We present time resolved X-ray diffraction (TRXD) experiments on the transport of a coherent acoustic wave-packet and nonlinear carrier relaxation processes across the nearly ideal AlGaAs/GaAs interface. A femtosecond laser impulsively excites the underlying substrate such that the coherent acoustic phonons take the form of two counter propagating unipolar strain pulses and associated hot carrier dynamics. Picosecond TRXD is used to observe the laser-induced strain separately for the film and substrate.


Six bulls were fed with concentrate without bone meal, fishmeal and other animal materials at Shaanxi Provincial Domestic Animal Improvement Station in two years, no significant change can be observed in semen quality and growth and development of bulls.


Abstract : Refugee support operations have significantly impacted the international community in recent years. Internationally sponsored humanitarian aid is almost always required to ease refugee suffering and misery. Historical evidence indicates that the use of military forces to assist governmental and non-governmental agencies in administering refugee support missions is increasingly becoming the norm. Additionally, the National Security Strategy of the United States outlines refugee support as a priority mission. As a consequence, military leaders must be prepared to plan and execute refugee support operations. This monograph proposes that the analysis of previously conducted refugee support operations will reveal a set of planning considerations relevant to future refugee support missions. These considerations can be organized within the operational function framework as defined in Joint Publication 5-00.1, Doctrine for Joint Campaign Planning. The planning design elements include command and control, intelligence, movement and maneuver, support and protection. Operation Provide Comfort and Operation New Life form the historical database for the analysis. This study concludes that the proposed planning considerations are valid for use in future refugee support operations. Development of a new planning framework for each RSO is unnecessary. Furthermore, the monograph recommends including the proposed design elements in doctrine. Additionally, the monograph identifies the primacy of unity of effort and cultural analysis during refugee support planning. Institutional school training and unit training are recommended methods to achieve the required level of training in these non-standard areas.


Abstract We briefly review our current understanding of how the solar differential rotation and meridional circulation are maintained, which has important implications for understanding cyclic magnetic activity in the Sun and stars.


A new, scalable, open-source code for simulating gas flow can compute larger-than-ever models using the Direct Simulation Monte Carlo method.A new, scalable, open-source code for simulating gas flow can compute larger-than-ever models using the Direct Simulation Monte Carlo method.


Data from different analyses of reported deaths from overdose with antidepressants in the U. K. reveal that amitriptyline and dothiepin are the antidepressants most likely to be associated with death from overdose. All widely used tricylic antidepressants (TCAs) except clomipramine and lofepramine appear to be dangerous in overdose, whereas the newer antidepressants such as mianserin, trazodone, viloxazine and the TCA lofepramine appear to be relatively safe. The toxicity of amitriptyline and dothiepin appears to be greater than all antidepressants including other TCAs and it is important to try to understand why. A number of explanations will be considered:


The situation of technical teaching in Morocco shows that there are shortcomings which seem to persist despite the reforms the Moroccan educational system has undergone. It is no longer about describing this teaching's current situations, but it is, above all, about finding a remedy to them by admitting that the linguistic problems the students encounter deprive them from persevering in the technical domain. The survey we have conducted within the Electric Engineering Branch at L'Ecole Superieure de Technologie (College of Technology) in Agadir has allowed us to detect the causes that strongly relate to the French language and the teaching of scientific subjects in secondary schools. Analyzing the direct consequences on the students learning process will allow us to handle the problem correctly and suggest some solutions.


A method of controlling the oxygen content in an enclosed space (1), especially a sports / exercise space, wherein: - a in the space included (1) gas mixture with a in the space (1) arranged ventilation system (8), which is controlled by means of a control device (18) is circulated, - incorporated in the ventilation system (8) an oxygen-free gas and / or an oxygen-containing gas mixture and in the ventilation system (8) in the space (1) with the gas mixture from the space (1) is mixed to a predetermined oxygen content in the gas mixture to be generated by <21%, and thus in the chamber (1) an atmosphere at a certain height above sea level to simulate, - the supply of the oxygen-free gas and / or the oxygen-containing gas mixture as soon as the predetermined oxygen content is reached is closed, - the mixing of the gas mixture containing the introduced oxygen-free gas and / or the introduced oxygen gas mixture by means of the ventilation system (8) in the space (1) at ...


There are a number of reports concerning the sonochemical synthesis of functional nanoparticles. However, the formation mechanism under ultrasonic irradiation has not yet been investigated sufficiently. It is important to understand the reduction mechanism of metal ions under ultrasonic irradiation, because the reduction reactions are often applied to the synthesis of various types of nanoparticles [1-3]. In this study, we have investigated the sonochemical reduction of MnO4 to MnO2 in the presence of organic additives under Ar atmosphere. It is well known that MnO2 is one of the useful materials for the application to Li-batteries, sensors, catalysts, etc. Although MnO2 nanoparticles have been synthesized by the sonochemical reduction of MnO4 [4-7], the reduction mechanism in the presence of organic additives has not yet been investigated sufficiently. Here, we have reported the effects of organic additives on the reduction of MnO4 to MnO2 during ultrasonic irradiation.


Abstract : Gun barrel vibrations lead to dispersion in the shot patterns. Thus, reducing these vibrations should lead to increased accuracy. Since the muzzle is the anti-node for all vibration modes and its vibrations have the greatest effect on shot dispersion, it is the obvious location to attempt to dampen the vibrations. A model of the gun barrel was created in MATLAB(registered) and verified by modal impact testing. Modal impact testing was done for the barrel alone and for three different muzzle brake vibration absorber configurations. Significant reductions in muzzle vibrations were achieved using the vibration absorber. Methods of making the vibration absorber adaptive and models of such a system are presented.


We address two different mechanisms used to make reliable an unreliable multicast over IP. The first mechanism uses an ARQ technique in each router of the multicast network. The second mechanism uses a peer-to-peer network where the peers are the destination nodes of the multicast tree to make reliable the unreliable multicast. We report an analytical model for the packet loss probability in a generic multicast network. We present an analytical model for the ARQ reliable multicast and an analytical model for the unreliable multicast with a peer-to-peer reliability network. Eventually we compare the two mechanisms through a simulator with respect to the average access time.


Congenital spine deformation caused by vertebral malformation is reported in different brachycephalic dog breeds, but also in other large dog breeds. The most severe clinical signs are due to spinal cord compression. Depending on localisation of the lesion, clinical signs can manifest differently. A five-month-old pug was brought for autopsy to the Department of Forensic Veterinary Medicine, Faculty of Veterinary Medicine, University of Belgrade. The first clinical signs, including general weakness and difficulty to jump appeared when he was three and a half months old. They became more severe until the dog was four months old. Radiography and myelography showed severe kyphosis and spinal cord compression in the T8-T9 region. After euthanasia, an autopsy was performed. Pathomorphological examination showed severe deformation of the spine, kyphosis and a wedge-shaped T8 vertebra. Although, literature data indicates that clinical signs can be latent until five or six months of age, this case shows that even in young puppies, three to four months old, serious clinical signs can be present. This is of great clinical importance, not just for veterinarians, but also for brachycephalic dog owners and breeders.


The effectiveness of sanctions applied to corporate offenders has not been adequately studied, in part because of the absence of any appropriate research strategy. This absence stems from the tendency. since Sutherland, to conceptualize corporate crime as individual rather than organizational behavior. This article outlines a research procedure based on the organizational nature of corporate crime and uses it to evaluate the impact of prosecutions under Australia's Trade Practices Act. The article concludes that the sanctions applied have considerably reduced the likelihood of corporate recidivism.


Abstract : Our laboratory is studying the polyurethanase enzymes and genes that encode them from three species of Pseudomonas. We have purified and characterized five polyurethane hydrolyzing proteins and cloned four polyurethanase genes, in which two have been sequenced. Nucleotide sequencing of the polyurethanase genes revealed that the deduced polypeptide sequence contains a serine-hydrolase consensus sequence GXSXG. The polypeptides lacked an N-terminal signal peptide, but did contain a short region toward the C-terminus that has been observed in secreted. The most closely related proteins to the polyurethanases had amino acid sequences homologies of 70% for four lipases from P. fluorescens and 51% for lipases from Serratia marcescens. Northern blot analysis revealed that the polyurethanase genes are constitutively expressed. The results obtained from this study has yielded valuable information that is essential for an understanding of the biochemical and genetic properties of bacterial polyurethanases and how these properties may be utilized to improve polyurethane degradation. The study has a potentially major impact on understanding mechanisms by which enzymes degrade polyurethane.


On the basis of survey represented a social portrait of the young people of Donetsk region. Comparative characteristics of the proposed socio-economic and political situation of youth in the region of all Ukrainian youth. The features of development and actual needs of the Donetsk youth.


Major depressive disorder (MDD) is a leading contributor to disease burden worldwide. Previous genetic studies have revealed significant evidence of linkage of the CREB1 region to mood disorders among women from families with recurrent, early‐onset MDD (RE‐MDD), a severe and familial subtype of MDD. Systematic resequencing of the CREB1 gene in affected members of these families has identified rare sequence variants at positions −656 and −115 that appear to cosegregate with unipolar mood disorders in two large multigenerational families and three small nuclear families, respectively. Results from previous transfection experiments that employed constructs containing the wild‐type or variant CREB1 promoters coupled to a reporter gene support the hypothesis that the A−656 allele contributes to the development of MDD in women by selectively increasing the activity of the CREB1 promoter in brain cell lines exposed to 17 β‐estradiol. Analogous transfection experiments described in the current study revealed that the G−115 promoter variant reduced promoter activity in CATH.a neuronal cells regardless of the hormonal environment, consistent with the observation that increased risk for unipolar mood disorders conferred by this allele was not limited by sex. The effects of CREB1 promoter variants on promoter activity, their influence on the development of mood disorders and related clinical features, and the interaction of their phenotypic expression with sex seem likely to be complex and allele‐specific rather than a general property of the CREB1 locus. © 2010 Wiley‐Liss, Inc.


To reduce the fluctuation of frequency response of a Distributed Feedback(DFB) fiber laser used in underwater sound detection,an encapsulated structure with orifices was designed.With the encapsulated structure,both ends of the DFB fiber laser were fixed along the axes of the structure by the tension of polyurethane,and the fluctuation of mid-frequency response was restrained.The dynamics of the encapsulated structure was numerically analyzed with ANSYS,and a prototype of the new kind of hydrophone based on the structure was produced and tested with the vibration fluid column method.The results show that the fluctuation of frequency response of the DFB fiber laser is restrained effectively from 20 Hz to 800 Hz,and the acoustic pressure sensitivity reaches to-131 dB with the fluctuation less than ±1.5 dB.These results demonstrate that the performance of the DFB fiber laser hydrophone has been improved by the protection of the encapsulated structure and the tension of polyurethane.


43 stands of a dry tropical forest vegetation occurring in the Vindhyan region of India were studied and the data were analysed using multivariate methods. The vegetation comprised five community types forming a mosaic and was distributed in non-contiguous patches. The environmental relationships of these community types were analysed by Detrended Correspondence Analysis and Discriminant Analysis, which illustrated the importance of soil texture in determining the distribution of these communities. Analysis of data for saplings indicated the dynamic nature of patches and of the community types. We conclude that dry tropical forest vegetation is a mosaic of communities which are dynamic in space and in time.


A 24-year-old man was referred to our hospital for detailed examination of a chest radiograph abnormality. He was asymptomatic and his personal history was unremarkable. He had never smoked. The chest radiograph revealed hyperlucent left lower lobe (Picture A). A computed tomography scan of the chest revealed hyperexpansion of the anterior segment of the left lower lobe with preserved bronchovascular markings (Picture B-D). A bronchoscopic examination revealed no obstructive endobronchial lesion. These findings were compatible with congenital lobar emphysema (CLE). Respiratory function testing revealed no abnormalities, and he is now being closely followed-up. CLE is an uncommon bronchopulmonary malformation that nearly always presents in infants. It is characterized by overinflation of a pulmonary lobe and compression of surrounding lung parenchyma, often leading to respiratory dis-


Privacy notices aim to make users aware of personal data gathered and processed by a system. Body-worn cameras currently lack suitable design strategies for privacy notices that announce themselves and their actions tosecondary andincidental users, such as bystanders, when they are being used in public. Hypothesizing that the commonly used status LED is not optimal for this use case, due to being not sufficiently understandable, noticeable, secure and trustworthy, we explore design requirements of privacy notices for body-worn cameras. Following a two-step approach, we contribute incentives for design alternatives to status LEDs: Starting from 8 design sessions with experts, we discuss 8 physical design artifacts, as well as design strategies and key motives. Finally, we derive design recommendations of the proposed solutions, which we back based on an evaluation with 12 UX & HCI experts.


In addition to proper selection of teeth for treatment, successful root canal therapy depends on the satisfactory com pletion of the endodontic triad— canal enlargement, canal "sterilization" and canal obturation.1 I t seems unreasonable to place particular emphasis on any one of these requirements, since inadequate attention to any of the phases usually results in failure. Nonetheless, dental literature is replete with papers assign ing greater importance to one division or the other of the triad. The purpose of this paper is not to stress the significance of any particular endodontic procedure, but rather to evaluate the role of mechanical instru mentation in the reduction of the bac terial flora of the canal. The methods employed in this investi gation are not advocated for use in rou tine clinical treatm ent; these endodontic procedures were used only for the pur pose of obtaining the information pre sented in this paper and in a subsequent one.


Objective. The study of dispositional predictors of students' conflict resilience.Background. Against the background of the consequences of self-isolation and the limitations of real communication, it is relevant to study resilience to conflicts as an important communicative and professional characteristic of social self-determination. The study of dispositional predictors of conflict resilience allows creating scientifically based programs for its formation among students.Study design. The influence of the severity of stress, aggression, empathy, assertiveness and other independent variables on conflict resilience, considered as a dependent variable, was studied. Statistical hypotheses were verified by means of factor analysis and structural equation modeling (SEM).Participants. The sample consisted of students of the natural sciences and humanities faculties of St. Petersburg State University in the number of 205 people, 49 of them men (24%) and 156 women (76%), aged 17 to 27 years, the median value is 19 years.Methods (tools). Questionnaire Determination of the level of conflict resilience (N.P. Fetiskin, V.V. Kozlov, G.M. Manuilov); Personality assertiveness test (V.P. Sheinov); PSM-25 psychological stress scale, in adaptation by Vodopyanova N.E.; diagnostic questionnaire for empathy A. Mehrabian, N. Epstein; diagnostic questionnaire for indicators and forms of aggression A. Bass, A. Darkey.Results. Because of confirmatory factor analysis, the variables stress, hostility, irritation were combined into the factor "paranoia" (suspicion, suspiciousness, resentment, stress and irritability). The variables verbal, physical, indirect types of aggression and negativism are combined into the factor "aggressiveness" (contradiction to the norms of society and the focus on causing harm to others). The variables empathy, assertiveness (–), guilt are combined into the "tolerance" factor (empathy, the desire to understand the reasons for the behavior of another, compliance and auto-aggression due to regular sacrifice of one's own interests). The joint influence of these factors on conflict resistance was revealed, the total variance is 55%. "Paranoia" and "aggression" reduce conflict resilience and promote conflict striving, "tolerance" enhances conflict resilience, but at high values, causes conflict avoidance.Conclusions. Psychological dispositions that affect conflict resilience can be combined into three factors: paranoia, aggression, tolerance, which have a multidirectional effect. Paranoia and aggression promote conflict-seeking behavior and reduce conflict resilience. Tolerance increases conflict resilience, but contributes to conflict avoidance. This conflict resilience dynamics can be described by an inverted V-shaped curve, which shows that conflict resilience arises because of a balance of the identified factors.


Image processing will play an important role for IoT (Internet of Things) applications. Nevertheless, noisy or erroneous images may invalidate image processing circuits. In the literature, there have been several image repair methods developed. However, most of them target noises. Erroneous images due to faulty circuits are seldom addressed. Although some previous work deals with this issue, single-bit errors are assumed. In this work we consider multiple-bit errors in the images produced by faulty circuits. Such erroneous images are first analyzed. Accordingly challenges for the previous image repair methods to deal with multiple-bit errors are discussed. Then the proposed image repair method that can overcome these challenges is presented. To evaluate the effectiveness of the proposed method, a large number of benchmark images that contain various significances of multi-bit errors are employed. The experimental results show that by using the proposed method, the image quality can be enhanced more effectively than the previous work.


The aim of this study was to evaluate and quantify variation in sensory attributes along the Longissimus dorsi (LD) muscle in rabbits. A descriptive analysis was performed by a panel of 8 assessors previously trained in the evaluation of rabbit meat. Reference standards used in training for the evaluation of rabbit meat are also described. Sensory attributes rabbit and liver odour, rabbit and liver flavour, toughness, juiciness and fibrousness were assessed in 56 rabbits from a divergent selection experiment for intramuscular fat (28 slaughtered at 9 wk and 28 slaughtered at 13 wk). Immediately after cooking, loins were cut lengthwise into 4 equidistant pieces from caudal to cranial end (LD 1 , LD 2 , LD 3 and LD 4 ). Assessors were able to detect and quantify a longitudinal sensory variation in muscle LD. Caudal extreme LD 1 was tougher and more fibrous than LD 2 , LD 3 and LD 4 , and less juicy than LD 3 and LD 4 . The greatest variation was found between caudal and cranial ends, with LD 1 being 9% tougher (P=0.99), 11% more fibrous (P=1.00) and 12% less juicy (P=0.99) than LD 4 . Assessors found few variations along LD muscle in flavour and odour attributes. Location LD 3 showed 9% greater rabbit odour (P=0.99) and flavour (P=0.97) than LD 4 , and 8% greater rabbit odour than LD 2 (P=0.97). Our results highlight the importance of randomisation within muscle location in sensory studies on rabbit LD muscle, as there is considerable sensory variation along this muscle.


Modulus of elasticity is an important mechanical parameter in analysis and design of reinforce concrete structures. The present value of modulus of elasticity ,which has rare relation with ratio of reinforcement ,is based on plain concrete. Authors deduced an equation between modulus of elasticity and ratio of reinforcement, and then an experimental study was conducted on 11 groups' component of reinforce concrete with different ratio of reinforcement. At last, an equation for modulus of elasticity of different ratio of reinforcement determined by regression, using least squared method, was described. A cantilever, whose dynamic characteristics and response were calculated, was taken as an example to analyze influence of ratio of reinforcement on the structural analysis .Result shows that ratio of reinforcement has effect on modulus of elasticity . Moreover, if general modulus is ignored when calculate dynamic response, it will cause deviation.


2 This Annex contains our detailed comments on the first two of these analyses, to be read in addition to the issues explained in Section 3 above. Following a comprehensive review of each of these analyses by our advisers, we consider that the results of these analyses do not support the CMA's AEC findings. In particular, we do not believe that the CMA has identified reliable evidence of customer detriment, and the analysis is not sufficiently representative or sound to justify a market-wide mandatory tendering remedy.


The Raman spectra of cholestan-3-one, 2α-bromocholestan-3-one (1), 2β-bromocholestan-3-one (5), and 2α-bromo-2β,4,4-trideuteriocholestan-3-one (2) between 150 and 1000 cm–1 have been recorded. Frequencies have been calculated for 2α-bromo-4,4,5β-trimethylcyclohexanone (3), 2β-bromo-4,4,5β-trimethylcyclohexanone (8), and the corresponding 2,6,6-trideuteriated species (4) and (9). From consideration of the calculated frequencies and the recorded Raman spectra, a strong band observed at 625 cm–1 has been assigned to an essentially carbon–bromine stretching mode of the axial bromocholestan-3-one. A number of modes between 800 and 200 cm–1 in the spectrum of the equatorial bromo-compound involve an appreciable potential energy contribution from carbon–bromine stretching, although no vibration is primarily a carbon–bromine stretch. Substantial changes in the natures and frequencies of these modes are exhibited on deuteriation at the 2-axial, 4-axial and 4-equatorial positions (of the steroid).


Background A role for vitamin D in cancer risk reduction has been hypothesized, but few data exist for lung cancer. We investigated the relationship between vitamin D status, using circulating 25-hydroxyvitamin D [25(OH)D], and lung cancer risk in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish male smokers. Methods Lung cancer cases (n = 500) were randomly selected based on month of blood collection, and 500 controls were matched to them based on age and blood collection date. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate-adjusted conditional logistic regression. To account for seasonal variation in 25(OH)D concentrations, season-specific and season-standardized quintiles of 25(OH)D were examined, and models were also stratified on season of blood collection (darker season = November–April and sunnier season = May–October). Pre-determined, clinically-defined cutpoints for 25(OH)D and 25(OH)D as a continuous measure were also examined. Results Overall, 25(OH)D was not associated with lung cancer. Risks were 1.08 (95% CI 0.67–1.75) and 0.83 (95% CI 0.53–1.31) in the highest vs. lowest season-specific and season-standardized quintiles of 25(OH)D, respectively, and 0.91 (95% CI 0.48–1.72) for the ≥75 vs. <25 nmol/L clinical categories. Inverse associations were, however, suggested for subjects with blood collections from November–April, with ORs of 0.77 (95% CI 0.41–1.45, p-trend = 0.05) and 0.65 (95% CI 0.37–1.14, p-trend = 0.07) in the highest vs. lowest season-specific and season-standardized quintiles of 25(OH)D, respectively, and 0.61 (95% CI 0.24–1.52, p-trend = 0.01) for ≥75 vs. <25 nmol/L. We also found 11% lower risk for a 10 nmol/L increase in 25(OH)D in the darker season based on the continuous measure (OR = 0.89, 95% CI 0.81–0.98, p = 0.02). Conclusion In this prospective study of male smokers, circulating 25(OH)D was not associated with lung cancer risk overall, although inverse associations were suggested among those whose blood was drawn during darker months.


The scattering support is an estimate of the support of a source or scatterer, based on a limited set of far field measurements. In this paper, we suppose that the far field is measured at all wavenumbers, but only at a few, say N, angles θi ϵ Θ. From these measurements, we produce a Θ-convex polygon (a convex polygon with normals in the θi directions). We show that this polygon must be contained in the smallest Θ-convex polygon which contains the source. We also show by explicit construction that, if (and only if) that polygon has almost 2N faces, there really is a source, supported in the Θ-convex scattering support, which exactly produces these measurements.


In preparing low-temperature fuel cell electrodes, a polymer binder is essential to bind discrete catalyst particles to form a porous catalyst layer that simultaneously facilitates the transfer of ions, electrons, and reactants/products. For two types of polymer binder, namely, an A3-an anion conducting ionomer and a PTFE-a neutral polymer, an investigation is made of the effect of the content of each binder in the anode catalyst layer on the performance of an alkaline direct ethanol fuel cell (DEFC) with an anionexchange membrane and non-platinum (non-Pt) catalysts. Experiments are performed by feeding either ethanol (C2H5OH) solution or ethanol–potassium hydroxide (C2H5OH–KOH) solution. The experimental nion-conducting ionomer


ZnO nanowires have been grown on Au coated n-Si (111) substrates by chemical vapor deposition and Au catalytic technology.The structure and morphology of ZnO nanowires had been studied by X-ray diffraction (XRD) and scanning electron microscope (SEM).It is found that ZnO nanowires are highly orientedly grown in the direction of (0001).SEM images of ZnO nanowires have shown that the typical diameter and length of ZnO nanowires are 100nm and 2~5μm,respectively.The growth mechanism of ZnO nanowires has also been discussed.


priorities pennit. The comments should not exceed 350 words in length, with a maximum offive references; onefigure or table can be printed. Exceptions may occur under particular circumstances Contributions may include comments on articles published in this periodical, or they may be reports of unique educational character: Specific permission to publish should be cited in a covering letter or appended as a postscript. f \


Laminar burning velocities of dimethyl carbonate (DMC) + air flames at initial gas mixture temperatures of 298, 318, 338, and 358 K are reported. Nonstretched flames were stabilized on a perforated plate burner at atmospheric pressure, and the laminar burning velocities were determined using the heat flux method. The overall accuracy of the burning velocities was evaluated to be typically better than ±1 cm/s. The effects of unburned mixture temperature on the laminar burning velocity of DMC were analyzed using the correlation SL = SL0 (Tu/Tu0)α. The present experimental results indicated that the power exponent α reaches a minimum in slightly rich mixtures corresponding to the maximum burning velocity. Modeling of these results has been attempted using the mechanism developed by Glaude et al. It was found that this model significantly overpredicts laminar burning velocities of methanol, ethanol, and DMC; however, it accurately reproduces the temperature power exponent α for dimethyl carbonate flames.


This article deals with the problem of clayey sludge utilization of diamondiferous ore enrichment. Thickening of saponite sludge by means of chemical treatment is currently considered as the most effective way to clarify the volume of water sufficient to maintain the recycling water supply of the enterprise and, as a consequence, to reduce the volume of additional water introduced into the process. The authors propose a new coagulant for settling saponite sludge - sodium sulfate mixture, which is a by-product of aluminum production. The use of sodosulfate mixture will reduce the amount of waste for both the diamond mining plant's concentrator and the alumina production. The question of the mechanism of interaction of saponite sludge particles with the proposed reagent is considered. The aim of the research is to find physical and chemical regularities of interaction of clayey slime particles with sodosulfate mixture. Chemical and mineral composition of used raw materials, surface charge of clay particles, granulometric composition of experimental samples and their electrokinetic potential were determined in the work. The results of the studies showed that the mineral composition of the clay slurry includes the following minerals: saponite, kaolin, serpentine, beidelite, dolomite. The surface charge of clay particles is negative. The chemical composition of the soda-sulfate mixture is represented in the form of oxides: Na2O, SO3, CO2, Al2O3. The dependence of the electrokinetic potential on the mass of the mineral additive introduced into the slurry was revealed. It was noted that the absolute value of ζ-potential remains above 30 mV despite increasing the concentration of the additive, but coagulation of clay particles occurs and the system in question loses sedimentation stability at a concentration of sodium sulfate mixture of 14.4 g/l.


The radiative widths of K−p→ Λγ and K−p→ Σγ decays are estimated within the baryon pole model and are compared with recent experimental rates. In the present calculation the role of the vector meson K1(1270) is shown to be important for the consistent agreement with the experimental data, subsidiary to the significance of Λ(1405) exchange from the parity conservation. Our results are presented for both of pseudoscalar and pseudovector couplings and are compared with those of other model calculations. Based on these results, discussions are given for estimates of the radiative widths ΓΛ1405→Λγ and ΓΛ1405→Σ0γ .


Abstract In response to the Every Student Succeeds Act (ESSA) (2015), 36 U.S. states have adopted chronic absenteeism as an indicator of school quality and student success. It is also being increasingly utilized within schools to identify students at risk for future educational problems, as research consistently shows that early absences are related to later achievement issues. By leveraging readily available attendance records, schools can identify students at risk of poor outcomes early in their educational lives and provide them with supports before challenges worsen. Despite its pervasive use, major theoretical assumptions underlying this indicator have never been validated. The current study represents the first empirical test of the most basic assumption of chronic absenteeism—that all absences from school are equally useful in providing diagnostic information to determine future risk status. To test the diagnostic utility of different absence types across the early elementary grades, this study employed ROC analyses with administrative data from a large, urban school district. Findings indicate that only unexcused absences provide diagnostic accuracy in determining future achievement status in the early elementary grades, whereas excused absences provide no diagnostic accuracy and actually dampen the ability of unexcused absences to determine students' achievement risk status when used in conjunction with them. These results have implications for researchers, policymakers, and practitioners and necessitate additional empirical studies that test the underlying assumptions of chronic absenteeism to ensure that it is being used both effectively and ethically in the early identification of at-risk students.


This article aims to examine the pattern of relationships that occur between cigarette companies, middlemen and tobacco farmers in the context of the political economy. General facts show that the price aspect is the point where tobacco farmers are structurally dependent on companies and middlemen. This pattern is examined in detail with the construction of the core-periphery principle in political economy. Descriptive approach is supported by literature study and analyzed with content analysis approach. The results obtained are, firstly, the scheme of dependency patterns between companies, middlemen and farmers. Secondly, the government policy in the breaking the chain of structural dependency is investigated. Underlying on these results, this article proposes optimal ways to control the structural linkage between companies, middlemen and tobacco farmers.


Dementia is a syndrome chronic or progressive that usually affects the cognitive functioning of the subjects. Alzheimer's, a neurodegenerative disorder, is the leading cause of dementia. One of the many symptoms of Alzheimer's Dementia is the inability to speak and understand language clearly. The last decade has seen a surge in the research done in Alzheimer's Dementia detection using Linguistics and acoustic features. This paper takes up the Alzheimer's Dementia classification task of ADReSS INTERSPEECH-2020 challenge, "Alzheimer's Dementia Recognition through Spontaneous Speech: The ADReSS Challenge". It uses eight different acoustic features to find the attributes in the human speech production system (vocal track and excitation source) affected by Alzheimer's Dementia. In this study, the Alzheimer's dementia classification is performed using five different Machine Learning models using ADReSS INTERSPEECH-2020 challenge dataset. Since most of the studies in the previous literature have used linguistic features successfully for Alzheimer's dementia classification, the current study also demonstrates the performance of the BERT model for the dementia classification task. The maximum accuracy obtained by the acoustic feature is 64.5%, and the BERT Model provides a classification accuracy of 79.1% over the test dataset. Finally, the score-level fusion of the acoustic model with the BERT Model shows an improvement of 6.1% classification accuracy over the BERT Model, which indicates the complementary nature of acoustic features to linguistic features.


Abstract Poly(ethylene adipate) (PEA) and poly(ethylene dodecanedioate) (PED) with dicarboxy-, dihydroxy-, dimethyl ester- and hydroxy-carboxy end-groups were synthesized and characterized by 13C NMR and MALDI-TOF MS. Size-exclusion chromatography (SEC) fractions of these polyesters were analyzed by MALDI-TOF MS and used as standards to obtain SEC calibration curves leading to the absolute molar masses of the unfractionated polyesters. PEA and PED calibration curves were different from each other, but the same calibration curve was obtained for each type of polyester, irrespective of the nature of end-groups, showing the predominant role of the nature of repeating units on the hydrodynamic volume of oligoesters. The study also shows that the conventional SEC calibration method using polystyrene standards leads to a significant overestimation of polyester average molar masses.


This paper addresses the output feedback control problem of networked robot systems characterized by Lagrangian function. Distributed observers are established to estimate the velocities of the agents by only using position information. It is shown that the estimated velocities can converge to their true values under the condition that the position information of the agents are uniformly bounded. By using the estimated velocities, distributed observer-based protocol which provides uniformly bounded position information is established. Lyapunov-like function is constructed to show that the state errors of the agents converge to zero globally.


The invention relates to a thermal management device of a power train comprising a main housing (1) accommodating an electric motor (2) and its cooling circuit and a reduction gear (3) comprising a lubrication circuit. Said main housing comprises an oil sump (20) arranged in the lower portion of said main housing and a partition (4) into two parts which are arranged respectively on the one hand, said motor (2) and its cooling circuit and on the other hand, said reducer (3) and lubricating circuit, while an oil channel (6) extends into the oil sump through said wall for communicating said two parts and comprises a gear-side end provided with a valve (7) for regulating the oil flow, controlled by the temperature of the oil, so as to close the oil passage in said oil pipe line (6) when the temperature reducing side oil reaches a predetermined temperature threshold.


Weather generators were useful for generating incomplete history weather records and weather scenarios in future.Recently they were used to study downscaling climate variables and provide weather forcings for hydrological and ecological simulations.Generalized linear models(GLM) are powerful tools for relating large-scale weather variables with high resolution variables at the earth surface.The application of generators based on GLM is promising.In this paper,by using five variables derived from single grid NCEP reanalysis data,such as air temperature,500-hPa geopotential height,potential temperature,relative humidity,sea-level pressure,as large-scale independent variables that affect precipitation variations,GLM for downscaling and simulating daily precipitation were constructed.For determination of precipitation occurrence probability,the logistic model was used,and for simulating daily precipitation amounts,the Gamma,exponential,normal,and lognormal distributions were used respectively.The observed daily precipitation series and the selected NCEP reanalysis data were used for parameter-estimation and simulation.The maximum likelihood estimate of the model parameters was performed by genetic algorithms.The results of estimation showed that the fitting effect of the gamma distribution-based models was the best,the lognormal distribution was the second,the exponential distribution was the third,and the fitting effect of the normal distribution-based models was the worst;on the other hand,the fitting effect of the models with their parameters estimated for each month separately was a little better than that without separation of months.Both the observed and simulated daily precipitation-occurrence probabilities were added for each month and the corresponding precipitation amounts were also averaged for each month in order to verify the models' ability.Results showed that the precipitation-occurrence probability was underestimated slightly by the logistic model,and precipitation-amounts expectations were underestimated by the exponential and gamma distribution-based GLM but were overestimated by the lognormal distribution-based GLM when monthly total precipitation amounts were large.The stochastic simulation of precipitation showed that the lognormal distribution-based GLM overestimated the yearly averaged monthly total precipitation and the exponential or gamma distribution-based GLM had a good simulation effect.On the whole,these stochastic models based on GLM and the NCEP reanalysis data are powerful tools for explaining and simulating the occurrence probability and amounts of precipitation.


The article deals with topical issues of regulating the freedom of movement of individuals as a component of the value system and the key right of citizens in the European Union. After all, freedom of movement itself includes a whole set of rights, which are both a guarantee of other natural rights and a sign of the rule of law. At the core of European values are liberal fundamental rights and freedoms, democratic principles of government, as well as the rule of law and social state. With the creation and development of the European Communities, the regulation of the right of nationals of Member States to move and reside freely has acquired not only national significance, but also a regional (cross–border) scale, which is an example for other integration entities. The European Union is trying to regulate the freedom of movement of individuals in a unified and at the same time as individualized way as possible. This is what is relevant for Ukraine in the context of European integration, because in Ukraine, some of the society has some fears over the loss of sovereignty through accession to the EU. Attention is drawn to the freedom of movement of all categories of EU and third–country nationals. Freedom of movement for individuals within the European Union covers the complex of rights of EU citizens, as well as their family members,
for free movement, residence, employment, economic activity and enjoyment of all social rights in each Member State of the European Union, regardless of their nationality. The specific features of the exercise of the right of free movement within the EU for Ukrainian citizens in the context of the Association Agreement with the EU and the Visa–free Agreement between the EU and Ukraine are also identified. The provisions on working conditions apply only to citizens of Ukraine or EU Member States who work legally on the territory of the other party to the Agreement. The
Association Agreement is not about freedom of movement for workers.


We report on the development effort of a nanosecond-pulsed seeded optical parametric generator (OPG) for remote trace gas measurements. The seeded OPG output light is single frequency with high spectral purity and is widely tunable both at 1600nm and 3300nm with an optical-optical conversion efficiency of ~40%. We demonstrated simultaneous tuning over the methane (CH4) absorption line at idler wavelength, 3270.4nm, and carbon dioxide (CO2) absorption line at signal wavelength, 1578.2nm. In this paper, we will also discuss open-path atmospheric measurements with this newly developed laser source.


The preparation and ferroelectric properties of layered ferroelectric lead-doped strontium bismuth tantalate (SrBi2Ta2O9) were investigated. The formation of solid solutions of lead-doped SrBi2Ta2O9 was corroborated, in this study. Adding excess bismuth oxide in prepared specimens profoundly enhanced their sinterability. The degree of c-axis preferred orientation of the sintered ceramics decreased with an increase in the lead content of lead-doped SrBi2Ta2O9. The lead-doped specimens exhibited ferroelectric properties with well saturated P-E loops. Both the remanent polarization and dielectric constant increased with the doping amount of lead cations.


We describe all the fine group gradings, up to equivalence, on the Lie algebra $\mathfrak d_4$. This problem is equivalent to finding the maximal abelian diagonalizable subgroups of the automorphism group of $\mathfrak d_4$. We prove that there are fourteen by using two different viewpoints. The first approach is computational: we get a full description of the gradings by using a particular implementation of the automorphism group of the Dynkin diagram of $\mathfrak d_4$ and some algebraic groups stuff. The second approach, more qualitative, emphasizes some algebraic aspects, as triality, and it is mostly devoted to gradings involving the outer automorphisms of order three.


In the development of information technology, the rapid current, so the more easy for every person in getting information. Information can be obtained in various ways, especially for modification of car seat covers. Therefore, efforts Repair Car seat holster "USARITA" offers products such as materials and car seats are offered online as well as for ordering products.


��� My motivation for reviewing Edward M. White's Assigning, Responding, Evaluating: A Writing Teacher's Guide was admittedly selfish. Simply put, I wanted to spend more time with many of the questions it poses and arguments it forwards. How do I understand the function of assignment descriptions, student peer workshops, and class-generated response rubrics, for example, as interrelated teaching and learning opportunities? In what ways does my understanding of each of these translate into practice? And, most important, in what ways do (or don't) my classroom practices support the development of student writing? Ironically, because my scholarly interests and experi ences center on writing assessment and composition pedagogy, I am not the primary audience for the text, which is positioned as an introduction to the issues surrounding assigning, responding to, and evaluating writing. (It's those very same scholarly curiosities, of course, that spurred my interest in this book.) However, I found that the time I spent with Assigning, Responding, Evaluating and the many conversations, real and imagined, I've had as a result (conversations with White; my students past, present, and future; other compositionists; and those internal dialogues with myself) have left me profoundly grateful as I found myself (as does White himself, since this is


Currently, many business people take advantage of technology by selling their products online to minimize the costs incurred for doing business through the marketplace. However, this does not reduce and affect the growth of the retail or offline store business. Thus, retail stores must build a good store atmosphere at affordable prices so that consumers make impulse purchases. This study aims to analyze the effect of store atmosphere and product prices on impulse buying at the Miniso offline store in Tunjungan Plaza Surabaya. This study uses a quantitative approach and uses multiple linear regression analysis techniques. The population in this study were Miniso consumers at Tunjungan Plaza Surabaya. The sampling technique used is a non-probability side with a purposive sampling type. Data collection through questionnaires was distributed to 100 respondents. The data were processed using SPSS 29. The conclusion from the results of this study showed that a partially stored atmosphere did not affect impulsive purchases (0,547 > 1,984 and a significance of 0,586 > 0,05). However, product prices have a partial effect on impulsive purchases (2,803 > 1,984 and 0,006 significantly<0.05). Simultaneously, store atmosphere and product prices affect impulse buying (8,073 > 3,090 and a significance of 0,001 <0,05).


Research on utilization the combination of taro leaves flour (Colocasia esculenta L. Schott) and soybean flour in artificial feed on the growth weight of carp fish (Osphronemus gourami L.) was conducted from February to April 2016. The aim of this research was to determine the percentage of utilization the combination of taro leaves four and soybean flour in artificial feed on the growth weight of carp fish. This research uses a completely randomized design (CRD) with 4 treatments and 3 replications. The treatment in this research was a combination of taro leaves flour in artificial feed about 0%, 5%, 10% and 15%. The results showed that the combination of taro leaves flour (Colocasia esculenta L. Schott) about (0, 5, 10 and 15%) with soybean flour in artificial feed formulation having the same effect (P>0,05) on the growth weight of carp fish.


On surface, Taiwan's successful political democratization seems to materialize at a price of economic downturn. However, this paper argues that after an initial negative relationship between democratization and economic development, Taiwan is likely to embrace both achievements. The major cause of the initial tradeoff between democratization and economic development was due to the incorrect strategic choices made by former President Lee Teng-hui that undermined both democracy and economic development. He inaugurated the vicious crony capitalism, composed of the state, the KMT, protected conglomerates, and local factions, in order to consolidate his presidential power. The presidential turnover of 2000 largely broke up the old crony capitalism. But continued democratic reforms are needed in order to prevent the emergence of new crony capitalism. This paper uses a case study of financial reform to elaborate these arguments.


The Ciliwung River receives loads from various sources of pollution along the border, both from agricultural waste, industrial waste, and domestic waste. The various wastes that enter the river cause a decrease in water quality. This study aims to determine the water quality status of the Ciliwung River in the Jakarta segment based on the Pollution Index (PI) and the Pesce-Wunderlin Water Quality Index (WQI). Monitoring on Ciliwung River water quality in the Jakarta segment was carried out in February-September 2021 at 18 observation stations. Most of the parameter tested for the water quality of the Ciliwung River in Jakarta does not meet the river water quality standards of class II based on Attachment VI of Government Regulation of the Republic of Indonesia Number 22 of 2021, such as total suspended solid, total dissolved solid, dissolved oxygen, ammonia, nitrite, total nitrogen, biochemical oxygen demand, chemical oxygen demand, total coliforms, and fecal coliforms. The water quality status of the Ciliwung River in the Jakarta segment is in medium to bad condition based on the Pesce-Wunderlin Water Quality Index and classified as moderately to extremely polluted based on the Pollution Index.


ABSTRACT The long-recognized disconnect between research and practice is reflected by social work students who often report significant apprehension about their research classes, likely at least in part because of a poor understanding of the research–practice interface and an unfamiliarity with larger professional social change initiatives like the Grand Challenges for Social Work. To counter this disconnect, this study showcases a successful model for BSW research courses that provides students with opportunities to engage in practice-informed research and research-informed practice through original, empirical, student-led, field-based research projects that are explicitly applied to the Grand Challenges. Drawing on student reflections, the study provides a useful exemplar of how a BSW research course can shape students' understanding of the role of research in practice that supports the even larger goal of contributing to the profession's impact on social problems and its role in social change.


The increasing competitive pressures from both global and domestic markets are forcing nations to adopt new trade practices and standards. Nations need to adjust to new methods of trade information exchange, open up their telecommunications systems and learn to take full advantage of harmonized procedures, standards, and practices for trade documentation. The role of electronic commerce and electronic data interchange (EDI) in particular, is rapidly evolving in the face of increasing pressure from global markets to provide standardized methods and practices for international trade.


Emission lines of krypton IV and V belonging to the 4s24pq-4s24pq-14d and 4s24pq-4s4pq+1 transition arrays are classified with the aid of a theoretical model developed for analogous Fe XII and Fe XIII transitions in a different atomic shell. Xenon VI lines are also identified. The observational material consisted of archived Zeta spectrograms.


Social media platforms archive the content and flow of social exchange across communication networks. This may present challenges for individuals because using these platforms increases the probability of observing exchanges among their friends in which they were unintentionally excluded. This study randomly assigned 194 participants to conditions where they were presented with written scenarios describing hypothetical online conversations between their close friends in which they were excluded or included. Results suggest that participants in the excluded condition experienced the most negative and least positive emotional responses. Further, participants with the tendency to devote cognitive resources to understanding their social networks—a construct we call network attention—were particularly sensitive to the stimuli. Network attention predicted negative emotional responses in the excluded condition and positive emotional responses in the included condition. Results are discussed in the context of communication and cognition via social media.


In semiconductor manufacturing, metrology is generally a high cost nonvalue-added operation that significantly impacts on cycle time. As such, reducing wafer metrology continues to be a major target in semiconductor manufacturing efficiency initiatives. A novel data-driven spatial dynamic sampling methodology is presented that minimizes the number of sites that need to be measured across a wafer surface while maintaining an acceptable level of wafer profile reconstruction accuracy. The methodology is based on analyzing historical metrology data using forward selection component analysis (FSCA) to determine, from a set of candidate wafer sites, the minimum set of sites that need to be monitored in order to reconstruct the full wafer profile using statistical regression techniques. Dynamic sampling is then implemented by clustering unmeasured sites in accordance with their similarity to the FSCA selected sites and temporally selecting a different sample from each cluster. In this way, the risk of not detecting previously unseen process behavior is mitigated. We demonstrate the efficacy of the proposed methodology using both simulation studies and metrology data from a semiconductor manufacturing process. Note to Practitioners—Here we consider a practical metrology problem encountered in semiconductor manufacturing, namely, design of a wafer measurement plan where measurements have to be taken from several sites across a wafer surface in order to monitor the accuracy and spatial consistency of a given processing step. A methodology is presented for designing a dynamic measurement plan for this scenario that minimizes the number of sites that need to be measured while maintaining an acceptable level of process visibility in terms of wafer profile reconstruction accuracy and the ability to detect previously unseen process behavior. Our approach can significantly reduce the number of sites that need to be measured on each wafer enabling greater throughput on metrology tools. While developed for wafer metrology in semiconductor manufacturing, the methodology can potentially be applied to the design of measurement plans for any surface whose variation exhibits strong spatial correlation.


Signature of the author__________________________________________________ Matthew Alan Totilo Department of Urban Studies and Planning 21 May 2009 Certifed by___________________________________________________________ Judith Tendler Professor of Political Economy, Department of Urban Studies and Planning Thesis Supervisor Accepted by__________________________________________________________ Joseph Ferreira, Jr. Professor and Chair, MCP Committee, Department of Urban Studies and Planning


This paper presents a development of a new biokinetic model for strontium, which accounts for age and gender differences of metabolism in humans. This model was developed based on the long-term follow-up of the residents living on the banks of the Techa River (Southern Urals, Russia) contaminated with Sr in 1950-1956. The new model uses the structure of ICRP model for strontium but model parameters have been estimated to account for age, gender and population differences in strontium retention and elimination. Estimates of ageand gender-specific model parameters were derived from (a) the results of long-term measurements of Sr-body burden for the Techa River population; (b) experimental studies of calcium and strontium metabolism in humans and (c) non-radiological data regarding bone metabolism (mineral content of the body, bone turnover, etc). As a result, the new model satisfactorily describes data on long-term retention of Sr in residents of the Techa River settlements of all ages and both genders and also data from studies during the period of global fallout in the UK and the USA and experimental data on strontium retention in humans. The new model can be used to calculate dose from Sr for the Techa River residents and also for other populations with similar parameters of skeletal maturation and involution.


List of Appendices - List of Acronyms - Acknowledgements - Introduction - Dreaming of a White Alliance, 1948-9 - Reluctantly to the Middle East, 1949-51 - The Cloak of Multilateralism, 1949-54 - The Churchill Factor, 1951-4 - The Simonstown Agreements, 1955 - Louw versus Erasmus, 1955-6 - The Hollowing of the Entente, 1957-60 - Conclusion - Appendices - Notes - Index


Samuel Beckett's radio play All That Fall presents an Ireland in which the traditional lines of sectarian division are unravelling. The blurring of difference that ensues is symptomatic of the curious state of suspension implied by the title of the play, which both suggests and withholds the promise that 'The Lord upholdeth all that fall'. This 'lingering dissolution' stabilises in a peculiarly indiminishable life force, reminiscent of Gilles Deleuze's notion of vitalism, which serves to reveal the unifying singularity underlying all distinct identities. However, while the play points out the illusory origin of sectarian (as other) division, it also acknowledges that such division will always, inevitably arise.


During the struggle for Lithuania's independence, defence and guerrilla units started forming inthe countryside, and fought against the Bermontian and Soviet forces and gangs of marauders.In 1919, intellectuals and public servants from Kaunas formed a sports-military guerrilla organisation,and called it the Lithuanian Riflemen's Union (LRU). The organisation accepted not onlynew members, but also people who had already fought with guerrilla units in northeast Lithuania.Therefore, the ranks of the LRU grew rapidly, and the new paramilitary organisation playedan important role in the struggle for Lithuania's statehood. The LRU was active throughout theinterwar period, until 11 July 1940, when, after the Soviet occupation, it was officially disbanded.This paper deals with issues of the scope and structure of the LRU, which until now havehardly been dealt with in historiography. The paper has three objectives: 1) it tries to establishchanges in the numbers of riflemen in the interwar period, as well as the numbers of peoplewho belonged to the LRU in different periods, and their total number throughout the interwarperiod; 2) the ethnic, religious and social composition of the Riflemen's Union is analysed, withthe aim of developing 'a social portrait of a rifleman'; and 3) the internal structure of the Unionis addressed: the numbers of reserve and combatant riflemen. Key words: paramilitarism, Lithuanian Riflemen's Union, paramilitary organisational structure,social composition, ethnic composition. DOI: http://dx.doi.org/ 10.15181/ahuk.v28i0.923


ABSTRACT Current research has demonstrated that the adsorption capacity of raw kaolin is considerably low. Advances in kaolin activation for enhanced utility and improved adsoptibility of pollutants include thermal treatment, acidification, or combined treatment. In this work activation of South African kaolinite with sulfuric acid and calcination is studied. Comparing the FTIR spectra of the activated kaolin i.e thermochemical treated kaolin (HAK) and thermal treated kaolin (HK) with raw kaolin the following main observation were noted; the bands attributable to Si-O stretching vibration (1023 and 1095 cm−1) increased in intensity by 61 and 59% for HK and HAK, respectively. Increasing the humic acid (HA) concentration (0.5–20 mg/L) increased the HA uptake for both adsorbents, HK increased from 0.52 to 0.75 mg/g while HAK increased from 0.59 to 0.86 mg/g. The adsorption of HA was delineated better by a pseudo-second-order model in both cases (Qe = 0.810; 0.793 mg/g for HK and HAK, respectively). From the synchronous spectra, two auto peaks were observed at (1650;1650) and (3246;3246) indicating concurrent and similar HA adsorption behavior on either of the adsorbents. From the results, it can be concluded that activation of kaolin improved its adsoptibility capacity for HA.


Bioethics as a field has Is shown an aversion, or at least reluctance, to asking substantive Justice questions about the human good or the ends of medicine. Enough? It has been prone to adopt formalistic criteria, on the one hand-essentially empty of content-or procedural criteria, on the other. It has in that respect deferred all too quickly to the supposed demands of pluralism, and the no less supposed resistance of postmodern intellectuals to tolerate any fraternizing with goals and ends of any kind. Yet unless there can be a discussion of the goals of medicine in the future as rich as that of justice and health care has been, the latter problem will simply not admit of any meaningful solution. We can settle for a purely procedural and political solution, but we do not have to. *


An autonomous monitoring and control system of unmanned surface vehicle (USV) with mobile water quality monitoring, sampling, and oxygenation functions is constructed. The control hardware and monitoring configuration software of the system is designed, respectively, which can be installed on USV and its remote control and monitoring terminal. The kinematic modeling of USV, waypoint trajectory-tracking control, distributed controller, simulation of tracking control, and verification of software and hardware design are carried out. In order to reject the system noise and external noise, a states estimation method with fully observable states is considered in the control law design. The software and hardware are also implemented to verify the effectiveness of the monitoring platform. Through setting a series of monitoring target points and monitoring parameters in the configuration software of the remote user terminal or in the APP of the mobile user terminal, the USV can realize the automatic cruise monitoring using an autonomous navigation and tracking control algorithm, and quantitative water sampling collection. The reliability of the system is verified by the experiment of the shore test station, and the waypoint trajectory tracking and sensors data are replaying in a logview GUI of MOOS-Ivp and APP.


A (β-diketiminato)nickel(II) hydrazido(1–) complex [LtBuNi(η2-N2H3)], {1, LtBu = [HC(CtBuNC6H3{iPr}2)2]–} has been obtained by treatment of [LtBuNiBr] with hydrazine. In a reaction of 1 with two equivalents of the azo compound diisopropyl azodicarboxylic ester (adc–OiPr) the Ni(N2H3) entity acts as both a hydrogenating and a reducing agent: diisopropyl hydrazidodicarboxylate (hdc–OiPr) is formed, and more adc–OiPr is reduced by two electrons. The resulting (adc–OiPr)2– is found as a ligand in the ultimate nickel product complex, the trinuclear nickel(II) compound [LtBuNi(μ-adc–OiPr)Ni(μ-adc–OiPr)NiLtBu] (2), in which two LtBuNi+ units are linked by a [NiII(adc–OiPr)2]2– moiety. The hypothesis that LtBuNiI species are acting as intermediates was supported by the independent finding that 2 can also be obtained by reaction of [LtBuNi(OEt2)] with adc–OiPr.


The present project is destined for the school "El Mundo de Bam Bam", which uses a manual method in its business process, using tools of the office package for the registration and qualifications where the information is not stored in a computer system for its later revision in an agile way in the case that merits it, it is only in a physical file. For the aforementioned, it was offered the realization of a web application that allows the registration of students, their registration and the entry of grades, helping the school staff to perform their usual administrative tasks more easily.


Summary form only given. Adaptive optics remove distortions caused by atmospheric turbulence by making corrections to the incoming wave front using one or more bright points of light in the area being observed as references. The use of multi-conjugate adaptive optics with multiple reference points can provide three-dimensional imaging of the regional turbulence. The required reference points can be artificial light sources created by shooting multiple lasers at the sky to excite mesospheric sodium atoms located 90 kilometers above the ground. Laser systems for adaptive optics need to be precisely tuned to the sodium D/sub 2/ transition (589 nm) and are unusually powerful (7-24 W) for lasers at this wavelength. The current state-of-the-art laser guide star (LGS) systems consist of either complex sum-frequency generation lasers or multiple-laser-pumped dye lasers based on the technology developed for the AVLIS Program at LLNL.


The lead-lag structure among time-series factors is the recognition that in multivariate time-series frameworks, some factor clusters significantly drive improvements in the framework, while various factors follow this development with time lags arises from. In this article, we propose a multivariate framework for the identification of lead-lag bundles in time series. We demonstrate that pairwise lead-lag interactions between time series can be viewed as a directed organization. There is a practical calculation for locating the lead-lag bundle set with significant pairwise imbalance in this instance. We investigate various options for the system's directed network clustering models and pairwise lead lag metric. Daily cost data on actual US values and the constructed generative model of the multivariate lead-lag time series framework are used to test the system. Using the pairwise lead-lag metric and directed tissue clustering computations, we offer a method for identifying lead-lag clusters in multivariate time series without a doubt. We demonstrate that the stationary tissue of pairwise lead-lag interactions between time series can be conceptualized as a directed tissue and that a suitable computation exists for locating the lead-lag groups in this type of tissue that have significant pairwise imbalances. increase.


Should college require health insurance for all students? This issue involves financial and ethical issues. This article raises questions for leaders to consider.


Theinvestigationsintothespatialandtemporaldistribution ofphytoplanktonicspeciesandthe change of community structuresin the Hangu multiple cellstabilization ponds were carried out during 1995 1997.Waterqualityofponds wasassesedbystudyingthealgalcommunitiesqualitativelyandquanti tatively.Theresultsshowedthatthevariationinalgalcommunitystructures wasstronglyrelatedto water qualityinthe differentgradesofpond.Sixsamplingstationsfrom firstpond(input) tolastone(output) weredistinguishableintermsofshowing differenceinthespeciesrichness,individualabundance and di versityindex andthelike.Firstpond withthe highestconcentration of COD,BOD5 ,Nand Pas wellas otherpollutants wasfound thatthere was afew species richness and low diversityindex in comparison with otherponds. Waterqualityinthelastpond(alsoasan ecologicalpond) wasobviouslyimproved due totheself purification andthis wasshown by dramaticincreaseinthenumberofspeciesand diversityin dexas wellas greatdecreaseinthetolerantpopulation'squantity.Averagely,alagalcommunity parame tersintheecologicalpond (lastpond) changed withthefollowingranges:56 speciesofalgal,1 .42 value ofdiversityindex and 41155.6×104/Lofindividualquantity.Thenumberofalgalspecies was wellcor related withtheconcentrationsof SS,BOD5 ,COD,NH3 Nand PO4 Pin the water.Thealgalquantity could beexpressed bysuch equationaslog Y= a+ bX- cX2 .


Within the ENIAC project "IMPROVE", new algorithms for virtual metrology and predictive maintenance are being developed to substantially enhance efficiency in European semiconductor manufacturing. The consortium comprises important IC manufacturers in Europe, solution providers, and research institutions. A major objective of the project is to make these new APC methods applicable in the existing fab systems of the IC manufacturers which widely differ in the automation infrastructure. A novel framework architecture for integration of the new control paradigms was researched and a software for implementation of the framework was developed. This paper describes the technical details and results of the framework development, implementation, and test.


In this paper, we characterize the worst-case interference for a finite-area TV white space heterogeneous network using the tools of stochastic geometry. We derive closed-form expressions on the probability distribution function (PDF) and an average value of the aggregate interference for various values of path loss exponent under Rayleigh fading channel. The proposed characterization of the interference is simple and can be used in improving the spectrum access techniques. Using the derived PDF, we demonstrate the performance gain in the spectrum detection of an eigenvalue-based detector for cognitive radio networks.


A method and an apparatus for transceiving signals in a communication system are provided to enable each user to select an optimum base station communication service mode by adaptively operating plural wireless access techniques optimized to plural communication service modes, thereby providing a terminal with association of ABS(Always Best Serviced)-ABC(Always Best Connected). A base station(400) comprises a reference signal generator(405), a broadcasting channel information generator(410), a transmission time controller(415) and a physical channel mapping unit(420). The reference signal generator respectively generates reference signals by an anchor service mode and a communication mode capable of being provided by the base station, and transmits the generated reference signals to the physical channel mapping unit. The broadcasting channel information generator generates broadcasting channel information to be transmitted to the physical channel mapping unit. The transmission time controller controls timing of the physical channel mapping unit to transmit the reference signal and the broadcasting channel information to a corresponding terminal. The physical channel mapping unit multiplexes the reference signal and the broadcasting channel information in an idle period by a communication service mode according to control of the transmission time controller. Therefore, the physical channel mapping unit configures a transmitting signal.


Background: The global COVID-19 pandemic has had a significant impact on all aspects of daily life. One area it has impacted on is psychological stress experienced by health workers, particularly sleep disorders.  The development of sleep disorders such as insomnia may affect the wellbeing of health care workers. This literature review aims to summarize the evidence concerning insomnia during the COVID-19 pandemic and its relationship to psychological distress in healthcare workers and to detect associates stress symptoms with sleep quality in health workers.
Methods: This study is a literature review constructed by searching articles through the Pubmed and Science Direct electronic databases using a combination of keywords, including articles published from 2020-2022, analyzing the effect of insomnia during the COVID-19 pandemic and its relationship with psychological stress. The review process used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) as a guide.
Results: A total of five articles were analyzed. Three studies indicated that insomnia was associated with stress symptoms even with low exposure to COVID-19 patient care. Two other articles showed that psychological distress has a negative impact on sleep quality to such a level that it interferes with daily activities.
Conclusion: Sleep disorders, including insomnia, are related to psychological distress in health workers in the COVID-19 pandemic era. Providing social and psychological support to health workers is crucial because the emotional well-being of health workers affects the quality of patient care, and subsequently the effective functioning of health services.


Recently, polymeric carbon nitride (nominally, g-C3N4) has attracted extensive attention due to its photoresponsive applications such as photocatalysis, photoluminescence, and photoelectrochemistry. Due to unique compositions and structures, strong excitonic effects of g-C3N4 network derived from low dielectric property have led to complicated photophysical processes. Studying exciton-related photophysical processes in g-C3N4 is of great significance for gaining in-depth understandings of the relationship between excitonic effects and photoresponsive behaviors. In this Perspective, we highlight the impacts of excitonic effects on photophysical processes of g-C3N4, in which excitonic behaviors like excitation, recombination, nonradiative relaxation, and annihilation are summed up. In addition, the key role of excitonic regulation in optimizing photoresponsive properties of g-C3N4 is also summarized, where the relevance between different photoinduced species and structural factors is emphasized. This Perspective will present a comprehensive understanding of excitonic effects-dominated photophysical processes of g-C3N4 and pave a new way for the design of novel photoresponsive polymeric semiconductors with strong excitonic effects.


Biogas is produced when organic matter breaks down anaerobically. This study reports a pilot project on the possibility of producing biogas from a mixture of water hyacinth and fresh rumen residue. The batch process bio-digester of installation capacity 7,500ml was designed and constructed for use in the study. The work also investigated the effect of reaction time and kinetics of biogas production. The results show that biogas production actually began on the 9 th day of production with a yield of 2.0ml and then the yield increased continuously up to the 17 th day with an optimal yield of 16.4ml. Thereafter, the yield of biogas decreased for the remaining production period. The total volume of biogas produced after 39days was 310.6ml, or approximately a mean yield of 7.9ml/day. Furthermore, the data obtained indicated that the bio-gas production reaction kinetics was second order and had an average specific rate constant of 0.02878 ml -1 day -1 . Water hyacinth has a


This experiment was carried out in the shade of the green network of the Department of Horticulture and Landscape, College of Agriculture and Forestry, University of Mosul, for the period from Apr. 11, 2019 to Sept. 30, 2019, with the aim of producing corm and cormlets in the summer of three varieties of Gladiolus X hortulanus L. They are: "Break of dawn" White flowers, "Espresso" with red flowers, and "Blue frost" with purple flowers after being treated with salicylic acid (SA) at 0 and 250 mg.l -1 , as well as treatment with calcium chloride in three concentrations: 0, 500 and 1000 mg.l -1 by spraying them on the foliage twice. The Factorial Experiment conducted by RCBD. The results show that the red cultivar recorded the largest weight of the corm was 28.98 g, its volume was 34.01 cm 3 , its diameter was 4.94 cm, and the number of cormlets was 12.33. per plant, the size of the cormlets is 13.52 cm 3 . Spraying with salicylic acid at 250 mg.l -1 had a significant effect in recording the largest values for the corm diameter and their volume. Treatment with calcium chloride at both concentrations 500 and 1000 mg.l -1 resulted in a significant increase in the corm weight, its diameter and the volume of cormlets. The treatment with calcium chloride at 1000 mg.l -1 caused to record the largest values for the number of cormlets are 9.53 cormlet. pl -1 , while the treatment with calcium chloride at 500 mg.l -1 increased of the corm volume is 27.68 cm 3 . The red cultivar plants treated with or without salicylic acid interact with calcium chloride at 500 mg.l -1 was gave the best grade of corms ranked 7.00 (Jumbo).


"The Multisectoral Framework 2002: new rules on regional aid to large investment projects"* 1. Introduction The Multisectoral Framework (MSF from now onwards) was adopted in 2002 and modified…


Abstract Recent studies in several laboratories have shown that some thicknessdependent physical properties of a-Si : H may be modelled on a thin, constant-thickness surface layer adjoining a variable-thickness bulk layer. Water permeation, Auger electron spectroscopy and elastic-recoil detection results from our laboratory all point to contamination of the a-Si : H surface as a source of the thin layer.


The invention provides a thermoplastic elastomer blend for a rubber plug of a vacuum blood collection tube, and a preparation method of the thermoplastic elastomer blend, and belongs to the technical field of high polymer materials. The thermoplastic elastomer solves the problems that that chipping falling during puncturing occurs when the existing thermoplastic elastomer material is used for the rubber plug of the vacuum blood collection tube, and the negative pressure resistance is poor. The blend comprises the following components in parts by weight: 100 parts of thermoplastic elastomer, 10-40 parts of filling, 20-100 parts of filler, and 1-5 parts of colorant, wherein the thermoplastic elastomer comprises a styryl elastomer, a polyolefin elastomer or a polyester elastomer. The invention further provides a preparation method of the thermoplastic elastomer blend for the rubber plug of the vacuum blood collection tube. The plastic elastomer blend has good negative pressure resistance when used for the rubber plug of the vacuum blood collection tube.


The present study investigates the adsorption and dissociation reaction pathways of boric acid, B(OH)3, and the reaction kinetic descriptors on NiO(001) and ZrO2(111) surfaces. Density functional theory is employed for ground-state calculations, while the nudged elastic band method is used for obtaining reaction barriers. Strong electron correlations in the case of NiO are included using the DFT + U approach. Adsorption of boric acid on clean ZrO2(111) is found to be more favorable compared with that on NiO(001), in agreement with prior experiments. Dissociative adsorption is observed to dominate over molecular adsorption in the case of ZrO2(111), whereas NiO(001) favors molecular adsorption. The most stable configuration for B(OH)3 on NiO(001) is a hydrogen-bonded molecular structure, Nis-(OH)B(OH)(OH)···Os (s = surface atom), with an adsorption energy of −0.74 eV. On ZrO2(111), a single O–H dissociated structure, Zrs-(O)B(OH)(HO)-Zrs + Os-H, with an adsorption energy of −1.61 eV, is the most stable....


The 3D spatial objects related to 3D geographic information systems are defined, and 3D vector data model and structure are put forward to represent the 3D spatial objects. Meanwhile, the topologic relations of the 3D data structures are analyzed and the data structures of the spatial objects are formally described.


Purpose: Anticoagulants are an important group of drugs used by many patients with different diseases. There are general adherence scales that measure adherence to treatment in the literature. However, the correct use of the drug alone is not sufficient for adherence with warfarin therapy. To develop Anticoagulant Therapy Adherence Scale for use in patients on
warfarin and to examine psycholinguistic and psychometric properties.
Methods: The research was of a methodological and consisted of 170 patients. The validity of the scale was tested by using content validity, explanatory and confirmatory
factor analysis. The reliability of the scale was examined by utilizing item-total scale
correlations and Cronbach's alpha.
Results: After the scale items were created, opinions were received from twenty
experts and content validity indexes were found to be above 0.80. In the explanatory
factor analysis, a 3-factor structure with factor loads between 0.30 and 0.81 was
obtained. Fit indices obtained in the confirmatory factor analysis were as follows: χ2 =
181.116, df = 116 χ2/df value 1.561, Root Mean Square Error of Approximation
(RMSEA) = 0.058, Comparative Fit Index (CFI): 0.88 and Goodness Fit Index (GFI):
0.88. Item-total scale correlation coefficients were found to range between 0.57 and
0.25. The Cronbach's alpha reliability coefficient was 0.74 for the overall scale and
0.63, 0.77 and 0.65 for its subscales.
Conclusions: ATAS was found to be a valid and reliable measurement tool in Turkish population. The scale can be used by healthcare professionals to evaluate patients' use of warfarin in a standard way.


The Tax Relief Act of 2003 allows one-half of the cost of most equipment to be deducted immediately. Bonus depreciation is irresponsible, Professor Johnson argues, because it generates a negative tax for debt-financed investments that is like the government paying for 27 percent of the cost of privately held equipment. The negative tax is both expensive and does harm, he says. Under the assumptions of Johnson's model, investments in equipment that returns only 70 percent of the prevailing fair market value interest rates can go forward. That will mean, Johnson says, that inferior investments will outbid better investments and waste precious capital. Wasting capital, he claims, will choke potential growth and destroy jobs. Johnson argues that bonus depreciation must have passed because of the carnival atmosphere.


e14014Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with high propensity of brain metastases (BM). Outcomes after upfront stereotactic radiosurgery (SRS) for BM from TNB...


Background: Higher blood pressure and albuminuria are found in offspring of mothers who smoke during pregnancy. Whether or not kidney development is affected by maternal smoking is unknown. Methods: Sprague-Dawley rats were randomly allocated to twice-daily cigarettesmoke and nicotine condensate (1 mg/kg) or vehicle at day 10 of pregnancy until delivery. Results: Exposed offspring did not differ from control offspring with respect to body weight, kidney weight, albuminuria, and creatinine clearance. Both male and female offspring had higher tail-plethysmographic blood pressures and lower mean glomerular volume, podocyte, mesangial-cell, and endothelial-cell number, compared to control offspring. Conclusions: The data document that prenatal exposure to cigarette-smoke condensate containing nicotine influences normal kidney development and could predispose to higher blood pressures later in life.


Crystals of 4-amino-2,2,5,5-tetrakis(trifluoromethyl)-3-imidazoline, C7NaFj2H3, are monoclinic, space group C2/c, with a=24.812 (24), b=6.598 (8), c= 16.076 (18)A, and fl= 118.51 (4) °. The data were collected on a diffractometer at room temperature; structure parameters were refined by least-squares methods to R of 0.067 for 1716 reflections. The molecule has no space-group imposed symmetry, but nearly has C~(m) point symmetry, the mirror plane being the plane of the imidazoline ring. Molecules are associated to form dimers through N H . . . N hydrogen bonds involving amino hydrogens and the unprotonated imidazoline nitrogens of adjacent molecules. A short external C-NH2 distance of 1.315 (4) A indicates a substantial resonance contribution from a ~ C = N ÷ H2 form.


Frequency-Domain Finite Difference(FDFD) model of ship casing walls is developed, and the frequency thermal characteristics of the structure in frequency domain are obtained. Meanwhile, CFD model of this structure(time-domain model) is also developed for the performance prediction of this structure. The FDFD model is validated by using the performance prediction of the CFD model of this structure. Based the FDFD model, the frequency thermal characteristics of this structure are calculated and analyzed. The results show that the dynamic characteristics of the structure in high frequency region should be considered and the heat flow can't be calculated by steady methods.


The study aimed to investigate the current status of reproductive concerns and explore the associated factors among young female chronic kidney disease (CKD) patients.


Robust stabilization of a class of linear neutral systems with nonlinear perturbation is discussed in this paper. On condition that the nonlinear uncertain functions are bounded, we first derive a sufficient condition for robust stability independent of delay. And then, we provide sufficient conditions for designing a memoryless state-feedback controller which stabilizes the uncertain neutral system.


Deep-learning-based algorithms successfully improve the detection accuracy of traffic lanes. Most of them employed stacked convolutional neural networks (CNNs) to extract semantics, but they have trouble gathering global visual information. What is more, the stacked CNNs perform multiple downsampling, which reduces the resolution of feature map, causing the tiny features easy to be ignored. To address these problems, LaneTD is proposed: a novel lane feature aggregator that extracts and fuses local and global features. This method adopts dilated convolution to extract local features of various scales and enhances global representation based on the transformer encoder. The local information and global information are then weighted fused using a bidirectional feature pyramid. In addition, we apply unsupervised image style transfer to improve the performance in nighttime and dark scenarios. The method is quantitatively evaluated on the public challenging CULane dataset, and the result shows that the proposed method significantly improves the accuracy and computational efficiency of lane detection in different scenarios. Furthermore, an ablation study is carried out, and a discussion of efficiency tradeoff choices can be applied in practice.


The exhaust gases emitted from automobiles are one of the major sources of pollution in urban centers. Big efforts have been made to meet the strict regulations they are subjected to. However, further development of the automotive engine is necessary to meet future challenges. Recently, thermography has proved to be a powerful tool to deepen the knowledge about the chemical and physical processes that take place in automotive engine. 2D infrared (IR) chemiluminescence measurements have been performed in an optical Common Rail diesel engine in order to investigate the different processes that regulate the pollutant emission formation. The time evolution of the injected fuel, of the flames, and of the burned gases has been analyzed. Infrared images have been detected in the spectrum from 1.5 μm to 5 μm. IR imaging has allowed obtaining more information with respect to the visible imaging. In particular, it has been possible to detect the fuel vapor and the burned gas motion in the combustion chamber for a longer period with respect to visible range. Moreover, two band-pass filters have been used. One filter is at 3.9 μm, a wavelength where liquid phase has high reflectance. Using this, it is possible to isolate the shape of the injected liquid fuel from the hot gases in the combustion chamber. The second filter is at 4.2 μm, it is the wavelength where carbon dioxide (CO2) emits. The mitigation of CO2 is mandatory by the European committee in order to improve the engine efficiency. CO2 evolution in the available volume during several combustion phases has been detected: the CO2 that enters during the aspiration phase, the spatial distribution of the CO2 that forms during the combustion phase, and, finally, the CO2 in the burned gases cloud that moves toward the exhaust valves. The results obtained suggest IR diagnostics as useful tool for engine control.


We report the synthesis and structure-activity relationship (SAR) of a large series of acridones and acridone-fragment derivatives designed on the basis of the selective antihepatitis C virus (HCV) activity shown by acridone 2, previously studied as a potential antibovine viral diarrhea virus (BVDV) compound. The evaluation of their ability to inhibit the HCV replication in Huh-5-2 cells led to the identification of new, selective inhibitors. This indicates that the acridone skeleton, when properly functionalized, is a suitable scaffold to obtain potential anti-HCV agents. Interestingly, during identification of possible cellular and viral targets, it was discovered that compound 23 exerts inhibitory activity on the HCV NS3 helicase, a very promising target for the development of anti-HCV drugs.


A new method for determination of formability limit in the tube drawing process was developed using the position controlled mandrel technique. In this method the mandrel has conical angle in a way that with change of mandrel position, the distance between die and mandrel will be changed and various combinations of thicknesses can be obtained using just one conic mandrel. The advantage of this method is determining the limit cross-sectional reduction for each tube dimension with just one experiment. The realized drawing limit tests on the aluminium tubes show that the average maximum area reduction of AA6063 tubes is about 40%. An optimal tube drawing schedule for production of the constant wall thickness aluminium tubes with high crosssectional reduction in one pass was successfully established based on the proposed formability limit test.


A new measuring method and device were proposed in this paper. It is about the cavity bubble system temperature control factor. It provides reference for research workers in this field. The method is applied in the passive atomic clocks technology, especially the integration filter resonance absorption cavity system temperature control technology.


The administration and funding of early childhood education programs has engendered recent federal policy debates. This volume is the third report in a series of three, which are derived from a study that examined how local organizations implement complex :sovernment programs for early childhood education. The study analyzed and documen'ed significant local examples of innovative and successful reforms in early childhood services, including Head Start grantees, local school districts, and child-care agencies. This volume describes the study's research design and methods, including the strategy for site selection and copies of interview guides used in the field work. The study focused on local examples of early childhood and family-support programs that were comprehensive, family-focused, sustained, and intensive. It included three different types of program strategies--parent-education programs, early child-care settings, and community-based partnerships. The research focused on program design, implementation, and impact, and looked at ways in which local, internal, and external forces shaped program development. All projects served children whose ages ranged from birth to 5 years and who came from families of low to moderate incomes. The projects involved sponsorship by one or more state or federal programs and included a significant component of outreach, involvement, and service to parents and other family members. Researchers conducted interviews with focus groups (administrators, parents, and s*aff) and with program directors. Attachments include a program-nomination form, copies of interview guides, and types of information coded for Ethnograph software. Two tables are included. (Contains seven references.) (LMI) U S DEPARTMENT OF EDUCATION Office f Educational Assam( H and ED ATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization cniginaling it D Minor changes have been made fo improve reproduction duality Points of view or oprmons slated In this document do not necessarily represent official OERI posifor or policy EARLY CHILDHOOD REFORM IN SEVEN COMMUNITIES: FRONT-LINE PRACTICE, AGENCY MANAGEMENT AND PUBLIC POLICY Volume Ill Technical Appendix: Research Design and Methodology


The compound SOP1812, a tetra-substituted naphthalene diimide (ND) derivative has been designed as a potent compound for targeting quadruplex sequences in cancer genes. It has been previously disclosed to have single-digit nM anti-proliferative activity in a panel of human cancer cell lines (Ahmed et al., ACS Med Chem Lett, 2020, 11, 1634-1644). It also has significant anti-tumor activity in several models for pancreatic cancer. We have also previously shown that two early-generation ND derivatives are active in both androgen-positive and negative prostate cancer cell lines (Mitchell et al, Biochemistry, 2013, 32, 1429-1436) and that these compounds down-regulate the transcription of quadruplex-containing genes such as c-MYC. We now report that this compound also shows significant anti-proliferative activity in several prostate cancer cell lines, notably with a GI50 value of 3 nM in the PC3 cell line. Abiraterone has a GI50 in this line of 4820 nM. By contrast SOP1812 has a GI50 of 247 nM in the LNCaP line, which is also derived from a patient with metastatic prostate cancer but is androgen positive. The PC3 line is derived from a metastatic carcinoma following androgen suppression therapy and is thus androgen independent and is a model for castration-resistant prostate cancer when hormone therapies are no longer effective. We have evaluated the activity of SOP1812 in the PC3 xenograft model using a twice-weekly 1 mg/kg dose regimen IV administered, against a saline control and abiraterone, at a daily dose of 200 mg/kg, administered by the PO route, both over a 28-day period. No weight loss was observed in treated animals with either drug. SOP1812 produced statistically significant tumor shrinkage (P value of 0.0008) relative to the controls, with a T/C value of 33.5% on day 28. Abiraterone treatment resulted in a T/C value of 61.6%, with a P value of 0.0382. SOP1812 is bio-available at therapeutic doses and is well tolerated at these levels in this animal model. It is currently being evaluated as a candidate for clinical development by Qualigen Therapeutics Inc.
 Citation Format: Nicole Williams, Jenny Worthington, Stephen Neidle, Ahmed Ahmed. The potent quadruplex-binding compound SOP1812 shows potent anti-proliferative activity in a prostate cancer cell panel and anti-tumor activity in an in vivo model of metastatic prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4068.


Effects of surface diffuseness parameter on quasi-elastic scattering have been studied using the nuclear potential Woods-Saxon (WS) for 6He+64Zn, 7Li+64Zn and 8Li+90Zr systems. The effect of rotational deformation was included for the nuclei 64Zn with ground state rotational band up to the 4+ states. We have been carried out the single (SC) and coupled-channels (CC) calculations to obtain the best compatibility between the notional accounts of dσqel/dσR with experimental data for systems studied. we find that the best fitted value of the diffuseness parameter which obtained through a coupledchannel calculation with inert target and excited projectile for In the current work, the singlechannel (SC) and the coupledchannels (CC) calculations, which were between the relative motion of the colliding nuclei and their intrinsic motions, were conducted to study its influence on calculation, the ratio of the quasi-elastic to the Rutherford cross sections and probe the surface diffuseness find that the best fitted value of the diffuseness parameter which obtained through a coupledchannel calculation with inert target and excited projectile for the 6He+64Zn, 7Li+64Zn and 8Li+90Zr.