@ LA Clippers | | James Harden (31) | Capela, Anthony (6) | James Harden (14) | Staples Center16,149 | 1–2 |- style="background:#fcc;" | 4 | October 24 | Utah | | James Harden (29) | Clint Capela (12) | James Harden (7) | Toyota Center18,055 | 1–3 |- style="background:#fcc;" | 5 | October 26 | LA Clippers | | Carmelo Anthony (24) | Clint Capela (15) | Chris Paul (8) | Toyota Center18,055 | 1–4 |- style="background:#fcc;" | 6 | October 30 | Portland | | Chris Paul (17) | Clint Capela (14) | Chris Paul (9) | Toyota Center18,055 | 1–5 |- style="background:#cfc;" | 7 | November 2 | @ Brooklyn | | Chris Paul (32) | Clint Capela (13) | Chris Paul (11) | Barclays Center14,013 | 2–5 |- style="background:#cfc;" | 8 | November 3 | @ Chicago | | James Harden (25) | Clint Capela (12) | Chris Paul (8) | United Center20,505 | 3–5 |- style="background:#cfc;" | 9 | November 5 | @ Indiana | | James Harden (28) | Clint Capela (10) | Chris Paul (13) | Bankers Life Fieldhouse14,735 | 4–5 |- style="background:#fcc;" | 10 | November 8 | @ Oklahoma City | | James Harden (19) | James Harden (8) | James Harden (5) | Chesapeake Energy Arena 18,203 | 4–6 |- style="background:#fcc;" | 11 | November 10 | @ San Antonio | | James Harden (25) | Clint Capela (17) | Chris Paul (4) | AT&T Center18,354 | 4–7 |- style="background:#cfc;" | 12 | November 11 | Indiana | | James Harden (40) | Gary Clark (8) | James Harden (9) | Toyota Center18,055 | 5–7 |- style="background:#cfc;" | 13 | November 13 | @ Denver | | Clint Capela (24) | Clint Capela (9) | James Harden (11) | Pepsi Center16,741 | 6–7 |- style="background:#cfc;" | 14 | November 15 | Golden State | | James Harden (27) | Clint Capela (10) | Chris Paul (7) | Toyota Center18,055 | 7–7 |- style="background:#cfc;" | 15 | November 17 | Sacramento | | James Harden (34) | Clint Capela (16) | Chris Paul (9) | Toyota Center18,055 | 8–7 |- style="background:#cfc;" | 16 | November 21 | Detroit | | James Harden (43) | Clint Capela (15) | James Harden (9) | Toyota Center18,055 | 9–7 |- style="background:#fcc;" | 17 | November 23 | @ Detroit | | James Harden (33) | Clint Capela (21) | Chris Paul (9) | Little Caesars Arena17,268 | 9–8 |- style="background:#fcc;" | 18 | November 24 | @ Cleveland | | James Harden (40) | Clint Capela (10) | James Harden (13) | Quicken Loans Arena19,432 | 9–9 |- style="background:#fcc;" | 19 | November 26 | @ Washington | | James Harden (54) | Clint Capela (14) | James Harden (13) | Capital One Arena16,872 | 9–10 |- style="background:#fcc;" | 20 | November 28 | Dallas | | James Harden (25) | James Harden (11) | James Harden (17) | Toyota Center18,055 | 9–11 |- style="background:#cfc;" | 21 | November 30 | @ San Antonio | | Clint Capela (27) | Clint Capela (12) | Harden, Paul (10) | AT&T Center18,354 | 10–11 |- style="background:#cfc;" | 22 | December 1 | Chicago | | James Harden (30) | Clint Capela (15) | Chris Paul (13) | Toyota Center18,055 | 11–11 |- style="background:#fcc;" | 23 | December 3 | @ Minnesota | | James Harden (29) | P. J. Tucker (9) | James Harden (8) | Target Center13,834 | 11–12 |- style="background:#fcc;" | 24 | December 6 | @ Utah | | James Harden (15) |