found in virtually all human cells. Simply put, this lipid bilayer is composed of cholesterol and phospholipids in equal proportions by weight. The lipid composition is important as it defines many physical properties such as membrane permeability and fluidity. Additionally, the activity of many membrane proteins is regulated by interactions with lipids in the bilayer. Unlike cholesterol, which is evenly distributed between the inner and outer leaflets, the 5 major phospholipids are asymmetrically disposed, as shown below: Outer monolayer Inner monolayer This asymmetric phospholipid distribution
Red blood cell
12207063
in Essentiale medications) is a complex of substances of natural origin (ethers of cholinephosphoric acid (phosphatidylcholine) and unsaturated fatty acids (linoleic, linolenic, olein). Essentiale medications possess membranotropic properties, exert metabolic and hepatoprotective action, and regulate lipid and carbohydrate metabolism. Essential phospholipids increase the functional status of the liver. Intervening in the disturbance of the liver's metabolism, Essential phospholipids enter the cell membrane and combine with the endogenous phospholipids. Essential phospholipids improve the patient's clinical status and the liver's lab indices. Combination of Essentiale with cordiamin (nikethamide) and vitamin E (50 mg/kg for 35 days) considerably activates the mono-oxygenase, glucoro- and
Essentiale
4233497
of the cell plasma membrane that modulates cell signal transduction events, and appears to concentrate in lipid rafts. Recently, gangliosides have been found to be highly important molecules in immunology. Natural and semisynthetic gangliosides are considered possible therapeutics for neurodegenerative disorders. Gangliosides are present and concentrated on cell surfaces, with the two hydrocarbon chains of the ceramide moiety embedded in the plasma membrane and the oligosaccharides located on the extracellular surface, where they present points of recognition for extracellular molecules or surfaces of neighboring cells. They are found predominantly in the nervous system where they constitute 6% of all phospholipids.
Ganglioside
7601358
Keep yourself hydrated and wear appropriate clothing and footwear. Carry enough snacks and water with you, dining opportunities are extremely limited along the Longleaf Trace. Carry a cell phone and/or let someone know when you should be back from your outing. When passing others on the trail, call out to be sure that those ahead of you know that you are passing them. DO NOT Touch or Harass livestock, horses, or wild animals you find on or along the Longleaf Trace. DO NOT Enter private property from the Longleaf Trace without permission. Longleaf Trace The Longleaf Trace is a paved
Longleaf Trace
15907510
form the basis of the membranes do indeed form two-dimensional liquids by themselves, the plasma membrane also contains a large quantity of proteins, which provide more structure. Examples of such structures are protein-protein complexes, pickets and fences formed by the actin-based cytoskeleton, and potentially lipid rafts. Lipid bilayers form through the process of self-assembly. The cell membrane consists primarily of a thin layer of amphipathic phospholipids that spontaneously arrange so that the hydrophobic "tail" regions are isolated from the surrounding water while the hydrophilic "head" regions interact with the intracellular (cytosolic) and extracellular faces of the resulting bilayer. This forms
Cell membrane
324120
hydrophobic and avoid interactions with water. When placed in aqueous solutions, phospholipids are driven by hydrophobic interactions that result in the fatty acid tails aggregating to minimize interactions with water molecules. These specific properties allow phospholipids to play an important role in the phospholipid bilayer. In biological systems, the phospholipids often occur with other molecules (e.g., proteins, glycolipids, sterols) in a bilayer such as a cell membrane. Lipid bilayers occur when hydrophobic tails line up against one another, forming a membrane of hydrophilic heads on both sides facing the water. Such movement can be described by the fluid mosaic model,
Phospholipid
4346983
Lupus anticoagulant Lupus anticoagulant (also known as lupus antibody, LA, LAC, or lupus inhibitors) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Lupus anticoagulant is a misnomer, as it is actually a prothrombotic agent. Lupus anticoagulant antibodies in living systems cause an increase in inappropriate blood clotting. The name derives from their properties in vitro, as these antibodies increase laboratory coagulation tests such as the aPTT. Investigators speculate that the antibodies interfere with phospholipids used to induce in vitro coagulation. In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion
Lupus anticoagulant
5511871
annexin types, annexin A-V can also be expressed on the cell surface and can function to form 2-dimensional crystals to protect the lipids of the cell membrane from involvement in coagulation mechanisms. Medically speaking, phospholipids can often be recruited in autoimmune responses, most commonly observed in cases of fetal loss during pregnancy. In such cases, antibodies against annexin A-V destroy its 2-dimensional crystal structure and uncover the phospholipids in the membrane, making them available for contribution to various coagulation mechanisms. While several annexins may be involved in mechanisms of fibrinolysis, annexin A-II is the most prominent in mediating these responses.
Annexin
7467630
Phospholipid scramblase Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Scramblases are not members of the general family of transmembrane lipid transporters known as flippases. Scramblases are distinct from flippases and floppases. Scramblases, flippases, and floppases are three different types of enzymatic groups of phospholipid transportation enzymes. The inner-leaflet, facing the inside of the cell, contains negatively charged amino-phospholipids and phosphatidylethanolamine. The outer-leaflet, facing the outside environment, contains phosphatidylcholine
Phospholipid scramblase
15912795
the children because they know the place where the sidewalk ends. Looking more in depth at this poem makes clear what Shel Silverstein is saying. Do what the children do. They know the place where the sidewalk ends. And in doing so, you will find the joy and passion for life that they have. When he says to follow the markings of the children and you will find the place where the sidewalk ends, it is not a literal command to physically follow them. Rather he is saying put on the mindset of a child and you will, in turn,
Where the Sidewalk Ends (poem)
10188756
or the sn-2 position. The prefix 'lyso-' comes from the fact that lysophospholipids were originally found to be hemolytic, however it is now used to refer generally to phospholipids missing an acyl chain. LPLs are usually the result of phospholipase A-type enzymatic activity on regular phospholipids such as phosphatidylcholine or phosphatidic acid, although they can also be generated by the acylation of glycerophospholipids or the phosphorylation of monoacylglycerols. Some LPLs serve important signaling functions such as lysophosphatidic acid. LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell
Lysophospholipid receptor
10672812
an overall narrative of what it means to find the right beginning. Or, to let it find us. “When you start something you don’t know where it’s going to go,” Buddy says. “The whole record felt like solid footing right away. It wasn’t anguished over. We just did what we both do. I needed to feel scared and not know where it was going. I had to learn to just let it happen and let it keep unfolding. When you do that, suddenly you have these songs and they all go together.” Author: Emily Zemler "Last Call For The Quiet
Buddy (band)
238112
the extracellular face of the cell membrane after the inactivation of flippases which place them exclusively on the cytosolic side and the activation of scramblases, which scramble the orientation of the phospholipids. After this occurs, other cells recognize the phosphatidylserines and phagocytosize the cells or cell fragments exposing them. The "fat-soluble" vitamins (A, D, E and K) – which are isoprene-based lipids – are essential nutrients stored in the liver and fatty tissues, with a diverse range of functions. Acyl-carnitines are involved in the transport and metabolism of fatty acids in and out of mitochondria, where they undergo beta oxidation.
Lipid
15739193
make peace...? What journey he will go through...? What will he, or the whole family will discover...? It is a journey of a family...you may be surprised to find yourself there. Every person has an emotional journey with their family and all relationships around. All emotions are universal but yet each one of us has a personal experience. A personal point of view looking at moments…moments which can stir every cell in your body…moments that can take you deep into feelings…feelings you do not dare to think. Through this film I invite all of you to explore with me …Is
Khushiyaan
5092412
IL-13 leads to increased of expression of 15-lipoxygenase (15-LO-1), which is an enzyme involved in the breakdown of unsaturated fatty acids. 15-lipoxygenase acts by binding to phospholipids and yields hydroperoxy and epoxy metabolites. One such metabolite, 15-hydroxyeicosatetranoic acid (15-HETE), is released intracellularly, where it conjugates to phosphatidylethanolamine, a phospholipid component. 15-HETE-PE induces expression of the mucin MUC5AC. Goblet cell carcinoids are a class of rare tumors that form as a result of an excessive proliferation of both goblet and neuroendocrine cells. The majority of these tumors arise in the appendix and may present symptoms similar to the much more common
Goblet cell
11818672
construction and manufacturing enter in – how do the phases flow together. Money – where do you conserve, where do you splash to make a statement? You have to think wind loads – many sorts of stress – structural, seismic and personal. All the while you must stay aware of the human experience you are creating." Those interested in further exploring Fentress' unique perceptions on architecture will find his Seven Touchstones of Design published in the book "Architecture in the Public Interest" Edizioni Press. See also Further Reading below. Perhaps Fentress's most noted observation on public architecture is the following:
Curtis W. Fentress
18214564
– It's You! – And if I'm gone? – You will be always. – But I'm sick? – You can not hurt, can only hurt your shell. – But, I'm in it? – The shells of many, infinite in number, and you all at the same time! – But where are they, how do you find them? – They and center! – They can be seen? – They can feel ... – I love you! – Do you feel! – Do you love me? – I feel! Moses Over the grave of Olesya Semerni eternal memory is a cross, made
Oles Semernya
10756135
each carry one copy of the altered gene but do not show signs and symptoms of the disorder. Mutations in the "PLA2G6" gene have been identified in most individuals with infantile neuroaxonal dystrophy. The "PLA2G6" gene provides instructions for making an enzyme called an A2 phospholipase. This enzyme family is involved in metabolizing phospholipids. Phospholipid metabolism is important for many body processes, including helping to keep the cell membrane intact and functioning properly. Specifically, the A2 phospholipase produced from the "PLA2G6" gene, sometimes called PLA2 group VI, helps to regulate the levels of a compound called phosphatidylcholine, which is abundant
Infantile neuroaxonal dystrophy
8402024
when you come into our schools to speak of legality, justice, respect for the law, of civil co-existence, our youth will listen to you and follow you, but when these youngsters come of age and look for work, a house, economic and health assistance, where do they find them? With you or with us? Inspector, they find them with us. And, only with us. You’re Sicilian, and you know very well it’s like this. Why should I cooperate, eh? Just so you can arrest another dozen fathers of families or to let you find a few rusty pistols. What would
Pietro Aglieri
7831412
passed by a cultivated place which is near Homs—about four miles—at the end of the night. When the monk who was in the cell heard our speech, he came up to us and said: 'Who are you all?' We said: 'People from Damascus, coming from the land of the Byzantines.' He said: 'Do you know Abu Muslim al-Khawlani?' We said: 'Yes.' He said: 'When you come to him, greet him with the peace, and inform him that we find him in the Holy Books as a companion of Jesus son of Mary'." It appears that the Christian monk sees a
Abu Muslim al-Khawlani
16242470
themselves united by blood ties. When life itself becomes unbearable. Where destinies are based, for better or for worse? Where finally no, you do not laugh when you do not see yourself in the mirror... The story that the characters will be involved has an international dimension. Involuntarily, they will find themselves immersed in a conflict that is between the French intelligence services and their German rivals, in this case represented by a secret society: The Holy Vehm. French and Germans will try to capture the terrible secret of the Veil of Kali. Very soon they will find that it
Maléfices
43634
cell's primary machinery. There are also other kinds of biomolecules in cells. This article lists these primary cellular components, then briefly describes their function. The cell membrane, or plasma membrane, is a biological membrane that surrounds the cytoplasm of a cell. In animals, the plasma membrane is the outer boundary of the cell, while in plants and prokaryotes it is usually covered by a cell wall. This membrane serves to separate and protect a cell from its surrounding environment and is made mostly from a double layer of phospholipids, which are amphiphilic (partly hydrophobic and partly hydrophilic). Hence, the layer
Cell (biology)
11146243
and 15("S")-HETE bind to and activate the Leukotriene B4 receptor 2, activate the Peroxisome proliferator-activated receptor gamma, and at high concentrations cause cells to generate toxic reactive oxygen species; one or more of these effects may be at least in part responsible for their ability to promote inflammatory responses, alter the growth of various times of human cancer cell lines, contract various types of blood vessels, and stimulate pathological fibrosis in pulmonary arteries and liver (see 15-Hydroxyicosatetraenoic acid#15(S)-HpETE and 15(S)-HETE). 15("S")-HpETE and 15("S")-HETE are esterified into membrane phospholipids where they may be stored and subsequently released during cell stimulation. As
ALOX15
3984305
a next row first cell write =49-MATCH(10381232,B2:B50) and similarly Again use the references to cells instead of actual values. You should be presented with original ball numbers of 3,6,15,17,18,35. Now you can generate a fresh Lottery number combination from single =randbetween(1,combin(49,6)) or you could look at the list position numbers of earlier results to see if there is a trend. One could use the combinatorial number system to list or traverse all "k"-combinations of a given finite set, but this is a very inefficient way to do that. Indeed, given some "k"-combination it is much easier to find the next
Combinatorial number system
5148656
then I'll look all around,<br> And when I find Susanna, I'll fall upon the ground.<br> But if I do not find her, then surely about to die,<br> And when I'm dead and buried—Susanna, don't you cry.<br> Oh Susanna! Oh, don't you cry for me!<br> For I come from Alabama with a banjo on my knee<br> This version was sung exclusively in the 1942 "Merrie Melodies" short, "The Wacky Wabbit": Oh! Susanna, don't you cry for me!<br> I'm gonna get me lots of gold out on the Lone Prairie.<br> Gold is where you find it and when I find that stuff,<br>
Oh! Susanna
13098160
Paul before they talked on that fateful day. They find out that this encounter was stranger than it seemed as everything he told Reuben about his life was in fact true. They come to the same question that Paul left both of them: “Do you need everything you have?” There are three other characters in this scene: a man, a woman and a man on the phone. They seem to almost be reacting to the events of Reuben's life. The man and woman are fighting about the man cheating on her and the man on the cell phone is talking
Patience (play)
2802494
is abundant in sugar beets for example). Phosphatidylcholine occurs in all cellular organisms, being one of the major components of the phospholipid portion of the cell membrane. Commercial lecithin, as used by food manufacturers, is a mixture of phospholipids in oil. The lecithin can be obtained by water degumming the extracted oil of seeds. It is a mixture of various phospholipids, and the composition depends on the origin of the lecithin. A major source of lecithin is soybean oil. Because of the EU requirement to declare additions of allergens in foods, in addition to regulations regarding genetically modified crops, a
Lecithin
1692231
phospholipids (consisting of a phosphate head and two fatty acid tails) arranged into a double layer, the phospholipid bilayer is a semipermeable membrane that is very specific in its permeability. The hydrophilic phosphate heads are in the outside layer and exposed to the water content outside and within the cell. The hydrophobic tails are the layer hidden in the inside of the membrane. The phospholipid bilayer is most permeable to small, uncharged solutes. Protein channels float through the phospholipids, and, collectively, this model is known as the fluid mosaic model. The diffusion of water through a selectively permeable membrane is
Semipermeable membrane
7158989
out of the building. The employees play games to pass the time, including "Desert Island Picks" and "Who Would You Do?" When Ryan reveals that he is attending business school at night, Michael becomes enamored of his newfound protégé. Dwight becomes noticeably jealous of Ryan's favor with Michael, and he is seen sulking in his car to the tune "Everybody Hurts" by R.E.M. When Michael mentions that he left his cell phone in the office, Dwight rushes back into the building to fetch it. Michael asks Ryan to call his cell phone to help Dwight find it. The phone rings,
The Fire (The Office)
2976406
often a capsule of polysaccharides. The capsule helps the bacterium evade host phagocytosis. In laboratory culture, the S-layer and capsule are often lost by reductive evolution (the loss of a trait in absence of positive selection). Unlike the gram-positive cell wall, the gram-negative cell wall contains a thin peptidoglycan layer adjacent to the cytoplasmic membrane, which is responsible for the cell wall's inability to retain the crystal violet stain upon decolourisation with ethanol during Gram staining. In addition to the peptidoglycan layer the gram-negative cell wall also contains an additional outer membrane composed by phospholipids and lipopolysaccharides which face into
Cell envelope
9247927
enhance coagulation by inhibiting the function of tissue factor pathway inhibitor. Lp(a) carries cholesterol and binds atherogenic proinflammatory oxidized phospholipids as a preferential carrier of oxidized phospholipids in human plasma, which attract inflammatory cells to vessel walls and leads to smooth muscle cell proliferation. Moreover, Lp(a) also is hypothesized to be involved in wound healing and tissue repair, interacting with components of the vascular wall and extra cellular matrix. Apo(a), a distinct feature of the Lp(a) particle, binds to immobilized fibronectin and endows Lp(a) with the serine-proteinase-type proteolytic activity. Nonetheless, individuals without Lp(a) or with very low Lp(a) levels seem
Lipoprotein(a)
4414012
with a solution of sodium cyclopentadienide in THF. Aqueous solutions of manganese(II) chloride are used in P-NMR to determine the size and lamellarity of phospholipid vesicles. When manganese chloride is added to a vesicular solution, Mn paramagnetic ions are released, perturbing the relaxation time of the phospholipids' phosphate groups and broadening the resulting P resonance signal. Only phospholipids located in the outermost monolayer exposed to Mn experience this broadening. The effect is negligible for multilamellar vesicles, but for large unilamellar vesicles, a ~50% reduction in signal intensity is observed. Manganese chloride is mainly used in the production of dry cell
Manganese(II) chloride
6542342
SCD-1 deficiency has also been shown to reduce ceramide synthesis by downregulating serine palmitoyltransferase. This consequently increases the rate of beta-oxidation in skeletal muscle. In carbohydrate metabolism studies, knockout SCD-1 mice show increased insulin sensitivity. Oleate is a major constituent of membrane phospholipids and membrane fluidity is influenced by the ratio of saturated to monounsaturated fatty acids. One proposed mechanism is that an increase in cell membrane fluidity, consisting largely of lipid, activates the insulin receptor. A decrease in MUFA content of the membrane phospholipids in the SCD-1 mice is offset by an increase in polyunsaturated fatty acids, effectively increasing
Stearoyl-CoA desaturase-1
15997590
judgement, for my interrogators said you are their puppet and will do whatever they tell you to do. I hope God will reveal you the truth, so that God forbid, you will not be held accountable for what others have asked you do for them in another world. In the end, I reject all charges against me and ask you to find me not guilty. Mohammad Ghorbani"bidad"`s instagram page Arya Aramnejad Arya Aramnejad is an Iranian singer from Babol in the northern part of Iran. He became famous for his song "Ali Barkhiz" where he denounces the Islamic regime's crimes
Arya Aramnejad
15907506
groups, Archaea and Bacteria, with bacteria dividing further into gram-positive and gram-negative. Gram-negative bacteria have both a plasma membrane and an outer membrane separated by periplasm, however, other prokaryotes have only a plasma membrane. These two membranes differ in many aspects. The outer membrane of the gram-negative bacteria differ from other prokaryotes due to phospholipids forming the exterior of the bilayer, and lipoproteins and phospholipids forming the interior. The outer membrane typically has a porous quality due to its presence of membrane proteins, such as gram-negative porins, which are pore-forming proteins. The inner, plasma membrane is also generally symmetric whereas
Cell membrane
15724227
Choline/ethanolamine kinase family In molecular biology, the choline/ethanolamine kinase family includes choline kinase() and ethanolamine kinase (). Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the glycosylphosphatidylinositol (GPI) anchor, which is necessary for cell-surface protein attachment. The de novo synthesis of these phospholipids begins with the creation of phosphoethanolamine and phosphocholine by ethanolamine and choline kinases in the first step of the CDP-ethanolamine pathway. There are two putative choline/ethanolamine kinases (C/EKs) in the "Trypanosoma brucei" genome. Ethanolamine kinase has no choline kinase activity and its activity is inhibited
Choline/ethanolamine kinase family
11562688
clotrimazole. Clotrimazole works by inhibiting the growth of individual "Candida" or fungal cells by altering the permeability of the fungal cell wall. It binds to phospholipids in the cell membrane and inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production. Clotrimazole may be fungistatic (slow fungal growth) or fungicidal (result in fungal cell death). It is available as a generic medication. The wholesale cost in the developing world as of 2014 is 0.20–0.86 USD per 20gm tube of cream. In the United States a course of treatment typically costs less than 25 USD. In 2016 Canesten
Clotrimazole
15724228
by ADP. Inositol supplementation represses ethanolamine kinase, decreasing the incorporation of ethanolamine into the CDP-ethanolamine pathway and into phosphatidylethanolamine and phosphatidylcholine. Choline/ethanolamine kinase family In molecular biology, the choline/ethanolamine kinase family includes choline kinase() and ethanolamine kinase (). Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the glycosylphosphatidylinositol (GPI) anchor, which is necessary for cell-surface protein attachment. The de novo synthesis of these phospholipids begins with the creation of phosphoethanolamine and phosphocholine by ethanolamine and choline kinases in the first step of the CDP-ethanolamine pathway. There are two
Choline/ethanolamine kinase family
13137917
the PAR and Crumbs complexes are localized along the apical membrane and the Scribble complex along the lateral membrane. Together with a group of signaling molecules called Rho GTPases, these polarity complexes can regulate vesicle transport and also control the localization of cytoplasmic proteins primarily by regulating the phosphorylation of phospholipids called phosphoinositides. Phosphoinositides serve as docking sites for proteins at the cell membrane, and their state of phosphorylation determines which proteins can bind. While many of the key polarity proteins are well conserved, different mechanisms exist to establish cell polarity in different cell types. Here, two main classes can
Cell polarity
13635123
pregnancies, so it has been suggested that the higher frequency of some conditions in egg donation may be caused by reduced immune tolerance from the mother. Immunological responses could be the cause in many cases of infertility and miscarriage. Some immunological reasons that contribute to infertility are reproductive autoimmune failure syndrome, the presence of anti-phospholipid antibodies, and antinuclear antibodies. Anti-phospholipid antibodies are targeted toward the phospholipids of the cell membrane. Studies have shown that antibodies against phosphatidylserine, phoshphatidylcholine, phosphatidylglycerol, phosphatidylinositol and phosphatidylethanolamine target the pre-embryo. Antibodies against phosphatidylserine and phosphatidylethanolamine are against the trophoblast. These phospholipids are essential in the
Immune tolerance in pregnancy
6259705
deceptive. I warn you fairly: you will find me vitriol in the house. You would do wiser to pay money down and see my back." The Laird takes his wife and children and leaves Scotland for New York, where Mrs Durie has a family estate. Mackellar remains behind, and tells the Master that he may have room and board at Durrisdeer, but he will not be permitted to contact the family or given any money. The Master furiously answers: "Inside of a week, without leaving Durrisdeer, I will find out where these fools are fled to. I will follow; and
The Master of Ballantrae
8895786
grand,<br> Queen of all, she is my motherland. Sun, moon, planets, and stars aglow,<br> Where else with such a vibrant flow?<br> Where does lightning dance in clouds so dark and deep?<br> (Her) birdsong wakes me up, after lulling me to sleep.<br> Nowhere will you find a nation so grand,<br> Queen of all, she is my motherland. Who has such cool rivers?<br> Where are such smoky mountains?<br> Where do such lush green fields meet under the sky?<br> Where does the wind make such waves on rice-fields and blow by?<br> Nowhere will you find a nation so grand,<br> Queen of all, she
Dwijendralal Ray
4376947
Def Jam anyway, I just need to find another distributor. I might just have Cash Money do everything. Who knows? That's the beauty about being in the business for yourself. You can decide where you want to go and what you want to do. Although he blamed Def Jam CEO L.A. Reid for his frustration, later that month Shyne issued an apology. In November 2010, Birdman said that Shyne's deportation had stalled his Cash Money deal, as it would prevent him from appearing in the US. In November 2010, Shyne was living in Jerusalem, where he underwent a formal conversion
Shyne
4223019
organ, she first registers it, or memorizes where all of the stops are. She explained, "The first thing I do when I sit down at a new organ is just register it. I don't actually play that much because it's very important to know, first of all, where everything is. I don't present a lot of things. It's just something I've had to do, and I find whether you have a little time or a lot, you tend to take the time you have." While it can be a challenge to play different organs, it is also rewarding to figure
Diane Bish
13360365
"Get busy living or get busy dying. If you were to die in 24 hours are you then living life the way you find meaningful? If not what are you willing to do to change it? Your life is not going to improve until you do". She pursued higher education at the same time as ocean sailing and climbing tours. At the age of 20, after finishing college, she sailed the Caribbean working as a deck hand and later crossed the Atlantic on a yacht via the Azores. In 1982, she attended the University of Copenhagen where she achieved a
Lene Gammelgaard
19217225
from outside of self. To find opportunities, we need to be tuned in to the source. Every man's work is a signature of his life. What you do determines who you are and where you are going. What you do determines what you are known for, and what your family will become known for. Thoughts of greatness create a state of greatness. Achieving greatness without great ideas is difficult. People with a will to succeed, cultivate these thoughts and never give up because they know that they are destined to succeed.Like our ancestors, each of us has a choice as
Michel Ngue-Awane
4593785
function. Magnetotactic bacteria is a class of bacteria known to use magnetic fields for orientation. These bacteria demonstrate a behavioral phenomenon known as magnetotaxis which is how the bacterium orients itself and migrates in the direction along the Earth's magnetic field lines. The bacteria contain magnetosomes, which are nanometer-sized particles of magnetite or iron sulfide enclosed within the bacterial cells. The magnetosomes are surrounded by a membrane composed of phospholipids and fatty acids and contain at least 20 different proteins. Magnetosomes form in chains where the magnetic moments of each magnetosome align in parallel, causing each bacterium cell to essentially
Magnetoreception
1692233
in reverse osmosis are, in general, made out of polyamide, chosen primarily for its permeability to water and relative impermeability to various dissolved impurities including salt ions and other small molecules that cannot be filtered. Another example of a semipermeable membrane is dialysis tubing. The semipermeable membrane is pertinent to cellular communication. A cell membrane consists of proteins and phospholipids. Signaling molecules send chemical messages to the proteins in the cell membrane. The signaling molecules bind to proteins, which alters the protein. A message is sent into the cell and a specific cellular response is turned on or activated. Other
Semipermeable membrane
4994043
as mayonnaise. Lecithins are also present in brain and nerve tissue. There are many other phospholipids, some of which are glycolipids. The glycolipids include phosphatidyl sugars where the alcohol functional group is part of a carbohydrate. Phosphatidyl sugars are present in plants and certain microorganisms. A carbohydrate is very hydrophilic due to the large number of hydroxyl groups present. One of the main functions of glycerophospholipid is to serve as a structural component of biological membranes. Their amphipathic nature drives the formation of the lipid bilayer structure of membranes. The cell membrane seen under the electron microscope consists of two
Glycerophospholipid
4392095
or binding C4BP. The best characterized function of Protein S is its role in the anti coagulation pathway, where it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa. Only the free form has cofactor activity. Protein S can bind to negatively charged phospholipids via the carboxylated Gla domain. This property allows Protein S to function in the removal of cells which are undergoing apoptosis. Apoptosis is a form of cell death that is used by the body to remove unwanted or damaged cells from tissues. Cells, which are apoptotic (i.e. in the process
Protein S
710073
for a divorce, she betrays him to the authorities. He is offered a pardon if he will turn himself in; Allen accepts, only to find that it was just a ruse. He escapes once again. In the end, Allen visits Helen in the shadows on the street and tells her he is leaving forever. She asks, "Can't you tell me where you're going? Will you write? Do you need any money?" James repeatedly shakes his head in answer as he backs away. Finally, Helen says, "But you must, Jim. How do you live?" James' face is barely seen in the
I Am a Fugitive from a Chain Gang
17408222
for one of the major psychoses. Mabel's assistant, Ken Sadeghian, worked with her from the 1960s until her retirement. Interest in the PI effect waned in the 1960s and 1970s, but experienced a resurgence in the 1980s due to advances in technology and understanding of cell membrane biochemistry. Mabel and Lowell became regarded as founders of an important and still growing field of biochemistry and cell biology — the many roles of inositol phospholipids in cell function — for which they were honored at a 1996 symposium at the University of Wisconsin that gathered their colleagues from around the world.
Mabel Hokin
6182360
vitro", they grow as a monolayer; adherent or attaching to the culture flask. The cells are able to synthesize lecithin and contain high levels of unsaturated fatty acids, which are important to maintain membrane phospholipids. A549 cells are widely used as a type II pulmonary epithelial cell model for drug metabolism and as a transfection host. When grown for sufficient long time in cell culture, A549 cells may begin to differentiate, as signaled by the presence of multilamellar bodies. A549 cells have served as models of alveolar Type II pulmonary epithelium, finding utility in research examining the metabolic processing of
A549 cell
9564121
channels to enable better diffusion of nutrients. In natural environments, such as soil or the surfaces of plants, the majority of bacteria are bound to surfaces in biofilms. Biofilms are also important in medicine, as these structures are often present during chronic bacterial infections or in infections of implanted medical devices, and bacteria protected within biofilms are much harder to kill than individual isolated bacteria. The bacterial cell is surrounded by a cell membrane which is made primarily of phospholipids. This membrane encloses the contents of the cell and acts as a barrier to hold nutrients, proteins and other essential
Bacteria
17712603
is about them allowing me to shine, like I hope I allow them to do also." she added, "It's the great thing about being in a relationship where you know there's genuine love with a man who inspires me and challenges me, both intellectually and spiritually. I guess it is a tribute to him. When you do find someone you are on the same page with, it's a beautiful thing." In October, Arena promoted the single on "Sunrise" and "Dancing with the Stars". On October 21, 2013, Arena performed "You Set Fire to My Life" on "The X Factor" live
You Set Fire to My Life
9440
plant cell. The body tissues are composed of numerous types of cell, including those found in muscles, nerves and skin. Each typically has a cell membrane formed of phospholipids, cytoplasm and a nucleus. All of the different cells of an animal are derived from the embryonic germ layers. Those simpler invertebrates which are formed from two germ layers of ectoderm and endoderm are called diploblastic and the more developed animals whose structures and organs are formed from three germ layers are called triploblastic. All of a triploblastic animal's tissues and organs are derived from the three germ layers of the
Anatomy
17511407
Jeewanu Jeewanu (Sanskrit for "particles of life") are synthetic chemical particles that possess cell-like structure and seem to have some functional properties; that is, they are a model of primitive cells, or protocells. It was first synthesised by Krishna Bahadur (20 January 1926 — 5 August 1994), an Indian chemist and his team in 1963. Using photochemical reaction, they produced coacervates, microscopic cell-like spheres from a mixture of simple organic and inorganic compounds. Bahadur named these particles 'Jeewanu' because they exhibited some of the basic properties of a cell, such as the presence of semipermeable membrane, amino acids, phospholipids and
Jeewanu
13817013
his computer: "do you wanna know a secret?" The following night, a drunken Tina kisses Hank. Beth refuses to talk to him until the next night when he saves her from getting roofied at a nightclub. Beth goes outside the club for air, where she witnesses the boy who tried to drug her being murdered by someone in a mask. When the police arrive, they find "do you wanna know a secret?" is carved in the boy's back. An FBI agent (Jeff Conaway) tells the group not to leave the house, as they are all suspects for both murders. The
Do You Wanna Know a Secret?
4493382
Fatty acids (mainly in the form of triglycerides) are therefore the foremost storage form of fuel in most animals, and to a lesser extent in plants. In addition, fatty acids are important components of the phospholipids that form the phospholipid bilayers out of which all the membranes of the cell are constructed (the cell wall, and the membranes that enclose all the organelles within the cells, such as the nucleus, the mitochondria, endoplasmic reticulum, and the Golgi apparatus). Fatty acids can also be cleaved, or partially cleaved, from their chemical attachments in the cell membrane to form second messengers within
Fatty acid metabolism
4994044
identifiable layers, or "leaflets", each of which is made up of an ordered row of glycerophospholipid molecules. The composition of each layer can vary widely depending on the type of cell. Each glycerophospholipid molecule consists of a small polar head group and two long hydrophobic chains. In the cell membrane, the two layers of phospholipids are arranged as follows: This is a stable structure because the ionic hydrophilic head groups interact with the aqueous media inside and outside the cell, whereas the hydrophobic tails maximize hydrophobic interactions with each other and are kept away from the aqueous environments. The overall
Glycerophospholipid
1380581
with virtually its sole biosynthetic capability being the production of more phospholipids. The partitioning ability of the lipid bilayer is based on the fact that hydrophilic molecules cannot easily cross the hydrophobic bilayer core, as discussed in Transport across the bilayer below. The nucleus, mitochondria and chloroplasts have two lipid bilayers, while other sub-cellular structures are surrounded by a single lipid bilayer (such as the plasma membrane, endoplasmic reticula, Golgi apparatus and lysosomes). See Organelle. Prokaryotes have only one lipid bilayer- the cell membrane (also known as the plasma membrane). Many prokaryotes also have a cell wall, but the cell
Lipid bilayer
16355728
with a dislocated eye, and mutters "Maggie, I'll find you", before Negan repeatedly bludgeons Glenn's skull into a bloody pulp. In "The Cell", Negan's henchman Dwight leaves a picture of Glenn's mangled corpse in Daryl's cell, where he is being held captive, to torment him. In "Go Getters", Glenn and Abraham are shown to be buried together at Hilltop. In "The Other Side", Maggie remarks to Daryl that he hasn't spoken a word to her ever since he returned to the Hilltop. Crying, Daryl apologizes to Maggie for unintentionally causing Glenn's death. Maggie resolutely maintains Daryl wasn't to blame, saying
Glenn Rhee
13921791
mammalian cytochrome P450 enzymes convert 12("S")-HpETE to 12-oxo-ETE. 12-HETE (stereoisomer not determined), 12("S")-HETE, 12-oxo-ETE, hepoxilin B3, and trioxilin B3 are found in the "sn"-2 position of phospholipids isolated from normal human epidermis and human psoriatic scales. This indicates that the metabolites are acylated into the "sn"-2 position after being formed and/or directly produced by the metabolism of the arachidonic acid at the "sn"-2 position of these phospholipids. These acylation reactions may sequester and thereby inactivate or store the metabolites for release during cell stimulation. 12("S")-HETE and 12("R")-HETE are converted to 12-oxo-ETE by microsomal NAD+-dependent 12-hydroxyeicosanoid dehdrogenase in porcine polymophonuclear leukocytes;
12-Hydroxyeicosatetraenoic acid
6850314
design, using what's called biomimicry. Having a deep passion for biology and evolution, he tries to "find the principles in nature that makes products do what they look like they do". Stephenson's process progresses from sketch pad, to computer graphics, to clay models, and finally test models. He says the advantage of working with clay is that you can feel the transitions and feel where there is too much surface or more surface needed. He suggests that you could almost design a car blind, because "you don't have to see it, you have to feel it, and by feeling it
Frank Stephenson
3984303
0. Now the reverse engineering is a bit trickier. You could use 49 IF statements in one cell or use solver to find maximum argument for COMBIN result to be less or equal than position number. Instead let's use a table of 6 by 49 and use MATCH function where resulting row number would be the argument and a ball number. If you make column headings from 6 to 1 (B1:G1) in descending order and row labels of 1 to 49 (A2:A50) in ascending order (vertically ascending in Excel means numbers growing from top to bottom). Then if you fill
Combinatorial number system
11363840
the name "Hämosiderin" as hematological pigment. Legend of the stem cell-picture: Draft by Ernst Neumann himself, showing the "great-lymphozyt-stem-cell" (1912) or "great-lymphocyt" as stem cell for the postembryonic and embryonic development of erythropoiesis and leukopoiesis in the bone marrow and, as shown here, in the embryonic liver; GrLK: nucleus of great-lymphocyt-stem-cell; Erblk: Erythroblast; (Neumann 1914). Beside, you find the first announcement of the bone marrow as blood forming organ. Translation: "In the so-called red bone marrow of man as well as the rabbit, one can regularly find, in addition to the well known marrow cell, certain other elements which have
Franz Ernst Christian Neumann
12698323
doorway between the cell and where M2M are being filmed. Marit and Marion step through the doorway; when the appear in the cell they are in different blue clothes that match those of the young men. When the security personnel at the prison notice M2M they attempt to apprehend them, though M2M and the young men escape from the facility to where a black car is parked outside. Pursued by the security personnel, the car disappears through a liquid doorway in the road. When the doorway opens in a field, M2M and the young men are now in a white
Everything You Do
6514892
Profilin Profilin is an actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton. Profilin also binds sequences rich in the amino acid proline in diverse proteins. While most profilin in the cell is bound to actin, profilins have over 50 different binding partners. Many of those are related to actin regulation, but profilin also seems to be involved in activities in the nucleus such as mRNA splicing. Profilin binds some variants of membrane phospholipids (phosphatidylinositol (4,5)-bisphosphate and inositol trisphosphate). The function of this interaction is the sequestration of profilin in an "inactive" form, from where it
Profilin
7185887
so and so many years old (mentioning the exact age of his questioner), G-d asks him: Where are you? Are you aware of why you were created on this earth? Are you aware of what you are expected to do and how much you actually have done?" Chasidic lore tells that the Maggid of Mezeritch and the Baal Shem Tov came to visit Rabbi Shneur Zalman in prison. Although they had died, they came as souls within bodies. Rabbi Yosef Yitzchok Schneersohn is reputed to have once visited the cell (when he was in Saint Petersburg in the summer of
19 Kislev
1505413
from IU's law school in 1926, Carmichael moved to Florida, where he worked as a law clerk in a West Palm Beach legal firm, but he returned to Indiana in 1927 after failing the Florida bar exam. He joined an Indianapolis law firm (Bingham, Mendenhall and Bingham) and passed the Indiana bar, but devoted most of his energies to music. Carmichael had discovered his method of songwriting, which he described later: "You don't write melodies, you find them…If you find the beginning of a good song, and if your fingers do not stray, the melody should come out of hiding
Hoagy Carmichael
11316924
at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca/calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2. MARCKS has been shown to interact with TOB1 and with NMT2. MARCKS Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the "MARCKS" gene. It plays important roles in cell shape, cell motility, secretion, transmembrane transport, regulation of the cell cycle, and neural development. Recently, MARCKS has been implicated in the exocytosis of a number of
MARCKS
11317889
is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca, which suggests that this enzyme may function in a calcium-independent manner. PIK3C2B Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the "PIK3C2B" gene. The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal
PIK3C2B
18466097
have rest when they had a dream in which Shri Yalguresh said "You have become aged and old so where you are sleeping below Your head there is my murti take it and do its stapana and perform its puja" to Purohit. In the same way Sidhhanti also has the dream" You draw my photo on the wall and perform puja." They both wake up find the murti below the ground. Purohit took it home,did the stapana and performed its puja. Siddhanti Krishna draws a statue in home and performed its puja. Even today we can find the murti in
Yalagur