Our goal was to examine ground reaction forces (GRF) following a series of unanticipated jump landing and cutting tasks (JLC) and the differences in these GRF's associated with leg dominance. Nine recreationally active (at least 3x/week of running, cycling, aerobics, or recreational sports participation) right leg dominant females with no history of lower extremity injuries participated in the current study. Each subject conducted a set of 12 (JLC) trails, four (JLC's) to three different directions. The subjects either performed a left cutting (LC), right cutting (RC) at 30 degrees from center or a straight ahead center cutting (CC) maneuver. Landing impact (IP) and push-off (PO) forces for both the dominant and nondominant (IPN, IPD, PON, POD) were compared using ANOVA with repeated measures and post-hoc comparisons with t-tests. Significant differences were found between dominant and non-dominant leg IP and PO peak GRF during LC task. No significant differences were found for all other JLC tasks. These data suggest that the more extensive the change of direction opposite the dominant leg, the greater the forces acting on the dominant leg versus the forces felt during a change of direction towards the nondominant leg of the subject. This would suggest that the amount of forces the non-dominant leg can accommodate is less than the dominant leg, which could play a role in anterior cruciate ligament injury.


Aim: Although allogeneic stem cell transplant (alloSCT) remains the only curative option for myelofibrosis, novel therapeutic agents, the application of new prognostic scoring systems and the emergence of molecular genetic analysis have lead to a new management landscape in myelofibrosis. In view of these recent advances, we aimed to review national practice in transplanting myelofibrosis patients and its outcomes.
 Methods: A retrospective study was conducted using the Australasian Bone Marrow Transplant Registry (ABMTRR) data on patients who underwent alloSCT for myelofibrosis at Australian/New Zealand transplant centres between 2006 and 2017. Participating centres completed an online questionnaire and responses were reviewed centrally by the ABMTRR.
 Results: 142 patients underwent alloSCT for myelofibrosis, primary (n=94) or secondary (n=48) (Table 1). 52% had HLA-identical sibling donors and 45% had matched unrelated donors (UD). Median follow-up was 51.8 months (range: 3.1-148). Cytogenetic abnormalities were identified in 29% of 120 patients who were tested pretransplant. JAK2 mutation testing was performed in 74% of patients whilst other mutations (CALR, MPL, EZH2, IDH, SRSF2, ASXL1) were rarely tested (1.4-8.4%). Only 4.2% of patients had next generation sequencing. Before transplant, 16% had splenectomy or splenic irradiation and 54 patients (38%) received JAK 1/2 inhibitors (JAKi), of whom 92.5% had Ruxolitinib.
 Median time to neutrophil engraftment was 20 (range: 10-43) days whereas median platelet recovery time was 28 (range: 13-230) days. 9 patients (6.3%) had primary graft failure and 11 patients (7.7%) had secondary graft failure. 60% had chimerism studies using cytogenetic or molecular techniques at 3 months post transplant; 63% of those assessed achieved complete (≥95%) donor chimerism. CMV reactivation was detected in 32% and 10% had sinusoidal obstruction syndrome. The cumulative incidence of grade II-IV acute GvHD was 21.4% and grade III-IV acute GvHD was 8.7%. The cumulative incidences of limited and extensive chronic GvHD at 5 years were 11.1% and 18.1% respectively. Overall survival (OS) was 67% at 1 year and 57% at 5 years. GvHD free progression free survival was 54% at 1 year and 42% at 5 years (Figure 1). The cumulative incidence of non-relapse mortality (NRM) was 16% at 100 days and 25% at 1 year.
 In multivariate analysis, use of an UD was a significant independent unfavourable risk factor for OS (HR 2.26, 95%CI 1.17- 4.33, p=0.015) and NRM (HR 3.02, 95%CI 1.36-6.71, p=0.007), while splenic irradiation/splenectomy resulted in shortened neutrophil (HR 1.88, 95%CI 1.00-3.54, p=0.05) and platelet recovery time (HR 2.13, 95%CI 1.12-4.05, p=0.02). Use of UD significantly increased the incidence of grade II-IV acute GvHD in multivariate analysis (HR 5.66, 95%CI 1.99-16.11, p=0.001) whereas use of antithymoglobulin or alemtuzumab significantly reduced it (HR 0.27, 95% CI 0.09-0.79, p=0.017). Neither use of JAKi prior to alloSCT nor presence of JAK2 mutation had a significant impact on OS or NRM.
 9 patients underwent a second alloSCT for myelofibrosis and median length of time from the first transplant was 22 (range: 1-132) months. 4 patients were transplanted for disease relapse and 3 patients for graft failure. For the second transplant cohort, NRM at day 100 and 1 year were 11.1% (95% CI, 0.4%-40.6%) and 33.3% (95% CI, 6.6%-64%) respectively, while 1-year and 5-year OS were 66.6% (95% CI, 42%-100%) and 44.4% (95% CI, 21.4%-92.2%).
 Conclusion:
 Survival rates in alloSCT for myelofibrosis in this Australasian cohort were comparable to international studies.
 There is a rise in the numbers of patients treated with JAKi pretransplant (Figure 2). Although this does not appear to have any effect on transplant outcomes, reduced symptom burden associated with increasing use of pre-transplant JAKi may increase the numbers of patients considered eligible for alloSCT.
 Although splenectomy/splenic irradiation had a positive impact on engraftment, it did not improve the survival outcomes.
 Our results show a negative influence of UD on OS and NRM, possibly related to an increased incidence of acute GVHD in the UD group.
 In light of the rise in utilization of alloSCT in the management of myelofibrosis, there is a need for further prospective studies incorporating molecular testing and the new comprehensive clinical-molecular myelofibrosis transplant scoring system.

 Spencer: Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Servier: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Haemalogix: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Secura Bio: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Sanofi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen Oncology: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Specialised Therapeutics Australia: Consultancy, Honoraria. Purtill:MSD: Honoraria; Novartis: Honoraria, Other: Travel for speaking and advisory boards; Gilead: Honoraria, Other: Travel for speaking and advisory boards; Janssen: Honoraria. Browett:Roche: Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees; AbbVie: Membership on an entity's Board of Directors or advisory committees; Merck: Membership on an entity's Board of Directors or advisory committees; Achillion: Research Funding; Beigene: Research Funding. Szer:Sanofi: Honoraria, Other: Travel, Research Funding; Takeda: Honoraria, Other: Travel, Research Funding; Pfizer: Honoraria, Other: Travel, Research Funding; Alexion: Honoraria, Other: Travel, Research Funding; Amgen: Honoraria, Other: Travel, Research Funding; Celgene: Honoraria, Other: Travel, Research Funding; MSD: Honoraria, Other: Travel, Research Funding; Novartis: Honoraria, Other: Travel, Research Funding; Prevail Therapeutics: Honoraria, Other: Travel, Research Funding. Ritchie:Amgen: Consultancy, Honoraria, Research Funding; Pfizer: Consultancy; BMS: Research Funding; Takeda: Research Funding; Beigene: Research Funding; Imago: Research Funding; Novartis: Honoraria; Sanofi: Honoraria. Greenwood:Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees. Gottlieb:Merck: Consultancy; AbbVie: Consultancy; Gilead: Consultancy; Novartis: Consultancy; University of Sydney: Employment; Haemalogix P/L: Membership on an entity's Board of Directors or advisory committees, Research Funding.


An equivalent circuit and computer solution were formulated for describing the output of a metal-sheathed bifilar thermocouple degraded by insulator shunting at high temperatures. This steady-state equivalent circuit model can be used for prediction of errors in thermocouple calibrations, for examining the effects of changes in thermocouple configuration or materials properties, and for examining methods for interrogation or surveillance of the shunting thermocouples.


A number of studies have noted that the use of distinct reference periods when comparing indices measuring the frequency of days exceeding a particular temperature percentile threshold leads to apparently different behaviour. We show that these differences arise because of the interplay between the increasing temperatures and the choice of reference period. The time series of the indicators calculated using the different reference periods are offset, as expected, but also diverge. Linear trends calculated over the same period from the same underlying data but where different reference periods have been used are substantially different if a change in climatological conditions has occurred between the two reference periods. We show this not only occurs in our simple empirical approach, but also for the averages of gridded observational and reanalysis datasets and also at a station level. This has implications for data set comparisons using trends in temperature percentile indices that are based on different reference periods. It also has implications for updates to standard reference periods used to monitor the climate.


ABSTRACT The purpose of this study was to investigate whether intravenous crotalphine produces significant sedation, as well as physiological changes, in healthy standing horses. Six mares, aged 8 years and weighing 415kg underwent three different treatments in a crossover design: TA (acepromazine: 50μg.kg-1), TC (crotalphine: 0.01μg.kg-1) and TX (xylazine: 1000μg.kg-1), intravenously. At various time points over 60 minutes, physiologic variables were recorded: heart rate, respiratory rate, and rectal temperature. The head height from the ground (HHG) was evaluated in centimeters. Data were analyzed using ANOVA followed by Dunnett's test or Friedman followed by Dunn's test, under 5% significance. Heart rate decreased significantly at M5 and M10 compared with Mb in TX (28±7, 26±6 and 40±8 beats/minute-1, respectively; p=0.0004). Respiratory rate and rectal temperature did not differ among groups or time points. The HHG significantly decreased in all groups compared with Mb at various time points (p<0.0001). In conclusion, crotalphine did not produce reliable and durable sedation in healthy standing mares and did not influence cardiorespiratory variables in a clinically relevant manner.


The fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), a notorious pest of maize was recorded from India as an invasive insect pest severely damaging maize crop during 2018 from Karnataka state, South India et al ., 2018 management the new regions of the globe lead IITA ( observe, expansion FAW countries India as Bangladesh, Nepal, Pakistan, beyond the the whole Asian continent seriously risk with dire


The aim: to perform research of the species composition and condition of urban and suburban ecosystems of the Khopyor River Region. The route method was used for the species composition of woody plants. Also, using this method the conditions of the growth of trees and shrubs were described. The data of field ecological observations and researches were analyzed in the laboratory conditions. Plant species were identified by means of determinants. The geographical analysis and floristic belonging of plants in towns and villages is carried out. A diagnostics of the vital state of woody plants is carried out according to the complex of their external signs on ecologically different territories. It is found that the greatest species diversity is characterized by the family Rosaceae Juss. The poverty of the species composition of woody plants in the towns and villages of the research area is associated with insufficient introduction. The largest number of species of trees and shrubs in urban areas are characterized by parks and squares. Of great concern is the weakening of the vital condition of woody plants in the area of suburban highways. The greatest values of damages of the objects of the research are revealed at wood plants as part of roadside territories of towns and villages. The expediency to restore greening in ecologically problematic urban areas is obvious.


Growth performance as well as marbling is the main breeding objectives in Japanese Black cattle, the major beef breed in Japan. A previous study has identified the c.1326T>G single nucleotide polymorphism (SNP) in the NCAPG (non-SMC condensin I complex, subunit G) gene that leads to the amino acid change p.Ile442Met in the NCAPG protein, which is a candidate causative variation for a bovine carcass weight (CWT) quantitative trait locus (QTL). In this study, we first confirmed the association of the c.1326T>G SNP with the growth-related traits, CWT, rib eye area (REA) and rib thickness (RT), and showed significant effect of the SNP genotypes on the marbling trait, beef marbling score (BMS), in the Japanese Black beef cattle population of the Niigata prefecture, with the G allele being associated with a favorable phenotype of these traits. Thus, we concluded that the c.1326T>G SNP is useful for effective marker-assisted selection to increase meat quality and meat productivity in Japanese Black beef cattle of the Niigata prefecture. Furthermore the frequency of the favorable G allele of the c.1326T>G SNP in the Niigata prefecture population was significantly lower than the frequency of this allele in Japanese Black cattle population of the Kagoshima prefecture. However, no statistically significant difference was detected between the allele frequencies estimated by maternal alleles in the half-sib progeny steers in the Niigata prefecture population and obtained in Japanese Black cattle population of the Kagoshima prefecture.


Pancreatic cancer is an aggressive disease which has become the third leading cause for cancer deaths in the United States. Tyrosylprotein sulfotransferase 2 (TPST2) is a post‐translational modification enzyme which locates in the trans‐Golgi apparatus and catalyzes the sulfation of proteins' tyrosine residues. Moreover, tyrosine sulfation has been shown to play a critical role in protein‐protein interaction. By analyzing TCGA data, we found that the expression of several known substrates of TPST2 were affected in pancreatic cancer. However, whether TPST2 affects cancer cell behavior is unclear. To determine the role of TPST2 in pancreatic cancer, MTT cell growth assay and soft agar colony formation assay were performed to assess cancer cell proliferation in MiaPACA2 and PANC‐1 human pancreatic cancer cell lines. Migration and invasion of cancer cells in vitro were evaluated by transwell assay. CRISPR‐Cas9 was utilized to establish TPST2 KO stable cell lines. Total RNA‐seq analysis was performed to analyze the transcriptome in the TPST2 KO and control cells. We showed that knockdown of TPST2 inhibited the proliferation of pancreatic cancer cells both in vitro and in vivo. Knockdown of TPST2 also decreased migration and invasion of pancreatic cancer cells in vitro. RNA‐seq analysis revealed that the extracellular matrix (ECM) receptor interaction pathway was significantly downregulated in TPST2 KO cells. We further demonstrated that expression of intergrin beta 4 (ITGB4), a protein involved in ECM receptor interaction pathway, was decreased when TPST2 was knocked‐down or inhibited. Our studies have uncovered the role of protein sulfation in pancreatic cancer and may establish TPST2 as a therapeutic target for pancreatic cancer.


Once in a great while, the programmer has need for floating point arithmetic in greater precision than the hardware provides. This capability is usually not performance critical, since most performance critical code deals with measured quantities in the physical world, where it is hard to imagine a measurement precision that exceeds the sixteen or so decimal digits provided by standard IEEE-754 double precision arithmetic. Instead, the high-precision arithmetic is used to guard against catastrophic loss of significance, where a difference is computed between floating point numbers of nearly the same magnitude, or against accumulation of roundoff errors. In the course of developing numeric software, the analyst will usually rectify these problems as a matter of course, but the need arises to verify that nothing has been missed, and to compute intermediate constants (such as coefficients of power series) so that they are guaranteed accurate.


The interaction of the pump wave, the scattered wave and the space-charge wave in a free-electron laser with an electromagnetic wave wiggler and an axial guide field is analysed, where both the scattered wave and pump wave are circularly polarised. The linear dispersion and non-linear growth of these three waves are derived in the laboratory frame. The possibility of explosive instabilities for a fast electromagnetic wave pump propagating counter to the electron beam is discussed and its critical condition is ( omega p+kp nu z0)- omega b/ gamma zo< omega c<(kp nu z0), where omega p and kp are the pump wave frequency and wave number, omega b, nu zO and gamma z0 are the plasma frequency, initial axial velocity and Lorentz factor of the relativistic electron beam, respectively, and omega c is the electron cyclotron frequency in the axial guide field. Group II orbits ( omega c> omega p+kp nu z0) may no longer give positive gain in the process of three-wave interaction.


Advertising can be seen as having an impact both logical and emotional on the creation of social attitudes and consumer behavior. As a result, advertising produces psychological implications and clashes with the social ethical and moral values on which they are supposed to be based. In every day advertisements such as tv and internet commercials and banners, the stereotypical portrayal of females in advertising, which typically involves depictions of a house lady, a businesswoman without a family or only a decoration, can be seen. However, the paradox faced by women, with no direct connection to the product or service marketed, poses the following questions for this paper: whether it is appropriate or desirable to represent women frequently in ads, If this was the most popular "means" for sale of the women beauty model indicated. The best approach to counter two competing factors is to have a negative effect on women's happiness and self-confidence, contrasted with morals and ethics and the marketing phenomenon, which seeks to attract people and therefore alter the way they shop.


In the Great Hanshin Earthquake which occurred in January 1995, extremely serious damages to the elevated expressways were found. Some of those piers are made of steel and many of them buckled and revealed plastic deformations. One of them revealed the circumferentially uniform outward bulge at the middle portion in the axial direction, though the buckling of a long circular cylinder will occur at it`s bottom end accompanied by more complicated deformation patterns typical to the bending buckling. In this study, simple reduced scale models of the pier were fabricated and the dynamic and static buckling tests were performed. The effect of the girder weight or vertical excitation on the buckling phenomena were investigated. In addition to the tests, static buckling analysis using FEM was also performed in order to clarify the causes for this specified buckling phenomena.


Oxide‐based photoelectrodes commonly generate deep trap states associated with various intrinsic defects such as vacancies, antisites, and dislocations, limiting their photoelectrochemical properties. Herein, it is reported that rhombohedral GaFeO3 (GFO) thin‐film photoanodes exhibit defect‐inactive features, which manifest themselves by negligible trap‐states‐associated charge recombination losses during photoelectrochemical water splitting. Unlike conventional defect‐tolerant semiconductors, the origin of the defect‐inactivity in GFO is the strongly preferred antisite formation, suppressing the generation of other defects that act as deep traps. In addition, defect‐inactive GFO films possess really appropriate oxygen vacancy concentration for the oxygen evolution reaction (OER). As a result, the as‐prepared GFO films achieve the surface charge transfer efficiency (ηsurface) of 95.1% for photoelectrochemical water splitting at 1.23 V versus RHE without any further modification, which is the highest ηsurface reported of any pristine inorganic photoanodes. The onset potential toward the OER remarkably coincides with the flat band potential of 0.43 V versus RHE. This work not only demonstrates a new benchmark for the surface charge transfer yields of pristine metal oxides for solar water splitting but also enriches the arguments for defect tolerance and highlights the importance of rational tuning of oxygen vacancies.


One hundred of agricultures soil samples have been collected from different locations in Hillah city. Twenty one Streptomyces isolates were obtained from these samples. These isolates have been cultured and purified on international Streptomyces project type-2 (ISP-2). Antibacterial agents were extracted from these fermentations cultures and tested against gram positive bacterial species (Staphylococcus albus, Staphylococcus aureus and Streptococcus pyogenes) and gram negative species (Klepsilla Pneumonia, Escherichia coli, Pseudomonas aeruginosa, Serratiamarcescens and Aeromonashydrophila) on Muller Hinton Agar. tenStretopmycesspp from these isolates were found have antibacterial activity, these isolates were named as symbols such as S.K-5, S.M.A -17, S.N-22, S.M-34, S.S-46, S.H-52, S.H.A-65, S.K-72, S.K.A-83 and S.A-98. These isolates were identified by molecular method by used PCR for identified the 16S rDNA gene as well as the morphological methods, which included light microscope for study the aerial and substrate mycelia and electron microscope for study of spores surface morphology and the results revealed all these isolates were belonged toStreptomtces spp. In addition to used PCR for identification ofstrA streptomycin phosphortransferase gene which responsible for streptomycin production. Keywards: Actinomycetes , Electron microscope, Genes


The 《Hyohaengnok(孝行錄, Record of Filial Piety)》 was completed by Kwon Bo's adding 38 pieces of Chinese Folklore of Filial Piety besides the Painting of the Twenty-Four Filial Exemplars to the original version dedicated to himself, who is Kwon Jun's father. The original version was composed of the Painting of the Twenty-Four Filial Exemplars, which Kwon Jun had ordered up, and the comments added by Yi Chehyon. However, there exists distinction in the characters between the stories selected in the Painting of the Twenty-Four Filial Exemplars for Record of Filial Piety and the contemporary Twenty-Four Filial Exemplars circulated in China. Archeologists excavated a large number of Painting of the Twenty-four Filial Sons(二十四孝圖) in Song(宋), Jin(金), Yuan(元) tombs throughout Henan and Shandong Provinces. All of these Painting of the Twenty-four Filial Sons are identical to the Twenty-Four Filial Exemplars of the Record of Filial Piety Given this, how can we explain the change in characters that had been consistent up to Yuan(元) Dynasty? Presumably it is due to the substitution of parts involving brutality or immorality such as cutting off of limbs or abandonment of a parent that occurred after Yuan(元) period. Therefore, the Twenty-Four Filial Exemplars in the current Record of Filial Piety are the original Twenty-Four Filial Exemplars that had been popular in the northern parts of China in Song(宋), Jin(金) and Yuan(元) periods. However, in Korea the Twenty-Four Filial Exemplars developed into a moral and instructive text of Three Fundamental Principles and the Five Moral Disciplines in Human Relations with the addition of moral texts by Gwon Geun(權近). By contrast those transmitted to Japan, China and Vietnam became a major source of recreational literature with moral lesson. In this regard the Twenty-Four Filial Exemplars can be seen as a valuable material for studying the commonness and difference within the East Asian culture as well as the cultural exchanges.


This paper discusses paeallelism and concurrency in the light of current computing practices. A special case of SIMD machines, also known as systolic arrays, is analyzed. A new architectural engine, the GAPP systolic array, is studied in the application domains of signal and image processing. Also included are database and associative processing csses. Some interesting conclusions can be drawn from a PE which can also be viewed as an intelligent memory.


In current study, PGPRs (Plant Growth-Promoting Rhizobacteria) were isolated from the rhizospheric soil of Cannabis sativa and assessed for their potential of auxin biosynthesis and enhancement of growth of Vigna mungo. Strains identified on account of morphological characteristics and Gram's staining were confirmed by 16S rRNA gene analysis for final taxonomic status. Nine bacterial strains showed similarity with genus Bacillus while B16 and B17 showed similarity with Serratia marcescens and Stenotrophomonas maltophilia, respectively. Colorimetric analysis of bacterial culture supernatants revealed the auxin synthesis and production ability of the isolated strains at 0 and 500 µg ml-1 concentrations of L-tryptophan. At 500 µg ml-1 L-tryptophan concentration, B. subtilis (B15), S. maltophilia (B17) and B. subtilis (B11) produced significant levels of 217.1, 197.3 and 116.4 µg ml-1 auxin, respectively (P<0.05). In vitro rooting assay manifested a significant increase of 60% and 84% in root length with B. subtilis (B15) and B. subtilis (B11) over control, respectively (P<0.05). For pot trials seeds of Vigna mungo treated with bacterial strains single cultures were evaluated for their ability to enhance plant growth. For shoot length, P. aryabhattai (B9) and B. licheniformis (B3) recorded 75% and 74% increases, respectively, over control (P<0.05). For fresh weight, B. subtilis (B5) and P. aryabhattai (B9) showed 33% significant improvements, over control (P<0.05). While B. subtilis (B5) exhibited 31% increase in dry weight, in comparison with control (P<0.05). The results demonstrate that bacterial strains isolated from C. sativa can synthesize auxin and thus promote the growth of V. mungo.


Objective To evaluate the effect of Mosapride combined with gastrointestinal pacemaker in the treatment of diabetic gastroparesis(DGP).Methods Sixty cases of DGP were randomly divided into 2 groups,the treatment group with Mosapride combined with gastrointestinal pacemaker and the control group only with Mosapride.The treatment course was 2 weeks.The gastrointestinal symptoms scores were recorded before and after treatment.Results The gastrointestinal symptoms scores declined evidently in the treament group compared with the control group.The total effective rates were 90.0% in the treament group and 63.3% in the control group.The difference between the two groups was statistically significant(P0.05).Conclusion It is assumed that Mosapride combined with gastrointestinal pacemaker could ameliorate efficiently the symptoms of DGP.


This report begins by providing background on agency purchase card programs. It then discusses identified weaknesses in agency purchase card controls that have contributed to card misuse, and examines legislation introduced in the 110th Congress that would address these weaknesses.


Reproduction of pink bollworm, Pectinophora gossypiella (Saunders), male and female moths from 10- or 15-krad irradiated pupae mated to untreated females or untreated males was reduced 88% or more. Numbers of spermatophores per female from male moths emerging from irradiated pupae were significantly reduced. Percentages of males mating was not different from that of untreated insects except for females from 15- krad pupae paired with untreated males. Inherited sterility was exhibited in both male and female progeny of irradiated parents but was much more apparent in progeny from irradiated male parents. Generally, moths from irradiated pupae and their progeny had reduced longevities. Overall averages across all mating combinations indicated that age of pupae at the time of irradiation treatment and treatment by sex significantly affected oviposition, egg hatch, mating, and longevity. Results varied in some instances and significant interactions of age and mating combinations occurred.


We present results from a vibrating mesh nebulizer for which the mesh is a micro-machined silicon membrane perforated with up to a thousand micron-sized, pyramidal holes. Finite element modelling is used to better understand the measured results of the nebulizer when tested in the dry state as well as when loaded with a liquid. In particular, we found that the frequency response of the system is well represented by the superposition of the frequency response of its two main subcomponents: the piezo driving unit and the silicon membrane. As such, the system is found to have resonance peaks for which the complete assembly flexes in addition to peaks that correspond to the flexural resonance modes of the silicon membrane on its own. Similarly, finite element modelling was used to understand differences observed between the frequency response measured on the nebulizer in the dry condition compared to its wet or liquid loaded operation. It was found that coupling between the structural and the acoustic domains shifts the resonance peaks significantly to the left of the frequency plot. In fact, it was found that at the operating frequency of the nebulizer, the system resonates in a (0,3) when the membrane is loaded with a liquid compared with a (0,2) resonance mode when it is operating in the dry state.


Mastocytosis is a hematopoietic disorder characterized by abnormal growth and accumulation of neoplastic mast cells (MC) in various organ systems. Using updated WHO criteria and the proposal of the consensus group, the disease can be divided into cutaneous mastocytosis (CM), indolent systemic mastocytosis (ISM), smouldering SM (SSM), SM with an associated hematologic neoplasm (SM-AHN), aggressive SM (ASM), and mast cell leukemia (MCL). In adult patients with skin involvement but unknown/unavailable bone marrow (BM) studies, the provisional diagnosis ´mastocytosis in the skin (MIS)´ is appropriate. Although this classification has been validated repeatedly and is of prognostic significance, additional prognostic parameters have been identified in recent years (yrs). We have established a patient-registry in the ECNM where over 1,000 cases with confirmed mastocytosis are included. The aim of this study was to identify and validate new prognostic variables predicting survival in patients with mastocytosis and to prepare a simple prognostic scoring system applicable in daily practice. Using the data set of the ECNM registry we analyzed overall survival (OS) and event-free survival (EFS; i.e. until death or progression) in 1,088 patients with mastocytosis (median age: 45.7 yrs; range: 0.1-83.3 yrs, f:m ratio, 1:0.79), including CM (n=152), MIS (n=126), ISM (n=650), SSM (n=26), SM-AHN (n=89), ASM (n=35), and MCL (n=10). The median observation period was 3.5 yrs (75-25% percentile: 1.5-6.9 yrs, maximum 34.1 yrs). In the entire cohort, the median OS was not reached. The probability to be alive after 5, 10, and 20 yrs was 89%, 83%, and 70%, respectively. As expected, the WHO classification turned out to be of utmost predictive significance (Figure 1A; p 70 yrs, PLT 70 yrs, PLT Disclosures Sperr:Amgen: Honoraria, Research Funding; Novartis: Honoraria. Gotlib:Incyte Corporation: Honoraria, Membership on an entity9s Board of Directors or advisory committees, Research Funding. Valent:Amgen: Honoraria; Celgene: Honoraria, Research Funding; Novartis: Honoraria, Research Funding; Deciphera Pharmaceuticals: Research Funding; Ariad: Honoraria, Research Funding.


Poly(L-lactide) (PLLA) was mixed homogeneously with diphenyl ether (DE) at high temperature in a range of PLLA/DE compositions from 100/0 to 100/75 in wt.-%. Cooling of the mixtures yielded white solid products without migration of the liquid DE. Their melting temperature was lowered from 173 to 123°C as the DE content increased. At an optimum PLLA/DE composition of 100/60, a unique crystallosolvate consisting of large spherulite of PLLA, as detected using polarized optical microscopy, was exclusively generated in powder form. Wide and small angle X-ray scattering revealed that the PLLA chains form a lamellar structure with a highly ordered crystalline state (α-form) and that the lamellar spacing is extraordinarily thick, reaching 34 nm. It was therefore suggested that DE partitions into the amorphous layers sandwiched between the crystalline layers and that the specific solvation interaction between DE and PLLA may stabilize the crystallosolvates.


Nutrition and vitamin A deficiency has been considered as a wide-spread public health problem among young children of socio economically backward families in many parts of the world often leading to increased incidence of xerophtinalmia and malnutrition. In India situation with respect to nutrition and vitamin A deficiency varies from region to region due to difference in dietary habits and socio economical status. Several studies related to food and nutrient intake of population of poor socio economical status have been carried out in rural areas. During past few decades rapid industrialization and urbanization has taken place in India and not much information is available on the food and nutrient intake of urban families of poor socio economical status. Diets of low income population are cereal based and most of the nutrients is met by cereals.


Abstract— This paper is a preliminary report on the formation of ZnS thin films thicker than five monolayers using electrochemical atomic layer epitaxy (ECALE). Thin films were electrodeposited on Au‐coated Si wafers and ITO‐coated borosilicate glass slides. The deposits' morphology was examined by scanning electron microscopy and composition was determined by electron probe microanalysis. Grazing‐angle x‐ray diffraction showed cubic (111) ZnS films.


This paper will investigate a problem related to Fermat's Last Theorem (FLT). Now that FLT has been proven, we know that the Diophantine equation an + bn = cn + D cannot have a D value of 0 when n < 2. The question still remains of exactly how small |D| can get. By use of a computer program we have found that there are a large number of solutions to this problem that have |D| value of one. Some of these solutions inspired the creation of identities that can generate many more such solutions.
Faculty Mentor: Ian Blokland, Associate Professor of Physics and Mathematics


With all the excitement over the potential of nanotechnology, has any research addressed the potential toxicity nanoparticles may have on our health and environment?


Members of RSD will shortly be asked to decide an important issue, the pro posed merger of the division with ASD, the Adult Services Division. Such a com bination has been the subject of "talks" for some years. As it seems probable, however, that members of RSD will find the topic a new one, this paper is pro vided as an attempt to clarify the history of the proposal and to comment on some of the issues involved. In 1966, in response to a sentiment felt increasingly in some quarters that the two divisions overlapped to some extent, the two presidents appointed a Commit tee on Common Concerns with membership drawn from both divisions in equal proportions. The original charge given the committee did not specify merger as a goal, but rather the identification of common concerns and recommendations for closer cooperation in such instances. Accordingly, the committee identified a num ber of related activities, especially at the committee level, and recommended to both boards that certain committees contain joint representation. For several years, therefore, ASD representatives have sat as members of certain RSD committees. More recently the Committee on Common Concerns has become convinced that a closer tie should be sought, and at Midwinter of 1971 its recommendation for merger was presented to, and approved in substance by both divisional boards, subject to the approval of the respective memberships. Today, in view of the uncertainty about the future of ALA?our only certainty is that of some impending change in the parent organization?an internal arrange ment such as the proposed merger cannot be considered in a vacuum, or as the business only of members of the two divisions, as it might have in a more stable period. I shall, therefore, after listing the reasoning behind the proposal?the "common concerns"?point out the existing variations between the divisions and then comment on the merger in the light of proposals for the reorganization of the association as a whole brought forth by ACONDA, and others. In these sum maries of the issues, I shall bear in mind the special questions and concerns of RQ readers and the RSD membership in order to assist members in understand ing and intelligently weighing the issues. While I write as a member of both divi sions, I write also as a former president of RSD whose interests are important to me; insofar as I am able to subordinate my own views, I write not as an advocate but as an interpreter.


Many traditional investigations of saturation in multiphoton absorbers with the z-scan method use an approximate analytical formula that assumes a steady-state approximation. Using a numerical simulation for Maxwell's equations for laser propagation including diffraction and coupled electron population dynamics, we show that the commonly used analytical formula for determining saturation in multiphoton absorbers is often incorrect, even when the sample thickness is only one diffraction length. Using published experimental data on an organic chromophore, we show that saturation, in fact, does not occur at the laser intensity values predicted for these two and three photon absorbers. We numerically fit the published experimental z-scan data and obtain new absorption coefficients for multiphoton absorbers that accurately reflect their intrinsic values. The new values are from three to ten times larger than the published values. Because multiphoton absorbers are being used more extensively in many applications such as optical limiter, medical diagnostics and two photon microscopy, it is important to have accurate values for the two and three-photon absorption coefficients. Knowing the real value of the multiphoton absorber coefficients, even for a single diffraction length, is therefore of the utmost importance. In particular, the laser intensity at which the absorber saturates can determine which absorber is useful for a particular application.


Misuse of Narcotics and Psychotropics can be categorized as a crime without victims or (Crime Without Victim) is a crime that does not cause suffering to victims of other people's criminal acts. Actually the use of Narcotics and Psychotropics itself is very necessary for medical purposes. So that the use is unattended and dependent for its users. The Forensic Laboratory as a special police tool has the task of assisting the police of the Republic of Indonesia, assisting in evidence to reveal everything related to all kinds and kinds of Narcotics and Psychotropics, who are the users and who are the dealers. The problems that will be discussed in the thesis are how the duties and functions of the forensic laboratory are in an effort to prove evidence against criminal acts of narcotics and psychotropic abuse and what are the factors that can be an obstacle for the forensic laboratory in an effort to uncover criminal acts of narcotics and psychotropics. The method used in writing is the normative legal research method, namely research conducted by examining library materials or primary legal materials and secondary legal materials. The results of the study show that the Forensic Laboratory was established to assist in finding and collecting evidence in the investigation process as stated in Article 7 paragraph (1) letter of Law Number 8 of 1981 concerning Criminal Procedure Code (KUHAP) which states that bringing in the necessary experts in in relation to the examination of cases and Article 120 paragraph (1) of the Criminal Procedure Code states that if the investigator deems it necessary, he or she may ask for the opinion of an expert or a person with special expertise. The Forensic Laboratory also has the task of examining Narcotics and Psychotropics and in proving it, evidence is needed to be used for investigation purposes. Inhibiting factors can occur in carrying out proof of evidence so that efforts to overcome obstacles to forensic laboratory examinations need to be implemented, so that by implementing efforts to overcome obstacles can facilitate forensic laboratories in carrying out their duties and functions.


The aim of this report has been to perform a risk analysis of ABB Automation Products activity in building 358. The risk analysis consequences are expressed in economical terms and the measurement of the risk is presented as the expected annual cost due to fire. The model used is based on an event tree which describes what happens if a fire breaks out in the building. The effect of different fire prevention measures, such as sprinkler, fire compartments etc. is
modelled by using a combination of expert judgement and statistics. Since the scope of the risk analysis deals with the complete building, some relatively simple and partly unvalidated models have been used in order to make the analysis practicable.


Background: During the Covid-19 pandemic nursing students experienced anxiety during clinical learning. The existence of high self-efficacy can manage and control themselves when students experience difficult situations, so that they can push their feelings of stress such as anxiety. The aim of the study is to find out the relationship of self-efficacy with the level of anxiety of students practicing the nursing profession of Manado during the COVID-19 pandemic. The method used in this research is quantitative correlation with a cross sectional study approach and used the General Self Efficacy Scale and Hamilton Anxiety Rating Scale questionnaires. The sample of this research consists of 44 samples using total sampling as a sampling techniques. The data analysis was used using frequency distribution and bivariate analysis using spearman's test. The results with a significant value 0.000 or smaller than the significant value 0.05 (0.00 < 0.05), so that there is a relationship between self-efficacy and the level of anxiety of the Manado Nurses Professional Practice students during the COVID-19 pandemic. The conclusion high self-efficacy can reduce the risk of anxiety in nursing professional practice students in hospitals during the Covid-19 pandemic, so that it is hoped that it will have an impact on efforts to improve health services in terms of providing nursing care by nursing professional practice students to further improve self-efficacy so that the risk of experiencing anxiety is reduced and can carry out nursing professional practice more optimally during the Covid-19 pandemic.


Three-level NPC inverters have been put into practical use for years especially in high voltage high power grids. This paper researches three-level active power filters (APFs). In this paper a mathematical model in the d-q coordinates is presented for 3-phase 3-wire NPC APFs. The deadbeat control scheme is obtained by using state equations. Canceling the delay of one sampling period and providing the predictive value of the harmonic current is a key problem of the deadbeat control. Based on this deadbeat control, the predictive output current value is obtained by the state observer. The delay of one sampling period is remedied in this digital control system by the state observer. The predictive harmonic command current value is obtained by the repetitive predictor synchronously. The repetitive predictor can achieve a better prediction of the harmonic current with the same sampling frequency, thus improving the overall performance of the system. The experiment results indicate that the steady-state accuracy and the dynamic response are both satisfying when the proposed control scheme is implemented.


Except as a marker of cancer progression, gamma‐synuclein (GSyn) had received little attention. Recent data showed however that GSyn modulates cocaine‐induced locomotor effects, suggesting that it could also play a role in cocaine reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected in the nucleus accumbens and cocaine reinforcing effects were evaluated by means of intravenous self‐administration. A dose‐response curve was followed by procedures of progressive ratio, extinction, cocaine‐ and cue‐induced reinstatements. Decrease of GSyn expression increased self‐administration over a large range of doses. This effect was associated with an increase in cocaine‐induced reinstatement. The present data reveal that GSyn exert a specific negative control on cocaine‐induced reinforcing and incentive effects.


As we have shown in the past, acute rejection‐related TNF‐α upregulation in resident macrophages in the tunica muscularis after small bowel transplantation (SBTx) results in local amplification of inflammation, decisively contributing to graft dysmotility. Therefore, the aim of this study is to investigate the effectiveness of the chimeric‐monoclonal‐anti‐TNF‐α antibody infliximab as perioperative single shot treatment addressing inflammatory processes during acute rejection early after transplantation. Orthotopic, isogenic and allogenic SBTx was performed in rats (BN‐Lewis/BN‐BN) with infliximab treatment. Vehicle and IV‐immunoglobulin‐treated animals served as controls. Animals were sacrificed after 24 and 168 h. Leukocyte infiltration was investigated in muscularis whole mounts by immunohistochemistry, mediator mRNA expression by Real‐Time‐RT‐PCR, apoptosis by TUNEL and smooth muscle contractility in a standard organ bath. Both, infliximab and Sandoglobulin® revealed antiinflammatory effects. Infliximab resulted in significantly less leukocyte infiltration compared to allogenic controls and IV‐immunoglobulin, which was accompanied by lower gene expression of MCP‐1 (24 h), IFN‐γ (168 h) and infiltration of CD8‐positive cells. Smooth muscle contractility improved significantly after 24 h compared to all controls in infliximab treated animals accompanied by lower iNOS expression. Perioperative treatment with infliximab is a possible pharmaceutical approach to overcome graft dysmotility early after SBTx.


1* Introduction* In a recent paper (2), Cameron and Storvick treat a Banach algebra S of functions on Wiener space which are a kind of stochastic Fourier transform of Borel measures on L2(a, &). (Precise definitions will be given in the next section.) For such functions they show that the analytic Feynman integral, defined by analytic continuation of the Wiener integral, exists, and they give a formula for this Feynman integral. The work in (2) is related to Albeverio and Hώegh-Krohn's beautiful theory (1) of infinite dimensional oscillatory integrals ("Fresnel integrals") as well as to (5). Cameron and Storvick's work is highly promising and has some appealing features. For example, as we will show in a later note, the existence of the Feynman integral for certain qudratic potentials can be established without having to construct special spaces, quad- ratic forms, etc. to fit the particular problem of interest. The main purpose of this note is to show that a crucial part of (2) can be substantially simplified. Let R, C denote the real and complex numbers respectively. Let θ map (α, b) x R to C. Let C(a, b) denote Wiener space; that is, the space of R-valued continuous functions on (α, b) which vanish at α. Let m denote Wiener measure on C(a, &). Under certain hypotheses on θ, Cameron and Storvick show that the function


Familial Hypercholesterolaemia – Epidemiology, Diagnostics and Therapy. Familial hypercholesterolaemia (FH) is an autosomal dominant genetic disorder associated with markedly elevated levels of LDL-cholesterol caused by mutations of the genes encoding for the LDL-receptor, apolipoprotein B or PCSK9. Patients with FH show an increased risk of premature cardiovascular disease. The biggest challenge to date is diagnosing the disease early to start intense lipid-lowering therapy in order to reach treatment goals. Genetic testing and cascade-screening helps to identify patients and to start treatment in time. Beside the combination therapy with high dose statins and ezetimibe, the PCSK9-inhibitors alirocumab and evolocumab are highly effective therapeutics for this patient group. J Kardiol 2017; 24 (7–8): 153–9.


The invention discloses a continuous extrusion method. The method comprises the steps that a wheel belt type continuous casting method is firstly adopted, and under the condition that pouring temperature is 680-1,180 DEG C and the rotating linear speed of a casting wheel is 10-50 m/min, molten metal is poured into a square crystallization cavity formed by a casting wheel groove and a steel belt of a wheel belt type continuous casting machine, and a square casting blank with the height of 20-45 mm and the width of 10-35 mm is obtained through continuous casting; and then the square casting blank is directly conveyed into a continuous extrusion machine from the wheel belt type continuous casting machine, and under the condition that the rotating linear speed of an extrusion wheel of the continuous extrusion machine is 10-50 m/min, the square casting blank is continuously extruded into the needed shape. Due to the fact that the wheel belt type continuous casting method is adopted for casting molten metal into the square casting blank and then directly conveying the square casting blank into the continuous extrusion machine for continuous extrusion forming, and continuous casting and continuous extrusion of the square casting blank are integrated and continuous, and therefore production procedures are fewer, the technological process is shorter, and production efficiency is greatly improved.


Primary hypothyroidism is a common endocrine disorder that is effectively treated with l-thyroxine (T4) replacement. Preclinical and limited clinical evidence, however, indicates that T4 is a growth factor for a variety of cancers, acting at the thyroid hormone receptor on plasma membrane integrin αvβ3. T4 is the primary ligand for this receptor, whereas 3,5,3′-triiodo-l-thyronine (T3) is the principal intracellular thyroid hormone analogue. The evidence is reviewed here that T4 is a proliferative for breast, lung, kidney and prostate cancers and for glioblastoma, regulates cancer cell respiration and is a pro-angiogenic factor in established tumors. The recommendation is made that T3 be considered alternative replacement treatment for patients with primary hypothyroidism who also have cancer.


DT time scans for different temperatures. The pump pulse generates a carrier density that is less than one electron-hale pair per dot in the GaAs barrierlayers. As the temperature is increased, the averallmagnitudeofbaththen=Zandn= 1 sig~ nals decreases significantly indicating that carriers leave the dot levels. In order to observe di~ rectly the thermal reemission of the carriers from the confined dot states to higher-lying states. we perform the DT scans on the energy states within 220 meV of the GaAs bandedge. These results show in Fig. 2 that at low temperatures, the carriers generated in the barrier region all relax down into the low-lying WL and dot levels. Above 120 K, a significant number of carriers OCCUQ~ the WL/barrier regions. We model the above observed temperaturedependent carrier dynamics using a detailed ensemble Monte Carla simulation that accounts for random scattering events! In Figs. IC) and d), we pravideasetofsimulationresults that wellmatch the main dynamical features of then = 2 and n = I DT data. It is found that in order to account for the reduction of the dot level population and the occupation of the Wubarrier states, a reemission term is absolutely necessary. Also, to account for the overall loss of signal at the highest temperatures nonradiative recombination terms are required.


I am certain that you have been there. There is a hush as the surgery proceeds; the quiet interrupted only occasionally by the words "artery forceps" and "diathermy, please". You're resting, perched on your stool and listening to the reassuring sound of bleeps from the ECG monitor. Then suddenly the patient moves and the bellow of "the patient is awake" resounds from beyond the green drapes.


In crisis periods many malfunctions affect the economic environment. The forecasting process is also influence by the negative evolution of the macroeconomic variables. It is hard to predict the economic behavior of many indicators because of the lack of stability of the economic world. It is clear that the forecasts accuracy decreases during the crisis periods, this phenomenon being seen in the activity of international institutions specialized in providing macroeconomic forecasts for different countries or regions. Therefore, we try to solve this problem, by finding suitable strategies or ways of improving the predictions accuracy during the economic crisis. We will start from the forecasts made by international institutions.


Known to all his friends as "Bob," and loved and esteemed by everyone, one of the sweetest and most gentle of characters, he could claim the affection of all those who came in contact with him, adults as well as children.


In the field of the embedded applications,Data Acquisition has occupy a very important position.Various Signal Acquisi-tion of automatic control,access and monitoring of remote data,intelligent recognition of voice and images,All this need to access to information from the outside,and that is all major work of Data Acquisition.This paper focus primarily on universal models of data acquisition from analog to digital in embedded systems,and especially key technology of ADC applications,testing analysis of quick interruption and interrupt sharing and ADC interruption in Linux systems;in the end introduces methods of dynamic display of data with popular graphics library of QT/embedded


A flow cytometry method was developed for rapid screeningand recovery of cloned DNA containing common sequence motifs. Thisapproach, termed fluorescence-activated cell sorting-assisted cloning,was used to recover sequences affiliated with a unique lineage within theBacteroidetes not abundant in a clone library of environmental 16S rRNAgenes. Retrieval and sequence analysis of phylogenetically informativegenes has become a standard cultivation-independent technique toinvestigate microbial diversity in nature (7, 18). Genes encoding the 16SrRNA, because of the relative ease of their selective amplification, havebeen most frequently employed for general diversity surveys (16).Environmental studies have also focused on specific subpopulationsaffiliated with a phylogenetic group or identified by genes encodingspecific metabolic functions (e.g., ammonia oxidation, sulfaterespiration, and nitrate reduction) (8,15,20). However, specificpopulations may be of low abundance (1,23), or the genes encodingspecific metabolic functions may be insufficiently conserved to providepriming sites for general PCR amplification. Three general approacheshave been used to obtain 16S rRNA sequence information from low-abundancepopulations: screening hundreds to thousands of clones in a general 16SrRNA gene library (21), flow cytometric sorting of a subpopulation ofenvironmentally derived cells labeled by fluorescent in situhybridization (FISH) (27), or selective PCR amplification using primersspecific for the subpopulation (2,23). While the first approach is simplytime-consuming and tedious, the second hasmore » been restricted to fairlylarge and strongly fluorescent cells from aquatic samples (5, 27). Thethird approach often generates fragments of only a few hundred bases dueto the limited number of specific priming sites. Partial sequenceinformation often degrades analysis, obscuring or distorting thephylogenetic placement of the new sequences (11, 20). A more robustcharacterization of environ mental microbiota would be enabled by amethod to retrieve near-full-length copies of selected genes from rarepopulations, not restricted to the analysis of genes encoding the rRNAs.We recently demonstrated the use of FISH of 16S rRNA gene clones(clone-FISH) to screen an environmental clone library using microscopy(24). A similar protocol has been more recently published by Ouverney etal. (17). In this study, we evaluated the combination of clone-FISH andflow cytometry to screen and sort a 16S rRNA gene clone library (termedfluorescence-activated cell sorting-assisted cloning [FACS-cloning]). Aprobe targeting most of the Cytophaga-Flavobacterium cluster of thephylum Bacteroidetes was used to recover near-full-length 16S rRNA genesequences affiliated with this group not abundant in the original clonelibrary.« less


Coastal erosion has become an issue globally. As the sea level continues to rise due to global warming, projections are that erosion would increase. To address the issue sustainably, relevant scientific information such as sediment transport and shoreline dynamics is required at local scales. Over the years, erosion at the eastern coast of Ghana has been mainly evaluated using low-resolution imagery due to the challenges in retrieving high-resolution data in the nearshore region. An unmanned aerial vehicle (UAV) approach was used to assess beach evolution on a seasonal and short-term basis between May 2018 and December 2019. Using the UAV approach, shoreline changes, sediment volume changes, and profile elevation parameters were extracted for the Dzita beach of Ghana. Shoreline changes indicated the dominance of erosion during the first and third phases (May 2018 to December 2018 and June 2019 to December 2019, respectively) at a rate of −7.23 ± 0.23 and −4.85 ± 0.23 m/yr, whereas the second phase showed accretion of +8.44 ± 0.23 m/yr. Beach profiles from the first, second, and third phases had steep and gentle slopes, respectively. From these observations, it was recommended that soft engineering approaches such as beach nourishment should be implemented to protect the shoreline and strict prevention of nearshore sand mining and gravel mining. It is also possible that the beach could go through a cycle of changes. Further studies using this same approach should be done as well as probing into other parameters such as nearshore bathymetry to have a better understanding of beach dynamics as envisaged.


The situation has prompted the liberalization of university orientation studies on themanagementof thecollege who efekltif and efficient, especially for University High State . Higher education which in the previous period tended to focus on the technical dimension, needed to reform by providing goodservices so as to give satisfaction to students. The research aims to produce outcomes in the form of a measuringinstrument that will be used by the University of Nusa Cendana Kupang, Postgraduate Program to conductan assessment on student satisfaction in undergoing lectures. This research was carried out through two stages ofresearch. The first year aims to 1) Identify the expectations of students when carrying out lectures, so it can bedetermined factors of student satisfaction; 2) Conducting a factor analysis to determine the dimensionsof Postgraduate service quality especially public administration study program in the last 3 (three) years i.e.from 2016 to 2018 in the Undana Postgraduate Program. This research is a research in the first year preceded byan exploratory method which is then followed by a factor of analysis to classify factors of higher educationservice quality based on student perceptions. Based on the service quality measurement model compiled, then aconfirmatory analysis was carried out by testing the model based on the distribution of questionnaires fora confirmatory analysis.Keywords: analysis exploratory, confirmatory, service quality


Abstract Results of increment corings from 85 trees, together with field studies, indicate a pioneer role for the species, suggesting that periodic site disturbance is necessary for regeneration of the species. Counting and measuring of groups of rings in the increment cores show that interpretation of long-term climatic fluctuations is not reliable. Results in this respect therefore concur with those of Scott (1972).


Abstract : A FORTRAN COntrol Program for Engineering Synthesis (COPES) is presented for solving engineering design problems. This program uses the general-purpose optimization code ADS (Automated Design Synthesis) to provide a versatile design optimization capability. The program minimizes or maximizes a numerically defined objective function subject to a set of constraint limits. In addition to direct optimization, COPES includes approximation techniques as well as the capability to perform conventional parametric studies. Programming guidelines are presented, followed by sample input data and output for the various program options. (Author)


Non-blazar AGN have been recently established as a class of gammaray sources. M87, a nearby representative of this class, show fast TeV variability on timescales of a few days. We suggest a scenario of flare gamma-ray emission in
non-blazar AGN based on a red giant interacting with the jet at the base. We solve the hydrodynamical equations that describe the evolution of the envelope of a red giant blown by the impact of the jet. If the red giant is at least slightly tidally disrupted by the supermassive black hole, enough stellar material will be blown by the jet, expanding quickly until a significant part of the jet is shocked. This process can render suitable conditions for energy dissipation and proton acceleration, which could explain the detected day-scale TeV flares from M87 via proton-proton
collisions. Since the produced radiation would be unbeamed, such an event should be mostly detected from non-blazar AGN. They may be frequent phenomena, detectable in the GeV-TeV range even up to distances of ∼ 1Gpc for the most powerful jets. The counterparts at lower energies are expected to be not too bright. M87, and nearby non-blazar AGN in general, can be fast variable sources of gamma rays
through red-giant–jet interactions.


Although a growing body of scholarship examines who believes conspiracy theories (CTs) and why, less is known about why people share CTs. We test the impact of three independent motives on people's willingness to share CTs on social media: bolstering their or their group's beliefs (motivated sharing), generating collective action against their political outgroup because of losing (sounding the alarm), and mobilizing others against the political system (need for chaos). Using an original survey of US adults ( N = 3336), we test these three motives together and find strong evidence for motivated sharing and need for chaos, but no evidence for sounding the alarm. Our findings suggest that motivated sharing—when measured directly as belief in the CTs—is the strongest predictor of willingness to share CTs on social media. Need for chaos has less of an effect on sharing than belief but a consistently stronger effect on sharing than partisanship and ideology. Altogether, we demonstrate that sharing CTs on social media can serve both motivated and mobilizing functions, particularly for those who believe the CTs or seek to challenge the political system, rather than impugn their political rivals.


Buddhist music was introduced into China along with Buddhism. Since the introduction of Buddhist music, it has combined with local folk music in China and has gradually formed a kind of Buddhist music with special local characteristics. Chongqing Luohan Temple is one of the famous Buddhist shrines in China. Since the 1980s, the Buddhist music of Chongqing Luohan Temple has been recorded and collected in academia. This paper intends to select the old music version of Yoga flaming mouth ceremony in 1987 and the new version in 2012, and find the conservatism and evolution of Buddhist music in Chongqing Luohan Temple by comparing with the two versions: the conservative form of the Buddhist music shows the continuation of the Buddhist music of Chongqing Luohan Temple; the spiritual transformation of the Buddhist music shows the evolution of the Buddhist music of Chongqing Luohan Temple; the Buddhist music of Chongqing Luohan Temple has educational characteristics that are the unity of cultivating humanity and artistry, the unity of external convention and internal morality, and the unity of paying attention to results and focusing on the process.


There is a pressing demand for new sustainable eco-friendly approaches to producing green energy worldwide. This study represents the novel production of biodiesel feedstock from the medicinal mushroom Ganoderma lucidum QRS 5120 using state-of-the-art biotechnology tools. Response surface methodology (RSM) was used to enhance G. lucidum production in a repeated-batch fermentation strategy. By referring to the broth replacement ratio (BRR) and broth replacement time point (BRTP), RSM that was formulated using a central composite design (CCD) resulted in a significant model for all tested variables, which are exopolysaccharide (EPS), endopolysaccharide (ENS) and biomass, with BRR (%) of 60, 75 and 90, and BRTP (days) of 11, 13 and 15. The model was validated using the optimised conditions, and the results showed 4.21 g/L of EPS (BRR 77.46% and BRTP 12 days), 2.44 g/L of ENS (BRR 60% and BRTP 12.85 days), and 34.32 g/L of biomass (BRR 89.52% and BRTP 10.96 days) were produced. Biomass produced from the G. lucidum was subsequently used as feedstock for biodiesel production. Approximately 20.36% of lipid was successfully extracted from the dried G. lucidum biomass via a solvent extraction and subsequently converted to Ganodiesel through a transesterification process. The Ganodiesel produced fulfilled most of the international standards, i.e., US (ASTM D6751-08) and EU (EN 14214). Overall, this study demonstrates the optimised G. lucidum production and its lipid production as a new biodiesel feedstock.


The title compound, bis[4,4′-(propane-1,3-diyl)dipiperidinium] β-octamolybdate(VI), (C13H28N2)2[Mo8O26], was produced by hydrothermal reaction of an acidified aqueous solution of Na2MoO4·2H2O and 4,4′-trimethylenedipiperidine (L). The structure of the title compound consists of β-octamolybdate(VI) anion clusters and protonated [H2 L]2+ cations. The octamolybdate anion is located around an inversion center. N—H⋯O hydrogen bonds between the cations and anions ensure the cohesion of the structure and result in a three-dimensional network.


Despite electrocardiography's respectable age of more than 100 years (mass production of the first electrocardiographs began in 1905), electrocardiography has remained the most widespread, accessible, and inexpensive method to study the heart objectively. According to the well-known Israeli scientist S. Stern 'Electrocardiogram: Still the Cardiologist's Best Friend' [1]. Naturally, this area continues to attract significant financial and intellectual resources and occupies the sizable part of a medical industry. Over the past 10–15 years, electrocardiography has experienced several innovative breakthroughs [2] below:


The effects of a static low-intensity electromagnetic field (EMF) on higher plants were investigated. Thai basil (Ocimum basilicum var. thyrsiflora) and waxy corn (Zea mays var. ceratina) were chosen as samples for the experiments. There were 2 methods of electromagnetic exposure, indirect exposure (applying magnetically treated water to plants) and direct exposure (plants are grown under the electromagnetic field). For the indirect exposure experiment, magnetically treated water (0.34-4.54 mT, 24 h) was applied to Thai basil seeds daily for 1 week and the experiment was repeated once. No significant difference in the heights was found between the control groups and the treated groups whether deionized or tap water was used. For the direct exposure experiment (0.28-3.83 mT), waxy corn seeds were grown between a pair of electromagnets. Two controls were grown in the absence of an extra magnetic field; 1 control group (no electromagnets (EM)) was grown at room temperature while the other control group (EM-0) was grown between a pair of electromagnets with a similar temperature to the other magnetically treated groups. The experiment was completed in 4 days and was repeated once. The results indicated that there is no height difference between the control (EM-0) and the groups grown between electromagnets; however, the controls (no EM), which were grown at room temperature were shorter compared to those grown between electromagnets. Our results suggest that the level of the applied magnetic field has no effect on the heights of the plants in this study.


Glucose homeostasis is a complex mechanism that requires the interplay between different organs. The kidney plays a central role in this process by re‐absorbing 99.5% of the filtered glucose in the proximal tubules, where SGLT1 and SGLT2 use the energy provided by the electrochemical gradient of sodium to drive glucose transport.


Br J Surg 2016; 103: e12-e15 DOI: 10.1002/bjs.10033 The sentences below were omitted from the final paragraph of the original version of this paper. Examples are to consider postponement of surgery to allow high-risk patients to get fit first, and to stimulate collective participation in all sorts of (physical) activities of daily living in the surgical ward after surgery. It is preferable for the patient to mobilize constantly rather than to train on a one-to-one basis in short sessions at the department of physical therapy, and to separate bed and television, a combination that encourages sedentary behaviour.


My diploma thesis "Employment project for disabled people'q deals with problems of employment of disabled people discriminated on the labour market because of their state of health. In the theoretical part of my thesis, theoretical questions concerning disabled people and their employment are summarized. The practical part is focused on AGROBEN cooperative establishment and is divided into two parts, analysis and project. The background analysis covers finding and evaluation of the current state of human resource management, personnel structure and attitude of the employees concerning employment of disabled people. In the second part, the employment project for disabled people in AGROBEN cooperative establishment is developed. Subsequently, this project is subjected to cost, risk and time analysis.


BACKGROUND
Facioscapulohumeral muscular dystrophy (FSHD) is a progressive myopathy caused by misexpression of the double homeobox 4 (DUX4) embryonic transcription factor in skeletal muscle. Identifying quantitative and minimally invasive FSHD biomarkers to report on DUX4 activity will significantly accelerate therapeutic development.

OBJECTIVE
The goal of this study was to analyze secreted proteins known to be induced by DUX4 using the commercially available Olink Proteomics platform in order to identify potential blood-based molecular FSHD biomarkers.

METHODS
We used high-throughput, multiplex immunoassays from Olink Proteomics to measure the levels of several known DUX4-induced genes in a cellular myoblast model of FSHD, in FSHD patient-derived myotube cell cultures, and in serum from individuals with FSHD. Levels of other proteins on the Olink Proteomics panels containing these DUX4 targets were also examined in secondary exploratory analysis.

RESULTS
Placental alkaline phosphatase (ALPP) levels correlated with DUX4 expression in both cell-based FSHD systems but did not distinguish FSHD patient serum from unaffected controls.

CONCLUSIONS
ALPP, as measured with the Olink Proteomics platform, is not a promising FSHD serum biomarker candidate but could be utilized to evaluate DUX4 activity in discovery research efforts.


Objective To assess the relation and clinical significance between E-Cadherin expression and the biological behavior of bladder transitional cell carcinoma. Methods Immunohistochemical method was used to detect E-Cadherin in 63 cases of bladder transitional cell carcinoma and 6 normal bladder biopsies as controls.The results were analyzed,and combinated with clinical and pathological data. Results Normal E-Cadherin expression was found in all the 6 normal bladder membranous tissues.Abnormal E-Cadherin expression was found in 42 cases of bladder cancer (66.7%) indicating that abnormal E-Cadherin expression correlates with both increased grade,stage,high recurrence and poor survival. Conclusions E-Cadherin expression is closely related to the malignant progression of bladder cancer.The detect of E-Cadherin expression is helpful in predicting the biological behavior of bladder transitional cell carcinoma.Therefore,E-Cadherin could be used as an useful molecular marker for predicting the progression,recurrence and prognosis of bladder transitional cell carcinoma.


As patient care shifted from hospital to ambulatory settings during the past 2 decades, medical schools increased student education in those settings. From 1986–87 to 1996–97, the time students spent in ambulatory settings during their internal medicine clerkships increased from 6% to 28%.1 Although medical students seem satisfied with training in the ambulatory setting,2 there is concern that student education may have a negative impact on patient satisfaction.

Previous studies found that student involvement had little influence on patient satisfaction.3–5 These studies were observational studies subject to bias,6 even though they were well-designed observational studies. Randomized controlled trials are difficult to do in medical education. Small numbers of potential participants at any one institution and practical issues of modifying educational programs and clinical settings for research purposes hinder most educational research.

In this issue of the Journal of General Internal Medicine, Gress et al. report the first randomized controlled trial of the effects of medical students' involvement in ambulatory care visits.7 This study is an example of a creative and exceptionally well-designed educational study. Gress et al. randomly assigned patients to one of two study groups: 1) attending physician only or 2) attending physician plus medical student. Random assignment was done in pairs to further control for potential bias from visit type (new versus return), attending physician, and date of visit. This produced 2 groups of patients that were equivalent in characteristics that might influence patient satisfaction (age, sex, income). A staged interview was done to preserve blinding of study group assignment during questioning about satisfaction with the visit, and there were specific questions related to patients' satisfaction with the medical student. These interviews were done by telephone within 72 hours of the visit, so patients were not influenced by the office setting.

Similar to prior studies, Gress et al. found no significant differences in global patient satisfaction ratings between the two study groups. Approximately 80% to 85% of patients rated their physician as "excellent" and 85% rated the overall office visit as "excellent" or "very good." However, when patients were asked directly about the medical student, only 26% of patients rated the student as "excellent," and another 44% rated the student as "very good." More importantly, 30% of patients indicated that they would "probably not" or "definitely not" want a similar arrangement where they would be seen by a doctor in training, and 17% would not recommend this arrangement to a friend or family member. The latter percentages are striking because these patients agreed to be seen by a medical student and participated in the study.

Clearly, this study needs to be replicated at other institutions and in other ambulatory settings (e.g., community-based offices, health maintenance organizations, family medicine and pediatric practices) to determine if the findings are robust. The authors describe in their discussion several limitations of their study that should to be addressed in future studies: a small sample size that limits the statistical power of the study, and 4 attending physicians and 4 medical students at a single academic general internal medicine practice that limits the generalizability of the results. This study also indicates that global patient satisfaction measures do not detect patients' dissatisfaction with trainee involvement in their care. New measures that are specific to student involvement in patients' care, such as the ones used in this study, should be used.

Most provocative studies raise more questions than they answer. This study is no exception. We do not know why patients who initially agreed to be seen by a medical student would or would not want to be seen by a student again. The answers to this question are important. These data would assist preceptors in selecting patients for students and educators in developing approaches for enhancing student–patient interactions. To give us a complete picture of medical education in ambulatory settings, we also need studies that explore the "value added" to patient care by trainees and the impact on job satisfaction for clinicians. Finally, we do not know if these reactions are specific to ambulatory settings. Patients may have similar reactions to medical student involvement in hospital settings.

What do we do in the meantime? We continue to be sensitive to patients' wishes and reactions regarding trainees' involvement in their care, no matter what the setting.


In recent years, widespread belief among biology teachers and educational researchers is the need of revising in-class activities for teaching meaningful scientific content and developing conceptual understanding. This belief focuses on rather than learning every piece of information; quality than quantity; making sense than memorizing; understanding than being aware of knowledge. Although the revised curriculum aims to train students in desired ways, studies on understanding and explaining biological phenomena revealed that, students have limited understanding and alternative conceptions even about the most biological processes. The implementation and the education effectiveness of new and different methods to make students love biology, teach them better, to develop a scientific conception in desired standards and ways are important. For this purpose, this study aims to find out the applicability of DNR-based teaching that was developed previously in mathematics education to teach and learn biology in digestive process and human digestive system.


In massive text information, text classification can better help people organize and manage the mass of text information. In real life, a text often belongs to a number of categories. For this classification scenario, it is called a multi-label classification. Existing text multi-label classification methods rarely take into account the correlation between labels, and lack the understanding of the label semantics. In this paper we propose a method of text multi-label learning based on label correlation, modeling between texts and label vector through neural networks, and capture the semantic correlation between text and labels. A large number of experiments show the effectiveness of the method, especially when the amount of data is large.


Objective To identify the prevalence of childhood autism in Tianjin,in order to get evidences for preventing and recovering from autism. Methods 7 316 children aged 2 to 6 years in two districts in Tianjin were randomly surveyed. Results 8 of the 7 916 children were diagnosed as autism with a prevalence of 1.1 ‰.The gender ratio is 7∶1.The urban and rural prevalence are 1.4 ‰ and 0.8 ‰,respectively,and no statistical difference is found.All the autism patients are mental retardation(IQ70),and their MR degree is generally higher than other non-autism MR children. Conclusion Accurate intervention measure should be taken to improve mental,and neuropathic and psychiatric,impairments of the autism children.


Effective population size affects the efficacy of selection, rate of evolution by drift, and neutral diversity levels. When species are subdivided into multiple populations connected by gene flow, evolutionary processes can depend on global or local effective population sizes. Theory predicts that high levels of diversity might be maintained by gene flow, even very low levels of gene flow, consistent with species long-term effective population size, but tests of this idea are mostly lacking. Here, we show that Lycaeides butterfly populations maintain low contemporary (variance) effective population sizes (e.g., ∼200 individuals) and thus evolve rapidly by genetic drift. Contemporary effective sizes were consistent with local census populations sizes. In contrast, populations harbored high levels of genetic diversity consistent with an effective population size several orders of magnitude larger. We hypothesized that the differences in the magnitude and variability of contemporary versus long-term effective population sizes were caused by gene flow of sufficient magnitude to maintain diversity but only subtly affect evolution on generational time scales. Consistent with this hypothesis, we detected low but non-trivial gene flow among populations. Furthermore, using population-genomic time-series data, we documented patterns consistent with predictions from this hypothesis, including a weak but detectable excess of evolutionary change in the direction of the mean (migrant gene pool) allele frequencies across populations, and consistency in the direction of allele frequency change over time. The documented decoupling of diversity levels and short-term change by drift in Lycaeides has implications for our understanding of contemporary evolution and the maintenance of genetic variation in the wild.


Ankle arthroplasty is known to become more successful procedure versus ankle fusion in patients with ankle osteoarthritis. This article represents a clinical case of performing three-staged bilateral ankle arthroplasty by means of HINTEGRA and Mobility implants in a patient with severe defect of the talus. The patient was followed up for 2 years for right ankle and 4 years - for left ankle. The correct treatment strategy gave the patient a new lease of life. He resumed sports activities, being pain-free in both the ankle joints.


Current statistical machine translation (SMT) systems are trained on sentence-aligned and word-aligned parallel text collected from various sources. Translation model parameters are estimated from the word alignments, and the quality of the translations on a given test set depends on the parameter estimates. There are at least two factors affecting the parameter estimation: domain match and training data quality. This paper describes a novel approach for automatically detecting and down-weighing certain parts of the training corpus by assigning a weight to each sentence in the training bitext so as to optimize a discriminative objective function on a designated tuning set. This way, the proposed method can limit the negative effects of low quality training data, and can adapt the translation model to the domain of interest. It is shown that such discriminative corpus weights can provide significant improvements in Arabic-English translation on various conditions, using a state-of-the-art SMT system.


Hydrothemal Liquefaction (HTL) of empty fruit bunch (EFB) of palm oil in different solvents (water, ethanol and hexane) were comparatively investigated. Experiments were carried out in an autoclave in different EFB loading of 9%, 11%, and 13%. The temperature operation was 350 oC, without any catalysts and reaction time of 5 hours. The efficiency of above solvents in terms of conversion rate, soluble liquid and carbon products were found in this experiments. The water solvent gave higher conversion rate of 35 – 36.5 %, while hexane gave conversion of 17 – 25.25 %, and ethanol gave the lower conversion rate of 12.65 – 30.3%, respectively. Increasing the EFB load decreased the conversion rate for ethanol and hexane solvents, for water there are no significant change in the conversion rate. The bio-oil as soluble liquid produced were in order of water, ethanol, and hexane solvents, respectively. The chemical properties of bio-oil products were significantly affected by the type of liquefaction solvent. The c...


51]). But let's be fair: so do we in literature departments, perhaps especially if we're committed to a "theory." It's one thing, though, to "argue that Huckleberry's sympathy is sufficient for his own heroism, although his moral status would be much higher if it derived from moral principle" (Lyon 41)—in his greatest crisis, alas, Huck has no principles—and quite another to offer, as Gehrman does, "a developmentally attuned perspective on Huck's character and his moral capacities" (55). Taking cues from Aristotle and Iris Murdoch, she tracks "the tale of a traumatized child whose upbringing has left him deeply damaged: he is largely bewildered about the difference between right and wrong, he is incapable of acting in ways that are consistent with his own choices and values, and he is just as racist as the other White members of his community" (56). I might quibble with some of that ("incapable of acting"?), but Gehrman does get into the dynamic movement of "Huck's story" and make her case that the "greatness" of Huck Finn "is not triumphant or celebratory, but rather Socratic —to provoke and humiliate us "for the good of [our] souls" (63). She makes a useful contribution to our discussions — our and our students' understanding and knowing—of a book we shall not soon "get shut of." Gehrman's is the best essay in Part I and perhaps in the book, but it's not the only one I learned something from; indeed all of them might inform an interested reader of Twain, or provoke slower and closer re-reading of Huck Finn or any other text they take up. Are they "good philosophy"? My philosophy friends will have to judge that. For my part, I value James McLachlan's "Mark Twain and the Problem of Evil," Brian Earl Johnson's "The American Diogenes," and Jeffrey Dueck's "Making the Heart Grow Fonder" as informative, well-written, and generative.


Crude Oil is a commodity with huge strategic importance to all countries in the world. But in the recent years, the oil market as well as all commodities market has crossed an intense period of changes due to a volatile international economic context. After a decade of rapid economic growth rates, China and the other emerging markets are slowing down. After a harsh and unpredictable crisis, the financial and commodity regulation has changed; the uncertainty and distrust have increased, and, implicitly, the prices volatility in financial and commodity markets has also increased. In this paper we empirically investigated the crude oil market price behaviour and proposed an econometrical GARCH model (Engle, 1982; Bollerslev, 1986) to forecast the volatility of this market. Our research questions are how crude oil price volatility has changed in the recent years? In order to answer to this question we developed an empirical analysis using daily future one month quotation of Brent, Dubai and WTI crude oil over the last three years. These quotations were extracted from Thomson-Reuters Database. Our results suggest a relatively small volatility in crude oil market on a short run with a price fluctuation around the level of 110 USD/barrel for Brent crude oil. Moreover, our final conclusion is that: the economic slowdown in emerging markets, but also the new regulations in commodity markets represent new challenges for economists and researchers, and ask for structural reforms to adjust to new context.


This paper investigates and comparatively analyzes the students' qualities of ideological and political theory in polytechnic institutes and universities,then summerizes the main characteristics and deficiencies of higher vocational students.Simultaneously,it gives suggestions on constucting the teaching system of basic courses with higher vocational education characteristics.


Translocations involving human immunoglobulin heavy chain (IGH) locus are implicated in different leukaemias and lymphomas, including multiple myeloma, mantle cell lymphoma, Burkitt's lymphoma and diffuse large B cell lymphoma. We have analysed published data and identified eleven breakpoint cluster regions (bcr) related to these cancers within the IgH locus. These ~1 kbp bcrs are specific for one or several types of blood cancer. Our findings could help devise PCR-based assays to detect cancer-related translocations, to identify the mechanisms of translocations and to help in the research of potential translocation partners of the immunoglobulin locus at different stages of B-cell differentiation.


The author discusses the original paper ("Ampacity of diversely loaded cables in covered and uncovered trays", W.Z. Black et al., see ibid., vol. 15, no. 1, p. 3-7, 2000) and presents his observations. The original authors' response to the discussion is also included.


The monograph was prepared to educate agricultural advisors and farmers on the ways of pollution of ground and surface water with plant protection products (PPP) and to present the techniques for the prevention of their water pollution. It was prepared for the project SI-MUR-AT, an EU Cooperation Program INTERREG Slovenia-Austria 2014 – 2020. In the first part, the transition paths of PPP into the water are presented (leaching through the profile of the soil, surface run-off and point source pollution). The importance of soil's pedological and hydrological characteristics for limiting PPP leaching and the methods for reducing the passage of PPP into the water are also presented. These are: the modified methods of PPP use and of rotation with preparations, improved risk analysis for leaching and runoff of PPP, changed methods of soil tillage, adapted application methods of PPP in the vicinity of surface water to reduce drift,  retention measures for prevention of water runoff from arable land into the drain ditches and increased use of mechanical methods of weed control.


By analyzing scaling mechanism and the property of profile control agent,this paper presents technique for Cr3+ polymer gel of improving fluid entry profile of injection well in weak alkali ASP flooding.The optional formula,property evaluation and compatibility condition with weak alkali ASP flooding of polymer gel are studied and tested in Beisanxi P56 pilot of Daqing oilfield.The results of pilot test shows the polymer gel has double function of scavenge and blanking off high permeability zone.The fluid entry in high permeability layer is decreased from 100% to 54.9%.


A sensitive fluorometric method was developed for the determination of urea. The method was based on the hydrolyzation of urea catalyzed by urease with pH and the change of fluorescence intensity of sodium fluorescein as a pH sensitive dye in the enzymatic reaction. The increase in fluorescence intensity of sodium fluorescein was measured at λex= 490 nm and λem= 514 nm. Under the optimum conditions the assay responded linearly to urea concentration in the range of 0.25 to 3 mM with a correlation coefficient of 0.996. This study also demonstrated the feasibility of a fluorometric method for urea determination with fiber optic detection. The probe response also displayed good linearity in the range of 0.10 to 1.75 mM urea.


From 1914 to 1920,Zhou En-lai practiced in the associations of Nan Kai and Tian Jin.Through the activities,Zhou En-lai's thought maturated and his great capability was evident.Earlier period association activities of Zhou Enlai will be the approach to the study of young Zhou En-lai.Meanwhile,to expand the connotation of Zhou En-lai' spirit and promote the learning activities of Zhou En-lai will have a great effect on the healthy development of students' associations in universities.


The overall goal of this project is to develop SI traceable measurements for the monitoring and control of mercury (Hg) and its different species in gas emission sources and in the atmosphere. In this way, the project will achieve significant improvements in the measurement comparability and uncertainty of Hg measurement results. Currently, traceable calibration methods only exist for elemental mercury (Hg(0)), however such measurements are also needed for oxidised Hg species, i.e. Hg(II) in order to meet the requirements of EU regulation and the implementation of the Minamata Convention. To address this, the project aims to validate and develop traceable oxidised Hg standards and methods for sampling and analysing oxidised Hg species in flue gas emissions and in the ambient air.


Deregulation of Cdk4 or Cdk6 is central to the loss of cell cycle control in cancer. In myeloma, over-expression of Cdk4-cyclin D1 or Cdk6-cyclin D2 predisposes primary bone marrow (BM) myeloma cells to proliferation in vivo1. Conversely, silencing Cdk4/6 by its physiologic inhibitor, p18INK4c, is required for G1 cell cycle arrest during the generation of normal plasma cells2. Targeting Cdk4/6, therefore, is critical for the control of disease progression and drug resistance in myeloma, but no Cdk4/6-specific inhibitor was available. We have now targeted Cdk4/6 in combination therapy in myeloma using PD 0332991 (Pfizer), a novel orally bioactive, small molecule Cdk4/6-specific inhibitor. We demonstrate that as a single agent, PD 0332991 rapidly inhibits Cdk4/6 (IC50 ∼ 60 nM) and induces exclusive G1 cell cycle arrest in primary human myeloma cells in the presence of BM stromal cells. Non-invasive whole body imaging reveals that PD 0332991 nearly completely prevents tumor growth in a rapidly disseminated xenograft human myeloma model without overt toxicity3. Because PD 0332991 is reversible and does not induce apoptosis when used as a specific Cdk4/6 inhibitor, we have further developed two strategies to target Cdk4/6 in combination therapy. In the first, the release of PD 0332991-induced G1 arrest leads to synchronous S phase reentry and preferential killing of cycling myeloma cells by cytotoxic agents. In the second, prolonging PD 0332991-induced G1 arrest markedly sensitizes primary myeloma cells to killing by cytotoxic agents including the proteasome inhibitors bortezomib and NPI-0052, as well as the steroid dexamethasone. The Cdk4/6-based combination therapy rapidly reduces tumor load in animal models. More importantly, it overcomes drug resistance in primary myeloma cells isolated from refractory relapse patients despite the protection from BM stromal cells. Synergistic killing of myeloma cells lies in the synergistic induction of mitochondria depolarization. Based on this study and the favorable outcome of a PD 0332991 Phase I clinical trial, a Phase I/II PD 0332991-bortezomib clinical trial for myeloma is underway. Targeting Cdk4/6 by PD 0332991 in combination with a selective cytotoxic agent, therefore, represents the first promising cell cycle-based therapy in myeloma, and possibly other cancers.


ObjectiveCompare the difference of the interleukin-6(IL-6) gene promoter methylation between patients with chronic periodontitis and healthy people to find out the relation between IL-6 gene promoter methylation and susceptibility of periodontitis.MethodsCP group,44 patients with periodontitis;H group,45 cases of periodontal healthy persons.DNA was taken by swabbing buccal mucosa exfoliated cells with cotton and was detected by methylation-specific polymerase chain reaction method.ResultsIL-6 promoter methylation was positive in 30 patients of CP group,and the positive rate was 68.18%;H group,IL-6 promoter methylation was positive in 42 persons of H group,and the positive rate was 93.33%.The difference between the two groups had statistical significance(χ~2=9.108,P=0.003).ConclusionIL-6 gene promoter methylation status may be associated with susceptibility of chronic periodontitis.


Through interviews with 35 high-risk college students, the author examines two questions: (a) To what degree do high-risk college students possess self-authoring ways of knowing? and (b) What types of experiences are associated with development of self-authoring ways of knowing? Findings suggest high-risk college students often develop self-authoring ways of knowing prior to enrollment in college, especially if the students possess low levels of privilege. Self-authoring ways of knowing appear to arise from students' willingness to process provocative interpersonal experiences. A model of self-authorship is presented to illustrate these high-risk students' self-authoring processes.


In the films of Ingmar Bergman, children live in a world of tormented innocence. They are surrounded by tortured adults who cannot or will not communicate to them the reasons for their anguish. Distrustfully, the children seek their own answers by observing and eavesdropping on the adult world. They try, as they develop understanding, to personify and simplify good and evil. Like heroes of Greek tragedy, they are driven by curiosity, a need to know.