instruction: what number of patients were given neuromuscular blocking agent two or more times until 2103?
response: SELECT COUNT(DISTINCT t1.uniquepid) FROM (SELECT patient.uniquepid, COUNT(*) AS c1 FROM patient WHERE patient.patientunitstayid = (SELECT treatment.patientunitstayid FROM treatment WHERE treatment.treatmentname = 'neuromuscular blocking agent' AND STRFTIME('%y', treatment.treatmenttime) <= '2103') GROUP BY patient.uniquepid) AS t1 WHERE t1.c1 >= 2