Kidney disease can be caused by many factors, including:

1. Diabetes: High blood sugar levels can damage the kidneys over time.
2. High blood pressure: Uncontrolled hypertension can cause damage to the blood vessels in the kidneys.
3. Inherited conditions: Polycystic kidney disease and other genetic disorders can lead to kidney problems.
4. Glomerulonephritis: Inflammation of the kidney's filtering units can cause kidney damage.
5. Kidney infections: Repeated or severe infections can lead to kidney damage.
6. Obstructions: Kidney stones or enlarged prostate can block the urinary tract, causing kidney damage.
7. Prolonged use of certain medications: Some medications, like nonsteroidal anti-inflammatory drugs (NSAIDs), can harm the kidneys if used for a long time.

Early-stage kidney disease often has no noticeable symptoms. But as the disease progresses, you may experience:

1. Fatigue and weakness
2. Swelling in the feet, ankles, or hands
3. Shortness of breath
4. Nausea and vomiting
5. Loss of appetite
6. Persistent itching
7. Changes in urine output (more or less frequent)
8. Foamy or bloody urine
9. Difficulty concentrating or mental confusion

If you suspect you have kidney disease, it's important to see a healthcare professional for proper diagnosis and treatment. They will likely perform blood and urine tests to assess your kidney function.

Some related conditions or complications of kidney disease include:

1. Anemia: Reduced red blood cell production due to impaired kidney function.
2. Cardiovascular disease: Kidney disease increases the risk of heart disease and stroke.
3. Electrolyte imbalances: Kidney dysfunction can lead to imbalances in potassium, calcium, and phosphorus levels.
4. Bone disease: Kidney disease can cause weakened bones and increased risk of fractures.
5. Kidney failure: Advanced kidney disease may progress to kidney failure, requiring dialysis or a kidney transplant.
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