D-mannose is a nondigestible sugar that is gaining traction as a potential treatment for urinary tract infections. It potentially exerts its effect by interfering with bacteria adhering to the urinary epithelium.
This systematic review included eight studies, two of which used D-mannose only and six of which combined D-mannose with another treatment. Three were randomized controlled trials and five were cohort studies.
D-mannose appeared to be effective for preventing recurrent urinary tract infections, possibly with similar efficacy as antibiotics. D-mannose was well tolerated and had minimal side effects, the most common of which was diarrhea.
There are mannose receptors in the lining of the urinary tract, which E. coli can bind to using projections on their cell membranes called “lectins”. D-mannose may bind to these receptors first, making it more difficult for bacteria to latch on and propagate, as explained in this study.
Get free weekly updates on what’s new at Examine.
This Study Summary was published on October 6, 2020.
D-mannose ni sukari isiyoweza kumeng'enywa ambayo inapata traction kama matibabu ya uwezekano wa maambukizi ya njia ya mkojo. Inaweza kufanya kazi kwa kuingilia bakteria zinazoshikamana na epithelium ya mkojo. Uchunguzi huo ulijumuisha masomo manane, mawili kati ya hayo yalitumia D-mannose tu na sita kati ya hayo yalitumia D-mannose pamoja na matibabu mengine. Tatu zilikuwa majaribio ya kudhibitiwa kwa nasibu na tano zilikuwa masomo ya kikundi. D-mannose ilionekana kuwa yenye matokeo katika kuzuia maambukizo ya njia za mkojo yanayorudiwa-rudiwa, labda kwa ufanisi sawa na wa viuavijasumu. D-mannose ilivumiliwa vizuri na ilikuwa na athari ndogo za upande, ambazo za kawaida zilikuwa kuhara. Kuna viwakilishi vya mannose katika utando wa njia ya mkojo, ambayo E. coli inaweza kuunganisha kwa kutumia makadirio kwenye utando wao wa seli inayoitwa <unk>lectins<unk>. D-mannose inaweza kuunganisha kwa receptors hizi kwanza, na kufanya kuwa vigumu kwa bakteria kuunganisha na kueneza, kama ilivyoelezwa katika utafiti huu. Kupata bure updates kila wiki juu ya nini ni mpya katika Kuchunguza. Maelezo ya utafiti huu yalichapishwa mnamo Oktoba 6, 2020.