From the [wiki](https://rainworld.miraheze.org/wiki/Red_Centipede):

Red Centipedes are extremely dangerous: they only appear in hard mode. Here are some tips to fight or avoid them:

- Don't engage in close-quarters combat if you can. If you do, the Centipede's segments are shielded, and the shield must be removed before you can damage a centipede. Furthermore, the segment shields can only be damaged by **spears**, and Red Centipedes don't flinch when the shield is hit, so be careful
- Sneaking around Red Centipedes is also hard because they have sharp hearing and vision. But you can still avoid being spotted by passing by one of their heads quietly, and crouching / crawling as much as possible; they can't see you when in an idle crouch, or when idle on poles and in tunnels
- Ultimately, the best way to handle Red Centipedes is to simply avoid them. Try taking an alternative route, or staying far enough away that they either won't detect you or won't catch up.
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