Beyond the double helix - your DNA isn't the whole story
[PRESS INVITATION 30 April 2013] Some genes are expressed only in certain cells and at certain times. Ever since David Allis, professor at the Rockefeller University in New York, discovered the workings of a system that controls the genes, the field of epigenetics has exploded. He is now coming to Sweden to hold a lecture at Karolinska Institutet.
The human genome consists of some 40,000 unique genes. All genes are found in all cells of the body, but it is just a small percentage of them that are activated in any one cell type. The whole process is controlled by chromatin, a structure consisting of histone proteins and DNA that packages genes and activates them when required.
"David Allis discovered the first enzyme that modifies histone proteins so that genes can be expressed," says Professor Per Svenningsson of Karolinska Institutet and scientific coordinator of the collaboration. "He has also described how a number of different histone modifications interact in our cells to switch gene expressions on or off. His work has therefore contributed a great deal to our understanding of how genes are normally regulated and how faulty regulation can give rise to disease."
David Allis's research has been of fundamental importance to the development of the field of epigenetics, which describes how the environment affects gene expression. It is also hoped that epigenetic research will one day develop treatments for diseases such as cancer based on the manipulation of chromatin.
The lecture is part of an institutionalized collaboration between the Rockefeller University in the USA and Karolinska Institutet. The Rockefeller University is world renowned for its research and education in the biomedical sciences and has produced no less than 23 Nobel laureates. These so-termed Nicholson Lectures are held annually by scientists from each university in each country. There is also a research exchange programme in place that enables researchers from one university to spend some time working at the other.
Reporters are welcome to attend the lecture:
Beyond the double helix: why your DNA isn't the whole story.
Lecturer: Professor C. David Allis, Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology and Epigenetics, the Rockefeller University, New York.
When: Tuesday 14 May 2013, 5 pm - 6 pm
Where: Nobel Forum, Nobels väg 1, Karolinska Institutet, Campus Solna.
DNA yako si hadithi nzima [Mwaliko wa Waandishi wa Habari Aprili 30, 2013] Baadhi ya jeni huonyeshwa tu katika seli fulani na wakati fulani. Tangu David Allis, profesa katika Chuo Kikuu cha Rockefeller huko New York, alipogundua jinsi mfumo unaodhibiti chembe za urithi unavyofanya kazi, utafiti wa epigenetics umesitawi sana. Sasa anakuja Sweden kutoa hotuba katika Taasisi ya Karolinska. Genome ya binadamu ina jeni 40,000 za kipekee. Jeni zote zinapatikana katika seli zote za mwili, lakini ni asilimia ndogo tu ya zile zinazotumiwa katika aina yoyote ya seli. Utaratibu huu unadhibitiwa na chromatin, muundo unaojumuisha protini za histoni na DNA ambayo huunganisha jeni na kuziamsha inapohitajika. "David Allis aligundua enzyme ya kwanza ambayo hubadilisha protini za histoni ili jeni ziweze kuonyeshwa, "asema Profesa Per Svenningsson wa Taasisi ya Karolinska na mratibu wa kisayansi wa ushirikiano huo. "Amefafanua pia jinsi mabadiliko kadhaa ya histoni yanavyoingiliana katika chembe zetu ili kugeuza usemi wa jeni kuwa juu au chini. Kwa hiyo, kazi yake imechangia sana uelewevu wetu wa jinsi chembe za urithi zinavyoendeshwa kwa kawaida na jinsi udhibiti mbaya wa chembe za urithi unavyoweza kusababisha magonjwa. Utafiti wa David Allis umekuwa muhimu sana kwa maendeleo ya uwanja wa epigenetics, ambayo inaelezea jinsi mazingira yanavyoathiri usemi wa jeni. Pia, kuna matumaini kwamba siku moja utafiti wa epigenetic utaendeleza matibabu ya magonjwa kama vile kansa kwa kutegemea chromatin. Mkutano huo ni sehemu ya ushirikiano wa taasisi kati ya Chuo Kikuu cha Rockefeller nchini Marekani na Taasisi ya Karolinska. Chuo Kikuu cha Rockefeller ni maarufu duniani kwa utafiti wake na elimu katika sayansi ya biomedical na ina zinazozalishwa si chini ya 23 tuzo za Nobel. Mikutano hiyo inayoitwa Mikutano ya Nicholson hufanywa kila mwaka na wanasayansi kutoka kila chuo kikuu katika kila nchi. Pia kuna mpango wa kubadilishana utafiti mahali ambayo inawezesha watafiti kutoka chuo kikuu moja kutumia muda wa kufanya kazi katika nyingine. "Mwanzoni mwa mkutano huo, alitoa hotuba ya ""Beyond the Double Helix: Why Your DNA Isn't the Whole Story.""" "Mwalimu wa utafiti wa maumbile ya binadamu, C. David Allis, Profesa wa Joy na Jack Fishman, na Mkuu wa Maabara ya Biolojia ya Chromatin na Epigenetics, Chuo Kikuu cha Rockefeller, New York.""" Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 14, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013 - Machi 4, 2013