A cell therapy that amplifies the immune response of T cells against cancerous tumors was developed by Canadian scientists associated with the Maisonneuve-Rosemont Hospital Research Center (HMR) and the Université de Montréal.
Immunotherapy is a relatively new treatment in which cancer is attacked from within, stimulating the immune system rather than attacking tumors with chemicals.
The work of Dr. Christopher E. Rudd and his colleagues has shown that a protein unknown to date in T cells interacts with the key receptor that recognizes and responds to cancer antigens.
As a result of this discovery, the team created a new form of immunotherapy in which T cells become overactive to enter the tumor and attack.
Modulation of the discovered protein can activate the immune system and destroy the cancer cells.
Christopher E. Rudd
To date, the effectiveness of this new form of immunotherapy against leukemia and certain skin cancers has been tested in animals.
Researchers now want to test this cancer treatment in human subjects in clinical trials.
This discovery is a breakthrough scientific breakthrough because it will have a significant influence on the immune system’s effectiveness in eliminating cancer cells.
Denis-Claude Roy, Scientific and Medical Director of the Center of Excellence in Cell Therapy and the HMR Research Center
If these results are confirmed, the technique will also improve the effectiveness of the new cell therapy (CAR-T cells) recently offered at Hôpital Maisonneuve-Rosemont.
The results of this study have just been published in the prestigious journal Nature (Nouvelle fenêtre)
Brian Jones has been writing and editing at Freeze Wall for over two years, where he has covered everything from E3 to self-driving cars to rocket launches, and everything in between. He previously spent time at the Gadgets 360, Mashable and Tech Radar, earning a Masters degree in communications from the New Jersey Institute of Technology along the way. When not working on his next piece, you might find Brian traveling the world in search of the weird and wonderful. Failing that, he’ll probably be napping.
Tiba ya seli ambayo huongeza majibu ya kinga ya chembe za T dhidi ya uvimbe wa kansa ilitengenezwa na wanasayansi wa Canada wanaohusishwa na Kituo cha Utafiti cha Hospitali ya Maisonneuve-Rosemont (HMR) na Chuo Kikuu cha Montreal. Immunotherapy ni tiba mpya ambayo inashambulia kansa kutoka ndani, kuchochea mfumo wa kinga badala ya kushambulia uvimbe na kemikali. Christopher E. Rudd na wenzake wameonyesha kwamba protini ambayo haijulikani hadi sasa katika chembe za T huingiliana na kiini cha receptor ambacho hutambua na kujibu antigens za kansa. Kwa sababu ya uvumbuzi huu, timu hiyo iliunda aina mpya ya immunotherapy ambayo seli za T huwa na shughuli nyingi sana kuingia kwenye uvimbe na kushambulia. Kupunguza protini hiyo iliyochimbuliwa kunaweza kuamsha mfumo wa kinga na kuharibu chembe za kansa. Christopher Rudd: Kufikia sasa, ufanisi wa aina hii mpya ya immunotherapy dhidi ya leukemia na saratani fulani za ngozi umejaribiwa kwenye wanyama. Sasa watafiti wanataka kujaribu matibabu hayo ya kansa kwa wanadamu katika majaribio ya kliniki. Ugunduzi huu ni mafanikio makubwa ya kisayansi kwa sababu itakuwa na ushawishi mkubwa juu ya ufanisi wa mfumo wa kinga katika kuondoa seli za kansa. "Mkurugenzi wa Sayansi na Matibabu wa Kituo cha Ubora katika Tiba ya Seli na Kituo cha Utafiti cha HMR, Denis-Claude Roy, alisema: ""Ikiwa matokeo haya yatathibitishwa, mbinu hiyo pia itaboresha ufanisi wa tiba mpya ya seli (seli za CAR-T) iliyotolewa hivi karibuni katika Hospitali ya Maisonneuve-Rosemont." "Brian Jones, mwandishi wa jarida la Nature, ameandika na kuhariri ""Frieze Wall"" kwa zaidi ya miaka miwili, ambapo amefunika kila kitu kutoka kwa E3 hadi magari ya kuendesha yenyewe hadi uzinduzi wa roketi na kila kitu kati." Alifanya kazi katika Gadgets 360, Mashable na Tech Radar, na alipata shahada ya uzamili katika mawasiliano kutoka Taasisi ya Teknolojia ya New Jersey. Wakati wa kutofanya kazi kwenye kipande chake kifuatacho, unaweza kumkuta Brian akisafiri ulimwenguni akitafuta ajabu na ya ajabu. Ikiwa hatatenda hivyo, yaelekea ataanza kulala usingizi.