 " Me Against the Music " was released as the lead single from In the Zone on October 20 , 2003 , by JIVE Records . The label 's choice for the first single was originally " Outrageous " , but Spears convinced them to release " Me Against the Music " . The song received mixed reviews from critics . Some felt it was a strong dance track of the album , while others referred to it as lackluster and disappointing . " Me Against the Music " achieved international success , peaking atop of the charts in countries such as Australia , Denmark , Hungary , Ireland and Spain , as well as the European Hot 100 Singles . It also peaked at number two in Canada , Italy , Norway and the United Kingdom , and inside the top five in many other nations . The song won the " Hot Dance Single of the Year " accolade at the 2004 Billboard Music Awards . In the song 's accompanying music video , Spears chases Madonna inside a nightclub . " Toxic " was released as the album 's second single on January 12 , 2004 . After trying to choose between " ( I Got That ) Boom Boom " and " Outrageous " , Spears selected " Toxic " instead . The song received positive reviews from critics . " Toxic " attained worldwide success , reaching the top @-@ five in fifteen countries , while topping the charts in Australia , Canada , Hungary , Norway and the United Kingdom . In the United States , it became her first single to peak inside the top ten in almost four years . The accompanying music video for the song portrays Spears as a secret agent in the search of a vial of green liquid . After she steals it , she enters an apartment and poisons her unfaithful boyfriend . The video also includes interspersed scenes of Spears naked with diamonds over her body . " Toxic " won Spears her first Grammy Award for Best Dance Recording , and its often referred to as one of her defining songs . 
