The five remaining QoL factors were assessed individually; these were ‘think clearly’ (Q12), ‘work outside home’(Q17), ‘work inside the home’ (Q18), and ‘live your personal life’ (Q20) from the WURSS-21 questionnaire, and ‘being self-conscious about how you sound’ (Q3) from the additional QoL questionnaire. The mean (±SE) scores for each individual QoL factor at baseline are shown in Table 11. All ranged between 3.5 and 4.2, which could be considered mild (score = 3) to moderate (score = 5) in severity level. After treatment with xylometazoline hydrochloride 0.1%, significant improvements from day 1 were seen in ‘live your personal life’ and ‘being self-conscious about how you sound’ factors. ‘Work inside the home’ and ‘work outside the home’ showed a significant improvement from day 2 (Table 11). ‘Think clearly’ improved from day 3, a day later to the ‘head congestion’ symptom, which improved from day 2 (Supplemental Table 2).