 The swollen , inflamed muscle may directly compress structures in the same fascial compartment , causing compartment syndrome . The swelling may also further compromise blood supply into the area . Finally , destroyed muscle cells release potassium ions , phosphate ions , the heme @-@ containing protein myoglobin , the enzyme creatine kinase and uric acid ( a breakdown product of purines from DNA ) into the blood . Activation of the coagulation system may precipitate disseminated intravascular coagulation . High potassium levels may lead to potentially fatal disruptions in heart rhythm . Phosphate binds to calcium from the circulation , leading to low calcium levels in the blood . 
