 The Simpsons ' dog , Santa 's Little Helper becomes very excited and runs away from home to the dog racing track , where he falls in love with a female greyhound named She 's the Fastest . She is given to the Simpsons after her owner notes that she will no longer race after falling in love . One day , She 's the Fastest gives birth to 25 puppies . Eventually , the puppies become difficult to manage , and Homer and Marge Simpson attempt to sell them to people more capable of giving them adequate care . After seeing the puppies unwilling to separate , however , people begin to leave . Suddenly , Montgomery Burns arrives and offers to let them live in his mansion . After the Simpsons choose not to sell the puppies to him , he steals them when they are not looking . 
