Yes, but it depends on what you are doing with the dual monitors. The second monitor will certainly consume more system resources. If you are running applications that require many system resources, like playing games at high frame rates and rendering details at high quality, there might be negative impacts like the GPU heating up or increased loading time. However, if you do tasks with less demand on graphics rendering, it should be alright. Considering your GPU is a GTX 1080, as long as it has enough VRAM, there should not be a large impact on performance.
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