 It is not understood how the activated RISC complex locates complementary mRNAs within the cell . Although the cleavage process has been proposed to be linked to translation , translation of the mRNA target is not essential for RNAi @-@ mediated degradation . Indeed , RNAi may be more effective against mRNA targets that are not translated . <unk> proteins are localized to specific regions in the cytoplasm called P @-@ bodies ( also cytoplasmic bodies or GW bodies ) , which are regions with high rates of mRNA decay ; miRNA activity is also clustered in P @-@ bodies . Disruption of P @-@ bodies decreases the efficiency of RNA interference , suggesting that they are a critical site in the RNAi process . 
