Molecular weight and size are two key properties of all macromolecules including biologically important and synthetic polymers. Performance and processability are directly related to these parameters.
Why Molecular Weight Matters
Molecular weight is critical property of all macromolecules. Example application areas are manufacturing of biopharmaceuticals and pharmaceuticals and polymer research. In the biopharmaceutical manufacturing industry, development scientists need to be able to correlate particle size to molecular weight in order to determine the proper MWCO (molecular weight cutoff) specification for ultrafiltration processing of biopharmaceuticals. If the correct MWCO is not determined, the cost of mistakes can easily add up to hundreds of thousands of dollars per lost batch.
Another important industry that uses molecular weight is the pharmaceutical industry. Here, the proper molecular weight of the final drug is tracked by QC to assure that drugs are in the correct dosage range so as to avoid either being ineffective or creating an overdose event in use. In these industries, molecular weight is measured across R&D into production and also during quality control.
In polymer science, the molecular weight of a newly synthesized polymer is often measured by static light scattering. The vast majority of useful properties of new materials are related to the chain length of polymeric precursors, as well as the physical dimensions occupied by such chains. These measurements are essential for the production of performance materials.
Our BI-MwA can either be used as a standalone instrument or can be coupled with a GPC instrument. Options are available for both flow or batch mode. Our MwA instrument comes standard with 7 angles and can be augmented with the BI-DNDC, our differential refractometer for use as either an RI concentration detector or to determine the differential refractive index increment. For small macromolecules, the new 90PDP Debye plot option is available with our Nanobrook Omni for molecular weight determination. This is an excellent option if you need to measure particle size and/or zeta potential as well as molecular weight.
Latest posts on Molecular Weight:
- Using Static Light Scattering to Measure Polymer Molecular Weights
- Role of Light Scattering in Production of Performance Polymers and Other Functional Materials
- Static Light Scattering of Biomacromolecules: MW of Protein Samples Measured with the BI-200SM
- Optimizing GPC performance: Multi-Angle Static Light Scattering detection using the BI-MwA
- Molecular Weight Determination of Carbonic Anhydrase with the BI-MwA
Find the right Molecular Weight testing instrument
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Uzito wa molekuli na ukubwa ni mali mbili muhimu za macromolecules zote ikiwa ni pamoja na polima muhimu ya kibiolojia na synthetic. Utendaji na processability ni moja kwa moja kuhusiana na vigezo hivi. Kwa nini uzito wa molekuli ni muhimu Uzito wa molekuli ni mali muhimu ya macromolecules zote. Mifano ya maeneo ya maombi ni utengenezaji wa biopharmaceuticals na dawa na utafiti wa polima. Katika viwanda vya utengenezaji wa dawa za kibiolojia, wanasayansi wa maendeleo wanahitaji kuweza kuunganisha ukubwa wa chembe na uzito wa molekuli ili kuamua MWCO sahihi (uwiano wa molekuli) kwa usindikaji wa ultrafiltration wa dawa za kibiolojia. Ikiwa MWC haijulikani, gharama ya makosa inaweza kuongeza hadi mamia ya maelfu ya dola kwa kila kundi lililopotea. Sekta nyingine muhimu inayotumia uzito wa molekuli ni sekta ya dawa. Kwa mfano, uzito wa molekuli ya dawa ya mwisho hufuatwa na QC ili kuhakikisha kuwa dawa ziko katika safu sahihi ya kipimo ili kuepuka kuwa na ufanisi au kuunda tukio la overdose katika matumizi. Katika viwanda hivi, uzito wa molekuli hupimwa katika R&D katika uzalishaji na pia wakati wa udhibiti wa ubora. Katika sayansi ya polima, uzito wa molekuli ya polima mpya synthesized ni mara nyingi kipimo na static mwanga kutawanyika. Wengi wa mali muhimu ya vifaa vipya ni kuhusiana na urefu wa mlolongo wa polima precursors, kama vile vipimo kimwili occupied na minyororo hiyo. Vipimo hivi ni muhimu kwa ajili ya uzalishaji wa vifaa vya utendaji. BIM-MWA inaweza kutumika kama chombo cha kujitegemea au inaweza kuunganishwa na chombo cha GPC. Chaguzi zinapatikana kwa ajili ya wote mtiririko au kundi hali. Kwa mfano, kipimo cha MVA kinaweza kuunganishwa na kipimo cha mviringo cha DNDK, ambacho kinaweza kutumika kama kipimo cha mviringo wa RI au kwa kuongeza kiwango cha mviringo. Kwa macromolecules ndogo, chaguo jipya la 90PDP Debye plot linapatikana na Omni yetu ya Nanobrook kwa ajili ya kuamua uzito wa molekuli. Hii ni chaguo bora kama unahitaji kupima ukubwa wa chembe na / au zeta uwezekano kama vile uzito wa molekuli. "Makampuni ya ""Molecular"" na ""Biomolecular"" pia huonyesha kuwa ""mchanganyiko wa molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli ya molekuli."