Test for statistically significant difference between two arrays
Go to MS Excel.  If you don't have it your work does, there are alternatives 
Enter the array of numbers in Excel worksheet.  Run the formula in the entry field, =TTEST (array1,array2,tail).  One tail is one, Two tail is two...easy peasy.  It's a simple Student's T and I believe you may still need a t-table to interpret the statistic (internet).  Yet it's quick for on the fly comparison of samples.
I have two 2-D arrays with the same shape (105,234) named A & B essentially comprised of mean values from other arrays.  I am familiar with Python's scipy package, but I can't seem to find a way to test whether or not the two arrays are statistically significantly different at each individual array index.  I'm thinking this is just a large 2D paired T-test, but am having difficulty. Any ideas or other packages to use?