Chromatin structure and function of eukaryotic genomes
The major functions of eukaryotic genomes – the transcription of genes, the replication of the genome and the recognition and repair of DNA damage – are governed by their organisation into chromatin. Chromatin structure is key to converting the genetic blueprint of an organism into a variety of cell type-specific epigenomes. The groups of the Molecular Biology Division at the Biomedical Center (BMC) in Munich are interested in the mechanisms, molecules and fundamental principles that underlie various aspects of chromatin structure and epigenome function. We are interested in how functional states derive from the interplay of opposing principles: those that endow chromatin structures with plasticity and enable a cell to respond to developmental, metabolic and environmental signals, and others, promoting the assembly of lasting, heritable structures that organise chromosomes and define cellular identity.
„The Principal Investigators of ‘Molecular Biology’ at BMC: (from left):Upper row: Philipp Korber, Axel Imhof, Gunnar Schotta, Peter Becker, Ralph Rupp, front row: Catherine Regnard, Rodrigo Villaseñor”
Chromatin: Muundo na kazi ya eukaryotic genomes: kazi kuu ya eukaryotic genomes - transcription ya jeni, replication ya genome na utambuzi na ukarabati wa DNA uharibifu - ni kutawaliwa na shirika lao katika chromatin. Muundo wa chromatin ni muhimu kwa kugeuza muundo wa maumbile ya kiumbe katika epigenomes mbalimbali za aina ya chembe. Katika utafiti wa Biolojia ya Molekuli, watafiti wa Biomedical Center (BMC) huko Munich wamejifunza juu ya utaratibu, molekuli na kanuni za msingi ambazo zina msingi wa mambo mbalimbali ya muundo wa chromatin na kazi ya epigenome. "Tunavutiwa na jinsi hali za kazi zinatokana na mwingiliano wa kanuni zinazopingana: zile ambazo zinawapa muundo wa chromatin na plasticity na kuwezesha seli kujibu ishara za maendeleo, metabolic na mazingira, na nyingine, kukuza mkusanyiko wa muundo wa kudumu, wa urithi ambao hupanga chromosomes na kufafanua utambulisho wa seli. """ "Mchunguzi Mkuu wa ""Biolojia ya Molekuli"" katika BMC: (kutoka kushoto): Safu ya juu: Philipp Korber, Axel Imhof, Gunnar Schotta, Peter Becker, Ralph Rupp, safu ya mbele: Catherine Regnard, Rodrigo Villaseñor"