 Antibodies to certain types of chromatin organization , in particular , <unk> , have been associated with a number of <unk> diseases , such as systemic lupus <unk> . These are known as anti @-@ nuclear antibodies ( ANA ) and have also been observed in concert with multiple <unk> as part of general immune system <unk> . As in the case of <unk> , the role played by the antibodies in inducing the symptoms of <unk> diseases is not obvious . 
