 In research involved with the Grand Challenges in Global Health initiative , Rosetta has been used to computationally design novel homing endonuclease proteins , which could eradicate Anopheles gambiae or otherwise render the mosquito unable to transmit malaria . Being able to model and alter protein – DNA interactions specifically , like those of homing endonucleases , gives computational protein design methods like Rosetta an important role in gene therapy ( which includes possible cancer treatments ) . 
