| 41–25 |- style="background:#cfc;" | 67 | March 11 | Charlotte | | James Harden (28) | Clint Capela (15) | James Harden (10) | Toyota Center18,055 | 42–25 |- style="background:#fcc;" | 68 | March 13 | Golden State | | James Harden (29) | Clint Capela (13) | James Harden (10) | Toyota Center18,122 | 42–26 |- style="background:#cfc;" | 69 | March 15 | Phoenix | | James Harden (41) | Clint Capela (11) | James Harden (11) | Toyota Center18,055 | 43–26 |- style="background:#cfc;" | 70 | March 17 | Minnesota | | Chris Paul (25) | Clint Capela (13) | Harden, Paul (10) | Toyota Center18,055 | 44–26 |- style="background:#cfc;" | 71 | March 19 | @ Atlanta | | James Harden (31) | Clint Capela (11) | Chris Paul (11) | State Farm Arena16,293 | 45–26 |- style="background:#fcc;" | 72 | March 20 | @ Memphis | | James Harden (57) | Clint Capela (10) | James Harden (8) | FedExForum16,691 | 45–27 |- style="background:#cfc;" | 73 | March 22 | San Antonio | | James Harden (61) | Clint Capela (16) | Chris Paul (5) | Toyota Center18,055 | 46–27 |- style="background:#cfc;" | 74 | March 24 | @ New Orleans | | James Harden (28) | Clint Capela (17) | Chris Paul (13) | Smoothie King Center17,048 | 47–27 |- style="background:#fcc;" | 75 | March 26 | @ Milwaukee | | James Harden (23) | Clint Capela (11) | James Harden (7) | Fiserv Forum17,910 | 47–28 |- style="background:#cfc;" | 76 | March 28 | Denver | | James Harden (38) | Clint Capela (15) | Chris Paul (8) | Toyota Center18,055 | 48–28 |- style="background:#cfc;" | 77 | March 30 | Sacramento | | James Harden (50) | Clint Capela (15) | James Harden (10) | Toyota Center18,055 | 49–28 |- style="background:#cfc;" | 78 | April 2 | @ Sacramento | | James Harden (36) | Clint Capela (13) | Chris Paul (12) | Golden 1 Center17,583 | 50–28 |- style="background:#cfc;" | 79 | April 3 | @ LA Clippers | | James Harden (31) | Clint Capela (15) | Harden, Paul (7) | Staples Center17,593 | 51–28 |- style="background:#cfc;" | 80 | April 5 | New York | | James Harden (26) | Clint Capela (15) | Chris Paul (10) | Toyota Center18,055 | 52–28 |- style="background:#cfc;" | 81 | April 7 | Phoenix | | James Harden (30) | Capela, Harden (13) | Paul, Harden (9) | Toyota Center18,055 | 53–28 |- style="background:#fcc;" | 82 | April 9 | @ Oklahoma City | | James Harden (39) | Capela, Harden (10) | Chris Paul (6) | Chesapeake Energy Arena18,203 | 53–29 Playoffs |- bgcolor=ccffcc | 1 | April 14 | Utah | | James Harden (29) | Clint Capela (12) | James Harden (10) | Toyota Center18,055 | 1–0 |- bgcolor=ccffcc | 2 | April 17 | Utah | | James Harden (32) | James Harden (13) | James Harden (10) | Toyota Center18,055 | 2–0 |- bgcolor=ccffcc | 3 | April 20 | @ Utah | | James Harden (22) | Clint Capela (14) | James Harden (10) | Vivint Smart Home Arena18,306 | 3–0 |- bgcolor=ffcccc | 4 | April 22 | @ Utah | | James Harden (30) | Chris Paul (8) | Chris Paul (7) | Vivint Smart Home Arena18,306 | 3–1 |- bgcolor=ccffcc | 5 | April 24 | Utah | | James Harden (26) | Clint Capela (10) | James Harden (6) | Toyota Center18,055 | 4–1 |- style="background:#fcc;" | 1 | April 28 |