 The first protein structures to be solved were <unk> and <unk> , by Max <unk> and Sir John <unk> <unk> , respectively , in 1958 . As of 2016 , the Protein Data Bank has over 115 @,@ 000 atomic @-@ resolution structures of proteins . In more recent times , <unk> @-@ electron microscopy of large <unk> assemblies and computational protein structure prediction of small protein domains are two methods approaching atomic resolution . 
