The individual WURSS-21 symptom domain score ranges from 0 to 7 (Table 1), in which higher scores indicate higher severity. Of the 10 individual symptoms assessed using the WURSS-21 questionnaire, ‘plugged nose’, ‘runny nose’, ‘head congestion’, and ‘feeling tired’ scored a mean baseline score of at least 4, representing a mild (score = 3) to moderate (score = 5) severity level. These individual symptoms generally showed the greatest percentage improvement by the last day of dose administered (Supplemental Table 2). A statistically significant improvement in ‘plugged nose’ (p = 0.0023) was observed from day 1 post-treatment [Figure 3(d) and Supplemental Table 2]. The mean ± SE score for ‘plugged nose’ at baseline was 5.5 (±0.09), which represents a moderate to severe level for this symptom. By the last dose of xylometazoline hydrochloride 0.1% was used, the ‘plugged nose’ symptom improved by 68.1% and dropped to a mean (±SE) score of 1.8 (±0.16), which represents a very mild-to-absent severity level. All 10 symptom scores improved by at least 50% from baseline at the last dose (Supplemental Table 2).