 Amtrak 's Lake Shore Limited arrives at Union Station twice daily , westbound from New York Penn Station and Boston South Station , and eastbound from Chicago Union Station , with scheduled arrivals in the middle of the night and in the early morning , respectively , as of January 11 , 2016 . Union Station is on the Lake Shore Subdivision , the CSX Transportation main line from Erie to Buffalo , New York , at railroad milepost 86 @.@ 9 . It is 436 miles ( 702 km ) east of Chicago , 523 miles ( 842 km ) west of New York City , and 723 miles ( 1 @,@ 164 km ) from Boston . The next station west of Erie is Cleveland Lakefront , and eastbound is Buffalo – Depew . The station was the 13th busiest in Pennsylvania during fiscal year 2015 with an annual ridership of 16 @,@ 633 passengers , a decrease of 9 @.@ 2 percent from the previous year . 
