We present a case of shared psychotic disorder in a mother and her daughter, who is first seen at age of 15 at the Mental Health Unit for an Eating Disorder. She evolved from restrictive anorexia to bulimia, and before the age of 18 a psychotic disorder begins shared with her mother (who is the active member). After a suicidal attempt, related to body image disturbance, she was admitted to hospitalization and we observe how the delusional disorder gets worse in the mother, who rejects therapeutic help.


Writing about life in Mecca in 1884–5 Professor C. Snouck Hurgronje made this observation: "A class of Jâwah who dwell outside the geographical boundaries but who in late years have made regular pilgrimages to Mekka are people from the Cape of Good Hope. They are derived from Malays, formerly brought to the Cape by the Dutch, with a small mixture of Dutch blood. Some words of their Malay speech have passed into the strange, clipped Dutch dialect of the Boers. On the other hand they have exchanged their mother tongue for Cape Dutch, of course retaining many Malay expressions. Taking into consideration the genuinely Dutch names of many of these Ahl Kâf (as they are called in Mekka) one is tempted to believe that degenerated Dutch have been drawn by them into their religion, and many types among them increase the probability of this suggestion. Separated from intercourse with other Moslims they would scarcely have had the moral strength to hold their religion had not eager co-religionists come to them from abroad. When and whence these came is not known to me; however this may be, the mosques in Cape Colony have been more fervently supported in the last twenty years than ever before, more trouble is taken in teaching religion and every year some of the Ahl Kâf fare on pilgrimage to the Holy City."


The effects of pyrolysis pressure and atmosphere on the CO 2 -gasification reactivity of Shenfu char were investigated by using a pressurized-TGA. It is found that tar redeposition and repolymerization which occur during pressurized-pyrolysis under N 2 , i.e. tar secondary reaction, could influence the initial gasification reactivity of char significantly. The tar cracking product produced by tar secondary reaction would cover the surface of char particle and form a less reactive layer, which could overlay the inlet of micro-pores of char particle to decrease the accessibility of reactant to the reactive sites inside the particle and slow down the initial gasification reactivity of char. Hydro-gasification during hydro-pyrolysis consumes the less reactive layer and the carbonaceous part of chars, which forms more reactive sites on chars. Higher hydrogen pressure is favorable for the hydro-gasification and the increase of chars gasification reactivity. Compared with the pyrolysis under N 2 , hydro-pyrolysis is advantageous to increase the gasification reactivity of chars. Under N 2 atmosphere, tar secondary reaction would decrease the reactivity of chars. However, in the case of hydro-pyrolysis, the negative effects brought by tar secondary reaction can be rule out by the activation of the char by the hydrogasification. It is noted that under the experiment conditions used in this study, hydro-pyrolysis is favorable for increasing the gasification reactivity of chars either at atmospheric pressure or at higher pressures.


Ala or blade in at least two segments (1a, 1b) facing, which each include a longitudinal supporting structure (2a, 2b, 22) provided with two hearths (2a, 2b) and at least one stringer (22) binds both hearths, where a connection between the segments includes at least first joints (3a, 3b) connecting the end of the hearths of said face segments to face, characterized by slots disposed between at least one crossbar (22) and screeds (2a, 2b) by reduction of the height of said bar in one part (4a, 4b) for receiving the first joints (3a, 3b), receiving the first joints connecting the crossbeams inside said grooves.


In this article, the outage probability as a standard metric for evaluating the performance of a distributed (or decentralized) Reed-Solomon (R-S) coded cooperative communication system is presented. In this system, the users' codewords are split into two frames and are transmitted via two independent fading paths. The first is directly to the destination while the second frame is transmitted via a relaying partner, also to the destination. The outage probability expressions here derived further prove that the R-S coded scheme achieves full diversity. Moreover, the comparisons under different source-partner and source-destination channel conditions made with the centralized Rate Compatible Punctured Convolutional (RCPC) coded cooperative scheme show that the decentralized R-S coded scheme outperforms the centralized RCPC cooperative scheme. Keywords: coded cooperation, cooperative diversity, outage probability, fading channel, source, partner


Recent work in anthropology points to the recognition of multispecies entanglements as the grounds for a more ethical politics. In this article, we examine efforts to control mosquitoes in Dar es Salaam, Tanzania, as an example of the laborious tasks of disentanglement that characterize public health interventions. The mosquito surveillance and larval elimination practices of an urban malaria control program offer an opportunity to observe how efforts to create distance between species relate to the physical and civic textures of the city. Seen in the particular context of the contemporary African metropolis, the work of public health appears less a matter of control than a commitment to constant urban maintenance and political mobilization.


ABSTRACT

This study aims to find out how the description and comparison of the difficulties of students of SMPN 1 Bontomatene in each steps of solving mathematical literacy problems related to space and shape on students who have spatial ability types of spatial relations, spatial orientation and spatial visualization. This type of research is descriptive research with a qualitative approach. Stages of problem solving are referred to in this research are: (1) Understanding the problem; (2) Devising a plan; (3) Carrying out the plan; and (4) Looking back. This study used 3 types of instruments, namely: (1) Spatial ability test to classify students based on the type of students' spatial ability; (2) Math literacy problem solving test to analyze the difficulties students experience in each problem-solving step; and (3) Interview guidelines are used to delve deeper into the difficulties students experience. Based on the results of data analysis obtained: (1) In understanding the problem, students with spatial orientation type difficulties in understanding objects that experience changes in the position of objects experiencing rotation and difficulty in estimating the distance between two objects. Whereas students of spatial visualization type have difficulty in understanding the problem of connecting two separate objects into a single unit; (2) In devising a plan, students with spatial orientation type difficulties in determining concepts that can be used in problem solving planning conducted, while students with spatial ability types of spatial relations and spatial visualization have no difficulty in planning problem solving; (3) In the implementation of problem solving, both students with spatial ability types of spatial relations, spatial orientation and spatial visualization have difficulties in calculation algorithms and (4) In looking back steps, both students who have the type of spatial relations, spatial orientation and spatial visualization believes that the problem solving is correct so there is no need to looking back the problem solving.
 Keywords: student difficulties, problem solving, mathematical literacy, spatial ability


Abstract: Journalism is fully knitted into the web of information that exists in the world today. It links to it; sifts and filters it; collaborates with it and generally uses the ability of anyone to publish and share material to give a better account of the world. Rather than considering open journalism a mode of journalism or as a type of journalism, we consider open journalism a system, or a form of the organization including different forms of journalism that are often produced by a third party.


A process for making a structural ceramic article, such as, an electromagnetic window, is disclosed, wherein the ceramic article is comprised of a densified mixture of not less than 50% by volume aluminum nitride and up to about 50% by volume boron nitride. The ceramic article of the present invention may be used as a shield or protective barrier such as an electromagnetic win dow for communication or detection devices on high speed transportation or delivery vehicles passing through extremely hostile environments, where it ex hibits radar transparency, congruent vaporization kinet ics, tailorable dielectric properties, improved thermal shock resistance, improved mechanical toughness and strength, improved spall resistance, improved recession rate, i.e. erosion rate and ablation rate, and high refrac toriness.


Abstract Single crystals of InP with ⟨123⟩ orientation have been deformed at constant strain rates at temperatures between 540 and 780°C. The resulting stress–strain curves are rather similar to those obtained for other semiconductors such as Ge, Si and InSb, and two stages of dynamical recovery can be clearly identified. From the strain-rate and temperature dependences of the stress τiii at the beginning of the first recovery stage, an activation energy of 2.3 eV is deduced. This may be regarded as a lower bound for the activation energy of self-diffusion of the slowest-moving species; for the pre-exponential factor D0 of the diffusion coefficient a value between 10−3 and 10−2 cm2 s−1 is estimated.


This invention relates to a photoelectric detector use in 650nm fiber communication compose of four layers of heavy doped p+ surface layer/P layer/light doped N- epitaxial layer/heavy doped N+ substrate in following steps: growing a material, oxidizing, photo etching the oxide film, diffusing the P type, evaporating the photo etched Al, forming an electrode with alloy, evaporating the O photo etched anti-reflection film and evaporating the back electrodes with good property of 1-v, small dark current and high light response. The heavy doped p+ surface layer is thin to reduce the 'dead layer' thickness and enables most part of incident light to pass through the p+ layer and inject into P layer and one layer to generate effective photo-generated carriers to improve the performance of the emitting region and increase the short wave quantum efficiency.


Cosmologists might have discovered the source of a mysterious cold spot in the cosmic microwave background (CMB): an enormous supervoid in the universe's web of galxies.


Disclosed herein are novel compositions and methods for controlled release of bile acid scavengers to the stomach for treating or preventing upper gastrointestinal or throat disorders. The method generally includes administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid scavenger dispersed in a polymer matrix. A bile acid scavenger composition may be used alone or in combination with at least one proton pump inhibitor and optionally a antacid, a histamine H2 receptor antagonist, a γ-aminobutyric acid-β (GABA-B) agonist, a GABA-B agonist pro It can be administered in combination with one or more agents selected from drugs, acid pump antagonists, protease inhibitors, and GC-C agonists.


PREPARATION PROCESS alkadienes. ON MET IN CONTACT THE Butadiene Isoprene OR AT LEAST ONE CHOSEN CATALYST IN THE GROUP WITH PLATINUM AND PALLADIUM AND BASE METAL COMPOUNDS IN SOLUTION sULFOLANE IN THE PRESENCE OF FORMAT OF LOWER ALKYL TERTIARY AMINE AND AT LEAST ONE COMPOUND OF FORMULA I PHOSPHINE GENERAL: (CF DRAWING IN BOPI) IN AMOUNTS OF 4 TO 200MOLES BY aTOM-gRAM METAL FORMING THE CATALYST TO FORM alkadienes dIMERS, ON SEPARATE THE rEACTION IN MIDDLE LAYER AND CONTAINING alkadienes LAYER CONTAINING THE CATALYST AND ON RECYCLED LAYER CONTAINING THE CATALYST FOR THE PREPARATION PROCESS alkadienes.


Long non-coding RNA (lncRNA) are known to have various physiological and pathological functions. Some lncRNAs also show differential expression between cancer and normal tissues and play important roles in cancer development. In this study, we tried to identify novel lncRNAs that regulate epithelial-mesenchymal transition (EMT), invasion, tumorigenesis, and metastasis of lung cancer cells. We performed an NGS-based RNA sequencing analysis in murine lung cancer cells overexpressing ZEB1, an EMT-inducing transcription factor. ZEB1 overexpression changed the expression of total 194 lncRNAs: increased 80 and decreased 114 lncRNAs (fold change≥2, p≤0.01). We then selected 32 lncRNAs with high basal levels and confirmed their differential expression by qRT-PCR. In addition, we measured their expression changes after ZEB1-knockout in mesenchymal-like cells, TGFβ-treatment in epithelial-like cells, and ZEB1-overexpression in human lung cancer cells. Through these experiments, we found several lncRNAs regulated by ZEB1 or EMT in lung cancer cells. Expressions of these lncRNAs showed correlation with that of ZEB1 in human lung adenocarcinoma TCGA data. Further investigation will unveil the effects of these lncRNAs on EMT, cancer development, and metastasis of lung cancer cells. Citation Format: Jeong Seon Kim, Young-Ho Ahn. Identification of long noncoding RNAs regulated by ZEB1 and epithelial-mesenchymal transition in lung cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2470.


ABSTRACT This paper offers a tri-fold contribution. The original intent for this special issue paper was an investigation into outdoor recreational experiences that place 'nature' at the forefront of the activity, including Shinrin-Yoku (Forest Bathing); Friluftsliv; Uitwaaien; Gökotta; and Green-Care Farming. These nature-first approaches exemplify 'slow' leisure, offering a counter-narrative to highly structured and overly-engineered outdoor experiences. As the writing unfolded and with the passage of time, the World suddenly came to its own 'slowing' down – almost to a halt – as the Coronavirus (COVID-19) and the resurgence of the Black Lives Matter movement gained Worldwide prominence. As a result, the final version of this paper offers autoethnographic and theoretical insights into 'slow leisure' relevant to some of the challenges imposed by COVID-19 and societal (in)justices. This exploration advances an ideology of hope as life continues to shift, evolve, and reveal emergent potential(s).


The existence of multiple positive periodic solutions for a predator-prey system with Holling functional response for predator and Smith growth for prey is studied.Two bounded open sets are obtained by using analytic technique.By means of the continuation theorem based on coincidence degree theory,a set of sufficient conditions for this system to have at least two positive periodic solutions is obtained.Some known results are improved.


The field of tissue engineering has the potential to improve the quality of life of individuals through combining the knowledge of engineering and life sciences in creating engineered biological substitutes that repair, support and enhance tissue function.

Inkjet printing is a versatile tool that can be used for a broad range of applications. Ubiquitous in households, offices and industry, there has been growing interest in the use of inkjet printing for biological applications. Inkjet printing allows the user to deposit nano-picolitre volume of inks of low viscosity with high precision and high repeatability. Within this thesis, inkjet printing was used to explore its applications in the life sciences, with jetting behaviour and scaffold design optimised.

The creation of cell-friendly scaffolds was investigated. Gelatin scaffolds, crosslinked with inkjet printed glutaraldehyde were fabricated. Fibroblasts were seeded onto these fabricated scaffolds and shown to proliferate without hindrance, allowing a method to create sub-millimetre cell-friendly fibres for tissue engineering applications.

The ability for inkjet printing to create scaffolds to control cell alignment was investigated. Cell orientation can be controlled through inkjet printing paraffin wax to restrict cell proliferation on a substrate. Paraffin wax is not harmful or toxic to cells, and cells were able to grow within the negative spaces between the wax patterns, to create aligned cell culture as cells proliferated. An advantage with the wax scaffolds was that the wax scaffold was readily removable with a scalpel that allowed further analysis of cell behaviour when proliferating into an unrestricted space. A proportion of cells was also detached upon wax removal, proportional to cell density within the wax scaffold and wax channel width. After wax removal, cell cultures quickly lost their ordered appearance within 3 days as they proliferated randomly across the substrate.

The creation of in vitro vasculature models through the use of a combination of inkjet-printed wax, PDMS moulding and wax-loss method to create medical phantoms for the study of rheological behaviour was studied. The scalloping behaviour of the printed wax vessel was reduced in the final phantom created, as there would be a thin lining of wax that covers the interior of the PDMS mould after wax removal, making the vessel smoother.
Cell printing of neuronally relevant cells were investigated. NG108-15 and porcine Schwann cells (along with fibroblasts to act as a control experiment) were inkjet printed, studying cell viability during and after inkjet printing. It was concluded that cells were not significantly damaged during inkjet printing over a wide range of voltages (50 V-230 V), and no correlation was seen to show an increase in cell death with increasing voltages. Inkjet printed NG108-15 cells showed they produced longer neurites compared to control samples after 7 days. Further to results, it was confirmed that cell printing is limited to a duration of less than 40 minutes due to cell aggregation within the reservoir of the printing system, causing a steady significant decrease in cell numbers during printing.


A catalyst for the thinking in this paper is the way in which the concentrated direct audition of materials central to the process of electroacoustic composition can, in conjunction with powerful tools for the deconstruction and synthesis of sounds, influence the nature of musical relationships that are formed.


Provided are a socket for a hip disarticulation prosthesis and a hip disarticulation prosthesis that can be attached by even patients with functional disorder in both lower legs, that control deterioration of wound and injury sites, and that allow training in standing and walking. The seated position-type hip disarticulation prosthesis is configured by using, in a hip disarticulation prosthesis that replaces all lower extremities below the hip joint, a socket 10 with a configuration that comprises a seat portion 2 that holds the pelvis of the wearer from below and a pelvis holding portion 1 that is integrally formed with the seat portion 2 and that holds the pelvis of the wearer from the rear and the sides. The hip joint, the thigh support, the knee joint, the lower leg support, the ankle joint, the foot portion, and the like are linked to the bottom face of the seat portion 2 of the socket 10. The seated position-type hip disarticulation prosthesis is attached from a seated position and used in the seated state.


OLIVEIRA, Priscila Soares de. Morphology of the visual system of the five species of the genus Megalopta and the relationship with the environment which they live 2019. 75f. Dissertação (Mestrado em CiênciasÁrea de Concentração Entomologia) – Faculdade de Filosofia, Ciências e Letras, Universidade de São Paulo, Ribeirão Preto, 2019. Bees are typically diurnal, but there are also some nocturnal or crepuscular species that fly and feed before dawn or after sunset. These bees include two groups: crepuscular and truly nocturnal. The objective of this work was to verify the morphological differences in the visual system of five species of bees of the genus Megalopta that live in areas with closed and open vegetation, more specifically of the Rain Forest, Atlantic Forest and Brazilian Savanna. For this, dried bees collected in other projects were used. Five species of Megalopta were used. M. aegis, M. aeneicollis, M. amoena, M. guimaraesi and M. sodalis. The measurements of head, eyes, ocelli and omattidia were made using traditional and geometric morphometry techniques. These techniques pointed out differences among species, placing M. sodalis as the species with the highest measurements of head, eye and ocelli. However, for the omatídeos, the species with the highest amount is M. aeneicollis, however, the species with the largest omatídeos perimeter is M. sodalis, which has a smaller quantity. The work hypothesis could be partially confirmed, because M. sodalis is a typical forest species, an environment with low luminosity due to the dense and closed forest, requiring compound eyes and larger omattidia.


This article discusses the aspects of the IT technologies application in the educational sphere. The implementation of the IT project in the education, as in any other sphere of activity, is a complex scienceintensive process that requires the certain time costs for implementation. In solving the problems of the duration estimating of the new IT projects under uncertainty, there is often a need to use the methods of statistical data analysis. Therefore, we propose to use the hybrid intelligent classification technology to the duration assessment of the new IT projects based on the hybridization of the SVM algorithm with the intelligent classification algorithms such as the random forest algorithm and the k nearest neighbor algorithm. The hybridization of the SVM classifier with the intelligent classification algorithms allows to obtain the sufficiently high values of the classification quality indicators with the less time expenditures than in the alternative approaches to application of the SVM classifier based on the search of its parameters values using, for example, the grid search algorithms or the evolutionary algorithms. The offered hybrid intelligent classification technology was tested using the different datasets and can be recommended for classification of the new objects, in particular, to predict the implementation duration of the new IT projects in the educational sphere. The enlarged scheme of the process of developing of the intelligent data analysis system and predicting of the new projects duration has been presented. © 2018 Published by Future Academy www.FutureAcademy.org.UK


The present works deals with the presentation and test of a novel Power Quality index, based in Higher-Order cumulants. Synthetics are used for test different start point, amplitude and length for the most common Power Grid disturbances (DIP, Oscillatory Transient, Harmonic Temporal Distortion and Impulsive Transient), obtaining a high accuracy (over 99% in some disturbances). Then real signals are used for confirm synthetics results. Finally, the Power Quality index presented, is confirmed with real signals as a good tool for detect imperfections in the power waveform.


This invention discloses an entropy-coding control method and an entropy coding circuit, which generates a process result at each logic functional unit and provides it to its adjacent latter logic functional unit when the logic process in the adjacent latter logic functional unit is finished so as to avoid jam of pipelines and error entropy coding at the time when realizing pipeline way and increase process efficiency.


This article presents a comparative analysis of forms of interaction between real and financial sectors of the economy in different clusters in the regional economy. Significant differences between the nature of the interaction of real and financial sector, depending on the direction of the regional cluster is its orientation to the internal or external customer, as well as the nature of competition and pricing for the products. DOI: 10.5901/mjss.2015.v6n1s3p256


Context: Access to education is a fundamental right that should be realised to the degree that every child can develop their talents to the fullest potential. Therefore, children with special education needs and disabilities (SEND) have the right to claim resources and aid to function in schools and should not be excluded from any level of mainstream education. However, the process towards executing this fundamental right is slowed down by existing ableist structures.
Policy Options: This policy brief analyses inclusive education policies from the perspective of four different European Countries (Italy, the Netherlands, Poland, and the United Kingdom). The data was synthesised using four types of ableism that are addressed in this policy brief. The gaps within definitions and argumentation were identified and discussed to provide recommendations concerning education for people with SEND.
Recommendations: The evaluation provided three significant recommendations towards inclusive education systems by addressing ableist structures. Firstly, it is crucial to reduce the linguistic gaps between national educational policies and the underlying national laws. Secondly, it is necessary to include the target group and raise awareness for SEND to reinforce societal and scientific perspectives, and influence policy decision-making. Lastly, it is important to address the discrepancies between the inclusive education policies and the structural capacity. The synergy between these two key factors is crucial for an effective implementation of inclusive education.


This paper takes a new approach to examine whether investors extrapolate from past returns to form expectations about future stock returns. Unlike prior research that relies on experiments or surveys to derive investors' expectations, we estimate expected returns directly from stock prices, the book value of equity, and analyst earnings forecasts. We find that the expected returns are positively related to both past market returns and past stock returns. However, investors' expectations seem to be overoptimistic (overpessimistic) for stocks that had extremely high (low) returns in the previous year. Furthermore, we find that investors' expectations about future earnings growth rates are also positively related to past growth rates. The results remain robust after we control for analyst optimism and measures of risk. Taken together, our results are consistent with the findings that investors extrapolate from past stock returns and past earnings growth rates.


This article explores the production, in particular innovation, of Plered ceramics. Innovation development seeks to recognize innovations and improvements, as well as the role of institutions in the ceramic industry at Plered. The analysis approach used is qualitative, through observation, interviews, literature review data sources are collected.The results showed that the development of Plered ceramics was carried out in terms of product and process. Product innovation occurs in aspects of type, form and function, while process innovation occurs in aspects of ideas, materials and production techniques. The roles of government, academics, entrepreneurs and consumers who work together are very supportive of the development of Plered ceramics.


[Objective] To explore the effect of δ-aminolevulinate acid dehydratase( ALAD)gene polymorphism on hormone levels of thyroid in workers occupationally exposed to lead.[ Methods] 171 occupationally lead exposed workers in a storage battery factory were investigated. Thyroid hormones were detected by radioimmunoassay( RIA), including triiodothyronine( T3), free triiodothyronine( FT3), thyroxin( T4), free thyroxin( FT4) and thyroid-stimulating hormone( TSH). Polymorphism genotype of ALAD gene was determined by PCR-RFLP technique with the restriction enzyme Msp Ⅰ . The relationship between thyroid hormone levels and ALAD polymorphism was analyzed. [ Results] Among these 171 workers, there are 156 ALAD1-1 homozygotes (91.23%), 15 ALAD1-2 heterozygotes( 8.77%) and no ALAD2-2 homozygotes. The frequencies of ALAD1 and ALAD2 alleles are 95.61% and 4.39%. The PbB level of ALAD1-2 heterozygotes is1.06(0.87~1.24)μmol/L,which is significantly higher than that of ALAD1-1 homozygotes 0.77(0.72~0.83) μmol/L( F=8.14, P 0.05), analyzed by analysis of covariance. Thyroid hormone levels of high PbB group( PbB≥0.97 μmol/L ) are compared with those of low PbB group( PbB 0 .97 μmol/L), the results showed that T3,FT3,T4 and TSH depressed, FT4 elevated a little. The levels of T3,FT3 and TSH of ALAD1-2 subgroup are lower than those of ALAD1-1 subgroup, but there is no difference of T4 and FT4 in these two subgroups. In the two PbB subgroups, the levels of T3,FT3 and TSH of ALAD1-2 heterozygotes are both lower than that of ALAD1-1 homozygotes, but the levels of T4 and FT4 have no difference.[ Conclusions] ALAD2 allele could increase occupationally lead-exposed workers' blood lead level and lead body burden. In the same occupational workplace and blood lead levels, ALAD2 allele might aggravate lead toxicity on thyroidhormones, which needs to be confirmed in coming study with larger sample sizes.


Because of their special characteristics, minors should have more interests than the intrinsic social interests, and more weight should be placed in the criminal legislation and judicature on protecting the minors' interests. This protecting conception embodies the value of criminal law, such as justices, order, freedom and efficiency.


cal analysis to document how contemporary consumers, as experienced viewers of romantic intimacy in film and advertising, construct and discuss their love lives according to popular stereotypes. Gender differences are barely discussed, but interviews with 50 men and women reveal some interesting commonalities and differences across class lines. By asking her respondents to comment on their own romantic encounters, to answer questions about relationship vignettes, to evaluate photographs (plates reproduced in an appendix), and to judge greeting cards, Illouz shows how popular culture shapes personal narratives and helps construct romantic selves. Some might challenge Illouz's suggestion that "the upper middle class is better equipped to cope with the cultural contradictions . . . of love" (p. 285) or reject the claim that gender differences are minimized in contemporary commercial imagery, but she has presented a forceful and compelling case that romance has become commodified and commodities have become romanticized. I would recommend this well-written book to any serious scholar interested in the sociology of love and will add it to the reading list for my graduate students specializing in cultural studies.


The objective of this work is to describe and analyze the advances in knowledge concerning lipid oxidation reactions in food and biological systems and their implications in the quality of food, nutrition and health. Thus, mechanisms, factors and conditions associated with these reactions are analyzed in food and human body. So, problems like deterioration of color, texture and sensory characteristics of food are evaluated. Nutritional problems caused by chronic ingestion of oxidized food and its physiopathological consequences are also discussed. Furthermore, several pathological states like atherosclerosis, cancer, diabetes, psychological stress, infections (HIV), drug intoxications, nutritional deficiencies and other processes involving formation of oxygen free radicals are related. Finally, the Brazilian population perspectives and the strategies of intervention for effective prevention of these problems are discussed.


Objective:To study the effect of traditional Chinese medicine on the immunologic function and ultrastructural change of liver cells in preventing and treating liver fibrosis.Methods:The mouse model of liver fibrosis was established,the pathohistology and ultrastruc- ture of liver cells was observed,and the dynamic determination of the 2′,5′-oligoadenylate synthetase activity (OASA) was carried out. Results:In the model group,widespread fatty degeneration in liver cells,large amount of collagenous fiber was found in the portal area, and OASA lowered in comparing with the normal group.In Ershen Zezhu decoction(ESZZ) prevention group,the liver ultrastructure was normal,and no collagenous fiber was found in the liver tissue.And in the ESZZ treatment group,only small amount of collagenous fiber among the liver cells was seen.The OASA in the prevention and treatment group of ESZZ increased obviously compared with that of the model group (prevention group P0.01,treatment group P0.01).However,in the prevention and treatment group of Dan- shen Taoxiong decoction(DSTX),the degeneration and necrosis of liver cells were severe,the collagenous fiber proliferated markedly, and the OASA reduced.The results revealed that the pathologic changes of the liver tissue was consistent with the changes of immuno- logic function in experiment group.Conclusion:ESZZ was better than DSTX in enhancing the immunologic function of liver fibrosis in mice and in preventing and treating liver fibrosis.Experimental study showed that the immunological function is closely related with the therapeutical effect during the treatment of liver fibrosis,and the determination of OASA could reflect the prognosis of liver fibrosis, which is important clinically.


Phytoestrogens containing isoflavonoids are thought to exhibit preventative effects on estrogen-responsive diseases. Chemical modifications, such as prenylation, in biosynthetic processes enhance the structural variety of isoflavonoids and prompted us to carry out a structure-activity relationship study. We determined the estrogenic/anti-estrogenic activities and estrogen receptor (ER)-binding affinities of eight kinds of prenylated isoflavones isolated from Millettia pachycarpa (Leguminosae), and those of two kinds of non-prenylated compounds (genistein and daidzein). By comparing these compounds, the pharmacophores for estrogenic/anti-estrogenic activities were elucidated. None of the tested compounds (except genistein) were estrogenic on ligand-dependent yeast-two hybrid assay. On the other hand, 5 isoflavones showed distinct anti-estrogenic activity. Unexpectedly, the most potent antagonists, isoerysenegalensein E and 6,8-diprenylorobol, showed anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical ER antagonist. This suggests that genistein became an antagonist after prenylation and hydroxylation. The pharmacophores providing genistein with strong anti-estrogenic activity were as follows: prenyl groups of the 6- and 8-positions on the A-ring, hydroxyl group of the 6-prenyl moiety or the B-ring (catechol form), non-cyclization of the prenyl group with the A-ring, and non-hydroxylation of the 8-prenyl group on the A-ring. The ER-binding affinities of the isoflavonoids were not sufficiently high to explain their potent antagonistic activities, thus suggesting 17β-estradiol-non-competitive mechanisms.


Abstract : BER measurements at 2.5 Gbit/s on wavelength converted signals using double pump FWM in a semiconductor optical amplifier have been performed experimentally for both single- and multiple-input wavelengths. These results were presented at an OSA sponsored conference entitled: Advanced Semiconductor Lasers and their applications" and the results have appeared in print in Trends in Optics and Photonics.


This work was to develop a switch control approach for operating constrained mechanisms such as screwing valves or opening doors by using a rescuing mobile manipulator. The main concern is the prevention of generation of large internal forces attributed to location errors or imprecise parameter identification. Unlike conventional active or passive control methods, the proposed concept employs the switch control strategy to guarantee switching of robot joints in different working modes. Each joint of the rescuing mobile manipulator is designed with multiple working modes (passive mode and active mode). Active and passive control laws are provided for different working modes. The switch controller is realized to work the joints in the passive mode or active model automatically based on the analysis of Lyapunov stability. Thus, the stable operation is achieved with smaller inside force. From the analysis of system simulation and test results, the explanation of the effectiveness was definitely.


Cervical cancer is a serious public health problem. In Brazil, it is the third most common cancer among women and the fourth leading cause of death, even though it has a high cure potential when identified early. Objective: To highlight the sociodemographic and clinical profile of women affected by cervical cancer in Brazil. Method: this is an integrative literature review study, carried out in the databases of the Scientific Electronic Library Online (SCIELO), Medical Literature Analysis and Retrieval System Online (MEDLINE) and National Library of Medicine (PUBMED), in the period included between 2015 to 2020. Results. The findings showed that women with difficulty in accessing health care are the most affected by cervical cancer, as well as those at older ages, however it also affects young women. It was also evidenced that the low level of education, women of the black and indigenous races and the low socioeconomic situation are frequent among those affected by the disease. As for the clinical profile, most of them were diagnosed in advanced stages of the pathology, demonstrating the reality of the late diagnosis of the disease and the fragility of the health system for prevention and early diagnosis. Conclusion: The results point to the need to implement new strategies aimed at primary and secondary prevention of the disease, in view of the large number of diagnosed women. Greater investments in education are also necessary in order to change the morbidity and mortality profile of the pathology.


Fuel oil and lubricating oil costs are compared with the other running costs of large ships and are shown to be a substantial fraction of the total. The various drag forces exerted on a ship are compared and the individual properties which influence most of the major drag force, friction, are identified. A number of techniques for reducing friction forces are considered, some proving practical and some the reverse. The effect on oil consumption and costs of one technique in particular, that is the removal of water from the bottom of the ship by means of a compressed air cavity, are considered. /AUTHOR/


While in general there is no one-to-one correspondence between complex and quaternion quantum mechanics (QQM), there exists at least one version of QQM in which a partial set of translations may be made. We define these translations and use the rules to obtain rapid quaternion counterparts (some of which are new) of standard quantum mechanical results.


Gene-expression analysis is increasingly important in biological research, with real-time reverse PCR (RTPCR) becoming the method of choice for high-throughput and accurate expression profiling of selected genes. However, this technique requires important preliminary work for standardizing and optimizing the many parameters involved in the analysis. Plant stress studies are more and more based on gene expression. The analysis of gene expression requires sensitive and reproducible measurements for specific mRNA sequence. Several genes are regulated in response to abitoic stresses, such as salinity, and their gene products function in stress response and tolerance. The design of the primers and TaqMan probes for real-time PCR assays were carried out using the Primer ExpressTM software 3.0. The PCR efficiency was estimated through the linear regression of the dilution curve. To understand the expression pattern of various genes under salt stressed condition, we have developed a unique public resource of 9 stress-related genes in poplar. In this study, real-time RT-PCR was used to quantify the transcript level of 10 genes (9 stress-related genes and 1 house keeping gene) that could play a role in adaptation of Populus davidiana. Real-time RT-PCR analyses exhibited different expression ratios of related genes. The data obtained showed that determination of mRNA levels could constitute a new approach to study the stress response of P. davidiana after adaptation during growth in salinity condition.


Skin infections are a common cause of morbidity in children, particularly in tropical areas. Cultures from such lesions often grow both penicillin‐resistant staphylococci and penicillin‐sensitive streptococci. In a controlled trial of the treatment of septic skin lesions in 227 paediatric outpatients at Goroka Hospital, sequential analysis of the response to treatment showed that washing plus the intramuscular administration of procaine penicillin was more effective than washing plus placebo (P < 0.05) after the 25th preference had been decided. When the amount of healing in the two groups was compared, washing plus penicillin was again more effective than washing plus placebo (P < 0.001; Wilcoxon's rank‐sum test). Because it eradicates β‐haemolytic streptococci, penicillin is a safe and effective agent for the treatment of large, multiple, or badly infected skin sores, even in countries such as Australia and Papua New Guinea in which most staphylococci are resistant to penicillin.


We study dynamics of employment and wages in labor markets where assignment plays an important role. We document new facts about inter and intra sector mobility in one example of such a market: the market for PhDs in both academia and the private sector. When the outside option (private sector wage) is higher, the exit rate from academia is higher, and, more strikingly, the rate of job mobility within academia is also higher. These dynamics are primarily driven by the relatively inexperienced and are more pronounced when the ratio of PhDs to academic jobs is higher. We develop a dynamic model of assignment and sectoral choice to explain these facts and explore how policies such as wage compression, tenure, and golden parachutes affect the equilibrium distribution of wages, lifecycle job mobility, and the extent of misallocation between workers and jobs. ∗All mistakes are our own. Any and all comments welcome. Preliminary please do not circulate without permission. †Princeton University and NBER. E-mail: email@example.com ‡University of Houston. E-mail: firstname.lastname@example.com


The aim of this research is to prove that eco-efficiency has an effect on firm value and the funding structure has a strong influence on eco-efficiency on firm value. This study includes quantitative research because it uses secondary data and manufacturing companies listed on the Indonesia Stock Exchange from 2015 to 2019 are the samples selected in this study. Multiple linear regression analysis technique was used in this study. The result of the analysis is that eco-efficiency has a significant negative effect on firm value. This is an indication that companies that implement eco-efficiency implementation will reduce firm value. While the results of the analysis on the funding structure have a significant positive effect giving a strong impact on eco-efficiency on firm value. The results indicate that the company's management must plan its obligations in preparing the funding structure for managing the use of natural resources efficiently in order to avoid contingency problems that will arise. The eco-efficiency concept makes it easier for companies to create products with added value and can help companies reduce the risk of the production process.


Isospin relations are used to eliminate hadronic uncertainties in various {ital CP} asymmetries in {ital B}{sup 0} decays via {ital b}{r arrow}{ital u{bar u}s}, e.g., {ital B}{sup 0}{r arrow}{pi}{sup 0}{ital K}{sub {ital S}}. A clean measurement of the angle {alpha} of the unitarity triangle is thus made possible. The magnitudes of the tree and the penguin amplitudes can be measured.


The health system in the United States has evolved into a crazy quilt of multiple providers and payers striving to care for complex patients, who experience transitions across multiple settings. Case management is being used to address patient problems that result from system fragmentation and complexity. Case management for patients is highly contextual and is often designed to meet the needs of patients who have specific types of illnesses such as congestive heart failure, disabilities such as spinal cord injuries, mental health problems, substance abuse, and mental retardation developmental disabilities, or who are receiving care in a particular setting, such as acute care, community care, or rehabilitation. The article by Park, Huber, and Tahan in this issue begins to unravel some of the contextual factors of case management by exploring case management activities by knowledge areas, work setting, and profession. They find that there is a pattern to the type of work undertaken by case managers by discipline and work setting. They are able to identify a set of core activities that crosses disciplines and settings. They also identify important differences in case management activities by discipline and setting. Although Park et al. add a substantial contribution to the description of case management practice, there remains many perplexing problems associated with the design of case management research. Perhaps one of the most problematic issues is the plethora of related terms, such as care management, care coordination, and case management, that are used to describe very similar activities that revolve around organizing care and ensuring care continuity. One of the most cogent problems in designing case management research is determining the difference between these terms. What is care management, and is it a part of case management? Is case management the same as care coordination? Does care coordination fall under the umbrella of case management? Perhaps these are all just the same thing but are called something different depending on which setting or population the investigator is studying.


An adaptive level set method is implemented to solve the quasi-steady state approximation of the Stefan problem. The grid adaptivity is based on a minimization of the Winslow functional with a monitor function coupled with the level set function. Temperature field is computed by applying techniques from Ghost-Fluid Method [17, 5] to the Laplace equation in the transformed coordinate system. By extending this temperature using fast-sweeping method [21, 8, 9], the normal velocity of the interface is obtained and is used to update the level set function. Several numerical examples will also be included to demonstrate the computational efficiency of the resulting algorithm.


Genome and DNA Sequence Analysis Genome Analysis Genome structure analysis by genome browser Sequence similarity searching by BLAST Two Common DNA Analysis Tools Restriction mapping PCR application Phylogenetics Analysis Multiple sequence alignments Building phylogenetics tree SNP and Haplotype Analysis SNP analysis Haplotype analysis Transcriptome and RNA Sequence Analysis Gene Expression Profiling by Microarray Experimental design Data acquisition and preprocessing Data analysis Tutorial Gene Expression Profiling by SAGE SAGE experimentation SAGE data analysis Retrieve data from SAGE database Regulation of Gene Expression Alternative promoters Alternatively splicing Alternative translation initiation RNA editing MicroRNoma Genome-Wide Profiling by Microarray What are miRNAs? microRNAs and human diseases Significance of microRNA profiling Significance of microRNA CGH assay Genome-wide microRNA profiling by microarray RNAi Introduction of RNAi and siRNA Search for siRNA information Proteome and Protein Sequence Analysis Proteome Analysis Analyzing 2DE-derived data Analyzing mass spectrometry derived data Analyzing data derived from protein microarrays Protein Sequence Analysis Primary structure analysis Secondary and tertiary structure analysis Pattern and profile search Protein Function Analysis Protein function annotation Protein posttranslational modifications Protein-protein interactions Functional Annotation of Proteins in Murine Models Various murine models of human diseases Search for murine databases Basic Biocomputing Tools Application of Programming Languages in Biology Application of Perl in biology Application of R in biology Website and Database Design Personal website design Nuts and bolts of biological databases and their constructions Microsoft Excel and Access Microsoft Excel Microsoft Access Interchange data between Microsoft Excel and Access Appendices Abbreviations Selected glossary Websites for selected bioinformatics softwares Index


As a basic instrument for electronic signal measurement, digital storage oscilloscope (DSO) is widely used in many occasions. Signal condition circuit, which is an important part for vertical system in DSO, is often realized by discrete components such as comparator, operation amplifier (OPA), digital-to-analog convertor (DAC) etc. However the component characteristics cannot be identical in different oscilloscopes. Besides, aging and temperature can lead to the change of component parameter. In both of these situations, vertical and trigger system in DSO will have extra error. Therefore, self-calibration function is provided in most DSO. In this paper, a fast and high accuracy self-calibration algorithm based on an improved success-failure method is proposed for calibrating the baseline and trigger level. The calibration can be implemented without reference signal. This method is also implemented in a DSO. The calibration result shows the efficiency of proposed method.


Thee present study focus on examining the denominative variation phenomenon in fauna and ora terminology in Portuguese, English, Italian and Spanish languages.Assuming that the proximity of the observer to the species natural habitat facilitates the formation of both the scientific and vernacular names, we analyse the denominative variants in Portuguese of about two hundred species, comparing the motivation of such items in this language, as well as in Spanish, Italian and English.We based our search on Communicative Theory of Terminology and we affrm that cultural, social and historic factors contribute to the composition of terminology under consideration, with emphasis on denominative variants composed by colour names, i.e., the specialized chromatic phrases.


Image contrast enhancement is aim to enhance the contrast level of images, which are degraded during acquisition process. In this paper the contrast enhancement of image has been taken as an optimization problem and artificial bee colony (ABC) algorithm has been used here to solve the optimization problem. The work has been done in two phase, in the 1st phase a fitness function has been proposed to evaluate the quality of the enhanced image where as in the 2nd phase is to generate new pixel intensities for the enhanced image from the original input image. Artificial bee colony technique is used to optimized the searching parameter. Experimental analysis has been drawn and the result has been presented to support the proposed method.


BACKGROUND AND PURPOSE PA‐824 is a 2‐nitroimidazooxazine prodrug currently in Phase II clinical trial for tuberculosis therapy. It is bioactivated by a deazaflavin (F420)‐dependent nitroreductase (Ddn) isolated from Mycobacterium tuberculosis to form a des‐nitro metabolite. This releases toxic reactive nitrogen species which may be responsible for its anti‐mycobacterial activity. There are no published reports of mammalian enzymes bioactivating this prodrug. We have investigated the metabolism of PA‐824 following incubation with a subcellular fraction of human liver, in comparison with purified Ddn, M. tuberculosis and Mycobacterium smegmatis.


In this paper the induced charge distribution on a spherical petroleum tank due to lightning is calcuated with analytical method,and that on a cylindrical petroleum tank is calculated with charge simulation method (CSM).Furthermore,the protecting behavior of the lightning rod on the cylidrical tank is calculated and tested respectively.


Subcutaneous fat necrosis (SCFN) is a form of panniculitis classically affecting healthy full-term infant during the first month of life [1,2]. The lesions usually develop after a free interval on the cheeks, buttocks, trunk and limbs [3]. The evolution is generally benign although it can be associated with severe hypercalcemia, leading to possibly life-threatening complications [4-6]. Here we present a rare case of congenital subcutaneous fat necrosis and a literature review regarding the clinical features, diagnostic and therapeutic aspects and prognosis of this rare entity.


This paper revisits the relationship between Maxwell's Electromagnetic Theory (EMT) and coordinate transformations that can be implemented via tensors. It is well known that under Lorentz transformation, Maxwell's equations are form-invariant (although of course not invariant in numerical values, except for a few one-dimensional constructs). That fact means Maxwell's EMT fits well with Einstein's Special Relativity Theory (SRT). This paper shows that the situation is almost the same under Galilean transformations, and possibly other plausible transformations that may be considered in the future. The only difference is that some constructs that are number-invariant under Lorentz transformation become only form-invariant under Galilean transformation. Thus the issue of form invariance for Maxwell's equations is not a strong indicator in favor of any particular kind of coordinate transformation. That fact means Maxwell's EMT fits well with just about any reasonable variant of SRT.


The growing public awareness of environmental issues has placed considerable demands on railway authorities to reduce any excessive noise levels associated with the operations of the rolling stock. The current study, which has been conducted in the Hunter Valley Region of the Rail Infrastructure Corporation, has examined two main causes of the considerable noise that can be generated by the wheel/rail interaction, namely: Flanging of the wheels on the rails that occurs in sharp radius curves. Wheel 'squeal', which can arise from the slip/stick action of wheel sets engaging sharp radius curves. The results obtained have shown that the appropriate application of lubricants and friction modifiers can lead to marked reductions in the wheel/rail noise levels. The work has also shown that the lateral wheel loads produced during curve negotiation are also reduced substantially by the application of friction modifiers to the running surface of the rails.


We exploit the analogy between the transfer of a pulse across a scattering medium and Aharonov's weak measurements to resolve the long standing paradox between the impossibility to exceed the speed of light and the seemingly 'superluminal' behaviour of a tunnelling particle in the barrier or a photon in a 'fast-light' medium. We demonstrate that 'superluminality'


Background: High and ultra-high dilutions of various starting materials, e.g. copper sulfate, Hypericum perforatum and sulfur, showed significant differences in ultraviolet light (UV) transmission from controls and amongst different dilution levels [1,2].
Verum and placebo globules of Aconitum napellus 30c or calcium carbonate/quercus e cortice 6x from the same packs as used in previous clinical trials and dissolved in water could be distinguished by UV spectroscopy [3]. However, it was unclear whether the differences in UV absorbance originated from specific characteristics of the starting materials, from differences in the production of verum and placebo globules, and/or other unknown interference factors.

Aims: The aim of this study was to investigate whether globules produced with high and ultra-high dilutions (6x, 12x, 30c, 200c, 200CF (centesimal discontinuous fluxion), 10,000CF) of various starting materials (Aconitum napellus, Atropa belladonna, phosphorus, sulfur, Apis mellifica, quartz) could be distinguished by UV spectroscopy.

Methodology: The globules were specially produced for this study by Spagyros AG (Gumligen, Switzerland) and differed only in the starting materials of the dilutions (but not in the batch of globules or ethanol used).
Globules were dissolved in water at 10 mg/ml, in quadruplicates, approximately 22 h prior to the measurements. Absorbance of the samples in the UV range (from 190 to 340 nm) was measured in a randomized order with a Shimadzu double beam UV-1800 spectrophotometer equipped with an auto sampler. Samples of each starting material were prepared and measured on 5 independent days. The daily variations of the spectrophotometer as well as the drift during the measurements were corrected for.
The average absorbance from 200 to 340 nm was compared among various starting materials within equal dilution levels using a Kruskal-Wallis test.
Results: Statistically significant differences were found among 30c (Figure 1), 200c and 200CF dilutions of the various starting materials. No differences were found among 6x, 12x and 10,000CF dilutions.

Conclusions: Globules prepared from high dilutions of various starting materials may show significantly different UV absorbance when dissolved in water.

References
[1] Wolf U, Wolf M, Heusser P, Thurneysen A, Baumgartner S. Homeopathic preparations of quartz, sulfur and copper sulfate assessed by UV-spectroscopy. Evid Based Complement Alternat Med. 2011;2011:692798.
[2] Klein SD, Sandig A, Baumgartner S, Wolf U. Differences in median ultraviolet light transmissions of serial homeopathic dilutions of copper sulfate, Hypericum perforatum, and sulfur. Evid Based Complement Alternat Med. 2013;2013:370609.
[3] Klein SD, Wolf U. Investigating homeopathic verum and placebo globules with ultraviolet spectroscopy. Forsch Komplementmed. 2013, accepted.


This paper examines performance of Fama-French five-factor model in US market before and after Covid-19 outbreak. The research purpose is to validate the efficiency of the model in the pandemic period, study if there're unexplained factors, and if Fama-French factors beta changes due to the pandemic impact. OLS method is applied to 49 Fama-French industry portfolios, and this paper finds that the efficiency of Fama-French five-factor model strengthened after the outbreak in all industries, while unexplained factor behavior increased. The pandemic brings significantly change to Fama-French factors beta of most of industries respectively, and has strong impact on portfolio performance and factor exposures.


In the 1980s, much attention centers on educational reform. The President of the United States started the ball rolling by appointing a special commission which subsequently proclaimed a national crisis. Since then, senators, governors, state legislators, and mayors have echoed the concern: something significant needs to be done to upgrade American education. Their concerns have spawned still more commissions, created a variety of policies and programs to improve schools, and renewed the vigilance of parents and local communities. Spurred on in large measure by the effective schools research, administrators and teachers have not been passive respondents to initiatives from outside. Their internal efforts to improve schools have often preceded or paralleled the call to action from federal, state, or local governing bodies. Taken in toto, the sheer amount of time, effort, and resources devoted to improving America's schools should reap an immediate payoff in new approaches or practices and ultimately yield greater performance dividends. However, those with long-term memories of prior efforts to change public schools are less optimistic. We can faintly recollect the attempts to alter high school staffing patterns and instruction in the 1950s. We can recall with nostalgia the educational innovations of the 1960s. We can remember, among others, the experiments with vouchers, individualized instruction, educational objectives, team teaching, and instructional technology in the 1970s. Across the memories a familiar scenario takes form: the basic shape of schools and the core of schooling remains intact once the whirlwind of activity subsides.


This paper presents an overview of rare earth-doped waveguide lasers in both glass and lithium niobate (LiNbO3). The historical development of these devices together with the most recent advances in the field are described.


In the UK there has been a move away from a paternalistic model of medicine. A clearer ethical framework has now evolved and it is accepted that four main ethical principles, such as autonomy, non-maleficence, beneficence and justice in medical practice. There is no distinction ethically between withholding and withdrawing a mode of therapy. When a therapy is not considered to offer any benefit there is no obligation to institute it. On the other hand, there is an obligation to maximise comfort and minimise pain or distress of patients even when the side effects may actually appear to precipitate the patient' s death (Principle of Double Effect) . The General Medical Council, the British Medical Association Ethics Committee, as well as the various Royal Colleges provide guidance on healthcare related ethical issues, but do not provide advice on individual cases. Although, ethics committees in UK hospitals are mainly Research Ethics Committees, but gradually appearing those support on clinical ethics throughout the UK. For the patients who lack the ability to give consent, the various treatment options are discussed with the family and treatment is permitted by legislation in Scotland (Adults with Incapacity Act 2000) . We describe specific aspects of end of life decisions in intensive care. Abstract was edited by Editorial Board.


Introduction: The Get With The Guidelines-Heart Failure (GWTG-HF) risk score predicts inpatient mortality in hospitalized patients with acute heart failure. The predictive utility of the GWTG-HF ri...


Objective To discuss the influence of earlier period colligation intervention to neonatal hypoxic-ischemic encephalopathy (HIE) prognosis. Methods Sixty-four cases of middle or serious HIE were divieded into intervention group (40 cases) and control group (24 cases). The method of intervention involved the education of seeing, hearing, rasing head and limbs activity from neonatal period,the eaducation of sensation audio,language,memory and activity during infancy, physiotherapy to cerebral palsy patients or suspected cerebral palsy patients ,hyperbaric oxygen-therapy as well as injecting cerebrolysin. Intervention was not done in the control group. All the cases received intellectual development follow-up and detection in the infants of 6,12 and 18 months old. Results The intellectual developed quotient of intervention group was higher than that of the control group at the same month age (P0. 05). While the sequela incidence of the intervention group was obvious lower than control group(x2 = 22. 02,P0. 01). Conclusion Giving earlier continuing intervention to middle or serious HIE can effectivly reduce the incidence of sequela.


Heat stress (HS) is becoming a major and constant threat to crop production and food security as global warming progresses. Consequently, understanding and improving crop tolerance to HS are currently among the most important targets in plant biology and breeding research (Langridge and Reynolds, 2021). Recent evidences suggest epigenetic mechanisms act as new layer of regulation to cope with HS (Ohama et al., 2017; Song et al., 2021). However, the specific regulatory module composed of epigenetic factor and transcription factor in establishing thermotolerance remains unclear. As a typical cool-season crop, wheat is vulnerable to HS, especially at the flowering and grainfilling stages (Kaur et al., 2019). Here, we report that TaHAG1 plays a pivotal role in thermotolerance by maintaining the photosynthetic stability in wheat. TaHAG1 encodes a histone acetyltransferase, orthologous with Arabidopsis AtHAG1/GCN5 and rice OsHAG702 (Zheng et al., 2021). There are three TaHAG1 homoeologs in hexaploid wheat, whose deduced proteins contain conserved N-terminal HAT domain and C-terminal bromodomain (Figure 1a). TaHAG1 localizes in the nucleus (Figure 1b). Transcript of three TaHAG1 homoeologs was induced quickly under HS and then gradually increased in a similar pattern with the time of stress prolonging (Figure 1c). To explore the function of TaHAG1 in the regulation of thermotolerance, we obtained transgenic wheat plants that either had TaHAG1 overexpressed (OE) or silenced via RNA interference (RNAi). The OE and RNAi plants showed similar phenotypes with wild-type Fielder under normal conditions (Figure 1d). Upon HS treatments, both Fielder and transgenic lines displayed a certain degree of wilting and growth inhibition. However, after recovery, the OE lines presented an obvious increase in fresh weight than Fielder, whereas the RNAi lines showed a pronounced wilting phenotype than Fielder and could not recover growth (Figure 1d,e). In addition, the OE lines kept more chlorophyll content and lower membrane damage than wild-types and RNAi lines after HS (Figure 1f,g). To further validate the function of TaHAG1 in thermotolerance, the knockout lines of TaHAG1 were generated using CRISPR/Cas9 system. The mutation simultaneously in three homoeologs of TaHAG1 was lethal for wheat. Thus, the lines with simultaneous mutations at the two homoeologs TaHAG1-A and TaHAG1-B (1 bp insertion in TaHAG1-A and 25 bp deletion in TaHAG1-B, respectively) were selected for analysis. As expected, the KO lines exhibited stronger defects in thermotolerance as compared with Fielder plants under HS condition, including reduced fresh weight, more wilted leaves, lower chlorophyll content and severe membrane damage (Figure 1h–j). We further examined the thermotolerance of transgenic lines with wild-types under field conditions. The plants were covered with manually constructed thermo-stress tents in grain-filling stage for 30 days, with uncovered individuals grown alongside as controls (Figure 1k,l). Under HS conditions, all OE lines exhibited much better fitness than the Fielder, including higher thousand kernel weight and grain width. In contrast, RNAi and KO lines exhibited severe inhibition compared with Fielder in term of these traits (Figure 1m,n). Meanwhile, no significant differences were found in agronomic phenotypes between OE, RNAi, KO and Fielder under control conditions, suggesting TaHAG1 contributes to thermotolerance without negative consequences for other developmental traits. To explore the molecular basis of TaHAG1 in the regulation of thermotolerance, we performed RNA-sequencing in seedlings of Fielder and TaHAG1-OE after HS treatment. We reasoned that TaHAG1-regulated genes involved in thermotolerance would be enriched in the clusters where their expressions were upregulated in OE lines compared with wild-type and induced by HS. Based on this, 663 genes were identified and considered as TaHAG1-regulated genes in response to HS. The most significantly enriched classes of these genes were those responsible for nucleosome organization, which was consistent with the role of TaHAG1 in histone modification (Figure 1o). Moreover, cellular component of plasma membrane and thylakoid was greatly enriched, indicating the membrane and photosynthetic system of TaHAG1-OE might be better adapted to HS treatment, which was further supported by lower electrolytic leakage and higher chlorophyll content in TaHAG1-OE plants. Notably, a series of typical genes reported to be involved in the regulation of photosynthetic apparatus were detected, such as TaG1 and TaPSBR1 that involved in stable assembly of PSII were upregulated significantly in TaHAG1-OE lines than wild-type plants under HS (Figure 1p). These results are consistent with our observation that TaHAG1 enhanced maximal PSII quantum efficiency (Fv/Fm) in TaHAG1-OE lines under HS conditions


A functional analytic approach to the linearized collisionless Vlasov equation is presented utilizing a resolvent integration technique on the resolvent of the transport operator evaluated at a particular point. Formulae for the eigenfunction expansion are found for cases in which the plasma disperion function Λ has first and second order zeroes. Special care is taken in the study of real zeroes of Λ culminating in new results for this case. For a simple zero of Λ with nonvanishing imaginary part the van Kampen–Case discrete modes are reproduced. The results are used to obtain the solution to the initial value problem.


The board common calculation method by VB software with the powerful calculation function of VB software,according to the way of computer aided calculation,the solution method of ethanol propanol two element ideal system theoretical plate sieve plate distillation column number and total plate efficiency was proposed. The calculation process was intelligent,simple operation and accurate result eliminating the rough,tedious and time- consuming manual calculation. The method had important significance for teaching the principles of chemical engineering.


This study presents data from a year-long teaching experiment which illustrate how two seventh graders modified their multiplicative thinking and interacted with their representing symbols in the context of combinatorial problem situations. Damon was at the process of construction of recursively multiplicative thinking by modifying his multiplicative reasoning, but Carol appeared to remain at the stage of a binary multiplicative scheme. The two students'struggles with their representing symbols or represented symbols by the teacher show that even well-organized symbolic systems from teachers'perspective do not necessarily help students advance their mathematical capacity.


The article analyzes in detail the wedding meal Ukrainians of Omsk Preirtysh region in the XX — early XXI century. A description of all stages of the wedding ceremony and the meal involved in it is given. Particular attention is paid to the symbolism of the main traditional wedding dishes.


The computation and analysis of response of multi-story sliding isolated structures can be simplified using the generalized double-mass model (double-mass model or single-mass model). This paper first discussed the selection of mass ratio of double-mass model for sliding structures by use of the mode decomposition theory, in this base, through the numerical experimentation method, studied the precision and applicability of the generalized double-mass models under different levels of factors of the earthquake wave types, earthquake wave amplitudes, story numbers of sliding structures, natural periods of the superstructure, sliding friction coefficients and mass ratios. The research indicated that all these factors have influences on the model precision, the natural period of the superstructure and mass ratio of the analysis model are the most sensitive two factors to the model precision. This paper suggested an optimized mass ratio for double-mass model, and the model is applicable for analyzing the maximum displacement response of sliding base-isolated buildings with natural period of the superstructure less than 1 s, and the error of the model of sliding displacement response can be restricted within 14%.


Henry Overman reviews the the government's new National Planning Policy Framework, published this week. He argues that while the Framework's presumption in favour of sustainable development is laudable, it is not forward looking enough, and does not encourage new development as much as it should.


Biodiesel is synthesized using soybean oil and anhydrous methanol as raw materials via ZS/HY-SBA-15(zirconium sulfate modified micro-mesoporous composite zeolite) made by impregnation method as catalyst through transesterification.The optimal conditions were found to be a molar ratio of methanol to oil of 12,a catalyst dosage of 3%,a solvent dosage of 30%,a reaction temperature of 120 ℃ and a reaction time of 6h employing(30%)ZS/(10%)HY-SBA-15 as the catalyst.Under the conditions,the yield of biodiesel may reach 96.78%.The performance of biodiesel obtained was in accordance with that of 0# diesel.


In recent years, the propagation saw test (PST) gained popularity for both avalanche professionals and backcountry recreationalists. A limiting factor of the PST is the additional time required to isolate a column on the sidewall of the snowpit. Since I often have limited time to dig multiple pits during a work day, this past season I examined the effectiveness of conducting cross-slope PSTs (CPST). The CPST is simply a PST done across, rather than up, the slope. It is more efficient than the PST, particularly after conducting an extended column test (ECT). I collected a total of 28 data sets, including standard PSTs, CPSTs and ECTs during the 2013/14 winter season. My data indicate that CPSTs share similar critical cut lengths as standard PSTs, with 75% of critical cut lengths falling within 10 cm of each other. Though it is necessary to collect more data to make solid conclusions, there may be a slope angle effect where CPSTs begin to have shorter cut lengths than standard PSTs as slope angles increase above 28 or 30 degrees. A drawback of the CPST is that some weak layers may be more difficult to follow than in a standard PST. Currently, the CPST cannot be qualified as a standardized stability test, but I hope to continue to collect additional data to better understand how CPSTs are related to PSTs and snowpack stability.


Non linear programming is the most important optimizations. One of them is  linear fractional programming problem. On some applications of linear programming problems, the coefficient on the model often can not be determined precisely. One method to solve this linear programming problem is to use an interval approach, where uncertain coefficients are transformed into the form of intervals. The linear fractional programming problem with interval coefficients in the objective function is solved by the variable transformation. The transformation was introduced by Charnes and Cooper. In this method a combination of the first and the last points of the intervals are used in place of the intervals. This research showed that optimization linear fractional programming problems with interval coefficient in objective function can be transformed with Charnes and Cooper's transformation.


The dynamic viscoplastic memorial nested yield surface model of soil has been constituted previously and published on the Vol.28(No.10) of Chinese Journal of Geotechnical Engineering. In this paper,the model is developed and the model parameter α θ,the point angle of cone-shaped yield surface,doesn't assumed to change by the supposed rules. According to the reality changes of nested yield surfaces,the incremental expressions of model harden parameters are deduced. These developments on the model perfecte its theoretical foundation and are consistent with the test results. At last,the earthquake responses of a site is analyzed by using the developed model and primary model respectively;and the differences of two models are analyzed.


A method is suggested for calculating recurrences and statistical characteristics of the intensity of solar radiation for an observation period on the basis of recurrences of different levels of cloudiness and such blocking meteorological phenomena as fog, smoke, dust storms, haze, and precipitation, and corresponding transmission coefficients of solar radiation. A method carried out according to data from actinometric and meteorological stations of Tamdy showed fairly good agreement of calculated and observed values


This paper studies algorithms for the Disjunctive Temporal Problem (DTP) a quite general temporal reasoning problem introduced in [12]. This problem involves the satisfaction of a set of constraints represented by disjunctive formulas of the form x1 - y1 ≤ r1 V x2 - y2 ≤ r2 V ... V xk - yk ≤ rk. The paper starts sketching why DTPs are potentially very useful in plan management applications, then analyzes the current solutions to DTP, and introduces a constraint-satisfaction problem solving algorithm where different aspects of current DTP's literature are integrated. This basic algorithm is then improved exploiting the quantitative temporal information in the "distance graph". Using this knowledge an incremental version of the forward checking is obtained and shown to be competitive with current best results. The whole approach allows to understand pros and cons of the current algorithms for the DTP and suggests further future developments as discussed in the final part of the paper.


Eddy current thermography (ECT) is an active thermography method. The inductive excitation generates Eddy currents in an electrically-conductive specimen. In presence of defects, the eddy current flow is affected by these discontinuities leading to changes in the temperature distribution in the specimen around the defects. These changes are observed by an infrared camera. In this paper, we present a robotic application of the method. Simulations are performed using COMSOL ® Multiphysics by varying different parameters. Experiment is realised on an aluminum plate with cracks of different sizes created artificially in our laboratory. The resulting images are reconstructed with a dedicated algorithm.


The reduction in overall mortality, cardiovascular mortality and the occurrence of myocardial infarction in patients treated with AT1 blockers is comparable with the use of ACE inhibitors. In addition, there is a lower proportion of AT1 blockers withdrawal of treatment due to adverse reactions.Key words: ACE inhibitors - AT1 blockers - cardioprotection - hypertension - renin-angiotensin-aldosteron system.


The paper deals with national culture influence on countries' innovative development. Main goal is to analyze the impact of national culture on innovative activity on the macroeconomic level. The article explores Geert Hofstede's cultural dimensions that allow assessing influence of main human values and mentality special features on behavioral patterns. The authors research an interaction between long term orientation and uncertainty avoidance and a level of innovative activity in various countries by means of a multivariate correlation analysis. The authors use – hightech exports (% of manufactured exports) for innovative activity assessment. The authors conclude that uncertainty avoidance influences innovative activity. According to the research an association between uncertainty avoidance and innovative activity is inverse, this fact corresponds with Hofstede's theory, the lower uncertainty avoidance, the higher innovative activity level. According to Cheddok scale an association between uncertainty avoidance and high-tech exports is strong, a correlation rate is -0,7. As far as long term orientation is concerned, the authors did not find any association with innovative activity level.


Structures of polynomial-time computable distributions and polynomial-time many-one reductions on randomized decision problems are investigated. The scope is widened from the most studied class DNP (distributional-NP) to the class ANP (average-NP), which consists of randomized decision problems accepted by nondeterministic Turing machines in average polynomial time. Results indicate that the structures of average-case complexity classes are very different from their counterparts in worst-case complexity due to the complex structures of probability distributions and distribution functions.<<ETX>>


The implementation of outcome-based education (OBE) is often controversial especially among faculty members who are tasked with implementing the requisite changes that come with the new system. The study aimed to describe the knowledge, attitudes, and perspectives of faculty members teaching undergraduate Accountancy, Office Administration, and Business Administration courses at a state university in the Philippines regarding OBE. A descriptive qualitative study design was used. A focus group discussion was conducted with all faculty members with at least one-year experience teaching undergraduate accountancyor management-related courses at a state university in the Philippines. From the FGD, an anonymized transcript was generated, which was analyzed thematically. Most faculty members satisfactorily defined what OBE is. However, when asked what their role is in an OBE learning environment, they were not able to provide conclusive answers. They think that OBE is a necessary upgrade to the traditional system, and is needed to keep education competitive in the face of ASEAN integration. Most participants claimed that they are ready to embrace OBE, but a few expressed reservations towards it. Furthermore, they suggested various improvements for the faculty, the learning infrastructure, and ways to ensure that OBE is implemented well. These findings underscore the need for trainings and dissemination of best practices for OBE implementation, as well as systemic changes in the college to which the faculty members belong to ensure optimal implementation of OBE.


The world of project management (PM) is diverse and extensive, as is the resulting tool selection on the market. Despite the wide variety of tools available, many PM activities are carried out using self-developed spreadsheets that have been tailored to meet the needs of the project. The authors have evaluated experiences from several completed projects and recognizes the need for a systematic model based on a formalised and tool-independent table structure. The goal of this work is to use a powerful Petri net (PN) model for mapping and simulation, taking advantage of the model's benefits. Thus, an effective and flexible methodology for PM can be realised. In order to use the concept of PN for this purpose, appropriated extensions and necessary interpretations from the area of high-level timed Petri nets must be used. Moreover, PM has to be brought to the same description level as PN. The concept of this proposed method is to enter all data, initial plan inputs and intermediate status updates into a defined table structure. A PN is then automatically generated in the background or updated to reflect the current status of the project. Simulations should be performed on the PN models, and their results should be put back into the table. The advantages of the PN concept can thus be fully exploited and become useful for a project manager, even if he or she does not have any PN knowledge. This article presents an overview of the proposed formalised methodology, its suitability to PM, and its benefits. The method itself can be applied to a wide range of projects. Focus is placed on how to transfer certain areas of PM into the introduced PN constructs and interfaces. Examples are used to illustrate how to transform PM activities and their related information into the selected PNs.


Even in nations with well-established comprehensive strategy with the aim to achieve full coverage to rehabilitation, half of the stroke patients remain dependent on activities of daily living (ADL) 3 months post stroke. Therefore, in the last few years part of the scientific community is increasingly focusing on development of innovative therapeutic concepts to increase effectiveness of stroke rehabilitation. In the following article we discuss a new approach in recovery of stroke patients with the use of a mirror. A mirror is positioned orthogonally in front of a patient. The less-affected arm is moved while the patient is observing this movement in the mirror. The illusion is created that the affected arm is moving. Despite the enthusiastic response that mirror therapy has received, not every stroke patient benefits from mirror therapy. This circumstance reflects that an individualised therapy approach is necessary for an effective rehabilitation regime of stroke patients.


ABSTRACT:Livelihood diversification is an adaptation and a coping mechanism used by individuals to mitigate tragic episodes, and to build buffer against social, environmental, health and economic shocks, as well as other extreme events which impact disproportionately on people's lives, in a bid to ensuring sustained livelihood and improved living conditions. The effect of livelihood diversification on farmers' well-being in South-West Nigeria was therefore investigated using the dataset elicited from 359 farmers randomly drawn from the study area. The data were analyzed with composite score technique, simpson index of diversity, fractional probit, and fractional heteroskedastic probit models. The results revealed that livelihood diversification pattern among the farmers was at a moderate level, while farmers' categories of well-being status were partly associated with the levels of livelihood diversification in other sectors considered remunerative with high returns. Findings also indicated that age of the farmer, primary occupation, farm size, neighborhood effect, incidence of shocks and farmer's food insecurity status had significant relationships with the rate of livelihood diversification in the study area. Meanwhile, age of the farmer, years of formal education, livelihood diversification, access to credit, neighborhood effect, primary occupation of the respondents, and farming experience significantly influenced farmers' well-being status. In essence, this study has provided converging lines of evidences and demonstrated that livelihood diversification and other farmers' and farm based characteristics were meaningful predictors of the differences in the categories of farmers' well-being status in the study area. Arising from the findings, the study recommended human capital development through free and/or affordable educational system in the rural areas, as well as diversification of income sources among the farmers, while informal social protection can also be scaled up through social networks and neighborhood effect hinged on collective norms of solidarity, reciprocity, altruism and obligations towards achieving an effective cultural and social driven development.


This investigation sought to determine the relevance of anaerobic and aerobic-based measures to competition level and bout outcome in mixed martial arts competitors. For the primary analysis, seven higher-level and eight lower-level male mixed martial arts competitors were compared across a series of short-term anaerobic (sprints at 10 and 20 m), repeated maximal effort (repeated sprint ability), and intermittent aerobic tests (Yo-Yo Intermittent Recovery Level 2)). For the secondary analysis, data were then pooled so relationships could be explored between test performance and percentage of bouts reaching a decision. Cohen's d effect sizes and qualitative magnitude-based inferences were calculated to describe the differences between groups. These same descriptors were used to interpret the output of the regression analysis used to predict decision percentage. Superior performances by the higher-level group were revealed across most variables to a non-trivial magnitude. Furthermore, it was likely that a decrease in short-term anaerobic performance or an increase in intermittent endurance capacity positively related to an increased likelihood of bouts lasting the full scheduled duration. These findings indicate the importance of anaerobic and aerobic qualities to mixed martial arts performance and combat methods.


ABSTRACT We examined the survivorship of wood frog (Rana sylvatica) tadpoles when exposed continuously to various concentrations of sodium chloride, a common component of road salt. A high environmental concentration of NaC1 (5.6 g L−1) resulted in decreased survivorship within a short period of time compared to controls; lower concentrations of NaC1 also decreased survivorship, but the effect took longer to appear. These results indicate that environmental salinization, as results from road salt run-off, will have negative consequences for the wood frog.


Microwave non-destructive testing (NDT) is promising for non-contact and speedy survey for air cavity or metallic rust buried into concrete media in tunnel or highway. As an imaging algorithm for the above application, the distorted born iterative method (DBIM) is one of the promising options to retrieve not only target's location but its dielectric property, which is useful for material characterization. However, in an actual NDT scenario, scattered data from limited direction are available, which makes the problem more ill-posed. In this paper, the incorporation algorithm with radar approach as the range points migration (RPM) method, which offers a prior estimate of the region of interest (ROI), substantially reduces the number of unknowns in the DBIM. Furthermore, the variational Bayesian expectation maximization (VBEM) algorithm is introduced in the above incorporation. The finite-difference time-domain (FDTD) based numerical simulations demonstrate that the proposed method achieves faster convergence and more accurate results compared with that without the prior ROI estimation.


A technique to remove the lateral strain component from PVDF gauge signals in non‐1D flow has been assessed. A strain compensation factor for uni‐axially stretched PVDF gauges was derived using a gas gun technique. The factor agreed with the value derived by Charest and Lilly for bi‐axially stretched PVDF. The method has been tested in a series of experiments in which PMMA or steel blocks were shocked by a centrally‐initiated explosive charge in contact with their surfaces. The divergent shock front was monitored with embedded PVDF stress gauges. Strains were measured experimentally using embedded bi‐directional and uni‐directional strain gauges. Outputs from bi‐directional and uni‐directional strain gauges were compared and found to be consistent. The strain‐compensated stress profiles were then calculated by applying the derived strain compensation factor. The strain compensation technique has been used to adjust previously reported AWE data on the shock initiation of explosive.


Many U.S. cities are engaging in sustainability initiatives to make their cities more livable and to confront the problems of population shifts, waste disposal, and greenhouse gas emissions. Sustainability reporting can be useful for cities that have an interest in communicating their economic, environmental, and social impacts to their stakeholders. This article describes how the City of Bloomington, Indiana published its first Global Reporting Initiative (GRI) sustainability report through a collaboration among two Indiana universities, a for-profit sustainability dashboard company, and the city. This is an example of a partnership that benefited students and the community. A brief history of the city along with a description of its sustainability initiatives and the resulting GRI report are presented.


Building the coal spontaneous combustion index gases programmed temperature experiment table,the paper studied the impact of coal gas produced laws in the temperature-programmed experiments when the experimental conditions changed,such as the experimental initial temperature,temperature-programmed rate,dry air flow,coal sample size and the weight of coal sample etc.The initial temperature was regard as the critical factor,the temperature-programmed rate and the weight of coal sample took the second place.


In this letter we report an experimental study of a method for controlling the length (t/sub p/) of ultrashort pulses which presents the possibility in principle of adjusting this length over the range T/sub a/ks> or approx. =t/sub p/> or approx. =..delta../sub g//sup -1/ with completely reproducible pulse characteristics (T/sub a/ks the axial period, and ..delta..V/sub g/ the spectral again width of the active medium of the laser). This method combines two other methods, which have been studied previously. (AIP)


The protein profiles of the culture liquids of recombinant Penicillium verruculosum strains that secreted an Aspergillus niger β-glucosidase (BGL series) or a Penicillium canescens xylanase A (XYLA series) have been previously analyzed. It was shown that the producers were divided into two groups according to the target protein content: 75-85% (1) and no more than 15% (2). It was established in this work that the copy number of the target gene bgll in the recombinant strains correlated with the β-glucosidase content in the BGL-F10 and BGL-F12 enzyme preparations. However, this proportion was violated in the direction of decreasing the xylanase A relative amount: the target enzyme content of 50% and 17% in the XylA3 and XylA4 preparations corresponded to 20-22 and 6 copies, respectively, of the xylA gene. We believe that this effect is a result of titration of positive transcription factors in the P. verruculosum XylA3 strain containing 20 to 22 copies of the cbhl gene promoter.

Penicillium verruculosum, real-time PCR, gene copy number

This work was partially supported by the Russian Foundation for Bsic Research (Project number: 18-29-07070).


We study the average price impact of a single trade executed in the NYSE. After appropriate averaging and rescaling, the data for the 1000 most highly capitalized stocks collapse onto a single function, giving average price shift as a function of trade size. This function increases as a power that is the order of 1/2 for small volumes, but then increases more slowly for large volumes. We obtain similar results in each year from the period 1995 - 1998. We also find that small volume liquidity scales as a power of the stock capitalization.


This paper presents optimal aerodynamic consideration on impeller, diffuser and volute for a MEMS centrifugal compressor. It is well-known that aerodynamic matching of impeller, diffuser and volute controls total performance of centrifugal compressor. There are few systematic works concerning to aerodynamic matching of these elements for large-scale centrifugal compressors as well as MEMS counterparts. Two kinds of impellers, four kinds of diffusers, and three kinds of volutes are investigated by means of CFD analysis, in order to improve the adiabatic efficiency and to establish design guideline for the MEMS centrifugal compressor under constraint small-scale structure. As a result, the combination, to which highest adiabatic efficiency is expected, is impeller with splitter blade, low solidity tandem cascade diffuser and volute with the outlet radius of 16 mm.


On September 30, 2017, the Supreme People's Court of China and the judiciary jointly issued the "Opinion on the implementation of the pilot project for lawyer mediation" (hereinafter referred to as the "pilot opinion"). This pilot opinion declares the official appearance of the new lawyer mediation system in China.
There may be two ways for lawyers to participate in mediation. One way is to participate in the mediation as the attorney of one party and firsthand draw an agreement with the other party. The other way is to lead the mediation in the capacity of an independent and neutral third party to induce the two parties to draw an agreement based on equitable negotiation.
Before the announcement of the pilot opinion, the way for lawyers to participate in mediation in Chinese judicial practice was limited to the first way. However, with the announcement of the pilot opinion, the second way for lawyers to participate in mediation in China has been established as one of lawyers' working methods.
This paper examines lawyer mediation in its narrow sense as a way of dispute resolution, in which the lawyer leads mediation as an independent, and objective third party to derive concessions and agreements between two parties. First, the background and process of the introduction of the Chinese lawyer mediation system is examined, the concrete contents of the lawyer mediation system are examined thereafter, the lawyer mediation system is evaluated, and finally, implications are presented.


With the rapid development of cloud services, more and more people use cloud services to store personal image privacy. However, cloud services lack security, which leads to the leakage of personal privacy. Although some scholars have proposed that images be encrypted before being uploaded to cloud services, it will cause the images to lose their availability. Recently, Zhao et al. proposed a thumbnail preserving encryption scheme, which can ensure the security of the image while maintaining the visual usability of the image, but the encryption efficiency of the algorithm is low. Therefore, this paper proposes a thumbnail preserving encryption scheme based on bit plane scrambling. In this scheme, a new one-dimensional chaotic system is proposed for the image chaos process. An improved Zigzag transformation method is proposed to change the position of pixels. The control parameters in the new one-dimensional chaotic system have a large value range, which ensures that the key space of the encryption algorithm is large enough. The improved Zigzag transformation method adds random numbers to improve the randomness of the encryption process. Experimental results show that the scheme has high encryption efficiency, and can make the encrypted image retain the visual usability of the original image, balancing security and usability.


The recent advances in genomic microarrays design provide the possibility to retrieve hundreds of thousands of significative genetic features from patients at affordable costs. Understanding if non-linear interactions (epistatic relationships) between these features determine or not the arising of complex common multifactorial genetic diseases is a critical task for human geneticists. The algorithms able to detect such relationships, like the Multifactor Dimensionality Reduction (MDR) algorithm, are computationally expensive and their practical utility is very often limited by the amount of time required by the analysis. This paper presents three hardware-accelerated implementations of the MDR algorithm, tailored for many-core processors, Xilinx Virtex-5 FPGAs and generic GPUs respectively. These implementations provide timing performance improvements of up to two magnitude orders with respect to the software implementation.