Myeloproliferative disorders are often considered cancerous blood disorders and have the potential to transform into acute leukaemia. Even if they do not progress to leukaemia, myeloproliferative disorders can still be fatal in their own right, although they often progress slowly – if at all – and many patients may be asymptomatic.
Myeloproliferative disorders result in the production of too many blood cells in the bone marrow. However – unlike leukaemia – where the cells produce are immature and often do not function correctly – in myeloproliferative disorders the cells are mature and function well. However – the overproduction of these cells can lead to problems with production of the remaining types of cells. They can be divided into three main types:
- Too many red cells – polycythaemia vera
- Too many platelets – Essential thrombocythaemia
- Too much fibrous tissue- primary myelofibrosis
Mara nyingi magonjwa ya myeloproliferative huonwa kuwa magonjwa ya damu yenye kansa na yanaweza kugeuka kuwa leukemia kali. Hata kama hawawezi kuendeleza leukemia, myeloproliferative matatizo bado inaweza kuwa na kifo katika haki yao wenyewe, ingawa mara nyingi maendeleo polepole <unk> kama wakati wote <unk> na wagonjwa wengi inaweza kuwa asymptomatic. Matatizo ya myeloproliferative husababisha uzalishaji wa chembe nyingi sana za damu katika uti wa mgongo. Hata hivyo <unk> tofauti na leukemia <unk> ambapo chembe zinazozalishwa hazikomaa na mara nyingi hazifanyi kazi kwa usahihi <unk> katika matatizo ya myeloproliferative chembe ni kukomaa na kufanya kazi vizuri. Hata hivyo <unk> uzalishaji wa ziada wa seli hizi inaweza kusababisha matatizo na uzalishaji wa aina zilizobaki za seli. Wanaweza kugawanywa katika aina kuu tatu: - Seli nyekundu nyingi sana <unk> polycythaemia vera <unk> Platelets nyingi sana <unk> Thrombocythaemia muhimu <unk> Nyuzinyuzi nyingi sana <unk> myelofibrosis ya msingi