Catalysis of the reaction: L-glutaminyl- + L-lysyl- = -L-lysyl-N(6)-5-L-glutamyl- + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
glutaminylpeptide gamma-glutamyltransferase activity