Candida albicans is normally a harmless commensal of human beings, but it can cause superficial infections of the mucosa (oral/vaginal thrush) in healthy individuals and (rarely) infections of the skin or nails. It can also become invasive, causing life-threatening systemic and bloodstream infections in immunocompromised hosts, where the mortality rate can be as high as 50 %. It is the most common cause of serious fungal infection and is a common cause of nosocomial infections in hospitals. Some strains have been recognized that are resistant to azoles or echinocandins, which are the first-line antifungals for treatment of C. albicans infections.
Bibliographical noteFunding information
The authors received funding support from Wellcome Trust (086827, 075470, 101873 and 200208) and the MRC Centre for Medical Mycology (N006364/1).
We thank Prashant Sood for help with the graphical abstract figure.
- immune response
- drug resistance
- candida albicans
- medical mycology
Candida albicans ni kawaida harmless commensal ya binadamu, lakini inaweza kusababisha maambukizi ya uso wa mucosa (oral-vaginal thrush) katika watu wazima na (kwa nadra) maambukizo ya ngozi au misumari. Inaweza pia kuwa ya uvamizi, kusababisha vitisho vya maisha vya mfumo na mtiririko wa damu katika majeshi yenye kinga iliyoharibiwa, ambapo kiwango cha vifo kinaweza kuwa juu kama 50%. Ni sababu ya kawaida ya maambukizo makubwa ya kuvu na ni sababu ya kawaida ya maambukizo ya nosocomial katika hospitali. Aina fulani za vimelea ni sugu kwa azole au echinocandins, ambayo ni antifungals ya mstari wa kwanza kwa ajili ya matibabu ya maambukizo ya C. albicans. "Makala ya utafiti wa utafiti wa ""Uchunguzi wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti wa Utafiti." Tunamshukuru Prashant Sood kwa msaada wake na takwimu ya picha ya picha. - majibu ya kinga - upinzani wa dawa - candida albicans - mycology ya matibabu