Sleep has also been shown to impact QoL factors related to vitality, such as ‘energy’, ‘motivation’, and ‘alertness’ (being slow in response).31,37 In this study, all QoL factors for vitality had improved from day 1, corroborating findings from the sleep quality category. A previous study showed that nasal decongestion with intranasal corticosteroids in allergic rhinitis was associated with improved sleep and reduced daytime fatigue. 28 In this study, the symptom of ‘plugged nose’ from the WURSS-21 questionnaire significantly improved from day 1, and the WURSS-21 individual symptom factor of ‘feeling tired’ showed a significant improvement from day 2, suggesting that xylometazoline hydrochloride 0.1% decongestion effect may also benefit patients experiencing the common cold.