The objective of this study was to assess the variation in the pH, ruminal ammonia, nitrogen compound balance (BN) and microbial synthesis (Nmic) of 12 Holstein cows distributed in three 4 × 4 Latin squares, fed diets containing soybeans in different forms: only soybean meal (SM - control diet), raw soybeans (RS), toasted soybeans (RST) and soybean meal plus 5% urea (SMU), using corn silage as bulk. The microbial protein synthesis was estimated using the purine derivatives in the urine and the milk. Blood samples and spot urine were collected, approximately four hours after the morning meals. There was effect of the diets on the urine volume (UV) and the urea excretion in the urine (UEU). The smallest urine volume (18.84 L) was observed with soybean meal + urea. Urea excretions in the urine were similar among the diets containing raw soybean (532.98 mg/kgPV) and toasted soybean (524.41 mg/kgPV) and differed between the soybean meal (561.56 mg/kgPV) and soybean meal + urea (575.71 mg/kgPV). The way of supplying soybean did not affect the nitrogen balance or the ureic nitrogen concentrations in the Plasma (NUP), but they had a significant effect on the ureic nitrogen in the milk (NUL) whose greatest mean was obtained with raw soybean (15.66 mg/dL). The means of alantoina in the urine (416.45 mmol/dia), milk (12.78 mmol/dia), total purine derivatives (468.30 mmol/dia), microbial protein synthesis (287.33 g/dia) and the efficiency of the microbial synthesis (133.06), expressed in g of CP/kg of consumed TNT did not differ among the diets. The diets tested did not the nitrogen balance or the microbial production, but the addition of raw soybean grains increased nitrogen levels in the milk.


This article articulates a model for the "engaged campus" through academic programs focused on community engagement, broadly construed. Such academic programs–usually coalesced in certificate programs, minors, and majors–provide a complementary vision for the deep institutionalization of civic and community engagement in the academy that can revitalize an "apprenticeship of liberty" for students, faculty, and academic staff.


We applied saturated cavity ringdown spectroscopy (CRDS) to the measurement of the Doppler-free absorption spectrum of the Balmer-α line of atomic hydrogen in an inductively coupled hydrogen plasma. The spectrum was used for estimating the electric field in the sheath region in the vicinity to a biased electrode. The absorption frequency (the absorption coefficient multiplied by the speed of light) and the saturation parameter were estimated by fitting the experimental ringdown curve with the theory reported by Giusfredi and coworkers (Phys. Rev. Lett. 104 (2010) 110801). We detected the Lamb dip corresponding to the 2p 2 P o 3/2 - 3d 2 D 5/2 transition in the absorption spectrum in the field-free condition. We observed the change in the Lamb dip spectrum when we repeated the measurement in the sheath, and we succeeded in estimating the sheath electric field of 220–230 V/cm at a distance of 1.8 mm from the electrode which was biased at -100 V with respect to the ground potential. The experimental results indicate the potential of saturated CRDS for the measurement of sheath electric fields in plasmas.


An automatic panorama recognition and stitching method based on graph structure was proposed to solve the multiple images recognition and matching problem. With multiple unordered images of user input, the method can automatically finding overlapping portion between images, and stitch them. First, the MOPS feature points were detected from the input images, and using kd-tree nearest neighbor search to perform fast feature matching between images. The motion model between any two images can be established by RANSAC algorithm based on the correspondence of feature points, and robust verification by a probabilistic algorithm. The automatic recognition of multiple panoramic images problem can be solved by building undirected connected graph corresponding to image matching relationship. Finally, a recursive algorithm was used to do depth-first traversal of the established undirected connected graphs, and multi-band blending algorithm was used to eliminate stitching seam. The experiments showed that multiple unordered images can be matched and recognized automatically, and panoramas can also be stitched automatically and seamlessly. Keywords-feature detection; feature matching; image recognition; image matching; image stitching


This study explored the factor structure of Darkenwald and Valentine's Adult Classroom Environment Scale (ACES). The Student Ideal form of the ACES was administered to 449 adult students from a variety of educational settings and a factor analysis was performed. All but 15 of the original 49 items loaded clearly with a five-factor orthogonal solution, which only partially supported the seven dimensions proposed by Darkenwald and Valentine. A revised version of the scale was then administered to an additional 287 adult students. A second factor analysis largely confirmed the stability of the five factor solution, although a tentative sixth factor was identified.


The utility model relates to a test-bed device for a cutter of a shield machine. The thrust of the test-bed device reaches100 tons, and the driving torque of a cutter disk reaches 1000 KN.m. By adopting the test-bed device, various cutters of the shield machine can be installed on the test-bed device for realizing cutting simulation tests, the test-bed device can simulate a test-bed capable of providing provides various geological conditions, can accurately obtain the loading condition of each part of the cutter to carry out analysis and calculation and can ensure the manufacturing quality of various cutters of the shield machine and the adaptability of the cutters to various geological conditions, so that the appropriate cutters can be better chosen according to the geological conditions, and the design and manufacturing scheme can be optimized based on the geological characteristics. The test-bed device is composed of a boost hydraulic cylinder, a rack, a simulating rock-soil bin, a simulating shield machine cutter disk, a rotation support, a transition connecting disk, a bearing pedestal, a planetary speed reducer, a variable frequency motor, a transmission base, a signal system, a signal control system, an oil cylinder supporting boots, a guiding device, a gear sleeve coupling and a pin coupling. The test-bed device has a simple structure, is easy to manufacture, ensures the convenience and speediness of experiments and is labor-saving, time-saving and strength-saving; the wastage of the cutter of the shield machine is reduced, and the service life of the cutter is prolonged; and the work efficiency of the test-bed device is improved.


The purpose of this study is to see the quality of education services, where the implementation of accreditation policy is said guaranteed. From the sector of implementation, education is said to be of high quality if all the processes goes well according to the applicable standards. The purposes of this papers, researches want to know the optimization strategy used by SMPS Darul Amin in creating an excellent education services. This research is qualitative with descriptive survey technique. Sources of this information Principa himself , Deputy of curriculum, and several employees. The result of this study showed that SMPS Darul Amin achieved A for accreditation, were inseparable from essential factors, which is the forms of the system and values in the guise of superior school culture. Accreditation refers to the process being manipulated then has an instant impact. On the other side, the accreditation as a result from the process of creating school cultural result is far-reaching and long-last. Cultural establishment that makes it easier for members to adjust to the environment, work, and other member of organizations, helps in growing commitment and encouraging human resources to reach goals.


This paper explores the required environmental information according to relevant stakeholders and how this requirement influences environmental management accounting (EMA) practices. By comparing and contrasting empirical evidence collected from in-depth interviews with several key relevant personnel from two seaports, this paper identifies two high salient stakeholders, namely the government agency and foreign co-owner where each of them had demanded detail information of scheduled waste production, and energy and fuel consumption (including carbon emission). Both seaports are found to adopt the EMA framework to assist environmental data collection. The energy and fuel consumption and carbon emission are intensively monitored while not much attention is given on water usage given the absence of definitive stakeholder on water management. Once the cost-savings potential of the information was realised, the collected information are then widely used to enhance efficiency.


ABSTRACT This study is the second in a planned series of qualitative inquiries to investigate how some Australian educators use differentiated instruction (DI) in a secondary school setting. A small-scale study was conducted using individual, semi-structured interviews with seven teachers and two school leaders via Teams, a video conferencing platform. Using thematic analysis, two major themes were identified in the data, namely: perceptions of DI and key guiding DI principles. Results indicated that teachers and school leaders have a good understanding of differentiation and are responsive to the needs of the diversity of student abilities in this educational setting. This includes pedagogies such as designing learning activities to maximise educative opportunities for all students, pre-planning lessons and collecting student data to inform teachers' understanding and capacity to plan for student readiness differences, using scaffolded formative and summative assessment, arranging flexible learning groups, and employing adaptable teaching processes that support all learners. The findings are a starting point to further explore and expand on how Australian educators use DI strategies and approaches in their mainstream schools.


As long as we know, little attention has been given to evaluating roles of ZnO nanoparticles (ZnONPs) in plants grown under salinity stress. In the present study, biochemical and molecular responses of salt-stressed soybean cv. Giza111 under different ZnONPs were assessed. Treatment with a high NaCl concentration (250 mM) alone caused a significant reduction (65%) in germination percentage as well as a significant decrease in all measured growth parameters (root length shoot height, fresh and dry weight of roots and shoots) and photosynthetic performance (Fv/Fm) compared to control plants. In addition, malondialdehyde (MDA) & proline contents, and activities of antioxidant enzymes (catalase CAT, peroxidase POX and superoxide dismutase SOD) were highly increased. In contrast, presoaking of soybean seeds with different concentrations of ZnONPs (25, 50, 100, 200 mg/L) stimulated the growth of stressed plants which was exhibited by improved growth parameters and photosynthetic performance as well as lower levels of proline and MDA in stressed plants particularly at ZnONPs concentration of 50 mg/L compared to controls. Moreover, isozyme analysis of CAT, POX and SOD showed variable pattern of alleles at 50 mg/L ZnONPs. Accordingly, these results recommend application of 50 mg/L ZnONPs for improving the productivity of soybean cultivated in saline soils.


Snowfields are challenging terrain for lightweight (<50 kg) unmanned ground vehicles. Deep sinkage, high snowcompaction resistance, traction loss while turning and ingestion of snow into the drive train can cause immobility within a few meters of travel. However, for suitably designed vehicles, deep snow offers a smooth, uniform surface that can obliterate obstacles. Key requirements for good over-snow mobility are low ground pressure, large clearance relative to vehicle size and a drive system that tolerates cohesive snow. A small robot will invariably encounter deep snow relative to its ground clearance. Because a single snowstorm can easily deposit 30 cm of fresh snow, robots with ground clearance less than about 10 cm must travel over the snow rather than gain support from the underlying ground. This can be accomplished using low-pressure tracks (< 1.5 kPa). Even still, snow-compaction resistance can exceed 20% of vehicle weight. Also, despite relatively high traction coefficients for low track pressures, differential or skid steering is difficult because the outboard track can easily break traction as the vehicle attempts to turn against the snow. Short track lengths (relative to track separation) or coupled articulated robots offer steering solutions for deep snow. This paper presents preliminary guidance to design lightweight robots for good mobility over snow based on mobility theory and tests of PackBot, Talon and SnoBot, a custom-designed research robot. Because many other considerations constrain robot designs, this guidance can help with development of winterization kits to improve the over-snow performance of existing robots.


This paper deals with the designing and implementation of digital code-shifted reference (CSR) transceiver in the hardware. By changing the physical properties of the transmission, the security of the transmission is improved without the help of higher level security options. CSR provides a simple manipulation of the physical property of the transmitting data without the use of precise timing device and multiple oscillators. The CSR transceiver helps us to transmit and receive the data using the help of security added to the transmitting data, which will protect the data from eavesdropping. The design of the transceiver is implemented in custom developed field-programmable gate array and the corresponding outputs are simulated.


Hyperthermia treatment of tumors (43-47°C) is used to sensitize breast cancer tumors to radiotherapy. Thermoradiotherapy significantly increases complete response rate and provides a treatment modality for more aggressive forms of the disease for which treatment options are generally more limited. However, the cellular mechanism underlying hyperthermia-induced radiosensitivity remains unclear. To better understand this phenomenon, we analyzed microarray data from four cell lines following treatment at 45°C for 30 minutes (Gene Expression Omnibus GSE48398). Three of the cell lines, MDA231 (37ºC, n=6; 45ºC, n=3), MDA486 (37ºC, n=6; 45ºC, n=3), and MCF7 (37ºC, n=6; 45ºC, n=6), were malignant breast cancer cell lines. The fourth cell line, MCF10A (37ºC, n=3; 45ºC, n=3), was from non-malignant mammary epithelial tissue. We identified 164 DEGs (adjP < 0.05, Fold change > 2) shared between the four cell lines and 182 DEGS shared by the three cancerous cell lines. Genes involved in radiosensitivity regulation as identified by dbCRSR, a database of radioresistance genes, were significantly dysregulated (Chi-squared test, p = 0.04). Gene ontology analysis using Cytoscape (v3.8.2) found 53 significantly enriched GO terms from an analysis off the DEGs (Benjamini-Hochberg adjP < 0.05). In particular, DEGs were enriched in processes involving G2 cell cycle arrest, apoptosis, and DNA damage checkpoints (adjP<0.005). We identified nine significantly enriched KEGG pathways, which included the ErbB (adjP=0.02), p53 (adjP=0.03), and PD-1 (adjP=0.02) cancer signaling pathways. We constructed a STRING protein-protein interaction network and then identified the 20 DEGs which had the greatest number of interactions. Identification of key genes in regulating hyperthermia-induced radiosensitivity were identified out of these 20 genes using two criteria: 1) overlap with two cancer signaling pathways and 2) involvement in radiosensitivity regulation. PTEN, a tumor suppressor overexpressed by up to 3.2-fold in vitro following hyperthermia, was identified as a key gene that may regulate hyperthermia-induced radiosensitivity in breast cancer. Distinct patterns of gene expression existed between breast cancer cells treated with hyperthermia and non-treated cells. Our data suggest that hyperthermia may exert its effects through arresting cells in the G2 phase, a particularly radiosensitive section of the cell cycle. Understanding the genes and pathways responsible for the heat-induced sensitization of breast cancer will allow us to exploit genetic alterations in tumors and develop non-invasive thermoradiotherapy regimens that more specifically target the tumor. Our study provides the basis for further investigation of genes regulating heat-induced radiosensitization and its molecular mechanism in breast cancer.
 Citation Format: Kevin Jili Tu, Hong Zhang, Dario Rodrigues, Jason K. Molitoris, Amit Sawant, Hem D. Shukla. Gene expression profile analysis of hyperthermia-induced radiosensitivity in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1104.


We detected croased cerebellar as well as uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease by positron emission tomography (PET) using 18F-fluorodeoxyglucose. We studied a series of 26 consecutive, clinically diagnosed Alzheimer cases, including 6 proven by later autopsy, and compared them with 9 age-matched controls. We calculated asymmetry indices (AIs) of cerebral metabolic rate for matched left-right regions of interest (ROIs) and determined the extent of diaschisis by correlative analyses. For the Alzheimer pup, we found cerebellar Ah correlated negatively, and thalamic AIs positively, with those of the cerebral hemisphere and fmntal, temporal, parietal, and angular cortices, while basal ganglia AIs correlated positively with frontal cortical AIs. The only significant correlation of AIs for normal subject a was between the thalamus and cerebral hemisphere. These data indicate that PET is a sensitive technique for detecting diaschisis.


The use of high vigor seeds may be a strategy to reduce problems in seedling development. An efficient method to evaluate seed physiological quality or accelerated aging test. The objective of this work was to verify the physiological behavior of Enterolobium schomburgkii seeds submitted to accelerated aging. Without testing, 120 seeds were divided into four subsamples and placed in the BOD chamber type, set to maintain constant temperatures of 41 oC and 1 Universidade Federal do Acre – UFAC, Rio Branco/AC – Brasil. E-mail: firstname.lastname@example.com 2 Idem. E-mail: email@example.com 3 Idem. E-mail: firstname.lastname@example.com 4 Idem. E-mail: firstname.lastname@example.com 5 Idem. E-mail: firstname.lastname@example.com 6 Idem. E-mail: firstname.lastname@example.com 7 Idem. E-mail: firstname.lastname@example.com 8 Idem. E-mail: email@example.com 346


We consider the optimal average cost of variable length source code averaged with a given probability distribution over source messages. The problem was argued in Csiszár and Körner's book [1]. In a special case of binary alphabet, we find an upper bound to the optimal cost minus an ideal cost, where the ideal cost is the entropy of the source divided by a unique scalar that makes negative costs logarithmic probabilities. Our bound is better than the one given in the book. key words: average cost, variable length code, source coding, balanced tree


Multiple System Atrophy is a rare neurodegenerative disease with alpha‐synuclein aggregation in glial cytoplasmic inclusions and either predominant olivopontocerebellar atrophy or striatonigral degeneration, leading to dysautonomia, parkinsonism, and cerebellar ataxia. One prior genome‐wide association study in mainly clinically diagnosed patients with Multiple System Atrophy failed to identify genetic variants predisposing for the disease.


Telework is an increasingly common feature of government agencies. Long a practice in the private sector, telework is credited with a range of advantages from increased productivity to reduced environmental costs to society. These advantages may not accrue to all employees, however. Large-sample federal government surveys of employees reveal support for many of the claimed advantages of telework, but taken together they also raise significant questions about the seldom-discussed costs of telework: The impact on those barred from telework. In particular, the results reveal what may be disaffection among those whose jobs may be eligible for teleworking under new Office of Personnel Management guidelines, but whose managers have not allowed them to telework. The findings also raise questions about the consequences of expanding telework to larger populations of government workers and suggest the need for further research on the possibility of an emerging telework divide.


One of the main interests of wide-bandgap materials such as diamond, III-nitrides or SiC is their intrinsic ability to perform selective ultraviolet detection. Over the rest, III-nitrides present the undoubted advantage of tuning the absorption edge in a wide spectral range by varying the Al and In mole fractions in AlGaN and InGaN ternary alloys. This property makes them suited for many applications in the ultraviolet and visible ranges. This work presents a short view of fabrication and spectral responses of AlGaN- and InGaN-based photodetectors and their potential use in industrial, environment, military and biomedical research. For visible detection, as an alternative to InGaN bulk-based devices, InGaN/GaN multiple-quantum-well (MQW) photodiodes are also described.


Abstract Musculoskeletal disorders are a significant complication of aging, leading to increased morbidity and mortality. However, current understanding of the mechanisms by which aging affects skeletal health is limited. Osteocytes are the most numerous and long-lived bone cells and play key roles in maintaining bone mass by responding to anabolic signals such as mechanical loading. Energy metabolism is dysregulated in many cells with aging, however regulation of energy metabolism in osteocytes and how this is affected during aging and by mechanical loading remains undefined. To investigate this, we first used IDG-SW3 osteocyte cells to determine the effects of mechanical loading on osteocytes in vitro by applying fluid flow shear stress (FFSS). FFSS increased Pparδ and Cpt1 expression, key promoters of fatty acid β-oxidation (FAO). Pharmacological antagonism of PPARδ or CPT1 resulted in dysregulated expression of key bone remodeling genes and impaired ATP release in response to FFSS. In vivo, mechanical loading significantly increased FAO in tibia cortical bone. However, FAO was impaired in the bones from aged mice. To further elucidate the role of osteocyte FAO, we deleted PPARδ specifically in osteocytes (PPARδ cKO), which resulted in decreased FAO and bone volume in female PPARδ cKO mice. Lastly, treatment of aging mice with the PPARδ activator GW0742 resulted in significantly increased bone mineral content, density and trabecular bone volume. These findings suggest important functions of osteocyte energy metabolism during aging and with mechanical loading on bone and identify PPARδ-driven FAO as a novel therapeutic target for improving skeletal health with aging.


Aim:  This controlled proof‐of‐concept study investigated inhaled insulin (INH) as adjunctive therapy to existing oral antidiabetic agents in subjects with type 2 diabetes.


Objective:To investigate the influence of different surface roughness of titanium discs on the production of TGF-β_1 by osteoblast in vitro.Methods: The primary osteoblasts separated from calvarium of fetal rats were cultured and the third passage osteoblasts was seeded on 5 different surfaces of Ti discs-G(grooved),SB(sandblasted)1~3,TPS(titanum plasma-sprayed) in 24-well plate.Different surface microtopography of the titanium discs and the osteoblasts' morphology on 5 types discs were observed by SEM.TGF-β_1 production by osteoblasts on different Ti discs were measured by ELISA assay.Results: On G surface,osteoblasts were spindle-shaped along the groove,Osteoblasts were cubic,multangular and abundant cytoplasm on SB surface and TPS surface,spreading in all directions.More TGF-β_1 production was detected on rough surfaces(SB,TPS) than G surface(P0.05).An increase of TGF-β_1 production was detected on 3 type of SB surfaces with the increase of Ra.While it was significant lower on TPS surface than on SB3 surface(P0.05).Conclusion: A moderately rough surface is advantageous to the differentiation of osteoblasts and secretion of TGF-β_1.


OF DISSERTATION EFFECTS OF ADIPOCYTE DEFICIENCY OF ANGIOTENSIN TYPE 1A RECEPTORS IN MODELS OF OBESITY AND HYPERCHOLESTEROLEMIA Adipocytes express angiotensin II (AngII) receptors; however the direct effects of AngII at the adipocyte remain unclear. Knockout mouse models of renin-angiotensin system components exhibit reduced body weight, reduced adiposity, improved glucose tolerance, and improved blood pressure when fed high fat diets, which may be due to reduced action of AngII through the AT1aR in adipocytes. Additionally, hypercholesterolemic AT1aR deficient mice are protected from AngII-induced increases in atherosclerosis and abdominal aortic aneurysm (AAA) formation. We hypothesized that deficiency of AT1aR in adipocytes would reduce the development of obesity, obesity-induced disorders, and vascular diseases. To test this hypothesis, we created a mouse model of adipocyte AT1aR deficiency using the Cre/LoxP system. Adipocyte-AT1aR deficiency confers no protection from the development of obesity or obesityassociated parameters. However, low fat fed adipocyte-AT1aR deficient mice exhibit remarkable adipocyte hypertrophy and reductions in adipocyte differentiation. These results demonstrate that AngII is a stimulus for adipocyte differentiation and adipocyte hypertrophy alone is insufficient to initiate obesityassociated disorders. In hypercholesterolemic mice, adipocyte AT1aR deficiency conferred no protection from diet or AngII-induced vascular diseases. Overall these studies suggest the primary role of adipocyte AT1aRs is to promote adipocyte differentiation and the development of small adipocytes.


OBJECTIVE
To assess clinical, radiographic, and functional outcomes following intramedullary nail (IMN) fixation of tibia fractures with an infrapatellar approach compared to a suprapatellar approach.

DESIGN
Retrospective chart review SETTING:: Level 1 trauma centerPatients/Participants: Two hundred and four patients with 208 tibia fractures treated with intramedullary nailing between 2008-2018.

METHODS
A retrospective chart review of tibia fractures was conducted. The clinical and functional outcomes of tibia fractures treated with IMN were compared between groups treated with an infrapatellar approach versus a suprapatellar approach. Multivariate models were created to control for confounding demographic, comorbidity, and injury related confounders.

MAIN OUTCOME MEASUREMENTS
Outcome measures included nonunion, malunion and infection. Subjective functional patient outcomes were assessed using pain interference (PI) and physical function (PF) Patient-Reported Outcome Measurements Systems (PROMIS) scores.

RESULTS
There were 101 patients treated with infrapatellar nailing (49%) and 107 patients treated with suprapatellar nailing (51%). On multivariate analysis suprapatellar nailing was independently associated with decreased risk of malunion (adjusted OR: 0.165, 95% CI: 0.054-0.501, p=0.001) and decreased risk of post-operative knee pain (aOR: 0.272, 95% CI: 0.083-0.891, p=0.032). There was no difference in the rate of nonunion (p=0.44), infection (p=0.45), or PROMIS PI or PF scores.

CONCLUSIONS
Suprapatellar IMIN fixation of tibial shaft fractures is independently associated with lower risk of malunion and post-operative knee pain compared to the infrapatellar approach. However, there are no functional differences between approaches.

LEVEL OF EVIDENCE
Diagnostic Level IV.


study aims to determine the level of state protection provided to rape victims throughout the litigation process under existing laws. However, the prevailing gender bias in society and among law enforcement often leads to victim-blaming, discouraging victims from reporting their cases. Consequently, this study argues for the necessity of providing a victim's companion during the trial


In this paper, we introduce a new concept called partial (h-F)-generalized (and (h-F)-subgeneralized) convex contractions of order 3 (and with rank 3) using some auxiliary functions. Also we present some approximate fixed point results in metric space and approximate fixed point results in metric space endowed with a graph. Some examples are provided to illustrate the main results and to show the essentiality of the given hypotheses. c ©2017 All rights reserved.


The emitter efficiency of InP/GaInAs heterojunction bipolar transistors is calculated taking into account bandgap narrowing in the base, quantum mechanical tunneling, and the exact doping profile in the base. It is found that the emitter efficiency is high and does not limit the current gain of practical devices, up to a base doping level of 1/spl times/10/sup 20/ cm/sup -3/, and up to 400/spl deg/K . It is shown that the base emitter junction saturation current can be controlled over two orders of magnitude by a proper small displacement of the doped layer in the base.<<ETX>>


Eukaryotes contain multiple DNA polymerases which ensure the accurate and efficient replication of the genome as well as protection and repair from endogenous and environmental DNA damaging agents. In most eukaryotes, the main replicative enzymes are DNA polymerases α, δ, and e (reviewed in [


A microburette made from glass capillary tubing is mounted on the mechanical stage of a microscope and filled with insecticide solution to a point at which the meniscus is in the field of the microscope. The magnified images of the meniscus and a calibrated micrometer scale in the eyepiece are projected on to a small screen mounted close to the tip of the microburette so that the scale and the insect being dosed can be seen simultaneously. This feature renders the apparatus particularly suitable for topical application work in which accurate positioning of the dose on the insect is required. When an insect, held in a suction device described, is applied to the tip of the burette, the solution flows out unaided, and stops immediately the insect is removed. With the microburette described, doses from 0.005 to 0.035 μl. can be dispensed to within ±0.00035 μl. The apparatus can be made to cover several other dosage ranges, either lower or higher, by simple modifications which are discussed.


Abstrac t This study aims to determine the effect of transactional analysis counseling in alleviating problems of students who are isolated due to selfishness in class XI MA Nurul Iman Montong Good school year 2017/2018. This type of research is an experiment with Single Subject Design. The subject of this research was a class XI student. Data collection techniques using student questionnaires isolated because selfish and analyzed by using quantitative data in the form of numbers processed using simple statistics and qualitative data described and processed using narrative analysis. The results showed that the initial condition data of students before being given individual counseling was obtained using isolated questionnaires because they were selfish with a total score of 55 which was included in the isolated category, because they were in the range of 50 to <65. Individuals obtained a total score of 42 which was included in the slightly isolated category, because it was in the range of 35 s / d <50. This shows that the Transactional Analysis technique is effective for dealing with the problem of students who are isolated because of selfishness.


People from different backgrounds share opinions about various issues over the Internet. The resulted discussions contain substantial information, from which we can derive the collective intelligence and the crowd wisdom. Several argumentation platforms have been developed to enable online deliberations with large-scale in-depth argumentation for effective online discussions. These platforms host structured argumentation networks that allow complex analytical models to mine the argumentation for collective intelligence. However, not all of those argumentation platforms were developed mobile applications. In this paper, we contribute with the design of a mobile application for cyber-argumentation. This mobile application supports intelligent cyber-argumentation and large-scale discussions and provides meaningful analytics on mobile devices. The platform has incorporated several analytical models to capture collective opinions, detect opinion polarization, and predict missing user opinions. An example is used to illustrate our design and models, and a system usability study of our application is presented. This application is an initial step to bring the multi-sided argumentation and deliberation into handheld devices and shows the potential in bringing multi-sided large-scale cyber-argumentation into the limited screen sizes platforms.


By an agreement of June 7,1920, the Government of the United States and the Reparation Commission submitted to a tribunal of three arbitrators the claim of the Standard Oil Com pany to beneficial ownership in certain tankers belonging to a German company at Hamburg and flying the German flag, which were turned over to the Reparation Commission by the German Government under the provisions of the Treaty of Versailles. The tribunal found that, except for an infinitesimal part, all the shares and debentures representing the capital of the German company were originally owned by the American company; that an attempted sale of its voting shares by the latter to a German national in February, 1917, when war was imminent between the two countries, was invalid because there had been no actual transfer of the shares in compliance with German law, and that therefore at the time of the coming into force of the Treaty of Versailles the American Com pany was still the owner of the wnole of the shares of the German company. By a majority decision, from which the American arbitrator dissented, the tribunal held that the ownership of the securities of the German company did not vest in the American company the beneficial ownership of the tankers, which it conceived to be a special kind of right distinct from the right of ownership of the securities and additional to it. It was held that neither the shareholders nor other creditors have any right to corporate assets other than to receive a share of the profits during the existence of the company and a proportional share of the assets after it is wound up; that the control of a corporation by certain share holders is not equivalent to ownership of its property; that the right of shareholders to the in come produced by the operation of the corporate assets does not make the shareholders beneficial owners of the said assets inasmuch as such profits belong to the shareholders only in so far as and when they are distributed; and that the right of sharing in the income when allotted, and in the division of assets when the company is dissolved, are so essentially the characteristic rights of shareholders that they cannot be held to constitute a distinct and added right of beneficial ownership in the corporate assets. The company's claim for equitable financial reimbursement was also disallowed by the majority award because of the attempted sale of the shares to a German national in 1917, which the tribunal set aside by the strict application of German law, thus enabling the Ameri can company to submit its claim to the tribunal only by the application of strictly legal considerations; and secondly, because an investor in a foreign country must submit to the laws of that country and assume the risks incident to a state of war, and has no ground for complaint if he receives the same treatment as nationals of the country and of allied and associated nationals with regard to their property therein as provided by the treaty of peace.


B lood pressure (BP) follows a circadian rhythm that typically peaks after waking and lowers during sleep. An absence of appropriate BP decline during sleep is referred to as nondipping (or reverse dipping if there is an antithetical increase in BP during sleep) and is associated with adverse cardiovascular outcomes.1 Based on these observations, trials were undertaken to evaluate the impact of a simple intervention aimed at altering the timing of administration of antihypertensive medications to bedtime dosing (so-called bedtime chronotherapy) on the nocturnal BP pattern, and more importantly, to assess the impact of bedtime chronotherapy on clinical outcomes. The large Hygia Chronotherapy Trial has been touted as the strongest source of evidence in support of this strategy. However, the evidence for bedtime dosing of antihypertensive medications, including the Hygia trial, is far from definitive and is limited by concerning flaws in design and reporting that challenge the interpretation of these findings and incorporation into practice. The focus of this article is to describe the results and implications of the Hygia trial in the context of physiological evidence and previously published and ongoing clinical trials evaluating bedtime dosing of antihypertensive medications. THE HYGIA CHRONOTHERAPY TRIAL


The utility model discloses a flexible flat cable with a stiffening plate coat structure, which comprises a conductor, a lower insulation coat attached to the lower surface of the conductor, a lower stiffening plate and an insulation-skin coat arranged at the position of the terminal copper wire of the flexible flat cable. The inner layer of the insulation-skin coat is attached to the conductor, and the stiffening plate is attached to the outer layer of the insulation-skin coat. The polyethylene terephthalate (PET) insulation-skin coat with a hot melt adhesive is attached between the stiffening plate and the position of the terminal copper wire of the flexible flat cable, the copper wire is attached to the surface of the hot melt adhesive of the PET insulation-skin coat, and the other surface of the PET insulation-skin coat is attached to the stiffening plate. The structure confirms to material properties so that adhesive strength of the position of the terminal copper wire of the flexible flat cable is improved, and the ill effect that the copper wire raises is avoided.


Excitement is growing around the world about the Internet's potential to enable a global electronic commerce. The reality, however, differs a great deal depending on what part of the world we consider. In Latin America, the e-commerce theme is often found in the popular press portraying it as a solution for multiple national problems and as a catalyst to propel the region to a stronger position in the world economy. Unfortunately, many of the "new" capabilities required to harness the economic benefit of e-commerce, which emphasize value-adding steps performed through and with information, are very scarce in the region. This article raises questions about Latin America's ability to exploit the Internet, and to implement and capitalize on e-commerce applications. It underscores the region's need to engage in a future planning discourse about the adoption of e-commerce within organizations, communities, and across traditional boundaries of competition and national borders. To start the dialogue, four scenarios are presented as "future snapshots" written from the vantage point of the year 2010. Each scenario considers issues regarding technological adoption and potential social responses, and discusses some of the critical assumptions about patterns observed in the region today and their implications for the future. © 2001 John Wiley & Sons, Inc.


European energy utilities face a range of policy induced challenges that are materially affecting their financial returns. Accordingly, in this paper we examine the impact of liberalization, energy efficiency, renewable energy, and security of supply legislation on European energy utilities' returns between 1996 and 2013. We implement an event study portfolio analysis using a comprehensive list of major regulatory changes, the largest utility sample to date, and a novel asset pricing model that controls for sector-level stock-market, term premium, and commodity risk factors. The results show EU policies that focus on liberalization and energy efficiency have a significant negative impact on the energy sector's financial returns. This reflects changes in the fundamental risk-reward trade-off of European energy utilities and investors' recognition of the economic impact of EU legislations on the sector. Contrary to assertions by the financial press, renewable energy objectives have no significant impact on returns at sector-level; the impact is mostly concentrated on the natural gas utilities. Our results highlight a tension between liberalization and environmental objectives, negatively impacting the sector's ability to raise the estimated $2.2 trillion investment capital needed to ensure reliable and increasingly environmentally-friendly energy supply.


Why did quality media lose peoples trust? Why is a big part of the audience listening more to lies and accusations than to well curated and fact based journalism?

By Jacob Mollerup, Danish editor and media consultant


In this paper, we establish the Lyapunov-type inequality for boundary value problems involving generalized Caputo fractional derivatives that unite the Caputo and Caputo-Hadamrad fractional derivatives. An application about the zeros of generalized types of Mittag-Leffler functions is given.


The factors that arouse interest in the study of essential oils as biocidal agents are numerous, such as the fact that they have antibacterial, antifungal, insecticidal, antioxidant, anti-inflammatory and larvicidal properties. The objective of this work was to evaluate the antimicrobial activity, in vitro, of the laurel (Laurus nobilis L) essential oil on the growth of pathogenic bacteria Salmonella enterica serovar Typhimurium ATCC 14028 and Staphylococcus aureus ATCC 25923, at different exposure times, as well as to perform the chemical characterization. Twenty compounds were identified and quantified, representing 96.57% of the total composition. The class of oxygenated monoterpenes represented the majority class of the essential oil, with 1,8-cineol (33.8%) as the substance found in greater quantity, followed by linalool (17.79%). The third constituent in greater quantity was sabinene (12.23%), belonging to the group of monoterpene hydrocarbons. Terpinyl acetate (9.41%) was also considered to be quantitatively representative. Laurel essential oil showed bacteriostatic activity against S. Typhimurium ATCC 14028 and S. aureus ATCC 25923.


We have developed easy to use fast multipole method (FMM) libraries for the Laplace, low-frequency Helmholtz, and Stokes equations in two and three dimensions. The codes are based on a new method for applying translation operators and provide reasonable performance on either single core processors, or small multi-core systems using OpenMP. AMS subject classifications: 52B10, 65D18, 68U05, 68U07


Fusion of 2-cell embryos generates tetraploid (4n) blastomeres with an increased commitment to trophectoderm. Complementation of embryos from endangered species with 4n blastomeres derived from a phylogenetically related domestic species could improve healthy pregnancy establishment after embryo transfer in domestic females. However, generation, development, and quality of tetraploid complemented embryos in felids remain unstudied. Therefore, our objectives were (1) to evaluate tetraploidy of 2-cell fused embryos; (2) to analyse the blastocyst cell number, distribution after synchronic (S) or asynchronic (AS) complementation, OCT4+ cells, DNA-fragmentation levels and CDX2 gene expression of IVF complemented embryos; and (3) to evaluate the developmental rates of tetraploid complemented Felis catus-Leopardus geoffroyi hybrid embryos. After ovariectomy, Felis catus oocytes were IVM and subjected to IVF. For Experiment 1 (n = 66), 2-cell embryos (2n) were exposed to two 30-ms DC pulses at 8 kV cm−1 electric field in fusion media. Fused (4n) and nonfused embryos were cultured in vitro in 50-μL drops of modified Tyrode's medium. Karyotype analysis was performed at Day 4. For Experiment 2 (n = 24), zona-free IVF embryos were aggregated S (4-cell-2n/4-cell-2n) or AS (4-cell-2n/2-cell-2n and 4-cell-2n/1-cell-4n). For Experiment 3 (n = 36), blastocysts generated by AS complementation (4-cell-2n/2-cell-2n and 4-cell-2n/1-cell-4n) were either fixed with 4% paraformaldehyde for immunofluorescence and terminal deoxynucleotidyl transferase dUTP nick end labeling assay or saved in RNA-Later for RT-qPCR analysis. For this experiment, nonaggregated 2n and 4n blastocysts were used as a control. For Experiment 4 (n = 60), IVM oocytes were co-incubated with Leopardus geoffroyi and Felis catus (control) spermatozoa and then 4-cell-2n heterologous embryos were complemented with 1-cell-4n homologous IVF embryos. Data were analysed by Fisher's exact test. Our results showed that 67% of the 2-cell fused embryos were 4n. Moreover, 82% of nonfused embryos were aneuploids compared with 78% of 2n embryos in the control group. The AS complemented blastocysts (4-cell-2n/1-cell-4n and 4-cell-2n/2-cell-2n) had significantly higher cell number compared with S complemented (4-cell-2n/4-cell-2n) or noncomplemented embryos. The AS complementation also increased the number of OCT4+ cells independently of the ploidy of the embryos. Interestingly, AS tetraploid complemented embryos had significantly lower number of cells with fragmented DNA. No differences were found in CDX2 expression among complemented embryos; however, noncomplemented 2n blastocysts showed a significantly lower expression compared with the others group. Finally, we observed that AS complementation of 2n hybrid embryos with 4n homologous embryos reached similar blastocyst rates, 70 and 88%, respectively. Our findings support the use of 2-cell fused embryos to generate 4n blastomeres and demonstrated that tetraploid complementation generates good quality embryos, providing evidences that encourage the use of this technology to improve the developmental competence of interspecific embryos after transfer.


Spiral concentrators are gravity separators usually separating particle sizes between 0.1 and 2 mm in a water carrier medium1,2. The capacities of the spiral concentrators range between 1 and 3 t/h dry solids and recently in excess of 7 t/h in the case of high capacity spiral concentrators when treating typical heavy mineral beach sands deposits3. The spiral concentrators are usually configured in 5 to 7 turns and can accommodate up to four starts per column. Spiral concentrators have been part of the minerals processing industry for the past 50 years4. The technology is fairly simple, relatively inexpensive and well established for pre-concentration application in mineral sands and coal industries for treating fine ore. Developments over the years include; improved feed box and splitter designs, trough design, wash water addition, capacity improvements, re-pulpers and product boxes1. Some disadvantages of spiral concentrators are: low throughput per unit (requiring large banks of spiral concentrators and large footprint, resulting in high capital processing plants); operation difficulties (especially cleaning the troughs and setting the splitters); sensitivity to feed fluctuations (the splitters need to be adjusted as feed conditions change); and large recycles due to inefficiencies. Recent trends are looking at high capacity units and automated splitter adjustments.5,6 As heavy mineral producers move into treating more difficult-to-treat low grade ores, concentrator plant capital cost and separation efficiencies become critical to the viability of processing the mineral deposit. Multistage processing and high recirculation loads are required to maintain high mineral recoveries of above 90% at mineral grades usually above 90%—typically 4 to 5 stages being the norm for the Exxaro and Richards Bay Minerals operations3. Concentrator plants are usually sized to a predetermined output and grade of mineral concentrate. Thus, the feed grade, determines the size of concentrator plants Traditional spiral concentrators such as the MG4 can operate in the range of 1.6 to 2.6 t/h (solids) at 35% solids by mass in slurry feed. In contrast high capacity spiral concentrators (HC) can operate between 4 and 7 t/h at similar feed densities (% solids)3,6. Four MG4 spiral concentrators have a footprint of approximately 1.5 m x 1.5 m whereas four HC Case study: high capacity spiral concentrators


EFFECTS OF INFORMATION ABOUT LEARNING DISABILITIES FOR LEARNING DISABLED ADULTS SEPTEMBER 1992 DENISE KERNAN, B.A., KEAN COLLEGE M.A., COLLEGE OF ST. JOSEPH THE PROVIDER ED.D., UNIVERSITY OF MASSACHUSETTS Directed by: Professor Patricia Gillespie-Silver The present study investigated the influence of cognitive training providing information about learning disabilities on two measures of achievement-related behaviors: the self-concept and comprehension of learning disabilities for five adjudicated learning-disabled adolescent delinquents. The subjects were four male African Americans and one Spanish American male ages thirteen through sixteen, who were incarcerated in a Department of Youth Services secure facility in Western Massachusetts. The study used a single-subject ABA design, and training was provided individually to subjects over the course of ten daily sessions. The training was based upon a text (Student Response booklet) developed by the experimenter. The subjects' task persistence was measured using daily observation in mathematics classes. Subject productivity was measured using a daily tally of the number of math problems attempted. Measures of the subjects' self-concept were obtained using a pre/posttest measure of the Coopersraith Self-Esteem Inventory; measures of knowledge of learning disabilities were obtained using Pre/posttest


The purpose of this paper is to build up a two-dimensional analysis framework to analyze the spatial variation of urban housing prices from the viewpoint of hedonic price,and then verify the framework through an empirical study on housing market of Hangzhou City.Methods of literature consultation and econometric analysis were employed.The results indicate that the spatial variation of housing prices is due to the variation of impacts of housing characteristics on the different prices and on the unbalanced spatial distribution.It is concluded that the analysis framework based on hedonic price model is effective and feasible.


The present invention provides a solid preparation of repaglinide liposome preparation method, by selecting a specific weight ratio of repaglinide, egg yolk lecithin, soy sterol dilauroyl phosphatidylglycerol, made of superior quality repaglinide liposomes, liposomes then repaglinide general method for solid preparation formulation. Compared with the prior formulations, the formulations of the present invention dramatically improves the stability, bioavailability of the formulation, improved product quality and sustained release formulations, reducing the side effects.


Electrochemically initiated copolymerization of calcium acrylate and methacrylate with methacrylic acid was studied. The reaction was conducted on graphite electrodes in aqueous sodium chloride solutions. It was shown that the copolymer can be obtained under these conditions with a 45-48% yield. The influence of the current density, the amount of electric charge passed, and the polymerization time on the yield of copolymer was studied.


Research on the phytostabilization of mercury in Ipomoea reptans Poir plants has been done. This study aims to determine the effect of planting age on the ability of mercury uptake by leaves of Ipomoea reptans Poir, knowing the mercury concentrations distributed on the leaves of Ipomoea reptans Poir and determine the ability of Ipomoea reptans Poir plants as mercury hyperaccumulators. Planting age used in this study consisted of four times, namely: 2, 3, 4 and 5 weeks. The concentration of planting media used is 25 ppm, 50 ppm, 75 ppm and 100 ppm. The results of the analysis showed that the maximum absorption time occurred in the third week with absorption concentrations of 145.484 μg / gr dry weight, and that value was an indicator that Ipomoea reptans Poir was a mercury hyperaccumulator.


With the refinement development trendency of China's logistics industry,the construction of logistics management curriculum system and the reforment teaching in secondary vocational schools are becoming new problems. Based on the Shanghai regional economic background,combined with reform practice of the logistics management major(chemical logistics) curriculum system in Shanghai Petrochemical Academy,this thesis explored the construction ways of the chemical logistics curriculum system.


1. Elliptic Anomaly in the Two-Body Problem 2. Elliptic Anomaly in Perturbed Motion 3. Linear Theory of Motion for Highly Eccentric Artificial Satellites 4. Theory of Motion of Asteroids in Highly Eccentric (Non-Intersecting) Orbits 5. Theory of Motion of the Objects in Orbits Intersecting in Projection 6. Computational Formulas


Changes in consumer's desires in the recent past, have led to the requirement for more convenient foods having supreme qualities and freshness, minimally processed and packaged, easy to consume and nutritionally healthier. Hence, the focus of food scientists and engineers have been directed towards alternative technologies or minimal processing and preservation technologies that are environment friendly, low in cost and able to preserve fresh quality attributes of the food. Many novel non thermal technologies like high pressure processing, pulsed light, pulsed electric field, ultrasound, irradiation etc. find application in preservation of food and is in the line of commercialization.


Customer value co-creation nowadays is critical for marketing success. However, many firm-initiated co-creation activities face difficulties in attracting and activating promising community members. Based on self-determination theory, we developed a research model to understand the customers' motivation to voluntarily engage in value co-creation behaviors from the perspective of brand community engagement. An online survey on brand communities were employed to test the hypotheses derived from the research model. Partial Least Square Regression Analysis (PLS) approach is used to validate the measures and test hypotheses. Results indicated that highly-engaged customers tend to participate in co-creation activities and customer citizenship behaviors. In addition, feelings of brand community engagement are enhanced by customers' brand-self connection and perceived relatedness. And perceived relatedness is most important in predicting brand community engagement among the four antecedents. We draw on these findings to offer implications for researchers and practitioners.


Diaphragmatic impairments exhibit high morbidity as well as mortality while current treatment options remain unsatisfactory. Tissue engineering (TE) approaches have explored the generation of an optimal biocompatible scaffold for diaphragmatic repair through tissue decellularization or de novo construction, with or without the addition of cells. The authors conducted a systematic review on the current state of the art in diaphragmatic tissue engineering (DTE) and found 24 articles eligible for final synthesis. The included approaches studied decellularization‐based graft generation (9) and de novo bioscaffold construction (9). Three studies focused on in vitro host‐scaffold interaction with synthesized, recellularized grafts (2) and decellularized extracellular matrix scaffolds (1). Another three studies investigated evaluation tools for decellularization efficacy. Among all studies, recellularization is performed in both decellularization‐based (4) and de novo generated scaffolds (4). De novo constructed biocomposites as well as decellularized and recellularized scaffolds induced pro‐regenerative remodeling and recovery of diaphragmatic function in all examined animal models. Potential therapeutic applications comprise substance defects requiring patch repair, such as congenital diaphragmatic hernia, and functional diseases demanding an entire organ transplant, like muscular dystrophies or dysfunction after prolonged artificial respiration.


The utility model relates to a high-efficiency wind power generation device, which is composed of a wind collecting cylinder, a central cylinder, a diffusing cylinder, an impeller, a generator, a reinforcing steel belt, a concave frame, a small support, a wedge-shaped cushion block, a yaw platform, a large gear ring, a small gear, a speed reducer, a yaw motor, a wind-direction detector, an idler wheel, a central shaft, a large platform, a large support and a control box. The high-efficiency wind power generation device can achieve the effects of miniaturized large installed capacity, low investment and high benefit. A wind collecting device can speed up the weaker wind of the earth surface, and the high-efficiency wind power generation device can be built in low altitude, so that the cost is greatly reduced. A yaw mechanism can cause the wind collecting device to track the change of wind direction at any time to be toward the best wind direction. The windward side of the impeller of a vertical axis wind turbine enters into the central cylinder, the against-wind side is at the outer surface of the central cylinder, the low-speed wind speeded up by the wind collecting cylinder enters into the central cylinder to push the impeller of the windward side to rotate, and the positive moment is greatly increased. The wind power is reduced when the wind collecting cylinder is blocked out, so that the negative moment is greatly reduced, and the generating efficiency is increased.


The objective of this research is to analyze the multistoried RC building on a sloping ground with different angles. In this research of multistoried RC G+10 building with different sloping angles (25˚, 26˚, 27˚, 28˚, 29˚, 30˚). We have determine the results on this G+10 structure without slope and angles having plane ground. For this analysis two types of condition taken for the study along sloping ground i.e. set back and step back. The results compare from this analysis are storey drift, node displacement, base shear.


Abstract : There is a growing sense of community in East Asia. This represents a reaction to a history of great power domination, increasing globalization, and economic integration. With its vast market potential and production capacity, China has made decisions favoring market-driven liberalization while it emerges as a growing economic and political power. Suspicions are naturally raised regarding its ultimate intentions -- partnership in the global community or regional hegemony. The United States has not been actively engaged in the significant changes taking place in East Asia, relying instead on bilateral security arrangements while pursuing more immediate interests in the war on terror. Facing the growing influence of China and India, political leaders within East Asia have cautiously developed various multilateral forums for responding to regional issues. The ASEAN-led East Asia Summit of December 2005 was an overt first step toward the notion of an East Asian Community led by small powers. While a true regional community similar to the European Community remains somewhat distant and uncertain, the United States must become more involved in regional diplomacy or risk losing influence there. Meanwhile, contemporary changes in East Asia appear to make realization of an East Asian Community a distinct possibility.


Abstract:  Thermoelastic stress analysis (TSA) is applied to a helicopter titanium tail rotor hub component with complex geometry and subjected to multiaxial loads. The frequency of the loads adopted in the TSA test was 2 Hz because of the fact that hydraulic actuators were used. As a consequence, non‐adiabatic conditions were met in some parts of the component and a correction applied to the raw data obtained by TSA. The reliability of the corrected TSA data was checked by comparing the data with the results of a finite element model, validated previously by strain gauge measures. The good agreement between the experimental and the numerical data shows that TSA can be successfully used for structural components with complex geometry and subjected to multiaxial loads under non‐adiabatic conditions.


Child welfare is undergoing dramatic changes in how social services agencies work with children and families. Contra Costa County is one of 11 Cohort One counties, also known as early implementers, of the states' Redesign efforts. The emphasis of the Redesign is to improve outcomes for children and families. The Redesign states that in order to improve outcomes for children that the voice of the child must be heard and that the community needs to be engaged.


The metallothionein active site in vacuo was studied using ab initio methods as a necessary step in order to understand the relationship between the structure and the efficiency of the protein in binding cadmium ions. The natural Cd4Cys11 cluster located in the protein α-domain was represented by cadmium–thiolate complexes. First, it was shown, by comparison with available experimental results, that the geometry and the binding energy of cadmium coordination complexes can be correctly predicted at the RHF-MP2 theory level using the effective core potentials (ECP) and the double-ζ basis sets of Hay–Wadt, improved with polarization and diffuse functions. The computed geometry of the model system of the α-domain active site was then compared with that extracted from the X-ray crystal structure of the metallothionein. The significant difference between the two structures was attributed to the external constraints imposed in the natural cluster by the surrounding protein structure. The nature of the Cd–thiolate bond was further examined by calculating natural atomic populations and localizing the molecular orbitals. A good correlation between the Cd–S bond length and the amount of charge transferred from the ligand to the cadmium ion was found allowing an explanation of the effects of ligand protonation on the structure of mixed cadmium–thiol/thiolate complexes.


The issue of fundamental nature of works is the question of neighboring category concept of the works.None of the intellectual achievements,expressing modes or expression is the fundamental nature and neighboring category concept.The expressing object refers to the organic combination of symbols, the material of which is language,words,lines,colors,and the mode of which is mutual relations between those symbols.The fundamental nature of works is the designed program of expressing object,as well as the combining program of symbols.


Objective To evaluate the efficacy of the treatment for refractorychronic bacterial prostatitis with intraprostatic injection. Methods 278 cases of refractorychronic bacterial prostatitis received bacteria cultivation of prostate fluid and drug sensitivity tests. They were treated with intraprostatic injection of mixed liquid of 1 or 2 sensitive antibiotics and other drugs. Results Among 278 cases 86 were cured, 147 had improvement, 45 were ineffective, the total efficiency rate was 83.8%. Conclusion Intraprostatic injection is effective for the treatment of refractorychronic bacterial prostatitis.


Quantum bases of consciousness and free will are considered with implications of two cognitive modes of consciousness (direct religious/creative, characteristic of quantum-coherent transitional and altered states of consciousness, and indirect perceptually/rationally mediated, characteristic of classically-reduced normal states of consciousness), as well as conditions of transformations of one mode into another, and related psycholinguistic and psychotherapeutic implications by applying theoretical concepts of associative neural networks and quantum neural holography combined with quantum decoherence theory.


Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign but potentially disfiguring vascular proliferation. It is most common in women during the third to fourth decade. The cause of ALHE is unknown, although trauma and reactive hyperplastic processes have been proposed. Angiolymphoid hyperplasia with eosinophilia is often associated with spontaneous bleeding, pain, growth, pulsation, and pruritus. Multiple treatment options have been reported for ALHE, and we report a case of ALHE responsive to sclerotherapy.


Low Medicaid pay forces some Children's Health Pediatric Group clinics in Dallas to close, others turn to midlevels to cut costs, raising quality concerns.


We present a hierarchical classification model that allows rare objects to borrow statistical strength from related objects that have many training examples. Unlike many of the existing object detection and recognition systems that treat different classes as unrelated entities, our model learns both a hierarchy for sharing visual appearance across 200 object categories and hierarchical parameters. Our experimental results on the challenging object localization and detection task demonstrate that the proposed model substantially improves the accuracy of the standard single object detectors that ignore hierarchical structure altogether.


Awareness of the importance of sustainable agriculture has increased in recent decades. One of the reasons for this is the widespread use of synthetic pesticides and their possible secondary negative effects on valuable carnivores and biodiversity. Therefore, the need for biological and environmentally friendly alternatives to pest control has become relevant. This relevance is also reinforced by the European Union's Green Deal agenda and its underlying strategy - Farm to Fork, which aim to mitigate climate change, prevent biodiversity loss and feed Europeans healthily. This study aims to assess the attitude of the Latvian society, in particular specific stakeholder�s groups playing important role in food systems, towards the achievement of the goals set in the European Union�s Green Deal agenda regarding the reduction of pesticide use and the search for alternative ways of protecting harvests from pests and diseases. There are several important signals arising from the results of this study and timely response to them can help policy makers, scientists, consultants and practitioners to contribute in reaching EU Green Deal goals, to redesigning existing food systems and to promote greater use of safe alternative ways of protecting harvests from pests.


The relationship between negative self-perception and epilepsy has been addressed in a number of studies but little is known about any association between perceived acceptance by others and various factors relating to epilepsy. The aim of this study was to investigate if perceived acceptance correlates with perceived stigma, perceived severity and a variety of factors associated with epilepsy. 52 individuals with a diagnosis of epilepsy attending an outpatient clinic participated in the study. Participants completed questionnaires measuring aspects of epilepsy as well as perception of stigma, severity and acceptance by others. Results showed that type of epilepsy was significantly correlated with perception of stigma. Significant negative correlations were found between perceived stigma and perceived acceptance and between duration of epilepsy and perceived acceptance. It was concluded that perception of acceptance is related to the way in which the individual learned to cope with the diagnosis of epilepsy.


A new family of three-dimensional Newtonian models for galaxies is constructed. The models describe a thin disk and a matter halo, whose gravitational potentials satisfies the equation (2) presented in Gonzalez & Pimentel (2016, Phys. Rev. D, 93, 044034), and therefore, they satisfy the energy conditions for a gravitational system. The expressions for the potential of the disk and the halo are obtained by applying the "displace, cut, and reflect" method to the solution of the Laplace equation in cylindrical coordinates. Analytical expressions that describe the rotation curves and the mass distributions in the disk and in the halo are computed for the first three models of the family of solutions. It is shown that the mass densities of the disks and the haloes present a maximum at the center of the system and go to zero at infinity. Finally, for some values of the free parameters, the obtained rotation curves present a flat region for larger values of the radial coordinate. The model was obtained considering the total gravitational potential, which satisfies the equation (2) imposed by Gonzalez & Pimentel (2016). The potential generated by the spheroidal halo of matter is constructed considering a multipolar expansion, expressed in cylindrical coordinates. As this solution of the Laplace equation a substitution is done so that the Laplacian is nonzero, the z coordinate (Kuzmin, 1956, AZh, 33; Toomre, 1963, ApJ, 138, 385). So the new potential satisfies Poisson equation and represents the distribution of three-dimensional material. From the gravitational potential analytical expressions were derived for the surface density of the disk, halo density of matter and from the rotation was derived. We found that the surface densities of the disks present a maximum at the center, vanishing at infinity; and the halo density is maximum at the disk surface, also vanishing at infinity. For some values of the parameters, the derived rotation curves present a flat region for larger values of the radial coordinate.


The objective is to provide a sensor that uses non-contact, laser ultrasonics to measure the stiffness of paper during the manufacturing process. This will allow the manufacturer to adjust the production process in real time, increase filler content, modify fiber refining and as result produce a quality product using less energy. The sensor operates by moving back and forth across the paper web, at pre-selected locations firing a laser at the sheet, measuring the out-of-plane velocity of the sheet then using that measurement to calculate sheet stiffness.


Chapter 1. The Form of News: Style, Production, and Social Meaning, 1750-2000 Part I. Before Modernism Chapter 2. The Founding Forms: Politics and the Work of Newspapers, 1750-1850 Chapter 3. Commercialization: The Newspaper and the Market Revolution, 1780s-1880s Part II. The Role of Pictures Chapter 4. Civic Picturing: The Regime of Illustrated News, 1856-1901 Chapter 5. The President Is Dead: Pictures and Journalistic Values, 1881-1963 Part III. The Rise of Modernism Chapter 6. The Front Page: Measuring Modernism and Its Phases, 1885-1985 Chapter 7. Visual Mapping: Modern Design and Cultural Authority, 1920-1940 Part IV. After Modernism Chapter 8. Beyond Modernism: Americanization and Its Consequences, 1910-2000 Chapter 9. Spectators and Their Spectacles: Forms of Knowledge, Forms of Power References Index


Abstract : As the measurements desired by oceanographers and acousticians have become increasingly refined, the need to accurately design to experimental requirements the mooring systems used as instrumentation platforms has increased correspondingly. In this paper, some new approximation techniques that promise to result in more accurate mooring system designs than are presently possible are developed. These techniques deal with two topics in mooring dynamics. The first topic concerns the effects of flow-induced strumming vibrations on the static configuration of mooring systems that have one or more horizontal legs. The second topic concerns the dynamic response to time varying ocean current of taut, single point moors.


Traditional wireless sensors with bulky batteries require battery replacement or wireless charging which are not suitable for in vivo applications. Also, the leakage of battery chemicals is highly risky. Battery-free sensors are relatively small and easy to maintain. In this paper, the magnetic induction-based Near-Field Communication (NFC) is employed to charge and communicate with intra-body sensors. Cell phones with NFC modules can be leveraged as readers to interact with in vivo sensors. In this way, the system does not require additional external wireless devices. The collected health-related data can be processed by cell phones directly. The in vivo sensors are powered up by using magnetic induction-based wireless energy transfer and health-related data are transmitted by sensors using backscatter communications. This paper introduces the system architecture and associated wireless simulations and empirical results. The inhomogeneous human body is considered using a layered-media model. Electromagnetic simulations are performed in COMSOL Multiphysics to study the communication range with signals from 100 kHz to 100 MHz in various environments. The results provide guidelines on the design of in-vivo battery-free sensors in terms of power consumption, coil size, and implanted depth.


A compilation of the major educational experiences supported by information Technology and Communication (ICT) that have taken place in the Regional Multidisciplinary Faculty Carazo (FAREM-Carazo) of the National Autonomous University of Nicaragua, Managua (UNAN-Managua), emphasizing the use of Moodle, video projects and training courses in ICT. The work is an effort to rescue the legacy that FAREM-Carazo has built one of the powers of the UNAN-Managua, pioneer in the management of ICT-mediated knowledge, their contribution to the expansion and enhancement of the educational horizon of their students, helping to diminish the digital divide in Nicaragua and promote an inclusive social education. The methodology used was basically the review and documentary analysis of reports written by teachers in the FAREM-Carazo, who have been key elements in terms of integration and development of ICT in this power. Notably, these memories include the planing, implementation, monitoring, evaluation and projections of each of the ICT experiences addressed.


AIM: To observe the effects of angiotensin Ⅱ (AngⅡ) on potassium currents of human atrial myocytes so as to reveal the mechanisms of atrial arrhythmia induced by AngⅡ, and to provide a laboratory basis for the application of angiotensin Ⅱ receptor antagonist in the treatment of atrial arrhythmias. METHODS: Single human atrial myocyte was isolated and the conventional whole-cell configuration of patch-clamp technique was used to detect membrane I k1 and I to. The experiment was conducted in four groups: control group, AngⅡ group, telmisartan group, and AngⅡ + telmisartan group. RESULTS: Compared with the control group, AngⅡ of 0.1 μmol/L significantly decreased the peak density of I to in human atrial myocytes (pA/pF,6.55±0.52 vs 12.65±1.06 , P0.01). Under the voltage of -100 mV, AngⅡ significantly increased the peak density of IK1 (pA/pF, -9.31±1.02 vs -5.23±0.98 , P0.01). Telmisartan of 0.01 μmol/L had no significant effect on I k1 and I to in human atrial myocytes, but it antagonized the effects of AngⅡ. In AngⅡ + telmisartan group, the peak density of I to (pA/pF, 11.74±1.28) and the peak density of I K1 ( pA/pF, -6.13±1.15) were both significantly different with those in AngⅡ group(P 0.01). CONCLUSION: AngⅡ has significant electrophysiological effects on human atrial myocytes. AngⅡ of 0.1 μmol/L significantly increases the peak density of I K1, but decreases the peak density of I to in human atrial myocytes. Telmisartan antagonizes the effects of AngⅡ on human atrial myocytes.


The HERO project aims to develop a training program for caregivers to be
 working in the elderly care sector. The program is particularly addressed to
 caregivers from Middle Eastern and African countries as refugees and intends
 to help them integrate into European society. This paper seeks to offer an
 overview of the project, including its objectives, underlying principles,
 and deliverables. The paper particularly portrays the second intellectual
 output (O2) of the project, namely the 'On the job' training in language and
 terminology curriculum, which has been developed as the end product of O2.
 Initially, the methodology adopted to create learning material for language
 learning in a specific-purpose context is analyzed. Based on this, the paper
 provides a description of the content development by justifying and
 showcasing the learning material and laying out the logic behind this,
 through the trainers' guide. E-learning tools have been integrated in the
 course material, which also justifies the methodology applied for the
 purpose of this project.


Background— Aortic valve bypass (AVB; apicoaortic conduit) surgery relieves aortic stenosis (AS) by shunting blood from the apex of the left ventricle to the descending thoracic aorta through a valved conduit. We have performed AVB surgery as an alternative to conventional aortic valve replacement for high-risk AS patients. Methods and Results— Between 2003 and 2007, 31 high-risk AS patients were treated with AVB surgery. Twenty-two patients (71%) were undergoing reoperation with patent coronary bypass grafts, and 5 (16%) had a porcelain ascending aorta. The average age was 81 years. Cardiopulmonary bypass was used for 19 of 31 patients (61%); the median duration of cardiopulmonary bypass was 19 minutes. Cross-clamp time for all patients was 0 minutes. Perioperative mortality was 13% (4 of 31 patients); no perioperative deaths occurred in the last 16 consecutive patients. One patient experienced a stroke related to intraoperative hypotension. No strokes have occurred during follow-up. Renal function was unchanged after AVB (preoperative creatinine, 1.3±0.5 mg/dL; postoperative creatinine, 1.2±0.5 mg/dL). The mean gradient across the native aortic valve decreased from 43.5±15 to 10.4±5.4 mm Hg. Echocardiographically determined conduit flow expressed as a percentage of total cardiac output was 72±12%. Conclusions— AVB surgery is an important therapeutic option for high-risk patients with symptomatic AS. Ventricular outflow is distributed in a predictable fashion between the conduit and the left ventricular outflow tract, and AVB surgery reliably relieves AS. Stroke and renal dysfunction were uncommon.


The cyberinfrastructure supporting science appears will include large-scale simulation systems headed to exascale combined with cloud like systems supporting data intensive and high throughput computing, pleasingly parallel jobs and the long tail of science. Clouds offer economies of scale, elasticity supporting real time and interactive use and powerful new programming models such as MapReduce. We stress that iterative extensions of MapReduce will be necessary to get good performance on for several data mining (analytics) applications. We give several illustrations mainly from bioinformatics. We suggest that the data deluge implies a corresponding increase in the computational resources needed to support analysis and this suggests new architectures for large scale data repositories.


The texture distribution, tensile property and fracture toughness of 7050 aluminum alloy thick plate were investigated by optical microscopy, scanning electron microscopy, transmission electron microscopy, X-ray diffractometry, tensile and toughness tests. The results show that the microstructure,texture,tensile property and fracture toughness are inhomogeneous in different layers along the thickness direction. At the same thickness, the tensile property and fracture toughness show appreciable anisotropy. From the surface to the center, the average sizes of the coarse second phase particles and recrystallization grains increase. Near the surface of the plate,typical shear textures {111}110 and cube textures {001}100 are observed, while the center of the plate shows typical β fiber texture with a scattering of cube texture. The quarter layer of the plate seems to serve as a transition layer. From the surface to the center, the strength is inhomogeneous in the rolling direction and long transverse direction. The strength in the center is smaller than that on the surface of the plate. The strength and fracture toughness show appreciable anisotropy at the same thickness. The strength in the rolling direction is higher than that in the long transverse direction and the short transverse direction, and the fracture toughness in the L-T orientation is higher than that in the T-L and S-L orientations at the same thickness. The fracture mode in the L-T orientation is trangranular fracture, and in the S-L orientation the fracture mode is intergranular fracture. In the T-L orientation, the fracture mode is a mixed fracture, the fraction of the trangranular fracture is lower than that in the L-T orientation, and the fraction of the intergranular fracture is lower than that in the S-L orientation.


Introduction: To analyze how the histomorphological features of adenocarcinoma lesions are related to the survival of patients, we developed a deep learning based pancreatic adenocarcinoma survival model that predicts death risk through the general adenocarcinoma feature extractor (GAFE). Our pancreatic adenocarcinoma survival model and GAFE was trained with hematoxylin and eosin (H&E) stained whole slide images (WSIs). Also, to measure the generalization performance, we predict the death risk of rectum adenocarcinoma and breast adenocarcinoma using the pancreatic adenocarcinoma survival model.
 Design: The whole data analyzed in this study was from The Cancer Genome Atlas (TCGA). We used a self-supervised contrastive learning method to train GAFE with randomly chosen 328 adenocarcinoma H&E stained WSIs. These WSIs are consisted of 92 lung (TCGA-LUAD), 100 colon (TCGA-COAD), 97 prostate (TCGA-PRAD) and 39 stomach (TCGA-STAD) adenocarcinoma WSIs. For the pancreatic adenocarcinoma survival model, we used 179 WSIs of TCGA pancreatic adenocarcinoma (TCGA-PAAD) dataset labeled with survival events and periods. There existed 66 uncensored data, and we used 5-fold cross validation. Each WSI was divided into 256*256 pixel-wise patches. Feature vectors were extracted from the patches using the GAFE. Then the attention-based multi-instance learning was applied to train the survival model. The trained model returned a death risk for each patient. We used 122 adenocarcinoma H&E stained WSIs of rectum (TCGA-READ) and 999 of breast (TCGA-BRCA) from TCGA to test the generalization performance for different organs.
 Result: We used 5-fold cross validation for testing the pancreatic adenocarcinoma survival model. The mean value of C-index from the TCGA-PAAD test datasets was 0.7258 where the highest and the lowest C-index was 0.7784 and 0.6598. Using the model with median performance (C-index: 0.7216), we measured death risk and divided patients into 50% of high-risk and 50% of low-risk groups. From this, the p-value was 0.01986 for the log-rank test.To analyze the performance of the generalization, we ensembled 5 models from the above. We tested our ensembled model on TCGA-READ and TCGA-BRCA. The C-index for TCGA-Read was 0.6941 where the C-index for TCGA-BRCA was 0.5711.
 Conclusion: We found that adenocarcinoma's histomorphological features had some correlation with pancreatic adenocarcinoma survival prediction. Moreover, we could see the possibility of transferability of adenocarcinoma histomorphological knowledge and survival analysis to other organs such as rectum adenocarcinoma and breast adenocarcinoma.
 Citation Format: Joonho Lee, Geongyu Lee, Tae-Yeong Kwak, Sun Woo Kim, Hyeyoon Chang. A deep learning based pancreatic adenocarcinoma survival prediction model applicable to adenocarcinoma of other organs [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5060.


The article reveals the importance of historicism elements in mathematics lessons in elementary grades. The author demonstrates opportunities to increase students 'interest in learning mathematics and in-depth study of the facts being studied.


Competitiveness of the students is increasing. Students with better skills are graduating from universities all over the world. More and more efforts are being done to improve the skills of the undergraduate students. In the Faculty of Engineering of the National Autonomous University of Mexico (UNAM) many lecturers use projects to help students to better understand the concepts and to improve their teamwork skills. However many of these efforts are isolated and have been done in an empirical way. The Manufacturing and Design Center is seeking ways to get students with better skills and bring together the isolated efforts done by many lecturers. Therefore a new technique is being explored for the mechanical design area. This technique is based on the Project Based Learning method. Two main approaches are being explored: the Horizontal Projects (HP) and the Vertical Projects (VP). The basic idea for the HP is to have a Great Design Team (GDT) developing a project in one semester. Students from different subjects of the Mechanical Engineering program compose the GDT. Each of these groups have access to information related to the subject they are attending in a central database. Students work on the different issues according to their subject; e.g. Mechanics of Solids solve issues related to the stress in the different elements of the machine or product developed; the Product Design subject works on the definition of the product specifications, requirements etcetera. Periodical meetings help to evaluate the global progress of the GDT. In the VP one student works on different stages of the project as he/she moves from one semester to the next, all the time working in the same project. The expected benefit of this technique is to provide the student with a better view of the different stages involved in the development of a project. Both techniques are being explored. Each of these techniques has advantages and disadvantages. This paper describes in detail these techniques and the potential applications for other careers within the Faculty of Engineering.Copyright © 2005 by ASME


A consecutive series of 10 typical and 4 partial cases of Wallenberg's syndrome is presented. The most prominent symptoms in these patients were found to be imbalance and various complex visual disturbances showing a rather distinct pattern characterized by tilt of the surroundings, oblique diplopia, difficulties of fixation and visual blurring. LateropuIsion was in all cases more or less clearly directed towards the side of the infarction. Imbalance, lateropulsion and visual disturbances as a rule improved rapidly but persisting disability was due to these features.


Predictors of functional capacities and skills in 143 soccer players aged 11–14 years from five clubs in Portugal were investigated. Data for players aged 11–12 (n=75) and 13–14 (n=68) years included chronological age, skeletal age, stage of pubic hair (PH), anthropometry, four functional capacities, four soccer skills and experience; composite functional and skill scores were derived. Multiple linear regression analysis was used to examine the independent effects of age, maturity, body size and proportions, adiposity and experience on individual functional capacities and skills and composite scores. Explained variances differed among functional capacities (22–48%) and skills (<25%), and were greater for composite functional (younger 37%, older 58%) than skill (younger 26%, older 18%) scores. Skeletal maturity was a predictor of the counter‐movement jump in both groups and of composite functional and skill scores in older players. Age and adiposity were primary predictors in players aged 11–12 years, while experience and a proportionally longer trunk (conversely, relatively shorter lower extremities) appeared among predictors in players aged 13–14 years. PH was not among predictors. Except for the counter‐movement jump, predictors of functional capacities and soccer skills differed between age groups.


Under similar reservoir sandbodies and fault conduit systems, the sandstone reservoirs in the middle Es3 member of the Niuzhuang Sag have been problematic for a long time. The following problems remain unsolved:  The distribution of sandstone porosity is inconsistent with the hydrocarbon accumulation. The oil sandstones have low porosity instead of high porosity.  Sandstones, which have the same properties, have different levels of oiliness, and the sandstones with almost the same properties show different degrees of oil-bearing capacity. This study analyzes the condition of reservoirs in the research area during the accumulation period in terms of paleoporosity recovery and discusses the critical porosity of the sandstone reservoirs during the same period. The following conclusions can be drawn from the results.  Although reservoir properties are low at present and some reservoirs have become tight, the paleoporosity ranging from 18% to 25% is greater than the critical porosity of 13.9%. As the loss of porosity is different in terms of burial history, the present porosity cannot reflect porosity during the accumulation period. Similarly, high porosity during the accumulation period does not indicate that present porosity is high.  The present reservoir location is consistent with the distribution of high paleoporosity during the accumulation period. This result indicates that high porosity belts are prone to hydrocarbon accumulation because of the dominant migration pathways generated because of property discrepancy under similar fault conduit conditions. Consequently, hydrocarbons mainly accumulate in the high porosity belts. Paleoporosity during the accumulation period is found to be a vital controlling factor. Therefore, high paleoporosity sandstones in the middle Es3 member of the Niuzhuang Sag have great potential for future exploration. Paleoporosity and critical property in the accumulation period and their impacts on hydrocarbon accumulation—A case study of the middle Es3 member of the Paleogene formation in Niuzhuang Sag, Dongying Depression, Southeastern Bohai Bay Basin, East China Liu Mingjie; Liu Zhen; Sun Xiaoming; Wang Biao; Zhang Wang; Yao Xing College of Geosciences, China University of Petroleum (email@example.com) 2.Geologic setting Several problems have remained unsolved for a long time in the middle Es3 member of the Niuzhuang Sag: The distribution of sandstone porosity is inconsistent with the hydrocarbon accumulation. The oil sandstones have low porosity instead of high porosity. Sandstones, which have the same properties, have different levels of oiliness, and the sandstones with almost the same properties show different degrees of oil-bearing capacity. The Niuzhuang Sag, which is located southeast of the Dongying Depression, covers an area of 600 km2 that extends from east to west. This sag has simple tectonic features that are composed primarily of synclines. Few faults exist in this area, except at the boundaries of the rift basin(Fig 1). This study mainly focuses on the western part of the Niuzhuang Sag and the middle Es3 member. When the target stratum was deposited, tectonic movement was strong, and the basin diminished rapidly. Therefore, large amounts of detrital materials were transported into the basin and formed the sedimentary facies of the delta and turbidite fans (Fig 2) Fig.2 Schematic Cenozoic-Quaternary stratigraphy of the Niuzhuang Sag, showing tectonic evolution stages and the major petroleum system elements. Fig.1 (A) Location map showing its six major subbasins of the Bohai Bay Basin. (B) Oil field distribution, the locations of sections DE and FG, well and normal faults for the top of Es3 interval in the study area. (C) Cross section DE showing the different tectonicstructural zones and key stratigraphic intervals. 1.Introduction AAPG 2014 Annual Convention


Two identity-based designated verifier signature schemes,which were proposed by Zhang and Li-Zheng-Zhu respectively,were analyzed.It was shown that two schemes did not satisfy the security requirements of designated verifier signature.Zhang's scheme did not meet the unforgeability requirement;Li-Zheng-Zhu's scheme did not have designated verification as although the non-designated-verifier could check the validity of the signatures.Then the schemes were improved.The improved Zhang's scheme owns unforgeability property,and has the same efficiency as the Zhang's.The improved Li-Zheng-Zhu's scheme owns designated verification property;moreover,the improved scheme has reduced one bilinear paring and is more efficient than the Li-Zheng-Zhu's.


The maintenance of active conformation and biological function is important for the development of solid substrate immobilized biomacromolecules for material applications. A protein monolayer was obtained on SiO2 substrates by chemically linking a site-directed mutant of sperm whale myoglobin, A126C, which has a unique and reactive cysteine residue on its surface, to a thiol specific functional group on the silane-derivatized substrates. Fourier transform infrared (FTIR) spectroscopy of this protein monolayer suggests that a native-like secondary structure is retained for the immobilized myoglobin. In addition, the immobolized myoglobin retains its ability to bind carbon monoxide. Structural changes in the surface-bound protein were examined under variation of temperature, pH, urea concentration, and ethanol content by UV−vis absorption spectroscopy. The densely packed protein, roughly 60% surface coverage of the substrate, is as resilient to high temperature, low-pH environment, and high concentration of...


Porcine circovirus possesses a closed circular,single-stranded DNA genome.It is a causative agent of post-weaning multisystemic wasting syndrome(PMWS) in pigs,which causes significant economic losses in the worldwide swine industry.This paper summarized the genomic structure,replicative and transcriptional patterns of PCV-1 and PCV-2 and its similarities and differences,including the conformation and function of replicative origin and protein involved in virus replication,transcriptional outline,patterns of splice junction about each transcriptional unit and transcriptional efficiency of main transcriptional unit,etc.These results are useful to the study on the molecular mechanism of virulent difference between PCV-1 and PCV-2 and the development of anti-PCV drugs.


Let Sn(X) be the n-fold symmetric product of a compact connected Riemann surface X of genus g and gonality d. We prove that Sn(X) admits a Kahler structure such that all the holomorphic bisectional curvatures are nonpositive if and only if n < d. Let QX(r,n) be the Quot scheme parametrizing the torsion quotients of Or X of degree n. If g � 2 and n � 2g 2, we prove that QX(r,n) does not admit a Kahler structure such that all the holomorphic bisectional curvatures are nonnegative.


Lawrence Mott's study of the War of Sicilian Vespers provides a view of the internal organization and operations of a mediaeval fleet. While the conflict of 1282-1302 between France and the crown of Aragon for control of Sicily had broad geopolitical implications, it was also notable for having been fought primarily at sea. Mott draws on previously overlooked archival materials, most notably the battle fleet accounts of Roger of Lauria discovered in the Archives of the Cathedral of Valencia, in order to produce a detailed account with insights into the mechanics of naval warfare in this early period. Mott provides detailed information about ship construction, manning, naval tactics and strategy, and especially administration, illustrating how the fleet was created, organized and maintained despite its composition: a polyglot of different groups, including a significant but previously unknown Muslim contingent. He also offers a military biography of the inexplicably obscure naval commander Roger of Lauria, among the great maritime leaders of all time. Challenging assumptions concerning the war and mediaeval warfare in general, Mott demonstrates that it was remarkable fleet organization and leadership, not "luck" as many have claimed, that defeated the French and ultimately removed them as a major player in the Mediterranean for several centuries. Finally, Mott puts the details and statistical and typological information of his account in perspective with an analysis of the nature of sea power and its changing character over time, challenging the assumption by recent scholars that Mahanian doctrine does not apply to mediaeval naval warfare.


Representative shot peening (SP) patterns as function of SP process parameters are calculated and presented. The work scrutinises the SP process parameters affecting the development of coverage and residual stresses (RS) by tackling the following phenomena: shot interactions into the shot stream, distribution of coverage on a reference plate surface, probability of non-uniform impact and relationship of adjacent impacts with RS development. The shot stream is simulated with a 2D kinematic model and the real distribution of the two most important SP parameters, i.e., shot velocity and angle are calculated. The effect of adjacent impacts on RS built-up is examined via a finite element (FE) model, resulting to a criterion about the minimum shot distance that affects the RS field. Finally, a stochastic simulation is performed via a germ-grain Boolean model, which simulates the stochastic nature of the process and results to the definition of realistic SP impact patterns.


Because of the multi- solution of well test analysis, and no special technique method of reliability evaluation of explaration bresult, pressure distribution analysis is used to evaluate the explaration result obtained form well test, the data from the explaration is dipicted into the inter-well pressure distribution map between producers and injectors, and furtherly,the map is employed to check the accuracy shch parameters as permeability and so on, the problem of well test esplaration multi- soluaiton is overcome through adajusting pressure distribution. The formation parameters can be obtained more precissily, the reliability of well test explaration can be daviced.