This work presents a comprehensive model that predicts sessile SRB concentration, sessile SRB growth-induced pitting corrosion rate, biofilm thickness, and SRB biofilm density and detachment density. The model can be employed to predict the above mentioned key parameters in liquid transporting and storage facilities prone to corrosion. Four pipelines (PL-1, PL-2, PL-3, and PL-4) selected from four production oilfields, one from each field, were utilized to perform computer simulations. The predicted pitting corrosion rates were proportional to the sessile SRB concentrations, and were highly influenced by the liquid flow velocities. Variations in biofilm thickness were proportional to the SRB biofilm densities. The detached biofilm density increased at relatively higher liquid flow velocities, which in turn decreased the biofilm thickness. PL-1 presented the highest corrosion rate (18.5 mpy) due to its low flow velocity (0.07 m/s) and high sessile SRB concentration (100,000 SRB /mL). The predicted sessile SRB concentration and sessile SRB induced pitting corrosion rate in PL-2 were 10,000 SRB/mL and 2.6 mpy, respectively. The pitting corrosion rate for PL-3 and PL-4 were predicted to be 0.43 mpy and 0.00025 mpy, respectively with corresponding sessile SRB densities of 1,000 SRB/mL and < 10 SRB/mL.


(2008) EMU in the car: evaluating multimodal usability of a satellite navigation system. In N. Abstract. The design and evaluation of multimodal systems has traditionally been a craft skill. There are some well established heuristics, guidelines and frameworks for assessing multimodal interactions, but no established methodologies that focus on the design of the interaction between user and system in context. In this paper, we present EMU, a systematic evaluation methodology for reasoning about the usability of an interactive system in terms of the modalities of interaction. We illustrate its application using an example of in-car navigation. EMU fills a niche in the repertoire of analytical evaluation approaches by focusing on the quality of interaction in terms of the modalities of interaction, how modalities are integrated, and where there may be interaction breakdowns due to modality clashes, synchronisation difficulties or distractions.


The present invention provides a method of using hot filament chemical vapor deposition (HWCVD) process of the deposited film. In some embodiments, the method includes providing a tool operating HWCVD hydrogen (H2) to the filament, after the first period, the filament in a processing chamber HWCVD tool; and a first time period elapsed after the current through the filament to the filament temperature is increased to the first temperature.


Cancer chemotherapy relies on the expectation that anticancer drugs will preferentially kill rapidly dividing tumor cells rather than normal cells. As a large portion of the tumor cells must be killed to obtain and maintain a complete remission, large drugs doses are typically used, with significant toxicity toward proliferating nonmalignant cells. Indeed, the majority of pharmacological approaches for the treatment of solid tumors suffers from poor selectivity, thus limiting dose escalation (that is, the doses of drug required to kill tumor cells cause unacceptable toxicities to normal tissues). The development of more selective anticancer drugs with an improved ability to discriminate between tumor cells and normal cells is possibly the most important goal of modern anticancer research. For this reason, there is much current interest in the development of new cytotoxic chemical entities with improved selectivity toward tumor cells and lower systemic toxicity. A highly promising strategy is based on the discovery that many tumors overexpress specific protein markers at the site of neoplasia, suggesting the possibility of implementing a ligand-based selective targeted delivery of drugs to the cancer cells and/or the tumor stroma. Indeed, a tumor-associated antigen can often be targeted by a monoclonal antibody (mAb) with suitable affinity and specificity. The pharmacokinetic properties of mAbs can be modulated by the choice of the recombinant antibody format, which ranges from the small scFv antibody fragments (which typically exhibit 90% clearance from the circulatory system within 1 hour) to the full immunoglobulins IgG (which display a half-life of weeks for the beta phase of blood clearance). Furthermore, mAbs and their fragments can be engineered to carry functional groups suitable for chemical modification such as C-terminal cysteine residues for selective coupling with thiol-reactive compounds. These features make mAbs excellent vehicles for the targeted delivery of cytotoxic drugs to the tumor in the form of an antibody–drug conjugate, whereas mAbs themselves are often only weakly cytotoxic and therefore not therapeutically useful. Mylotarg (Wyeth) is the first example of a recently approved mAb–cytotoxic drug conjugate for cancer therapy. Considering the difference in molecular weight between antibodies and cytotoxic molecules, and the fact that the injection of large quantities of antibody (>100 mg) into patients is not desirable for cost-of-goods considerations, it is intuitive to see that ideal drugs for targeted delivery applications should be capable of killing cells in the sub-nanomolar concentration range and should carry suitable functional groups for coupling to antibody molecules. Such highly potent drugs may allow the use not only of internalizing antibodies, but also of antibodies directed against the more abundant and stable stromal antigens, provided that a suitable hydrolytic mechanism is available for the liberation of the drug at the tumor site. Maytansanoids, auristatins, taxanes, epothilones, and other highly potent natural compounds have attracted considerable interest in this respect. However, the recent discovery of tubulysins by Hçfle, Reichenbach, and co-workers at the Helmholtz research center GBF (Braunschweig, Germany) generated the unprecedented hope of finally having a sufficiently powerful weapon in hand that allows full exploitation of the spectacular selectivity of mAbs. Recently, the German biotechnology company Morphochem and GBF set up a cooperation agreement with the objective to develop new therapeutics against cancer by using tubulysins. Tubulysins (Figure 1) are a family of tetrapeptides produced in rather small quantity (<4 mgL 1 culture broth) by two different species of myxobacteria: Archangium gephyra and Angiococcus disciformis. The structure, stereochemistry, and biosynthetic pathway of tubulysins were recently determined by Hçfle, Reichenbach, and co-workers, who also reported the potent cytotoxic activity (in the nanomolar concentration range) of these compounds. The cytotoxic activity of tubulysins stems from their ability to bind tubulin and disintegrate microtubules of dividing cells, thus inducing apoptosis. As cancer cells show high cell-division rates, this property of tubulysins could be used to selectively target cancer cells, although their extremely high toxicity renders unlikely the therapeutic use of tubulysins alone.


Abstract : In this report the design and application of the circuits used to interface a Lockhead SUE mini-computer with a Canoga Antenna Tracking System are described. Basic material on the theory and application of the antenna tracking system is also presented. (Author)


The utility model relates to a valve suitable for various pipelines, in particular to a fixed ball valve. The fixed ball valve comprises a worm gear assembling component, a valve body, a valve cover, a ball body and a sealing ring. The ball body is arranged in the valve body with sealing by the valve cover, the ball body is axially connected on the valve body by an upper valve rod and a lower valve rod. The worm gear assembling component is arranged above the upper valve rod by a sealing pressing cover and a support bracket. The sealing ring is movably arranged on the periphery of the ball body. The outer side of the sealing ring is arranged with a valve base closely to the periphery of the ball body and an o-shaped sealing ring is arranged above the valve body and the outer side of the valve base is arranged with a spring. The outer portion of the sealing ring of the utility model is arranged with the sealing valve base, the O-shaped sealing ring and the spring device to compensate the ordinary abrasion of the sealing ring to improve the sealing performance and the service life of the ball valve. The sealing ring is movable and thus the repair is convenient with easy disassembling and changing. The driving force of the worm gear driving device is powerful and the starting and the stopping are convenient and flexible.


Testability demonstration plays an important role in assuring the testability capability, which can decrease the fault diagnosis time and accelerate the maintenance actions. However, testability demonstration test with classical planning method has the problems of large fault sample size, high test cost, and long test period. A new testability demonstration planning method is proposed, which takes the component level data from both virtual and physical demonstration tests as prior information. Owing to the limitations of the testability modeling technology and relevant programming tools, the virtual testability prototype of the system level cannot be established and the virtual testability test data is not totally credible. So a data conversion method based on the information entropy theory is proposed to convert the component level virtual and physical test data into equivalent system test data, in which the data credibility is taken into consideration. The equivalent system test data is then used to get the prior probability density function of the testability indexes with an empirical Bayesian method. Then, a testability demonstration planning method of Bayesian posterior risk criteria is presented. Finally, the fault detection rate demonstration tests of a flight control system and a heating controller are taken as examples to verify the proposed method. The results show that the introduction of prior test data can effectively decrease the sample size and the credibility of the virtual testability test data can affect the test plan.


We experimented with the effect of oleic acid and its appropriate concentration to prevent powdery mildew eco-friendly in a cucumber greenhouse cultivation. 'Baekbongdadaki' (Nongwoo Bio. co. Korea) was treated in the plastic greenhouse at Sangmyung University. We treated four levels of concentration of oleic acid, which were 0, 2000, 4000, 6000, and 8000 ppm. There were investigated diseased severity, diseased leaf area, control value, and pesticide injury. The degree of control values by oleic acid treatments was investigated at 3 days after treatment. The recurrence of powdery mildew was checked for 55 days. The day and night temperature in the greenhouse were controlled to 23 and 15℃ respectively. The humidity inside the greenhouse was not controlled to prevent outbreak of the disease. From the experimental results, oleic acid was very efficient to control powdery mildew. 2000 ppm of oleic acid was shown to be the most control efficiency without any pesticide injury. The recommended method to treat it was to spray three times every 3 weeks.


Accurate testing requirement of communication and rational allocation of testing resources and efficient maintenance of test cases are very important in software testing process.Business rules and software scenes are integrated into the business model that will be used in the software testing process.Simultaneously,the methods generating test cases and ascertaining the order of implementing test cases based on business rules model are introduced.Finally,the business model is applied to the actual software testing project to prove that model is practicable and effective.


A model is developed and tested by implementing a program to identify problem parts. The model computes sustainability ranking number for parts of a system such as an aircraft. The ranking is defined as a function on a set of critical variables spanning a multidimensional space. Test values of the variables are extracted from different databases. Principal Component Analysis is used to reduce the data dimension. The ranking is obtained as a linear combination of the original variables. The sustainability ranking computed by the program is useful as a forecasting tool and critical part identification for part managers as a component of a decision support system.


"jiyi"(及以) is a paratactic conjunction that is only used in sutras.It first appeared in the translated Buddhist sutras in the Wei Dynasty.The word "jiyi"(及以)mostly joins nouns or noun phrases.Sometimes it joints two verbs or adjectives.It can be used with other paratactic conjunctions such as "ji"(及) "bing"(并)"yu"(与).The rhythm of Chinese "jiyi"(及以)is probably the causation of its appearance,which is produced based on the singular syllable word "ji"(及).


Recent years number of influences on the information environment of the states has been increased by non-military methods, which is due to the high level of development of information technologies and social engineering. Information and psychological influences become extremely widespread, as evidenced by the publications of the advanced countries where information security issues are discussed in the context of information and psychological influences. The main areas that become the goals of such influences are economic, military, political, and the means through which they are implemented, mainly media, social networks. Obviously, for effective counteraction, timely identification and identification of the impact is necessary. However, an equally important task is to clearly and accurately assess possible destructive effects, which leads to informational and psychological interference. There have been described the processes of information confrontation in the aspect of its psychological component. The developed method can be used in information and psychological security, in particular to prevent information and psychological influence on the individual and social group, effective implementation of countermeasures. The method of evaluation of informational and psychological influences and the corresponding structural solution of the system of evaluation of information and psychological influences, which, by processing fuzzy identifying parameters, allows us to assess the destructive effect of informational and psychological influences and create such systems for fuzzy environment.


The cross-sectional form and stability of large hydraulic fractures are found to be very sensitive to symmetric gradients in fluid pressure and regional stress. Horizontal sections through vertical fractures may be subjected to symmetric pressure gradients by locating inflow and outflow wells near the fracture center and tips. A dumbbell form, resulting from flow from the tips toward the center, has a limital length beyond which the fracture closes at the center and propagates unstably at the tips. A diamond form, resulting from the opposite sense of flow, has no limital length and a stable propagation. These features of fracture form and stability may play an important role in the design of hydraulic fractures for geothermal energy production. (AIP)


The objective was to prepare scandium oxide layers on tungsten for the surface study of Sc-O/W(100) emitters using two design types of a compact evaporator for Sc 2 O 3 and for metallic scandium deposition. Both of these evaporators were compatible with ultrahigh vacuum operation in a specimen chamber optimized for surface analytical measurements. The Sc 2 O 3 evaporator allowed Sc 2 O 3 to be deposited on a substrate while maintaining its stoichiometric composition. It was also demonstrated that scandium oxide layers could be prepared effectively on a substrate by deposition of metallic scandium followed by oxygen exposure.


Special optical equipment has been evolved to enable viewing of operations and study of materials in hot-cell laboratories. A description is given of the characteristics of various remote viewing systems, and it is explained how systems can be adapted to various uses and how the effects of radiation on the apparatus can be mitigated. (auth)


In high-frequency resonant converters, current transformers (CTs) are commonly used to measure the currents of the resonant tank for protection, feedback control, synchronous drive, etc. However, CTs may generate large power losses when measuring high-frequency large currents, which makes it difficult to miniaturize. This letter proposed an alternative isolated current sensing method. The method uses a transformer and a resistor to compensate the resonant capacitor to obtain the current flowing through the capacitor. Compared with the CTs, the proposed method can be much smaller and more efficient, because the current flowing through the transformer is significantly reduced. In the experiments, the transformer size of the proposed method is only 1/7 of that of the CT. The transformer temperature in the proposed method is only 54.7 °C, while that in the CT is as high as 116 °C when simultaneously measuring a 1 MHz, 12.5 A current. Besides, the experimental results show that the proposed method has good linearity and wide bandwidth.


An assessment of the economic qualities of lifting-and-transport machines is presented on the example of a swing-ing cylinder mechanism with hydraulic drive. The ideal-ized acceleration - braking cycle is considered, which allows to evaluate the parameters of the machine under the most unfavorable operating conditions. It is shown that an assessment of economic efficiency can be obtained by solv-ing a number of sequential tasks, an example of their calculation is given. It is concluded that the method of reducing energy consumption by changing the moment of switching from acceleration to braking in a lifting-and-transport machine is efficient and does not increase the structure cost. The estimation of the efficiency of the lifting-and-transport machine is given, recommendations are given on increasing the cyclic efficiency of the lifting mechanism. Thus, the methodology for controlling the moment of switching from acceleration to braking can be used in the design and calculation of the mechanisms of lifting-and-transport machines.


This case report evaluates the management of severely proclined maxillary dentition in a female patient having Class II malocclusion with lateral tongue thrust and multiple over-retained deciduous teeth. The case required extraction of maxillary 1 st premolars for correction of the proclined and forwardly placed upper front teeth and was corrected with Pre-adjusted Edgewise bracket system. Clinical and cephalometric evaluation revealed skeletal Class II malocclusion with maxillary anterior proclination and an orthognathic facial profile, an average to vertical growth pattern, potentially incompetent lips, an increased overjet and overbite. Following fixed orthodontic treatment by removal of 1 st premolars in the upper arch with retraction of anterior segment, a marked improvement in patient's smile, facial profile and occlusion was achieved and there was a remarkable increase in the patient's confidence and quality of life. The profile changes and treatment results were demonstrated with proper case selection and good patient cooperation with fixed appliance therapy.


The present invention relates to an embossed holographic graphics printing method, comprising the substrate coated with the coating to transfer hologram with UV UV lamp (33) is a holographic printing apparatus (. 3), the UV holographic printing material holographic graphics printed on the coating, while the UV-irradiated ultraviolet curing coating holographic series of steps, the series of steps, said printing means (3) comprises an impression cylinder (31), a water-cooled roller (32 ), holographic film unwinding means (34) and winding means (35), said UV lamp (33) disposed on the outside of the water cooling drum (32); in the embodiment of the series of steps further includes the following steps: a. the embossed holographic film (8) is attached to the holographic film unwinding means (34) and winding means (35), B. coated with a UV coating substrates with a hologram embossed holographic film (8) in close contact together, and then irradiated with a UV lamp (33) and a one-time cure. Advantage of the present invention is that: the embossed hologram film running speed printing, high production efficiency.


Implementing brand strategy to construct renowned tertiary schools is the inevitable choice for Chinese colleges and universities to meet the challenges from internationalization of educational trends,diversification of educational systems and popularization of educational scales.For the purpose of building prestigious universities,we should establish a brand concept,fix a clear position,highlight the school characteristics,improve the educational quality,and pay great attention to the culture on campus.


Objective To study the prognostic value of J-T peak (JTp interval) and late T peak width (T peak-to-T end interval, TpTe interval) to ventricular arrhythmia through surface electrocardiogram. Methods 289 patients with different cardiac diseases were selected. From them those with frequent ventricular premature beat ( VPB≥30 beats/hour) or ventricular tachycardia (VT) or ventricular fibrillation (VF) were assigned into Group VPB (n=69) or Group VT+VF (n=62) respectively, other 60 patients without evident ventricular arrhythmia (VPB5 beats/hour) were chosen to serve as disease controlled group ( Group D), and a normal controlled group was also set (Group N, n= 60). JTp, corrected JTp (JTpc) , and TpTe and corrected TpTe (TpTec) intervals were compared among the four groups. The ranges of JTp and JTpc intervals, TpTe and TpTec intervals in all patients were divided into several time intervals every 10 ms and every 5 ms respectively, the numbers of subjects and incidences of frequent VPB and VT+VF in each time interval were calculated,and the correlations between the morbidities of ventricular arrhythmia and the four indexes were studied. Results JTp and JTpc intervals in Group VPB and Group VT+VF were significantly longer than those in Group N (P0.05), but were not significantly longer than those in Group D. TpTe and TpTec intervals in Group VPB and Group VT+VF were not only longer than those in Group N, but also longer than those in Group D (P0.05). ②There were no significant correlations between incidences of ventricular arrhythmia and JTp and JTpc intervals, but positively significant correlations between incidences of ventricular arrhythmia and TpTe and TpTec intervals(VPB:r=0.6 649 and 0.6 658, P0.05;VT+VF: r=0.6 977 and 0.6 886, P0.05). Conclusions JTp and JTpc intervals have no prognostic values for incidence of ventricular arrhythmia while TpTe and TpTec intervals may serve as predictive electrocardiographic indexes of ventricular arrhythmia.


The present invention relates to a connector on the shaft (12) and the hub (10), wherein the hub (10) comprising a said shaft (12) of a respective seam sections (26, 30) connected a seam section (18) and a second seam section (20). Said shaft (12) and said hub (10) at a contact portion in the region of the first joint section (18) against each other, wherein the second seam section (20, 30) remains does not contact; against each other by a shaft (12) and the hub (10) of said contact portion (32, 34) conducting the welding current, so that the contact portion melts. In the first joint section (18, 26) the shaft (12) upon melting pressed into the hub (10) substantially until said second seam section (20, 30) between the until the surface form a nip.


Electronic tagging would be unnecessary if there were more nurses and care assistants in care homes (features April 23). It would also be unnecessary in homes that have coded entry and exit to their outside doors and gates. However most homes cannot afford to employ extra staff or install expensive security equipment.


The prevalence of chronic obstructive pulmonary disease (COPD) is rising faster in women in some countries. An observational time trends study was performed to assess the evolution of hospital admissions for COPD in men and women in Spain from 1998 to 2018. ICD-9 diagnostic codes (490–492, 496) from the minimum basic data set of hospital discharges were used. Age-standardised admission rates were calculated using the European Standard Population. Joinpoint regression models were fitted to estimate the annual percent change (APC). In 2018, the age-standardised admission rate per 100,000 population/year for COPD was five times higher in men (384.8, 95% CI: 381.7, 387.9) than in women (78.6, 95% CI: 77.4, 79.9). The average annual percent change (AAPC) was negative over the whole study period in men (−1.7%/year, 95% CI: −3.1, −0.2) but positive from 2010 to 2018 (1.1%/year, 95% CI: −0.8, 2.9). In women, the APC was −6.0% (95%CI: −7.1, −4.9) from 1998 to 2010, but the trend reversed direction in the 2010–2018 period (7.8%/year, 95% CI: 5.5, 10.2). Thus, admission rates for COPD decreased from 1998 to 2010 in both men and women but started rising again until 2018, modestly in men and sharply in women.


As a generalization of crisp topology, neutrosophic crisp topology was introduced. As a progression, binary neutrosophic crisp sets were introduced in this article and their properties were also studied. With the idea that neutrosophic crisp points forms the basis for the neutrosophic neighborhood structures, new points namely binary neutrosophic crisp points were introduced in this article. Owing to the new points, binary neutrosophic neighborhood structure in the new space named as binary neutrosophic crisp topological space is framed. Eventually properties of binary neutrosophic crisp neighborhoods were discussed.


NeuroElectrlc therapy (NET) is a 10-day treatment with a tranalatorlzed stimulator, which rapidly reduces both acute and chronic withdrawal symptomatology of all chemical substances, without drugs and with no negative side-effects. It is hypothesised that NET acts by specific electrical frequency stimulation of endorphin production that has been decreased due to chronic substance abuse. This has bean demonstrated using NET in rat models; cortlcosterone levels and hepatic enzyme activity were also significantly altered. of 186 patients, 98.4Z were successfully detoxified, with marked feeling of well-being and no craving (in 95Z) or anxiety (in 75X). Detailed assessments of abstinence syndrome in NET are given. of a 50Z response to follow-up, 78.SX were addiction-free (80.31 of drug addicts) 1 to 8 years after NET, although average time In rehabilitation was only 16 days. Alcohol, marijuana and cigarette use were decreased in 64Z. Diminished substance use was reported in 76X of recidivists.


A study is made of features of the ultrasonic shadow inspection of rigid foam plastics. It is shown that foam plastics are very complex objects from a testing standpoint due to the high degree of nonuniformity of the structure, which is in turn related to certain features of the processes of foaming and curing of the polymers. A comparative analysis showed that the amplitude-time method has an advantage over other shadow methods for the inspection of structurally nonuniform materials, since the amplitude corresponding to rejection is not the same for all foam plastics but is instead a function of the time parameter. It is established that defects in foam plastics should be regarded as acoustically translucent. Consideration of this factor makes it possible to judge both the length and the thickness of defects.


Evaluating landing technique using a computer simulation model of a gymnast and landing mat could be a useful tool when attempting to assess injury risk. The aims of this study are: to investigate whether a subject-specific torque-driven or a subject-specific muscle-driven model of a gymnast is better at matching experimental ground reaction forces and kinematics during gymnastics landings, to calculate their respective simulation run times and to determine what level of model complexity is required to assess injury risk. A subject-specific planar seven link wobbling mass model of a gymnast and a multi-layer model of a landing mat were developed for this study. Subject-specific strength parameters were determined that defined the maximum voluntary torque / angle / angular velocity relationship about each joint. This relationship was also used to produce subject-specific 'lumped' muscle models for each joint. Kinetic and kinematic data were obtained during landings from backward and forward rotating gymnastics vaults. Both torque-driven and muscle-driven models were capable of producing simulated landings that matched the actual performances (with overall percentage differences between 10.1% and 18.2%). The torque-driven model underestimated the internal loading on joints and bones, resulting in joint reaction forces that were less than 50% of those calculated using the muscle-driven model. Simulation time increased from approximately three minutes (torquedriven) to more than ten minutes (muscle-driven) as model complexity increased. The selection of a simulation model for assessing injury risk must consider the need for determining realistic internal forces as the priority despite increases in simulation run time. Introduction When landing from a dismount in Artistic Gymnastics the aim is to reduce the velocity of the mass centre to zero whilst over the base of support and within a single placement of the feet. Any steps or unsteadiness during landing can result in a score deduction between 0.1 and 0.3 (F.I.G., 2001). The successful landing from a vault (or other apparatus) poses a problem for a gymnast who must trade off technical difficulty with the probability of a successful landing and with the risk of injury. While minimising injury is a concern it is not always of paramount importance in competitive environments, such as at the Atlanta 1996 Olympics Games where an already injured gymnast completed a vault, further exacerbating her injury. The gymnast and coach aim to maximise performance and develop training regimes and technical strategies to achieve this. Similarly most of the computer simulation research in gymnastics, jumping and landing has been aimed at improving performance (Hiley and Yeadon, 2003; King and Yeadon, 2004) and has not considered the potential injury risks. Using a gymnast to investigate different landing techniques experimentally could lead to injury. On the other hand a forward dynamics computer simulation model of a gymnast and landing mat could be used to look at the performance enhancement of various landing techniques and gymnastic skills whilst safely assessing the associated injury risk. It has been reported that between 57% and 82% of injuries in gymnastics are acute, ranging from strains and sprains to fractures and dislocations, and that the lower extremity was the most injured, comprising 54% to 70% of all injuries (Andrish, 1985; Harringe et al., 2006; Jensen, 1998; McAuley et al., 1987; Meeusen and Borms, 1992; Snook, 1979). 31% of acute injuries were fractures to the lower extremity (Pettrone & Ricciardelli, 1987); the foot was mentioned separately, suggesting that the fractures were to the femur and tibia/fibula.


Background: A 61-year-old woman, known to have multiple sclerosis for many years, presented with a markedly distended abdomen, nausea, vomiting and mild fever of a few days duration. On physical examination the patient appeared ill and dehydrated. She indicated no pain. There was a severe distension of the entire abdomen, tachycardia, but no fever. Blood analysis revealed a marked elevation of inflammatory parameters.


Through the analyess on the process of mechanical vibration, the opposite and transform between the Kinetic and potential has been discussed. The disturb of the order and disorder for the Vibrated process has been forther analysed. The opposited factors of the vibrated process in external disturbs and from the transform of oppsited factors leads to the tronsform of contradiction has been ascertained.


Identifying protein interface is crucial for the prediction of protein-protein interactions and for protein functional classification. In this work, the protein structure is modeled as an undirected graph with the conservation amino- acid residues the vertices and all atom contacts between them the edges. We find that the conservation residue networks are characterized by intermediate values of clustering coefficient and characteristic path length, which are the typical property of small-world networks. The residues on the protein interfaces typically have higher degree and lower clustering coefficient values than that of the surface residues. Additionally, it is detected that the spatial clustering of the conservation residues is a general phenomenon, consistent with the cooperative nature of residues in determining the structure and function. These results indicate that the conservation residue network propensities can give us some new parameters in protein-protein interface prediction.


Minimize your time spent on common biostatistical analyses by maximizing your use of these macros. Put them to work calculating statistics and producing high quality report tables summarizing your results in Word documents. These macros are useful for conducting a complete analysis, from start to finish. Use them to 1) produce descriptive statistics, including frequencies and percentages for categorical variables; and n, mean, median, standard deviation, min, and max for quantitative variables; 2) produce parametric and non-parametric bivariate statistics with either quantitative or categorical variables, including Chi-Square test, Fisher's exact test, ANOVA, Kruskal-Wallis test, Pearson correlation coefficient, and Spearman rank correlation coefficient dependent on variable types; 3) look at the unadjusted associations of each variable with a binary or survival outcome, reporting odds ratios or hazard ratios, respectively; 4) conduct multiple regression using logistic regression or Cox proportional hazards models incorporating all variables or using a backward variable selection method. The capabilities of these macros and how to use them will be illustrated using data from a kidney stone questionnaire designed to examine the factors that influence patient preference for ureteroscopy vs. shock wave lithotripsy. The macros used for this study enabled production of comprehensive, professional looking reports, efficient communication and collaboration with investigators, and ensured that timely and high-quality service was delivered.


This paper examines the factors that influence scientists in their choice and persistence in an area of research, and compares the experience of scientists who enter a field early with those scientists who follow in their footsteps once the field becomes widely accepted. Evidence is presented from an international survey of more than seven-hundred scientists working in the field of neural networks. After controlling for cohort and experience effects, the results suggest that early entrants as a group are indeed different in both their motivations to enter and their persistence to remain in the field. In general, compared with scientists who enter late, early entrants are significantly less influenced by the social dynamics of the research community.


Using continuous controlled liftings of vector fields, we first prove for Bekka's (c)-and hence Whitney (b)-regular stratifications S that near every point of a stratum X with depth Σ (X) = 1 there exists a local C 0,1 foliation. Then we construct a local open book structure near each point of X and use this result to prove the general smooth version of the Whitney fibering conjecture near every point of an arbitrary stratum X of S. As a consequence we improve the Thom-Mather regularity of the local trivialization maps of a proper stratified submersion f : S → M into a manifold. In a famous paper of 1965 H. Whitney proposed a local fibering property around points of a complex analytic variety. More precisely he conjectured that every complex analytic variety V admits a stratification such that a neighbourhood U of each point is fibered by copies of the intersection of U with the stratum M containing the point. He asked also that the fibers be holomorphic manifolds and that their tangent spaces vary continuously as nearby points approach M. Note that if one does not require the continuity of tangent spaces to the fibers then the Thom-Mather isotopy theorem suffices to prove a smooth version of Whitney's conjecture. In 1989 R. Hardt and D. Sullivan gave a proof of a similar conclusion for holomorphic varieties but again without the essential continuity of the tangent spaces to the fibers. From 1993 the first author studied the possibility of obtaining the analogous property in the case of smooth real stratified spaces in his thesis under the direction of the third author who conjectured this property be true for Whitney (b)-regular stratifications.


BackgroundUnderlying mechanisms behind opioid-induced respiratory depression are not fully understood. The authors investigated changes in burst rate, intraburst firing frequency, membrane properties, as well as presynaptic and postsynaptic events of respiratory neurons in the isolated brainstem after administration of opioid receptor agonists. MethodsNewborn rat brainstem–spinal cord preparations were used and superfused with &mgr;-, &kgr;-, and &dgr;-opioid receptor agonists. Whole cell recordings were performed from three major classes of respiratory neurons (inspiratory, preinspiratory, and expiratory). ResultsMu- and &kgr;-opioid receptor agonists reduced the spontaneous burst activity of inspiratory neurons and the C4 nerve activity. Forty-two percent of the inspiratory neurons were hyperpolarized and decreased in membrane resistance during opioid-induced respiratory depression. Furthermore, under synaptic block by tetrodotoxin perfusion, similar changes of inspiratory neuronal membrane properties occurred after application of &mgr;- and &kgr;-opioid receptor agonists. In contrast, resting membrane potential and membrane resistance of preinspiratory and majority of expiratory neurons were unchanged by opioid receptor agonists, even during tetrodotoxin perfusion. Simultaneous recordings of inspiratory and preinspiratory neuronal activities confirmed the selective inhibition of inspiratory neurons caused by &mgr;- and &kgr;-opioid receptor agonists. Application of opioids reduced the slope of rising of excitatory postsynaptic potentials evoked by contralateral medulla stimulation, resulting in a prolongation of the latency of successive first action potential responses. ConclusionsMu- and &kgr;-opioid receptor agonists caused reduction of final motor outputs by mainly inhibiting medullary inspiratory neuron network. This inhibition of inspiratory neurons seems to be a result of both a presynaptic and postsynaptic inhibition. The central respiratory rhythm as reflected by the preinspiratory neuron burst rate was essentially unaltered by the agonists.


This study aims to apprehend resources that affect level of happiness according to the types of work and leisure in single-person households, and suggests measures to effectively manage. Single-person households not only have different demographic characteristics such as gender and age, but also they have different resources, so there is a need to look at them simple as an individual subject, but as a complicated system from more integrated view. Thus, this study saw the single-person household as an organism existing in a complicated environment based on examining the previous researches. This work deigned the research model by applying the human ecological point of view consistently interacting with the environment. This study suggested an hypothesis under the assumption that the resources such as leisure, infrastructure, social activity and work-life balance support system will influence the level of happiness of single-person household.


Urban regeneration and rural revitalization are becoming major policy initiatives in China, which requires new approaches for sustainability transitions. This paper reviewed the history of policy reforms and institutional changes and analysed the main challenges to sustainability transitions in China. The urban-rural systems were defined as a complex dynamic social-ecological system based on resilience thinking and transition theory. The notions of adaptation and transformation were applied to compose a framework to coordinate "resilience" with "sustainability". The findings indicate that China's urbanization has experienced the conservative development of restructuring socio-economic and political systems (before 1984), the fast industrialization and economic development leaned to cities (1984 to 2002), the rapid urbanization led by land expropriation and investment expansion (2002 to 2012), and the quality development transformation equally in urban and rural areas (since 2012). The sustainability transitions have been challenged by controversial institutional arrangements, concerning population mobility control, unequal social welfare, and incomplete property rights. A series of policy interventions should be designed and implemented accordingly with joint efforts of multiple stakeholders and based on the combined technocratic and bottom-up knowledge derived from proactive and conscious individuals and collectives through context-dependent social networks.


Purpose – The purpose of this article is to review the use of competence frameworks in the UK healthcare sector and to explore characteristics of the sector that may influence the success of projects to develop new frameworks.Design/methodology/approach – The paper draws on project reports and evaluations of practice in a range of recent projects to develop new competence frameworks.Findings – There are a number of competence frameworks in use in the UK healthcare sector, principally the NHS, designed for a range of purposes. There are many potential benefits of such frameworks. The main characteristics of the UK healthcare sector that can present difficulties to the development, and ultimate use, of such competence frameworks are the size, complexity, professionalisation and extent of other simultaneous change in the sector. Potential difficulties caused by these characteristics can be ameliorated by measures to align the development of the framework with priorities, interests and concerns of practitione...


InGaAs-OI and GeOI SRAM cells using optimized threshold voltage (Vt) design to enhance the intrinsic variation immunity of high-performance (super-threshold) and low-voltage (near-/sub-threshold) 6T SRAM cells are presented. For low-voltage SRAMs operating at low Vdd, low-Vt design shows smaller variability while the design trade-off between performance and leakage should be considered. For high-performance SRAMs operating at high Vdd, high-Vt design shows smaller variability. Moreover, compared with the SOI SRAMs with high-Vt design, InGaAs-OI/GeOI hetero-channel SRAM cells with high-Vt design exhibit improved Read/Write stability and performance, and maintain comparable RSNM variations for the high-performance SRAM applications.


Conflicting statements are to be found in the literature concerning the nature of the nuclear divisions in the tapetal cells of angiosperm pollen sacs. A number of investigators have m-iade casual observations concerning these divisions in the plant witlh whiclh they were working; and in a few instances, notably by Tischler (I905), Bonnet (I9I2), and Mascre and Thomas (I930), detailed studies of the divisions of the tapetal nuclei have been made. The earlier workers reported fragmentation, or amitosis, as the typical method of nuclear division in the cells of the tapetum. Strasburger (I882), reexamining his preparations, found mitotic figures in the tapetal cells and concluded that the appearances formerly described by him as amitosis result from the fact that two daughter nuclei remain attached and finally come to lie in close contact. Tischler (1905) in a study of three species of Ribes reported that the first division of the tapetal nucleus is by mitosis and that any further division is by constriction or fragmentation. Bonnet (I9I2), after critically examining the tapetal cells of ten species of angiosperms, concluded that amitosis does not occur in the nuclei of the tapetal cells and that figures suggesting amitosis are due to mitotic irregularities and nuclear fusions. In one of the plants studied by Bonnet, Datura Stramnonium, O'Neal (I920) reported that the nuclei of the tapetum divide by fragmentation. Mascre and Thomas (I930) agree with Bonnet concerning the absence of amitosis, but find that the tapetal cells may again become uninucleate through nuclear fusions. The presence of typical mitoses in the tapetal cells of Buginivillaea glabra (Cooper, 1931) suggested an examination of other angiosperms with the idea of determining, if possible, the exact nature of these nuclear divisions. Material of 7 mnonocotyledons and 36 dicotyledons, representing in all 24 families, was collected and examined. With the exceptions of the preparations of Pereskia acutleata, which were furnished by Dr. R. I. Evans, and those of Liliunm canadense, Ranunculus fascicularis, Meniispermnum canadense, and Gossypiuns barbadense, which were loaned by Dr. E. L. Fisk, the material for this study was collected in the botanical greenhouses or about the campus of the University of Wisconsin. Flemming's medium solution was used as a


Vedolizumab is a monoclonal antibody which blocks integrin α4β7 inhibiting trafficking of T-lymphocytes into the gut. Unfortunately, up to 60% of vedolizumab patients experience non-response. The mechanism of action of vedolizumab is not elucidated, predictors of response are unknown and data for local drug distribution in the gut are lacking. In this clinical trial, we investigated the feasibility of assessing local distribution of fluorescently labelled vedolizumab in the gut mucosa of inflammatory bowel diseases (IBD) patients to finally enable prediction of therapy response in individual patients.

 Vedolizumab (Entyvio, Takeda Pharma) was labelled to IRDye 800CW under cGMP conditions to yield clinical grade vedolizumab-800CW. In this dose-escalation trial, vedolizumab naïve IBD patients and IBD patients treated with vedolizumab for at least 14 weeks were included. Patients received an intravenous dose of fluorescently labelled vedolizumab of either 0 mg, 4.5 mg, 15 mg or 15 mg + 75 mg unlabelled vedolizumab 3 days prior colonoscopy. In vivo fluorescence imaging was assessed by fibre-based wide-field fluorescence molecular endoscopy (FME) and quantified by spectroscopy in healthy, mildly inflamed and severely inflamed tissue. All assessed tissue was biopsied for ex vivo examination of the fluorescent signal, fluorescence microscopy and spectroscopy.

 Up to submission 34 patients completed tracer injection and FME. An interim analysis was performed after 20 patients (5 in each dose group), which showed in severely inflamed tissue an 8 fold higher fluorescent signal in the 15 mg dose group (0.049 Q*μfa,x [mm-1]) compared to the control group (0.006 μfa,x [mm-1]) (p<0.05). Furthermore, the fluorescent signal within the 15 mg dose group was also 2.5 fold higher compared to healthy tissue (0.019 Q*μfa,x [mm-1]) (p<0.05).The addition of unlabelled vedolizumab gave similar results to the 15 mg group (p>0.99), suggesting that the drug target was still not saturated. The optimal dosage group of 15 mg was expanded up to 18 IBD patients, amongst them 6 IBD patients after 14 weeks of treatment regimen. Fluorescence microscopy showed clustering of fluorescent signals especially in inflamed mucosa. Additional experiments to detect vedolizumab target cells are ongoing.

 In vivo visualization of fluorescent vedolizumab revealed a clear dose-dependent correlation between mucosal drug concentrations and the severity of mucosal inflammation. Fluorescence molecular endoscopy is a promising novel tool to get insight in drug distribution in IBD, detect target cells, assess target engagement and possibly predict therapy response in individual patients.


Is feeling pain in a bodily location, say, in one's elbow, a form of perception or something that essentially involves introspection? Am I perceiving something in my elbow when I feel pain there? Or am I engaged in some form of introspection about my awareness of something there? In popular culture or even among scientists, the term 'perception' is often used in a very broad sense to designate any kind of ongoing epistemic access to (or, some form of awareness of) something (anything) in real time. Used in this sense, the common practice of using expressions like 'pain perception' or 'perception of pain' (popular among pain scientists) 1 may be unobjectionable. Indeed, the term 'perception' in this broad sense may also be used to characterize introspection itself. Whatever ultimately the nature of introspection turns out to be, it is by definition a form of direct first-person access (subjective, from inside) to one's own mental states, processes, events, or to their mental features. In this minimal sense, it is something that may already be covered by the broad sense of 'perception' just mentioned. But there is a narrower sense of 'perception' with which 'introspection' is to be contrasted. In the narrower sense, perception is ongoing epistemic access to something that is other than one's own mental states or features. This is the familiar epistemic activity that occupies most of our ordinary waking lives when we see, hear, smell, taste, or touch something in or outside of our bodies. In this sense, perception is access to something extra-mental in the sense of being beyond our own mental states. This is typically access to worldly objects (including our own bodies), their physical properties, states or conditions. When I see a lemon in front of me, touch it, smell it, taste it, I am perceiving the lemon and its physical features, its color, shape, sounds it makes when I take a bite or tap on it, its texture, odor, taste, etc. In other words, in perception I am getting information about the physical objects in the environment surrounding me and my body, and this information is typically made available to me for recognition, identification, categorization, etc. — or more generally, for cognizing and further mental processing or motor action. In all this, and what is essential for the narrow sense of 'perception,' the mental activity is world-directed. In introspection, it is internally (mind) directed. This is not to deny that perception in the narrow sense and introspection can co-occur — or perhaps even always cooccur. Indeed, when I perceive the lemon in front of me, I may also be simultaneously attending to the way I sense or experience it. This is epistemic access to the peculiar way in which the


: Twenty pairs of 5 th grade children used a tangible tabletop sustainability game to create a world they would want to live in to share with the rest of the class. Half of the pairs were assigned particular roles with associated game controls (positive interdependence condition) while the other half were not (control condition). Results showed that pairs in the assigned roles/controls condition gave more in-depth explanations to their partners about what they wanted to do in the game, but did not negotiate with each other more frequently than control pairs. They also had fewer but longer instances of jointly resolved conflict. Contrary to some previous findings, all pairs in both conditions were found to work together (rather than in parallel / competitively) the entire time. The general finding is a somewhat limited, but consistent, positive effect of the assigned roles/tools manipulation on collaborative processes.


Abstract The frictional and thermal contributions to S22,2 (p), the dominant wave type in the progressive solar semidiurnal pressure wave, are evaluated from upper air observations at nine rawinsonde stations. The theoretical basis for the investigation follows from the approximation of friction as a potential force in the tidal equations. The model parameters and boundary conditions are those adopted by Siebert. Surface friction is evaluated semi-empirically, by the use of a friction model which is essentially an adaptation, to the semidiurnal motions, of the Ekman theory of the boundary layer. The assumption of a constant coefficient of the vertical transfer of momentum leads to uncertainties in the magnitude of the frictional contribution to the wave. Further uncertainties arise from a systematic error in the observed temperatures, caused by radiation effects on the radiosonde instrument. The latter error, however, is believed to be negligible in the lower troposphere, where an unexpectedly large tempe...


In the Han Dynasty,th "eDefense Unit" is a kind of military settlement and action district for"the Barbarians Guarders",it is just like a sort of nationality autonomous district.Because of lying in the frontiers,the "Defense Unit" became a fraction in the frontier military and political management system in the Han Dynasty.However,the "Defense Unit" was NOT found in the historical masterpieces,but was mentioned by the Han Dynasty Bamboo Books which were found by the archaeologists.Nobody have investigated the problem about the"Defense Unit",especially about its social safety functions.The article intends to smooth away to improve the research of the "Defense Unit" as the complementary opinions.


Abstract: In March 2016, a group of artists and scholars met at York University in Toronto to consider visual arts produced by indenture-descendant creators. Among them were filmmakers Richard Fung and Ian Harnarine, who engaged in a dialogue about their work and responded to inquiries posed by moderator Andil Gosine and others present at the workshop, including Ramabai Espinet and Patricia Mohammed. The conversation focused in particular on Fung's and Harnarine's films centering Indo-Caribbean cultural representation: Fung's 2012 feature-length documentary Dal Puri Diaspora, that traces the origins of the roti, and Harnarine's 2011 Doubles with Slight Pepper, in which Trinidadian street food features in a story about migration and a father-son relationship.


This is the second paper on Concept Calculus, following the first paper that treats Better Than and Much Better Than. Concept Calculus investigates basic formal systems arising from informal commonsense thinking, establishing interpretability


AbstractA survey is presented of the various processes measurable at HERA in whichtwo photons are involved. Their current experimental status and futureprospects are discussed. Introduction The majority of physics processes studied at HERA involve just one photon at the basiclevel, namely the virtual photon emitted by the incoming electron or positron. At veryhigh virtualities, this becomes an electroweak object. Here I present a survey of thevarious types of HERA process in which two photons play a central role. They may beconsidered in the following categories:(a) Prompt photon production(b) Bethe-Heitler processes(c) Radiative processesWe shall consider the experimental progress so far in studying the above processes, andtheir place in the larger arena of HERA physics. 1. Prompt photon production A so-called "prompt" photon is one that emerges directly from a hard QCD subprocess,rather than as the product of a decay. So far, measurements at HERA have been confinedto prompt photons produced in photoproduction reactions. Typical examples of lowest-order diagrams for these processes are shown in fig. 1. As usual, these LO diagrams maybe classed as direct or resolved photoproduction processes according to whether the entireincoming photon takes part in the hard QCD scatter, coupling in a point-like manner, orwhether it couples hadronically as a source of quarks and gluons and these take part in thehard QCD scatter. In the processes under consideration here, one of the hard outgoingpartons is a second photon.There is in fact only one LO direct diagram of this kind; in it the incoming photonmay be viewed as scattering elastically off a quark in the target proton. This is known


In this paper, we attempt to give spatial semantics to Web pages by assigning them place names. The entire assignment task is divided into three sub-problems, namely place name extraction, place name disambiguation and place name assignment. We propose our approaches to address these subproblems. In particular, we have modified GATE, a well known named entity extraction software, to perform place name extraction using a US Census gazetteer. A rule-based place name disambiguation method and a place name assignment method capable of assigning place names to Web page segments have also been proposed. We have evaluated our proposed disambiguation and assignment methods on a Web page collection referenced by the DLESE metadata collection. The results returned by our methods are compared with manually disambiguated place names and place name assignment. It is shown that our proposed place name disambiguation method works well for geo/geo ambiguities. The preliminary results of our place name assignment method indicate promising results given the existence of geo/non-geo ambiguities among place names


Recent advances in technology have radically changed the view of education. Today, there are millions of distance learners in the world. For example, United States (US) has had rapid growth in the use of technology for distance education. Like US, Turkey as a developing country and tries to develop its educational system. As there is no significant difference found between distance education and traditional way of education (Lockee, Burton & Cross, 1999), it provides learners a new avenue to develop their knowledge, get certificates, and take courses online. Therefore, there have been many studies carried out in distance education in the world and in Turkey. Especially on design and development of courses and programs via web-based education have started in the governmental universities as well. Some of the private universities are also seriously conducting their studies on distance education. For all of these studies, many articles have been published and many theses have been written. Based on these researches, this paper examines distance education in Turkey, its past, its current situation, and especially its future. How distance education has grown up, how it is growing, and what things are going to happen will be discussed and some suggestions for future reference will be given in this paper; therefore, some of our advantages and disadvantages in terms of distance education will also be examined.


2011 Great Eastern Japan Earthquake had a negative influence on the lifestyle of the Japanese population. The purpose of the present study is a comparison of the physical activity among adolescents belonging to a middle school in the tsunami stricken coastal area of Higashi-matsushima city with less seriously damaged areas in Aomori city. Three hundred seventy four students in Higashi- matsushima and 399 students of Aomori were assessed by a self-administered questionnaire at the end of July 2011. Time spent in a sedentary state during weekdays as measured in the questionnaire was significantly higher for the students in Higashi-matsushima (553 ± 249 min/day) than the students in Aomori (459±304 min/day). Physical activity among middle school students in the tsunami stricken coastal area, which was conducted five months after the earthquake, may be lower than that among students in the less seriously damaged area.


This paper outlines two variations of Decision Digrams, the 2VBDD and 2VRMBDD. It outlines the background for BDD and RMBDD expanded with respect to one variable and the new 2V(RM)BDD when the expansion is with respect to two variables. Examples are realised using 2 variable nodes and implemented using Universal Logic Modules (ULM) and RM-ULMs. The resulting solutions are variable oder dependent. Lastly the total number of possible solutions is also outlined in this paper.


The
study of the water
status and activity of catalase in Chinese tea plants (Camellia sinensis (L.)
O. Kuntze) and hazelnut (Corylus pontica C. Koch.). The indicators,
which not only describe the physiological state of plants in the stressful
period, but also allow it to
identify more adaptive varieties within a given area was determined. Analysis
of catalase activity data in Chinese tea and hazelnut revealed the presence of
similar patterns: there is a change in enzymatic activity in response to
hydrothermal factors. It is established that the stable varieties Camellia sinensis (L.)
O. Kuntze and Corylus pontica C. Koch. characterized by
a more active catalase, which is of particular importance during droughts. The
water regime parameters variance scale for Camellia sinensis was
developed, which allows differentiating varieties into groups of varying
degrees of stability. It is shown that all
methods that are used to estimate stability of plant species to extreme
environmental conditions are based on several basic principles connected with
peculiarities of adaptation mechanisms. The result was a selection of
diagnostic indicators proposed for assessing adaptability: the water content of
the leaf tissue, water-holding capacity of leaves, and concentration of
cellular juice sprouts and activity of catalase.


In this paper, we first introduce a general architecture of an energy management system in a home area network based on a smart grid. Then, we propose an efficient scheduling method for home power usage. The home gateway (HG) receives the demand response (DR) information indicating the real‐time electricity price, which is transferred to an energy management controller (EMC). Referring to the DR, the EMC achieves an optimal power scheduling scheme, which is delivered to each electric appliance by the HG. Accordingly, all appliances in the home operate automatically in the most cost‐effective way possible. In our research, to avoid the high peak‐to‐average ratio (PAR) of power, we combine the real‐time pricing model with the inclining block rate model. By adopting this combined pricing model, our proposed power scheduling method effectively reduces both the electricity cost and the PAR, ultimately strengthening the stability of the entire electricity system.


Augmentative and Alternative Communication Systems (AAC) improve the communication of people with physical, psychological and cognitive difficulties. As the community needing such systems is large, and personal needs vary, the AAC must be adapted to each individual. In the majority of cases, adaptation implies an evolution of the system in real time. This paper proposes the architecture for an adaptable and unanticipated AAC system used for autistic children. It is based on a two-tier architecture: the first is a communicator based on an adaptive hypermedia, and the second is a meta-communicator which enables the first to evolve during its execution. Implementation consists of the connection of a PDA device (for the communicator) to a computer (for the meta-communicator) by means of a wireless network.


Nowadays, a huge number of papers have documented the ability of diffusion magnetic resonance imaging (D-MRI) to highlight normal and pathological conditions in a variety of cerebral, abdominal, and cardiovascular applications. To date, however, the role of D-MRI to investigate musculoskeletal tissue, specifically the cancellous bone, has not been extensively explored. In order to determine potentially useful applications of diffusion techniques in musculoskeletal investigation, D-MRI applications to detect osteoporosis disease were reviewed and further explained.


For the integration of higher shares of volatile renewables, it is important to analyse long- and short-term variations. We propose and evaluate different methods for wind power simulation on four spatial resolution levels in Brazil using NASA's MERRA-2 reanalysis data set. In particular we assess spatial interpolation methods and spatial as well as spatiotemporal wind speed bias correction using wind speed measurement data and mean wind speeds. The resulting time series are validated with daily wind power generation. The main purpose of our analysis is to understand whether global information on wind speeds can compete with locally measured wind speed data as a source of bias correction, and which combinations of methods work best. Results show that more sophisticated methods, for both spatial interpolation and wind speed correction, are not always necessary to obtain good simulation results. Global Wind Atlas data can compete with measured wind speeds as a source for bias correction, a result which, due to the global availability and high spatial resolution, paves the way for bias-corrected global wind power simulation. Only on the level of wind parks, bias correction did not improve results. To achieve better results here, higher spatial resolution reanalysis data would be needed.


Furniture industry is the industry that processes raw or semifinished material from wood, rattan, or other natural material, into products with higher value added and benefit. Because of a rise in consumer demand each year, the furniture industries should have much attention. High consumer demand may cause production process-related problems that damage the environment. Such environmental damage may be caused by waste, raw materials, or production process. High consumer demand in furniture industry brings negative impacts not only to the environment but also to the society. Social impact assessment is needed to evaluate how a product or a process influences workers, consumers, citizen, and value chain. This study uses life cycle assessment method with the help of SimaPro software to determine the environmental impact, and social-life cycle assessment to determine the social impact. The largest contributor to environmental impact is the use of acrylic varnish. Substitution acrylic varnish with woodstain-water based aims to lead to a circular economy by reducing adverse impacts on the environment. The replacement of acrylic varnish with woodstain water based reduces the environmental impact score by 24.8%. Social impacts score on the workers and local community stakeholder are categorized as poor.


BACKGROUND
HIV-1 infected and immune-activated macrophages and microglia secrete neurotoxins, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), which play major role in the neuronal death. It has been shown that different HIV-1 variants have varying abilities to elicit secretion of TNF-α by peripheral blood mononuclear cell (PBMC); however, whether the difference of gp120 gene could affect the secretion of TNF-α and IL-1β by glial cells is unknown. The aim of this study was to explore the association between gene diversity and induction of neurotoxic cytokines.

METHODS
In this study, we constructed retroviral vectors MSCV-IRES-GFP/gp120 using HIV-1 gp120 genes isolated from four different tissues of one patient who died of AIDS dementia complex (ADC). Recombinant retroviruses produced by cotransfection of MSCV-IRES-GFP/gp120, pCMV-VSV-G and pUMVC into 293T cells were collected and added into U87 glial cells. Concentrations of TNF-α and IL-1β secreted by transduced U87 cells were assayed with ELISA separately.

RESULTS
The four HIV-1 gp120 were in the different branch of the neighbor-joining tree. Compared to the pMIG retrovirus (gp120-negative) or U87 cells, all the gp120-positive recombinant retroviruses induced more TNF-α (P < 0.01) and IL-1β (P < 0.01). In addition, compared with the L/MIG retrovirus, all the three brain gp120-positive recombinant retroviruses induced less TNF-α (P < 0.01) and IL-1β (P < 0.01).

CONCLUSIONS
HIV-1 gp120 could induce U87 cells secret more TNF-α and IL-1β again. The more important is that difference of HIV-1 gp120, especially cell-tropism may account for the different ability in eliciting secretion of TNF-α and IL-1β, which might supply a novel idea helping understand the pathogenesis of ADC.


Stem cuttings from mature trees and coppice regrowth of three red ironbark eucalyptus (Eucalyptus sideroxylon A. Cunn. ex Woolls) genotypes were used to study the rooting response over time. Mature...


Aim. This work, implementative (applicative) in nature, raises issues related to the modeling of individual performance in high-risk situations. Assuming that individual actions are the basis for a team's game, praxeological assessment was conducted regarding the game of individuals in high-risk situations. These activities, due to the specificity of sports games (group pressing) and major difficulty of execution (action in discomfort), constitute a significant element, which in the modern game becomes the necessity for organized training. Basic procedures. Evaluation of actions in difficult situations was conducted on the example of the performance of the Polish football national team and their rivals during the EURO 2012 tournament (observation of 152 players). The study used the method of noted observation, which was based on direct secondary observation (DVD material), with the possibility to repeatedly replay the events that were the subject of research. The resulting data were recorded on a praxeological observation sheet. Results and conclusions. Data analysis allowed to determine the level of individual actions in situations of risk, which for the purposes of application determines not only the evaluation of these actions against the dominant football teams in Europe, but above all sets the direction of modeling games in the organized training of football players in Poland.


The idea of hybrid energy grids is to coordinate the operation of multiple grids and interconnect them via coupling points that enable mutual transfer of energy. Hybridization has the potential to generate synergy effects in terms of improved energy efficiency, supply safety, reliability, and cost-effectiveness. We present the results of a case study conducted as part of the project OrPHEuS. In this study the hybridization potential of the electricity and heating grid of a northern European city is investigated, where the coupling points under consideration are a CHP plant and a large-scale electric boiler. Cooperative control strategies are applied to coordinate the energy exchange between the grids according to real-time supply and demand curves. Our study follows a holistic approach, conducting both fine-grained operational simulations and long-term economic studies that were developed in cooperation with a local energy provider and grid operator. The investigations include multiple experiments to cover a wide range of assumptions regarding future demand and price conditions and coupling point configurations. Our results demonstrate that the hybrid approach is an effective means to reduce the dependence on oil, saving up to 92% of CO2 emissions, whereas on the economic side the benefits are strongly depending on the future market development.


This correspondence presents a complete solution to the problem of constructing maximal q -nary codes, for any word length n and minimum distance d in the region qd \geq (q - 1)n . Several interesting results regarding the interdependence of these codes are developed, which reveal the unique structure of the code spaces of the region qd \geq (q - 1)n . Some new maximal codes are obtained for the region qd .


An experimental study of the interaction of a laser plasma with a flat screen, a wire, a concave cylindrical surface, and two flat plates held at an angle from each other, is carried out. By simultaneously observing the time-integrated spatial structure of the plasma emission in various spectral regions and the time evolution of the plasma emission intensity in various spectral lines, comprehensive information on the nature of the plasma-obstacle interaction is found. The study demonstrates that it is possible to control the properties of a recombining laser plasma by placing obstacles of various shapes in its path and that the luminous emittance of the plasma can be increased greatly by using cylindrical-tube and roof-shaped obstacles.


Aim: To determine the peculiarities of CT patterns in immunocompetent patients with pulmonary mycobacterioses caused by slowly growing nontuberculous mycobacteria (M. avium, M. kansasii). Materials and methods: We studied 65 patients with pulmonary mycobacterioses aged 54.3±0.2 years. The disease duration was 4.2±0.3 years. In all the patients the diagnoses were microbiologically verified. The patients were divided in two groups. Group 1 included 48 patients with pulmonary mycobacteriosis caused by M. avium. Group 2 included 17 patients with pulmonary mycobacteriosis caused by M. kansasii. Results: 1. Patients with pulmonary mycobacterioses caused by slowly growing nontuberculous mycobacteria had varied radiological signs, such as bronchiectasis, cavities, focal and infiltrative changes in the lung tissue. 2. Bronchiectasis accompanying pulmonary mycobacterioses caused by slowly growing was found in 66% of patients infected with M. avium. Bronchiectasis had unilateral localization, oftener in the middle lobe of the right lung or the left lung lingulas. 3. The predominant sign of pulmonary mycobacteriosis caused by M. avium was injury of the bronchi and the surrounding lung tissue in 85.4% of patients. 4. The "triad" of radiological signs was found in 35.4% of patients infected with M. avium: bronchiectasis, focal dissemination and fibroatelectasis of the lung tissue; all spread to different degrees. 5. Radiological patterns in patients infected with M. kansasii were similar to those in pulmonary cavitary TB in 41.1% of cases, infiltrative TB – in 17.6% of cases, tuberculomas – in 17.6% of cases.


Using a two-channel model, we investigate theoretically the binding energy of confinement-induced Feshbach molecules in two-and one-dimensional ultracold atomic systems near a Feshbach resonance. We show that the two-channel prediction will evidently deviate from the simple single-channel theory as the width of Feshbach resonances decreases. For the one-dimensional system, we perform a full two-channel calculation, with the inclusion of bare interatomic interactions in the open channel. Away from the resonance, we find a sizable correction to the binding energy, if we neglect the bare interatomic interactions as in the previous work [D. B. M. Dickerscheid and H. T. C. Stoof, Phys. Rev. A 72, 053625 (2005)]. We compare our theoretical results with the existing experimental data and present predictions for narrow Feshbach resonances that could be tested in future experiments.


Results are presented of an experimental investigation on the effects of modification to the leading edge geometry of two NACA airfoils with different aerodynamic characteristics. The modification was inspired by the humpback whale flipper, which has rounded tubercles on its leading edge resembling the shape of a sine curve. Force measurements on both modified and unmodified 2-D airfoils show that tubercles are more beneficial for the NACA 65-021 airfoil than the NACA 0021 airfoil. Also, for smaller amplitude tubercles, the modified NACA 65-021 airfoil outperforms its unmodified equivalent for most angles of attack. Hydrogen-bubble visualisation was used to identify characteristic features of the flow for airfoils with tubercles. It appears that the velocity behind the troughs is greater than behind the tubercles themselves at the leading edge. Downstream from the leading edge, the flow from behind the peaks seems to be entrained into this region, giving rise to the formation of stream-wise vortices.


Multilayer ceramics was prepared by stacking Al2O3 slices on which using screen-printing method to brush Al slurry and heat treated at 750 ℃. The composition of the Al swrry were observed through visible heart treatment process from 25 ℃ to 800℃ of Al slurry using self-made equipment, and XRD analysis of Al slurry drying at 25 ℃ and heart treated at 650 ℃ and 750 ℃ was carried on. In addtion the bond strength of Al slurry was measured, and the result was contrasted with the AB glues and 502 glues. The SEM observation and analysis of the cross section and the crack propagation of the multilayer ceramics were done based on the mechanical properties of the multilayer ceramics researched in former work to explain mechanical behavior of the multilayer ceramics.


With the development and advancement of technology, remote sensing data of MODIS satellite become more precise, loved and applied by relevant researchers widely. This software enables remote sensing data of EOS/MODIS satellite's automated ordering and address of FTP resource's accessing, providing convenience for users. Currently, the software with stable and reliable performance, is robust, fully automated, and can provide services to all kinds of users of remote sensing data of MODIS satellite.


Background: It is still an open research area to theoretically understand why Deep Neural Networks (DNNs)---equipped with many more parameters than training data and trained by (stochastic) gradient-based methods---often achieve remarkably low generalization error. Contribution: We study DNN training by Fourier analysis. Our theoretical framework explains: i) DNN with (stochastic) gradient-based methods often endows low-frequency components of the target function with a higher priority during the training; ii) Small initialization leads to good generalization ability of DNN while preserving the DNN's ability to fit any function. These results are further confirmed by experiments of DNNs fitting the following datasets, that is, natural images, one-dimensional functions and MNIST dataset.


A series of new Schiff bases of 3-alkyl-4-amino-1,2,4-triazol-5-thione were prepared by condensation reaction in the presence of concentrated hydrochloric acid. The structures of obtained compounds were characterized by EA, IR, ~(1)H NMR and ~(13)C NMR. The X-ray crystallographic analysis of compound IIa indicated that the configuration of the CN double bond in compounds II and III was E and its structure was thione tautomer rather than thiol tautomer.


Tom LeClair's Passing Through completes the Michael Keever trilogy after Passing Off (1996) and Passing On (2004). The cover copy announces it as a "stand-alone novel," but a critic or reviewer who buys into that hype does a disservice both to the author and to his readers. It is as if a panel of a Hieronymus Bosch triptych were to be called a stand-alone painting or the freestyle laps of a Michael Phelps individual medley were to be timed without reference to the other strokes or Le Temps Retrouve (1927) were to neglect Le Cote de Chez Swann (1927) and Le Cote de Guermantes (1920) or the eight other volumes of "ways" that lead us there. From A to Z (John Updike's Angstrom, Philip Roth's Zuckerman), serial fictions have long been a staple of our literature. Setting aside the commercialized phenomena of sequels, prequels, and spin-offs, consider how James Lee Burke, Jerome Charyn, Michael Connelly, Robert Crais, James W. Hall, Donna Leon, William Murray, Ian Rankin, Peter Robinson, and John Sandford (to name a few in no special order) pursue the evolving and aging careers of, respectively, Dave Robicheaux, The Pink Commish, Harry Bosch, Elvis Cole, Thorn, Guido Brunetti, Shifty Lou Anderson, John Rebus, Alan Banks, and Lucas Davenport; the reader is engaged both by the familiarity of procedures, cross-references, and stylistic idiosyncrasies, and by the subtle departures from type. I would identify a half dozen exemplars of the multi-text form: Daniel Fuchs's underrated "Williamsburg Trilogy"; Henry Roth's obsessive Mercy of a Rude Stream (1994); Mark Harris's inimitable Henry Wiggen books; William Gibson's brilliantly inventive "Cyberspace trilogy"; William Kennedy's masterly Albany novels; and George Garrett's "Renaissance Trilogy"—Death of the Fox (1971), The Succession (1983), and Entered from the Sun (1990)—arguably the greatest unsung work of its time. Each of these presents a novel way of interrelating separate fictions in a whole that outdoes their individual excellence. Finally, at the risk of having this piece read like a peckish if not puckish parody of Roberto Bolaño; acknowledging that I slipped a Scot, a Brit, and an ex-pat in Venice into the list above; and resisting the lure of detours to Gormenghast, Middle-earth, and Narnia; I would mention three landmark works of twentieth-century English fiction: Ford Madox Ford's Parade's End, Anthony Powell's A Dance to the Music of Time, and Lawrence Durrell's Alexandria Quartet. The point is that each of these uses the serial format in a distinctive and highly original way, that although most of the individual volumes may stand alone each is diminished by being blinkered out from its siblings, and that the whole is always greater.... And that is precisely the measure of LeClair's accomplishment. Passing Off (along with Alan Lelchuk's Playing the Game [1995]) showed that basketball fiction could rise to the literary heights traditionally reserved for baseball novels like Jerome Charyn's Seventh Babe (1996), LaMar Herrin's Rio Loja Ringmaster (1977), Roth's Great American Novel (1973), and Robert Coover's Universal Baseball Association, J. Henry Waugh, Proprietor (1992). LeClair's name does not appear on the title page; with a Nabokovian device, he presents the book as an autobiographical account of the narrator's "Season in the Greek Basketball Association." Moreover, we soon learn, because of the rules governing team membership, he has had to fake his name as Kyvernos, claiming that his grandfather had changed it to Keever, when "actually" his grandfather had been a McKeever. Our player/ narrator is now three removes from the author, wearing a double mask, itself covered with an additional deception since he must conceal the name change from his wife, Ann. In his pressing need to play the game(s) and get paid what he'd been promised, Keever is trapped into an involvement with desperate eco-terrorists. Their conspiracy supersedes the focus on basketball, while reflecting the play of the games in a distorting mirror and extending the playful exploration of language itself. His final escape, both from Greece and the bizarre caper, involves buzzer-beating heroics and the skills of a deceptive point guard. And along the way, the author, the narrator, and several other characters are shown to be passing themselves off with false identities.


The authors demonstrate a new technique for high sensitivity gas permeation measurements by integrating mass spectrometry with programed accumulation, detection, and evacuation of permeant. After passing through the film of interest, the gas permeant is captured and accumulated in an isolated ultrahigh vacuum (UHV) volume. The permeant is then allowed to enter an adjacent residual gas analyzer (RGA) and the resulting partial pressure increase is correlated with the steady state permeation rate. Calibrated results are given for helium and argon permeation through polymer films. The measured detection limits of the system are 1.8×10−4cm3∕m2day for helium and 2.5×10−4cm3∕m2day for argon. Both values are several orders of magnitude lower than what is available from commercial instruments or similar RGA-based instruments. Potential applications of this technique include measurement of oxygen and water vapor permeation with sensitivities required for assessment of ultrabarrier coatings.


Organizing unstructured information from books into a well-defined structure is a significant challenge in digital libraries. Most digital libraries can provide only search services at the granularity of books and few libraries allow books to be accessed at the granularity of chapters, as manually constructing directory information for books is time-consuming. Extracting structured data from scanned books thus remains an urgent and important work. In this paper, we propose a novel structured data organization framework called CMSOF to organize scanned data automatically, and apply it to a Chinese medicine digital library. In the framework, image blocks and text blocks on the scanned page of books are separated based on the gray histogram projection method or a hybrid method of region growth and the Ada-Boosting classifier at first, and then the text structure is obtained from text blocks by text size and font type recognition. Finally, image blocks and structured OCRed text are correlated at the semantic level. By integrating the structured data into a Chinese medicine information system (CMIS), we can organize the Chinese medicine books well and users can access the books with flexibility, which indicates that CMSOF is an efficient framework to organize books mixed with images and text.


This study examined if modified Wingate Anaerobic Test (Wingate method) and EvansQuinney Anaerobic Test (Evan-Quinney method) procedures could be applied to the measurement of maximal anaerobic power output (POmax) which is usually determined during 8-s maximal cycling depending predominantly on alactacid energy sources. The criterion measure of POmax was either the highest power output among 5 to 7 power outputs measured at different workloads (Selection method) or the peak power output estimated from quadratic regression (Peak method). POmax and anaerobic power outputs with these four methods were measured during 8-s maximal cycling on Monark bicycle ergometer with toe-stirrups. Forty-four young athletes (25 males and 19 females) served as subjects. Analysis of the data indicated that: 1) There was a very high correlation (r=0.995, P<0.001) between POmax determined by Selection and Peak methods, with no statistical difference in their absolute means. 2) POmax determined by Wingate method correlated (r=0.937, P<0.001) significantly with POmax determined by Peak method, while mean values differed significantly. 3) POmax determined by Evans-Quinney method also correlated (r=0.890, P<0001) significantly with that determined by Peak method; however, mean values differed significantly and degree of the difference in POmax was particularly greater in females. It is concluded that both Wingate and Evans-Quinney methods with a cycling duration of 8 s might be applicable for the assessment of POmax by utilizing linear regression equations developed in this study. Further studies are needed as to the feasibility of using these methods, particularly on females. (J. Physical Fitness Japan 1986, 35: 161•`167) key words:最 大無酸 素 性 パ ワ ー,Wingate変 法,Evans-Quinney変 法,最 大 自転 車 作 業


In order to obtain a higher radiation efficiency and thereby enhance the sound of bass bells, the Malmark company makes a bass handbell of aluminum. [Rossing, et al., MRS Bull. 20, 40 (1995)]. These aluminum bells are larger in diameter than the corresponding bronze bells, and they have lower coincidence frequencies, both of which lead to more efficient radiation of bass notes. In addition they are considerably lighter in weight, and thus they are more easily handled by bell ringers.


Excerpt It has been a scant 7 years since homocystinuria was first described as an inborn error in the metabolic pathway from methionine to cystine. The genetic lesion has been established as an au...


Objective:To investigate the effects of isoprenaline on lipopolysaccharide(LPS)-induced secreting of TNF-αand IL-10 in BALB/c murine peritoneal macrophages and effects of the capability of phagocytizing.Methods:Isoprenaline with the concen- trations of 10 mol/L、100 mol/L、300 mol/L were added in BALB/c murine peritoneal macrophages cells culture fluid,and then 10 g/mL of LPS was added after 2 hours,the supematants were collected for measuring the levels of TNF-αand IL-10 by ELISA kit after 6h and 24h respectively and was observed for the capability of peritoneal macrophages phagocytizing neutral red.cells.Results:10ug/mL of LPS induced the increase of TNF-αand IL-10 significantly,when isoprenaline plus LPS was added into the medium.The TNF-αproduction was suppressed and the IL-10 production was increased in a dose-dependent manner.Isoprenaline could increase the capability ofphago- cytizing neutral red.Conclusions:Isoprenaline down-regulates LPS-induced pro-inflammatory mediators production in macrophage,but upregulates LPS-induced anti-inflammatory mediators production.Isoprenaline increases the capability of phagocytizing neutral red.


The present invention relates to a cooling device and a manufacturing method thereof of the electrical component. A inventive apparatus comprises a metal radiator formed member 7 that is thermally coupled to the metal mass of the components forming the heat dissipating mass 5. According to the present invention, facing each other, and one surface of the dissipating mass 5 which is known as dissipating surface 5A, by at least one heat sink 10 formed by autogenous welding between the one face 7A of the radiator 7, radiator 7 is thermally coupled to the dissipating mass 5. The present invention, for example, can be used to cool the electronic components in the power electronic module.


ABSTRACT Alkaline phosphatase (ALP) is a hydrolase that releases phosphate, a crucial nutrient supporting formation of many macromolecules. The oligotrophic sediments of Central Indian Basin (CIB) were examined for the extent of ALP activity in 20 cores up to 20 cm depth along with other biogeochemical parameters. Northern and southern stations distinctly clustered based on pore water phosphorus (P) concentrations. ALP appeared more active in south due to more P and organic carbon (C) limitation. Central transition profiles revealed interesting mixed diagenetic and geothermal influence. Inter- and intrazonal differences suggest that broadly established paradigms applicable to water columns may deviate in space and time in sedimentary systems. Gross differences in redox status could govern differential response in ALP activity under similar hydrostatic pressure. Hydrothermal scavenging reactions striping soluble P from pore water might be widespread in CIB albeit at extreme low intensities. ALP might redissolve the precipitated P and make it reavailable to microbes.


Acknowledgments Introduction Part 1 1. Cultural Excursions: Museums, Art Galleries, and Libraries in a Transatlantic World 2. Heavy Luggage: The Intercultural Transfer of Models for Social Housing Enterprises Part 2 3. How to Become a Gentleman: Philanthropy and Social Climbing 4. Bountiful Ladies: Philanthropy and Women's Place in Society 5. Giving for Good: Philanthropy and Religion Conclusion Notes Index


In this paper, the optimum condition of enzymatic hydrolysis of tea-seed protein was studied. The results showed that 2709 alkaline protease was the best enzyme, the optimum hydrolysis condition for preparation of tea-seed peptides was pH 8.0, [E]/[S] 10 %, temperature 45 ℃ and time 5 h, and the DH was 34.64 % under this condition. The tea-seed peptides produced under this condition exhibited strong scavenging activity to O2-· and ·OH.


Bodybuilding is the most effective sports event exercising the muscles. The research shows that bodybuilding has a very strict demand for food and drink. Scientific arrangement and absorption of the nutrition in food plays an important role for the college students keeping fit,(improving) their health and perfecting their body shape. Therefore,setting up a nutrient,sanitary,scientific and reasonable diet structure is the necessary condition for the students keeping fit,(producing) muscle and making themselves strong and fit.


The observation of homoclinic linkage in the double-scroll circuit is reported. Different homoclinicities are linked together via the same periodic orbit. A discussion of the Shilnikov condition is presented.<<ETX>>


Government Strategy In Unemployment Decreasesin District Handsome Pekanbaru. This study aimstoreducethe unemployment rateinthe cityof Pekanbaru, especially in District Handsome. This studyis descriptive equalitative wheredata collection is donebysnowball sampling technique. The results ofthis study indicatethatit is not the maximum execution Unemployment Decreasesin District Handsome Pekanbaru. Minimizeun employment in the District Handsome Pekanbaruhas not gone wellin implementingefforts toreduceun employment. Indicatorof the weaknessandthe threat ofjob seekersmostjob seekersfresh outof schoolanddo nothave the skills and expertise. Then the job seekersdo not want to fill jobsoutside the area. Andalsojob seekers who come from outside the areais alsobecomingone of the problemsthat hinderthe governmentin reducing unemployment ratein the Distric tHandsome Pekanbaru. Keywords:Strategy, Unemployment, Strengths, Weaknesses, Opportunities, Threats


San Francisco-based  Skillz, a provider of a sports tournament mobile gaming platform, announced it has raised $15 million in Series B funding led by David Bonderman's Wildcat Capital Management. Other investors include The Kraft Group (owner of the New...


Auto ultrasonic flaw classification is the hotspot of nondestructive evaluation(UDE).A modified Morlet wavelet(MMW)was adopted to denoise the ultrasonic signal.To gain more characteristics of the ultrasonic signal,the eigenvector of the flaw was constructed based on the parameter structure.The eigenvectors were inputted into RBF for flaw classification.The testing results prove the validity of MMW in improving the signal-noise ratio and the comprehensive characteristics are propitious to flaw classification,and the intercommunities of congeneric flaws are acquired and the veracity of flaw classification is improved with RBF.


Anemia causes many complications, which include fatigue, dementia, and decreased mobility and life quality. It also results in higher mortality rates by inducing chronic diseases, such as heart and kidney failure.9,10 Anemia has a negative effect on cognitive performance in adolescents.11 Also, iron deficiency leads to cell cycle arrest and even cell death.12,13 Dysregulation of iron homeostasis may cause hematological, metabolic, and neurological diseases. In recent years, the correlation between bone metabolism and iron is the focus of research.14 Also, iron metabolism is implicated in the incidence of diabetes and associated atherosclerotic disease.15,16 This causative relationship is underlined by reports of an improvement of glycemic control in response to a reduction in body iron.17 It also influences the development of vascular disease.18 Anemia can also result in adverse pregnancy outcomes or even maternal death, as well as reduced work productivity and impaired physical capabilities.19


As I watch a plethora of excruciating performances and eardrum-perforating screeches in the Britain's Got Talent or The X Factor auditions I wonder: "Don't these people have friends?" Was no-one able to speak some truth-in-love and convince them at an earlier stage to explore other avenues in life?


The invention discloses a manufacture method of a reversible bonding micro-fluidic chip with high strength. The manufacture method includes using a sacrificial layer mold to manufacture and integrating a polydimethylsiloxane (PDMS) membrane of a micro pipeline structure firstly, aligning and attaching a structure face of the PDMS membrane to a pre-punched rigid substrate, then attaching the other rigid substrate with PDMS pre-polymer and curing agent mixed liquor coated in spin mode in advance to the back of the PDMS membrane, then solidifying to obtain a completely seamless attached substrate-PDMS-substrate sandwich type micro-fluidic chip, and finally, clamping two rigid substrates of the sandwich type micro fluidic chip from the upper and lower faces by using a clamp, and therefore the ability of tolerating applied pressure intensity of the micro pipeline structure of the sandwich type micro-fluidic chip is enhanced. The sandwich type micro-fluidic chip of a combination clamp simultaneously has superiorities of assembling reversibly and resisting high pressure, broadens the applied range of the reversible bonding micro-fluidic chip greatly, and reduces application cost of the micro-fluidic chip.


In a dense urban area, conventional cellular V2X communications require frequent and heavy resource allocation, which can lead to processing congestion and large delay. In this paper, we propose a semi- persistent resource allocation scheme using the least minimum mean square error (LMMSE) traffic prediction in a two-tier network. The two-tier network architecture includes a central macro base station (MBS) and multiple roadside units (RSU). In the proposed scheme, the MBS pre-allocates persistent resource to RSUs based on predicted traffic, and then allocate dynamic resource upon real-time requests from vehicles through RSUs. We formulate an optimization problem for minimizing the total bandwidth under latency constraints and provide an optimal solution to the problem. Simulation is conducted for both artificially generated and real-world data, and the results validate the effectiveness of the proposed semi- persistent scheme.


A B S T R A C T Data mining is used for various ways like government sectors, private sectors eg. Banking, Research center. Data mining is the classification process. Now a days, due to the growth of Internet various privacy issues arise. In classification problem different security model will be prepared. Now a days, due to the growth of cloud computing, user can outsource their data on cloud in encrypted form and can apply data mining tasks on cloud. In data mining privacypreserving classification technique are not applicable. So, in our paper we are solving the privacypreserving classification problem over encrypted data. We are using k-NN classifier technique over encrypted data in cloud. The proposed system provides-Confidentiality of data, Privacy of user input query, Hides data access patterns


The effect of intense ultraviolet-pumping radiation upon the energy output of a ruby laser has been investigated. This study has been stimulated by recent interest in extremely high-power pumping of ruby lasers. Conventional xenon flashlamps are relatively good blackbody radiators over a considerable part of the visible and infrared spectrum. When their power output is increased by higher current operation, it must come chiefly by raising the effective temperature, as well as by increasing the violet and ultraviolet opacity. As the temperature of a