Post hoc analyses Post hoc analyses were evaluated using the mITT population. The changes from baseline in mean WURSS-21 individual QoL scores were analyzed each day using a Student’s paired t-test, and p-values were assessed to a significance level of α = 0.05. The median times to resolution of WURSS-21 individual QoL domains were analyzed using Kaplan–Meier curves. Correlations and significance between the WURSS-21 ‘plugged nose’ symptom, the WURSS-21 individual QoL domains (WURSS-21 questions 12–20), and the eight additional QoL factors were calculated using the Pearson correlation coefficient. The over-time effect of xylometazoline hydrochloride 0.1% was evaluated in five QoL categories (Table 3). The changes from baseline for the mean of each QoL category score were analyzed each day using a Student’s paired t-test, and p-values were assessed to a significance level of α = 0.05.