Many germs can infect or be carried by many more creatures other than humans, or even survive by themselves. They can access you as the last human in multiple ways. For example:
- Insects. Mosquitoes of different species and habitat can spread many different diseases such dengue fever, yellow fever, and Japanese encephalitis. Flies are no better with sleeping sickness, onchocerciasis and many more. Without a functioning society to control insects, this could become a big problem.

- Water. There are waterborne diseases such as Cholera and Nematode infections caused by swallowing contaminated water, food or beverages. This could become worse without humans, since there would be nobody to operate water treatment facilities.

- Animal contact. Contacting with the saliva, blood, urine, or other body fluids of an infected animal can cause diseases such as Rabies.
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