Abstract 34 We performed randomized phase III study to compare the regimen related toxicities (RRT) of two different conditioning regimens, cyclophosphamide (CyATG) vs. cyclophosphamide plus fludarabine (CyFluATG) given in addition to anti-thymocyte globulin (ATG) for allogeneic hematopoietic cell transplantation (alloHSCT) for bone marrow failure syndrome including severe aplastic anemia (AA) and hypoplastic myelodysplastic syndrome (MDS). CyATG consisted of Cyclophosphamide (Cy) 50 mg/kg (D –5 to –2). CyFluATG arm received fludarabine (Flu) 30 mg/m2 (D –6 to –2) and Cy 50 mg/kg (D –3 to –2). Thymoglobuline 3 mg/kg, lymphoglobulin 15 mg/kg on days -4 to -2 or alemtuzumab 20mg on day -4 were infused in both arms. Patients were stratified by stem cell donor (related vs. unrelated). Total 83 patients (40 patients to Cy-ATG and 43 patients to Cy-Flu-ATG) were enrolled from February 2003. All patients except for one patient, who had assigned to Cy-Flu-ATG arm and died during conditioning, received full planed regimen and all planned patients were included in this analysis. Median age was 34 (15-60) years and male patients were 42/83 (50.6%). AA patients were 79 and MDS were 4. Matched sibling donors were 53 (63.9%). ATG was used in form of thymoglobulin (n=75, 90.4%), and some patients had received ALG (n=5, 6.0%) or alemtuzumab (n=3, 3.6%). Median duration from diagnosis to transplantation was 4.7 (0.2-177.7) months. Age, gender, donor type were not different in both arms (Table 1). Various TRT were similar between Cy-ATG and Cy-Flu-ATG (Table 2); granulocyte graft failure rate (p=0.959), platelet graft failure rate (p=0.625), acute GvHD (p=0.388), chronic GvHD (p=0.991), CMV antigenemia (p=0.550), hematuria (p=0.480). However, pulmonary complications (p=0.005) was significantly lower in CyFluATG arm. Infection rate (p=0.130) and sinusoidal obstruction syndrome (SOS, p=0.101) seemed lower in CyFluATG arm but were not statistically significant. Any RRTs were significantly higher in CyATG arm (80.0% vs. 39.5%; p In conclusion, overall treatment-related complications and survival were similar between CyATG CyFluATG, however, CyFluATG seemed superior over CyATG in terms of pulmonary complications and RRT. Disclosures: Off Label Use: Cyclophosphamide, Fludarabine and thymoglobulin were used in conditioning regimens of this phase III clinical trial.


The facile, practical synthesis of optically active N-protected allylamine from α-amino acid is described. The evolution of this work in the synthesis of statine analogue using [3+2] cycloaddition reaction is detailed


Aiming at reducing the test period of rubber damping element,the simulation on the accelerated life test of rubber vibration damper was carried out.The 3D solid and finite element model were established by the use of CATIA and ABAQUS software,adopting the bi-parameter Mooney-Rivilin model as rubber material.The loading frequency boundary of the accelerated life test was obtained by the modal analysis of rubber damping element in working state.Then stress distribution of rubber damping element under three different time-variant displacement loads was obtained by the transient dynamics analysis and consequently the position fatigue damage tends to occur was identified.Finally the damage periods in three cases were determined respectively based on the strain-life curve using Manson-Coffin.The results indicate that the test period can be shortened effectively by virtue of reasonably higher loading frequency and level with the same damage model.


Financial development can be measured in accordance with three indexes of finance—dimensions,finance—activities and finance—efficiency.The examination of the relationship between China' s financial development and urban-rural income distribution by means of OLS and GMM regression,the panel unit root,co-integration and causality test indicates:(1) There exists the Kuznets effect between the financial development and the income gaps,i.e.the so called inverted-U shape relationship.(2) The financial development scale has notably widened the urban-rural income inequality,but the strengthened agricultural loans have played an important role in helping the farmers to increase their income and narrowing the urban-rural income gap.(3) There exists a long-term balanced relationship between the level of financial development and the urban-rural income distribution;there is a one-way causality between the scale of financial development,the agricultural credit and the urban-rural income distribution,however,there is a two-way causality between the efficiency of financial development and the urban-rural income distribution.


One noted the high incidence of numerous parasitoses in natural reservoirs at the territory of the Volgograd Region. Besides it had been established increase of the infection rates in perch over the period of 2009-2010.


In May of 1999 the 121 no charging soft volleyball made by Beijing Ronglin Co. immerged to society.As to realize and use the no charging soft volleyball better,the author primarily uses experiment method,and the main result is the no charging soft volleyball compared to indoor volleyball is easier to play on service and receive.


Human parsing is one of the basic tasks in the field of computer vision. It aims at assigning pixel-level semantic labels to each human body part. Single human parsing requires further associating semantic parts with each instance. Aiming at the problem that it is difficult to distinguish the body parts with similar local features, this paper proposes a single human parsing method based on the visual attention mechanism. The proposed algorithm integrates advanced semantic features, global context information, and edge information to obtain accurate results of single human parsing resolution. The proposed algorithm is validated on standard look into part (LIP) dataset, and the results prove the effectiveness of the proposed algorithm.


Purchasing a private practice is a big decision and requires thorough preparation. The practice that you purchase can determine where you live and where your children go to school, and it ultimately shapes the lifestyle you've been dreaming about your entire life.


The reactions of arylazoxy aryl sulfones (1) with α,β-unsaturated esters and nitriles in the presence of a palladium(0) catalyst were found to give aryl-substituted esters and nitriles in good yield.


Background: Sesame oil can be used to treat cardiovascular diseases, such as atherosclerosis, by reducing the levels of fibrinogen and factor VII. The aim of this study is to prepare a microemulsion containing sesame oil as a drug nanocarrier for improving the aqueous solubility and therapeutic effects of this vegetable oil on the reduction of the fibrinogen and factor VII levels in animal model. Methods: This experimental study was performed for microemulsion preparation and animal test at Ferdowsi University of Mashhad and Cardiovascular Research Center of Mashhad University of Medical Sciences, Mashhad, Iran, respectively, from April 2015 to January 2017. To prepare the microemulsion samples, Tween 80 and span 80 were selected as surfactant couple and surfactant ratios of 8:1, 9:1 and 10:1 were determined for construction of pseudo-ternary phase diagrams. The Zealand white rabbits were categorized in three groups: receiver of base diet group, high cholesterol diet and high cholesterol diet plus microemulsion. Results: The average particle size of the samples was in the range of 16.64±0.1 to 21.16±0.2 nm with a uniform particle size distribution. Zeta potential was in the range of -10.7 to 18.4 mV, refraction index was approximately 1.39. Electrical conductivity coefficient was in the range of 297 to 311 μz and pH of all the samples were approximately 6.42 for all samples. All of the microemulsion samples were physically stable and the prepared sample with 9:1 surfactant ratio was selected to investigate the animal test due to the higher oil percentage in comparison with the other samples that be stable over 6 months. Significant decrease in the levels of fibrinogen and factor VII in the third group of rabbits was observed compared to the other groups. Conclusion: The results of this study showed the effective performance of nanostructured drug delivery systems in the form of microemulsion to improve the aqueous solubility and therapeutic effects of hydrophobic compounds such as vegetable oils. Abstract


Using Alice, Texas, as a model, a template has been developed to increase the cooperation and communication between transportation planning and economic development groups. The template establishes a foundation for coordinating traffic forecasts with projected urban/economic development plans. Currently, the two sets of information are rarely applied together in small Texas cities. Small cities above 10,000 and under 50,000 in population will benefit most from this research effort. Additionally, the template could be a useful planning tool at the Texas Department of Transportation for corridor analyses. This User's Guide presents this model for small Texas cities that will coordinate community development with future transportation plans. The process utilizes traffic and economic data in order to project where improvements need to be made to the existing transportation system.


Background and Aim: Osteoporosis is one of the most common bone diseases that is caused by an imbalance between the activity of osteoblasts and osteoclasts. Osteoprotegerin (OPG) plays an active role in inhibiting osteoclasts by binding to the receptor activator of nuclear factor kappa-B ligand (RANKL). The balance in the OPG/RANKL ratio is important in bone remodeling. The current study investigated and compared the effects of mumie extract and chemical drugs on cell proliferation, expression of OPG and RANKL in MG63 cells. Materials and Methods: The effects of 100, 200 and 300 μg/ml of mumie extract on cell proliferation, expression of OPG and RANKL in MG63 cells were investigated in experimental groups, positive and negative control groups. Data were analyzed by ANOVA test. Results: Significant increases were observed in the proliferation of MG63 cells after exposure to 100 and 200 μg/ml concentrations of mumie extract. 200 μg/ml concentration of the extract significantly decreased the expression of RANKL and increased the expression of OPG. It also increased OPG/RANKL ratio significantly in the experimental groups, compared to those in the negative control groups. Although the effects of 100 μg/ml and 200 μg/ml concentrations were similar to each other, they showed no significant effects on the variables. 300 μg/ml concentration of the extract showed a reverse and insignificant effect. Conclusion: 200 μg/ml concentration of mumie extract had a significant effect on the expression of two important factors in bone remodeling. Therefore, individuals susceptible to osteoporosis can use mumie extract as an alternative to chemical drugs. © 2018 the Author (s).


The effects of various design and fabrication parameters on the imaging characteristics of a photon sieve are analyzed. Specifically, the focusing characteristics on the focal plane of photon sieves with different arrangement of pinholes in terms of shape, orientation and angle of incidence were investigated using professional optical design software ZEMAX for the first time, which is otherwise difficult to calculate by the exact theory. The fabrication tolerances of different parameters of the photon sieves were evaluated using Monte-Carlo method.


The development of high-grade tobacco leaves was discussed in this paper.The results showed that combined with shed,it can ensure transplanting timely by using the grouing seedlings technique of het-preserving greenhouse.It can improve the security of tobacco products by popularizing environmental controlling,pesticide-residues controlling and NTRM controlling.It can improve the appearance and intrinsic quality of tobacco leaf through promoting the technology of delaying grading;the appearance quality was closely to the international main ingredient leaf,while the tasted quality had certain distance to the international main ingredient leaf.


The article develops K. Randsborg's idea, according to which the decorative elements of the Trundholm disc have the character of calendar symbols. When considering these elements in their structural and numerical groupings, astronomical and calendar significance is found for all belts of both sides of the disk, and the proposed interpretations are consistently contextual. One discloses on the right side of the disk an 8-year cycle connecting the counting of days according to the sun and to the moon, 16 transitions of the sun from winter solstice to summer solstice, and 27 weeks of the summer half of the year. The patterns represented on the left side of the disk are relevant to the night sky: the same 8-year cycle, since it refers to the counting of days not only according to the sun, but also according to the moon; either division of a year into 10 months or the 19-year cycle of the return of both the moon and sun to their common position with respect to the stars; 25 weeks of the darker, winter half of the year. One concludes that in Denmark of the Bronze Age two types of calendars were used: lunisolar, which regulated the timing of religious festivals, and a solar, so to speak, civil, with a year made up of two not quite equal half-years, 52 weeks and 364 days (probably coexisting with knowledge of a year of 365 ¼ days). The data concerning the medieval Scandinavian calendars, on the one hand, and ancient calendars of Greece and the Near East, on the other, are in perfect agreement with the above conclusions.


We introduce a simple but powerful technique to study processes driven by two or more reinforcement mechanisms in competition. We apply our method to two types of models: to non conservative zero range processes on finite graphs, and to multi-particle random walks with positive and negative reinforcement on the edges. The results hold for a broad class of reinforcement functions, including those with superlinear growth. Our technique consists in a comparison of the original processes with suitable reference models. To implement the comparison we estimate a Radon-Nikodym derivative on a carefully chosen set of trajectories. Our results describe the almost surely long time behaviour of the processes. We also prove a phase transition depending on the strength of the reinforcement functions.


Cases on Technological Adaptability and Transnational Learning: Issues and Challenges contains case studies on divergent themes of personalized learning environments, inclusive learning for social change, innovative learning and assessment techniques, technology and international partnership and transnational collaboration for enhanced access under the core domain of technological adaptability and transnational learning.


Background: Soft tissue and bone sarcomas are rare entities, hence, standardized therapeutic strategies are difficult to assess. Materials & methods: Immunohistochemistry was performed on 68 sarcoma samples to assess the expression of PD-1, PD-L1, IDO and CD70 in different tumor compartments and molecular analysis was performed to assess microsatellite instability status. Results: PD-1/PD-L1, IDO and CD70 pathways are at play in the immune evasion of sarcomas in general. Soft tissue sarcomas more often show an inflamed phenotype compared with bone sarcomas. Specific histologic sarcoma types show high expression levels of different markers. Finally, this is the first presentation of a microsatellite instability-high Kaposi sarcoma. Discussion/conclusion: Immune evasion occurs in sarcomas. Specific histologic types might benefit from immunotherapy, for which further investigation is needed.


Objective To compare the effect between low-temperature plasma knife tonsillectomy and conventional dissection tonsillectomy. Methods 90 patients with obstructive sleep apner hypopnea syndrome(OSAHS) caused by tonsil hypertrophy or adenoid hypertrophy who admitted in our hospital during June 2013 and June 2014 were randomized into plasma group(n=50) and control group(n =40) in which low temperature plasma knife tonsillectomy and conventional dissection tonsillectomy were performed respectively. Intraoperative blood loss, operation duration, postoperative hemorrhage and postoperative pain were compared between the two groups. Results The operation duration and intraoperative blood loss were both lower in the plasma group than in the control group,(15.10±3.48) mins vs(25.70±6.47) mins and(4.19±1.44) m L vs(30.56±7.64) m L, and the differences were statistically significant,P0.05; the postoperative pain of the patients in the plasma group was obviously less than that in the control group,P0.05; there was no statistically significant difference in the rates of postoperative hemorrhage, 8.0% vs 5.0%, between the plasma group and the control group,P 0.05. Conclusion Low-temperature plasma knife tonsillectomy is characterized by less bleeding and postoperative pain, shorter operative time, quick recovery, and higher security.


Background: Natural Language Processing (NLP) for ascertainment of childhood asthma based on Predetermined Asthma Criteria (PAC) using free text in the EMR was successfully developed and validated. However, the approach has not been applied to adult-onset asthma. Objective: To assess whether PAC-based NLP algorithm (NLP-PAC) identifies adult-onset asthma as effective as childhood asthma. Methods: We applied NLP-PAC to EMR of adult cohorts (Olmsted County, Minnesota, residents) who participated in multiple population-based studies. We excluded asthma that occurred before 2000 when EMR was first implemented at our study setting. The study subjects' asthma status was ascertained by applying PAC through manual chart review by abstractors. The performance of NLP-PAC was assessed by determining concordance of asthma status between NLP-PAC and manual chart review as gold standard. Results: The cohort consists of 1,898 subjects, 56% were female, and the median age at the last follow-up date was 65 years (IQR: 55-76). Manual chart review identified 97 subjects (5.1%) with adult-onset asthma. NLP-PAC ascertained 98 subjects (5.1%) as asthma with 89 of them overlapped with manual chart review. The sensitivity, specificity, positive predictive value, and negative predictive value of NLP-PAC were 91%, 99%, 90%, and 99%, respectively. Conclusion: Leveraging NLP to automated chart review for asthma ascertainment in adults is as effective as that implemented in children. Our NLP-PAC will be a useful tool enabling large-scale clinical studies for research and population management for asthma care.


A 16-year-old girl presented to the dermatology department with spiny verrucous lesions all over her body since the age of 2 months. Her condition had begun as small, dark brown, spiny, and warty lesions on her left forearm that gradually became darker, and more warty and spiny. Subsequently, similar lesions appeared and eventually covered the majority of her body surface by 1 year of age. The patient was born through a full-term, normal vaginal delivery, with no history of consanguinity. There was no history of collodion at birth, pruritus, blistering, erythroderma, or skin fragility. There was no history of seizures, mental retardation, fractures, trauma to the knees, visual or hearing defects, or any other major abnormalities, and the patient had normal developmental milestones. Family history was negative. She gave history of partial shedding of skin lesions all over her body after scrubbing and reappearance which occurred cyclically every 2-3 weeks since 1 year of age. The patient also had gradually progressive bilateral valgus knee deformity associated with pain and difficulty in walking since the age of 9 years. On examination, the patient was shorter for her age (138 cm, <3rd centile). The skin showed diffuse, hyperkeratotic, thick, hyperpigmented, malodorous, spiny, and verrucous ridges all over her body with relative sparing of back, neck, upper chest, axillae, face, scalp, popliteal fossa, antecubital fossa, and umbilical region (Figures 1 and 2). Diffuse palmoplantar keratoderma with fissuring was seen (Figure 3). Hair, nails, teeth, mucosa, and systemic examination were normal. On laboratory examination, serum calcium was 8.3 mg/dL (normal 8.5-10.2 mg/dL), serum phosphorus 2.9 mg/dL (normal 2.54.5 mg/dL), serum alkaline phosphatase 565 u/L (normal 38-126 u/L), 25-hydroxy-vitamin D3 levels 4.1 ng/mL (normal < 20 ng/mL), serum parathormone 98 pg/ml (normal 14-72 pg/mL), and urinary calcium excretion 135 mg/day (normal 100-250 mg/day). Radiograph of the lower limbs showed genu valgum deformity in both knees. A biopsy from skin lesion over the trunk was taken (Figure 4).


Mineralized specimens (2 to 10 μg) were dissolved in acetate buffer and fluoride was estimated electrometrically under nonequilibrium conditions in the range of 0.5 to 5 ng; no reagents were added to the solution. In this method, which can be applied to all biologic calcified specimens, a technique is used for increasing the sensitivity of the ion electrode.


Background: Globally, colorectal cancer is the third most common cancer among men and the second most common among women. Colorectal cancer is the fourth most frequently diagnosed cancer, but the second-leading cause of cancer deaths. Incidence of colorectal cancer has decreased significantly in recent decades, mortality rates have fallen as well. Those declining rates are largely attributed to earlier diagnosis through screening and more sophisticated and effective methods of treatment. Objective: That work represents colorectal cancer metastasis management, early detection and screening of colorectal cancer. Subjects and Methods: This observational study was conducted on 10 patients with liver metastasis admitted to GIT Surgery Unit, Cancer National Institute and postoperative follow up and observation at El-Haram Hospital and Cancer National Institute between April 2017 and December 2017. Results: This work is observational study. The patients in this study were divided into two (2) groups: group 1 and group 2. The included patients were prepared through studying the patient's condition, preoperative & intraoperative assessment. Choice of operation and how to manage synchronous metastases. The type of resection does not seem to influence the prognosis if a clear margin is obtained. The carcinoembrionic antigen (CEA) level is strongly correlated with recurrence-free survival. A free margin of at least 1 cm offers the best chance of avoiding recurrence. Conclusion: In this work observational study results preoperative, operative and postoperative results were recorded. Operative results (type of surgery, surgical technique), postoperative results (liver related complications, general complications, and postoperative morbidity and mortality of liver resection of colorectal cancer. Prognosis and follow up of patients of study and postoperative recurrence.


The invention proposes a device for fitting a guide unit on a first furniture part which is guided for movement in relation to a second furniture part, wherein the guide unit comprises a fixed rail, which is arranged on the second furniture part, and a movement rail (2), which is arranged on the first furniture part. According to the invention, the device is designed for a movement rail (2) which is provided, at the rear end, with a hook element (3) with a hook nose (5) for fixing the first furniture part in the rear region. Also provided is an adjusting device (1) with an accommodating device (7) for engagement of the hook element (3), this device being located, in an assembled state, on the first furniture part, and the hook element (3) therefore engages in the accommodating device (7), it being possible to adjust the accommodating device (7) on the adjusting device (1) in at least one direction in space.


The invention relates to a method implemented by an electronic unit of a vehicle, comprising the steps of: - controlling at least one transmission, by a vehicle communication module, a polling frame (CAP) in within an electromagnetic signal having a first range (P0); - receiving a response frame (REP) from an identifier; - initiation exchange (EM, REC) of data between the communication module and the identifier; - after a predetermined time of exchange, controlling at least one transmission by the communication module, a polling frame (CAP) within an electromagnetic signal having a second surface (P1) lower than the first range (P0).


What does the result of Italy's constitutional referendum mean for the country moving forward? Valentino Larcinese argues that the vote should be seen as a positive development for Italian democracy, albeit one that has opened up deep divisions which will take time to heal.


Dimer models have been the focus of intense research efforts over the last years. This paper grew out of an effort to develop new methods to study minimizers or the asymptotic height functions of general dimer models and the geometry of their frozen boundaries. We prove a complete classification of the regularity of minimizers and frozen boundaries for all dimer models for a natural class of polygonal (simply or multiply connected) domains much studied in numerical simulations and elsewhere. Our classification of the geometries of frozen boundaries can be seen as geometric universality result for all dimer models. Indeed, we prove a converse result, showing that any geometric situation for any dimer model is, in the simply connected case, realised already by the lozenge model. To achieve this we present a new boundary regularity study for a class of Monge-Ampere equations in non-strictly convex domains, of independent interest, as well as a new approach to minimality for a general dimer functional. In the context of polygonal domains, we give the first general results for the existence of gas domains for minimizers. Our results are related to the seminal paper "Limit shapes and the complex Burgers" equation where R. Kenyon and A. Okounkov studied the asymptotic height function in the special class of lozenge tilings and domains. Part of the motivation for development of the new methods in this paper is that it seems difficult to extend those methods to cover more general dimer models, in particular domino tilings, as we do in the present paper. Indeed, our methods prove new and sharper results already for the lozenge model.


In Freudian psychoanalysis, Oedipus complex refers to the attachment, usually to the extent of sexual desire, of a son to his mother. It typically occurs during the son's age of three to five years old and is said to be a precursor of future romantic attachment styles. If left unresolved, the Oedipus complex will lead to social interaction defects. With the above premise, this research determined the role of Oedipus complex on the perceived romantic security of male students. Data for this mixed explanatory methodology research were obtained through purposive homogenous sampling design with 51 male students engaged in a romantic relationship as the main respondents of the study. Using descriptive and multiple linear regression analysis, the researchers established the impact of Oedipus complex on perceived romantic security. It was revealed that there existed an adverse effect of Oedipus complex on perceived romantic security such that as they become more attached to their mothers, the more is the tendency for them to develop anxiety concerning their relationship status. The study concluded that the Oedipus complex is one of the factors that affect the perceived romantic insecurity of males. The authors recommend further investigations on the aspect of unresolved Oedipus complex since their data regarding it is limited.


The research,development,and application of the ultra-supercritical steam turbine heat-resistant steel were presented,including development,microstructure,strengthening mechanism,mechanical property,heat treatment and application of the steel.The problems during research process of the steel were also presented.Combined with the future progress of ultra-supercritical steam turbine technology,the prospects for the study of ultra-supercritical steam turbine heat-resistant steel are revealed.


A program of psychotherapy provided by the Department of Psychology to inmates at the Montana State Prison is described. Graduate students are used as therapists in group and individual therapy sessions. About 25% of the prison population of 250 men is serviced by 2 graduate students who visit the institution twice a week and by 3 faculty consultants who participate in the program approximately once a month. Success of the program as measured by inmates' attendance at the voluntary meetings and by the perceived attitude change of the correctional officers toward the therapists indicates that the program is having a positive effect on the institution.


The invention concerns a method which consists in placing a fibrous structure for forming a reinforcement of the part to be produced in a mould (22) having a wall at least formed by a flexible membrane, then injecting in the mould a resin composition having a weight ratio of volatile materials less than 25 % and a temperature of a value such that its viscosity ranges between 0.1 Pas and 0.3 Pas. The polymerization of the resin is carried out in the mould placed in a chamber (20) while gradually raising the temperature and comprises at least one final polymerization phase under pressure to obtain a part made of composite material exhibiting a residual volume porosity less than 11 %.


Abstract How is Germany doing with respect to the fight against COVID-19? Did the German Federal and the country's Regional Governments enact a coordinated approach, and did the sector have the opportunity to co-operate with government and have a "voice" in the policy process? Based on the results of recent empirical studies and desk-top, internet-based research, these questions are addressed and the outcome is that there were numerous programs issued by the Federal and regional German governments that buffer the effects of the crisis is having on the sector. However, the programs were not developed in co-operation with the sector and were not easy to access, particularly for small and non-professionalized nonprofits.


The areas of distribution of 24 species of Mediterranean-stepic character (included in this term are Ibero-Mogrebine, Irano-Turanian, Saharo-Sindian species, as well as species endemic to arid peninsular zones), are delimited, of which the nordeast boundary in the Iberian Peninsula is placed in the Catalonian Region. In the elaboration of these areas, unpublished data collected by the authors has been
used, as well as data gleaned from bibliographic references and herbarium material.


Abstract We give a characterization of cotilting modules over Prüfer domains, up to equivalence; moreover we show that tilting modules over Prüfer domains are of projective dimension at most one.


The main factors of the processes of the carbon dissolving in iron melts are analyzed on the basis of different physical-chemical approaches. The calculations of parameters of the dissolving processes of powders of different fractional structure in iron melts are carried out.


Abstract An analytical method combining flow-injection analysis (FIA) with thermal-lens spectrometry (TLS) has been developed for high-throughput and sensitive analysis of cefoperazone (CPZ) in tap water and urine samples. The method is based on the indirect determination of CPZ through its alkaline oxidation with KMnO4. The performance of FIA-TL was validated for the determination of CPZ in the samples. The experimental parameters affecting the reaction were studied and optimized by a multivariate method. The calibration curves for the determination of CPZ were obtained considering the optimum values of the parameters. The detection limits were 2.70·10−7 mol L−1, 4.88·10−7 mol L−1, and 1.89·10−7 mol L−1, in standard solution, tap water, and urine, respectively. This work reports a new solid-phase extraction (SPE) procedure for the analysis of urine. The accuracy of the analytical method was assessed by spike and recovery experiments. The precision was evaluated with inter-day and intra-day trials. The FIA-TLS method shows advantages over the batch conventional operation, such as high sensitivity, simple processing, low volume consumption, and high sample throughput (60 samples hr−1). The optimized FIA-TLS method may be applied for fast and sensitive quantitation of CPZ in real samples in flowing media.


4. roy m. prendergast, Film Music: A Neglected Art (New York: W. W. Norton, 1992). 5. Theo Van leeuwen, Speech, Music, Sound (basingstoke: macmillan, 1999); Jean-Jacques Nattiez, Music and Discourse: Towards a Semiotics of Music (princeton, N.J.: princeton university press, 1990). 6. Nicholas Cook, Analysing Musical Multimedia (oxford: oxford university press, 1998). 7. John Fiske, Television Culture (london: routledge, 1987); Reading the Popular (london: routledge, 1989); Jane Feuer, "genre study and Television" in Channels of Discourse, Reassembled, ed. robert C. Allen (Chapel Hill: university of North Carolina press, 1992), 138–60; "melodrama, serial Form and Television Today," in Television: The Critical View, ed. Horace Newcomb (oxford: oxford university press, 1994), 551–62; John Thornton Caldwell, Televisuality: Style, Crisis and Authority in American Television (New brunswick, N.J.: rutgers university press, 1995); glen Creeber, Serial Television: Big Drama on the Small Screen (basingstoke: macmillan, 2006); Creeber, Dennis Potter: Between Two Worlds (basingstoke: macmillan, 1998); and Creeber's edited collections The Television Genres Book (london: bFi: 2001) and Tele-Visions (london: bFi, 2006); Todd gitlin, Inside Primetime (los Angeles: university of California press, 2000). 8. michel Chion, Audio-Vision: Sound on Screen, ed. and trans. Claudia gorbman (New York: Columbia university press, 1994), 178.


This report is a description of the operational development of the commuter transportation brokerage system that was in operation in Knoxville, Tennessee through 30 June 1977. When the Knoxville Commuter Pool (KCP) was established, the concept of a transportation broker came into effect with the intention that if it proved workable, it would become an arm of the proposed City Department of Transportation. The initial purpose of this research was to develop and operationalize an multi-modal public and private transportation service throughout the Knoxville metropolitan area. The instrument through which the project objectives would be obtained was the transportation broker who could coordinate all modes of transportation. The broker would not promote one mode of transportation over another, but would promote all modes in order that the broad objectives of the community would be met. Each individual commuter or group requesting service would be provided with a series of transportation alternatives that permitted the highest level of service at the lowest possible cost. These alternatives included vanpooling, which this study addresses extensively. KCP is now working under the City Department of Transportation, and its future plans include a continued effort to find better ways to promote all forms of ridesharing. There was not time to realize the full potential of the brokerage concept by 30 June 1977. However, sufficient accomplishments were achieved to show that the brokerage concept has the potential of solving many of the transportation problems with which cities are now faced. /UMTA/


: The Australian Bureau of Meteorology has embarked on a 10-year research plan focused on Earth System Modelling. A unified modelling system supporting all forecast products and services will drive efficiency gains, improve product consistency and remove the maintenance burden of disparate systems now in operation. A physically based hydrological model will underpin the two seasonal hydrological forecasting services provided by the Bureau: The Australian Water Outlook (AWO) and the Seasonal Streamflow Forecasting (SSF) service. Currently each service is supported by a separate forecasting system. The AWO service provides seasonal forecasts of root-zone soil moisture, runoff and AET using the Australian Water Resources Assessment model (AWRA). AWRA is a 5km2 distributed land surface model and underpins the AWO. Calibrated ACCESS-S (vS2) seasonal climate forecasts provide the necessary climate forcing. The current Seasonal Streamflow Forecasting (SSF) service provides forecasts at discrete point-locations that coincide with river gauging stations and major water storages. Seasonal streamflow forecasts are based on a Bayesian Joint Probability (BJP) statistical model that relates current catchment conditions (antecedent observed monthly flow, Qobs) and the current climate state (climate indices) to the likely streamflow in a forthcoming three-month period. To integrate the two services, BJP post-processing is instead applied to AWO seasonal forecasts to generate seasonal streamflow forecasts. The BJP statistical model provides the joint probability of simultaneous outcomes (streamflow at three monthly lead-times) given a set of defined input variables. Separate statistical models are defined for each month of the year at up to 481 forecast locations (site-month pairs). Statistical post-processing is applied to both root-zone soil-moisture (conceptually equivalent to catchment antecedent conditions) and runoff (conceptually similar to river discharge, albeit in error and requiring a form of error correction). Forecast skill, calculated as the Cumulative Rank Probability Skill-Score (CRPS-S), is then compared to forecast skill obtained from a benchmark model: use of observed antecedent streamflow (Qobs) only to predict streamflow. Median forecast skill is maximised if the AWO forecast variable with the highest forecast skill is selected for each site-month combination. For each month of the year, median forecast skill is either statistically equivalent to or significantly increased from the benchmark model. A threshold of +/- 5% CRPS-S around the benchmark model forecast skill reveals ~66% site-month combinations show either an equivalent forecast skill or increased forecast skill compared to the benchmark model. Similarly, a threshold of [-5%, +5%] defined as forecast skill equivalent to a historical climatology reveals 90% of site-month combinations have either an equivalent or positive forecast skill. Streamflow post-processed forecasts perform particularly well during high-flow seasons, where rainfall is perhaps the predominant input forcing that elicits a hydrological response. Conversely forecast performance drops during the low-flow seasons in certain regions (e.g. SW WA and the northern Australia), where rainfall perhaps ceases to significantly impact streamflow and other hydrological processes predominate. These hydrological processes may be absent in AWRA, thus resulting in little inter-annual variation during the low-flow season in either root-zone soil-moisture or runoff. Due to hydrological persistence, observed antecedent conditions provide a particularly high-level of forecast skill during the low-flow season. The spatial and seasonal variation in which either root-zone soil-moisture or runoff maximises forecast skill remains a subject of investigation. This study demonstrates a comparable level of forecast skill between statistical post-processing of AWO seasonal forecasts and the current operational service. Acceptable forecast skill is possible without a dependency on Qobs.


Si· ~ Sj) n , making these states seemingly unrealistic on bipartite lattices, where one expects a simple antiferromagnetic order. We show that those interactions can be generated by orbital physics in multiorbital Mott insulators. We focus on t2g electrons on the honeycomb lattice and propose a physical realization of the spin-3/2 AKLT state. We find a phase transition from the AKLT to the Neel state on increasing Hund's rule coupling, which is confirmed by density matrix renormalization group (DMRG) simulations. An experimental signature of the AKLT state consists of protected, free spins-1/2 on lattice vacancies, which may be detected in the spin susceptibility.


The constant reduction in the components size of integrated circuits, as well as higher operating frequencies, increases the vulnerability to internal and external noise sources. These noises can cause a failure in any component, affecting the functioning of the system as a whole. Systems-on-Chip (SoCs) with dozens of cores are based on Networks-on-Chip (NoCs), and require networks that are able to detect and prevent a fault in leading to a system failure and an application malfunction. In this context, this work aims at evaluating solutions to increase the reliability and availability of a NoC, implementing mechanisms for error detection and correction. Spatial and information redundancy techniques were applied in order to protect the network against Single Event Upset (SEU) faults. The applied techniques ensured the correct operation of the network in the presence of faults, with low impact to the performance and with acceptable silicon costs.


In the context of a profound crisis in the Venezuelan health system, diverse initiatives on the part of civic society have emerged which offer health servic...


When is a single slide preparation never 1 slide? When it is reviewed on an image-assisted screening device. This is the ''new math'' of image-assisted workload recording. On July 27, 2010, the US Food and Drug Administration (FDA) released an alert clarifying workload recording for semiautomated gynecologic cytology screening devices. The alert specifically assigns a ''value'' of 0.5 for any slide that is reviewed on an image-assisted screening device using fields of view (FOV) only. When a manual review is necessary, the slide is assigned a full slide ''value''. Therefore, those slides that undergo evaluation using only FOV are considered half (0.5) of a slide, whereas those slides that undergo FOV examination plus manual review are considered 1.5 slides. One slide never equals 1 when reviewed with image assistance. The alert was in response to confusion over workload instructions from manufacturers and the FDA. The FDA workload assessment for FOV was clear. The integration of the manual review component after FOV was confusing. The FDA approval for ThinPrep Imaging System (TIS) (Hologic, Bedford, Massachusetts) allowed 200 slides per 24 hours not to be screened in less than 8 hours. The Sure Path Focal Point Guided Screening Imaging System (BD Diagnostics, Franklin Lakes, New Jersey) was approved for 170 slides per 24 hours in no less than an 8 hours. The sentences dealing with subsequent manual review were open to interpretation. For ThinPrep Imagers, ''The workload limit of 200 slides includes the time spent for manual review of slides that is not to exceed 100 slides in an 8-hour workday.'' For SurePath, ''Manual workload limit does not supersede the CLIA requirement of 100 slides in no less than an 8 hour day per 24 hour period.'' So how were laboratories counting slides? Some cytology laboratories were keeping separate workload statistics, making sure that the total slides per hour never exceeded 12.5 for manual or 25 for image-assisted. Other labs would perform all reviews on the imagers and make sure that the total slides over the course of 24 hours never exceeded 200 (for TIS) or 170 (for Focal Point) and that the manual workload was never more than 100 (prorated for the hours worked.) Other cytology laboratories had converted their entire volume of Papanicolaou (Pap) tests to image-assisted screening devices and, therefore, felt that if 100 manual reviews were not performed, the maximum workload of 200 or 170 slides could be reviewed per technologist in a 24-hour time frame. Record keeping was complex and confusing. In fact, inspectors from laboratory accrediting agencies interpreted the guidelines differently, and laboratories could be cited for deficiencies in workload recording depending upon the inspecting organization. As a result, the FDA issued the alert to clarify the method of counting slides for image-assisted screening. When 1 slide becomes either 0.5 or 1.5, there is no room for misinterpretation.


The paper deals with the problem of the economic efficiency of outsourcing of organization of transport processes. It presents the results of the research studies from the literature and also research made with the use of an electronic model of economic benefits of cooperation with an external service provider. The model was developed by the Author of the paper and was used to make simulations of different strategies from the perspective both of a carrier and a transport user. According to the results profitability depends rather on the parameters of a process of delivery of goods – average demand, standard deviation, weight and value of transported commodities than on the costs of transport. to variant productivity" the logistics costs reduction is relatively bigger in case of cheaper than in case more expensive what can be a proof, that economizing on bring small


ABSTRACT Background — While conceptually straightforward, placing point-to-point contiguous radiofrequency lesions to achieve pulmonary vein isolation (PVI) is technically challenging in patients with paroxysmal atrial fibrillation (PAF). Furthermore, chronic efficacy is limited by late PV reconnections. A novel compliant balloon ablation catheter (BAC) able to deliver visually-guided short arcs/spots of laser energy was tested in initial pre-clinical and clinical cases to determine if visual guidance could predict reliable and persistent PVI. Methods and Results — This study consisted of i) an experimental porcine phase with both acute (n=15 pigs) and 4-week chronic (n=10) data, and ii) a single-center clinical feasibility phase (n=27 PAF patients), again with acute and 3-month chronic data. Under endoscopic guidance, point-by-point peri-venous ablation was performed in a contiguous and overlapping manner. Each porcine PV was longitudinally sectioned for detailed histological analysis. At 3-months post-ablation, patients underwent a pre-specified remapping procedure regardless of symptomotology. In the acute and chronic animals, 29/30 (97%) PVs were electrically isolated after placing the


This study evaluated the fluorine removal capacity of half-burnt dolomite and examined the removal mechanism. As the result of examining the burning conditions of dolomite, it was found that dolomite burnt at 1023 K for 4 h has the highest performance. It turned out the fluorine removal mechanism that CaCO3 does not contribute to reaction and that fluorine is sorbed with hydration of MgO. As the result of comparing removal capacity by changing the initial pH of fluorine solutions, it was found that performance is reduced in the strong alkaline solution.


This paper describes variation characteristic on gain index values in automatic gain control of receiver based on measurement to building entry radio propagations in mm-wave band. The measurement campaign has been conducted to two different buildings within the research institute in Daejeon, which was selected to represent concrete buildings with either traditional or specific glass material. As results, we found that variations of gain index values of receiver were dependent on the pathloss as well as concrete building structures including glass materials affecting to multipath.


This paper develops a general superconvergence result for the least- squares mixed flnite element approximations of general second order elliptic problems using a least-squares surface fltting method proposed by Wang in (9). The corresponding superconvergence of least-squares mixed flnite element method is established on general quasi-uniform flnite element partitions and can be extended to general problems based on the flrst-order systems.


Using data involving free-body diagrams on final exams from a first year Mechanics I course, a broadly defined rubric was created which assesses free body diagrams in six separate categories: overall quality, forces/moments, body, axes, dimensions, and resulting equations. Data from 238 free-body diagrams and equilibrium equations were then assessed. Results of the study found that 45% of the equilibrium equations had errors in them of which 67% of those errors were a direct result of errors from the free-body diagrams. Quantitative data on frequency and types of errors found in students' free-body diagrams are provided and discussed.


Background: In a multi-centre study titled 'Treatment of Early Neuropathy in Leprosy' ('TENLEP'), monofilament testing (MFT) was used for the detection of touch pressure sensibility impairment (TPSI). It was recommended to use three test sites each for median, ulnar, radial cutaneous, sural and posterior tibial nerves. Aim: To assess the possible increase in detection rate of TPSI by increasing test sites for ulnar, median and posterior tibial nerves. Method and subjects: For the ulnar nerve, two sites were added in the area supplied by its dorsal cutaneous branch. For the median and posterior tibial nerve, one site each was added on dorsum of the index finger and heel respectively. Bilateral nerves were tested in a total of 70 leprosy patients. Findings: The addition of two extra test sites on the ulnar nerve resulted in the detection of TPSI in an additional 41 (29%) of the 140 nerves tested. Similarly for the median and posterior tibial nerves, the addition of one test site each detected TPSI in an additional 21 (15%) and 23 (16%) nerves respectively. Conclusion: The study showed that the addition of five test sites divided over three nerves, the ulnar, median and posterior tibial nerves, improved the detection of TPSI by 20%.


The article discusses the role of, and the political debate on, religion in the legal sphere by, first of all, reflecting on the normative order of German religious constitutional law (Religionsverfassungsrecht). Religious freedom has to be guaranteed in both versions, the positive and the negative one. Thereby, it asks for a concept of (formal) law including the very idea of law besides traditional Natural Law theories and reductionist views on legal positivism. For that, it is necessary to neutralize the myth of neutrality in civil society as well as to be aware of the surplus of meaning and the limitations of formal procedures in the legal sphere.


Amyloidosis is a heterogenous group of often fatal disorders characterized by extracellular deposition of a proteinaceous material with a unique fibrillar form in various tissues and organs. Deposition of amyloid may cause widespread dysfunction of the involved organs. A secondary amyloidosis is AA amyloidosis and rheumatoid arthritis is one of the main underlying disease. We report a case of secondary amyloidosis in a 52 year old woman with rheumatoid arthritis. She had suffered from rheumatoid arthritis for 17 years and her hands and feet were deformed. She was presented with oliguric acute renal failure. She was confirmed by showing apple green birefringence under the polarized microscope with Congo-red stain through renal and rectal biopsy. We couldn't find any previous report of the secondary amyloidosis among the patients presenting oliguric acute renal failure without proteinuria in the Korean literatures.


Abstract Hall effect and resistivity measurements have been made on undoped n-type and Cd-doped p-type GaAs crystals irradiated with electrons at 287°K. For 1 MeV irradiations, the dose dependence of carrier removal and mobility in n-type suggests that a defect energy level at E c-0.1±0.015 eV was introduced by irradiation and was the upper level of a doubly charged acceptor. A donor level was also found in n-type at approximately E c − 0.20 eV, and deeper acceptor levels were also introduced. In p-type a similar study located a radiation introduced level at E v +0.1 ± 0.015 eV, which could be a singly or doubly ionized donor. Measurements of the carrier removal rate in p-type as a function of beam energy were in good agreement with those previously reported for n-type, thus confirming the displacement energy of 17–18 eV. It is suggested that the majority of displacement events gave rise to electrically active defects.


Although the severity of periodontal disease is known to be affected by host age, the pathological role of aging in periodontal disease, and especially that attributable to trauma from occlusion, has not been well-characterized. Interleukin (IL)-1β is a key mediator involved in periodontal diseases, a potent stimulator of bone resorption. Furthermore, it is produced by human periodontal ligament (PDL) cells in response to mechanical stress. To investigate the age-related changes in the biosynthetic capacity of IL-1β in PDL cells, we examined the effects of in vitro cellular aging with mechanical stress on IL-1β protein and gene expression by human PDL cells. Human PDL cells (young = 5th or 6th passage; old = 18-20th passage) were cultured on flexible-bottomed culture plates, and the cells were deformed at 6 cycles per min at 2 steps of tension force for 1 to 5 days. We found a two-fold increase in IL-lp production by old PDL cells subjected to mechanical tension compared with that by young PDL cells, although the constitutive levels of IL-1β were similar in both the young and old PDL cells. This increase was tension-dependent. IL-1β mRNA was also detected in both the cell types under basal conditions, and its expression was further enhanced by application of mechanical tension by use of reverse-transcription-polymerase chain-reaction (RT-PCR) and in situ hybridization methods. The increase in signal rate was higher in the old cells than in the young cells. IL-1β-converting enzyme mRNA remained unchanged. It is possible that a large amount of IL-1β produced by PDL cells from an aged host in response to mechanical force may be positively related to the accleration of alveolar bone resorption.


This study investigated on income and value chain activities in informal solid waste collection in Tandale, Dar es Salaam. The study involved the samples of 83 individuals using a non-probability purposive technique. Data was collected using a closed questionnaire and open ended interview guide. Data was analysed using descriptive statistics. The study established that the youth engaged in the informal solid waste collection without knowledge and skills on the use of personal protective equipment in executing the waste collection. Young people engaged in the informal solid waste collection regardless their gender age and education status. However, participation varied according to gender as males highly engaged compared to females. The decrease of number of waste collector was proportional to the increase of age. While primary education holders were leading in the informal solid waste collection, even university graduates participated. While the youth engaged in the informal solid collection were less respected by community members, they perceived source of income as a driving factor for engaging in solid waste collection. However, the amount generated was very minimal for sustainability especially in undertaking obligatory life requirements such as food, health care and personal servings. The study recommends that the government should set appropriate policies and strategies in running waste management so that it can attract all age groups as a source of employment.


Objective To study the correlation of nucleolar argentophil protein(AgNORs) between lymphocyte chromosomes and lung cancer cells.Methods AgNORs were examined by silver straining technique in 98 cases of lung cancer patients (adenocarcinoma 36;small cell cancer 31;squamous cell carcinoma 31) and 40 cases of the control group.Results (1)AgNORs counts of lymphocyte chromosomes in adenocarcinoma,small cell cancer and squamous cell carcinoma were 9.01±0.51,8.26±0.42 and 7.74±0.38,respectively,significantly higher than that in the control group(6.98±0.46,P0.01).(2)AgNORs counts of lung cancer cells in the 3 groups of lung cancer were 6.97±0.98,5.94±1.03 and 5.15±0.67, respectively,significantly higher than that of the normal cells(P0.01).(3)AgNORs counts of lymphocyte chromosomes and lung cancer cells in adenocarcinoma were significantly higher than those in small cell cancer, and those in small cell cancer were higher than those in squamous cell carcinoma.In the 3 groups of lung cancer,AgNORs counts of lymphocyte chromosomes were positively correlated with those of lung cancer cells and the correlation coefficients were 0.91,0.89 and 0.84,respectively(P0.01).Conclusion AgNORs counts of lymphocyte chromosomes and lung cancer cells in lung cancer were parallel to chromosome instability.Hence,AgNORs count of lymphocyte chromosomes has important significance for judging histological type of lung cancers.


In the late 1990s an idea was conceived of creating a multimodal internet-based traffic information service for the Stockholm region. The service was launched as www.trafiken.nu, a name that is still used and reflects what it offers – the current traffic situation, for all modes of transport. The stakeholders behind the website include: Stockholm Public Transport, the City of Stockholm and the Swedish Road Administration. In September a multimodal journey planner will be integrated into Trafiken.nu. This function will enable comparisons for journey times, cost and environmental impact of journeys made by car, public transport, bike, walking and a combination of these.


The purpose of the present study was to investigate the test-retest reliability of force-time derived parameters of an explosive push up. Seven highly strength trained males participated in two independent trials, separated by 48 hours, and completed six maximal effort explosive push up trials on dual mounted Kistler force platforms. Subsequently, various performance parameters were calculated. Systematic and random error was assessed to evaluate intersession reliability, together with coefficient of variation (CV) and typical error (TE). No systematic bias was detected between trials for any parameter. Moderate to high reliability was observed for the majority of variables (CV= 0.7-8.7%), with the exception of peak displacement and contact time (CV= 13.8-15.8%). Average and peak force and power measures exhibited the highest reliability (CV= 0.1-8.7%). Findings establish that selected force platform derived kinetic and kinematic parameters of an explosive push up are reliable in highly strength-trained individuals.


Licensing is an important business model within the drug development industry. Recently license contracts have become extremely complex, including sublicensing, co-development, or profi t sharing. Traditional rules of thumb are not suffi cient anymore as guidelines in negotiations of deal terms. The authors explain an easy-to-understand model that enables business developers to negotiate fi nancial terms that are fair for both parties.


Negativeandstigmatizingbeliefsregardingmentalhealthnursingdiscreditthevaluablecontributionsofmentalhealthnurses,but more importantly, these beliefs discredit the needs of people who accessmentalhealthcare.Thestigmaassociatedwithmentalhealth nursing, however, has received little attention in the literature. In this article, the author explores the stigma associated with mental healthnursingfromacriticallens.Recommendationsareproposed to address the stigma associated with mental health nursing and mental illness, concurrently, within nursing education.


The present doctoral dissertation aims at giving a tool to primary school teachers for both teaching and assessing (french) spelling. It offers a valuation set made up of 10 dictations, each of them comprising 15 ability tests, similar at all 4 levels of primary teaching where syntactical spelling as such is taught, viz 2nd to 5th forms. The quantitative and qualitative data drawn from children's answers have been thoroughly analysed; this leads to a proposal towards progressive scales of learning and evaluation, both of them, though not parallel, being geared towards a bettered performance in syntactical spelling.


Abstract A new type of modified PbTiO3 piezoelectric ceramic materials added with Pb(Mn1/3Sb2/3)O3, CaCO3, Bi2O3, NiO has been investigated. The typical composition of these materials is Pb0.80Ca0.20[(Mn1/3Sb2/3)0.05Ti0.95]O3 added with 0.5wt%NiO and lwt%Bi2O3. Under optimized fabrication processing, its main performance parameters are described as follows: Kt=0.61, Kp≌0, d33=70×10-12C * N-1; ϵ33 T/ϵ0=161, tg δ =0.01; Qm=43, Nt=2004Hz * m.


The term Home Automation refers to the automatic control of household features activity and appliances. It means this features of activity are controlled by using internet to make life more convenient. It is a set of hardware electronic and communication that work to integrate devices with one another by the use of internet. This paper describes a smart home automation system with the help of QR codes. QR Code has been used to switch "on" and "off" the light bulb by using mobile scanner application. A Mobile Scanner application has been designed for this project to scan QR codes, and this application has been designed for android mobile. The NodeMCU has been used to control the light bulb. After scanning QR code the Android application sent the command to web based application. NodeMCU is already connected with the internet and fetching command in real time with web based application. The two types of commands are used with the help of programming I.e. on and off. So what type of command has been received by NodeMCU, depending upon what type of QR code has been scanned by the user. This system and project is very unique and can be easily process anywhere in the world while scanning the QR Code with develops secure application.
KEYWORDS: IoT, QR Codes, Automation System


The Nitric Oxide Synthase inhibitory activity of two dietary phytocompounds naringenin and quercetin that belong to the family of flavonoids was studied by spectroscopic and computational methods. The determining role played by the global reactivity parameters that were calculated using spectroscopic and computational methods were correlated with the Nitric Oxide Synthase inhibitory activity by a Quantitative Structure–Activity Relationship (QSAR) study. The inter and intramolecular charge–transfer interactions responsible for the biological activity of naringenin and quercetin were studied using Natural Bond Orbital Analysis. The reactive sites of the title compounds were studied using their molecular electrostatic map. The likelihood of naringenin and quercetin to be a small drug molecule was determined by Lipinski's rule. The molecular dynamics and docking studies were carried out to test the energetic and structural favorability of the inhibition of Nitric Oxide Synthase by small drug molecules naringenin and quercetin. Experimental cell culture-based in vitro assays were done to test theoretical predictions. A QSAR study revealed that for Nitric Oxide Synthase inhibitory activity to be better, the compounds belonging to the family of flavonoids ought to have a more negative ionization energy and chemical softness while bandgap and electrophilicity index ought to be more positive.


The invention relates to an intelligent agricultural robot moving platform, in particular to the moving robot platform which is based on the machine vision technology and applied to a farmland environment or an orchard environment. The moving platform comprises a four-wheel rear-drive moving platform body and an embedded type automatic control system. The embedded type automatic control system is capable of simultaneously controlling a rear-drive traveling mechanism to move forward, a front-mounted steering mechanism to divert directions and a grabbing mechanism to grab an object. The four-wheel rear-drive moving platform body comprises a carrier compartment, the rear-drive traveling mechanism, the front-mounted steering mechanism and the front-end grabbing mechanism. The intelligent agricultural robot moving platform can serve as a teaching experimental platform, a feasible implementation scheme and performance analysis are provided for research and development of intelligent machines for the facility agriculture, and greater possibility for accelerating the development of the facility agriculture is provided.


We present a comparative study between the Bragg incidence or Low incidence XRay diffraction (1) and the electron diffraction. We have choosen well known epitaxial coating thin films of copper deposited on NaC1 monocrystalline planes fleshly cleaved. We have studied the influence of the temperature of the substrate during the evaporation of copper and the texture of the evapored layer for different thicknesses of the film.


This study is aimed at analyzing the effect of knowledge to detect errors and professional ethics toward consideration of materiality level as well as audit quality, to analyze consideration of materiality level as variable which mediate the effect of knowledge to detect errors and professionalal ethics toward the quality of audit. The study was conducted in Public Accountant Office in Sumatera. There are 108 questioner that have been given to the Public Accountant Office in Sumatera trough questionnaires. The data collecting method used is questionnaire which is sent by mail (mail survey) which is called primary data. Data quality is tested by validity and reliability test. Classic assumption tests used are normality, hetericedasticity, multicolinierity, and autocorrelation. Hypotesis test is done by path line and T-test. The Methods of data analysis in this study is use multiple linear regression with SPSS version 17.0. Validity and reliability test result show that knowledge to detect errors, professional ethics, consideration of materiality level and quality of audit are declare valid. Classic assumption test show all data regression used gas been passed from normality test, heterocedasticity, multicolinierity test and autocorrelation test. The result of path line analysis indicates that the knowledge to detect errors and professional ethics does not directly affect the quality of audit, but is mediated by the consideration of materiality level. Keywords: Knowledge, Ethics, Materiality, and Quality


The virus associated community-acquired pneumonia during seasonal influenza has a variety of appearances, and the clinical picture can range from asymptomatic infection to severe pneumonia with respiratory failure, acute respiratory distress syndrome, septic shock, multi-organ failure. Nowadays modern pulmonary support technologies are used to treat them, extracorporeal membrane oxygenation in particular. The article presents a clinical case of severe virusassociated bacterial pneumonia of a progressive course with severe respiratory failure (III) and developed pulmonary edema. The method of extracorporeal membrane oxygenation was used in the treatment, as there was a steady negative dynamic against the background of intensive therapy. The treatment algorithm from the patient's first call to a pulmonologist and transfer to an intensive care unit using extracorporeal membrane oxygenation is presented in the clinical case.


This paper begins by stating that adult education is facing two challenges. First, adult educators need to help people learn to live in harmony with the environment. Second, adult education must assist people in identifying ways to live peacefully with diversity. It is then argued that currently the field of adult education is characterized by a tension between those who subscribe to the professionalization of adult education and those who subscribe to radical adult education. This tension, it is argued, can be better understood as a shift in the structure of human consciousness. This perspective is then explored using as examples the agrarian and scientific/industrial revolutions as historical turning points in the evolution of new organizing structures of consciousness. This is then followed by an in‐depth discussion of the new emerging structure of consciousness and vision‐logic, and a brief discussion of the implications for adult education.


Column formed from a series of segments held together by an internal spring or cable can be coiled on a drum or extended into a rigid structure. This storable coil is useful in boring for soil samples and supporting electrical and optical sensors.


This research aims to (1) analyze the level of knowledge, attitudes, skills of horticultural farmers with the Aspakusa Makmur Association (2) analyze the success of the partnership pattern of horticultural farmers with the Aspakusa Makmur Association (3) analyzing the relationship of behavior of partner farmers with the success of partnership patterns in the Aspakusa Makmur Association The study was conducted in March-April 2019 at the Association of Aspakusa Makmur in Boyolali District. The method used in the research is survey. Data collection through interviews using a questionnaire. Sampling is done using the Complete Enumeration method by taking all members of the population as the study sample. All members of the Aspakusa Makmur Association farmer group numbered 35 respondents. Data were analyzed descriptively and quantitatively. The results showed that the level of knowledge of farmers in the Aspakusa Makmur Association was high, the level of attitudes of farmers in the Aspakusa Makmur Association was also high and the skill level of farmers in the Aspakusa Makmur Association was high, while farmers 'behavior had a positive relationship with farmers' knowledge and skills with success patterns unidirectional partnership.

Keywords: correlation analysis, knowledge, attitudes, skills, partnerships


The intention of the paper is to extend the testing methodology to a model of event structures with a dense time domain. Alternative characterizations of timed testing relations are provided. We also present algorithms for deciding timed testing for a subclass of the model under consideration. The key to our decision algorithms is that timed testing equivalences can be reduced to appropriate symbolic bisimulations.


The U.S. Army's Hardened Subminiature Telemetry and Sensor Systems (HSTSS) program has engaged the M/A-COM Corporation to work in the development of a highly accurate, crystal controlled telemetry transmitter chip set to be used in Army and other U.S. military munitions. A critical factor in this work is the operating environment of up to 100,000-g launch accelerations. To support the Army in this project, M/A-COM is developing integrated Voltage Controlled Oscillators (VCO) for L and S band, a silicon synthesizer/phase locked loop (PLL) IC, and a family of power amplifiers. Lastly, the transmitter module will be miniaturized and hardened using M/A-COM's latest chip-onboard mixed technology manufacturing capabilities. This new chip set will provide the telemetry engineer with unprecedented design flexibility. This paper will review the overall transmitter system design and provide an overview for each functional integrated circuit.


A method of CdTe solar cell structure of the laser scribing, the method comprising providing is operable to generate a laser light pulse. Characterized in that the light pulse temporal profile, temporal profile of the first power level during a first portion of the light pulses having less than during a second portion of the light pulse of the first power level a second power level. The method further comprises directing light pulses is irradiated on the CdTe solar cell structure. CdTe solar cell structure comprising: a substrate, a transmission spectrum adjacent to the substrate control layer, the control layer and the transmission spectrum adjacent to the barrier layer, the barrier layer and the adjacent conductive layers. The method further includes initiating a process of removing the conductive layer, and terminates the removal process prior to removing the insulating layer.


Thanks to the advancements in and convergent of the two technologies of horizontal well drilling and hydraulic fracturing, the oil production from tight formations has become possible and economic. While hydraulically fractured horizontals wells (HFHW) have increased the productivity of these reservoirs, these wells typically see a sharp decline in hydrocarbon rate due to tight nature of these reservoirs.
 Operators have improved oil recovery methods in these formations with the successful application of the secondary recovery method of waterflooding. This combination of HFHW and waterflooding has primarily been implemented in Canadian tight oil formations such as the Canadian Bakken Shale, lower Shaunavon, Viking, Belly River and Cardium. With the application of waterflooding on these HFHW, the one issue that operators are facing is the management of quick water breakthrough due to well to well communication through the network of induced or natural fractures resulting in poor sweep efficiency of waterfloods.
 Conformance improvement using polymer gel technology, a polymer and a polymer specific cross-linker, has been a common practice in conventional assets for 30 years. The polymer solution is mixed with the crosslinker on the surface and the mixture becomes more viscous (due to the reaction between polymer and crosslinker) as it is pumped downhole and into the reservoir. The application of polymer gel technology in unconventional tight oil water floods requires a new approach and is most successful when approached in a systematic way starting with proper diagnosis and candidate selection followed by engineering design and field execution. After candidate selection and diagnosis of communication between wells, a treatment design is put together based on the level of communication as measured by the transit time between the two wells. The conformance treatment is implemented by bull heading the mixture of polymer and crosslinker and sequentially increasing the gel strength by increasing polymer concentration at fixed polymer to crosslinker ratio. The idea is to build pressure continuously throughout the treatment, an indication of polymer gel filling up the path of communication.
 A new application for gel conformance technology, in tight oil waterfloods, as a cost-effective solution, to address the well to well communication and improve sweep efficiency is discussed in this article. Relatively smaller size and lower strength of gel, compared to the typical applications, makes the application of polymer gel in HFHWs unique and very effective. This paper will review multiple campaigns in Canadian Bakken from 2016 to 2018 and discuss the rate of success, incremental oil produced and longevity of these treatment. Opportunities to further optimize these treatments and the pitfalls have been recognized and discussed.


Solid phase (gel) separated from freshly prepared hydrogel having the batch molar composition: 2.5Na2O-8TPABr-60SiO2-800H2O as well as the solids drawn off the reaction mixture, during its hydrothermal treatment at 443 K and solid phase (gel) separated from freshly prepared hydrogel having the batch molar composition: 0.468Na2O×Al2O3×3.382SiO2×55.44H2O as well as the solids drawn off the reaction mixture, during its hydrothermal treatment at 353 K were analyzed by different methods such as powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning-electron microscopy (SEM), transmission electron microscopy (TEM), electron diffraction (ED) and atomic force microscopy (AFM). It has been found that the first mentioned freshly prepared gel represents a "hierarchical structure" in which the largest individual gel aggregates (having the size 200–1000 nm, or more) are composed of smaller particles having the size in the range 40–80 nm, which represent aggregates of 10 nm particles. The second gel is mainly composed of disc-shaped primary particles as well of partially or even fully crystalline entities. The nuclei formed inside both the gel particles and/or small nanocrystals formed by a limited grow of nuclei in the gel matrix, can grow only after their release from the gel dissolved during the crystallization, i.e. when they are in full contact with the liquid phase.


We consider the copula mapping, which maps a joint cumulative distribution function to the corresponding copula. Its Hadamard differentiablity was shown in van der Vaart and Wellner (1996), Fermanian et al. (2004) and (under less strict assumptions) in B\"ucher and Volgushev (2013). This differentiability result has proved to be a powerful tool to show weak convergence of empirical copula processes in various settings using the functional delta method. We state a generalization of the Hadamard differentiability results that simplifies the derivations of asymptotic expansions and weak convergence of empirical copula processes in the presence of covariates. The usefulness of this result is illustrated on several applications which include a multidimensional functional linear model, where the copula of the error vector describes the dependency between the components of the vector of observations, given the functional covariate.


Jozef Kozuchowski

Teaching of Ethics at Schools and the Safe Life, according to Robert Spaemann

The paper tackles the problem of whether Ethics should be taught at schools, following the great German philosopher, moralist, and pedagogue Robert Spaemann. His view coincides with the great classical tradition as personified in Socrates, Plato, Aristotle, St. Thomas Aquinas, and Kant. Some light is shed on what is essential for the teaching of Ethics for it to be appropriate and fruitful. Hence, several questions arise: the concept of Ethics, its objectives, its purport to be taught and handed on. These are connected with the problems to address: some erroneous theories, such as relativism, utilitarianism, consequentialism, hedonism, biological and sociological reductionism; the problem of how to realize the objectives and how to choose the convenient starting point for teaching. The pivotal importance of whether the Absolute exists is underscored. This importance – according to Spaemann, who follows here the great philosophical tradition – accounts definitely for rationality and loftiness of the moral order. Author's contribution consists (among other things) in the problem of the safety being outlined and demonstrated to be intrinsically and immediately connected with the teaching of Ethics, which, in turn, is enhanced as reasonable and valuable in the light of the safety-problem.

Keywords: classical philosophy, teaching of Ethics, life fulfilled, the safe life, Spaemann.


Abstract In his seminal 1989 study, Paul-Alain Beaulieu argued that Nabonidus was brought to power by a conspiracy orchestrated by Belshazzar and servants of Neriglissar and Lâbâši-Marduk, the usurper's predecessors on the throne. This paper offers a prosopographic investigation into Nabonidus's social network and reveals that, at the outset of his reign, the new king's entourage comprised other associates of Neriglissar and other potential conspirators.


In this notice, we correct imprecise statements in the article above [2]. In Proposition 1, we claimed that formulation (9) produces optimal solutions that are binary with respect to a, b, c and h for general convex function wtkðqtk,btkÞ: This statement is not precise. Proposition 1 holds for piecewise linear convex functions instead of general convex functions. This can be slightly revised to be a correct conclusion. In fact, constraint (8n) should be kept in the formulation when formulation (8) was reformulated to the formulation (9) by maintaining wtk as a decision variable, and thereafter the conclusion in Proposition 1 holds under piecewise linear convex functions. To that end, we make the following corrections:


The extraction kinetic behaviors of technetium in TcO4-/HNO3/TBP-kerosine,TcO -4 /HNO3-Zr/TBP-kerosine,TcO4-/HNO3-U/TBP-kerosine and TcO4-/HNO3-Zr-U/TBP-kerosine system were studied with a mini-sized Lewis cell.The extraction kinetic equations and apparent rate constants of TcO -4in these systems were calculated and the mechanism was discussed in this paper.In these systems,the rate of the extraction of Tc(Ⅶ) declines with the rise of temperature,and the apparent active energy is turned out to be minus value.


At present,we face the great presure of the inflation.The rising of husing prices is the main factor which causes the inflation.Housing price is closely relected to the consumer price index.The rising housing price directly affects wages and indirectly affects rent of land.The rising of land rent attects both land price and capital profits.The rising of housing price is a threat to financial safty and economic stability.


There are several prognostic scores for the assessment of risk of atrial fibrillation (AF) recurrence post ablation procedure. However, the use of these complex scores is difficult and the validation on different populations brought divergent results. Our goal was to compare the performance of these risk scores as the basis for the development of a new, simplified score based only on few universally predictive variables.


In this paper, the impedance perceived by an operator of a robot in multilateral control system under constant communication time delay is considered. The multilateral control system is one of the methods which transmit tactile sense to many remote places. Time delay possibly makes the performance of the multilateral control system worse. For example, time delay makes an operator feels large operational force. The operational force means that the operator feels the force except the reaction force from the environment. Moreover, time delay makes the operator feels that the environment is softer than the real stiffness. In this paper, the multilateral control system with three robots is considered. By frequency characteristics of the impedance perceived by the operator, the effect of time delay on the impedance perceived by the operator is verified. The results obtained in the analysis are verified by experimental results.


Iron-sulfur (Fe/S) cluster enzymes are crucial to life. Their assembly requires a suite of proteins, some of which are specific for particular subsets of Fe/S enzymes. One such protein is yeast Iba57p, which aconitase and certain radical S-adenosylmethionine enzymes require for activity. Iba57p homologs occur in all domains of life; they belong to the COG0354 protein family and are structurally similar to various folate-dependent enzymes. We therefore investigated the possible relationship between folates and Fe/S cluster enzymes using the Escherichia coli Iba57p homolog, YgfZ. NMR analysis confirmed that purified YgfZ showed stereoselective folate binding. Inactivating ygfZ reduced the activities of the Fe/S tRNA modification enzyme MiaB and certain other Fe/S enzymes, although not aconitase. When successive steps in folate biosynthesis were ablated, ∆folE (lacking pterins and folates) and ∆folP (lacking folates) mutants mimicked the ∆ygfZ mutant in having low MiaB activities, whereas ∆folE ∆thyA mutants supplemented with 5-formyltetrahydrofolate (lacking pterins and depleted in dihydrofolate) and ∆gcvP ∆glyA mutants (lacking one-carbon tetrahydrofolates) had intermediate MiaB activities. These data indicate that YgfZ requires a folate, most probably tetrahydrofolate. Importantly, the ∆ygfZ mutant was hypersensitive to oxidative stress and grew poorly on minimal media. COG0354 genes of bacterial, archaeal, fungal, protistan, animal, or plant origin complemented one or both of these growth phenotypes as well as the MiaB activity phenotype. Comparative genomic analysis indicated widespread functional associations between COG0354 proteins and Fe/S cluster metabolism. Thus COG0354 proteins have an ancient, conserved, folate-dependent function in the activity of certain Fe/S cluster enzymes.


A density functional for dynamical correlation, to be used in connection with wavefunctions of the complete-active-space self-consistent field type, is described, and first applications to the series of two- and four-electron atomic ions as well as to the H2 potential curve are given.


A new human tumor cell line, NCC‐c‐CX‐1 (CX‐1), was established from a uterine cervical cancer xenografted in nude mice. This cell line harbored approximately 50 to 100 copies of human papillomavirus (HPV) type 18 DNA per haploid genome, and contained about 16‐fold‐amplified c‐myc gene with rearrangement. These genomic alterations found in CX‐1 cells were also present in both primary tumor and xenografted tumor. Histopathologically, original and xenografted tumors were poorly differentiated cancer and were characterized by neuroendocrine features such as positive neuron‐specific enolase and chromogranin A by immunohistochemistry and abundant neurosecretory‐type granules in the cytoplasm by electron microscopy. However, the established cell line had lost the neuroendocrine features. This cervical cancer cell line may be a useful model for studying cervical carcinogenesis, especially the interaction between HPV and c‐myc oncogene.


INFECTIOUS lymphocytosis, originally thought to be a variant of infectious mononucleosis, was first described and named by Smith1 in 1941. Its chief characteristic is a benign, relative increase in...


Three studies using the Dreyfus model of skill acquisition were conducted over a period of 21 years. Nurses with a range of experience and reported skill-fulness were interviewed. Each study used nurses' narrative accounts of actual clinical situations. A subsample of participants were observed and interviewed at work. These studies extend the understanding of the Dreyfus model to complex, underdetermined, and fast-paced practices. The skill of involvement and the development of moral agency are linked with the development of expertise, and change as the practitioner becomes more skillful. Nurses who had some difficulty with understanding the ends of practice and difficulty with their skills of interpersonal and problem engagement did not progress to the level of expertise. Taken together, these studies demonstrate the usefulness of the Dreyfus model for understanding the learning needs and styles of learning at different levels of skill acquisition.


It is proposed a method for creating a drilling template (14 or 15) for a surgical implant in a jaw of a patient. A clinical user (dentist or dental technician) is given a transmission mask (10) to the hand with which he can make the time required for the surgical drill guide (14 or 15) itself. The method is intended for use in dentistry.


This study presents a method to evaluate the seismic risk of an extradosed bridge with seismic isolators of lead rubber bearings (LRBs), and also to show the effectiveness of the LRB isolators on the extradosed bridge, which is one of the relatively flexible and lightly damped structures in terms of seismic risk. Initially, the seismic vulnerability of a structure is evaluated, and then the seismic hazard of a specific site is rated using an earthquake data set and seismic hazard maps in Korea. Then, the seismic risk of the structure is assessed. The nonlinear seismic analyses are carried out to consider plastic deformation of bridge columns and the nonlinear characteristics of soil foundation. To describe the nonlinear behaviour of a column, the ductility demand is adopted, and the moment-curvature relation of a column is assumed to be bilinear hysteretic. The fragility curves are represented as a log-normal distribution function for column damage, movement of superstructure, and cable yielding. And the seismic hazard at a specific site is estimated using the available seismic hazard maps. The results show that in seismically-isolated extradosed bridges under earthquakes, the effectiveness of the isolators is much more noticeable in the columns than the cables and girders.


The formation of dendritic equiaxed grain structure by heated mold technique has been investigated experimentally and numerically. The mathematical model has been developed to simulate the convecti ...


Electro-optical combs generated from continuous-wave sources through amplitude and phase modulations have the potential to generate picosecond pulses with multi-GHz tunable repetition rates. They find applications in polarized Gamma ray production [1], imaging and picosecond acoustics. However, the development of such combs is mainly carried out with 1.5 μm laser sources [1, 2]. Only few developments exist so far in the Ytterbium gain window around 1 μm, where power scaling towards high average power and high energy is obvious. In this talk, we will report on the development of a picosecond (one) laser system operating at 1030 nm with a continuously tunable repetition rate between 11 and 18 GHz at the W-level average power.


The great expectation of the dairy owners from the frozen semen industry is quality semen with high fertility. Many researchers concentrate in this area to produce frozen semen of high quality and fertility. However, the problem still exists to minimize or reduce the cryoinjury related damages that occur during the process of cryopreservation with the use of all kinds of semen additives. The success rate of the additives added semen is variable at a larger scale. Therefore, any new molecules which can effectively prevent or minimize the cryoinjury are warranted and it could be low cost substances. Our incidental finding and protein identification with molecular weight ≈ 19 kDa (cold-inducible RNA-binding protein CIRBP) in goat spermatozoa seems to be effective in minimizing cryoinjury. The identified CIRBP was confirmed via Western blotting. In future, further studies are needed to confirm the molecular mechanism of the CIRBP on the cryoinjury as semen additives, and application of this protein added semen in the field to improve the level of conception rate in cattle.


Every engineering operation seeks to accomplish some practical result, which is measured by its financial worth or capacity to earn money by saving labor in doing something useful. There are no exceptions to this, but for railroad work, which will be the subject tonight, we often have to look further and deeper for the full measure of worth, than is usual in any other matters with which I am familiar.


The deep-mixing method can increase the strength of soft ground, and thereby improve the stability of earthen levees. Additional benefits are that deep-mixing support can accelerate construction and protect adjacent facilities from deformations that would otherwise be induced by the new embankment loads. Continuous shear walls located under the embankment side slopes and oriented perpendicular to the embankment centreline are more efficient for stability than isolated columns because shear walls are not subject to the same type of bending failure that isolated columns can experience. Even when continuous shear walls are used, stability analyses must consider multiple modes of failure, such as composite shearing, rotation of the deep-mixed zone, shearing on vertical planes along column overlaps, extrusion between shear walls, crushing of the deep-mixed ground at the toe of the deep-mixed zone and global instability. This paper presents simplified analysis methods for stability of earthen levees supported o...


The current authentication systems suffer from many weaknesses during the transmission of sensitive data across the clients. Textual passwords are commonly used. Users tend to choose meaningful words from dictionaries, which make textual passwords easy to break and vulnerable to dictionary or brute force attacks. Many available graphical passwords have a password space that is less than or equal to the textual password space. Many biometric authentications have been proposed. However, users tend to resist using biometrics because of their intrusiveness and the effect on their privacy. Moreover, biometrics cannot be revoked. In this system, multifactor authentication scheme is proposed. In the three dimensional virtual environment the authentication is given by interacting with the various objects and the user navigation is carried out through the objects. The sequence of actions and interactions towards the objects inside this environment constructs three dimensional passwords. The three dimensional password combines most existing authentication schemes such as Textual passwords, Graphical passwords, Biometrics to give more security for the sensitive data transactions. If all the three password matches, then the authorized user can transmit the data as well as receiver can receive the data. For the network security the data is encrypted before transmission. The receiver can decrypt the data and access the file. The proposed research work is implemented using VB.Net 2008 as front end and MS SQL Server 2005 as back end.


The crystalline structure and microstructure of some phases of the pseudo-binary system AlN–Al2O3 are discussed, with special attention to the γ spinel phase. Samples with AlN content ranging between 43.3 and 3.5 mol % were studied after different thermal treatments. X-ray and neutron diffraction Rietveld peak-profile refinement allowed the determination of the cell parameters and weight fraction of the phases. By checking different hypotheses of structure, it has been shown that the positions of the anions in the γ-AlON spinel phase are not ideal and correspond to a deformed face-centred cubic (f.c.c.) structure. This deviation is not due to the presence of vacancies in the cationic sublattice. The vacancies are distributed in the octahedral sites.


Objective:Explore the effective way to treat the idiopathic true precocious puberty(ICPP).Observe the effect of auricular point press therapy combined with nourishing YIN to lower pathogenic fire herb to the stature of ICPP girl.Methods:30 cases ICPP girl treating with auricular point press therapy combined with nourishing YIN to lower pathogenic fire herb,compared the change of stature before and after treating.Results:After treated,skeletal age difference/age difference(△BA/△CA)was fell from 1.34±0.63 to 0.65±0.32(P0.01),and the predicted stature was increased from 149.7±3.6 to 153.5±3.8(P0.01).Conclusion:The therapy of auricular point press therapy combined with nourishing YIN to lower pathogenic fire herb can obviously decrease the growth of skeletal,obstruct the maturation of skeletal,increase the predicted stature.


Resumen en: Water exchange between the Gulf of California and the Pacific has a significant vertical component. Surface (0-200 m) gulf water flows out into the Pacif...


Cloud computing is becoming an increasing popular technology where clients can subscribe for resources on a pay per use basis. Distributed Denial of Service (DDoS) is a common form of attack that targets cloud computing. Also, new features of cloud computing such as virtualization and virtual machine migration introduces additional challenges to cloud security as studies reports that the detection accuracy of anomaly detection system is degraded during the migration of virtual machine from one host to another. Therefore, providing effective security is paramount to the quality of service in cloud computing. DDoS attack is carried out by compromising vulnerable host which are used to carry out coordinated attack against a target. This paper therefore proposed a model for an adaptive and distributed IDS for cloud computing capable of effectively detecting coordinated attacks and also addressing challenges introduced by migration of virtual machines in cloud IDS.


Objective: To investigate the diagnostic value of collective determination of serum CA 19-9, CA-50 and CEA for pancreatic cancer. Methods: The levels of serum CA 19-9, CA-50 and CEA were determined in 27 patients with pancreatic cancer, 19 patients with liver cancer, 37 patient with gastroenteric cancer and 30 patients with benign gastroenteric disease by using microparticle enzymeimmunoassay and radio immunoassay, and the results obtained by both the assays were compared. Results: The levels of serum CA 19-9, CEA and CA-50 in malignant gastroenteric tumor group especially in pancreatic cancer group (P0 01) were significntly higher than that in benign gastroenteric disease group. Total positive of the three tumor markers or two of three markers higher than normal value or one of three markers twice higher than normal (CEA12ng/ml,CA 19-937 u/ml, CA-5020 u/ml) in pancreatic cancer group accounted for 88.89% (24/27), and showed statistically different (P0 005),if comparing these with single determination positive group (44 44%) and no statistical difference between liver cancer group and gastroenteric cancer group (P0 05),Conclusion:The collective determination of serum CA 19-9,CEA,CA-50 can be of great value for diagnosis of malignant gastroenteric tumor, especially for pancreatic cancer, and can therefore improve the correct diagnosis rate of pancreatic cancer.


12 In nature hydroxylapatite [Ca10(PO4)6(OH)2] is mostly present with various stoichiometric defects. 13 The most abundant is the carbonate ion that can occupy different crystallographic sites (namely A 14 and B types), however its effects on the apatite structure is still object of debate. 15 Type A carbonated apatite was quantum mechanically simulated in a previous study, here we 16 extend the simulation to bulk structural and vibrational features of Na-bearing type B and mixed 17 type A-B carbonated hydroxylapatite [Ca10-xNax(PO4)6-x(CO3)x+y(OH)2(1-y), space group P1]. The 18 simulation has been performed by ab initio density functional methods. The geometry of the models 19 (lattice parameters and internal coordinates) have been fully optimized exploring different positions 20 of the sodium ion in the apatite unit-cell. The results, in agreement with XRD data, suggest that in 21 each crystallographic cell in the biological mineral there is at least one calcium ion substitution or 22 vacancy per cell. The carbonate ion presence in the apatite structure is in good agreement with 23 biological/chemical data. Furthermore, there is also a very good agreement with FTIR data reported 24 in literature. 25 26