 <unk> leukaemia bodies ( PML bodies ) are spherical bodies found scattered throughout the nucleoplasm , measuring around 0 @.@ 1 – 1 @.@ 0 µm . They are known by a number of other names , including nuclear domain 10 ( <unk> ) , <unk> bodies , and PML <unk> domains . PML bodies are named after one of their major components , the promyelocytic leukemia protein ( PML ) . They are often seen in the nucleus in association with Cajal bodies and cleavage bodies . PML bodies belong to the nuclear matrix , an ill @-@ defined super @-@ structure of the nucleus proposed to anchor and regulate many nuclear functions , including DNA replication , transcription , or epigenetic <unk> . The PML protein is the key organizer of these domains that recruits an ever @-@ growing number of proteins , whose only common known feature to date is their ability to be <unk> . Yet , <unk> / - mice ( which have their PML gene deleted ) cannot assemble nuclear bodies , develop normally and live well , demonstrating that PML bodies are <unk> for most basic biological functions . 
