 Wilder 's colleague , paediatrician <unk> Peterman , later formulated the classic diet , with a ratio of one gram of protein per kilogram of body weight in children , 10 – 15 g of carbohydrate per day , and the remainder of calories from fat . Peterman 's work in the 1920s established the techniques for induction and maintenance of the diet . Peterman documented positive effects ( improved alertness , behaviour and sleep ) and adverse effects ( nausea and vomiting due to excess ketosis ) . The diet proved to be very successful in children : Peterman reported in 1925 that 95 % of 37 young patients had improved seizure control on the diet and 60 % became seizure @-@ free . By 1930 , the diet had also been studied in 100 teenagers and adults . Clifford <unk> , also from the Mayo Clinic , reported that 56 % of those older patients improved on the diet and 12 % became seizure @-@ free . Although the adult results are similar to modern studies of children , they did not compare as well to contemporary studies . <unk> concluded that adults were least likely to benefit from the diet , and the use of the ketogenic diet in adults was not studied again until 1999 . 
