 In people without a detectable thrombophilia , the cumulative risk of developing thrombosis by the age of 60 is about 12 % . About 60 % of people who are deficient in antithrombin will have experienced thrombosis at least once by age 60 , as will about 50 % of people with protein C deficiency and about a third of those with protein S deficiency . People with activated protein C resistance ( usually resulting from factor V Leiden ) , in contrast , have a slightly raised absolute risk of thrombosis , with 15 % having had at least one thrombotic event by the age of sixty . In general , men are more likely than women to experience repeated episodes of venous thrombosis . 
