 Lexie entertained several relationships throughout her time on Grey 's Anatomy . In her early appearances , she maintained a friendship with George O 'Malley , until developing romantic feelings towards him . Rhimes offered the insight : " I love them as friends . They make good friends . We all have that friend we met in school or the gym or somewhere – we just hit it off right away . And right away there was no pretense or airs . Just pure honesty . That ’ s Lexie and George . They ’ re really good friends and I can see the friendship evolving into something even greater . At least , that ’ s what Lexie is hoping . She is my kind of girl . The girl who likes the guy because he is a GOOD guy and that ’ s what George is . He is a good guy and that ’ s something that Lexie could use now . She ’ s going through her own challenges what with Meredith and losing her own mother and trying to keep things afloat . I ’ m rooting for Lexie . She ’ s my kind of girl and I hope that she gets what she deserves : love . And more kisses . There should always be that . " Lexie 's most significant relationship was with Mark Sloan . Following her death , Rhimes said : 
