Yes, you will need to add a CMD instruction to the Dockerfile to start the Nginx server when the container starts up. Here's an updated version of the Dockerfile that includes the CMD instruction:

```
FROM nginx:latest
COPY index.html /usr/share/nginx/html/index.html
CMD ["nginx", "-g", "daemon off;"]
```

The CMD instruction specifies the command that should be run when the container starts up. In this case, we are using the nginx command to start the Nginx server, and the "-g" option is used to pass a configuration directive to Nginx. The "daemon off;" directive tells Nginx to run in the foreground rather than as a background daemon, which is necessary for the container to keep running.

You do not need an ENTRYPOINT instruction for this simple example, but you could add one if you want to provide additional customization options.
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