The main symptoms of acromegaly vary among subjects, but these will usually appear:

- Enlarged hands, feet and facial features (forehead, chin, lips, nose, even tongue, etc).
- Skin turns coarse, thick and oily. More sweating and more intense body odor.
- Voice roughens/deepens.
- Joint problems: pain, mobility loss, paresthesia...
- Loss of sex drive, irregular periods or erectile disfunction.
- Headaches, sleep difficulties, snoring, sleep apnoea may appear.
- Vision problems.

Besides these common symptoms, people with acromegaly have a higher tendency for diabetes type II, hypertension, heart diseases, arthritis and bowel polyps, among others.
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