Hello doctor, I have been tested for TPA by CLIA and a high titer of 451 was detected. But VDRL is nonreactive. There is a history of unprotected sex three years back with small erosions in genitalia. At that time broad medicines including antibiotics and antifungals were taken without any specific test. And remaining years were asymptomatic. Does it indicate latent syphilis? My wife also has similar test results now. If its latent form, how do we proceed with treatment?
Hello. 1. As you have mentioned the TPA (Treponema pallidum antibody assay) is positive. 2. VDRL is nonreactive.3. Next step to confirm if you have latent syphilis, you need to get one of the following two tests first. A.TPHA (Treponema pallidum Haemagglutination assay). Or B. TPPA ( Trepenoma pallium particle agglutination assay). A. TPPA/TPHA B. HIV C. HBsAg D. Anti HCV Please revert back with the investigations I have asked for so that I can decide on the specific treatment plan for you.