say that one of the steps in your gui automation program is to click gray button before calling the click(methodyou could take screenshot and look at the pixel where the script is about to click if it' not the same gray as the gray buttonthen your program knows something is wrong maybe the window moved unexpectedlyor maybe pop-up dialog has blocked the button at this pointinstead of continuing--and possibly wreaking havoc by clicking the wrong thing--your program can "seethat it isn' clicking the right thing and stop itself you can obtain the rgb color value of particular pixel on the screen with the pixel(function enter the following into the interactive shellimport pyautogui pyautogui pixel(( )( pyautogui pixel(( )( pass pixel( tuple of coordinateslike ( or ( )and it'll tell you the color of the pixel at those coordinates in your image the return value from pixel(is an rgb tuple of three integers for the amount of redgreenand blue in the pixel (there is no fourth value for alphabecause screenshot images are fully opaque pyautogui' pixelmatchescolor(function will return true if the pixel at the given xand -coordinates on the screen matches the given color the first and second arguments are integers for the xand -coordinatesand the third argument is tuple of three integers for the rgb color the screen pixel must match enter the following into the interactive shellimport pyautogui pyautogui pixel(( )( pyautogui pixelmatchescolor( ( )true pyautogui pixelmatchescolor( ( )false after using pixel(to get an rgb tuple for the color of pixel at specific coordinates upass the same coordinates and rgb tuple to pixelmatchescolor(vwhich should return true then change value in the rgb tuple and call pixelmatchescolor(again for the same coordinates this should return false this method can be useful to call whenever your gui automation programs are about to call click(note that the color at the given coordinates must exactly match if it is even slightly different--for example( instead of ( )--then pixelmatchescolor(will return false controlling the keyboard and mouse with gui automation