Hi doctor,My wife's double marker test results are as below. Age 32 years old, hCGb - 53 ng/ml and Corr MOM 1.08, PAPP-P 653.6 mU/ml and Corr MOM 0.36, T21 - 1:224 age cut off 1:596 and cut off 1:250. What is the risk of Down's syndrome?
Hi. She is 32 years old. I do not have her complete gynecology, obstetrics, medical, previous family and drug history actually but at 32 years of age, the risk is not as much as elderly pregnant ladies at 40 years of age or above. So age-wise low risk as you have described report 1:596 means one in around 600 children will be affected. So least risk. For previous history in her and your family of Down's syndrome you have not mentioned actually but if it was significant (means if you had any relative with Down's syndrome) it should be mentioned them in the report as well. The biochemical risk they have mentioned one in 224 children in her laboratory report (attachment removed to protect patient identity) they made risk value. Normal cut off value for biochemical risk is one in 250 children actually below this doctors just have to describe petient that your risk is one in 224 children. But this risk is not all over for her it is just biochemical results in the laboratory that can have some fluctuations as well in results. All over her age, the previous history is not having any significant risk and biochemical markers also not very abnormal. It is better to have a scan around 13 weeks for nuchal translucency to have a more clear idea as this also need to check for Down syndrome for safe side. It is measurement 2.98 mm or below is normal. At 20 weeks better to have detailed anomaly scan with expertise hands and at 22 weeks better to check hearts and its flow tracts for develping baby via scan. In case of any abnormal symptoms like bleeding, pain or dizziness or palpitation report to the hospital. For more information consult an obstetrician and gynaecologist online -->