 Five volumes of the Grey 's Anatomy Original Soundtrack have been released as of 2011 . For the first two seasons , the show 's main title theme was an excerpt from " Cosy in the Rocket " , by British duo Psapp ; it is featured on the first soundtrack album released via ABC 's corporate cousin , Hollywood Records , on September 27 , 2005 . The second soundtrack , featuring songs from the series ' second season , was released on September 12 , 2006 , followed by a third soundtrack with music from the third season . Following the seventh season musical episode " Song Beneath the Song " , " Grey 's Anatomy : The Music Event " soundtrack was released , with volume four of the soundtrack released subsequently . 
