The frequency of changing the liquid in a water-cooled PC depends on several factors, such as the type of liquid used, the quality of the cooling system, and the operating conditions. In general, it is recommended to change the liquid in a custom water-cooled PC at least once every one to two years. 

If you are using a high-quality coolant and maintaining the system properly, you might be able to extend this interval to three years or more. However, it's essential to monitor the coolant regularly for any signs of degradation, such as discoloration, cloudiness, or the presence of particles. If you notice any of these signs, it's best to change the liquid sooner.

Additionally, if you modify your PC's cooling loop or add new components, it's a good idea to replace the liquid as part of the maintenance process.

Keep in mind that improper maintenance or using low-quality coolant can lead to the formation of algae, bacteria, or corrosion in the cooling system, which can impact the performance and lifespan of your water-cooled PC. Regular maintenance and timely replacement of the coolant are crucial to ensure the longevity and efficiency of your cooling system.
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