I had a total knee replacement six weeks ago. I have been taking percocet for pain and prior to physical therapy. But in the past three weeks, I have become increasingly depressed and agitated. I have been taking amitryptilene and bupropion for years and it has worked well, but I wonder about the interaction of these with the Percocet. It is alarming to be down in the black hole again. I decided today to stop the Percocet and just tough it through. Do you have any observation or advice about this? I am soooo down.
HiT hanks for using Chat Doctor Percent contains oxycodone, and it is a painkiller. It has no major interaction with amitriptyline or bupropion. You can carry on both of these Chat Doctor.  In your case, anger or irritability could be due to physical issues. In that case, you can either try some another antidepressant or try for some relaxation exercise. With time all these symptoms would improve. In case, you need further help, you can ask. Thanks