Alcoholism involves physical dependence on alcohol that leads to compulsive drinking regardless of negative health effects, especially causing physical changes in brain structure and function. Grey area heavy use refers to frequent consumption above recommended levels but below addiction criteria. 

Both conditions impair judgment, coordination, memory and reasoning abilities due to neurotoxic effects of extended ethanol exposure. Both disrupt social functioning in the short and especially the long term dependence, both lead to structural damage in areas controlling learning & behavior regulation. 

The main difference is that alcoholism causes severe impairments, whereas grey area users tend to temporary maintain control over most areas of life except drinking which will lead to inevitable alcholism unless prevented ahead of time.
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