Acid reflux occurring more than twice a week which causes inflammation of the esophagus is called as GERD. Prilosec is a medication used in the treatment of gastroesophageal reflux disease. Let us see what Prilosec is, know its effectiveness, dosage, side effects in treating GERD.
Gastroesophageal Reflux Disease (GERD) is a chronic digestive disorder which affects the ring muscle located between the esophagus and stomach called as lower esophageal sphincter (LES). Symptoms of GERD include heartburn, a feeling of being too full and trouble in swallowing. It affects people of all ages, including children.
Prilosec for GERD
Prilosec is a brand name for the generic drug, omeprazole. It is used to treat GERD as well as inflammation of esophagus, heartburn, stomach/duodenal ulcers caused by Helicobacter pylori, stomach upset and Zollinger-Ellison syndrome. It is available in tablet, capsule and liquid forms that can be taken orally. It is sometimes used in the form of a combination therapy by combining it with other medications to achieve the desired goal.
Prilosec belongs to a class of drugs called as proton pump inhibitors (PPIs). It decreases the acid produced by proton pumps (enzymes present in the parietal cells of the stomach lining). During acid production the proton pump participates in the final step. It basically blocks the proton pump to produce less acid.
How Effective is Prilosec in Treating GERD?
It is important to know the effectiveness of Prilosec for GERD before using it. Prilosec is very effective in treating gastric acid-related conditions, including:
- Esophagitis/inflammation/erosion of esophagus.
- Gastroesophageal reflux disease.
- Stomach/duodenal ulcers caused by Helicobacter pylori or nonsteroidal anti-inflammatory drugs (NSAIDs).
- Zollinger-Ellison syndrome; in this disease tumors produce excessive stomach acid.
- Prilosec has been proved out to be a safe and effective drug in treating all these conditions.
Dosage of Prilosec
Prilosec is best taken with medical advice, however, it is good to be aware of the dosage of Prilosec when using it.
Dosage for individuals, 17 years and older, initially 20 mg orally once a day before a meal for 4-8 weeks is given. If required, the dosage may be increased to 40 mg per day. For maintenance therapy 10-20 mg per day of Prilosec may be required.
Dosages for ages 2–16 years depends on child’s weight. For a 5-9 kg, 5 mg is taken once per day. For a 10-19 kg, 10 mg is taken once per day and for 20 kg or more 20 mg is taken once per day.
Prilosec is available in the form of capsule, tablets and delayed-release oral suspension. It is available in strengths of 2.5 mg and 10 mg. The dosage of Prilosec is decided by the treating physician and it is important to follow medical advice.
Side Effects of Prilosec
A side effect is an unintended and undesired effect that occurs at normal pharmacological dose. Some of the side effects of Prilosec include the following.
Common Side Effects of Prilosec in Adults Include
Common Side Effects of Prilosec in Children Include
- Stomach pain
Some Serious Side Effects of Prilosec
- Low magnesium levels: Using Prilosec for 3 months or longer may cause low magnesium levels.
- Vitamin B-12 deficiency: Using Prilosec for more than 3 years can make it harder for body to absorb vitamin B-12.
- Severe diarrhea may be caused by a Clostridium difficile infection in intestines.
- Inflammation of stomach lining.
- Bone fractures can be caused due to prolonged use for a year or longer.
- Kidney damage due to prolonged use.
- Cutaneous lupus erythematosus (CLE).
- Systemic lupus erythematosus (SLE).
As a general rule, medications must be taken only with medical consultation. Considering the side effects of Prilosec, it is necessary to seek medical advice if you have the following conditions.
- Liver problems -This drug may change the way liver works. In case of severe liver problems, doctor may decrease the dose.
- Vitamin B-12 deficient -Prilosec decreases the acid amount produced in stomach. Acid of stomach is required for the absorption of vitamin B-12. Your doctor may monitor vitamin B-12 levels, if the drug is taken for more than 3 years and give vitamin B-12 injections, if required.
- Osteoporosis – An increase in the risk of fractures is seen in individuals taking multiple doses of Prilosec every day for a year or longer. These fractures happen more likely in hip, wrist, or spine. If you are already suffering from osteoporosis, there is an increased risk of bone fractures.
- Hypomagnesia patients -Taking this drug for 3 months or more may cause low magnesium levels. Low magnesium levels can be serious. Doctor will monitor the magnesium levels during the treatment and may give supplements if required.
Contraindications of Prilosec
It is also important to note the complications of Prilosec to ensure its effective use without any complications. Prilosec can be harmful for pregnant and nursing women, with risk to their babies. So, consult doctor urgently in case you become pregnant while on this drug.
Do not use over-the-counter Prilosec without the advice of a doctor if having:
- Bloody/black stools.
- frequent chest pains.
- heartburn with wheezing.
- heartburn lasted for more than 3 months.
- stomach pain.
- trouble/pain while swallowing.
- unexplained weight loss.
- vomit looking like blood or coffee grounds.
Prilosec should be avoided with certain medications like Atazanavir and Nelfinavir, Voriconazole, Digoxin, Warfarin, Phenytoin, Cilostazol, Tacrolimus, Methotrexate, Diazepam, Benzodiazepines, Ampicillin esters, Ketoconazole, Mycophenolate mofetil (MMF), Iron salts, Erlotinib and Clopidogrel. There may be other medicines and conditions, in which Prilosec may be contraindicated, hence medical advice is necessary.
It is clear that Prilosec is an effective drug for treating GERD. Do consult your physician before taking this medication.
Matokeo ya reflux ya asidi mara mbili kwa wiki, ambayo husababisha uvimbe wa esophagus, huitwa GERD. Prilosec ni dawa inayotumiwa katika matibabu ya ugonjwa wa reflux ya gastroesophageal. Tazama jinsi Prolactin inavyofanya kazi, athari zake, na athari za athari katika matibabu ya GERD. Gastroesophageal Reflux Disease (GERD) ni ugonjwa wa kudumu wa utumbo unaoathiri misuli ya pete iliyo kati ya tumbo na tumbo inayoitwa sphincter ya chini ya esophageal. Dalili za GERD ni pamoja na kuchoma moyo, hisia ya kuwa kamili sana na shida ya kumeza. Inawaathiri watu wa umri wote, kutia ndani watoto. Prilosec ni jina la bidhaa kwa ajili ya dawa ya generic, omeprazole. Inatumika kutibu GERD, pamoja na uvimbe wa esophagus, kuwaka moyo, matumbo ya tumbo au duodenal, husababishwa na Helicobacter pylori, maumivu ya tumbo na ugonjwa wa Zollinger-Ellison. Inapatikana katika fomu za vidonge, vidonge na umajimaji ambao unaweza kuchukuliwa kwa mdomo. Wakati mwingine hutumiwa katika fomu ya tiba ya mchanganyiko kwa kuunganisha na dawa nyingine ili kufikia lengo linalotakiwa. Prilosec ni moja ya dawa za kulevya zinazojulikana kama Proton Pump Inhibitors (PPI). Inapunguza asidi inayotokezwa na pampu za protoni (enzymes zilizopo katika chembe za parietal za utando wa tumbo). Wakati wa uzalishaji wa asidi pampu ya protoni inashiriki katika hatua ya mwisho. Kwa kweli huzuia pampu ya protoni kutokeza asidi kidogo. Prilosec ni yenye matokeo kadiri gani katika kutibu GERD? Ni muhimu kujua ufanisi wa Prilosec kwa GERD kabla ya kuitumia. Prilosec ni ufanisi sana katika kutibu hali zinazohusiana na asidi ya tumbo, ikiwa ni pamoja na: - Esophagitis / uvimbe / erosion ya esophagus. - Ugonjwa wa reflux ya gastroesophageal. - Mkojo wa tumbo au duodenal unasababishwa na Helicobacter pylori au dawa zisizo za steroid za kupambana na uvimbe (NSAIDs). - Zollinger-Ellison syndrome; katika ugonjwa huu uvimbe hutokeza asidi nyingi ya tumbo. - Prilosec imethibitishwa kuwa dawa salama na yenye ufanisi katika kutibu hali hizi zote. Proliprazole inapaswa kuchukuliwa kwa ushauri wa daktari, lakini ni muhimu kujua kipimo cha dawa wakati wa matumizi yake. Kwa watu wenye umri wa miaka 17 na zaidi, kwanza 20 mg kwa mdomo mara moja kwa siku kabla ya chakula kwa wiki 4-8. Ikiwa inahitajika, kipimo cha dawa inaweza kuongezeka hadi 40 mg kwa siku. Kwa matibabu ya kudumisha, 10-20 mg ya Prilosec kwa siku inaweza kuhitajika. Kiwango cha dawa kwa umri wa miaka 2-16 inategemea uzito wa mtoto. Kwa watu wenye uzito wa kilo 5-9, mg 5 inachukuliwa mara moja kwa siku. Kwa watu wenye uzito wa kati ya 10 na 19 kg, 10 mg inachukuliwa mara moja kwa siku, na kwa watu wenye uzito wa 20 kg au zaidi, 20 mg inachukuliwa mara moja kwa siku. Prilosec inapatikana katika fomu ya capsule, vidonge na kusimamishwa kwa kucheleweshwa kwa mdomo. Inapatikana katika nguvu za 2.5 mg na 10 mg. Kiwango cha Prilosec huamuliwa na daktari anayetibu na ni muhimu kufuata ushauri wa daktari. Madhara ya Prilosec Madhara ni athari zisizotarajiwa na zisizohitajika ambazo hutokea kwa kipimo cha kawaida cha dawa. Baadhi ya athari za upande za Prilosec ni pamoja na zifuatazo. Madhara ya kawaida ya Prolactin katika watoto ni pamoja na maumivu ya tumbo, maumivu ya tumbo, na athari za magnesiamu za chini. - Upungufu wa vitamini B12: Kutumia Prilosec kwa zaidi ya miaka 3 kunaweza kufanya iwe vigumu kwa mwili kufyonza vitamini B12. - Kuanza kuhara kwa kiasi kikubwa kwaweza kusababishwa na maambukizo ya Clostridium difficile katika matumbo. - Uvimbe wa utando wa tumbo. - Mvunjiko wa mifupa waweza kusababishwa na matumizi ya muda mrefu kwa mwaka mmoja au zaidi. - Uharibifu wa figo kutokana na matumizi ya muda mrefu. - Lupus erythematosus ya ngozi (CLE). - Lupus erythematosus ya mfumo (SLE). Kwa kawaida, dawa lazima zitumiwe tu baada ya kushauriana na daktari. Kwa kuzingatia athari za Prolactin, unahitaji kutafuta ushauri wa daktari ikiwa una hali zifuatazo: - Matatizo ya ini - Dawa hii inaweza kubadilisha jinsi ini linavyofanya kazi. Katika kesi ya matatizo makubwa ya ini, daktari anaweza kupunguza kipimo. - Upungufu wa vitamini B12 - Prolactin hupunguza kiasi cha asidi inayotokezwa katika tumbo. Asidi ya tumbo inahitajika kwa ajili ya kunyonya vitamini B-12. Daktari wako anaweza kufuatilia viwango vya vitamini B12 ikiwa dawa hiyo inachukuliwa kwa zaidi ya miaka mitatu na kutoa sindano za vitamini B12 ikiwa inahitajika. - Osteoporosis <unk> Ongezeko la hatari ya kuvunjika huonekana katika watu wanaotumia dozi nyingi za Prilosec kila siku kwa mwaka mmoja au zaidi. Mvunjiko huo huelekea zaidi kutokea kwenye kiuno, mkono, au uti wa mgongo. Ikiwa tayari una ugonjwa wa osteoporosis, kuna hatari kubwa ya kuvunjika kwa mifupa. - Wagonjwa wa hypomagnesia - Kutumia dawa hii kwa miezi 3 au zaidi kunaweza kusababisha viwango vya chini vya magnesium. Kiwango cha chini cha magnesiamu kinaweza kuwa mbaya. Daktari atasimamia viwango vya magnesiamu wakati wa matibabu na anaweza kutoa virutubisho ikiwa inahitajika. Msaada wa Prolactin: Ni muhimu pia kuzingatia matatizo ya Prolactin ili kuhakikisha matumizi yake yenye ufanisi bila matatizo yoyote. Prilosec inaweza kuwa na madhara kwa wanawake wajawazito na wanaonyonyesha, na hatari kwa watoto wao. Kwa hiyo, wasiliana na daktari haraka ikiwa utapata mimba wakati wa kutumia dawa hii. Usitumie Prilosec ya over-the-counter bila ushauri wa daktari ikiwa una: - Damu ya damu au nyeusi. - maumivu ya kifua ya mara kwa mara. - kuchomwa na moyo na kupiga kelele. - maumivu ya moyo kwa zaidi ya miezi mitatu. - maumivu ya tumbo. - shida au maumivu wakati wa kumeza. - kupoteza uzito bila sababu. - kutapika kuangalia kama damu au kahawa msingi. Dawa za dawa za kulevya kama vile Atazanavir, D-Vitamin, D-Diphenoxine, D-Diphenoxine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine, D-Pyridine. Kunaweza kuwa na dawa nyingine na hali, ambayo Prilosec inaweza kuwa contraindicated, kwa hiyo ushauri wa matibabu ni muhimu. Ni wazi kwamba Prilosec ni dawa yenye matokeo ya kutibu GERD. Mshauri daktari wako kabla ya kutumia dawa hii.