 Intelligent Systems for Molecular Biology ( ISMB ) is an annual academic conference on the subjects of bioinformatics and computational biology organised by the International Society for Computational Biology ( ISCB ) . The principal focus of the conference is on the development and application of advanced computational methods for biological problems . The conference has been held every year since 1993 and has grown to become one of the largest and most prestigious meetings in these fields , hosting over 2 @,@ 000 delegates in 2004 . From the first meeting , ISMB has been held in locations worldwide ; since 2007 , meetings have been located in Europe and North America in alternating years . Since 2004 , European meetings have been held jointly with the European Conference on Computational Biology ( ECCB ) . 
