SAM-e is a nutritional supplement that has only been available in the United States for 20 years after it was discovered in Italy in 1952. Although it is only accessible by prescription in Europe to cure ailments including depression and arthritis, Sam-e is gaining popularity among Americans for various health issues.
SAM-e is manufactured in the body from methionine, an amino acid found in wild fish, eggs, sesame seeds, and oats. Our bodies use it to make certain chemicals and manage vital cell processes. Although SAM-e occurs naturally in our bodies, supplement manufacturers create a copy of the molecule for sale.
What Is SAM-e (S-adenosylmethionine)?
SAM-e, also known as s-adenosylmethionine, is created in the brain from methionine, an essential amino acid that helps grow new blood vessels, and adenosine triphosphate (ATP), a source of energy within our cells. It is produced naturally by the body and has been found to affect essential functions in living cells.
S-adenosylmethionine is a crucial participant in the human methylation process, which helps maintain several biochemical processes in the body and is involved with gene expression, DNA repair, cell membrane fluidity, protein, etc., neurotransmitter synthesis, and fat and mineral metabolism.
SAM-e has been linked to many benefits, including improved mood and anxiety relief. According to one review published in the Journal of Psychiatry & Neuroscience, it is involved in over 35 methylation reactions. (1)
SAM-e has numerous metabolic functions throughout the body, and it participates in the synthesis, activation, and disintegration of a variety of molecules, including proteins and hormones.
It raises serotonin turnover and possibly dopamine norepinephrine levels. It's been shown to have analgesic and anti-inflammatory effects while simultaneously enhancing physical function, and it's frequently used to reduce pain while increasing bodily function. (2)
SAM-e is a naturally occurring chemical present in almost all body tissues and fluids. It is involved in a variety of vital activities. For example, it impacts the immune system, cellular membranes and the production and degradation of brain chemicals such as serotonin, melatonin, and dopamine.
It works in tandem with vitamins B9 and B12. So, if you are getting enough folate and vitamin B12, this may diminish SAM-e levels in the body.
SAM-e has been used to treat pain associated with osteoarthritis in several studies. SAM-e has also been studied as a treatment for depression. Researchers have also investigated the use of SAM-e in fibromyalgia and liver disease, and the results were inconclusive.
Many of the initial studies utilized SAM-e intravenously or as an injection. Researchers have recently examined the effects of SAMe taken by mouth. (3)
SAM-e Potential Benefits
Effective as an Antidepressant
S-adenosylmethionine has been shown in several placebo-controlled studies to have antidepressant effects, but the evidence is still uncertain. However, SAM-e levels are typically lower in depressed people than those who don't show symptoms of depression. Therefore it's thought that when used for depression, it may have beneficial effects.
SAM-e has been found to affect several aspects of the pathophysiology of major depressive disorder, according to a comprehensive analysis published in CNS & Neurological Disorders Drug Targets in 2016. In addition, according to several randomized controlled trials, S-adenosylmethionine is superior to placebo and tricyclic antidepressants.
According to the research, SAM-e has shown promise in nonresponsive serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor patients. (4)
According to a 2008 study by researchers in Melbourne, Australia, SAM-e therapy was superior to the placebo among males but not females when treating major depressive disorder. This double-blind, randomized controlled trial suggests that gender may impact the antidepressant effectiveness of SAM-e; male patients experienced more significant therapeutic benefits. (5)
SAM-e has been more effective than a placebo in treating mild-to-moderate depression and just as effective as antidepressants without the adverse side effects (sleeplessness, headaches, and sexual difficulties). Antidepressants also take 6 to 8 weeks to work, but SAMe begins working faster.
SAM-e's exact mechanism of action in lowering sadness is still not fully understood. However, it may work similarly to some antidepressant medications by increasing the amount of serotonin in the brain.
SAM-e May Improve Brain Function
SAM-e is an important molecule that aids in the process of methylation, which supports a variety of biological processes, including the brain. The loss of methyltransferase function, linked to age-related neurodegenerative diseases such as Alzheimer's, is common.
Levels of SAM-e appear to be lower in people with Alzheimer's disease, potentially affecting their metabolism and brain activity. (6)
S-adenosylmethionine also stimulates the action of enzymes involved in the synthesis of glutathione, a potent antioxidant that works within cells. According to studies, decreased glutathione levels might be linked to Alzheimer's and other neurodegenerative diseases. (7)
It's still debatable whether or not S-adenosylmethionine supplements can help with cognitive decline in humans, but some promising animal studies are to consider.
Researchers looked at the effects of SAM-e on cognitive function in mice as determined by maze performance in a study published in PLoS ONE. Maze performance is a mouse's spatial learning and memory test. Researchers found that supplementing with SAM-e improved cognitive performance, especially among folate-deficient mice, based on 13 studies. They discovered that S-adenosylmethionine might enhance spatial memory in people suffering from many dementia types, including Alzheimer's disease. (8)
Mental Health Implications of SAMe
SAM-e appears to be a beneficial therapy for depression, according to five of seven sources. SAM-e can be taken alone or in combination with other antidepressants. Because its adverse effects are less than antidepressants, SAM-e is more easily tolerated by many individuals: It works faster and has no weight gain, sexual dysfunction, drowsiness, or cognitive interference.
SAM-e has been shown in studies to be beneficial for treating mild, moderate, and even severe depression (Brown et al.). It's also been dubbed a "first-line CAM therapy" for mild, moderate, or severe sadness by one prominent researcher (Brown et al.).
Supports Liver Function
SAM-e synthesis is believed to be depressed in individuals with chronic liver disease, and this deficiency may worsen the condition. As a result, it is thought that SAM-e supplementation might be beneficial in treating liver conditions.
SAM-e is thought to be beneficial and safe for treating chronic liver diseases, according to researchers. S-adenosylmethionine appears to help improve liver function. Therefore, it may be used as part of a therapy plan for liver health; nevertheless, according to several studies, it does not improve outcomes or decrease the rate of adverse events in individuals with chronic liver disease.
Overall, further research is required on the primary therapy of liver disease using SAM-e before definitive recommendations can be made. (9)
Sam-e Works as Natural Pain Reliever
SAM-e supplements are famous for their pain-relieving qualities, which is why they're commonly used to treat lower back discomfort, joint problems, PMS symptoms, and abdominal suffering.
Although S-adenosylmethionine has been shown to help with several ailments, research on its pain-relieving abilities is still in its early stages. Some promising research exists. A pilot study in 2013 conducted at the University of California found that children who took oral SAM-e had minor stomach discomfort.
A 1,400-milligrams-per-day course was given to 14 children with functional abdominal pain for two months. SAM-e improved self-pain reports over the treatment period, according to researchers. (10)
Advantages of SAM-e Compared to Prescription Antidepressants
Antidepressants currently available have a delayed onset of action, so mood improvement may not be evident until four to six weeks of daily usage. SAMe, on the other hand, has a rapid onset of action and generally takes only one week to start working.
SAMe has a favorable safety profile, with few side effects and no clinically significant drug interactions when used appropriately. Few side effects are in stark contrast to antidepressants, which frequently have numerous negative interactions.
There is evidence that SAM-e (400mg) twice a day in people not responding to antidepressant therapy improved memory and other cognitive deficits that often accompany sad moods. (11)
Available Forms of SAM-e
SAM-e is available as tablets or capsules, which are more stable and reliable regarding the amount of SAM-e in the pill. They should be kept cool and dry but not refrigerated. Tablets should be kept in a blister package until you're ready to use them.
SAM-e, a precursor to the major neurotransmitters in the brain, and a mix of precursors to the key nervous system chemicals are included in an excellent supplement,Vital Mind.
Possible Drug Interactions
If taking any of the following drugs, you should not take SAM-e without first consulting your doctor.
The risk of getting serotonin syndrome may be higher when SAM-e is taken at the same time as these medicines:
SAM-e may cause adverse effects when combined with antidepressant medications, such as headache, accelerated or irregular heart rate, anxiety, and restlessness.
Many people report experiencing a reduction in depression after using SAM-e. However, many antidepressants, too, boost serotonin levels in the brain. As a result, concerns have emerged over whether combining the two might cause serotonin to get out of control. If you're taking pills for depression or anxiety, please consult with your doctor before taking SAM-e.
The efficacy of this medication for Parkinson's disease may be reduced by SAMe.
Medications for diabetes
The use of SAMe may cause blood sugar to fall and has the potential to enhance the efficacy of diabetes medications, putting you at a higher risk for hypoglycemia.
Risks and Side Effects
The adverse effects of SAM-e are generally uncommon. They are frequently minor complaints such as stomach upset or nausea when they occur. Still, SAM-e has been known to cause adverse side effects, including sleeplessness, anxiety, and nervousness.
S-adenosylmethionine might aggravate manic symptoms. Therefore, it's recommended that individuals with bipolar disorder avoid taking the supplement unless it's under the care of their health care provider.
SAM-e may react with various medicines and nutritional supplements, particularly those that raise serotonin levels, such as L-tryptophan, St. John's wort, and antidepressant medications.
There's also worry that SAM-e encourages the growth of Pneumocystis carinii, a potentially deadly fungal infection that affects immunocompromised persons, such as those with HIV. Although further study is needed on this topic, persons with a compromised immune system should not take S-adenosylmethionine unless advised by their doctor.
There is still a lot to learn about whether SAM-e is safe to take during pregnancy or while breastfeeding. Studies on children taking SAM-e have been done, and there was no observable toxicity in the children who took it. However, it would be best to start your child on SAM-e or any other supplement only after consulting with their pediatrician.
SAM-e, more like a vitamin than medication, is a natural metabolite that the body requires more of as we grow older and sick. SAM-e is generally safe and supported by evidence for the treatment of depression. It's also being studied as a potential neuroprotectant and ADHD therapy. If it weren't for the cost and lack of insurance coverage, it would be preferred to most prescription antidepressants because of their efficacy.
Looking for a quality SAM-e supplement?
Our Vital Mind supplement contains SAM-e and is designed for those looking for a brain supplement that will help them to increase all aspects of their mental performance while maintaining a calm, balanced mood and without any negative effects on sleep.
Our Vital Mind supplement is also part of our Brain Protocol and Brain Protocol+ bundles, which add our Neuro Calm and Magnesium Supplements, which, alongside Vital Mind, act as the yin and yang, are designed to harmonize the rise and fall of alertness, focus, and calm states throughout the day by providing all of the building blocks needed for neuronal signaling.
SAME ni dawa ya kuongeza lishe ambayo imekuwa inapatikana nchini Marekani kwa miaka 20 tu baada ya kugunduliwa nchini Italia mwaka 1952. Ingawa inapatikana tu kwa dawa ya matibabu huko Ulaya kutibu magonjwa ikiwa ni pamoja na unyogovu na ugonjwa wa viungo, Sam'e inapata umaarufu kati ya Wamarekani kwa masuala mbalimbali ya afya. SAME hutengenezwa katika mwili kutoka kwa methionine, amino asidi inayopatikana katika samaki wa mwituni, mayai, mbegu za sesame, na oats. Mwili wetu huitumia kutengeneza kemikali fulani na kusimamia utendaji muhimu wa chembe. Ingawa SAM-e hutokea kwa asili katika miili yetu, wazalishaji wa virutubisho hutengeneza nakala ya molekuli hiyo kwa ajili ya kuuza. SAM-E (S-adenosylmethionine) ni nini? S-adenosylmethionine (SAM) ni amino asidi muhimu ambayo huchangia ukuaji wa mishipa mpya ya damu na adenosine triphosphate (ATP). Inatengenezwa kwa njia ya asili na mwili na imegunduliwa kuwa huathiri kazi muhimu katika chembe zilizo hai. S-adenosylmethionine ni sehemu muhimu katika mchakato wa methylation ya binadamu, ambayo husaidia kudumisha michakato kadhaa ya biochemical katika mwili na inahusika na usemi wa jeni, ukarabati wa DNA, fluidity ya utando wa seli, protini, synthesis ya neurotransmitter, na metabolism ya mafuta na madini. SAME imeunganishwa na faida nyingi, ikiwa ni pamoja na kuboresha hali ya moyo na kupunguza wasiwasi. Kulingana na jarida la Journal of Psychiatry & Neuroscience, ni muhimu katika athari za methylation. SAM-E ina kazi nyingi za kimetaboliki katika mwili wote, na inashiriki katika utengenezaji, uanzishaji, na uharibifu wa molekuli mbalimbali, ikiwa ni pamoja na protini na homoni. Inaongeza mzunguko wa serotonini na labda viwango vya dopamine norepinephrine. Inaonyesha athari za analgesic na anti-inflammatory wakati huo huo kuimarisha utendaji wa mwili, na mara nyingi hutumiwa kupunguza maumivu wakati wa kuongeza utendaji wa mwili. SAME ni kemikali inayopatikana katika karibu tishu zote za mwili. Inahusika katika utendaji mbalimbali muhimu. Kwa mfano, huathiri mfumo wa kinga, utando wa seli na uzalishaji na uharibifu wa kemikali za ubongo kama vile serotonini, melatonini, na dopamini. Inafanya kazi pamoja na vitamini B9 na B12. Ikiwa una folati na vitamini B12 za kutosha, unaweza kupunguza viwango vya SAM-E katika mwili. SAME imekuwa kutumika kutibu maumivu yanayohusiana na osteoarthritis katika masomo kadhaa. SAM-e pia imechunguzwa kama matibabu ya mshuko wa moyo. Watafiti pia wamechunguza matumizi ya SAM-e katika ugonjwa wa fibromyalgia na ugonjwa wa ini, na matokeo hayakuwa na uhakika. Katika utafiti wa kwanza, SAM-E ilitumiwa kwa njia ya mtiririko wa damu au kwa njia ya sindano. Watafiti wamekuwa wakichunguza athari za dawa ya SAME inayotumiwa kwa mdomo. S-adenosylmethionine imeonyeshwa katika masomo kadhaa ya kudhibitiwa na placebo kuwa na athari za antidepressant, lakini ushahidi bado ni usio hakika. Hata hivyo, viwango vya SAM-e kwa kawaida ni vya chini kwa watu walio na mshuko wa moyo kuliko wale ambao hawaonyeshi dalili za mshuko wa moyo. Kwa hiyo inafikiriwa kwamba inapotumiwa kwa ajili ya mshuko wa moyo, inaweza kuwa na matokeo yenye manufaa. "Kulingana na utafiti uliofanywa na utafiti wa utafiti wa ""CNS & Neurological Disorders Drug Targets"" mnamo 2016 na utafiti wa ""CNS & Neurological Disorders Drug Targets"" mnamo 2016 na 2016." Kwa kuongezea, kulingana na majaribio kadhaa ya kudhibitiwa, S-adenosylmethionine ni bora kuliko placebo na dawa za kukandamiza za tricyclic. Kwa mujibu wa utafiti, SAM-E imeonyesha ahadi katika wagonjwa wasio na majibu ya serotonin reuptake inhibitor na serotonin-norepinephrine reuptake inhibitor. Kulingana na utafiti uliofanywa na watafiti huko Melbourne, Australia, matibabu ya SAM-E yalikuwa bora kuliko placebo kwa wanaume lakini sio kwa wanawake wakati wa kutibu ugonjwa mkubwa wa kushuka moyo. Utafiti huu wa kipekee, wa randomized unaonyesha kwamba jinsia inaweza kuathiri ufanisi wa anti-depressant ya SAME, na wagonjwa wa kiume walipata faida kubwa zaidi ya matibabu. "Sama-e imekuwa na ufanisi zaidi kuliko placebo katika kutibu unyogovu wa kiasi kidogo hadi wa wastani na kama ufanisi kama dawa za kukandamiza bila athari mbaya (kutokwa na usingizi, maumivu ya kichwa, na matatizo ya kingono).""" Dawa za kukandamiza pia huchukua wiki 6 hadi 8 kufanya kazi, lakini SAMe huanza kufanya kazi haraka zaidi. Utaratibu halisi wa SAM-e wa kupunguza huzuni bado haujatambuliwa kikamili. Hata hivyo, inaweza kufanya kazi kama dawa fulani za kukandamiza mshuko wa moyo kwa kuongeza kiasi cha serotonini katika ubongo. SAME inaweza kuboresha utendaji wa ubongo: SAME ni molekuli muhimu ambayo husaidia katika mchakato wa methylation, ambayo inasaidia mchakato mbalimbali wa kibiolojia, ikiwa ni pamoja na ubongo. Kupoteza kazi ya methyltransferase, inayohusiana na magonjwa ya neurodegenerative yanayohusiana na umri kama vile Alzheimer' s, ni ya kawaida. Kiwango cha SAM-E kinaonekana kuwa chini kwa watu walio na ugonjwa wa Alzheimer, na inaweza kuathiri kimetaboliki na shughuli za ubongo. S-adenosylmethionine pia huchochea utendaji wa vimeng'enya vinavyohusika katika kutokeza glutathione, kichocheo chenye nguvu cha kuzuia sumu kinachofanya kazi ndani ya chembe. Kulingana na utafiti, viwango vya glutathione vilivyopungua vinaweza kuhusishwa na ugonjwa wa Alzheimer na magonjwa mengine ya neva. Kwa hivyo, bado kuna utata ikiwa virutubisho vya S-adenosylmethionine vinaweza kusaidia kupungua kwa utambuzi kwa wanadamu, lakini masomo ya wanyama ya kuahidi yanapaswa kuzingatiwa. Watafiti walijaribu athari za SAM-E kwenye kazi ya utambuzi katika panya kama ilivyoamuliwa na utendaji wa maze katika utafiti uliochapishwa katika PLoS ONE. Utendaji wa labyrinth ni mtihani wa kujifunza nafasi na kumbukumbu ya panya. Watafiti walipata kwamba kuongeza na SAME iliboresha utendaji wa utambuzi, haswa kati ya panya wenye upungufu wa folate, kulingana na masomo 13. S-adenosylmethionine inaweza kuboresha kumbukumbu ya nafasi kwa watu wanaosumbuliwa na aina nyingi za dementia, ikiwa ni pamoja na ugonjwa wa Alzheimer. Ugonjwa wa akili wa SAME unaonekana kuwa tiba nzuri ya kushuka moyo, kulingana na vyanzo vitano kati ya saba. SAME inaweza kuchukuliwa peke yake au pamoja na dawa nyingine za kukandamiza. Kwa sababu athari zake mbaya ni ndogo kuliko dawa za kukandamiza, SAME huvumiliwa kwa urahisi na watu wengi: Inafanya kazi haraka na haina kuongezeka kwa uzito, dysfunction ya kingono, usingizi, au kuingiliwa kwa utambuzi. Katika utafiti, SAM-e imeonyeshwa kuwa na manufaa katika kutibu unyogovu mwepesi, wa wastani, na hata mkali (Brown et al.). "Tiba ya kwanza ya CAM kwa huzuni ya kiasi au kali, ""aliongeza Brown." Utaratibu wa utunzaji wa ini: Utaratibu wa utunzaji wa ini unaaminiwa kuwa umepunguzwa kwa watu walio na ugonjwa wa ini wa muda mrefu, na upungufu huu unaweza kuzidisha hali hiyo. Kwa sababu hiyo, inadhaniwa kwamba kuongeza SAM-e kunaweza kuwa na manufaa katika kutibu magonjwa ya ini. SAME ni dawa ya kuokoa na kuokoa maisha ya watu na pia ni muhimu kwa matibabu ya magonjwa ya ini, watafiti wanasema. S-adenosylmethionine inaonekana kusaidia kuboresha kazi ya ini. Kwa hivyo, inaweza kutumika kama sehemu ya mpango wa matibabu kwa afya ya ini; hata hivyo, kulingana na masomo kadhaa, haiboresha matokeo au kupunguza kiwango cha matukio mabaya kwa watu walio na ugonjwa wa ini sugu. Kwa ujumla, utafiti zaidi unahitajika juu ya tiba ya msingi ya ugonjwa wa ini kwa kutumia SAM-e kabla ya mapendekezo ya mwisho yanaweza kufanywa. Sam's Eating Supplements ni maarufu kwa ubora wao wa kupunguza maumivu, na kwa hiyo hutumiwa kwa kawaida kutibu maumivu ya mgongo, matatizo ya viungo, dalili za PMS, na maumivu ya tumbo. Ingawa imethibitishwa kwamba S-adenosylmethionine husaidia katika magonjwa kadhaa, utafiti kuhusu uwezo wake wa kupunguza maumivu bado uko katika hatua zake za mapema. Kuna utafiti fulani wenye kuahidi. Utafiti uliofanywa mwaka 2013 na Chuo Kikuu cha California uligundua kuwa watoto waliotumia dawa ya SAME kwa mdomo walikuwa na maumivu madogo ya tumbo. Kwa mfano, dawa ya miligramu 1,400 kwa siku iliandaliwa kwa watoto 14 wenye maumivu ya tumbo kwa miezi miwili. SAM-e iliboresha ripoti za maumivu ya kibinafsi katika kipindi cha matibabu, kulingana na watafiti. Kwa sababu ya athari za dawa za kupunguza unyogovu zinazopatikana kwa sasa, kuboresha hali ya moyo inaweza kuwa wazi hadi wiki nne hadi sita za matumizi ya kila siku. Kwa upande mwingine, SAMe huanza kutenda haraka na kwa kawaida huchukua wiki moja tu kuanza kufanya kazi. SAME ina profile nzuri ya usalama, na athari chache za upande na hakuna mwingiliano wa dawa muhimu kliniki wakati unatumiwa kwa usahihi. Madhara machache ya upande yanatofautiana sana na dawa za kukandamiza, ambazo mara nyingi huwa na mwingiliano mwingi mbaya. Kuna ushahidi kwamba SAM-E (400 mg) mara mbili kwa siku kwa watu ambao hawajibu matibabu ya antidepressant iliboresha kumbukumbu na upungufu mwingine wa utambuzi ambao mara nyingi huambatana na hali ya huzuni. Aina ya SAME inapatikana kama vidonge au vidonge, ambayo ni imara zaidi na ya kuaminika kuhusu kiasi cha SAME katika kidonge. Zipaswa kuhifadhiwa baridi na kavu lakini si kwenye friji. Dawa za kulevya zinapaswa kuhifadhiwa katika kifurushi cha blister hadi uwe tayari kuzitumia. SAME, kiashiria cha neurotransmitters kuu katika ubongo, na mchanganyiko wa kiashiria cha kemikali muhimu za mfumo wa neva, ni pamoja na katika nyongeza bora ya VitalMind. Ikiwa unachukua dawa yoyote yafuatayo, haupaswi kuchukua SAME bila kwanza kushauriana na daktari wako. Hatari ya kupata ugonjwa wa serotonini inaweza kuwa kubwa wakati SAM-E inachukuliwa wakati huo huo na dawa hizi: SAM-E inaweza kusababisha athari mbaya wakati pamoja na dawa za antidepressant, kama vile maumivu ya kichwa, kasi au kawaida ya moyo, wasiwasi, na wasiwasi. Watu wengi wanaripoti kwamba wanapata upungufu wa mshuko wa moyo baada ya kutumia SAM-e. Hata hivyo, dawa nyingi za kukandamiza mshuko wa moyo huongeza kiwango cha serotonini katika ubongo. Kwa hiyo, watu wana wasiwasi kwamba kuchanganya vitu hivyo viwili huenda kukafanya serotonini isidhibitiwe. Ikiwa unachukua dawa za kupunguza wasiwasi au kushuka moyo, tafadhali wasiliana na daktari wako kabla ya kuchukua dawa hii. Ufanisi wa dawa hii kwa ugonjwa wa Parkinson inaweza kupunguzwa na SAMe. Dawa za kisukari: Matumizi ya SAME yanaweza kusababisha sukari ya damu kushuka na ina uwezo wa kuongeza ufanisi wa dawa za kisukari, na kukuweka katika hatari kubwa ya hypoglycemia. Hatari na athari za upande athari mbaya za SAM-e kwa ujumla ni nadra. Mara nyingi ni malalamiko madogo kama vile maumivu ya tumbo au kichefuchefu yanapotokea. Hata hivyo, SAM-e imejulikana kusababisha madhara mabaya, kutia ndani kukosa usingizi, wasiwasi, na wasiwasi. S-adenosylmethionine inaweza kuzidisha dalili za manic. Kwa hivyo, inashauriwa kwamba watu walio na ugonjwa wa bipolar waepuke kuchukua dawa hiyo isipokuwa ikiwa chini ya utunzaji wa mtoa huduma yao ya afya. SAME inaweza kuingiliana na dawa mbalimbali na virutubisho vya lishe, hasa zile zinazoongeza viwango vya serotonini, kama vile L-tryptophan, St. John's wort, na dawa za kukandamiza. Pia kuna wasiwasi kwamba SAM-E huchochea ukuaji wa Pneumocystis carinii, maambukizo ya kuvu ya uwezekano wa kifo ambayo huathiri watu walio na kinga dhaifu, kama wale walio na HIV. Ingawa utafiti zaidi unahitajika juu ya mada hii, watu wenye mfumo wa kinga ulioharibiwa hawapaswi kuchukua S-adenosylmethionine isipokuwa wamependekezwa na daktari wao. Kuna mengi ya kujifunza kuhusu kama SAM-E ni salama kuchukua wakati wa ujauzito au wakati wa kunyonyesha. Utafiti wa watoto waliotumia SAM-E ulionyesha kuwa hakuna athari za sumu zilizoonekana kwa watoto waliotumia dawa hiyo. Hata hivyo, ni bora kuanza mtoto wako juu ya SAM-E au nyongeza nyingine yoyote tu baada ya kushauriana na daktari wao wa watoto. SAME ni vitamini ya asili ambayo mwili wetu unahitaji zaidi tunapozeeka na kuugua. Kwa ujumla, dawa ya SAM-e ni salama na ina ushahidi wa matibabu ya kushuka moyo. Pia inatajwa kama dawa ya neuroprotection na ADHD. Kama haingekuwa kwa gharama na ukosefu wa bima, ingekuwa bora kuliko dawa nyingi za kuua unyogovu kwa sababu ya ufanisi wao. Unatafuta kuongeza ubora wa SAM-e? VitalMind ni bidhaa ya afya ya akili iliyoundwa kwa wale wanaotafuta kuongeza ubongo ambao utawasaidia kuongeza nyanja zote za utendaji wao wa akili wakati wa kudumisha hali ya utulivu, usawa na bila athari yoyote mbaya kwa usingizi. VitalMind ni sehemu ya BrainProtocol na BrainProtocol +, ambayo huongeza Neuro Calm na Magnesium Supplements, ambayo, pamoja na VitalMind, hufanya kazi kama yin na yang, iliyoundwa ili kusawazisha kuongezeka na kuanguka kwa hali ya tahadhari, umakini, na utulivu siku nzima kwa kutoa vitalu vyote vya ujenzi vinavyohitajika kwa ishara ya neuronal.