We show that equations of Newtonian hydrodynamics and gravity with Einstein's cosmological constant included admit gravitostatic wave solutions propagating in the background of Einstein's static Universe. In the zero pressure limit these waves exist at an average matter density exceeding that of Einstein's Universe. They have the form of a lattice of integrable density singularities localized at the maxima of the gravitational potential. These singularities are steady-state counterparts of the so-called Zeldovich pancakes (ZP), interim wall-like structures appearing at nonlinear stages of development of gravitational instability. As the average matter density decreases, the period of the ZP lattice increases diverging at the density of Einstein's Universe. Solitary wave solutions are found at exactly the density of Einstein's Universe, and at a slightly larger density the wave may be viewed as a lattice of well-separated ZP solitons.


PHARYNX AND NASOPHARYNX The Treatment of Peri-tonsillar Abscess. LEVINGER (Munich). {Archiv. fur. Laryngol., Band 34, Heft 1, p. 155.) The writer recommends at any stage his operation of extra-capsular enucleation of the upper pole of the tonsil under local anaesthesia (2 per cent, novocain with adrenalin), as described by him in 1914 (Munch. Med. Woch., No. 23) and in 1919 (ibid., No. 12). He postulates for the operation in the early stage with a thorough command of the technique. One advantage of this method of treatment is that it affords protection from recurrence. JAMES DUNDAS-GRANT. Clinical Reflexions on Peri-tonsillar Abscess. DR CANUYT, Strasbourg. (L'' Oto-Rhino-Laryngologie Internationale, January 1922.) The writer emphasises the following points regarding this condition. He quotes the case of the peri-tonsillar abscess left to mature. Suddenly the temperature and pulse rise, and the patient presents the classical signs of phlebitis of the cavernous sinus. The patient,


We discuss progressive Gelfand-Shilov spaces consisting of analytic signals with almost exponential decay in time and frequency variables. It is shown that such signals enjoy an additional localization property. We define wavelet transform and inverse wavelet transform in (progressive) Gelfand-Shilov spaces and study their continuity properties. It is shown that with a slightly faster decay in domain we may control the decay of the wavelet transform independently in each variable.


In the paper, it is given isomorphic classification of $F$-spaces of $log$-integrable measurable functions constructed using different measure spaces. At the same time, it is proved that such spaces are non-isometric.


This research is motivated by the use of smartphones that have not been optimized as a medium for learning physics. Students still have difficulty in mastering the concepts of temperature and heat. This study aims to: (1) determine the feasibility level of android-based physics learning media with the help of Smart Apps Creator on temperature and heat material to support student learning in the era of society 5.0, and (2) determine student responses to learning media. This study uses the R&D (Research and Development) method using a 4D development model, namely Define, Design, Development, Disseminate. The subjects of the research trial were material and media experts, teachers and students of class XI MIPA at SMA Muhammadiyah 7 Yogyakarta. Data collection instruments are questionnaires for material experts, media experts and student questionnaires. The method of analysis uses quantitative and qualitative analysis. The results of this study are as follows: (1) The feasibility level of android-based physics learning media assisted by Smart App Creator on temperature and heat material for class XI SMA based on the results of media experts obtained a score of 3.65 with a very decent category. The results of the material expert obtained a score of 3.72 with a very good category, so it was declared very feasible to use and could support student learning in the era of society 5.0. (2) The user's response to the learning media is getting a score of 3.57 with a very good category.


A low power and high-speed 24×24-b signed fixed point multiplier with modified booth encoder and wallace tree for FFT unit in DAB SOC is presented. An 18.81-ns multiplication time is achieved at 50 MHz, by optimizing modified signed extension algorithm, (k:2)compressors, connection algorithm and partition method of final adder. This multiplier has been verified in FPGA and implemented in chartered 0.35 micron CMOS standard cell technology, with its frequency being 50 MHz and its area 14 329.74 gates, power 24.69 mW. This architecture is compared with some other architectures using the same technology, and the result shows that it is effective and efficient.


The article is an analysis of the results of academic events held within the framework of the 6th St Petersburg International Labour Forum, held on March 14–18, 2022.The attention of the forum participants was focused on changes in the functioning of the labour market and new forms of employment in the post-pandemic period. The new socio-economic reality brought to life by the consequences of the COVID-19 pandemic, which are associated with the breakdown of traditional economic and social ties in conditions of isolation and migration restrictions, has significantly changed the sphere of work. This requires prompt decisions to restore employment, to introduce new forms of employment, to analyze the impact of modern types of work and the changed conditions of its implementation on labour relations and the quality of life of the population. To implement the solutions found, it is necessary to change legislation in various spheres of public life, change the ways of implementing management decisions and, in general, changes in state policy on the labour market and in the field of employment. Within the framework of the Forum, recommendations were developed on more than 50 sites for public authorities, businesses, educational organizations, and the scientific community on improving the functioning of the labour market and its adaptation to new postandemic conditions, including on improving labour legislation and legislation regulating economic activity, on improving law enforcement practice in this area, on accounting the impact of digitalization on various areas of public life, including to protect against interference by foreign companies in the digital sphere, under a reasonable restriction on the use of social networks for commercial purposes. Special attention was paid to informal employment and measures to control its expansion. Priority directions of scientific research in the field under consideration, as well as measures to improve the quality of management activities are proposed.


We present general relativistic magnetohydrodynamic simulations of merging equal-mass, spinning black holes embedded in an equatorial thin slab of magnetized gas. We evolve black holes either non-spinning, with spins aligned to the orbital angular momentum, and with misaligned spins. The rest-mass density of the gas slab follows a Gaussian profile symmetric relative to the equatorial plane and it is initially either stationary or with Keplerian rotational support. As part of our diagnostics, we follow the accretion of matter onto the black hole horizons and the Poynting luminosity. Throughout the inspiral phase, the configurations with non-zero spins display modulations in the mass accretion rate that are proportional to the orbital frequency and its multiples. Our frequency analysis suggests that these modulations are influenced by the initial geometry and angular momentum of the gas distribution. In contrast to binary models evolved in the gas cloud scenario, we do not observe a significant increase in the mass accretion rate after the merger in any of our simulations. This observation brings attention to a potential link between the electromagnetic signatures of massive binary black hole mergers and the geometrical distribution of the surrounding gas. It also suggests the possibility of not detecting a peak luminosity at the time of merger in future electromagnetic observations.


The present invention relates to a novel process for the preparation of substituted thiazol-2-ylmethylestern the general formula (II) via a multicomponent reaction. These compounds are mainly in the synthesis of tubulysins and Tubulysinderivaten of great interest.


Event studies are frequently used to estimate average treatment effects on the treated (ATT). In estimating the ATT, researchers commonly use fixed effects models that implicitly assume constant treatment effects across cohorts. We show that this is not an innocuous assumption. In fixed effect models where the sole regressor is treatment status, the OLS coefficient is a non-convex average of the heterogeneous cohort-specific ATTs. When regressors containing lags and leads of treatment are added, the OLS coefficient corresponding to a given lead or lag picks up spurious terms consisting of treatment effects from other periods. Therefore, estimates from these commonly used models are not causally interpretable. We propose alternative estimators that identify certain convex averages of the cohort-specific ATTs, hence allowing for causal interpretation even under heterogeneous treatment effects. To illustrate the empirical content of our results, we show that the fixed effects estimators and our proposed estimators differ substantially in an application to the economic consequences of hospitalization.


A time-domain code, SEALOADS, has been developed to predict ship motion, sea load and hydrodynamic pressure distribution of ship. The theoretical background of SEALOADS is outlined. Computations were carried out for a frigate in regular waves at various wave headings and steepnesses for different forward speeds. The predictions of heave, roll, pitch, shear force and bending moment, and pressures at several locations were presented. The validation study of computed results was carried out by comparing with experimental data from a hydroelastic model of the frigate.


For the purposes of estimating local changes in aquifer thermal regimes, induced by global climate change, we analyzed different performances of six general circulation models (GCMs) in the Sendai plain. Transfer function method was used to downscale the GCMs output to the local scale. GCM scenarios were evaluated based on their match with the 20 th century observations and the magnitude of climatic parameter change in 21 st century. Among the considered GCMs; HADCM3, MIROC and MRI models produced climate variations in a wide and consistent range (2.0 to 4.7 °C warming and -11 to 345 mm precipitation change) suggesting their applicability for climate change studies in the Sendai plain. When accounting the effects of the entire model scenarios, groundwater recharge would vary in range of 50-182 mm/year and aquifer temperature may change in 1.2-3.9 °C range in year 2080 which, according to IPCC AR4, may have critical impact on the ecological balance of the Sendai plain.


This paper examines the main issues regarding higher education in Korea—where college education experienced minimal interruptions—during the COVID-19 pandemic through a big data analysis of news articles. By analyzing policy responses from the government and colleges and examining prominent discourses on higher education, it provides a context for discussing the implications of COVID-19 on education policy and what the post-pandemic era would bring. To this end, we utilized BIgKinds, a big data research solution for news articles offered by the Korea Press Foundation, to select a total of 2636 media reports and conducted Topic Modelling based on LDA algorithms using NetMiner. The analyses are split into three distinct periods of COVID-19 spread in the country. Some notable topics from the first phase are remote class, tuition refund, returning Chinese international students, and normalization of college education. Preparations for the College Scholastic Ability Test (CSAT), contact and contactless classes, preparations for early admissions, and supporting job market candidates are extracted for the second phase. For the third phase, the extracted topics include CSAT and college-specific exams, quarantine on campus, social relations on campus, and support for job market candidates. The results confirmed widespread public attention to the relevant issues but also showed empirically that the measures taken by the government and college administrations to combat COVID-19 had limited visibility among media reports. It is important to note that timely and appropriate responses from the government and colleges have enabled continuation of higher education in some capacity during the pandemic. In addition to the media's role in reporting issues of public interest, there is also a need for continued research and discussion on higher education amid COVID-19 to help effect actual results from various policy efforts.


In order to achieve the whole staff-participated evaluation of operation of safety standardization in non-coal mines,an unascertained measurement model was built based on the uncertainty measurement theory.The index weights were calculated by the method of AHP.Indexs of supervision,guarantee,ability,performance were taken into account.Operation of safety standardization was classified into four grades which were A,B,C,D.A certain mine enterprise was taken as an example to evaluate.Unascertained measurements of individual indexes were obtained based on the marks given by 100 workers.Finally,the evaluation results of operation of safety standardization were obtained on the basis of the rule of incredible and index weights.The results show that the operation grade of the underground mine safety standardization is B,which agrees well with the evaluation results by the experts.


Viscous flow through macroscopic spherical cavities in a granular material is theoretically investigated. Number, size and configuration of the cavities are arbitrary, except that cavities are sufficiently distant to allow asymptotic analysis on their interaction, which is taken into account up to O(a/l)3 , where a and l are the characteristic radius and inter-cavity distance, respectively. Dependence of the flow field, flux into respective cavities and stress field etc on the cavity size, separation distance and orientation are analyzed. As further examples, 1D-, 2D-, and 3D-array of equal size cavities are examined, by which onset of the collapse of cavity and development of the collapsed region are elucidated. The latter may predict landslides and other flow-induced catastrophic changes in the material with quasi-equilibrium solid structure, as well as microscale waterway formation in human tissue known as angiogenesis.


SKEPTICS said that this was the bridge that couldn't be built. It was, and is, one of the costliest and longest of suspension bridges.


During the course of their careers, most facility management professionals hope that their responsibilities increase and eventually, they will be in charge of the facilities management function. If one is fortunate enough to have that happen, congratulations. This article outlines the issues one should address and the initial steps to take in one's first 60 days as head of facilities.


In scheduling, we are given a set of jobs, together with a number of machines and our goal is to decide for every job, when and on which machine(s) it should be scheduled in order to minimize some objective function. Different machine models, job characteristics and objective functions result in a multitude of scheduling problems and many of them are NP-hard, even for a fixed number of identical machines. However, using pseudo-polynomial or approximation algorithms, we can still hope to solve some of these problems efficiently. In this work, we give conditional running time lower bounds for a large number of scheduling problems, indicating the optimality of some classical algorithms. In particular, we show that the dynamic programming algorithm by Lawler and Moore is probably optimal for 1|| ∑ wjUj and P m||Cmax. Moreover, the FPTAS by Gens and Levner for 1|| ∑ wjUj and the algorithm by Lee and Uzsoy for P 2|| ∑ wjCj are probably optimal as well. There is still small room for improvement for the 1|Rej ≤ Q| ∑ wjUj algorithm by Zhang et al. and the algorithm for 1|| ∑ Tj by Lawler. We also give a lower bound for P 2|any|Cmax and improve the dynamic program by Du and Leung from O ( nP 2 ) to O (nP ) to match this lower bound. Here, P is the sum of all processing times. The same idea also improves the algorithm for P 3|any|Cmax by Du and Leung from O ( nP 5 ) to O ( nP 2 ) . The lower bounds in this work all either rely on the (Strong) Exponential Time Hypothesis or the (min, +)-conjecture. While our results suggest the optimality of some classical algorithms, they also motivate future research in cases where the best known algorithms do not quite match the lower bounds. 2012 ACM Subject Classification Theory of computation → Parameterized complexity and exact algorithms; Theory of computation → Design and analysis of algorithms


The concepts of Circular Economy (CE) and Solid Waste Management Program (SWMP) implementation are related to various qualities that may influence school stakeholders' participation in this program. This study investigated school stakeholders' awareness of Circular Economy (CE) concepts and the implementation of the Solid Waste Management Program (SWMP) in public schools. In order to uncover the relationship between these factors and relate stakeholders' experiences to their quantitative findings, convergent parallel mixed-methods research was used. The sample contained 370 respondents. The Awareness of Circular Economy Concepts Scaled Questionnaire (ACCESQ) and the Implementation of Solid Waste Management Program Scaled Questionnaire (ISWMPSQ) were modified for use as quantitative instruments, furthermore, for qualitative research, a validated interview guide was employed. For the quantitative analysis of the two factors, the weighted mean was utilized, and to identify the shape, direction, and strength of the relationship between the two variables, Pearson Product Moment Correlation, or Pearson "r" Coefficient was calculated. Moreover, the qualitative data was also analyzed using thematic analysis. Stakeholders' familiarity with Circular Economy (CE) ideas and the progress made on the Solid Waste Management Program were strongly correlated in every measure. Positive correlations were discovered between their encounters and the adoption of Circular Economy (CE) ideas and SWMPs. The results showed that climate change, biodiversity loss, waste, and pollution were all integral parts of sustainable waste management plans (SWMPs) for reusing, reducing, recycling, collecting, treating, and disposing of garbage. The more people understand CE principles, the more likely it is that the SWMP will be put into action, and the more closely the experiences of stakeholders will match the quantitative findings.


Relevance. Rabies is included in the group of transmissible viral zooanthroponoses that globally affect public health and the public economy. In Russian Federation, according to the State Standard 26075-2013, the method of virus isolation is a priority for the diagnosis of rabies, followed by detection by the method of fluorescent antibodies (MFA), however, the call of the World Health Organization to abandon research using animals makes it relevant to further develop and improve diagnostic methods in vitro.The purpose of the study. Designing a test system based on immunochromatographic analysis (IHA) for rapid diagnosis of rabies.Methods. Colloidal gold nanoparticles (CGN) with an optimal diameter (25–30 nm) were synthesized by citrate reduction of chloroauric acid and morphometrically characterized by the results of transmission electron microscopy. The conjugation of CGN with anti-rabies antibodies was carried out by non-covalent cross-linking, as a result of which stable conjugates were obtained with an immobilization coefficient of 91.8 ± 1.7%.Results. The classical scheme of direct (sandwich) was used IHA, in which the liquid phase (a sample containing the desired antigen) binds to labeled specific antibodies and, during migration through the solid phase, forms a colored complex with applied specific antibodies in the test zone («sandwich» NCHKZ-antibody — antigen — antibody). ICA was performed with positive, negative and heterologous antigens. The results of the study of samples by ICA were in direct correlation with the results of enzyme-linked immunosorbent assay (ELISA) and MFA and demonstrated 100% specificity. The presented data confirm the functionality of ICA for the detection of rabies virus antigen in pathological material.


Over 68,000 new cases of urinary bladder cancer are expected in the United States in 2008. Of these, an estimated 13,000 people will die of this disease. Urinary bladder cancer is the fourth most common new cancer in men and the ninth most common in women, with incidence rates of 30.0 and 7.1 per 100,000, respectively.1 Bladder cancer can be divided into two broad categories relating to the severity of disease. The first affects 70% of the patients and is characterized by low-grade tumors with frequent subsequent recurrence. Patients with low-grade malignancies have a good prognosis and low mortality rate. The remaining 30% of patients have high-grade tumor lesions. While both categories are associated with frequent recurrences, patients with high-grade lesions are at high risk for metastasis to other organs and tissues. Patients in this category have particular need for accurate diagnosis and staging in order to improve survival rates.2 The greatest utility for a bladder cancer-screening program is in high-risk populations, i.e., those who have previously had urological cancer. The relatively low incidence rate (44 patients per 100,000 population) makes a general screening program unlikely due to the risks and costs associated with cystoscopy and cytology, the current screening methods.3 However, screening individuals at high risk is beneficial for early bladder cancer detection. Thus, there is a real need for an accurate and non-invasive screening assay with high sensitivity and specificity to be used in these populations. Urine tumor markers are a promising area of oncologic medicine with the… ABBREVIATIONS: hTERT = human telomerase reverse transcriptase; hTR or hTERC = human telomerase RNA component; PCR = polymerase chain reaction; RUO = research use only; TRAP = telomeric repeat amplification protocol.


A 5-year-old boy suffered a stab wound to the back in the right paraspinal region that resulted in spinal cord injury at T2-T3 level and spinal shock.


The situation of the data holdings at the Secretariat improved in several areas during 2001, including the retrieval of important historical datasets from several countries, better estimation of the catches of fresh-tuna IUU vessels, progress in the sampling programmes in Thailand, Malaysia and Sri Lanka and the implementation of a sampling program in Indonesia under the scope of the IOTC-OFCF Project. On the contrary, there is still no information reported about the fleet of IUU deep-freezing longliners and the former-Soviet purse-seine vessels that continue to operate in the Indian Ocean. The situation of the data holdings for nominal catches and catch-and-effort data has improved considerably in the past year, although the scarcity of size-frequency data from the longline and artisanal fisheries continues to be a major impediment for the application of rigorous stock assessment.


The title of this thesis is "A Study on Present Status and Supporting Policy in connection with a Low Income Single Parent Family in Jeju region". It would be difficult at the present moment to predict exactly what problems may arise in the future. However, there should be efforts to find solutions for problems related to regulation of public order so that the risk of causing unreasonable consequences can be minimized. Since a Low Income Single Parent Support System is something that is being newly developed, a thorough examination of past problems can lead to a future a Low Income Single Parent Support System that is more rational and accords with substantial justice. Single parent family is the family that is consists of father or mother and children. But the single parent family support act also includes the family that is consisting of grandparents and grandchildren. Single parent family occurs from death of parent or divorce. Single parent family has some problems. First of all it does not have enough money for family support. Therefore single parent family support act was made in 2007. This research is targeted at a low income single parent family including a subsequent upper level who is under the protection of the system to guarantee a basic life of a nation in addition to the welfare system for mother and child as well as father and child and is not selected as a recipient in terms of standard for income asset, and duty of supporting one's family, etc. The purpose of this research is to find out the means for improvement by analyzing the system to guarantee a basic life of a nation in addition to the welfare system for mother and child as well as father and child and deriving relevant problems. I explained about the main contents of a Low Income Single Parent Support System and dealt with the important contents of a Low Income Single Parent Support System and suggested especially the problems and improvements of current Ordinance in connection with a Low Income Single Parent Support System in Jeju region.


An algorithm for tracking the degree of quaternion impropriety in real-time is proposed. This is achieved by exploiting the i-, j-, and k-pseudo-covariances, which makes it possible to introduce an impropriety measure as the minimum mean square error (MMSE) solution for estimating the quaternion involutions along the i, j, and k axes from the quaternion random variable itself. For rigour, convergence conditions for both the mean and mean square behavior of such a real-time impropriety tracker are established, and the effect of the degree of impropriety on the steady-state performance of the algorithm is analyzed. The concept is supported by simulations on both synthetic data and on real-world wind data recordings.


The characteristics of commercial pedestrian street are large fire load,personnel intensive and difficult evacuation.Fire safety measures have been put forward from the perspective of design with the example of a commercial plaza.Using the sub-safety design concept,the fire smoke in the fire unit is controlled in the unit by mechanical exhaust system and automatic sprinkler system.Ten scissors stairs are set up along the pedestrian street to evacuate.Bottled combustible gas and fuel liquid is strictly prohibited in restaurant operating room.Mechanical exhaust system should be set in commercial buildings on both sides of the street.


In order to continuous the advancement of technology, the development of Internet of Things technology will greatly promote the intelligent, we make information and automation of buildings, which is of great significance for promoting intelligent buildings. The modern intelligent building electrical energy-saving design measures can not only realize the energy-saving design, the real purpose is to save energy and reduce emissions, promote energy-saving emission reduction can promote China's sustainable development, implement scientific methods, and assist China's economic development. When designing, we designers should consider various factors and rationally design electrical energy-saving measures.


OBJECTIVE To analyze the cost performance of small packs of surgical instruments and to look for their optimizing sterilization schemes.METHODS 720 sample from total surgical instruments were sefested,pressuresteam sterilization ethylene Oxide and hydrogen peroxide plasma sferilization were pexformal and compared.Statistics and analyzing finally under the condition of each kind puts The sterilization effect,cost and the period were analyzed.RESULTS All three methods call guarantee the sterilization effect,but the cost of EO and plasma were more than those of pressuresteam method(452% and 960%).CONCLUSIONS Pressuresteam sterilization show advantages in small packing instruments.


Time-triggered automotive networks use time-triggered protocols (FlexRay, TTEthernet, etc.) for periodic message transmissions that often originate from safety and time-critical applications. One of the major challenges with time-triggered transmissions is jitter, which is the unpredictable delay-induced deviation from the actual periodicity of a message. Failure to account for jitter can be catastrophic in time-sensitive systems, such as automotive platforms. In this article, we propose a novel scheduling framework (JAMS-SG) that satisfies timing constraints during message delivery for both jitter-affected time-triggered messages and high-priority event-triggered messages in automotive networks. At design time, JAMS-SG performs jitter-aware frame packing (packing of multiple signals from Electronic Control Units (ECUs) into messages) and schedules synthesis with a hybrid heuristic. At runtime, a Multi-Level Feedback Queue (MLFQ) handles jitter-affected time-triggered messages and high-priority event-triggered messages that are scheduled using a runtime scheduler. Our simulation results, based on messages and network traffic data from a real vehicle, indicate that JAMS-SG is highly scalable and outperforms the best-known prior work in the area in the presence of jitter.


Interest in otters seems to be increasing in Finland. In order to get a general view of recent studies, I asked certain authors for information about their projects. Distribution surveys have been done. Caesium levels (following Chernobyl) have been assayed. Threats, captive breeding and reintroductions are reported.


This research aims to discover validate the endosymbiotic theory of chloroplast by comparing chloroplast DNA and cyanobacterial DNA using computational methods such as apriori and decision tree. We compared the nucleotide sequences of four plants that each represent four evolutionary classes, bryophytes, pterophyts, gymnosperms, and angiosperms, and Synechococcus DNA. The rules extracted from five experiment object commonly shown abundance in involution of aminoacid leucine and serine. 4 to 11 rules were shared between each chloroplast DNA and the Synechococcus DNA, supporting endosymbiotic theory. Also, the rules extracted from decision tree shown similar patterns, implicating the similar evolutionary steps of the chloroplast from cyanobacteria for different classifications.


Polycyclic Aromatic Hydrocarbons (PAHs) are byproducts of incomplete combustion of organic materials during industrial and anthropogenic activities and their toxicity has been established. The objective of this investigation was to determine the depth-wise distribution and profile characteristics of 16 priority PAHs which is lacking in the study area. After extraction and purification quantification of PAHs was done using GC-FID with strict adherence to standard quality control/assurance measures. Results of descriptive statistics showed that the obtained concentrations of PAHs in most sample points are log-normal. Also, results revealed the concentration (%) of PAHs in top-sample D, E and F varied from 0.18 (Flu) – 20.25% (B[ghi]p), 0.78 (Ace) – 18% (I[123-cd]p) and 2.06 (B[k]f)/(B[b]f) – 18.02% (Phe) respectively. While in sub-profile sample D, E and F ranges from 0.37(Flu) – 41% (B[ghi]p), 0.73 (Flu) – 20.02% (B[ghi]p) and 0.61(Flu) 23.04% (B[ghi]p) respectively. Percentage distribution of PAHs profile showed the prevalence of LPAHs in top-samples over HPAHs and HPAHs over LPAHs in sub-samples. Agglomerative dendogram of top and sub-samples showed that most PAHs homogeneity were built along molecular structure were LPAHs dominated the first and second cluster groups, while third and fourth cluster groups having HPAHs. The obtained PAHs values in this study could help to set a baseline concentration benchmark and evaluation of exposure risk to terrestrial and aquatic ecosystem in the rapidly urbanizing area since recorded mean concentrations are above permissible limits for soil use.


It took various factors including train class,delay status and remained distance into account to analyze the possible rescheduling strategies in train operation of passenger dedicated line under the operation mode with both high-speed and middle-speed trains.On this basis,the process of train rescheduling was simulated according to the behavior of dispatchers under various situations that different types of delay occurred and different strategies were applied.The analysis results of quantity of delayed trains and delay time showed that: 1) The high-speed trains had greater anti-turbulence ability.The better result could be achieved if all trains ran by the existing order.2) If the middle-speed trains were prohibited to influence the high-speed trains,they would have poor anti-turbulence ability and the trains with longer remained distance and the punctual trains should have greater priority.On the contrary,their anti-turbulence ability would increase remarkably.At the same time,the influence on high-speed trains would be quit little if only the time that high-speed trains could be postponed was less than headway time between them.


ObjectiveTo examine the effects of different community intervention model for the cognitive of demented patients in community.MethodsThe sample was composed of 222 patients with dementia or mild cognitive impairment. They were divided into 3 groups: the control group (n=177) received no special intervention, while the psychosocial interventions group (n=29) received psychosocial intervention alone, and the integrated group (n=16) received both psychosocial intervention and pharmaceutical intervention. Cognitive level of the patients was assessed at baseline, the end of the 3rd and 6th month.ResultsCompared with baseline, the integrated group showed a significant increment in the scores of MMSE and DS(difference:MMSE:-2.800± 2.111 ,P0.001;DS:-2.077±2.565,P0.05).For the control group, some expected results were found, including a significant decrease in the scores of MMSE and BD(difference:MMSE:0.788±2.587,P0.01;BD: 0.642 ±2.670, P0.05).Compared with the psychosocial interventions group and the control group, the integrated group also presented with interesting results, the differences of MMSE was negative, which implied a increase in their scores of MMSE(mean difference=-3.050,P0.001;mean difference=-3.598,P0.001,respectively).ConclusionIn the community support system, the cognitive level of patients in the control group deteriorated gradually, the effects of the psychosocial interventions group were acceptable, while the effectiveness of the integrated group was better than that of the psychosocial interventions group.


"Taiping Jing" is one of the classics of Taoism at early stage, containing a wealth of longevity thoughts, mainly including keeping "One" for longevity, kindness and longevity, medicine nursing and refraining for health and other aspects. These ideas play a positive role in enlightening the Taoists and the public at that time and thereafter, which are worthy of our


We present a comparison of Fisher matrix forecasts for cosmological probes with Monte Carlo Markov Chain (MCMC) posterior likelihood estimation methods. We analyse the performance of future Dark Energy Task Force (DETF) stage-III and stage-IV dark-energy surveys using supernovae, baryon acoustic oscillations and weak lensing as probes. We concentrate in particular on the dark-energy equation of state parameters w0 and wa. For purely geometrical probes, and especially when marginalising over wa, we find considerable disagreement between the two methods, since in this case the Fisher matrix can not reproduce the highly non-elliptical shape of the likelihood function. More quantitatively, the Fisher method underestimates the marginalized errors for purely geometrical probes between 30%-70%. For cases including structure formation such as weak lensing, we find that the posterior probability contours from the Fisher matrix estimation are in good agreement with the MCMC contours and the forecasted errors only changing on the 5% level. We then explore non-linear transformations resulting in physically-motivated parameters and investigate whether these parameterisations exhibit a Gaussian behaviour. We conclude that for the purely geometrical probes and, more generally, in cases where it is not known whether the likelihood is close to Gaussian, the Fisher matrix is not the appropriate tool to produce reliable forecasts.


Abstract of a study published by the "Population and Family Planning Board", Research Office, sponsored by the Supreme Council for Population and Family Planning in Egypt, July 1981.


They're On Our Side : The United States and Right-wing Dictatorships, 1921–1965. Finally, the secondary sources are extraordinarily dated. For a book published in 2007, the latest work cited in the bibliography is from 1995, one of perhaps half a dozen sources from the 1990s. Thus, fascinating studies such as Frederick Pike's 1995 work, FDR's Good Neighbor Policy : Sixty Years of Generally Gentle Chaos are nowhere to be found. Of more concern is the narrowness of the primary research. Despite the fact that Franklin Roosevelt figures prominently in the book's title, no work was undertaken at the Roosevelt Presidential Library. The papers of Cordell Hull in the Library of Congress are also untouched. And although the decimal files for Nicaragua are scoured with some enthusiasm, other collections such as the Records of the Office of American Republic Affairs, 1918–47, Records of the Deputy Assistant Secretaries of State for Inter-American Affairs, and other rich sources in Record Group 59 are ignored. The complete lack of sources from the Nicaraguan side is also troubling, since much of Crawley's thesis rests on the notion that Nicaraguan politicians and parties were highly influenced by the United States' action (or inaction). Andrew Crawley has produced a fairly well written book with some interesting ideas. The serious gaps in both the primary and secondary research undertaken by the author, however, seriously compromise the main thesis and reduce the monograph's overall contributions to the field.


We construct a strongly local regular Dirichlet form on the golden ratio Sierpinski gasket, which is a self-similar set without a finitely ramified cell structure, via a study on the trace of an electrical network on an infinite graph. The Dirichlet form is the unique one that is self-similar in the sense of an infinite iterated function system, and is decimation invariant with respect to a graph-directed construction. The proof is based on a fixed point problem of a renormalization map, inspired by Sabot's celebrated work for finitely ramified fractals. Lastly, the Hunt process associated with the Dirichlet form satisfies a two-sided sub-Gaussian heat kernel estimate.


Using molecular dynamics simulations, we investigated the reusable performance of the nanofluidic energy absorption system (NEAS) to dissipate the impact energy created by a drop hammer (simulated by a carbon plate with an initial velocity and mass). The effects of nanopore flexibility and surface roughness on the reusable performance of NEAS are also considered. The results clearly shown that NEAS can only convert the mechanical energy into the solid–liquid interfacial energy (i.e., store it in the system) in the loading stage; the stored interfacial energy is gradually released and finally dissipated as heat by the solid–liquid interaction in the unloading stage. Therefore, the unloading response of NEAS decides whether or not the system can be reused for energy absorption, which is sensitive to the loading condition. Although NEAS behaves as a one-time used energy absorption material under quasi-static loading condition, it can be reused under dynamic loading condition. In addition, the nanopore surfac...


The project is funded from Norway Grants in the Polish-Norwegian Research Programme, operated by the National Centre for Research and Development


The extensive use of sensors and communication devices in smart grid has greatly increased the quantity of surge protection devices (SPDs). Meanwhile, it puts forward higher requirements for the informatization level of monitoring and maintenance of SPDs. In order to realize the intelligent management of SPDs, the SPDs real-time monitoring system for the smart grid is developed. Specifically, the STM32 microcontroller is used in this system to collect the working state and environmental information of SPDs. In addition, occurrence time, number of lightning strikes and the peak value of lightning current can also be automatically measured and recorded. In particular, the maximum measurable lightning current of the system is 100 kA. What's more, the sampling rate of the system is 1MHz and the data storage capacity is 1MB. Besides, these data are uploaded through three communication methods include RS-232, 2.4G and GPRS. The system has realized the online running state tracking of SPDs and estimate of the deterioration situation and the precise location of the deterioration module. The results of this study laid a foundation for the SPDs lifetime assessment, highly efficient maintenance and differentiated lightning protection design.


We propose secure protocols for user authenticated quantum key distribution on jammable public channels between two parties, Alice and Bob. Via an arbitrator, Trent, these protocols provide data i ...


Moen targets a view about the intrinsic harmfulness of prostitution that he sees as widespread in healthcare, academia and public policy.1 He argues that the exchange of sex for money is not intrinsically harmful by systematically rejecting various possible proposed harms. He further suggests that it is the social context of discriminating laws and stigma that accounts for the harms experienced by prostitutes, rather than any intrinsic feature of exchanging sex for money.

One striking aspect of his argument is the particular way in which he characterises the common view about the harmfulness of prostitution. Consider the following two possible versions of the claim that prostitution is harmful: The intrinsic claim: The exchange of sex for money is intrinsically harmful to the seller. The contingent claim: Prostitutes are currently likely to experience significant harm.

The intrinsic claim is …


Imagination is often giving expression to the needs, aspirations and problems of individuals. However, when articulated and disseminated, they may sometime crystalize similar views of others, and even influence them. The imaginary status of these mental constructs nonetheless becomes part and parcel of the factual world, or sometimes of what may be called history. Oftentimes, they are more powerful than many historical facts. Though belonging to the realm of the imaginaire a certain consistency is achieved by the act of committing to writing on the one hand, and by some inner logic characteristic of the imaginaire. When adopted into wider literary bodies, the structure of the imaginaire is impacted by problems of the larger, and often times more ordered, type of literature. This is what happened to the ancient imaginaire of artificial anthropoid: though it had appeared in the Talmudic literature which is rather non-constellated, it has been subsequently embedded into more articulated structures, adapting thus additional meanings.' The following discussions strive to illustrate the use of views regarding the Golem within the framework of two different trends in Jewish religious thought. On the one hand the propensity to imitate God, including the attempt to create anthropoids as part of this propensity and, on the other hand, the tension that emerges from such an attempt: its success may imply a potential usurpation of the unique status of God as the single creator of man. The later, emerging since early Middle Ages apparently under the impact of an external source found in Arabic, has been sometimes rejected by Jewish mystics and I shall pay special attention in the following sections to this topic. Thus, any understanding


We demonstrate that even in the classical experimental situation of a linear model the performance of the experiment can be improved by applying the concept of adaptive designs.


Abstract : This report summarizes the method and documents the results of cadet designs at the United States Military Academy during Spring Term, 1993. The focus of these designs was the analysis of a futuristic system: The Future Main Battle Tank (FMBT). All the cadets declared Systems Engineering as their major area of study. Our purpose was academic: to provide the cadets with a real Army design problem which would serve as a capstone exercise, drawing on the wide base of the knowledge gained during their four year curricula.


A Bragg grating reflector was fabricated through the coating with a centre wavelength of 1544.5 nm, and a peak reflectivity of 100%. Breaking strength of this grating was 61.05 N (4.97 GPa) at a rate of 1% strain/min. The change in the modulus of the coating layer was within 20%.


The node deployment optimization techniques is the main point of application of wireless sensor networks,is the hot issues of domestic and foreign scholars in recent years in the military,civil defense,environmental and other fields has broad application prospects.For wireless sensor node deployment methods exist uneven distribution of nodes,covering the incomplete wait,proposed a cloud model to improve particle swarm optimization for wireless sensor node deployment.The experimental results show that this method can be completed relatively small cost sensor aware node deployment,fast convergence in the optimal solution can reduce network deployment costs,and improve overall network coverage.


The process of the analysis and design of a testing process management platform for medium and small domain software corporations is expounded.Based on web technique, the platform uses B/ S structure and is used on Intranet/Intertnet.The paltform aims at testing plan and risk management, testing judgment and defects tracking, customers feedback and testing summary.A flow of testing process is proposed.A series of functions, such as system registering, system, configuration management, testing plan management, testing case management, testing log management, testing report management, testing summary management and testing document management are implemented.


The ability of dying cancer cells to induce an anticancer immune response can increase the effectiveness of anticancer therapies, and such type of death is termed immunogenic cell death (ICD). Cells can die along the ICD pathway when exposed not only to chemo- and immunotherapeutics, but also to various types of radiation, such as ionizing radiation and cold atmospheric plasma jets (CAP). We have previously shown that CAP, lactaptin, and a recombinant vaccinia virus encoding lactaptin induce in vitro molecular changes typical of ICD in cancer cells. In the current work, we treated MX-7 rhabdomyosarcoma cells with CAP and lactaptin-based anticancer drugs and evaluated the immunological effects of the treated cells. We showed that dendritic cells (DCs) captured cells treated with various ICD inducers with different efficiency. CAP-treated cells were weakly potent in inducing the maturation of DCs according to MHC II externalization. Moreover, CAP-treated cells were worse in the stimulation of IFN-α release in vitro and were poorly captured by spleen DCs in vivo. Under the irradiation conditions used, CAP was not capable of activating a significant immunological anti-tumor effect in vivo. It is possible that modifications of the CAP irradiation regimen will enhance the activation of the immune system.


- The invention relates to a device for measuring the Doppler effect, the changing diameter of a veine.- According to the invention, the device is operable. when generating a first signal, controlling a transmitting and receiving probe (3) in a continuous mode, so as to obtain a function of the position of the transmitting and receiving probe with respect to the vein , an audible signal on a loudspeaker adapted to locate the vein ,. and upon generation of a second signal which occurs after the location of the vein, controlling the transmitting and receiving probe (3) in a batch mode and determining from variations in frequency between the ultrasound waves emitted and received, the diameter of the vein to ensure the display of the change.


Immigrants dominated the Communist Party of the United States (CPUSA) during long periods of its existence.1 Despite this, relatively little has been written concerning the activities of the score of organized foreign language or national groups within the CPUSA.2 Whether due to lack of access to resources or language barriers, the failure to study the activities of these groups leaves a hole in the understanding of the activities of the CPUSA.


The advance of information and communication technology has brought some changes to the society. Unfortunately, in Indonesia, it carries with its consequences, such as digital literacy. Based on the studies of the field, women's involvement is lower compared to that of men. The divide in digital literacy is due to several factors; those are geographic factor, skills and education, government policy, as well as economic and cultural systems. The urgency has signified the need to empower Indonesian women in using technology through digital literacy. It is expected that women will not only gain information, but also improve their quality of life. The efforts were taken through increasing Indonesian women's capacity through five competences: access, analyze and evaluate, create, reflect, and act.


Compared the ecological conditions of Liangshan and Mao county with those of original country,it shows that Lianshan is basically and Mao county is completely fit for Angora goat,which are experimental areas of Angora goat.According to the biological characteristics,nutrient needs and the internal and external experience of feeding and management of Angora goat,the actual circumstances of experimental areas as well,we make and carry out the modle "putting pasture first,and combining supplementary feeding",the management program of pasture and feeding,the classifications and amount of supplementary feed,protetive inoculation and using vermifuge regularly,offering suitable goatfold and equipment.These feeding and management techniques ensureus to improve the performence of Angora goat and hybrid generations.


Ultrashort high harmonic extreme-ultraviolet pulses are applied for taking snapshots of the relaxation of atomic inner-shell vacancies. A novel gating mechanism utilizes the momentum exchange between electron wave packets and a laser field.


A 10-year-old girl with low birthweight dwarfism, slow growth and mental development, peculiar facies, bilateral cataract, mental retardation, and the radiographic changes of metaphyseal and epiphyseal bone dysplasia is described. We suggest that this case may represent a new, hitherto undescribed, syndrome.


The Multiple Knapsack Assignment Problem (MKAP) is an interesting generalization of the Multiple Knapsack Problem which has logistical applications in transportation and shipping. In addition to trying to insert items into knapsacks in order to maximize the profit of the items in the knapsacks, the MKAP partitions the items into classes and only items from the same class can be inserted into a knapsack. In the literature, the Gurobi integer programming software has solved MKAPs with up to 1240 variables and 120 constraints in at most 20 minutes on a standard PC. In this article, using a standard PC and iteratively loosening the acceptable tolerance gap for 180 MKAPs with up to 20,100 variables and 1,120 constraints, we show that Gurobi can, on average, generate solutions that are guaranteed to be at most 0.17% from the optimums in 43 seconds. However, for very large MKAPs (over a million variables), Gurobi's performance can be significantly improved when an initial feasible solution is provided. Specifically, using from the literature, a heuristic and 42 MKAP instances with over 6 million variables and nearly 90,000 constraints, Gurobi generated solutions guaranteed to be, on average, within 0.21% of the optimums in 10 minutes. This is a 99% reduction in the final solution bound (gap between the best Gurobi solution and the best upper bound) compared to the approach without initial solution inputs. Hence, a major objective of this article is to demonstrate for what size MKAP instances providing Gurobi with an initial heuristic solution significantly improves performance in terms of both execution time and solution quality.


The objective of this paper is to detect and recognize the characters in the signage's (traffic place name board). It is applicable especially for Indian conditions. It detect the green colored signage's from the background using seamearing algorithm and extract the detected signage's board then convert it into binary image. Next, it detect the signage characters from signage's using horizontal segmentation and vertical segmentation algorithms, it extract each individual character from the signage's. Then, the features are extracted from individual character of signage's using DCT, DWT and Hybrid DWT-DCT. In training phase, 324 discrete wavelet features are extracted from 36 characters(9 features extracted from 36 character) in DWT, 20 highest energy coefficients are extracted by using DCT and 20 highest energy coefficients are extracted using Hybrid DWT-DCT. Finally, the extracted features from each characters are recognized using SVM. Selection of feature is probably important factor to achieve high performance in recognition. The application of this paper is a driver assistant system, to guide the driver while driving , traffic safety by calling the driver's attention to the presence of key traffic information board. The performance of signage recognition is evaluated for place board image and the system achieves a recognition rate of 94.44% using DWT , 91.66 % using DCT, 97.22% using Hybrid DWT-DCT and SVM.


ABSTRACT: One of the main diseases affecting yam crops (Dioscorea spp.) in Brazil is the dry rot caused by Scutellonema bradys, Pratylenchus brachyurus and P. coffeae nematodes. The use of biological control agents is an auspicious procedure which has been tested in order to reduce losses by pathogens. The objective of this work was to evaluate the nematicidal activity in vitro and in vivo of commercial biological products on yam dry rot nematodes. Products based on Trichoderma harzianum (2.0 x 109 conidia mL-1) at dosages of 1.5 and 2.0 L 200 L-1 of water; Bacillus subtilis 20% - 1.0 x 1011 cfu g-1 + B. licheniformis 20% - 1.0 x 1011 cfu g-1 at 100 and 150 g 100 L-1; B. subtilis 200 g kg-1 + B. licheniformis 200 g kg-1 at 130 and 200 g 100 L-1; combination of rhizobacteria including Bacillus spp. and organic carbon at 5L and 7L 100 L-1; and the control (distilled water), were tested in in vitro assays on S. bradys or Pratylenchus sp. In experiments performed under greenhouse conditions, healthy seed tubers were planted in sterilized soil and thirty days later the soil was infested with a suspension of 1,000 specimens of a mixed population of S. bradys and P. coffeae. Then, after 30 days products based on B. subtilis 20% + B. licheniformis 20% - 150 g 100 L-1; T. harzianum 2 L 200 L-1 and rhizobacteria + organic carbon 7 L 100 L-1, at 100 mL per pot, were applied to the soil. Three months after planting, the percentage of sprouting of the seed tubers was evaluated and in the fifth month, the nematode population densities were determined. The sprouting of seed tubers was of 100% in all treatments. Bacillus subtilis 20% + B. licheniformis 20% and T. harzianum caused 89% and 61% mortality in S. bradys respectively, at the highest concentrations. In specimens of Pratylenchus sp., rhizobacteria + organic carbon exhibited 51% and 45% mortality at higher and lower concentrations, respectively. Under greenhouse conditions, B. subtilis 20% + B. licheniformis 20% and rhizobacteria + organic carbon were more effective in reducing nematode population densities, compared to the control.
KEYWORDS: Dioscorea spp.; Scutellonema bradys; Pratylenchus sp.


We present optical and ultraviolet (UV) observations of a luminous type Ia supernova (SN Ia) SN 2015bq characterized by early flux excess. This SN reaches a B-band absolute magnitude at M B = −19.68 ± 0.41 mag and a peak bolometric luminosity at L = (1.75 ± 0.37) × 1043 erg s−1, with a relatively small post-maximum decline rate [Δm 15(B) = 0.82 ± 0.05 mag]. The flux excess observed in the light curves of SN 2015bq a few days after the explosion, especially seen in the UV bands, might be due to the radioactive decay of 56Ni mixed into the surface. The radiation from the decay of the surface 56Ni heats the outer layer of this SN. It produces blue U − B color followed by monotonically reddening in the early phase, dominated iron-group lines, and weak intermediate-mass element absorption features in the early spectra. The scenario of enhanced 56Ni in the surface is consistent with a large amount of 56Ni ( M56Ni=0.97±0.20 M ☉) synthesized during the explosion. The properties of SN 2015bq are found to locate between SN 1991T and SN 1999aa, suggesting the latter two subclasses of SNe Ia may have a common origin.


In evaluating injury in children, child protection paediatricians are tasked with determining whether the history given by parents or caregivers is valid with respect to explaining injury causation. This paper summarises metacognition and in particular the dual processing theory of 'fast and slow thinking' to explain how complex information in contexts of uncertainty is processed to produce decisions and responses, applied to a child protection context. An example is used that resembles abusive head trauma which focuses on understanding the difference between likelihood and plausibility in forensic interpretations of injury causation.


We show in this paper that many of the difficulties, encountered in using the ferromagnetic MnSb films as storage media in memory devices employing the technique of laser Curie point writing and magneto‐optic readout, can be overcome by forming solid solutions of MnSb with Fe, Co, In, and excess Mn, viz. Mn1−xFexSb, Mn1−xCoxSb, MnSb1−xInx and Mn1+xSb (0≤x≤0.25 or 0.3). Spins that are in basal plane of MnSb at 300 K are found to reorient to be along the film normal, from ferromagnetic resonance work, beyond a critical composition (xc=0.16, 0.21, 0.16, and 0.14 for the systems containing Co, Fe, In, and excess Mn, respectively) ensuring a large readout efficiency. Moreover, the lowering of Curie temperature for higher compositions can enable us to work with low power lasers which help to achieve sharper writing without diffusion of heat into neighboring domains. In addition, the absence of any crystallographic phase transformation in the temperature range of operation (unlike in MnBi) makes the MnSb alloys ...


This study focuses on developing a scale that encompasses aspects of readiness to change by library management in dealing with the next normal in libraries. It investigates measuring change readiness in terms of library service operations, workflows, administration, programs, and spaces, which can give an overall view of a library institution's preparedness to meet new roles and expectations. While there were several readiness-for-change instruments constructed for various organizations and institutions, this study uses a two-phase approach, attempting to design an instrument and validate the items in this scale. The scale, referred to as Change-Readiness Instrument for Library Managers (CRILM), was derived from an original self-developed questionnaire and consists of a 20-item readiness-for-change attributes. CRILM was subjected to a verification process for its applicability, relevance, and clarity of the items. The Kaiser-MeyerOlkin (KMO) measure of Sampling Adequacy and Bartlett's Test of Sphericity were conducted to validate the adequacy of data. The items were factor-analyzed to see the correlations using the Principal Component method of extraction with Varimax Rotation. Cronbach's Alpha was employed to calculate reliability and verify the items' consistencies of scale. Library managers who are head librarians from different types of libraries were the target sample identified via a self-selection non-probability sampling technique. The initial results yielded from the respondent sample indicate that the CRILM is deemed suitable for measuring change-readiness among library managers and libraries. However, it should be subjected to testing and use by a wider target group to further strengthen its usability. The results of the study offer help to library managers in assessing the readiness of their organizations to effectively manage change and be future-ready.


This paper construes'cultural studies' as a multidisciplinary theory which recognises the relationship between history, culture and power with the conviction that the nature of a people's history and culture, including their concepts of 'right' and 'wrong',are determined by a dominant group at the expense of the minority in any society. The paper shows that it is for this reason cultural critics discountenance expressions like 'factual history', 'true accounts of incidents', 'high art', 'low art' and similar others, which representsentiments of dominant groups in any society. Using new historicism and post-colonialism as key strands, the paper submits that cultural critics seek to change the existing culture by making it possible for the marginalised to be heard; therefore, giving such marginalised persons the means of influencing the culture of their societies. The paper has used Chimamanda Ngozi Adichie's Purple Hibiscus to discuss cultural analysis; concentrating on how the colonial culture is depicted in the work vis-a-vis indigenous culture(s), what characters have been used in the work, how characterisation is done, how valid the narrative is, how effectively the novelist has usedlocal expressions to replace those from the dominant culture in the work, and the presence of political statements in the novel as well as what motifs dominate in the novelshowing the writer's attitude to each of such motifs amongst other concerns.


Aiming at the problem of extensive use of bitmaps as icons in mobile applications (such as zooming problems, page opening speed, etc.), this article takes the front-end design of the Eurasian driving school website as an example, and introduces the use of font icons such as Awesome and GlyphiconsFont. The so-called font icon is actually a fontized icon instead of a picture, so it can be used as a font to reference, set the size, color, etc. of the icon, just change the font size and color, especially in mobile or responsive pages. more obvious.


What described herein is a mutant recombinant β- glucocerebrosidase protein characterized by having an increased stability relative to the recombinant wild-type β- glucocerebrosidase. The further provided herein is a mutant recombinant β- glucocerebrosidase protein, characterized in that retaining the higher catalytic activity relative to the recombinant wild-type β- glucocerebrosidase. What further described herein, the following positions: 316,317,321 and 145 is a mutant recombinant β- glucocerebrosidase protein which may have one or more amino acid mutations. Method of producing the mutant recombinant β- glucocerebrosidase protein, as well as also described a method of treating a patient with a lysosomal storage disease. .FIELD 1


Summary Individuals who are highly sensitive to tuberculin PPD develop a statistically significant elevation in serum alpha-1 globulin during their response to a PPD skin test. The implication of this finding with respect to the mechanism involved in tuberculin hypersensitivity is discussed.


The diagnostic performance of cardiac magnetic resonance (CMR) has not been compared with that of other imaging modalities. Therefore, this study investigated the diagnostic capabilities of CMR and endomyocardial biopsy (EMB) in patients with heart failure (HF).


The photocatalytic degradations of 32 water-soluble azo dyes were carried out using ferric oxalate complexes/ H2O2. Also QSPR studies on the photocatalytic degradation properties including decoloration value and half-time of the dyes were conducted by selecting molecular descriptors and multi-linear regression analysis. The results indicate that there is the significant linear correlation between the decoloration value and half-time and molecular descriptors, especially MW/S and number of azonic groups of azo dyes. Moreover, a QSPR model of azo dyes was achieved and used for calculation of predicted decoloration value and half-time of the dyes.


The main objective of the EUBerry project is to provide the necessary knowledge and tools to facilitate development of high quality, consumer-desirable fresh berry fruits of high nutritional quality optimal for human health at a competitive cost. The further objective is the development and validation of a set of tools to improve competitiveness of European berry production and consumer accessibility to berry fruits. The EUBerry platform will be developed and validated by using strawberry, raspberry, and blueberry as model crop species. Specific critical points related to improvement of berry fruit quality and reduction of production costs will also be considered for currants and blackberries. The EUBerry project will identify germplasm of the main berry fruit genera appropriate for sustainable production throughout Europe, expand high-quality production systems to improve availability of high-quality fresh berries for consumers, develop new methods to control and maintain fruit nutritional quality, validate the impact of new technologies for farmers and consumers, and disseminate and communicate the results to stakeholders and regulatory agencies.


【Objective】This study optimized the fermentation conditions of antagonistic strains to Botrytis cinerea,and explored their inhibitory effect preliminarily.【Method】D6and D10strains were isolated from the garlic bulb in earlier stage.Inoculum density,culture temperature,shaker revolution and loading volume as investigated factors,4factors and 3levels of orthogonal experimental were designed for optimized fermentation conditions of D6and D10.Their optimum shaker cultivation conditions and germfree fermented filtration inhibitory effect on B.cinerea mycelial growth were investigated.【Result】The obtained optimum shaker cultivation conditions were:D6inoculum density 4%,culture temperature 22 ℃,shaker revolution 180r/min and loading volume 50mL and D10:inoculum density 4%,culture temperature26℃,shaker revolution 150r/min,and loading volume 75mL.Highest inhibitory rates were up to 85.33%with the filtrate concentration of 15%and 70.67% with the filtrate concentration of 10%.When the temperature was 121℃,the filtration of D6was stable,while D10lost biological activity.【Conclusion】Germfree fermented filtrations of D6and D10had a striking inhibitory effect to B.cinerea.D6showed good thermal stability and should be further studied.


A comprehensive very compact finite element is proposed, able to describe the behaviour of 2D concrete structures from serviceability conditions up to the collapse. The formulation of this finite element is derived from a resistant criterion based on a plasticity theory approach, in which the deviation Δθ between the angle of first cracking and the compressed stress field at failure is the main key parameter to describe the structural behaviour. In practice the evolution of damage in the compressed concrete stress field is related to Δθ for every load step and increasing action level. The robustness of this finite element may be found in its compactness and then in the reduction of the number of input parameters, that are often difficult to define properly and may govern in a sensitive measure the structural response. The proposed F.E. is then used to reproduce some well know experimental tests, both on elementary panels and more complex 2D structures, showing a satisfactory capability to predict the 2D reinforced concrete structural behaviour


bicycle with a 100% increase using salbutamol or a 12% increase using portable oxygen. One must compare like with like. If increase in distance covered is the aim then a car would be better than a bicycle. The authors suggest that lightweight tricycles may be useful in rehabilitating patients with chronic airflow limitation, but they offer no evidence for their assertion that cycling is a good form of exercise for such patients. Controlled studies have shown that simple exercises, aimed mainly at the legs, can improve exercise tolerance and everyday activities in breathless patients.1 2 We are currently studying the mechanism of this improvement. It will be interesting to see whether, in a properly controlled trial, cycling is any better than simple exercises at improving the ability to walk and perform daily activities. Meanwhile, we hope that those breathless patients who can raise the necessary /250 do not all rush onto the roads on tricycles. Many of them are elderly with poor eyesight, hearing, and coordination and would be a hazard to themselves and other road users.


We construct a variational formulation for the problem of interpolating seismic data in the case of missing traces. We assume that we have derivative information available at the traces. The variational problem is essentially the minimization of the integral over the smallest eigenvalue of the structure tensor associated with the interpolated data. This has the physical meaning of penalizing the local presence of more than one direction in the interpolation. The variational problem is used to justify the solutions of a non-standard anisotropic diffusion problem as reasonable interpolated images. We show existence and uniqueness for this type of anisotropic diffusion. In particular, the uniqueness property is important as it guarantees that the solution can be obtained by the numerical schemes we propose.


In clinically evaluating a newly formulated coagulation factor concentrate for the treatment of hemophilia A or B patients, the initial study performed is typically one that examines the pharmacokinetics of the principal active factor. In recent years with the rapid development of higher purity concentrates and, particularly, ones produced by monoclonal antibody and recombinant DNA technology, there has been reported a spate of such studies. Unfortunately, there has been a large range of approaches to the design of these trials, and also in the data analytical and data reporting methodologies (1-4). This, of course, has made it quite difficult to compare the findings between these studies, and assess the similarities and differences among the new preparations. At the 1989 ISTH Meeting in Tokyo we proposed that an attempt be made to formulate a set of basic principles for the design and analysis of pharmacokinetic studies of factor VIII and IX. As such, we suggested a set of guidelines at the recent SSC meeting of the ISTH in Barcelona. These were duly reviewed and discussed, and this paper is an offshoot of the conclusions of that meeting. It is important to note that what we suggest here is primarily for clinical studies comparing a newly developed concentrate with an existing one or for the comparison of already marketed preparations. Pharmacokinetic studies on individual patients for diagnostic or therapeutic purposes may not necessarily need to follow these guidelines, and some aspects of the proposal may not even be appropriate.


In a lecture he gave at UCLA in 1948, nearly thirty years after the event, Erich Mendelsohn recalled the great scientist's one-word approval at the opening of the Einstein tower: "Einstein in person pronounces his scientific judgement: 'organic!'. . . I understand what he means: that you can't change or take away a part without destroying the whole." And a few sentences later he adds: "The principle of elasticity is dictated by nature. Upon it nature works in all her organisms?in her material, vegetable and animal kingdoms: in man and plant. This is the structural meaning of 'organic' architecture."1 Einstein's one-word compliment to Mendelsohn was very much in vogue, but it also had a long and involved intellectual history: Organic is from organon, the Greek word meaning "instrument" or "tool." Aristotle's group of writings, which is his main contribution to logic, came to be called the Organon, because it was thought to be a "collection of treatises constituting an instrument for the accurate verbal enunciation of all mental conceptions whatsoever," as a nineteenth-century commentator put it.2 The Scholastics and many later philosophers took over this notion of instrumentality. It was refined by Francis Bacon into a new logic, his Novum Organum, which was first printed in 1620. This was to be the second installment of his Instauratio Magna, in which deduction was replaced by induction as the primary intellectual procedure. Much later, Immanuel Kant did not think that an organon of Pure Reason, a "compendium of those principles according to which all pure cognitions a priori can be obtained,"3 could yet (or perhaps ever!) be attempted; his Critique?being concerned only with synthetic, and therefore excluding analytic a priori knowledge?could not be a complete system of pure reason. In Kant's conception, Organon had therefore shifted from being considered an instrumental compendium of the pieces that regulated the procedure of verbal formulation to a much more articulated notion: that


Drought resistance of different Lespedeza davurica materials at seed germination stage was evaluated. Seeds were exposed to five levels of osmotic PEG solution. Based on germination rate, relative germination rate, germination index, vigor index, root length and seedling height , the ability of drought resistances at germination stage of the different Lespedeza davurica materials was H04-17H04-5H98-45H98-16H02-2H04-3H98-67H98-24H04-7.


This paper presents an overview of the superconductive magnetically levitated system (maglev) program in the United States. Although the U.S. Maglev Program was once stopped in 1975, the increasing congestion in the U.S. transportation system in the late 1980's and other factors have led to a reawakening of national interest in Maglev technology. In 1990 the National Maglev Initiative (NMI) was established, and it funded 27 studies related to Maglev technologies and economics, and four System Concept Definition (SCD) studies. Technical requirements in the SCD and technologies in the SCD systems designed by teams led by Bechtel Corp., Foster-Miller Inc., Grumman Aerospace Corp. and Magneplane International, Inc. will be reviewed. A plan for the Maglev prototype development program proposed in the NMI program will be also presented.


Megakaryocytic maturation has two aspects, nuclear maturation and cytoplasmic maturation, both of which are affected by several thrombopoietic cytokines. We cultured murine bone marrow cells separated by BSA velocity sedimentation which contained more immature megakaryocytes with lower ploidy in order to study the effects of rhIL‐6 and rmSCF on the two aspects of megakaryocyte maturation. During culture with rhIL‐6 or rmSCF for 4 d, the megakaryocytes underwent endomitosis, resulting in DNA polyploidization. These two cytokines had different effects on cytoplasmic maturation. Flow cytometry showed that the megakaryocytes cultured with rhIL‐6 became larger and had a more complex intracellular structure than those cultured with rmSCF. Morphological studies showed that the megakaryocytes cultured with rhIL‐6 were larger and more granular, whereas those cultured with rmSCF were smaller and more basophilic. rhIL‐6 promoted cytoplasmic process formation by the megakaryocytes, but rmSCF did not. Analysis of transcripts of PF‐4 and GPllb by RT‐PCR suggested that rmSCF kept more megakaryocytes at the protein synthesis stage than did rhIL‐6. Based on our findings, these cytokines exert different effects on megakaryocytic cytoplasmic maturational events.


THE magnitude of the present global conflict has already outstripped the scope of all past wars. As a result of this, the public is being inconvenienced in various and sundry ways and is likely to be more than merely inconvenienced before the existing war is terminated. Against this somber backdrop of a rather foreboding future, the trials and tribulations of the last World War seem insignificant by comparison. Two things seem to have contributed to insuring that the inconveniences of the present war will develop into hardships of major importance, involving every segment of our civilian population. First, our enemies have acquired territories which contain substantial sources of supply of some of our basic raw materials. Second, the scope of unrestricted submarine warfare by our enemies has imposed severe shipping limitations upon certain imported consumer commodities. It has therefore been necessary for our Government to impose controls to prevent the reduction of existing stocks of materials below a point which might endanger this country's ability to successfully prosecute the present war. Certainly it has been necessary to husband drastically this country's basic critical materials so that its war production can be properly geared to full and complete utilization. War production control has thus been essentially a problem of cooirdination of the element of time so that the more important war plants can get first call on the most critical materials. On the other hand, so far as consumer's necessary goods are concerned, the problem is one primarily of an equitable distribution of the available stockpile. The priorities system is therefore used to effect war production control while an equitable apportionment of consumer's goods is obtained through the medium of rationing.'


Abstract : The dam is located in Warren County, New Jersey on the Musconetcong River. Erosion has damaged the right and left abutments. The downstream training wall at the left abutment of the dam has been undermined and collapsed. The visible portions of the concrete spillway crest and downstream face are badly cracked and spalled. Water is leaking underneath and through the base foundation of the old raceway structure along the right side of the dam. Numerous small trees are growing in the channel adjacent to the raceway foundation. The left concrete abutment is badly deteriorated. A major vertical crack was observed near the center of the dam and a portion is missing.


With the target of Zero-Defect Manufacturing, the European Project Industrial Data Services for Quality Control in Smart Manufacturing (i4Q) aims to develop 22 software solutions based on Artificial Intelligence (AI) to optimize manufacturing processes, ensuring quality, effectiveness and interoperability among manufacturing companies. The solutions will be implemented in real manufacturing scenarios, where the outcomes of the project will be tested and evaluated. One of the solutions, i4Q Line Reconfiguration Toolkit, will be deployed in FACTOR, a manufacturing company dedicated to metal machining and precision turning. This paper covers: (i) the introduction of the pilot case and the project solutions; (ii) the goal that FACTOR aims to achieve by the implementation of the solutions; (iii) the main features of the Line Reconfiguration Toolkit solution and their alignment with the requirements exposed by FACTOR, and (iv) the expected results when applying i4Q Line Reconfiguration Toolkit in FACTOR.


The tribological properties of MoS 2 microsized spheres (MS-MOS 2 ) with diameter of 0.5-3 μm modified by self-prepared surfactant quaternary ammonium salt of 2-undecyl-1-dithioureldo-ethyl-imidazoline (SUDEI) as an additive in base oil 500 SN were investigated and compared with those of commercial colloidal MOS 2 (CC-MOS 2 ) on a four-ball tester and an Optimol SRV oscillating friction and wear tester in a ball-on-disk contact configuration. The worn surfaces of the bottom flat disk were examined with scanning electron microscopy and X-ray photoelectron spectroscopy. It was found that the MoS 2 microsized spheres product was a much better extreme-pressure additive and antiwear and friction-reduction additive in 500 SN than commercial colloidal MOS 2 (CC-MoS 2 ). Under the appropriate concentration of 0.1% and 0.25% for MS-MOS 2 and CC-MoS 2 and the load of 400 N, the friction coefficient of MS-MOS 2 /oil and CC-MoS 2 /oil decreased about 25.0% and 12.5% and the wear volume loss decreased about 50.4% and 12.9% compared with the pure base stock. The boundary lubrication mechanism could be deduced as the effective chemical adsorption film formed by the long chain alkyl (C 11 H 23 ) and active elements (S and N) in the surfactant SUDEI and tribochemical reaction film composed of the tribochemical reaction products.


The invention discloses a method for synthesizing ethylene glycol distearate in the absence of a solvent at ordinary pressure. In the presence of a solid acidic catalyst, the ethylene glycol distearate is prepared under certain technological conditions with ethylene glycol and stearic acid as raw materials. According to the method disclosed by the invention, the ethylene glycol distearate product can be synthesized at high efficiency in the absence of the solvent at ordinary pressure, wherein the acid value of the product can be less than 5 at least, and the acid conversion rate of the product can reach over 97%. The method disclosed by the invention is simple and highly-efficient, convenient and feasible to operate, safe and environment-friendly, and free of toxicity pollution and recovery problem of the solvent and has better generalization and application value.


PROteolysis TArgeting Chimeras (PROTAC) technology has gained a tremendous momentum representing a completely new paradigm for the treatment of cancer or other severe human diseases [1]. Despite inhibiting, PROTACs are endowed with the ability to reduce the intracellular levels of a target protein by exploiting a cell's own protein disposal machinery. These heterobifunctional small molecules, composed of a ligand binding the target protein and an E3 ligase recruiter both connected by a linker, act as 'molecular bridges' that bring into close proximity the pathogenic target protein and the selected E3 ligase thus inducing the protein polyubiquitylation and its subsequent proteasomaldependent degradation [1]. To date, targeted protein degradation has been applied to a variety of proteins, such as transcription factors, skeleton proteins, enzymes, and regulatory proteins, with a major effort on cancer-related proteins [2]. Despite the increasing interest about the PROTACs synthesis and their biological activity, a rational design of PROTACs is still limited to the few cases in which the x-ray information on the ternary complex is available [3]. Indeed, for the in silico design of PROTACs a number of critical points are to be addressed, as for example, the optimization of the linker length and its anchor points. In addition, the selection of the most suitable E3 ligase is also a challenging task: nowadays, fewer than 10 of the more than 600 E3 ubiquitin ligases have so far been exploited by PROTACs [4]. In this context, it is noteworthy that the E3 ligase selection should be based not only on the best complementarity in the ternary complex formation, but also on its tissue expression, which might be highly variable [4]. In addition, the evaluation of the ADME properties of this class of compounds is still very limited and, concerning metabolic stability, the interaction of PROTACs with the major enzymes involved in metabolism has not been explored yet. Here, we report a review of the key points to be addressed to approach a rational design of PROTACs, and preliminary studies on PROTACs metabolism and their interaction with phase I enzymes are discussed.


Objective To verify the fact of myocardial insulin resistance phenomenon during cardiopulmonary bypass(CPB).Methods Twelve mongrel dogs underwent cardiopulmonary bypass were divided into two groups at random: groupⅠ(n= 6),aortic cross-clamping for 30min and group Ⅱ(n= 6),aortic cross-clamping for 120min.The plasma concentrations of glucose,insulin,C-peptide,glucagon,cortisol,growth hormone,and the change of "HOMA-IR" as well as myocardial glycogen contents were detected at pre-bypass,reperfused 15 min,45 min and 75 min respectively.Systemic hemodynamics was measured preoperatively.Results After myocardial ischemia-reperfusion,the plasma concentrations of glucose,insulin,C-peptide,glucagon,cortisol and growth hormone were all significantly increased and reached their peak levels during reperfused 15min and 45min in comparison w ith pre-bypass level(P0.05),meanwhile myocardial glycogenolysis was significantly increased and there was severe dysfunction in myocardial glucose uptaking and utilization.In comparison with group I,the degree of myocardial insulin resistance was markedly increased and lasted longer time.Conclusions Accompanied with typical peripheral insulin resistance,the phenomenon of myocardial insulin resistance significantly exists after myocardial ischemia-reperfusion with extracorporeal circulation.The increased extent of myocardial insulin resistance relies upon the duration of extracorporeal circulation


Zhu Xi's acceptation of Wang Wei was multiplicity.From the aesthetic evaluation perspective,he appreciated his poetic verses,Wangchuan genre and Wangchuan Painting;from moral evaluation perspective,he sharply criticized Wang's political disloyalty,which was even overwhelmed his aesthetic evaluation.The praise and derogation which seemed contradictory and disordered had its inherent logic related closely to Zhu Xi's political and aesthetic ideals of worshiping integrity,majesty and wateriness which was inseparable from his acceptation to Su Shi.Therefore it was quite meaningful in literature study to explore Zhu Xi's acceptation of Wang Wei and its influence in later generations.


1. Nine Ayrshire calves were subjected in a climatic room to temperatures in the range 15–41° C., and moisture vaporization rates were measured, by means of ventilated capsules, from various skin regions. 2. The rise in moisture vaporization rate, during the early part of exposures to high temperatures, occurred in a series of steps. This was attributed to bursts in sweat gland activity. 3. At low environmental temperatures the moisture vaporization rate was small and similar in all regions. At high temperatures evaporation differed widely between regions. The regional distribution was similar for all animals and agreed broadly with results that have been reported for other breeds. 4. The regional distribution of moisture vaporization was not appreciably altered as animals aged from 10 to 34 weeks, but the evaporation from all regions increased during this period.


Objectives: During bladder filling, the bladder starts to sense it and the sensation steadily increases. However, little is known concerning volume‐sensory correlation in normal bladder and pressure‐sensory correlation during detrusor overactivity (DO). We aimed to real‐time assess bladder sensation in normal bladder and DO using a five‐grade measure.


Objective To discuss the clinical value of ultrasonically activated scalpel(UAS) in breast cancer patients who underwent 2-3 cycles of neo-adjuvant chemotherapy by comparing UAS and electric knives (EI) in modified radical mastectomy. Methods From Jun.2009 to Aug.2011, 52 breast cancer patients taking 2-3 cycles of neo-adjuvant chemotherapy underwent modified radical mastectomy in our hospital. Among them, UAS group included 23 patients, and EI group included 29 patients.The 2 groups were compared in terms of the operation time, intraoperative blood loss, postoperative drainage tube duration, postoperative hospital stay, the number of lymph nodes retrieved, and the volume of subcutaneous hydrops.Results Between the 2 groups, the difference of intraoperative blood loss and postoperative drainage tube duration had statistical significance(P <0.01 ).The difference of operation time, hospital stay, and subcutaneous hydrops had statistical significance ( P < 0.05 ).The difference of the number of lymph nodes retrieved had no statistical significance ( P > 0.05 ).Conclusion There are good curative effects for breast cancer patients undergoing modified radical mastectomy by UAS and axillary lymph node dissection after neo-adjuvant chemotherapy, which is consistent with the conception of fast track surgery.

Key words:
Breast cancer;  Ultrasonically activated scalpel;  Modified radical mastectomy;  Fast track surgery;  Neo-adjuvant chemotherapy


This study utilises several theoretical perspectives and analytical scales to examine the constructed, conceptualised and socialised landscapes of the Hay Plain, characterised by the mounded cultural deposits, regionally known as 'mounds', 'earth mounds' or 'oven mounds'. Mounds are found in widely separated areas of Australia, with a major concentration on the Hay Plain and adjacent Murray Riverine Plain. Previous archaeological research into mounds has frequently failed to investigate explanatory relationships or investigate the dynamics of human behaviour. This study examines three major themes, each with different approaches and analytical scales. Firstly, the search for a fundamental explanatory model for the tightly bounded spatial and temporal patterns of mounds concluded that the distribution of mounds in. Australia is directly related to a mid to late Holocene focus on managed, dense, predictable carbohydrate-rich plant crops in varying habitats, which needed prolonged cooking in heat retainer ovens to maximise the energy return. Secondly, the study aimed to provide evidence of the intertwining of environment, human agency and historical processes, leading to generalised models of sociocultural change. The large and rapidly constructed mounds of the Hay Plain wetlands provide evidence of resource-use intensification proposed for the mid to late Holocene in other areas of Australia (Lourandos 1997, David & Lourandos 1998). Mounds appeared much later than suitable habitats for the wetland plant crops extensively cooked in mounds, and are not the direct response to evolving wetland habitats. They reflect complex social strategies constrained by habitat potential. Thirdly, as envisaged by Dobres (1995), concepts of interpretive archaeology such as landscape archaeology, style and gender were used as tools to examine the finer details and complexity of social processes that occurred on the Hay Plain. Mounds are constructed to 'style' templates and form an element of composed landscapes, which are appropriated, inscribed and socialised, forming palimpsests of meanings and memories reflecting social structures and histories. The results of this study demonstrate that range of complementary theoretical perspectives, temporal and spatial scales are necessary to provide a more comprehensive and holistic understanding of the mound-building phenomenon.


Idi-ayunre and Akure areas are part of the basement complex of southwestern Nigeria and are predominantly consisted of gneisses, granite and migmatite with some minor quartz veins and pegmatite. These rocks have been greatly weathered to form clay, laterite and soils. Chemical analysis were carried out on basement rocks and exposed profiles. The weathering profile was subjected to X ray diffraction (XRD) analysis to determine mineralogical compositions whereas Chemical Index of Alteration (CIA) was calculated from the elemental concentrated data. Weathering of basement rocks in Idi-Ayunre and Akure districts resulted in the formation of soil layer which ranged 0-0.4m, laterite layer 1.2-2.2m, and clayey zone 3.8-6.6m. Quartz, plagioclase, microcline, and biotite were the main minerals in parent rocks. Some of the primary minerals such as biotite and K-feldspar have been weathered to form kaolinite. Quartz, kaolinite and goethite formed the dominant minerals revealed by X-ray diffraction on decomposed granite sequences. The results from chemical analysis showed that Al and Fe have been enriched in weathering profiles of banded gneiss, migmatite gneiss and porphyritic granite whilst on the other hand Ca, Mg, Mn, Na, K, Ti were reported to be depleted.. Silica was relatively stable from basement to the topsoil in the profile. The CIA generally ranged between 80 - 99 The lateritic profiles over banded gneiss, granite and porphyritic granite of Idi-Ayunre and Akure areas varied with the composition of the parent rocks. The thick clayey layers could be of great economic importance for the production of ceramics wares and for constructional purposes.


This article studies the aggregation diffusion equation \[
\partial_t\rho = \Delta^\frac{\alpha}{2} \rho + \lambda\,\mathrm{div}((K*\rho)\rho), \] where $\Delta^\frac{\alpha}{2}$ denotes the fractional Laplacian and $K = \frac{x}{|x|^\beta}$ is an attractive kernel. This equation is a generalization of the classical Keller-Segel equation, which arises in the modeling of the motion of cells. In the diffusion dominated case $\beta \alpha$, we prove global or local well-posedness for an $L^p$ initial condition, depending on some smallness condition on the $L^p$ norm of the initial data. We also prove that finite time blow-up of even solutions occurs under some initial mass concentration criteria.


This study was done to explore communication between nurses during preceptorship. Methods: A qualitative study, using content analysis was conducted. Semistructured interviews were held with 10 nurses working in urban hospitals. Results: A total of 226 significant statements were selected from the data and classified into 4 categories and 23 subcategories. Communication experiences of new nurses' own performance were responses to reproach - acceptance and apology, and unresponsiveness due to feeling small and uncomfortable; responses to questions - misanswer; responses to directions - unconditional acceptance. Communication experiences of new nurses' performance by nurse preceptors were kindness, stigmatization, talking behind one's back, criticism and reproach, impolite words, and emotional expression. Communication experiences of nurse preceptors's own performance were directives, sympathy, reproach, unkindness, authoritative strictness, and nonverbal expression: being cold, and lessening of tension. Communication experiences of nurse preceptors' performance by new nurses were response to criticism - recognition and apology for mistakes, evasion of responsibility, and excuses; responses to explanations-active acceptance, and difficulty with communication due to lack of comprehension. Conclusion: These results provide deep understanding of nurses' communication during preceptorship and should help in developing comprehensive education programs for preceptor nurses and new nurses.


In order to alter the clay surface from hydrophilic to organophilic nature, the clay was modified by replacing its natural inorganic exchangeable cations with Quaternary Ammonium Cations (QACs). In this work, we studied the effect of QACs carbon chain length used for modifying Montmorillonite clay to examine its adsorption properties towards humic acid utilizing a batch equilibration technique. A comparative study was performed using Montmorillonite modified with 3 different QACs, which include Tetramethylam- monium (TMA), Hexadecyltrimethylammonium (HDTMA) and Benzyldimethylhexadecylammonium (BDHDMA). The Batch adsorption results demonstrated that HDTMA-Montmorillonite and BDHDMA-Montmorillonite are better adsorbent than the precursor and TMA-Montmorillonite. The adsorption affinity of Montmorillonite towards humic acid increased with an increase


Among illicit substances in all the world, psychostimulants fill the second place. Their bad use has greatly increased at the end of the eighties in parallel to the increases of varied party and to the research of putting up a good physical or intellectual performance. But their employment is not recent as it appears by their use at large scale during the Second world War and after it in Japanese society. A MEDLINE search from 1963 to 2002 was done to identify the literature published on psychostimulants and their sociocultural use, their basic chemistry, their pharmacology and more specifically their psychiatric uses and indications in thymic and obsessive compulsive disorders. The references of articles found were evaluated for other relevant articles.


This memo proposes two mechanisms that work in concert to allow a
third party (e.g., a content delivery network) to terminate TLS
sessions on behalf of a domain name owner (e.g., a content provider).
The proposed mechanisms are:


Let Lp(V) denote the pth Lie power of a finite-dimensional module V for a group G over a field of prime characteristic p, where Lp(V) is regarded as a submodule of the tensor power Tp(V). There is a natural homomorphism from Lp(V) onto the pth metabelian Lie power Mp(V). We show that the kernel of this homomorphism is a direct summand of Tp(V) and apply this result to the generic case where G is the general linear group on V and the field is infinite. In this case we find the indecomposable direct summands of Lp(V) and their multiplicities.


This paper is the first one of two serial articles, whose goal is to prove convergence of HX Preconditioner (proposed by Hiptmair and Xu 2007) for Maxwell's equations with jump coefficients. In this paper we establish various extensions of the regular Helmholtz decomposition for edge finite element functions defined in three dimensional domains. The functions defined by the regular Helmholtz decompositions can preserve the zero tangential complement on faces and edges of polyhedral domains and some non-Lipchitz domains, and possess stability estimates with only a $logarithm$ factor. These regular Helmholtz decompositions will be used to prove convergence of the HX preconditioner for Maxwell's equations with jump coefficients in another paper (Hu 2017).