The discovery of the Clock mutant mouse in 1994 and the identification and cloning of the gene underlying the mutation, named Clock, was a landmark finding in the history of the field of mammalian circadian rhythms. Unexpected at the time, the discovery of the Clock mutant animal would eventually lead to an entire new approach to the study and treatment of obesity. The report in 2005 that the Clock mutant animal is obese and shows signs of the metabolic syndrome opened up an entire new field of obesity research. Although still in the early stages of discovery, linking circadian clock genes to energy regulation has clear implications for future studies on body weight regulation at the mechanistic level, as well as for the development of new therapeutic approaches for combatting the epidemic of obesity, as well as metabolic disorders, including diabetes.
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology
Ugunduzi wa panya wa Clock mwaka 1994 na utambulisho na cloning ya jeni ya msingi ya mabadiliko, aitwaye Clock, ilikuwa ni mafanikio muhimu katika historia ya uwanja wa rhythms circadian mamalia. Ugunduzi wa mnyama wa Clock mutant uliongoza kwenye mbinu mpya ya utafiti na matibabu ya unene wa mwili. Ripoti ya mwaka 2005 kwamba mnyama wa Clock mutant ni mnene na anaonyesha dalili za ugonjwa wa metabolic, kufunguliwa uwanja mpya kabisa wa utafiti wa unene. Ingawa bado katika hatua za mwanzo za ugunduzi, kuunganisha jeni za saa ya circadian na udhibiti wa nishati ina athari za wazi kwa masomo ya baadaye juu ya udhibiti wa uzito wa mwili katika kiwango cha utaratibu, na pia kwa maendeleo ya mbinu mpya za matibabu ya kupambana na janga la unene wa kupita kiasi, pamoja na matatizo ya kimetaboliki, ikiwa ni pamoja na kisukari. ASJC Scopus masomo maeneo - General Medicine - General Biochemistry, Genetics na Molecular Biology