 Because of their completely unnatural backbones , Morpholinos are not recognized by cellular proteins . Nucleases do not degrade Morpholinos , nor are they degraded in serum or in cells . Morpholinos do not activate toll @-@ like receptors and so they do not activate innate immune responses such as interferon induction or the NF @-@ κB @-@ mediated inflammation response . Morpholinos are not known to modify methylation of DNA . 
