Hello doctor, Repeated IVF failure. I would just like an independent opinion, I am 34 years old and already had four failed IVF's. Not once was there a positive pregnancy test. I am healthy, gave birth to a healthy baby boy eight years back with my first husband who sadly passed on a few years ago. Remarried a few years later and have been struggling with infertility. Have been on numerous Clomid and IUI cycles with no success. Finally resorted to IVF and thought that after at least three attempts it would be successful as I had a good response to stimulation and good embryo production. The only issue was my husband's sperm morphology and viscosity. Fertilization was done via ICSI and was told that the blastocyst was top grade and perfect looking and already hatching. Is there any reason why the embryos are failing to implant. I am so frustrated, confused and depressed. The whole experience is emotionally and financially draining especially because I have no issues with my uterus, no hormonal issues, etc. My husband blames me, according to him, if the embryos were perfect looking than the problem surely is me. My clinic said I should come in and try again, however, I do not want to try again not knowing what the problem is or what can be done differently.
Hello. I completely empathize with you and understand your concerns here. The primary step where, in your case, things could have gone wrong is the stage of implantation over a non-receptive endometrium of the uterus when a top grade blastocyst is being transferred and each time there is a negative result. The implantation at endometrium is the issue in your case, most likely.  Few things are important for a good endometrium. The endometrial thickness should be more than 9 mm at ET. Good endometrial blood flow in zone 2, 3 and 4 to check for receptivity through transvaginal Doppler study in the mid-cycle before embryo transfer. Before even contemplating IVF, an endometrial biopsy for histopathology report should be obtained to rule out any pre-existent endometritis or and acid-fast bacillus (tuberculous cause). The malefactor is taken care of by ICSI and IVF and hence a high-grade blastocyst is being achieved for transfer. I would like you to share with me the last IVF cycle medicinal protocol, scans, follicular monitoring reports and if possible reports of endometrial biopsy for a histopathology, pap smear report, high vaginal swab culture (if any) for further study and check to ascertain what went wrong in your case.