 Using a standard laboratory method to determine antimicrobial susceptibility , methanol @-@ based extracts of Strobilurus tenacellus fruit bodies were shown in a 2000 study to have low antibacterial activity against the bacterium Bacillus subtilis , and low to moderate activity against the fungi Candida albicans and Aspergillus fumigatus . The fungus produces the natural antibiotic strobilurin A , which was reported as a novel compound from this species in 1977 ; other strobilurins have since been found in other basidiomycete wood @-@ rotting fungi , like Porcelain Mushroom for example . <unk> A is thought to be derived biosynthetically from the amino acid L @-@ phenylalanine . In nature , the fungus secretes the chemical to prevent invasion by other fungi that challenge its nutrient source . It works by blocking electron transfer in the mitochondria , stopping respiration by binding to the <unk> oxidation center of the <unk> complex . This prevents the competing fungus from creating its own energy and inhibiting its growth at the earliest stages of the life cycle , the spore germination stage . The fungus is resistant to its own chemical because its <unk> has three amino acid residues that prevent the strobilurins from binding . Because of their sensitivity to light , and high vapor pressures that causes them to rapidly disappear when applied to the surface of a leaf , chemically unmodified strobilurins are not generally useful as fungicides for agricultural use . The strobilurin @-@ derived compound <unk> , ﬁrst made commercially available in 1996 , was designed to overcome these limitations . It is the world 's biggest @-@ selling fungicide . Other commercial fungicides developed from the strobilurins include Allegro , and Brio ( <unk> @-@ methyl ) <unk> . 
