 In 2008 , the crystal structure of linezolid bound to the 50S subunit of a ribosome from the archaean Haloarcula marismortui was elucidated by a team of scientists from Yale University and deposited in the Protein Data Bank . Another team in 2008 determined the structure of linezolid bound to a 50S subunit of Deinococcus radiodurans . The authors proposed a refined model for the mechanism of action of oxazolidinones , finding that linezolid occupies the A site of the 50S ribosomal subunit , inducing a conformational change that prevents tRNA from entering the site and ultimately forcing tRNA to separate from the ribosome . 
