C++, C#, Java, and Python differ in many ways. 
For example, the way programs written in each language are executed. C++ code is compiled so that the host machine can run it directly. C# and Java are compiled into byte code that can be executed by a virtual machine for Java JVM and for C# .NET. Python is an interpreter language where the Python interpreter executes each line at runtime. These differences have implications for both speed and compatibility.
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