The aim of this study was to recognize the most common uncertainties presented by patients diagnosed with Chronic Kidney Disease. Systematic review was made of the scientific literature of articles published between 2012 to 2018, in Spanish, Portuguese and English, and accessible to text full. Comprehensive and reproducible search of original works in the Scielo, PubMed, Ebschost, Dialnet, Redalyc databases, with the descriptors ( D e CS ) "Renal Insufficiency Chronic", "Theory of uncertainty", "Renal Dialysis" and their equivalents in Spanish, English, and Portuguese with critical assessment of the scientific quality of the studies applying PRISMA checklist (2009). The uncertainties were analyzed from the nursing theory of MIshel Merle, the findings show that the most common are related to ambi-guity and lack of information; Inference of the process, the inference is mostly presented and the confrontation of the disease is seen as a danger manifested with feelings of anxiety and depression


The success of theories, hydrodynamic models, recombination models, jet quenching and color glass condensate and so on brought us the fact that the strongly coupled quark-gluon plasma is created at RHIC. Now more detailed investigations from the theoretical side are carried out to know this hot and dense QCD matter at RHIC. I will give a brief overview on recent theoretical achievements for understanding of RHIC physics and also outline interesting topics which arise from recent experimental results and still await a theoretical explanation. I will discuss the expected future of the LHC physics from the point of view of exploration of the QCD phase diagram.


The effects of MAH in LDPE-g-MAH and the mass fraction of PA 6 on the mechanical properties of LDPE-g-MAH/PA 6 are investigated.The results show that the mechanical properties of LDPE-g-MAH/PA 6 are excellent when the mass fraction of PA 6 reaches 40% with two percents of MAH in LDPE-g-MAH.


Studies of endocrine disruption rarely examine changes in hormone receptors. Chronic exposure to a low dose of ingested petroleum caused an increase in corticosterone receptors in subcutaneous fat, a decrease in liver, and no change in kidney, muscle, spleen, or testis, suggesting significant changes in corticosterone signaling.


Introduction A large and growing number of patients with cancer have comorbid diabetes. Cancer and its treatment can adversely impact glycaemic management and control, and there is accumulating evidence that suboptimal glycaemic control during cancer treatment is a contributory driver of worse cancer-related outcomes in patients with comorbid diabetes. Little research has sought to understand, from the perspective of patients and clinicians, how and why different aspects of cancer care and diabetes care can complicate or facilitate each other, which is key to informing interventions to improve diabetes management during cancer treatments. This study aims to identify and elucidate barriers and enablers to effective diabetes management and control during cancer treatments, and potential intervention targets and strategies to address and harness these, respectively. Methods and analysis Qualitative interviews will be conducted with people with diabetes and comorbid cancer (n=30–40) and a range of clinicians (n=30–40) involved in caring for this patient group (eg, oncologists, diabetologists, specialist nurses, general practitioners). Semistructured interviews will examine participants' experiences of and perspectives on diabetes management and control during cancer treatments. Data will be analysed using framework analysis. Data collection and analysis will be informed by the Theoretical Domains Framework, and related Theory and Techniques Tool and Behaviour Change Wheel, to facilitate examination of a comprehensive range of barriers and enablers and support identification of pertinent and feasible intervention approaches. Study dates: January 2021–January 2023. Ethics and dissemination The study has approval from National Health Service (NHS) West Midlands—Edgbaston Research Ethics Committee. Findings will be presented to lay, clinical, academic and NHS and charity service–provider audiences via dissemination of written summaries and presentations, and published in peer-reviewed journals. Findings will be used to inform development and implementation of clinical, health services and patient-management intervention strategies to optimise diabetes management and control during cancer treatments.


Interaction requires dynamic relationship between objects. In ubiquitous computing environment, interaction between human and the environment is implied. Tactile interaction has so far been less addressed, while tactile sensation should be an important topic in the field of multimedia study. This paper describes development of a novel PVDF (Polyvinylidene Fluoride) dynamic tactile sensor and associated experiments. PVDF dynamic tactile sensors detect touch events applied to the sensor skin by low frequency components of the signal. Rubber skin-covered sensing material was mounted on the bones. Robust performance with low noise was figured out in our robotic experiment. Whereas most conventional sensors are interested in measurement, our dynamic tactile sensor is sensitive to change of state, which could be a key for economic understanding of happenings in the dynamic world. We note that dynamic sensing uses motion as a part of sensing modality We suggest that dynamic sensing be understood in technological terms in the perspective of interactive media and ubiquitous computing.


A fleet-level analysis of technology impacts on environmental metrics via generic vehicle design is proposed. Vehicles are grouped into "vehicle classes" distinguished by the vehicle-level environmental metrics, which include fuel burn (as a surrogate of CO2 emissions), NOx emissions, and SEL noise contours. These groupings are compared against traditional seat class groupings. Target metrics are established for a subset of 94 airports by designing a series of tests of sequentially increasing complexity, with ideal generic vehicle designs minimizing the error distributions across these airports when vehicle-level performance is aggregated to fleet-levels. Latin hypercube design of experiments are employed to explore the Environmental Design Space (EDS), and Stochastic Multicriteria Acceptability Analysis (SMAA) is used to evaluate potential generic vehicle designs against each other and identify the best designs for simultaneously matching aggregate fuel burn, NOx emissions, and DNL contours. In general, the average generic vehicles provide greater accuracy for each of these metrics across across the 94 airports for a representative six weeks of operations at these airports derived from various sources such as the Bureau of Transportation Statistics (BTS), as compared to the traditional approach of choosing a representative vehicle per class. The average generic vehicle approach works well for both vehicle-class and seat-class groupings, but the former leads to slightly tighter error distributions for all of the metrics.


Ordinary common litigation system in China will be one or both parties for two or more,the same type of litigation is the subject of litigation,the use of the same trial and sentencing procedures in order to save resources,improve the efficiency of judicial proceedings to avoid the courts of the same or similar the case of conflicting rulings.However,due to the lack of legislative law,in practice this system did not play a role。Author of Civil Procedure Lawof the existing common action on the general conditions applicable to the analysis of the system of proof that the parties should be the lifting of an ordinary common action against the defendant agreed to be subject to restrictions。Make the system not only because of the attitude of the defense decided to use the program and play a role.


A fault-alarm based hybrid controller design approach for Markovian jump system with actuator fault is investigated in this paper. By using linear matrix inequality (LMI) technology, both robust and reliable controllers are presented, which ensure that the normal systems and the fault systems are robustly stable. Then, in order to reduce the conservativeness of reliable controller design algorithm, a fault alarm-based switching method is given via choosing an adaptive threshold. Finally, an illustrative example is provided to demonstrate the effectiveness of the proposed method.


SPI‐62 is a selective and potent small‐molecule inhibitor of 11β‐hydroxysteroid dehydrogenase type 1 (HSD‐1). SPI‐62 has demonstrated substantial and complex nonlinear pharmacokinetics (PK) in humans that is characterized by unusually low plasma exposure at low doses, dose‐dependent volume of distribution, nonlinear PK following the first dose, and dose‐proportional PK at steady state, as well as unusually high accumulation ratios at low doses. The most likely explanation for the observed nonlinearity of SPI‐62 is the saturable binding of SPI‐62 to its pharmacological target HSD‐1, a phenomenon known as target‐mediated drug disposition (TMDD). Because of the nonlinear and complex PK of SPI‐62, the relationship among SPI‐62 dose, exposure, and response is no longer intuitive and consequently dose selection can be challenging. To facilitate dose selection and clinical trial design, in the current study population PK analysis was performed to characterize SPI‐62 dose‐exposure relationship in humans quantitatively. SPI‐62 PK was best characterized by a 2‐compartment TMDD model with 3 transit absorption compartments. The model was successfully established to explain the substantial and unusual nonlinear PK of SPI‐62 in humans, and it provided adequate fitting for both single‐ and multiple‐dose data. Our modeling work has provided a strong foundation for dose selection in future SPI‐62 clinical trials.


Aims: The influence of an antioxidant, propyl gallate (PG), on the in vitro antifungal activity of itraconazole and fluconazole, was investigated to determine whether PG could increase the antifungal activity and reduce strain resistance.


The Clark University research program in nuclear structure is a collaborative effort involving Clark University personnel, staff members from Brookhaven National Laboratory and an active participation of scientists from the US and other nations. The TRISTAN on-line isotope separator and the capture {gamma}-ray facility at the High Flux Beam Reactor are the primary experimental foci of the program which has four principal research themes, three involving nuclear structure physics and one directed towards astrophysics. These themes are: (1) the manifestation of the proton-neutron interaction in the evolution of nuclear structure and its relation to collectivity, (2) the appearance and the role of symmetries and supersymmetries in nuclei, (3) the study of new regions of magic nuclei, and (4) the characterization of nuclei important in r-process stellar nucleosynthesis.


This paper is a follow up study of [2]. In this paper we analyse the contents of middle school mathematics textbooks published in the 1st National Curriculum Period centered on the concept 'straight line' and discuss how they are different from contemporary mathematics textbooks in view of connectedness of contents, mathematical terms, textbook as a learning material vs. teaching material, relationship between contents of national curriculum and textbooks, and some topics related to direct proportion, function, method of equivalence as a method for solving simultaneous linear equations and so on. The results of our analysis and discussion suggest implications for reforming mathematics curriculum and developing mathematics textbooks.


Concentrations of sodium hydroxide, sulfuric and citric acids used in processing gelatin from cod skins affected both yield and quality. The highest yield of gelatin was obtained when low concentrations [0.1–0.2% (w/v)] of sulfuric acid and sodium hydroxide were applied to the skins followed by treatment with 0.7% (w/v) citric acid. The effects on bloom value, viscosity, odor, clarity, color and pH of the gelatin varied. However, the use of 0.7% (w/v) citric acid in different combinations with sodium hydroxide and sulfuric acid usually gave best results. Freezedried gelatin had considerably higher bloom value than air-dried gelatin.


Abstract : The trimodal random-field Ising model with the presence of a transverse field is investigated by introducing a parameter to simulate the fraction of spins not exposed to the external longitudinal magnetic field. Phase diagrams are obtained for different cases, and conditions for the occurrence of tricritical and reentrant phenomena are found.


POP ANCHORAGE DEVICE FOR RESTRAINING INTERMITTENT INSTRUMENT INSIDE A WELL BY APPLICATION MOBILE ANCHOR ARM AGAINST WALL THEREOF. ARMS ARE DISPLACED BY THE CYLINDER ENGINES OPERATED BY MEANS WITH MAINLY CYLINDER, PISTON SLIDE IN THIS tIGHT MANNER IN ACTION CYLINDER ENGINE AND PIPE HYDRAULIC FORWARD MOVEMENT PISTON CYLINDER AND MOVE TO ARMS. SYSTEM ANCHORAGE INCLUDES MEANS OF APPLICATION OF THE REIGNING PISTON PRESSURE WELL AND SECURITY SYSTEM TO LIMIT ARMS FORCES APPLIED TO MOBILE. APPLICATION TO ANCHOR IN SEISMIC SENSORS SURVEY HOLE FOR EXAMPLE.


a Airfoil of Turbine of Wind Ricardo Alvarez Cervera, Raúl Lesso Arroyo, Ramón Rodríguez Castro Instituto Tecnológico de Celaya, Tel. 52-461-611 75 75, Ext. 207, Fax. 52-461611 79 79, Celaya, Gto, México, e-mail: email@example.com, email@example.com Victor Lopez Garza Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich, México, Tel. 01 (443) 3 16 72 07, e-mail: firstname.lastname@example.com Abstract This paper shows software that makes the aerodynamic design of blades of a wind turbine. This software acts like interface using a program of simulation by finite element (ANSYS), which makes the aerodynamic airfoil analysis, applying the conditions of border and displaying the results in a stage of the post processing of the simulator. The interface also models the wind turbine blade, in order to make a 3D analysis to simulate the behaviour of the blade, to obtain: fluid-structural analysis, modal simulation and fluids analysis. The software considerably reduces the time destined to the aerodynamic design, modelled and airfoil analysis of blades. In addition it offers the opportunity to choose among a series of airfoils profiles that are commonly used in the design of blades of wind turbines. The obtained results were validated using numerical analysis; which showed satisfactory results. Software besides to be designed of tutorial form has a structure opened for future analysis of the structural type or fluids.


Background: Type 2 diabetes (2DM) represents one of most common diseases in the world and is the background for many other illnesses. Objective: To determine the Age Standardized Death Rate (ASDR) of illnesses bound to the condition of 2DM. Material and Methods: Among the 191 countries listed by WHO, the analysis was conducted in 49 countries (49 SC) with an approved registry. Eighteen among the most common illnesses, and 17 cancers were analyzed. ASDRs of 2000, 2010, and 2016 were correlated to 2DM. Results: Despite the population increase (+19.7 %), in 2016 Vs 2000 a significant reduction was shown for all ASDRs, with the exception of Alzheimer and pancreatic cancer in 2000. Positive correlations with 2DM was found for iron deficiency anemia (IDA), sexually transmitted diseases (STD), hemorrhagic stroke, respiratory diseases, chronic kidney diseases, prostatic and cervix cancers. Negative correlations were shown for pancreatic, throat/bronchus/lung (TBL), brain, bladder, kidney and melanoma cancers. For all the other illnesses no correlation was found. Conclusion: In case of 2DM, the most of CVD were under control, a part from hemorrhagic stroke. IDA, STD, respiratory and chronic kidney diseases, prostatic and cervix cancer should be addressed more carefully, while 2DM and the relative therapies seems protective towards pancreatic, TBL, brain, bladder, kidney and melanoma cancers.


The Physical Internet concept proposes a new way to move goods towards customers across a network of interconnected logistics services. According to this concept, the containerized goods travel form one hub to another until reaching their final destination. This principle implies that each container finds the best service on its route. The logistics service providers and then the carriers offer services (transport between hubs) accordingly. In this way, the allocation of a service to a provider becomes more dynamic and an efficient mechanism between offers and demands is required. We propose a combinatorial auction mechanism based on mechanism design theory to efficiently allocate bundles of containers to transport services. The hypotheses are described and the mechanism is divided into different processes called rules. The con-tribution of this work is based on the ability of the Physical Internet to reallocate a container to carrier at each hub if it improves the routing of the container and the utilization of the logistics network resources. An exam-ple illustrates how the proposed mechanism will work at the level of a single hub and how container bundles are allocated to carriers.


The social standardization and the relational points of view take as an initial stage that the current conditions of transitory work are socially characterized. The term cost often has many meanings; in accounting is the value of the resources given in exchange for an item or service, which may represent a disbursement of money or the acquisition of a commitment. The problem of this paper is the lack of importance of the role of the social media mechanism in improving the firm's sales. This paper has used a questionnaire survey to be the instrumentation for the study to collect the data from the sample. By applying the moderation effect test to find out the moderation impact on social media mechanism for the relationship between the product access availability, product cost, and sales improvement. The significant level for this relationship is 0.185 and the t-value is = 88.705.


Aim:To prepare the self-assembled nanoparticles based on carboxymethyl chitosan bearing long alkyl chains(Noctyl-O,N-carboxymethyl chitosan,OCC),characterize the physiochemical properties of OCC self-assembled nanoparticles and meanwhile evaluate the safety profile.Methods: OCC self-assembled nanoparticles were prepared by dia-lysis and characterized using dynamic light scattering,Zeta potential and transmission electron microscopy(TEM).The safety of OCC self-assembled nanoparticles was evaluated by in vitro hemolysis tests and acute toxicity in mice.Results: The mean size of self-assembled nanoparticles was 165.6 nm with polydisperse index of 0.191;The Zeta potential was-30.2 mV,which were attributed to the carboxymethyl groups on the surface of OCC self-assembled nanoparticles.The TEM images showed a spherical shape.The result of in vitro hemolysis tests showed that OCC self-assembled nanoparticles were safe carriers in terms of the induction of the membrane damage.The LD50 and its 95% confidence interval of OCC self-assembled nanoparticles in mice were 560.2(523.0~600.0) mg/kg.Conclusion: The present OCC self-assembled nanoparticles could be potentially useful as safety carriers for the intravenous drug delivery.


Background: Non specific low back pain (NSLBP) has been identified as one of the commonest rheumatic disorders in prevalence surveys in Asia-PacificObjective: Development of a core questionnaire for identification of risk factors of NSLBP at community level.Methods: Following steps were followed: 1) item generation from literature survey, existing Nordic questionnaires and patient focus group discussions, 2) development of a preliminary APLAR-COPCORD English questionnaire, 3) translation into target language, back translation and development of a synthetic target language version, 4) adaptation of the synthetic target language version through tests of comprehensibility, content validity test-retest reliability, and 5) finalization of the English questionnaire. .Results: 45 items were generated. A preliminary English questionnaire was developed.Conclusion: The developed English questionnaire will serve as an efficient tool for identification of risk factors of NSLBP in Asia-Pacific communities.TAJ 2011; 24(2): 85-90


This paper is aimed at correlation between desertification processes and soil physio-chemical properties.The results show that:(1) soil nutrient is characterized by richer-K,less-P and poorer-N in desertified land;(2) during sandy desertification processes,the regulation of soil degradation is close related to zonality,the decreasing trend of soil organic matter(SOM),available P and available K is western region middle region eastern region,the decreasing trend of total N is middle region eastern region western region,and that total salt content is middle region western region eastern region;(3) regionalized differences of available K,available P and total salt content are obvious,among which available K shows western region(228.8~81.4mg/kg) eastern region(62.5~32.5 mg/kg) middle region(40.1~19.2 mg/kg),available P shows eastern region(7.84~3.45 mg/kg) middle region(4.84~2.19 mg/kg) western region(2.73~0.72 mg/kg),total salt content shows western region (7.75~1.18 g/kg) middle region(0.57~0.08 g/kg) eastern region(0.10~0.04 g/kg),soil salt content has not significant correlation to sandy desertification,but close relation to water environment and human activities;(4) soil texture affected by sandy desertification shows eastern region middle region western region,in the western region,the decreasing rate of sand content is less than that in eastern and middle regions,that of silt content is more than two other regions,and that of clay content is less than eastern region but more than middle region;(5)the peak period of sand content increasing and silt and clay content decreasing in middle and eastern regions is earlier than that in western region,showing these two regions are affected earlier than western region,hence,sandy desertification in these two regions should be control as early as possible.


Current coastal operations have to deal with threats at short range in complex environments with both neutral and hostile targets. There is a need for fast identification, which is possible with a laser range profiler. A number of field trials have been conducted to validate the concept of identification with a laser range profile. A laser range profiler with a high bandwidth, fast laser receiver was used to perform tests on the capability of a laser range profiler for ship identification. Typical rise and fall times are 2 ns corresponding to a range resolution of 0.6 meter. The experimental profiles of the ships and simulated range profiles based on 3D target models show very good correspondence. It is shown that laser range profiles match closely the geometric structure of the ship. Furthermore, the good match between experimental and simulated laser range profiles means that a database of laser range signatures can be constructed from 3D-models, thus simplifying the database creation. Based on the experiments a system model was made for the range profiling of air targets. The validated system model shows that air targets can be identified at ranges of several tens of kilometers. An identification algorithm was used to distinguish three aircraft from their simulated range profile with good results.


Every organization uses an evaluation system in order to gather useful information as a guideline to improve products and services. The university is one of the organizations that need to use beneficial information from an evaluation system. In addition, to support the key performance indicator (KPI) of the university, the evaluation form should be generated with the questions that can measure the KPIs. Matching questions in the evaluation form with KPIs is still some of the problematic such that the answers cannot be used for assessing the performance based on KPIs. BeEvaluator was introduced and developed to provide a user-friendly evaluation system for generating an evaluation and suggesting questions that related to KPIs of the event via web-based system. BeEvaluator system also provides feature that requestor can edit and delete evaluation form. In addition, to create an effective evaluation form, it has to approve by the administrative team before the system generates the evaluation form. The benefits of this system are to reduce resources such as paper and time of collecting and analysing the data manually. The system will produce more accurate result in real time. Moreover, BeEvaluator system generates the QR code which will be scanned by evaluator in order to evaluate the evaluation form. This will allow evaluator to access the form conveniently anywhere on their mobile phones.


Introduction: Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic premalignant plasma cell dyscrasia that occurs in 3-5% of patients above the age of 50. In addition to its known progression to multiple myeloma (MM), MGUS is associated with higher risks of second malignancies. The progression from MGUS to more advanced diseases has a significant impact on overall survival. This systematic review and meta-analysis therefore aimed to comprehensively evaluate the incidence of malignant progression and the development of second malignancies in patients with MGUS.
 Methods: The protocol of our study was registered in PROSPERO with ID(CRD42018092067). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a comprehensive electronic search in nine electronic databases, including PubMed, Google Scholar, POPLINE, WHO health library, System for Information on Grey Literature in Europe, Scopus, Web of Science, Virtual Health Library, and The New York Academy of Medicine. The following predetermined search terms were used: (monoclonal gammopathy of undetermined significance or MGUS); (incidence or progression or transformation); (myeloma or lymphoma or amyloidosis or macroglobulinemia or leukemia or plasmacytoma or malignancy or malignant). Risk of bias was assessed using the National Institute of Health (NIH) study quality assessment tool. Random-effects model was used to synthesize the pooled event rates of MGUS progression and development of second malignancies. Statistical heterogeneity was evaluated using Cochran's Q statistics and I² tests, with p-value≤0.10 or I² value>50% considered as statistically significant. Sub-group analysis based on the duration of follow-up was conducted to obtain rates of progression in patients who were followed-up for 0-5 years, 5-10 years, and more than 10 years. Meta-regression based on age, gender, immunoglobulin subtype of MGUS, and publication year was performed to explore any statistically significant heterogeneity if there were more than 10 studies. Publication bias was assessed using Begg's funnel plot and Egger's regression test if the number of studies was more than 10.
 Results: A total of 4690 articles were identified. Of those, 315 articles were found eligible for full-text screening. We finally included 48 studies for analysis including a total of 20945 patients with a mean age of 64.1 years. The mean duration of follow-up was 7.43 (1.8-34.1) years. The overall cumulative rate of MGUS progression and development of second malignancies was 8.6% (95% CI, 7.2-10.2%). The rates stratified based on years of follow-up were 6.9% (95% CI, 5.3-8.9%) at 0-5 years, 8.8% (95% CI, 6.4-11.8%) at 5-10 years, and 14.9% (95% CI, 10.8-20.2%) beyond 10 years. Rates of progression to MM, Waldenstrom macroglobulinemia, and amyloidosis were 5.8% (95% CI, 4.7-7.2%), 2.1% (95% CI, 1.1-4.0%), and 0.7% (95% CI, 0.3-1.5%) respectively. The rates of development of non-Hodgkin lymphoma and leukemia were 2.5% (95% CI, 1.5-4.3%) and 1.4% (95% CI, 0.4-4.4%) respectively. The rate of development of solid tumors was 6.4% (95% CI, 2.5-15.4%). Meta-regression for evaluation of statistical heterogeneity was performed for most outcomes, except for those with less than 10 studies (leukemia, amyloidosis, solid tumors, and follow-up beyond 10 years). Age and publication year were the source of heterogeneity in most. Overall risk of progression does not vary with MGUS subtypes. There was no publication bias based on Begg's funnel plot and Egger's regression test.
 Conclusions: The risks of MGUS malignant progression and development of other hematological/solid malignancies remain significant, approximating 15% after 10 years of diagnosis. Future efforts could be directed toward better cancer surveillance and deferral of malignant progression among patients with MGUS.

 No relevant conflicts of interest to declare.


In this paper we provide a brief summary of development LivingLab PJAIT as an attempt to establish a comprehensive and sustainable ICT-based solution for empowerment of elderly communities towards better urban participation of seniors. We report on our various endeavors for better involvement and participation of older adults in urban life by lowering ICT barriers, encouraging social inclusion, intergenerational interaction, physical activity and engaging older adults in the process of development of ICT solutions. We report on a model and assumptions of the LivingLab PJAIT as well as a number of activities created and implemented for LivingLab participants: from ICT courses, both traditional and e-learning, through on-line crowdsourcing tasks, to blended activities of different forms and complexity. We also provide conclusions on the lessons learned in the process and some future plans, including solutions for better senior urban participation and citizen science.


The patient was a 38-year woman.Six years prior to presentation,she developed erythema and papules with occasional pruritus in both labium majora,which gradually confluenced into plaques with the formation of superficial erosion and ulcer;extension into the vulva and crissum occurred later.Half a year prior to presentation,a subcutaneous firm nodule measuring about 1.5cm in diameter with intact epidermis,developed on the right submaxilla,associated with mild swelling in the area;the nodule enlarged gradually.A subcutaneous induration measuring 0.5 cm in diameter was observed in the left chin 2 months later.She also reported a 20-year history of dry eye and dry mouth.The patient tested postive for antinuclear antibody cally,there was a focal infiltration of lymphocytes in tissue of minor salivary glands.The pathology of lesions on the right labium majus showed a dense dermal infiltration with S100-and CD1a-positive,irregulady-shaped histiocyte-like cells with abundant eosinophilic cytoplasm and few mitotic figures.Needle biopsy of the right submaxilla area showed tumor cells.A diagnosis of Langerhans cell histiocytosis and Sj(o)gren syndrome was made based on clinical manifestation,laboratory findings and histopathological features.Combination chemotherapy with cyclophosphamide,vincristine,corticosteroids and etoposide resulted in clinical improvement.

Key words:
Histiocytosis,Langerhans-cell; Sj(o)gren's syndrome


Rituximab (RTM) is considered as a promising therapeutic agent for treatment of With Interstitial Lung Disease (ILD) in the patients with systemic sclerosis (SSc). However, the limited number of RTM-treated patients, considerably varying dose regimens, cumulative doses and observation periods, lack of data on potential predictors of RTM therapy response do not allow univocal conclusions on RTM efficacy or definitive recommendations on RTM use in the patients with SSc.The study of potential efficacy predictors of anti-B-cell therapy in the patients with SSc associated with ILD.90 patients with SSc-ILD verified by multispiral computed tomography were enrolled to the study and received RTM therapy for 12-42 months at cumulative dose 2.9±1.1 grams (disease duration 5.9±4.8 years, diffused/limited SSc 1.3/1, average age 47 ± 13.6 years, females 83%). All patients received low or moderate dose glucocorticoids. 45 patients received RTM in addition to immunosuppressive therapy (cyclophosphamide and mycophenolate mofetil) because of inadequate efficacy of immunosuppressants. After evaluation of FVC trends in the patients receiving RTM the overall study population was divided into two patient groups for the analysis: group A (n=35) comprised the patients with ≥10% FVC increase (disease duration 6.1±5.8 years, diffused/limited SSc 1,3/1, average age 50±12 years, females 86%, cumulative RTM dose 3.2±1.24 grams), and group B (n=11) comprised the patients with ≥5% FVC decrease (disease duration 5.2±4, diffused/limited SSc 0.8/1, average age 43±16, females 72%, cumulative RTM dose 2.5±0.99 grams). Subsequently correlation analysis was made to clarify the association between delta FVC and a number of clinical (age, gender, duration and form of SSc, modified skin count, presence of gastroesophageal reflux, mPAP, SSc activity (EScSG, points), cumulative RTM dose, immunosuppressive therapy) and laboratory parameters (ESR, ANA-НЕР-2, a-Scl-70, CRP, B cell count).In the overall patient population RTM therapy was associated with significant FVC increase from 77.0±19.9 % to 84.7±20.9% (р=0.000000), with median FVC increment 6.6% [0;14.1].In group A FVC increased from 75.3±19.9 to 94.3±20.4) (р=0.000000), with median FVC increment 16.3 [12.6; 24.7].In group B FVC decreased from 82.5 ±23.2 to 72,3±19.4 (р=0,000176), with median FVC decrement 10.4% [-13.4; -6].Correlation analysis in groups A and B showed significant association of between delta FVC and the patient age (R=0.36), cumulative RTM dose (R=0.34) and EScSG during the last examination (1.2±.,0 and 3.1±1.4 in groups A and B, respectively; R=-0.42).No significant correlation between delta FVC and any other tested parameters was found.Therefore, older patients who received the cumulative rituximab dose more than 3 grams with suppressed SSc activity achieved greater FVC increase at the background of therapy. These data allow to consider the above parameters as potential predictors of response to anti-B-cell therapy in the patients with SSc-ILD.None declared


The real-time tracking of indoor locations for firefighters and trapped people is key information for the fire emergency command, especially in high-rise buildings or complex buildings. An enhanced iBeacon-based indoor positioning system is proposed in this paper to solve the indoor positioning problem for the fire emergency command. A fire emergency command platform is developed based on this iBeacon-based indoor positioning system. The key issues for the fire emergency command are solved in this platform, including tracking and visualization of the indoor and outdoor positioning for firefighters and trapped people and information sharing and synchronization among different systems such as the firemen handheld terminals, the command platforms in the command center and the mobile command platforms. The results show that the positional accuracy can reach approximately 3 meters. The iBeacon station used in this paper can operate for 3 years based on its battery life, which suggests that the developed platform can provide real-time indoor and outdoor positioning services and mapping services for the fire emergency command rescue after the fire occurs. Therefore, the fire commander can now determine whether there are firefighters who are trapped or lost in the fire by monitoring their real-time positions.


This report describes the development of a high-voltage connector at the request of Scandinova Systems AB in Uppsala. The development process is described from the making of a customer demand speci ...


N- unsubstituted, N- alkylated, or N- acylated 14-O - [(amino Emissions such, or, 14-O - [(amino The above compound, as appropriate, take the form of a salt and / or solvate. Moreover, pharmaceutical compositions comprising such compounds. Furthermore, the medical composition appropriately with other pharmaceutically active agent in combination with for example a microbial infection treatment and pharmaceuticals for treatment of acne, the use of the medical composition.


Foreword This survey is a product of the Quadrennial Defense Review (QDR) 2001 Working Group, a project of the Institute for National Strategic Studies at the National Defense University. Sponsored by the Chairman of the Joint Chiefs of Staff, the working group is an independent, honest-broker effort intended to build intellectual capital for the upcoming QDR. More specifically, it aims to frame issues, develop options, and provide insights for the Chairman, the services, and the next administration in three areas: defense strategy, criteria for sizing conventional forces, and force structure for 2005-2010. One of the group's initial tasks was to assess the future security environment to the year 2025. This was pursued by surveying the available literature to identify areas of consensus and debate. The goal was to conduct an assessment that would be far more comprehensive than any single research project or group effort could possibly produce. This survey documents major areas of agreement and disagreement across a range of studies completed since the last QDR in 1997. Because it distills a variety of sources and organizes and compares divergent views, this volume makes a unique contribution to the literature. It also provides a particularly strong set of insights and assumptions on which both strategists and force planners can draw in the next Quadrennial Defense Review. Michele A. Flournoy Project Director Introduction There was a legend in ancient Rome about a fabulous set of nine books which contained a predestined history of the Roman people and--in particular--details of all future wars and crises which would beset them. These oracles, the property of Amalthaea--the sibyl or prophetess of Cumae--were proffered to the Roman government. In a tale of greed, chauvinism, and intrigue worthy of a melodrama, the Romans decided not to pay the sibyl's price for the books and to bargain for a better deal. Upon learning of their decision, an angry and incredulous Amalthaea threw the first three books into a fire where they burnt to ashes. She thereupon asked for the exact same price for the remaining six books. Again the Romans, wanting a view of the future on the cheap, refused her price and made a lower offer. An angrier Amalthaea burned three more books, and again asked the same price for the last three. Now desperate, the Roman government acceded, and purchased what came to be known as the Sibylline Books. Because six books were destroyed, there could be no consensus among the Romans on interpreting the three surviving books. Despite sifting through the Sibylline ashes, they were unable to find the threads of meaning that could turn disconnected prophecies into a coherent view of the future. The books hinted that Rome would someday be a great power, dominating and bringing order to the known world. But the fragmented verses seemed to provide no basis for policy. Years later, a frustrated Caesar Augustus destroyed some 2,000 verses as spurious; they warned of things that seemed implausible or could not be understood. (1) Today, the United States is the dominant world power. We strain to bring what we understand to be order to an apparently chaotic world. Many dream of a future age of freedom, justice, and peace for all humanity. In the meanwhile, all of us wish to bequeath to our children a nation free from the threats and dangers that beset far-off lands and, potentially, our own: wars, poverty, oppressive ideologies, and ethnic hatreds. We want to know what particular dangers the future will bring. We want to be able to craft policies to protect and defend ourselves against those who would be our enemies, and, where possible, to bring peace to those whom we would aid. There is no sibyl to offer us a complete set of reliable predictions and thorough explanations of the future threats we will face. There is no predestined chronology or policy which we can follow like a road map. …


A novel symmetric weak formulation of Biot's equations for linear acoustic wave propagation in layered poroelastic media is presented. The primary variables used are the frame displacement, the acoustic pore pressure, the scalar potential and the vector potential obtained from a Helmholtz decomposition of the fluid displacement. Also a symmetric weak form based on the frame displacement, the pore pressure and the fluid displacement is obtained as an intermediate result. hp finite element simulations of a double leaf partition based on this new weak formulation is verified against simulation results from the classical frame displacement, fluid displacement formulation and a frame displacement pore pressure formulation. All three formulations simulated, displays the same rate of convergence with respect to finite element bases polynomial degree. The novel formulation also extends a previously published frame displacement, pore pressure, scalar fluid displacement potential formulation with an implicit irrotational fluid displacement assumption to a full representation of Biot's equations. Copyright © 2010 John Wiley & Sons, Ltd.


PurposeThis study aimed to identify the determinants of farmers' participation in agricultural information-sharing digital groups and their impacts on farm performance.Design/methodology/approachPrimary data of the 2015/2016 crop year collected from 175 cattle farmers were analyzed using descriptive statistics and econometric models. Farmers who had smartphones and participated in social groups/applications, especially those created to exchange agricultural information, were considered adopters of the technology.FindingsA Poisson hurdle model showed that farmers' decision to participate in agricultural information-sharing digital groups is determined by schooling, age (negative effect) and use of tools for planning production. The intensity of participation is affected by risk propensity, interaction with specialist advisors, use of tools for planning production and participation in cooperatives. The authors also found empirical evidence that farmers' participation in agricultural information-sharing digital groups positively affects farm income per hectare.Research limitations/implicationsThe results of this study are important for accelerating the diffusion of low-cost digital technologies, which are powerful tools for improving farmers' sharing and access to valuable information in real time and in locations far from urban areas.Originality/valueTo the best of the authors' knowledge, this is the first empirical analysis of the adoption and impacts of agricultural information-sharing digital groups/applications by Brazilian cattle farmers. The diffusion of simple digital technologies is important for reducing heterogeneity and increasing the efficiency of cattle production.


alloy steel, special steel, forged metal and non-ferrous metals. During the brake type pressure welding cycle, as indicated in Fig. 1a, frictional heat is generated by rubbing together the materials to be welded (a) and (b) whilst (a) is rotated under a constant friction pressure (P 1 ); in b the vicinity of the contact zone starts to undergo plastic deformation reaching to a high temperature by frictional heat; in c the rotation is suspended and an even higher upset pressure (P 2 ) is applied and the joining is completed. Currently, joining is feasible for joint diameters within the range of 3–200 mm (with carbon steel solid bar as the standard) using a commercially available friction welding machine. The friction welding conditions of friction pressure, upset pressure, rotational speed, friction time, upsetting time should be determined according to the materials, joint configuration (for example, solid bar and plate, pipe and solid bar, bars of dissimilar diameter, etc.) and dimensions. Up until recently, friction welding of dissimilar metals had been applied in many cases where expensive materials were employed for essential regions only and inexpensive materials were employed in other regions in order to save cost. However, more recently there are instances where all the individual functions of each component have been made into a composite body by means of friction welding and there are an increasing number of cases where friction welding of dissimilar metals is put to practical use as a Introduction


The invention discloses a distributed base station and a data processing method thereof, and relates to the technical field of wireless communication. The data processing method includes that: a forward signal is transmitted to a distributed node of the base station by a digital signal processing module of the base station; the forward signal is converted into a radio frequency signal by the distributed node; the radio frequency signal is sampled and processed by a feedback device of the base station to obtain a feedback signal, and the feedback signal is transmitted to a nonlinear distortion corrector by the feedback device of the base station; correction is carried out for the forward signal by the nonlinear distortion corrector according to the feedback signal to obtain a corrected forward signal, and the corrected forward signal is transmitted to the distributed node; and the corrected forward signal is converted into a radio frequency signal by the distributed node, and then sent to a user terminal. With the distributed base station and the data processing method thereof, problems of nonlinear distortion of the radio frequency units of a DAS of the base station and high computational complexity of the base station are solved. Beneficial effects of the distributed base station and the data processing method thereof are that influence of a nonlinear element to a distributed antenna system is decreased, and computational complexity of the base station is reduced.


According to the reported conservative sequences of Pinb gene,a pair of specific primers were designed to amplify,clone and sequence Pinb gene of DNA genome in Aegilops bicornis (SS) and a new allele of Pinb was found.The allele was 360 bp long,encoded 119 amino acid residuals,corresponded with the mature protein structure region of PinB in cereal crops, had its specific tryptophan motif of WPTKWWK and contained five disulphide bonds formed by ten cysteines.In nucleitide and amino acid sequences,it is 93.1% and 91.6% as homologous as Pinb-D1a of T.aestivum cv.Capitole,respectively.It was proved by RT-PCR that Pinb gene expressed itself in grain endosperm.The results indicated that Aegilops bicornis contained the gene regulating grain hardness that greatly differed from that in wheat so that it could provide rich genetic resources for wheat quality improvement.


A method of calculation of potential magnetic fields around cylindrical and toroidal flux ropes is presented. The flux rope has an arbitrary orientation with respect to ambient field. The problem is solved analytically. Expressions for the magnetic field components, diamagnetic force, and its moment are found. Results obtained can be used for estimations of magnetic forces in systems where magnetic flux ropes and potential fields coexist, e.g., in the solar corona.


A multi-group investigation was conducted at Hamburgische Schiffbau-Versuchsanstalt GmbH (HSVA) from Oct. 24 to Nov. 11, 2016 under the Hydralab+ Transnational Access project: Loads on Structure and Waves in Ice (LS-WICE). There are four parts to this investigation: wave attenuation/dispersion in broken ice covers, wave-induced ice-floe collisions, ice fracture under wave action, and ice-structure interaction under wave conditions. This paper focuses on the part of the experiment related to wave-induced ice breaking. During the preparatory stage of the tests, a continuous ice sheet was produced, and the mechanical and physical ice properties were determined at a number of selected locations in the Large Ice Model Basin (LIMB). Pressure transducers and ultrasound sensors located at different positions along the ice tank were used to monitor the wave propagation through the ice. Additionally, 3D motion of a few markers placed on the ice was tracked with an infrared camera system (Qualisys Motion Capture System). The progress of breaking was recorded with cameras placed above as well as sideways from the tank. The measurements consisted of two groups of tests, with a constant wave period in each group. The wave amplitude was increased stepwise, starting from a value too low to break the ice, until a major fragmentation of ice occurred. After each group of tests, the locations of cracks were determined and the floe-size distribution was estimated. The paper presents the data collected during the experiment, together with a short discussion of the observed breaking patterns and processes that created them.


Pulsed power technology has been used for the ablation tumor. Considerable research shows that a high-strength unipolar pulse electric field can induce irreversible electroporation (IRE) on the cell membrane, which can effectively kill cells. But some scholars and doctors have found that muscle contractions occur during treatment, which are associated with the delivery of electric pulses. Confirmed by further studies that bipolar pulses have been proven more advanced in the treatment of tumor because of the elimination of muscle contractions and the effect for ablating non-uniform tissue. So the bipolar pulse generator is needed for the research on the tumor ablation with bipolar pulses. In this paper, a new type of modular bipolar pulsed-power generator base on Marx generator with double power is proposed. The concept of this generator is charging two series of capacitors in parallel by two power sources respectively, and then connecting the capacitors in series through solid-state switches with different control strategy. Utilizing a number of fast solid-state switches, the capacitors can be connected in series with different polarities, so that a positive or negative polarity pulse will be delivered to the load. A laboratory prototype has been implemented in laboratory. The development of this pulse generator can provide the hardware foundation for the research on biological effect without muscle contraction when the tumors are applied with bipolar pulse electric field.


Component importance assessment is the important content of the power grid risk assessment and control, the existing methods cannot take the influence of weather condition and other uncertainties into account, meanwhile have problems such as single point of evaluation and low practicality. For this reason, a new assessment and ranking method for component importance is proposed. Firstly, incorporating the risk tracing model and three-state weather model, the method to quantize the contribution of each component to the system operation risk is studied under the framework of well-being risk analysis. On the basis of deriving allocation model of well-being risk index, emergency importance indicator(EII) and alert importance indicator(AII) are defined to indicate the importance of component from different aspects, respectively. Through the state enumeration method, typical expected contingencies sets are selected, and the operation risk of expected contingency are allocated to the individual component successively, then the assessment and ranking for component importance considering weather condition are completed. Case studies on RBTS and IEEE-RTS verify the scientificity and reliability of the proposed method.


The invention relates to a method for switching the network of a Java SIM card, an SIM card, a server and a system. An existing method of changing a mobile communication network is that the SIM card in a mobile phone must be changed, and comprises a plurality of complex procedures and steps, and a user generally needs to offer more time and energy. The method comprises the steps of receiving a network switching triggering instruction issued by a receiver, triggering an APPlet application and executing the network switching operation. According to the method for switching the network of the Java SIM card, the SIM card, the server and the system, the SIM card does not need to be changed when the communication network is changed, and smooth transition from the previous communication network to the new communication network can be realized for the user.


Recent expansion and sophistication of electric antenna applications in space missions increase the demand for better understanding of plasma and electromagnetic environment around the electric antenna and spacecraft. Because of strong plasma inhomogeneity emerging around the antenna and spacecraft, antenna behavior is difficult to resolve analytically and thus should be analyzed by means of some numerical approaches such as a plasma simulation. Actually, a practical merit of the plasma simulation has been demonstrated through its application to an analysis of antenna impedance in plasma [1]. Also, such a numerical approach has further advantages for an analysis of modern electric antennas equipped with distinctive devices: e.g., a photoelectron guard electrode, which greatly complicates the antenna-plasma interactions. In the present study, we apply the particle-in-cell simulations to the studies of the antenna and spacecraft environment. We particularly focus on electric properties of modern electric antennas used for static electric field measurements and plasma wave observations.


Numerical results are presented for the 2-dimensional turbulent transient heat transfer of the shell/tube heat exchanger with a step change of the inlet temperature in the primary side. Heat transfer boundary conditions outside the pipe are given partially by the convection heat transfer conditions and partially by insulated conditions. Calculation results were obtained by solving the unsteady two-dimensional elliptic forms for the Reynolds-averaged governing equations for the mass, momentum and energy. Finite-difference method was used to obtain discretization equations, and the SIMPLER solution algorithm was employed for the calculation procedure. Turbulent model used is the algebraic model proposed by Cebeci-Smith. Results presented include the time variant Nusselt number distribution, average temperature distribution and outlet temperatures for the various inlet temperatures and flow rates.


49 Conclusions: A link between DTI FA and mTBI history in the ILF and H may support the notion that mTBI has a role in impacting on inhibition networks. Future research would benefit from longitudinal analysis and inclusion of more subtle neuropsychological assessments. Use of DTI as a means of monitoring change in cumulative mTBI is supported. Objective: Obstructive Sleep Apnoea (OSA) is a common sleep disorder diagnosed in ≈28% of the population, with increasing risk in older adults and for males. OSA is characterized by repeated upper airway collapse, resulting in chronic, intermittent hypoxia and sleep fragmentation. Meta-analysis reveals that OSA causes cognitive difficulties in attention, memory and executive function (EF). Beebe and Gozal (2002) have proposed that sleep fragmentation and hy-poxia combine to lead to cognitive dysfunction. This study tested this hypothesis. Participants and Methods: Participants (N = 157) were recruited from the general public and from Sir Charles Gairdner Hospital, Perth. All participants underwent a full, diagnostic, polysomnography and completed cognitive assessment of attention, short-term & long-term memory and EF. One factor congeneric models were built to examine individual latent constructs of hypoxia, sleep fragmentation, executive function, attention, short term and long term memory. Finally a theoretically driven model was constructed to examine the relationships between hypoxia and sleep fragmentation, and cognitive function Results: Final model fit was good, X2(104) = 113.9, CFI = .84. After controlling for both IQ and daytime sleepiness, significant relationships were found between oxygen desaturation and sleep fragmentation to attention (p = .04, p = .02, respectively) and executive function (p = .05, p = .02 respectively). No significant predictors of memory function were found. Conclusions: These results confirm that more severe OSA is significantly associated with poorer attention and executive function. However , this paper provides only partial support for Beebe and Gozal's model. Whilst attention and executive deficits were related to fragmentation and hypoxia, LT and ST memory deficits were not. Memory dys-function in OSA may be a product of low mood and/or daytime sleepi-ness. Objective: White matter lesions (WMLs), asymptomatic lacunar in-farcts, brain microbleeds (BMBs) and enlarged perivascular spaces (EPVS) have been identified as silent lesions due to cerebral small vessel disease (cSVD). All these markers have been individually linked to cognitive functioning, but are also strongly correlated with each other. The combined effect of these markers on cognitive function has never been studied and would possibly provide more …


ABSTRACT A review of the theory of electromagnetic wave propagation along a system of horizontal wires in a layered medium is given. Numerical results for the propagation constants of a variety of specific structures are presented and examined as functions of wire and medium parameters. The full modal description of such structures is discussed, and its relation to excitation by specific sources is examined. Finally, a brief assessment of currently outstanding problems in this area is given.


We study compliance dynamics generated by a large set of behavioral rules describing social interaction in a population of agents facing an enforcement authority. When the authority adjusts the auditing probability every period, cycling in cheating-auditing occurs: Intensive monitoring induces compliance, but with high compliance there is incentive for lax monitoring; with less monitoring, compliance starts decreasing, and then there is an incentive to intensify monitoring. Thus, the real life phenomenon of compliance fluctuations is ex-plained by the nature of social interaction process rather than by exogenous parameter shifts. For the authority committed to a fixed auditing probability, we derive a sufficient condition for fines to be effective means of deterrence. Our analysis can be applied, among others, to crime, tax evasion, safety regulations, employment and environmental protection.


This aim of this research is to investigate whether or not applying the SQ5R technique improves the students' reading ability of the eighth grade students of SMP N 8 Malang. SQ5R is a reading technique which includes seven steps of activities: Survey, Question, Read, Recite, Record, React, and Review (Sangcharoon, 2010).

This research used a quantitative research, especially the experimental design. The researcher employed the quasi-experimental design since she gave the treatment to the selected group without any random pre-selection process. This study has two variables; they are independent and dependent variables. Independent variable is the implementation of SQ5R technique while dependent variable is the students' reading ability. The data of this research were analyzed using the independent T-test.

The result of T-test computation showed that the t-ratio was -5.03, with the level of significance of 0.50 and the degree of freedom of 62. The result of the data analysis showed that the value of SIG 2 tailed was .00 < 0.05; so, it is concluded that Ho (Null Hypothesis) was rejected. Therefore, the hypothesis stating that SQ5R technique improves the students' reading ability was accepted. It means that using SQ5R technique in teaching reading improves the students' reading ability of the 8th grade students at SMPN 8 Malang.


In thin photorefractive materials beam coupling can be observed in the Bragg, Raman-Nath and intermediate regimes, dependent on the geometrical properties of the incident optical beams [1]. By varying the grating spacing, achieved by changing the angular separation of the beams which create the grating, it is possible to move from Raman-Nath to Bragg regime. Application of simple Bragg [2,3] or Raman-Nath [4] models to a system in the intermediate regime could potentially lead to the derivation of incorrect coupling coefficients.


3D printing techniques allow for fabricating accurate structured and complex parts, designed via computer-aided design (CAD). In this research, we introduce extrusion 3D printing of optically transparent, high-water-content (96%) hydrogels toward fabrication of easy-to-make, cost-effective electromagnetic interference (EMI) shields. First, we designed polyacrylic acid soft hydrogels with different concentrations to achieve a 3D printable composition with desired rheological properties. Then, 4wt.% transparent hydrogel was printed into different structures on a cellulose acetate substrate. The 3D-printed (100% infill) hydrogels containing 96wt.% water demonstrated appreciable EMI shielding as high as 18.6 dB at a thickness of 1.6 mm. More importantly, it is shown that the 3D printing technique allows for macroscale patterning of the shields, providing more degrees of freedom in tuning the EMI shielding performance. Our achieved results validated that the 3D-printed transparent hydrogels attenuate EM waves noticeably, rendering them a superb candidate for high-performance optically transparent EMI shields.


-Climate change has become an increasingly severe issue due to frequent human activity. The global temperature is rising faster than ever, and it damages the ecosystem while increasing extreme events and threats to humans' daily lives. The need of alleviating climate change has become the top priority for many industries. This paper is aimed to study the role of the oil and gas industry in the energy transition process, since oil and gas industry, as one of the main producers of carbon dioxide, should take active action in achieving the goal of transferring 'oil and gas' to 'renewable energy' eventually to protect the environment. In this article, the author takes BP company as an example to have a deeper insight into oil and gas industry. The author analyzes the financial statement data by calculating different ratios to better understand BP's financial situation. Then principle component analysis (PCA) method is used to filter important figures by reducing 120 selected variables to 8 final principle components. This reduces the dimension of the original data and will help further data analysis. Besides, this article deeply analysis the necessity of Carbon Capture and storage technology (CCS), Direct Air Carbon Capture and Sequestration (DACCS) and the application of renewable diesel. The author believed that the application of these will be extremely useful during the energy transition.


Introduction: The excision is the treatment in case of Meckel's diverticulum symptomatics. The objective is to report our experience in the management by laparoscopy Material and Methods: Retrospective study over a period of 3 years rewiew the patients approached by laparoscopy. Results: 11 patients: 10 were bleeding gastrointestinal and the other was incidental. The mean age was 3.5 years, most frecuently in males. Of these cases, 5 had diverticulectomy the others six had resection and anastomosis. Ectopic gastric mucosa was present en 54.5%, don't showed ectopic mucosa in ileon or in the base of the diverticulum. The stay hospital average 8.8 days. Conclusions: Laparoscopy is safe and efficient for the diagnosis and definitive treatment of meckel's diverticulum for diverticulectomy or assisted resection and anastomosis Index word: Laparoscopy; Meckel's diverticulum.


Due to the development of aerospace technology in China, this paper proposes a method of characteristic line detection and matching to reconstruct the non-cooperative target. The geometric and algebraic constraints are given by its 2D images, and the linear equations about position and attitude of the aircraft relative to the non-cooperative target are deduced by n lines (n > 13). Then, by using the least-square method, the aircraft's motions are obtained. Lastly, the 3D target is reconstructed by utilizing aircraft's position and attitude. The extensive experiments over simulated images and parameters demonstrate the robustness, accuracy and effectiveness of the proposed method.


The Centers for Medicare &Medicaid Services (CMS) rulingon May 3 sets forth CMS policy concerning the requirements fordetermining payment for insertion of presbyopia-correcting IOLs following cataract surgery under thefollowing sections of the SocialSecurity Act (the Act):


U1B3.3 monoclonal antibody (mAb) was established by immunizing a rat with the tMK-2U lymphoma cell line, derived from athymic nude mice. U1B3.3 mAb recognizes some T cell populations, B cells and natural killer (NK) cells. U1B3.3+ T cells express CD3/T cell receptor (TCR) complex at a unique intensity: between that of TCR-intermediate cells (TCRint cells) and TCRbright cells. TCRint cells strongly express the interleukin-2 receptor β chain (IL-2Rβ), but almost all U1B3.3+ T cells express high or low levels of IL-2Rβ. When purified U1B3.3+ NK1.1-T cells were cultured with IL-2, approximately 14% of the cells acquired expression of NK1.1 molecules, which are expressed on NK cells and natural killer T (NKT) cells. Furthermore, U1B3.3+ NK1.1-T cells killed tumor cells after culture with IL-2. These results indicate that U1B3.3 mAb recognizes a precursor of NK1.1+ cytotoxic T cells generated by IL-2.


In this article the immunoferment analyses, results of mycotoxins infection in fruits which produced Aspergilluss species were shown. Facts testify that Afl atoxin contamination in studding samples has more concentration in food. Among studied fruits, the apples and grains were more dangerous. More than 55% fruits from diff erent Azerbaijan regions were infected with mycotoxins.


Amyand hernia is a rare presentation in inguinal hernias (less than 1% of cases with inguinal hernias) which is evidenced when in herniated masses the presence of inflamed appendix is ascertained or not. It was named after a French surgeon, Claudius Amyand (1660-1740), who performed the first successful appendectomy in 1735, where he found an acute appendicitis in a herniated mass. Most cases are diagnosed intraoperatively, as an accurate preoperative diagnosis rarely becomes evident.
Management is individual depending on the stage of inflammation of the appendix, the presence of abdominal sepsis and concomitant factors. The decision should be based on factors such as the patient's age, the size and anatomopathological shape of the appendix, and in the case of an inflamed appendix, standard appendectomy and retinal herniorrhage should be the gold standard of treatment.
Amyand hernia is usually misinterpreted as a common incarcerata hernia. Symptoms that mimic appendicitis may appear. Treatment consists of a combination of appendectomy and hernia repair. The inflammatory status of the appendix determines the type of hernia repair and the surgical technique. Occasional appendectomy in the case of a normal appendix is not recommended.
Amyand hernia is a rare type of inguinal hernia in which the appendix is located in the hernia sac. We present a case of a recurrent incarcerated Amyand's hernia with complicated appendicitis. The 78 old polymorbide patient with right-sided incarcerated recurrent hernia was emergently operated on and appendectomy and non-mesh hernioplasty performed, on the 3rd postoperative day for a heart attack he was placed cardio stimulator with uneventful outcome. Fifteen months follow up did not show complications or complaints.


The scars defining the Gebra valley reflects important instability processes, but the recent evolution of the valley is controlled by glaciomarine processes. The occurrence of instability processes through the valley points out the Gebra valley as a corridor for mass transport, or a debris-valley, from upslope to deep basin areas. The instability features are the dominant processes in the Gebra valley area which are characterized basically by the presence of scars, scarps, slides, turbidites, and mass-transport deposits.


[Objective] To retrospectively analyze the clinical findings, MRI features and surgery result of meniscal cysts in 11 cases. [Method] During the period between 1998 and 2006, 11 patients suffered from meniscal cysts were treated by arthroscopic surgery. Meniscal cyst were excised in all the cases. At the same time partial or total menisctomy was performed in 10 cases. The patients were assessed pre-and post-opratively by Lysholm score and Glasgow Assessment. [Result] Cysts and pain disappeared by arthroscopic surgery. Lysholm score showed a significance improvement from (74.2+11.6) pre-operation to (92.1+3.4) post-operation. According to Glasgow Assessment 10 patients (91%) of 11 patients were excellent in follow-up. [Conclusion] As the treatment of meniscal cyst arthroscopic surgery shows the advantages to maintain good function of knee and reduce the premature osteoarthritis occurrence.


The majority of Indonesian farmers are entirely dependent on the activities in the agricultural sector. However, the current agricultural system tends to works against farmers' welfare. This study aims to examine the role of local informal financial institutions in creating sustainable farmer welfare using a qualitative approach. The results of the study indicate that there is a dominant role of local informal financial institutions. This domination causes farmers to become helpless during harvest season, resulting in farmers' dependence on local informal financial institutions and their inability to enjoy sustainable welfare.


Objective
To evaluate the efficacy and safety of double dosage Tamsulosin in treating patients with type Ⅲ prostatitis.

Methods
According to the results of prostate secretion(EPS) examination and the national institute health-chronic prostatitis symptom index(NIH-CPSI) questionnaire, 120 patients with type Ⅲ prostatitis were recruited and randomly divided into single dosage group (n=60), treated with 0.2 mg Tamsulosin and placebo once daily for 12 weeks, and double dosage group(n=60), treated with 0.4mg Tamsulosin once daily for 12 weeks. Before treatment, the NIH-CPSI total scores in single and double dosage group were 26.91±4.08 and 27.31±4.98, respectively. The pain index in each group was 10.64±2.23 and 11.47±3.00, respectively. The voiding index was 6.52±2.24 and 6.41±2.97 respectively. In those groups, the quality of life index was 9.68±1.81 and 9.45±1.79, respectively. All those items didn't show significant difference among those groups (P>0.05). The patients were follow-up and evaluate by those items on weeks 12.

Results
Because of losing during follow-up, 4 patients were excluded from single dosage group. 2 patients were excluded from double dosage group. After treatment in single dosage group, the NIH-CPSI total scores were 12.11±3.60, pain index were 3.57±1.67, voiding index were 2.88±1.70, quality of life index were5.59±2.06.After treatment in double dosage group, the NIH-CPSI total scores were 9.90±4.15, pain index were 3.21±2.21, voiding index were 2.21±2.11, quality of life index were 4.50±1.97. After 12 weeks treatment, the NIH-CPSI total scores, pain index, voiding index, quality of life index in both two groups were improved(P 0.05).

Conclusions
Compared with single dosage Tamsulosin in the treatment of type Ⅲ prostatitis, double therapy had a better efficacy. Double dosage Tamsulosin therapy had an equal safety to the single dosage Tamsulosin.

Key words:
Type Ⅲ prostatitis; Tamsulosin; Double dosage


Temperate amphibians in colder regions are expected to store more energy prior to hibernation for successful overwintering and subsequent spring breeding. We tested this prediction on a capital breeding species — Rana chensinensis — using samples collected from 27 populations across 1200-km latitudinal (33.6–4.2°N) and 1768-m (112–1880 m) altitudinal gradient in northern China. Our data showed that frogs from colder regions (high latitude or altitude) had relatively heavier liver and fat bodies than those from warmer regions, but that the weight of carcasses tended to become smaller. The greater pre-hibernation energy reserves in colder regions could be an adaptive response to the longer and colder winter period, whereby meeting the energy demands for overwintering, and the subsequent energy requirements of reproduction in the spring.


The superfine calcium carbonate microspheres were prepared by emulsion liquid membrane method combining with precipitation method. The effects of different reaction parameters on the morphology of calcium carbonate microspheres were investigated. The obtained samples were characterized by X-ray Diffraction( XRD),field emission scanning electron microscope( FESEM), Fourier transform infrared spectroscopy( FTIR) and laser particle size instrument. The results indicate that calcium carbonate microspheres with the size of 5 μm were prepared when adding 4 mL Tween-80 and 0. 5 g PVP to the reaction system; The phases and the morphologies of calcium carbonate materials are closely related with the volume ratios of Tween-80 as well as mass radios of PVP.


Experimentation revealed that observation of smallangle double Bragg scattering rise is a satisfactory tool for the study of cold work in metals and for the study of recrystallization in face-centered cubic structures such as nickel. Observations conform to accepted ideas concerning the mosaic substructures of crystals. Since the diffuse scattering is calculated statistically, the method line metals. The method is thus ideally suited to the use of focusing small-angle scattering systems. (auth)


The current study aimed to examine the effects of personal growth (PG) on psychobiological responses at baseline and responsiveness to laboratory acute stress in students. Twenty-four healthy students were recruited as participants. Participants were screened from 203 candidates according to levels of PG using Ryff's scale and classified into high and low PG groups. During the laboratory session, 13 high and 11 low PG participants underwent the Trier Social Stress Test. Heart rate and high-frequency (HF) heart rate variability were monitored throughout the experiment. Salivary free-3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) and perceived stress were measured at baseline, immediately after tasks and after a recovery period. Baseline and recovery perceived stress (tense arousal) were significantly lower in the high PG group compared with the low PG group. Free-MHPG and HF component returned to baseline levels during recovery significantly more rapidly in the high PG group compared with the low PG group. There were no significant group differences in heart rate. The results showed that high PG students have lower noradrenaline and higher parasympathetic nervous system activity before and after acute stress. These findings suggest a protective psychobiological pathway linking PG with better psychosomatic health in students.


The approximately planar complex molecule, [Cu(C18H12N2O3)(C5H5N)], contains one L2− ligand (L2− is the dianion of 2-hydroxy-1-naphthaldehyde 2-hydroxybenzoylhydrazone), one Cu atom and one pyridine molecule. The Cu centre shows square-planar N2O2Cu coordination. The tridentate dianion has an intramolecular N⋯H—O hydrogen bond. Each pair of adjacent molecules is linked together by π–π stacking and Cu⋯N interactions, which lead to the existence of a dimer. Owing to C—H⋯O hydrogen bonds, these dimers are further assembled into a two-dimensional framework.


ABSTRACT We propose a universal robust likelihood that is able to accommodate correlated binary data without any information about the underlying joint distributions. This likelihood function is asymptotically valid for the regression parameter for any underlying correlation configurations, including varying under- or over-dispersion situations, which undermines one of the regularity conditions ensuring the validity of crucial large sample theories. This robust likelihood procedure can be easily implemented by using any statistical software that provides naïve and sandwich covariance matrices for regression parameter estimates. Simulations and real data analyses are used to demonstrate the efficacy of this parametric robust method.


The need for automated fact-checking is getting prominent with every passing day as the spread of misinformation is swelling over the ever-increasing stream of online content. We focus on fine-grained labelling of factual information in tweets to facilitate better fact-checking systems capable of providing improved justifications. In this paper, we present a token-level annotation of factual claims in tweets from Indian Twitter. To deal with the multilingual variety of the Indian diaspora, we deal with tweets in English, Bengali, Hindi, and their codemixed variants. To the best of our knowledge, this dataset is first of kind, both in terms of labelling scheme as well as data sources.


We describe octopamine responses of 3 large buccal neurons of Lymnaea and test the hypothesis that these are cAMP-dependent. The B1 neuron is excited by octopamine and the depolarisation is significantly enlarged (P < 0.05) by application of the blocker of cAMP breakdown, 3-isobutyl-l-methylxanthine (IBMX). The Bl neuron is also depolarised by forskolin, an activator of adenylyl cyclase. The B2 and B3 neurons are inhibited by octopamine, and the response is not affected by IBMX. Both cells are excited by forskolin. We conclude that the Bl neuron response to octopamine is likely to be mediated by cAMP, while the B2 and B3 responses are cAMP-independent.


Image representation is an important issue in computer graphics,computer vision,robotics,image processing and pattern recognition.In this paper,an improved binary image representation method using the NAM with triangles and rectangles(NAMTR),which is called the INAMTR representation method,is proposed.Also,a concrete algorithm of the INAMTR for binary images is presented and the storage structures,the total data amount,and the time and space complexities of the proposed algorithm are analyzed in detail.By taking some idiomatic standard images,such as ′Lena′,′Baboon′,and ′Peppers′,in the field of image processing as some typical test objects,and comparing the algorithm of the INAMTR with those of the classic linear quadtree(LQT) and the latest NAMTR,the theoretical and experimental results show that the former is obviously superior to the latters with respect to the numbers of subpatterns(nodes) and the data storage,and therefore it is a better method to represent binary images.


This paper describes an efficient method of segmenting cell nuclei from complex scenes based upon the use of adaptive region growing in conjuction with nucleus-specific filters. Results of segmenting potentially abnormal (cancer or neoplastic) cell nuclei in Papanicolaou smears from 0.8 square micrometers resolution images are also presented.


This study focuses on the question in how far dog
 owners are able to predict the behaviour of their dogs by the use of a questionnaire
 developed by SERPELL and HSU (2003) in comparison to a behavioural test that
 was developed for the German Australian Shepherd Club. 94 dogs of the breed
 Australian Shepherd were subjected to a specific behavioural test consisting
 of 23 test situations. The dog owners were rendered an owner-questionnaire
 with 101 questions to be answered before the start of the behavioural
 testing. Subsequent to the behavioural test series the answers of the dog
 owners were statistically processed and compared to the results of the
 behavioural test. The study offers via the C-BARQ-answers insights
 into how the breed of Australian Shepherd is subjectively evaluated by their
 owners. Additionally, the study provides objective information on which
 behaviours the Australian Shepherd breed typical shows in specific test
 situations. The comparison and statistical analysis between
 questionnaire-answers and behavioural test offers moreover details on the
 predictive power of the questionnaire. When comparing the owner replies in
 the questionnaire with the behavioural test, special focus was put on the
 behaviour categories "aggression", "excitability" and
 "fear and anxiety" as well as on 2 questions of the category
 "miscellaneous". The comparison between C-BARQ-questionnaire and
 behavioural test indicates a different reliability of the questionnaire in
 regard to the prediction of certain behaviours. Overall, for the behaviour
 categories "excitability" and "aggression" the owner
 answers via questionnaire are relatively reliable in comparison to the
 objective, verified behaviour the dogs showed in the behavioural test. In the
 category "excitability" 3 of 4 "pairings" showed a
 positive significant correlation between questionnaire and behavioural test.
 In the category "aggression" there was
 also a good matching. In this category 11 of 13
 "pairings" provided more frequently than simply by random chance
 correct answers. One "pairing" provided more frequently than simply
 by random chance false statements of owners, while another "pairing"
 revealed neither better nor worse answers than simply by random chance. By contrast, for the category "fear and
 anxiety" the C-BARQ proves not to be a suitable instrument to identify
 fearful dogs. The owner answers and results of the behavioral test showed for
 17 out of 18 "pairings" no significant matching; hence, the C-BARQ could by
 no means replace the behavioral test. In the category
 "miscellaneous" only 2 questions were analyzed and compared with
 the behavioral test. While the result to question 92
 ("playfulness") showed no valid predication, question 93
 ("liveliness") shows a positive significant relationship between
 owner-answers and the objective results of the behavioural test. As a result of the study it may be noted that the
 behavioral test is useful to test the behavior of dogs objective and
 comparable. The test was able to depict all behaviors important for the
 breeding capability – with the exception of the "overawing behavior". Moreover, the predictive power
 of owner questionnaires should always be seen with particular caution. They
 offer – at least in this study, for dogs of the breed Australian Shepherd –
 for certain behavior no reliable prediction. A possible explanation lies in
 the different education and skill level of the owner as well as in often
 prevalent emotional ties of owners to their dogs. Nevertheless,
 questionnaires have the advantage to ask for data that a behavioral test can
 not deliver - and are a great complement to the snapshot of behavioral tests.
 A combination of questionnaire and behavioral test could be seen as more
 reliable than referring to one method alone. Regarding the
 question of whether "factors" (in this case the concrete behavioral
 test situations) had influence on the behavior of dogs it can be noted that all
 dogs showed a behavior expected and adequate for a herding dog. None of the
 test dog showed in any test situation inappropriate behavior – indicating
 behavioral problems.


6 7 8 9 10 11 12 13 14 We demonstrate a scheme for volume holographic storage based on the features of shill selectivity of a speckle reference wave hologram. The proposed recording method allows more efficient use of the recording medium and increases the storage density in comparison with spherical or plane-wave reference beams. Experimental results of multiple hologram storage and replay in a photorefractive crystal of iron-doped lithium niobate are presented. The mechanism of lateral and longitudinal shift selectivity are described theoretically and shown to agree with experimental measurements. van


Lately, utility mining has grown as a developing area in Data Mining field. It remains computationally costly both as far as runtime and memory utilization. Data type, quality, and dimensionality of the dataset are some of the factors which aff ect the computational cost of utility mining. However, high dimensionality of the datasetcauses more difficulties in managing runtime and memory utilizationduring mining process as compared to the other two factors. A best possible solution could be the dimensionality reduction of the dataset in such a way that it should retain the significant information present in the dataset while discarding the noise.Hence it is a significant challengefor data mining researchers to design a more proficientmethod for extracting high utility itemsets. We develop a novel dimensionality reduction method in this paper by addressing the above issue for improving the efficiency of utility itemset miningwith restricted memory space and processing time.


The abstract highlights the close relationship between sentiment analysis and natural language processing (NLP), emphasizing their shared techniques and applications. Sentiment analysis, a subset of NLP, employs machine learning algorithms to automatically detect and categorize subjective information in text, focusing on determining the emotional tone or attitude conveyed. NLP, on the other hand, is concerned with enabling computers to comprehend, interpret, and generate human language, utilizing computational techniques to analyze and manipulate natural language data. The integration of sentiment analysis and NLP has resulted in the advancement of more advanced algorithms and techniques for the analysis and understanding of human language. For instance, sentiment analysis can be incorporated into an NLP pipeline to evaluate customer feedback datasets, allowing companies to monitor real-time brand reputation and customer satisfaction. Similarly, NLP techniques can enhance the precision of sentiment analysis by considering the context, syntax, and identification of named entities and other crucial features within the text. The combined capabilities of sentiment analysis and NLP find applications in various domains, including social media monitoring, customer service, market research, and healthcare. Researchers and practitioners are continuously refining algorithms and tools by leveraging the strengths of both fields, leading to the development of innovative approaches for the analysis and comprehension of human language. This, in turn, opens possibilities for novel applications in the future.


Objectives: To explore the dynamic changes, distributing pattern and significance of myocardial apoptosis in pressure overload induced left ventricular hypertrophy. Methods: A pressure overloading model was established by the constriction of abdominal aorta in SD rats . By their constricting or not, they were randomly divided into the operated and sham operated groups. The cardiac myocyte apoptosis index (CAI) was determined semiquantitatively by in situ TDT mediated dUTP nick end labeling (TUNEL). Results: ①Increasing significantly in 4 hours after the operation, CAI reached a plateau on the first day and maintained at high levels up to the 7th day, and decreased on the 14th day and more definite from the 21st day to the 100th day, which were all significantly higher than that in the sham operated groups (CAI is 0). ②Most apoptotic cardiac myocytes diffused across the cardiac sections but in the area of fibrous scar distributed in a manner of focus. The CAI in the area of interventricular septum and that of adjacent to endocardium were similar and both were higher than that in the adjacent area to the epicardium. ③The distributing ratio of myocardial apoptosis was decreased gradually in turns of the remnant myocytes (R) in the center of myocardial fibrous scars, and those of marginal(M), border(B), remote (Rm) to myocardial fibrous scars. Conclusions:①It was indicated that apoptosis of cardiac myocytes were involved in the early stage of left ventricular hypertrophy. Apoptosis of cardiac myocytes maybe act as an important role in the mechanism of the pressure overload induced left ventricular hypertrophy. ②Apoptotic cardiac myocytes were distributed with a widespread pattern and more densely covered in the area of interventricular septum and that of adjacent to endocardium.③The myocardial fibrous scar may be got worse because of the myocardial apoptosis of in or adjacent to it.


Little is known about the current state of freshwater biodiversity in Canada, one of the countries with the greatest amount of surface waters in the world. To address this knowledge gap, we compiled a list of all available assessments of conservation status for freshwater species (over 3,000 taxa) and further evaluated the overall status of six distinct taxonomic groups, focusing on organisms reliant on freshwaters [i.e., aquatic plants, invertebrates (with a focus on freshwater mussels), fishes, herpetofauna (reptiles and amphibians), birds, and mammals]. Overall, 11.7% of all freshwater species of plants and animals assessed were found to be 'at risk' (i.e., listed as 'Threatened', 'Endangered', or 'Extirpated') and 17.9% identified as 'Special Concern'. We found that 37.9% of species lacked sufficient data to enable their status to be assessed. Data gaps in Canada's assessment of its freshwater species were most prevalent in invertebrates (excluding freshwater mussels). Given the alarming state of freshwater biodiversity in Canada, we conclude by providing recommendations that focus on evaluating temporal trends and informing conservation actions.


Context. While the Solar System contains about 20 times more moons than planets, no moon has been confirmed around any of the thousands of extrasolar planets discovered so far. Considering the large computational load required for the statistical vetting of exomoon candidates in a star–planet–moon framework, tools for an uncomplicated identification of the most promising exomoon candidates could be beneficial to streamline follow-up studies.
Aims. Here we study three exomoon indicators that emerge if well-established planet-only models are fitted to a planet–moon transit light curve: transit timing variations (TTVs), transit duration variations (TDVs), and apparent planetary transit radius variations (TRVs). We re-evaluate under realistic conditions the previously proposed exomoon signatures in the TTV and TDV series.
Methods. We simulated light curves of a transiting exoplanet with a single moon, taking into account stellar limb darkening, orbital inclinations, planet–moon occultations, and noise from both stellar granulation and instrumental effects. These model light curves were then fitted with a planet-only transit model whilst pretending there were no moon, and we explored the resulting TTV, TDV, and TRV series for evidence of the moon.
Results. The previously described ellipse in the TTV-TDV diagram of an exoplanet with a moon emerges only for high-density moons. However, low-density moons distort the sinusoidal shapes of the TTV and the TDV series due to their photometric contribution to the combined planet–moon transit. Sufficiently large moons can nevertheless produce periodic apparent TRVs of their host planets that could be observable. We find that Kepler and PLATO have similar performances in detecting the exomoon-induced TRV effect around simulated bright (mV = 8) stars. Although these stars are rare in the Kepler sample, they will be abundant in the PLATO sample. Moreover, PLATO's higher cadence yields a stronger TTV signal. We detect substantial TRVs of the Saturn-sized planet Kepler-856 b although an exomoon could only ensure Hill stability in a very narrow orbital range.
Conclusions. The periodogram of the sequence of transit radius measurements can indicate the presence of a moon. The TTV and TDV series of exoplanets with moons could be more complex than previously assumed. We propose that TRVs could be a more promising means to identify exomoons in large exoplanet surveys.


This paper forms a bundling model between telecom platform and cable platform,and analyzes the cross penetration and reciprocal convergence in network industries based upon the Shanghai's "Convergence of Three Networks-Telecommunication network,Cable network and Internet".It can be concluded that the telecom platform bundled three businesses can effectively foreclose the market of cable platform which bundles two businesses by setting a lower price,and it could be a useful method to increase price levels and profits that compete by making product differences.The network platforms can benefit from economies of scope in bundled businesses,which acquires the convergence of business models of different networks.


Summary: The serum levels and side effects of, an acute oral loading dose‐schedule of carbamazepine (C) divitabs [CBZ controlled release (CR)] and phenytoin (PHT) were assessed in patients at risk of seizures. CBZ‐CR and PHT were administered to 42 adult patients (21 each) at a dosage of 20 mg/kg with a minimum and maximum dosage of 1,200 and 1,600 mg in patients weighing 80 kg, respectively. CBZ‐CR was given as single loading dose; PHT was split, with two thirds of the dose administered at 0 h and one third administered 2 h later. The 24‐and 36‐h doses were assessed according to the nystagmus status at 24 h. Mean CBZ serum levels (percentage of subjects with level >4 μg/ml shown in parentheses) were 0.0 (0%), 5.2 (62%), 6.7 (81%), 6.8 (95%), and 6.1 μg/ml(95%) at 0, 4, 8, 24, and 48 h after loading, respectively, and mean PHT levels (percentage of subjects with PHT level >10 μg/ml in parentheses) were 0.1 (0%), 13.2 (86%), 16.3 (loo%), 16.3 (l00%), and 15.4 pg/ml (82%). One subject in the CBZ group and 3 in the PHT group vomited. Clinical effects did not differ significantly between treatment groups and are reported. Acute doses of CBZ‐CR 20 mg/kg and PHT 20 mg/kg (two‐thirds at 0 h and one‐third at 2 h) provided therapeutic levels in most patients in G4 h and were well tolerated.


This paper concerns the characterization of various trunks of an OPGW based network. No strong fiber aging has been observed but combined OTDR and PMD measurements have pointed out strong cable clamping at suspension pylon. Large local losses have been measured at both 1.55 micrometers and 1.6 micrometers and stress induced birefringent behavior have been experienced. PMD temporal evolution has also been studied. A correlation between temperature variation and PMD evolution has been observed.


:Liu Zongyuan and Yuan Hongdao are representatives o n mountains-and-waters travel and their proses have the different style of lit erature. This thesis contrasts their different style from lyric way, technique o f writing and rhetoric, and probes into the mountains-and-waters travel's ten dency of development in China.


Most attention on possible catecholamine abnormalities in anorexia nervosa has focused on serotonergic systems. Clinical observations in patients with anorexia nervosa, including ascetic behaviors that extend well beyond self-denial of food, suggest altered hedonic mechanisms, possibly involving dopaminergic reward systems. Previous research in these patients has shown increased binding of dopamine D2/D3 …


Abstract Until recently, mosasaur remains from the Izumi Group (Upper Cretaceous) in southwest Japan comprised only scattered finds; now a richer material is available. From the upper Campanian Hiketa Formation in Kagawa Prefecture, Kourisodon sp. has just been recorded, on the basis of portions of skull and mandible which has small and laterally compressed teeth. A few teeth of the same or similar type have previously been described from the Maastrichtian Mutsuo Formation in Osaka Prefecture. A report of Mosasaurus sp. A, which resembles M. missouriensis and M. dekayi, is based on some cranial and mandible remains, inclusive of numerous teeth and a few well-preserved cervical and two incomplete dorsal vertebrae, from the Maastrichtian Mutsuo Formation in Osaka Prefecture. A slender tooth of Mosasaurus sp. from the Mutsuo Formation has since been reassigned to Platecarpus (Plioplatecarpinae); yet, this may indeed by a species of Mosasaurus, here listed as Mosasaurus sp. B. To date, smaller specimens of mosasaurids have been shown to be abundant in the Izumi Group, which suggests two possible explanations. Either most of these represent juveniles, or smaller-sized, Kourisodon-like animals flourished here. Finds of Kourisodon sp. from the upper Campanian Hiketa Formation and the Maastrichtian Mutsuo Formation suggests the second explanation is the more likely one.


This paper investigates the subjective assessment of QoE of web and video services over a mobile network. To achieve this, the authors used the network emulator (NetEm) traffic control functionality to simulate the dynamic behaviour of a mobile network. Experiments were conducted in a laboratory setting and test conditions were varied to ascertain the QoE, with a focus on QoE metrics such as delay and packet loss ratio. From the experiments conducted, it was observed that there was a negative correlation between delay and average mean opinion score (MOS), and between packet loss ratio and average MOS. The results obtained can be adopted by network operators to provide better services which would lead to improved subscriber base and profitability for the operators and better QoE for the end users.


The present paper focuses its analysis on the current state and the influencing factors of the labor relations standard of small-sized enterprises in China.Suggestions are proposed on the public policies and the enforcement of right preservation and harmonizing function of the Unions;on the perfection of the laborers' social welfare system and the mobile mechanism of their social security;and on the development of the social organization.