 In the early 18th century , a tribal confederacy known as the Six Nations of the Iroquois , headquartered in New York , ruled the Indian ( Native American ) tribes of Pennsylvania , including those who lived near what would become Lock Haven . Indian settlements in the area included three Munsee villages on the 325 @-@ acre ( 1 @.@ 32 km2 ) Great Island in the West Branch Susquehanna River at the mouth of Bald Eagle Creek . Four Indian trails , the Great Island Path , the Great <unk> Path , the Bald Eagle Creek Path , and the <unk> Path , crossed the island , and a fifth , Logan 's Path , met Bald Eagle Creek Path a few miles upstream near the mouth of <unk> Creek . During the French and Indian War ( 1754 – 63 ) , colonial <unk> on the <unk> Expedition destroyed Munsee property on the Great Island and along the West Branch . By 1763 , the Munsee had abandoned their island villages and other villages in the area . 
