 Spears first performed " Me Against the Music " at the 2003 NFL Kickoff Live on September 4 , 2003 at the National Mall . The performance segued into a medley of " ... Baby One More Time " and " I 'm a Slave 4 U " , which included pyrotechnics . On September 14 , 2003 , Spears played a surprise concert at Rain Nightclub in the Palms Casino Resort , and performed " Me Against the Music " , " Breathe on Me " and a medley of " ... Baby One More Time " and " I 'm a Slave 4 U " . On October 18 , 2003 , Spears performed " Me Against the Music " and " Everytime " during the twenty @-@ ninth season of Saturday Night Live . Spears opened the 2003 American Music Awards telecast with a performance of " Me Against the Music " . On November 17 , 2003 , a concert special titled Britney Spears : In the Zone aired in ABC . The following day , she performed " Me Against the Music " and " ( I Got That ) Boom Boom " on the American music show TRL at Times Square . " Me Against the Music " was also performed on American late @-@ night show The Tonight Show with Jay Leno and American morning show Live with Regis and Kelly on November 17 and 24 , 2003 . She performed " Toxic " , " Breathe on Me " and " Me Against the Music " as the headliner of the Jingle Ball on December 8 , 2003 , at the Staples Center . On January 24 , 2004 , Spears opened the 2004 NRJ Music Awards with a performance of " Toxic " . On August 5 , 2004 , Spears performed " Everytime " at the British music chart show Top of the Pops . 
