 In large burns ( over 30 % of the total body surface area ) , there is a significant inflammatory response . This results in increased leakage of fluid from the <unk> , and subsequent tissue <unk> . This causes overall blood volume loss , with the remaining blood suffering significant plasma loss , making the blood more concentrated . <unk> blood flow to organs such as the <unk> and gastrointestinal tract may result in renal failure and stomach <unk> . 
