Here a list of what F5 may refer to,

Transportation:
- SpaceX Falcon 5 proposed space launch rocket

Aircraft:
- F 5 Ljungbyhed, a Swedish Air Force training wing
- Caproni Trento F-5, a jet aircraft of the 1950s
- Caproni Vizzola F.5, an Italian fighter aircraft of 1939
- Felixstowe F.5, a 1918 British flying boat
- Fokker F.V, a 1922 Dutch aircraft
- Northrop F-5, a jet light fighter
- F-5 Lightning, a photo-reconnaissance version of the Lockheed P-38 Lightning
- Shenyang F-5, a version of the Chinese Shenyang J-5 jet fighter

Automobiles:
- BYD F5, a Chinese compact sedan
- DKW F5, a German subcompact sedan
- Haval F5, a Chinese compact SUV
- Hennessey Venom F5, an American sports car

Roads and routes:
- F-05 (Michigan county highway)
- Vermont Route F-5, state highway in Vermont

Locomotives:
- LNER Class F5, a class of British steam locomotives

Other:
- F5 (band), a rock band
- F5 (classification), a wheelchair sport classification
- F5 mandolin, a musical instrument
- F5, Inc., a manufacturer of network equipment
- F5 Tower, a skyscraper in Seattle, Washington
- Neutral Bay ferry services in Sydney Australia, known as the F5
- Cosmic Air (IATA airline designator), an airline in Kathmandu, Nepal
- Factor V, a protein of the coagulation system
- Factsheet Five, a magazine sometimes referred as F5
- Faugère F5 algorithm, for computing the Gröbner basis of an ideal of a multivariate polynomial ring
- Nikon F5, a camera
- F5 tornado, the highest intensity rating on the Fujita scale
- F-5, trademark finishing move of American professional wrestler Brock Lesnar
- F5, a function key
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