 Angle @-@ resolved low @-@ coherence interferometry ( a / LCI ) uses scattered light to measure the sizes of subcellular objects , including cell nuclei . This allows interferometry depth measurements to be combined with density measurements . Various correlations have been found between the state of tissue health and the measurements of subcellular objects . For example , it has been found that as tissue changes from normal to cancerous , the average cell nuclei size increases . 
