[Objective] The study aimed to provide the scientific basis for extension of Jijing 102 in large scale.[Method] The five factors quadratic regression orthogonal rotational combination design was taken to study the effects of 5 factors(N rate,P rate,K rate,sowing density and seedling number per hole) and 5 levels of each factor on the yield of Jijing 102.[Result] The effects of each factor on Jijing 102 showed as N rate P rate sowing density seedling number per hole K rate.The relationship between 5 cultivation factors and yield all showed a parabola type.The effect of N rate on yield was the most obvious.The N rate and seedling number per hole had a negative interaction.The simulated result showed that the highest yield of Jijing 102 was 10 896 kg/hm2.If the yield of Jijing 102 reached 10 500 kg/hm2,the N rate of 132-167 kg/hm2,P rate of 87-113 kg/hm2,K rate of 51-98 kg/hm2,sowing density of 30 cm×(13.9-19.4) cm and seedling number per hole of 2-4 plants were required.[Conclusion] The technical system of high yielding cultivation for Jijing 102 was established.


The article has introduced the outline of the legislation of China's measure of safety. It has put up with the weakness and offered some advices on its improvement.


Lung cancer also referred as lung carcinoma, is a disease which is malignant tumor leading to the uncontrolled cell growth in the lung tissue. About 90% of lung cancer is due to smoking. There are two major types of lung cancer: Non-small cell lung cancer (NSCLC) and Small cell lung cancer (SCLC). The most common type is the non-small cell lung cancer (NSCLC) which contributes 80-85% of lung cancer and small cell lung cancer (SCLC) which contributes 15-20% only. Hence for this reason, the early-stage lung cancer i.e. stages I and II are difficult to detect. Many people having lung cancer are diagnosed at stages III and IV. Doctors utilize some methods to diagnose lung tumor, for example: X-rays, CT Scan, PET scan etc..


Because the log information provides some critical clues for solving the problem of illegal system access, it is very important for a system administrator to gather and analyze the log data. In a Linux system, the syslog utility has been used to gather various kinds of log data. Unfortunately, there is a limitation that a system administrator should rely on the services only provided by the syslog utility. To overcome this limitation, this paper suggests a syslog agent that allows the system administrator to gather log information for file access that is not serviced by syslog utility. The basic concept of the suggested syslog agent is that after creating a FUSE, it stores the accessed information of the files under the directory on which FUSE has been mounted into the log file via syslog utility. To review its functional validity, a FUSE file system was implemented on Linux (Ubunt 14.04), and the log information of a file access was collected and confirmed.


Interest in the time allocation of household members in developing countries is of relatively recent origin. Demographic studies have provided the major impetus for the focus on time allocation as these studies have become increasingly concerned with the costs of caring for children and with the work of children. Efforts are also being made to adapt the general body of modern household economic theory to the low income rural setting. This paper reports an analysis of time allocation data collected from rural Philippine households as part of a larger research effort on agrarian household behavior. In the language of modern household economics, the time of household members is a resource or factor of production. For poor households, it represents the dominant household resource. It will be allocated to several activities in such a way as to minimize the cost of producing household goods. The first section of this paper develops a relatively simple analysis of factors determining time allocation of household members in rural households. The second section reports a simple econometric analysis of the Philippine data.


Amongst the various diseases on global scale, the second leading cause of mortality and morbidity is ischemic stroke due to the unavailability of an effective therapy. With the growing occurrence and its related health risks along with the absence of effective therapeutics, the ischemic stroke demands the continued and intensive research to explore the effective and safe therapeutics. These therapies may positively affect the numerous pathways associated with neuroprotection thus, extending the advantages to a larger population of stroke patients. Several preclinical studies employing neuroprotectants have shown promising outcomes, but failed in clinical trials either because of the lack of safety or efficacy. The blood brain barrier (BBB) restricts delivery of various potent neuroprotectants to the specific areas of the brain. The application of nanovehicles for delivery of drugs in the brain however, could revolutionize the treatment of ischemic stroke. These nanovehicles loaded with the drug could readily traverse the BBB via carrier, receptor and adsorptive-mediated endocytosis into the brain without compromising the integrity of BBB. Recent advances in neuronanotherapeutics have resulted in the improved neuronal regeneration and recovery after the ischemic stroke. In this review, we have attempted to discuss unexploited neuronanotherapeutics potentials to treat and manage ischemic stroke.


Contemporary concern for bricolage both transcends and supersedes de Certeau's important intervention that resituated the term as actions undertaken in everyday life. In particular, he engaged the notion of bricolage in ways that presented tactics, evasions, resistances, ruses and even tricks in his consideration of everyday life as practiced. Whilst these considerations may be read, as indeed he asserted, as 'making do', there are further possibilities of this term. For example, bricolage may be considered to 'occur'. In this we may take the anthropologist Hallam and Ingold's grasp of creativity as something in our bodily and mental response to situations, calm, anxious and otherwise; responding to the detail of a situation, a required or desired action.


There are obstacles in the Efforts to increase corn production , because the empirical condition of corn peasents in Lampung province currently hasan average productivity rate of 4.99tons/arce, below the potential productivity of 7-8tons/arce for the type of soil in Lampung Province. Corncultivation requires human resources (HR) who have entrepreneurial behavior as peasentsin addition toapply the knowledge and experiences in the techniques of cultivation and managerial behavior as well asareliablepeasent. Peasents who have apositive behavior make it asacreative and innovativepeasentasan entrepreneurinthe field of agriculture. Results ofthe studyfound that theperceptionof peasents onthe learningprocessineducationis influencedbyfactors: working motivation,  access to information, environmentalfarmingandentrepreneurialbehaviorinfluenced bypeasentsformaleducation, work motivation, access toinformation, environmentalfarming,  andperceptionsof peasentstowardsthe learningprocessinagriculture extension in South of Lampung.In order toenhance theentrepreneurialbehaviourof peasentscan be donethroughagricultural extensionmodels. Dids Link :  http://dids.info/didslink/06.2015-75466176/


The rise of digital technologies has significantly transformed the marketing landscape, presenting challenges and opportunities for businesses of all sizes. With the increasing prevalence of social media, mobile devices, and other digital channels, marketers must adapt their strategies to stay competitive and engage with customers meaningfully. This paper explores the various dimensions of digital marketing, including social media marketing, influencer marketing, content marketing, email marketing, and search engine optimization. Additionally, it examines the role of data analytics and the importance of developing a robust online presence. By synthesizing current research and real-world examples, this paper provides insights into the best practices and tactics for succeeding in the digital era. Ultimately, it highlights the need for marketers to stay agile and proactive in their digital marketing approach to achieve lasting success in today's dynamic business environment.


This article cites the ambiguous mathematics into the synthetical evaluation of how new the machine is,build up the ambiguous evaluating mathematic model.Based on all these,the detailed evaluating process is giving with an example.Practice testified reliability and rationality of machinery equipment's evaluation.


1Division of Anatomic Pathology, Vancouver General Hospital, Department of Pathology & Laboratory Medicine, University of British Columbia; 2Pezim Clinic; 3Department of Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia Correspondence: Dr Joyce M Leo, Division of Anatomic Pathology, Vancouver General Hospital, 910 West 10th Avenue, Vancouver, British Columbia V5Z 4E3. Telephone 604-875-4480, fax 604-875-4797, e-mail email@example.com Received for publication January 28, 2014. Accepted Febraury 7, 2014 CASE PRESENTATION A 79-year-old man presented with a 1.5-year history of a prolapsing cystic structure located within the anterior anal sphincter, clinically suggestive of a hemorrhoid. Physical examination demonstrated a cystic mass within the anterior anal verge, measuring up to 3 cm in maximum diameter. During the ensuing surgical procedure, the cystic structure was opened and contained thick purulent fluid; no solid areas were present. The microscopic appearance (Figure 1) was of a cyst partially lined with squamous and ciliated tall columnar epithelium (short arrows) containing occasional goblet cells (long arrows); there was no evidence of dysplastic epithelial changes. Subjacent scattered bundles of fibrous connective tissue and small blood vessels were present within the cyst wall. The histological features were consistent with a benign tailgut cyst.


The mass migration from German‐speaking lands after 1933 has led to huge research projects, but the fate of the refugees in Britain has for long been neglected. The focus in this article on Wilhelm Sternfeld reveals that his career was exemplary. As a German refugee escaping to London, like so many others, by way of Prague, he became involved in many of the London refugee organizations. After 1945 he helped produce the first bio‐bibliography of exile literature. Exile Studies have been slow to start in Britain, but now Sternfeld's example is being followed at the London Research Centre for Exile Studies.


32 PIC pigs,weighted 59.82±1.32 kg on average,were subjected randomly to 4 treatments for determining the effects of extrogenous metabolism-regulating agents on pig performance,protein turn-over and nitrogen retention by using isotope(15N-Gly) technique and nitrogen balance trial.The 4 treatments were:(1) basal diet;(2) basal diet plus cysteamine(70mg/kg,CS group);(3) basal diet plus non-stable astragalus extracts 250mg/kg(NCAE group);(4) basal diet plus stably astragalus extracts 250mg/kg(CAE group).Astragalus extracts and cysteamine,especially NCAE,redounded to increase pig performance,especially increase average day gain(P0.05).Both astragalus extracts and cysteamine accelerated protein aggradation rate and amino acid utilization rate,as well as biological value.Astragalus extracts helped to accelerate the synthesis rate of amino acid into body protein and reduce the excretion rate of endogenous urine nitrogen.The mechanism of increasing protein deposition of cysteamine is reducing body protein degradation rate(26.71% reduction,compared to control group),while that of astragalus extracts is bilateral,reducing protein degradation rate(24.84% and 3.66% reduction for NCAE and CAE) and accelerating protein synthesis rate(22.86% and 19.18% increase for NCAE and CAE).Both astragalus extracts and cysteamine contributed the increasing nitrogen retention,net nitrogen utilization and biological value.


2,3,8,9-Tetramethoxydibenzo[c,e][1,2]dithiin ("dithiobiphenyl" = "DTB") forms a host lattice for iodine. Electron transfer from DTB to iodine leads to the formation of an organic semiconductor with the approximate formula of DTB·I1.16. This host−guest complex can be prepared either by cocrystallization of both compounds from solution or by treating solid DTB with gaseous iodine. Upon heating, iodine is released again. Both intercalation and deintercalation were studied with physicochemical methods, among them thermal analysis, electron paramagnetic resonance (EPR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and thermomicroscopy.


1. Carnosine and anserine have been measured in samples of breast and leg muscles from three turkeys. 2. The results show that there is a large difference in the dipeptide content between the two types of muscle.


In this paper I discuss the concept of social asymmetry as a relation between the individual and society, but also as an intrinsic characteristic of society. I intend to analyze the relevance of the term to the fields of political science (descriptive, factually committed) and to political philosophy (normative, concerned with the difference between individuals with different values and options, the way in which factuality is regulated by the type of society).The term social asymmetry may be relevant in social ethics, as dependent on factors such as justice, freedom, truth, law, quality of life, etc. The present study highlights two types of social asymmetry: an irreversible one, one of totalitarian societies, and another, a reversible one, inherent in democratic societies.I consider that social asymmetry was at the basis of political upheaval in the communist bloc of the nineties. The balance of any society is ontological, meta-social, centered on the human person. The ontological dimension seen as an existential equilibrium among a multitude of non-quantifiable parameters is the one that sorts the type of society and determines its type of asymmetry.


The constitutive meeting of the EPS Advisory Committee on Physics Edu cation was held in Bucharest on 11 September 1975 in the presence of 26 members and delegates from EPS National Societies and other Educa tional Institutions. The chairman outlined the back ground to the formation of the Advi sory Committee. In many areas, the problems arising from changes in the educational pattern, such as the intro duction of new mathematics courses and of integrated science, have led to some disorientation of physics tea chers, especially at the secondary school level. Changes such as these have led to difficulties in the teaching of basic physics. Perhaps even more serious are the consequences of a science teaching at the most elemen tary school level that neglect the role of physics in understanding natural phe nomena and overestimates e.g. that of biology. The chairman reported briefly on the International Conference on Physics Education held in Edinburgh last summer. A well defined activity programme could of course not yet be formulated in this first meeting. A number of points, however, were made during the general discussion on possible acti vities of the Advisory Committee. In particular, it was suggested that we attempt to identify problems which the Committee, through its European cha racter, is in an especially strong posi tion to study. Accordingly, the first task of the committee should be to assemble in formation on the curricula in different European countries. At the next meeting (planned for Monday 5 April 1976 in Leipzig), mem bers will be asked to present papers giving a description of the physics teaching in their own countries at se condary school level (to begin with). The hard data, concerning e.g. cur ricula, should be complemented by more general information about the school system and the intended goals of the physics teaching programme. Furthermore the committee should become a channel of information, both inside and outside the European Phy sical Society, on activities in the field of Physics Education, leading in par ticular to the possibility of coordina tion of national efforts in the field. It was agreed to collaborate with the Advisory Committee on Publica tions for questions connected with journals on physics education : two de legates accepted to assist professor Depireux's committee. Professor Hea vens has been so kind as to act as se cretary for this meeting. Part of this report is based on his minutes.


This paper presents a simple algorithm for the calibration of antenna arrays. It belongs to the phase-less algorithms family, because it does not require the expensive phase measurement equipment. The estimation and compensation of the complex-valued gains of the array channels, caused by non-identical characteristics of these channels, is the aim of a calibration task. For the estimation, the considered calibration algorithm uses only three measurements of the array output power under 0°, 90° and 270° phase shifter states in each channel. The algorithm explanation and the main steps of the algorithm development, based on the geometrical representation of the antenna array signals, are presented. The algorithm efficiency is proved via simulation.


The Changjiang (Yangtze) River basin involves one fifth of the total area of China and one fourth of the area under cultivation. According to 1985 statistics, the volume of freight transported in the basin constituted about 80% of all inland waterborne transport in China. This article looks at the present situation and discusses what solutions are needed to current problems. Amoung these problems are the conflict between navigational needs and those for hydroelectric power, and the conflict between rail and water transportation. New ship forms for inland transport are then considered and prospects for the future are weighed.


The inflammatory cytokine tumor necrosis factor a (TNF-a) has been shown to stimulate human immunodeficiency virus type 1 (HIV-1) replication in both chronically and acutely infected T lymphocytes and monocytes. Transcriptional activation of the HIV long terminal repeat and subsequent increase in virus production are linked to TNF activation of the cellular transcription factor NF-KB. Here we report the use of two forms of soluble recombinant type 1 (p8O) TNF receptor to inhibit TNF-induced HIV activation in vitro. One receptor form is a monomer containing the entire 236 residues of the extracellular (ligand-binding) portion of p80. A second receptor form is a chimeric homodimer containing these residues fused to a truncated human IgGl immunoglobulin heavy chain and, thus, resembles a bivalent antibody without light chains. These recombinant receptor proteins were tested for their ability to inhibit TNF-a-induced expression of HIV-1 in chronically infected human celi lines. We also examined the ability of the soluble receptors to limit the activation of the HIV-long terminal repeat transcription. The soluble TNF receptor dimer was most effective at blocking TNF-a-induced HIV-1 expression in both monocytoid and lymphoid celis. The molar ratio of TNF-receptor dimer to TNF-a found to be most effective was, at least, 5:1. We conclude that at specific TNF/soluble TNF-receptor dimer ratios, TNF-a-induced HIV-1 transcription and expression can be limited in vitro. Human immunodeficiency virus (HIV) expression is concurrent with both lymphocytic and monocytic activation, both of which require the participation of cytokines (1-4). For these reasons, extensive research has been conducted investigating the role of cytokines in the amplification or inhibition ofHIV expression in lymphocytic and monocytic cell lines. Among the many cytokines tested, tumor necrosis factor (TNF) appears to be the principal cytokine that can amplify HIV expression in human lymphocyte and monocyte cell lines (3-5). TNF-a, classically characterized as the product of activated macrophages, is a highly pleiotropic cytokine that plays a central role in mediating the inflammatory response to injury and infection (6-8). Activities of TNF-a include cytotoxic and cytostatic effects against tumors and virusinfected cells, stimulation of interleukin (IL) 1 secretion, and activation of various immune effector cells. The biologically active form of TNF-a is a homotrimer (9, 10). Chronic TNF production has been implicated in cachexia; acute TNF production appears to be involved in the pathogenesis of septic shock and endotoxin-induced tissue injury. TNF is produced by phagocytic and nonphagocytic cells in response The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact. to endotoxin, IL-1, IL-6, and TNF itself (11). TNF biosynthesis is tightly regulated by both transcriptional and posttranscriptional mechanisms (11-14). TNF gene transcription is not only regulated by NF-KB binding but can induce NF-KB in both T cells and monocytes, thus providing one signal for HIV activation in virus-infected cells. The biological response of TNF is mediated through cellsurface receptors, two forms ofwhich have been molecularly cloned (15-19). These two forms share striking sequence homology in their extracellular domains and bind both TNF-a and TNF-,f with similar affinities. Two recombinant soluble forms ofthe type I TNF receptor (TNF-R) have been recently described (19, 20). One form, a monomer (mTNF-R1), contains all 236 extracellular residues and binds TNF-a with a Kd of 5 nM. A second form is a chimeric homodimer composed of the 236-amino acid extracellular residues fused to a human IgG Fc region. This soluble receptor (FcTNF-R1) binds TNF-a and TNF-jB with, at least, 50-fold greater affinity than the monomeric form. Naturally occurring soluble forms of type I and type II TNF-Rs have been found in human urine and sera and have been shown to be proteolytic cleavage products of the extracellular portions (20). These naturally occurring soluble receptors appear to bind TNF-a with affinities similar to the recombinant p80 monomer. In normal individuals, circulating serum levels of soluble TNF-Rs are -1-2 ng/ml (21-23). These levels are elevated in individuals in response to infection and some types of cancer (24). Engelmann et al. (25) showed that the soluble receptor can block the toxicity of TNF. A more recent study done in mice demonstrated that a recombinant soluble TNF-R could protect mice from the lethal effects of endotoxemia (26, 27). Various studies ofTNF-a levels in HIV patients have shown an increase in TNF-a levels during the early stages ofthe viral infection (22). A study of the acid-labile interferon a found in AIDS patients shows that this form of interferon can induce TNF-R (23). Our own studies are focused on the ability of recombinant, soluble p80 TNF-Rs to block the TNFmediated induction of HIV expression in vitro. MATERIALS AND METHODS Reagents. Recombinant human TNF-a was supplied by the Biological Response Modifiers Program repository (Genentech). Soluble recombinant chimeric FcTNF-Rl and soluble Abbreviations: HIV-1, human immunodeficiency virus type 1; TNF, tumor necrosis factor; TNF-R, TNF receptor; mTNF-R1, monomeric type 1 TNF-R containing entire 236 extracellular residues; FcTNF-R1, homodimer of 236 extracellular residues of type 1 TNF-R fused to IgG Fc region; RT, reverse transcriptase; CAT, chloramphenicol acetyltransferase; LTR, long terminal repeat; IL, interleukin. $To whom reprint requests should be addressed.


Objective To establish a reversed phase high performance liquid chromatography( RP-HPLC) to determine ursodeoxycholic acid,chenodeoxycholic acid,cholic acid and lithocholic acid in compound ursodeoxycholic acid capsules. Methods Diamonsil C18chromatographic column( 200 mm × 4. 6 mm,5 μm) w as used in the study,mobile phase w as acetonitrile-0. 03 mol·L- 1of phosphate solution( V ∶ V = 40 ∶ 60),the flow rate w as 1. 4 mL·min- 1,the detection wavelength was set at 205 nm,the column temperature was 35 ℃. Results Ursodeoxycholic acid,chenodeoxycholic acid,cholic acid and lithocholic acid w ere completely separated w ithin 25 min. A good linear range of 0. 80- 200. 00 mg·L- 1for ursodeoxycholic acid,0. 45-110. 00 mg·L- 1for cholic acid,0. 30-70. 00 mg·L- 1for chenodeoxycholic acid and 0. 30- 80. 00 mg·L- 1 for lithocholic acid w ere show ed respectively. The average recoveries of ursodeoxycholic acid,cholic acid, chenodeoxycholic acid and lithocholic acid w ere 99. 7%( RSD = 1. 30%),99. 3%( RSD = 1. 47%),98. 7%( RSD =1. 87%) and 99. 1%( RSD =1. 30%) respectively( n =12). Conclusions This method can simultaneously determine ursodeoxycholic acid,chenodeoxycholic acid,cholic acid and lithocholic acid contents in compound ursodeoxycholic acid capsules. The method is simple,accurate and reliable,and can be applied for the quality control of the compound ursodeoxycholic acid capsule.


This paper is a continuation of our previous paper [6], in which we treated modular equation n (X, j) in case n is a prime. Now we consider the case n is composite. By using resultant we can calculate them up to n = 56 and a few more. Also we include a detailed account of our computer program. 1 Modular equation n(X,j) Let z be a point in the upper half complex plane, and set q = eZ1riz • Then the basic elliptic modular function j(z) is of the form j (z) = 1/q + Co +Cl q +Cz qZ +... , where Co = 744, Cl = 196884, Cz = 21493760, .... Classically, j(z) plays a very important role in complex multplication theory. Even in recent years, j(z) has been the object of intensive study. (See a survey article by M.Kaneko [9]). For example, the finite simple group called Monster has some mysterious connection with j(z). In my previous paper [6], we consider the problem of explicit computation of the modular equation p(X,j(z)), which represents algebraic relation between j(z) and j(pz) (p is a prime) and discovered some curious congruences among coefficients of modular equation provided that the p are the Monster primes. Soon afterwards M.Kaneko [8] gives a theoretical explanation of that facts. By now we have computed the prime case of p(X,j) up to p = 73 (for 59::; p::; 73 on machine NEC 4800/660, 596MIPS, with 512MB memory of Akita University Information Processing center). 2 The case n is composite Now we consider n(X,j), n composite. Classically there is a formula given in Weber's book [12], p.242. (1) If (nl,nz) = 1 then ,p(nl ) nl n2(X,j) = IT n2(X,~i), i=l where the ~i are the roots of nl (X,j) = O.


The Organic-Conventional Comparative Dairy Systems trial at Massey University began in August 2001, and the organic farm achieved certification in August 2003. In general, the results of the first two years of the trial showed little difference in productivity, animal health, and soil and herbage quality between the two farms. The conventional and "in conversion" organic farms produced similar amounts of milksolids per cow and per hectare, and somatic cell counts were low for both herds. During the third season, which was a very good dairy season in the Manawatu, the organic farmlet consistently grew slightly less pasture than did the conventional farmlet and consequently produced less milk (15% less per cow and 19% less per hectare). These production differences continued in the fourth season (2004-05), which was characterised by a cool wet spring and early summer followed by a warm and dry late summer-autumn period, resulting in reduced pasture growth and milk production levels from the previous season. The 2005-06 season began well with excellent early spring conditions, but began to deteriorate in October with more variable conditions, and a prolonged summer dry spell meant an early dry-off in March for the organic herd, resulting marked differences in production between the two herds.


Direct product of a permutation strongly connected automaton and a synchronizing strongly connected Aleshin Type automaton is also a strongly connected automaton. An automaton is called quasi-ideal  automaton if and only if all the following conditions are satisfied; (i) It is strongly connected (ii) the minimal ideal of its transition semi group is a right group (iii) the ranges of the idempotent elements of the minimal ideal of its transition group form a merging of a partition on its set of states. An automaton is isomorphic to the direct product of a permutation strongly connected automaton and synchronizing strongly connected Aleshin type automaton if and only if it is a quasi ideal automaton.


Background/problem/issueSwedish ice hockey is by tradition built on the principles of the European Model of Sport (pyramid structure, non-profit, utility maximization, youth fostering, and promotio ...


this paper unfolds several problems on the basis of research retrospection and gives the checkout with the mutual data.The outcome is as following:there is fail to report not only in female but also in male;there is no corresponding connection between Chinese total population sexual ratio and sexual ratio at birth according to the data of 1949 and from then on;to enlarge the difference of marriage age can′t put off the marriage unbalance;preference of son is not only the problem of culture but also the fact of social structure;the policy of one kid is confronted with test;there is some technologies which we must cost to confront in investigation and census.


Scheduling appears frequently in distributed, cloud and high-performance computing, as well as in embedded systems. Here, the execution time of subtasks is the major factor influencing decision-making, and despite being random variables they are majorly treated in the literature as being deterministic. Our project intends to shed more light on the underlying distribution of execution times, attempting to verify: 1) if the usual assumption of normal distribution is reasonable; 2) if there exist more suitable distribution families; and 3) if anything can be inferred a priori by analyzing general aspects of the program. We have modeled the problem and experimentally assessed distributions, showing that they are often not normal. We suggest alternative distributions, which we released as R packages, and propose estimators that ease parameter inference. With this we hope to promote usage of stochastic scheduling by making it easier for users to define distributions when requested.


Orson Scott Card's Pastwatch: The Redemption of Christopher Columbus is an interesting work of fiction that belongs to the genre of Alternate History, which is a subgenre of speculative fiction. The novel poses the question of: "what would have happened to the world if the Indigenous American tribes had been stronger and had made coalitions with each other, instead of being conquered and defeated by European forces?" This paper reads the selected novel from the Ecofeminist point of view, exploring various issues that are relevant to the theory of Ecofeminism. The analysis conducted in this paper tackles the roles women perform when trying to save their world; the connections between women and nature, and how patriarchal cultures treat both of them; the role technology plays in the times of natural disasters and how it can make the world a better place for women; whether or not technology is a tool in the hands of the White savior; and the empowerment of the Indigenous Americans or lack thereof.


Fifteen species of shore flies, nearly doubling the number of known fauna, are reported from the Galapagos Islands. Of the 15 species, all but 2 are widespread in the Neotropics and apparently arrived on the Galapagos as introductions, which were probably independent events. The 2 apparent endemics, Philygria galapagensis Wirth and Scatella galapagensis Curran, may have speciated on these islands. The shore-fly fauna is disharmonic biogeographically, with only 11 of 20 tribes being represented. Ephydra gilvipes Coquillett (new synonym) is conspecific with E. chilensis Macquart, the senior synonym. A lectotype for Paralimna decipiens Loew is designated.


Fourty rats were divided in two groups as experiment (group A1, A2) and control (group B1, B2) groups. After a laparatomy was performed on , a 1 gr/kg dose of 5% DMSO was administered to groups A1 and A2. In order to cause ischemia portal veins, hepatic artery and bile ducts were clamped for an hour. The animals were sacrificed either on the 2nd (groups A1 and B1) or on the 14th ( groups A2 and B2) days and livers were taken out as a whole for pathological examination. Blood samples were drawn to determine the serum levels of SGOT, SGPT, LDH, and AP.


Objectives:We retrospectively investigated the efficacy and tolerability of risperidone monotherapy in subjects with autism spectrum disorder (ASD). In addition, we did mixed effect model analysis of the effects of risperidone in patients with ASDs naturalistically treated in a routine clinical setting to determine whether the clinical effects were maintained and the side effects were tolerable. Methods:This retrospective study assessed children and adolescents with ASD, who were on risperidone monotherapy from July 2010 to July 2011 at the Child and Adolescent ASD Clinic at Seoul National Hospital. Outcome measures included the Clinical Global Impression-Severity of Illness (CGI-S) and the CGI-Improvement (CGI-I) scales along with other clinical indices: dosage, target symptoms, and side effects. Results:The mean dose of risperidone in 47 children and adolescents with ASD (40 males, 7 females; age range 5–19 years) who were on risperidone monotherapy was 1.6±0.8 mg/day, and the mean duration of the treatment period was 20.2±17.3 months. Aggressive behavior, stereotypic behavior, irritability, and self-injurious behavior were the most frequent target symptoms of risperidone. The most common side effects were weight gain followed by somnolence and extrapyramidal symptoms. In a mixed effects model analysis of CGI-I scores, the mean CGI-I score at the 1 month follow-up was significantly different from the mean CGI-I score of the 3-month follow-up (p=.046), and the CGI-I scores were equally maintained over 3 to 48 months [F(6, 28.9)=4.393, p=.003]. Of the 47 patients, 33 patients (70.2%) were identified as the response group, showing an end point CGI-I rating of 3 or under and having continued risperidone treatment for at least 6 months. The baseline CGI-S score showed significant association with clinical response to risperidone (p=.005), the mean baseline CGI-S was higher in the response group compared to the non-response group. Conclusion:In this study, clinical improvement of risperidone stabilized around 3 months and was equally maintained up to 48 months with tolerable side effects, supporting maintenance of risperidone treatment in children and adolescents with ASDs.


When elastic solids are sheared, a nonlinear effect named after Poynting gives rise to normal stresses or changes in volume. We provide a novel relation between the Poynting effect and the microscopic Grüneisen parameter, which quantifies how stretching shifts vibrational modes. By applying this relation to random spring networks, a minimal model for, e.g., biopolymer gels and solid foams, we find that networks contract or develop tension because they vibrate faster when stretched. The amplitude of the Poynting effect is sensitive to the network's linear elastic moduli, which can be tuned via its preparation protocol and connectivity. Finally, we show that the Poynting effect can be used to predict the finite strain scale where the material stiffens under shear.


How do you communicate clearly to a reader without boring him? How do you prod his imagination without confusing him? The answer, I suppose, is to be a highly skilled writer and work very hard at your craft. But while there may be no simple and absolute rules for effective communication, there is an art called rhetoric that can help. I offer the following brief passage from Aristotle's words about rhetoric in the hope that some who are unfamiliar with that ancient art may be moved to read further. A good starting point would be Readings in Classical Rhetoric, edited by Thomas W. Benson and Michael H. Prosser (Bloomington: Indiana University Press, 1969). As you read, bear in mind that this is a translation from a Greek text thought by scholars to be lecture notes – perhaps those of Aristotle himself, perhaps those of one of his students. Consider whether notes from any lectures you have given or attended are likely to look this insightful and clear 2300 years hence. Then notice Aristotle's very subtle understanding of how verbal style can shape an audience's awareness of what is being communicated.


Fossil pollen of Diporites aspis Pockna}l & Mildenhall, from the early Miocene of New Zealand, was examined by combined light, scanning, and transmission electron microscopy, in order to determine its relationship to extant Fuchsia pollen. Based on overall morphology, exine structure, exine surface sculpture, viscin thread morphology, and apertural features, the fossil pollen definitely can be considered to represent Fuchsia. Parallel studies of extant Fuchsia pollen indicate that a more precise identification of the fossils is not possible. With the examination of additional fossil material, it should be possible to learn a great deal about the timing of origin and migration of the genus Fuchsia, but not of its constituent parts.


Science、democracy and legality are the main factors in constructing the harmonious socialist society."Science and technology is the primary productive force".The base of constructing the harmonious socialist society will not exist without the progress of science and the development of economic.Democracy means people have right to deal with the business.Only under the socialist democracy,the contradiction which appeared in the process of developing theeconomic and society can be e- liminated and people's enthusiasm can be aroused,political stability can cast in the country.Legality is a forceful tool to imple- ment the democratic policy.People's right will not be ensured without it.These three emphasis are the premise of contructing the harmonious socialist society.


The velocity of the first plasma sheet was determined between the electrodes of a pulsed plasma thruster using three measurement techniques: time of flight probe, high speed camera and magnetic field probe. Further, for time of flight probe and magnetic field probe, it was possible to determine the velocity distribution along the electrodes, as the plasma sheet is accelerated. The results from all three techniques are shown, and are compared for one thruster geometry.


Genetic loss-of-function methods including short-hairpin RNAs (shRNAs) and CRISPR are key methods for target gene validation across a variety of different disease areas. While these methods have revolutionized target gene discovery and characterization, both methods suffer from limitations in the context of in vivo target validation due to off-target effects and insufficient knock-down for shRNAs and resistant clones for CRISPR. In this study, we describe a method, artificial RNA interference (ARTi) that overcomes these limitations by fundamentally changing the basic experimental strategy of RNAi-based loss-of-function studies. Instead of newly designing gene-specific shRNA for individual target genes, ARTi utilizes ultra-effective and selective artificial miRNA-based shRNAs that do not match any transcribed gene in the target genome. In addition, these sequences are optimized for ultra-efficient miRNA processing and knockdown of synthetic target genes, and are deeply characterized to not trigger major off-target effects, enabling highly stringent target validation in vivo with unprecedented temporal control, selectivity and potency. We validate the approach by studying the in vitro and in vivo phenotypes of EGFR, KRAS and STAG1, genes relevant to cancer biology. This loss-of-function strategy will enable novel experimental strategies in therapeutic target validation and will be instrumental in guiding the lead optimization process by establishing genetic benchmark phenotypes.
 Citation Format: Ralph Neumüller, Thomas Hoffmann, Alexandra Hörmann, Maja Corcokovic, Johannes Zuber. Precision RNAi using synthetic shRNAmir target sites. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3973.


Objective:To investigate the modulating effects of anti-epidermal growth factor monoclonal antibody Cetux- imab(C225)on the ehemosensitivity and radiosensitivity in a Docetaxel-resistant human lung adenocarcinoma cell line SPC-A-1/doeetaxel.Methods:Radiosensitivity of SPC-A-1/docetaxel was determined by clone formation experiment and quantified by calculating the enhancement ratio(ER).The growth inhibition of SPC-A-1/docetaxel cell line caused by C225 or combination of C225 and Docetaxel in different orders was detected by MTT assay.The effect of C225 on cell cy- cle distribution and apoptosis was determined by flow cytometry.Results:C225 combined with radiation significantly de- creased the number of the cell clones than radiation alone;the D_0 values were 1.73 Gy for the former and 2.39 Gy for the latter,and the enhancement ratio was 1.38.C225 alone at concentration up to 1000μg/ml for 48h had neither cytotoxic nor eytostatie effect on SPC-A-1/docetaxel in vitro.C225 administration followed by Docetaxel significantly decreased the ICw of Docetaxel(85.2μg/ml vs 128.7μg/ml).Flow cytometry demonstrated that C225 exposure induced apoptosis of SPC-A-1/docetaxel cells in a time-dependent manner.The cell in the G_0/G_1 fraction increased from(43.80±4.46)% to (60.50±6.57)%(P0.05)after a 24 h C225 exposure.Conclusion:C225 can enhance the radiosensitivity and che- mosensitivity of the Docetaxel-resistant lung adenocarcinoma cell line SPC-A-1/docetacel,which may be associated with apoptosis induction and cell cycle arrest at G1 phase.


Two different free‐air gravity datasets from the Apennines have been analysed in the frequency domain to investigate the mechanisms of support of topography. At short wavelength (λ<150 km) the best fit between the observed and the calculated admittance gives a value of the elastic thickness of 3.7 km. The observed behaviour of the admittance at larger wavelengths (λ>150 km) shows that such topography is not supported by elastic stresses in the lithosphere but is dynamically supported by mantle convection. The distribution of gravity anomalies and topography suggests that the mantle is rising beneath the main topographic bulge of the Apennines and that this flow is maintained by buoyancy forces, rather than being driven by movement of the subducted slab.


Reading the strophes of Meinloh von Sevelingen in the form as they have been handed down, one can scarcely resist the impression of their telling a story. The article seeks to highlight the basis upon which the supposition of Minnesang being indeed narratively composed makes sense and the circumstances under which such a composition is likely. It is possible, under the present supposition, to show that Meinloh's strophes in their cyclical order are to be situated in the 13th century as a work of collectors and manuscript-editors. The narrative tendencies turn out to be a phenomenon of reception, a form of ›Konkretisierung‹ typical of the period.


Camper is one of Spain's most well-known brands in and outside of the country. Throughout its 30-year history, Camper has been known for its innovative footwear designs, its in-store ambience and its emphasis on giving the customer a superior buying experience. As of 2005, it is facing increasing competition from multinationals such as Nike. The case outlines how the unique philosophy of the founder has brought creativity and imagination to the business and what the management team can do to maintain the company's success in the face of more intense competition from much larger competitors. A Spanish version of the case is also available. A teaching note in English is available for instructors.


In this study, the Technical Efficiency and the Allocative Efficiency Scores of 23 commercial banks operating in Turkey between 2003 and 2012 were obtained by use of the Data Envelopment Analysis. In the CCR model analysis; while 3 banks did not have Technical Efficiency for the first years, this number doubles for 2012. Whereas only 5 banks were efficient in terms of Allocative Efficiency for the first year, this number goes down to 4 in the last year. As a result of the BCC model; while only one bank did not have Technical Efficiency at the beginning of the period, this number quadruples at the end of the period. This number for the Allocative Efficiency is 10 at the beginning of the period and 16 at the end of the period. Considering the CCR model, it is more significant in the estimation by using the panel data regression model in order to determine the effect of the outputs on the efficiency of the banks. The Malmquist Index is used for the Total Factor Productivity and it was found out that the productivity increased only at the rate of two thousandth (0.002) for all the enterprises for the period.


The Greenwood and Williamson microcontact model of rough surfaces is modified to include the presence of a surface layer which is stiffer and harder than the substrate. The axisymmetric contact between a rigid spherical asperity and an elastic layered halfspace is analyzed numerically and correction factors for the contact area, load and the maximum von Mises stress are approximated to a closed form by using curve fits of the numerical results. The correction factors for the contact area and load are applied to the GW model to reflect the effect of the finite layer thickness and the substrate material. The correction factor for the maximum von Mises stress is used to calculate the plasticity index for layered surfaces. Parametric calculation of the ratio of plastic contact area to real contact area is carried out for a TiN-coated steel surface. The modified GW model is compared with a more rigorous real surface model and the validity of the present model is discussed. When the layer thickness is sufficiently large, the influence of the soft substrate can be neglected. A simple criterion for realizing the contact free of the effect of the substrate is proposed.


Polyaniline (PANI)/ graphene composite on cotton fabric were prepared by a combination of in situ polymerization and solution process. In order to prepare PANI/graphene was initially grafted to graphene oxide via solution process where a concomitant reduction of GO occurred due to the hydrothermally and exposure of GO to KOH. The study was designed in order to have a clear understanding of the role of PANI as well as modified composite thereof under investigation. The structural, morphological, optical, and electrical properties of these fabrics have been studied. Nanostructured PANI/ graphene composite fabric was enhanced UV shielding the value of 447. It is found that the PANI/ graphene composite fabrics are increased electrical conductivity. The thermopower value of the PANI/ graphene composite fabric could reach 0.045 μVK. Such materials are anticipated to be worthwhile for wearable electronic devices and as protective textiles.


Simple Summary Lymphoma is one of the most frequently diagnosed malignancies in dogs. The most common epigenetic alteration is gene methylation. Methylation of the p16 gene leads to decreased expression of its protein. The p16 protein inhibits the activity of cyclin-dependent kinase, as a negative control of the cell cycle to prevent phosphorylation of the retinoblastoma (pRb) protein. The methylation of the p16 gene has been reported in canine lymphomas, however, p16 protein expression has not been examined in previous studies. In this study, the gene and protein expression of p16, and phosphorylation of pRb, were examined simultaneously in canine lymphoma/leukemia cell lines treated with or without a demethylation drug in vitro. We identified the hypermethylation of the p16 gene, the decreased expression of p16 protein and the hyperphosphorylation of pRb in four out of eight cell lines. Furthermore, we revealed that the expression of the p16 protein was more stable than that of the p16 gene and more closely related to the phosphorylation of pRb. In conclusion, the p16 protein expression is suggested as a promising biomarker for canine lymphoma cells, and the p16–pRb pathway could be a target for the better treatment of canine lymphomas. Abstract Cyclin-dependent kinase inhibitor p16 (CDKN2A) primarily functions as a negative regulator of the retinoblastoma protein (pRb) pathway to prevent pRb phosphorylation, thus playing a critical role in cell cycle arrest. In canine lymphoma cells, methylation due to inactivation of the p16 gene has been reported. However, its protein expression has not been examined in previous studies. In our in vitro study, the gene and protein expression of p16 and phosphorylated pRb were examined simultaneously in eight canine lymphoma and leukemia cell lines (17-71, CLBL-1, GL-1, CLC, CLGL-90, Ema, Nody-1, and UL-1). Methylation of the p16 gene was also explored using the demethylation drug 5-Aza-2′-deoxycytidine (5-Aza). After 5-Aza treatment, p16 gene and protein expression increased and pRb phosphorylation decreased, suggesting that both hypermethylation of the p16 gene and pRb hyperphosphorylation occurred in four out of eight cell lines (CLBL-1, CLC, Nody-1, and UL-1). Moreover, the estimation of p16's protein expression was better than that of p16's mRNA expression because the expression of the protein was more stable than those of the gene, and highly related to the phosphorylation of pRb. These results revealed that p16's protein expression could be a promising biomarker for canine lymphoma cells.


A new geometrical setting for classical field theories is introduced. This description is strongly inspired in the one due to Skinner and Rusk for singular lagrangians systems. For a singular field theory a constraint algorithm is developed that gives a final constraint sub-manifold where a well-defined dynamics exists. The main advantage of this algorithm is that the second order condition is automatically included. 1. Introduction. The search of a convenient setting for classical field theories has been an strong motivation for geometers and physicists in the last forty years. In the end of the sixties it was developed the so-called multisymplectic formalism, which is a natural extension of the symplectic framework for mechanics.


Multiple air conditioning system and method for detecting which pipe is connected, wherein the plurality of indoor units according to an operation mode of the packet, so that the connection tube is quickly and correctly detected. The method comprises grouping a plurality of indoor units according to an operation mode; and simultaneously operating a plurality of indoor units each indoor unit to detect which is connected to the corresponding refrigerant tube, the multi-air conditioning system including an outdoor unit connected to the outdoor unit and a plurality of indoor units are connected to the refrigerant pipes of the indoor unit and independently connected to the outdoor unit.


The paper explores the main processes and determinants of growth of SMEs in Croatia and empirically explores the data generated through SME Exporters Survey covering the period between 1999 and 2004. The paper is based on a micro level analysis focusing on the characteristics of particular SMEs and entrepreneurs/managers that have achieved strong growth in terms of revenues, the number of employees and exports. When analysing SMEs' growth, existing research often tends to emphasise the factors such as innovativeness and exportorientation, which is partly confirmed by findings presented in the paper. However, institutional change and economic restructuring imply differences in successful business strategies and factors that are conducive to SME growth in Croatia as opposed to more developed economies. Consequently, application of growth-oriented strategy is often inconsistent and/or based on taking advantage of market imperfections.


Thank you for downloading high desert and canyon country. As you may know, people have look hundreds times for their chosen readings like this high desert and canyon country, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they juggled with some harmful bugs inside their laptop. high desert and canyon country is available in our book collection an online access to it is set as public so you can download it instantly. Our books collection saves in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the high desert and canyon country is universally compatible with any devices to read.


The Department of Egyptian Art in the Museum of Fine Arts, Boston, has long benefited from the friendship and munificence of Mr. Horace L. Mayer who has deposited many objects from his collection either as gifts or loans in the Museum. Several important pieces of ancient Egyptian jewelry and glass from Mr. Mayer's collection are now on loan to the Museum and, as is often the case with small objects from the ancient world, not many conclusions can be reached about the original nature of certain of these pieces. Nevertheless, we hope a purpose will be served by making them known to a wider public. Three glass objects are included in the treasure and we consider them together because there is little doubt about their date and the similarity of their ancient use. The face of a man in dark blue


Public art education has become an important education content of current college quality-oriented education in China. It could improve college students' overall qualities and harmonious development, and thus college students could form socialist core values. Based on this, this paper discusses about public art education, and elaborates the positive role of public art education in the formation of Chinese college students' socialist core values. With the changes of international situation and China's reform and opening up, the rapid development of socialist market economy has brought evident achievements for China's socialist modernization, but we shall also see both opportunities and challenges. Only by adhering to socialist core values, can we better master the direction of construction. Socialist core values are the kernel of socialist core value system, reflect the fundamental nature, basic characteristics, rich connotation and practical requirements of this system, and are exquisite compression and concentrated expression of this system. Thus, establishment of socialist core values is the highlight of the Communist Party of China in terms of ideological and cultural construction in this new century, and also provides a new perspective for ideological and political education for contemporary college students. I. Position and role of public art education in promoting the formation of values


The objective of this study was to determine the efficacy of supercritical carbon dioxide turmeric extract (STE) on the oxidative stability of perilla oil (PO), as measured by acid value (AV), peroxide value (PV) and oxidation induction time and compared to control and α‐tocopherol containing PO as a positive control. The antioxidant activity was determined by DPPH, ABTS and FRAPS assays and individual bioactive compounds identified by chromatography. STE demonstrated significantly higher antioxidant activity than the α‐tocopherol. The major components of the STE were identified as ar‐turmerone, turmerone, curlone and bisabolene by GC‐MS and curcumin and demethoxycurcumin by UPLC‐Q‐TOF MS. During thermal treatment at 65 °C for 24 h, the PO containing STE at different concentrations (100, 300, 500 and 1000 μg mL⁻¹) had significantly lower AV and PV, and at least 1.5 times higher induction period than those of the control and α‐tocopherol‐incorporated PO.


In this work, the tracking problem for permanent magnetic synchronous linear motor systems is studied. We develop a novel barrier Lyapunov function-based adaptive control scheme for linear motor systems with system constraints. The filtering-error is constrained by using a new type of BLF so as to simplify design, which is different from the existing results. The time-varying boundary layer technique is introduced to reduce the difficulty of choosing the barrier parameter. Also, a neural network is adopted for dealing with nonparametric uncertainties. In the end, a simulation example is presented to demonstrate the effectiveness of our barrier adaptive control algorithm against traditional barrier-free adaptive control algorithm.


Ta2O5-based MOS capacitor was fabricated on p-type(100) Si substrates using a dual ion beam sputtering method(DIBSD),In this letter,influence of various assisted source energy(0,100,200,300eV,respectively) on the film's growth mechanism,internal microstructure and electrical properties of Ta2O5-based capacitor had been studied.The experimental result showed that the Ta2O5 film prepared under 200eV had the smallest surface roughness and excellent interfacial characteristics.C-V and I-V characteristic curves indicated that the Ta2O5 MOS had the minimum value of flat voltage offset,density of oxides charges and leakage current.Eventually we found the appropriate assisted source energy can effectively improve the film's growth mechanism and makes the film growth type from the island into a layered,which would improve the uniformity of crystalline grain and the film's roughness and compactness.


Every day media reports acts of violence in various kinds. Crime statistics shows that threats and violence are increasing in regard to both frequency and intensity within the nation. Nurses in t ...


Relative nonrenewable resource depletion potential(RNRRDP)as a new evaluating indicator to the renewable capability of fuels was put forward in this paper,which could provide significant evidence for the evaluation of the fuel life cycle renewable capability.Besides,the case study was also introduced by analysis of the life cycle renewable capability of cassava-based ethanol and gasoline.And it was concluded that the renewable capability of cassava-based ethanol was better than that of gasoline.The indicator could also be used in the evaluation of other fuels and it was of high use value.(Tran.by YUE Yang)


Open the laboratory system with a view of the reality that school manages ,the campus having designed that one takes campus net as basis ,takes fingerprint identification instrument as carrier ,takes fingerprint identification technology as dignity attestation means. The rationale the main body of a book has been introduced detailedly should be system ,key technology and the merit having implemented the scheme,and analyzing to change system.


The optimum bean for Ganoderma lucidium solid-state fermentation was investigated in this paper,with the 11 various beans(soybean,purple kidney bean,haricot,white pea,lima bean,black bean,green pea,mung bean,variegated kidney bean,red kidney bean and white kidney bean) as the nature medium.The Ganoderm Lucidum solid-state fermentation conditions including the thickness of medium,inoculum,cultivation time and fermentation temperature were further examined,respectively.As a result,when Ganoderma Lucidium mycelium was cultured with soybean as the solid medium,the maximal concentration(1 695.5 μg/g) of free amino acids was obtained,and the optimal conditions for Ganoderma Lucidium degrading soybean were following:50 g per250 mL fermentation medium,10% inoculum,cultivation temperature 30℃,6 days of fermentation time.


This chapter presents an empirical analysis of various factors influencing the risk perceptions and overall assessment and satisfaction level on the performance of the outsourced activities of the banks. The analysis highlights the degree of various factors that influence the risks, comparative perception of importance vs. actual performance and satisfaction levels of the respondents, who are bank executives.


As computing systems become an ever more integral aspect of our everyday lives, the demand for more domain appropriate forms of interface technology has increased substantially. Nowhere is this better seen than small hand-held devices, which currently utilize awkward techniques such as specialized scripts or on-screen keyboards. Achieving the goal of ubiquitous computing will require a departure from standard methods, leading to renewed interest in natural I/O technologies such as speech recognition. Unfortunately, the computational demands of robust, large vocabulary speech recognition are well beyond the capabilities likely to be seen on handheld systems in the near future.
This work explores the potential for utilizing domain specific characteristics of natural I/O workloads to achieve the necessary functionality within the energy constraints of low power systems. We focus on speech recognition, and exploit the massive amounts of easily exposed thread level concurrency (1000s to 10,000s of potential threads) inherent in this application. We present a hybrid multi-threaded, chip-multiprocessor architecture utilizing small, unsophisticated processing elements and numerous latency tolerating mechanisms to maximize processor utilization and system throughput. Under idealized memory constraints, such a system achieves near linear speedup with added parallel resources, often correlating to a reduction in workload energy consumption despite the added power dissipation.
We next turn our attention to the memory system, determining that memory bandwidth is the key constraint in this domain. Streaming access to knowledge base data can severely constrain achievable performance. We find that a multi-level caching strategy, targeting L2 sizes to match higher locality program metadata (<256K) can achieve significant improvements in performance by reducing bandwidth demand. Overall, we find that a fairly small CMP/MT architecture (4 processors, 2–4 hardware thread contexts each) with such a multi-level memory system can achieve or exceed realtime performance on moderate complexity tasks, and that the inherent properties of our architecture make techniques such as dynamic concurrency management, data compression in the lower levels of the memory system, and voltage and frequency scaling quite effective at providing realtime speech recognition within the energy budget of low-power portable systems.


Errors were unfortunately introduced into this paper. On page 6737 equation (1) should read: On page 6741 the line before equation (IA) and equation (IA) should read: ... limiting cases (i.e. ignoring the contribution from exchange) by Buckingham in the form


e15554 Background: Stage III colorectal cancer (CRC) is defined as patients with regional positive lymph nodes (pLN) but without distant metastasis, including stage IIIA, IIIB, IIIC. The prognosis of patients with stage III CRC varies dramatically, with 5-year survival rates ranging from 80 percent to 30 percent form stage IIIA to IIIC CRC, that does not exactly to be fully explained by the difference in the number of pLN. Therefore, other prognostic indicators need to be identified to improve and personalize prognosis prediction for patients with stage III CRC. Intratumor heterogeneity (ITH) widely exists between primary and metastatic lesions of CRC, however, there have been few studies focused on ITH of pLN. Therefore, this study aims to explore whether ITH of pLN could serve as a novel prognostic stratification factor for stage III CRC. Methods: We retrospectively analyzed the Poly-G genotype to reconstruct high-confidence phylogenetic trees for 20 CRC patients using 317 accurately scraped biopsy (134 primary tumors, 66 lymph node metastases and 37 normal samples). Root diversity score (RDS) index was used to reflect ITH of pLN. The association among Poly-G mutation rates, RDS index and clinical pathological data was analyzed. The area under the receiver operating characteristic (ROC) curves were calculated and the cut-off valve was confirmed. Results: Poly-G mutations accumulate in the occurrence and development of CRC. Poly-G mutation rate was correlated with tumor grade, N stage and microsatellite state (all P < 0.05), and had a certain correlation trend with age (P = 0.066). The results of multivariate Cox regression analysis showed that ITH of pLN was an independent risk factor for recurrence and metastasis which lead to a poor progression free survival (PFS). The area under the curve (AUC) was 76%, and the cut-off valve of RDS index was 0.25. We also found ITH of pLN was not associated with substages of stage III CRC, which indicated that ITH of pLN and the number of metastases are two different dimensions. Conclusions: ITH of pLN may provide a promising prognostic stratification factor for the patients with stage III CRC. A higher ITH of pLN indicates that subclones with distant metastasis potential might more likely to exist in the primary tumors, which lead to a poor PFS including recurrence and distant metastasis. In addition, ITH of pLN is not related to the number of lymph node metastases in stage III CRC, suggesting that ITH of pLN is promising to serve as a supplementary strategy of TNM staging for patients with Stage III CRC.


Helicos™ Single Molecule Sequencing (SMS) provides a unique view of genome biology through direct sequencing of cellular nucleic acids in an unbiased manner, providing both accurate quantitation and sequence information. Sample preparation does not require ligation or PCR amplification, avoiding the GC‐content and size biases observed in other technologies. DNA is simply sheared, tailed with poly(A), and hybridized to a flow cell surface containing oligo(dT) for sequencing‐by‐synthesis of billions of molecules in parallel. This process also requires far less material than other technologies. Gene expression measurements can be done using first‐strand cDNA‐based methods (RNA‐Seq) or using a novel approach that allows direct hybridization and sequencing of cellular RNA for the most direct quantitation possible. In this unit, principles and methods for using the Helicos® Genetic Analysis System are discussed. Curr. Protoc. Mol. Biol. 92:7.10.1‐7.10.14. © 2010 by John Wiley & Sons, Inc.


A manufacturing process quality model for investigating the operation of a manufacturing unit has been developed incorporating the failure mechanism of instantaneous assignable cause, mean drift and standard deviation drift. Describes an illustrative example, showing how the new model can be used in conjunction with simulation to optimize the control of a manufacturing process from a cost‐quality perspective.


The utility model relates to a windshield wiper head capable of being bent and expanded, which belongs to the field of automobile parts. The windshield wiper head is composed of a rubbery blade, an elastic metal strip, a clip in large size, a clip in intermediate size and a clip in compact size. A concave shaped installation slot and a concave shaped sliding slot are symmetrically produced on the upper portion of the rubbery blade, having a concave shaped clamping slot produced on one end. Elastic metal strips are assembled in the concave shaped installation slot, the clip with compact size is mounted on the upper end of the rubbery blade through a concave shaped sliding slot and intervals between concave shaped clip slots, and stacking hinged clip in large size and clip in intermediate size are movably riveted on the clip in compact size. During the working of the windshield head, under the action of the pressure of the swinging rod, the rubbery scraping blade can be freely bent or expanded within the fastener of the clip in compact size along a concave shaped sliding slot on the vehicular glass with a curtain curvature so as to achieve the object of fully adhesion between the rubbery scraping blade and the vehicular window glass. Therefore the problem of the windshield wiper in the prior art that the rain and the dust can not be wiped completely due to incapability of being bent and expanded and fully adhered to the vehicular window, and thus the appearance and vision field is affected is solved. The windshield wiper head is simple in structure, low in production cost, and is suitable for various kinds of vehicles.


For meaning representations in NLP, we focus our attention on thematic aspects and conceptual vectors. The learning strategy of conceptual vectors relies on a morphosyntaxic analysis of human usage dictionary definitions linked to vector propagation. This analysis currently doesn't take into account negation phenomena. This work aims at studying the antonymy aspects of negation, in the larger goal of its integration into the thematic analysis. We present a model based on the idea of symmetry compatible with conceptual vectors. Then, we define antonymy functions which allows the construction of an antonymous vector and the enumeration of its potentially antinomic lexical items. Finally, we introduce a measure which evaluates how a given word is an acceptable antonym for a term.


Abstract Combustion of hazardous and municipal waste produces a wide variety of emissions which need to be considered when assessing potential human health risks. A major focus in recent years has been excess cancer risks. The main emissions which rodent studies indicate may be carcinogenic to humans include organic chemicals such as dioxins, furans and polychlorinated biphenyls, which are highly persistent in the environment. Certain metals known to be carcinogenic to humans, such as arsenic, cadmium, chromium and nickel, are also emitted. Priorities for consideration among non-carcinogenic emissions include lead and mercury. Methods for health risk assessment of air emissions are presented in this paper, and illustrated with data from a risk assessment of emissions from a municipal waste incinerator. The most significant potential exposure pathways were fish, meat, and milk consumption, which are dependent on the siting of facilities in relation to fishable lakes and land used for animal grazing or food...


The invention discloses a pickled pepper and mushroom sauce and a preparation method thereof, relating to a pickled pepper and mushroom sauce prepared from edible fungi (mushrooms) and pickled peppersand a preparation method thereof. The prescription comprises the following raw materials: 10-50 percent of soybean oil, 20-50 percent of fermented mushrooms, 2-40 percent of pickled peppers, 2-20 percent of celery, 2-20 percent of carrots, 1-10 percent of onions, 1-10 percent of garlic, 2-5 percent of sugar, 1-2 percent of monosodium glutamate and 0.5-2 percent of spice. The preparation method has the steps as follows: preprocessing the raw materials, frying sauce, packing and sterilizing. The pickled pepper and mushroom sauce has unique flavor, sweet and peppery palatability and full delicious taste, stimulates the appetite to increase the appetite of food, is rich of various easily absorbed nutrient components and is a delicious, nutrient, convenient and healthy green food.


Context. Detailed studies of intermediateand low-mass pre-main-sequence (PMS) stars outside the Galaxy have so far been conducted only for small targeted regions harbouring known star formation complexes. The VISTA Survey of the Magellanic Clouds (VMC) provides an opportunity to study PMS populations down to solar masses on a galaxy-wide scale. Aims. Our goal is to use near-infrared data from the VMC survey to identify and characterise PMS populations down to ∼1 M across the Magellanic Clouds. We present our colour−magnitude diagram method, and apply it to a ∼1.5 deg2 pilot field located in the Large Magellanic Cloud. Methods. The pilot field is divided into equal-size grid elements. We compare the stellar population in every element with the population in nearby control fields by creating Ks/(Y−Ks) Hess diagrams; the observed density excesses over the local field population are used to classify the stellar populations. Results. Our analysis recovers all known star formation complexes in this pilot field (N 44, N 51, N 148, and N 138) and for the first time reveals their true spatial extent. In total, around 2260 PMS candidates with ages .10 Myr are found in the pilot field. PMS structures, identified as areas with a significant density excess of PMS candidates, display a power-law distribution of the number of members with a slope of −0.86 ± 0.12. We find a clustering of the young stellar populations along ridges and filaments where dust emission in the far-infrared (FIR) (70 μm–500 μm) is bright. Regions with young populations lacking massive stars show a lower degree of clustering and are usually located in the outskirts of the star formation complexes. At short FIR wavelengths (70 μm, 100 μm) we report a strong dust emission increase in regions hosting young massive stars, which is less pronounced in regions populated only by less massive (.4 M ) PMS stars.


This paper put forward the significance of visual center in silk women clothes design,especially analyzed the principle of management of visual center to place and quantity of visual center in silk women clothes design,explored the treatment efficiency of visual center,concluded the relationships between the whole and the part and the relationships between the part and the part in silk women clothes design.


Aanalyzes the running mechanism of Oracle JDBC connection cache, and give a concrete usage about how to optimize the database performance in JSP by this technology.


A video sequence is usually composed of multiple shots, which are the basic units for higher-level content analysis, indexing, editing and so forth. As such, shot boundary detection is usually the first step toward content-based video applications. Correspondingly, many researchers have worked in this field and proposed many good algorithms. However, there is still much room for improvement in gradual transition detection capability and computational efficiency with those algorithms. The proposed method improves upon the graph cut algorithm based on mutual information for better detection accuracy and efficiency. In addition, we employ hierarchical analysis both spatially and temporarily on the video data, leading to reduced computation and improved gradual transition detection accuracy. Experiments on the public test video data demonstrate that the proposed algorithm improves both the efficiency and the accuracy of shot boundary detection, when compared with related works.


Background Cognitive appraisal constitutes an important mechanism in the process of human adaptation to work environment and occupational stress. In this domain, nursing professionals are one of the occupational groups most affected by job stress, suffering high levels of psychological distress. Objectives The aims of this study were to analyze the moderator effect of shift work and the type of job contract on the relationship between work cognitive appraisal and nurses' psychological distress and to explore the interaction effect of the two moderator variables on that relationship. Methods A sample comprised of 2,310 Portuguese registered nurses completed a sociodemographic and professional questionnaire: the Primary and Secondary Cognitive Appraisal Scale and the General Health Questionnaire-12. Data were analyzed through structural equation modeling and multigroup analyses considering the following groups: (a) "shift" versus "nonshift work"; (b) "precarious job contract" versus "nonprecarious job contract"; and (c) "shift and precarious" versus "shift and nonprecarious" versus "nonshift and precarious" versus "nonshift and nonprecarious." Results Data confirmed the invariance for the measurement model, but the structural model presented a significantly worse adjustment for all grouping variables, showing the moderator effect of shift work and job contract and of their interaction. Difference tests in structural path coefficients revealed that shift work moderated the relationship between challenge perception and psychological distress—which was stronger for shift work nurses—and that a higher threat perception was related to greater psychological distress, especially in nurses with a precarious job contract. Among the four categories of interaction between job contract and shift work, cognitive appraisal became central in predicting nurses' mental health, explaining more variance in the group that did shift work and had a nonprecarious job contract. Discussion The study results highlight the need to develop occupational health intervention programs to promote nurses' mental health, focusing on reducing work perception as a threat and on making nurses' jobs more challenging and controllable.


In the present paper is shown how to obtain an objective explicit algebraic extra-stress model (AESM) based on differential constitutive equations for viscoelastic flows (Oldroyd B, White-Metzner, Phan-Thien-Tanner, etc). The formulation is developed for three-dimensional time-dependent flows. In a previous work, Mompean, 1998 obtained a non-objective algebraic model. This inconsistency is now removed introducing the relative-rate-ofrotation tensor making the model frame-invariant. A new generalized objective time derivative is also introduced, giving flexibility to the model. Calculations are performed with an Oldroyd B based AESM for a 4:1 contraction flow, showing good agreement with the original constitutive differential model. Several results with particular derivatives are obtained and an analysis guided by a flow type classifier is given. This formulation is able to include a prediction, not present in the Oldroyd B model, the viscometric second normal stress difference, N2.


Purpose. To present clinical cases of macular edema associated with central retinal vein thrombosis (CRVT) of various etiologies. Material and methods. A prospective study of patients with macular edema associated with thrombosis of the central retinal vein or its branches in real clinical practice was conducted. All patients underwent a standard ophthalmological examination, as well as optical coherence tomography (OCT), and a biochemical blood test was performed on a patient with suspected macroglobulinemia. Results. In the first clinical case, macular edema was associated with retinovasculitis. The patient was consulted by a rheumatologist, diagnosed with idiopathic dermatomyositis, polymyositis, confirmed seropositive form. A long-term regimen of glucocorticosteroid drugs (Prednisone), courses of lymphosorption was prescribed. Treatment was carried out for macular edema, occlusion of the central nervous system on the background of retinovasculitis: anti-VEGF therapy, retinal laser coagulation. In the second clinical case, macular edema on the background of CRV thrombosis associated with Waldenstrom's disease. It is recommended to monitor and treat the underlying disease with a hematologist. Conclusion. Thus, macular edema occurring against the background of thrombosis of the central nervous system and its branches, having atypical symptoms in the form of exudative retinal detachment, the presence of a bilateral process, young age and the absence of risk factors for the development of retinal vein occlusion, as well as resistance to anti-VEGF therapy requires careful collection of anamnesis taking into account the patient's somatic condition and the presence of other ophthalmological vascular pathology. Keywords: macular edema, retinovasculitis, Waldenstrom macroglobulinemia


Although Cerebral Palsy (CP) is a lifelong disability, the research has mainly focused in children with CP. However, in recent years new studies have examined the different aspects of being an adul ...


Medical planning requires information on the extent and distribution of health problems; often this is not available, especially locally. A geriatrician asks about the extent of unmet need among district residents. An inner-city psychiatrist wants to back his request for more facilities by some evidence of high local morbidity. A physician needs to know how much hypertension would be uncovered if blood pressures were measured in non-medical clinics. A general practitioner wonders if there really is a local excess of bronchitis. A chemical pathologist wishes to establish a "range of normal." In some such ways almost any doctor may find himself needing to undertake a simple cross-sectional survey. We will attempt to help him in our articles this week and next.


According to the crust defects in machining cylinder block,the reasons for the defects were analyzed.The improved casting technique was obtained by adopting a series of measures.As a result,the crust defect was eliminated and the machining quality of part was improved.


Torrefaction experiments were carried out on some Nigerian woody (Albizia pedicellaris (AP), Tectona grandis (TK), Terminalia ivorensis (TI)) and non-woody (Sorghum bicolour glume (SBG) and stalk (SBS)) biomass resources. The influence of process conditions and consequent change in the elemental configuration of the biomass samples were observed. Biomass type played a dominant role in the solid yield recording 71% for woody and 58% for non-woody samples at 270 ◦C, while temperature showed the greatest influence with solid yield dropping from an average of 80% (at 240 ◦C) to 50% (at 300 ◦C). Both volatile matter and fixed carbon contents experienced significant changes after torrefaction and a decline in O/C ratio from 0.6 to 0.3 was noted. Among the woody biomass, TI experienced the highest increase in higher heating value (HHV) of approximately 38% as compared to AP (32%) and TK (32%), and was subsequently selected for decomposition kinetic study. The decomposition kinetics showed that activation energy −1 (E( ̨)) for the hemicellulose degradation stage ranged between 137 and 197 kJ mol for conversion ( ̨) between 0.1 and 0.24 implying that biomass kinetics within this decomposition region is a multi-step reaction. The GC/MS analytical technique revealed that the presence of levoglucosan was highest (7.1%) in woody biomass, while phenolic compounds made up more than one-third of the group of compounds identified. © 2014 Elsevier B.V. All rights reserved.


This study was performed to investigate the effects of prolonged immersion vaccination in a dilute vaccine on the farmed olive flounder, Pararlichthys olivaceus. Juvenile olive flounders were immersed in the several diluted (, , and ) commercial edwardsiellosis bacterins (5㎎/l) for 2min (short immersion, SI) and 24 h (prolonged immersion, PI). After immunization, fish were analyzed to investigate on non-specific (serum lysozyme and bactericidal activity), specific immune responses (antibody agglutinin titer) and resistances against Edwardsiella tarda infection. The PI of the commercial vaccine diluted with and showed better results over the untreated control in terms of serum lysozyme, bactericidal activities and resistance against E. tarda infection. These results suggest that the prolonged treatments of the diluted vaccine might be a new approach improving the vaccination potential


Conventionally, raised floor data centers operate using controllers that only maintain constant data center space conditions (i.e. supply air temperatures or return air temperatures) at the Computer Room Air Conditioning (CRAC) Unit level with the intention of providing enough cooling for the servers. The objective of this paper is to explore the framework required to design a controller that regulates server CPU temperatures by specifying the supply air temperature of the CRAC. The controller will be an addition to the existing controller used by the CRAC to regulate supply air temperatures. In the discrete-time domain, implementation and the performance of the modified integral action controller is analyzed and other important parameters are compared. As a preliminary attempt, the controller will be designed for a standard 44U cabinet with 42 "1U" servers, where the machines will execute a prescribed compute load variation: (1) step increase in all compute loads and (2) scaled down representation for a rack of servers using utilization trends from one of Google's data centers. Ultimately, the development of this controller is motivated by the growing interest in Data Center Infrastructure Management (DCIM) where the IT level and facility level information are both used to intelligently plan and manage resources of a data center.Copyright © 2012 by ASME


Aiming at the problems of introducing passenger dedicated line into railway terminal,the essay analyzes the influencing factors on site selection of station,devises the structural model of evaluation index and index system,and explains the evaluation process by combining with AHP method.In the end,the essay makes an evaluation on the plan of site selection of station for introducing Beijing-Guangzhou passenger dedicated line into Hengyang railway terminal.


In recent years, topological insulators have drawn growing interest as a unique electronic state of matter toward quantum information technology. Despite the logic devices with magnetization switching through spin–orbit torque or the topological magneto-electric effect, realizing memory devices based on topological insulators has been urged in quantum computing applications. In this work, we report the design and fabrication of a non-volatile memory device that employs polarization of Bi2Se3 thin films achieving fast memory speed, sufficient memory window, and good reliability. The Bi2Se3 film polarizes under an external electrical field with charges accumulated on the top and bottom surfaces separating the electrons and holes. Such polarization is much faster than the carrier tunneling in conventional floating-gate flash memory and ferroelectric-based memory devices. In addition, good memory retention and endurance properties have also been obtained, showing great potential in high-performance memory application in future topological insulator-involved information technology.


FIELD: steel making. SUBSTANCE: converter for making steel of solid and/or liquid initial substances, such as cast iron ingots and/or scrap and/or sponge iron, includes a tank for remelting with refractory layer, remelting device using oxygen or oxygen-carrying gas, and heating device. At least one self-consuming graphite electrode is used in the heating device to obtain maximum productivity with large amount of charged scrap, and steel of high purity. Remelting device is independent of heating device or has oxygen lance, or includes bottom blast lances and/or lateral blast lances placed below melting bath level. EFFECT: steel of high quality. 1 dwg


In order to accomplish the environmental friendly power system and improve the noise treatment level of power transmission and transformation project, the audible noise of 9 seat substations and 13 bands transmission lines in different voltage levels are field measured and analyzed combine with the actual situation of south power system for a province. So the frequency and attenuation characteristics of the audible noise are researched based on the testing data considering the transformer, reactor, charged architecture, substation boundary and transmission lines. The testing results show that the main noise source of transmission and transformation project is the transformer, reactor and transmission lines, which the main frequency of noise is low frequency noise in substation. It can provide a basis for the substation and noise control zone design.


We study how low-density (background = BG) electrons affect the generation processes of ordered structures in the distribution of high-density electrons (clumps) in two-dimensional dynamics transverse to a homogeneous magnetic field. Here, by reviewing recently-published work [1,2], we discuss mainly on two experimental results: (1) twoclump dynamics focusing on bifurcation between merger and close-separation under critical contribution of BG electrons, and (2) their contribution to advecting three clumps to a symmetric configuration and sustaining the geometry of an equilateral triangle that represents a unit cell of vortex crystals. We regard the two phenomena are among key processes supporting the self-organization of ordered structures in many-particle systems with long-range interacting force.


Results about existence and uniqueness of solutions of initial value problem for certain types of partial differential equations are recalled as well as iterative scheme and an error estimate for approximate solutions obtained using this scheme. Several numerical examples are presented to demonstrate how the proposed iterative scheme can be applied, with emphasis given to verifying assumptions of using the scheme. Comparison to other recently presented results is done in this respect.


In this work, rising of a single bubble in a quiescent liquid under microgravity condition was simulated. The related unsteady incompressible full Navier-Stokes equations were solved using a conventional finite difference method with a structured staggered grid. The interface was tracked explicitly by connected marker points via hybrid front capturing and tracking method. One field approximation was used, while one set of governing equations was only solved in the entire domain and different phases treated as one fluid with variable physical properties. The interfacial effects are accounted for by adding appropriate source terms to the governing equations. The results show that the bubble moves in a straight path under microgravity condition, compared to the zigzag motion of bubbles in the presence of gravity. Also, in the absence of gravity and temperature gradients, the hydrodynamic effect can still cause the upward motion of the bubble. This phenomenon was explicitly shown in our results.


Linear one step methods of a novel design are given for the numerical solution of stiff systems of ordinary differential equations. These methods permit fast integration with increments h of the independent variable adjusted to the slowly varying, dominant solutions. The integration formulas owe their efficiency to combining a reasonable order of accuracy for $h \to 0$ with a precise simulation of specific rapidly varying solutions, and with A-stability in the sense of Dahlquist.


1. We tested whether increasing atmospheric nitrogen (N) deposition along a north-south gradient intensifies epilithic phosphorus (P) limitation in oligotrophic Swedish lakes from the north to the ...


Psychological researchers, while studying internal reference price, have dealt with different types of psychological effects like attraction effect and compromise effect. While studying consumer reference price and willingness to pay, marketing researchers have focused on consumers' perception about a brand by evaluating several attributes of that brand. Our research investigates the incremental effect on consumers' willingness to pay in a context where an adjacent price is present, for instance, when a medium priced brand is associated with a high price brand than a moderately high priced brand. Unlike other pricing research, this research deals with consumer's individual level heterogeneity as price sensitivity and consumers' willingness to pay for a particular brand since they vary among individual. Hierarchical Bayes methodology is used to incorporate such heterogeneity. The study shows significant difference in consumers' utility and her willingness to pay when a medium priced brand is compared with a high priced brand as against a moderately high priced brand.


The compartment (1) is fitted as part of the inner trim (4) on the A-pillar (2) in the foot space (3) associated with the driver or passenger side. The lid (5) is designed to swivel about an at least approximately vertically aligned swivel axis. The opening of the compartment can be on the side facing the adjoining vehicle door. The compartment can extend over the entire width of the inner trim and has a detent mechanism for closing the lid.


In a battery of four acute and chronic nociceptive tests, the GABA antagonist picrotoxin produces a uniform and sustained analgesia in mice. By contrast, barbiturates which have been presumed to act at the same receptor produce mixed and paradoxical actions. At a standard time of 10 min after drug administration a convulsant barbiturate [5‐ethyl‐5‐(3′‐rnethyI‐but‐2′‐enyl)‐barbituric acid] produced analgesia in three tests but had no effect in the fourth; a pure hypnotic barbiturate (amylobarbitone) produced hyperalgesia in three tests but analgesia in the fourth; while the mixed hypnotic‐convulsant pentobarbitone produced hyperalgesia in two of the tests and was without any effect in the other two. There was no pattern in these results with respect to acute or chronic nociceptive tests. Surprisingly, with extended observation using the tail‐flick test both pentobarbitone and the pure hypnotic (amylobarbitone) gave early hyperalgesia followed by analgesia; the convulsant barbiturate gave only analgesia. The results suggest a role for GABAA receptors in the transmission of nociceptive information; they also suggest that barbiturates act at quite a different receptor.


ABSTRACT In this work, a borate calcium additive was added to lithium and polyurea greases to investigate the tribological performance. Friction and wear tests were conducted on a four-ball machine under higher load and a reciprocating tribometer under lower load. X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) analyses were performed on the worn surface after the tests. It was found that the tribological performance affected the boundary layers formed by the additive and the soap fibers. The boundary films in lithium grease mainly consist of ferrum hydroxide, and more oxide can be found in polyurea-based films. SEM analyses of soap fibers show that the soap fibers in polyurea-based grease were more separated than those in lithium-based grease. Compared to the base grease, the soap shows smaller and shorter fibers.


Objective To investigate the effects and possible mechanisms of decitabine on heat-shock protein 22 (HSP22) expression in hematopoietic tumor cell lines and bone marrow samples from patients with hematopoietic tumor.Methods The expression of HSP22 in 13 hematopoietic tumor cell lines,20 primary patients' samples and 10 normal donor' samples were detected by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR).After HSP22 induction with a demethylating agent decitabine (2 μmol/L),the methylation of the HSP22 promoters in hematopoietic tumor cell lines,healthy donors and bone marrow samples from patients with hematopoietic tumor were detected by methylation specific PCR (MSP).Results Expression of HSP22 was not detected in 13 hematopoietic tumor cell lines,20 primary patients' samples or 10 healthy donors' samples.Decitabine can induce the expression of HSP22 in hematopoietic tumor cell lines and bone marrow samples from patients with hematopoietic tumor.Decitabine can maintain partially demethylation of HSP22 promoters in hematopoietic tumor cell lines.HSP22 promoters were highly methylated in BMMC of the healthy donors and patients with hcmatopoictic tumor.Conclusion Decitabine can induce the expression of HSP22 in hematopoietic tumor cells partly by demethylation of HSP22 promoters.

Key words:
Hematologic neoplasms;  Decitabine;  Heat-shock protein 22


A novel concise method to synthesize rigid analogues of flavone by an intramolecular Heck reaction with wide substrate scope was developed. The key intermediates 3-(2-bromobenzyl)-4H-chromen-4-ones were prepared easily in two steps. Most compounds were obtained with moderate to good yields (34–90 % yield, 19 examples).


This paper presents a novel method for the design of passive components for battery powered SEPIC dc-dc switching regulators. The method is based on use of Acceptability Boundary Regions (ABR), which determine an area, in the space of parameters, corresponding to commercial components which ensure acceptable voltage ripples, fulfillment of maximum allowed power dissipation, and non pulsating source current absorption. The effectiveness of this technique is strengthened by a practical method to assign a loss budget distribution among passive components. It is shown that the new approach allows to figure out most convenient design solutions without making preliminary assumptions of inductors current ripples, but rather considering them like an optimization parameter.