 The most common conditions associated with thrombophilia are deep vein thrombosis ( DVT ) and pulmonary embolism ( PE ) , which are referred to collectively as venous thromboembolism ( VTE ) . DVT usually occurs in the legs , and is characterized by pain , swelling and redness of the limb . It may lead to long @-@ term swelling and heaviness due to damage to valves in the veins . The clot may also break off and migrate ( <unk> ) to arteries in the lungs . Depending on the size and the location of the clot , this may lead to sudden @-@ onset shortness of breath , chest pain , palpitations and may be complicated by collapse , shock and cardiac arrest . 
