 US 45 crosses from Wisconsin to Michigan near Land O ' Lakes , Wisconsin , east of the Sylvania Wilderness area of the Ottawa National Forest . The highway angles northeast from the state line before curving around to the north toward Watersmeet , where it intersects US 2 . Watersmeet is home to the northern section of the Lac Vieux Desert Indian Reservation . Continuing north across the Gogebic – Ontonagon county line , US 45 crosses the boundary between the Central and Eastern time zones . 
