Patent abstract: "estra-1,3,5 (10), 16-tetraene-3-carboxylic-xamidas". the invention relates to compounds of akr1c3 inhibitors (i) and to processes for the preparation thereof, the use thereof for the treatment and / or prophylaxis of diseases and to the use thereof for producing medicaments for treatment and / or prophylaxis of diseases, specifically bleeding disorders and endometriosis. 1/1


Link to the campaign website. The aim of the campaign is to provide a support network for mesothelioma sufferers and their families in the South West.


The conditions of the stress strain and the characteristics of the metal flow in the forming process of the TSPP caps are researched. It has analyzed the causes of the metal flow in theory and in the ways of the metal tissue conditions of the aluminium plate. At the same time, it also has analyzed the causes of the metal flow in the ways of the roughness and the defects of the aluminium plate surface. It also has proposed the measures of controling the metal flow on the aluminium TSPP caps.


In this paper, we propose a new theory of special relativity and its fundamental principles such as the principle of covariance and symmetry and transformation systems.


PURPOSE: An L-methionine which is converted from O-succinylhomoserine from L-methionine precursor is provided to use as a animal feed or animal feed additive and food or food additive for human. CONSTITUTION: An Escherichia sp. derived strain which produces O-succinylhomoserine is formed by inducing and enhancing homoserine O-succinyltransferase activity (EC184.108.40.206), having feed back resistance to the methinonine, and enhancing aspatokinase or homoserine dihydrogenase activity (EC184.108.40.206 or 22.214.171.124).


The 3D models of partial pipe,magnetization structure of the magnet yoke magnetization method and outer air are built using the finite element method.Through calculation,the effects of coil ampere turns,sectional area of iron core and the air gap of the contact surface to the distribution of magnetic induction field in pipe wall were quantitatively analyzed.When there were columnar defects and interstitial defects,the distribution of the magnetic leakage field was solved.The research results indicate that the more of the ampere turns,the more of the sectional area of iron core and the less of the air gap,the bigger of the magnetic flux density in pipe wall.There is a peak and change of direction in the magnetic induction field of the defects.


This article examines whether changes in the generosity of the unemployment benefits (in particular, the
potential benefits duration) influence the entry of older workers into the unemployment benefits system.
The analysis is based on a law change to the benefit rules which occurred in Spain in July 2012, when the
eligible age for an extended benefit to older workers was raised from 52 to 55, and on data from the administrative records of the Spanish Public Employment Service. We analyse empirically the changes in the
age pattern of unemployment benefit inflows before and after the reform, on the one hand, and the effect
of the legal change on the age at the date of unemployment benefit admission, on the other hand. Our
findings suggest that reducing the potential benefits duration affects the pattern of admissions, transferring entries to higher ages, and that the age at which older workers begin to receive benefits increases by
six months for certain categories of workers.


A stable dual-wavelength erbium-doped fiber laser (DW-EDFL) in the single longitudinal mode (SLM) with a Mach–Zehnder interferometer (MZI) and a saturable absorber loop (SAL) is proposed and demonstrated experimentally. Dual wavelengths are obtained with different MZI arm lengths. After the first mode selection of the tunable fiber Bragg grating, SLM operation of the dual-wavelength is acquired by the SAL based on the Vernier effect and spatial hole burning, which induce an auto-tracking narrow bandwidth filter with an optical coupler and a 2 m unpumped erbium-doped fiber (EDF). The output of the DW-EDFL shows good performance, achieving 1.08 kHz at dual wavelengths of 1558.67 nm and 1558.77 nm. The interval of the dual wavelength is 0.1 nm, which has a good agreement with the theoretical value, and the peak powers are  −5.508 dBm and  −5.993 dBm, respectively under 170 mW pump power. Meanwhile, because of the automatic tracking of the wavelength of the SAL, the optical power instability and beating frequency fluctuation of the dual wavelength are less than 0.5 dB and 0.5 MHz, respectively, showing favorable stability.


This thesis was designed to study causes and effects of changes in plasma sodium and osmolality during pregnancy and labour. The physiological changes of early pregnancy include reduction in plasma sodium and osmolality, as well as increased ventilation with reduced arterial pCO2. These changes are usually considered due to progesterone. Some studies have however correlated these two events and found that reduction in osmolality and strong ion difference (SID, the difference between strong cations and anions) may predict respiratory changes in pregnant women. We hypothesised that changes in osmolality should influence ventilation also in non-pregnant women and men, and we therefore studied the ventilatory response to lowered and increased osmolality in healthy volunteers, ten men and nine women. Ingestion of water and intravenous infusion of hypertonic saline 3% caused osmolality to decrease and increase, respectively. SID and base excess decreased in both conditions, and a respiratory compensation was observed during water loading, but although the metabolic acidosis was more pronounced during salt loading, no respiratory compensation was observed. The principal influence of osmolality on ventilation could be inhibitory when osmolality is increased, but this inhibitory effect could cease at decreased osmolality. The hyperventilation observed during pregnancy often exceeds the respiratory compensation observed in our study participants, but this remains to be explained. We also studied the feto-maternal osmotic and electrolyte relationship, and contrary to the literature, we found that fetal plasma sodium and osmolality were higher than maternal levels. Our results indicated that the physiologic hyponatraemia of pregnancy caused both a compensatory respiratory alkalosis that favours removal of fetal CO2, as well as an osmotic gradient that favours water transport to the fetus. This unifying explanation of maternal physiologic adaptation and feto-maternal relationship differs from the conventional explanatory model that considers the respiratory alkalosis primary, and the metabolic acidosis compensatory. In addition to the physiological lowering of plasma sodium in the pregnant woman, hyponatraemia may develop during labour. We included 287 women during labour in a prospective observational study, and found that hyponatraemia was common following long lasting labour. Sixteen women (26 %) of those who received more than 2.5 liters of fluid during labour developed hyponatraemia ≤130mmol/L. Multivariate analysis revealed that hyponatraemia was significantly correlated to total fluid volume, but not to oxytocin or epidural analgesia. All women consumed a similar hourly fluid volume of approximately 300 milliliter, but during long lasting labour, probably with an increased secretion of vasopressin, free water clearance was reduced, and hyponatraemia could develop. Reduction in plasma sodium during labour also significantly correlated to instrumental delivery. We therefore studied the effect of hyponatraemia on human myometrium in an in vitro study. Hyponatraemia induced reversible changes with increased frequency of contractions and also of multiphasic contractions. These changes could indicate decreased myometrial contractility. In the second part of the study we found that initial multiphasic response to increasing doses of oxytocin was significantly more frequent in the hyponatraemic solution. These results indicate that hyponatraemia could be one of several factors leading to dystocia. Electrolyte free solutions should not be administered during labour, and a bedside registration of fluid consumption would be a simple preventive measure against hyponatraemia. LIST OF SCIENTIFIC PAPERS I. Vibeke Moen, Lars Brudin, Mats Rundgren, Lars Irestedt Osmolality and respiratory regulation in humans Respiratory compensation for hyperchloremic metabolic acidosis is absent following infusion of hypertonic saline in healthy volunteers Anesth Analg. 2014; 119: 956-64. II. Vibeke Moen, Lars Brudin, Mats Rundgren, Lars Irestedt Hyponatraemia complicating labour. Rare or unrecognized?A prospective observational study BJOG 2009; 116: 552-61. III. Vibeke Moen, Lars Brudin, Anette Ebberyd, Maria Sennström, Gunvor Ekman-Ordeberg, Mats Rundgren, Lars Irestedt Hyponatraemia reversibly affects human myometrial contractility An in vitro pilot study


Thermal properties and dispersive capacity of diffractive optical elements were expounded in this paper, and the conclusion that optothermal expansion coefficient of diffractive optical element is independent of refractive index of the material was derived. The design method to athermalize the hybrid infrared optical system was studied, a new hybrid system with diffractive surface was structured on the foundation of refractive/reflective optical system using optical design software ZEMAX, and the surface was simulated by MATLAB. The image quality was improved obviously compared with the one without diffractive surface. The system worked at 3.7~4.8μm band with its' effective focal length of 70mm, field of view of 2° and possessed better athermal performance in the temperature range -40°~+60°. The image quality achieved diffractive limit, besides, a compact structure, small volume and light weight were other advantages of the hybrid system.


A grid tied photovoltaic system using modular multilevel inverter topology is proposed in this paper. Basic unit structure of modular multilevel inverter used in this system is capable of converting DC power from PV array to AC power for feeding power to the household loads or utility grid. The proposed modular multilevel inverter structure has lesser power electronic devices compared to the existing multilevel inverter topologies. The proposed system generates a nearly sinusoidal signal and achieves better output profile with low total harmonic distortion. Simulation of the proposed system is carried out in MATLAB/Simulink software and the results are presented.


The January issue of Diabetes Care includes two papers with considerable practical relevance for primary care.

The first document is a "position statement" from the American Diabetes Association (ADA), the American Heart Association, and the American College of Cardiology. Until lately, the conventional wisdom had been that intensive glycemic control probably prevents cardiovascular complications in patients with type 2 diabetes. But, in three randomized trials published recently and reviewed in Journal Watch (JW Dec 29 2008), intensive glycemic control did not lower rates of cardiovascular events …


AbstractIn this paper several integral representations for the generalized fractional order Mathieu type power series $S_\mu (r;x) = \sum\limits_{n = 1}^\infty {\frac{{2nx^n }}
{{(n^2 + r^2 )^{\mu + 1} }}(r \in \mathbb{R},\mu > 0,|x| \leqslant 1)}
$ are presented. Also new integral expressions are derived for the Butzer-Flocke-Hauss (BFH) complete Omega function.


The present research was conducted in two assays, with the herbicides trifluralin, nitralin and EPTC in two dosi, to verify the weed control, to observe the possible phytotoxicity effects on the crop after re-application in the same agricultural year, and to determine the possible residues in the soil, in the beginning of the next agricultural year, that might affect suceptible subsequent crops. The determination of possible residues in the soil was made by root and shoot bioassays using the sorghum (Sorghum bicolor (L . ) Moench. ) as test plant. There was a good control of weeds by the herbic ides. The purple nutsedge (Cyperus rotundus L.) was controlled only by EPTC. Spanish needles (Bidenspilosa L. ) and broom weed (Sida spp) were not controlled by the herbicides. None of herbicides presented phytotoxic it y effects to the bean crops even after re-applications in the same agricultural year, and residues were not found in the next agricultural year, after re-application in the prior year.


And so, as there is but One who has come out of the temptations that are in the world with white garments; as there is but One who has felt and shown that unity of will with God which means Sonship; as there is but One who has made it manifest both by the consistency of His claim with His conduct and by the unbroken experience of all the saints, that He has returned to the glory which He had with the Father before the world


A method for processing of network topology data, comprising the steps of: a) extracting data from a data storage, data representing a first illustration of a network topology in a first data format; b) generating data representing a predetermined set of rules according to a modified second mapping of the network topology; and c) transferring the second image of the network topology representing data in a data memory in a second data format, wherein d) for a period analysis in a schematic or layout simulation in the second data format is assigned to each section of the network, a corresponding line model and is associated with a model and vias ports and Terminators for a S-parameter simulation are added.


A carotid body tumour (CBT) is rare and most commonly arises from the neural crest tissue. It accounts for less than 0.5% of all neoplasm.1 It may also originate from the chemoreceptor organs which are found in the adventitia layer of the carotid arteries bifurcations. They often present with asymptomatic neck masses, and precaution should be made in the attempt to excise the tumour as it is closely related to vital structures. We present a case of carotid body paraganglioma, its difficult surgical excision and outcome.


innovations / volume 10, number 1-2 © 2015 Paul Breloff Paul Breloff is the founding Managing Director of the Accion Venture Lab. Accion Venture Lab, launched in 2012, is a seed-stage impact investment initiative that provides small amounts of capital (up to $500,000) and management support to jumpstart game-changing financial inclusion startups around the world, promoting better financial services to more people at the base of the pyramid (BOP). Lack of financial access is a massive global problem. At Accion we believe, and the research shows, that the right financial tools can make or break whether someone will be able to take advantage of an opportunity (e.g., invest at the right time to grow a business) or absorb a financial shock (e.g., pay for an emergency medical procedure without spiraling into debt). According to the World Bank's Global Findex Database 2014, roughly two billion people around the world lack access to formal financial services. Our efforts address this widespread issue by helping to provide access to financial tools that help underserved customers—particularly low-income customers and small business owners—improve their lives. A reliable place to borrow and save, for example, can help a household manage uneven cash flow, smooth consumption, and build working capital; insurance can help mitigate risk and manage shocks; new types of payment services can help reduce transaction costs and keep money with families, rather than big money transfer organizations. Evidence also shows that financial inclusion is positively correlated with growth and employment at the macro level. Venture Lab is an in-house, strategic venture capital arm of Accion, a financial inclusion nonprofit organization headquartered in the United States, with offices in Colombia, Ghana, and India, and with 200 staff members around the globe. Although this strategic, in-house venture capital model is common among mainstream banks (e.g., Citi Ventures, American Express Ventures), it remains uncommon among nonprofits, which rarely have the resources to foot the bill for exploratory investment arms. Venture Lab's purpose is to spur innovation in financial inclusion, specifically innovation led by the earliest and most unproven startups. We believe that market incumbents— the big banks, credit card companies, and remittance players—need a healthy dose of inspiration or perhaps fear from a new breed of entrepreneurs poised to shake up the status quo in global finance. Accion Venture Lab Paul Breloff


Abstract: Alcoholic Wernicke's encephalopathy has been commonplace in Australia for many years and, as this syndrome is attributed to a deficiency in the diet, it should be preventable. This study employs conventional cost‐effectiveness methodology to compare the economic efficiency of several thiamin‐supplementation alternatives that have been proposed for the prevention of Wernicke's encephalopathy. A series of rankings of these measures is derived from an estimated cost per case averted for each of the alternatives studied. These rankings identify the least cost‐effective thiamin‐supplementation alternative as that of enriching bread‐making flour with thiamin.


There were observed 102 children with perinatal pathology of central nervous system (CNS). A hypoxicischemic encephalopathy formation in newborns was monitored. There was revealed a high prognostic value (PPV) of congenital hypotrophy (PPV= 76,4%), pulmonary ventilation (PPV= 85,1%), neonatal infection (PPV=73,8%), anemia in newborns (PPV=63,0%), reanimation and intensive therapy (PPV=75,6%) in the formation of psycho-neurological invalidism.


E-learning is now-a-days playing a vital role in our learning process. One of the most challenging things for developers in e-learning system is to secure data transmission. Being a fully online system, during transmission of study materials from developer to student, hacker can change or destroy those. At a student's point of view, non-repudiation is also an important issue in e-learning system. In this paper, we have only consider transmission of the study materials from developer to student, where verification of digital signature will check the hacking and the developer can't deny from sending the material. To provide authenticity and strong nonrepudiation, we wrapped the ElGamal Digital Signature in object oriented models to get the also the benefits of the object oriented approach.


During the past decades, research collaboration between researchers from different disciplines has become more frequent. However, there is a need to look into the generic modalities and challenges. The article explores a series of potential obstructions to cross‐disciplinary collaboration of methodological and epistemological nature. Furthermore, a number of contextual, inhibiting factors are outlined. As means of overcoming the obstacles, the importance of mutual knowledge, allocation of adequate time and conducive research management is emphasised. New teams may benefit from tutoring by facilitators, who can help to make problem areas explicit and negotiate solutions. Owing to the training background of the author, most of the examples are drawn from the interface between biomedicine/natural science and applied medical anthropology. However, the issues raised basically apply to all sorts of cross‐disciplinary research collaboration in various combinations.


The queue machine computation model is an evaluation scheme for expression trees, in which the input operands of operations are taken from head of a queue, and its result is put onto tail of the same queue. A series of operations for this model are generated by traversing the expression tree(s) from its leaf nodes in reverse of the breadth-first ordering. Since nodes with the same level in an expression tree can be processed concurrently, the generated operations can also be processed in parallel without reordering. In this paper, we describe a design of superscalar processor using this computation model.


Virtual Reality (VR) is increasingly being used to promote mindfulness practice. However, the impact of virtual and multimodal interactive spaces on mindfulness practice and presence is still underexplored. To address this gap, we conducted a mixed-method user study (N=12). We explored the impact of various multimodal feedback, in particular tactile feedback (passive haptic feedback by artificial grass) and auditory feedback (footstep sound) at feet level on both mindfulness and presence. We conducted semi-structured interviews and collected quantitative data through three validated questionnaires (SMS, IPQ, WSPQ). We found a significant effect of passive haptic feedback on presence and mindfulness. Tactile feedback improves the focus on the self, facilitates spatial presence and increases involvement. Auditory feedback did not significantly affect presence or mindfulness. While ambient sound was perceived as beneficial for presence, footstep sound subjectively disrupted both presence and mindfulness. Based on our results, we derive design recommendations for multimodal VR applications supporting mindfulness practice.


The cultivation of medicinal plants and the production of bioactive compounds derived from them are of fundamental importance and interest, not only at the pharmacological level but also in nutraceutical and cosmetic industries and in functional foods, as well as plant protection in agriculture. In order to respond adequately to the increased demands of the global market from a quantitative and qualitative point of view and to guarantee environmental sustainability of the productions, it is necessary to resort to innovation tools, such as tissue culture in vitro technology. Nowadays, it is well known that the cultivation through the Temporary Immersion System (TIS) in a bioreactor has considerable advantages both for the in vitro mass production of the plants and for the production of secondary metabolites. The present review focuses on the application of TIS during the last two decades to produce biomass and bioactive compounds from medicinal plants. Indeed, almost one hundred papers are discussed, and they particularly focus on the effects of the culture system, vessel design and equipment, immersion time and frequency, and substrate composition for 88 medicinal species in TIS bioreactor culture.


Metal matrix composites offer unique opportunities for achieving multifunctionality in materials. Nowadays it is commonly considered that high damping materials which haveboth the good mechanical properties as structural materials and the high damping capacity for vibration damping are the most direct vibration damping solution. In this work,the thermo-mechanical behaviour of as cast Al7075 alloy and Al7075/basalt short fiber composites was investigated as a function of temperature using Dynamic Mechanical Analyzer (DMA). The composites were prepared by the melt-stirring technique with 2.5, 5, 7.5 and 10% by weight of basalt short fiber. From the study it was observed that within the scope of this investigation as the temperature was increased, the loss modulus and damping capacity increases while the storage modulus decreases. However, both loss modulus and storage modulus increase marginally with the increase in basalt short fiber contents. The damping capacity, on the other hand, shows an increase with the increase in basalt short fiber content as well as with temperature. In all the cases, it can be seen that damping capacity increases as basalt fiber content increases due to the presence of basalt fibers, which significantly accelerate the ageing and precipitation kinetics in matrix alloy. This acceleration is attributed to the decrease in incubation time for nucleation and growth of precipitates resulting from an increase in dislocation density due to coefficient of thermal expansion (CTE) mismatch between the matrix and the reinforcement.


Optical imaging techniques, in particular fluorescence imaging is nowadays widely used in biomedical research. Among those optical imaging approaches, fluorescence microscopy is one of the most established and routinely used techniques in daily research. Unfortunately microscopy techniques are only applicable to study molecular and cellular processes in cell culture or tissue samples. Therefore an imaging strategy which would allow to apply the wealth of tools that have been developed for optical microscopy to intact organisms such as mice would be very attractive. Fluorescence molecular tomography (FMT) is such a promising and powerful macroscopic imaging technique. Due to significant technological progress during the last years FMT has emerged as interesting molecular imaging solution for various fields in biomedical research. FMT allows a three-dimensional reconstruction of fluorophore distribution in vivo by scanning an excitation source pattern on the sample surface and collecting the diffuse light by an array detector. In contrast to first contact setup implementations where the animal is place vertically in a liquid filled imaging chamber connected to a limited number of source and detector fibers, recent setups provide a more convenient horizontal non-contact measurement geometry. These setups are more flexible and have a large number of source/detector pairs which leads to improved reconstructed image resolution. Compared to straightforward implementations of planar imaging techniques where quantitative measurements are impossible to achieve, FMT allows depth resolved information and therefore the quantification of fluorophore distributions which is important for biological investigations. The major advantage of optical imaging techniques are the high sensitivity which makes it suitable to detect low concentration of target molecules in tissue. Furthermore, optical reporter systems such as fluorescent dyes or bioluminescent and fluorescent reporter proteins are stable molecules and can be easily targeted to report on specific molecular processes in vivo. Additionally, the techniques are relatively inexpensive, which facilitates their protrusion into the biomedical research community. The development and construction of a non-contact FMT setup was the first goal of this thesis. In a preliminary step the theoretical background of FMT and especially the concepts allowing for non-contact FMT were discussed in details. A second section describes the technical realization of the setup including further improvements compared to already published examples such as an integrated filter switch mechanism and preparative steps for multispectral imaging. Different in vivo applications demonstrated a proper function of the implemented method: In a first experiment load induced changes in bone osteoblast and osteoclast activity responsible for bone formation and resorption were evaluated in mouse tail vertebrae using a commercial available molecular fluorescence probe targeting hydroxyapatite. Clear changes in the reconstructed fluorescence intensity were observed for different loading forces and furthermore the FMT readouts was shown to correlate well with a X-ray computed tomography (CT) readout. A further proof demonstrating the feasibility of quantitative FMT imaging was performed on a second experiment where the objective was to image cervical lymph nodes with an indocyanine green (ICG) labeled antibody in an inflamed mouse model. In this study the localization of the inflamed and healthy lymph node was shown with help of reconstructed ICG distribution. Interestingly even signals from the lymph nodes in control animals could be observed at the specific wavelength used. Finally, FMT was applied in a mouse model of Alzheimer's disease where the time course of fluorescence intensity elicited by an oxazine derived dye, which has been shown to specifically bind to aggregated beta-amyloid in the brain cortex, was compared in transgenic animals developing amyloid plaques to wild type litter mates. The fluorophore concentration could be clearly localized in the cortical region of both animals: the slower dye clearance in the brain of transgenic animals indicated an enhanced dye binding to the Alzheimer's plaques. In summary, a successful operation of the designed FMT method could be shown by means of various in vivo applications resulting in well resolved reconstructed fluorophore distributions and its quantification under in vivo conditions. A major limitation of FMT, which is characterized by high sensitivity sufficient for providing molecular and functional information, is the relatively poor spatial resolution in comparison to structural/anatomical imaging modalities which may render the allocation of molecular data to a specific anatomic structure difficult. This lead to the second major goal of this project where the elimination of this constraint was intensively studied. The result was a novel hybrid multimodal imaging concept where a combination of non-contact FMT and high field MRI was used for simultaneous measurements. Preclinical MRI is an attractive counterpart to FMT as it provides high resolution images of structures due to excellent soft tissue contrast. This complementary anatomical information would help to better localize and furthermore improve the reconstructed fluorophore distribution. With a non-contact free space FMT design principle restrictions of recently published setups such as low numbers of source/detector pairs in a rigid configuration, fiber based bulky construction, small field of view coverage and related limited diffusive light collection could be eliminated. The here presented newly developed setup is working in non-contact fiber-free reflection geometry where the optical detector array is placed in close proximity to the sample in the isocenter of a 9.4T animal MRI scanner. The sample illumination is provided from outside the bore of the MR scanner and is freely adjustable to the geometry of the sample. First performance tests of the setup in tissue mimicking silicone phantoms using a 32×32 single photon avalanche diode (SPAD) array yielded adequate spatial resolution both in plane and in depth, which correlated well with simulation results. The proof of principle of this first generation setup was demonstrated in a tumor bearing mouse where the distribution of a fluorescent protease probe could be three dimensionally represented and localized with help of an anatomical reference provided by the MR. Based on experiences of the first generation FMT/MRI setup a further improved completely redesigned second generation setup was implemented. The second setup is primed to be used in transmission or reflection mode and the limited detector resolution was extended by using newly developed detector technologies having higher number of pixels available. A specially designed 256×256 CMOS detector array could be attached to the system. The small field of view limiting the optical imaging in the first setup was widened with an improved objective lens and a larger detector size. A further gain in field of view was achieved by increasing the focal distance which was achieved by scanning the sample surface from the side and not as in the previous version from the top. Moreover simplifications for the handling were achieved by attaching the platform to a rigid rail system consisting of two carbon rods fixed to the MR scanner compared to the less stable fixation used in the first version. First tests on tissue mimicking silicone phantoms demonstrated the proper function of both the MR and the optical part during simultaneous acquisitions. Furthermore it was found that the spatial resolution and the sensitivity is comparable to stand alone FMT setups working with the same principle. In vivo experiments in an Alzheimer's disease mouse model performed simultaneously with the FMT/MRI setup showed comparable results to the presented study with the stand alone FMT system. Summing up, based on a new idea of combining FMT and MRI imaging a first generation and improved second generation dual-modality setup allowing simultaneous measurements was designed and characterized. Performance tests on tissue phantoms and in vivo experiments in mice demonstrated a correct functioning of both modalities and showed the potential of such hybrid setups in providing complementary information required for a comprehensive understanding of the processes investigated.


In this paper, based on the Rayleigh quotient and its generalized Rayleigh quotient, two treatments are developed to solve the complex eigenvalue problems, which arise from the analysis of the optical wave propagation in Slab waveguides with some perfectly matched layers. Numerical examples illustrate that these treatments are efficient and feasible, and the generalized Rayleigh quotient method is better than the Rayleigh quotient method for some eigenvalues with smaller norm.


This chapter explores the ethics of online shaming or crowd-sourced condemnation. Instead of relying upon standard accounts of ethics from western sources, I engage the Indian religious-philosophical system of Jainism in an effort to highlight what might be problematic about the practice of rallying others to shame offending or offensive individuals. Exploring the practice of shaming as it is practiced on the popular blog "Racists Getting Fired," one can see that Jainism gives us a radically new way to diagnose what is wrong with so much of the revenge-seeking online discourse we find ourselves either hating or loving.


Make more knowledge even in less time every day. You may not always spend your time and money to go abroad and get the experience and knowledge by yourself. Reading is a good alternative to do in getting this desirable knowledge and experience. You may gain many things from experiencing directly, but of course it will spend much money. So here, by reading perinatal and pediatric pathophysiology a clinical perspective, you can take more advantages with limited budget.


A program for modeling IC fabrication processes is described. Simulated and measured impurity profiles are shown for a bipolar transistor technology. The simulated profiles are used to study sensitivities in electrical device parameters. A comparison of simulated device performance using process models gives parameters which bracket measured results for 35 die across a wafer.


Scheduling with assignment restrictions is an important special case of scheduling unrelated machines which has attracted much attention in the recent past. While a lower bound on approximability of 3/2 is known for its most general setting, subclasses of the problem admit polynomial-time approximation schemes. This note provides a PTAS for tree-like hierarchical structures, improving on a recent 4/3-approximation by Huo and Leung.


ABSTRACTWe analyzed two sets of Toxichem® controls by gas chromatography and found good agreement with Fisher's listed assay values. The samples are marketed as assay controls rather than standards (preparation target value is unknown) and are a good independent check of a gas chromatography system.


Data-parallel primitives for performing operations on the PM1 quadtree, bucket PMR quadtree, and R-tree spatial data structures are presented using the scan model. Algorithms are described for building these three data structures that make use of these primitives. The data-parallel algorithms are assumed to be main memory resident. The algorithms were implemented on a minimally con gured Thinking Machines CM-5 with 32 processors containing 1GB of main memory. This work was supported in part by the National Science Foundation under Grant IRI-92-16970.


This chapter introduces main concepts, theories and data that are covered in this section of the book. After having discussed the applied ambitions of Herrmann Ebbinghaus the chapter reflects on th ...


In this paper, fatigue life circular cross-section elastic bar under pure fatigue axial loading is studied through principles of linear elastic fracture mechanics (LEFM) coupled with the three-dimensional finite element technique for determination of critical crack size and residual lifetime. Three different initial notch depths are discussed. The relations between aspect ratio (b/c) and relative crack depth (b/D) are obtained, and it is shown that there is great difference in the growth of cracks with different front shapes and initial notch depths.


In a recent UEFA Champions League game between AC Milan and FC Barcelona, played in Italy (final score 2-3), the collected match statistics, classified into four offensive and two defensive strategies, were in favour of FC Barcelona (by 13 versus 8 points). The aim of this paper is to examine to what extent the optimal game strategies derived from some deterministic, possibilistic, stochastic and fuzzy LP models would improve the payoff of AC Milan at the cost of FC Barcelona.


The arrival of the month of June signifies an ending to anoth er rehearsal season for Zion's musical ensembles. A summer break from the regular routine of weekly practices is well-deserved for our volunteer musicians. We give thanks and praise to God for those members of our church family who contribute to the beauty and meaning of our worship. As a way of acknowledging them, we are listing the members of each musical group on the insert in this newsletter. What can I do? • Give these people a word of encouragement and thanks for what they do. They participate because they want to praise God, but God blesses them through kind words from you. • Consider joining one of Zion's choirs,


A regional study shows how the maximum Cu, Zn and Cd levels of Andalusia (South of Spain) were registered in Lepanto, an urban background site located in Cordoba city. These levels were higher than ones registered in
historical industrial polluted areas such as Huelva or the strait of Gibraltar. In this study we carried out an intensive measurement campaign with the aim of investigating the relationship between several metallurgic airborne emissions and the geochemical anomalies observed at the city. The results show how geochemical anomalies (Cu, Zn, Pb and Cd, specially) observed in the ambient air samples collected in the city are closely related to the geochemical profile obtained in the stack and fugitive metallurgy emissions.


The challenge Lifelong Object Recognition, requires exploring how knowledge acquired on previous tasks can be leveraged when learning future tasks, while also memorizing the past tasks, efficiently. This capability is explored under a difficulty-incremental scenario in IROS 2019, lifelong object recognition challenge, where a model is required to perform continual learning under different environmental conditions such as illumination, occlusion, clutter, resolution and camera pose. We show that by using a combination of regularization based lifelong learning and data augmentation, model learning can be made generalized under varying environmental conditions.


With the rapid development of optical communication systems, more advanced techniques conventionally used in long-haul transmissions have gradually entered systems covering shorter distances below 100 km, where higher-speed connections are required in various applications, such as the optical access networks, inter- and intra-data center interconnects, mobile fronthaul, and in-building and indoor communications. One of the techniques that has attracted intensive interests in short-reach optical communications is machine learning (ML). Due to its robust problem-solving, decision-making, and pattern recognition capabilities, ML techniques have become an essential solution for many challenging aspects. In particular, taking advantage of their high accuracy, adaptability, and implementation efficiency, ML has been widely studied in short-reach optical communications for optical performance monitoring (OPM), modulation format identification (MFI), signal processing and in-building/indoor optical wireless communications. Compared with long-reach communications, the ML techniques used in short-reach communications have more stringent complexity and cost requirements, and also need to be more sensitive. In this paper, a comprehensive review of various ML methods and their applications in short-reach optical communications are presented and discussed, focusing on existing and potential advantages, limitations and prospective trends.


This article presents a theoretical discussion about the inclusion of explicit pragmatic instruction as a facilitative tool to develop pragmatic competence in a foreign language. Given the theoretically and empirically informed fact that this competence is generally neglected in the classroom, the rationale here presented may serve as a foundation for foreign language teachers, who face the necessity of helping learners develop pragmatic skills in the target language. Likewise, this article intends to be a prompter for classroom researchers, eager to explore the effect of pragmatic instruction, and the potential developmental stages learners undergo, through the conduction of longitudinal and cross-sectional research studies.


A smooth-walled horn is often preferred over a corrugated horn in high frequency band due to easier and cheaper manufacturing. In the paper, eight original profiles are introduced, and the radiation patterns of optimized horns are contrasted. The conclusion is important for designing a smooth-walled spline-profile horn.


Title Intramolecular Conjugate Addition of α,β-Unsaturated Lactones Having an Alkanenitrile Side Chain: Stereocontrolled Construction of Carbocycles with Quaternary Carbon Atoms Author(s) Yoshimura, Fumihiko; Torizuka, Makoto; Mori, Genki; Tanino, Keiji Citation Synlett, 2012(2), 251-254 https://doi.org/10.1055/s-0031-1290074 Issue Date 2012-01 Doc URL http://hdl.handle.net/2115/51017 Rights © 2012 Georg Thieme Verlag Type article (author version) File Information Syn2012-2_251-254.pdf


The application of the microscope to petrology made it possible to I investigate effectively the history of the foliated rocks and of metamorphism. This was done, as it happens, only a very few years before I began any special study of such rocks, so that the account, of my own work almost corresponds with that of the general progress in a knowledge of them. I was led, after some preliminary efforts, into investigating two distinct problems, each of which, as I soon discovered, presented rather exceptional difficulties. These were the pre-Carboniferous rocks of Charnwood Forest and the serpentines of the Lizard. The problem involved in the one was how far some of them were or had been igneous in origin, lavas, tuffs, and agglomerates, or were stratified rocks, which by pressure and mineral changes had been so altered as to be indistinguishable from some of the former. The other introduced the question of the origin of serpentine, about which in 1873 the utmost uncertainty existed. This, from its associations, led on to investigating the nature and origin of gneisses and schists, so that the history of my own studies during the last forty-five years happens to illustrate. some important aspects of the progress made during that period.


Background: The clinical course of patients with MM is highly variable and, among currently available standard features, the presence of metaphase cytogenetic abnormalities (CA) is the parameter with the single best discriminatory power. The aim of this investigation was to determine, among the 1/3 high-risk patients with CA the W and among the remaining low-risk patients the L.

Patients and Methods: We evaluated the baseline characteristics of > 2500 patients who received at least 1 high-dose melphalan-based autotransplant (AT). Poor risk was defined as pre-AT CA (within 90 days) while good risk was defined as no pre-TX1 CA. Poor outcome was death within 2 years of AT while good outcome was survival for ≥ 5 years. Four groups were identified: 403 patients without CA and >5yr survival (noCA/W), 288 without CA and 5yr (CA/W) and 350 with CA surviving <2yr (CA/L).

Results: Among both CA and no CA groups, univariately significant pre-AT differentiating features between W vs L were serum albumin > 3mg/dL, b2M 10 mg/dL and platelet counts > 100/μL, LDH 3mg/dL, hemoglobin > 10 mg/dL, B2M 100/μL and CRP<6 mg/dL. These independent prognostic factors were almost identical for CA and noCA patients except for Hgb which was slightly more important than albumin in the CA population.

Conclusion: Among MM patients receiving AT, treatment on Total Therapy protocol, higher Pre-AT albumin, hemoglobin and platelet count and lower b2M and CRP confer a survival advantage regardless of cytogenetic status (CA or noCA) and distinguish the W among the high-risk disease from the L among the low-risk patients.


Jeon, In-Jae. (2005). An analysis of task-based materials and performance: Focused on Korean high school English textbooks. English Teaching, 60(2), 87-109. The purpose of this study is to propose some meaningful considerations for communicative material development by exploring the aspects of task-based materials and performance with reference to first year high school English textbooks in Korea. For this purpose, two studies were conducted. The first one was to quantitatively analyze task-based materials in textbooks based on the qualitative analysis criteria supported by Nunan's (1989) theory of task components. The second study was to examine the level of participants' satisfaction with task-based performance through questionnaire research. The results of data analysis show, in accordance with core regulations of the 7 th national curriculum for English represented by task-based learning and activity-oriented language use, that communicative theory of language learning is adequately reflected in the task-based materials of all textbooks. To conclude, a few suggestions are made to enhance the effectiveness of task-based activities in communicative classroom practices: a) task goals and rationale that encourage the learner's motivation; b) authenticity of input data based on real-world situations; c) more emphasis on group work containing problem-solving procedures rather than individual ones; d) proportional representation of activity types and themes, etc.


Supernovae count among the most luminous phenomena in the universe, and as such they have been sought after to serve as cosmological distance indicators. Type Ia supernovae are currently the most commonly used indicators. In this study, we will examine a method for using Type II supernovae as distance indicators, and attempt to prove this method's reliability and accuracy by calculating the distance to the Type II Supernova 1987A and comparing it to results using other methods.


Randy Barnett claims that social orders must address three challenges: problems of knowledge, of interest, and of power. Knowledge problems arise because information is widely dispersed across society, and unless these innumerable bits can somehow be expeditiously brought together, manifold opportunities for general benefit will remain unrealized. Interest problems reflect the tendency of people partial toward their own distinctive ends to bend the rules that govern social interaction. Thus coercive enforcement mechanisms are necessary, but because agents of enforcement are themselves morally and epistemically fallible, we confront the problem of vindicating the rights of those who have suffered encroachments while minimizing episodes of misdirected punishment. Which form of social organization best addresses this triad? In this important contribution to legal and political theory, Barnett argues that it is the classical liberal prescription of robust private property rights coupled with extensive liberties promoted and protected under the rule of law. Much in The Structure of Liberty will seem familiar. The discussion of dispersed knowledge clearly is indebted to Hayek and the Austrian economics tradition, and many of the strands of Barnett's analysis of the partiality problem are already present in the individualist tradition running from Hobbes and Locke through Hume and Smith. Barnett casts his argument within a framework of natural law understood as hypothetical imperatives of rational prudence, but he is not overly concerned with how best to sketch the deep theory of morality just so long as whichever starting point may be adopted renders plausible the ascription to individuals of basic liberal rights. Working out intermediate consequences is the book's major labor. In a brief review it is not possible to convey the richness and complexity of the discussion, so I restrict attention to three of its more distinctive components: the argument for the inalienability of individuals' right to liberty; Barnett's restitution theory of punishment; the case for decentralization of law adjudication and enforcement. It should be noted, though, that much of the value of the book lies in the manner in which these threads interweave with more standard elements of the liberal discussion. The result is one of the most important contributions to the case for libertarianism since Nozick's Anarchy, State and Utopia (1974). A persistent bone in the throat of classical liberalism is whether individuals can voluntarily enter into slavery contracts, thereby exercising their liberty so as to annihilate it. Although not exactly a burning issue within political practice, theorists have taken it to be an important test of the coherence of an order in which persons' liberties are constrained only by the like liberties of others. If slavery contracts are permissible, then it is conceivable that one person would come to own everyone else—hardly a result that liberals will be pleased to endorse. On the other hand, if liberty may be restricted so as to avoid this odious result, then there seems to be no bar in principle to limiting liberty so as to avoid other kinds of unpalatable outcomes. The voluntary slavery puzzle has, therefore,


We study the behavior near x0 of any positive solution of (E) −�u = u q in Ω which vanishes on ∂Ω \{ x0} ,w hereΩ ⊂ R N is a smooth domain, q (N + 1)/(N − 1) and x0 ∈ ∂Ω. Our results are based upon a priori estimates of solutions of (E) and existence, non-existence and uniqueness results for solutions of some nonlinear elliptic equations on the upper-half unit sphere. To cite this


Ceanothus is composed of ca. 50 species and is distributed throughout much of North America. The highest diversity is found within the California Floristic Province, including 22 of the 29 species of subgenus Ceanothus and 20 of the 21 species in subgenus Cerastes. Ceanothus has a reputation as being "difficult", owing to the inability to identify some specimens unambiguously and to discriminate adequately between closely related taxa. Surprisingly, if one compares taxonomic treatments over the past 125 years, one finds a high level of consensus among such authors as William Trelease, Sereno Watson, Katherine Brandegee, and Howard McMinn. What then contributes to the difficulty in recognition? Most species of Ceanothus are characterized by a combination of life form, leaf arrangement and morphology, flower color, and fruit morphology. For most species, unambiguous recognition depends on having all of these features available. However, most specimens, whether living or dead, do not provide all this material at the same time. Both primary and secondary intergradation also contribute significantly to local and geographic patterns of variation. Molecular studies have, in some cases, provided significant insight into evolutionary patterns, but have not necessarily enhanced the ability to refine "circumscriptions" of particular taxa. In fact, such studies may be pointing toward morphological convergence among some lineages. The consequence may be elucidation of a remarkable evolutionary diversification combined with further exasperation in the process of identification.


The article contains analytical data obtained as a result of field research, scientific literature and analytical work carried out in the Andijan provincial prisoner-of-war camps in Uzbekistan and near the town of Bekabad, archival documents on conditions and internal regulations, sanitary and hygienic environment, types of economic activities in the camps, the work of prisoners of war, their memories and the kindness of the Uzbek people to them are studied and discussed.


In this work we study the effect of influence of the superlattice of electron density on the light propagation in the ferromagnetic semiconductors (FMSC). It is shown that as a result of incident electromagnetic wave diffraction by the superlattice of electron density there appear two waves in which a periodic transfer of energy from one wave to another. It is shown that on the base of FMSC with superlattice will be developing a diffraction elements for optical drives.


The ability to analyse transverse slots in inhomogeneously loaded rectangular waveguide creates new design possibilities for slotted waveguide arrays. In order to demonstrate some of these advantages, this paper presents results which show that transverse slot arrays in inhomogeneous rectangular waveguide can be designed which do not have grating lobes in their radiation patterns, and do not suffer from the same distribution taper limitations as similar arrays of homogeneous waveguide transverse slots. The self-properties of individual transverse slots in inhomogeneously loaded rectangular waveguide are computed with a moment method code and compared to measured data. Design equations with which the length and offset of each slot in a resonant linear array may be calculated, were derived. The design procedure includes the effect of external mutual coupling.


Objective: The aim of this study was to compare the incidence of subclinical organ complications between hypertensive men and women. Design and method: A total of 82 hypertensive patients (41% women, n = 34) without known history of diabetes and coronary artery disease, were evaluated irrespectively of prior treatment with transthoracic echocardiography (TTE) and biochemical tests. TTE evaluation consisted of the assessment of left ventricle hypertrophy (LVH), left ventricle systolic and diastolic function (evaluated respectively as left ventricle ejection fraction (EF) and E/E'). Laboratory testing included serum creatinine level, microalbuminuria and urine albumine/creatinine ratio (ACR). Results: The mean age was significantly lower in the men group (43 vs 61 years old, p < 0,001), despite no significant difference in hypertension duration in each group (3 vs 5 years, p < 0,174). Despite lower incidence of LVH in men (26,1% vs 51,5%, p = 0,032), significantly lower values of E/E' and EF were observed in this group (7,5 vs 10,0, p = 0,003; 63% vs 65%, p = 0,025). Laboratory findings showed no difference in ACR (0,005 for both men and women), however microalbuminuria and serum creatinine were higher in men (0,69 vs 0,4; p = 0,002; 0,9 mg/dl vs 0,7 mg/dl; p < 0,001). Conclusions: The study results suggest that hypertensive men despite relatively lower age and LVH incidence are more susceptible to develop systolic and diastolic dysfunction as well as renal complication.


Programmers spend a significant proportion of their time searching for and making sense of complex information. However, they often lack effective tools to help them make sense of the information, turn it into knowledge, or share it with their respective communities. In this position paper, we aim to help programmers collect, navigate, and organize knowledge to meet their goals while capturing this knowledge and making it useful for later programmers with similar needs. We describe barriers and challenges to creating this sustainable cycle, and we explore the design space and opportunities for effective tools and systems.


About the Authors. Preface. Acknowledgements. Part I Introduction. Chapter 1 Introduction to Group Practice. Part II Developing Group Skills. Chapter 2 Fundamentals of Group Work. Chapter 3 Understanding Group Development. Chapter 4 Theory and Practice of Group Work. Part III Developing Agency Skills. Chapter 5 Understanding Agency Systems and Diverse Client Populations. Chapter 6 Ethical and Legal Issues of Group Work in Agency Settings. Chapter 7 How to Engage in Successful Group Practice within an Agency. Part IV Applying Group and Agency Skills. Chapter 8 Application of Skills: A Lifespan Approach. References. Author Index. Subject Index. About the CD-ROM.


The aim of this study is to clarify whether personal values explain delinquents' and non-delinquents' general attitudes towards legal norms. We expect that 10 basic personal values form a circular scale common to all individuals, both delinquents and non-delinquents, that people's ratings of the importance of these 10 values predict their norm acceptance in a sinusoidal way, with higher predictability for delinquents, and that the correlations of personal values with norm acceptance are highest for those delinquents with a broad spectrum of offences. Finally, we expect that gender does not have an impact on these profiles, whereas controlling for age does. Our analyses are based on four studies on community crime prevention. The results are in line with the above expectations.


A study of Markov characteristics for simplifying the model of high frequency channel is presented aiming at the problem of the randomly time-varying tap which is difficult to estimate.By partitioning the continuous-value channel gain into a finite number of states are modeled as a first-order Finite-state Markov(FSM) chain.The parameters of the FSM model such as stationary probability and transition probability are calculated with the given fading characteristic parameters.It analyzes the average error probability and the characteristics of state duration for the FSM model.The validity and accuracy of the model are confirmed by the simulation.


The purpose of this study was to develop neuroscience-based learning media at SMK Muhammadiyah 3 Yogyakarta. The research approach used in this research is research and development (R&D). The research subjects were teachers and students. Data collection was carried out by using interviews, observation, and documentation methods. The validity of this research data using triangulation. Data analysis used the Miles and Huberman model, namely data reduction, data display, and conclusion drawing/verification data. The results of this study prove that learning media is very effectively used to improve student learning outcomes. Based on the results, it can be concluded that the material brain-based learning media is considered very feasible to be applied in Arabic teaching and learning activities. In addition, this learning media is considered effective to be implemented in the process of learning Arabic mufrodat and muhadasah.
Keywords: Arabic; mufrodat; muhadasah; neuroscience; teaching media.


The performance of chaos-based DS-CDMA communication system over an m-distributed fading channel is evaluated. The chaos synchronization is assumed and a coherent reception in multi-user case is considered. Based on the Rician approximation of the energy distribution, an exact analytical expression of the bit error rate is derived. Many chaotic maps are used in order to demonstrate the exactitude of our analytical approach. Analytical and simulated results are presented and compared.


The purpose of this study is to develop a five-axis scanning touch probe with high precision and low contact force. The development of scanning touch probe is consisted of three parts: mechanism design, optical path design, and rotation structure design. The mechanism design contains three parts, Z-axis system, XY-axis system, and probe mechanism. The Z-axis system applies the characteristic of the thin sheet spring to move vertically. In the design of XY-axis system, a micro-beam is employed, through which length, width, and thickness of the micro-beam and corresponding dimensions of the leaf spring are designed according to the selected contact force. The freedom degree is limited to three. And the center of the mechanism is equipped with a stylus to inhibit displacement of the Z-axis. The contact between the probe and the work piece only leads to change in the angles of X- and Y-axes, achieving the feature of 2-degree freedom. To enable rapid change for the probes, this study designs a probe mechanism, reliability of which is analyzed and validated with ANSYS software, so that the design of 3-degree freedom mechanism is completed. The sensor has a laser diode to coordinate with Position Sensor Detector (PSD) which works with the optical path designed to measure placement of Z-axis and angle placement of XY-axis. The rotation structure refers to the principle of 5-axis machining design, and the two rotary axes (A- and C-axis) to join the self-developed scanning probe. This design can achieve independent measurements and eliminate the dynamic measurement error that three-axis scanning systems typically have. By validation through an experiment, the three-dimensional scanning touch probe developed by this study has a measuring range of ±1mm×±1mm×1mm, and unidirectional repeatability of 0.6μm.


Map of North Korea Introduction PART I: Understanding the DPRK 1 Politics with North Korean Characteristics 2 The Role of History 3 Rise and Fall of the North Korean Economy 4 Society 5 Cultural Values 6 The Outside World PART II: Visiting and Living in the DPRK 7 Practical Aspects 8 The Land and its Sights PART III: A Brush with History 9 Opening the British Embassy Pyongyang, 2001-02 References/Bibliography Index


FIELD: engines. SUBSTANCE: invention may be used in internal combustion engines. Method of engine starting includes throttle (64) position installation based on of pressure in brakes booster (140). Estimating amount of air in engine cylinder and amount of fuel evaporation during start-up based on pressure in brakes booster (140). EFFECT: technical result consists in improvement of fuel-air mixture and reduced emission of combustion products with exhaust gases. 10 cl, 4 dwg


Abstract : This report documents a FORTRAN routine WOLFQP for solving quadratic programming problems. Theory, usage notes and examples are included in the report.


his life." This quality made Carver a leader. He had the uncanny ability to generate enthusiasm and to capture the support, even the veneration of his students and of others, black and white, who heard him speak. This came not from his skills as a bombastic orator but from the heartfelt beliefs that he could convey to his listeners. Thus the paradox: Carver became famous as a scientist, yet his scientific achievements were modest. Beyond this paradox lies another, one that makes Carver's life tragic. As McMurry notes, Carver's fame as a scientist arose because he was black. He became a symbol of the hard-working, modest black who by refusing to challenge jim crow institutions and other forms of race etiquette and by concentrating on his scientific pursuits became a great scientist. This view of his attitude towards black rights was itself a myth, for Carver, if he did not lead a direct political challenge to racism, devoted his life and his talents in an effort to improve the well-being of southern poor blacks. Indeed, his decision to forgo graduate training beyond the M.A. in order to take a position at Tuskegee where, as he wrote, he could fulfill "the one ideal of my life to be of the greatest good to the greatest number of 'my people' possible," and his decision to spend the remainder of his life at Tuskegee prevented him from becoming the real, innovative scientist that his native talents promised he could be. "If he had been white," McMurry explains, "he probably would have made significant contributions in mycology or hybridization and died in obscurity. Because he was black, he died famous, without making any significant scientific advances" (p. 305). Perhaps the final paradox and tragedy is that this man, so famous in his own time, in a time when blacks were almost completely absent in historical scholarship, now, in a time when the importance of black history from the black perspective is recognized as vital to our understanding of American history, is virtually ignored. Those who seek to understand in concrete terms what W. E. B. DuBois called the duality that splits the minds and hearts of American blacks and who seek to understand the complexities of racism and its effects would do well to read and ponder this splendid biography and the sources upon which it is based.


【Objective】 Embryogenic somaclone induced from immature embryos is of great importance in transgenic and traditional breeding of wheat due to its higher totipotency than that of other explants.However,decrease or loss in embryogeny of somaclone during subculture has prevented the further application of such clones.Therefore,the objective of present study is to explore the reason using POD activity measurement and histochemistry methods.【Method】 Histo-and bio-chemistry methods were employed to invstigate the changes of somaclone during subculture,and to compare the differences among embryogenic-(EC)and nonembryogenic calli(NEC),induced from twelve wheat cultivars(lines).【Result】 Compared to non-embryogenic calli(NEC),embryogenic calli(EC)expressed higher peroxidase activity(POD)than that of NEC.Under microscopy observation,cells of EC with small cellular volume,big nuclei and thick cytoplasm,arranged in order,while cells of NEC arranged loosely with big cellular volume,small or no nuclei and thin cytoplasm.Some cells in EC emerged as thickened cell walls and ingrowed,even aggregate to form embryoid or embryoid-like structures.In NEC,cells showed somewhat vacuolization tendency and parenchyma cells occupied most ratio.Also,lignified trachea appeared in NEC.During subculture,cells of embryogenic calli,derived from and represented by wheat cultivar Xiaoyan 22,aggregate to form embryoid or embryoid-like structures from the external or internal of calli.Also,there appeared ring vessels in embryogenic calli during subculture.For non-embryogenic calli,little or no embryogenic cells aggregation and embryoid can be observed during the course of subculture.【Conclusion】 Compared to NEC,cells in EC organized in better order and has higer POD activity and higher ratio of embryogenic cells.During the course of subculture,the decrease of embryogeny in EC was ascribed to the cell organization.


How to effectively protect the privacy of data, establish a data center platform and solve the problem of vulnerable deep learning has become an urgent problem to be solved. In particular, desensitization of data is an effective way to avoid data privacy disclosure. This study puts forward a new solution. Firstly, this article identifies the sensitive data, then extracts the sensitive data from the original data, constructs the desensitization technology library of the sensitive data, then desensitizes the sensitive data, and finally transfers the data to the model for training, so as to deliver the deep learning model for training without changing the original distribution of the data, it avoids the problem of privacy disclosure caused by model attack.


The African continent faces grave socio-ecological challenges: population growth, desertification, deforestation, and loss of biological diversity—especially wild animals and plants.1See, generally...


Abstract does not appear. First page follows.
 About a quarter of a century before virus diseases as such began to be recognized,
 evidence of graft transmission of a chlorosis of the rose was recorded in France (12)4. However, mosaic as a disease of importance in rose culture did not attract attention
 until about 1928 (14). Mosaic then for several years excited an unusual amount of comment and controversy
 (7),(8),(18) which has been only partially justified by more extensive observations and experiments
 (7), (13), (17). It is now apparent, at any rate, that the rose may be affected by virus diseases
 of some importance and may serve as a potential source of virus for other plants (10).
 The material presented in this paper relates to the mosaic type of disease only. The
 necrotic diseases reported from the eastern United States (2) and abroad (4), (5) have not been found in California.
 Symptoms
 As early as 1933, evidence began to appear in this work indicating that not one mosaic
 disease occurs among the cultivated roses but several. Since some of these were not
 recognized as distinct until recently, it will not be possible to treat them separately
 throughout this paper. For convenience these will be designated as "rose mosaic 1,"
 "rose mosaic 2," and "rose mosaic 3," and the corresponding viruses distinguished
 by their respective numbers.
 In roses grown out of doors, lime-induced chlorosis without malformation is rather
 common, notably in the Santa Clara Valley. In such cases the leaf blade becomes uniformly
 yellow rather than mottled. This may obscure or inhibit development of symptoms of
 the mosaic diseases and may in some cases be confused with them. Diagnosis in the
 field is also complicated very frequently by insect injury (7), particularly that produced by leafhoppers.
 Types of variegation are encountered occasionally, which appear to be entirely genetic
 in origin. Scions of one such rose (fig. 3, A) were grafted on Rosa odorata and kept under observation for several years.


Social networks are among the most popular interactive media today due to their simplicity and their ability to break down the barriers of community rules and their speed and because of the increasing pressures of work environments that make it more difficult for people to visit or call friends. There are many social networking products available and they are widely used for social interaction. As the amount of threading data is growing, producing analysis from this large volume of communications is becoming increasingly difficult for public and private organisations. One of the important applications of this work is to determine the trends in social networks that depend on identifying relationships between members of a community. This is not a trivial task as it has numerous challenges. Information shared between social members does not have a formal data structure but is transmitted in the form of texts, emoticons, and multimedia. The inspiration for addressing this area is that if a company is advertising a sports product, for example, it has a difficulty in identifying targeted samples of Arab people on social networks who are interested in sports. In order to accomplish this, an experiment oriented approach is adopted in this study. A goal for this company is to discover users who have been interacting with other users who have the same interests, so they can receive the same type of message or advertisement. This information will help a company to determine how to develop advertisements based on Arab people's interests. Examples of such work include the timely advertisement of the utilities that can be effectively marketed to increase the audience; for example, on the weekend days, the effective market approaches can yield considerable results in terms of increasing the sales and profits. In addition, finding an efficient way to recommend friends to a user based on interest similarity, celebrity degree, and online behaviour is of interest to social networks themselves. This problem is explored to establish and apply an efficient and easy way to classify a social network of Arab users based on their interests using available types of information, whether textual or nontextual, and to try to increase the accuracy of interest classification. Since most of the social networking is done from the mobiles nowadays, the efficient and reliable algorithm can help in developing a robust app that can perform the tweet classification on mobile phones.


The contribution of chemistry in engine fuel formulation : a survey of events from World War II to now Engine fuels are no more products coming from the distillation of crude oil. Their formulation requires chemical operations, namely transformation of different hydrocarbon chemical families, adding organic oxygenated compounds, using of various additives. A short story of engine gels is presented here with emphasis on different events where the contribution of chemistry was noticeable : - evolution of refining since 1930, - management of raw materials during and after the Second World War, - development and decline of lead alkyl additives, - growth of oxygenated gels market, - production of reformulated fuel-I in relation with environment protection criteria.


Perfluorinated compounds (PFCs), including sulfur hexafluoride (SF 6 ), are used as insulating gases for heavy electric equipment, and are green- house gases with a very high global warming potential. For the thermal decomposition of greenhouse gases, a high temperature of 3,000 K or more and a technology to prevent recombination of the decomposed gases are required. A direct current plasma arc with a flame temperature of 6,000 K or higher provides an effective ultra-high temperature for the decomposition of chemically stable PFCs. A large amount of CaO, which is a raw material for clinker, is in the cement kiln, hence the S and F radicals decomposed from SF 6 react with CaO to quickly convert it to CaF 2 and CaSO 4 and prevent their recombination. Therefore, the convergence technology of plasma and cement kiln is known as an effective method for treating PFCs. However, the interior of the cement kiln causes erosion of the plasma torch due to the turbulent flow of a large amount of combustion air at a high temperature of 1,500 ∘ C or more, and the scattering of the raw material particles of the clinker, which greatly affects the operation stability. In this study, a plasma torch was developed that can maintain stable plasma in a vulnerable environment and effectively decompose PFCs. Moreover, the design and results of the experiment on the torch were presented to enable stable plasma operation for a long time in vulnerable environmental conditions through durability, plasma efficiency, and analysis of the discharge characteristics. thermal efficiency, and durability of the plasma torch were analyzed. Continuous operation of the plasma torch for more than 1,000 h while maintaining the plasma characteristics even in en- vironments with a high temperature, vibration, and strong turbulent flow was verified using a molybdenum preserve nozzle. At this time, the plasma efficiency was measured as 79.1%, confirming the supe-rior durability and efficiency of the developed plasma torch to those of the conventional PFC treatment torch. These results show that the high-temperature plasma torch can be considered advanced technol- ogy with high utility in various waste gas treatment processes and plasma incineration fields by overcoming the short lifespan due to electrode erosion, which is a known disadvantage of high-temperature plasma torches.


The comparable figures theory is important for the development of new products and has a huge number of applications, especially in fluid mechanics it. For the technical mechanics it is not such popular as in fluid mechanics. This research is conducted to obtain an application of the comparable theory in the mechanics of solids. In this article the testing part will be discussed. There are many important factors to get good results with small measurement errors. The validation with real tests is always very important for later application of the comparable figure theory.


Recently there have been many debates about the issue of community of Northeast Asia actively for a few years but the relationship among three countries has yet to become intimate. The most definite and efficient way to get over this status is to understand others' culture and get intimate feeling with each other through interchanging emotion with some thing like as arts & culture. Thus there have been many discussions about exchanging arts & culture recently, but most of them are superficial. This study has examined and analyzed the status of te exchange of arts & culture among three countries positively on the base of accurate statistical data, pointed out the problems, and suggested an alternative proposal. First, when consulting the area of literature, Korean literature has few in the number as well as they are concentrated to the specific writers. And also their translations are concentrated to English, French, German, and Spanish because they are concerning the possibility of winning Nobel prize for literature. Second, in the area of performance art, even though there is a variation, there have been incessant exchanges in play and dance. However there is a limit in the sense that they are yet staying in the superficial exchange dimension without reaching the place where they can understand others' culture. In addition, when considering their relationship of music among them, the exchange of traditional music is rare. Third, the exchange of visual art is relatively fair in comparing two areas mentioned above, it can be seen positive. But this exchange is also focused on paintings so it needs to seek the plan for exchange among other genres. The reason why there exist problems in exchanging arts & culture is that Korea, China, and Japan have mainly received arts & culture from Western countries. Therefore the exchange of arts & culture is staying at the simple stage, literally, where they can not understand others' culture. It needs to research the issue on the identity of Northeast Asian area among three countries in dept through various kinds of symposiums to exchange arts & culture actively afterwards.


The invention relates to an intelligent home furnishing control system and realization method of the system. The intelligent home furnishing control system comprises an intelligent home furnishing controller, a remote control terminal, a WIFI (wireless fidelity) router, an appliance control sub-system, a home furnishing device control sub-system, a security alarm sub-system and a monitoring camera sub-system, wherein the appliance control sub-system comprises an infrared transponder, an intelligent switch and an intelligent socket; the security alarm sub-system comprises an infrared alarm probe, a door magnet alarm probe, a gas alarm probe and a fire alarm probe; and the home furnishing device control sub-system comprises an electric curtain controller, an electric curtain, an electric window opening controller, an electric window opener, and a energy-saving remote control break controller. The intelligent home furnishing control system further comprises a power line carrier alarm sub-system used for basements. The intelligent home furnishing control system has the advantages that the remote control modes are flexible and various, a user can control home furnishing at any time andhome furnishing alarm information can be sent to the user by a text messages mode at real time.


A method is proposed for finding decision boundaries, approximated by piecewise linear segments, for the classification of patterns in R 2, using an elitist model of a genetic algorithm. It involves the generation and placement of a set of lines (represented by strings) in the feature space that yields minimum misclassification. The effectiveness of the algorithm is demonstrated, for different parameter values, on both artificial data and speech data having non-linear class boundaries. Its comparison with the k-NN classifier is also made.


Developing doctor-patient relationships are key to avoiding oversimplification of characteristics like race and gender, which can result in stereotyping and medical mismanagement.


The electrical power produced by renewable energies can be chemically stored as hydrogen and other fuels via electrolysis. CO2 together with H2O can be used in this context as a feed in order to produce valuable chemical products, such as CO, CH4, C2H4, HCOO–, or CH3OH. This process will not only allow storing excess energy but also to close the CO2 cycle, i.e., recycling of this greenhouse gas. The main challenges of the CO2 reduction reaction (CO2RR) are related to reduce its overpotential, increasing overall faradaic efficiency and better control product selectivity. Different aspects are studied at PSI's Electrochemistry Laboratory: • development of analytical tools for online and operando detection of reaction products in the electrochemical reduction of CO2; • definition of the origin of selectivity for specific electrode materials; • design electrocatalyst systems with high selectivity in the CO2 reduction towards valuable products such as syngas, methanol or methane; • development of polymer electrolyte based electrochemical cell. In this report the focus is made on the development of polymer electrolyte electrochemical cells.


Small businesses may benefit from innovations in terms of structure, supply or markets, as producers of complementary products or in serving specialist niches. In addition, small firms may enjoy comparative advantage in industries that serve smaller, fragmented markets, where consumers value variety and where manufacturing flexibility carries a premium. This research highlights the present status of small and medium enterprises (SMEs) in Fiji and attempts to identify the strategies that help enhancing their competitiveness through innovation. Results of this study reveal that there is positive relationship between customer orientation and entrepreneurial activity and the correlation results are significant in explaining the linear association. The interesting result of this research shows that entrepreneurial growth in Fiji is not dependent on technological innovation.


The paper seeks to explore the risk factors associated with poor indoor environment and to examine the relationship between the poor indoor environment and the occurrence of related respiratory diseases using Karl Pearson's Correlation Coefficient. The study is based on primary sources of data collected with the help of well structured questionnaire from a sample of 1500 households belonging to different income groups. The main finding which has been drawn from this study is that 'poverty is the greatest polluter. The results substantiate that poor indoor environment contributes to respiratory diseases. The problems were more severe in the low and lower middle income households.


An apparently nonpathogenic herpesvirus of turkeys (HVT) (12) is considered safe and efficacious (8) to use as a vaccine for the protection of chickens against Marek's disease (MD). Most studies reported used cell-associated virus stored at -196 C with dimethyl sulfoxide as a preservative, and this type of vaccine is presently in use in many countries. Cell-free HVT also was shown effective (8), though its use was not considered practical until suitable methods for virus extraction and lyophilization were developed (2). Lyophilized vaccine is now being produced in Great Britain. In an earlier communication (9), we reported that chicks with maternal antibody against Marek's disease virus (MDV) were fully susceptible to cell-free HVT even though the two viruses are antigenically related (12). However, many chicks with homologous maternal antibody (from HVT-vaccinated dams) were resistant to vaccination at 1 day of age. A few chicks were still resistant at 2 weeks, but by 3 weeks of age all were fully susceptible to vaccination. Since HVT vaccine is generally applied soon after hatching, and since many breeding flocks have themselves been vaccinated with HVT, interference be maternal antibody is an important question. In our earlier study (9), the immune parent flock was vaccinated after the dams had reached sexual maturity (91/2 months old) and only one month prior to obtaining progeny for the experiments. It was considered possible that maternal antibody levels (and the vaccination interference problem) might be less, or even absent, if elapsed time after vaccination was longer or if the dams were vaccinated at 1 day old rather than at an older age. Also of interest was the question whether HVT maternal antibody could


Technical advances in 3D metrology bring the increasing availability of imaging data, which are critical to quality inspection and process improvement. Dealing with 3D imaging data has become a general problem facing both traditional and next-generation innovation practices in biotechnology. Traditional methodologies in statistical quality control focus on key characteristics of the product, and are limited in the ability to model spatiotemporal patterns in imaging streams. This paper presents a dynamic network methodology for monitoring and control of highdimensional imaging streams. The developed methodology is implemented and evaluated for process monitoring of living cells during the synthesis of bio-products. © 2017 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the scientific committee of the 3rd CIRP Conference on BioManufacturing 2017.


a r t i c l e i n f o Keywords: Blood oxygenation Cerebral blood flow Cerebral metabolism MRI TRUST With age, many aspects of the brain structure undergo a pronounced decline, yet individuals generally function well until advanced old age. There appear to be several compensatory mechanisms in brain aging, but their precise nature is not well characterized. Here we provide evidence that the brain of older adults expends more energy when compared to younger adults, as manifested by an age-related increase (P = 0.03) in cerebral metabolic rate of oxygen (CMRO 2) (N = 118, men = 56, ages 18 to 74). We further showed that, before the mean menopausal age of 51 years old, female and male groups have similar rates of CMRO 2 increase (P = 0.015) and there was no interaction between age and sex effects (P = 0.85). However, when using data from the entire age range, women have a slower rate of CMRO 2 change when compared to men (P b 0.001 for age × sex interaction term). Thus, menopause and estrogen level may have played a role in this sex difference. Our data also revealed a possible circadian rhythm of CMRO 2 in that brain metabolic rate is greater at noon than in the morning (P = 0.02). This study reveals a potential neurobiological mechanism for age-related compensation in brain function and also suggests a sex-difference in its temporal pattern. Introduction The human brain consumes about 20% of the total energy, although it only accounts for 2% of the total body weight (Attwell and Laughlin, 2001). In addition, most of the oxygen that brain consumes is used for neural activity (Buxton, 2002). Thus, the rate of oxygen consumption by the brain, referred to as cerebral metabolic rate of oxygen (CMRO 2), is an important index for neural activity. Regulation of brain metabolism is critical for the maintenance of normal cognitive function. In the context of brain aging, earlier studies showed that resting CMRO 2 were lower in older subjects (Aanerud et al., whereas activation data usually show that task-evoked fMRI signal (presumably reflecting task-evoked CMRO 2 changes) increases with age (Cabeza et al. which until recently was the only method to measure CMRO 2 in humans. Only a few of these had accompanying high-resolution (e.g. 1 mm 3) MRI image to allow careful delineation of regions of interest (Aanerud et al., …


Atrial fibrillation (AF) is the most common sustained supraventricular arrhythmia encountered in clinical practice. Due to the higher prevalence of rheumatic fever in several regions of India, rheumatic heart disease (RHD) is the most common etiological factor of AF.

 The objective of the study was to study clinical features, electrocardiographic (ECG) and echocardiographic (ECHO) findings, complications, and incidence of AF in rheumatic mitral valve disease (R-MVD).

 It is an observational cross-sectional study of 40 indoor patients in a Tertiary Care Hospital in Vadodara, Gujarat, carried over a period of a year. Clinical data including symptoms, signs, systemic examination, and relevant investigations were studied.

 67.5% (n = 27) of patients having AF were below the age of 50 years with higher incidence among females (72.50%) as compared to males (27.5%). Fifteen (37.5%) had mitral stenosis (MS) and 13 (32.5%) had MS with regurgitation. Most of the patients 35 (87.5%) presented with breathlessness, followed by palpitation 28 (70%). The most commonly heard murmur was mid-diastolic (65%, n = 26), followed by pansystolic murmur (40%, n = 16) at the apex. Out of 40 patients, 15 (37.5%) had evidence of left ventricular hypertrophy on ECG, whereas only 5 (12.5%) had right ventricular hypertrophy. Four out of five patients with the evidence of cardioembolic stroke had left atrium (LA) size >45 mm which suggests an increased risk of embolic stroke with increased LA size. Only 3 (7.5%) patients had a visible LA clot in LA on two-dimensional ECHO, whereas only one patient had vegetation on valves. Twenty-seven out of 30 patients treated with diltiazem show good response. Heart failure was the most common complication affecting 85% (n = 34) of the patients with AF with R-MVD. Four (10%) patients out of 40 expired including 1 (25%) of the four pregnant patients, suggesting higher mortality among pregnant females due to superimposed physiological changes occurring during pregnancy.

 In developing countries like India, RHD is a major cause of AF affecting the younger population and more commonly females. Most of the patients in our study presented with breathlessness and palpitation. LA size was directly proportional to the risk of cardioembolic stroke and most of the patients developed heart failure as a complication.


The increasing political attacks on the judiciary by both major political parties and by candidates for judicial office are diminishing the independence of the judiciary and, equally important, the public's confidence in it. Thus, the distinction between fair criticism of judges and intimidation of them is an important one.There is no question that fair criticism plays a critical role in improving the quality of the courts. Every appeal, every petition for rehearing, every dissent is a criticism of a judicial decision. Decisions like Dred Scott v. Sandford, Plessy v. Ferguson, and McCleskey v. Kemp should be criticized. Citizens should ask if these decisions were correct. What does the Constitution require? Should it be amended? If the case involved a matter of statutory interpretation, should Congress respond with legislation?It is equally clear that everyone in the United States has a First Amendment right to be a demagogue and to make irresponsible criticism. But irresponsible criticism which brings about the removal of judges from office or influences their decisions is incompatible with judicial independence and the rule of law. Courts have a duty to protect the rights of minorities - political, racial, ethnic - no matter how unpopular their rulings may be. Legislators or executives may base their decisions on focus groups or public opinion polls, but judges may not. Judges are expected to enforce the law, whether it be the First Amendment freedom of the radical right or the radical left to publish political views which may seem distasteful to some, the right of The New York Times to publish the Pentagon Papers or the right of a suspected child molester to a fair and impartial trial. As Edmund Burke put it, the judiciary is to serve as "safe asylum" during times of crisis. In the United States, courts are to uphold the Bill of Rights regardless of whether the decision is popular at the time.Courts are not independent when state judges are voted off the bench because of unpopular decisions by their courts and federal judges reverse decisions or resign from the bench after a barrage of criticism. We must find ways to protect the rule of law from the potential harms of irresponsible criticism of judges and judicial decisions.The first issue I will address is what constitutes fair criticism and what constitutes irresponsible demagoguery that threatens the independence of the judiciary. Second, I will examine the damage to the integrity, effectiveness, and credibility of the courts caused by irresponsible attacks. Third, I will propose ways in which political leaders, the Bar, and others who care about the integrity of the judiciary should respond to irresponsible behavior, such as President Clinton's and former Senator Dole's attacks on Judge Baer, 24 and measures that could be adopted to ensure that decisions are based on the law and not political pressures.


Recently, hybrid electric vehicles are required high power with high fuel efficiency and comfortable large cabin space. An ultra compact intelligent power module for two-motor hybrid electric vehicles which integrates one back-boost chopper and an inverter for a traction motor, an inverter for a power generator has been developed. The module is the world's first released module which has a direct liquid cooling structure with a solder-joined aluminium heat sink. The module achieves a 30-% reduction of volume and a 60-% reduction of weight compared to our conventional models. A heat sink with high cooling capacity and a high-strength solder were newly developed to establish the structure. The module is designed for 700 V/ 400 kVA system and it has an on-chip self protection functions and serial communication interface with a master control unit.


Background: The prediction of late distant recurrence (DR) is an important clinical goal for managing women with hormone receptor positive disease who have reached the end of 5 years9 endocrine treatment without recurrence. Molecular profiles have produced conflicting results for the prediction of late DR. Here, we develop and validate a simple clinicopathological tool (Clinical Treatment Score post-5 years (CTS5)) to estimate the residual risk of DR after 5 years9 endocrine treatment, which should help in discussions with patients about the potential benefits or not of continued endocrine therapy. Patients and Methods: The ATAC dataset (N=4735) of postmenopausal women with oestrogen receptor (ER) positive breast cancer treated with 5 years9 tamoxifen or anastrozole was used as a training cohort to establish a prognostic score for post-5-year risk of DR. CTS5 was based on five categories for nodal status, linear and quadratic terms for tumour size (capped at 30mm), three categories for grade, and continuous age. The validity of the CTS5 was tested in the BIG1-98 dataset (N=6711), which included postmenopausal women with ER-positive breast cancer treated with tamoxifen or letrozole (either monotherapy or sequential). Both cohorts included women who were alive and DR-free 5 years after randomization. Time to late DR, defined beginning at 5 years after ATAC or BIG 1-98 randomization, was the primary endpoint. Cox regression models estimated the prognostic performance of the CTS5. Hazard Ratios (HRs) are for a change of one Standard Deviation. Results: The CTS5 model was a significant predictor for late DR in ATAC (HR=2.47 (95% CI, 2.24-2.73), P 10% risk), identified 43% of the validation cohort as low risk, with an observed DR rate of 3.6% (95% CI 2.7-4.9) during years 5-10. Within nodal subgroups, 63% of node-negative were low risk with 3.9% (2.9-5.3) DR rate between years 5-10, and 24% having 1-3 nodes positive were low risk with 1.5% (0.5-3.8) DR rate between years 5-10. Separation of intermediate-risk from high-risk categories was also shown in the training set but improvements in calibration seem necessary for clinical utility for that assessment. Conclusion: The CTS5 is a simple tool based on information that is readily available to all clinicians. It was more accurate in its prediction of DR risk in years 5-10 than the published CTS model. CTS5 was validated as highly prognostic for late DR in the independent BIG 1-98 study. The algorithm identified a subgroup of women with either node-negative disease or 1-3 positive nodes as having less than 1% per year risk of DR who could be advised of the limited value of extended endocrine therapy. Citation Format: Sestak I, Regan M, Dodson A, Viale G, Thurlimann B, Colleoni M, Cuzick J, Dowsett M. Integration of clinical variables for the prediction of late distant recurrence in patients with oestrogen receptor positive breast cancer treated with 5 years of endocrine therapy [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr GS6-01.


To solve the cut - in fracture of insertion, according to the theroy of machining of metals, this paper researches into the first contact state of cutter tooth in the face - milling process based on the M. Kronenoberg touch method and LinShuXing geometry resolution method, and deduce nine contact state estimation expressionses,which solves the account problem of the insert entrance style. At the same time, it offers basis for optimizing the entrance style and studying the relationship between the entrance style and the insertion disrepair.


Women's spirituality in New Spain needs broader and better exploration. The writings of nuns, which have remained largely ignored and unpublished, should serve as a privileged medium for such purpose. In this work are introduced and analyzed some elements of such writing, using the monthly installments of a nun of San Juan de la Penitencia convent to her confessor (1758). This article surveys the landscape of the soul; the relation of the nun, as a writer, with her confessor; and the visions that enabled her to speak with her own voice as the recipient of God's message.