 The overall economic impact of the bioscience industry in Ohio , including healthcare , amounted to $ 148 @.@ 2 billion in 2007 , representing 15 @.@ 7 % of Ohio 's economic output . Half of the biotech industry is located in northeast Ohio , with 574 firms , while central and southern Ohio are home to around 200 each . 635 companies are FDA @-@ certified to manufacture medical devices . Biotech research and development employs directly 12 @,@ 415 residents , while agricultural bioscience contributed the largest economic impact , at $ 10 @.@ 7 billion . Medical device manufacturers employ 9 @,@ 757 residents . 
