Here are five historically significant days that are often considered to be among the most remarkable in human history:

July 4, 1776: The day the United States Declaration of Independence was adopted, declaring the country's independence from the British Empire.

November 11, 1918: The day the armistice was signed, ending World War I.

August 6, 1945: The day the United States dropped an atomic bomb on Hiroshima, Japan, during World War II.

November 22, 1963: The day President John F. Kennedy was assassinated in Dallas, Texas.

September 11, 2001: The day terrorists attacked the World Trade Center in New York City and the Pentagon in Washington, D.C., leading to the deaths of nearly 3,000 people and launching the United States into the War on Terror.

Note that this list is by no means exhaustive and that many other significant days have shaped the course of human history.
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