 An important <unk> mechanism of <unk> in AML is the epigenetic induction of <unk> by genetic mutations that alter the function of epigenetic enzymes , such as the DNA <unk> <unk> and the metabolic enzymes <unk> and <unk> , which lead to the generation of a novel <unk> , D @-@ 2 @-@ <unk> , which inhibits the activity of epigenetic enzymes such as <unk> . The hypothesis is that such epigenetic mutations lead to the <unk> of tumor <unk> genes and / or the activation of proto @-@ <unk> . 
