 On 21 October 1805 Agamemnon fought in the Battle of Trafalgar . Agamemnon was positioned eighth in Nelson 's weather column , with Orion ahead and Minotaur astern . Once engaged , she was firing both batteries , eventually pounding the great Spanish four @-@ decker Santísima Trinidad until that ship was dismasted and , with 216 of her complement dead , struck her colours . Before Berry could take possession of the prize , the enemy van division began bearing down on the British line , having previously been cut off from the battle by Nelson 's line @-@ breaking tactics . With Nelson already dying below decks on Victory , Captain of the Fleet Thomas Hardy ordered Agamemnon and several other ships to intercept them . Three of the enemy ships broke off and ran for Cádiz ; after briefly engaging Intrépide the British ships moved to try to cut off the fleeing ships . Over the course of the battle , Agamemnon suffered just two fatalities , and eight men were wounded . 
