Swift J2218.4+1925, a hard X-ray source detected by Swift BAT, has been proposed as a candidate magnetic cataclysmic variable of the polar type from optical spectroscopy. Using XMM-Newton we perform detailed timing and spectral analysis with simultaneous X-ray ($0.3-10$ keV) and optical B band data. We complement the spectral study with archival hard X-ray (14-70 keV) spectra collected by Swift BAT as well as with optical, near and mid-infrared photometry from $SDSS$, $2MASS$ and $WISE$ archive, respectively. A strong periodic X-ray signal at 2.16 h, consistent with the recently determined spectroscopic orbital period, adds Swift J2218.4+1925 to the small group of hard X-ray polars and locates it at the low edge of the orbital period gap. The X-ray pulse profile shows the typical bright and faint phases seen in polars ($\sim 70%$ and $\sim 30%$ of the orbit, respectively). A pronounced dip centred on the bright phase is also detected. It is stronger at lower energies and is mainly produced by photoelectric absorption. A binary inclination $i \sim 40^o - 50^o$ and a magnetic colatitude $\beta \sim 55^o - 64^o$ are estimated. The source appears to accrete over a large area $\sim 24^o$ wide. A multi-temperature optically thin emission with complex absorption well describes the broad-band ($0.3-70$ keV) spectrum, with no signs of a soft X-ray blackbody component. The spectral shape varies with the source rotation reaching plasma temperatures up to 55 keV, hardening at the dip and being softer during the faint phase ($\sim7$ keV). We find the first indication of an absorption edge due to a warm absorber in a polar. Indication of overabundance of neon is found in the RGS spectra. The UV to mid-IR spectral energy distribution reveals an excess in the near and mid-IR, likely due to low cyclotron harmonics. We estimate a WD mass of 0.97 M$_{\odot}$ and a distance of 230-250 pc.


National Business Capital offers business funding, business financing and business capital loans to small, medium and large sized businesses nationwide.


Abstract : This article does research on the formulation of images and aberration characteristics associated with holographic lenses, and brings out the design principles, design programs, and actual examples for holographic head up display devices. Head up displays are one type of advanced observation and aiming instrument which is used in modern aircraft--in particular, in fighter planes. They are capable of supplying to flight personnel a wealth of flight information, and they have great significance for lightening the observation burden of flight personnel and raising the combat characteristics of the aircraft. As far as the important sections in the optical systems of head up displays are concerned, although they normally possess the strong points of familiarity of the industrial techniques in their manufacture, and their simplicity and ease of structural installation; however, due to such weak points as small field of vision and the contradiction between high transparency and high reflection, very great limitations have been placed on the exerting of the capabilities of head up displays devices. However, holographic lenses are still capable of very satisfactorily resolving these two problems. Because of this, one has seen the appearance of taking holographic lenses and replacing the holograph type optical systems of composite devices.


International expositions began to gain popularity in late 19th century, particularly in Europe, and in time came to influence both architecture and urban planning, affecting their historical development. Expositions serve as a means of displaying architecture, particularly since industrialization, and have an influence that can transform their surrounding metropolitan areas in different ways. These influenced areas extend way beyond their own scales, and even if they no longer exist today, and have the potential to transform the urban space in which they are located. This study analyses the case of the Great Exhibition of 1851, in London, United Kingdom, which can be considered as the world's first international event, and which played a significant role in the transformation of the Kensington site. Although the exhibition space itself was temporary, it transformed the Kensington site on which it was located at an urban scale.  Even though these structures are time-limited projects, they transform the urban space where they are located. Here, the relationship between the exposition and the urban is associated with the raindrop analogies. Each raindrop will create its own circle when it reaches to an accumulation of water. The nature of the circle can be changed based on the size of the raindrops and different factors; in the case of expositions, the construction of the structure starts the process as a raindrop and creates its first circle. This circular effect occurs the bigger circles and reaches further distance at an urban scale, so this analogy gives the urban form even if the exposition has gone. This analogy is also valid for the urban transformation of the Kensington Site. This part of the London has changed following the reorganization and redesign after the exhibition was over, and the exposition space has developed into an integrated part of the city by taking on a set of additional functions, with the additional influence also of such neighbouring institutions as museums and later exhibition spaces. The site of the exposition has become a symbolic landscape of London and particularly the South Kensington has served as a great model to represent how international expositions can have a great contribution to change, transform and redesign the urban with a specific meaning: Exhibition.


OBJECTIVE
Beta-blocking agents, particularly propranolol, are considered effective in the treatment of neuroleptic-induced akathisia, but considerable controversy exists about the involved receptor subtype(s). The authors conducted a randomized, controlled trial comparing the effects of propranolol and betaxolol to determine whether central beta 1-adrenoceptor blockade is sufficient to correct neuroleptic-induced akathisia.

METHOD
The subjects were 19 patients whose neuroleptic-induced akathisia responded to 20 mg/day of propranolol and subsequently reemerged during a placebo washout period. They were randomly assigned to propranolol (20 or 40 mg/day) or betaxolol (10 or 20 mg/day) and, after another placebo period, were switched to the second beta blocker.

RESULTS
There was no significant difference in the antiakathisia effects of propranolol and betaxolol.

CONCLUSIONS
The lack of difference between propranolol and betaxolol suggests that beta 1-adrenoceptor blockade is sufficient to improve neuroleptic-induced akathisia. The results of this explanatory study need therapeutic confirmation.


This thesis models rational criminals and regulators with flawed incentives. In it we develop a rational model of crime and regulation that we use to show the SEC's current incentive structure is ineffective at preventing fraud. Under our model, criminals balance the monetary rewards of larger frauds against an increased chance of being apprehended; and regulators design regulations to minimize either the damage caused by fraud or some other metric. We show that under this model, the SEC's focus on "stats" and "quick hits" leads to large frauds and a large social loss. We argue that regulators need to focus not just on successful prosecutions, but also on harm reduction and deterrence.


The reference design for the Canadian electrodynamically-levitated Maglev system makes use of a single-stator linear synchronous motor (LSM) and provides lateral stabilization by the use of figure-eight null flux loops. This paper presents an alternative approach using two independently-controlled linear synchronous motors with lateral stabilization provided by a simple null flux ladder. Some of the advantages of this approach are (1) a stiffer lateral stabilization is provided with much less material in the guidance loops, (2) active damping of roll and yaw moments can be provided by the dual LSM as well as the heave and surge damping which is available from a single LSM, and (3) the magnetic field in the passenger compartment is reduced.


Terms and conditions ... It is common in the socioeconomic planning sciences to seek to identify the conditions under which phenomena occur, not only as an interpretation or explanation of the social world, but also as a guide to planning. Indeed, many campaigns to change the social system seek to remove those conditions whose consequences are viewed as harmful and to supply those conditions whose outcomes are expected to be desirable. But central to both analysis and prescription is the old-fashioned distinction between necessary and sufficient conditions. A necessary condition is one which must be met before a phenomenon can occur, whereas a sufficient condition if present ensures that a phenomenon will occur. The distinction is difficult to apply in the socioeconomic planning disciplines for three reasons. First, in a large and complex system it is always possible that a supposedly necessary condition will prove, after all, to be dispensable. Second, in open systems it is difficult to be certain that all the conditions for sufficiency have been identified and explicitly stated. Third, if the causal systems in question are probabilistic (rather than deterministic) the arguments need to be handled with greater subtlety (Nowak, 1960). For these reasons the distinction between necessary and sufficient conditions is seldom made in social science texts [Blalock (1964) and Lipsey (1963) are important exceptions] and is often overlooked by social science researchers. This omission can lead to no less than twelve species of logical fallacy (table 1). The table introduces two new categories: conditions which are neither necessary nor sufficient, and conditions which are both necessary and sufficient. Some of the resulting fallacies (10, 11, and 12) are relatively benign—the failure to identify the importance of certain conditions for the existence of a phenomenon. Three (3, 6, and 9) are very blatant—the attribution of quite unjustified significance to unimportant conditions. The remaining six are more subtle and therefore more difficult to detect logically or empirically. To establish the logical possibility of a fallacy does not, of course, demonstrate that it occurs. But reading the three most recent issues of this journal which were at hand when this editorial was written revealed that all three issues carried apparent examples of these fallacies—apparent in that there may be evidence to support the assertions made, but that evidence was not presented. Even more dangerously, these fallacies lie at the heart of political debate: if the reduction of inflation to below x% is indeed a necessary condition for economic recovery, or even necessary


The occurrence and response of Na + -K + ATPase specific activity to environmental salinity changes were studied in gill extracts of all of the gills of the euryhaline crab Chasmagnathus granulata from Mar Chiquita coastal lagoon (Buenos Aires Province, Argentina) All of the gills exhibited a salinity depen dent Na + -K + ATPase activity, although the pattern of response to environmental salinity was different among gills As described in other euryhaline crabs highest Na + -K + ATPase specific activity was found in posterior gills (6 to 8), which, with exception of gill 6, increased upon acclimation to reduced salinity However, a high increase of activity also occurred in anterior gills (1 to 5) m diluted media Fur thermore, both short and long term differential changes of Na + -K + ATPase activity occurred among the gills after the transfer of crabs to reduced salinity The fact that variations of Na + -K + ATPase activity in the gills were concomitant with the transition from osmoconformity to lonoregulatio n suggests that this enzyme is a component of the branchial ionoregulatory mechanisms at the biochemical level in this crab


Summary form only given. 1,5-Diaminonaphthalene has been polymerized on platinum and glassy carbon electrodes - in acetonitrile solutions by potential cycling methods. The polymer films thus prepared have been characterized by electrochemical and in-situ spectroelectrochemical techniques. The polymer film grown on the platinum electrode in an aqueous solution had a conductivity of /spl tilde/ 1 x 10/sup -5/ S/cm . The number of electrons used for the polymerization reaction was found to be about 4 per mole of the monomer from coulometric experiments. The polymer structure, in which monomers are postulated to be linked with each other through 1- and 5-positions, was consistent with the infrared spectroscopic data of the polymer and coulometric data for the polymerization reaction. While the polymer shows major absorption peaks at 215 and 300 nm, it has a weak absorption at 525 nm in a 0.10 M HCL solution. When the polymer film is oxidized in 0.10 M HCI, the band at 350 nm undergoes a blue shift to about 290 nm with its absorption reduced and a new absorption band show up at 580 nm with its absorption extending to wavelengths longer than 800 nm. This behavior, which is typical for the system producing bipolarons upon electrochemical doping, is shown more clearly in the difference spectrum.


Part 1 The knowledge base for elementary physical education: how children grow the develop how exercise affects children how children develop movement skills how children learn motor skills psychosocial factors and children's movement. Part 2 The elementary physical education program: planning the curriculum organizing for teaching managing classes handicapped children. Part 3 Enhancing the program: using observation to improve instruction facilities and equipment evaluating children's physical education.


Metabolic dysfunctions continuously expose human erythrocytes to sugars present in plasma during their circulatory life span of 120 days. Hyperglycemia in diabetes mellitus causes glycation of proteins along with oxidative stress in erythrocytes. Moreover, acute systemic administration of D‐galactose was used to artificially induce blood senescence in human models as well to mimic galactosemia. The purpose of this study is to understand the effect of D‐glucose and D‐galactose in human erythrocytes and in particular on the function of Band 3 protein, which is an excellent tool for studying the oxidative events on the erythrocyte membrane. Human erythrocytes in vitro were exposed to increasing concentrations of D‐glucose (5‐15‐35 mM) for 3h or D‐galactose (0.1‐3‐5‐10 mM) for 1h. The rate constant for SO4= uptake, accounting for the efficiency of anion exchange through Band 3 protein along with levels of TBARS levels and membrane –SH groups have been measured. When erythrocytes were exposed to high D‐glucose (15–35 mM) for 3 h, TBARS levels and membrane –SH groups were unchanged while the rate constant for SO4= uptake was significantly accelerated with respect to control (5 mM). After exposure to high D‐galactose (5–10 mM) for 1 h, TBARS levels were higher and membrane –SH levels were lower than control, while the rate constant for SO4= uptake was significantly slower with respect to control (0.1 mM). The present findings show that the measurement of the rate constant for SO4= uptake is a suitable tool to monitor the effect of sugars on erythrocytes; hyperglycemia due to high glucose applied for 3 h affects anion exchange capability without producing lipid peroxidation and oxidative protein damage. High concentrations of D‐galactose (> 5 mM) decreased the rate constant for SO4= uptake, induced lipid peroxidation and reduced total sulfhydryl content. Based on this evidence, future studies will evaluate if the acceleration of Band 3 protein in presence of high D‐glucose depends on altered Bp3 conformation, affecting crosslink with Hb, or on altered glycosylation or phosphorylation signaling underlying Band 3 protein function. In addition, alterations of parameters of oxidative stress caused by D‐galactose on the erythrocytes membrane open the view to consider a potential therapeutic strategy ameliorating the damage caused by D‐galactose.


Risk stratification for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may help clinicians choose appropriate treatments and improve the quality of care.


For the purpose of reducing electricity cost and peak to average ratio (PAR), different electricity consumers have now an opportunity to schedule their electrical tasks. In this paper, we comparatively evaluated the performance of three meta-heuristic algorithms for our proposed Home Energy Management system (HEMS) i.e., Enhanced Differential Evolution (EDE), Harmony Search Algorithm (HSA), and Tabu Search (TS). The HEMS presented in this paper is based on Demand Side Management (DSM) and involvement of electricity consumers of a residential area domain to consider major factor of user satisfaction. In order to tackle the pricing for electricity bill calculation, a combined model of time of use (ToU) and critical peak pricing (CPP) is used. To deal with the scheduling of appliances a defined classification of appliances is taken from a part of literature. Simulation results verified that proposed techniques performed competently in achieving the above mentioned objectives.


Abstract This paper provides a new model to evaluate the yield stress of suspensions, slurries or pastes, based on the release of a finite volume of material onto a horizontal surface. Considering the height (h) and the radius (R) of the sample at the flow stoppage, two asymptotic regimes, where h > R or h < R, lead to different analytical models that allow the determination of yield stress. Experimental observations show typical sample shape at stoppage between slump (h > R) and spread (h < R). Based on these observations, we have developed a new analytical model to evaluate accurately the yield stress of materials in this intermediate regime. The validity of this model was evaluated from data obtained using various CarbopolR dispersions. The yield stress measured with the proposed model was compared with the yield stress evaluated from shear flow curves obtained with roughened plate/plate geometry fitted to the Herschel-Bulkley model. Results show the relevance of the proposed model which that can be applied in the range between models used for the two asymptotic regimes.


Abstract A revised framework is presented that quantifies observed changes in the climate of the contiguous United States through analysis of a revised version of the U.S. Climate Extremes Index (CEI). The CEI is based on a set of climate extremes indicators that measure the fraction of the area of the United States experiencing extremes in monthly mean surface temperature, daily precipitation, and drought (or moisture surplus). In the revised CEI, auxiliary station data, including recently digitized pre-1948 data, are incorporated to extend it further back in time and to improve spatial coverage. The revised CEI is updated for the period from 1910 to the present in near–real time and is calculated for eight separate seasons, or periods. Results for the annual revised CEI are similar to those from the original CEI. Observations over the past decade continue to support the finding that the area experiencing much above-normal maximum and minimum temperatures in recent years has been on the rise, with infreq...


Background. Our objective was to improve breastfeeding initiation rates at an urban medical center. Methods. A breastfeeding educational program for health care providers was developed and implemented in 1995. The outcome variable of interest was the change in breastfeeding initiation rate during 2 periods, 1993-1994 and 1996 to 1999, stratified by weight (>2,000, 1,500 to 2,000, and <1,500 g). Results. The breastfeeding initiation rate in 1996 to 1999 for all mothers of newborns admitted to the hospital was 47.1% (4,107/8,724), compared with the 1993-1994 rate of 18.9% (816/4,315). During the second period, the breastfeeding rate among mothers of infants <1,500 g was 60.8% (468/770), compared with 19.2% (56/293) during the earlier study period. Stratified by weight, the greatest improvement in rates of breastfeeding initiation and at discharge was seen with mothers of preterm infants. Conclusion. A breastfeeding educational program that interfaced with medical staff and mothers at an urban medical university was associated with increased rates of breastfeeding initiation. From the Division of Neonatology and the Division of Pediatric Epidemiology and Health Systems Research, Department of Pediatrics, Children's Hospital, Medical University of South Carolina, Charleston. Reprint requests to Carol L. Wagner, MD, Medical University of South Carolina, 165 Ashley Ave, PO Box 250917, Charleston, SC 29425. KEY POINTS • Breastfeeding rates in the Southeast remain significantly lower than those in other regions of the United States. • Educational programs that include mothers and health care providers are effective in improving rates of breastfeeding. • The acknowledgement of the importance of human milk for infant health and development during prenatal consultations appears to play a role in improving rates of breastfeeding ini-


OBJECTIVE
Infectious complications related to external ventricular shunt (ICREVS) are a main problem in neurocritical intensive care units (ICU). The aim of the review is to assess the incidence of ICREVS and to analyse factors involved.

METHODS
Retrospective analysis, adult polyvalent ICU in a third level reference hospital. Patients carrying external ventricular shunt (DVE) were included. Those patients with central nervous system infection diagnosed prior DVE placement were excluded.

RESULTS
87 patients were included with 106 DVE. Most common admittance diagnosis was subarachnoid haemorrhage (49.4%). 31 patients with 32 DVE developed an ICREVS. Infection rate is 19.5 per 1000 days of shunt for ICREVS and 14 per 1000 days for ventriculitis. 31.6% of the patients developed ICREVS and 25.3% ventriculitis. Patients who developed ICREVS presented higher shunt manipulations (2.0 ± 0.6 vs. 3.26 ± 1.02, p=0.02), shunt repositioning (0.1 ± 0.1 vs. 0.2 ± 0.1) and ICU and hospital stay (29.8 ± 4.9 vs 49.8 ± 5.2, p<0.01 y 67.4 ± 18.8 vs. 108.9 ± 30.2, p=0.02. Those DVE with ICREVS were placed for longer not only at infection diagnosis but also at removal (12.6 ± 2.1 vs. 18.3 ± 3.6 and 12.6 ± 2.1 vs. 30.4 ± 7.3 days, p<0.01). No difference in mortality was found.

CONCLUSIONS
One out of three patients with a DVE develops an infection. The risk factors are the number of manipulations, repositioning and the permanency days. Patients with ICREVS had a longer ICU and hospital average stay without an increase in mortality.


Abstract Background Psychological capital is closely related to primary school teachers' profession. It can not only promote the growth of teachers, but also directly affect the quality of school education and teaching and the growth of students. Therefore, it is particularly important to establish positive psychological capital in the pre service training stage of primary school teachers. The purpose of this study is to understand the current situation of the psychological capital level of primary school pre service teachers in China and the differences under the influence of different factors, so as to provide a basis for the relevant research on improving the psychological capital level of primary school pre service teachers. The corresponding training suggestions are put forward. Subjects and Methods This study selected 864 pre service teachers majoring in primary education from four normal universities and three comprehensive universities in China, conducted a survey through the Internet, and collected 831 valid questionnaires. According to the four dimensions of psychological capital, this study designed a questionnaire of psychological capital of pre service primary school teachers to investigate the level of psychological capital of pre service primary school teachers. Results The survey results showed that the psychological capital of pre service primary school teachers was generally at the upper middle level. There are significant differences in the overall level and dimension of pre service primary school teachers' psychological capital in terms of gender, origin and family economic status. Gender, family background and family economic status have a significant impact on the psychological capital level of pre service primary school teachers. Through the research, we found that citizens with higher levels of psychological capital have lower levels of anxiety and depression. Therefore, we can think that citizens with high internal psychological capital can alleviate the psychological pressure, anxiety and depression brought by psychological capital to a great extent through their own psychological quality. We also found that relatively speaking, citizens with high individual psychological capital are less affected by family factors, work and life, traffic safety, their own health and future fear. Teachers with high level of psychological capital will deal with the influence of family factors well. They are full of hope for the future and optimistic about life, and will not worry too much about the impact of life. From the questionnaire survey results, the internal consistency: odd and even split half reliability coefficient is 0.86 (Spearman Brown correlation coefficient is 0.93). Retest consistency: the stability coefficient of the scale retested within a few weeks is usually 0.70-0.80. It shows that the influence of students' Psychological Capital on anxiety is very key. If the patient is asked to answer according to the situation of the day, BDI evaluates state anxiety. If the patient is asked to answer according to the situation of the past week, the stability is much better. From the aggregation validity: BDI was significantly correlated with the evaluation of clinical depression, and the correlation coefficient was 0.60-0.90, which varied with the sample size. BDI score is also related to other clinical indicators, such as biological examination, electrophysiological examination, psychosocial test and the degree of sleep disorder. Therefore, its correlation with other scales must be good (r value range is 0.50-0.80). Factor analysis of BDI often leads to three interrelated factors: negative attitude or suicide, physical symptoms and operational difficulties. When the three factors are further (secondary) extracted, a "overall depression" factor can be obtained. The correlation of three skew factors and the generation of a single quadratic factor show that the internal consistency of the scale is good. Discriminant validity: the correlation between BDI and clinical depression (0.59) was greater than that with anxiety (0.14). Some authors doubt the discriminant validity of BDI, especially for anxiety and depression, but it can be used to distinguish different types of depression and different diagnoses. In addition, the answer to BDI items may be affected by social expectations, that is, to answer according to expectation tendency. The correlation between BDI and Edwards social expectation scale is about 0.80, because the latter partially shows people's self-esteem. Conclusion The survey found that although the psychological capital of pre service primary school teachers is generally at the upper middle level, there is still much room for improvement. In order to enable pre service primary school teachers to better engage in the profession of primary school teachers, the improvement and training of psychological capital should be incorporated into the mental health education system of pre service primary school teachers, and pre service primary school teachers should be trained in optimism, hope, health and health, self-efficacy and resilience, so as to develop their own psychological potential and improve their competitive advantage.


We present an analysis of ground‐based optical photometry and spectroscopy and Rossi X‐Ray Timing Explorer X‐ray observations of the old novae DI Lacertae and V841 Ophiuchi. Our optical photometry data (obtained with the automated photometry telescope RoboScope) comprise an almost decade‐long light curve for each star, while the contemporaneous spectroscopy and X‐ray observations repeatedly sampled each nova during separate intervals of ≈45–55 days in length. The long‐term optical light curves of both novae reveal quasi‐periodic variability on typical timescales of ∼30–50 days with amplitudes of ΔV∼0.4–0.8 mag. V841 Oph also displays a long‐term, sinusoidal modulation of its optical light on a timescale of 3.5–5 yr. The optical spectra of these novae display quite different characteristics from each other, with DI Lac showing narrow Balmer emission cores situated in broad absorption troughs while V841 Oph exhibits strong single‐peaked Balmer, He i, and He ii emission lines. We find little change between spectra obtained during different optical brightness states. The X‐ray count rates for both novae were very low (≲1.5 counts s−1), and there was no reliable correlation between X‐ray and optical brightness. The combined X‐ray spectrum of DI Lac is best fit by a bremsstrahlung emission model (with kT∼4 keV and NH<1.8 × 1022 cm−3); the X‐ray spectrum of V841 Oph is too weak to allow model fitting. We discuss the possible origin of variability in these old novae in terms of magnetic activity on the secondary star, dwarf nova type disk instabilities, and the "hibernation" scenario for cataclysmic variable stars.


Abstract In this article, it is argued that new football supporters tend to aspire downwards in their attempts to be accepted as authentic supporters. By this, it is meant that the historical traditions of football as a working class sport lead to the assumption (often mistakenly) that current fan cultures in football somehow constitute an authentic expression of traditional working class culture. Football supporters stress the importance of loyalty and passion, and of being critical towards the increasing commercialization of the game. Football authorities have in many ways succeeded in developing football into an important part of the culture industry since the 1980s. The middle classes are attracA'ted to the game by increased merchandising and improved facilities at more modern football arenas. Modern top football has become an important part of public life. From this fact, it is reasonable to assume that the alleged working class culture is marginalized. However, the new middle classes do not seem to have established any cultural hegemony in football culture. Rather, they are trying to internalize the traditions of the core groups of supporters. It is concluded that knowA'ledge of the A¢â'¬A"working classA¢â'¬Â traditions of football serves as football-cultural capital. Some examples are considered, including the work of Nick Hornby on football. Keywords: Football, class identity, commercialization of football


The recognition of Intellectual Capital as a source of competitive advantage and differentiation element for organizations requires an application of new management strategies that include this feature. Considering the importance of the Accounting Information System (AIS) in organizations, the research has the main objective to investigate the contributions of accounting as Management Information System in management of Intellectual Capital in an organization. Therefore, it was adopted a single case study as research strategy, applied in a Brazilian industry of consumption goods, on the market for over 85 years. The results obtained in the documentary analysis, questionnaires, interviews and literature show that the Accounting Management Information System (AMIS) contributes to the management of Intellectual Capital. In the investigated organization, AMIS is widely used and shows similarities with the specifications found in the literature, possessing the ability of adaptation to receive indicators or variables that enable the management of Intellectual Capital. It was found that the incorporation of the variables of Intellectual Capital in AMIS could be accomplished by adopting the method proposed by López-Ruiz and Nevado-Pena, that uses both traditional financial indicators and indicators of Intellectual Capital, not conflicting with the traditional AMIS, but complementing it. Inserting variables of Intellectual Capital in AMIS also allows uniformity of understanding on the subject by all company managers.


population growth, housing is a more critical issue for the nation's 38.8 million Hispanics** than ever before. Housing is the largest expense of the typical American household, and housing conditions are often reflective of other financial and educational opportunities. While there were some improvements during the 1990s, Hispanic families face serious affordability issues and are more likely than other Americans to reside in NCLR NATIONAL COUNCIL OF LA RAZA


In this study I have compared classic and fuzzy logic and their usefulness in clinical diagnosis. The theory of probability is often considered a device to protect the classical two-valued logic from the evidence of its inadequacy to understand and show the complexity of world [1]. This can be true, but it is not possible to discard the theory of probability. I will argue that the problems and the application fields of the theory of probability are very different from those of fuzzy logic. After the introduction on the theoretical bases of fuzzy approach to logic, I have reported some diagnostic argumentations employing fuzzy logic. The state of normality and the state of disease often fight their battle on scalar quantities of biological values and it is not hard to establish a correspondence between the biological values and the percent values of fuzzy logic. Accordingly, I have suggested some applications of fuzzy logic in clinical diagnosis and in particular I have utilised a fuzzy curve to recognise subjects with diabetes mellitus, renal failure and liver disease. The comparison between classic and fuzzy logic findings seems to indicate that fuzzy logic is more adequate to study the development of biological events. In fact, fuzzy logic is useful when we have a lot of pieces of information and when we dispose to scalar quantities. In conclusion, increasingly the development of technology offers new instruments to measure pathological G. Licata Department of Clinical Neurosciences University of Palermo, Palermo, Italy G. Licata ( ) Via Catania 166 I-90141 Palermo, Italy e-mail: email@example.com G. Licata: Probabilistic and fuzzy in clinical diagnosis 101 I M cians inexperienced in scientific logic, A, B and C may appear very similar too, but if taken as such their seeming analogy could originate fatal errors. In this study I will try to show the better adequacy in the field of clinical diagnosis of probabilistic logic and of fuzzy logic in comparison to classical logic, namely the increased adequacy of conclusions like B and C than conclusions like A. I will use clinical diagnosis as a paradigm to be discussed for its particular adequacy, in our culture's frame, to show the difference between the three logical paradigms previously indicated. In conclusion I will suggest a more precise distinction between the fields and the usefulness of the theory of probability and those of fuzzy logic. Comparison between classical logic and probabilistic logic in clinical diagnosis I will propose a comparison between some argumentations of classical logic and the analogous ones suggested in probabilistic logic. The usual argumentations employed by doctors to obtain a nosographic diagnosis follow the classical rules of inference: modus ponens, modus tollens, hypothetical syllogism, disjunctive syllogism. 1. The argumentations following the modus ponens are those which show this form: If P shows the symptoms S1, S2, S3 then P is affected by D1 P shows the symptoms S1, S2, S3


A nonlinear method has been developed to estimate climate feedbacks based on the Neural Network (NN) taking advantage of its self‐learning skills. The NN model developed here is trained using a reanalysis data set and predicts radiation flux globally from atmospheric and surface variables. The radiative feedbacks of temperature, water vapor, surface albedo, and cloud in the interannual climate variations estimated from the NN method are in agreement with those from a broadly used kernel method. However, the NN method demonstrates significant advantages: (1) it withdraws the linearity assumption of the kernel method and accounts for the nonlinear effects of the feedbacks. In the case of large climate perturbations, such as that in the Arctic caused by sea ice melt, the NN method achieves better radiation closure. (2) The method can directly calculate the radiative feedback of cloud and its components. We find that the high, middle, and low cloud feedback components analyzed from the NN method are linearly additive in the interannual climate variations, although there is a considerable nonlinear effect arising from the interactions between cloud and noncloud variables.


An open rectangular cavity has served as a generic geometry in shock tunnel experiments with laminar flow being two‐dimensional upstream of the cavity. A high order central difference scheme with flux‐corrected transport has been employed to simulate the flow under the assumption that the inflow profile upstream of the cavity is laminar. The high order in space enables to reproduce well vortical structures and possible transition to turbulent flow.


The article explores the state of the air basin of the Chelyabinsk agglomeration and gives the examples of solutions for the pollution problems from the point of view of city planning. The main features and structure of the modern urban agglomerations are considered, the methods for determining their boundaries are studied and the main problems are identified. The study of the boundaries and territorial structure of the Chelyabinsk urban agglomeration is conducted, and a general description of the territory is given. The data on the change in the volume of pollutant emissions into the atmosphere and the index of atmospheric pollution for the period 2003-2015 are given basing on the annual comprehensive reports regarding the state of the environment. The review of the world experience of city-planning actions on the decision of ecological problems is carried out. The most suitable ways for the ecological problems solving in the Chelyabinsk agglomeration are considered. The authors give recommendations for the ecological situation improving in the territory of the Chelyabinsk agglomeration.


Under the electric power market environment, the hydroelectric power plant should synthesize the economy and the technical characteristic of hydroelectric power, consider each kind of uncertainty factor in the bidding process, carry on the decomposition and the assignment in many time intervals and in many markets to reduce the overall risk, and enable the electricity generation side to achieve the high income low risk electricity generation goal. In view of the single time interval risk measure's insufficiency, this paper proposes one new kind of multi-time interval water electricity system optimization scheduling model. This model takes the total risk of multi-time to be low as a goal under the electric power market condition, simultaneously considers the overall price fluctuation and the uncertainties of water to generation side economic efficiency influence, and takes into account the storage capacity of hydropower stations, discharge, the unit output and other constraints, in order to follow the optimal scheduling scheme. Simulation results show that the model can reflect the essential characteristics of market risk under the spatial and temporal distribution of water electricity, and ensure the system safe and reliable and the smallest risk, so as to provide a new way of thinking of optimizing the operation decision-making and risk assessment of hydropower generation company.


Apparatus for precisely locating a point light source and identify one direction using at least three sources. It comprises two cylindrical diopters 2, 3 focus a linear array of photosensitive elements 1, and associated with one of the diopters, a prism assembly 4, 5 performing an image rotator 90 degrees, the set for determining by calculation from the detected signals the direction of the source location. With a triangle of three sources arranged on a movable annex structure without physical contact with the device, the directional locator is obtained an axis related to the structure. The invention applies in particular in helmet sight systems.


Most existing activity-based travel demand models are typically implemented on a tour-based microsimulation framework. Two approaches are available to describe people's daily decision-making processes on activity and travel in the activity-based model framework: rubber banding and growing scheduling. The growing-scheduling approach requires a series of linked dynamic discrete choices of activity episodes, locations, and travel modes to build incrementally an entire day's activity-travel patterns for individuals in households. To incorporate explicitly time dependencies into activity episode choice and duration, a hazard-based duration model in a discrete-time framework is introduced; this framework is essentially the same as a discrete choice model with temporal dummies as the simplest form of dynamic discrete choice models. In the application of the discrete–time duration model to activity duration analysis, complex situations of activity-travel data are considered; these include multiple states of origin activity, competing risks of destination activity, and a multilevel structure for recurrent activity episodes within individuals. In addition, a circular, or periodic, variable is introduced as a combination of sine and cosine to model time-of-day effects.


This paper describes the application of a set of advanced composite curves to evaluate the potential to release usable excess heat (hereafter referred to as Qxs) from an existing process industry. Throughout this paper Qxs is defined as heat at enough high temperature to be interesting for use e.g. for district heating. Studies using the advanced
curves reveal information about the existing HEN that traditional graphical methods are not able of, and that for almost the same collected information from the process. This allows for estimations on the heat recovery potential and existing pinch violations before detailed calculations.
These curves have earlier been presented in connection with integration of CHP, HP and retrofitting HEN's. The curves have also been used to evaluate the Qxs potential in one doctoral thesis, but the methodology was not explained in detail, but rather used as a tool among many. In this paper we broaden the discussion on how to use the curves, which
traps there might be and how to interpret and use the results. Important questions that are answered are for example:
• How does the Qxs potential change when the pinch temperature changes?
• At which temperature is it possible to release Qxs?
• How could the Qxs be made available?
• How can the Qxs potential be revealed?


The problem of political stability in the transitional period of China is a topic of great concern for Chinese and for- scholars, many of whom have analyzed this topic with different theories and methods. In this paper, institutional theories are empployed in investigate the influences of the institutional balance of the Chinese government on the interests of different subjects and possible changes in the political environment. It is believed that the Chinese government plays a dominant role in the process of market development in connection with the economy. The provision of institutions by the government the Chinese government of maintaining the balance of interests throughout society by means of institutional balance is the of political stability in China.


We report a case of a successful mobilization and harvest of the peripheral blood stem cells (PBSCs) in imatinib-pretreated and nilotinib treated 52-year-old woman diagnosed with Philadelphia chromosome-positive and BCR-ABL (b2a2) positive chronic phase CML in 2/2002. She failed interferon-alfa and imatinib treatment. She achieved her first complete molecular remission after 16 months of nilotinib treatment and later on was mobilized with filgrastim at a dose of 10 ug/kg/day applied subcutaneously once daily. The total number of 2.98 × 106 CD34+ cells/kg was harvested on the fourth day of the mobilization. The autologous graft of the stem cells was cryopreserved and tested for the residual disease: the FISH revealed negative results and the RT-PCR was positive (BCR-ABL/ABL ratio 0,0017 in RQ-PCR). To our knowledge, this is the first report of successful PBSC harvest in a patient significantly pretreated with imatinib and nilotinib.


Different combinations of fly ash and chemical admixtures can drastically affect the hydration behavior of Portland cement. In addition, other variables such as aggregate source, mixture proportions, environmental conditions, placement techniques and curing conditions can further complicate concrete field performance predictions. Tests were performed to illustrate the effects of fly ash and the effects of combined fly ash and chemical admixtures on cement hydration. Suggested guidelines to avoid abnormal setting behavior of concrete mixtures include: performing trial batches for all particular mixtures, monitoring the admixture dosage rates in the field, and avoid substituting a different class of fly ash without evaluating the concrete mixture.


With the development of the vehicle industry, intelligent vehicle become the trend of the times. Motor driver modules are the important components of the smart car. Based on the purpose of exploring different frequency PWM control motor output, the use of simulation software to Multisim12 b RC for the study, work profile to the circuit simulation experimental test was conducted. Given simulation programme, analysis of circuit waveforms with PWM at different frequencies. Through practical testing, the motor drive module can be used very well in the smart car motor.


Along with the development of GPS technology, the appearance of RTK, and the rapid development of computer technology, plane position technology realizes high precision, automatization, digitisation, and real time. And along with the digitization and automatization of measure depth technology, they provide the basis of digitization and automatization for underwater topometry, provide the advanced measure for hydrographic survey. This paper introduces the makeup, working theory, job method of the full self-motion digital underwater topometry system, and according to the engineering practicality, analyses the survey precision and the error source.


Polycystic Ovary Syndrome (PCOS) is defined as polycystic ovary syndrome is a hormonal disorder that occurs in women of reproductive age. There are 4 possible phenotypes for a patient with PCOS. These phenotypes are ruled out based on 3 criteria. They are hyperandrogenism, anovulation and polycystic ovarian morphology. The key goal of the therapy in PCOS is the management of symptoms. Treatment options should be based on the patient's choice for contraception and pregnancy. Treatment focuses primarily on the treatment of infertility, regulating menstrual irregularities, reducing the symptoms of hyperandrogenism or treatment of obesity. Treatment primarily includes oral contraceptives, clomiphene citrate, cyproterone acetate, metformin, Flutamide, spironolactone, Finasteride, ketoconazole, steroids. Oral contraceptives are considered the first line of therapy in the treatment of PCOS. Risks include venous thromboembolism. Commonly preferred oral contraceptives include Clomiphene citrate, Cyproterone acetate, Drospirenone, Ethinylestradiol, norethindrone. Metformin has insulin-lowering effects by improving insulin sensitivity and, in turn, can decrease circulating androgen levels. it may also help reduce hirsutism although this may take several months and Metformin may not be as effective as other treatments for hirsutism. As the diagnosis and treatment are still unclear, every day newer therapeutic options have to be explored. Long term use of OCP should be monitored and follow up should be done. The patient should be counselled regarding PCOS and its complication which might occur in future. Early intervention can minimize complications and the patient can achieve a healthy lifestyle.


Background: the International Association for the Study of Pain (IASP) publishes since 1986 a relatively frequently updated list of pain terms with corresponding definitions and clarificatory notes currently known as the 'IASP  Taxonomy'.  The   last  update,   i.e.   the  May  2012  version of this taxonomy, was subjected to an analysis with the goal to assess whether the definitions of the IASP terms that are used to describe findings of somatosensory testing and pain assessment satisfy the conditions for these terms to become part of a realism-based ontology. Results: the taxonomy was found to be built on definitions that are not in every case based on necessary and sufficient conditions, nor satisfy the single inheritance principle for realism-based ontologies. Furthermore, although the documentation about introduced changes provided by the IASP makes it clear that the terminology authors tried to solve ambiguities and unclarities present in previous versions, they did not succeed completely and introduced even some inconsistencies. The analysis demonstrates that the main cause for this is not the choice of differentiating characteristics, but rather insufficient attention to the wide variability in stimulus/response combinations that these characteristics reveal. Conclusions: the IASP taxonomy is not fit to form the basis for a realism-based ontology. A new representation framework for describing pain assessment findings more accurately using the same set of differentiae is proposed and its correspondence with the traditional terminology explained. Keywords—pain terminology, ontological realism


It is provided an improved process for preparing peptide epoxy ketones, including novel compounds that can be used as intermediates in the process for preparing Carfilzomib and other peptide epoxy ketones.


Certain optional phonological processes may apply to any number of the potential targets in a form, yielding outputs in which the process applies to a proper subset of the available loci. Such patterns are incompatible with OT-based frameworks that produce variation by providing multiple constraint rankings. While one ranking may favour exhaustive application and another no application, no ranking favours application at just some loci. The framework presented here, Markedness Suppression, solves this problem: eval may ignore any violation mark assigned by designated markedness constraints, creating variation by manipulating candidates' violation profiles. By ignoring different violation marks on different evaluations, the full range of attested forms is produced, including ones with intermediate levels of process application. Markedness Suppression achieves better empirical coverage than competing frameworks, in terms of both producing the correct range of variants and modelling their output frequencies.


Note Eighty-three Holstein-Friesian virgin heifers were randomly divided into four groups and superovulated with one of the four FSH regimens as follows : Group I) twice daily injections of a constant dose of 5 mg of FSH for a period of 4 days, giving a total dose of 40 mg in 8 fractions ; Group II) as in Group I with additional 5 mg of FSH on the 5th day, giving a total dose of 45 mg ; Group III) twice daily injections on a decreasing dose regimen of 5,4,3 and 2 mg successively for 4 days with the addition of 2 mg of FSH once on the 5th day, giving a total dose of 30 mg; Group IV) similar to Group III, but a mixture of FSH and LH in the ratio of 5 : 1 was used, giving a total dose of 30 mg of FSH and 6 mg of LH in 9 fractions. Nonsurgical embryo recovery was performed 7 or 8 days after estrus. Percentage of good embryos in Group II was significantly greater than that in Group I (P<0.05). There was no significant difference between Groups II and III in any of the criteria analyzed. Group IV was superior to the other groups in superovulation rate and embryo yielding. Significantly greater numbers of total eggs and good embryos were observed in Group IV compared to those in Groups I and II (P<0.05). Percentage of the heifers with more than 3 good embryos in Group IV was significantly higher than that in Groups I , II and III (P<0.05).


In this paper we address the optimization problem of multilevel logical functions using algorithms based on natural process. We show the results found by applying the simulated annealing algorithm and a genetic algorithm to area optimization of multilevel logical networks using the IWLS'93 benchmarks.


The results of this study, based on major and trace element compositions of 25 moldavites from the Bohemian, Radomilice, Moravian and Lusatian strewn fields and Nd-Sm isotope ratios of three moldavite samples, corroborate the conclusion established in earlier publications (Luft, 1982; Engelhardt et al., 1987) that Middle Miocene sediments are the most probable source materials of moldavites. These unconsolidated sediments, belonging to the Obere Silowasser-Molasse Formation (OSM), covered the area of the Ries crater at the time of the impact and are still preserved south of the structure (Engelhardt et al., Fig. 5). The lithology of this fluviatile formation is very well known from a systematic sedimentological investigation of a great number of OSM samples from surficial out-crops and many bore holes in the area south of the Danube (Lemcke et al., 1953) and from the samples collected in the Ries area by Luft (1982). These observations show that the OSM formation consists of an irregular sequence of lenses of limited lateral extension, com-posed of more or less clay bearing sands, mark (dolomitic) and clays. The proportions of the main components of sand, carbonate and clay in locally deposited OSM sediments are, therefore, variable, even over short distances. The compositional differences between moldavites


Yang Shuda's Glimpse into The History of the Han-Dynasty(汉书窥管)is of textual research. It aims at a correct interpretation of The History of the Han-Dynasty(汉书)from acceptation and grammar analysis. The method employed in it is that of sentence pattern analogy for analyzing the order of words and clauses, acceptations, function words syntax structures and so on. The method of sentence pattern analogy is handed down by ancient scholars, and it is one of the traditional methods in ancient Chinese grammar studies.


Splenic artery aneurysms (SAA) are the common of the visceral artery aneurysms. They represent the third most common intra-abdominal aneurysms after aortic and iliac aneurysms. The reported incidence of splenic artery aneurysms at autopsy varies, rising from 0.01% to 0, 2% in all age groups to 10,4% in the geriatric population. More than 80% are located in the mid or distal splenic artery (1). SAAs are rarely over 3 cm in diameter. There have been few cases of giant SAAs reported in the literature (2,3). Ultrasonography (US), Doppler US, Computed tomography (CT), Magnetic resonance imaging (MRI) is radiological modalities that used for diagnosis (4). We present computed tomography findings of giant SAA that is 8x10 cm in diameter in 60-yearold female.


Thin-film transistors (TFTs) that use an organic semiconductor as the active component have received considerable interest as promising candidates in switching devices for active-matrix flat-panel displays, organic sensors, and organic smart cards. [1–3] Among the many conjugated molecules thought to possess a sufficiently high charge mobility, the pentacene molecule has been considered as the most highly promising material for use in organic thin-film transistors (OTFTs) because of its reasonably high field-effect mobility and good semiconducting properties. [4–5] A large number of studies have focused on improving the performance of pentacene-based TFTs by optimizing the deposition conditions, such as the deposition rate, [6] substrate temperature, [7] roughness, [8] and surface treatment. [9] In addition to the growth conditions, the carrier mobility in OTFTs depends strongly on the degree of p -orbital overlap between adjacent molecules. [10] Moreover, the charge transport in pentacene has a two-dimensional character and occurs within the layers mainly in directions that are nearly perpendicular to the long molecular axes. [11] Thus, the best way to increase the carrier mobility is to grow organic molecules with an appropriately preferred orientation relative to the source/drain electrodes. This means that the optimal p -orbital overlap direction should be aligned parallel to the charge transport direction. However, thin-film growth techniques in organic electronics lack control of the in-plane orientation of molecules. It is therefore of prime interest to develop methods for the fabrication of well-ordered domains by controlling the in-plane molecular orientation. [12] One possible approach is to use an alignment layer for the control of molecular orientation. Several methods have been


Based on archaeological discoveries and historical materials,the history of Jinguancheng was discussed.The artistry style of Shu brocade was analyzed from the perspective of traditional patterns,and the typical artistry features were extracted.It was helpful for us to protect and inherit Shu brocade.


High energies emissions observed in X-ray binaries (XRBs), active galactic nuclei (AGNs) are linearly polarized. The prominent mechanism for X-ray is the Comptonization process. We revisit the theory for polarization in Compton scattering with unpolarized electrons, and note that the ($k \times k'$)-coordinate (in which, ($k \times k'$) acts as a $z$-axis, here $k$ and $k'$ are incident and scattered photon momentum respectively) is more convenient to describe it. Interestingly, for a fixed scattering plane the degree of polarization PD after single scattering for random oriented low-energy unpolarized incident photons is $\sim$0.3. At the scattering angle $\theta$ = 0 or $\theta \equiv$ [0,25$^o$], the modulation curve of $k'$ exhibits the same PD and PA (angle of polarization) of $k$, and even the distribution of projection of electric vector of $k'$ ($k'_e$) on perpendicular plane to the $k$ indicates same (so, an essential criteria for detector designing). We compute the polarization state in Comptonization process using Monte Carlo methods with considering a simple spherical corona. We obtain the PD of emergent photons as a function of $\theta$-angle (or alternatively, the disk inclination angle $i$) on a meridian plane (i.e., the laws of darkening, formulated by Chandrasekhar 1946) after single scattering with unpolarized incident photons. To explore the energy dependency we consider a general spectral parameter set corresponding to hard and soft states of XRBs, we find that for average scattering no. $\langle N_{sc}\rangle$ $\sim$1.1 the PD is independent of energy and PA $\sim$90$^o$ ($k'_e$ is parallel to the disk plane), and for $\langle N_{sc}\rangle$ $\sim$5 the PD value is maximum for $i$=45$^o$. We also compare the results qualitatively with observation of IXPE for five sources.


Pancasila is a formulation and guideline for the life of the nation and state for all Indonesian people. As an Indonesian citizen, implementing the values of Pancasila is mandatory because Pancasila is the basis of the state. The benefits are so that the nation's next generation can apply the values of Pancasila in their daily lives. The purpose of this study is to find out how to apply the values of Pancasila in everyday life. This research uses the literature review method. The results of this study can be concluded that the application of Pancasila values to students is mandatory, because students can take future steps in the lives of society, nation, and state to contribute to the progress of their nation and state.


In the ovary it has been demonstrated that PGF 2 a activates the phospholipase C (PLC)/diacylglycerol/protein kinase C pathway. However, little is known about the downstream signaling events that mediate subsequent cellular responses such as steroidogenesis. The present study was designed to examine the effect of PGF 2 a on acti- vation of the mitogen-activated protein kinase (MAPK) signaling pathway and its physiological role in human granulosa-luteal cells (hGLCs). Human GLCs, obtained from women undergoing in vitro fertilization-embryo transfer, were treated with increasing concen- trations of PGF 2 a (10 nmol/L to 10 m mol/L) for 5 min. For time-course experiments, hGLCs were treated with 1 m mol/L PGF 2 a for 1, 5, 10, or 20 min. Western blot analysis, using a monoclonal antibody that detected the phosphorylated forms of extracellular signal-regulated kinases 1 and 2 (p42 mapk and p44 mapk , respectively), demonstrated that PGF 2 a activated MAPK in hGLCs in a dose- and time-dependent manner. Treatment of the cells with neomycin (10 mmol/L; a PLC inhibitor), bisindolylmaleimide I (5 m mol/L; a PKC inhibitor), or PD98059 (50 m mol/L; a MEK inhibitor and a MAPK kinase inhibitor) PGF 2 a -induced activation of MAPK. In MAPK by pertussis i determine the role ofMAPKinsteroidogenesis,hGLCsweretreatedwithPGF 2 a (1 m mol/ L), hCG (1 IU/mL), or PGF 2 a plus hCG in the presence or absence of PD98059. Progesterone levels in the culture medium were examined by RIA. Treatment of hGLCs with PGF 2 a significantly inhibited hCG-induced progesterone production. The presence of the MEK inhibitor, PD98059, reversed the inhibitory effect of PGF 2 a on hCG-induced progesterone production. To our knowledge, it is the first demonstra- tion of PGF 2 a -induced activation of the MAPK signaling pathway in the human ovary. These results indicated that PGF 2 a activated MAPK subsequent to PLC and PKC activation through pertussis toxin-insensitive G protein in hGLCs. Further, we demonstrated that PGF 2 a -induced MAPK activation is associated with modulation of progesterone production. These results support the idea that the MAPK signaling pathway is involved in mediating PGF 2 a actions in the human ovary. ( J Clin Endocrinol Metab 86: 375–380, 2001)


From `86 to `96, 163 unrelated bone marrow donor (UBMD) searches for 158 children were performed in our institution. the 79 male and 79 female (pts) aged from 1 month (m) to 18 years (y) (mean: 7.2 y) at time of registration suffered from Severe Haematological Malignancies (n=108) including 69 ALL, 15 AML, 5 CML, 18 Myelodysplastic Syndroms, 1 Lymphoma; Non Malignant Hemopathies(n=23): 17 Aplastic Anaemia, 6 Fanconi; Metabolic Diseases/ID (n=27): 13 Hurler, 1 Gaucher, 2 Mucolipidosis, 1 Osteopetrosis, 6 FLH, 2 ID, 1 WA, 1 Kossman. They were eligible for a transplant procedure but the lack of family-member donor attempted us to search UBMD on international registries. The mean duration of searches was 16 m (range 9 days to 85 m). In `93, we speed the procedure to short the donor location delay reduced from 7 to 2 m(median). Eleven searches remain active today. For other pts, causes of cancellation are classified as follows: Complete Remission (CR): n=25 (17%), Deceased: n=23 (15%), Clinical status/disease progression: n=17 (11%), Allograft unrelated: n+35 (24%), Non identical Allograft Familiar: n=12 (8%), Cord blood transplantation: n=4 (3%), Autograft: n=10 (7%), Therapeutic failure/relapse (n=3), Other Causes (transfer, parents request, SAL/GCSF): n=17 (11%. All pts canceled because of disease progression died except 2 (1/2 autografted). When searches were stopped because of prolonged CR, evolution was favourable in 22/25 cases: 1 pt alive after autograft, 1 after transplant with geno id sib. born in the meantime, 1 pt died of relapse after prolonged CR of 7 y. Sixty-two patients were transplanted (39%): 35 from UBMD (3 pts transplanted twice with same UBMD), 12 from non id. familiar donor, 2 from geno-id. sibling (born in the meantime), 4 from familiar cord blood, 10 were autografted. The overall survival for unrelated BMT concerns 20/35 pts (57%): 7 ALL, 1 AML, 2 RAEBt, 1 JCML, 1 CML, 1 AA, 4 Hurler, 1 mucolip., 2 FLH. The event free survival for the 17 pts in CR with functional graft is of 59%. Among the 12 pts transplanted from non id. familiar donor, 2 are alive (1 ID/PNP, 1 FLH) but with graft failure. One patient (Hurler) transplanted with cord blood cells (HLA ½ id.) is alive but without engraftment. Four of 10 pts are alive in CR (40%). The 2 pts transplanted with geno-id brother are alive in CR. Among the 158 pts registered, 80 died (50%), 66 are alive with or without being transplanted (42%) of whom the 11 activated searches (2 BMT in progress) and 12 are lost of sight. For 3 pts who died, 1 IBMD was located too late for BMT. For 7 pts in prolonged CR, 1 or more UBMD are identified. For all high risk pts, BMT is the only therapeutic alternative and UBMD search is capital in their management.


The effects of two levels of CO 2( 375 μL/L VS 750 μL/L) on the cotton-Aphis gossypii-Lysiphlebia japonica system were studied using OTCs. We evaluated the influence of direct and indirect stress from L. japonica on the fitness response of aphids to changing CO2 for three successive generations. We wished to show whether CO2 levels,generation and L. japonica-stress markedly determined the fecundity,net reproduction,mean generation time and intrinsic rate of increase in cotton aphids,and whether interactions between these variables also had a notable impact on the fecundity,net reproduction,and intrinsic rate of increase of aphids. Our results suggest that the stress induced by exposure to caged L. japonica had greater impact on the fitness and population dynamics of successive generations of A. gossypii under elevated CO2,resulting in a lower aphid-population.


Agricultural Photovoltaic Systems are a key technology to achieve sustainable development goals by reducing competition between land for food and electricity. In addition, Agricultural Photovoltaic Systems are at the heart of the link between power generation, crop production and irrigation water conservation. The main ecophysiological constraint on crop production under photovoltaics is the reduction of light. It is difficult to recommend shade tolerance for some plant varieties due to insufficient information on shading conditions for most plants. The use of shading panels (photovoltaic panels) requires more crop-specific research to determine the optimal percentage of panels and their placement that will not reduce agricultural yields. Crop yield variation versus field shading and availability to maximize the system require extensive research. This study aims to develop a standard procedure for designing an agricultural grid-connected photovoltaic power generation system for solar power generation in an agricultural area in Bahteem, Egypt. The technical and annual performance of the grid-connected PV system was simulated using PV Syst software. The paper started with a pre-feasibility study of a grid-connected photovoltaic system using PV Syst. Software with an extensive database of meteorological data, including global daily horizontal solar irradiance, and a database of various renewable energy system components from different manufacturers. In this work, a comprehensive literature review of agricultural solar photovoltaic systems is conducted, with a particular focus on grid-connected systems, followed by a design procedure for grid-connected solar photovoltaic systems. The planned photovoltaic system will generate a total of 400 KWp of electricity. This generated electricity can drive down electricity prices by exporting excess electricity to the national grid. In addition, solar power systems are fuel-efficient and have a low environmental impact.


Background: Metabolic syndrome is a cluster of metabolic risk factors including central obesity, glucose intolerance, atherogenic dyslipidemia and hypertension. Studies have shown a prevalence of 10 - 84% in general population and 57- 92% in type 2 diabetic patients. Aims and Objectives: Our study aims to establish the prevalence of metabolic syndrome in diabetic patients at Karnataka Institute of Diabetology, Bangalore. It aims to compare the prevalence using modified NCEP-ATP III and IDF criteria, and also in women and men. Methodology: A cross-sectional study was conducted in 402 (38.6% women, 61.4% men) type 2 diabetic subjects. Fasting blood glucose, lipid profile, waist circumference and blood pressure were recorded. Modified NCEP-ATP III and IDF criteria were used to calculate the prevalence of metabolic syndrome. Results: The prevalence of metabolic syndrome was 75.1% by modified NCEP-ATP III and 68% by IDF criteria. The prevalence was 94% and 92% in women and 62% and 54% in men, by modified NCEP-ATP III and IDF criteria respectively. Hypertension was the commonest component in men, and high waist circumference was the commonest component in women. Nearly 50% had 4 components of metabolic syndrome, ≈30% had 3 components and ≈25% had all the 5 components. Conclusions: The prevalence of metabolic syndrome is very high among diabetic patients. It is higher using modified NCEP-ATP III compared to IDF criteria, especially in men. The prevalence is higher in women, due to central obesity.  Hence, all type 2 diabetic patients must be evaluated for metabolic syndrome.


A connector, in particular for connecting a hydraulic line with a coupling unit of a motor vehicle comprises a first link member having a first plug-in adapter for connecting to a first conduit. Further, a second connection part is provided, which has a second plug-in adapter for connecting a second conduit. Through the first connecting part and / or the second connecting part, an intermediate passage is formed to connect the first plug-in adapter with the second plug-in adapter, the intermediate channel obliquely, substantially at right angles, extending to the first plug-in adapter and / or the second plug-in adapter, the first connecting portion with the second connecting portion via a captive to block relative axial movement and a locking device for blocking a relative movement in the circumferential direction can be connected. By such a connector, the relative orientation of the first plug-in adapter for the second plug-in adapter in the circumferential direction can be individually adjusted and fixed, so that the mounting of a hydraulic unit with such a connector and at different engine types and / or different types of transmissions can be installed with less effort.


The acute phase response is a nonspecific and complex reaction of an organism that occurs shortly after any tissue injury. The origin of this response can be attributable to infectious, traumatic, immunologic, neoplastic, or other causes, in order to restore homeostasis, reduce tissue damage, and to remove the cause of disturbances [1]. The acute phase response is characterized by a number of different systemic effects, a range of metabolic activities and alterations in a wide variety of biochemical processes. One of the most important metabolic changes is the strongly increased (or decreased) production and secretion of some plasma proteins from the liver, the acute phase proteins [2]. The acute phase response is a very fast response, developing with increased concentrations of acute phase proteins within a few hours, which remain elevated as long as the inflammatory stimulus persists [3]. For this reason, they represent the ideal tool for the early identification of inflammation or injury, and for monitoring the outcome of disease processes. Unfortunately, acute phase proteins are poorly specific, since they increase in the presence of inflammation independent of the agent respon‐ sible, but the increase in their concentrations indicates that "something" is happening in the body, and should lead clinician to investigate the site, type and severity of the inflammation (complete clinico-pathological approach), to identify the pathogen responsible (specific diagnostic methods), and to follow-up the treatment.


An overview of the well-known methods for quantifying of river beaver (Castor fiber L.) population size has been presented in the work. The description of methods with the pointing of the possibility of their rational use and the limitation in their usage are presented. Described approaches are compared in terms of registration period, registration units, complexity of quantifying procedure and a possibility to extrapolate the gathered data.


An implicit difference scheme is proposed for the numerical solution of the equations governing the two-dimensional supersonic motion of an inviscid gas. It uses stream-lines as one of the independent variables which simplifies the treatment of the conditions at a wall and avoids the errors due to interpolating the shape of the wall. The method relies on "pseudo-viscosity" or "smoothing across the stream-lines" in order to calculate shock-waves in flow fields involving compressions. When compared with the two-dimensional flow past a wedge or with flows involving expansions (where the method of characteristic applies) the present method gives satisfactory results.


Banks as financial companies are always demanded to enhance their services to costomers, especially in terms of recommending some kinds of saving products being a suitable for the various needs and expectations of costomers. Some problems in the process of giving advice is much various of savings products based on specifications and pricing, where customers are generally less able to provide a clear specification of the requirements and expectations. One
way to solve this problem is by using fuzzy database tahani model, a model constructed though defining a given membership function whose domain represents unclear or blurred condition in the form of independent real-valued variable spanning from 0 to 1. The objectives of this case study are to find fuzzy database tahani model which are applied in determining bank savings products being suitable for the needs of prospective customers. The results showed that the query can be generated by a number of conditions in terms of with the desired attributes so that customer services can easily give recommendations to customers in
on their needs and expectations.


Key-Value SSD (KVSSD) has shown great potential for several important classes of emerging data stores due to its high throughput and low latency. When designing a key-value store with range queries, an LSM-tree is considered a better choice than a hash table due to its key ordering. However, the design space for range queries in LSM-tree-based KVSSDs has yet to be explored, despite range queries being one of the most demanding features. In this paper, we investigate the design constraints in LSM-tree-based KVSSDs from the perspective of range queries and propose three design principles. Based on these principles, we present IterKVSSD, an Iterator interface extended LSM-tree-based KVSSD for range queries. We implement IterKVSSD on OpenSSD Cosmos+, and our evaluation shows that it increases range query throughput by up to 4.13× and 7.22× for random and sequential key distributions, respectively, compared to existing KVSSDs.


The aim of this study is to acquire a better understanding of how natural history(NH) and natural history museums(NHM) are perceived among students, teachers and parents by administering a questionnaire. A total of over 2500 people participated in this survey. We developed the questionnaire which was categorized by three specific areas: 1) people's overall perceptions of natural history and natural history museums; 2)the way of people's getting such perceptions and knowledge; 3) people's possessing interests in NH and NHM. The summary of survey results included; firstly people had paid attention to nature and natural environments; secondly NH and NHM were not familiar to people, but they expressed their eagerness to learn about them; thirdly the first image occurred to people was dinosaur, when they recalled NH and NHM with describing them to be mysterious and education.; on the fourth, NH and NHM were informed through TV programs; lastly, most people responded that they never learned about NH and NHM in schools but they wanted to learn them.


Arsenic removal from aqueous solutions containing hexafluoroarsenate or arsenate by strong and weak base anion exchangers was studied by dynamic column tests that were carried out using solution containing arsenic and accompanying anions (chlorides, sulfates and fluorides). The specific flow rate of solution was 6 BV/h. Desorption of arsenic was carried out by 1 mol/L NaOH or 2 mol/L KSCN. All the studied anion exchangers performed well in the absence of accompanying anions. In the presence of chlorides and sulfates, studied exchangers showed high selectivity towards hexafluoroarsenate.


Nowadays, the system of university is increasingly reformed. The mode of management is in the process of escalating and the economic activity is increasing. Internal audit plays an increasingly important role, but there are some shortcomings and hidden danger in current internal audit of colleges and universities. This needs us to make research on the internal audit externalization to improve the quality of internal audit. This paper focuses on the SWOT analysis of internal audit externalization in colleges and universities. It will simply illustrate the strengths, weaknesses, opportunities and threats of the internal audit externalization and analyze every aspect. Finally, the author will provide some strategies in the internal audit externalization on weaknesses and threats, hoping it will have a certain guiding role in practice and better develop internal audit externalization.


tag=1 data=Youth crime backlash. by Victoria Laurie

tag=2 data=Laurie, Victoria

tag=3 data=The Bulletin,

tag=6 data=10 March 1992

tag=7 data=24.

tag=8 data=JUVENILE DELINQUENCY%WA

tag=10 data=The legal fraternity in Western Australia is launching a bid to dump controversial new anti-juvenile legislation.

tag=11 data=1992/4/4

tag=12 data=92/0233

tag=13 data=CAB


To develop a conceptual research framework to identify the factors that influence Corporate Community Development (CCD), leading to beneficiary satisfaction in the context of Islamic banks in Bangladesh (IBB). This study attempts to explore the outcomes of beneficiary satisfaction from the contribution of CCD practices. From extensive literature review, this research framework is developed by integrating institutional theory and associate research agenda. Relevant literature has indicated the relation between the constructs of institutional theory and CCD. Empirical evidence of literature also shows a direct relationship between CCD practices and beneficiary satisfaction. All evidence supports CCD as a mediator between predictors and outcome (beneficiary satisfaction). Thus, this study attempts to develop a model to explain CCD and beneficiary satisfaction with regard to institutional theory perspective. From the obtained data, CCD may be used to better understand the cooperation enhancement of community and provide them with effective information and method to increase beneficiaries' satisfaction. CCD practices of IBB remain questionable. Therefore, the sustainable development and harmony relations between corporation and community will help solve unclear ideas about community development (CD) practices in CCD segment. In this study, the framework ensures its originality value due to its great significance. It contributes to scarce literature on CCD in IBB by analyzing the way that institutional theories in the country contribute to CD. This study will benefit CD practitioners, CCD providers and academician researchers.


Teleconsultation and telemedicine are the application and development of the telecommunication networks. Health experts can solve problems by using the electronic and communication technologies without distance limitation. In this study, we try to develop the teleconsultation and telemedicine system between earthquake local site and consulting experts site. The system at each site has a workstation including a cable modem or ADSL connection, a monitor, a web camera, speakers, a microphone for communication, and NetMeeting application software. In addition, this study intends to develop a school-based intervention program by using this system for high-risk school-age children in one of the earthquake-struck areas. The preliminary result of this study is that the teleconsultation and telemedicine system is more effective than traditional consultation and supervision. Moreover, we can apply this system in training local volunteers, educators, and welfare workers. Meanwhile, we can save lots of cost and time since we don't need to travel between the local site and the expert site. In the end of this study, the application of this system in SARS case treatment and the network application of this system in psychiatric counseling were also discussed.


. In this article we explore an arithmetic analogue of a long-standing open problem in graph theory: what can be said about the number of monochromatic additive configur-ations in 2-colourings of finite abelian groups? We are able to answer several instances of this question using techniques from additive combinatorics and quadratic Fourier analysis. However, the main purpose of this paper is to advertise this sphere of problems and to put forward a number of concrete questions and conjectures.


The woolen fabrics relics unearthed in Xinjiang have always drawn double attention of domestic and foreign professionals, which have been carrying out a series of research works in the region from the past till nowadays. With the development of the society and the progress of science and technologies, the archeological and cultural relics of Xinjiang have also gradually come to the world, on which the research cooperation between Chinese and foreign professionals also grows. Archeology in Xinjiang fabric relics has also made great achievements. With the devoted work of these experts and scholars, a large number of fabric relics unearthed in Xinjiang have the chance to be presented to the world. Through their research, I have a more comprehensive understanding of the ancient woolen fabrics unearthed in Xinjiang, as well as the patterns, historical and cultural background. It provides technical and artistic guidance on the contents, objectives and scope of the research topics.


ABSTRACT Higher heat input rates and uneven thermal cycles involved in fusion welding processes effect HAZ properties and causes to develop residual stress across fusion zones. These thermal stresses reduce the service life of welded structures. To understand the thermal cycles, In-Situ peak temperatures and their distribution over the weld surface of similar and dissimilar combinations of Monel 400 and AISI 316 base plates joined by constant and pulsed current TIG welding processes are measured with Infrared thermography technique at different time intervals. After welding the joints, thermal stresses developed across the joints were measured using X-ray diffraction technique. The stress measurements were made on weld surfaces of fusion zone and HAZ on either side of base metals. Higher temperature values were recorded during constant welding technique than the pulsed welding technique. Also, the heat affected area was more in weldments of constant welding technique. The maximum temperatures of 1657 0C, 1711 0C and 1748 0C were recorded in CCGTAW process during pass-1, pass-2 and pass-3 welding, respectively. Whereas, in PCGTAW process, maximum temperatures of 1434 0C, 1509 0C and 1634 0C were recorded during pass-1, pass-2 and pass-3 welding, respectively. The overall reduction in temperatures in PCGTAW process was 10.6%, which could affect the cooling cycles during solidification. Both the welding techniques have exhibited development of compressive natured residual stresses in dissimilar joints. The heat concentration at fusion area was reduced in pulsed technique that resulted in lower residual stresses.


The skin is the largest organ of the human body and it known as the integument or integumentary system because it covers the entire outside of the body. The skin consists of two main layers: the outer layer, or epidermis, which lies on and is nourished by the thicker inner layer, or dermis.. These two layers are approximately 0.04–0.08 in (1–2 mm) thick. The epidermis consists of an outer layer of dead cells called keratinocytes, which provide a tough protective coating, and several layers of rapidly dividing cells just beneath the keratinocytes. The dermis contains the blood vessels, nerves, sweat glands, hair follicles, and oil glands. The dermis consists mainly of connective tissue, which is largely made up of a protein called collagen. Collagen gives the skin its flexibility and provides structural support. The fibroblasts are the main cell type in the dermis and make collagen. Skin varies in thickness in different parts of the body; it is thickest on the palms and soles of the feet, and thinnest on the eyelids. In general, men have thicker skin than women, and adults have thicker skin than children. After age 50, the skin begins to grow thinner again as it loses its elastic fibers and some of its fluid content. A skin graft is used permanently replace damaged missing skin or provide a temporary wound covering. Skin is necessary because it protects the body against Fluid loss, bacteria or virus invasion, and aids in temperature regulation. Skin that is damaged extensively by burns or non-healing wound can compromise an individual's health and well-being. Skin grafting is the next step on the reconstructive ladder for the closure of a wound that cannot be closed primarily. Skin grafts are classified as either split-thickness or full-thickness, depending on the amount of dermis included in the graft. A partial or split-thickness skin graft (STSG) contains a variable thickness of dermis, while a full-thickness skin graft (FTSG) contains the entire dermis. Split-thickness skin grafts are further categorized as thin (0.005-0.012 in), intermediate (0.012-0.018 in), or thick (0.018-0.030 in) based on the thickness of the graft harvested. Skin grafting serves two purposes: reduce the course of treatment and improves function and appearance of the recipient area.


A field evaluation of a new size-fractionating continuous fine particle nitrate monitor from Aerosol Dynamics Inc. (ADI), Berkeley, CA was conducted via comparison to traditional time-integrated filter (HEADS) and impactor (MOUDI) measurements. The new monitor consists of three cascaded integrated collection and vaporization cells (ICVC) and provides 10-min resolution particulate nitrate measurements in three particle diameter size ranges (0.10-0.45, 0.45-1.0, and 1.0-2.5 w m) corresponding to observed submodes in the particle size distribution in Southern California. Side-by-side sampling was conducted for approximately six months at two sites, both at downwind receptor locations east of downtown Los Angeles. Both size-resolved and total PM 2.5 nitrate concentrations were compared among the different sampling techniques. The ADI monitor and HEADS PM 2.5 nitrate measurements, for which nitrate sampling artifacts are expected to be low, are well correlated (r 2 = 0.79) with a geometric mean ADI:HEADS ratio of 0.90. The ADI size-fractionated nitrate data measured consistently more nitrate than the corresponding MOUDI stages due to volatilization of labile ammonium nitrate from the MOUDI impaction substrates. Less disagreement was observed in the 1.0-2.5 w m size range in which nitrate is more likely to exist as nonlabile sodium nitrate. The observed MOUDI nitrate losses are attributable to existing theories of nitrate sampling efficiencies and losses. The continuous nature of the data generated by the ADI monitor will provide valuable information on the spatial and temporal distribution of particulate nitrate in the atmosphere, and the new dimension of size-fractionation can help to determine the sources and formation mechanisms of atmospheric particulate nitrate as well. Examples of the atmospheric data generated in this study are presented and the potential utility of such data provided by the new monitor are discussed.


Objective: To evaluate occlusal rest seat preparations for cobalt chromium cast removable partial denture.
Materials and Methods: A cross-sectional study was carried out in the department of Prosthodontics, Khyber College of Dentistry, Peshawar starting from June 2014 to June 2015 using consecutive non-probability sampling technique. Data was collected from 127 partially dentate patients having a bounded saddle with a distal abutment as second molar with normal occlusal surface morphology and mesio-occlusal rest seats prepared on the mentioned molar teeth. Patients having partially dentate areas with no principal abutment as second molar and rest seat other than mesio-occlusal rest seat were excluded from the study. Casts were evaluated for aspects of rest seat like the general outline form of the rest seat (visually assessed from the casts), the bucco-lingual and mesio-distal dimensions were measured using a divider and scale. Depth of the rest seat was measured by placing a piece of warm modelling wax with the casts in occlusion and measuring the thickness using Iwenson gauge. Data was analyzed using SPSS 20.
Results: Out of 127 patients, mean age recorded was 38 years with Standard deviation ± 2.15. Males (62%, n=79) reported more than females (38%, n=48). The most frequently reported inadequate dimension was the depth of rest seat (46%, n=58), followed by the general outline form and mesio-distal width (40%, n= 51). The bucco-lingual dimension was recorded to be inadequate in 37% (n=47) of the cases.
Conclusion: Most of The participants tend to under-prepare rest seat in terms of outline form, width, length and depth.


Initially two experiments were performed on eight subjects to determine the effect of semantic content or meaning of a competing speech message on the identification of synthetic sentence material....


The annual growth in the number of people living with HIV infection inevitably leads to an increase in the number of cases of any type of comorbidity. The article analyzes modern epidemiological, clinical, therapeutic aspects of anogenital herpes simplex virus infection (AHVI) in HIV-positive patients. Human immunodeficiency virus (HIV) and herpes simplex virus 2 (HSV-2) combine epidemiological and biological synergy. Concomitant anogenital herpes increases the risk of HIV infection by 2.7-4.7 times, and also contributes to its transmission through unprotected sexual intercourse. In HIV-infected patients with AHVI, the genital excretion of HSV-2 is increased. Among HIV-positive individuals, the seroprevalence of HSV-2 exceeds the population figures by 1.9-3.8 times. The incidence of AHVI in a cohort of Russians with a positive HIV status is 5-7.8 times higher than in the general population. The review demonstrates that both infections can have a negative mutual influence on the clinical course of each other. Particular emphasis is placed on the timely diagnosis of cases of coinfection. Based on the current regulatory documents, the authors developed and presented an algorithm for testing for HIV in patients with a newly diagnosed anogenital herpes.


A challenge for quality management is to develop agreed upon standards for quality with clear, concise definitions. There are many technical issues that also need focus; for example, "Are quality, reliability, and performance so tightly linked that they can be treated as one  interchangeable  concept?"  In  addition, recently proposed IEC standards address both hardware and software for reliability growth along with a tri-modal model for IC reliability. Standards are also available for availability testing on a system basis with or without downtime constraints. Thus, a move away from the hardware on ly quality management philosophy will surely drive the Quality of the Systems upward as the integrated hardware, software, and human performance design considerations are developed and are standardized in the drive for quality.


The choice of administrative regulation mode of surrogacy directly influences, and even decides, the effect of surrogacy regulation. At present, there are mainly three administrative regulation modes of surrogacy worldwide, which are completely prohibited mode, limited open mode and non-uniformly regulated mode. The completely prohibited mode adopted by China's current administrative regulation concerning surrogacy doesn't go against the basic principle of administrative regulation, and on the contrary, it is a reasonable administrative regulation mode respecting more of humanity, being fully conforming to China's national conditions. However, out of the need to regulate surrogacy more effectively, China's current surrogacy regulation needs to be further improved in system design.


We wish to apologize for suggesting that a pharmacist might comment disparagingly on a prescription for a placebo. We should not have imputed such unethical conduct to members of the pharmaceutical profession.


Data usually evolve according to specific processes, with the consequent possibility to identify a profile of evolution: the values it may assume, the frequencies at which it changes, the temporal variation in relation to other data, or other constraints that are directly connected to the reference domain. A violation of these conditions could be the signal of different menaces that threat the system, as well as: attempts of a tampering or a cyber attack, a failure in the system operation, a bug in the applications which manage the life cycle of data. To detect such violations is not straightforward as processes could be unknown or hard to extract. In this paper we propose an approach to model the data life cycle by observing the data evolution in its life cycle. Thus, we represent users able to alter data through timed automata. Through model checking, the obtained profile of evolution can be used to detect anomalies in relational database, data warehouse and big data.


Simulated annealing and isolation niche are two helpful methods that can improve performance of genetic algorithm. These two ideas are well combined in this paper, at the same time, production mode of initial population, crossover operator and mutation operator are improved by using the global equilibrium design ideology of orthogonal experiment method and dual mutation operation. On this basis, a new algorithm is derived, that is isolation niche hybrid genetic algorithm based on simulated annealing method. The research results show that this method can not only improve the convergence efficiency, but also evidently improve the computation speed.


Human mitochondrial DNA (mtDNA) has higher polimorfism level than nucleous genom, especially in the D-Loop region, which is a non coding region and the most polymorfic region in the mitochondrial genom. The analysis of variation of nucleotide sequence of D-Loop region can be used to determine the individual or ethnic identity and also maternal familiar relationship. The research aims to determine nucleotide variant on Balinese individue, which can be used as data base in determination of mtDNA genetical profile of Balinese ethnic in a bigger scale. To achieve the aims of the research, way the nucleotide sequence of one normal Balinese individue using the epithelia cells in the saliva. The methods were :1) the isolation of sample mtDNA, 2) the amplification of the DLoop region of mtDNA by PCR, 3) sequencing and analysis of nucleotides sequence. The 0,4 kb fragment of the D-loop region mtDNA of the sample were successfully amplified, and sequenced of 402 pb. The research found 6 new variants or morfe different from Cambridge or Anderson sequence : variant 16223C®T, 16249T®C, 16259C®T, 16278C®T, 16316A®G, 16375C®A. The research also found the deletion of T nucleotide on position 16362.