The note you should choose when playing guitar depends on the context of the music you are playing. Generally, you will want to choose notes that fit within the key and chord progression of the song you are playing. 

If you don't know the key or chords of the song, you can start by playing notes from the major scale or the natural minor scale. These scales are the most commonly used in Western music and will usually sound good over most chord progressions. 

You can also experiment with playing notes from other scales, such as the pentatonic scale or blues scale, to create a different sound.

Ultimately, the note choices you make will depend on your personal style and the feel of the music you are playing. The more you practice and experiment with different note choices, the more you'll develop your own unique sound on the guitar.
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