Ergonomic mice are designed to naturally fit to your hand, and therefore it is possible that they are more comfortable for you. They also improve your posture. An ergonomic mouse places your hand in a natural handshake position and can this way help you reduce muscular strain.

Ergonomic mice also avoid unnecessary pressure on the wrist. Normal mice use tendons and nerves that go through the underside of the wrist. These parts, however, have little natural protection from surrounding tissues. An ergonomic mouse tries to mitigate this, as they try to reduce unwanted muscle activity. Well-designed ergonomic mice ensure less movement and therefore less fatigue.

Ergonomic mice are designed to be better for you hand, so if you don't mind switching to one, you should at least try them. They try to prevent many conditions, such as mouse arm syndrome and carpal tunnel.
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