Hi doctor, My medical condition, background information, current lifestyle and medications are as follows: My cardiac calcium score was over 4,500 before four years and is now over 9,400. Angioplasty before six months revealed mid right coronary artery stenosis of less than 50% and diffused LAD 20%-30% but no focal stenosis visualized. It also shows large diagonal branch from proximal segment of LAD with stenosis of 60%-70%, left circumflex artery with 30% of stenosis at the ostium and 30%-40% of stenosis on its proximal segment and one large obtuse marginalo visualized without significant stenosis. RCA is large and dominant. In mid distal segment of RCA there is 70% stenosis. There is moderate degree of calcification in proximal RCA. Left ventriculogram showed estimated ejection fraction of 60%-65% with no significant wall motion abnormalities. During angioplasty interventionist was unable to place a stent and said RCA was like cement. Subsequent cardiac calcium scan revealed left main and LAD 1575, LCX 1276, RCA 6589. In pericardium there is no evidence of calcification or effusion. Enlargement of ascending aorta is 4.3 cm. I am asymptomatic. I use to do exercise daily and have a pretty good diet. I do have minor ischemia. I stopped taking calcium supplements after the angioplasty. I take 400 mg of Magnesium glycinate daily, 5000 IU of vitamin D about 4 times a week and 45 mcg of vitamin K2 daily. I use a transdermal Magnesium chloride spray (EASE) on the chest area daily. I am taking a variety of supplements including Omega 3, vitamin C, CLA, L-Camatine, Ubiquinol, Strontium for my senior osteoporosis, Pycnogenol, Mycophyto (combination of 6 mushrooms and garlic). I am also taking medications which include Plavix 75 mg daily, Verapamil ER 300 mg, Simcor 500/20 mg and Aspirin (enteric coated) 81 mg. I have been told by three cardiologists that calcification is irreversible and probably genetic. My questions are, Is cardiac calcification an irreversible condition? Does any significant (and accessible) studies prove that? Whether addition of crystallized Magnesium chloride is helpful for decalcification process? If so what are the other forms of magnesium can I take along with it? Whether oral chelation (EDTA supplements) is safe and effective in decalcification and recommended doses? Do Aspirin and/or Plavix block GLA and cause calcification? I am pleased for your recommendation.
Hi. I assure you not to worry as everything is going to be fine if proper care and treatment is opted in for. I have thoroughly gone through your case and can well understand your genuine health concerns. Cardiac calcification if not yet gone to the level of irreversible stage, can be reversed. But I want to add that we may prevent but not reverse the advanced calcification.  Lot of researches available on this topic, some in favor and some against this school of thought. Dr. Dean in her Book The Magnesium Miracle says "Crush a calcium pill and dissolve it in 1 oz of water, some portion will left over undissolved. Now take Magnesium pill, crush and slowly stir it in that water. Miraculously, undissolved calcium will start dissolve. Same happens inside human body".  Calcium and magnesium are important parts of the body and coronary vessels also have the same salts in it. Calcium if accumulated, Magnesium salts are used for dissolution of the calcium. Same is true with kidney calcium stones.  Muscle spasms, hardened vessels in cardiovascular system and even weaker bones and dental cavities can occur if you have less magnesium in the body. Magnesium pushes the calcium in bones and teeth and blood is cleared of the toxic effects of the calcium excess. Bone mineral density is actually under the control of magnesium, not calcium.  Very authentic studies have shown all the benefits of the magnesium usage for calcification reduction.  The level of your calcification and the triple vessel disease which you have all made the three cardiologists more justified to say it is irreversible. But let me add that it will stop it here (if not genetic predominant) and further calcification will be lowered. Yes, crystallized Magnesium chloride is beneficial. But should not mix it with other forms of Magnesium. This is a good salt and take it alone if prescribed. But you are already taking a good form and that is Glycinate.  Yes, EDTA (chelation) supplements are effective to some extent. They actually bind to the extra salts including calcium and chelates them and saves body from side effects and toxicities of overload (orally one capsule a day).  No they do not block Gamma-linolenic acid (GLA). There is not much research done and a little data available on this issue. But I usually say that whatever Aspirin/Plavix do to the GLA, they are inevitable and the benefits overweigh the risks. I need some answers, to assist you better.  1. Have you been prescribed Magnesium Chloride (crystallized) and EDTA supplements?  2. Which joints are mainly involved in osteoporosis?  3. What is your lipid profile levels?  4. Are you diabetic and taking medications? But I cannot see about it in the history.  5. How much remains your blood pressure?  6. Do you take some dietary fiber supplement?  7. How much water do you take daily?  In a follow up query, please do answer these. Revert back with answers to the above questions to a cardiologist online.--->