 Following the commercial success of this game , Nintendo released several follow @-@ up titles in the Dr. Mario series . Dr. Mario 64 , released in 2001 for the Nintendo 64 , features Wario and several Wario Land 3 characters , and offers numerous game modes , including a story @-@ focused single @-@ player mode . The game also supports simultaneous multiplayer for up to four players at once . Dr. Mario 64 was subsequently released in Japan in the compilation game Nintendo Puzzle Collection on the Nintendo GameCube . Dr. Mario Online Rx , released in 2008 on WiiWare , offers online multiplayer via Nintendo Wi @-@ Fi Connection . Dr. Mario Express , released in 2009 for the Nintendo DSi , does not support multiplayer gameplay . Dr. Luigi , released in 2013 , features Luigi as a playable character and has all the modes in Dr. Mario Online Rx , as well as a new mode with L @-@ shaped capsules . The latest installment , Dr. Mario : Miracle Cure , was released 2015 and introduced power @-@ ups to the series . 
