Ian Clark, from the University of East Anglia in the United Kingdom, and colleagues have shown that sulforaphane slows down the destruction of cartilage in joints associated with painful and often debilitating osteoarthritis. They found that mice fed a diet rich in the compound had significantly less cartilage damage and osteoarthritis than those that were not. The study also examined human cartilage cells and cow cartilage tissue, finding that sulforaphane blocks the enzymes that cause joint destruction by stopping a key molecule known to cause inflammation.
Observing that “a [sulforaphane]-rich diet decreases arthritis score in the [destabilization of medial meniscus in the] murine model of osteoarthritis,” the authors conclude that “[sulforaphane] inhibits the expression of key metalloproteinases implicated in osteoarthritis…and blocks inflammation…to protect against cartilage destruction in vitro and in vivo.”
Davidson, R.K., et al. (2013). Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis & Rheumatism. Published online August 27.
—Dr. Bob Goldman
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Dr. Robert M. Goldman MD, PhD, DO, FAASP has spearheaded the development of numerous international medical organizations and corporations. Dr. Goldman has served as a Senior Fellow at the Lincoln Filene Center, Tufts University; as an Affiliate at the Philosophy of Education Research Center, Graduate School of Education, Harvard University, He is Clinical Consultant, Department of Obstetrics and Gynecology, Korea Medical University; and Professor, Department of Internal Medicine at the University of Central America Health Sciences, Department of Internal Medicine. Dr. Goldman holds the positions of Visiting Professor, Udayana University School of Medicine, Indonesia; Visiting Professor, Huazhong University of Science & Technology Tong Ji Medical School, China; Visiting Professor, The Wuhan Institute of Science & Technology, China; Visiting Professor at Hainan Medical College, China; and Visiting Professor, School of Anti-Aging, Aesthetics and Regenerative Medicine, UCSI University, Malaysia. Dr. Goldman is a Fellow of the American Academy of Sports Physicians and a Board Diplomat in Sports Medicine and Board Certified in Anti-Aging Medicine. Dr. Goldman is a Fellow of the American Academy of Sports Physicians and a Board Diplomat in Sports Medicine and Board Certified in Anti-Aging Medicine. He has overseen cooperative research agreement development programs in conjunction with such prominent institutions as the American National Red Cross, the US National Aeronautics and Space Administration (NASA), the Department of Defense, and the FDA’s Center for Devices & Radiological Health.
Dr Goldman was awarded the 2012 LifeTime Achievement Award in Medicine &Science. Dr. Goldman is the recipient of the ‘Gold Medal for Science, the Grand Prize for Medicine, the Humanitarian Award, and the Business Development Award. He received honors from Minister of Sports and government Health officials of numerous nations. In 2001, Excellency Juan Antonio Samaranch awarded Dr. Goldman the International Olympic Committee Tribute Diploma for contributions to the development of sport & Olympism.
In addition, Dr. Goldman is a black belt in karate, Chinese weapons expert, and world champion athlete with over 20 world strength records, he has been listed in the Guinness Book of World Records. Some of his past performance records include 13,500 consecutive situps and 321 consecutive handstand pushups. Dr. Goldman was an All-College athlete in four sports, a three time winner of the John F. Kennedy (JFK) Physical Fitness Award, was voted Athlete of the Year, was the recipient of the Champions Award, and was inducted into the World Hall of Fame of Physical Fitness. Dr. Goldman was awarded the Healthy American Fitness Leader Award from the President’s Council on Physical Fitness & Sports and U.S. Chamber of Commerce. Dr. Goldman is Chairman of the International Medical Commission overseeing sports medicine committees in over 184 nations. He has served as a Special Advisor to the President’s Council on Physical Fitness & Sports. He is founder and international President Emeritis of the National Academy of Sports Medicine and the cofounder and Chairman of the American Academy of Anti-Aging Medicine (A4M). Dr. Goldman visits an average of 20 countries annually to promote brain research and sports medicine programs.
Ian Clark, kutoka Chuo Kikuu cha East Anglia nchini Uingereza, na wenzake wameonyesha kwamba sulforaphane hupunguza uharibifu wa cartilage katika viungo vinavyohusiana na osteoarthritis yenye uchungu na mara nyingi kudhoofisha. Kwa mfano, panya waliolishwa chakula chenye kemikali hiyo walikuwa na kasoro ndogo za cartilage na ugonjwa wa osteoarthritis kuliko wale ambao hawakuwa na kemikali hiyo. Utafiti huo pia ulichunguza chembe za cartilage za binadamu na tishu za cartilage za ng'ombe, na kugundua kwamba sulforaphane huzuia enzymes zinazosababisha uharibifu wa pamoja kwa kusimamisha molekuli muhimu inayojulikana kusababisha uvimbe. Kuona kwamba <unk>a [sulforaphane]-tajiri chakula hupunguza arthritis alama katika <unk>destabilization ya medial meniscus katika <unk> murine mfano wa osteoarthritis, <unk> waandishi kuhitimisha kwamba <unk>[sulforaphane] inazuia usemi wa muhimu metalloproteinases kushiriki katika osteoarthritis... na vitalu kuzuia uvimbe... kulinda dhidi ya uharibifu cartilage in vitro na in vivo. <unk> Davidson, RK., et al. (2013). Sulforaphane inazuia matrix-degrading proteases na inalinda cartilage kutoka uharibifu in vitro na in vivo. Arthritis na Rheumatism. Imechapishwa mtandaoni Agosti 27. <unk>Daktari. Kwa maelezo ya sasa na utafiti juu ya afya na kuzeeka, jiandikishe kwa American Academy of Anti-Aging Medicine e-zine bure katika WorldHealth.net. Robert M. Goldman, MD, PhD, DO, FAASP, amekuwa kiongozi wa maendeleo ya mashirika mengi ya kimataifa ya matibabu na mashirika. Goldman amekuwa mwanachama mwandamizi katika Kituo cha Lincoln Filene, Chuo Kikuu cha Tufts, kama Mshirika katika Kituo cha Utafiti wa Falsafa ya Elimu, Shule ya Ufundi wa Chuo Kikuu cha Harvard, Mshauri wa Kliniki, Idara ya Utoaji na Uuguzi, Chuo Kikuu cha Tiba cha Korea, na Profesa, Idara ya Tiba ya Ndani katika Chuo Kikuu cha Sayansi ya Afya ya Amerika ya Kati. Goldman ni Profesa wa Utafiti katika Chuo Kikuu cha Udayana, Chuo Kikuu cha Utabibu, Chuo Kikuu cha Huazhong, Chuo Kikuu cha Sayansi na Teknolojia, Chuo Kikuu cha Tiba cha Tongji, Chuo Kikuu cha Tiba na Teknolojia cha Wuhan, Chuo Kikuu cha Utabiri na Teknolojia, Chuo Kikuu cha UCSI, Chuo Kikuu cha Anti-Aging, Aesthetics na Tiba ya Regenerative. Goldman ni mwanachama wa Chuo cha Marekani cha Madaktari wa Michezo na Bodi ya Diplomat katika Tiba ya Michezo na Bodi ya Vyeti katika Tiba ya Kupinga-Kuzaa. Goldman ni mwanachama wa Chuo cha Marekani cha Madaktari wa Michezo na Bodi ya Diplomat katika Tiba ya Michezo na Bodi ya Vyeti katika Tiba ya Kupinga-Kuzaa. Ameongoza mipango ya ushirikiano ya utafiti na makubaliano ya maendeleo pamoja na taasisi maarufu kama vile Msalaba Mwekundu wa Kitaifa wa Amerika, Utawala wa Kitaifa wa Anga na Anga wa Marekani (NASA), Idara ya Ulinzi, na Kituo cha Vifaa na Afya ya Radiolojia cha FDA. "Mwanamke huyo alipewa tuzo ya ""Lifetime Achievement Award in Medicine and Science"" mwaka 2012." Goldman ni mpokeaji wa medali ya dhahabu kwa ajili ya sayansi, tuzo kubwa kwa ajili ya dawa, tuzo ya kibinadamu, na tuzo ya maendeleo ya biashara. Alipokea heshima kutoka kwa Waziri wa Michezo na maafisa wa afya wa serikali wa mataifa mengi. "Mwaka 2001, Juan Antonio Samaranch alimpa Goldman ""Diploma ya heshima ya Kamati ya Kimataifa ya Olimpiki"" kwa michango yake katika maendeleo ya michezo na michezo ya Olimpiki." Goldman ni msanii wa karate, mtaalamu wa silaha za China, na mwanariadha wa dunia mwenye rekodi zaidi ya 20 za nguvu za dunia. Katika rekodi zake za zamani, ameweka rekodi ya sit-up 13,500 na push-up 321 za kusimama kwa mikono. "Alishinda tuzo ya ""John F. Kennedy"" ya Ubora wa Kimwili mara tatu, alishinda tuzo ya ""Mchezaji wa Mwaka,"" alipokea tuzo ya ""Champions"" na kuingizwa katika Jumba la Utukufu la Dunia la Ubora wa Kimwili." "Mwanamke huyo alipewa tuzo ya ""Healthy American Fitness Leader Award"" na Baraza la Rais la Fitness na Michezo na Chama cha Biashara cha Marekani." Goldman ni mwenyekiti wa Tume ya Kimataifa ya Matibabu, ambayo inasimamia kamati za matibabu ya michezo katika nchi zaidi ya 184. Ametumikia kama Mshauri Maalum wa Baraza la Rais juu ya Afya ya Kimwili na Michezo. Yeye ni mwanzilishi na Rais Emeritus wa Kimataifa wa Chuo Kikuu cha Tiba ya Michezo na mwanzilishi mwenza na Mwenyekiti wa Chuo cha Amerika cha Anti-Aging Medicine (AAM). Goldman anatembelea nchi 20 kila mwaka ili kuendeleza utafiti wa ubongo na mipango ya matibabu ya michezo.