Dear Dr. My Son has Glanzmanns Thromboaesthnia, a few days back he has caught cold with a bit of runny nose , is it advisable to give him Anti Histamine like cetrzine Hydrochloride[Relent, Alreid], as it might cause nose bleed also, Please suggest any other anti allergic which do not cause nose bleed. Regards Ankur
Hello Anger, You have asked quite a difficult yet pertinent question. The Glib/Ilia def is functional, and can affect platelet function, and as far as studies are concerned with platelet and antihistamines it is usually a decrease in number (though rare). Fexofenadine is a long acting 2nd generation antihistamine and the SPC of fexofenadine does not mention any such platelet problem. You are advised to discuss with your Hematologist if still in doubt. Thanks.