 Following Armageddon , Orton entered the 2006 Royal Rumble match as the thirtieth and final wrestler , but he was eliminated by Rey Mysterio . Mysterio won the match and a title shot , and Orton urged him to put the title shot at stake in a match at No Way Out . In the weeks preceding No Way Out , Orton made controversial remarks about Eddie Guerrero , Mysterio 's friend who had died a few months previously , in an attempt to gain villain heat . Many fans felt the comments were highly distasteful so soon after Guerrero 's death in November 2005 . Orton won at No Way Out , earning Mysterio 's title shot for the World Heavyweight Championship at WrestleMania 22 . General Manager Theodore Long re @-@ added Mysterio to the WrestleMania 22 title match , however , making it a Triple Threat match between Orton , Mysterio , and then @-@ champion , Kurt Angle . On April 2 , at WrestleMania 22 , Orton was pinned by Mysterio , making Mysterio the World Heavyweight Champion and ending their on @-@ screen rivalry . 
