hello doctor,my mother has stage 3/4 heartfailure, she is 54 years old. in the past few months her crp levels are very high 60plus but the docs say they dont want to treat it until they know the infection site they have done many ct and mri scans aswell as blood cultures but they havent found teh site. just recently they done a toe aswell but still cant find the infection site. by the way the blood cultures come back negative.now my mothers spleen has enlarged. what is going on and why dont the doctors just administer antibiotic even if they dont know the infection site  ps my mother had a crt d installed 6 months ago but in the toe the docs dont think that the pacemakers leads are infectedhelp plz
In case if the pacemaker leads were infected her TLC /DLC counts would have increased her blood culture and sensitivity test must have been positive for bacteria any infection in body is frequently associated with rise in body temp(Pyrex) as you is a patient of CHF on ICD prophylactic antibiotic therapy can be given for 5 day stab septum 500 twice daily tab lined 600 twice daily CRP is an indicator of infection but it's a very old test and a non-specific marker of infections her spleen has increased in size now I would suggest you to go for a repeat serum calcitonin (a very specific test for indicating infection)blood rm blood c n sesrtlcdlccbcurine r n ma combined analysis of these tests can be helpful in reaching a conclusion