 Researchers are investigating the clinical significance of c @-@ KIT mutations in AML . These are prevalent , and potentially clinically relevant because of the availability of <unk> kinase inhibitors , such as <unk> and <unk> that can block the activity of c @-@ KIT <unk> . It is expected that additional markers ( e.g. , <unk> , <unk> , and <unk> ) that have consistently been associated with an inferior outcome will soon be included in these recommendations . The prognostic importance of other <unk> genes ( e.g. , <unk> , <unk> , <unk> ) is less clear . 
