IgE to Oligosaccharide Galactose-α-1,3-Galactose and Increased Atheroma Volume
IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics-Brief Report - PubMed

    

    
  
  



  

  

  

  



  



  
    
      
      
        

        


  
    
    
    
    
      
  IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics-Brief Report


    
  


        

        
    
      
        Jeffrey M Wilson et al.
      
    
  
  
    
      
        Arterioscler Thromb Vasc Biol.
      
      
        
          2018 Jul.
        
      
    
  


        
        
        
      
    
  


  



  

  



  
    
      
        Abstract
        
      
      
        
          
            
              
                


  
    
      
        
          Objective:
        
      
      Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal)-the target allergen of delayed anaphylaxis to red meat-is associated with coronary artery disease.
    
  

  


              
                


  
    
      
        
          Approach and results:
        
      
      Total IgE and specific IgE to α-Gal were assayed on sera from 118 subjects who presented for cardiac catheterization and underwent intravascular ultrasound. IgE to α-Gal was detected in 26%, and atheroma burden was higher in sensitized subjects (P=0.02). Because α-Gal sensitization relates to an environmental exposure that could be a risk factor for early-onset coronary artery disease (ie, tick bites), we age stratified the cohort. In subjects ≤65 years of age, the strength of the association with atheroma burden was stronger (P<0.001), and plaques in the sensitized group had less stable features based on intravascular ultrasound. To address the specificity of the association with IgE to α-Gal, IgE to inhalants and peanut were assayed and were not associated with coronary artery disease. Total IgE and α-Gal-specific IgE were strongly associated with each other, but the strength of the relationship with atheroma burden was stronger for α-Gal-specific IgE. This association was significant when adjusted for sex, diabetes mellitus, hypertension, statin use, and total IgE (regression coefficient, 12.2; SE, 5.2; P=0.02).
    
  

  


              
                


  
    
      
        
          Conclusions:
        
      
      Increased atheroma burden and plaques with more unstable features were associated with IgE to α-Gal-an effect most pronounced in subjects ≤65 years of age. IgE sensitization to α-Gal may represent a novel, and potentially modifiable, risk factor for coronary atherosclerosis.
    
  

  


              
            
          
        
      

      
    

    

    
      


  

  
    
      
        
          Keywords:
        
      
      atherosclerosis; galactosyl-(1-3)galactose; immunoglobulin E; red meat; risk factors.
    
  


    

  


  
  


  
    © 2018 American Heart Association, Inc.
  


  
  PubMed Disclaimer

  

  
  
  
    
      
        
          Figures
        

        
          
            
              
                
              

              
              

              
                

                

                
                  
                  



  
    
      Figure.
    
  

  
    A, Representative examples of intravascular ultrasound (IVUS) with fibrous (dark green), fibrofatty (light green), necrotic (red), and calcified plaques (white) evident. B, Results of IVUS in total cohort and when stratified by age. C, Results of IVUS virtual histology in subjects ≤65 y of age. Data in B and C show mean with 95% confidence interval (CI) where each data point represents 1 subject and comparison is with the Mann–Whitney U test. Percentage differences in the mean value between galactose-α-1,3-galactose (α-Gal)–positive and α-Gal–negative subjects within an age group are represented in B by Δ. sIgE indicates specific IgE.
  



                
              

            
          
        

        

        




      
    
  


  

  
  
    
      
        Similar articles
      
      
        
          
  
    
      
  
    
  
  
    
      
        Tick bites, IgE to galactose-alpha-1,3-galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha-gal syndrome.
      
    Wilson JM, Erickson L, Levin M, Ailsworth SM, Commins SP, Platts-Mills TAE.
        
      
    
    Wilson JM, et al.
    Allergy. 2024 Jun;79(6):1440-1454. doi: 10.1111/all.16003. Epub 2024 Jan 9.
    Allergy. 2024.
  
  
  PMID: 38193233
  
  
    
  
  Review.
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        Immunoglobulin E Sensitization to Mammalian Oligosaccharide Galactose-α-1,3 (α-Gal) Is Associated With Noncalcified Plaque, Obstructive Coronary Artery Disease, and ST-Segment-Elevated Myocardial Infarction.
      
    Vernon ST, Kott KA, Hansen T, Finemore M, Baumgart KW, Bhindi R, Yang J, Hansen PS, Nicholls SJ, Celermajer DS, Ward MR, van Nunen SA, Grieve SM, Figtree GA.
        
      
    
    Vernon ST, et al.
    Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):352-361. doi: 10.1161/ATVBAHA.121.316878. Epub 2022 Jan 20.
    Arterioscler Thromb Vasc Biol. 2022.
  
  
  PMID: 35045730
  
  
    
  
  
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        Mammalian Meat Allergy and IgE to Alpha-Gal in Central Virginia: Findings From a COVID-19 Vaccine and Patient Cohort.
      
    Richards NE, Ailsworth SM, Workman LJ, Bortz PS, Patel J, MacCallum M, Canderan G, Murphy D, Muehling LM, McGowan EC, Woodfolk JA, Kadl A, Platts-Mills TAE, Wilson JM.
        
      
    
    Richards NE, et al.
    J Allergy Clin Immunol Pract. 2024 Oct;12(10):2817-2825.e2. doi: 10.1016/j.jaip.2024.06.035. Epub 2024 Jun 27.
    J Allergy Clin Immunol Pract. 2024.
  
  
  PMID: 38944197
  
  
    
  
  
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
      
    Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS, Kocan KM, Fahy JV, Nganga LW, Ronmark E, Cooper PJ, Platts-Mills TA.
        
      
    
    Commins SP, et al.
    J Allergy Clin Immunol. 2011 May;127(5):1286-93.e6. doi: 10.1016/j.jaci.2011.02.019. Epub 2011 Mar 31.
    J Allergy Clin Immunol. 2011.
  
  
  PMID: 21453959
  Free PMC article.
  
    
  
  
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal).
      
    Commins SP, Platts-Mills TA.
        
      
    
    Commins SP, et al.
    Curr Allergy Asthma Rep. 2013 Feb;13(1):72-7. doi: 10.1007/s11882-012-0315-y.
    Curr Allergy Asthma Rep. 2013.
  
  
  PMID: 23054628
  Free PMC article.
  
    
  
  Review.
  
  


  
  
    
  


    
  


        

        
          

        
      
    
  


  


  
    
      
        Cited by
      
      
        
          
  
    
      
  
    
  
  
    
      
        Physiological basis for xenotransplantation from genetically modified pigs to humans.
      
    Peterson L, Yacoub MH, Ayares D, Yamada K, Eisenson D, Griffith BP, Mohiuddin MM, Eyestone W, Venter JC, Smolenski RT, Rothblatt M.
        
      
    
    Peterson L, et al.
    Physiol Rev. 2024 Jul 1;104(3):1409-1459. doi: 10.1152/physrev.00041.2023. Epub 2024 Mar 22.
    Physiol Rev. 2024.
  
  
  PMID: 38517040
  Free PMC article.
  
    
  
  Review.
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        Intrinsic risk factors for alpha-gal syndrome in a case-control study, 2019 to 2020.
      
    Taylor ML, Kersh GJ, Salzer JS, Jones ES, Binder AM, Armstrong PA, Choudhary SK, Commins GK, Amelio CL, Biggerstaff BJ, Beard CB, Petersen LR, Commins SP.
        
      
    
    Taylor ML, et al.
    Ann Allergy Asthma Immunol. 2024 Jun;132(6):759-764.e2. doi: 10.1016/j.anai.2024.01.029. Epub 2024 Feb 8.
    Ann Allergy Asthma Immunol. 2024.
  
  
  PMID: 38341029
  Free PMC article.
  
    
  
  
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        The α-Gal epitope - the cause of a global allergic disease.
      
    Perusko M, Grundström J, Eldh M, Hamsten C, Apostolovic D, van Hage M.
        
      
    
    Perusko M, et al.
    Front Immunol. 2024 Jan 22;15:1335911. doi: 10.3389/fimmu.2024.1335911. eCollection 2024.
    Front Immunol. 2024.
  
  
  PMID: 38318181
  Free PMC article.
  
    
  
  Review.
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabilization.
      
    Elieh-Ali-Komi D, Bot I, Rodríguez-González M, Maurer M.
        
      
    
    Elieh-Ali-Komi D, et al.
    Clin Rev Allergy Immunol. 2024 Feb;66(1):30-49. doi: 10.1007/s12016-024-08981-9. Epub 2024 Jan 30.
    Clin Rev Allergy Immunol. 2024.
  
  
  PMID: 38289515
  Free PMC article.
  
    
  
  Review.
  
  


  
  
    
  


    
  

  
    
      
  
    
  
  
    
      
        Tick bites, IgE to galactose-alpha-1,3-galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha-gal syndrome.
      
    Wilson JM, Erickson L, Levin M, Ailsworth SM, Commins SP, Platts-Mills TAE.
        
      
    
    Wilson JM, et al.
    Allergy. 2024 Jun;79(6):1440-1454. doi: 10.1111/all.16003. Epub 2024 Jan 9.
    Allergy. 2024.
  
  
  PMID: 38193233
  
  
    
  
  Review.
  
  


  
  
    
  


    
  


        

        
          

        
      
    
  


  
  
    
      References
    
    

  

  
    
      
        




  
    
      
        
          
            Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011;12:204–212. doi: 10.1038/ni.2001.
            
              
                
                  -
                  
                    PubMed
                  
                
              
            
          
        
      
    
  

  
    
      
        
          
            Davies DF, Davies JR, Richards MA. Antibodies to reconstituted dried cow’s milk protein in coronary heart disease. J Atheroscler Res. 1969;9:103–107.
            
              
                
                  -
                  
                    PubMed
                  
                
              
            
          
        
      
    
  

  
    
      
        
          
            Constantinides P. Mast cells and susceptibility to experimental atherosclerosis. Science. 1953;117:505–506.
            
              
                
                  -
                  
                    PubMed
                  
                
              
            
          
        
      
    
  

  
    
      
        
          
            Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007;13:719–724. doi: 10.1038/nm1601.
            
              
                
                  -
                  
                    PubMed
                  
                
              
            
          
        
      
    
  

  
    
      
        
          
            Wang J, Cheng X, Xiang MX, et al. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011;121:3564–3577. doi: 10.1172/JCI46028.
            
              
                
                  -
                  
                    PMC
                  
                
              
            
              
                
                  -
                  
                    PubMed
                  
                
              
            
          
        
      
    
  


      
      
        
        

      
    
  

  
    
  


  

  
  
    
      
        Publication types
      

      
    
  


  
  
    
      
        MeSH terms
      

      
    
  


  
  
    
      
        Substances
      

      
    
  


  

  

  



  
  

  


  
    
      
        Grants and funding
      
      
          T32 AI007496/AI/NIAID NIH HHS/United States
        
          P01 HL136275/HL/NHLBI NIH HHS/United States
        
          R01 HL107490/HL/NHLBI NIH HHS/United States
        
          R01 AI020565/AI/NIAID NIH HHS/United States
        
          P01 HL055798/HL/NHLBI NIH HHS/United States
        
          R01 HL136098/HL/NHLBI NIH HHS/United States
        
          K23 HL093118/HL/NHLBI NIH HHS/United States
        
          R37 AI020565/AI/NIAID NIH HHS/United States
        
          R01 AI135049/AI/NIAID NIH HHS/United States
        
          K08 AI085190/AI/NIAID NIH HHS/United States
        
    
  


  
  
    
      LinkOut - more resources
    

    Full Text Sources
                    Atypon
                  
                    Europe PubMed Central
                  
                    Ovid Technologies, Inc.
                  
                    PubMed Central
                  Other Literature Sources
                    scite Smart Citations
                  Medical
                    MedlinePlus Health Information
                  
  




    
  


    

    

  