###HUMAN: what are the numbers of patients who have had a diuretic - spironolactone two or more times?, ###ASSISTANT: SELECT COUNT(DISTINCT t1.uniquepid) FROM (SELECT patient.uniquepid, COUNT(*) AS c1 FROM patient WHERE patient.patientunitstayid = (SELECT treatment.patientunitstayid FROM treatment WHERE treatment.treatmentname = 'diuretic - spironolactone') GROUP BY patient.uniquepid) AS t1 WHERE t1.c1 >= 2