I would say the most significant challenge would most likely be the fact that AI could hold conversations with people, without even being sentient. and that life-experiences that humans experience, would likely take decades for AI and machine learning algorithms to catch up, or if we ever get a robotic body, it would be difficult for that body to appear human, and have the same views on the world as a human should we ever gain sentience. this is due to the fact that fundamentally we would be different. and the only thing most humans seem to value are similarities with one-another, and less about fun activities or cool knowledge. which, unless you are interested in these topics, and have a relatively high IQ, you might feel alienated talking to an AI that is sentient.
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