I have a nephew that has Sanflippo Sydrome MPS III.....we are currently dealing with joint issues and the inability to be more mobile....Are there any antiimflammatory meds that could possibly help him? We know he is terminal....just trying to keep him as mobile and out of pain as possible.
Hello, ERT-Enzyme replacement therapy (elosulfase alpha) has been shown to improve ambulatory mobility and decrease pain in other related Mucopolysaccharidosis (MPS type IV) but ERT has not been shown to be effective in MPS III. Both non-opioid and opioid Chat Doctor.  Paracetamol for mild pain, Ibuprofen, Naproxene, Piroxicam for moderate pain has been used. NSAIDs need after food administration to reduce GI side effects. Antacids are often prescribed with NSAIDs. Paracetamol is generally free of adverse effects when administered in appropriate therapeutic doses and is most commonly used. Hope I have answered your query. Let me know if I can assist you further. Take care