 It is traditionally believed that so @-@ called " deep " infections — such as osteomyelitis or infective endocarditis — should be treated with bactericidal antibiotics , not bacteriostatic ones . Nevertheless , preclinical studies were conducted to assess the efficacy of linezolid for these infections , and the drug has been used successfully to treat them in clinical practice . Linezolid appears to be a reasonable therapeutic option for infective endocarditis caused by multi @-@ resistant Gram @-@ positive bacteria , despite a lack of high @-@ quality evidence to support this use . Results in the treatment of <unk> endocarditis have varied , with some cases treated successfully and others not responding to therapy . <unk> to medium @-@ quality evidence is also mounting for its use in bone and joint infections , including chronic osteomyelitis , although adverse effects are a significant concern when long @-@ term use is necessary . 
