It's difficult to predict exactly when the last truly original thought will be had, as it depends on a number of factors that are difficult to accurately forecast, including the rate of technological progress and the rate of population growth.

However, it is worth noting that the human brain is not a completely deterministic system, and there are many factors that can influence the way that neurons fire and interact with each other. This means that even with a limited number of neurons, there is still a vast potential for different patterns of neural activity and therefore a large number of possible brain states.

Additionally, it's worth considering that human creativity and innovation often arise from combining existing ideas in new and unexpected ways. Even if the physical states of the brain were limited, the number of possible combinations of ideas, experiences, and knowledge would still be vast.

Therefore, it is unlikely that we will ever truly "run out" of unique permutation states of the human brain, as long as human beings continue to exist and engage in creative endeavors.
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