Hello, my brother aged 58 suffering from parkinson disease for more than 20 years.He takes syndopa plus and syndopa cr 1/2 tabs morning and evening.And in the night amantrel caps.The side effect of syndopa is his grip of hands is improving to dine and bath. But he is walking on toes and stooping and falling frequently. With amantrel there is no problem till morning 11am. Night also he does not sleep.Recently i asked him to take amantrel in the day time. his walking posture improved. But he became very weak. Is it because of sudden withdrawl of syndopa?Is there is relacement drug for syndopa without walking side effect?Can he take amantrel twice daily?How to improve his sleeping ?
Hello thanks for asking from ChatDoctorHe is 58 years old and is suffering from Parkinson's disease. He is on Syn dopa plus, Syn dopa CR and Amantadine. Out of these medicines Amantadine is known to cause decreased sleep and may result in activation. You have shifted Amantadine to morning hours, but he has developed weakness. Now coming to your questions-- Apart from Syn dopa medicines Opinion, Pramipaxol can be used in Parkinson. Pramipaxol will help in improving sleep also.-Taking amantadine in evening hours will worsen insomnia. So as per my opinion the dose should be single dose in morning hours.-If don't improve with these medicines then you can consult his doctor to add some sleep medicine like Benzodiazepines for short terms. These medicines will help to improve sleep. Thanks, hope this helps you.