Sports industry is a sunrise industry in China. The development of Listed enterprises in the sports industry has gradually become an important symbol of the development and competitiveness of China's sports industry. This paper takes Li Ning Sports Goods Listed Company as the research object, describes the characteristics of management of sports listed companies, and systematically expounds the inevitability of management of sports listed companies, points out the main problems and put forward the improvement countermeasures, so as to provides suggestions for the continuous improvement of sports goods listed companies in China.


Taking the universities directly under the Ministry of Education as example,this article reports that geographic-spatial features of universities influence inter-university competitions;universities in the same city tend to form sharp competitions against each other.When making policies,neighboring universities tend to take each other as reference and prediction,thus forming strategy interaction.The geographic distribution of universities significantly influences inter-university competition behaviors.Negative correlation exists between geographic distance and competition level of the universities-the shorter the former,the higher the latter.Generally speaking,when the neighboring university raises the admission score by 1%,the target university will raise the score by 0.27%.


The lessons from the last economic recession tell us that governments spend a lot of money on capital expenditure, such as the construction of buildings, roads and bridges in order to restore the economy. However, even if governments try to invest their money in capital expenditure, it is questionable whether expenditures on capital structures are really effective in achieving an economic recovery. Thus, our study attempts to investigate whether capital expenditure has a positive impact on economic growth. To achieve this goal, this article includes the endogenous growth model. More specifically, the endogenous growth model can be divided into two models: a basic model and an extensive model, which also set political and institutional factors as control variables. By using a panelled data analysis of US states from 1990 to 2013, the empirical results of the endogenous growth model suggest that the proportion of capital expenditure as a percentage of GSP is negatively related to economic growth, while state government savings as a percentage of GSP has a positive relationship with it. Therefore, capital expenditure in the US states is not an effective tool for fiscal policy and their effectiveness should be further discussed.


The present invention provides a method for preparing ethanol through potato fermentation by using yeast. According to the present invention, yeast is adopted as a starting strain, potatoes are adopted as a fermentation raw material, liquefaction, saccharification and other treatments are performed to carry out fermentation to produce ethanol, and an ethanol yield is adopted as an indicator to research optimal parameters in the fermentation process.


The flora of Carrizo Arroyo is typical of a seasonally moisture-limited environment. Dominant elements were conifers, callipterids and the pteridosperm Sphenopteridium, all plants usually associated with indicators of seasonal moisture regimes. More generally, the Virgilian-Wolfcampian transition was a time of change from dominance of the tropical landscape by floras rich in tree ferns, pteridosperms, and lycopsids, to one dominated by conifers, peltasperms, and cycadophytes. The two types of floras do appear to have overlapped, but possibly in a manner reflective of local landscape heterogeneity. At Carrizo Arroyo for example, the wetland elements are rare and fragmentary, indicating local transport, most likely from wet microhabitats proximate to the site of deposition. Local environmental heterogeneity appears to have been part of larger scale heterogeneity in the region, probably reflective of climatic and edaphic differences in this tectonically active 105


The Dst index is produced using low-latitude ground magnetic field measurements and frequently is used as an estimate of the energy density of the ring current carried mainly by energetic (∼ 10 – 200 keV) ions relatively close to the Earth. However, other magnetospheric current systems can cause field perturbations at the Earth's surface: for example, dayside magnetopause currents are known to contribute to the Dst index. It has also been suggested that the nightside tail current sheet can significantly affect the Dst index during high magnetic activity periods when the currents are intense and flow relatively close to the Earth. In this study, several disturbed periods are input into Tsyganenko magnetic field models. From the time series of the external and internal fields an artificial Dst index is computed using the same procedure followed in the actual Dst calculation. A tail region in the magnetosphere is explicitly defined and the T96 and T89 models are used to calculate the effect of current within this tail region on ground measurements and therefore on Dst. The results are then compared with the measured Dst to determine the tail current contribution to Dst. It is found that for a geomagnetic storm and a storm-time substorm with Dst of ∼ 80 nT the tail current contribution is between 22 and 26 nT. The same analysis is also applied to several isolated non-storm-time substorms, yielding a nearly linear relationship between Dst and the tail current contribution. This contribution is approximately one quarter of Dst.


Abstract : This report contains a detailed description of a computer program that was developed for use with the Interdata 7/32 computer and the interfaced Nike Hercules radar systems located at the MTTR site at White Sands, New Mexico and the Poker Flat site in Alaska. The program can process in real-time a complete data reduction for an MRN rodketsonde or a list of 2 minute layer winds for a radiosonde. For a rocketsonde, the program utilizes the temperature telemetry data, the positional radar data, and the operator inputs of rocketsonde temperature calibration values and base level tie-in data from a radiosonde flight to produce an MRN(WDC-A) format listing of the following: 1 KM corrected and uncorrected winds; Significant level temperature data; 1 KM thermodynamic data; Significant level thermodynamic data; MRN 30 cards (image); Mandatory thermodynamic data; MRN 40 cards (image); and Printer plot of X and Y component winds and temperatures versus 1 KM altitudes. For a radiosonde, the program utilizes the positional radar data to produce a listing of two-minute layer winds at 1 minute intervals.


Across the Anglo-American world, a pervasive sense of wariness and concern about strangers continues to haunt influential discourses and practices that regulate and shape youth citizenship. In particular, (1) media-centred accounts of 'stranger danger', (2) dominant citizenship discourses taught in schools and (3) government policies regulating young people's civic lives, remain significant in shaping how strangers are made meaningful for youth. Through these discourses and practices, the stranger increasingly comes to be a fetish figure, a body and symbolic form whose very figurability is rendered a problem in the first instance. These developments are problematic, in large part because strangers are a necessary and enabling feature of modern democracies. Accordingly, in this paper, I examine the three aforementioned fields of discourse and practice as they have operated broadly over the past decade in Canada, Britain and the United States. I show how strangers are made difficult and dangerous others for youth and make clear how these constructions regulate and threaten a vibrant public world. I conclude by hinting at how stranger hospitality might be taken up differently in schools (and other public fora) as part of nurturing our collective democratic futures.


OBJECTIVES
This article examines the association of family history of heart disease and leisure-time physical activity with incident heart disease.

DATA SOURCE
The data are from the 1994/95, 1996/97 and 1998/99 longitudinal household components of Statistics Canada's National Population Health Survey. This study is based on information provided by 9,255 respondents aged 20 or older who reported that, in 1994/95, they were free of diagnosed heart disease and in good health.

ANALYTICAL TECHNIQUES
Multiple logistic regression was used to estimate the association of family history and physical activity with a new diagnosis of heart disease, while controlling for age, sex, educational attainment, smoking, high blood pressure, diabetes, and body mass index.

MAIN RESULTS
When family history and other risk factors were taken into account, people who, in 1994/95, engaged in regular physical activity at a moderate level or beyond had lower odds of receiving a new diagnosis of heart disease than did sedentary individuals. People with a family history of heart disease who regularly participated in at least moderate physical activity had lower odds of developing heart disease than did their sedentary counterparts.


The displaced phased center antenna (DPCA) method of clutter cancellation for ground moving target detection from airborne platforms has been in use for a number of decades. Application of the DPCA method for spaceborne Doppler weather radar velocity estimation was suggested in 2007. The initial description and analysis of the technique was followed several years ago by demonstration using a multiantenna airborne radar. Recent reviews of methods and technology for spaceborne cloud and precipitation radar have also mentioned possible use of DPCA. However, to date, analyses of the application of DPCA to spaceborne Doppler weather radar have assumed that the two channels and antennas are identical, including perfect alignment, and that the DPCA condition is well-satisfied. This study uses simulation to examine the effects of relaxing these assumptions. The simulation method and its validation are discussed, with companion analytical calculations in the appendix. Next, simulations are used to show the effects on the Doppler estimates from errors in pointing and positioning relative to the ideal DPCA. The DPCA technique is relatively robust to possible errors, indicating that a practical DPCA radar system can provide precise Doppler measurements from space.

Analytical and simulation results show that the displaced phase center antenna approach can enable spaceborne atmospheric Doppler radar measurements with good accuracy, even in the presence of antenna mispointing and other system errors.


Objective To investigate the relationship between chromosome abnormalities and Y chromosome microdeletion of azoospermia factor(AZF) in patients with azoospermia and oligozoospermia.Methods Both routine periphearl blood lymphocytes cytogenetic analysis and detection of AZF region microdeletion of Y chromosome by multiplex PCR were carried out in 136 infertile men,including 98 patients with azoospermia,24 patients with oligozoospermia and 14 patients with sever oligozoospemia.Results Chromosomal abnormalities were found in 34(25%) cases including 27 azoospermia,3 oligozoospermia and 4 severe oligozoospermia.Microdeletions in AZF region were found in 9(6.6%) cases.The incidence of AZF microdeletion was 5.1% and 1.5% in patients with azoospermia and severe oligozoospermia respectively.Conclusion The findings indicated that chromosomal abnormality and AZF microdeletion might be important genetic causes for male infertility.AZF microdeletion might be associated with Y chromosome abnormalities.


In this paper, we implement queuing techniques to a SIS Epidemic model. The aim of this paper is to study the epidemic model in a clear and effective manner. We extend the simple compartmental model into a the form of a retrial queue such that the model is elaborate. We intend to find a balance in the model such that the infection does not spread. We find the stationary distribution of the state variables. We derive the explicit formulae and recursive formulae for the joint stationary distribution of the number of repeated attempts and the state of the infective. We analyse the stochastic decomposition property. We also obtain a stability condition for the model. AMS Subject Classification: 39A10, 60K25, 60J20.


Art is a part of the cultural landscape. When it appears as a "ill-structured" discipline full of complexity, uncertainty and fragmentation, it is urgent to have a cognitive ability that is flexible enough to cope with various situations to help learners complete the task of constructing reality. Arthur Efland, an American art educator, puts forward many theories about the cognitive characteristics of art education, among which the theory of "cognitive flexibility" and cognitive lattice structure are regarded as the cognitive thinking characteristics worthy of attention.


A plastic welding device comprises first and second tools arranged respectively at a first support and a second support. The first tool is further movable by a first drive with respect to the first support in a first direction linearly between a first position and a second position. The movement along the first direction is defined by a first imaginary spherical coordinate system, the origin of which is arranged in the first position of the first tool. The z-axis as a first z-axis extends in the direction of the second support. For a first inclination angle between the first z-axis which is positive in the direction of the second support and the first direction it applies 0<=[upsilon]1<=pi/2, whereby a first component in the first tool can be brought into engagement with a second component in the second tool.


The primary goals of stroke rehabilitation are to encourage and foster functional improvement and neurological recovery. Organised stroke care, processes of care, early timing of rehabilitation and high intensity of rehabilitation therapies are important factors which have been identified as promoting better overall outcomes for individuals with stroke. This chapter examines the evidence for those elements which have been proven to be important in the effectiveness of stroke rehabilitation. Norine Foley, MSc Norhayati Hussein MBBS, Marcus Saikaley, BSc Jerome Iruthayarajah, MSc Joshua Wiener, PhD Candidate Mark Speechley, PhD Robert Teasell, MD


The effects of temperature on oxygen consumption rate and ammonia excretion rate of the constricted tagelus (Sinonovacula constricta) were studied in laboratory. The results showed that under the controlled conditions of ambient temperature 15~30 ℃, the relationship between oxygen consumption rate (O) [mg/h] and dry weight of soft tissue W(g) can be represented by the allometric equation O = aW~b, The relationship between ammonia excretion rate (N)[μg/h] and dry weight of soft tissue W(g) can also be represented by the allometric equation N = cW~d. It is indicated that the oxygen consumption rate (O_s)[mg/g·h] and ammonia excretion rate (N_a)[μg/g·h] are correlated positively with the water temperature and the high temperature can reduce the level of protein metabolism at the temperature range 15~30 ℃. The linear regression relationships among oxygen consumption rate (O) and temperature and dry weight of soft-tissue can be described by O = -0.3703 + 0.3204W + 0.0298T, and ammonia excretion rate (N) can be done by N = -154.0677 + 69.7488W + 7.9332T, the multiple relation coeffreient were 0.9773 and 0.9228 respectively.


At the mesoscopic level,the concrete is considered as a kind of three-phase non-homogeneous composite materials composed of coarse aggregate,cement mortar and bonded interface between them.In the two-dimensional case,based on the technique of free-form deformation for parametric curves,the outline of every aggregate and interface is expressed by a defined and unified parametric equation,and then the concrete random parameterized aggregate model is established.When the concrete aggregate is gravel or crushed stone,the model gives a concrete random numerical structures with the controllable grade,content and rate of composite,and shows an advantage in describing two-dimensional three-phase composite materials composed of the aggregate,mortar and bonding interface.At last,the finite element mesh model and numerical load test by axial compression and tension are given by MATLAB,AutoCAD and ANSYS.The results show that the method can satisfy the requirements of numerical analysis of the static and dynamic mechanical properties of concrete.


This paper presents a microcontroller implementation of a fuzzy logic control algorithm applied to the mobile robot Pioneer3-DX. The design and implementation of the fuzzy controller is described. Both speed and steering control are achieved using the same real-time fuzzy controller. The description starts with an example for a circular path following, then presents an implementation of the algorithms for following a generalized curve path.


Parasites are highly prevalent in livestock worldwide and infect over one fourth of the human population also. Parasites are successful in evading host immune responses, and vaccination can prove to be an effective way to control them. However, currently very few vaccines are available against parasitic infection.


The leadership team of Monsanto's Integrated Financial Services (IFS) unit realized in 1997 that it needed to make changes in order to manage effectively in a time of transition for its parent organization. Consequently, it set out to develop a clear vision and to support the vision with metrics. The unit's story is a lesson in the development and business value of a Measurement‐Managed OrganizationTM (MMO). MMOs distinguish themselves by achieving sustained profitability and agility at lower levels of risk. The authors describe the process used by the Monsanto finance team and the importance of identifying key metrics early in the change initiative.


Abstract Free-stream turbulence (FST) induced boundary layer transition is an intricate physical process that starts already at the leading edge (LE) with the LE receptivity process dictating how the broad spectrum of FST scales is received by the boundary layer. The importance of the FST integral length scale, apart from the turbulence intensity, has recently been recognized in transition prediction but a systematic variational study of the LE pressure gradient has still not been undertaken. Here, the LE pressure gradient is systematically varied in order to quantify its effect on the transition location. To this purpose, we present a measurement technique for accurate determination of flat-plate boundary layer transition location. The technique is based on electret condenser microphones which are distributed in the streamwise direction with high spatial resolution. All time signals are acquired simultaneously and post-processed giving the full intermittency distribution of the flow over the plate in a few minutes. The technique is validated against a similar procedure using hot-wire anemometry measurements. Our data clearly shows that the LE pressure gradient plays a decisive role in the receptivity process for small integral length scales, at moderate turbulence intensities, leading to variations in the transitional Reynolds number close to 40 %. To our knowledge, this high sensitivity of LE pressure gradient to transition has so far not been reported and our experiments were therefore partly repeated using another LE to ensure set-up independence and result repeatability.


Abstract This research note records the most recent Chinese figures for the population of Tibet, together with the official explanation for a decline in 1959, compared with the totals announced for 1953 and 1957, followed by a steady increase since 1960. Brief reference is made to political and economic changes which are affecting the composition of population.


To account for the massive uncoordinated random access scenario, which is relevant for the Internet of Things, Polyanskiy et al. (2017) proposed a novel formulation of the multiple-access problem, commonly referred to as unsourced multiple access, where all users employ a common codebook and the receiver decodes up to a permutation of the messages. In this paper, we extend this seminal work to the case where the number of active users is random and unknown a priori. We define a random-access code accounting for both misdetection (MD) and false alarm (FA), and derive a random-coding achievability bound for the Gaussian multiple access channel. Our bound captures the fundamental trade-off between MD and FA probabilities. It suggests that the lack of knowledge of the number of active users entails a small penalty in energy efficiency when the target MD and FA probabilities are high. However, as the target MD and FA probabilities decrease, the energy efficiency penalty becomes more significant. For example, in a typical IoT scenario with framelength 19200 complex channel uses and 25–300 active users in average, the required energy per bit to achieve both MD and FA probabilities below $10^{-1}$ , predicted by our bound, is only 0.5–0.7 dB higher than that predicted by the bound in Polyanskiy et al. (2017) for a known number of active users. This gap increases to 3–4 dB when the target MD probability and/or FA probability is below $10^{-3}$ . Taking both MD and FA into account, we use our bound to benchmark the energy efficiency of slotted-ALOHA with multi-packet reception, of a decoder that simply treats interference as noise, and of some recently proposed unsourced multiple access schemes. Numerical results suggest that, when the target MD and FA probabilities are high, it is effective to estimate the number of active users, then treat this estimate as the true value, and use a coding scheme that performs well for the case of known number of active users. However, this approach becomes energy inefficient when the requirements on MD and FA probabilities are stringent.


The rate of anionic polymerization of pivalolactone with polystyrene dicarboxylates decreased with conversion, suggesting deactivation of the propagating chain end by precipitation of the polymer during polymerization. The presence of unreacted initiator was explained by slow initiation for formation of a living polymer of pivalolactone. Various factors affecting block efficiency were discussed, and high efficiency was obtained for the preparation of block copolymers containing a long pivalolactone segment by using more nucleophilic polystyrene dicarboxylates. Block copolymer of acrylonitrile and pivalolactone was prepared from polyacrylonitrile dicarboxylates.


Tekmos has developed a 250°C ASIC technology that uses the X-Fab XI10 SOI process. A gate array architecture was chosen to allow reduced mask costs and quicker manufacturing cycle times. The design of the technology includes first determining the optimum routing grid and then designing of the basic gate array transistors. The "A" style transistor was chosen over the "H" style to create stronger transistors. The choice of the transistor in turn sets the characteristics of the basic "Block" that is used in the gate array architecture. Another factor in the block design is the requirement for a pre-determined source with "A" transistors. This prevents the use of shared diffusions that are used in most gate array architectures and resulted in a different block layout. The pre-determined sources also required a change to the logic cell library. Since the basic transmission gate found in most flop designs cannot be used, alternative logic architectures were developed. By implementing the SOI specific library in...


Background : Body and mind work perfectly after yoga. To find out the effect of yoga (pranayama) on respiratory parameter a cross sectional study was conducted. Methods: Subjects selected are people (male and female) aged from 50-70 year without any active medical complain. Study is conducted in RMCH Bareilly U.P. Results: Respiratory parameters measured are FVC, FEV1, ratio of FVC/FEV1 and PEFR. These parameters are taken before and after 12 week of pranayama. Conclusion: 12 weeks of regular yogic training in elderly individuals showed definite improvement in their ventilatory functions, as observed from improvement in their FVC, FEV1 FEV1/FVC RATIO and PEFR.


Bengkalis Regency, Riau Province is one of the areas prone to fires, especially peat areas since 2014 until now. One of the area in Bengkalis Regency which also the center of peatland fires is Bukit Batu District. To tackle the occurrence of peatland fires in the Bukit Batu District, a number of stakeholders have collaborated and are actively involved in the process of overcoming peatland fires starting from prevention, mitigation, preparedness, emergency response and recovery. This study was conducted using qualitative approach by collecting data through field observations and interviews with in actors of peatland fires management in Bukit Batu District consisting of the Government, Corporations, Academics, Mass Media, and Community Groups. The result shows that stakeholder involvement have a role in increasing awareness of peatland fires and stakeholders are actively involved in risk communication through the use of communication media such as dialogue, counseling and coordination between stakeholders both face-to-face and online by using Whatsapp as media communication. The stakeholders engagement also plays a role in mobilizing the community to activate community self-reliance in extinguishing land fires and creating added value in community empowerment activities so as to prevent land fires.


Subsurface vertical barriers have been used as components of containment systems to prevent or reduce the impact of contaminant sources on ground-water resources. A better understanding of the hydraulic head distribution associated with vertical barriers can enhance the ability of existing performance monitoring systems to detect breaches in physical containment systems and may aid in the design of new performance monitoring systems. Given the current regulatory interest in containment systems as either supplemental or stand-alone remedial alternatives and the lack of adequate performance monitoring strategies at most existing hazardous waste sites utilizing vertical barrier technologies, there is an immediate need for general guidelines for determining whether a containment system is functioning as intended. This technical note describes an approach for evaluating the performance of containment systems, based on relative spatial and temporal hydraulic head distributions.


In this essay I attempt to draw some crucial theoretical parallelisms between ancient Greek cosmology and the Anthropocene. Taking inspiration from Marcel Detienne and Timothy Morton's work, I deploy the figure of Dionysos as a conceptual persona which can help us think of strangeness as a non-human mode of relationality Anthropocene societies must urgently engage with. Events such as the ongoing Covid-19 epidemic, through which non-humans are brought to the forefront of politics and social relations, traditionally result to attempts of sublating strangeness through human modes of knowledge. As I argue, epidemics instead demand the creation of practices, collectives and techniques through which strangeness is not eliminated or 'understood', but rather elevated to a fundamental feature of social relations. In such sense, the ancient world presents a critical vector of intervention to the current state of the Anthropocene, since it showcases a cosmos in which human life and society is constantly embedded and negotiated amid non-human strangeness.


Activation of G protein-coupled vasopressin V2 receptor (V2R) is critical in water and electrolyte transport in the kidney collecting duct (CD) cells. Stimulation of V2R affects several downstream pathways, including PKA, PI3K/AKT, Wnt, and Ca2+/calmodulin. Previous studies have shown that MAP kinases are also involved as an apparent downstream signaling pathway of V2R. However, the role of MAP kinases and their substrate proteins in the vasopressin signaling, including the regulation of AQP2 expression and phosphorylation, are unclear. In the present study, substrates of MAP kinases were identified using bioinformatic analyses, and they were mapped on the downstream signaling pathways of V2R. Tripartite motif-containing protein 28 (TRIM28) was identified as a substrate of ERK1 as well as a vasopressin-responsive protein via bioinformatic tools. We further evaluated whether TRIM28 plays a role in vasopressin-mediated regulation of AQP2 in the kidney CD.

 To identify comprehensive substrates of MAP kinases in the kidney CD, we investigated 1) the expression of MAP kinases in CD cells by use of databases based on high-throughput profiles of transcriptome and proteome (http://hpcwebapps.cit.nih.gov/ESBL/Database/index.html); and 2) MAP kinases substrates expressed in the CD cells by use of protein phosphorylation databases (PhosphoNetworks and RegPhos 2.0). The identified substrates were mapped on the downstream signaling of V2R. Cellular and subcellular localization of selected substrate protein (TRIM28) was examined by immunohistochemistry. The role of TRIM28 in vasopressin-mediated AQP2 regulation was examined by quantitative real-time PCR (qRT-PCR) and semiquantitative immunoblotting after RNA interference of TRIM28 in mpkCCDc11 cells.

 Immunoblotting of mpkCCDc11 cells revealed that both p-ERK1/2 and pS261-AQP2 expression was decreased in response to dDAVP (10-9 M) stimulation. In silico analyses demonstrated that five MAP kinases (ERK1, ERK2, ERK3, JNK2, and MAPK p38 alpha) were identified as the MAP kinases expressed in kidney CD cells. Based on several protein kinase-substrates databases, 189 proteins were identified as the substrates of the five MAP kinases. In particular, sequential data mining revealed TRIM28, as the substrate of ERK1, has the only one phosphorylation site which was down-regulated by vasopressin stimulation. Since TRIM28 is a transcription cofactor and also a ubiquitin-protein E3 ligase, we examined whether TRIM28 is involved in the regulation of AQP2 expression as a mediator of MAP kinases action. Immunofluorescence labeling of mouse and rat kidneys revealed that TRIM28 was exclusively expressed in the nuclei of the tubular epithelial cells, including CD cells. dDAVP-induced AQP2 mRNA and protein up-regulation was significantly attenuated in mpkCCDc11 cells with siRNA-mediated knockdown of TRIM28.

 We identify MAP kinase substrates in the kidney CD, which are mapped on the downstream signaling pathways of V2R. TRIM28 is identified as a substrate of MAP kinases that involves in vasopressin signaling pathways. TRIM28 is likely to play a role in the regulation of AQP2 expression, particularly in the AQP2 transcription.


We describe a method to process the seismic data generated by a plurality of sources and registered by an appropriate distribution of receivers, which provides new seismic signals as if in the position of the receivers (or sources) there was an ideal reflector, even if this reflector is not present there. The data provided by this method represent the signals of a virtual reflector. The proposed algorithm performs the convolution and the subsequent sum of the real traces without needing subsurface model information. The approach can be used in combination with seismic interferometry to separate wavefields and process the reflection events. The application is described with synthetic examples, including stationary phase analysis and with real data in which the virtual reflector signal can be appreciated.


A new species of Apobaetis is described based on nymphs and male imago, and the male imago of A. fiuzai. Specimens were collected in the state of Amazonas, northern region of Brazil. Apobaetis hamadae sp. n. can be easily distinguished from the other congeners by the following combination of characteristics: male imago: (1) abdominal colour pattern; (2) area between forceps not excavated medially. Nymphs: (1) distal margin of labrum with shallow medial emargination and with four to five spatulated setae near midline; (2) maxillary palp 1.4× longer than galea-lacinia; (3) tarsal claws 1.2× times longer than tarsus. The male imago of A. fiuzai can be easily distinguished by the following characteristics: (1) abdominal colour pattern; (2) area between segments I of forceps with a deep V emargination.


Swain CB, Kirby TE, Altschuld JW. Simulated Altitude via ReBreathing Improves Performance in Well-Trained Cyclists. JEPonline 2010; 13(6):21-34. Commercially available re-breathing devices are now being used by athletes to instigate short bouts of extreme hypoxia in an effort to improve athletic performance. Scientific evidence to support this practice is lacking. Purpose: To perform a randomized controlled trial to examine the effect of this methodology on aerobic and anaerobic type work. Methods: Over 15 days, 18 well-trained male cyclists used a re-breathing device to instigate hypoxia (6 min) alternated with room air (4 min) and repeated for approximately 1 hr/day. Subjects were assigned to a constant exposure sham group, equivalent to 150 m (CON) or progressively increased hypoxic group equivalent to 3600-6300 m (TRT). The critical power protocol was used to examine power output in time trial efforts (TT's). Performance was also investigated through measurements of blood lactate concentration, oxygen consumption (VO2), and heart rate (HR). Blood characteristics were additionally measured. Results: There was a significant improvement for the TRT group in the 15 min TT (p=.004) and estimated 60 min TT (p=.024) compared to no improvement in the CON group. The TRT group improvement was 3-4.5% in average power output. There were no significant differences in the 3 min TT for either group. Nor were there significant differences in hematological measures for either group. A decreased VO2 (p=.075) and HR (p=.026) was revealed for the TRT group. Conclusion: In competitive cyclists, intermittent hypoxic training using a re-breathing device resulted in improved performance for events which rely on aerobic power but none for anaerobic power. It is suggested that re-breathing intermittent hypoxic training may be utilized Chronic exercise and metabolism in SHR 22 as an alternative to terrestrial or other forms of simulated altitude, in efforts to mediate performance gains in endurance type events.


Hospitals frequently evaluate their service quality based on the care and services provided to patients by their clinical and non‐clinical staff.1,2 However, such evaluations do not take into consideration the many interactions that patients have in online patient communities with the health‐care organization (HCO) as well as with peer patients. Patients' interactions in these online communities could impact their perceptions regarding the HCO's service quality.


Summary
Reliability centered maintenance (RCM) is a cost-effective way to maintaining complex systems, transmission network being one. This paper presents a new method for nonperiodic maintenance scheduling of transmission's elements focusing on failure mode analysis. Adopting a nonperiodic mode-based viewpoint to maintenance, this paper introduces 6 plans for maintenance in each failure mode. The related Markov model for each plan is proposed, too. Given these Markov models, attempts are made to determine the best strategy of maintenance and the optimum rate of inspection and maintenance for each mode. Furthermore, to increase the practicality of the presented method and to reduce the overall maintenance cost, we coordinated the maintenance plans of the failure modes of an element, together. Finally, applicability of the presented method is demonstrated using an illustrative example.


Taking Guangxi as a sample,the author analyzes the national difference on social capital's effect in occupation changes through the comparative research on different nationatities of Guangxi,and explains the reason for the differences on social capital's effect in occupation changes by using sociological and ethnology theories.


Background Persistent genital arousal disorder (PGAD) is a condition seen mainly in women characterised by spontaneous and often unrelenting sensation of genital arousal in the absence of sexual desire or stimulation. These sensations typically do not fully remit with orgasm and are by definition intrusive and distressing. The condition overlaps in some cases with pudendal neuralgia but needs to be differentiated from hypersexuality. Patients may present preferentially to GUM clinics in the knowledge that sexual symptoms will not be trivialised. Different opinions exist as to triggers, causes and treatment. Taking this into consideration we analysed a cohort of patients with PGAD assessing whether they were any common themes in terms of precipitating and relieving factors. Aim To describe our clinical experience and ascertain number of patients with diagnosis, common themes and treatment modalities. Methods 57 patients were diagnosed with PGAD since departmental code was introduced in 2006 and 39 patients notes were located and reviewed. Results Of these 69% were in a relationship and 64% had no history of past sexual abuse. Relieving factors were also varied among the cohort including masturbation and distraction. 95% were referred for mindfulness cognitive behavioural therapy and 51% were on medication such as amitriptyline, gabapentin, venlafaxine and nortriptyline. 72% were referred for pelvic floor physiotherapy. Discussion PGAD is rarely seen estimates say 1–6% are affected by this hence it is important as sexual health clinicians to be aware of it to reduce delays in diagnosis. Overall management of PGAD requires a holistic approach with multidisciplinary team involvement.


The structure"N_1的N_2"that has not obvious modifying relation inside should still be placed in the category of the nominal modification-center structure for the reasons:(1) The criterion for classifying the syntactical structures is their surface syntactical characteristics and the characteristics of "N_1的N_2"are quite similar to those of the nominal modification-center structure,(2) A category includes both prototypal category and non-prototypal category.So it is natural that the structure"N_1的N_2"which bears much family similarity to the prototypal nominal modification-center structure is placed to the nominal modification-center structure as a non-prototypal category,and (3) This classification can also be proved formally:the non-prototypal nominal modification-center structure has the same syntactical variation as the prototypal one.


The occurrence of the Mathieu-type instability was investigated theoretically and experimentally. The main aim of this paper is utilization of auto-parametrically excited oscillation to increase efficiency of wave energy converters. In this paper, the subject is the auto-parametrically excited oscillation of a spar-buoy type point absorber with the coupled motions of pitch and heave. A spar-buoy model with innovative ballast control system was made and the model experiments were carried out to realize the large oscillating motion based on the Mathieu-type instability. The ballast control system installed in the buoy model can make the ballast move in the vertical direction to realize a certain change of the pitch natural period. Free-decay experiments were performed to determine the natural frequencies and damping ratios with different ballast positions. During the experiments in regular waves, it was observed that the pitch motion became unstable and the large pitch occurred suddenly. Based on time histories of experimental results, the points (peaks and troughs) are extracted near the large pitch occurring and t he periods of transient states were calculated to derive the parametrical values of stability. Considering these values with plotted stability chart of Mathieu equation, the occurrence of the large pitch motion is discussed.


In this time, ECU using in a car is increasing. Performance is too. ECU like using Navigation, GPS and Camera for vehicle is expended market share in a vehicle market. As a result, vehicle is no longer a stand-alone product. We should think about using new signal for robustness to each ECU. The increasing of ECU makes opportunities to improve robustness each ECU fail safe. This Study is talk about ESP's fail safe and shows that how we take and make a chance and provide our customer improve their driving environment.


The distinct characteristics of short pulse laser interactions with a metal target under conditions of spatial confinement by a solid transparent overlayer are investigated in a series of atomistic simulations. The simulations are performed with a computational model combining classical molecular dynamics (MD) technique with a continuum description of the laser excitation, electron-phonon equilibration, and electronic heat transfer based on two-temperature model (TTM). Two methods for incorporation of the description of a transparent overlayer into the TTM-MD model are designed and parameterized for Ag-silica system. The material response to the laser energy deposition is studied for a range of laser fluences that, in the absence of the transparent overlayer, covers the regimes of melting and resolidification, photomechanical spallation, and phase explosion of the overheated surface region. In contrast to the irradiation in vacuum, the spatial confinement by the overlayer facilitates generation of sustain...


The creation of spin-off firms from universities are seen as an important mechanism for the commercialization of research, and hence the overall contribution from universities to technology develop...


Effects of anisotropy on the geodesic acoustic mode (GAM) are analyzed by using gyro-kinetic equations applicable to low-frequency microinstabilities in a toroidally rotating tokamak plasma. Dispersion relation in the presence of arbitrary Mach number M, anisotropy strength σ, and the temperature ration τ is analytically derived. It is shown that when σ is less than 3 + 2τ, the increased electron temperature with fixed ion parallel temperature increases the normalized GAM frequency. When σ is larger than 3 + 2τ, the increasing of electron temperature decreases the GAM frequency. The anisotropy σ always tends to enlarge the GAM frequency. The Landau damping rate is dramatically decreased by the increasing τ or σ.


The mechanical properties of a nanomechanical resonator have a significant impact on the performance of a resonant Nano-electromechanical system (NEMS) device. Here we study the mechanical properties of suspended membranes fabricated out of low-pressure chemical vapour deposited silicon nitride thin films. Doubly-clamped membranes of silicon nitride with thickness less than 50 nm and length varying from 5 um to 60 um were fabricated. The elastic modulus and stress of the suspended membranes were measured using Atomic Force Microscope (AFM) based nanomechanical spectroscopy. The elastic modulus of the suspended membranes was found to be significantly higher than that of corresponding thin films on the substrate. A reduction in the net stress after the fabrication of membrane was observed and is explained by estimating the contributions of thermal stress and intrinsic stress. We establish a mathematical model to calculate the normalized elastic modulus of a membrane. Furthermore, we observe that the stress in a membrane changes with its length. We also develop an experimental model for the SiNx membrane-Si substrate capillary force-gradient that could collapse the membrane.


A new numerical approach to model the strain-softening behavior is introduced at first,then aiming at Mohr-Coulomb criterion,evolution of different strength parameters and the corresponding stress-strain curves are studied by means of numerical analysis.Numerical results show that the post-peak part of the stress-strain curve is much influenced by the evolution process of strength parameters;and the confining pressure affects greatly the shape of post-peak curve.Thereby the post-peak part of the stress-strain curve obtained from laboratory and in-situ tests contains data of the evolution law of strength parameters.The presented study may provide a heuristic method to determine the law of post-peak evolution of strength parameters.


An extended UNIFAC group contribution model for the prediction of activity coefficients in associating mixtures was presented recently (Mengarelli et al., 1999). In the present work the model is applied to solutions containing alcohols, water carboxylic acids and inert components. The residual UNIFAC local composition term is re-parameterized in order to take into account only dispersive forces between associating and inert functional groups. Good representation of vapor-liquid and liquid-liquid equilibrium, as well as infinite dilution activity coefficients is achieved by using a single set of group interaction parameters.


The utility model discloses a control device of a carbon dioxide generator, which comprises a carbon dioxide sensor, a photosensitive sensor and a controller, wherein the carbon dioxide sensor is electrically connected with the controller to transmit the detected carbon dioxide concentration to the controller, the photosensitive sensor is electrically connected with the controller to transmit the detected light signal to the controller, and the controller controls the operation of the carbon dioxide generator. By adopting the control device of carbon dioxide generator provided by the utility model, the generator can supply carbon dioxide at any time according to the requirements of plant on carbon dioxide to meet the photosynthesis requirement of plant to the maximum degree, thereby solving the problem of income re-increase of big-arch shelter planting in countryside, increasing the peasant income, improving the countryside environment, and reasonably utilizing the resources.


Objective To evaluate the use of hypoglycemic drugs in certain hospital of Huai'an city in order to provide an reference for rational use of drugs in clinic.Methods Defined daily dose(DDDs),sales volume,and daily expenses of drugs in this hospital from 2006 to 2008 were analyzed with the method of DDD analysis.Results The total sales volumes of hypoglycemic drugs increased year by year,in which those of acarbose were the top of all in three years.The top 4 hypoglycemic drugs in respect of DDDs were dimethyl biguanide,extended action tablet of dimethyl biguanide,glimepiride and glipizide.Conclusions Dimethyl biguanide,extended action tablet of dimethyl biguanide,glimepiride and glipizide are the main oral hypoglycemic drugs and the structure of drug-use in this hospital is reasonable.Sales volumes of acarbose has not grown in pace with DDDs and its daily dissipation expense(DDE) is the highest among of them.Clinical doctors and patients have a preference for gene-recombined human insulin,increasingly taking place of animal-refined insulin.


Under many circumstances, seismic isolation is an effective way of reducing the impact of earthquakes on structures. Dynamic forces in the structure itself are reduced at the expense of relatively large displacements in the isolators. These displacements can generally be predicted adequately by simple methods and accommodated without difficulty. However, some circumstances appear to exist where the isolator displacements might be significantly larger than conventional analysis would suggest, or where simplified methods of analysis may prove inadequate and fail to predict the response properly. The paper explores the limits of the applicability of equivalent linear analyses and the response to ground motions which might lead to large displacements isolation that can be achieved.


Microelectromechanical sensors are essential components in all walks of life. However, bringing biospecific elements into miniaturised sensors has been a challenge, obstructing the development of bioanalytical applications. A new European project coordinated by VTT Technical Research Centre of Finland aims to change this.


ABSTRACT After the global crisis, European governments have stressed the importance of financing new ventures. Nevertheless, the existing literature provides little information on the extent to which financial development drives new businesses. Using panel data on 22 European economies between 2009 and 2017, this study fills this gap by providing evidence of a U-shaped relationship between financial deepening and nascent entrepreneurship. This implies that without a high level of financial deepening, the banking sector only favors established businesses at the expense of nascent entrepreneurship. The study also shows that banking intermediation and venture capital do not really encourage new businesses at the macro level, whereas financial stability does.


Large current transformers are mainly used in large scale generators. Its stability and reliability will influence the securit y of the whole electric power system, so the research to the stability of large current transformers is important. The paper analyzes the current of shielding w indings and its optimal design for three-phase 15000/5A current transformers ba sed on ANSYS. The simulation results demonstrate that the two methods of paralle l connecting 4 shielding windings and reversed polarity series connecting two pa irs of shielding windings are better.


In this article, we introduce a formal denition for integral arithmagons. Informally, an integral arithmagon is a polygonal gure with integer labeled vertices and edges in which, under a binary operation, adjacent vertices equal the included edge. By considering the group of automorphisms for the associated graph, we count the number of integral arithmagons whose exterior sum or product equals a xed number.


The absorption of soil cadmium and the purification efficiency by Dendronthena morifolium Tzvel,Sabina procumbens and Rosa chinensis Jacq and so on were studied with pot culture experiment.The result of the experiment is that there is no significant effect on the growth of these plant in a short time under the concentration 30 mg/kg(wind dry soil).After 50 days' absorption the Cd contents in soil has decreased about 0.3542~6.3784 mg/L.While the Cd contents in plants has increased about 1.7718 to 87.8807 mg/L.The results show that Rosa chinensis Jacq and Cardenia Jasminoides Euis have higher absorption capacities for Cd than the others and they can be used as renovating plants of Cd soil.


Blanching is an important step during the process of cooked shrimp.In order to control the blanching process and shrimp quality,a neural network model was established and the process parameters of blanching shrimp was optimized.The results showed that both blanching temperature and time had significant effect on bacteria inactivation,sensory index and hardness,while salt concentration had a less effect on these indexes.The optimal blanching process parameters were 2% salt concentration,(93±1)℃ blanching temperature,120s blanching time.Under these conditions,the blanched shelled fresh shrimps not only met the sanitary standards of aquatic cooked products but also had a better edible quality.


While psychology recognizes the importance of play in childhood, play also can be beneficial in other areas. It plays a role in learning and development, and plays a critical role in discovering the self and others. It is a medium for universal communication beyond the barriers of language, culture, and generations. In psychiatric consultations with children, more and more clinicians are using play with the youngest of children. This not only entails offering games, but also building a specific environment where the adult and child can meet and which is conducive to improving parenting skills. This paper is broken down into three sections. The first discusses some general considerations on the definitions and meanings of play. The second illustrates, through excerpts from parent-child therapies, how the clinician establishes an alliance through play. The third section discusses the links that are developed between parenting and qualities that are put into play between the actors involved. Most likely, play is a tool that can prevent later psychic disorders.


Measurements have been taken on a glass trennschaukel of eight tubes for the Ar-He system as a function of composition and with its hot and cold bulbs at 100°c and 0°c. For each mixture, several speeds for the mechanical push-pull motion of the gas which cover a wide enough range were tried. The results have been interpreted to determine the thermal diffusion factor α T, in conventional fashion as well as on the basis of a theory characterizing the low speed operation, developed here. Four such different possibilities of α t evaluation are discussed and values compared with the traditional ones obtained from the convection-free two-bulb apparatus. Lastly we discuss also in brief the prospect of estimating the diffusion coefficient as an important byproduct from measurements on trennschaukel runs.


This paper models leading firms in innovation markets deciding first whether to share knowledge, and then playing a market entry game. When firms are sufficiently patient, we show that the feasibility of intellectual property disclosure through licensing to outsiders provides a useful additional threat to entry by the punishing firm in the entry game. The opposite is true when firms are impatient; the availability of intellectual property disclosure makes coordination harder. We also show that if the probability that the leading firms will be able to innovate even without knowledge sharing is sufficiently high and firms are sufficiently patient, then it is also possible for the firms to enforce a knowledge-sharing agreement before innovation has taken place.


The author discusses the importance of engineering and the need for engineers to play more of a role in society. To underscore his point he proposes a TV program about engineers.<<ETX>>


Invited commentary on 'Antimicrobial resistance: the major contribution of poor governance and corruption to this growing problem' by P. Collignon et al.

Bacterial resistance to antibiotics has long left the scientific and professional laboratories to become a rather dramatic public health emergency. It is now perceived as a problem that affects the general public inasmuch as the number of multidrug resistant bacteria is rapidly growing and consequently the treatment options for these bacteria are very few. This phenomenon is not limited to hospitals and nursing homes, where it is certainly more acute, but involves the entire community.

Similarly, the corruption in most societies is also perceived as a devastating phenomenon that increases inequality and puts at risk the progress if not the whole peaceful survival of civil societies. In Europe, for instance, the efforts made to build up economic and in perspective a political union based on the same general governmental rules are severely threatened by, among other factors, the huge difference in the level of corruption perceived by the citizens of the different European countries.1

While both antibiotic resistance and corruption perception appear to be on the rise, that the two phenomena could be under statistical correlation in Europe could sound as a surprise. In the March issue of PLoS One, an article authored by Collignon and collaborators2 highlights the possible relationship existing between antibiotic resistance and corruption. To investigate this relationship, the authors move from the working hypothesis of the existence of additional factors other than the well-investigated ones (such as, for instance, the use or rather the abuse of antibiotic usage) outlining the continuous rise of antibiotic resistance. For this reason, they include in their analysis other political, social and economic variables assuming that these factors could influence the development of antibiotic resistance.

In order to test their hypothesis, the authors developed a mathematical model that was applied to retrospectively evaluate several parameters including the gross domestic product (GDP) and the quality of governance (G) as an expression of the control of corruption in 28 European countries over the period 1998-2010.3 The choice of Europe was because this is the only world region where it is possible to obtain complete and reliable data necessary for developing a valuable and predictive mathematical model.4

Several economic, political and social parameters were related to the major pathogens resistant to several classes of antibiotics, i.e. MRSA, third generation cephalosporin-resistant, gram negative bacteria, MDR Pseudomonas aeruginosa, vancomycin resistant Enterococcus, penicillin-resistant pneumococci. The quality of governance was defined as control of corruption in the civil society and it was measured by a scale of 0 to 6, where 0 is the lowest level of control of corruption and 6 the highest one.

Comparing the level of antibiotic resistance in the different European countries with the level of governance as a proxy of the control of corruption in an individual nation, a statistically significant negative correlation (r = -077) between a low degree of control of corruption and the incidence of a high degree of antibiotic resistance has clearly emerged. In other words, in the countries where the control of corruption is more effective, antibiotic resistance is lower, while the opposite is true in countries where less control is exercised. The correlation between consumption of antibiotics and development of resistance in the 28 European countries does not reach the level of statistical significance (r = 0.40) although there is a tendency to support this correlation. There is no correlation between the GPD and the development of antibiotic resistance.

The authors conclude that the quality of corruption governance is responsible more than the consumption of antibiotics for the development of antibiotic resistance in the European country. They speculate that the reasons for this do not only depend on the development but also on the spread of resistant strains in humans as well as in animals as a consequence of the failure to control corruption. In fact, it is also considered that an increase of one unit in the index of control of corruption (G) would lead to a consequent significant reduction of antibiotic resistance in an individual nation. The logical and natural consequence of all this is that fighting corruption and improving governance are effective measures for reducing antibiotic resistance in a country, perhaps better than other measures that have not been so effective, so far.

The authors correctly admit that the same correlation between corruption and antibiotic resistance could have been observed in other areas of the world were the quality of data available is the same as in Europe. This consideration allows hypothesizing that the conclusions reached in Europe may be applicable in other areas of the world and that the control of corruption as a measure of control of antibiotic resistance may play a universal role. Although the mathematical model is well designed, it is still a retrospective study and by no means could provide a demonstration about the causality of the link between corruption and antibiotic resistance.

In conclusion, the most relevant aspect of this article is that for the first time a correlation between a political and social factor such as corruption and a biologic factor such as antibiotic resistance is statistically assessed and proved to correlate. The authors of this article have launched a provocation: it will be interesting if the government, especially of those countries where corruption is higher, will promote studies to validate or reject the results of this study. We add another provocation: looking at the countries with low and high scores in corruption and knowing the reported levels of tax evasion in those countries, could a positive correlation be found also between the level of tax evasion and antibiotic resistance? Maybe it is that the levels of respect of the general rules of living and reasoning together underscore and explain the potential relationships of such different phenomena?


A compressible carbon aerogel with not only super mechanical performances but also ultrahigh linear sensitivity is fabricated from MXene nanosheets and cellulose nanocrystals (CNCs).


Conde, Mary sa Tales from the Heart: True Stories from My Childhood. Trans. from the French by Richard Philcox. Soho Press Inc. 2001. 144pp. ISBN 1569472645. A series of short, vignette-like narratives subtly looped together to suggest the coherent story of a life, Maryse Conde's childhood memoir Tales From the Heart seems in more ways than one to be an aspect of her novelistic art. Each "tale" identifies a rite of passage in the artist's development. Not surprisingly, then, the book recalls the general concerns of Conde's fiction: history, mimicry and the ironic problematics of identity; the fraught, ironic relationship with Africa that so distinguishes her work from more romantic imaginings of the 'mother continent'; class/colour divides; the issues of femaleness in colonial space and time; the rewriting/retrieval of narratives submerged within canonical texts and discourses. At the same time, this personal testament is nuanced by an evocative sense of place (the Guadeloupe of her childhood, a Guadeloupe that is both French and totally Caribbean/colonial) and by a poignant sense of character and human suffering. Conde makes little attempt to distinguish between the voices of her childhood persona and the adult voice rehearsing memory. At times the reflections that she presents as the child's become questionable, both because of their sophistication and because of the text's ventriloquism. An example of these questionable reflections is the tale of her early rebellion against her parents' colonial-bourgeois values (in Conde's allusion, forms of Fanon's black skin, white masks). A very young Maryse, puzzled by the contradictions in her parents' behaviour (the mismatch between their insistent black pride on the one hand, and a dreadful, inverted colonial sycophancy on the other) asks her elder brother for an explanation, and is given the term "alienated individuals." The child struggling to make sense of this, "came up with a vague theory. An alienated person is someone who is trying to be what he can't be because he does not like what he is. At two in the morning, just as I was dropping off, I swore in a confused sort of way never to become alienated" (7). There is nothing unbelievable in this. What may be startling is the assertion that follows: "As a result, I woke up a completely changed little girl" (7). The change Conde speaks of manifests itself in the recalcitrance one would expect in a teenager, not a small child, analyzing parental hypocrisy. But perhaps one is surprised only if one forgets what Conde's story constantly highlights: that she was an exceptional child. This narrative, "Family Portrait," placed at the beginning, signals Conde's project to give personal witness to what it is like to grow up colonized, and how one learns to discern, reject and survive. The narrative is painful. We are told Conde's parents (black, middle class) made annual pilgrimages to France, in proof of a Frenchness that is constantly elusive and constantly denied: ...the garcons de cafe would hover around us admiringly like honey bees. Setting down the diabolos menthe, they never failed to come out with, "You speak excellent French, you know." My parents bore the compliment without turning a hair or smiling, merely a nod of the head. Once the garcon had gone, they turned to us as witnesses, "Yet, we're as much French as they are," my father sighed. "Even more so," my mother continued vehemently... "We're more educated. We have better manners. We read more. Some of them have never left Paris, whereas we have visited Mont Saint- Michel, the Riviera, and the Basque coast." There was something pathetic in this conversation, which, though I was very young, upset me. (4-5). In the same way that she seems to confound the barriers between child and woman, Conde inhabits with royal license worlds and experiences in which she could not possibly have been present. The story of her conception and birth is recounted with the certainty of a privileged eyewitness: Once she had gotten over the shame of being caught in flagrante delicto in the pleasures of the flesh at her respectable age, my mother was overjoyed at her condition. …


Excerpt This paper is a report of six cases of pernicious anemia, four cases of secondary anemia, one case of atypical secondary anemia, and one case of Hodgkin's Disease treated by a diet rich in ...


Wiskott-Aldrich Syndrome (WAS) is a genetic disease linked to the X chromosome, characterized by recurrent infections, autoimmunity, malignancy, eczema and hemorrhage. Mutations in the WAS gene alter the coding of the WASp protein, expressed mainly in the cytoplasm of hematopoietic cells, with functions of actin polymerization, signaling events and cytoskeletal rearrangement. According to severity, there are four phenotypes described: classical form (WAS), X-linked thrombocytopenia (XLT), X-linked intermittent thrombocytopenia (IXLT) and X-linked neutropenia (XLN). Only the mutation analysis was shown to be of limited value in predicting the clinical phenotype. However, the analysis of protein expression in lymphocytes has been very successful in predicting this phenotype. On the other hand, it is not yet known which patients with XLT phenotype may progress to the classical form and for this reason there are controversies about the indication of bone marrow transplantation in these patients.This study aims to perform a clinical, laboratory and molecular analysis of pediatric patients diagnosed with WAS under our clinical follow-up at Hospital das Clínicas of UNICAMP and follow-up patients at other Brazilian Reference Centers of Primary Immunodeficiency.


PURPOSE
To quantify the incidence and type of complications after LASIK for the correction of myopia with special consideration to the time lapse after surgery and the possible consequences regarding high-contrast sensitivity and other modalities of visual acuity.

MATERIAL AND METHODS
Between January 1995 and April 1997, 125 eyes of 88 patients with myopia greater than -6.0 D who could not wear contact lenses were operated on at our institute. In this prospective study the patients were examined consecutively preoperatively as well as postoperatively at day 4 and months 1, 3 and 6. The complications were divided into three groups (intraoperative, early postoperative and late postoperative).

RESULTS
Our complication rate was 7.2% (loss of 2 lines of visual acuity)--with cutting artifacts related to the microkeratome, wrinkling of the flap and epthelial ingrowth.

CONCLUSIONS
LASIK is a microsurgical procedure that requires adequate experience and the desire by the surgeon for self-evaluation. In spite of the good clinical results in the correction of high myopia the complication rates seems still to be too high. This should be the objective for further improvement primarily related to the microkeratomes.


A backlight device is incorporated into a liquid crystal display device so as to illuminate a liquid crystal panel from a backside. The backlight device includes a light-guiding plate emitting a light, which is incident on a side surface thereof, from a front surface, and a reflector arranged along the side surface of the light-guiding plate so as to reflect a light from a light source accommodated inside thereof and guide the light to the side surface of the light-guiding plate through an opening part. A least one minute protruding part, which protrudes in a direction parallel to the side surface of said light-guiding plate, is formed on an edge part of the opening part of the reflector facing the light-guiding plate. The side surface of the light-guiding plate is brought into contact with the protruding part of the reflector when the light-guiding plate moves toward the reflector.


Recently published experimental data on the presence of different types of angiotensin receptors in melanoma tissue and in breast cancer, for example, are undoubtedly alarming and indicative because Sartan therapy (in certain groups of patients) may be a risk factor for the patients themselves. The reason for this is the ability of the specific group of drugs to promote carcinogenesis by blocking certain types of receptors, presented in certain types of tumors. The available in vivo and in vitro data in the world literature on the influence of antihypertensive drugs (Sartans and Thiazide diuretics) on melanogenesis and development of other cancerous forms, although disputed, are numerous. Even more disturbing are the further data in the medical literature on the development of multiple tumors after administration of Sartans alone or in combination with hydrochlorothiazide. According to other literature data, even monotherapy with the already mentioned diuretichydrochlorothiazide, could be seen as a possible key or risk factor for the development of cutaneous melanoma. We present a clinical case of a 67-year-old patient with anamnestic data for systemic antihypertensive therapy with a combined preparation containing Valsartan / hydrochlorothiazide 160 mg / 12.5 mg for the period from the end of 2011 to March, 2020, came on occasion of a prophylactic dermatological examination. The examination found a pigmented lesion in the right torso, clinically and dermatoscopically suspected of thin cutaneous melanoma. According to the anamnesis and available documentation, it is clear that within this combined antihypertensive medication, the patient has developed two additional neoplasms in the recent past: choroidal melanoma and colorectal carcinoma successfully treated surgically. To what extent, the shared data (on the occurrence of multiple tumors after combination treatment with antihypertensives such as sartans and thiazide diuretics) would lead to the necessary and desirable rethinking of therapeutic strategies for the treatment of hypertension and clarification of the mechanisms at molecular level, at this moment remains unclear. But in practice it should be highly recommended.


The Handicapped Action Committee (HAC) is a non-profit Society that is run by disabled people for disabled people. The HAC develops and maintains projects to promote its goal – the integration of people with disabilities and their full participation in the community. Mobility is vital in achieving integration and inclusion into the community. Transportation is essential in providing the needed mobility, especially in communities where many of the facilities and services are geographically dispersed. Cost is always an important factor in influencing projects designed to improve the quality of life for disabled people.


Huangbuling gold deposit is located in the hanging wall of Fenghuangshan-Huangbuling fault of Zhaolai gold belt in northwestern Jiaodong.It is made up of 18 ore veins in different scales.The result indicates that CO2 inclusion,CO2-bearing ternary inclusion and gas-liquid inclusion intergrowth exist in quartz from NE ore veins.Laser Raman spectroscopic analysis shows that CO2 inclusion's main composition is CO2,CO2-bearing ternary inclusion can be classed into IIa type(CO2 50% in percentage) and IIb type(CO2 50% in percentage),gas-liquid inclusion composition is composed of vesicle and water.Analysis of Linkam THMS-60 type hot and cold stage shows that: the CO2 inclusion's homogenization temperature ranges from 22.46℃ to 27.7℃,IIa type's homogenization temperature ranges from 175℃ to 355℃ while the peak value between 235℃ to 325℃,IIb type's homogenization temperature ranges from 195℃ to 385℃ while the peak value between 220℃ to 295℃ and gas-liquid inclusion's homogenization temperature ranges from 115℃ to 240℃ whose three peak values are 115℃~205℃,130℃~160℃ and 190℃~340℃.The salinity of fluid inclusions is 0.23~11.0 wt% NaCl while the pressure is 1 100×105 Pa.The NE ore veins of Huangbuling gold deposit belong to mesothermal vine type gold deposit.


The work aims to analyze and examine renewable energy sources (RES) to develop interconnected energy efficiency and energy consumption management system by integrating the software-defined machine-to-machine (M2M) communication. The article's objectives include analysis of using RES as alternative raw materials for electricity production, the study of intelligent technologies for integrating RES into monitoring and control systems, research of devices and methods for monitoring energy production and consumption, analysis of sensor application for automation of control systems in the energy sector, a study of data transmission and information processing rates. The study results showed that the data transfer rate was delayed by 6 seconds to process 1,000 MB of information. It has been proven that wind energy can be used most efficiently within a 12-hour daily cycle, in contrast to tidal energy and solar energy. It is shown that due to the cyclical nature of obtaining energy from renewable sources, they do not fully provide energy to a large city, on the basis of which it is necessary to additionally use other energy sources. Three different types of power generation facilities were examined and compared. Wind farms were found to have the highest potential for electricity generation, amounting to 1,600-1,700 kW.


Security databases such as Common Vulnerabilities and Exposures (CVE), Common Weakness Enumeration (CWE), and Common Attack Pattern Enumeration and Classification (CAPEC) maintain diverse high-quality security concepts, which are treated as security entities. Meanwhile, security entities are documented with many potential relation types that profit for security analysis and comprehension across these three popular databases. To support reasoning security entity relationships, translation-based knowledge graph representation learning treats each triple independently for the entity prediction. However, it neglects the important semantic information about the neighbor entities around the triples. To address it, we propose a text-enhanced graph attention network model (text-enhanced GAT). This model highlights the importance of the knowledge in the 2−hop neighbors surrounding a triple, under the observation of the diversity of each entity. Thus, we can capture more structural and textual information from the knowledge graph about the security databases. Extensive experiments are designed to evaluate the effectiveness of our proposed model on the prediction of security entity relationships. Moreover, the experimental results outperform the state-of-the-art by Mean Reciprocal Rank (MRR) 0.132 for detecting the missing relationships.


This study presents the inaugural analysis of income mobility in North Macedonia from 1995-2021 using the Mixing Time and Mean First Passage Time (MFPT) metrics. We document larger mobility (in terms of Mixing Time) during the '90s, with and decreasing trend (in terms of mobility) until 1999. After this year the Mixing time has been consistent with a value of around 4 years. Using the MFPT, we highlight the evolving challenges individuals face when aspiring to higher income tiers. Namely, we show that there was a noticeable upward trend in MFPT from 1995 to 2006, a subsequent decline until 2017, and then an ascent again, peaking in 2021. These findings provide a foundational perspective on the income mobility in North Macedonia.


"What is the worth of moral values that only inform easy decisions but are impotent in more difficult circumstances?" Yet should one not at times tailor one's moral views to suit circumstances? Drawing on his personal business experience in Taiwan Peter Huang reflects on the ethical issues raised by trying to do business honestly in a climate of organised crime. Currently completing his MBA at London Business School, he is of Taiwanese origin and returned there from Canada to found his own design company.


The artificial aging of LM-26[Al-8.5Si-2Cu-0.3Mg] alloy at temperature, namely 150, 200 and 250°C, is investigated through the use of ultrasonic velocity measurements. More importantly, three stages of aging behavior such as under aging, peak aging and over aging were observed during artificial aging of LM-26. It was found that over extended period of time and temperature, the ultrasonic velocity increase linearly with respect to time, furthermore it is stay constant and then after start to constantly reduce. The purpose of present study is to explore the possibility of using ultrasonic velocity measurements and Macro hardness [HRM] for investigating and correlating them for a complete characterization of the precipitation behavior in a LM-26 alumium alloy. The present study reveals that both these techniques can be used for monitoring the strengthening process as a result of the precipitation on ageing at dissimilar times and temperatures.


In this paper,ring-opening polymerization of six-membered cyclic carbonate including 2,2-dimethyl trimethylene carbonate(DTC)and trimethylene carbonate(TMC)initiated by natural amino acids were investigated in detail.Results showed that polymers obtained have high yield and molar weight when polymerization carried out in the presence of neutral amino acids with two functional groups.The number-average molecular weight(Mn)of poly(2,2-dimethyl trimethylene carbonate)reaches 18 900 g·mol-1 with molar ratio of DTC to L-phenylalanine 200∶1 at 110℃ for 60 h and the Mn of poly(trimethylene carbonate)reaches 15 000 g·mol-1 with molar ratio of TMC to L-leucine 100∶1 at 90℃ for 24 h.


Abstract Among the most surprising claims in The Methods of Ethics is Sidgwick's assertion that his key ethical axioms are corroborated by Kant. This article analyses Sidgwick's claim that his axioms of justice and benevolence closely correspond to particular features in Kant. I shall argue that his claim of agreement with Kant was a serious overstatement. In particular, the restrictions which Sidgwick places on his acceptance of Kant's universal law formula of the categorical imperative (FUL) seem to call into question whether the alleged convergence with the axiom of justice has a solid basis. Further, Sidgwick seemed unaware of a crucial aspect of Kant's conception of the humanity formula that constitutes a substantial divide between their views on benevolence. The upshot is that the divide between Kantian and Sidgwickian ethics appears deeper than Sidgwick seemed to realize. This analysis is confirmed by Sidgwick's famous worries regarding freedom and the existence of God in Kant's work.


The method of comfortable degree curve is used to determine the days of rather cold,cold, little cold and cool,and the most suitable period for tourism. The comfortable hours and hot hours are determined by calculation of effective temperature. The results show that the most suitable days for tourism in this Nature Reserve is averaged for 86 days falls from April to September, and concentrated in the period of June to September. During the period, about 2 864 hours are comfortable for human body.


An access point acts as the main radio transmitter for your wireless LAN. Access points translate network traffic into radio signals and transmit that signal to wireless enabled computers. An access point can also be connected to an existing wired network via a cable in order to allow wireless enabled computers access to a wired network. You can have more than one access point on a particular network.


'THhis,' wrote Mr Mackenzie a few weeks ago, 'is the first formal report on the working of the Library; it covers a period of rather less than a year—from 16th September, 1963, when the Librarian arrived in Lancaster with half a dozen books in his brief‐case, until 31st July, 1964, when an effective library was in operation with a stock of over twenty thousand volumes.' There, if we forgive Mr Mackenzie for his poet's licence, is the essence of the accommodation problem with which each new university is being faced. We are not being asked to expand existing book and reader accommodation, or to replace it by new building. We have started with nothing and we have to be operational a year or eighteen months afterwards.


This paper discusses the global education envir onment,the subjects-centered education,the informative education carrier,the vir tual education and the complicated education information reflected by the ideolo gical and political education of the colleges and universities network in the ne w situation;it also studies the key links to be grasped in the process of the id eological and political education network construction in colleges and universit ies.


In a preliminary study of 21 febrile episodes in neutropenic patients ceftazidime used as empirical treatment in doses of 3 grams per day succeeded in controlling fever in 74 per cent of the cases. Laboratory studies performed in patients with Gram-negative septicaemia showed clinically effective plasma concentrations of the antibiotic. A trial of ceftazidime (3 g/day) administered alone or combined with amikacin or vancomycin is currently in progress in two medical centres. No statistically significant conclusions could be reached from an intermediate study.


Objective To investigate Urumqi,Han,Uygur gastroesophageal reflux disease(GERD) disease characteristics,and potential relative risk factors.Methods Five hundred Han and five hundred Uygur residents respectively for health examination were included,each of them accomplished a GERD questionnaire(GerdQ),then accepted endoscopy inspection and proton pump inhibitor test.Results(1)There were 130 Han Chinese(incidence 26%) and 175 Uygur(incidence 35%) GERD were detected according to GerdQ standard;there were 121 Han Chinese(incidence was 24.2%) and 155 Uygur(incidence was 31%) GERD were detected according to classic diagnostic criteria.(2) Uygur GERD incidence was higher than that of Han nationality(P0.01),Uygur male GERD incidence was higher than that of Uygur female(P0.005) and Han nationalyty male(P0.01).(3) Female GERD of two populations were all related to occupation;Uygur male GERD was related to occupation and drinking;Han nationalyty male GERD was related to occupation,drinking and meat.Conclusion GerdQ possesses a good compatibility with classic diagnostic criteria and can be used to clinical diagnosis for GERD;Uygur GERD incidence is higher than that of Han nationalyty;gender,occupation,drinking and meat are the main risk factors of GERD in Urumqi.


Synthetic aperture imaging radiometers (SAIR) are potential powerful instruments for high-resolution observation of
planetary surfaces at low microwave frequencies. This article deals with the reconstruction of radiometric brightness
temperature maps from SAIR interferometric measurements. It is demonstrated that the corresponding inverse problem
is not well-posed, unless a regularizing constraint is introduced in order to provide a unique and stable solution.
A regularizing approach is presented by referring to the angular resolution of the instrument. To illustrate the theory,
numerical simulations are carried out for the SMOS space mission, a project led by the European Space Agency.


In this research, the concurrent multiband LNA that works at four frequency centers of 950 MHz, 1.85 GHz, 2.35 GHz, and 2.65 GHz will be designed and analyzed. The multiband LNA uses transistor HJ-FET NE3210S01 in cascode structure with self bias and inductive degeneration topology with resonator LC. The performances of multiband LNA are simulated by Advance Design System (ADS). It is shown from the simulation results that, at four frequency centers of 950 MHz, 1.85 GHz, 2.35 GHz, and 2.65 GHz, the S21 achieves 21.77 dB, 17.88 dB, 16.71 dB, and 15.85 dB respectively, the S11 achieves -23.23 dB, -20.46 dB, -17.93 dB, and -19.69 dB respectively, the NF achieves 0.73 dB, 0.69 dB, 0.68 dB and 0.75 dB respectively.


Abstract A probabilistic convergence structure assigns a probability that a given filter converges to a given element of the space. The role of the t-norm (triangle norm) in the study of regularity of probabilistic convergence spaces is investigated. Given a probabilistic convergence space, there exists a finest T-regular space which is coarser than the given space, and is referred to as the 'T-regular modification'. Moreover, for each probabilistic convergence space, there is a sequence of spaces, indexed by nonnegative ordinals, whose first term is the given space and whose last term is its T-regular modification. The T-regular modification is illustrated in the example involving 'convergence with probability λ' for several t-norms. Suitable function space structures in terms of a given t-norm are also considered.


Improving perinatal and maternal mortality rates in developing countries tends to be viewed as being entirely dependent on the introduction of Western health-care systems. No-one would wish to deny the tremendous benefits such efforts can bring, but in the past too little attention has been paid to the potentially harmful effects that may also be produced. This article describes the author's experience of working in the delivery suite of a government-run hospital in Nepal. It highlights the impact of procedures — all of which are now discredited in the West — on women's and babies' experiences of birth and in many cases, on their postnatal health. The impact this has had on the author herself has led her to set up a small project to share some of our current knowledge and experience of a more holistic approach to child-bearing with colleagues in Nepal.


ON WEDNESDAY, MARCH 10, 1993, THE SENATE JUDICIARY COMMITTEE VOTED unanimously to endorse the nomination of Janet Reno to be the chief law-enforcement officer of these United States. That committee, which included women for the first time--thanks incidentally to the Anita Hill-Clarence Thomas contretemps -- engaged in a two-day love feast before sending the nomination to the Senate floor, where the full Senate voted 98--0 to confirm her nomination as attorney general. She was sworn in last Friday. A stranger to this country, who had not set foot on our shores until late February of this year, might mistakenly believe that Miss Reno's ascendancy to her new position was based solely on her admittedly excellent record as the chief prosecutor in Dade County, Florida. Those of us who are taking time to reflect upon the concept of class, race, and gender know differently. My chief concern is directed toward the marginalized women at the lower end of the social scale. The Baird--Wood--Reno story, however, gives us a very current, sharply focused opportunity to see how gender can play a pivotal role when reviewing the qualifications of persons to fill the highest executive office within our federal justice system. I do not have to defend Zoe Baird's employment of undocumented aliens in order to assert that sexism pervaded the entire episode with both Baird and Judge Kimba M. Wood. Baird had admitted violating the law; arguably, that alone should disqualify her for such a high post. Judge Wood, however, had employed an alien for childcare at a time when it was legal to do so. She had paid all required taxes and filed all required forms. Because she chose to have a career, child care was a necessity. Her forced withdrawal as a nominee for attorney general clearly reflected the gender tilt imposed and maintained by the ruling male establishment. It is because her qualifications to do the job were so outstanding that the tragedy of gender bias becomes more compelling. It is small comfort that the president finally turned to another woman, without children or a family to support, in hopes of finally filling the post. We should not deceive ourselves that the unanimous confirmation of Janet Reno is anything more than a bright, shooting star across the heavens within a galaxy of bias, repression, and intolerance on matters of gender. With this as background, I would like to consider several cases from my own experience that may help to place the concept of class, race, and gender in a real perspective. The present position of this nation on matters of racism, sexism, and classism deserves our serious attention. When I think of the interrelationship between these terms and, more particularly, their impact upon our system of criminal justice, one case with elements of all three quickly comes to mind. The Pennsylvania Superior Court had occasion to consider an appeal involving a sentencing issue, where the defendant argued that her sentence on several petty-theft charges had been harsh and excessive.(1) The defendant, Cynthia Ellman, was a poor, African-American woman who had been caught shoplifting on three separate occasions. Ellman had attempted to shoplift four packs of cigarettes on one occasion, and a carton of cigarettes on a second attempt, both at a Loblaw's grocery store in Erie County, Pennsylvania. She tried to shoplift a pair of designer jeans while on still another foray into a Value City discount store in a shopping mall in the same county. The full extent of her bounty, had she been successful in getting away from the store each time without being caught, would have been 16 packs of cigarettes and a pair of denim jeans with a total value of less than $32.00. In Pennsylvania, we have recidivist provisions in our retail-theft statute; a third offense for shoplifting is classified as a third-degree felony, permitting a term of imprisonment of seven years. This poor black woman was sentenced by a judge to two concurrent sentences of 2 1/2 to 5 years of imprisonment on the separate attempts to shoplift the cigarettes. …


The major results of a study aimed at reducing the monolithic microwave circuit size are presented. The paper first reports the design and performances of new low-coupling coplanar circuits, which are suitable for both monolithic and hybrid applications and show a very flat coupling and a high directivity over a broad frequency range (e.g., 5 + 13 GHz). Then, experimental results and design data are presented for new low-size slow-wave couplers. Finally, the practical use of the slow-wave approach for overcoming some well known problems in the monolithic circuit design is described and the performances of a two-stage medium power monolithic amplifier, using a slow-wave line length in the interstage matching network, are stressed.


In this paper,the photosynthetic characteristics of the flag leaf of wheat cultivar and semiwheat was researched.The results indicated that cultivar's photosynthetically active radiation(PAR) and leaf temperature(TA) had stronger restriction function than semiwheat's,and interceller CO_2 concertration(CO_2int) had limiting function in semiwheat.Pigment contents of flag leaf in semiwheat were higher than cultivar's,while semiwheat's MDA content was higher than cultivar's,SOD activity of flag leaf in semiwheat was lower than cultivar's.The result showed there was the close relation between high photosynthesis rate and low resistance in semiwheat.


Private schools have proliferated across the country in the past two years, now numbering more than twelve hundred from the elementary to the college level. The large-scale rise of private schools has brought forth both praise and censure. A number of related questions need to be clarified for this new educational phenomenon to be correctly understood and managed.


Purpose
This paper aims to explain the regulations in Indonesia that apply to lawyers and other professional advisers in terms of their obligations as reporting parties of suspicious financial transactions with respect to money laundering and other financial crimes. As lawyers and other professional advisers offer services to the business community in Indonesia, they are vulnerable to becoming parties to illegal business transactions. The results could lead to bribery, graft, tax crime and corruption in Indonesia.

Design/methodology/approach
This paper explores and analyzes the obligations of lawyers and other professional advisers under Indonesian law, with particular reference to their obligations as reporting parties in efforts to prevent economic crime within the country's business community.

Findings
Lawyers and other professional advisers, as reporting parties, can be viewed as the gatekeepers that inhibit economic and financial crimes. Consequently, a new perspective is needed for all of the legal professions so that they can protect themselves from the risks of being targeted by nefarious clients/offenders. To strengthen the role of these advisers, it is recommended that both a code of ethics and know your customer principle to be implemented.

Practical implications
This paper can serve as a resource that explores the functions of lawyers and other professional advisers as reporting parties whose aim is to prevent financial and economic crime in Indonesia.

Originality/value
This paper encourages lawyers, other professional advisers, and public and private institutions to implement a code of ethics, and also integrity and professionalism, with a view to preventing economic and financial crimes. According to the code, the functions and obligations of lawyers and other professional advisers include discouraging such offenses. The code becomes effective when legal professionals adhere to legal ethics and integrity.


Nowadays to compete effectively in the e-commerce world, a company must structurally transform its internal foundation using amount IT/IS. Such e-business transformation also entails tight realignment of business strategy with IT strategy, setting up the necessary infrastructure, streamlining front-end and backend business processes, managing new relationships and partnership, and taking into consideration that how to transform effectively issues. The main purpose of this study is to examine the effective factors of organizational learning ability in the e-business transformation from partnership, organizational context different scopes (ex, top managers' support, centralization, task coordination, communication, EB maturity). The research model and hypothesis was formed by the theories that based on literature and management. Data were collected using a questionnaire sent to the IS directors of 820 large companies in Taiwan with 202 usable responses were received. Survey results indicate that the partnership and organizational context-related factors relatives organizational learning ability influent the EB implementation effectiveness on the EB transformation significantly.


In many important applications of precision medicine, the outcome of interest is time to an event (e.g., death, relapse of disease) and the primary goal is to identify the optimal individualized decision rule (IDR) to prolong survival time. Existing work in this area have been mostly focused on estimating the optimal IDR to maximize the restricted mean survival time in the population. We propose a new robust framework for estimating an optimal static or dynamic IDR with time-to-event outcomes based on an easy-to-interpret quantile criterion. The new method does not need to specify an outcome regression model and is robust for heavy-tailed distribution. The estimation problem corresponds to a nonregular M-estimation problem with both finite and infinite-dimensional nuisance parameters. Employing advanced empirical process techniques, we establish the statistical theory of the estimated parameter indexing the optimal IDR. Furthermore, we prove a novel result that the proposed approach can consistently estimate the optimal value function under mild conditions even when the optimal IDR is non-unique, which happens in the challenging setting of exceptional laws. We also propose a smoothed resampling procedure for inference. The proposed methods are implemented in the R-package QTOCen . We demonstrate the performance of the proposed new methods via extensive Monte Carlo studies and a real data application.


Clinical therapeutics are becoming increasingly reliant on data science and computational data analytical tools to predict drug behavior in unobserved conditions or populations. These in silico approaches, collectively termed "pharmacometrics", derive biological meaning from the analysis of pooled drug concentration vs. time (CvT) datasets. However, the field lacks standardization for pharmacokinetic (PK) data description and sharing, instead requiring deep dives into the literature and expert data annotation for aggregate data mining. Here we introduce a minimum information sharing standard for PK studies composed of three categories (Intervention, System, and Effects) and implement this standard in the development of a web-based PK database: the HIV Pharmacology Data Repository (PDR). We demonstrate the utility of the HIV PDR by computational modeling of aggregated and curated CvT data extracted from the HIV PDR.


Freedom to work is a fundamental principle of labor law and includes the right of individuals, in accordance with their abilities, to chooses employment or independently to perform certain activities. The introduction of bans, among which include the prohibition of competition is restricting the freedom of labor. The paper outlines the nature and effect of the prohibition of competition in the labor law with extract of the most important legal comparative elements. The aim is to show that the legitimacy of the prohibition of competition involves striking a balance between the business interests of the employer and the employee's freedom to work. The conclusion is that domestic law does not provide sufficient imperative protection of employees in the context of contracting prohibition of competition, with the suggestion that it is expedient to specify the minimum amount of compensation for the duration of this ban to employment.


An investigation of the separation of alkanes, alkenes, and cycloalkanes from benzene in coke oven gas was presented. The absorption index was determined for benzene and n-octane as a function of temperature in methylnaphthalene, coal oil, solar oil, polyalkylbenzenes, tetraline, and 1,7-dimethylnaphthalene by gas chromatography. It was concluded that the best absorbers for the recovery of benzene were tetraline and coal oil. The most efficient absorber present in wash oil was methylnaphthalene. (JMT)


STAFF ARE set to learn by the end of the year which NHS trusts are to test run the new pay system.