 The Annunciation is typically set in domestic interiors in Early Netherlandish art , a style Robert Campin established , and Jan van Eyck and Rogier van der Weyden followed . Neither Campin nor van Eyck went so far as to set the scene in a bedchamber , although the motif is found in van der Weyden 's c . 1435 Louvre Annunciation and c . 1455 Saint Columba altarpiece in which the Virgin kneels by the nuptial bed , rendered in red made from costly pigments . Memling 's depiction is nearly identical to van der Weyden 's Columba Altarpiece . 
