Hi doctor, My query is regarding the incompatibility of Quetiapine and Lamotrigine with other groups of drugs. Now I have to get treatment for an anaerobic infection. I was prescribed Azithromycin, Clindamycin, Metronidazole and Mycomax. However, I will be extremely grateful if you list me all groups of drugs incompatible with Quetiapine and Lamotrigine or just list the most important ones. Thank you.
Hello. As such for Lamotrigine following drug interactions need to be considered as important. For Quetiapine, Cytochrome P450 (CYP450) enzyme inhibitors reduces clearance of Quetiapine hence raises Quetiapine levels, therefore dosage needs to be reduced. May increase effect of antihypertensive agents. Besides these interactions no other major interactions with any other group of drugs.