Hello doctor, I have studied that HLA-B35, HLA-B58, and HLA-B7 are responsible for the rapid progression of AIDS and often test false negative when tested. However, with C clade virus it is somewhat protective and does not lead to rapid disease progression which has something to do with the CD8 T cell response to a single gag epitope which is only available in the C clade virus. I want to know will an HLA-B35/58 person be infected with C clade virus and produce antibodies to HIV unlike in B clade virus? Also, what causes a false negative in B clade?
Hello. Best wishes. For more information consult an HIV AIDS specialist online -->