 Rapid sequence induction and intubation ( RSI ) is a particular method of induction of general anesthesia , commonly employed in emergency operations and other situations where patients are assumed to have a " full stomach " . The objective of RSI is to minimize the possibility of regurgitation and pulmonary aspiration of gastric contents during the induction of general anesthesia and subsequent tracheal intubation . RSI traditionally involves preoxygenating the lungs with a tightly fitting oxygen mask , followed by the sequential administration of an intravenous sleep @-@ inducing agent and a rapidly acting neuromuscular @-@ blocking drug , such as rocuronium , succinylcholine , or cisatracurium besilate , before intubation of the trachea . 
