text: # -*- coding: utf-8 -*-
  
  """An example describing a single evidence about BRAF.
  
  .. code-block:: none
  
      SET Citation = {"PubMed", "11283246"}
      SET Evidence = "Expression of both dominant negative forms, RasN17 and Rap1N17, in UT7-Mpl cells decreased
      thrombopoietin-mediated Elk1-dependent transcription. This suggests that both Ras and Rap1 contribute to
      thrombopoietin-induced ELK1 transcription."
  
      SET Species = 9606
  
      p(HGNC:THPO) increases kin(p(HGNC:BRAF))
      p(HGNC:THPO) increases kin(p(HGNC:RAF1))
      kin(p(HGNC:BRAF)) increases tscript(p(HGNC:ELK1))
  
      UNSET ALL
  """
  
  from ..dsl import Entity, Protein, activity
  from ..resources import HGNC_URL, SPECIES_PATTERN
  from ..struct.graph import BELGraph
  
  __all__ = [
      'braf_graph',
  ]
  
  braf_graph = BELGraph(
      name='BRAF Subgraph',
      version='1.0.0',
      description="Some relations surrounding BRAF",
      authors='Charles Tapley Hoyt',
      contact='cthoyt@gmail.com',
  )
  
  braf_graph.namespace_url.update({
      'HGNC': HGNC_URL,
  })
  
  braf_graph.annotation_pattern.update({
      'Species': SPECIES_PATTERN,
  })
  
  thpo = Protein(
      namespace='HGNC',
      name='THPO',
      identifier='11795',
      xrefs=[
          Entity(namespace='uniprot', identifier='P40225'),
      ],
  )
  braf = Protein(namespace='HGNC', name='BRAF', identifier='1097')
  raf1 = Protein(namespace='HGNC', name='RAF1', identifier='9829')
  elk1 = Protein(namespace='HGNC', name='ELK1', identifier='3321')
  
  evidence = "Expression of both dominant negative forms, RasN17 and Rap1N17, in UT7-Mpl cells decreased " \
             "thrombopoietin-mediated Elk1-dependent transcription. This suggests that both Ras and Rap1 contribute to " \
             "thrombopoietin-induced ELK1 transcription."
  
  braf_graph.add_increases(
      thpo,
      braf,
      evidence=evidence,
      citation='11283246',
      target_modifier=activity(name='kin'),
      annotations={'Species': '9606'},
  )
  
  braf_graph.add_increases(
      thpo,
      raf1,
      evidence=evidence,
      citation='11283246',
      target_modifier=activity(name='kin'),
      annotations={'Species': '9606'},
  )
  
  braf_graph.add_increases(
      braf,
      elk1,
      evidence=evidence,
      citation='11283246',
      source_modifier=activity(name='kin'),
      target_modifier=activity(name='tscript'),
      annotations={'Species': '9606'},
  )
  