 The M3 subtype of AML , also known as acute promyelocytic leukemia ( APL ) , is almost universally treated with the drug all @-@ trans @-@ <unk> acid ( <unk> ) in addition to induction chemotherapy , usually an anthracycline . Care must be taken to prevent disseminated <unk> <unk> ( <unk> ) , complicating the treatment of APL when the <unk> release the contents of their granules into the peripheral circulation . APL is eminently <unk> , with well @-@ documented treatment protocols . 
