 Corpus Christi Bay is a scenic semi @-@ tropical bay on the Texas coast found in San <unk> and Nueces counties , next to the major city of Corpus Christi . It is separated from the Gulf of Mexico by Mustang Island , and is fed by the Nueces River and Oso Creek from its western and southern extensions , Nueces Bay and Oso Bay . The bay is located approximately 136 miles ( 219 km ) south of San Antonio , and 179 miles ( 288 km ) southwest of Houston . 
