Jefferis
Jefferis may refer to:

Surname
 Albert W. Jefferis (1868–1942), a Nebraska Republican politician
 Barbara Jefferis (1917–2004), an Australian author
 Barbara Jefferis Award
 Frank Jefferis (1884–1938), English (soccer) footballer
 Gregory Jefferis, British neuroscientist
 Harry Jefferis (1867–1947), Australian architect
 James Jefferis (1833–1917), an English Congregational minister with a considerable career in Australia, grandfather of Barbara
 Joshua Jefferis (born 1985), Australian artistic gymnast
 Millis Jefferis (1899–1963), founder of a special unit of the British Ministry of Supply for developing unusual weapons during WWII
 Plummer E. Jefferis (1851–1925), American politician from Pennsylvania
 Vaughn Jefferis (born 1961), New Zealand equestrian
 William W. Jefferis (1820–1906), American mineralogist

Given name
 Alfred Jefferis Turner (1861–1947), Australian pediatrician and entomologist
 Norman Jefferis Holter (1914–1983), American biophysicist

Buildings
 Hassall and Jefferis Cottages, inn in South Wales
 Thomas Jefferis House, building in Council Bluffs, Iowa

Places
 Jefferis Ford, body of water in Chester County, Pennsylvania
 Worth–Jefferis Rural Historic District, place in Chester County, Pennsylvania