17119 Background: Sorafenib is an inhibitor of multiple kinases including Raf-1 (C-Raf), b-Raf and pro-angiogenic tyrosine kinases (VEGFR-2/3 and PDGFR-β) and showed preclinical activity against NSCLC cell lines. Its anti-tumor activity may be attributable to inhibition of proliferative signaling through the RAS/Raf/MEK/ERK pathway and its anti-angiogenic effects. In NSCLC, the proliferation signaling of the Ras/Raf/MEK/ERK pathway is increased due to the increase in K-ras mutations. We initiated a single agent sorafenib trial in patients (pts) with relapsed NSCLC to assess clinical response and translational endpoints in tumor biopsies.

METHODS
This phase 2 trial uses a two-stage design targeting an objective response rate (RR) which can rule out 5% in favor of a more desirable 20% RR. Eligibility criteria: Pts with recurrent NSCLC with measurable disease who have received only one prior chemotherapy regimen, ECOG 0-1. Pts receive Sorafenib 400 mg bid continuously on 28-day cycle. Responses were evaluated every 8 weeks (wks) according to RECIST criteria. Dynamic contrast enhanced MRI (DCE-MRI) and tumor biopsy are performed before cycle 1 and at C1D15 to study early changes in tumor vascularity and translational endpoints.

RESULTS
6 pts are evaluable for toxicity and 5 pts are evaluable for response. Best Response: 1PR (41% tumor reduction at wk 8, remained in PR until wk 28), 1 PR (unconfirmed) at wk 3, 2SD (16 and 19 wks respectively) and 1PD after 8 wks of treatment. Skin toxicity: Acne like drug-related rash (5 pts), hand-foot syndrome (6 pts), keratoacanthoma (1pt) and vasculitis (1pt). All skin toxicities are G1 or G2 and have responded to temporary withdrawal of Sorafenib and supportive care. Hypertension occurred in 1 pt (G2). No G4 toxicities have been observed. G3 toxicities include: anemia (1 pt), hyponatremia (2 pts), and nausea (1 pt). DCE-MRI results: 1 pt on C1D15 showed decrease in permibility parameters (ktrans and kep) and tumor size. DCE-MRI from the other 2 pts (1 PD, 1 SD for 16 weeks) showed no decrease in the permeability parameters.

CONCLUSIONS
Sorafenib appears to be well-tolerated and active against relapsed NSCLC. Preliminary evidence of objective response warranting second stage accrual. No significant financial relationships to disclose.


Abstract A titan of popular culture and commerce, the positive trend lines of eSports audiences, participation and commercial output run counter to those of many traditional sports. Despite the reluctance of the uninitiated to consider them 'sports,' eSports continues to evolve, grappling with similar issues emerging from advancements in technology, ethics, inclusion, and the incursions of brands into this identity-driven entertainment industry. These issues and more warrant the attention of sports management scholars. Thus, a deeper scholarly understanding is achieved through examining a diverse range of perspectives, including understanding eSports players themselves, how they interact, the health and wellness challenges they face, and how the industry is impacted by the necessary commercial involvement of big brands. In synthesizing these insights with traditional sports management knowledge organisations, brands, and policy makers can contribute to fostering an industry that has captured the interests of many millions across the globe.


We present a completely new technique to read out the CCD matrix that can achieve much lower noise than classical techniques used since the 1970s. This technique is based on digital analysis of the CCD's output signal instead of analog filtering coupled to an original filtering method. Despite several attempts carried out in the past to implement digital correlated double sampling, this is the first time that a radical improvement in readout noise performance is shown. This is highly interesting for low light level conditions, where the detector works in the readout‐noise regime and not in the photon‐noise regime. This is particularly the case when carrying out medium‐ to high‐resolution spectroscopy or multiplex (scanning) observations.


Automated driving system - dedicated vehicles (ADS-DVs), specially designed for people with various disabilities, can be beneficial to improve their mobility. However, research related to autonomous vehicles (AVs) for people with cognitive disabilities, especially Autism Spectrum Disorder (ASD) is limited. Thus, in this study, we focused on the challenge that we framed: "How might we design an ADS-DV that benefits people with ASD and their caregivers?". In order to address the design challenge, we followed the human-centered design process. First, we conducted user research with caregivers of people with ASD. Second, we identified their user needs, including safety, monitoring and updates, individual preferences, comfort, trust, and reliability. Third, we generated a large number of ideas with brainstorming and affinity diagrams, based on which we proposed an ADS-DV prototype with a mobile application and an interior design. Fourth, we tested both the low-fidelity and high-fidelity prototypes to fix the possible issues. Our preliminary results showed that such an ASD-DV would potentially improve the mobility of those with ASD without worries.


A C OBJECTIVE: The stress associated with adverse childhood experiences (ACEs) has immediate and long-lasting effects. The objectives of this study were to examine 1) how often pediatricians ask patients' families about ACEs, 2) how familiar pediatricians are with the original ACE study, and 3) physician/ practice characteristics, physicians' mental health training, and physicians' attitudes/beliefs that are associated with asking about ACEs. METHODS: Data were collected from 302 nontrainee pediatricians exclusively practicing general pediatrics who completed the 2013 American Academy of Pediatrics Periodic Survey. Pediatricians indicated whether they usually, sometimes, or never inquired about or screened for 7 ACEs. Sample weights were used to reduce nonresponse bias. Weighted descriptive and logistic regression analyses were conducted. RESULTS: Only 4% of pediatricians usually asked about all 7 ACEs; 32% did not usually ask about any. Less than 11% of pediatricians reported being very or somewhat familiar with the CADEMIC PEDIATRICS opyright a 2016 by Academic Pediatric Association 154 ACE study. Pediatricians who screened/inquired about ACEs usually asked about maternal depression (46%) and parental separation/divorce (42%). Multivariable analyses showed that pediatricians had more than twice the odds of usually asking about ACEs if they disagreed that they have little effect on influencing positive parenting skills, disagreed that screening for social emotional risk factors within the family is beyond the scope of pediatricians, or were very interested in receiving further education on managing/treating mental health problems in children and adolescents. CONCLUSIONS: Few pediatricians ask about all ACEs. Pediatric training that emphasizes the importance of social/emotional risk factors may increase the identification of ACEs in pediatric primary care.


Thank you very much for reading perspectives of irony in medieval french literature. Maybe you have knowledge that, people have search hundreds times for their chosen books like this perspectives of irony in medieval french literature, but end up in malicious downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they cope with some malicious virus inside their desktop computer.


OF THESIS ASSISTED DEVELOPMENT OF MESOPHASE PITCH WITH DISPERSED GRAPHENE AND ITS RESULTING CARBON FIBERS The efficacy of dispersed reduced graphene oxide (rGO) as a nucleation site for the growth of mesophase in an isotropic pitch was investigated and quantified in this study. Concentrations of rGO were systematically tested in an isotropic petroleum and coal-tar pitch during thermal treatments and compared to pitch without rGO. The mesophase content of each thermally treated pitch was quantified by polarized light point counting. Further characterization of softening temperature and insolubles were quantified. Additionally, the pitches with and without rGO were melt spun, graphitized, and tensile tested to determine the effects of rGO on graphitized fiber mechanical properties and fiber morphology.


Interest in underwater welding (UW) is increasing day by day with developments in marine transport, oil and natural gas. Today, many oil rigs are used in the sea. These structures are damaged by collision sand storms over time, and various types of under water welding techniques are used to eliminate these damages. Under water welding presents serious difficulties compared to normal welding techniques. Therefore, researchers are conducting various experiments and applications to overcome these difficulties. The present paper describes the new trends and future welding techniques of under water welding.


A microwave method has been proposed to retrieve the complex permittivity and thickness of lossy dielectric liquids, which result in at least 10 dB attenuation, using reference-plane-invariant reflection scattering (S-) parameters. The CST Microwave Studio simulation program was first used to validate the method. Then, the permittivity and thickness of lossy distilled water sample poured over a polyethylene sample holder were measured from reference-invariant reflection-only S-parameter measurements at the X-band. The method was compared with other methods in the literature to analyse its accuracy.


Simple Summary: development information for in death investigations. While there are phenotypic markers of development, they often do not provide adequate precision and resolution. In order to ameliorate these issues, we have investigated microRNAs as putative markers of immature development in the forensically relevant blow fly, Cochliomyia macellaria . Using RNA sequencing, we were able to identify miRNAs present in immature developmental stages, as well as identify miRNA which were significantly differentially expressed. Through these analyses, we found likely markers of development time, some of which were validated with qPCR methods. As a follow-up, we investigated factors which may influence expression of miRNA throughout development, such as selected genotypic variation and sex. It was very clear that genetic and abiotic factors can impact predictions of age, some of which may exhibit interactions. It is important that future work investigate the markers most robust to genetic effects on development. Abstract: Blow fly development is important in decomposition ecology, agriculture, and forensics. Much of the impact of these species is from immature samples, thus knowledge of their development is important to enhance or ameliorate their effects. One application of this information is the estimation of immature insect age to provide temporal information for death investigations. While traditional markers of age such as stage and size are generally accurate, they lack precision in later developmental stages. We used miRNA sequencing to measure miRNA expression, throughout development, of the secondary screwworm, Cochliomyia macellaria (Fabricius) (Diptera: Calliphoridae) and identified 217 miRNAs present across the samples. Ten were identified to be significantly differentially expressed in larval samples and seventeen were found to be significantly differentially expressed in intrapuparial samples. Twenty-eight miRNAs were identified to be differentially expressed between sexes. Expression patterns of two miRNAs, miR-92b and bantam , were qPCR-validated in intrapuparial samples; these and likely food-derived miRNAs appear to be stable markers of age in C. macellaria . Our results support the use of miRNAs for developmental markers of age and suggest further investigations across species and under a range of abiotic and biotic conditions.


Estrogens profoundly influence the physiology and pathology of reproductive and other tissues. Consequently, emphasis has been placed on delineating the mechanisms underlying regulation of estrogen levels. Circulating levels of estradiol in women are controlled by follicle-stimulating hormone (FSH), which regulates transcription of the aromatase gene (CYP19A1) in ovarian granulosa cells. Previous studies have focused on two downstream effectors of the FSH signal, cAMP and the orphan nuclear receptor steroidogenic factor-1 (NR5A1). In this report, we present evidence for β-catenin (CTNNB1) as an essential transcriptional regulator of CYP19A1. FSH induction of select steroidogenic enzyme mRNAs, including Cyp19a1, is enhanced by β-catenin. Additionally, β-catenin is present in transcription complexes assembled on the endogenous gonad-specific CYP19A1 promoter, as evidenced by chromatin immunoprecipitation assays. Transient expression and RNAi studies demonstrate that FSH- and cAMP-dependent regulation of this promoter is sensitive to alterations in the level of β-catenin. The stimulatory effect of β-catenin is mediated through functional interactions with steroidogenic factor-1 that involve four acidic residues within its ligand-binding domain, mutation of which attenuates FSH/cAMP-induced Cyp19a1 mRNA accumulation. Together, these data demonstrate that β-catenin is essential for FSH/cAMP-regulated gene expression in the ovary, identifying a central and previously unappreciated role for β-catenin in estrogen biosynthesis, and a potential broader role in other aspects of follicular maturation.


Objective: This study aimed to examine the outcomes of COVID-19 and a collapsing economy on the mental well-being (MWB) of the general Lebanese population. Methods: A cross-sectional study was conducted online in May 2020 and enrolled 502 adults. Results: Mental well-being had a mean of 14.80 (14.37; 15.24). A lower MWB was associated with female gender (beta=−1.533 [−2.324; −0.743]), university education (beta=−2.119 [-3.353;-0.885]), fear of COVID-19 (beta=−0.131 [−0.199; −0.063]), fear of poverty (beta=−0.232 [−0.402;−0.063]), verbal violence at home (beta=−3.464 [−5.137; −1.790]), and chronic disease (beta=−1.307 [−2.283; −0.330]). Better family satisfaction (beta=0.380 [0.235; 0.525]) and better financial situation (beta=0.029 [0.003; 0.055]) were significantly correlated with better MWB. In the subsample of workers/looking for a job, additional factors affected MWB: physical exercise (beta =1.318 [0.370; 2.265]) was associated with better QOL, while being a previous waterpipe smoker, being self-employed before the crisis (beta=−1.22 [−2.208;−0.231]), working from home since the economic crisis (−1.853 [−3.692; −0.013]), and worrying about the long-term effects of the crisis on one's employment status (beta=−0.433 [−0.650; −0.216]) were associated lower MWB. It is noteworthy that closure of the institution yielded a borderline result (B = −1.2; p = .094), while the fear of COVID-19 was not significantly associated with MWB (B = −0.054; p =0.192). Conclusion: This study showed that, during the pandemic, economic and other factors, directly or indirectly related to COVID-19, significantly affected quality of life. The fear of COVID-19 and fear of poverty mainly impacted the MWB of the general population. However, the fear of COVID-19 lost its significance among workers, who reported that factors negatively affecting their MWB are directly related to their employment and the already collapsing economy in Lebanon.


The purpose of this chapter is to introduce you to the fascinating story about the evolution of the human brain and especially of its frontal lobes. The story begins in south east Africa some six million years ago and ends with the recent development of modern behavior and mental abilities like symbolic language and creative thinking. Some disadvantages linked to the dangers and demands of a large size brain will be dealt with. A discussion of the anatomical differences between the human brain and that of our close relatives, the African great apes, will follow. Evolutionary advantages linked to the big brain and its advanced frontal lobes will be described, with special focus on the evolution of language and abstract thinking. Our still very limited knowledge about what changes of the human genome, that made it possible to develop modern behavior, is then summarized. The chapter will end by discussing two very old and specifically human mental disturbances, schizophrenia and attention deficit hyperactivity disorder, from an evolutionary perspective.


High energy solid state lasers are being developed for fusion experiments and other research applications where high energy per pulse is required but the repetition rate is rather low, around 10Hz. We report our results on high peak power diode laser stacks used as optical pumps for these lasers. The stacks are based on 10 mm bars with 4 mm cavity length and 55% fill factor, with peak power exceeding 500 W per bar. These bars are stacked and mounted on a cooler which provides backside cooling and electrical insulation. Currently we mount 25 bars per cooler for a nominal peak power of 12.5 kW, but in principle the mounting scheme can be scaled to a different number of devices depending on the application. Pretesting of these bars before soldering on the cooler enables us to select devices with similar wavelength and thus we maintain tight control of the spectral width (FWHM less than 6 nm). Fine adjustments of the centroid wavelength can be done by means of temperature of the cooling fluid or bias current. The available wavelength range spans from 880 nm to 1000 nm, and the wavelength of the entire assembly of stacks can be controlled to within 0.5 nm of the target value, which makes these stacks suitable for pumping a variety of gain media. The devices are fast axis collimated, with over 95% power being collimated in 6 mrad (full angle). The slow axis divergence is 9° (full angle) for 95% power content.


Thymic hyperplasia is frequently observed in Graves' disease. However, detectable massive enlargement of the thymus is rare, and the mechanism of its formation has remained elusive. This case showed dynamic changes in thymic hyperplasia on serial computed tomography images consistent with changes in serum thyrotropin receptor (TSH-R) antibodies and thyroid hormone levels. Furthermore, the patient's thymic tissues underwent immunohistochemical staining for TSH-R, which demonstrated the presence of thymic TSH-R. The correlation between serum TSH-R antibody levels and thymic hyperplasia sizes and the presence of TSH-R in her thymus suggest that TSH-R antibodies could have a pathogenic role in thymic hyperplasia.


Let G m×n (m ≥ n) be a complex random matrix and W = G m×n H G m×n which is the complex Wishart matrix. Let λ 1 > λ 2 > …>λ n > 0 and σ 1 > σ 2 > …>σ n > 0 denote the eigenvalues of the W and singular values of G m×n, respectively. The 2-norm condition number of G m×n is κ2Gm×n=λ1/λn=σ1/σn. In this paper, the exact distribution of the condition number of the complex Wishart matrices is derived. The distribution is expressed in terms of complex zonal polynomials.


Natural resources are being continuously exploited and suffer degradation due to high human and livestock population density as well as poor management. Total village ecosystem was investigated in Badadhuleswar, a smal1 village ecosystem in Baiyalish Mouza situated in the bank of river Mahanadi of Cuttack district, Odisha, India. Badadhuleswar village has population of 1159 of which 600 are males while 559 are females as per Population Census 2014. Approximately 19% of the men are involved in secondary occupations such as fishing and other agro-based industries. About 75% of the women work: agriculture (33%), labour (37%) and others (5%). The number of land-owning farmers has increased by 76% whereas that of landless labourers has decreased by about 24% over the past 10 years. Paddy is the major crop of Badadhuleswar, currently grown on 128 ha (55% of the total). The crop is primarily rain fed and cultivated during kharif with ponds as an additional source of irrigation.


Electromagnetic shielding has been a well-known mechanism to protect electronic circuits and antennas against unnecessary noise and signals in the system. Thus, this paper has introduced a shielding for very low-frequency subsurface imaging in the form of an antenna enclosure that will help in efficient power transfer and redirection of the signal. With that, the AHP technique was utilized for ranking the sub-criteria and alternatives concerning electrical qualities, material quality features, and manufacturing factors for selecting the best material for an antenna enclosure. The substrate materials which are also referred as alternatives include the Roger 5880 woven glass reinforced hydrocarbon/ceramics, FR4 glass-reinforced epoxy laminate material, and epoxy resin. Furthermore, an AHP calculator was utilized to perform the consistency ratio computations where its value must not be greater than 0.1. Based on the findings, the most suited material for a substrate material is epoxy resin dielectric substrate which considerably satisfies the electrical and mechanical requirements in the dipole plate of an underground imaging antenna. With a 0.373 weight value, it outperformed the Roger 5880 and the FR4 with 0.309 and 0.300 weight values, respectively, in total weight ranking alternatives. This claim was verified technically by performing electrical antenna simulations in Altair Feko on a one-pair equatorial dipole-dipole antenna. The epoxy resin practical reading of 6.354 μA, 7.567 kV/m, 8.580 kV/m, 87.651% 1.020 W of receiver current, inner and outer enclosure electric fields, power efficiency, and power loss, respectively, operated at 3 kHz which is ideal for long wave soil exploration.


OME as sustainable alternative diesel fuel burns without the agglomeration of soot particles which is the case for fossil and paraffinic diesel fuels. Nuclei mode particles are mainly of a volatile nature and do not survive exhaust aftertreatment.


This paper provides a conducive criterion to investigate the stability of unforced continuous-time T-S fuzzy models in case of having second-order state matrices. According to the Tanaka and Sugeno theorem, the stability of a Takagi-Sugeno (T-S) fuzzy model can be proved by finding a common symmetric positive-definite matrix P for all the subsystems satisfying set of Lyapunov inequalities. But in many cases, especially by increasing the number of fuzzy rules, seeking such a common matrix seems to be a daunting task. In this paper, a simple sufficient stability criterion in terms of Lyapunov function candidate is proposed to investigate the global asymptotic stability of continuous-time T-S fuzzy models. In this case, the region of existence for the common positive-definite matrix P is investigated. It will be shown that choosing any arbitrary point from the obtained common region leads to a matrix P which can fulfill the relevant set of Lyapunov inequalities. In other words, finding any common region for such a matrix concludes the asymptotic stability of the system. This approach has the merit of specifying the existence or non-existence of the common matrix P for a fuzzy system. Several examples are given to illustrate the effectiveness of the proposed method.


Melanins are dark pigments, and their production is widespread in the fungal kingdom. The importance of melanins for the survival and longevity of fungal propagules has been recognized for a long time. The pathway of melanin biosynthesis is different among fungal groups (Bell and Wheeler, 1986). Some species of Ascomycotina and related Deuteromycotina produce dark-brown to black melanins from pentaketide via 1, 8-dihydroxynaphthalene (DHN) as the precursor of the polymer. This pathway was first studied in Verticillium dahliae Kleb. using melanin-deficient mutants (Bell et al., 1976). In other plant patho-


The purpose of this dissertation was to explore the state of critical information literacy (CIL) in higher education as it is enacted and understood by academic librarians. This qualitative study investigated the institutional support, nonsupport, and barriers to CIL programs and the effectiveness of experiential critical pedagogy for information literacy (IL) learning as taught and studied by 19 CIL specialists. Purposeful sampling was used to gather a sample of 17 academic librarians and two professors of library and information science who had previously worked as academic librarians. The sample included 11 females and eight males; 18 participants were Caucasian and one was African American. Data were collected through 40-60 minute semi-structured interviews and a brief demographic survey. Experiential education served as the broad theoretical framework for this study, which stems from the tradition of critical theory. This study was guided by the work of two major experiential learning theorists and theories: Paulo Freire and critical pedagogy and Jack Mezirow and transformative learning. Mezirow and Freire focused their work on adult education and grounded their approaches in critical theory and focused on power relationships, reflection, and the emancipatory potential of education. The findings were framed through a lens of Freire's conception of critical pedagogy because it was the major theoretical framework that most of the study participants used to guide their work. Findings suggest that academic librarians who teach CIL do not learn about it in their MLS programs. They tend to use three major critical teaching methods, including student-centered approaches, discussion and dialogue, and problem-posing methods. Participants tended to struggle more with using critical methods than with incorporating critical content. Slightly more than half regularly used critical methods in their teaching, but all participants incorporated critical content, including critical source evaluation and subject headings and language used in information production and dissemination. The findings also suggest that CIL specialists are likely to believe that CIL is best taught within the broader context of academic disciplines and that strong relationships with faculty are crucial for successfully implementing information literacy programs of any kind, including CIL programs. Most participants felt supported by their library administrators and at least minimally by college or university administrators, even though they thought administrators did not have a clear idea of what they do in the classroom. The professional identity and culture of librarians and librarianship played a large role in whether and how librarians were drawn to CIL and in their ability to practice it. The results of this study will allow librarians and educators to make more informed decisions about how to design, teach, and implement programs and will benefit library science scholars and policy makers in terms of knowing how it is being taught and supported at the institutional level.


Materials management practice is a procedurethat coordinates planning, requirement assessment,sourcing, purchasing, transporting, materials storing and controlling, wastage minimisationand cost reduction for profit optimization.Material management have been a great problem to most firms in the construction industrydue to a tendency of mismanagement of materials.The scale of activities concerning materials managementincreases as the size of the contract increase.Thisstudycentered on the impact of materials management practices in the Somaliaconstruction project delivery.The objectives ofthis studyaretoinvestigate the current practice of material management at construction projects, to identify the causes of ineffective material management, and to examine the impact of material management process to the construction project delivery.A questionnaire survey was conducted to collect data from Grade A contractor company in Mogadishu, Somalia and the respondent consist of project managers, civil engineers, architect and site managers. The findings revealed that current practice of material management in construction projects in Somalia include identifying the needed materials, consideration of site layout and location, materialavailableclose to site, material conformwith specifications and material supplied on-time. The studyalsofound thatmost common root causes of ineffective material management were undefined scope, incomplete drawings, inadequate information on material supply, poor scheduling of material on site, nodetermination ofwhat and whenthe material needed and lack indeterminingthe quantity of material needed. Furthermore, the respondents of this research indicated that the occurrence of cost overrun and delay in progress of the work are the major impacts of ineffective material management thatbring negative impact to the construction project delivery in Somalia. The research concludes that effective material management practice can improve the overall handling of material and smooth project delivery on site.Aproper planning of material management practice right from the start of the project execution should be practiced on site in order to ensure timely execution of the project and standard of the work delivery within reasonable cost, time and quality.


VoIP service can provide effective and economic voice conversations for global individuals, companies and enterprises. It also preserves more QoS constraints than many other multimedia network applications. While VoIP is applied in wireless mobile networks, the further challenge is the serious QoS impact from the burst loss of packets during handoff. In this paper, we propose an effective scheme to endeavor to reduce quality degradation in mobile VoIP (MVoIP) service. The proposed P3T scheme+ couples an improved cross-layer pre-registration scheme with our enhanced PPT (predictive packet transmission) scheme not only to reduce handoff latency in layer 3, but also further to recover the lost packets from handoff latency. Besides, we not only validate our proposed scheme via theoretic analysis, but also further apply the E-model to demonstrate the improved objective perceptual voice quality while applying the proposed P3T handoff scheme.


Current approaches to oral assessment of English in English secondary schools tend to concentrate more on 'confidence' and 'participation' than on the quality of children's thinking. This undermines the rich possibilities in classroom talk for cognitive development. Behavioural assessment approaches deny the essentially cognitive character of spoken English. This paper compares two brief representative extracts from a larger data‐set of students engaged in small group debate on the subject of abortion. One group of students are hindered in their discussion by an inability to conceptualize abstractly. It is suggested that a formative assessment approach based on a model of cognitive progression such as Vygotsky's could enable all students to develop as speakers by encouraging their teachers to focus more explicitly on the development of the quality of thinking. A sociocognitive framework for conceptual progression could guide teachers in their interpretation of peer debate in order to develop the quality of students' understanding and argument. Building on the work of Newman, Griffin and Cole, and Torrance and Pryor, further research should be conducted into the ways in which formative teacher–student and student–student assessment dialogue might enhance students' ability to think through talk.


This paper proposed a multi-objective guaranteed feasible connected and autonomous vehicle (CAV) platoon control method for signalized isolated intersections with priorities. Specifically, we prioritized the intersection throughput and traffic efficiency under a pre-defined signal cycle, based on which we minimized fuel consumption and emissions for CAV platoons. Longitudinal safety was also considered as a necessary condition. To handle the aforementioned targets, we firstly designed a vehicular sub-platoon splitting algorithm based on Farkas lemma to accommodate a maximum number of vehicles for each signal green time phase. Secondly, the CAV optimal trajectories control algorithm was designed as a centralized cooperative model predictive control (MPC). Moreover, the optimal control problem was formulated as discrete linear quadratic control problems with constraints with receding predictive horizons, which can be efficiently solved by quadratic programming after reformulation. For rigor, the proofs of the recursive feasibility and asymptotic stability of our proposed predictive control model were provided. For evaluation, the performance of the control algorithm was compared against a non-cooperative distributed CAV control through simulation. It was found that the proposed method can significantly enhance both traffic efficiency and energy efficiency with ensured safety for CAV platoons at urban signalized intersections.


Confusion of the terms open and closed kinetic chain and scarcity of research comparing kinetic chain exercises that have similar mechanics and loading prompted this case study. Exercises were classified by the boundary condition of the distal segment and presence of an external load. Classifications included a fixed boundary condition with an external load (FEL), a movable boundary with an external load (MEL), and a movable boundary with no external load (MNL). It was hypothesized that if the direction and mass of loading in MEL and FEL exercises were similar, the electromyographic activity of the primary muscle groups involved would be comparable. Muscular activity was monitored from six shoulder muscles during one MNL, four MEL, and five FEL exercises. The results indicated that MEL and FEL exercises having similar biomechanics produced comparable muscular activity. Evaluation and selection of exercises for patients should be based upon mechanics and loading that achieve appropriate muscle activity.


improbable under the existing system of caring for and treating the insane that the death-rate will permanently revert to the high percentage of by-gone years; but as regards the admissions, there is less certainty." This is undoubted ; but the tendency is almost invariably upwards, and in county asylums, at least, they would seem to rise in proportion, as wages are high and work plentiful. At any rate the Committee are unquestionably right in adding an additional fifty beds to the accommodation; and it would be most desirable to have a detached block for a like number of private patients, which would bring the total up to about 1,100 beds, beyond which it should under no circumstances be allowed to go. The Committee, " express their appreciation of the able manner in which, during the past, as in previous years, the Medical Superintendent has discharged the duties attached to his office." The weekly cost per head was 9s. 8?d. Private patients pay from 15s. to 21s. EAST RIDING ASYLUM, BEVERLEY.


Abstract This article introduces a fairly young transmitter and receiver concept using Telecom COTS building blocks consisting of high performance Digital-Analog-Converters (DAC) and Analog-Digital-Converters (ADC) in conjunction with Digital Upconverters (DUG) and Programmable Downconverters (PDC) eliminating many sources of error compared to the conventional analogue counterpart. An overview of some popular integrated circuits investigated is given and a concept for a replacement of conventional receivers for a FGAN-FHR experimental system is shown. First experiences concerning direct digital IF synthesis and digital IF demodulation with respect to Spurious Free Dynamic Range (SFDR) and channel equality are brought together as well as limits of parts commercially available. Performance with respect to adaptive beamforming and jammer cancellation for multichannel radar systems is discussed.


OBJECTIVE
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of complete or partial obstruction of the upper airway leading to episodic desaturation. OSA patients often show symptoms of anxiety. Our study aimed to examine the presence and levels of anxiety in OSA and simple snoring relative to control subjects and to investigate the correlation between anxiety scores and polysomnographic, demographic, and sleepiness parameters.

SUBJECTS AND METHODS
The study included 80 OSA, 30 simple snoring, and 98 control cases. Demographic, anxiety, and sleepiness data of all subjects were acquired. The Beck Anxiety Inventory (BAI) was used to determine the level of anxiety. The Epworth Sleepiness Scale (ESS) was used to evaluate the sleepiness level of participants. In addition, polysomnography recordings of those in the OSA and the simple snoring group were acquired.

RESULTS
Significantly higher anxiety scores were found in patients with obstructive sleep apnea and simple snoring compared to the control group (p<0.01, p<0.01, respectively). From the polysomnographic data obtained from OSA and simple snoring subjects, the CT90 values (cumulative percentage of the time spent at saturations below 90%) and the AHI showed a weak positive correlation between the level of anxiety (p=0.004, r=0.271; p=0.04, r=0.196, respectively).

CONCLUSIONS
Our study concluded that polysomnographic data showing the depth and duration of hypoxia may be more reliable in showing neuropsychological disorder and hypoxia-related comorbidities in OSA. The CT90 value can be used as a measure in the assessment of anxiety in OSA. Its advantage is that it can be measured with overnight pulse oximetry along with in-laboratory PSG and HSAT (home sleep apnea test).


With the fast development of multimedia technology, efficient management of multimedia data has become more and more important. In this paper, a multimedia database is established. It uses hypermedia and object-oriented technology. Besides that, to realize intelligent retrieval such as semantic retrieval, the authors have added a simple expert system. This can manage multimedia information such as sounds, images, texts and videos efficiently.


This paper describes the rst participation of the SINAI (Intelligent Systems of Access Information) group of the University of Jaén in the AVE task of QA@CLEF 2007. We have developed a system made up of training and classi cation processes, that uses machine learning methods (bbr, timbl). Based on lexical features it obtains good results, a 41% of QA accuracy.


The growth and characterization, including band structure and gain calculations, of strain engineered (Si)GeSn/GeSn heterostructures with large Sn content are presented and discussed in the view of the realization of a direct band gap semiconductor.


The Republic of China first year, the administrative style and achievements of local officials ruin realistic condition and to county magistrate in place government vital role understanding, urges the Beijing government to decide through the test to select the government official, this article elaborates the implementation which the Hubei county magistrate experiments and avoids the native place system, hopes to our country official takes a test now the system and the administrative official chooses a person for a job the system to have the enlightenment.


In this article, we present an application of the optomechanical cavities for absolute rotation detection. Two optomechanical cavities, one in each arm, are placed in a Michelson interferometer. The interferometer is placed on a rotating table and is moved with a uniform velocity of y ¯ ˙ with respect to the rotating table. The Coriolis force acting on the interferometer changes the length of the optomechanical cavity in one arm, while the length of the optomechanical cavity in the other arm is not changed. The phase shift corresponding to the change in the optomechanical cavity length is measured at the interferometer output to estimate the angular velocity of the absolute rotation. An analytic expression for the minimum detectable rotation rate corresponding to the standard quantum limit of measurable Coriolis force in the interferometer is derived. Squeezing technique is discussed to improve the rotation detection sensitivity by a factor of γ m / ω m at 0 K temperature, where γ m and ω m are the damping rate and angular frequency of the mechanical oscillator. The temperature dependence of the rotation detection sensitivity is studied.


Students as prospective teachers have unique characteristics, they are required not only to understand the materials, but also to be able to teach the materials to others when they practice to be teachers, or become actual teachers. This study aims to determine and analyze the pedagogical content knowledge of prospective economic teacher. The population on this research was students who attended micro teaching course. The sample was drawn by using purposive sampling approach. Data were collected in observation sheets, consist of materials mastery, the ability in giving apperception and motivation, selection of methods or learning strategies, selection of media and sources, the ability to performance assessment and the ability to involve learner in learning process. The result of research show that in general, the pedagogical content knowledge of teacher candidates is still in the 'sufficient' and 'good' category; thus, it needs a lot of improvement.


Most organizations regard Sustainable Development (SD) as important and within a tridimensional approach (including economic, social and environmental dimensions) SD comprises a range of complex issues. However, traditional management approaches do not capture the variabilities as organizations are complex adaptive systems embedded in a complex adaptive context. Consequently, there must be a fundamental shift towards a complexity theory approach (eg. Complex Adaptive Systems, CAS). When SD is viewed from a CAS approach it becomes a continuous process of coevolution within a rapidly changing context rather than a once off project. Leaders, managers and practitioners work in this complex and rapidly shifting world need crucial skills such as reflection. This paper proposes a framework combining SD, CAS and reflection. Although a framework does not guarantee success it provides a tool to identify SD, CAS and reflection dimensions, develop an integrated approach, create goals, monitor and evaluate outcomes. Lastly, the paper includes management and research implications.


Based on the vertical compressive static load test and pile mechanics test of three large diameter bored piles (one of the test piles was treated with postgrouting) in granite gneisses foundation, the bearing capacity, deformation characteristics, and influencing factors of the single pile under the limit state are analyzed and compared with the recommended values of survey report and the recommended values of current codes. By comparing the measured and theoretical values of pile axial force, the bearing capacity of cast-in-place pile under normal and limit conditions is analyzed. The experimental results show that the Q-s curve of large-diameter rock-socketed mud wall retaining bored pile with a length-diameter ratio of 25–33 and rock-socketed depth of 5–8 d shows a rapid growth. After grouting treatment, the ultimate compressive bearing capacity of single pile is improved, the maximum settlement is reduced by 6.6%, the rebound rate is reduced by 11.1%, and the settlement effect of controlling pile top is not significant. The bearing capacity and deformation characteristics of the three test piles are less affected by length-diameter ratio and rock-socketed depth. For postgrouting piles, the ratio of frictional resistance of rock-socketed segment and the ratio of pile lateral resistance are less affected by length-diameter ratio and rock-socketed depth, while, for postgrouting piles, the ratio of pile lateral resistance is more affected by rock-socketed depth. The pile end resistance ratio of the three test piles is significantly affected by the rock-socketed depth, whether or not the pile side postgrouting treatment is carried out.


Scaling web applications by adding processors is important as the number of users increase by the day, database size is on the rise which results in huge volume of work. The complication that exists in scaling does not just depend on increasing the count of new processors as the paradox also exists in extensive scaling of Java applications. This limitation is bounded specifically to Java programming language and not to Java platform as a whole. We explore the Object oriented functional languages such as Scala, Clojure and Groovy in Java platform. The peripheral languages take advantage on the infinite scalability of Java platform. The interoperability of Scala, Clojure and Groovy is an asset in Java platform as they run parallel with other Java applications. Additionally, we discuss on how the elasticity and adaptability of the Object Oriented functional languages allows simple and efficient execution in Java platform.


In this paper we discuss the applicability of the agent control language GoLog for the representation of plans to handle the response to homeland security incidents. Our goal is a representation for plans that is high-level and flexible. The specific actions executed when the plan is interpreted should be selected through logical inferencing to be the appropriate actions under current circumstances. Our approach is illustrated with an example of agricultural bio-terrorism. Introduction and Motivation After a homeland security incident has occurred (no matter of what type), the speed of the response is of utmost importance. The amount of detail that human analysts must take into account is immense. We propose the specification of high-level plans to be executed automatically by agents/programs to relieve some of the responsibilities from human analysts. The hope is that the execution of these plans which incorporate both common-sense and specialized background knowledge will exhibit some of the flexibility of human responders. Our goal is a language that allows the specification of relatively abstract high-level plans. When the plans are evaluated (i.e. interpreted by an agent) the specific actions to be executed are selected through logical inferencing given the background knowledge. For example, the response to an act of bio-terrorism can be specified in general terms, but the specifics depend upon the particular biological agent suspected and the specifics of the location. First we briefly describe the GoLog language and its variants. Our plan specification language is being built upon GoLog. Next an illustrative bio-terrorism example is described. Finally, current and future work is discussed.


This note examines how an iconic Arabic phrase such as the basmala has been translated into Persian and English. These translations reflect different aesthetic, political and cultural aspects of this phrase. Outside of its Qur' ā nic context, embedded within it, the basmala has extended cultural meanings. An equivalence-based approach to the translation of formulaic expressions would not suffice for the translation of the basmala in literary contexts.


Electric power generation by means of photovoltaics (PVs) has seen an explosive growth worldwide over the past decade. This growth is driven in part by a global concern about climate change, the adoption of renewable portfolio standards, government rebates and tax incentives, and reduction in PV system cost. This article presents the basic theory on how a silicon-based PV cell converts sunlight into electricity. Silicon material and sunlight properties are reviewed with emphasis on the amount of energy that is needed to free valence electrons (i.e., bandgap) and energy content of sunlight throughout the solar spectrum. The need to add impurities to form n-type and p-type materials, for the purpose of separating the free electrons from the holes left behind, is clearly addressed. The electrical characteristics of a p–n junction solar cell are described in terms of drift and diffusion currents and the strength of the electric field that appears across the depletion region. Owing to their similarities, the equivalent circuit model of the cell when exposed to sunlight is derived from that of a p–n junction diode. The impact of changes in the numerous variables that appear in the circuit model, on the cell current–voltage (I–V) curve and power conversion efficiency, are reviewed, along with the building blocks that make up a solar PV module.

Keywords:

solar spectrum;
semiconductor materials;
doping;
diode circuit model;
cell efficiency


Pattern recognition or artificial neural network with chemical bond parameters as features or inputs is applied to MeX-REX3 type phase diagrams investigation. After training with the data of known phase diagrams,the mathematical models obtained can be used to make computerized prediction of the formability,the chemical stoichiometry, the melting types(congruent or incongruent melting) and melting point of intermediate compounds,with good results.


PE culture composes the main part in campus cul ture. It can improve th e implement of quality education, and make students behave in good manners and l ead a healthy life. It can also foster students' individuality and spirits of c ompetition, innovation, collectivism as well as patriotism.


Thank you very much for downloading directory of services for refugees and immigrants. Maybe you have knowledge that, people have look numerous times for their favorite books like this directory of services for refugees and immigrants, but end up in harmful downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they are facing with some harmful bugs inside their computer.


As cities become increasingly complex, Information and Communication Technologies (ICTs) bring smartness into organisations and communities, contributing to a more competitive tourism destination, i.e., smart tourism destinations. Enhanced information access coupled with a new kind of tourists avid for online content and predisposed to share information on social media, allows for a better understanding of tourist behaviour regarding their spatial distribution in urban destinations. Thus, smart tourism portrays individuals as information makers, refining the available alternatives for tracking their location. Big data analytics is a technology with the potential to develop Smart City services. From the analysis of the spatial distribution of tourists in the city of Lisbon based on data collected from the 'Panoramio' social network, we identify the most popular places in the city in a context of tourist visits. This new data largely contributes to understanding the consumption of space within urban tourist destinations and therefore enables us to differentiate the overcrowded places from the ones with potential to grow. This allows decision-makers to imagine new ways of planning and managing towards a sustainable 'smart' future.


India's Foreign Exchange Reserves have increased from US $9.220 billion (1991-92) to US $ 341.638 billion at the end of March 2015 as a result of measures introduced to liberalize the economy and the financial sector reforms in 1991. This research explores various definitions provided by researchers on the Reserve Adequacy and then attempts to find adequate level of Forex. for India . The management of excess Reserves built up for so many years is the biggest challenge for the country. Currently in India, RBI in consultation with the GOI manages the Foreign Exchange Reserves. Emphasizing on the objectives of Reserve management as liquidity and safety, this paper attempts to look at various options to utilize the excess reserves. In this paper, quantitative techniques have been used to measure the impact of various independent variables like Net Export, Foreign Direct Investment, Foreign Institutional Investment and Non Resident Deposits and their impacts on Foreign Exchange Reserves are interpreted. Thereafter, the paper looks at various practices of investing Reserves on income generating assets in emerging economies. Then, the paper recommends methods of appropriate management of reserves both for precautionary and investment purposes.


This paper generalizes the Blanchard-Fischer model (1989) for a small open economy with installation costs of investment. By allowing the divergence of the subjective time preference rate and the world interest rate, the model avoids a constant consumption path which is neither feasible nor desirable for a small growing economy. While the divergence does not define an usual steady state equilibrium, the installation costs of investment lead the economy to the point at which foreign borrowing is entirely used for the consumption purpose while avoiding infinite borrowing. The intrinsic dynamic responses of the model to an unexpected world interest rate shock is then analyzed. [F34]


The maximum entropy method (MEM) and Gaussian process (GP) regression, which are both well-suited for the treatment of inverse problems, are used to reconstruct net-baryon number distributions based on a finite number of cumulants of the distribution. Baryon number distributions across the chiral phase transition are reconstructed. It is deduced that with the increase of the order of cumulants, distribution in the long tails, i.e., far away from the central number, would become increasingly important. We also reconstruct the distribution function based on the experimentally measured cumulants at the collision energy GeV. Given the sizable error of the fourth-order cumulant measured in the experiments, the calculation of MEM shows that with the increasing fourth-order cumulant, there is another peak in the distribution function developed in the region of the large baryon number. This unnaturalness observed in the reconstructed distribution function could in turn be used to constrain the cumulants measured in the experiments.


In swarm control, many robots coordinate their actions in a distributed and decentralized way. We propose a consensus-based control barrier function (CCBF) for a swarm. CCBF restricts the states of the whole distributed system, not just those of the individual robots. The barrier function is approximated by a consensus filter. We prove that CCBF constrains the control inputs for holding the forward invariance of the safety set. Moreover, we applied CCBF to a practical problem and conducted an experiment with actual robots. The results showed that CCBF restricted the states of multiple robots to the safety set. To the best of our knowledge, this is the first CBF that can restrict the state of the whole distributed system with only local communication. CCBF has various applications such as monitoring with a swarm and maintaining the network between a swarm and a base station.


This paper explained falia 'taboo' in kaghati in the Muna Speech Community (MSC) from the ecolinguistic perspective. The kite 'kaghati' is one type of the traditional games and a tribal cultural product in MSC which still exists and remains maintained. The forms of interaction, interrelation, and the interdependence in MSC with the natural and socio-cultural environments are recorded in falia's ke-kaghati-an.The problem in this paper is to answer the question what expression in falia's ke-kaghati-an is used to express environment in MSC. The purpose of this paper is to describe and analyze the falia expressions found in ke-kaghati-an's environment. This research is classified as a qualitative descriptive study as it describes the phenomena of falia expressions and environmental knowledge, especially the ones currently used in ke-kaghati-an's environment, and the source of natural data as a manifestation of the Muna's socio-cultural-ecological life.
 Falia's ke-kaghati-an is such a magical expression of magical value that MSC, especially the kaghati maker, feels afraid of breaking it.The expression of falia's ke-kaghati-an teaches the belief in God, gratitude, balance of life, discipline, justice, honesty, orderliness, beauty, tolerance, and mutual respect. Falia is one way in which MSC shows their adherence to the local wisdom values, especially with regard to the environmental conservation that has been inherited from the ancestors since a long time ago. Conservation of the wealth of the expression of falia in MSC is very important, for both the sustainability of the Muna language and the conservation of kaghati with its traditions and culture, which is preserved in the meaning and cultural values ??of the past heritage as part of itspersonal identity, especially for the younger generation.


OBJECTIVE: To study the photostability of the levofloxacin hydrochloride injection. METHODS: The content of levofloxacin hydrochloride was determined and its UV spectra changes were observed after being lighted by three different light sources-the UV light, the sunlight and the natural light for different periods of time. Whether there is any decomposed product or not was determined by TLC. RESULTS: There were decompositions of levofloxacin hydrochloride injection subjected to illumination from three light resources, with that under the sunlight decomposed faster; Rf value under TLC of the decomposed product was found to be 0.72. CONCLUSION: Levofloxacin hydrochloride injection should be kept away from UV light, the sunlight and the natural light.


This study was an attempt to investigate the effect of using podcasting as a revision tool in the recall of English vocabulary items after the teaching program and prior to the examination among Iranian EFL learners. It applied a quasi experimental approach to determine whether the students who were exposed to podcasting were better in recalling the learning material or not. For this purpose, 68 EFL learners were selected from an English teaching institute in Iran as participants. They were divided into two groups. The first group was exposed to the vocabulary items as presented in their textbooks by means of their conventional teacher student classroom settings, textbooks and hand written notes. The second group received the same material as audio recordings on podcasts. At the end of the semester (after 2 months), both groups were examined by the same multiple-choice test to assess their performance on the material. The results confirmed the positive effect of using podcasts as a revision tool in learning English vocabulary and better recalling of the words.


Summary: The btest concepts of the genetics of i oLlted yndactyly :m.' described in relation to a case in which the malformation could be traced back to four generations. The different principles of classification of syndactyly and the therapeutic po ibilities arc discussed, call ing special :'lttention to early operation in in fants. Eck


One-step size-controlled synthesis of ZnSe quantum dots is
studied and the obtained QDs are luminescent with the emission wavelength
varying over a wide range (up to 100 nm) depending on the particle size;
the single-molecular precursor is an air-stable bis(phenylselenolato)zinc
N,N,N′,N′-tetramethylethylenediamine (TMEDA)
complex, which effectively affords different sizes of ZnSe QDs depending on
growth temperatures.


Abstract:

This study compares the customers satisfaction between two largest online shopping site Jingdong and taobao. Jing Dong (JD) is China's biggest online direct retailer by net stock volume. JD has the biggest satisfaction framework of any internet business organization in China. on the other hand Taobao is a Chinese web based shopping site like eBay, Amazon and Rakuten, which is worked in Hangzhou, Zhejiang by Alibaba Group. This study analyzed the customer satisfaction between two largest online shopping site jd and taobao. JD is popular for quality of product and taobao is popular for discount. JD Jing Dong is China's biggest online direct retailer by net stock volume. JD has the biggest satisfaction framework of any internet business organization in China and Taobao is a Chinese web based shopping site like eBay, Amazon and Rakuten, which is worked in Hangzhou, Zhejiang by Alibaba Group.

 Key words: Online shopping, Customer satisfaction, Comparison, Jingdong and Taobao


A large number of papers have examined various aspects concerning the volatility of the public real estate sector. Whilst this literature initially tended to concentrate on the volatility dynamics of single-domestic markets (e.g. Stevenson, 2002; Cotter & Stevenson, 2006, 2008; Liow, 2009; Liow & Ibrahim, 2010) it has increasingly examined the international issues. This strand of research is also tied in with those papers to have considered spillovers and contagion affects in returns (Michayluk et al., 2006; Liow et al., 2011; Hoesli & Reka 2011; Yang et al., 2012; Zhou 2011). Two recent papers (Liow, 2012, Stevenson, 2013), in turn extend this literature to consider the drivers of integration across international securitised real estate markets. This study further extends the above cited pieces of research to more fully account for the impact of exchange rates. It analyses the volatility transmission between the public real estate and foreign exchange markets. This is undertaken using a trivariate specification of the Baba, Engle, Kraft and Kroner-generalised autoregressive conditional heteroscedasticity (BEKK-GARCH) model. The analysis extends from 1990 through 2014 and the results highlight the importance of factoring in fully the currency markets into any analysis of international investment.


Background: Individuals with clinically ascertained monoclonal B-cell lymphocytosis (c-MBL) having the phenotype of the chronic lymphocytic leukemia (CLL) have a 1-4% per year risk of progression to CLL requiring therapy. The risk factors for progression and the outcomes of individuals with c-MBL are not well defined. Methods: Using the Mayo Clinic CLL Database, we identified individuals with c-MBL (absolute B-cell count of Results: Eight hundred and fifty-one individuals with c-MBL were identified and included in this analysis. Median age was 69 years (range, 38-95 years), and 527 (62%) were males. The median absolute B-cell count at the time of diagnosis was 2.6 x 109/L (range, 0.1-5.0 x 109/L). The median serum beta-2 microglobulin (β2M) was 2.2 mg/dL (range, 1.0 - 21.5 mg/dL). One hundred and nine (30%) individuals had unmutated IGHV genes, and 38 (7%) had high-risk FISH (defined as either del17p13 or del11q23). The CD38 (≥30%), ZAP-70 (≥20%), and CD49d (≥30%) status was positive in 19%, 23% and 34% individuals, respectively. After a median follow-up of 6.8 years, 99 individuals required therapy for progressive disease (at a rate of 2.1% per year, Figure 1). On multivariable analysis, the following factors were associated with a higher risk of progression to CLL requiring therapy: a) unmutated IGHV status (hazard ratio [HR]:3.8, 95%CI 2.1 - 7.0, p The median OS of individuals with c-MBL was 11.8 years. Although the OS among individuals with c-MBL and the age- and sex-matched general population of Minnesota appeared similar for the first 10 years of follow-up, OS was significantly shorter in the c-MBL group during the full follow-up interval (p=0.004, Figure 3). Conclusion: In this large cohort of individuals with clinically ascertained MBL, the risk of progression to CLL requiring therapy was 2.1% per year. Biological characteristics of the B-cell clone including IGHV mutation status, and CD49d and CD38 status predicted time to first CLL therapy. On extended follow-up, the OS of individuals with c-MBL was significantly shorter relative to age- and sex-matched general population. These findings have important implications for counselling individuals with clinically ascertained MBL. Disclosures Parikh:Pharmacyclics: Honoraria, Research Funding. Ding:Merck: Research Funding. Kenderian:Novartis: Patents & Royalties, Research Funding. Shanafelt:Pharmacyclics: Research Funding; GlaxoSmithkKine: Research Funding; Janssen: Research Funding; Genentech: Research Funding; Celgene: Research Funding; Cephalon: Research Funding; Hospira: Research Funding.


This passage, part of the kriyat shema prayer complex, is recited twice daily by observant Jews who till this day can be seen with fringes tsitsit dangling from their prayer shawls. The eleventh century Biblical commentator, Rashi, explains how looking at the fringes reminds one of all God's commandments. The word tsitsit fringes is numerically equivalent to 600. Tsitsit are traditionally tied with eight strings and five knots for a total of 613 the number of commandments in the Torah. Linguistically, however, the subject of the sentence that which is to remind us of God's commandments is not the tsitsit, but rather the thread of blue, the tekhelet.


Abstract The sea ice simulations by the Intergovernmental Panel on Climate Change Fourth Assessment Report (IPCC AR4) models for the climate of the twentieth century and for global warming scenarios have been synthesized. A large number of model simulations realistically captured the climatological annual mean, seasonal cycle, and temporal trends of sea ice area over the Northern Hemisphere during 1979–99, although there is considerable scatter among the models. In particular, multimodel ensemble means show promising estimates very close to observations for the late twentieth century. Model projections for the twenty-first century demonstrate the largest sea ice area decreases generally in the Special Report on Emission Scenarios (SRES) A1B and A2 scenarios compared with the B1 scenario, indicating large multimodel ensemble mean reductions of −3.54 ± 1.66 × 105 km2 decade−1 in A1B, −4.08 ± 1.33 × 105 km2 decade−1 in A2, and −2.22 ± 1.11 × 105 km2 decade−1 in B1. The corresponding percentage reductions are...


In this paper we discuss cubic B-spline collocation method. We have given the derivation of the B-spline method in general. We have applied the method for solving one-dimensional heat equation and the numerical result have been compared with the exact solution.


Thank you for downloading putting voip to work softswitch network design and testing. Maybe you have knowledge that, people have look hundreds times for their chosen readings like this putting voip to work softswitch network design and testing, but end up in harmful downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they cope with some harmful virus inside their laptop.


Facing an audience with unpredictable interests, Plautine statements are in charge of producing a spectatorial attachment of the actio with rhetoric operations aimed to capture and maintain the attention of the audience. Thus, the interaction scaena / cavea is sustained by linguistic, pragmatic and compositional devices from the fabulae. The play Stichus is a paradigm of such procedures, displayed in a fictionis dispositio apparently anomalous. From a performatic perspective, that presumed abnormality could be analyzed as a deliberate procedure that deals with the discontinuity of the audience's attention and proposes a scenic enunciation adapted to its aesthetic consumption.


A scheme is introduced to quantitatively analyze the magnetically induced molecular current density vector field $\mathbf{J}$. After determining the set of zero points of $\mathbf{J}$, which is called its {\em stagnation graph} (SG), the line integrals $\Phi_{\ell_i}=-\frac{1}{\mu_0} \int_{\ell_i} \mathbf{B}_\mathrm{ind}\cdot\mathrm{d}\mathbf{l}$ along all edges $\ell_i$ of the connected subset of the SG are determined. The edges $\ell_i$ are oriented such that all $\Phi_{\ell_i}$ are non-negative and they are weighted with $\Phi_{\ell_i}$. An oriented flux-weighted (current density) stagnation graph (OFW-SG) is obtained. Since $\mathbf{J}$ is in the exact theoretical limit divergence free and due to the topological characteristics of such vector fields the flux of all separate vortices and neighbouring vortex combinations can be determined by adding the weights of cyclic subsets of edges of the OFW-SG. The procedure is exemplified by the case of LiH for a perpendicular and weak homogeneous external magnetic field $\mathbf{B}$}


The flow establishment processes and the duration of the test time in low and high enthalpy impulse facilities have been investigated by using high speed flow imaging and time-resolved surface sensors. For the low enthalpy facility, the high speed imaging gave sufficient information to fully characterise the steady flow time including a measurement of the flow Mach number. Results for tests on a higher speed super-orbital expansion tube showed that imaging of the shock stand-off on a blunt body gives a good indication of the duration of the flow establishment processes. However, static pressure measurements provide a better indication of the end of the test time defined by the arrival of the leading edge of the unsteady expansion generated by diaphragm rupture.


rituals of the Penampang Kadazan of Sabah. The monogit ritual is one of traditional
Taqwim rice rituals. It is usually done for two or three years at a time or when someone
in the community is ill or distressed. The ritual is implemented to ensure that the house
spirit guardian (miontong) is at peace to make sure that everything will be as normal as
usual. This ritual takes about four days and three nights administered by female traditional
healers known as bobohizan headed by Bohungkitas.
The gandang beat which leads the gong music known as sompogogungan (consisting
of six gongs) together with the sumazau dance becomes part of the ceremony. The
combination of the gandang beat with sompogogungan is believed to connect humans
with the supernatural world. It is done by the bobohizan while reciting the mantra (inait)
as the bobohizan's escort to the supernatural world to meet, surprise and provoke the evil
spirit to ask them to return the imprisoned human spirit. A dish known as pamanta is
provided in the stage by stage performance according to pason (message/to inform),
matang (awakening of the spirit), tumingak (provoking of the spirit), sayak (calling of the
imprisoned spirit), mihung (calling to come closer), and sumonson (inviting to enjoy the
dish).
The pamanta gift is also done according to the process and certain sequence while
the bobohizan does specific movements of the sumazau dance such as magampa (collection
of illnesses), mundang (entertainment preparation), pasasazau do miontong (food serving),
hoputan (return of the spirit) and monoinig (collection of imprisoned spirits). At certain
times, the bobohizan who is under the appearance of sumazau is in a trance or has been
possessed by miontong (nosuang) when her body moves strongly, full of energy and
unusual. At this time, all the good and evil spirits are believed to be being entertained by
the miontong which is the highlight of the ritual.
Thus, the gandang beat from sompogogungan and the sumazau dance that have
become important tools in the monogit ritual do not only combine elements of the Kadazan
Penampang community's traditional performing arts in the healing ritual but empower
performing arts as a ritual tool. The dependence of healing ritual such as monogit to the
presence of a traditional healer (bobohizan and bohungkitas), dish (pamanta), gandang
beat, sompogogungan music and sumazau dance, very clearly empowers the ritual and
traditional performing arts.


A Elektroadhasionsgreifer (20) for holding workpieces (31) comprising a first spiral-shaped electrode (1) having a plurality of turns and a second spiral electrode (2) having a plurality of turns, the two spiral shaped electrodes (1, 2) disposed at least partially bifilar are characterized in that the Elektroadhasionsgreifer (20) comprises a diode element (6), through which the spiral electrode (1, 2) connected together, with all of the above the diode element (6) connected in series parts of the two spiral electrodes (1, 2) has a non-zero inductance. The invention provides a Elektroadhasionsgreifer where easily a review of the gripper assignment is possible.


ICT competence is an integral characteristic, and evaluates the results of bachelors of pedagogical universities. This article describes the tasks, the purpose of which is to simulate the future activity of students using various software tools and evaluation criteria, developed a test to detect the levels of motivation and the ability to educate themselves in this area. Complex evaluation of these components will identify the level of ICT competence of future teachers and allow to make the necessary changes to the content of training.


Reality and its Shadow, a brief yet powerful essay written in 1948, is the only text where Emmanuel Levinas (1906-1995) deals solely with the ontology of art. Already in this early text, we can see how his understanding that ethics is the ground of philosophy drives his discussion. The nature of art is therefore treated in relation to what it does, ethically, to the subject, the maker, and the viewer. Art is the "inhumanity" and "inversion" of ethics. Only philosophical criticism reintegrates its "inhumanity" in the ethical relation. The strength of Levinas's philosophy issues from a pre-cognitive commitment to the "other", epitomised in the "face to face" relation. Any philosophy emphasising the primacy of the subject over and above the "other" crumbles under his reading. Yet this same strength implies that those domains where the "face to face" relation is obscured lead to irresponsibility. One such domain is art. In this essay I argue that by applying his mature work to the criticism he advances in Reality and its Shadow we can find ethical value in art in virtue of its "inhumanity" and "inversion". That is, we can agree with Levinas that art leads to irresponsibility, and yet ascribe to it positive ethical value in Levinas's own terms. This can help concretise the tension between the ethical and unethical aspects of art within a Levinasian framework.


Purpose: The purpose of this study was to redefine a competency model for each rank of a university's staff and to assess the training needs of each competency in the Digital Transformation era.
Methods: To redefine a competency model, a six-step procedure was designed using a modified generic model overlay method developed by Dubois(1993). A literature review and extant interviews were executed to design roles, responsibilities, and competency structures of each rank. Research team workshops and expert workshops were also conducted to derive a competency model draft which included competency definitions and behavior indicators. Following this, the Delphi method was conducted to secure the validity of the derived model. To assess training needs for university staff, each rank's competencies and common competencies were utilized.
Results: As a result, twenty-five competencies by rank and five common competencies were confirmed. Five common competencies were problem solving, communication, digital literacy, business planning,and documentation. With the assessment of training needs, the highest competencies for each rank were derived. The derived competencies are as follows from the highest rank to common competency:Strategic thinking, vision suggestion/organizational management/conflict and management/creative thinking/responsibility/problem solving.
Conclusion: In order to increase the work efficiency and the competitiveness of university staff,universities need to reform their job structure based on the competencies and should implement talent transformation for the Digital Transformation era.


For the calculations of water-involved systems, such as safety analysis of light water reactors, it is essential to provide accurate water properties. The International Association for the Properties of Water and Steam is an international non-profit association of national organizations concerned with the properties of water and steam. It provides internationally accepted formulations of water/steam properties for scientific and industrial applications. The purpose of this work is to provide a stand-alone software package in C++ programming language to provide accurate and efficient water/steam properties evaluation, based on the latest IAPWS releases. The discussion on related IAPWS releases, code implementations and verifications are provided in details.


This research aims to explore (1) the untruth friendship of Winnie-the-Pooh and (2) its advice for solving starvation of human being in Milne's Winnie-the-Pooh. The research is a descriptive qualitative method with the support of semiotic approach. It uses smoke-fire concept in Pierce's Index to look after Aristotle's 8 characteristics of friendship. Those are explored through Winnie-the-Pooh novel as a primary data and Nicomachean Ethics, book of sociology, and dictionaries as a secondary data. The research discover the untruth is over 4 acts of characters. It keeps some friendship characteristics within. Therefore, those 4 acts directs a man to get a help of a friend.


The effect of magnetic fields on localized corrosion was explored for one-dimensional artificial pits that are used to simulate pitting corrosion, and for two-dimensional pits in thin metal films. It was found that the pitting dissolution of ferromagnetic electrodes was significantly affected by the presence of a magnetic field. The presence of magnetic fields can lead to local stirring in the vicinity of artificial pits in ferromagnetic metals (iron, cobalt, or nickel) and pits in FeCo thin films, through the effects of the high field gradient force and the Lorentz force, causing an increase in the diffusion-limited current when the field is applied parallel to the dissolving surface. When the field is applied perpendicular to the dissolving surface, the field gradient force draws paramagnetic corrosion products toward the metal surface, protecting the metal from dissolution. The field gradient is, however, absent for paramagnetic stainless steel artificial pits, and the Lorentz force itself (in a field of 0.35 T) is insufficient to cause stirring within the pit cavities. Fields that are changing show a considerably bigger effect than static fields.


Broadband cyan‐emitting phosphors are crucial to close the cyan gap of phosphor‐converted white light‐emitting diodes (pc‐WLEDs) for full‐spectrum illumination. In this work, efficient cyan‐emitting Eu2+‐activated phosphor is achieved through structural modulation, which exhibits anti‐thermal quenching behavior. Redshift from blue (469 nm) to cyan (500 nm) emission and enhancement of emission is achieved by codoping Mg2+ and Ge4+ into Eu2+‐activated Na‐beta‐alumina phosphor. The introduction of Mg2+ ions dominates the redshift, while Ge4+ dominates the enhancement of emission. Furthermore, the introduction of Mg2+ and Ge4+ reduces the content of deep trap levels related to VNa defect, which decreases the degree of anti‐thermal quenching and results in better thermal stability. The prototype pc‐WLED by using the cyan‐emitting phosphor exhibits higher color‐rendering index and potential to close the cyan gap of pc‐WLEDs for full‐spectrum illumination. This work presents a paradigm for exploring phosphors with highly efficient and thermally stable emissions.


The purpose of this study was to make valuable suggestions for improving environmental education(EE) teaching materials. For the purpose of this study, we analyzed four secondary school EE textbooks in the perspective of environmental literacy components. The findings of this study are as follows: (1) As a whole, the EE textbooks tend to focus the understanding environmental knowledge much more than environmental activities. (2) In 'main text' domain of EE textbooks, environmental information, including environmental issue knowledge, is much more focused than environmental attitudes and behavior, including socio- political and environmental issue knowledge. (3) In 'graphic data' domain, environmental information about environmental issue knowledge was most prevalent. (4) Most learning activities focus on 'issue skill' component, rather than 'attitude' and 'action' component. (5) The objectives of EE in the 7th national Curriculum were not explicitly embedded in textbooks and too much is inclined toward 'knowledge' and 'skill'. Accordingly, it is necessary to develop 'module-type' EE textbooks to enable integrative EE. Also, it is suggested to develop specific strategies for linking environmental knowledge and attitude/behavior.


Goniothalamus wyanaadensis, Bedd. (Annonaceae) is a small sized tree found in the Wyanaad regions of Western Ghats, Kerala, India at a height of 2000-2500 ft. There are no phytochemical or pharmacological works reported on this plant till date. Goniothalamus species are rich in bioactive lactones and acetogenins. From the title plant we have isolated and identified seven compounds which include a sterol, four lactones namely goniothalamin, althoughlactone, goniopypyrone and 8-acetoxygoniofufurone, an acetogenin squamocin and a phenanthrene lactam, aristolactam B11. Single crystal structure of 8-acetoxy goniofufurone is reported for the first time.


In this paper we adopt Adaptive Lasso techniques in vector Multiplicative Error Models (vMEM), and we show that they provide asymptotic consistency in variable selection and the same efficiency as if the set of true predictors were known in advance (oracle property). A Monte Carlo exercise demonstrates the good performance of this approach and an empirical application shows its effectiveness in studying the network of volatility spillovers among European financial indices, during and after the sovereign debt crisis. We conclude demonstrating the superior volatility forecast ability of Adaptive Lasso techniques also when a common trend is removed prior to multivariate volatility spillover analysis.


The present technique relates to: a semiconductor device wherein the generation of a residual carrier within an organic film is able to be suppressed; a solid-state imaging device; an electronic device; and a method for manufacturing a semiconductor device. This semiconductor device is provided with a first electrode, a second electrode and an organic film that is arranged between the first electrode and the second electrode. At least one of the first electrode and the second electrode is discontinuous; and an inter-electrode region, which is a region sandwiched by the first electrode and the second electrode, and a non-inter-electrode region, which is a region that is not sandwiched by the first electrode and the second electrode, are present within the organic film. The non-inter-electrode region is arranged between adjacent inter-electrode regions, and a suppression region, which is a region where the generation and/or the move of a carrier is suppressed, is present within the non-inter-electrode region. The present technique is able to be applied, for example, to a solid-state imaging device which uses an organic film.


Object: To evaluate the effects of DongMeiYin(DMY) on Matrix Metallo Proteinase-9 (MMP-9)in the diabetic rats,and to investigate the mechanism of DMY in preventing and treating early diabetic nephropathy(DN).Methods: The rat early DN models were induced by injection streptozotocin (STZ).The model rats were randomly divided into the model group,DMY group,Valsartan group.The course of treatment continued 8 weeks.Observing the changes of MMP-9 in the renal cortex.Results: Compared with the normal group,the level of MMP-9 decreased in the model group,the two treated groups could increased the level of MMP-9.especially the DMY group had the best effect.Conclusion: The protective effect of DMY on renal structure may be achieved by modulating the level of MMP-9.


The work described aims to further the development of welding techniques for thermally asymmetric joints. A typical example is to be found in the construction of modern t i tanium heat exchangers where thinwalled tubes are welded to relatively massive tube plates. A simple model was set up to compare the heat input requirements for the thick and thin components of an asymmetric joint, and to describe the effects of component dimensions, material thermal properties and welding parameters on the discrepancy between these requirements. The model shows that the effects of thermal asymmetry may be reduced by the use of a fast-moving high density heat source. The approach to symmetry improves as the welding speed is increased, and, for a given speed, is a function of the thermal diffusivity of the material and the component dimensions. Metals of low thermal diffusivity, such as t i tanium and steels, are favored, and for these materials a good approach to symmetry is predicted wi th speeds above 20 mm/s (47 ipm) and a tube thickness of 0.5 to 1 mm (0.02 to 0.04 in.). Experimental laser welds were made between titanium sheets, 1 mm (0.04 in.) and 12 mm (Vi in.) thick, to simulate the tube-to-tube plate joint configuration. The penetration characteristics were shown to be greatly superior to those obtainable wi th conventional CTA welding. Laser welding is thus effective in overcoming the heat sink problems associated with joint asymmetry. Its advantages include a narrow weld bead and heat affected zone, reduced HAZ grain growth, reduced danger of atmospheric contamination and a high tolerance to variations in welding parameters and joint f it-up. The main problems to be overcome include weld bead root porosity and, for large structures, laser beam manipulation.


The RS flip-flop is a basic element of the computer random access memory. The same structure provides new properties by using fuzzy operations instead of Boolean ones. Applying probabilistic fuzzy operators, we have found that bi-stability of RS flip-flop is changed into monostability, i.e. the memory achieves the ability of spontaneous forgetting. When two fuzzy flip-flops are interconnected in a proper way, Hebbian learning occurs. This means that if inputs occur simultaneously, the outputs are turned up for much longer period, comparing to pulses which are not overlapped. This property can be applied to RS flip-flops grid network. In this case, the excitation of flip-flop outputs depends on input pulses (their magnitudes, durations and positions in the time scale) as well as on a connection topology of the grid.


ackground In primary percutaneous coronary intervention for acute ST-segment elevation myocarial infarction (STEMI), the use of drug-eluting stents (DES) is still controversial. Several randomized ontrolled trials of DES, compared with bare-metal stents (BMS), with short-term follow-up showed a eduction in target lesion revascularization (TLR), but no differences in rates of cardiac death or reurrent myocardial infarction. Moreover, the occurrence of (very) late stent thrombosis (ST) contines to be of major concern, and, therefore, long-term follow-up results are needed.


Cluster fig, goolar in hindi, is a medicinal fruit, widely found in India. It is a rich source of iron and other micronutrients. Wheat is a staple food of Indian diet which is an energy dense food. It is a good source of carbohydrate & protein. Pearl Millet is most widely grown type of millet. It is known for its calorie value; vitamins & minerals present in it. Mung bean which belongs to the family of legumes has high calorie in it & is also a very good source of protein & poly-unsaturated fatty acid. For this study cluster fig powder, germinated wheat flour, germinated mung bean flour, germinated pearl millet, carrot powder & beetroot powder have been used. The product development was done using the above-mentioned ingredients. Two products with three treatments of varying quantity of ingredients was used for product development.  The developed products undergone sensory and proximate analysis. Each treatment has three different replications to minimise the error during proximate analysis. Each product has three treatments for sensory evaluation and nutritional assessment with three different replications.
The organoleptic evaluation highlight that the taste becomes bitter and the acceptability decrease with. Increased quantity of cluster fig. The proximate analysis concludes that with increase in the quantity of cluster fig, the iron and zinc content of the products increase.  This study shed light on evaluation of organoleptic acceptability and nutritive & medicinal properties of cluster fig. It also provides idea on how much quantity of cluster fig powder & other ingredients should be used in various processed convenience healthy food. The research aims at highlighting the use of cluster fig which is widely available in India but has never been used to make convenience.


The discussion of symmetry in modern mathematics syllabuses can be taken a stage further in the sixth form to show how symmetry can often be used to simplify the solution of certain types of problems. This article gives just one example, that of determining the eigenvalues and eigenvectors of an n × n matrix. The theory involves two steps. In the first we show how the eigenvalues of a matrix M can under certain circumstances be found from those of a commuting matrix P. In the second step we show how to construct, from the symmetry properties of matrix M, commuting matrices P whose eigenvalues are readily found.


The mineral element content in Chimonobabusa utilis(Keng) Keng f.with three different extent interference was studied in Zunyi,Guizhou province.The results indicated that,first,contents of mineral elements were different in stems,branches and leaves of C.utilis;Second,the Mg,Ca,Fe,K,P,N mineral elements were most abundant in leaves(4.444 0, 13.266 3,0.795 8,0.667 0,1.967 1,15.568 4 g/kg),more in branches(1.606 5,0.675 9,0.367 8,0.609 7,1.482 8,6.100 4 g/kg),less in stems(0.709 7,0.470 3,0.126 8,0.376 2,0.668 9,2.248 1 g/kg);Third,different degrees of interference had significantly impact on the content of mineral elements in the bamboo.The content of Ca in stems was influenced by serious interference moderate interference mildly interference.K in branches: Mildly interference moderate interference serious interference.P in branches: Mildly interference serious interference moderate interference.N in branches: Mildly interference moderate interference serious interference.Mg in leaves: Serious interference mildly interference moderate interference.K in leaves: Mildly interference moderate interference serious interference.P in leaves: Serious interference mildly interference moderate interference.N in leaves: Serious interference mildly interference moderate interference.Last the level of Fe,K,N were higher under mildly interference,the level of Mg,Ca,P were higher under serious interference,but the effect of moderate interference on mineral element content was very small.


A novel framework called memory-based forecasting is proposed to forecast complex and time-varying natural patterns. In this framework, past patterns similar to the present pattern are retrieved, and the forecast pattern is produced by using the patterns that follow the retrieved sequences. We represent the dynamic features of a sequence by using the spatial distribution of the patterns, velocity field, and temporal texture features; the sequences are transformed into paths in eigenspaces. The relationship between retrieval error and prediction error is modeled to define a similarity measure for retrieval. Forecast images are constructed from a future point in the eigenspace which is estimated by a nonlinear prediction scheme. Several experiments using weather radar images confirm the effectiveness of our method especially for drastically changing patterns.


Abstract : The preliminary study was conducted to determine the GSE required for the heavy-lift helicopter (HLH) early enough in the program to allow ample time for development/procurement of long lead time items. The HLH aircraft systems were analyzed during the preliminary design stage to establish maintenance concepts, identify the necessary organizational and direct support level tasks, and select equipment suitable for performing the tasks identified. The selected equipment was classified as existing as-is, existing requiring modification, or not available and requiring new design and development effort. The elapsed maintenance time and the number of personnel required to perform organizational and direct support level tasks in the Army aviation environment were determined. In some instances, several alternate approaches for GSE were identified which will require trade-offs to complete the equipment selection process.


Introduction:
 Phase 2 cardiac rehabilitation (CR) is a 36-session medically supervised exercise and educational program prescribed for patients with a variety of cardiovascular conditions. The beneficial effect of physical activity on BP is well established. Whether CR participation affects exercise capacity (EC) and outcomes in patients with resistant hypertension (RH) is unknown.

 Methods:
 Participants enrolled in Phase 2 CR at a tertiary academic medical center between 2012 and 2017 were evaluated. Of 504 total CR participants, 298 completed both entry and exit stress testing. Participants were defined as having RH if they were taking 3 antihypertensive medications including a diuretic, with a resting SBP > 130 mm Hg, or 4+ antihypertensive medications, regardless of BP. The percentage change in EC from CR entry to exit and cardiovascular outcomes were compared between patients with and without RH.

 Results:
 Of CR participants that completed both entry and exit stress testing, 8% (24) had RH, 62% (185) were non-resistant hypertensives, and 30% (89) had normal BP. Compared to other CR participants, those with RH exhibited lower absolute baseline EC (5.4 +/- 2.4 metabolic equivalents (METs) vs. 6.9 +/- 2.6 , p=0.007) and lower EC after completion of CR (6.6 +/- 2.6 METs vs. 8.4 +/- 3.0 , p=0.004); but demonstrated a similar relative increase in EC (31% vs 28%, p=0.74) pre to post CR. Among all participants in CR (n=504), participants with RH (n=36) were more likely to be hospitalized within 2 years of completion of CR (67% (24/36) vs. 39% (184/468), p=0.002) and demonstrated a trend toward increased mortality (8% (3/36) vs. 4% (18/468), p=0.18) over the subsequent 5 years.

 Conclusion:
 Although less fit at baseline, CR participants with RH have a similar relative improvement in EC compared to all other CR participants. However, among CR participants with RH, these data demonstrate that a low absolute level of EC is accompanied by a greater likelihood of being hospitalized in the two years following CR.


This research is used a combination of both known and unknown attacks, Not only unknownattacks are difficult to detect and mitigate, their attack scenarios are also unpredictable, although such attack scenarios consisting of unknown attacks arepossible, they are often not taken into account when hardening the networked system because it is difficult to measure the security posture of them On theother hand, the occurrence of unknown attacks is growing rapidly [1,2]. Thus there is an urgent need for assessing the combined effects of both known and unknown attacks,unknown attacks consisting of unknown vulnerabilities, unknown devices, and unknown attack paths. This research aims to address the aforementioned problems by classifying un-known attacks, and incorporate them into the HARM.


In some examples, the present disclosure relates to deliver electrical stimulation therapy to a patient systems, equipment and technologies. In one example, the present disclosure relates to a method of having a series of pulses of alternating polarity pulses transmitted to the patient gastrointestinal tract. The series of pulses including at least a first pulse of a first polarity, a second pulse of a second polarity and a third pulse of a first polarity, wherein said first, second and third pulses in this order directly, continuously transmitted. First and second pulses separated by a first time delay, and the second and third pulse are separated by a second time delay. In some examples, to deliver electrical stimulation to a patient's gastrointestinal tract.


Monolayer tin sulphide (SnS) is an extraordinary two-dimensional material with semiconductor nature. We have explored the doping effects of Gallium (Ga) and Arsenic (As) atoms on the electronic and magnetic properties of monolayer SnS using first-principles calculations. We find that the doped system are energetically stable due to high binding energies. Both the dopants retain the semiconductor nature of monolayer SnS with a tuneable band gap. Interestingly, spin-polarization with magnetic moment of 1.00 μ B has been induced in both Ga- and As-doped monolayer SnS. Moreover, the realization of magnetic anisotropy energy (MAE) could pave a way to utilize Ga- and As-doped monolayer SnS for applications in magnetic semiconductor devices.


Two 1D coordination polymers were synthesized by reaction of two ligands, 2-amino-4-picoline (2A4Pic) and quinoline-6-carboxylic acid (Qu-6-COOH) with two metal (II) nitrate (M = Cd and Cu) in the presence of azide as a linker. The synthesized metal complexes [Cd(2A4Pic)2(N3)2]n; (1) and [Cu(Qu-6-COO)(N3)(H2O)]n; (2) were isolated in single crystals and their X-ray structures revealed a 1D polymeric structure. Due to symmetry considerations, the asymmetric formula is half a [Cd(2A4Pic)2(N3)2] unit for 1 and one [Cu(Qu-6-COO)(N3)(H2O)] unit for 2. In complex 1, the Cd(II) is hexa-coordinated with two 2A4Pic molecules and four μ(1,1) azide units. Hence, the CdN6 coordination environment has a slightly distorted octahedral geometry. In 2, the Cu(II) is hexa-coordinated with three different ligands (Qu-6-COO¯, H2O and μ(1,1) N3¯) where all are connectors between the crystallographically related Cu(II) sites. Additionally, complex 2 distorted CuN2O4 octahedral geometry. In both complexes, the polymer arrays are connected by N…H hydrogen bonds and π–π stacking interactions. Based on Hirshfeld analysis, the percentages of N…H contacts are 43.1 and 27.4% for 1 and 2, respectively, while %C...C are 5.6 and 9.3%, respectively. Analysis of Cu-N, Cu-O, and Cd-N bonds using DFT calculations showed predominantly closed-shell coordination interactions with little covalent characters. Additionally, the negatively charged ligand groups were found to compensate the positive charge of the central metal ion to a larger extent than the electrically neutral ligands.