Here's a short story:

By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion. (End of story)

Provide your best guess for the following question based on this story, and describe how likely it is that your guess is correct as one of the following expressions:

Almost Certain
Highly Likely
Very Good Chance
We Beleive
Probably
Probable
Likely
Better than Even
About Even
Probably Not
We Doubt
Unlikely
Little Chance
Chances Are Slight
Improbable
Highly Unlikely
Almost No Chance

Give ONLY the guess and your confidence, no other words or explanation. For example:

Guess: <most likely guess, as short as possible; not a complete sentence, just the guess!>
Confidence: <description of confidence, without any extra commentary whatsoever; just a short phrase!>

Here are a few examples of questions and answers:

Question: Who isolated epinephrine?
Guess: John Abel
Confidence: <appropriate level of confidence in this guess>

Question: Was it pure?
Guess: no
Confidence: <appropriate level of confidence in this guess>

Question: What form was it
Guess: in an impure state
Confidence: <appropriate level of confidence in this guess>

Question: Did someone produce it in a pure state?
Guess: yes
Confidence: <appropriate level of confidence in this guess>

Question: Who?
Guess: Jokichi Takamine
Confidence: <appropriate level of confidence in this guess>

Question: What was it used for?
Guess: for the acute treatment of asthma attacks
Confidence: <appropriate level of confidence in this guess>

Question: How was it used?
Guess: it was injected
Confidence: <appropriate level of confidence in this guess>

Question: Was there another way it was administered?
Guess: yes
Confidence: <appropriate level of confidence in this guess>

Question: How?
Guess: inhaled
Confidence: <appropriate level of confidence in this guess>

Question: What was the brand name?
Guess: Primatene Mis
Confidence: <appropriate level of confidence in this guess>

Question: When could someone buy it in the US?
Guess: until 2011
Confidence: <appropriate level of confidence in this guess>

Question: Who else offered the drug?
Guess: Parke Davis
Confidence: <appropriate level of confidence in this guess>

Question: What was it called?
Guess: Adrenalin
Confidence: <appropriate level of confidence in this guess>

Question: What else was epinephrine used to treat?
Guess: nasal congestion
Confidence: <appropriate level of confidence in this guess>

Question: Starting when?
Guess: 1929
Confidence: <appropriate level of confidence in this guess>

Question: What did people want to learn more about?
Guess: the mechanism of chemical signalling
Confidence: <appropriate level of confidence in this guess>

Question: Of what chemicals?
Guess: adrenal extracts
Confidence: <appropriate level of confidence in this guess>

Question: Why?
Guess: they had a profound effect on many different tissue types
Confidence: <appropriate level of confidence in this guess>

Question: What did they want to make?
Guess: new drugs
Confidence: <appropriate level of confidence in this guess>

Now answer the following question in the same format.

Question: What was an early usage of the chemicals?

blood pressure raising and vasoconstrictive effects