 RNA interference has been used for applications in biotechnology and is nearing commercialization in others . RNAi has developed many novel crops such as nicotinefree tobacco , decaffeinated coffee , nutrient fortified and hypoallergenic crops . The genetically engineered Arctic apples are near close to receive US approval . The apples were produced by RNAi suppression of PPO ( polyphenol oxidase ) gene making apple varieties that will not undergo browning after being sliced . PPO @-@ silenced apples are unable to convert chlorogenic acid into quinone product . 
