If packet size exceeds the MTU this will result in packet fragmentation. This introduces overhead and latency to the data transmission in a best case scenario and application failure in the worst case. If any of the fragmented packets are lost the entire original oversized packet must be retransmitted resulting in additional delay and overhead. It is best practice to keep packets within the MTU size. If larger packets are needed you should speak with your network operator to see if jumbo frames can be enabled.
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