 Overall , Ohio is home to 21 @,@ 250 manufacturing operations . Cincinnati is ranked # 6 , Cleveland # 10 , and Columbus # 19 respectively in the nation for manufacturing jobs . Ohio leads the nation in general @-@ purpose machinery production and is # 2 in metalworking machinery production . In 2004 , Ohio was third in the nation for major industrial operations , and second in the nation for total manufacturing payroll . Ohio was third in the nation in manufacturing GDP in 2008 , but has lost 106 @,@ 629 manufacturing jobs and over 1 @,@ 000 manufacturers since 2007 . 
