 PA 12 begins at an interchange with US 222 and US 422 in Wyomissing . Southwest of this interchange , the Warren Street Bypass continues as part of southbound US 222 / westbound US 422 . US 222 northbound continues northwest and US 422 eastbound continues southeast on the West Shore Bypass . PA 12 does not have access to or from the northbound direction of US 222 at this interchange . From US 222 / US 422 , the route heads northeast on the four @-@ lane divided Warren Street Bypass . PA 12 crosses Tulpehocken Creek into Reading and heads through commercial areas . Along this stretch , the route has no cross traffic , with access to some local streets as well as businesses while access to other local cross streets is blocked by barricades . The road comes to an interchange with PA 183 , with access provided from right @-@ in / right @-@ out ramps to Butler Street and Lehigh Street in the northbound direction and to Carbon Street and Lackawanna Street in the southbound direction . The PA 183 interchange provides access to Reading Regional Airport , an airport with charter flights that is also home to the Mid @-@ Atlantic Air Museum . Following this interchange , the route becomes a freeway and heads near residential neighborhoods and turns north , running to the west of Norfolk Southern 's Reading Line . PA 12 crosses the Schuylkill River and comes to a partial cloverleaf interchange with River Road . 
