I am a 60 year old man taking a l lot of medicine for very deep depression and pain from multiple myeloma . Something is not right and I am getting deeper into depression. citalopram 40 mg - have taken for several years olanzapine 5 mg - as needed trazodone 50 mg take each day zolpidem , 10 mg have taken several years Hydrocodone/ APAP 5-500M - as needed
Hi, Since your depression is not responding to citalopram 40 mg, you need other interventions. There are three options. The dose of citalopram can be hiked to see if it gives a better response. But this must be done with caution as you are already on a fairly high dose. Secondly, other medicines can be added to citalopram to augment its action, like thyroid hormone, lithium, a second antidepressant etc. The third thing that can be done is to switch to another antidepressant that may give better results. Venlafaxine would be a good choice in my opinion. Please discuss with your doctor the option that would suit you best and do accordingly. Hope you get better soon. Best wishes.