WHAT IS IT?
The immunoglobulin used in intravenous immunoglobulin (IVIg) is prepared from the pooled plasma from about 8000 blood donors. Plasma purification includes steps to remove viruses. Donors at risk for transfusion-related viruses are excluded and IVIg consists almost entirely of IgG with traces of IgM, IgA and soluble plasma factors including cytokines. Its initial use was as replacement therapy in hypogamma-globulinaemia. Its success in treating autoimmune thrombocytopenic purpura led to its use in other immune-mediated diseases.
HOW DOES IT WORK?
We do not really know. There are many proposed mechanisms. Different, possibly multiple, mechanisms may apply in different diseases (Fig. 1).
WHO NEEDS IT?
Guillain–Barré Syndrome (GBS) and Kawasaki disease are the only neurological conditions licensed for IVIg treatment in the United Kingdom. The strength of the evidence for the use of IVIg in other neurological conditions varies. Consensus does not exist. Tables 1, 2 and 3
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Ni Nini? Immunoglobulin ya IVG (Intravenous Immunoglobulin) ni damu ya damu ya wafadhili 8000 wa damu. Usafi wa plasma unatia ndani hatua za kuondoa virusi. Kwa sababu ya hatari ya virusi vinavyohusiana na uhamisho, IVIg ina karibu kabisa IgG na alama za IgM, IgA na sababu za plasma zinazoweza kuyeyuka, pamoja na cytokines. Matumizi yake ya awali yalikuwa kama tiba ya badala katika hypogamma- globulinemia. Mafanikio yake katika kutibu ugonjwa wa purpura ya thrombocythopenic ya autoimmune yalisababisha utumiaji wake katika magonjwa mengine ya kinga. HUFANYAje Kazi? Kwa kweli hatujui. Kuna mifumo mingi iliyopendekezwa. Njia tofauti, labda nyingi, zinaweza kutumika katika magonjwa tofauti (Fig. 1) Ni Nani Anayehitaji? Ugonjwa wa Guillain-Barré (GBS) na ugonjwa wa Kawasaki ni hali pekee za neva zilizoidhinishwa kwa matibabu ya IVIg nchini Uingereza. Uwezo wa ushahidi wa matumizi ya IVIg katika hali nyingine za neva hutofautiana. Hakuna makubaliano. "Tabla ya 1, 2 na 3 Takwimu kutoka Altmetric.com: Ikiwa unataka kutumia tena sehemu yoyote au yote ya makala hii, tafadhali tumia kiungo hapa chini ambacho kitakupeleka kwenye huduma ya ""RightsLink"" ya Kituo cha Ufafanuzi wa Haki za Uandishi." Utaweza kupata bei ya haraka na ruhusa ya papo hapo ya kutumia tena maudhui kwa njia nyingi tofauti.