text: from scaden.simulation import BulkSimulator
  
  """
  Simulation of artificial bulk RNA-seq samples from scRNA-seq data
  and subsequenbt formatting in .h5ad file for training with Scaden
  """
  
  
  def simulation(simulate_dir, data_dir, sample_size, num_samples, pattern,
                 unknown_celltypes, out_prefix, fmt):
  
      unknown_celltypes = list(unknown_celltypes)
      bulk_simulator = BulkSimulator(sample_size=sample_size,
                                     num_samples=num_samples,
                                     data_path=data_dir,
                                     out_dir=simulate_dir,
                                     pattern=pattern,
                                     unknown_celltypes=unknown_celltypes,
                                     fmt=fmt)
  
      # Perform dataset simulation
      bulk_simulator.simulate()
  
      # Merge the resulting datasets
      bulk_simulator.merge_datasets(data_dir=simulate_dir,
                                    files=bulk_simulator.dataset_files,
                                    out_name=out_prefix + ".h5ad")
  