 It has been shown that out of all dog breeds , it is the Labrador Retriever that is most likely to obese . In a 2016 published study it was shown that out of 310 Labradors , most were missing all or parts of the POMC gene . This gene plays a part in appetite regulation as well as indication of the amount of one 's stored fat . The study concluded that the absence of that gene had a significant impact on Labrador weight and appetite . The POMC gene mutation is present in only one other breed - the Flat @-@ coated Retriever . 
