'Epigenome editor' silences gene that causes deadly brain disorders
‘Epigenome editor’ silences gene that causes deadly brain disorders

        

        
            
        
        
            
                
                    
                        

    
        
            
                NEWS
                27 June 2024
                
            

            

            
                
                
                     Prion diseases are caused by misfolded proteins, but a new tool can stop them forming in mice.
                
            
        
        
            
    
        
            
                
                    Gemma Conroy
                
                
                
                    
                
            
        
    

        
    
    


            
            


        
            
                
                    
                        

                        
                    
                
            

            
                
                    
                    
                

                

                
                    A molecular-editing tool that’s small enough to be delivered to the brain shuts down the production of proteins that cause prion diseases, a rare but deadly group of neurodegenerative disorders.
                    
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                doi: https://doi.org/10.1038/d41586-024-02115-z

            ReferencesNeumann, E. N. et al. Science 384, eado7082 (2024).Article 
    
                    Google Scholar 
                Raymond, G. J. et al. JCI Insight 5, e131175 (2019).Article 
    PubMed 
    
                    Google Scholar 
                Nuñez, J. K. et al. Cell 184, 2503–2519 (2021).Article 
    PubMed 
    
                    Google Scholar 
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