Hello doctor, I am a 39-year-old female who is otherwise healthy. I recently had an MRI due to smelling smoke that is not there. Some white hyperintensities were found on the MRI. As a result, I had a lumbar puncture. Everything came back normal, no oligoclonal banging was present. However, my IgG synthesis rate appears abnormal. The values are IgG CSF 19.4 mg/dl, albumin CSF 69.2 mg/dl, IgG serum 453 mg/dl, albumin serum 2.3 g/dl and IgG CSF index 1.42.
Hello. The increase of protein (IgG and albumin) production in the LCS (liquide cerebro-spinal) could be related to different chronic neurological disorders like an autoimmune disorder, a chronic infection like Lyme disease, multiple sclerosis (MS), etc. Although the presence of oligoclonal bands has been excluded, MS cannot be excluded (in 20 % of the patients with MS, these bands are not present). As there is a presence of white matter changes, there is something wrong, and further investigations (blood and LCS laboratory tests) are needed to determine the diagnosis. I would like to directly review your brain MRI report for a more professional opinion. What is your medical history? For more information consult a neurologist online -->