 It was reported originally that the film would feature both Mary Jane Watson and Gwen Stacy as love interests , but the website The Wrap later reported that only Gwen Stacy would appear . In August 2010 , the list of candidates included Lily Collins , Ophelia Lovibond , and Imogen Poots , with Teresa Palmer , Emma Roberts , and Mary Elizabeth Winstead cited by The Hollywood Reporter as " potentially in the mix " . In September 2010 , Variety reported that the shortlist had expanded to include Stone and Mia Wasikowska . The shortlist was reported to then include Dianna Agron , Georgina Haig and Dominique McElligott . On October 5 , 2010 , the choice of Stone was confirmed . Webb noted that the chemistry between Stone and Garfield made her the clear choice . That chemistry inspired their off @-@ screen romance . 
