I developed a painful rash on the left side of my scrotum. it appeared after using Efudex on my arms and back, after which I used a steroidal healing cream. The rash appeared on my scrotum AND around my neck and shoulders where no Efudex was applied?????? Jerry
Hi, Thanks for writing in. Efudex is a strong medication and to be used only with doctors prescription.  Fluorouracil belongs to a class of medications known as anti-metabolites. It works by blocking the growth of abnormal cells that cause the skin condition. Fluorouracil belongs to a class of medications known as anti-metabolites. It works by blocking the growth of abnormal cells that cause the skin condition. The treated area may become unsightly during treatment and in some cases for several weeks after treatment. Skin irritation, burning, redness, Chat Doctor. It is important you go to ER immediately and get required treatment to reduce the rashes in your neck, shoulders and scrotum.