Reproducibility Project: Cancer Biology
Reproducibility Project: Cancer Biology


                            
            
            
                        
            
            
            

                
    
  

    
        
        
        
        
        
        
        
        
        
        
        
    


      
        
          Edited by
          Roger J Davis et al.
        
          
      

    



  

  
    

      Investigating reproducibility in preclinical cancer research.

      

  



    






  


    

    

        Views 48,076


    




    
    

                
        
        

            
            
            
                The Reproducibility Project: Cancer Biology was an initiative to independently replicate selected experiments from a number of high-profile papers in the field of cancer biology. In the end 50 experiments from 23 papers were repeated. The final two outputs from the project recount in detail the challenges the project team encountered while repeating these experiments ('Challenges for assessing replicability in preclinical cancer biology'), and report the results of a meta-analysis that combined the results from all the experiments ('Investigating the replicability of preclinical cancer biology'). The project was a collaboration between the Center for Open Science and Science Exchange.


            
                
    Collection


  
    

    
        Cancer Biology
        Computational and Systems Biology
    

  

  
    A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.
  

  



    
        Cancer Biology
    

  

  
    A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.
  

  



    
        Cancer Biology
    

  

  
    A project to repeat experiments from high-impact papers in cancer biology did not complete all replications, with challenges ranging from mundane reasons to unexpected methodological issues.
  

  



    
        Cancer Biology
    

  

  
    As the final outputs of the Reproducibility Project: Cancer Biology are published, it is clear that preclinical research in cancer biology is not as reproducible as it should be.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: The results in this Replication Study could not be interpreted.
  

  



    
        Cancer Biology
    

  

  
    Editors' Summary: The results in this Replication Study could not be interpreted.
  

  















    
        Cancer Biology
    

  

  
    Results from the Reproducibility Project: Cancer Biology provide a picture of the rate of false positives in cancer preclinical research, but it is still not clear if research in this field is less reproducible than it should be.
  

  







            
        

        

        
            

                

                    
    Related


  
    

    
        Cancer Biology
    

  


  



    
        Cell Biology
        Immunology and Inflammation
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Medicine
    

  


  



    
        Biochemistry and Chemical Biology
        Neuroscience
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Biochemistry and Chemical Biology
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  



    
        Cancer Biology
    

  


  







                

            
            

                  Contributors



      
        
        
            Roger J Davis
            Reviewing Editor
          
      
      
        
        
            Joaquin Espinosa
            Reviewing Editor
          
      
      
        
        
            Michael R Green
            Reviewing Editor
          
      
      
        
        
            Joan Massagué
            Reviewing Editor
          
      
      
        
        
            Duojia Pan
            Reviewing Editor
          
      





            

            

        
    

    


            

                            

            
                              


    

      
        
            
            
            
            
        
      

    
    

      
        
            
            
            
            
        
      

    
    

      
        
            
            
            
            
        
      

    
    

      
        
            
            
            
            
        
      

    




            
        