i got a positive mantoux test next year recieved a negative reading, the year after that I got a negative reading next year a positive reading. 2 weeks later I got CFS and have had it for 4 years. My question is the repeated tst after having a positve reading, could have caused an immune response with symtoms of CFS?
No one knows for sure what causes CFS, so no definite connection can be made between the TB tests. CFS has been associated with acute events or illnesses, i.e. you get sick with something and shortly afterward develop CFS. It's not uncommon to get TB tests annually, so I doubt that is a direct cause. You did have an evaluation (e.g., chest x-ray) for the positive one, I hope. Tests don't usually change back to negative unless the immune response is suppressed. CFS is a diagnosis of exclusion, so you want to be sure you still don't have TB in your system that is causing your symptoms. Hope this answers your query.