Ergonomics in general is targeting the comfort and ease of usage of a device, appliance, or software over a prolonged period of time. The goal is to reduce fatigue, provide as much comfort as possible and reduce the risk of injuries and negative effects on the health of the user. As such an ergonomic mouse is less likely to hurt the user's hand over time, and its usage causes less physical stress even when used for multiple hours. I have to emphasize however, that ergonomics has a subjective factor. There is "no one size fits all" - literally, the hand size or other biological conditions related to the user can yield an ergonomic mouse less pleasant to use than a regular one for that specific person.
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