The results of laboratorial and instrumental (multispiral computed coronarography, cycle ergometry) investigations with estimation of catecholamines level in blood were analyzed with the purpose of studying the peculiarities of IHD detection and characteristic features of the course of this disease at patients abusing alcohol. The incidence of effort angina of high functional classes was authentically lower at patients abusing alcohol, while the incidence of myocardial infarction, especially with Q-wave, at these patients was twice as high as among people who didn't have alcohol abuse. Multispiral computed coronarography showed high correlation between Agatston calcium score and effort angina of high functional classes as well as myocardial infarctions at patients of the control group and less expressed changes of coronary arteries at patients with myocardial infarction abusing alcohol at whom it became a manifest form of IHD. Thus, diagnostic consideration of clinical observations and instrumental methods of investigations in IHD verification and risk determination of unfavorable course of the disease is lower at patients abusing alcohol then at patients of the control group. This can be explained by the negative influence of alcohol on metabolic processes in a human organism.


The present invention provides a method of achieving both the oxidation of the desired and introduced into the oxidation reactor as a gas stream comprising an oxidation catalyst comprising an organic compound with sufficient oxygen present invention relates to a process for the oxidation of the organic compounds contained in the gas stream and oxidizing to achieve a sufficient temperature, and comprising the step of maintaining the temperature of the gas flow, an oxidation catalyst is characterized in that it comprises ruthenium, cobalt or manganese 0.01% by weight or more.


The utility model discloses a single-track driving electric gate valve, which comprises a valve seat, a valve body and an insert plate performing reciprocating movement between the vale seat and the valve body, wherein a torque motor is fixed on the valve body; the torque motor is in mechanical joint with and drives a gear; the gear is meshed with and drives a transmission tooth rack; and the transmission tooth rack is accommodated in a guiding groove arranged on the valve body, is connected with the insert plate and drives the insert plate to perform reciprocating movement along the guiding groove. The gate vale adopts the gear and the tooth rack for transmission, can be opened and closed quickly, and meets the requirement of a system for the opening and closing time of the gate valve; as the torque motor is adopted, the gate valve has fast response and strong overload capacity, and the motor can perform rotation stop as the motor has the self-protection function; and the equipment has the advantages of compact structure, light weight and small volume, and can be installed and maintained very conveniently.


The paper proposes a new version of local tangent space alignment(LTSA),named multi-strategies upgraded local tangent space alignment(MSU-LTSA),to solve the problem of computational complexity in dimensionality reduction of hyperspectral imagery(HSI)for classification. First,random projection is introduced into the new method to reduce the number of HSI bands. That decreases the computational complexity of k-nearest neighbors(KNNs) construction and local tangent space construction of each pixel. Then,the recursive lanczos bisection algorithm is utilized to construct the fast approximate KNNs graph and it reduces the computational time of regular approach. Finally, when finishing constructing the global alignment matrix,the new method uses the fast approximate singular value decomposition to promote the computational speed of the regular eigenvalue decomposition of global alignment matrix.With two different HSI datasets,four groups of experiments are designed to completely analyze and testify the performance of computation and classification for MSU-LTSA.The results show that MSU-LTSA speeds up LTSA at least 3 times whereas only degrading about 1% in its overall classification accuracy(OCA).


Egg Production Character Evaluation And Heavy Local Chicken's Egg At East Nusa Tenggara . The experiment about genetic potential evaluation for the characteristics of egg production and egg weight of local chickens in East Nusa Tenggara has been conducted in animal production housing Animal husbandry department, Polytechnic of Agriculture Kupang. The objective of this study is determine the genetic potency of local chicken in terms of their egg production, heritability value of egg production characteristic and egg weight of local chicken in East Nusa Tenggara. Randomized complete block design was applied in this experiment by using Anova of heritability. The results show that the average of egg production of local chicken is 60,67% ± 2.5, white the egg weight is 0,38 (38%) ± 2,8. These findings show that local chicken has genetic potency for egg production which is above egg production average (60%) and egg weight is categorized as medium egg weight with (heritability value 0-1). The big standard deviation is probably due to the big variation of local chicken variety and their genetics that are needed to develop. In conclusion, local chicken in East Nusa Tenggara has genetic potency to be developed because of their heritability value of egg production which is above the egg production average and their egg weight is medium. Keywords: Local chicken, heretability value, egg production and egg weight


The State of Florida has been pursuing the planning and implementation of high speed rail in the Miami-Orlando-Tampa corridor for the past ten years. Due to financial and institutional constraints, it may be difficult to implement the entire project under one phase. This paper investigates the potential for the segmental implementation of the Orlando-Tampa segment as a first-phase of a statewide high speed rail system.


The eighteen amino acids were determined by microbiological analysis on proteins, namely, albumin, globulin, prolamin and glutelin, obtained from the seeds of oat and ragi belonging to family Gramineae. The protein fractions were found to differ from each other in their amino acid composition. Especially prolamin contained more glutamic acid, leucine and proline and less glycine, aspartic acid, lysine and arginine than those in other protein fractions. When compared oat belonging to subfamily Pooideae with ragi to subfamily Eragrostoideae in amino acid content of prolamin, the latter was high in alanine, aspartic acid, histidine, tyrosine, serine and threonine and low in basic amino acids and cystine. However, albumin, globulin and glutelin gave no remarkable difference in amino acid composition between the two cereals.


ABSTRACT How do students use religious faith to inform their actions in competitive sport? This qualitative study critically reflects on this question based upon the thinking processes and experiences of 15-year-old participants in sports and, in turn, produces a basic conceptual framework toward the question at hand. Overall, students reported a complex, competitive environment where they integrate, overlook, and avoid their faith as a means to inform their competitive drive in sport. Despite these mixed results and the dangers of aggressive sport, this paper concludes that Christian schools would be unwise to restrict support to only angelic sporting events and instead should, among several suggestions, incorporate insight from health standards, reconsider the use of prayer, and think about improved educational prescriptions.


Synthetic esters have extensively been studied and utilizeel as the jet engine oils. The earliest practical use of the synthetic esters was the diester type such as DOS. The diesters have excellent physical properties, but some are not very stable for heat. A particular type in which β-carbon of alcohol moiety is quarternary, is called a "hindered ester", which shows an improved thermal stability over those having non-quarternary β-carbon, Polyols such as trimethylolpropane, pentaerythritol etc., give the type of esters with carboxylic acids. The thermal stability is further improved by employing an acid having a quarternary α-carbon; the resultant ester is often referred to as a "neoacid ester". The neoacid ester, however, exhibits not better pbysical properties than the diesters and hindered esterss especially on the viscosity-temperature characteristics, low temperature fluidity and volatility. There are some other esters; fluorinated esters, oxidatively autoinhivitive esters, etc.


The structure–property evolution of commercial poly(ethylene terephthalate) (PET) fibers obtained from the different drawing and heat-setting stages in industrial processing was systematically investigated. Upon combination of thermal analysis (DSC and DMA) with crystallization and orientation (WAXD and SAXS), the variation of crystallization and microstructures mainly containing lamellar and microfibrillar crystals following the processes were discussed in connection with properties. Results indicate the significant tenacity increase of fiber in the drawing process is mainly attributed to the orientation development of the interlamellar amorphous region, the interfibrillar extension of amorphous molecular chains, and its entanglement with the lamellae. Accordingly, a decline of shrinkage can be seen as a fact of the coiling of amorphous molecular chains, the formation of rigid amorphous fraction, and the increase of crystallinity. Thus, a new four-phase model has been proposed to clarify the structure–pr...


There is, thoughtful students agree, no entirely satisfactory interpretation of quantum mechanics. Jeremy Bernstein examines John Bell's discontent with the standard formulations of quantum mechanics.


Although whole-body vibration (WBV) combined with static stretching (SS) have proven a suitable method to enhance flexibility without losing muscular strength, it is still unknown what its effect are on running mechanics. Therefore, the purpose of the study was to examine the effect of a WBV combined with SS (WBVSS) warm up procedure on lower limb stiffness and spatiotemporal variables during running. Twenty-two female gymnasts performed 30-s running bouts at 4.44 m.s-1 on a treadmill before and after a WBVSS intervention stimulus. The WBVSS stimulus included two sets of 20s of SS of four different muscle groups on the vibration platform. Leg and vertical stiffness values were calculated using a spring mass model. The results showed a statistically significant interaction effect on vertical stiffness (Kvert), leg stiffness (Kleg), change in leg length (ΔL), maximal ground reaction force (Fmax), contact time (Tc), and flight time (Tf). Results indicated that, a warm-up including SS combined with WBV did not produce significant effect on mean values of Kleg and Kvert, and related kinetic and kinematic variables.  Article visualizations:


Accurate modeling of melting and solidification processes is important to many engineering applications. The research presented in this article is part of an ongoing effort to document the melting behavior of lauric acid in a 50 mm by 120 mm rectangular container with an isothermal side—an experiment commonly used to validate numerical models. This article presents new experimental data of melting occurring at 135 deg and 180 deg inclines for isothermal wall temperatures of 60∘C and 70∘C. The data were processed to show the melt interface development and the melt fraction as a function of time. Furthermore, numerical simulations using the enthalpy-porosity method of the 135 deg incline were also conducted. In the numerical simulations, the mushy zone constant was parametrically varied. Different density approaches commonly found in the literature (e.g., density as a function of temperature or Boussinesq approximation) were utilized and examined. It was found that the choice of density method had a significant effect on the results. Implications of potential modeling choices unique to the enthalpy-porosity method are discussed related to the validation of models.


This article explains how businesses can use a widely available, low-cost technology to protect their employees from Covid-19 as they return to work. The proposed approach encompasses the need for ...


Melody has been a suspect word for a long time. It has a bland, watery sound: mehdy is Bellini, music is Beethoven; mehdy is Irving Berlin, music is Schoenberg. Even in the world of Italian opera, where it seems to reign supreme, there is a certain distrust of melody. When Verdi was advising die prima donna of his ambitious new opera Macbeth (1847) on how to sing the sleepwalking scene, he told her, "Everything is to be said sotto voce and in such a way as to arouse terror and pity. Study it well and you will see diat you can make an effect with it, even if it lacks one of those flowing, conventional melodies [canti fihti, e soliti], which can be found everywhere and which are all alike." No one, it seems, wants to be a mere tunesmith. In the domain of poetry, too, if you write flowing, conventional melodies, you're usually not doing too well. Though he doesn't refer to them as such, Northrop Frye is clearly thinking of diese melodies when he writes, "Musical usually means 'sounding nice.'... The term musical as ordinarily used is a value term meaning that the poet has produced a pleasant variety of vowel sounds and has managed to avoid the more unpronounceable clusters of consonants that abound in modern English. If he does this, he is musical, whedier or not he knows a whole note from a half rest." The poetics of Modernism valued music highly, but only insofar as the music had a certain strangeness to it. One of the tenets of Pound's Imagism was "As regarding rhyriim: to compose in the sequence of the musical phrase, not in sequence of a metronome." This is in some ways an unremarkable wish: A hundred years before Pound's time, Keats had been equally eager to emancipate poetry from the tick-tock of Pope's rhythm: a sc[h]ism Nurtured by foppery and barbarism, Made great Apollo blush for this his land. Men were thought wise who could not understand His glories: with a puling infant's force They sway'd about upon a rocking horse, And thought it Pegasus. ("Sleep and Poetry") Keats of course is writing in heroic couplets, Pope's own favorite verse form, but the caesura doesn't mechanically alternate (as Pope's caesuras tend to do) between the fourdi syllable of die line and the sixth; Keats puts the caesura in some quite odd places, even in the middle of a foot ("His glories: I with a puling infant's force"). Keats might not have liked Pound's verse, if he'd lived to read it, but I doubt that he would have quarreled strongly with die third tenet of Imagism. Still, there is a certain radicalism in Pound's dogma. The metronome was an object of fun even when it first appeared - Beethoven wrote a little spoof about Johann Nepomuk Maltzel, its inventor, a canon with a springy tune familiar from the tick-tock movement in the eighth symphony. And it is a commonplace to observe that music gets its life from agogics, rubato, hesitations, accelerations, slight vertical miscoordinations - all sorts of deviances from the notated rhythm. But to say that music might be defined as the anti-metronomical is to go much farther than just about anyone in the nineteenth century would have gone. Pound dreamed of a poetic music that was sinewy, sinuous, an unmetered riff - "To break the pentameter, that was die first heave," he tells us in Canto LXXXI. But to some extent this battle had been fought and won long before the Modernists came onto the scene. Consider the beginning of Whitman's late poem "Patroling Barnegat" (1880): Wild, wild the storm, and the sea high running, Steady the roar of the gale, with incessant undertone muttering, Shouts of demoniac laughter fitfully piercing and pealing, Waves, air, midnight, their savagest trinity lashing, Out in the shadows there milk-white combs careering, On beachy slush and sand spirts of snow fierce slanting, Where through the murk the easterly death-wind breasting. …


Typical real world machine control tasks have some characteristics which makes them difficult to solve: Their state spaces are high-dimensional and continuous, and it may be impossible to reach a satisfying target state by exploration or human control. To overcome these problems, in this paper, we propose (1) to use radial basis functions for value function approximation in continuous space reinforcement learning and (2) the use of learned inverse projection functions for state space exploration. We apply our approach to path planning in dynamic environments and to an aircraft autolanding simulation, and evaluate its performance.


Abstract The problem of estimating the separation characteristics, including mass yield, partition curve, cut point (dp ) probable error (Ep and error area (Ap ) from mass distributions of feed and products is considered. A graphical technique previously proposed is modified and extended to estimate the separation characteristics. It is demonstrated that the mass distributions of feed and products could be used to estimate the separation characteristics of the separator. Two-product and three-product separation cases are considered. The proposed techniques can handle both density and sin separation. Actual data are utilized to demonstrate the effectiveness of the proposed techniques.


In November 1986, joint radar and Na lidar observations were conducted in Colorado to study mesopause dynamics. The radar observations were conducted at Platteville, Colorado with a Stratosphere Troposphere (ST) radar in a meteor echo detection mode. The Na lidar observations included ground-based observations at Broomfield and Denver, Colorado, and airbome observations during three flights over the Great Plains, Rocky Mountains, and Pacific Coast. Both radar and lidar identified a 6-hour wave that was remarkably coherent during the November campaign. The vertical wavelength of the 6-hour wave estimated from the radar data was 8 to 9 km, the amplitude of the zonal wind component was 10 m S−1, and the amplitude of the meridional wind component was 4 m s−1. The vertical wavelength estimated from the ground-based and airborne lidar data was 7.3 km, and the amplitude of the scalar horizontal wind ranged from 13 to 16 m s−1. The zonal wavelength of this wave was approximately 772 km, and the intrinsic zonal phase velocity was 35 m s−1 westward. The 6-hour wave was dominant in the height range of 80–90 km, which corresponds to the bottomside of the Na layer. An additional 2-hour wave was observed with the Na lidar during both the ground-based and airborne observations. The vertical wavelength of this wave was about 12 km, and the zonal wavelength was 260 km. The intrinsic zonal phase velocity was 43 m s−1 westward. This 2-hour wave was also present only on the bottomside of the Na layer.


The management of the clinically N0 (cN0) neck is controversial for early stage squamous cell carcinoma of the oral cavity (OSCC). This paper represents a single institution series analyzing the efficacy of sentinel lymph node biopsy (SNB) for early stage oral cavity cancers.


The Bauru radar detects inner cores of deep convective storm cells at long range, but relevant cell areas are left undetected. A procedure is in development to generate a more complete three‐dimensional representation of the cell structure for cost‐beneficial hydrological use at larger distances. A set of satellite microwave brightness temperature (Tb)—radar reflectivity (Z) relationships, basic to the retrieval procedure, has been derived. Copyright © 2005 Royal Meteorological Society


Among the nuclear analytical methods that have proved very useful in biological and medical analyses is the in vivo prompt gamma neutron activation analysis (IVPGAA). In this work, an IVPGAA facility was assembled on a zero-power mobile nuclear reactor and has demonstrated its versatility for in vivo medical diagnosis. Absolute measurements of some environmental contaminants such as Cd, Hg, and Si in organs can be determined rapidly by partial body scan of IVPGAA, while assessment of vital constituents such as Ca, Cl, N, and P in either whole body or body part can be scanned by IVPGAA technique effectively. The in vivo clinical application using mobile reactor neutron beam are reviewed in detail. The IVPGAA scan provides unique insight into elemental concentration purposes. The IVPGAA scan can be performed on a regular basis without discomfort and radiation risk for patients.


Aiming at the problem that the traditional teaching mode takes teachers as the center, students lack the ability of active learning and flexible application. According to the characteristics of online teaching, this paper applies the BOPPPS model to Rain Class integrating Ding talk, Wechat group and XuetangX platform. The organization methods of bridge-in, learning objective, pre-assessment, participatory-larning, post-assessment, and summary are designed elaborately. The practice shows that under the background of online teaching, the teaching mode proposed in this paper improves the students' initiative in learning the course of "Systems engineering" and achieves the ideal teaching effect.


in the age 'group 40 to 49, and the males 60 to 69; but no adult age is exempt. It has been suggested that disturbances of the endocrine glands may play a part in the development of this disorder, and the difference in age incidence in the sexes may be thus explained. Hormonal conditions may have a dominating part. In a female granulocytopenia corresponded to the first day of each menstrual epoch. In a male there was a rise of the granulocytic count after thyreoid administration. It is unlikely that intolerance can be certainly established by blood examination after one dose. Possibly an allergic condition may develop later. We do not know whether some individuals are permanently hypersensitive or are only so at certain times. Kracke and Parker, as stated in our previous reference to this subject, presuppose the existence of a previously weakened, damaged or idiosyncratic bone marrow. Patients may suddenly manifest agranulocytosis after amidopyrine, although they have had such drug previously without subjective discomfort. Cutaneous tests have given no reaction and amidopyrine may cause a rash without change in the blood picture. Combined hremotoxicoses, including leucopenia. thrombopenia and anremia, have been described after the administration of arsenobenzol, gold preparations and benzol. Pure agranulocytosis has followed arsenobenzol alone or with bismuth or mercury; or gold or dinitrophenol. The few cases ascribed to phenazone are doubtful. Plum concludes that, in view of the extensive USe of amidopyrine, comparatively few persons are hypersensitive to it. as is the case with neosalvarsan, "Atophan" and "Sanocrysin"; but he has no doubt that deaths due to amidopyrine are commoner than those resulting from any other drug, apart from suicide or accidental overdosage. In these circumstances there would seem to be no reason for retaining this preparation in the pharmacopreias. Its benefits can be obtained by more innocent compounds.


Even with all the technological advancements today, imaging the fractured basement in onshore datasets remains challenging. There are several factors contributing to the complexity, such as erratic topography that introduces static errors, unconsolidated surfaces that absorb the emitted energy and prevent it from propagating through the subsurface, several high amplitude hard surfaces that create interbed multiples throughout the section, and the presence of shallow gas pockets that introduce unnatural sagging. On top of these geological heterogeneities of overburden, imaging the fractured basement in onshore data suffers from sparsity of seismic acquisition due to limitations in land accessibility; this issue is absent in offshore seismic surveys. The success of imaging the onshore fractured basement largely depends on the detailed work of seismic data preconditioning and the velocity model building conducted by an experienced team. This paper showcases a case study of seismic processing and imaging of land data with a deep target, including the fractured basement target. Firstly, analysis was done on the legacy dataset to highlight the imaging ambiguity, and secondly, a solution was proposed for a systematic and sequential workflow of seismic reprocessing. The findings and observations of the seismic processing products are shared in this paper.


Advances in the scientific and commercial sectors have leapt ahead of conventional building system construction techniques. However, recent breakthroughs in information technology including high speed computers have enabled design engineers to develop efficient facilities that will permit corporations and institutions to keep abreast of the business environment projected for the twenty-first century. The advances in design technology must include the integration of sophisticated quality control methods as part of this process, and an overview is presented of computer based methods for quality control for use with these new digital tools. New digital tools include the computer charrette, computer optimization and integrated computer design required for the new generation of smart structures. This overview emphasizes the growing reliance on computers and outlines caveats that will help avoid misuse of information technology through believed dependence on computers that can lead to fatal errors. The aerospac...


Chymosin is one of the enzymes with many applications in the food industry. Its recombinant type has been designed and constructed in different forms. In this investigation, the production efficiency of two types of complete and exon-6 less prochymosin was assessed. It was found that the average efficiencies of the optimum growth conditions calculated for the two constructs harbouring pET-prochymosin and pET-exon-6 less prochymosin were significantly different (P value <0.05) at 192.02 ± 3.57 and 348.87 ± 7.76, respectively. Also during fermentation, the level of the exon-6 less prochymosin production was much higher than the other construct as demonstrated by SDS-PAGE.


The ionic transport in a series of 0.2 [X Na2O·(1 − X)Rb2O]·0.8B2O3 glasses has been studied by measuring both the electrical conductivity of these glasses and the tracer diffusivities of 22Na and 86Rb as functions of composition and temperature. At constant temperature (380 °C) the tracer diffusivities of 22Na and 86Rb decrease monotonically with decreasing Na- or Rb-content, respectively. The tracer diffusivities as functions of the composition parameter X intersect near X = 0.2 ('crossover composition'). This behaviour gives rise to a minimum in the conductivity which appears near X = 0.4. At the crossover composition X = 0.2 the diffusivities of 22Na and 86Rb are practically the same within the measured temperature range resulting in similar Arrhenius parameters. For each other investigated composition the Arrhenius parameters for 22Na and 86Rb diffusion differ significantly. Comparing the 22Na-diffusivity in the pure Na-borate glass with the corresponding conductivity diffusion coefficient calculated via the Nernst–Einstein equation from the measured conductivity yields a temperature-independent Haven ratio. In contrast, a temperature-dependent Haven ratio was found in the pure Rb-borate glass. In order to compare the tracer diffusivities in mixed-alkali glasses with their ionic conductivity we introduce a 'common Haven ratio' for the mixed-alkali glasses which coincides with the conventional definition of the Haven ratio for single-alkali glasses. On the Rb-rich side the common Haven ratio decreases with temperature for Na–Rb borate glasses (X = 0.2 and X = 0.4) similar to the Haven ratio in the pure Rb borate glass.


The school environment, which includes the classroom, school location, school facility, school climate and technology, etc, is a variable that affects students' academic performance. Hence the school environment remains an important area that should be studied and well managed to enhance students' academic performance. The extent to which students' learning could be enhanced depends on their location within the school compound, the structure of their classroom, availability of instructional facilities and accessories. It is believed that a well planned school will gear up expected outcome of education that will facilitate good social, political and economic emancipation, effective teaching learning process and academic performance of the students.


Computer-aided diagnosis (CAD) system can assistant radiologists to diagnose bone metastasis, which not only reduces burden on workload but also improves diagnostic accuracy. As key step in CAD system, vertebral segmentation can directly affect diagnostic results. In order to obtain high accurate segmentation results, we propose a connected component Labeled Graph Cuts (LGC) algorithm. The proposed method is tested on 100 computed tomography (CT) slices. The assessed quantitatively of experimental results is compared with those by radiologist. The proposed method has a 96.72[%] of True Positive Rate (TPR), and 1.84[%] of False Positive Rate (FPR), which have better performance than conventional Graph Cuts algorithm, 90.07[%] of TPR and 2.32[%] of FPR.


Species abundance distribution,reflecting the information of the community structure,is one of the important parts in biodiversity research.Six typical meadow communities(Carex enervis,Carex dahurica,Eleocharis intersita,Leontopodium longifolium,Ligularia sagitta and Saussures acuminata) and patched meadow communities(hummocks and hollows) were selected in riparian area of Xilin River,Inner Mongolia,China.Abundance distribution patterns of the wetland species were simulated at both log-abundance-specie-rank order and specie-octave levels using five models,Lornormal,Logseries,Weibull,Exponent and Power model.According to the occurrence frequencies in the communities,species were identified as frequent species,transitional species and occasional species to analysis the species abundance patterns.The results showed that while none of the models had fitted well for the wetland communities in the log-abundance-specie-rank order levels,frequent species,occasional species and transitional species in typical meadows were fitted by Weibull,Power and Logseires models respectively,and the frequent and occasional species in patched meadows could be simulated by Logserie and Power models.On the specie-octave level,however,five models had worked well.The K-S test results showed that Carex dahurica,Carex enervis,and Eleocharis intersita community were fitted well by Lognormal model.Leontopodium longifolium,and Saussures acuminate community were fitted by Weibull model,and Ligularia sagitta by Power model.The different simulation results suggested rich diversity and complex community structure in the wetland.Communities in typical meadows were related to those in patched meadows by the similar species.


'Letting It Lie' is a three part television drama series that explores the pressures of modern society and the subsequent issues of control that follow. When Leila Mellor goes against her husband Rob's wishes and signs them both up for significant medical tests, she realises that the more she tries to hold her family together the further apart they become.

The key theme of Letting It Lie is the dilemma of the modern woman and trying to be everything to all people. This situation is clearly not unique to women however they are often expected to keep more balls in the air than their male counterparts. Leila is juggling a demanding, high-pressure career with the desire to be a good mother, manage the household and repair her relationship. This 'mental load' constitutes normal life for many women and the concept of having time to oneself or a spare moment during the day in which to sit down and switch off, is alien. Often, something has to give – be it health, relationships or mental well-being and life can become overwhelming. Unfortunately for Leila and her family, the effect of such pressure is life-threatening.

This series explores a very modern, serious and universal dilemma with warmth, humour and heart.


This paper examines the joint impact of different governance mechanisms on firm performance. We use three proxies for firm performance: Tobin's Q, ROA, and the Fama-French-Carhart Alpha. We employ a large panel data set and specify a simultaneous equations model with empirically validated strong instrumental variables to control for endogeneity and unobserved firm-level heterogeneity. Consistent with the interpretation that firms are in equilibrium, we find that firm performance is unrelated to CEO compensation-performance sensitivity, institutional shareholdings, corporate control variables, and CEO turnover. We find that firms are not in equilibrium with respect to board independence, as increasing board independence results in increases in firm performance (when proxied by Tobin's Q and ROA). No such result is found for Alpha. All three performance measures show a negative relationship between leverage and firm performance. One might interpret this result to indicate that firms are over-leveraged or that good (more profitable) firms rely less on external financing and use retained earnings as their primary source of financing, consistent with the pecking order theory of Myers (1984) and Myers and Majluf (1984). We also find that there is an inter-relationship between the different governance mechanisms. ________________________________________________________________________________________ Rutgers Business School, Rutgers Business School and Princeton University, and Manhattan College, respectively. We thank N. Chidambaran, Bill Greene, Kose John, Ayla Kayhan, Simi Kedia, Ken Lehn, Mike Long, Brian Poi, Avri Ravid, John Wald, and seminar participants of the 2002 Financial Management Association Meetings, 2006 American Finance Association Meetings, Villanova, and Wilfred Lauirier for helpful comments. Partial financial support from the David K. Whitcomb Center for Research in Financial Services is gratefully acknowledged. An earlier version of the paper was titled Simultaneous Estimation of CEO Compensation, Leverage and Board Characteristics on Firm Value. All errors remain our responsibility. Corresponding author: Darius Palia; firstname.lastname@example.com


The Treasury will have the final say on whether to implement the new unsocial hours payments scheme, which is still being thrashed out by NHS Employers and nursing unions.


Filtration rate values with neutral red were analyzed in 60 mangrove oysters, Crassostrea rhizophorae , in two experiments; one with salinities of 10, 20, 25, 30 and 35 o / oo at a constant 24°C temperature and the other with temperatures of 24, 28, 32 and 34°C at a cunstant 25 o / oo salinity. The optimal filtration rate occurred at a 25 o / oo salinity and a 28°C temperature.


A hydrophilic cross-linked polymer obtainable by copolymerisation of hydrophobic and hydrophilic monomers that give a cross-linked hydrophilic polymer on polymerisation; a monomer including a strongly ionic group; and water is useful as the membrane in an assembly that can be used in an electrolyter or fuel cell. More generally, a membrane electrode assembly comprises electrodes and an ion-exchange membrane which comprises a hydrophilic polymer including a strongly ionic group. A method for producing a membrane electrode assembly comprising electrodes and an ion-exchange membrane, comprises introducing between the electrodes a material or materials from which the membrane can be formed, and forming the membrane in situ.


The author has produced a media presentation to give student teachers an opportunity to see parent participation and involvement as positive approaches to improving teaching and learning in primary schools.


Ultrasonic absorption measurements have been used to study the dynamics of micellar systems and to obtain semiquantitative information on the kinetic and thermodynamic parameters for the cosurfactant exchange process from mixed micelles of surfactant and cosurfactant. Ultrasonic relaxation parameters for the micellar systems containing water, surfactant (cetyltrimethylammonium bromide, myristyltrimethylammonium bromide, cetylpyridinium bromide, and Dowfax 2A1), and cosurfactant (butoxyethanol) are reported. The kinetic parameters for the exchange of butoxyethanol between the mixed micelles containing cetyltrimethylammonium bromide and myristyltrimethylammonium bromide are estimated and the results are discussed in light of the proposed mechanism.


Alternative beta refers to risk factors that are available beyond traditional long only equity and fixed income investments. In this paper, we analyse multi-asset trend, carry, and volatility returns, explaining why they exist, the benefits they confer to a traditional balanced portfolio, and the risks. The benefits of combining the three strategies are explored, along with how they have fared recently in markets dominated by central bank intervention. Our results show that adding multi-asset alternative beta strategies to a balanced portfolio, either singularly or as a group, leads to significant enhancements in terms of improved returns, lower volatility, and lower drawdowns.


Infarct size and extent of transmural involvement are major determinants of left ventricular (LV) remodeling after myocardial infarction (MI), and restoration of the patency of the coronary artery alone remains the most important intervention to limit the extent of myocardial injury.1 Noninvasive imaging modalities, such as contrast echocardiography2 and cardiac magnetic resonance imaging,3 have shown that the integrity of microvasculature early on determines the viability of the myocardium in the area at risk.4 On the other hand, the extent of microvascular damage, persistent microvascular occlusion (PMO), and myocardial hemorrhage resulting from ischemia and reperfusion have been shown to adversely influence LV remodeling after MI regardless of the size of the infarct.5 It has also been observed that the deposition of iron in myocardium after infarction is associated with adverse LV remodeling and electrical abnormalities.6 The mechanisms by which PMO and interstitial hemorrhage lead to adverse LV remodeling and cardiovascular outcomes are not well understood.

See Article by Kali et al

In this issue of Circulation: Cardiovascular Imaging , Kali et al7 investigated the possible relationship between PMO, the extent of crystalline iron deposition in the myocardium, and adverse LV remodeling. Their study included 33 canines, wherein the left anterior descending was occluded for 3 hours followed either by reperfusion (n=17) or permanent occlusion (n=16). Serial cardiac magnetic resonance imaging was performed in all animals on day 7 (acute phase) …


In paediatric literature, there are data, although limited, which indicate the presence of specificity in the two genders. In this work, we have reviewed the literature data regarding gender differences specific to some paediatric pathologies, comparing these data with those collected by Ospedale Pediatrico Bambino Gesù of Rome. For many infectious diseases, the incidence is greater in men; women develop both a greater and longer lasting humoral and cellmediated immunity response which protects from infections but exposes one to a greater risk of developing auto-immune and inflammatory pathologies. For many vaccines, a greater antibody response has been demonstrated in women. However women develop adverse effects more often and with greater intensity. The majority of auto-immune diseases show a gender-specific preponderance, in particular women show a significantly greater risk to develop these pathologies; the incidence in the two genders is more evident in adults, but it is also observed in paediatric age groups. The gender differences concern not only the response to infections, vaccines or immune dysregulation, but it may also involve other fields of medicine such as neuropsychiatry and orthopaedics.


There is proposed a process for the production of methanol from a feed stream rich in carbon dioxide, in which a feed stream rich in carbon dioxide is supplied to a methanation stage and is converted there with hydrogen to a stream rich in methane. Along with a feed stream rich in hydrocarbons, the same subsequently is converted to synthesis gas in a reforming stage, which synthesis gas subsequently is converted to the end product methanol. Advantageously, an existing prereforming stage is used as methanation stage.


This invention relates to a process for substantially reducing the backmixing or backflow of gases into metal heat treating furnaces by the use of a particular gas jet and a defined flow rate.


1. Seed dispersal is widely recognized to be of crucial importance in the ecology of plant communities, yet characterization of dispersal capacity rarely goes beyond two categories: 'good' and 'poor' dispersers, defined on the basis of dispersule morphology.

2. We describe a new apparatus which determines the rate of fall of seeds in air by detecting their passage through two fans of laser light.

3. This apparatus is able to measure rate of fall in smaller seeds than previously published methods and reveals that there is no justification for the arbitrary division of species into two wind dispersal categories.


We consider pseudodifferential equations of the form (*)where is an unbounded region in which has a smooth boundary and which is a conical set outside a sphere of sufficiently large radius. The symbol of the pseudodifferential operator is either a function which is continuous with respect to on , which is the extension of obtained by adding a point at infinity, or is a function having polynomial growth as . With respect to the symbol is bounded, satisfies certain smoothness conditions, and is not necessarily stabilized as .We study (*) in the Sobolev-Slobodeckiĭ functional spaces . Depending on , the equation (*) becomes a properly posed problem either with general boundary conditions or with additional potentials. For some we can regard (*) as an integral equation which needs no additional conditions.We will obtain necessary and sufficient conditions under which properly posed problems for the equation (*) will be Noetherian in the Sobolev-Slobodeckiĭ spaces.Bibliography 17 items.


The separation of oil from wheat germ by extracting with supercritical carbon dioxide (C02) is described. The solubility of wheat germ oil in supercritical C02 at 200 atm and 40°C was about 0.35 weight%. The effect of pressure on the extraction process with liquid or supercritical C02 was of great significance. On the other hand, the effect of temperature on the extraction process was small. Oil extracted with supercritical C02 was lighter in color and contained less phosphorus than that extracted with hexane. The contents of α- and β-tocopherol in the oil extracted with supercritical CO2. were comparable to those in the hexane-extracted oil


Soil erosion was happened caused by many factors, such as rainfall intensity, soil erodbility, steepness and length of slope, land cover, and conservation practices. In other case, the soil properties also influence the vulnerability of soil to be detached. This soil properties characteristics is classified as soil erodibility. Erodibility factor (K) from the Universal Soil Loss Equation (USLE) in this study was the result of soil erodibility estimation or soil capability to be dispersed by rain. K factor was affected by soil organic, soil permeability, soil structures, and soil textures. This study was contributed in Serang Watershed because of the main fuction of this watershed to supply water resources especially in Sermo Reservoir in Ngrancah Subwatershed. This reservoir was used to distribute water and irrigation to all Kulonprogo District and especially to keep the sustainability of sedimentation of soastal area di Glagah Beach. All of soil properties was collected in each landform of Serang Watershed and was analyzed by laboratory measurement. By using K factor formula, the K value can be estimated. Geographic Information System (GIS) tools were used to map and represent the spatial information of soil erodibility of Serang Watershed. The result of this study showed that the high value of K factor was distributed in the area which has genesis of structural, denudated structural, and sedimented denudational. Furthermore, this study can be strived to analyze soil erosion hazard which was influenced by soil erodibility.


This article investigates the opportunities and challenges of cybersecurity for information systems (IS) programs and proposes a curriculum structure of cybersecurity track for IS programs. The study has collected data from eighty-two course websites of thirteen institutions at the graduate level and sixteen institutions at the undergraduate level as well as twenty descriptions of cybersecurity jobs posted on the internet. The collected qualitative data has been analyzed from the from the perspective of IS education. The findings indicate that the topics of cybersecurity management and essential cybersecurity technology are relevant to the IS discipline. The article suggests that these topics can be the components of two cybersecurity courses offered by IS programs to meet the demands and challenges of cybersecurity.


BACKGROUND

The coenzyme NAD+ (nicotinamide adenine dinucleotide) is commonly used in biocatalytic oxidations catalysed by the enzyme alcohol dehydrogenase (ADH). As the price of the coenzyme NAD+ is extremely high, it is essential to regenerate the reduced form of the coenzyme back into the oxidized form. In this work the regeneration of the coenzyme NAD+ was carried out in a microreactor by reversible oxidation of ethanol to acetaldehyde with the ADH enzyme.

RESULTS

A 100% conversion of NADH was achieved for a residence time of just τ = 0.8 s when the concentration of acetaldehyde was in excess (ci,NADH = 5.5 mmol dm-3, ci,acetaldehyde = 44 mmol dm-3, γi,ADH = 0.2 g dm-3, 75 mmol dm-3 glycine-pyrophosphate buffer pH = 9; T = 25°C). A 2D mathematical model for the description and prediction of microreactor performance was developed. Model simulations were validated using data from independent experiments.

CONCLUSION

The high conversions that were obtained for short residence times mean that the microreactors can be considered as good and efficient methods for coenzyme regeneration. © 2013 Society of Chemical Industry


In this paper, two effective preprocessing techniques for clustering large-scale circuits are presented. These techniques can be performed before the general multilevel clustering to enhance the speed of the partitioning technique while preserving the solution quality. A "wrapped" version of hMETIS is implemented, in which the proposed techniques are applied as the preprocessing step. The empirical results on standard benchmark circuits show that the application of the proposed techniques improves the over all runtime by 30% and the partitioning results by 2%.


Part of this invention is generating a pilot channel signal which relates to a beacon device for a hard hand-off, it generates a pilot channel signal of the cell in which the particular target; Synchronization channel signal to generate a synchronization channel signal of the cell generating part; Paging channel signal generation unit generating a paging channel signal in the cell; And up-converter unit which modulates the signal generated by the pilot channel signal generation unit, a synchronization channel signal generating unit and a paging channel signal generation unit into a signal of a predetermined frequency band, a beacon device for a hard handoff comprising the relate to. Since the beacon device according to the present invention is a base station and independently generating a signal and, the pilot channel, as well as to generate all of the overhead channel signals, such as synchronization channels, paging channels, support more than one communication system, such as CDMA and EV-DO, unnecessarily It can be to achieve the same effect as install the hard handoff to the base station without having to install an expensive base stations and there is an advantage that can ensure the coverage of a wide range with low power consumption. Beacon, pilot channel, sync channel, paging channel, hand-off


The objective of the research is to find out the effectivess of the silent way in teachingplural nouns to the eight grade students of SMP Negeri 1 Rantepao This research held atSMP NEGERI 1 RANTEPAO''.North Toraja regency,.The population consists of the number of subjects was surveyed in the research andit is hoped the results can be generalized. The population of this research is theeighth grade students of SMP NEGERI 1 RANTEPAO' that consists of six classes.The numbers of students is 193.The samples of this research were a part of the grade students of SMP NEGERI 1RANTEPAO'. The number of sample is 30 students. The writer use cluster samplingto get the data. The instrument of this study is written testBased on the findings and discussions of the previous chapter, the writer concludethat the implementation of silent way in teaching plural nouns to the eighth gradestudents of SMP NEGERI 1 RANTEPAO' have a good score effective. This factis prove by the students have good score and classified as good score and theresult of post-test mean score which is higher than the mean score of pre-test.


State-Of-Charge (SOC) estimation for Valve-Regulated Lead-Acid (VRLA) battery is complicated by the switched linear nature of the underlying dynamics. A first principles nonlinear model is simplified to provide two switched linear models and linearized to produce charge, discharge, and averaged models. Luenberger and switched SOC estimators are developed based on these models and propogated using experimental data. The results show that estimation errors are halved by including switching in the observer design.Copyright © 2012 by ASME


In this paper, we present a novel method to detect and resolve motion conflicts in visual-inertial odometry. Recently, it has been common to integrate an IMU sensor with visual odometry in order to improve localization accuracy and robustness. However, when a disagreement between the two sensor modalities occurs, the localization accuracy reduces drastically and leads to irreversible errors. In such conditions, multiple motion estimates based on the set of observations used are possible. This creates a conflict (motion conflict) in determining which observations to use for accurate ego-motion estimation. Therefore, we present a method to detect motion conflicts based on per-frame positional estimate discrepancy and per-landmark reprojection errors. Additionally, we also present a method to resolve motion conflicts by eliminating inconsistent IMU and landmark measurements. Finally, we implement Motion Conflict aware Visual Inertial Odometry (MC-VIO) by combining both detection and resolution of motion conflicts. We perform quantitative and qualitative evaluation of MC-VIO on visually and inertially challenging datasets. Experimental results indicate that the MC-VIO algorithm reduces the increase in absolute trajectory error by 80% and the relative pose error by 60% for scenes with motion conflict, in comparison to the state-of-the-art reference VIO algorithm.


Considers changes in understanding and attitudes about lining over many years. The 1974 Greenwich meeting is seen as pivotal in questioning the routine practice at the time. Thanks to the innovative efforts of key figures in the field, a wide range of treatments are now available that involve minimal intervention. For example, the Tate Gallery in London uses the following: strip linings, loose linings, loose panel supports, stretcher bar linings, various moisture treatments, tear repair, deacidification, BEVA, sturgeon's glue and microclimates. The author also sees chemical treatments as promising: though irreversible, they could provide decades of protection for recent paintings in good condition. De-lining, however, can be far more complex and questionable.


The study of California's history has traditionally focused on men. Although women are half the population their stories are often marginalized or omitted from the curriculum taught in classrooms (Crocco, 1997). Teachers need to convey to their students a sense of the importance of women's contributions to California's history. As most teachers were never taught the history of California women and it is largely missing from the textbooks, they lack the necessary resources to implement a complete curriculum. The purpose of this project was to develop a teacher resource that would integrate women's history into the existing fourth grade curriculum in California. A comprehensive literature review that addresses issues related to sex equity in education, textbooks, and integrating women's history is also provided.


This paper proposes enhanced studies on a model consisting of a finite mixture framework of generalized linear models (GLMs) with gamma-distributed responses estimated using the Bayesian approach coupled with the Markov Chain Monte Carlo (MCMC) method. The log-link function, which relates the mean and linear predictors of the model, is implemented to ensure non-negative values of the predicted gamma-distributed responses. The simulation-based inferential processes related to the Bayesian-MCMC method is carried out using the Gibbs sampler algorithm. The performance of proposed model is conducted through two real data applications on the gross domestic product per capita at purchasing power parity and the annual household income per capita. Graphical posterior predictive checks are carried out to verify the adequacy of the fitted model for the observed data. The predictive accuracy of this model is compared with other Bayesian models using the widely applicable information criterion (WAIC). We find that the Bayesian mixture of GLMs with gamma-distributed responses performs properly when the appropriate prior distributions are applied and has better predictive accuracy than the Bayesian mixture of linear regression model and the Bayesian gamma regression model.


In order to expand the interests of stockholder and the group,the listed companies usually manipulate the financial reporting for self interest on purpose.This is fraudulent financial reporting.In this paper,there are many measures to the fraudulent financial reporting which the listed companies use,such as the asset reorganization,connected transaction,accounting policies change,recording fake revenue and the fee etc.Through the analysis of these measures,it will help standardize the reporting system for the listed companies,and will provide the true and reliable reference information for the related decision makers.


ECONOMIC development makes resources available for a variety of desirable social goals. However, many of these goals are not automatically related to the economic mechanism of production and income distribution in a private enterprise economy. The social values that sustain economic development are often hostile to a nonmarket redistribution of resources. This dilemma between the welfare potential of economic development and the social values that make development possible has long been a subject of intense interest to sociologists.1 In recent years, economists have been paying increasing attention to the problem.2 Economic development of major proportions has occurred in Japan in the last hundred years. This economic success has produced a "social-problem challenge," to which a "welfare response" has been made.! The present article analyzes an aspect of Japan's "welfare response," i.e. public assistance to persons and families in need. It generally shares our methodological concern over the relationship between the economy and public power4 and in particular builds upon our previous work on Japanese poverty.5 There are broadly two parts in this article, devoted respectively to the prewar and postwar phases of public assistance in Japan. The discussion of the prewar phase emphasizes the sociopolitical forces which acted as an intermediary between the "socialproblem challenge" of economic development and the Japanese Government's "welfare response" to the challenge. Given the traditional reluctance of the government of a capitalist society in regard to social policy in general and the usual financial constraints imposed on the government, how fast and to what extent the government


Gus gene is one of the most popular used reporter genes.β-glucuronidase gene,PR1b secreting gene and thymosin gene segments were reclaimed and constructed into polyphyletic expressing vectors and the thymosin gene could be detected easily.The polyphyletic expressing vectors were detected by endonuclease digestion.Carrot callus was transformed using the polyphyletic vectors by bombardment The transformed callus was detected to be blue by X-Gluc tinction,and to be positive by Southern blotting.The results indicated that the polyphyletic expressing vector was transferred into genome of carrot callous.


CPW lines on a 0.015 0-cm resistivity silicon substrate are simulated using HFSS. The electric field distribution from HFSS is analyzed to demonstrate that silicon substrate loss plays an important role and cannot be ignored. A novel physics-based model is developed to predict the characteristics of the CPWs and compared with measured data. A good agreement is obtained up to 110 GHz and demonstrates that the propagation characteristics of CPWs on lossy substrates can be predicted and investigated by the equivalent circuit proposed.


Introduction: Placenta accreta is due to invasive placental implantation. It is diagnosed
when there is failure of delivery of a retained placenta. This is usually complicated
by massive intrapartum hemorrhage that ends by hysterectomy. Case: We report
a case of conservative management in a case of placenta accreta involving an elliptical
shape incision of the lower segment with removal of placenta with underlying
lower uterine segment in a stable patient desiring future fertility. Conclusion: Conservative management may be valid in carefully selected cases of placenta accreta
diagnosed pre-operatively in tertiary hospitals
with availability of blood-bank and multi-disciplinary approach.


Demand of plastic in Indonesia is increased from year to year even though plastic is the biggest waste that causes environmental damage. This study aims to find a solution so that plastic waste does not continue increasing by including external costs into production costs. External costs are cost of damage as a consequence of pollution. This result of this article is expected to be an evaluation in an effort to overcome people's dependence on plastic bags. In addition, it is considered as an alternative policy to regulate plastic usage. Recently plastic waste has become national and international issue. Therefore government intervention is required, for example, the prohibition of using plastic bags with certain contents or policy of tax for certain plastic products. Keywords : Plastic, , external costs, Tax


Bernard Smith, 1916-2011, was a fixture in art history circles in Australia for seven decades. Engaged and committed, he was still writing complex, insightful narratives about art into his eighth and ninth decades, and inter alia vigorously defending any incursion on or critique of his imperium. His passing marks not only the end of an era for art history in Australia, but he was perhaps the last survivor of those towering, paternal, left of centre figures who so greatly influenced and surveilled, rightly or wrongly, the interpretation of Australian culture and the development of humanities scholarship in post-war Australia.


During the last decades, stealth technology has proven to be one of the most effective approaches as far as the endeavor to hide from radar systems is concerned. Especially for military aircraft, "stealth" or "low observable" technology has become ubiquitous: all new aircraft types are designed taking into account low observable principles and techniques, while existing jet fighters are considered for modification in order to reduce their radar signature. Low radar signature for a target means that it is detected and tracked at a shorter distance from a radar. However, low observable does not mean no observable, i.e., complete disappearance from the radar screens. Furthermore, stealthiness comes at a price. Apart from the development cost, stealth aircraft have higher flyaway cost and important maintenance costs, while they have significant operational limitations due to the specific aircraft shape imposed and materials used, and also due to the limited fuel and weapons, which have to be carried internally. Any pylon, tank, missile or pod carried externally increases the radar signature.


In this study,with cv.Zihua 851 as field plant experiment materials,diffe rent kinds of potato cultivating techniques were compared in order to evaluate the effect of straw mulching as sandwich on the yield increasing of potatoes.Results showed that effects of different kinds of cultivation techniques on the yield and commodity characters of potatoes were different.Compared to the local traditional cultivation techniques,the yield and benefit had the significant difference by the methods of straw coverage without the tillage and straw mulching as sandwich.It indicated that the method of straw coverage without tillage could increase the production and profits,and also save the labor.And the straw mulching as sandwich is a method which is easy to operate,could increase production and profits,and then save the labor.For solving the problems brought by the paddy soil compaction,the method of strawmulching as sandwich should be widely applied and extended.


represent struggle in fictions in order to anticipate and prevent foreign reign. The law and theater secure the nation in the imagination. Luke Wilson analyzes corruption in seventeenth-century England and focuses on Chapman's Tragedy of Chabot and the case against Bacon for bribery. This play explores the connection between corruption in public office and the bond between king and subject founded in generosity and dependence. In the epilogue, Deak Nabers offers ideas about legal theory, for instance how Lear and Gloucester raise the issue of natural law at 4.6.148–56. In summing up, Nabers points out, as the collection does, that the law is the center of the world and of its disappearance, which is a little like theater. They represent the world in a fiction of the world that claims truth. They have integrity and question it. This tension is one of the reasons the collection that Kezar has shaped is worth exploring. JONATHAN HART University of Alberta


Recent trends in water engineering education and work practices and their implications for technology transfer and training are discussed. Over recent years there has been also a significant shift in the development of state-of-the-art software from Universities to Industry. Such software is gaining widespread acceptance from the water engineering profession. A case study of co-operative continuing education between an Industry organisation (WP Software) and Universities is also presented. It is concluded that the co-operative continuing education arrangements already in place between WP Software and a number of Universities provide one model of co-operative development which will provide major benefits to all parties concerned.


Manufacturing firms continuously engage in deploying ICT for marketing to promote sales and find new ways to create and deliver value to customers. This study assessed the profitability performance of the Nigerian paints industry vis-a-vis before and after e-Marketing adoption. The study was carried using 240 questionnaire administered on paints manufacturing and marketing firms with a response rate of 84.5% in year 2014. The statistical analysis employed was Ordinary Least Squares technique and the performance measures considered were market share, sales growth and customer retention. The outcome revealed that before the adoption of e-Marketing, market share has more impact on profitability of the firms, while after the adoption of e-Marketing, the sales growth has more influence on the profitability performance of the firms. The study concluded that the deployment of appropriate ICT infrastructures in the companies would enhance the production and sales growth of the paints industry in Nigeria.


The growth of ultrathin iron films on Ag(100) at 135 K has been studied by means of thermal-energy helium diffraction. Film deposition has been monitored by measuring the oscillations of the specular beam intensity during the growth. Information on the island morphology of the deposited film has been obtained by exploiting the dependence of the scattered intensity on the momentum transfer. The set of data indicates that there are definite differences between the growth mode of the first and subsequent layers. The surface of the first monolayer exhibits a two-dimensional morphology, while the estimate of the interface width $w$ [J. W. Evans, Phys. Rev. B 43, 3897 (1991)] from a kinematic analysis of data provides values of ${w}^{2}$ ranging from 0.28 at 2 ML to 0.37 at 5 ML. The obtained values are consistent with the so-called one-hop transient mobility model with adsorption at the fourfold hollow site and show that from the second layer on the morphology gradually deviates towards island growth. The analysis of rocking curves also provides the step height ${(h}^{\ensuremath{'}})$ of the growing interface. At 2, 3, 4, and 5 ML, ${h}^{\ensuremath{'}}$ assumes values that are slightly larger than the value of bulk bcc iron ${h}_{\mathrm{Fe}}=1.43$ \AA{}. This finding is assigned to the occurrence of intermixing through simple arguments based on the conservation of the atomic volumes. The Ag population at the surface of the film is found to decrease with film thickness consistently with recent ion-scattering measurements.


Although a great deal of attention has been given to residue number system (RNS) arithmetic in the digital-parallel form, little attention has been given to the digit-serial form. The digit serial form results in slower operating speeds, but it also provides many interesting and potentially useful properties due to the nonweighted properties of the RNS code. This paper discusses two particular scenarios where digit-serial RNS arithmetic is useful: (i) in variable word length sum-of-products processing, and (ii) in fault tolerant adaptive digital filtering based on combining digit-serial RNS arithmetic and a block LMS adaptive algorithm.


This paper discusses the current concerns surrounding the psychometric
properties of the Transfer Test used in Northern Ireland to select pupils aged
10-11 years old for a grammar school education. It highlights the lack of
validity and reliability in the current selection system and offers computerised
adaptive testing as the viable alternative for academic selection which
reduces inequities associated with coaching and meets the international
standards of validity and reliability.


Because of existing the truncated diffuse double layer (TDDL) in lossal soil of land that the project performed and due to fixation of potassium in this minerals. an investigation has done into the effect of irrigation on wheat yield with a high specific surface area in a soil and comprising illite Clay, which causes usability of potassium for wheat and loss in potassium absorption and yield, after using fertilizer. Three rate of Urea, Potassium Sulfate and Di-Ammonium Phosphate were a. 0,0,0, b. 200,200 and 350 and c. 300,300 and 525 kg/ha respectively. As subplots, flood, sprinkle and drip irrigations were factored in main plots (fertilizers). Each plots irrigated with 120 mm. irrigation intensity for flood, sprinkle and drop were 252,168,102 mm/hour. Irrigated treatments increased potassium uptake and yield in nil fertilizer. Fertilizers also improved nutrient uptake and yield with dry plan which may mean irrigation substitutes fertilizer application. Flood and Drip irrigation methods still improved yield slightly with fertilizer application which may go less interactions. It is likely that moisture may improve potassium diffusion intensity toward roots and increase in its usability. Increasing humidity by soil reduced mechanical resistance may also cause improved roots development potassium absorption, number of clusters and yield at unit of area. In this study we find that irrigation with 120 cm was so useful in release the potassium from (DDL) and other irrigation depth could be tried later.


The argument presented in this paper is that today's workplaces and universities both require and promote individual and collective responsibility for work and that students need to be adequately prepared for this. UK national culture has been characterised as highly individualist. Therefore, internationalisation of home management students in the UK (and other individualist cultures) may require a rebalancing towards collectivity. Ultimately, however, the goal should be to achieve an appropriate balance between individualism and collectivism to prepare the home student to work in diverse national cultures that reflect these dimensions differently. The paper concludes with a research agenda to develop balanced curricula and pedagogy to prepare home management students for their future internationalised lives.


Ethanol produces a striking array of behavioral effects in humans that are dependent on the dose of ethanol administered, whether ethanol levels are rising or falling, and the rate of change of ethanol levels (1). The euphoric, stimulant, and anxiolytic effects of ethanol contribute to its wide recreational use, whereas its sedative effects contribute to its consumption as a nonprescription hypnotic. Yet, at intoxicating doses, ethanol clouds memory and judgment (2), slows information processing and reaction time (3), impairs coordination (4), and disinhibits impulsive or aggressive behavior (5). Perhaps, then, it is not surprising that some of the most damaging consequences of ethanol abuse reflect the impact of ethanol intoxication on behaviors, such as driving, that place a high demand on these cognitive functions (6). With chronic administration, ethanol produces both adaptation and neurotoxicity in the brain, accounting for tolerance and dependence. The ethanol withdrawal syndrome (7) includes anxiety, insomnia, and symptoms of sympathetic nervous system arousal. With more severe levels of dependence and repeated episodes of withdrawal, abstinence may be associated with substantial sympathetic arousal, agitation, perceptual changes, confusion, and seizures. These symptoms may emerge together in the context of delirium tremens, a potentially life-threatening complication of ethanol dependence that generally develops within the initial week of sobriety. Another syndrome, alcoholic hallucinosis, may develop during any phase of the cycle of intoxication and withdrawal. It is associated with persisting hallucinations that may or may not remit with extended sobriety. Acute and protracted abstinence are important contexts for treatment to ensure the medical safety of recovering


The cDNA sequence of allergenic gene expresses a kind of 22 kD protein in tartary buckwheat (TB), was obtained using RT PCR and 3′ rapid amplification of cDNA ends (3′RACE). The cDNA sequence coding for this allergenic protein, consisted of 768 nucleotides, including 588 nucleotides in the open reading frame (ORF) and 180 nucleotides in the 3′ untranslated region. The ORF encoded a functional protein of 195 amino acids. Comparing this allergy from TB with those of common buckwheat (CB), it showed that this allergy in TB shared 95% and 93% nucleotide sequence homology with allergenic protein and legumin like protein in CB, respectively. The protein sequence of TB allergenic protein shared 93% and 83% homology with those of globulin protein in CB and sword bean protein, respectively. The conserved sequence KEEEKE at position 183 188 was probably considered to be the antigen determinant sequence similar to that of other allergenic proteins found in food and pollen.


Any advance in our knowledge about the growth and development of the American colonial economy must first start with a balance-of-payments study. The trade of the thirteen colonies with other areas— principally Great Britain, Ireland, southern Europe, the Wine Islands, the West Indies, and Africa—certainly must have formed, together with the coastal trade between the colonies, a large share of the total market activity. My conclusions from such a study are that the description given of commodity trade by colonial historians has been accurate but that once services as well as goods are considered the picture changes to one where there are only small positive or negative balances remaining on current account for the various regions. As a result, I would conclude that long-term capital flows from Great Britain to the colonies were either small or nil during this period.


Translation is a process involving the transformation and generation of linguistic meaning between two languages.The basic transformation of meaning occurs at the level of deep structures of the two languages with clauses as the operational unit,while the generation of the surface structure in the target language is determined not only by the grammar and the comparative rhetoric features of the target language,but also by the semantic strctures of the sentences at the surface structure level in the source language.


Abstract Background Remdesivir (RDV), was included for the treatment of mild to moderate COVID-19 since July 2020 in our institution, following the initial results from ACTT-1 interim analysis report. With the adoption of RDV, there seems to be anecdotal evidence of efficacy as evidenced by early fever defervescence, quick recovery when on oxygen with decreased need for ventilation and ICU care. We aimed to study the impact of RDV on clinical outcomes among patients with moderate to severe COVID –19. Methods Nested case control study in the cohort of consecutive patients with moderate to severe COVID – 19. Cases were patients initiated on RDV and age and sex- matched controls who did not receive RDV were included. The primary outcome was in-hospital mortality. Secondary outcomes were, duration of hospital stay, need for ICU, duration of oxygen therapy and need for ventilation. Results A total of 926 consecutive patients with COVID – 19 were included, among which 411 patients were cases and 515 controls. The mean age of the cohort was 57.05±13.5 years, with male preponderance (75.92%). The overall in-hospital mortality was 22.46%(n=208). On comparison between cases and controls there was no statistically significant difference with respect to primary outcome [22.54% vs. 20.78%, (p value: 0.17)]. Progression to non-invasive ventilation (NIV) was higher among the controls [24.09% vs. 40.78% (p value: < 0.001*)]. Progression to invasive ventilation was also higher among the controls [5.35% vs. 9.71% (p value: 0.014*)]. In subgroup analysis among critically ill patients, the use of RDV showed decrease in mortality (OR 0.32 95% CI; 0.13 – 0.75 p value – 0.009*). Conclusion RDV did not decrease the in-hospital mortality among moderate to severe COVID – 19. However, there seems to be a significant reduction in mortality in critically ill patients. Disclosures All Authors: No reported disclosures


Alex Kipman, technical fellow at Microsoft, who led a team through years of research and development to produce the HoloLens, recaps the development journey of the mixed reality headset in this article.


In Lecture 25 and 26, we laid the foundation for our study of the three-dimensional dynamics of rigid bodies by: 1.) developing the framework for the description of changes in angular velocity due to a general motion of a three-dimensional rotating body; and 2.) developing the framework for the effects of the distribution of mass of a three-dimensional rotating body on its motion, defining the principal axes of a body, the inertia tensor, and how to change from one reference coordinate system to another. We now undertake the description of angular momentum, moments and motion of a general three-dimensional rotating body. We approach this very difficult general problem from two points of view. The first is to prescribe the motion in term of given rotations about fixed axes and solve for the force system required to sustain this motion. The second is to study the "free" motions of a body in a simple force field such as gravitational force acting through the center of mass or "free" motion such as occurs in a "zero-g" environment. The typical problems in this second category involve gyroscopes and spinning tops. The second set of problems is by far the more difficult. Before we begin this general approach, we examine a case where kinetic energy can give us considerable insight into the behavior of a rotating body. This example has considerable practical importance and its neglect has been the cause of several system failures.


This paper searches and summarizes related concepts of quality control circle and its application situation in the field of nursing in China, describes the existing problems and solution. This paper offers references for improving the quality management of nursing.

Key words:
Review; Nursing care; Quality control circle; Patient satisfaction


The "Association for Knowledge of Colonial African History" (ACHAC) is the source of a constant flow of publications on the colonial past. Its co-founder and director, Pascal Blanchard, is an original figure in the field of colonial studies, who does not hesitate to mix academic endeavors with business strategies. "Colonial culture" and colonial continuum are the two principles used by ACHAC to delineate and legitimize the role of the colonial past in the making of the national memory. By so doing, the association is maintaining a culturalizing approach on the issue of immigration while establishing itself as a privileged institutional interlocutor on historical issues related to discrimination. This essay recounts the entrepreneurial strategy developed by Pascal Blanchard and ACHAC to address to the government and public authorities. It shows how ACHAC's multipositionality makes it possible to blur the boundaries between the marketing sphere and academic codes, thus introducing a new criterion into the social and political uses of the past.


Cai et al. identified the Hippo signaling effector YAP and its transcriptional target, c-Myc, as promoters of cystic kidney pathogenesis. A comprehensive kinase inhibitor screen identified a signaling pathway involving the RhoGEF LARG, the small GTPase RhoA, and the RhoA effector Rho-associated kinase (ROCK) as a critical signaling module between PKD1 and YAP.


Interviews with government affairs representatives in a random sample of 175 Washington lobbying organizations support the popular impression that the volume of pressure group activity has skyrocketed over the past decade. There are many more groups now active on the Washington scene. Moreover, nearly all of them have increased their use of many different kinds of lobbying techniques--not simply, as might be expected, those facilitated by the revolution in electronic technologies or those encouraged by closer representative/constituent relations, but also traditional forms of lobbying. Among the various factors responsible for this explosion in interest group activity are the internal changes in congressional organization since 1974.


Electromyographic investigations masticatory muscles appears one of the important diagnostic methods of modern stomatology. Electromyography like en electroencephalography is the valuable diagnostic method patients with parafunctions masticatory muscles. The perfection of the apparatus for the functional diagnostic in the stomatology gives possibility optimizes the treatment process based on the facts of the objective investigation.


Min-North is a transnational project financed by the Interreg Nord program and coordinated by LTU. The project is a cooperation between Geological survey of Finland, GTK, Oulo University (Finland), ...


Copy of transcript for a letter from Emily Margaret Austin Perry to James F. Perry, in which Emily Perry let's her husband know she has arrived at her current destination, with their daughter, safely but that the trip home will require a detour due to outbreaks of fever around the Bastrop area. Emily Perry also provides a list of tasks that need to be tended to in her absence (preserves, garden, weather boarding, etc.).


It is ambiguous whether one should use this approach only after an endocardial VT ablation failure or when the ECG of clinical VT suggests an epicardial origin. Consequently, multiple published ECG criteria may be used to predict epicardial VT origin. A maximal deflection index (MDI, the longest precordial lead onset-peak time divided by total QRS duration) of 0.55 or more is reported to identify idiopathic epicardial VT with high sensitivity and specificity (4).


It is narrated in the article about scientific and research activity of the Georgian historian and geographer Vakhushti Bagrationi Batonishvili who lived in emigration in Moscow in the Georgian colony, continuing here the scientific activity, since 1724.


Let n 7 and let V be an (n + 2)-dimensional vector space endowed with an anisotropic sesquilinear form. In this article we characterise the graph whose vertices are the two- dimensional subspaces of V and in which two vertices are adjacent if and only if the corresponding two-dimensional spaces are perpendicular with respect to the sesquilinear form.


In most legal contexts, we have finally arrived at a consensus that a competent adult woman's expressed desire not to have sex shall be conclusive on the issue of whether she consented to a sexual contact. The popular form of this idea is the notion that "no means no." Unfortunately, there is no similar consensus that "yes means yes." Instead, there has been much debate about when the expressed consent of a competent adult to sexual contact should be considered legally ineffective. Many contend that expressed consent to sexual relationships between professionals and their patients/clients should be considered legally ineffective, and that such unions should be prohibited.' Colleges and universities are now debating the need for policies that prohibit consensual sexual relationships between professors and students.' Although prohibitions on professional-client sexual relationships are ostensibly gender-neutral, most supporters concede that the intent of the restrictions is to protect women clients from male


Since the initial work of Jewett and Williston in 1971, a remarkable degree of quantification and confirmation of brainstem evoked response data has been published. The consensus of findings has led to the clinical acceptance of BER as an intricate test in the diagnostic assessment of both normal and pathological subjects. BER studies continue to demonstrate that the BER technique does provide an objective means for assessing hearing, especially among infants and difficult-to-test patients. The principle underlying BER is the same as that used for any evoked potential study. Basically, EEG changes resulting from auditory stimuli are recorded by scalp electrodes. The result is a specific wave form which may be recorded and the latency of each wave peak can be accurately measured. All in all, there are seven different wave peaks that are available to use as measurement points, some more stable than others, each reflecting different areas of neural activity in the auditory pathways through the brainstem. The individual peaks reflect changes in the auditory pathway that occur within the first 10 msec after the onset of the auditory stimulus. Each of the seven different waves has its own Roman numeral designator and anatomical location. In brainstem evoked response audiometry, Wave V has been found to be the most diagnostically useful waveform. Accurate estimates of thresholds have been made from the curves described by the latency values of the Wave V's of BER's elicited by click stimuli. These thresholds refer to intensity only and lack the frequency specificity required for audiological assessment. Speculation exists that other stimuli, especially more frequency-specific stimuli, might provide additional frequency-specific information. The purposes of our study were 1) to obtain Wave V latency curves for selected tone pip frequencies; 2) to compare the frequency-specific curves with previously obtained tone pip curves from other studies; and 3) to determine, if possible, the clinical utility of the selected procedure.


Background:Anyang Zhangdeng site is a Pre-Shang site by the unearthed stone artifact mainly and the age is equivalent to the late Erlitou culture,and it is about 200 km away from the Erlitou.Currently the trace element analysis of ancient animal skeletons' samples has rarely been seen.Purpose: This paper attempts to study the Zhangdeng animal's diet and the heavy metal exposure.The paleoenvironmental information is indicated by the former using a new method.Methods: Eight samples(enamel and dentin samples from 4 animals individuals) are tested using the synchrotron radiation X-ray fluorescence(SR-XRF) technique.Results: Fe and Mn contents of ZY9507 were very high and Sr and Zn contents of ZY9505 and ZY9506 were similar,Sr and Zn contents of ZY9508 were higher than the formers and the contents of Cu and As were also obviously higher.Conclusions: Based on the above results: the samples of ZY9507 had undergone diagenetic pollution and wasn't suitable for the paleoenvironmental "fingerprint".ZY9505 and ZY9506 had the similar feeding habits and mainly ate the foods with lower Sr contents such as leaves class.Meanwhile,its lower accumulation of heavy metals shows the lower metal contents in Zhangdeng's paleoenvironment.ZY9508 may be an omnivorous animal and mainly ate the foods with higher Sr such as the grass,while its foods contained relatively high animal protein.Moreover,its levels of Cu and As suggested that it may belong to the "exotic" animal and likely came from the Erlitou site which was the center of bronze casting.Overall,ethnic groups living Zhangdeng had the economic exchanges with the dominators of Erlitou,but the surrounding environment of the former was less affected by Erlitou bronze production activities on the whole.


Universal step-by-step method of design and development of multi-tier H-Darrieus Vertical-Axis Wind Turbine is described. The method is based on the systemic scientific approach of component-wise optimizing of the Turbine including the design of air foils, rotor outline configuration, alternator calculation and the development of power takeoff algorithm.


This article presents a strategy that helps ESL students improve their writing by developing a culturally based self-monitoring strategy that guides them through the revision process. The Cross-Cultural Revision strategy (CCR), which is based on principles of contrastive rhetoric and metacognition, consists of two phases. In the first phase, the students enhance their metacognitive cross-cultural knowledge by comparing various rhetorical patterns. In the second phase the students improve their metacognitive strategies by reading their writing three times. At each reading they revise a different aspect of the text.


The hierarchical routing protocols have been proposed to deal with the path search in wireless multi hop networks in various research works. Most existing designs of ad hoc network routing protocols are based on the assumption of non-adversarial environment, that every node in the network is cooperative and well behaved. However, such assumption usually does not hold in realistic environments. The performance of current routing protocols degrades significantly when misbehaving nodes exist in the network. In this paper we introduce an efficient and effective hierarchical algorithm for MANET, which is called fault-tolerance cluster head based (FTCH) routing protocol. FTCH is proposed to provide a certain packet delivery fraction guarantee and low routing overhead in the presence of faulty nodes. The FTCH routing protocol is evaluated through both analysis and simulations compared with max-min multi-hop routing protocol (MMMH), AODV and DSR. The results show that FTCH greatly improves the ad hoc routing performance in the presence of misbehaving nodes.


Objective:To explore the measures for prevention of bile duct injury in laparoscopic cholecystectomy(LC).Methods:Retrospectively analyze the clinical data of 37 781 cases received LC.Results:Of the 25 cases complicated with biliary duct injury(0.066%),8 were found during the operation,and 17 after the operation.12 cases had transection injury of biliary duct,including 8 cases with mutilation and defect(1 case caused by conversion to laparotomy),and 4 cases due to titanium occlusion with no biliary duct defect.4 cases suffered from partial cutting of common bile duct(CBD);electric injury and seperating injury of common hepatic duct occured in 2 cases respectively;in addition,3 cases had right hepatic duct injury and 2 cases had accessory hepatic duct injury.Among all the cases,5 received bile duct repair(end-to-end anastomosis)and T-tube supporting and drainage;16 underwent chole-enterostomy(Roux-en-Y),1 had abdominal cavity puncture and endoscopic nasobiliary drainage(ENBD),and 3 received bile duct repair and tube drainage.All the cases were cured successfully.Conclusions:Familiar with the anatomy of porta hepatis,careful handling of the Calot~,s triangle,proper conversion to laparotomy,and avoiding of blind confidence could mutually reduce the incidence rate of bile duct injury.


Proteomics is an attempt to describe or explain biological state and qualitative and quantitative changes of protein content of cells and extracellular biological materials under different conditions to further understand biological processes. Protein-Protein interaction prediction and classification is a very important task. Prediction and classification of protein-protein interactions can help in improving the understanding of diseases and can provide the basis for new therapeutic approaches. In this work a model is proposed to classify protein-protein interactions. Jordan Recurrent Neural Network is used to classify the proteinprotein interactions. The model developed gives 97.25% of accuracy which is 8.7% more than Back-Propagation Neural Network.


The 14-3-3 (YWHA or Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation protein) is an acidic and homologous protein family involved in regulation of key biological events including cell cycle, signal transduction and development. They are highly conserved and are expressed ubiquitously across a wide variety of species ranging from plants to animals. Seven isoforms of 14-3-3 exist in mammals, which are encoded by separate genes, have tissue-specific, developmental stage-specific as well as isoform-specific presence and consequences. It is known that these proteins play significant roles in mitosis of mammalian cells and meiosis of amphibians. However, their effects on development and functioning of mammalian gonads and germ cells are not entirely delineated. This paper, for the first time, provides a comprehensive review of the comparative expression, localization/distribution, binding interactions, and importance of the 14-3-3 proteins in gametogenesis and reproduction among multiple female and male mammalian species. Thorough understanding of these proteins in oogenesis and spermatogenesis would help elucidate the physiological basis of fertility in mammals, including humans.


The article summarized natural geological conditions,background conditions of geological and eco-environmental changes around county seat of Zhouqu,and discussed the type of geological disasters,distributions,scale,steady state and characteristics of disaster,and by the example of the landslide in Xieliupo and debris flow in Sanyanyu Valley to detailed analysis the factors affecting,development characteristics and hazard assessment of geological disasters,expected to help the construction of geological disaster prevention engineering.


The school counselor's role is increasingly challenging with various demands of students' problems and the issue of Coronavirus disease (COVID-19) pandemic also affect students' psychosocial and mental well-being. Therefore, school counselors need to equip themselves with high psychological well-being as a self-care factor to deal with burnout, instability, and work stress. This study aims to develop Psychological Well-Being Model among school counsellors. A total of 330 secondary school counsellors from four districts in Selangor were selected as the respondents using the group random sampling method. Data were collected through translated questionnaire instruments, namely Self Compassion Scale, Counselling Self Estimate Inventory, The Assessing Emotions Scale, Spiritual Involvement and Beliefs Scale Revised, and Psychological Well Being-Ryff. Confirmation Factor Analysis (CFA) and Structural Equation Modeling (SEM) show that there is a significant positive relationship between self-compassion, counselling self-efficacy, emotional intelligence, spiritual intelligence, and the school counsellor's psychological well-being. The findings also showed that self-compassion, counselling self-efficacy, emotional and spiritual intelligence affected 76.5% (R2 = 0.765) of variance in psychological well-being. This study is one of the earliest in presenting the school counsellor's psychological well-being model who can contribute to Malaysian education. The implications of this study suggest that the elements of self-compassion, counselling self-efficacy, emotional and spiritual intelligence, and psychological well-being should be applied in the curriculum at the counsellor training level in university so that counsellors have adequate preparation in providing effective services in schools. The Ministry of Education Malaysia, on the other hand, needs to cultivate psychological well-being interventions regularly so that counsellors can always manage various students' issues in schools as well as maintaining psychological well-being in terms of personnel and professionals.


Summary
This paper summarises the journey so far towards the 'single market'. Consumers may expect to benefit from increased choice and cheaper prices but the possibility that quality, as judged by % of characterising ingredient, will be lowered, is a cause for concern. The consumer will have to rely increasingly on labels, assuming that the label information is adequate. Quantitative ingredient information is desirable but provides technical difficulties for manufacturers.

A voluntary 'quality mark' scheme could be a satisfactory replacement for compositional standards but would have to be carefully controlled by independent assessors. The abolition of frontier controls creates a dilemma between the desire to have free trade within the community and the need to give a high priority to public health.


Fetal calf serum (FCS) and 1‐oleoyl lysophosphatidic acid (LPA) were previously found to be potent inducers of invasion (transcellular migration) in an in vitro system. A novel LPA, composed of cyclic phosphate and cyclopropane‐containing hexadecanoic acid (PHYLPA), first isolated from myxoamoebae of Physarum polycephalum, and its synthetic derivatives (cLPA) were tested for their ability to inhibit tumor cell invasion and metastasis. Amoung these, Pal‐cLPA, which has a palmitoyl moiety, was most potent in inhibiting invasion, with 93.8% inhibition at the concentration of 25 μM. Invasion in vitro by mouse melanoma cells (B16), human pancreatic adenocarcinoma cells (PSN‐1), human lung cancer cells (OC‐10) and human fibrosarcoma cells (HT‐1080) was also inhibited by Pal‐cLPA. The stimulation of MM1 cells with LPA triggered F‐actin formation, which was impaired by the addition of Pal‐cLPA at invasion‐inhibitory concentration. Pal‐cLPA induced a rapid increase in adenosine 3′,5′‐cyclic monophosphate (cAMP) concentration in MM1 cells. The addition of dibutyryl cAMP significantly abrogated LPA‐induced invasion by MM1 cells and actin polymerization in the cells. The inhibition of MM1 cell invasion by Pal‐cLPA may be ascribed to an increased level of cAMP. Pal‐cLPA also suppressed invasion in vitro by MM1 cells induced by FCS dose dependently, without affecting proliferation. It also suppressed the pulmonary metastasis of B16 mouse melanoma cells injected into the tail vein of C57BL/6 mice. Thus, Pal‐cLPA is effective in inhibiting invasion and metastasis of a variety of tumor cells. Int. J. Cancer 81:918–922, 1999. © 1999 Wiley‐Liss, Inc.


A novel deep well cement slurry named DHL styrene butadiene latex high temperature channeling cement slurry has been developed to adapt the formation characteristics of Daqing oilfield such as deep buried reservoir, high bottom hole temperature and multitudinous target beds. Different formulations of the slurry in different temperature have been given based on laboratory testing and its normal properties, rheology, bonding strength and channeling controlling ability have been also evaluated. The results showed that the slurry has properties of resisting high temperature, low filtrate loss, right angle cementing, good channeling controlling and better rheology. Application in Daqing oilfield deep wells displayed that DHL cement slurry remained good rheology and compressive strength without foaming in high temperature of 220 ℃ and turbulent flow replacing of the slurry in low return velocity has been achieved, i.e., replacing efficiency was increased. API water loss of the cement slurry is less than 50 mL and the bonding strength curve emerge right angle with short transition period and zero free water. As oil/gas/water channeling was prevented, the engineering requirements of cementing in deep well have been satisfied in the oilfield.