 Later syntheses have included an " atom @-@ economical " method starting from D @-@ mannitol , developed by Indian pharmaceutical company Dr. Reddy 's and reported in 1999 , and a route starting from ( S ) -glyceraldehyde acetonide ( prepared from vitamin C ) , developed by a team of researchers from Hunan Normal University in Changsha , Hunan , China . On June 25 , 2008 , during the 12th Annual Green Chemistry and Engineering Conference in New York , Pfizer reported the development of their " second @-@ generation " synthesis of linezolid : a convergent , green synthesis starting from ( S ) -epichlorohydrin , with higher yield and a 56 % reduction in total waste . 
