 The character of Dr. Mario appears as an unlockable playable character in the 2001 fighting game Super Smash Bros. Melee , where he attacks by throwing capsules known as " Megavitamins " . There are two ways to unlock Dr. Mario as a playable character , either by completing Classic , Adventure or All @-@ Star mode with Mario ( using no continues ) or by completing 100 melee battles . The game 's sequel , Super Smash Bros. Brawl , does not feature Dr. Mario as a playable character , but it includes the Melee remix of Dr. Mario 's " Fever " background music theme and a version of the " Chill " theme music arranged by Masaaki Iwasaki , who had previously composed for Magical Drop as part of the Data East Sound Team . Dr. Mario characters also appear in the game as collectible stickers . Dr. Mario would later return as an unlockable playable character in Super Smash Bros. for Nintendo 3DS and Wii U. 
