Although there is no cure for the common cold, treatment can relieve the most bothersome symptoms. 1 Nasal congestion, for instance, can be relieved with topical decongestants, such as xylometazoline hydrochloride. 14 Xylometazoline hydrochloride is a nasal decongestant that constricts nasal blood vessels leading to reduction in mucosal swelling and increasing nasal airflow, allowing patients to breathe more easily during episodes of nasal congestion.6,14