 Linezolid is a weak monoamine oxidase inhibitor ( MAOI ) , and should not be used concomitantly with other MAOIs , large amounts of tyramine @-@ rich foods ( such as pork , aged cheeses , alcoholic beverages , or smoked and pickled foods ) , or serotonergic drugs . There have been postmarketing reports of serotonin syndrome when linezolid was given with or soon after the discontinuation of serotonergic drugs , particularly selective serotonin reuptake inhibitors such as paroxetine and sertraline . It may also enhance the blood pressure @-@ increasing effects of sympathomimetic drugs such as pseudoephedrine or phenylpropanolamine . It should also not be given in combination with pethidine ( meperidine ) under any circumstance due to the risk of serotonin syndrome . 
