26–19 |- style="background:#fcc;" | 46 | January 21 | @ Philadelphia | | James Harden (37) | Harden, Tucker, Faried (6) | Harden, Rivers (3) | Wells Fargo Center20,313 | 26–20 |- style="background:#cfc;" | 47 | January 23 | @ New York | | James Harden (61) | James Harden (15) | Harden, Rivers (4) | Madison Square Garden18,819 | 27–20 |- style="background:#cfc;" | 48 | January 25 | Toronto | | James Harden (35) | Kenneth Faried (14) | James Harden (7) | Toyota Center18,055 | 28–20 |- style="background:#cfc;" | 49 | January 27 | Orlando | | James Harden (40) | James Harden (11) | Harden, Paul (6) | Toyota Center18,055 | 29–20 |- style="background:#fcc;" | 50 | January 29 | New Orleans | | James Harden (37) | Harden, Faried (11) | Chris Paul (9) | Toyota Center18,055 | 29–21 |- style="background:#fcc;" | 51 | February 1 | @ Denver | | James Harden (30) | Harden, Faried (6) | James Harden (9) | Pepsi Center20,106 | 29–22 |- style="background:#cfc;" | 52 | February 2 | @ Utah | | James Harden (43) | Harden, Faried (12) | James Harden (5) | Vivint Smart Home Arena18,306 | 30–22 |- style="background:#cfc;" | 53 | February 4 | @ Phoenix | | James Harden (44) | Kenneth Faried (14) | James Harden (6) | Talking Stick Resort Arena15,740 | 31–22 |- style="background:#cfc;" | 54 | February 6 | @ Sacramento | | James Harden (36) | Kenneth Faried (11) | Chris Paul (11) | Golden 1 Center17,583 | 32–22 |- style="background:#fcc;" | 55 | February 9 | Oklahoma City | | James Harden (42) | Kenneth Faried (12) | Chris Paul (9) | Toyota Center18,061 | 32–23 |- style="background:#cfc;" | 56 | February 11 | Dallas | | James Harden (31) | Harden, Faried (8) | Chris Paul (11) | Toyota Center18,055 | 33–23 |- style="background:#fcc;" | 57 | February 13 | @ Minnesota | | James Harden (42) | Kenneth Faried (11) | Chris Paul (8) | Target Center15,131 | 33–24 |- align="center" |colspan="9" bgcolor="#bbcaff"|All-Star Break |- style="background:#cfc;" |- style="background:#fcc;" | 58 | February 21 | @ LA Lakers | | James Harden (30) | Clint Capela (11) | Chris Paul (9) | Staples Center18,997 | 33–25 |- style="background:#cfc;" | 59 | February 23 | @ Golden State | | Eric Gordon (25) | Clint Capela (15) | Chris Paul (17) | Oracle Arena19,596 | 34–25 |- style="background:#cfc;" | 60 | February 25 | Atlanta | | James Harden (28) | Kenneth Faried (10) | Chris Paul (8) | Toyota Center18,055 | 35–25 |- style="background:#cfc;" | 61 | February 27 | @ Charlotte | | James Harden (30) | Clint Capela (17) | Chris Paul (8) | Spectrum Center17,903 | 36–25 |- style="background:#cfc;" | 62 | February 28 | Miami | | James Harden (58) | Clint Capela (11) | James Harden (10) | Toyota Center18,055 | 37–25 |- style="background:#cfc;" | 63 | March 3 | @ Boston | | James Harden (42) | Clint Capela (9) | Chris Paul (12) | TD Garden18,624 | 38–25 |- style="background:#cfc;" | 64 | March 5 | @ Toronto | | James Harden (35) | Clint Capela (15) | Chris Paul (10) | Scotiabank Arena19,800 | 39–25 |- style="background:#cfc;" | 65 | March 8 | Philadelphia | | James Harden (31) | James Harden (10) | Chris Paul (8) | Toyota Center18,055 | 40–25 |- style="background:#cfc;" | 66 | March 10 | @ Dallas | | James Harden (26) | Clint Capela (12) | Chris Paul (9) | American Airlines Center20,423