 The clinical manifestations of Chagas disease are due to cell death in the target tissues that occurs during the infective cycle , by <unk> inducing an inflammatory response , cellular <unk> , and <unk> . For example , intracellular amastigotes destroy the <unk> neurons of the autonomic nervous system in the intestine and heart , leading to <unk> and heart <unk> , respectively . If left untreated , Chagas disease can be fatal , in most cases due to heart muscle damage . 
