Hello doctor, I have been diagnosed with catastrophic antiphospholipid syndrome before three years and had a brain stroke in the same month due to blood clots. Since then I have not encountered any blood clot and have been on Acitrom 5 mg, Ecosprin 75 mg and Azathioprine 100 mg. Three weeks back neurologist had replaced Azathioprine with HCQ 300. My ANA test was done before changing. ANA result was negative. Now for the last two days, I am experiencing pain near the heart line. The pain lasts for around one minute. Pain is such that it starts from deep inside and it pulls the skin/organs inwards. I have experienced such pain three to four times since two days. My query is, is this due to a change in medication? Whether HCQ be stopped and Azathioprine be restarted? What is the use of Azoran in APS and are these both drugs somewhat similar? Kindly guide as I am worried. Should I continue with HCQ and if not is Azoran safe in the long run? I am taking Azoran for more than 2.5 years.
Hello,  Welcome to icliniq.com. What treatment did you get during Catastrophic antiphospholipid syndrome? Was your APLA, LA test was positive? Azoran is an immunomodulatory drug and has some role in APLA syndrome. HCQS is a good drug for APLA as it has an anti-inflammatory plus anticoagulant effect but your symptoms started after three weeks of HCQS. Please try to consult your physician as he has examined you and he knows complete details. So he can guide that Azoran should be restarted or not? According to my opinion in your case, I think you should restart Azoran and stop HCQS.