 For a while , Manco Inca and the conquistadors maintained cordial relations , together they defeated Atahualpa 's generals and reestablished Inca rule over most of the empire . However , Manco came to realize that real authority rested in Spanish hands when his house was looted with impunity by a Spaniard mob in 1535 . Following this episode , the Inca emperor was subject to constant harassment as the Spaniards demanded gold , took away his wives , and even imprisoned him . In response , he fled his capital to start an uprising . In May 1536 , an Inca army besieged Cusco , which was garrisoned by a group of Spaniards and native allies . The conquistadors were hard pressed but they managed to resist and counterattack , storming the main Inca stronghold at <unk> . Meanwhile , Manco 's generals occupied the central highlands of Peru and annihilated several expeditions sent to reinforce Cusco but failed in their attempt to take the recently founded Spanish capital of Lima . As a result of these events , neither side was able to break the deadlock at Cusco for several months , so the Spaniard garrison decided to make a direct attack on Manco 's headquarters at the town of Ollantaytambo , 70 kilometers ( 43 mi ) northwest of the city . 
