Hi doctor, I am a 36 year old female. My height is 164 cm and weight is 48 kg. I was healthy with fine ligaments. Two years back, I had spine surgery for a herniated disk at the level of L5/S1. Soon after the operation, I got something like sleep myoclonus. The neurologist said that as benign, but I did not have anything like before. I am suffering from loose and weak ligaments in my spine and elsewhere. I am also having TMJ dysfunction, sacroiliac joint dysfunction, and ligament laxity. During anesthesia, I was given one dosage of Midazolam 2 mg, Propofol 200 mg, Cefazolin 2 mg, Atropine 1 mg, Fentanyl 0.3 mg, Rocuronium 40 mg, Neostigmine 2.5 mg, and Sevoflurane 63.05 mL. The operation duration was around 2 hours and 34 minutes. I do not have any drug allergy. But, I did not receive any inhaled anesthetics before. Does ligament laxity occur as a side effect of Sevoflurane?
Hi. I have read through your query in detail. Please find my observations below. Myoclonus or muscle twitching is a known side effect of Sevoflurane use, and it is not a serious concern. Sevoflurane does not cause laxity of ligaments. Very common side effects of Sevoflurane occurring in more than 10 % of patients are nausea, vomiting, hypotension, bradycardia, cough, and increased agitation. Common side effects occurring in 1 to 10 percent of patients are increased salivation, tachycardia, hypertension, laryngospasm, airway obstruction, breath holding, apnea, respiratory disorder, somnolence, dizziness, shivering, fever, hypothermia, headache, increased fluoride in blood, abnormal liver function test and abnormal blood glucose level. Uncommon side effects occurring in 0.1 to 1 % of patients are dry mouth, arrhythmia, ECG abnormalities, increased sputum, hypoxia, wheezing, bronchospasm, hyperventilation, pharyngitis, hiccup, hypoventilation, dyspnea, stridor, hypoxia, asthma, crying, nervousness, confusion, insomnia, confusional state, syncope, hypertonia, taste perversion, asthenia, pain, fluorosis, increase in AST (aspartate aminotransferase), increase in ALT (alanine transaminase), bilirubinemia, increase in LDH (lactate dehydrogenase), increase in alkaline phosphatase, hypophosphatemia, acidosis, hyperglycemia, increase in BUN (blood urea nitrogen), increase in creatinine, glycosuria, albuminuria, amblyopia, conjunctivitis, urination impaired, urine abnormality, urinary retention, oliguria, pruritus, and rash. Rare side effects occurring in less than 0.1 % of patients is malignant hyperthermia. Female hormones progesterone (before menstruation) and relaxin (during early pregnancy) cause joint hypermobility and ligament laxity. But, it is difficult to predict whether these factors are causing your symptoms or not. People with connective tissue disorder also might have laxity of joints.