The use of probiotics has become almost universally recommended. Two new studies advise caution on the blanket use of probiotics. Probiotics are beneficial in some patients but other patients may, unfortunately, have little response and even show adverse reactions to probiotics.
To summarize what we know:
- Stool samples alone do not provide an accurate picture of the interactions between probiotics and the patient’s pre-existing microbiome and their overall health
- Some patient’s microbiota resists colonization with probiotics while others change in response to probiotic ingestion and often in different ways along different points of the GI tract
- Probiotics after antibiotics can impede the microbiome’s return to baseline flora (significance unknown)
- Characteristics of an individual patient and their microbiome can predict probiotics effects in that person
- Using mice as a model for the human microbiome is not very informative or reliable in understanding the effects of probiotics
Probiotics, for a time now, have been recommended haphazardly and the decision to use them should be a medical decision (scientifically weighing the pros and cons), like the decision to use any medication or treatment. It should be a case-by-case decision, taking into account the long-term dysbiosis induced after taking probiotics after antibiotics and the knowledge that currently true indications for probiotics is limited.
What are needed are independently funded, multi-center, blinded, placebo-controlled studies on probiotics. This is a big divergence from manufacturer/pharma-sponsored studies with the currently held belief that probiotics effects are always positive.
These new studies show there is a lot that we do know about probiotics but also a lot we do not. For example, we know probiotics help when treating C. Difficile infection when given with antibiotics but if a person already has a C. Difficile infection, probiotics probably won’t help much.
In the first study, Zmora et at tested a multi-strain probiotic combination in both humans and mice. In the intervention group, 14 patients took the probiotics and 4 took a placebo and the other group received nothing. The study lasted a month. Stool samples were collected at baseline, daily for a week and then weekly for rest of the month of the study.
The findings show that the mucosal colonization patterns that emerged in the GI tract depended on the strain of the probiotic, the region of the body sampled and factors such as gene expression patterns in the gut and baseline microbiota. Further study of the stool did not describe nor predict the probiotic effect.
In the Suez study, three groups of patients each were studied after a seven-day course of Cipro and Flagyl. After the antibiotic course, one group received probiotics bid for 28 days, six received an autologous fecal transplant (taken before antibiotics) and seven had no further treatment. The study showed the patients on probiotics had a delayed microbiome recovery, the significance of which is currently unknown. Although, a persistent dysbiosis of the type induced by probiotics in the study has been linked to developing obesity, cardiometabolic disease and allergies.
In summary, the blanket use of probiotics for non-studied indications, may help in some patients, may do nothing in some patients and potentially harm others.
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features Niv Zmora et al. Cell sept 6, 2018
Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT Jotham Suez et al. Cell Sept 6, 2018
Matumizi ya viungo vya probiotic yamependekezwa karibu ulimwenguni pote. Uchunguzi mpya mbili unashauri tahadhari juu ya matumizi ya probiotics. Probiotics ni muhimu kwa baadhi ya wagonjwa, lakini wagonjwa wengine wanaweza, kwa bahati mbaya, kuwa na majibu kidogo na hata kuonyesha athari mbaya kwa probiotics. Kwa mfano, sampuli za mkojo peke yake hazitoi picha sahihi ya mwingiliano kati ya probiotics na microbiome ya mgonjwa na afya yao ya jumla, wakati wengine wanakabiliwa na athari za probiotics, na mara nyingi kwa njia tofauti katika sehemu tofauti za mfumo wa utumbo, na athari za probiotics zinaweza kuzuia kurudi kwa microbiome kwa msingi (umaana wa kisayansi haujulikani) na sifa za mgonjwa mmoja na microbiome yao zinaweza kutabiri athari za probiotics kwa mtu huyo. "Ili kuamua kwa kila kesi, kuzingatia dysbiosis ya muda mrefu inayosababishwa baada ya kuchukua probiotics baada ya antibiotics na maarifa kwamba kwa sasa dalili za kweli za probiotics ni mdogo. """ Kwa hivyo, utafiti wa msingi wa utafiti wa msingi, unaofadhiliwa na taasisi nyingi, na unaoongozwa na placebo, unafanywa kwa njia ya utafiti wa msingi. Hii ni tofauti kubwa kutoka kwa utafiti unaofadhiliwa na mtengenezaji wa dawa na imani ya sasa ya kuwa athari za probiotics ni chanya kila wakati. Uchunguzi huu mpya unaonyesha kuna mengi ambayo tunajua kuhusu probiotics lakini pia mengi ambayo hatujui. Kwa mfano, tunajua probiotics kusaidia wakati wa kutibu C. Maambukizo magumu wakati kupewa na viuavijasumu lakini kama mtu tayari ana C. Maambukizo magumu, probiotics pengine si kusaidia sana. Katika utafiti wa kwanza, Zmora et al. walijaribu mchanganyiko wa probiotic wa aina nyingi kwa wanadamu na panya. Katika kundi la kuingilia, wagonjwa 14 walichukua probiotics na 4 walichukua placebo na kikundi kingine hakikupata chochote. Utafiti huo ulidumu kwa mwezi mmoja. Sampuli za mkojo zilikusanywa kwa wiki moja kila siku na kisha kila wiki kwa mwezi wote wa utafiti. Matokeo ya utafiti huo yanaonyesha kuwa mifumo ya ukoloni wa mucosa iliyoonekana katika mfumo wa tumbo inategemea aina ya probiotic, eneo la mwili lililochukuliwa na sababu kama vile mifumo ya maonyesho ya jeni katika matumbo na microbiota ya msingi. Uchunguzi zaidi wa matope haukufafanua wala kutabiri athari ya probiotic. Katika utafiti wa Suez, kila kikundi cha wagonjwa kimechunguzwa baada ya matibabu ya siku saba ya Cipro na Flagyl. Baada ya matibabu ya antibiotics, kikundi kimoja kilipokea probiotics kwa siku 28, kikundi cha sita kilipokea transplant ya autologous fecal (iliyochukuliwa kabla ya antibiotics) na kikundi cha saba hakikuwa na matibabu zaidi. Utafiti huo ulionyesha kuwa wagonjwa waliopokea probiotics walikuwa na urejesho wa microbiome uliocheleweshwa, umuhimu wake kwa sasa haujulikani. Ugonjwa wa dysbiosis unaosababishwa na probiotics umeunganishwa na ugonjwa wa kunenepa kupita kiasi, ugonjwa wa moyo na allergies. Kwa muhtasari, matumizi ya kawaida ya probiotics kwa dalili zisizochunguzwa inaweza kusaidia kwa baadhi ya wagonjwa, inaweza kufanya chochote kwa baadhi ya wagonjwa na uwezekano wa kuharibu wengine. Ubinafsi Gut Mucosal Colonization Upinzani kwa Empiric Probiotics Ni Kuhusishwa na Unique Host na Microbiome Features Niv Zmora et al. "Kutoka kwa utafiti wa ""Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT"" na ""Jotham Suez et al.""" Simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu ya simu