 U.S. Route 22 ( US 22 ) is a U.S. highway stretching from Cincinnati , Ohio in the west to Newark , New Jersey in the east . In New Jersey , the route runs for 60 @.@ 53 mi ( 97 @.@ 41 km ) from the Easton @-@ Phillipsburg Toll Bridge over the Delaware River in Phillipsburg , Warren County to Interstate 78 ( I @-@ 78 ) , US 1 / 9 , and Route 21 at the Newark Airport Interchange in Newark , Essex County . The road first heads through the Phillipsburg @-@ Alpha area as a surface divided highway before running concurrent with I @-@ 78 through mountainous and agricultural sections of western New Jersey between Alpha and east of Clinton in Hunterdon County . For the remainder of the route , US 22 runs to the south of I @-@ 78 through mostly suburban areas as a four- to six @-@ lane surface divided highway , passing through Hunterdon , Somerset , Union , and Essex counties . Along this portion , it intersects US 202 and US 206 in Somerville , I @-@ 287 in Bridgewater Township , and the Garden State Parkway in Union . 
