 Xenon <unk> robust <unk> and <unk> through a variety of mechanisms of action . Through its influence on Ca2 + , K + , <unk> \ <unk> and NMDA <unk> xenon is <unk> when administered before , during and after ischemic insults . Xenon is a high affinity antagonist at the NMDA receptor <unk> site . Xenon is <unk> in <unk> @-@ <unk> conditions by inducing <unk> non @-@ ischemic <unk> . Xenon is <unk> by activating <unk> @-@ <unk> & downstream <unk> @-@ <unk> . Xenon <unk> <unk> ischemic <unk> by activating ATP sensitive potassium channels . Xenon <unk> reduces ATP mediated channel activation <unk> independently of the <unk> <unk> <unk> , increasing <unk> open @-@ channel time and frequency . Xenon <unk> hypoxia <unk> factor 1 alpha ( <unk> ) . 
