The vitality category mean score (±SE) at baseline was 19.1 (±0.50) and considered as moderate severity level (score = 20). The individual factors had mean scores within the range of 3.8–5.2, indicating a moderate severity level (score = 5) for each score at baseline (Table 7). The overall vitality category and its corresponding QoL factors showed a statistically significant improvement from day 1 (p < 0.0001). ‘Feeling tired’, which is one of the WURSS-21 symptom factor, significantly improved by day 2 (p = 0.0364). At the time of the observed significance, the scores had dropped from moderate severity to a mild severity level. By the last dose used for all participants, ‘motivation’ improved by 83.2%, ‘energy’ by 83.1%, ‘alertness’ by 85.9%, and ‘feeling tired’ improved by 53.6%. By the last dose of treatment, the vitality category score improved by 76.1% (Table 7).