Hello doctor, I am a hypertensive 31-year-old. ECG, TMT normal, echo normal except mild concentric LVH. On Telmisartan/ Amlodipine (80/5) at night and Amlodipine/Hydrochlorothiazide (5/12.5) in morning. HCTZ was started one month back but after monitoring Na, K are alright but uric acid is on the increasing trend. So, instead of HCTZ can I shift to Aldactone? I do feel I have slight (very mild) edema, maybe Amlodipine-induced edema as I am on 10 mg daily. Earlier, despite Telmisartan and Amlodipine, my BP was high but when HCTZ was added, it was working perfectly for me. My BP now is in the range of 120/80. So, I do not want to remove the diuretic. One of my medical friends suggested Aldactone may be introduced. It has no effect on uric acid, is that right? Kindly help me.
Hello. I agree with you that Hydrochlorothiazide increases uric acid levels, while Amlodipine may increase the leg swelling (peripheral edema). Coming to this point, Aldactone can be added to your therapy, but it has a weak antihypertensive effect and it may lead to high potassium levels. For this reason, it is important checking regularly potassium levels while taking Aldactone. If your blood pressure values remain still high while on Aldactone, I would recommend adding Moxonidine to your therapy. You should discuss with your doctor about the above treatment options. I remain at your disposal whenever you have any other questions. For more information consult a cardiologist online -->