Scientists have created a tiny, bioengineered 3D model that mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, a pair of rare, devastating neuromuscular diseases.
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US National Center for Advancing Translational Sciences (NCATS)
In this article, Drug Target Review’s Victoria Rees explores a new screening platform that assesses the biological activity of molecules to identify potential drugs. Using their new technique, researchers from the US National Institutes of Health (NIH) identified potential COVID-19 therapeutics.
Researchers have developed a new screening technique called biological activity-based modelling to identify drug candidates.
Wataalamu wa sayansi wametengeneza mfano mdogo wa 3D unaofanana na ugonjwa wa polyneuropathy na ugonjwa wa neuropathy ya multifocal, magonjwa mawili ya nadra ya misuli. "Kama ilivyoelezwa katika makala ya ""Utafiti wa Dawa za Kulevya,"" Victoria Rees, Mkurugenzi wa Kituo cha Kitaifa cha Maendeleo ya Sayansi ya Utafiti wa Dawa za Kulevya, anaelezea jinsi ya kuchunguza shughuli za kibiolojia za molekuli ili kutambua dawa zinazowezekana." Kwa kutumia mbinu hiyo mpya, watafiti kutoka Taasisi ya Kitaifa ya Afya ya Marekani (NIH) wamegundua dawa zinazoweza kutumiwa kutibu ugonjwa wa COVID-19. Watafiti wamebuni mbinu mpya ya kuchunguza inayoitwa muundo wa utendaji wa kibiolojia ili kutambua wagombea wa dawa.