 Donna Jackson is a fictional character from the BBC medical drama Holby City , played by actress Jaye Jacobs . She appeared in the programme from its sixth series in 2004 , to its thirteenth in 2011 . Donna entered the series as a staff nurse , characterised as a wild @-@ child with a chaotic personal life . During her tenure , she grew to take her work more seriously , becoming a ward sister and accepting more personal responsibilities by adopting her half @-@ niece Mia ( Jada Wallace @-@ Mitchell ) . A tart with a heart character , Donna had many romantic liaisons with her colleagues , including a one @-@ night stand with midwife Mickie Hendrie ( Kelly Adams ) . She ultimately fell in love with agency nurse Keiran Callaghan ( Barry Sloane ) , and departed to be with him after he was injured in Afghanistan as part of the Territorial Army . 
