 Harrison County is located in the far southern part of Indiana , about halfway between the state 's east and west borders . The Ohio River defines the county 's southern border ; across the river lies the state of Kentucky and the city of Louisville . The Blue River runs along the county 's western border . Six counties are adjacent to Harrison County . Three are in Indiana : Washington County to the north , Floyd County to the east , and Crawford County to the west . The other three are in Kentucky : Jefferson County and Hardin County are to the southeast and Meade County is to the south . 
