 The Binding of Isaac 's plot is loosely inspired by the biblical story of the same name . Isaac , a child , and his mother live in a small house on a hill , both happily keeping to themselves , with Isaac drawing pictures and playing with his toys , and his mother watching Christian broadcasts on television . Isaac 's mother then hears " a voice from above " , stating her son is corrupted with sin , and needs to be saved . It asks her to remove all that was evil from Isaac , in an attempt to save him . His mother obliges , taking away his toys , drawings , and even his clothes . 
