 Multinucleated cells contain multiple nuclei . Most <unk> species of <unk> and some fungi in <unk> have naturally multinucleated cells . Other examples include the intestinal parasites in the genus <unk> , which have two nuclei per cell . In humans , skeletal muscle cells , called <unk> and <unk> , become multinucleated during development ; the resulting arrangement of nuclei near the periphery of the cells allows <unk> intracellular space for <unk> . Multinucleated and <unk> cells can also be abnormal in humans ; for example , cells arising from the fusion of <unk> and macrophages , known as giant multinucleated cells , sometimes accompany inflammation and are also implicated in tumor formation . 
