 RosettaDesign , a computational approach to protein design based on Rosetta , began in 2000 with a study in redesigning the folding pathway of Protein G. In 2002 RosettaDesign was used to design <unk> , a 93 @-@ amino acid long α / β protein that had an overall fold never before recorded in nature . This new conformation was predicted by Rosetta to within 1 @.@ 2 Å RMSD of the structure determined by X @-@ ray crystallography , representing an unusually accurate structure prediction . Rosetta and RosettaDesign earned widespread recognition by being the first to design and accurately predict the structure of a novel protein of such length , as reflected by the 2002 paper describing the dual approach prompting two positive letters in the journal Science , and being cited by more than 240 other scientific articles . The visible product of that research , <unk> , was featured as the RCSB PDB 's ' Molecule of the Month ' in October 2006 ; a superposition of the respective cores ( residues 60 – 79 ) of its predicted and X @-@ ray crystal structures are featured in the Rosetta @ home logo . 
