In the actual industrial process, some parameters have a great influence on the production results but it is difficult to measure directly. The only way to solve this kind of problem is to use soft measurement to predict the target value. The two factors that have the greatest influence on the accuracy of soft measurement are the auxiliary variable selection and modeling methods. In this paper, a soft measurement modeling method based on conditional mutual information and autoregressive neural network was proposed. First, a mechanism analysis of the production process was performed to determine a set of candidate auxiliary variables that affect the measurement. Then used the conditional mutual information to further filter the auxiliary variables from the candidate auxiliary variable set., and determined the minimum input variables set for the soft-measurement model while ensuring measurement accuracy. This paper taken the measurement process of NOx generation of a 600MW coal-fired power plant as an example, and established a soft-measurement model by using autoregressive neural network. The experimental results showed that the prediction accuracy of the model is significantly improved and had better generalization ability after the input variables are filtered by the conditional mutual information.


In this paper modal analysis is performed on a symmetric aluminum beam which is coated with functionally graded material containing porosities. A polynomial function is used to vary the density and elasticity through the thickness of the coating, while the effective elastic modulus and density are found with classical lamination theory. To achieve a truthful modeling the gradually changing mechanical properties of the coating are modeled as 25 layers of material, while each individual layer is isotropic and homogeneous. MATLAB is used to write a finite element code and Timoshenko beam elements are used to include shear deformation effects. To show the influences of crack location, crack depth, porosity and the polynomial function index on the natural beam frequencies a parametric study is conducted. Multiple boundary conditions were also considered and it was found that the natural frequency values were significantly affected by the studied parameters.


Cystin calculi are comparatively rare. Until 1882 only fifty cases of cystinuria had been reported in the literature. Kretschmer,1in his comprehensive study of the subject of cystinuria and cystin stones, found reports of only 107 cases of the stones, including two cases of his own, which occurred in twin boys, aged 9 years. The chemical examination of these two cases demonstrated that they were pure cystin, the diagnosis having been made in each case before operation. Both patients had vesical stones. Watson and Cunningham2report one case of cystin calculus in thirty-two cases of cystinuria, Morris,3two in seventy-seven, and Sir Henry Thompson three in 114 cases. That cystinuria is a constitutional problem and the etiologic factor in cystin calculi is well known. According to Abderhalden,4"the metabolism of the cystinuria patient is always normal, and urinary stones are frequently found in the disease." That


The purpose of this study is to analyze the characteristics of animation cluster in Chuncheon. It has been over 10 years since Chuncheon was designated as the cluster raising the animation industry. The Chuncheon cluster is trying to differentiate through managing several unique strategies. In order to realize the micro-regionalism, it focuses on co-production not with domestic companies but with foreign companies. Especially, for establishing the whole concrete production pipe-line, it concerns to make co-production contracts dealing with not only for the main production part but also pre- and post-production parts. Based on these production experience, it is building the production complex in the name of ICT convergence cluster. The changed role of the policy-management organization(Gangwon Information & Multimedia Corporation, GIMC) enables these differentiated strategies by itself. The establishment of the Asian Animation Round(AAR) is recognized as the characteristic of macro-regionalism. Starting from the year of 2006, the AAR tries to place Chuncheon as the hub of animation production in Asia and focuses on constructing the network of animation production countries that have developed their production capabilities through sub-contracts. This type of production and market bloc has not been made before.


Summary. Accelerograms from the IDA network have been processed to obtain 2193 multiplet locations (apparent centre frequencies) for the fundamental spheroidal modes 0S5-0S43- Great circles connecting the 72 source-receiver pairs provide a good sampling of the Earth's major tectonic regions, although the distribution of their poles is biased to high latitudes. Estimates of the degenerate eigenfrequencies, corrected for this bias, are significantly greater than Gilbert & Dziewonski's values for l≥ 10. The differences between the observed degenerate eigenfrequencies and those calculated for radial reference models display jumps between 0S10 and 0S11 and between 0S18 and 0S19 that cannot be explained by radial Earth structure or random noise processes; we attribute these jumps to Coriolis coupling between 0Sl and 0Tl+1. The RMS relative scatter in the multiplet location measurements, corrected for noise, decreases from about 1.4 × 10−3 for l≤ 10 to about 0.8 × 10−3 for l≤ 40 and is evidently caused by aspherical heterogeneities in the Earth's crust and mantle. Corrections for hydrostatic ellipticity significantly reduce the scatter for l < 17, but the reductions at higher angular orders are less than expected; in fact, ellipticity corrections actually increase the scatter for 19 ≤l≤ 27. Implied by this observation is some kind of aspherical heterogeneity whose effects on fundamental-mode multiplet locations above l∼ 20 are negatively correlated with the ellipticity perturbation. Using high-frequency approximations we have inverted the multiplet location data for the local eigenfrequency perturbations, δωlocal, associated with the six major tectonic provinces in Jordan's regionalization. The local eigenfrequencies within the ocean basins increase systematically with crustal age, in agreement with dispersion measurements at higher frequencies, and those within the continents are most positive for Precambrian cratons. The δωlocal values for the cratons are generally greater than those for average ocean basin and comparable to those found in older oceanic regions. The local eigenfrequency variations decrease in absolute magnitude with decreasing angular order number, but they remain coherent to frequencies as low as 2 mHz (0S12). We present evidence which suggests that non-asymptotic effects contribute appreciably to the data variance at low frequencies and thus may corrupt the local eigenfrequency estimates derived from the asymptotic theory.


The difficulties of learning to read are a reality increasingly common among infants of the education systems of today. These difficulties, conceptualized by the American Psychiatric Association under the name of dyslexia, have a prevalence of between 3% of girls and 5% of the children, following the same sources. The investigation was subsequently introduced and which served as a doctoral thesis developed by the Department Evolutionary Psychology and Education at the University Complutense of Madrid, shows the study realized on a sample of 80 subjects between 7 and 11 years of age, students of public and private institutions of the Community of Madrid, divided into a control group of 50 subjects normal readers and an experimental group of 30 subjects diagnosed as dyslexic, who were administered Neuropsychological Battery for Kids (Manga and Ramos,1991). We will see, then, in an attempt to explain the behavioral projections of minimal brain dysfunction hypothesized by Luria and corroborated by multiple studies (Galaburda et al, 1973), if there are


This large scale study (869 participants from a mental health Trust) employed a questionnaire based on an interactional model of occupational stress to investigate (i) burnout in psychiatric nurses, (ii) occupational stress in medics and the professions allied to medicine, (iii) job satisfaction in health service management and support staff, and (iv) the moderating effect of social support in health service personnel. A range of analytic procedures were used including hierarchical regression analysis. Levels of burnout in nurses were low overall, although a significant proportion reported higher levels of emotional exhaustion. Among nurses, negative affectivity and predictability acted as common factors across the three constructs of the burnout syndrome. Medics and professions allied to medicine (P.AM. 's) reported similar levels of stressors to each other. Role ambiguity, role conflict and predictability, in combination with negative affectivity, accounted for most of the reported work related stressors of medics and P.AM. 's. Levels of job satisfaction in management and support staff was on a par with their peers elsewhere. Role ambiguity, role conflict,job future ambiguity, control and non-occupational concerns had an influence on job satisfaction among management and support staff. A significant proportion of nurses, medics and P.AM.'s reported low levels of work support. Those most at risk in this regard appeared to be highly educated, community based, non-shift workers. Higher levels of support were associated with increased job satisfaction and lower levels of both emotional exhaustion and psychological distress. The model adopted in the present study, although not necessarily applicable to all occupational groups, had utility in understanding the complex relationships between variables in this population from a mental health Trust. Despite common themes emerging across occupational groups, clear differences were also apparent, reinforcing the need for tailor-made interventions in occupational stress. The results also highlighted the necessity of including individual characteristics and nonoccupational stressors in any consideration of occupational stress. Further recommendations for each occupational group and the NHS in general are discussed.


Significance αI integrins have 13 extracellular domains in two subunits; communication between these domains is key to regulating affinity. Structures of integrins that contain a special ligand-binding domain, the αI domain, reveal it is linked in a highly flexible manner to the β-propeller domain. Differences among αI integrin β-propeller domains concentrate at the interface with the αI domain and the binding pocket for an internal ligand that relays allostery between αI and βI domains. We reveal in many integrins a mechanism by which allostery can be communicated by concerted motions of two loops that form the interface in the βI domain for both internal and external ligands. The motions markedly increase complementarity for ligands. High-resolution crystal structures of the headpiece of lymphocyte function-associated antigen-1 (integrin αLβ2) reveal how the αI domain interacts with its platform formed by the α-subunit β-propeller and β-subunit βI domains. The αLβ2 structures compared with αXβ2 structures show that the αI domain, tethered through its N-linker and a disulfide to a stable β-ribbon pillar near the center of the platform, can undergo remarkable pivoting and tilting motions that appear buffered by N-glycan decorations that differ between αL and αX subunits. Rerefined β2 integrin structures reveal details including pyroglutamic acid at the β2 N terminus and bending within the EGF1 domain. Allostery is relayed to the αI domain by an internal ligand that binds to a pocket at the interface between the β-propeller and βI domains. Marked differences between the αL and αX subunit β-propeller domains concentrate near the binding pocket and αI domain interfaces. Remarkably, movement in allostery in the βI domain of specificity determining loop 1 (SDL1) causes concerted movement of SDL2 and thereby tightens the binding pocket for the internal ligand.


Recently Solid-State Battery has received increased attention as the next generation energy storage device due to its high energy density, improved safety, and thermal stability. Among various types of solid electrolytes (SE), lithium (Li)-stuffed garnet-type Li6.75La3Zr1.75Ta0.25O12 (LLZT) delivered high ionic conductivity (~10-4 S/cm) and wide electrochemical stability window. Despite such promising properties, there are few technical challenges that prevent the implementation of LLZT in practical battery cells. First, LLZT suffers from a high interfacial resistance due to its poor wettability in contact with Li metal anode. Second, LLZT suffers from Li-dendrite penetration through grain boundaries during cycling. The grain boundaries have high electrical and low ionic conductivities which attracts Li-ions and electrons and nucleates metallic Li. Additionally, poor wetting between Li-anode and LLZT causes their limited contact at the Li/SE interface. Electrical current will be concentrated on those limited interfacial areas and accelerate the Li nucleation and subsequent dendritic growth.
 To address these issues, various strategies have been proposed including elemental doping, in-situ solid-electrolyte interface (SEI) formation, and interlayer engineering. Among these strategies, amorphous glass layer between Li-anode and LLZT has advantages of simple processing and manufacturing friendliness, which involves heating to melt a glass followed by a fast cooling. Therefore, moderate melting temperature (e.g., T < 800 oC) is an important selection criteria for suitable glass material candidate. In addition, the coating layer should have reasonably good ionic conductivity .
 In this study, we selected and investigated Li3BO3 (LBO) as the glass interlayer based on its low melting temperature (~700 oC), good stability between Li metal and LLZT, and moderate ionic conductivity (~ 10-6
 S/cm). A systematic design of experiments was performed to understanding the synthesis parameter – microstructure – performance relationship. First, we examined the effect of temperature programs (e.g., heating/cooling rate, temperature, time) and slurry composition on the microstructure of the LBO glass layer coated onto LLZT pellet. Scanning electron microscopy (SEM) revealed that homogeneous LBO layer without cracks or pinhole could be obtained by optimizing the parameters.
 Secondly, we investigated the effect of LBO glass interlayer on the electrochemical properties of the solid-state battery cells. Introducing LBO interlayer to a Li/SE/Li symmetrical cell (i) increased cell interfacial conductivity from 1.32*10-4 to 1.06*10-3 S/cm as evidenced by electrochemical impedance spectroscopy (EIS) and (ii) increased critical current densities (CCD) from 0.1 mA/cm2 (baseline) to 0.4 mAh/cm2. Finally, we performed extended plating/stripping cycling test from the symmetric cells at a specific current of 0.1 mA/cm2. Although the bare LLZT cell failed after 10 cycles, the cell with LBO interlayer operated without short-circuit for 93 cycles. The electrochemical characterization test clearly demonstrated that the LBO layer stabilize the Li/SE interface by improving a tolerance against the Li-dendrite penetration. Our promising results will offer a useful guideline for the future researchers on the design and optimization of the solid-state battery interfaces.


The DIAMOND study demonstrated real-time continuous glucose monitors (CGM) improve glycemic control for adults with T1D using multiple daily injections; subsequent analysis showed greatest benefit in participants with higher baseline A1C. This analysis assesses the relationship between baseline time in range (TIR) and change in TIR during the study with CGM or self-monitoring of blood glucose (SMBG). Baseline TIR was divided into three categories: 4 h/d increase in TIR across all baseline TIR groups, and >2 h/d increase in TIR in most baseline TIR groups, although a few were not significant due to small sample size (Figure). The most noticeable difference occurred for participants with a baseline TIR 4 h/d compared with no SMBG users (P=0.004). Similar trends were found for improvement in mean glucose and time spent in hyper- and hypoglycemic ranges. Overall, results suggest greater improvement in glycemic control for CGM users than for SMBG users across all baseline TIR groups. Disclosure P. Calhoun: Stock/Shareholder; Self; Dexcom, Inc. D.A. Price: Employee; Self; Dexcom, Inc. R. Beck: None. Funding Dexcom, Inc.


Three cross-linking polystyrene resins functionalized with formylgroups,pformylphenoxymethyl,p-formyl-2-methoxyphenoxymethyl and p-formyl-3-methoxyphenoxymethyl were reduced by NaBH_4 under phase transfer catalytic conditions coupling with microwave irradiation(MI-PTC),and three benzylhydroxyl resins,the Wang resin,Sasrin resin and a novel p-benzylhydroxyl-3-methoxyphenoxymethyl resin were correspondingly obtained.The preparations of these resins were carried out under heating in water batch and microwave irradiation.The reaction monitoring was performed by FTIR,and the contents of hydroxyl groups of target resins were determined by nitrogen element analysis involving derivative reaction of 3,5-dinitrobenzoyl chloride.The influence factors such as solvent and phase-transfer catalyst were experimentally investigated.The optimized solvent was THF/H_2O among DMF,ethanol,THF,and THF/H_2O,and the optimized phase-transfer catalyst was benzyltrihydroxylethyl ammonium chloride(BTHAC) among BTHAC,PEG-400,cetyl trimethyl ammonium chloride(CTMAC),tetrabutylammonium chloride(TBAC).However,the mixture ratio of the optimized solvent was different for reations with traditional heating and microwave irradiation.Under heating in water batch,the optimized solvent was 12 mL THF+3 mL H_2O,while that was 3 mL THF + 12 mL H_2O under microwave heating.The polymer-supported formyl groups were almost quantificationally converted into hydroxyl groups in 30 minutes under the optimized conditions and 60 W power microwave input,while under the traditional heating the reaction time exceeded 24 h and the conversion extent of formyl groups was somewhat less.Compared with that of conventional heating,the reduction of formyl supported by crosslinking polystyrene under MI-PTC by NaBH_4 was a good method with short reaction time and improved conversion.


This essay focuses on a poem, a political event, and a series of paintings of the mid-seventies: John Ashbery's "Self-Portrait in a Convex Mirror" (1974),' which Henry M. Sayre, in The Columbia Literary History of the United States, calls "perhaps the most famous poem of the 1970s";2 the Watergate affair-unquestionably the most famous American political episode of the 1970s; and Jasper Johns's crosshatch paintings (see Scent [1973-1974], Figure 1), which use the first abstract motif to dominate paintings by Johns,3 the living American artist who, for the longest period of time, has consistently produced unexpected and critically renowned art.


The goals pursued by the US Department of Homeland Security (DHS) require the collaboration of dozens of federal agencies and thousands of state and local entities. Intergovernmental funding within DHS has become one of the most politicized and criticized aspects of this process. This study analyzed the US Department of Homeland Security's state grant program from 2002 to 2007 to examine whether strong incentives to distribute these funds politically overrode the impetus to distribute them according to greatest risk or need. Using a random effects panel data model, several independent variables reflecting political and risk factors were regressed to examine the extent each of these factors affects the funding process. This paper further advances the research by explicitly comparing the relative importance of political versus risk factors over a 6 year time period with particular focus on whether allocations within Homeland Security's state grant program are primarily determined by political or objective criterion. The research found, that the political variables are more consistently significant predictors of allocations than the risk variables. The findings also provide evidence that formula grants, administered to states, by federal agencies are still susceptible to political influence.


Extreme stock price behavior has become more recognized in the investment literature. Recent work by Glascock and Lu-Andrews shows that larger firms with high measures of liquidity react in a stronger manner to market related extreme events. These stocks also experience stronger stock price reversals on day 1 after the event. In this research, we examine the behavior of REITs around large market price events. Our results show that REITs that are larger and that have high liquidity behave as other stocks and react strongly to these events and have strong reversals of price on day 1 after the event. Overall, we argue that size and liquidity establish these REITs as being more market-related that other REITs.


Abstract Frequency properties of electromagnetic waves scattered by 1D random photonic lossless structures, periodic on average, are studied by means of the transfer-matrix method. It is shown that a high degree of disorder in the distribution of dielectric scatterers produces a very narrow window for the frequency of the transmitted light. Several general frequency-dependent characteristics of the scattering process have been investigated for an arbitrary degree of disorder.


PURPOSE
To compare digital subtraction angiography with three-dimensional phase-contrast magnetic resonance (MR) angiography in detection of significant renal artery stenosis.

MATERIALS AND METHODS
Sixteen patients underwent digital subtraction angiography and systolically gated three-dimensional phase-contrast MR angiography within 1 week. Scoring of stenosis on MR angiograms was based on presence and length of a flow void and quality of flow signal intensity in the distal part of the artery. Intraarterial pressure measurement was the reference standard for hemodynamically significant renal artery stenosis.

RESULTS
MR angiography depicted two of five patent accessory arteries. Comparison of digital subtraction angiography and MR angiography with intraarterial pressure measurements was possible in 25 main renal arteries. In 13 arteries, a pressure gradient of more than 15 mm Hg was found. Digital subtraction angiography depicted 10 of these stenoses (sensitivity, 77%; specificity, 92%). A flow void was present at MR angiography in eight stenoses (sensitivity, 62%; specificity, 83%). In 12 of the stenosed vessels, distal flow signal intensity was impaired at MR angiography (sensitivity, 92%; specificity, 75%). There was no difference between the two modalities (P > .05) in grading hemodynamic significance of renal artery stenosis.

CONCLUSION
Systolically gated MR angiography and digital subtraction angiography are equally effective in depicting hemodynamically significant stenoses in the main renal arteries. MR angiography, however, is not adequate in depiction of accessory renal arteries.


Since the 1990s, the Chinese classic poetics has seen great achievements in the ten branches of studies, including history of poetics, documents of poetics, case study of poetics, poetic schools and communities, cultural poetics, regional poetics, reception poetics, scope of poetics, academic history of poetics and Chinese poetics abroad. This marks the strength of the study of classic Chinese poetics and foretells the basic trend of it during the scores of years.


iii CHAPTER 1: LITERATURE REVIEW AND THESIS ORGANIZATION 1 CHAPTER 2: EVALUATION OF AN ORGANIC NO-TILL SYSTEM IN TWO CROP SEQUENCES IN IOWA 19 CHAPTER 3: EVALUATION OF AN ORGANIC NO-TILL SYSTEM WITH VARIOUS COVER CROPS FOR ORGANIC CORN PRODUCTION 39 ACKNOWLEDGEMENTS 62


As an important ecological hinterland in Hunan Province, the Dongting Lake area has an irreplaceable role in regional socioeconomic development. However, owing to rapid environmental changes and complex land use relationships, land use/land cover (LULC) changes are actively occurring in the region. Therefore, assessment of the current LULC status and the future development trend for sustainable economic development is of considerable importance. In this study, the driving mechanisms of spatiotemporal evolution for land use conflicts (LUCF) in Dongting Lake from 2000 to 2020 were analyzed by constructing a LUCF model. Additionally, a new model, EnKF-PLUS, which couples ensemble Kalman filtering (EnKF) with patch-generating land use simulation (PLUS), was developed to predict the LULC changes and LUCF in 2030 under different scenarios. The results provide three insights. First, during the period of 2000–2020, high LUCF values were concentrated in highly urbanized and densely populated areas, whereas low LUCF values were centered in hilly regions. Secondly, the impacts of static factors (topographical factors) and dynamic factors (population, GDP, and climate factors) on changes in LUCF were regionally differentiated. Thirdly, our results indicate that the implementation of land use strategies of cropland conservation and ecological conservation can effectively mitigate the degree of LUCF changes in the region and contribute to the promotion of the rational allocation of land resources.


to practical. The student work is seen by much of the campus population as well as the external community. Having their artwork permanently displayed also gives the artist a lifelong connection to the building, institution, and local community. The celebration of student artwork during the reception brings attention to the collection and offers an equivalent celebration for these fine artists to the end-of-the-year research event associated with experiential learning in other disciplines, such as a research symposium or design expo. The student art in the CCLIR also shows, in a physical way, that the library is interested in students and their creative work, even to students outside the Department of Art. Valparaiso University's role as a teaching institution is reflected in the library's relationship to and reputation among students. As Kam (2001) states, 'By collecting art objects, we exercise our role as key cultural players in society while also reinforcing out institutional identities' (p. 14). An art piece in the library is viewed differently, in its intended purpose, than it would be viewed in the student union or in the university Chapel. Art pieces are viewed not only by the award winners and art students, or indeed any student, but are also seen by faculty,


There are a device and a method for controlling lamps disclosed, which are present in a donor and a backlight control buttons of a arrays. According to the invention at least one lamp present in the dispenser and it is also an illumination sensor for detecting the ambient brightness provided by a refrigerator or a sensor for detecting that a user approaches the refrigerator. There also exists a storage unit for previously storing a reference luminosity, whose value can be changed by the user. It is also a lamp driving unit for selectively controlling the brightness of the lamp by controlling its output signal according to a driver control signal to a control unit exists. According to the invention, the user can see easily ice or water from the dispenser, because the lamp is turned on. It is also possible, since the reference light intensity can be changed and stored in relation to ambient brightness around the refrigerator to control the condition for switching on or off of the lamp according to the environment or the user's taste. Moreover, since the donor and the backlight is normally lit with the minimum brightness, easy to use the dispenser and as the dispenser and the Hintergrundgeleuchtung lit for a predetermined time period with the maximum brightness and the illumination is gradually ...


The differential effectiveness of Bibliocounselling [BC] and Rational Emotive Behaviour Therapy [REBT] in fostering emotional adjustment among inschool adolescents in Edo State, Nigeria was the focus of this paper. Three hypotheses were formulated and tested in the study. The study adopted the quasiexperimental research design. The purposive random sampling technique was used to draw a sample of 45 participants consisting of 15 participants for the first treatment [BC], 15 for the second treatment [REBT] and 15 for the control group –Personal Hygiene/Teaching from a population of 1,783 of in-school adolescents. The Kulyam's kulvan's (2017) Emotional Adjustment Scale was adapted for the study. A total of five sessions (45minutes per session) was covered in both the treatment and control groups. The mean and standard deviation were used to answer the research question, while the Analysis of Covariance and the t-test for two independent sample means were used to test hypotheses at 0.05 level of significance. Although both treatment methods were effective in fostering emotional adjustment among in-school adolescents, the participants exposed to REBT showed more improvement over those exposed to BC. It was therefore recommended among others that counselors should use more of REBT to help foster students' emotions.


In this paper, we propose a high-definition (HD) video real-time edge detection system, also presenting its hardware design and implementation results. Traditional median filtering blurs image details while removing noise, therefore we propose the improved median filtering algorithm which not only effectively removes impulse noise, but also retains more image details. For the problem that traditional sobel edge detection algorithm easily loses graphic details. This paper proposes the improved sobel edge detection algorithm which extends the gradient direction to eight, introducing local adaptive threshold and non-maximum suppression. The proposed algorithms were designed with Verilog-HDL, and the real-time operation was verified and evaluated using an field programmable gate array (FPGA) based test system at an operating frequency of 200MHz for 1280×720 HD video.


In conclusion, metastatic RCC has been a prototype of targeted cancer therapies as a result of advances in molecular medicine. Axitinib and RT combination approaches, one of the targeted therapies, have been shown to increase radiosensitivity in preclinical studies. The evaluation of the treatment regimens and the results of the Axitinib and RT combination therapy for metastatic RCC cases with phase 2 and 3 studies will be important for the patient.


The Data Envelope Analysis (DEA) is a technique that has been implemented in order to assess the effectiveness of various entities, including programs, organizations, and so on. They are accountable for making use of the available resources in order to obtain outputs that are of interest. It has been applied to the task of analyzing a variety of activities. The DEA is a fractional programming model that can contain multiple outputs and inputs without having to resort to prior weights or explicitly stating the functional relationship between inputs and outputs. This is because DEA is a model that is based on dynamic programming. It computes a scalar measure of efficiency and establishes the level of efficiency at both the organization's inputs and outputs that are being evaluated. The assessment of the excellence of English instruction in universities and colleges is primarily plagued by two issues: first, the evaluation index system is lacking in its coverage, and second, the evaluation model struggles when confronted with highly nuanced signs. In order to find solutions to these issues, in this work, we delve deeply into the topic of assessing the quality of English instruction in colleges and universities and develop a model for doing so that is based on the DEA fusion algorithm. To assess the quality of English instruction provided by colleges and universities, a model, that takes into account both quantitative and qualitative research findings, has been developed. The findings of the implementation suggest that the DEA fusion algorithm that was proposed is capable of successfully assessing the quality of English instructions and teaching provided in colleges and universities. The proposed algorithm outperformed the traditional Multilayer Perceptron (MLP) algorithm and the Decision Tree (DT) algorithm. The findings of this research have been very helpful in encouraging the enhancement of the quality of English instruction in colleges.


X-Ray crystal structure determination and spectroscopic measurements on the title compound show it to have an asymmetrically bridging CO ligand which is believed to lead to some valence disproportion in contrast to its precursor [Pt2Br4(CO)2]2–.


Mandatory restrictions in employment law, designed to promote the welfare of workers, are debated fiercely. Proponents argue that they protect workers. Opponents believe that they spawn inefficiency and harm workers. Yet all agree that their welfare implications depend on their degree of enforcement.This Article challenges the conviction that the welfare implications of such restrictions depend on enforcement. We show experimentally that unenforced restrictions cause workers' reservation wages to rise, i.e., workers charge higher wages when offered contracts that violate such restrictions. This observation is important to both proponents and opponents of such restrictions. We establish this claim experimentally by measuring the effects of unenforced restrictions on workers' reservation wages. Then we investigate several hypotheses as to why these effects are generated. Last, we point out that our findings have important implications in other contexts of contractual regulation, such as in the domain of consumer protection.


The recent literature on unified growth theory has shed new light on the transition to sustained economic growth. Nevertheless, unified growth theory has not devoted a lot of attention to the nature of economic growth and its impact in the transition from Malthus to Solow. This research presents new evidence on the existence of pre-industrial growth spurts and provides new foundations concerning the nature of economic growth during the Malthus to Solow transition. Following previous research in unified growth theory, sustained economic growth arises due to complementarities between the triple engines of growth of technological development, human capital and the organization of the workplace. In this research, growth spurts are an intrinsic feature of the economy, but throughout history their effect on standards of living is mostly temporary. The rise in living standards only becomes sustained when the complementarity of the triple engines of growth emerges. In Malthusian economies, most technologies were basic and only require straightforward knowledge or human capital, and thus the skill-technology complementarity did not play a role in their development. As a consequence, most technological developments in Malthusian economies generated growth spurts that did not become sustained, although there was a temporary increase in standards of living. However, the increasing complexity of the epistemic knowledge base reported by the historical literature meant that investments in applied technology were progressively more significant, enhancing the role of human capital. After a certain threshold of the knowledge base was surpassed, more and more complex applied technologies were developed, and growth spurts became permanent features of the economy. This research thus captures some of the most important historical features concerning the nature of growth in the transition to sustained economic growth.


The Committee on Hospital-based Laboratory and Clinical Immunology had been charged by the Council of the American Association of Immunologists with the task of defining clinical immunology, determining the scope of clinical and laboratory immunology activities within a hospital setting, and exploring the scientific and practical advantages inherent in the creation of Clinical Immunology Units. The deliberations of the Committee were influenced by the growth of immunology during the past 20 years from a discipline concerned with immunity to infectious diseases, into a science concerned with the characteristics and effects of the immune response per se. The science of immunology has been rapidly applied to problems in human biology and pathology, and as a consequence, applied immunology has had a significant impact on all aspects of medical practice.


Today sunscreens are expected to protect not only against sun burn, but also against long term damaging effects. This means that UV-A filters become more and more important. Until recently the offering of such filters was very limited. With the year 2000 the situation started improving steadily. With MBBT (Methylene Bis-Benzotriazolyl Tetramethylbutylphenol), BEMT (Bis-Ethylhexyloxyphenol Methoxy-phenyltriazine) and DPBT (Disodium Phenyl Dibenzimidazole Tetrasulfonate) three new, photostable UV-A and broadband filters have been added to the positive list of the European cosmetic UV filters. Since the methods to assess UV-A protection are not harmonized in Europe, the Australian standard AS/NZS 2604 is frequently claimed in Germany. The application of the two relative in vitro methods »critical wavelength« and »UV-A/UV-B ratio « shows that the highest protection class is significantly easier to achieve with the former one. The PPD method (Persistent Pigment Darkening) has become the in vivo standard in Japan. Its advantage is the absolute value and the fact that photostability is taken into account implicitly. This allows a comparison of the conventional, unstable UV-A Filter BMDBM (Butyl Methoxydibenzoylmethane) with the modern photostable UV-A Filter MBBT. The new photostable UV-A/ Broadband filters are discussed and the first commercial applications of their use are also taken into consideration.


Alluvial sediments are important for exploration of gold, diamond, ilmenite, etc. It is important to search for such kind of deposits by using ground sampling. The important question is that, where to collect samples? One has to have a comprehensive knowledge of the regional geology, the type of expected source rocks, the geomorphic and climatic factor and the type of deposits considered for exploration. By refereeing to the geological maps, one can not classify the alluvial deposits based on their source rocks. They are usually classified according to their type (silt, clay, gravel, sand etc.) or according to their age (quaternary, Recent etc.). As the alluvial deposits are composed of different assemblages of minerals, it is possible to map the alluvial deposits based on their source lithologies by using multispectral satellite images. In the arid and semi-arid types of climate it is much easier to separate different alluvial deposits according to their source lithologies. In this study Both ASTER and ETM+ data are used to show that the source lithologies and the spatial distribution of their alluvial deposits can be clearly mapped by different image processing techniques. Once this is done, the sampling design should be very cost effective. Shahre-e-Babak and Kahnouj areas which are located in Kerman province in Iran are chosen as test areas to show the capability of remote sensing technique for the exploration of alluvial deposits.


Six isozymes, LDH, ADH, MDH, EST, AMY, and POD, in different stage embryos and aborted embryos in Eriocheir sinensis were investigated with polyacrylamide gel electrophoresis. The results showed that the activities of LDH, ADH, MDH, EST and AMY were different in embryos at different developmental stages. LDH isozyme could not be detected in fertilized eggs, while four isozyme bands emerged in cleavage and blastulation stage embryos and two isozyme bands in nauplius and zoaea stages; ADH isozyme was expressed in all stages of embryonic development, but there were differences in enzyme bands and enzyme activities. No MDH enzyme bands were observed in fertilized eggs and at zoaea stages, while most bands and the strongest activities emerged at cleavage stages. With the development, the MDH enzyme bands and activities became weakened. The changes in EST isozyme were more complicated, with sudden disappearance at blastulation stage. The band number of AMY, both (α-AMY and R-AMY) decreased from fertilized eggs to larver stage.The POD activity could not be detected in all developmental stages. The enzyme activities and bands of the second spawning embryos were different from those of the first cleavage stageembryos. The ADH, LDH, and AMY isozyme bands of aborted embryos had slight differences compared to the first spawning embryos at different developmental stages, while MDH, EST isozyme bands decreased dramatically in aborted embryos.


Rivers and the construction of identity The collection of youth memories "Met 'n eie siekspens" (Engela van Rooyen) and the novel "Manaka: plek van die horings" (Pieter Pieterse) complement each other as literary embodiments of the phenomenon that human life and identity are influenced by an aspect of the characters' natural environment, namely the river. This article focuses on the nature and extent of the influence of rivers on the development of identity in characters in these two works. In "Met 'n eie siekspens" the formative role of the Orange River is connected with a complex relationship between man and river in which elements of devotion collide with those of enslavement. The values taught by the river and its surroundings are core components of the characters' identities. In "Manaka: plek van die horings", the main character's dream of a life on the Zambezi is part of his identity, in that it embodies selfrealisation and has directed his thinking and self-image since childhood. The river and its surroundings, however, later on also play an important role in the re-interpretation of his life goal and the acquisition of a wider understanding of his true identity. This investigation underlines the importance of research into the portrayal of the relationship between man and nature within the broader field of study in which the portrayal of matters of identity in Afrikaans literature is investigated.


We evaluated an immunoenzymatic assay (Abbott HTSH EIA) for thyrotropin (TSH) as a tool for detecting hyperthyroidismand for monitoringthyroidhormone suppressive therapy in patients with nodular goiter, thyroid carcinoma, and hypopituitarism. We also tested with thyrolibenn (TRH), to determine the correlation between peak and basal TSH in suppressed patients. For comparison, we used a nonequilibrium radioimmunoassay optimized formaximum sensitivity (J Clin Endocrinol Metab 1975;41 :676). Hyperthyroid patients with values for either or both triiodothyronine and thyroxin above the normal reference interval had Abbott assay values 0.2 milli-int. unitlL, clearly below the Abbott assay normal range, as determined in 116 euthyroid subjects. We detected one-thirdof the suppressed patients( 0.3 mull-mt.unit/L) with RIA, 69% with the Abbott assay (TSH 0.04 milli-int. unitlL). Only 20% of patients with undetectable basal TSH values in the Abbott assay responded to TRH with a detectable peak TSH value; the peak TSH value after TRH was proportional to the basal TSH value. A single basal TSH measurement by the Abbott HTSH EIA should be adequate for monitoring the degree of thyroidal suppression in thyroidhormone-treated patients.


the intraportal zone into the immediate periportal zone. Kupffer cells and hepatic stellate cells became enlarged at the borders of the necrotic and non-necrotic central zone and then appeared to migrate into the oval cell population expanding across the periportal zone. During the restitution phase, hepatic stellate cells were closely associated with the proliferating oval cells, surrounding small aggregates of oval cells which appeared to be forming liver cords. Kupffer cells also stained for fibronectin, and fibronectin was seen at the intersection of the injured portal and uninjured central zones and around the expanding oval cells. In some intraportal zones, the lamhrin surrounding the bile ducts was lost. It was speculated that this may permit proliferating ductular cells to migrate out of the bile ducts into the periportal zone. By days 6 and 7 most of the injured liver was restored to normal, with a few foci of chronic inflammation remaining. Conclusions: There is a close anatomic relationship between immature liver lineage cells (oval/duct cells) and non-parenchymal cells during the restitutive repair of periportal injury. The nature of this relationship to the possible production of growth factors and expression of growth factor receptors by the cells involved during the restitution process is discussed.


To determine the prevalence, types and awareness of glaucoma in a rural community in China and to examine possible ethnic variations.


We review several procedures of quantization formulated in the framework of (classical) phase space M . These quantization methods consider Quantum Mechanics as a "deformation" of Classical Mechanics by means of the "transformation" of the commutative algebra C∞(M) in a new non-commutative algebra C∞(M)h̄. These ideas lead in a natural way to Quantum Groups as deformation (or quantization, in a broad sense) of Poisson–Lie groups, which is also analysed here.


Chinese design education,especially higher design education,how to use for reference the western modern design education,digging the quintessence of Chinese traditional culture with Chinese characteristics formed on the basis of the design education system,it has been exploring the line.As a leader of design education,professional design teacher should not only meet the needs of the market professional master the skills,but also have a broad field of vision,a multicultural mind,have the systematic and perfect professional discipline knowledge,and have extensive and profound culture theory accomplishment.Professional design teacher,both designer and thinker,should get comprehensive design education knowledge structure.


A design-oriented simulation technique for predicting the crash behaviour of automotive side structure without requiring complete vehicle geometry is presented. The technique is based on reduced-order finite element analysis using beam elements and non-linear discrete elements. The localised bending collapse of the pillar is represented by nonlinear springs, and the joint flexibility is accounted for using revolute joint elements. The pillar intrusion levels predicted by the reduced-order model compare well with the corresponding shell element model in both elastic and fully plastic loading cases.


: The interest in robots is also increasing with the rapid increase in technology. In many manufacturing applications, robots must work alone or they must work with human. Many businesses do not have knowledge and experience in the robotics, so they are lagging behind the technology. Human-robot interaction (HRI) will enable that non-expert human easily controls robots and, therefore, the use of the robot will become widespread. These robots, which are widespread, must not only execute the desired task but also provide human safety existed in the working environment. Hence, safe human-robot interaction software (SHRIS) was developed in this study and the safety of the human working in the same environment as the robot was undertaken control. SHRIS collects visual and audio information from the working environment using multimodal communication. According to this information, SHRIS determines the danger level of the environment by using convolutional neural network and controls the speed of the robot. Developed SHRIS was tested on KUKA KR Agilus KR6 R900 sixx, which is industrial robots, and successful results were obtained.


Cancer is a life-threatening disease and leads to high rates of mortality worldwide, after cardiovascular disease, is the second leading cause of death. Investigations for finding new plant based anticancer compounds are imperative and interesting. There are many studies on anticancer herb/plant extracts in cell line models. Eugenia jambolana has been reported to contain phytochemicals like coumarin, flavanoids, glycosides, phenols, tannins and steroids. The various part of Eugenia jambolana have therapeutic applications. Plant active components were extracted using the decoction extraction method and the filtrate was obtained by means of filtering through a Whattman no.1 filter paper. The filtrate was evaporated in a weighed flask in a hot air oven set at 50°C. Extracts were reconstituted by re-dissolving in respective solvents. Different concentration i.e. 8, 15.6, 31.25, 62.5, 125, 250, 500 and 1000 µg. of the plant extracts were tested for the anticancer activity. The anticancer assay was performed on Human laryngeal epithiloma cells (Hep 2) obtained from King Institute of Preventive Medicine, Chennai, India. The cell viability was measured using MTT assay. Controls were maintained throughout the experiment (Untreated wells as cell control and diluent treated wells as diluent control). The assay was performed in triplicates for each of the extracts.


By optimizing the kind,shape and content of pigments with EPDM as adhesive,low infrared emissivity coatings EPDM/Cu and EPDM/SS of 0.14 at spectral range of 8~14 μm were prepared.Based on the infrared emissivity,reflection,electrical conductivity of the coatings were measured while the structure and the surface morphology of the coatings were characterized by infrared absorption spectrum(IR) and scanning electron microscope(SEM).The principle of the low emissivity coatings was discussed in the aspect of reflection,conductivity,chemical structure,surface morphology and so on.The mechanical performances of coatings were evaluated in terms of heat resistance,adhesion and hardness test.It was shown that the coatings had achieved good performances in engineer applications.


A new technique for the measurement of the electron saturation velocity in GaAs FET's is proposed using the "end" resistance measurement. The measurements performed on 1.3-µm gate-length ion-implanted GaAs MESFET's lead to the values of the saturation velocity ranging from 1 to 1.3 × 105m/s.


ABSTRACT The poll tax was introduced by the Thatcher Government to Scotland in 1989, one year ahead of the rest of Britain. Rooted in neo-liberal ideas of rational individualism, an economic theory of electoral behaviour was implicit in the political justification for the tax. The Scottish Regional elections in 1990 provided a unique opportunity to test the public's reaction to a significant redistribution of local tax costs. Drawing upon aggregate data from urban Scotland and a postal survey of electors in four District authorities, this paper argues that the poll tax failed to support the central expectations of the economic voting thesis — that the redistribution of local taxation would prompt a marked increase in electoral turnout as electors focused more clearly on the costs and benefits of different policies, or that voters facing the largest tax increases would turn out to vote in larger numbers. The most striking pattern in 1990, compared to the previous election in 1986, was one of turnout stabil...


Abstract A distribution-free test is considered for testing main effects in a two-factor ANOVA. Large-sample properties (cell sizes tending to infinity) including efficiencies and the limiting distribution of the test statistic are obtained. For proportional frequencies a simple sum of squares formula is obtained for the test statistic and multiple comparison procedures are given. For general designs the statistic is expressed using generalized inverses. Some tables for the null distribution of the statistic are also given.


Science learning has been considered a difficult subject for students. This study aims to analyze student error answers on students' science understanding abilities on energy concepts to find out students' difficulties in answering energy concept science questions through Conceptual Change Text (CCT) based learning. This CCT-based learning requires students to be more active in understanding concepts with the help of reading materials that have been provided by the teacher so that students can find concepts independently. The reading material given to students is in the form of reading material about energy. This research was conducted on third, fourth, and fifth-grade elementary school students to determine the level of difficulty at each level. This research method is a qualitative method using grounded theory. The instrument used is a test instrument. Student answer sheets to analyze the types of errors made by students in accordance with the energy concept learning indicators. Based on the results of the study obtained, data on the average error rate of third, fourth, and fifth-grade students on the concept of energy. The data shows that the third grade has an average error of 30.34%, the fourth-grade student's average error is 21.64%, and the fifth-grade student's average error is 14.39%.


This document provides the basis for the mechanical design adequacy of the 225-B Waste Encapsulation and Storage Facility (WESF) Emergency Ion Exchange (EMIX) piping system.


Abstract. In this paper we investigate the influence of contextual knowledge for the classification of airborne laser scanning data in Wadden Sea areas. For this propose we use Conditional Random Fields (CRF) for the classification of the point cloud into the classes water, mudflat, and mussel bed based on geometric and intensity features. We learn typical structures in a training step and combine local descriptors with context information in a CRF framework. It is shown that the point-based classification result, especially the completeness rate for water and mussel bed as well as the correction rate of water, can be significantly improved if contextual knowledge is integrated. We evaluate our approach on a test side of the German part of the Wadden Sea and compare the results with a Maximum Likelihood Classification.


Solid particle erosion of polymer composites is a complex surface damage process, strongly affected by material properties and operational conditions. The present research work is undertaken to study the development, characterization and erosion wear performance of two different categories of fibers when reinforced in polymers. One of the two fiber is well known synthetic fiber i.e. glass fiber which is commercially used by many industries and the other fiber will be a natural fiber i.e. banana fiber which will be the new attempt in the present investigation. In both the above cases matrix material will remain epoxy. Attempts have been made to explore the possible use of a natural fiber as filler material in composites. To make an assessment of their (banana fiber) reinforcing potential in terms of wear performance and mechanical properties, various physical, mechanical and wear performance of the composites are studied in details and its comparison with a similar set of composites with glass fiber as a filler material is reported. The reported data are purely extracted from experimental measurement under controlled laboratory conditions. From the performed experiments it can be seen that a banana fiber can successfully replace the glass fiber as far as wear performance in concerned, as the study indicates that erosion wear performance of banana fiber based composites is better than that of the glass fiber reinforced composites. Banana fiber is also having a very low specific gravity, so their composites show very low density as compared to glass fiber reinforced composites. From other mechanical characterization it can be said that, in strength point of view, banana fiber-epoxy composites are not very much behind its counterparts glass fiber-epoxy composites.


Abstract: The objective of this study was to describe the working conditions of professionals who work in centers providing assistance to women victims of violence, to investigate the experience of female workers in caring for women victims of violence and to analyze the self-care practices of this professional group at the personal, professional, collective and institutional levels. Data were collected through the application of an interview script to 12 professionals who assist victims of violence against women in different care centers for this public in Aracaju and the interior of Sergipe. The five classes generated by the Descending Hierarchical Classification (DHC), generated by the Iramuteq analysis, pointed out five themes: care for women victims of violence, conflicts, violence and professional practice, authors of practice of aggression, personal self-care and handling obstacles in the work environment. In view of the results found, the strengthening of the public policy system is appointed as one of the pillars that reconfigure this reality.


The dependence of the extinction ratio on the angle of inclination between the end surfaces of electrooptic crystals with natural birefringence and on the light spot size is described in the electrooptic light modulators.


The decision support system for fleet planning and ship routing is developed by using the mixed programming technique with Visual Basic and Fortran based on a linear programming model.The design and implementation methods of the system function,architecture and algorithm are described.A tanker fleet of shipping company is taken as a case study to demonstrate the system performance.The implementation of the system shows that the system is stable,and it is able to obtain the optimal solution including ship allocation and fleet development exactly in a short time,which can be used to support the maker's decision.


The immune microenvironment of human tumors is highly complex and is composed of all populations of lymphoïd and myeloblastic cells. The immune contexture, which takes into account the density, location and functional orientation of immune cells, is a major prognostic factor for patient's survival. In most cancers, a strong infiltration of memory CD8 T cells and a Th1 correlates with longer survival of patients with primary or metastatic cancer. Howewer, the expression of immune check-point molecules, such as PD-1, LAG3, TIM3 on lymphocytes and of their ligands on tumor cells or myeloid cells greatly affect the progostic impact of the anti-tumor immune response. Tertiary Lymphoid Structures, similar to those found in auto-immune inflammed sites, are essential sites for shaping effective, or exhausted, anti-tumor immune reactions.The immune contexture,its buiding and its modulation will be discussed in the light of the exploding use of immune check point modulators in cancer, with consequences on auto-immune and inflammatory diseases. Disclosure of Interest W. Fridman Consultant for: SERVIER, LFB, SANOFI, PIERRE FABRE MEDICAMENT


PREVIOUSLY I WROTE ABOUT the excellent, creative work going on at the chapter level in NATS, and now I'd like to highlight a number of our exceptional national programs. Diverse offerings have something to offer the entire membership-whether you are a developing teacher, an experienced pedagogue, or a student of singing.Our National Conferences are held every two years and attract registrants and presenters from around the world. As the more than 950 people assembled at the recent Boston conference can attest, the schedule overflows with plenary and breakout sessions, exhibits, poster papers, competitions, performances, and social gatherings-all of which celebrate the art of singing, while being educational and inspiring. The conferences continue to expand in breadth and scope, and among recent new features are two additional singing competitions-the National Music Theater Competition and the annual National Student Auditions. Our next conference will be in Chicago, July 8-12, 2016.NATS National Workshops have long been dynamic continuing education events. Workshop programs gather around a central theme and offer in-depth exploration of the topic. Having organized and attended workshops, I can attest that these can be very vibrant affairs. Let me also remind you that the Vice President for Workshops is your elected officer, so don't be shy about sharing your ideas for future programming. The next workshop, which includes the finals of our National Student Auditions, will be held at the University of North Carolina at Greensboro, July 7-10, 2015.With the planning of conferences and workshops we are always mindful about varying the location, so that members periodically have closer access to events. No matter where they are held, however, these are ideal opportunities to expand your understanding of our art and to interact with teachers from throughout the Association. In addition, the NATS Live Learning Center, an electronic archive of videos from recent workshop and conference sessions, has recently launched. Be sure to visit it on the NATS website and return often as it grows.The International Congress of Voice Teachers is a worldwide gathering of voice teachers, very much like NATS National Conferences, but global in scope. These meetings have far-reaching impact, and I continue to hear inspiring accolades from the 2013 meeting in Brisbane. ICVT is held every four years in one of the member countries. The next meeting will be in Stockholm, Sweden, August 2-6, 2017.Perhaps a region and chapter resource more than a program, the Discretionary Fund is an important source of support, made available from national dues, to help facilitate special projects that might otherwise not be able to be offered. While the fund is not intended to be a primary source of support, and matching funds are typically required, the monies assist chapters and regions in sponsoring master classes, lectures, recitals, workshops, and other activities that enrich the professional life of students and teachers.Many people find the NATS Intern Program among the best things that NATS does. Generously supported by NATS and the NATS Foundation, the Intern Program is an exciting and innovative venture that pairs experienced and recognized master teachers with talented young members who have been teaching for no more than five years. The program combines a focus on supervised teaching with master classes, lectures, and demonstrations. …


This study identifies housing sub-markets (micro markets) that may be price leaders within local housing market areas and relates their performance to potentially relevant economic factors. This can be important as it provides both policy-makers and market players with a useful barometer regarding housing market behaviour. The study uses cointegration analysis to find those markets that interact with each other over the long run and isolates housing sub-markets that are not influenced by housing market behaviour elsewhere in the local urban economy. The study lays the basis for research aimed at identifying whether different housing markets respond to the same or to different economic stimuli. The research is likely to be of interest to policy-makers (such as town planners) as well as to developers and lending institutions.


Plutonium recycling in mixed-oxide (MOX) fuels loaded in light water reactors (LWRs) is economical, ecological, and in agreement with nuclear nonproliferation concerns. To date, more than 500 t of MOX has been loaded in 23 European reactors: MOX recycle is an industrial reality. Still a young and not a unique product, MOX fuel has a great potential for progress, in particular regarding its irradiation performances.


In this research, we try to understand Obsessive Compulsive Disorder (OCD) beyond its symptoms, as a way of planning different intervention strategies to help alleviate the suffering of patients. This disorder has a prevalence between 1.5% and 3% with variations in different cities. Despite its high prevalence, consultation levels are low since the disorder itself is associated with shame and fear, affecting a person's identity, the way the subject approaches the world and the life wished for. The reference frame adopted is the Suprapradigmatic Integrative Model, especially the functions of the Self proposed by this approach. The research is descriptive and aims to characterize the functions of the Self of patients with OCD. The sample is of 18 patients attended at a Psychological Services Center in Santiago, Chile, evaluated with the Integral Clinical Evaluation (FECI).


ABSTRACT Lung cancer has moved from the shadows of oncology to the forefront of drug development as it is now the cancer type for which the highest number of medicines are in development. Cancer genome testing is widely applied, and multiplexed analyses are performed because of the multitude of genetic aberrations which have targetable potential. Repeated tissue sampling is necessary to support treatment decisions upon resistance development, and liquid biopsies may prove valuable. All patients with adenocarcinoma or adenosquamous histology, as well as never-smokers of all histologies, should be tested for EGFR- and ALK-aberrations. KRAS-positivity may indicate the absence of other driver mutations and could be part of the initial diagnostic work-up in settings where multiplexed analyses are not yet available. Clinical trials with therapies targeting rare aberrations are abundant, and as many patients as possible should be offered therapy based on broad-spectrum cancer genome diagnostics.


IN MASSACHUSETTS, the Mental Health Clinic Association of Holyoke, Chicopee and Northampton Area, Inc., came into being in 1953 because, here as elsewhere, World War II brought about a greater familiarity with psychiatric concepts and an increasing understanding of the cost to the community of the problems arising from neglected emotional disorders. In the long period of preparation-more than 20 years-the concept of psychiatric social service for the tri-city area evolved from that of a small treatment unit, originally planned for Holyoke, to the nucleus of a mental health center serving a highly industrialized area of 160,000 and having infinite possibilities of further expansion. The concept of areawide service was realized through the leadership of the Junior League in Holyoke and with the cooperation of the Massachusetts State Departmient of Mental Health as well as many local professional and community leaders. Careful surveys of existing needs before the project became a set plan and a realistic approach to financing eventually demonstrated the values of an area plan of high professional standards.


Efficient heat transfer for compact electronic components has become a major need in these days. For this purpose, we require a minichannel heat sink with a liquid cooling system that makes these requirements as possible. In this work, both analytical and CFD investigations have been carried out to calculate the heat transfer performance of a minichannel heat sink consisting of cross sections with three different shapes of a rectangular, trapezoidal and hexagonal in which working fluid is made to flow. The simulation is conducted with water as the working fluid for three different shapes with Reynolds number ranging from 200 to 1000 and analyzed numerically for the single-phase laminar flow with the boundary condition of constant heat flux. The channel dimensions and inlet velocity effects on the Nusselt number, pressure drop, and heat transfer coefficient are studied. The 3D steady-state, laminar flow, and governing equations of heat transfer are solved using the finite volume method by commercial ICEM-Fluent software.


Trichoderma strain gz-2 is a potential biocontrol agent against Fusarium wilt of Saigon banana.The strain was identified as Trichoderma harzianum Rifai based on its morphological characteristics and sequence analysis of the internal transcribed spacer region of the ribosomal DNA(ITS).The biological characteristics of strain gz-2 were studied.The results showed that the growth rate and conidia number of the biocontrol strain were faster and more in PSA medium than those in other media.Sucrose and yeast extract were the optimum carbon source and nitrogen source for vegetative growth and sporulation,respectively.The optimum temperature for mycelium growth and conidial germination was 28-30 ℃,and the optimum pH value was 5.0-6.0.Light conditions had obvious influences on sporulations of the biocontrol strain.The results of pot experiment of strain gz-2 against Saigon banana Fusarium wilt indicated that the control effect of strain gz-2 against Saigon banana Fusarium wilt was best when solid strain gz-2 was used once in a week.The average control effect reached 74.4% 60 days after being inoculated with injured root.


FIELD: transport. SUBSTANCE: invention relates to automotive industry. Feeder of liquid reducing agent to exhaust gas cleaner comprises tank to contain said reducing agent and inlet into its inside. Injector is arranged in separate chamber at tank bottom. Pipeline connects said injector with said exhaust gas cleaner. Pipe extends through the tank bottom in the area of said separate chamber. Special cleaning ply covers the inlet. Mid space is arranged between inlet and said cleaning ply to accommodate at least one spongy element to absorb reducing agent for injector to withdraw said agent via inlet. EFFECT: reducing agent purification readily adapting to varying operating conditions, efficient use of said reducing agent. 9 cl, 4 dwg


Femtocell networks have emerged as a key technology in residential, office building or hotspot deployments that can significantly improve the coverage and performance of next-generation wireless networks. But, in the co-channel deployment scenarios, dense inter-femto interference might significantly deteriorate the overall system performance. In this paper, a new adaptive soft frequency reuse scheme in the dense femtocell networks is proposed where multiple dominant interference from dense femtocells is classified into a number of groups, and different frequency reuse factors and transmit powers for these groups are adjusted adaptively to mitigate the mutual interference. Simulation results show the proposed scheme yields great performance gains in terms of the spectrum efficiency relative to the legacy soft frequency reuse and universal frequency reuse.


545 Background: We performed gene expression analysis to identify molecular predictors of resistance to preoperative concomitant trastuzumab and T/FEC chemotherapy.

METHODS
Pretreatment fine needle aspirations from 21 patients with HER2 amplified, stages II-III breast cancer were available for transcriptional profiling with Affymetrix U133 A chips.

RESULTS
Overall pathologic complete response (pCR) rate was 71%. Age, nuclear grade, tumor size, nodal status or quantitative estrogen and HER2 receptor mRNA expression showed no association with response in univariate and multivariate logistic regression. We tested the accuracy of a 30-gene pCR predictor that was previously developed from patients who received T/FEC only preoperative chemotherapy. This predictor was accurate in validation in T/FEC treated patients (n=51) but showed low sensitivity in patients who also received trastuzumab (sensitivity 53% versus 92%). We could not identify any differentially expressed genes between pCR (n=15) and residual disease (RD, n=6) at a false discovery rate (FDR) <90% in the HER2 amplified trastuzumab-treated cases. Hierarchical clustering using the "Perou intrinsic gene set" also failed to separate pCR from RD. Gene Set Enrichment Analysis with 22 genes from trastuzumab-resistant cell lines showed a modest association with RD (FDR=9%).

CONCLUSIONS
Clinical variables and pharmacogenomic predictors that predict pCR in the absence of trastuzumab are no longer accurate when trastuzumab is included in the treatment. Trastuzumab-resistance associated genes identified in vitro are also associated with resistance in vivo. Support: Ellence Foundation. No significant financial relationships to disclose.


Objective Previous studies indicate that evening workers have increased risk of long-term sickness absence. The aim of the present study was to examine if evening work is associated with higher risk of sickness absence compared to daytime work. Methods The Danish Working Hour Database (DWHD) contains administrative payroll data from all Danish regions from 2007 to 2013. It includes 249,218 unique participants with 224,485,710 observations with starting and ending times for each worked shift and sickness absence on daily basis. For the present explorative study we selected all employees in a single hospital in 2009 (6,254 unique participants; 83% women; age: 40.8 years (SD = 11.9 years); 1,461,690 observations). The dataset was further restricted by excluding short (≤3 hours) and long (≥9 hours) shifts and observations with sickness absence or non-day/evening (e.g. night) shifts during the past 28 days. A sensitivity analysis with evening workers as their own controls, was carried out by excluding participants, who never worked evening. Evening work was defined as one or more evening shifts (≥3 hours between 18:00–23:00) during the past 28 days. The reference was dayshift (≥3 hours between 06:00–20:00). Using a multi-state model we analysed recurrent transitions between three states: work, sickness absence and temporary out of work e.g. holiday. Hazard ratios (HR) for sickness absence were calculated by Cox proportional hazards models adjusted for age and sex. Results Analyses showed that evening work was associated with lower risk of sickness absence (HR: 0.84, 95% CI: 0.73–0.96). The sensitivity analysis yielded similar results (HR: 0.87, 95% CI: 0.72–1.06). Conclusion When comparing periods with evening work to periods of day work the present study showed that evening work was associated with a decreased occurrence of sickness absence. This is in contrast to previous studies which compare evening workers with day workers.


We study adaptive fault-tolerant tracking control for uncertain linear systems. Based on recent results in funnel control, and the time-varying Byrnes–Isidori form, we develop a low-complexity model-free controller that achieves prescribed performance of the tracking error for any given sufficiently smooth reference signal. Within the considered system class, we allow for more inputs than outputs as long as a certain redundancy of the actuators is satisfied. An important role in the controller design is played by the controller weight matrix. This is a rectangular input transformation chosen such that in the resulting system, the zero dynamics, which are assumed to be uniformly exponentially stable, are independent of the new input. We illustrate the fault-tolerant funnel controller by an example of a linearized model for the lateral motion of a Boeing 737 aircraft.


At the present time the changes that take place in the systems of automatic
control are more and more notorious, it is so many of the factories, residences
and local commercial, they make use of these systems of automatic control
allowing a bigger efficiency and effectiveness in the moment of their application.
Not a long time ago the process of industrial control was carried out it with
electromechanical devices as contactores and reles like only control
implements. The problem of the reles and the contactores are that when the
production requirements change, he/she also makes it the control system. This
is expensive when the changes are frequent. Since the reles and contactores
are electromechanical devices that possess a certain lifespan, they require a
planned strict maintenance. On the other hand, in occasions they should be
carried out connections between several reles and contactores, what implies an
enormous design effort and maintenance.
The formless present has as purpose to develop the didactic guides so that the
students develop the necessary practices for the automation of a system of
motors trifasicos with turn investment under the control of a logical controllable
programmer.
The logical controllable programmer PLC has been implemented in the one that
to make industrial, allowing to control in form continues the speed of the motors
monofasicos and asynchronous trifasicos. Modern PLC is based on micro
controllers, in modules of power with automatic protection functions and in
intelligent control units.
In this context one can affirm that the present practical work, applied to the
control of motors trifasicos will contribute in the academic formation, the
students' of the Career of Technology tecnic, practical in Electricity and likewise
it serves from support to the Career of Electromechanical Engineering.


Impact of Medicare and Medicaid Beneficiaries with Selected Conditions on Emergency Department Utilization by John K. Amoh MBA, The George Washington University, 1998 BS, Albright College, 1994 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy


The traditional CAD methods have limitations in cartoon plush toy design,thus a sketch-based rapid design approach is introduced for 3D cartoon plush toy design.It realizes the 3D plush toy modeling by means of silhouette sketch-based drawing from a planar picture,which can rapidly and efficiently create as well as modify a 3D cartoon plush toy mesh from the sketched silhouette.


The study aims to determine the impact of team management and service operations flexibility on customer service. Service operations flexibility is divided into external flexibility and internal robustness. A mediation model is proposed that links team management to customer service via operation flexibility. Drawing on a sample of 475 of operations managers of various service sectors in Malaysia and South Africa, Structural Equation Modeling (SEM) was employed to test the relationship using SMART-PLS procedures. It was found that a significant relationship was established between team management to customer service via both operations flexibility dimensions. Theoretical and managerial implications are offered to explain the results.


To assess the effects of binge watching on ocular health. A short term (2 months) descriptive study was conducted on young adults aged 18 years - 26 years of a medical college of North India. Sample size was 492 participants. A pre-validated questionnaire was administered online to the participants collecting data on demographics, attitudes and practices of binge watching and ocular symptoms they experienced. Then they were subjected to ocular examination. Schirmer test 1 and tear break up time were conducted to diagnose dry eye. Data was compared between the two subsets of binge-watching and non-binge-watching, the association between binge-watching and observations were established by chi-square test. A total of 492 young adults participated in the study. Prevalence of binge-watching among the participants was 54.87%. A significant association was found between the use of streaming services and binge-watching (p-value = 0.002128). A significant association was found between binge-watching and discomfort in eyes (p-value = 0.008882), trouble sleeping (p-value = 0.003455), blurring of vision (p-value = 0.042263) and pain in neck and shoulder (p-value = 0.000042). The binge-watching subset was associated with dry eyes as found by Tear Breakup Time Test (TBUT) (OU p-value= <<0.01). The practice of binge-watching has a negative effect on ocular health.


Background and Aims: Nitric oxide plays an important role in the control of gastrointestinal motility. This study assessed the effects of graded doses of the nitric oxide‐releasing agent, nitroglycerine, on distal oesophageal motor activity and lower oesophageal sphincter resting pressure.


Relatively few studies exist in the literature that discuss the effects of diet on drug metabolism and how this can affect interindividual differences in systemic drug exposure. Several studies have investigated the effects of cruciferous vegetables (Cruciferae) or their constituents on drug‐metabolizing activity, as these vegetables form an important part of many peoples' diets. In general, the ingestion of cruciferous vegetables is associated with induction of cytochrome P450 (CYP) 1A2 activity in vivo; however, there is contention between reports, and the clinical significance of potential diet–drug interactions remains unclear. This study reports a systematic review, critical appraisal, and meta‐analysis of the published literature in this area, and discusses the clinical significance of Cruciferae‐enriched diets in the context of diet–drug interactions. Twenty‐three dietary intervention trials with drug metabolism end points were identified across Embase, Medline, and the Cochrane Controlled Register of Trials (CENTRAL). Cruciferous vegetables represented in the literature included broccoli, Brussels sprout, cabbage, cauliflower, radish, and watercress. A range of phase I and II drug‐metabolizing enzymes and phenotyping metrics were represented in the literature. The meta‐analyses performed demonstrated a significant effect on CYP1A2 and glutathione S‐transferase‐alpha (GST‐α), with consumption of Cruciferae increasing the activities of these enzymes by 20–40% and 15–35%, respectively. The results herein suggest that patients undergoing pharmacotherapy with CYP1A2 or GST‐α substrates could have altered drug exposure profiles if they regularly eat large or variable amounts of cruciferous vegetables. Recommendations regarding the design of future randomized, controlled trials to test hypotheses in this area are included.


Disinfection of water with chlorine plays a leading role in the protection of drinking water against pathogenic microorganisms and consequently the prevention against waterborne diseases. However, this disinfectant can also react with naturally occurring substances in water and which may pose a problem on the aesthetic or health plan. 1260 Hamza Nawel, Benyahia Mohamed, Moueddene Kada & Hamel Laïd The objective of this study carried out at Ain Temouchent city was to estimate the influence of residual chlorine on the organoleptic aspects of the drinking water, and that through a monthly sampling carried out on thirteen sampling points from subscribers of this locality during a period of one year. The determination of chlorine residual level was effected by the DPD method, while the estimate of taste and odor contained in the analyzed waters was based on the capacity of each taster to detect the presence or not of taste or smell. Our obtained results showed that the concentrations of residual chlorine in drinking water have certainly exceeded the prescribed standards and that was reflected clearly on taste and even smell of the same waters (with a noncompliance rate that corresponds to 53.84% for taste and 46.15% for the smell). Furthermore the statistical processing of our data with the principal component analysis, allowed us to confirm the existence of highly significant relationships between chlorine used as a disinfectant and the others parameters studied. This influence of chlorine making this drinking water unpleasant for the drink in some points encourages us to undertake practical actions to better improve the quality of water distributed.


In this article, we design a system that assembles two sources of energy (photovoltaic: main source, and the national electrical grid: emergency source) to power a DC load with a clean and optimized storage device. This assembly called in the literature hybrid system will allow us to ensure the supply of the load in all circumstances and to store the excess of the photovoltaic energy by a clean process in the form of hydrogen production. Efficient power management strategy (PMS) for the system was evaluated by examining its ability to meet the energy load requirements. The effectiveness of this management is manifested by the extreme use of energy. The electricity grid only intervenes as a last resort to fill the energy deficit. The simulation results show that the proposed hybrid system equipped with the different control algorithms is capable of supplying the energy required by the load and of storing the excess energy in the form of hydrogen production by an optimized electrolysis system controlled by a flow-meter.


T HE execution phase is the "active" phase of apoptosis occurring immediately after a cell commits to the death program. It lasts about an hour and is characterized by the hallmark morphologic features of apoptosis (e.g., membrane blebbing, chromatin condensation, and DNA fragmentation) culminating with disassembly and packaging of the cell for phagocytosis. Most studies of the execution phase have focused on elucidating nuclear events with the identification of important mechanisms responsible for nuclear execution such as the link between release of cytochrome c, activation of caspase 9/3, and DNA fragmentation (Li et al., 1997; Liu et al., 1997; Enari et al., 1998). Study of cytoplasmic or extranuclear events, on the other hand, has lagged. However, within the past two years, insights into underlying mechanisms and biochemical regulation have led to greatly increased interest in execution phase events occurring outside the nucleus. Despite the recent interest in the extranuclear execution phase, there has been no previous review of the literature, and, at first glance, the various studies appear relatively disparate. However, by subdividing the execution phase into three sequential phases, almost all the data obtained on extranuclear execution phase events can be organized into a relatively coherent paradigm (Fig. 1). In the model we propose, the first stage is release. As most cells enter the execution phase, they release extracellular matrix (ECM) 1 attachments and reorganize focal adhesions (FA), adopting a more "rounded" morphology. This outward change correlates with loss of stress fibers (if present) and a reorganization of actin into a peripheral (cortical), membrane-associated ring. Microtubule disassembly also occurs in this stage. The blebbing stage begins with myosin II–dependent contraction of the actin ring followed by a period of sustained, dynamic plasma membrane protrusion and retraction. It continues until finally the cell enters the condensation stage, which is characterized by condensation into small apoptotic bodies or into a single, shrunken ball, correlating with dissolution of polymerized actin. This article will review advances in extranuclear execution phase events within the context of these stages. The goal of the proposed organizational scheme is not to be all-inclusive but, rather, to offer a temporal and structural framework within which nonnuclear execution phase events can be classified.


Fisheries
The decline of fisheries is a story not just about fish, aquatic ecosystems, and sustainable food supplies but also about the people who base their livelihoods on fishing. Severe limitations imposed in recent years to maintain a sustainable cod fishery in the Northeastern United States have brought the catch to historic lows. Recognizing that fisheries management does not include any measure of the social impact of policy changes, Scyphers et al. surveyed the effect of the fisheries decline on people and communities. The results unveil severe psychological stress among fishing boat captains, exacerbated by ongoing lawsuits. Although trust for other fishers and the fishing business remains, low trust prevails for government bodies, fisheries management, and environmental nongovernmental organizations. The most distressed individuals were those without alternative income sources and with dependents at home.

Proc. Natl. Acad. Sci. U.S.A. 116 , 22912 (2019).


The purpose of this study was to compare the analytical results obtained for the volatile composition of baked wheat germ by simultaneous distillation extraction(SDE) and dynamic headspace extraction(DHE) coupled with GC-MS.A total of 101 volatile compounds were identified from baked wheat germ by both methods,including 15 aldehydes,8 alcohols,11 hydrocarbons,12 ketones,6 ester,5 phenols,10 acids,6 ethers and 28 nitrogen-containing heterocyclic compounds.Among them,aldehydes and nitrogen-containing heterocyclic compounds were identified as dominant volatile compounds responsible for the flavor of baked wheat germ.Great differences were observed among the peak areas of the same volatile compounds measured by both methods,but almost the same types of volatile compounds were identified from baked wheat germ,especially the critical aroma-active compounds.Therefore,similar results could be obtained for the composition of aromatic compounds by SDE/GC-MS and DHE/GC-MS.


The invention relates to an shrapnel of a voice coil motor. The shrapnel comprises a flat plate, wherein the center of the flat plate is provided with a through hole; and an outer frame and an inner frame which surround the through hole and at least two elastic parts which are positioned between the outer frame and the inner frame are arranged on the flat plate, the outer frame is provided with at least two adhesive application parts, and the adhesive application parts are provided with a plurality of adhesive application holes. The invention also relates to a voice coil motor provided with the shrapnel.


(1) The objectives in this paper should be examined by both Colleges with a view to accept¬ ance as joint training policy. (2) Since the present joint working party was established before the creation of the Royal College of Psychiatrists, that College should now be asked to create a formal co-ordinating committee with the Royal College of General Practitioners, with maximum possible powers to organise. (3) The Royal College of Psychiatrists, which is actively considering the training of new consultant psychiatrists, should bear in mind the needs of general-practice psychiatry for support and training. Its examiners for the MRC Psych. should also have these needs in mind.


Diabetes is a worldwide chronic metabolic disorder which can lead to poor quality of live and even death. Nowadays, herbal therapy is considered as an alternative therapy for diabetes. This study aimed to investigate the effect of Tinospora crispa aqueous extract (TCA) on elevated blood glucose in streptozotocin-induced diabetic rats. Diabetes mellitus was induced in Sprague-Dawley rats with streptozotocin (STZ) (50 mg/kg). The rats were divided into five groups (n=6), as follows : normal control(N), normal TCA treated(NT), diabetic control(D), diabetic TCA treated(DT), and diabetic treated with standard commercialized Vitamin E(DE) respectively. Intervention was given for four weeks and blood sample were withdrawn for measurement of fasting blood glucose. The data between groups were compared using one way ANOVA test, while paired T test was used to analyze those before and after treatment. Diabetic rats showed a significant increase in the blood glucose level after STZ induction (16.38+-0.54 mmol/dl) compared to the normal rats (4.98+-0.03mmol/dl;P<0.05). This elevated blood glucose remained steady till the end of study for group D and DE. The administration of TCA in DT group reduced the elevated levels of blood glucose in the 2nd,3rd and 4th weeks post-treatment considerable (P<0.05). In normal groups, there were no significant different between group N and NT before and after TCA administration. The body weight normally rose in normal groups compare to diabetic groups which slowly increased. In D and DE groups, the body weight decreased continuously started from the second week till the end of experiment. This study shows that Tinospora crispa aqueous extract may decrease elevated blood glucose level in streptozotocin induced diabetic rats and affect the body weight.


Laterality problems may be the cause of learning disabilities and difficulties in reading and writing. The objetive of this work is to check whether there is a relationship between the develop-ment of laterality, academic performance and literacy skills. To this end, laterality in 30 children from 3rd grade in Primary has been evaluated. After analyzing different test (Basic Movements test, Reversal test and writing and reading probe called TALE test) the results show differences in the scores. Children with right laterality have the highest scores in tests analyzed. Lower scores are observed in children with laterality problems, being children with cross lateral development who get the worst scores. Significant differences related to type of laterality and academic performance have not been found, although in relation to the raw score and rate of errors made, children with homogeneous right laterality development get better literacy performance. It's suggested a neurop-sychological intervention program to improve the laterality development in the children and to solve the difficulties in reading and writing detected in the evaluation.


Abstract The wood moisture sorption (WMS) isotherm is generally considered to contain information on the water-cell wall interaction and the abundance of water sorption sites (SSs) in wood. The Hailwood-Horrobin (HH) model – as an example of the multilayer surface sorption models – is discussed for its suitability to analyze experimental WMS isotherms, to elaborate the fundamental sorption parameters. Based on multiple independent experimental and theoretical arguments, it was concluded that the basics of the surface multilayer-sorption models do not apply to wood. This is clearly illustrated by applying the analysis to the temperature-dependence of WMS isotherms, to the comparison of adsorption vs. desorption isotherms and to the quantification of SSs in wood. A sorption site occupancy (SSO) model is presented as an alternative for the HH model. It provides a comprehensive, thermodynamically consistent and quantitative basis for the analysis of WMS isotherms. The predicted SS densities are realistic and can be used to quantify sorption hysteresis and cell wall relaxation.


Summary In this prospective study 100 consecutive patients underwent diagnostic cystoscopy as outpatients under clean but not sterile conditions and without the use of any chemotherapeutic or antibiotic coverage. The incidence of bacteriuria was negligible. The normal bladder can rid itself of infection by means of voiding and by its inherent antibacterial activity. It is concluded that operating room conditions and the use of prophylactic agents are not necessary in the prevention of urinary tract infections of the normal bladder undergoing simple cystoscopy.


The particular link that the leading chorus and the rest of the characters maintain with the theatrical space reveals the remarkable coherence between text and spectacle in the composition of the Suppliants of Aeschylus. On the one hand, the fact that actors and chorus share a single area in this drama, the orchestra, forces us to revise the organization of a space regularly dedicated to the chorus. On the other hand, the uninterrupted presence of the collective protagonist on the scene and the dynamics of arrivals and returns of the supporting characters encourage us to analize the somatic dimension of "spatial syntax", according to Ruth Padel's expression, considering the places that each character occupies during each conjuncture of the play. The aim of this article is to demonstrate that the dramatist altered and maximized the alternatives of use of the theatrical space in order to construct a dramatic space consistent with the redesign of the role of its available resources.