Hello doctor, My father has been a diabetic patient for the past 20 years. Six months ago, he got affected by pulmonary tuberculosis and got administered with anti-TB drugs and insulin was administered in basal bolus regimen. Now both TB and diabetes are well under control. For the past one week, he takes only two drugs for TB, namely Isokin 300 and Pyzina 750 for TB, apart from Glyciphage 500, Cardivas CR 40, Tazloc AM 80, and Minipress XL 5 mg tablets as advised by the doctor. But, for the past one month, I notice a change in his behavior. He has developed a sort of restlessness. He laughs childishly without caring about anything. He is developing an adamant attitude like for example, he took a huge quantity of food at one go, without heeding to our advice to eat slow and thereby a vomiting sensation developed. He is indifferent to everything now and seems to have no feeling of happiness, sadness, affection, or pain. He never listens to us and lives in his own world. This is more severe in the evenings and at night. His doctor mainly attributes this to stress and says he will be alright in due course when he entirely stops the TB drugs. Is this a side effect of the drugs or related to some other problem? Please advise.
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