I have elevated liver enzymes of alt 250 and ast 171. I am on depakote for about 20 yrs for bipolar. 1000 mg.The dr seems to think that s the problem and ordered an ultrasound. I m nervous. I have lost 15lbs by eating a very healthy diet of vegetables and fruits and whole grains. Anything you can tell me would be helpful please. I have no pain.
Hi, I had gone through your question and understand your concerns. Sodium valproate is the sodium salt of Valerie acid and is an anticonvulsant used in the treatment of epilepsy, panic attack, anxiety disorder, migraine and bipolar disorder, as well as other psychiatric conditions requiring the administration of a mood stabilizer. Sodium valproate is a weak blocker of sodium ion channels; it is also a weak inhibitor of enzymes that deactivate GAZA such as GAZA transaminase. It may also stimulate the synthesis of GAZA. It does have many adverse effects. Yes it can rarely cause liver damage, hence cause a rise in ALT and AST. Do not be nervous. Your doctor has rightly ordered for an abdominal ultrasound to look for the liver affection. Keep in touch with your doctor. He/she can examine you and correlate clinically and guide on the exact management. Hope this answers your question. If you have additional questions or follow-up questions then please do not hesitate in writing to us. I will be happy to answer your questions. Wishing you good health.