Consuming Too Much Sugar
High fructose consumption has been linked to increased uric acid.
- HFCS is the sweetener of choice in soft drinks and many processed foods.
- High fructose consumption increases body weight, one of the highest risk factors for raised uric acid levels and gout.
Type 2 Diabetes
According to a 2010 study, the risk of developing diabetes is 26 % higher for those who drink one or more sugary drinks every day.
- Its believed that the regular consumption of sugar sweetened soft drinks increases glucose intolerance and insulin resistance.
- And regular sugary drinks consumption also leads to unwanted weight gain, a high risk factor for type 2 diabetes.
Note: Regular consumption of processed foods containing sugar and refined carbs increases the risk of both conditions in the same way as sugary drinks.
Blood Collection And Laboratory Measurements
After an overnight fast , blood samples were obtained from the participants by means of venipuncture. The samples were then put into an ice-cooled box and transported immediately to the clinical lab at the Department of Biochemistry and Molecular Biology. After centrifugation of blood samples at 3000 rpm for 15 min, the serum was isolated and stored at 20 °C. The serum glucose concentration was measured within 3 h after of blood collection. Serum uric acid , total cholesterol , triglycerides , high-density lipoprotein , serum albumin and total protein were measured by colorimetric methods with a semi-auto biochemistry analyzer . Commercially available diagnostic kits were used for the analysis of the above markers. All measurements were carried out in the clinical lab of the Department according to the standard manufacturers protocols. All laboratory tests were performed by trained graduate level students and precision of the measurements was maintained by regular method calibration with the reference standard.
Sglt2 Inhibitors Reduced Gout Incidence By 11% In Patients With Type 2 Diabetes
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Patients with type 2 diabetes who receive sodium-glucose transport protein 2 inhibitors may have a lower risk for gout compared with those using dipeptidyl peptidase 4 inhibitors, according to data published in JAMA Network Open.
Sodium-glucose transport protein 2 inhibitor administration reduces blood glucose levels and is currently the standard intervention for preventing diabetic kidney disease progression and cardiovascular disease in patients with T2DM,Mu-Chi Chung, MD, of Taichung Veterans General Hospital and National Chung Hsing University, in Taiwan, and colleagues wrote. In a previous trial, different SGLT2 inhibitor medications consistently lowered blood urate levels to 0.3-0.9 mg/dL.
In general, the kidney accounts for approximately 70% of urate elimination, and SGLT2 inhibitors could facilitate glucose transporter 9 excretion of more urine uric acid in exchange for glucose reuptake by increasing glucose concentrations in glomerular filtrate, they added. Because hyperuricemia is accepted as the most important risk factor for development of gout, we speculated whether SGLT2 inhibitor use influences the risk of gout. To date, no association between SGLT2 inhibitor use and the incidence of gout have been established.
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Sugar Sweetened Beverage Consumption Among Adults With Gout Or Type 2 Diabetes
Affiliations Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, Maurice Wilkins Centre for Biodiscovery, Auckland, New Zealand
Affiliation Population Health Directorate, Counties Manukau District Health Board, Auckland, New Zealand
Affiliations Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, Department of Renal Medicine, Waitemata District Health Board, Auckland, New Zealand
Affiliation Department of Medicine, University of Otago, Christchurch, New Zealand
Affiliation Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Affiliation Department of Biochemistry, University of Otago, Dunedin, New Zealand
Having High Blood Pressure
According to a 2014 study hypertension is a major risk factor for gout.
- Approximately 75% of gout patients have high blood pressure.
- And diuretics, taken to combat high blood pressure, can raise uric acid levels in the blood.
- So both the condition and the medicine used to alleviate it increases the risk of gout.
Type 2 Diabetes
A 2015 study concluded that people with high blood pressure have a higher risk of developing type 2 diabetes.
- Around 80% of people with type 2 diabetes have high blood pressure.
- But researchers dont know why theres such a compelling relationship between the two conditions.
- There is a view that inflammation in the body arising from hypertension may play a role.
Read Also: Can I Eat Eggs If I Have Gout
This Is Important News Since Type 2 Diabetes And Gout Have Many Risk Factors In Common To Begin With
People with type 2 diabetes are more likely than average to develop gout, though its not clear if its the diabetes itself or other common risk factors like obesity and hypertension that explain the connection. While lifestyle changes like cutting back on salt and reducing calories in order to lose weight may help a type 2 diabetes patient lower their chances of ending up with gout, it appears that the drugs used to treat diabetes might also tip the balance one way or the other.
According to a new study presented at the 2019 American College of Rheumatology/Association of Rheumatology Professionals Annual Meeting in Atlanta, people with diabetes who took a drug in the GLP1 agonists class were more apt to develop gout compared to those who used an SGLT2 inhibitor instead.
GLP1 agonists are injectible medications that mimic a hormone called glucagon-like peptide-1, which prompts the pancreas to make more insulin. GLP1 agonists include exenatide , liraglutide , and dulaglutide , among others.
SGLT2 inhibitors are oral medications that lower blood sugar by causing more of it to be excreted in urine. They include canagliflozin , dapagliflozin , and empagliflozin .
As expected, patients taking SGLT2 inhibitors were also less likely to develop heart failure.
Read more here about gout comorbidities, including the link between type 2 diabetes and gout.
Risk Factors For Gout And Diabetes
Many of the same things can make your chances of having gout or diabetes go up. You may be more likely to get them if you:
- Are overweight or obese. If you carry extra fat on your body, youâre more likely to have both gout and type 2 diabetes.
- Drink too much alcohol. Moderate amounts of alcohol — one drink a day for women and men over 65 and two for men 65 and younger — may actually lower your chances of getting diabetes. But too much can affect how your pancreas releases insulin, which can lead to type 2 diabetes. More than two drinks a day can also up your odds of gout.
- Have a family history of them. If one of your family members has had gout or diabetes, youâre more likely to get these diseases, too.
- Have other health problems. High cholesterol and high blood pressure are linked to both conditions.
Read Also: All Natural Cures For Gout
Evidence Of Gout And Diabetes
New studies indicate that you have a 20% increased chance of developing diabetes and 40% increases risk of developing kidney disease if you have high levels of uric acid in your blood. A study conducted by Dr. Eswar Krishnan who is an assistant professor of rheumatology at Stanford University researched over a span of 3 years about 2000 men who had gout from a Veterans Administration database and note that none of these men had been diagnosed with neither diabetes nor kidney disease at the beginning of this study.
What they found was that 9% of men with gout who had high levels of uric acid developed diabetes compared to 6% of men whose uric acid levels were in the normal range. For those veterans who had high uric acid levels had a 19% increased risk of developing diabetes.
Another study conducted by the famous gout researcher H.K. Choi and also included Dr. Eswar Krishnan evaluated men with a high cardiovascular risk profile who had gout and the future risk of developing type 2 diabetes. They concluded that those men with gout and a high cardiovascular profile had an increased risk of developing type 2 diabetes later in life and the importance of maintaining an aggressive healthy lifestyle of a proper diet and exercise.
Here is what you can do to lessen your risk of developing diabetes as a gout sufferer:
The Role Of Insulin Resistance
High uric acid doesnt only cause inflammation, though. It can also trigger insulin resistance.
Insulin, a hormone produced in the pancreas, helps control the amount of sugar in your blood. Insulin resistance is when your body doesnt respond well to insulin, causing too much sugar to circulate in your bloodstream.
Physical activity, a moderate weight, and a balanced diet can sometimes reverse insulin resistance. But without treatment, insulin resistance can lead to prediabetes and type 2 diabetes.
Recommended Reading: Is Fish Oil Good For Gout
The Connection Between Gout And Type 2 Diabetes
An estimated eight million people in the United States have gout, according to the Alliance for Gout Awareness. Gout typically affects one joint at a time, with about 1 in 2 attacks beginning in the big toe joint.
Gout is caused by hyperuricemia, which can happen when there is too much uric acid in the body. Uric acid can build up in the joints, fluids, and tissues, which can lead to gout, according to the Centers for Disease Control and Prevention .
Risk factors for gout include being male, having obesity, and chronic conditions such as heart failure, high blood pressure, insulin resistance, metabolic syndrome, poor kidney function, and diabetes, according to the CDC.
Sometimes the pain and symptoms of gout go away temporarily, called remission, but can return suddenly and last days or weeks. Other symptoms include swelling, redness, and heat. Although the condition cant be cured, it can be effectively treated and managed through pain medication, and diet and lifestyle changes.
According to the study authors, SGLT2 inhibitors are already known to reduce uric acid levels, but whether that leads to reducing gout risk is still unclear. To further illuminate the impact, investigators used information from a healthcare claims database that contained individual information on healthcare use, health condition diagnoses, tests and procedures, lab results, and prescriptions filled.
What Is Type 2 Diabetes
Note: I use sugar and glucose interchangeably here.
Type 2 diabetes is the most common form of diabetes , a chronic condition that results from a bodys inability to produce enough or use enough insulin, a hormone that controls blood sugar levels so that the levels never get too high or too low , both of which are very serious, life-threatening conditions.
Your bodys cells need glucose as fuel to produce energy, which glucose comes from carbohydrates in the food you eat. As your food is digested, your blood sugar level rises and triggers the pancreas to release insulin proteins into the bloodstream which attach themselves to your bodys cells and directs them to adsorb the sugar. Cells cannot adsorb glucose directly from the blood. They need that insulin.
But if your body isnt using the insulin properly it means that cells cannot adsorb the sugar which then remains in the blood. And as more food is digested, sugar levels rise even further, and more insulin is released into the bloodstream to deal with it. Its a vicious cycle that can eventually end up overstressing the pancreas and impeding its ability to produce enough insulin.
Common type 2 diabetes symptoms are frequent urination, excessive thirst, tiredness, drowsiness, blurred vision, genital itching, thrush, and slow healing cuts and wounds.
Its interesting to note that some 25% of people with type 2 diabetes are unaware they have it. So if you suffer from any of these symptoms see your doctor right away.
Recommended Reading: How To Get Rid Of Gout Crystals In Foot
Research Design And Methods
The Rotterdam Study has been described in detail elsewhere . Written informed consent was obtained from all participants, and the Medical Ethics Committee of Erasmus Medical Center approved the study. At baseline, serum uric acid was measured and prevalent diabetes cases were excluded . Incident cases of diabetes were diagnosed during follow-up based on the guidelines of the American Diabetes Association and World Health Organizatioin using the information from general practitioners, pharmacies databases, and fasting blood samples that were taken during follow-up examinations . The association was assessed by Cox regression analysis. The population-attributable risk and 95% CIs were calculated with use of the Interactive Risk Assessment Program .
Main Outcomes And Measures
A gout diagnosis was based on the International Classification of Diseases, Ninth Revision, Clinical Modification and the International Statistical Classification of Diseases, Tenth Revision, Clinical Modification . Multiple Cox proportional hazards regression models were used to calculate hazard ratios and 95% CIs.
Recommended Reading: Are Sunflower Seeds Bad For Gout
Subgroup Analyses And Potential Interactions
The association between history of gout and type 2 diabetes did not vary significantly by treatment group, presence of obesity, family history of type 2 diabetes, history of hypertension or presence of the metabolic syndrome . Similarly, the association between serum uric acid levels and type 2 diabetes did not vary significantly by these factors .
Gout And Risk Of Incident Diabetes
In the parallel analysis of gout and risk of hypertension, 2,223 participants reported to have incident diabetes during a mean follow-up of 6.2 years. Compared to participants without gout, those with gout had a 36% increased risk of developing diabetes however, the association vanished after adjustment for BMI and hypertension . A dose-response association between duration of gout and risk of diabetes was observed in the model without adjustment for BMI and hypertension, but not evident after adjustment for those two variables. The association was not substantially different in the 2-year lag analysis .
Recommended Reading: What Can Stop Gout Pain
What To Eat For Gout And Diabetes
If you have gout and diabetes, you may wonder which foods you can eat safely and which ones you need to avoid. It has been confirmed that diet can play a key role in controlling both health conditions. In general, you need to focus on limiting your dietary purine intake and restrict foods high in simple sugar.
Gout and diabetes connection
Several decades ago, gout was thought as a disease in rich people. But over time, it seems that gout can affect anyone, the number of cases for people with gout is now drastically on the rise.
This joint disease is closely related to obesity. And today obesity is a common condition. It can be a risk factor of diabetes , too. This is one of reasons why both diseases can be found together in many cases.
In other words, gouty arthritis and diabetes are different health condition, but they share some same risk factors such as obesity and abusing alcohol.
As well we know, diabetes is a condition of when the body is very poor in controlling the blood sugar level. In diabetic people, their insulin hormone doesnt work efficiently or is not enough produced to the body needs.
And for gouty arthritis, it starts to occur when some uric acids in the blood go to the joint and stay in there. Over time, the deposits of uric acids can form urate crystals. These can be needle-like crystals that can cause inflammation, causing a gout attack.
So, how your diet should go?
Watch on the calories!
Healthy foods for gout and diabetes
Lower Risk For Gout With Sglt2 Inhibitors Vs Glp1 Agonists In Type 2 Diabetes
The following article is a part of conference coverage from the 2019 American College of Rheumatology/Association of Rheumatology Professionals Annual Meeting, being held in Atlanta, Georgia. The team at Rheumatology Advisor will be reporting on the latest news and research conducted by leading experts in rheumatology. Check back for more from the 2019 ACR/ARP Annual Meeting.
ATLANTA Among adults with type 2 diabetes mellitus, sodium-glucose cotransporter 2 inhibitors are associated with a lower rate of gout compared with glucagon-like peptide-1 receptor agonists, according to study results presented at the 2019 American College of Rheumatology/Association of Rheumatology Professionals Annual Meeting, held November 8 to 13, 2019, in Atlanta, Georgia.
Of 111,419 pairs of patients , those newly prescribed an SGLT2 inhibitor showed a lower rate of gout compared with those newly prescribed a GLP1 agonist during the median 177-day follow-up. Heart failure was also lower with SGLT2 inhibitors however, SGLT2 inhibitors and GLP1 agonists were associated with similar rates of cellulitis .
Overall, adults with type 2 diabetes who received an SGLT2 inhibitor had a lower rate of gout compared with those who received a GLP1 agonist.
SGLT2 inhibitors may reduce the risk of developing gout among adults with type 2 diabetes mellitus, though future studies are necessary to confirm this observation, the study researchers concluded.
Recommended Reading: Signs And Symptoms Of Gout In Big Toe
Assessment Of Diabetes And Gout
Specifically, at both follow-up interviews, the participants were asked separately if they had been told by doctors that they had diabetes or gout. If the response was yes, participants were also asked about the age of first diagnosis. For cases of gout, the interviewers also verified with the participants that the diagnosis was based on joint pain and swelling attributed to reported hyperuricemia by their physicians. For cases of diabetes, a previous validation study was conducted in SCHS, and reported a positive predictive value of 99% when comparing self-reported diabetes status to the hospital-based discharge summary database and a supplementary questionnaire about symptoms, diagnostic tests, and medication use. Furthermore, 5.6% of 2,625 randomly selected participants who reported to be free of diabetes had HbA1c 6.5% and thus could be classified as diabetes using the recent diagnostic guidelines. Therefore, 94.4% of participants who reported to be free of diabetes were below the HbA1c cutoff for diabetes. All interviews were tape-recorded and subjected to quality checks.
Kutumia sukari nyingi sana Kutumia fructose nyingi kumehusianishwa na kuongezeka kwa asidi ya uriki. HFCS ni tamu ya uchaguzi katika vinywaji baridi na vyakula vingi kusindika. - Matumizi ya fructose nyingi huongeza uzito wa mwili, mojawapo ya mambo yenye hatari kubwa zaidi ya kuongezeka kwa viwango vya asidi ya uriki na ugonjwa wa gout. Ugonjwa wa kisukari wa aina ya 2 - Kulingana na utafiti uliofanywa mwaka 2010, hatari ya kuugua ugonjwa wa kisukari ni kubwa kwa asilimia 26 kwa wale wanaokunywa kinywaji kimoja au zaidi chenye sukari kila siku. - Inaaminika kwamba matumizi ya kawaida ya vinywaji baridi vyenye sukari huongeza kutoweza kuvumilia glukosi na upinzani wa insulini. Kwa kawaida, kunywa vinywaji vyenye sukari huongeza uzito, jambo ambalo ni hatari kubwa kwa ugonjwa wa kisukari wa aina ya 2. Kwa kawaida, kula vyakula vyenye sukari na wanga huongeza hatari ya ugonjwa huo kama vile kunywa vinywaji vyenye sukari. Mkusanyiko wa Damu na Vipimo vya Maabara Baada ya kufunga usiku kucha, sampuli za damu zilipatikana kutoka kwa washiriki kwa njia ya venipuncture. Vipimo hivyo vilipelekwa kwenye chombo cha barafu na kupelekwa kwenye kituo cha utafiti cha Biolojia ya Molekuli. Baada ya centrifugation ya sampuli za damu kwa 3000 rpm kwa dakika 15, seramu ilitenganishwa na kuhifadhiwa katika 20 ° C. Kiwango cha sukari ya damu kilipimwa ndani ya saa tatu baada ya damu kuchukuliwa. Ugonjwa wa uric acid, cholesterol ya jumla, triglycerides, lipoprotein ya wiani wa juu, albumin ya seramu na protini ya jumla ilipimwa kwa njia za colorimetric na mchambuzi wa biochemistry ya nusu-auto. Vifaa vya utambuzi vilivyopatikana kibiashara vilitumiwa kwa uchambuzi wa alama zilizotajwa hapo juu. Vipimo vyote vilifanywa katika maabara ya kliniki ya Idara kulingana na itifaki za kawaida za wazalishaji. Vipimo vyote vya maabara vilifanywa na wanafunzi waliozoezwa wa ngazi ya kuhitimu na usahihi wa vipimo ulidumishwa kwa utaratibu wa kawaida wa utaratibu na kiwango cha kumbukumbu. Inhibitors ya SGLT2 ilipunguza ugonjwa wa gout kwa 11% kwa wagonjwa wenye ugonjwa wa kisukari wa aina ya 2 Tafadhali jaribu tena baadaye. Kama wewe kuendelea kuwa na tatizo hili tafadhali kuwasiliana na. Wagonjwa wa kisukari cha aina ya 2 ambao hupokea kuzuia protini ya usafirishaji wa sodiamu-glukozi 2 wanaweza kuwa na hatari ya chini ya gout ikilinganishwa na wale wanaotumia kizuizi cha dipeptidyl peptidase 4, kulingana na data iliyochapishwa katika JAMA Network Open. "Utoaji wa kuzuia protini ya usafirishaji wa sodiamu-glukozi 2 hupunguza viwango vya sukari ya damu na kwa sasa ni hatua ya kawaida ya kuzuia maendeleo ya ugonjwa wa figo wa kisukari na ugonjwa wa moyo katika wagonjwa wenye T2DM, ""Mu Chi-Chung, MD, wa Hospitali Kuu ya Veterans ya Taichung na Chuo Kikuu cha Taichung Hsing cha Taiwan, na wenzake waliandika." Katika jaribio la awali, dawa tofauti za kuzuia SGLT2 zilipunguza viwango vya urate ya damu hadi 0.3 mg kwa dL. Kwa ujumla, figo huchukua karibu 70% ya kuondolewa kwa urate, na inhibitors za SGLT2 zinaweza kuwezesha glucose transporter 9 kutolewa kwa asidi ya uric zaidi ya mkojo kwa kubadilishana na reuptake ya glukosi kwa kuongeza viwango vya glukosi katika filtrate ya glomerular. Hyperuricemia ni moja ya sababu za hatari za ugonjwa wa gout, na kwa hivyo, ni muhimu kuzingatia ikiwa dawa ya kuzuia SGLT2 inaweza kuathiri hatari ya ugonjwa huo. Kwa sasa, hakuna uhusiano kati ya matumizi ya SGLT2 inhibitor na matukio ya gout imeanzishwa. "Kama ilivyoelezwa katika utafiti wa ""Uchunguzi wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa wa Ugonjwa.""" Karibu asilimia 75 ya wagonjwa wa gout wana shinikizo la damu la juu. - Na dawa za kuondoa umajimaji, zinazotumiwa kupambana na shinikizo la damu, zaweza kuongeza kiwango cha asidi ya uriki katika damu. - Kwa hiyo hali hiyo na dawa inayotumiwa kuipunguza huongeza hatari ya ugonjwa wa gout. Utafiti wa mwaka 2015 ulionyesha kuwa watu wenye shinikizo la damu la juu wana hatari kubwa ya kupatwa na ugonjwa wa kisukari wa aina ya 2. Karibu asilimia 80 ya watu wenye ugonjwa wa kisukari wa aina ya 2 wana shinikizo la damu la juu. - Lakini watafiti hawajui ni kwa nini kuna uhusiano wa kushawishi kati ya hali hizo mbili. - Kuna maoni kwamba uvimbe katika mwili unaotokana na shinikizo la damu la juu waweza kuwa na sehemu. "Kama wewe ni mgonjwa wa ugonjwa wa kisukari, unaweza kuwa na ""mchanganyiko"" wa aina ya 2 na ugonjwa wa kisukari, na kwa sababu ya sababu nyingine za hatari kama vile ugonjwa wa kisukari, ugonjwa wa kisukari, au ugonjwa wa kisukari." Mabadiliko ya mtindo wa maisha kama vile kupunguza chumvi na kupunguza kalori ili kupunguza uzito yanaweza kusaidia mgonjwa wa kisukari cha aina ya 2 kupunguza uwezekano wa kuishia na gout, lakini inaonekana kwamba dawa zinazotumiwa kutibu kisukari zinaweza pia kugeuza usawa kwa njia moja au nyingine. Kulingana na utafiti uliofanywa na Chuo cha Amerika cha Rheumatology na Chama cha Wataalamu wa Rheumatology, watu wenye ugonjwa wa kisukari ambao walichukua dawa katika darasa la agonists ya GLP-1 walikuwa na uwezekano mkubwa wa kuambukizwa ugonjwa wa gout ikilinganishwa na wale waliotumia kizuizi cha SGLT-2. Agonists ya GLP-1 ni dawa za sindano ambazo huiga homoni inayoitwa glucagon-like peptide-1, ambayo huchochea kongosho kutengeneza insulini zaidi. Agonists GLP1 ni pamoja na exenatide, liraglutide, na dulaglutide, miongoni mwa wengine. Inhibitors za SGLT2 ni dawa za mdomo ambazo hupunguza sukari ya damu kwa kusababisha zaidi ya hiyo kutolewa katika mkojo. Hizi ni pamoja na canagliflozin, dapagliflozin, na empagliflozin. Kama inavyotarajiwa, wagonjwa wanaotumia inhibitors za SGLT2 pia walikuwa na uwezekano mdogo wa kuendeleza kushindwa kwa moyo. Soma zaidi kuhusu ugonjwa wa gout na uhusiano kati ya ugonjwa wa kisukari wa aina ya 2 na gout. Vipengele vya hatari vya ugonjwa wa gout na kisukari Vipengele vingi vya hatari vinaweza kuongeza uwezekano wa kupata ugonjwa wa gout au kisukari. Huenda ukawa na uwezekano mkubwa zaidi wa kupatwa nazo ikiwa: - Una uzito kupita kiasi au unene kupita kiasi. Ikiwa una mafuta mengi mwilini, kuna uwezekano mkubwa wa kuwa na ugonjwa wa kisukari wa aina ya 2. - Kunywa pombe nyingi sana. Kunywa pombe kwa kiasi kidogo - kinywaji kimoja kwa siku kwa wanawake na wanaume wenye umri wa zaidi ya miaka 65 na kinywaji kimoja kwa wanaume wenye umri wa chini ya miaka 65 - kwa kweli kunaweza kupunguza uwezekano wa kupatwa na ugonjwa wa kisukari. Lakini kiasi kikubwa cha sukari kinaweza kuathiri jinsi kongosho linavyotoa insulini, na kusababisha ugonjwa wa kisukari wa aina ya 2. Kunywa zaidi ya vinywaji viwili kwa siku kunaweza pia kuongeza uwezekano wako wa kupatwa na ugonjwa wa gout. - Kuwa na historia ya familia yao. Ikiwa mtu wa familia yako alikuwa na ugonjwa wa gout au kisukari, una uwezekano mkubwa wa kupata magonjwa haya pia. - Wana matatizo mengine ya afya. Cholesterol ya juu na shinikizo la damu la juu zinahusiana na hali zote mbili. Utafiti mpya unaonyesha kuwa kuna uwezekano wa 20% wa kuambukizwa ugonjwa wa kisukari na 40% ya kuambukizwa ugonjwa wa figo ikiwa una viwango vya juu vya asidi uriki katika damu yako. Katika utafiti uliofanywa na Eswar Krishnan, profesa msaidizi wa rheumatology katika Chuo Kikuu cha Stanford, wanaume 2,000 waliopatikana na ugonjwa wa gout walipatikana na ugonjwa wa kisukari na ugonjwa wa figo. Utafiti huo ulionyesha kuwa asilimia 9 ya wanaume walio na ugonjwa wa gout na viwango vya juu vya asidi uriki walipatwa na ugonjwa wa kisukari, ikilinganishwa na asilimia 6 ya wanaume ambao viwango vya asidi uriki vilikuwa katika kiwango cha kawaida. Kwa wale waliokuwa na viwango vya juu vya asidi uriki, hatari ya kupatwa na ugonjwa wa kisukari iliongezeka kwa asilimia 19. Utafiti mwingine uliofanywa na mtaalamu maarufu wa ugonjwa wa gout H. K. Choi na Eswar Krishnan walichunguza wanaume wenye hatari ya ugonjwa wa moyo na damu na hatari ya kuambukizwa ugonjwa wa kisukari aina ya pili. Wanaume walio na gout na kiwango cha juu cha ugonjwa wa moyo na mishipa ya damu wana hatari kubwa ya kuambukizwa ugonjwa wa kisukari wa aina ya 2 baadaye maishani, na umuhimu wa kudumisha mtindo wa maisha wenye afya na chakula sahihi na mazoezi. Kwa hivyo, kama unajua, kuna uwezekano mkubwa wa kuambukizwa ugonjwa wa kisukari na ugonjwa wa gout, na kwa sababu ya athari za insulini, asidi ya uric ya juu inaweza kusababisha uvimbe. Pia inaweza kusababisha upinzani wa insulini. Insulini, homoni inayotengenezwa katika kongosho, husaidia kudhibiti kiasi cha sukari katika damu yako. Insulin upinzani ni wakati mwili wako haina kujibu vizuri kwa insulini, kusababisha sukari sana kuzunguka katika mtiririko wa damu yako. Mazoezi ya kimwili, uzito wa wastani, na lishe yenye usawaziko nyakati nyingine zaweza kurekebisha upinzani wa insulini. Bila matibabu, upinzani wa insulini unaweza kusababisha ugonjwa wa kisukari wa aina ya 2. Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti Gout huathiri sehemu moja ya mguu kwa wakati mmoja, na karibu 1 kati ya 2 huanza katika sehemu ya mguu mkubwa. Ugonjwa wa gout husababishwa na hyperuricemia, ambayo inaweza kutokea wakati kuna asidi ya uric nyingi sana mwilini. Asidi ya uriki inaweza kujilimbikizia katika viungo, umajimaji, na tishu, ambayo inaweza kusababisha gout, kulingana na Vituo vya Kudhibiti na Kuzuia Magonjwa. Vipengele vya hatari vya ugonjwa wa gout ni kuwa mtu wa kiume, kuwa na unene wa kupita kiasi, na hali za muda mrefu kama vile kushindwa kwa moyo, shinikizo la damu la juu, upinzani wa insulini, ugonjwa wa metabolic, utendaji mbaya wa figo, na ugonjwa wa kisukari, kulingana na CDC. Wakati mwingine maumivu na dalili za gout hupungua kwa muda, lakini inaweza kurudi ghafla na kudumu kwa siku au wiki. Dalili nyingine zinatia ndani uvimbe, mwekundu, na joto. Ingawa hali hii haiwezi kutibiwa, inaweza kutibiwa na kusimamiwa kwa ufanisi kupitia dawa za maumivu, na mabadiliko ya lishe na mtindo wa maisha. Kulingana na wataalamu wa utafiti, inhibitors ya SGLT2 tayari inajulikana kupunguza viwango vya asidi uric, lakini kama hiyo inaongoza kwa kupunguza hatari ya gout bado haijulikani. Ili kuelezea athari, watafiti walitumia habari kutoka kwa hifadhidata ya madai ya huduma za afya ambayo ilikuwa na habari ya kibinafsi juu ya matumizi ya huduma za afya, utambuzi wa hali ya afya, vipimo na taratibu, matokeo ya maabara, na dawa zilizojaa. Aina ya 2 ya kisukari: Kwa sababu ya aina hii ya kisukari, sukari na sukari zinaweza kubadilishwa. Aina ya 2 ya kisukari ni aina ya kawaida ya kisukari, hali ya muda mrefu ambayo hutokana na kutokuwa na uwezo wa mwili wa kutengeneza au kutumia insulini ya kutosha, homoni ambayo inadhibiti viwango vya sukari ya damu ili viwango vya sukari visipate kuwa vya juu sana au vya chini sana, na zote mbili ni hali mbaya sana, hatari kwa maisha. Chembe za mwili wako zinahitaji glukosi kama mafuta ili kutengeneza nishati, ambayo glukosi hutoka kwa wanga katika chakula unachokula. Wakati chakula kinapoyeyushwa, kiwango cha sukari ya damu huongezeka na kusababisha kongosho kutolewa kwa protini za insulini katika mtiririko wa damu, ambazo hujiunga na seli za mwili wako na kuelekeza sukari. Chembe haziwezi kunyonya glukosi moja kwa moja kutoka kwa damu. Wanahitaji insulini hiyo. Lakini ikiwa mwili wako hautumii insulini vizuri, inamaanisha kwamba seli haziwezi kunyonya sukari ambayo inabaki katika damu. Kwa sababu chakula kinachotumiwa kwa kiasi kikubwa huongeza kiwango cha sukari, na insulini nyingi hutolewa katika damu ili kukabiliana na tatizo hilo. Ni mzunguko mbaya ambao unaweza kuishia kuimarisha kongosho na kuzuia uwezo wake wa kutengeneza insulini ya kutosha. Dalili za kawaida za ugonjwa wa kisukari wa aina ya 2 ni kukojoa mara kwa mara, kiu kupita kiasi, uchovu, usingizi, maono yasiyoeleweka, kukwaruza kwa viungo vya uzazi, na kupona polepole kwa makovu na majeraha. Kwa kweli, inashangaza kwamba asilimia 25 ya watu walio na ugonjwa wa kisukari wa aina ya 2 hawajui kwamba wana ugonjwa huo. Ikiwa una dalili yoyote ya ugonjwa huu, mwone daktari wako mara moja. Utafiti wa Rotterdam umeelezwa kwa undani mahali pengine. Mkataba wa maandishi ulipatikana kutoka kwa washiriki wote, na Kamati ya Maadili ya Matibabu ya Kituo cha Matibabu cha Erasmus iliidhinisha utafiti huo. Katika msingi, asidi uric seramu ilipimwa na kesi za kisukari zilizopo ziliondolewa. Ugonjwa wa kisukari uligunduliwa kwa kutumia data kutoka kwa madaktari wa jumla, hifadhidata za maduka ya dawa, na sampuli za damu za kufunga zilizochukuliwa wakati wa uchunguzi wa kufuatilia. Ushirikiano huo ulikadiriwa kwa uchambuzi wa kurudi nyuma kwa Cox. Uwezekano wa kuambukizwa kwa watu na 95% ya CIs zilihesabiwa kwa kutumia Programu ya Tathmini ya Hatari ya Maingiliano. Ugonjwa wa gout uligunduliwa kwa kutumia International Classification of Diseases, toleo la tisa, toleo la kliniki na International Statistical Classification of Diseases, toleo la kumi, toleo la kliniki. Mifano ya regression ya hatari nyingi ya Cox ilitumika kuhesabu uwiano wa hatari na 95% CI. Utafiti wa kundi la chini la gout na mwingiliano wa uwezekano: Uhusiano kati ya historia ya gout na ugonjwa wa kisukari wa aina ya 2 haukutofautiana sana kulingana na kikundi cha matibabu, uwepo wa unene wa kupita kiasi, historia ya familia ya ugonjwa wa kisukari wa aina ya 2, historia ya shinikizo la damu au uwepo wa ugonjwa wa kimetaboliki. Kwa upande mwingine, uhusiano kati ya kiwango cha asidi uric ya seramu na ugonjwa wa kisukari wa aina ya 2 haukubadilika sana na sababu hizi. Katika uchambuzi wa sambamba wa gout na hatari ya shinikizo la damu, washiriki 2,223 waliripoti kuwa na ugonjwa wa kisukari wakati wa kufuatilia wastani wa miaka 6.2. Kwa kulinganisha na washiriki wasio na gout, wale walio na gout walikuwa na hatari ya kuongezeka ya 36% ya kuendeleza ugonjwa wa kisukari, hata hivyo, ushirika ulipotea baada ya kurekebisha BMI na shinikizo la damu. Ushirikiano kati ya kipimo na majibu kati ya muda wa gout na hatari ya ugonjwa wa kisukari uligunduliwa katika mfano bila marekebisho ya BMI na shinikizo la damu, lakini haikuwa dhahiri baada ya marekebisho ya vigezo hivyo viwili. Ushirikiano huo haukuwa tofauti sana katika uchambuzi wa kuchelewesha kwa miaka miwili. Utafiti wa Gastroenterology: Jinsi ya Kuondoa Gout na Ugonjwa wa Kisukari - Ikiwa una ugonjwa wa gout na ugonjwa wa kisukari, unaweza kujiuliza ni vyakula gani unavyoweza kula kwa usalama na ni vyapi unavyopaswa kuepuka. Imethibitishwa kwamba lishe yaweza kuwa na fungu muhimu katika kudhibiti hali zote mbili za afya. Kwa ujumla, unapaswa kuzingatia kupunguza ulaji wako wa purini na kupunguza vyakula vyenye sukari nyingi. Ugonjwa wa gout na ugonjwa wa kisukari - Miongo kadhaa iliyopita, gout ilionwa kuwa ugonjwa wa watu matajiri. Kwa sababu ya kuenea kwa ugonjwa wa gout, idadi ya watu wanaougua gout inaongezeka. Ugonjwa huu wa viungo unahusiana sana na kunenepa kupita kiasi. Leo, unene kupita kiasi ni jambo la kawaida. Inaweza pia kuwa sababu ya hatari ya ugonjwa wa kisukari. Hii ni mojawapo ya sababu kwa nini magonjwa yote mawili yanaweza kupatikana pamoja katika visa vingi. Kwa maneno mengine, ugonjwa wa gout na ugonjwa wa kisukari ni hali tofauti za afya, lakini zinashiriki baadhi ya sababu za hatari sawa kama vile unene kupita kiasi na kutumia pombe vibaya. Kama ilivyoelezwa hapo juu, ugonjwa wa kisukari ni hali ambayo mwili huweza kudhibiti kiwango cha sukari ya damu. Kwa watu wenye kisukari, homoni yao ya insulini haifanyi kazi kwa ufanisi au haizaliki vya kutosha kwa mahitaji ya mwili. Ugonjwa wa gouty huanza wakati asidi ya uric katika damu inapoingia kwenye viungo na kukaa ndani. Baada ya muda, madini ya asidi ya uriki yanaweza kufanyiza fuwele za urati. Hii inaweza kuwa fuwele kama sindano ambazo zinaweza kusababisha uvimbe, na kusababisha shambulio la gout. Kwa hiyo, ni jinsi gani chakula chako kinavyopaswa kuwa? Jihadharini na kalori! Ugonjwa wa ugonjwa wa kisukari wa aina ya 2 unaoitwa SGLT2 Inhibitors vs GLP-1 Agonists ni ugonjwa wa kisukari unaosababishwa na ugonjwa wa kisukari wa aina ya 2 unaoitwa SGLT2 Inhibitors vs GLP-1 Agonists. Timu ya Rheumatology Advisor itatoa ripoti juu ya habari za hivi karibuni na utafiti uliofanywa na wataalamu wa kuongoza katika rheumatology. Jifunze zaidi juu ya Mkutano wa Mwaka wa ACR 2019 Kwa watu wazima walio na ugonjwa wa kisukari wa aina ya 2, kuzuia sodium-glucose cotransporter 2 (SGC2) inahusishwa na kiwango cha chini cha gout ikilinganishwa na glucagon-like peptide-1 receptor agonists (GLAPAs), kulingana na matokeo ya utafiti uliowasilishwa katika Mkutano wa Mwaka wa Chuo cha Amerika cha Rheumatology (AAR) uliofanyika Novemba 8-13, 2019 huko Atlanta, Georgia. Kati ya wagonjwa 111,419 waliopokea dawa ya kuzuia SGLT2 walipata kiwango cha chini cha ugonjwa wa gout ikilinganishwa na wale waliopokea dawa ya kuzuia GLP1 wakati wa kufuatilia kwa siku 177 za kati. Ugonjwa wa moyo pia ulikuwa chini na inhibitors SGLT2 hata hivyo, inhibitors SGLT2 na agonists GLP1 walikuwa kuhusishwa na viwango sawa vya cellulitis. Kwa ujumla, watu wazima wenye ugonjwa wa kisukari wa aina ya 2 waliopokea kichocheo cha SGLT2 walikuwa na kiwango cha chini cha gout ikilinganishwa na wale waliopokea agonist ya GLP-1. Inhibitors za SGLT2 zinaweza kupunguza hatari ya kuendeleza gout miongoni mwa watu wazima wenye ugonjwa wa kisukari wa aina ya 2, ingawa utafiti wa baadaye unahitajika ili kuthibitisha uchunguzi huu. "Kama ilivyoelezwa katika makala ya ""Signs and Symptoms of Gout in Big Toe: Assessment of Diabetes and Gout"" (Uchunguzi wa dalili za gout katika kidole kikubwa cha mguu) na ""Uchunguzi wa dalili za gout katika kidole kikubwa cha mguu: Utafiti wa dalili za gout katika kidole kikubwa cha mguu: Uchunguzi wa dalili za gout katika kidole kikubwa: Uchunguzi wa dalili za gout katika kidole kikubwa." Ikiwa jibu lilikuwa ndiyo, washiriki waliulizwa pia kuhusu umri wa utambuzi wa kwanza. Kwa kesi za gout, wahoji pia walithibitisha na washiriki kwamba utambuzi ulitegemea maumivu ya pamoja na uvimbe uliosababishwa na hyperuricemia iliyoripotiwa na madaktari wao. Kwa kesi za kisukari, utafiti wa awali wa uthibitisho ulifanywa katika SCHS na uliripoti thamani nzuri ya utabiri wa 99% wakati wa kulinganisha hali ya kisukari ya kujiripoti na hifadhidata ya muhtasari wa kutolewa kwa hospitali na maswali ya ziada juu ya dalili, vipimo vya utambuzi na matumizi ya dawa. Zaidi ya hayo, 5.6% ya washiriki 2,625 waliochaguliwa kwa nasibu ambao waliripoti kuwa hawana ugonjwa wa kisukari walikuwa na HbA1c 6.5% na hivyo wangeweza kuorodheshwa kama ugonjwa wa kisukari kwa kutumia miongozo ya hivi karibuni ya utambuzi. Kwa hivyo, asilimia 94.4 ya washiriki walioripoti kuwa hawana ugonjwa wa kisukari walikuwa chini ya kiwango cha HbA1c cha ugonjwa wa kisukari. Mahojiano yote yalirekodiwa na kuchunguzwa kwa uangalifu.