Mice exposed to unusually low levels of the placental hormone allopregnanolone in the womb show atypical brain development and autism-like behaviors.
Spectrum: Autism Research News
Brain cells from the cerebellums of mice that model tuberous sclerosis show dampened levels of proteins controlled by FMRP, the protein missing in fragile X syndrome.
Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.
Connections between the cerebellum and brain networks do not seem to contribute substantially to the emergence of autism traits.
Deleting the autism-linked gene CNTNAP2 from mice leads to distinct cellular and electrical changes in the cerebellum, according to two unpublished studies presented virtually today at the 2021 Society for Neuroscience Global Connectome.
People with autism or autism traits may be especially vulnerable to brain aging and cognitive decline, two studies suggest.
Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.
Our staff picks the stories, podcasts and special reports that stood out from the rest this past year.
The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.
Panya waliofunuliwa kwa viwango vya chini sana vya homoni ya placental allopregnanolone katika tumbo la uzazi huonyesha maendeleo ya ubongo yasiyo ya kawaida na tabia kama za autism. Spectrum: Habari za Utafiti wa Autism Chembe za ubongo kutoka cerebellum ya panya ambazo zinaonyesha sclerosis ya tuberosa zinaonyesha viwango vya chini vya protini zinazodhibitiwa na FMRP, protini inayokosekana katika ugonjwa wa X dhaifu. Kufuta chembe za chembe za CHD8 zinazohusiana na ugonjwa wa akili kutoka kwa seli maalum katika ubongo mdogo, eneo muhimu la ubongo kwa harakati, husababisha upungufu wa magari lakini haibadilishi tabia za kijamii katika panya. Ramani zisizo sawa za usemi wa jeni zinaonyesha kwamba baadhi ya jeni zinazohusiana na ugonjwa wa akili zina jukumu tofauti katika ubongo wa panya na binadamu. Uhusiano kati ya ubongo mdogo na mitandao ya ubongo haionekani kuchangia sana kuibuka kwa sifa za ugonjwa wa akili. Kuondoa jeni linalohusiana na autism (CNTNAP2) kutoka kwa panya huongoza kwa mabadiliko tofauti ya seli na umeme katika ubongo mdogo, kulingana na masomo mawili yasiyochapishwa yaliyowasilishwa leo katika Jumuiya ya Neuroscience ya 2021 Global Connectome. Watu wenye ugonjwa wa akili au tabia za ugonjwa wa akili wanaweza kuwa na hatari ya kuzeeka kwa ubongo na kupungua kwa uwezo wa kutambua, utafiti mmoja unaonyesha. Mabadiliko katika POGZ, jeni inayohusiana sana na ugonjwa wa akili, husababisha kutokuwa na usawa wa ishara katika maeneo mengi ya ubongo katika panya, kulingana na masomo mawili mapya. Mfanyakazi wetu huchagua hadithi, podcasts na ripoti maalum ambazo zilijitokeza kutoka kwa wengine mwaka uliopita. "Timu ya Spectrum inasisitiza mada tano ambazo zilitambulisha utafiti wa autism katika 2020: ""utamaduni katika data, matibabu ya jeni, subtyping, mzunguko wa kijamii na mjadala wa ""jeni la autism."""