text: On one grand boulevard , the Paseo del Prado , are three of Europe 's finest the world-class Prado museum , the Thyssen-Bornemisza collection , and the Centro de Arte Reina Sof ? ­ a ( Queen Sof ? ­ a Art Ceter ) , whose claim to fame is the 20th century 's most famous painting , Pablo Picasso 's Guernica .
  
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  One of the most famous 20th century 's painting is held in the Centro de Arte Reina Sofia .