Ethics approval and consent to participate: This study was conducted in compliance with the protocol and in accordance with Good Clinical Practices Medicines and Healthcare products Regulatory Agency regulations, and all applicable local and state regulations. Signature of the eIC was required and obtained from all participants before any study-related activities. The eIC was reviewed by West Midlands, Edgbaston, Research Ethics Committee, Manchester, UK. IRAS project ID 1006069, REC:22/WM/0177. Approved by West Midlands – Edgbaston Research Ethics Committee 25 October 2022.