 Approximately 1 in 10 documented cases of hyperparathyroidism are a result of hereditary factors . Disorders such as familial hyperparathyroidism , multiple endocrine neoplasia type 1 ( MEN Type 1 ) and hyperparathyroidism @-@ jaw tumor syndrome can , if left unchecked , result in OFC . MEN Type 1 is an autosomal dominant disorder and the most common hereditary form of hyperparathyroidism , affecting about 95 % of genetic cases of OFC , and also tends to affect younger patients than other forms . Major mutations which can lead to hyperparathyroidism generally involve the parathyroid hormone receptor , G proteins , or adenylate cyclase . Certain genetic mutations have been linked to a higher rate of parathyroid carcinoma occurrence , specifically mutations to the gene HRPT2 , which codes for the protein parafibromin . 
