 The exact incidence of rhabdomyolysis is difficult to establish , because different definitions have been used . In 1995 , hospitals in the U.S. reported 26 @,@ 000 cases of rhabdomyolysis . Up to 85 % of people with major traumatic injuries will experience some degree of rhabdomyolysis . Of those with rhabdomyolysis , 10 – 50 % develop acute kidney injury . The risk is higher in people with a history of illicit drug use , alcohol misuse or trauma when compared to muscle diseases , and it is particularly high if multiple contributing factors occur together . Rhabdomyolysis accounts for 7 – 10 % of all cases of acute kidney injury in the U.S. 
