 There is no specific treatment for thrombophilia , unless it is caused by an underlying medical illness ( such as nephrotic syndrome ) , where the treatment of the underlying disease is needed . In those with unprovoked and / or recurrent thrombosis , or those with a high @-@ risk form of thrombophilia , the most important decision is whether to use anticoagulation medications , such as warfarin , on a long @-@ term basis to reduce the risk of further episodes . This risk needs to weighed against the risk that the treatment will cause significant bleeding , as the reported risk of major bleeding is over 3 % per year , and 11 % of those with major bleeding may die as a result . 
