Cloninger suggested that the three original temperaments, novelty seeking, harm avoidance, and reward dependence, was correlated with low basal dopaminergic activity, high serotonergic activity, and low basal noradrenergic activity, respectively. He has argued that "psychological well-being" depends on the development of facets of the three character dimensions, such as autonomy and life purpose from self-directedness, positive relations with others from cooperativeness, and personal growth and self-actualization from self-transcendence. He has also argued that the temperament dimensions are associated with subjective well-being and to some extent with physical health.
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