Hello doctor,I got bloodwork done for possible low T.My SHBG is higher, out of the normal range, even though the rest of my blood work is very good to excellent. My doctor told me that this is uncommon. I am curious as to how concerned I should be about this?
Hello,  Welcome to icliniq.com. I read your query and seen your lab reports. (attachment removed to protect patient identiy). Your report does suggest some concerning things such as high creatinine and low GFR (glomerular filtration rate), which suggest kidney dysfunction and a high SHBG (sex hormone binding globulin).  Increased SHBG levels may be seen in liver disease. I did not find any problem in your reports, but only with the knowledge about your health issues and with a proper medical history, I can find out if there is any underlying cause prevailing. Overactive thyroid: your thyroid test results are good and suggest a normal thyroid function. Eating disorders: I need more history from you to rule it out. Decreased sex hormone production in men: that aspect is good in the test results. So clearly it narrows down to your kidney function test which might be a possible reason here. Do you have any family history of kidney problems? Any Diabetes? Any excessive alcohol consumption or any over the counter medication intake? Answers to these questions could shed some light on the reason for high SHBG.  I hope this helps.