The purpose of the paper is to investigate the status of cultivated land conservation and labor migration in six villages of Daqing City,to analyze the relationship between them,and further to discuss the existing problems.Methods of questionnaire investigation and comparative analysis were employed.The results indicate that 1) the cultivated land conservation behavior was affected by income level of farmers;2) there is bigger gap between the existing farmers' income and the threshold returns of cultivated land conservation;3) an important approach of improving farmers' income is to achieve the agricultural operation scale;4) the new channels need to be opened up for transferring the surplus agricultural labor.In conclusion,one of the important ways to realize cultivated land conservation is to improve farmers' income to reach the threshold returns of cultivated land conservation through transferring surplus agricultural labors so as to achieve the scale efficiency of agricultural operation.


Objective: Hypertension is recognized as a major contributor to the disease burden globally. Hypertension and its complications account for an estimated 9.4 million deaths every year.1 Thereby, the present study was aimed to find out prevalence of hypertension and to identify the risk factors associated amongst rural population aged 18 years and above who attended the Out Patients Department of Tertiary Care Hospital of Trivandrum district Kerala. Design and Method: Qantitative descriptive study design. The study was carried out among adults aged 18 years and above attending outpatient departments (OPD). Simple random sampling was used to select the study subjects. A structured pretested and predesigned questionnaire was used to assess study subjects' self-reported behavioral and lifestyle risk factors (Smoking, tobacco use, alcohol consumption, diabetes mellitus, dyslipidemia and known hypertension) , for hypertension, the measurement of subject's blood pressure and BMI was estimated by anthropometrical parameters. Results: The study findings reveals that majority 398 (36.5%) belongs to 46–60yrs. Majority 641 (58.9%) were females. Among the subjects 78 (7.2%) have the habit of betel chewing and 80 (7.3%) were reported as smokers. The findings shows that 217 (19.9%) are known diabetes mellitus, 183 (16.8%) have hyperlipidemia, 240 (22%) are known hypertensive and 32 (2.9%) have cardiac disease. Data shows that 147 (13.5%) are obese and 385 (35.4%) were overweight. Prevalence of hypertension shows that majority 526 (48.3%) are normotensive, 252 (23%) belongs prehypertensives, 240 (22%) are stage I hypertensive and least 71 (6.5%) are stage II hypertensive (fig.1). Prevalence of hypertension is highest among females ie.641 (58.9%). Prevalence of hypertension shows highly significant (p < 0.05) association with age, gender, diabetes mellitus, dyslipidemia, known hypertension and body mass index. Conclusions: The prevalence rate of hypertension was 28.5%. The prevalence rate was higher (58.9%) among females. Increase in age, smoking, chewing tobacco, obesity, and diabetes mellitus have been found to have association.


C. arabica accessions conserved in the CATIE genebank were classified in three groups on the basis of their genetic origins: coffee trees from the centre of origin of the species ; Typica- and Bourbon-derived varieties and mutants ; and introgressed lines selected within interspecific hybrid progeny (C. arabica x Coffea spp.). The results of the assessment and characterization of these resources highlighted features specific to each of these groups with respect to their innate genetic diversity and extent of polymorphism. The genetic resource assessment data discussed in this chapter could now be used to build core collections for long-term germplasm conservation, evaluation and exchange purposes


While major depression tends to be a relapsing and recurrent disorder, indefinite drug therapy is often undesirable because of side effects and


We develop the total effective Lagrangian of the two-photon couplings to the color-singlet neutral pseudo-Goldstone boson P0, as predicted in technicolor models. We calculate the effect of t-quark loop on the coupling. Such effect significantly changes the coupling strength which ordinarily arise from the Wess-Zumino term.


Introduction: Telomere Biology Disorders (TBD) are due to germline variants in telomere maintenance and repair genes. Clinical manifestations include bone marrow failure (BMF), liver and lung fibrosis, and risk of cancer, especially myeloid neoplasia. We characterized clinical phenotype, pathology, and clonal landscape of patients with TBD and myelodysplastic syndrome (MDS) or acute leukemia (AL). We assessed if somatic variants in myeloid cancer genes are associated with MDS/AL or overall survival (OS).
 Methods: Patients (n=109) from the National Institutes of Health and University of São Paulo (NIH/USP) (n=91) or MD Anderson (MDA) (n=18) met TBD clinical criteria or had a pathogenic/likely pathogenic germline variant in a telomere maintenance/repair gene. All patients gave informed consent. Clinical characteristics and details of hematologic malignancy were collected. MDS was defined using WHO 2016 criteria. In the NIH/USP cohort, somatic variants in myeloid cancer genes were assessed in peripheral blood using error-corrected DNA sequencing (ECS; minimum variant allele frequency [VAF] of 0.5%) and in the MDA cohort patients were screened by targeted amplicon-based next-generation sequencing (minimum VAF of 2%). Serial samples were available in 31 (41%) patients.
 Results: Eighteen out of 109 (17%) patients from both the NIH/USP and MDA cohorts had a diagnosis of MDS/AL, developing in patients with TERC (n=8/31; 25%), TERT (n=8/48; 16%), RTEL1 (n=1/5; 20%), and DKC1 (n=1/2; 50%). Karyotypes were normal diploid (n=6), chromosome 1 abnormality (n=5), trisomy 8 (n=2), deletion 20q (n=1), complex (n=2), monosomy 7 (n=1) and deletion 7q (n=1). Six patients had >5% blasts. Four patients had concurrent liver fibrosis and 9 had pulmonary fibrosis. Somatic mutation data at time of MDS/AL was available for 16/18 patients; splicing factor genes (n=14) were most frequent, seen in 11 (69%) patients, with U2AF1 predominating (n=7; 44% of patients) (Figure 1A). More than 1 mutation was present in 12/16 (75%) of patients. One patient developed AML 6 years after MDS diagnosis . U2AF1 variants were also present in 8 patients without MDS/AL; 5 had no sequential samples and 3 had stable mutations over 2 (n=2) and 4 (n=1) years. Recurrent variants in U2AF1 were present at p.S34 (n=12) and p.Q157 (n=2). Median U2AF1 variant allele fraction (measured in NIH/USP cohort only) was 23% in patients with MDS/AL compared to 7% in those without.
 Variant association analysis was confined to NIH/USP cohort due to DNA sequencing assay differences; data were available in 75 patients. Patients were divided into groups defined by specific variants at any time of sampling; "Clonal-hematopoiesis of indeterminate potential / aplastic anemia (CHIP/AA) associated" (DNMT3A, TET2, ASXLI, or BCOR/L1), "MDS-associated" (containing splicing factor genes, RUNX1, SETBP1, ETV1, KRAS, STAG2, GATA2/1, TP53), "PPM1D" (containing PPM1D), and a subgroup, "Splicing factors" (U2AF1, ZRSR2, SF3B1, SRSF2). Patients with MDS-associated variants (Figure 1A; p=0.02), particularly splicing factors (Figure 1B; p=0.007) more likely had or later developed MDS/AL, compared to patients without somatic variants or in other variant groups. MDS/AL was not associated with PPM1D or CHIP/AA-associated variants. OS from time of first detected somatic variant was lower in the MDS-associated variant group (Figure 1C p=0.013) compared to those without variants at time of first assessment; this was not the case for CHIP/AA-associated variants or PPM1D. Patients with somatic variants (median ages 36, 41, and 42 for PPM1D, CHIP/AA-associated, and MDS-associated respectively) were significantly older than patients without variants (median age 24) though ages were similar within variant groups.
 Conclusion: Splicing factor gene variants predominate the clonal landscape of TBD-associated hematologic malignancy; U2AF1 p.S34 is recurrent and can occur in the absence of neoplasia. Splicing factor gene variants such as U2AF1 in the peripheral blood may be potential biomarkers for hematologic malignancy in TBD patients. PPM1D, previously associated with therapy-related MDS, is commonly mutated in TBD but does not associate with MDS/AL. OS was decreased in patients with MDS-associated variants but not with PPM1D or CHIP/AA-associated variants. Further study of U2AF1 variants in TBD patients may give insight to the underlying drivers of MDS/AL.
 Figure 1 Figure 1.

 DiNardo: Agios/Servier: Consultancy, Honoraria, Research Funding; Notable Labs: Current holder of stock options in a privately-held company, Membership on an entity's Board of Directors or advisory committees; ImmuneOnc: Honoraria, Research Funding; Bristol Myers Squibb: Honoraria, Research Funding; AbbVie: Consultancy, Research Funding; Forma: Honoraria, Research Funding; GlaxoSmithKline: Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria; Takeda: Honoraria; Foghorn: Honoraria, Research Funding; Celgene, a Bristol Myers Squibb company: Honoraria, Research Funding. Calado: Novartis Brasil: Honoraria; Instituto Butantan: Consultancy; AA&MDS International Foundation: Research Funding; Alexion Brasil: Consultancy; Agios: Membership on an entity's Board of Directors or advisory committees; Team Telomere, Inc.: Membership on an entity's Board of Directors or advisory committees. Young: Novartis: Research Funding.


In view of the deficiency in methods for choosing zonation indicators of mudflow danger degrees,a new method for choosing zonation indicators of mudflow danger degrees is put forward based on the rough set theory in this paper.Firstly,according to the environmental conditions of forming mudflows,an indicator choice system is established.Then the indicators for choice are discretized by indicator grading.Finally,based on the discernable matrix of the rough set,a core set of the indicators is found and the representative indicators are sieved out.The examples show that this method is easy to operate and considers both representativeness and comprehensiveness.


Mental disorders are manifestations of behavioral deviations due to emotional distortion. It is also defined as the irregularities in behavior, which occurs due to the decline in all psychiatric functions. Therefore, the existence of these deviations caused People with Mental Disorders (ODGJ) to be treated differently, and are often called crazy. One form of treatment inequality that leads to wrong actions in dealing with ODGJ is the shackling practice. Data obtained from the Indonesian Ministry of Health in 2013, showed that 1.7% out of 1,000 Indonesians have experienced schizophernia or psychosis, while approximately 14.8% had been shackled in their lives using ODGJ. The large number of ODGJs in Bali Province shows that there is a need for appropriate handling from both the government and the community. The problem faced by the family ODGJ people includes economical and social factors. Stigma in the community of people with mental disorders also complicates the comprehensive handling process. Goffman in Lestari stated that stigma on people with mental disorders has two main components. Based on these problems, a community service is conducted to provide education related to the handling of ODGJ. It automatically helps to eliminate stigma in the community and helps families with ODGJ members in handling them independently.


Slash-and-burn rice production systems in the hilly areas of Laos have changed little over the past decades except for a reduction in the fallow period which has caused a tremendous increase in labor requirements for weed control. From 1950 to 1990, the population density increased from 7.6 to 17.6 persons/km2, fallow periods decreased from 38 to 5 years, and weeding requirements increased from 1.9 to 3.9 weedings/rice crop. Because of high requirements for weeding, the return to labor is only 5 kg rice/labor day for slash-and-burn systems compared with 13 kg/day in lowland rice production. Soil organic C levels are declining fast, with losses of 5 t/ha observed during a single rice crop. Improvements of the living standard of the farm population, food security, stabilization of upland agriculture, and increased rice production are the main objectives of development agencies working in hilly areas. However, the options available are limited by the market opportunities and there is little chance that any of the technologies offered will be adopted on a significant scale. Hill farmers have a comparative advantage for livestock and timber production but generally lack the necessary resources to make long-term investments in either operation. Market, credit opportunities, and land tenure are key factors affecting the direction of future hill agriculture in Laos.


The zero-velocity update (ZUPT) method is an effective technique, which has been widely used in low-cost foot-mounted inertial navigation systems. It can mitigate the accumulated error by using the fact that, when the foot is stationary, the velocity should be zero. However, it is hard to detect the zero-velocity phases (ZVPs) correctly in various motion modes. To deal with this problem, a novel adaptive zero velocity detection algorithm based on an improved general likelihood ratio test (IGLRT) detector is proposed. The prior knowledge of the proposed IGLRT detector is the minima output value of inertial sensors, which is determined by an improved peak-valley detection method, while the prior knowledge of the traditional general likelihood ratio test (GLRT) method is based on the hypothesis that, when the foot is stationary, the magnitude of angular rates is zero, and the magnitude of accelerometers is equal to the magnitude of gravitation. Also, an adaptive method is proposed to enhance the robustness of the IGLRT, where the thresholds of IGLRT can be adjusted adaptively according to the amplitude of accelerometers. Field tests show that the proposed algorithm performs better than conventional and state-of-the-art approaches in mixed motion modes.


The ring-core refractive-index profile in RO-Al2O3-SiO2 glass (R = Ca and Ba) was formed by the manipulation of a platinum (Pt) microsphere via continuous-wave laser irradiation method (the CW-LM3 method). The homogeneously modified area could be obtained in the CAS glass (R = Ca) with a wide velocity of the microsphere, though the BAS glass (R = Ba) showed inhomogeneous modified area with periodic structure. The even-width modified line was fabricated by controlling the velocity of the Pt microsphere, and the ring-core structure with the highest refractive index change was fabricated in the CAS glass with the Pt-microsphere speed of 46 μm/sec.


Fog computing is an advanced technique to enhance the Quality of Service (QoS), decrease network latency and energy consumption for Internet-of-Things devices (IDs). In this article, to minimize the overhead of the fog computing network, including the task process delay and energy consumption, while ensuring multiply QoS requirements of different types of IDs, we propose a QoS-aware resource allocation scheme, which jointly considers the association between fog nodes (FNs) and IDs, transmission and computing resource allocation to optimize the offloading decisions while minimizing the network overhead. First, an analytic hierarchy process-based evaluation framework is established to find the preference of QoS parameters and the priority of different types of ID tasks. Second, we introduce a resource block (RB) allocation algorithm to allocate RBs to IDs based on the IDs priority, satisfaction degree, and the quality of RBs. Moreover, a QoS-aware bilateral matching game is introduced to optimize the association between FNs and IDs. Finally, the offloading decisions are based on the previous steps to minimize the network overhead. The simulation results demonstrate that the proposed scheme could efficiently ensure the loading balance of the network, improve the RB utilization, and reduce the network overhead.


As awareness of human-made environmental harm is increasingly acknowledged, going green is becoming more popular. Behavioral research is increasingly focused on how individuals are influenced to co...


Today society is full of realities which are interpreted by media, by government, by people themselves and so on. The question arises what is real and not misnomer because everything seems illusory. Things are articulated and manipulated with or without statistics whose authenticity is questioned.
Everyone is like sheep on media; one person starts making noise and everyone like hey!Yeah, and then you got a whole bunch of people making noise at you


From ancient to modern times, acoustic structures have been used to control the propagation of acoustic waves. However, the design of acoustic structures has remained a time-consuming and computational resource-consuming iterative process. In recent years, deep learning has attracted unprecedented attention for its ability to tackle hard problems with large datasets, achieving state-of-the-art results in various tasks. In this work, an acoustic structure design method is proposed based on deep learning. Taking the design of multiorder Helmholtz resonator as an example, we experimentally demonstrate the effectiveness of the proposed method. Our method is not only able to give a very accurate prediction of the geometry of acoustic structures with multiple strong-coupling parameters, but also capable of improving the performance of evolutionary approaches in optimization for a desired property. Compared with the conventional numerical methods, our method is more efficient, universal and automatic, and it has a wide range of potential applications, such as speech enhancement, sound absorption and insulation.


Background. In the airways, the CFTR genetic defect leads to dysregulation of inflammatory and iron homeostasis that precedes bacterial infection that, in turn, worsens host damage. Lactoferrin (Lf), an iron-chelating glycoprotein of the innate immunity present in airway secretions and secreted by neutrophils in infection/inflammation sites, in addition to the well-known antibacterial activity exerts a key role in inflammatory and iron homeostasis.


The purpose of this research is to find out the influence of education, work experience, contract work system and HR management on the quality of pt. Srikandi Mandiri Duta Mulia. The research method used in this study is descriptive quantitative by using a statistical correlation of multiple regressions. Popolasi in this study is the entire workforce available at PT. Srikandi Mandiri Duta Mulia, with a sample of 53 respondents. The results stated that education, work experience, contract work systems and HR management have a positive influence both partially and simultaneously on the quality of the workforce.
 Keywords: education, work experience, contract work system, HR management, Quality of work.


The IEEE 802.15.4 standard is a rapidly growing technology for short-range communications and low rate Wireless personal area networking. The standard has been widely accepted as the de facto standard for wireless sensor network (WSN) because of its low cost deployment and remarkable applications. The mobility management in the existing WSN has highly suffered from different issues like high packet loss and delay because the current mobility management in IEEE 802.15.4 lacks the support of handover management for real-time streaming applications. In this paper, we propose a new fast handoff mechanism which eradicates the scanning delay. The proposed scheme uses the information of link quality (LQ) of the neighboring coordinators (COs), and on the basis of this information it selects an appropriate CO for handoff. The proposed scheme is evaluated through extensive simulations which show its strength and accuracy in the context of switching of high streaming data from one CO to another.


The International Electrotechnical Commission (IEC) 947-4-1 standard requirements to claim compliance with type 2 coordination are explained. The history and benefits of type 2 coordination are described. For simplicity, this work focuses on type 2 coordination as it relates to fuses and magnetic starters installed in any typical industrial control panel which may include a fusible disconnect switch, motor starters, control relays, push buttons, etc.<<ETX>>


This study aims to contribute to the understanding of the concept and implementation of the Balanced Scorecard (BSC), in a cooperative environment. The study is focused on analyzing the use of BSC for evaluation and performance in a cooperative organization characterized in a case study, descriptive and qualitative. Finally, it was noted that the cooperative has alignment between their practices and what is recommended in the literature by Kaplan and Norton. Analyzing the basic principles of BSC, as Kaplan and Norton (2000), with the development of the BSC in the cooperative was concluded that the Cooperative is working properly, as envisaged in the literature review searched the Balanced Scorecard.


At present,the existence of non-state-owned enterprises in China shows its inevitability and the rationality.The law of value still plays a role as adjustment to the socialist market economy.Capitals,techniques and invisible capitals as productive elements taking shares in distribution is based on recognition of labor theory of value.The capitals ,techniques and invisible capitals in non-state-owned enterprises combined with labor provide society with commodities,employments,taxes and bear responsibilities.Therefore,they should be given a status as a principle part in market,more suitable environment for development,and equal treatment and protection by law.


: Objective To explore the effect of teach - back method on exercise compliance and quality of life in elderly patients with hemiplegia after stroke. Method Using the convenient sampling method , a total of 80 elderly patients with hemiplegia after stroke were randomly divid⁃ ed into control group ( n = 40 ) and intervention group ( n = 40 ) . The control group adopted the routine health education method , and the intervention group adopted the teach - back method on the basis of routine care. After a 3 - month follow - up , the rehabilitation exercise compliance scale , Na⁃ tional Institutes of Health Stroke Scale ( NIHSS ) score , Fugl - Meyer Assessment ( FMA ), Modi⁃ fied Barthel Index scale ( MBI ) and Stroke Specific Quality of Life Scale ( SS - QOL ) were used to compare the effects of exercise compliance , neurological function , limb motor function , self - care ability and quality of life between the two groups. Results The compliance rate was 85 . 00 % ( 34 / 40 ) in the intervention group , which was significant higher than 72 . 50 % ( 29 / 40 ) in the control group ( P < 0 . 01 ) . The NIHSS score decreased in both two groups after intervention , and NIHSS


ABSTRACT ABEC™-5000, an aqueous biphasic extraction chromatography resin consisting of monomethylated polyethylene glycol (PEG)-5000 covalently bound to a polystyrene support, was investigated for its ability to remove pertechnetate from simulated Hanford tank wastes. Retention of TcO4 − on the resin in batch mode from 2 and 4 M NaOH and from the waste simulants NCAW, SY-101, and SST, indicated that pertechnetate can be selectively removed from these solutions. Column studies were conducted with 4 M NaOH and the NCAW simulant spiked with Na99mmTcO4 or Na95mMmTcO4. The columns can be easily stripped using water, thus concentrating the pertechnetate. The effects of several matrix ions present in the Hanford tanks were investigated. It was found that nitrite and nitrate lower the retention of TcO4 −, while citrate, carbonate, and aluminate enhance the retention. It was also observed that raising the temperature from 25 °C to 40 °C has little effect on retention. Radiation stability studies indicate that ABEC...


Cancer is one of the major problem today, diagnosing cancer in earlier stage is still challenging for doctors. Breast cancer is one of the major death causing diseases of the women today all over the world. Every year more than million women are diagnosed with breast cancer worldwide over half of them will die because of the late diagnosing of the disease. So many researches have undergone for detecting the cancer based on data mining technology each approach has its own limitations. This makes us to take up this problem and to implement the Data mining based cancer prediction System (DMBCPS). We have proposed this cancer prediction system based on data mining technology. This system estimates the risk of the breast cancer in the earlier stage. This system is validated by comparing its predicted results with patient's prior medical information and it was analyzed by using weka system. The main aim of this model is to provide the earlier warning to the users, and it is also cost efficient to the user.


Objective To study the treatment effect of flavonoid Rutin on acute gouty arthritis(GA) in the animal model of monosodium urate monohydrate(MSU) crystal-induced inflammations.Methods Forty-eight healthy female SD rats were enrolled and equally randomized to six groups: blank control(group A),model(group B),Indometacin group(group C),low-Rutin group(group D) and middle-Rutin group(group E) and high-Rutin group(group F).Groups A and B were given distilled water,group C were given Indometacin,groups D,E and F were given different doses of Rutin.Rutin,indometacin or distilled water was given orally,once daily,for five consecutive days.GA models were made using sodium urate crystal and medicating for two days.The circumference of the ankle joints was measured by tie line before modeling and 2,4,8,12,24 and 48 hours after modeling.At 48 hours after modeling,the rats were anaesthetized with sodium pentobarbital and then sacrificed.Their blood was collected to isolate serum.The liver and synovial tissue of the right hind limb ankle joints were immediately removed and homogenized,the levels of lipid peroxidation malondialdehyde(MDA) and nitric oxide(NO) as well as anti-oxidant enzyme including superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GSH-PX) were observed with thiobarbituric acid(TBA).Results At 48 hours after modeling,Rutin could significantly relieve edema in rats and decline the levels of MDA and NO(P0.05 or 0.01),as well as enhancing the antioxidant enzymes activity such as SOD,GSH-PX and CAT in serum,liver and synovial tissue(P0.05 or 0.01).Conclusion Rutin has remarkable effect on improving symptoms of acute GA induced by MSU crystals in rats,which might be related to its antioxidative effect.


The radiation of temporally short, wide-bandwidth pulses is required in communication and radar applications. Ideally, the antennas used in these applications should be frequency-independent to avoid signal distortion. Examples of practical, frequency independent antennas are the planar and conical spirals. These antennas are broadband for single frequency use [l, 21; however, they are dispersive when used for pulse radiation [3]-[5]. In this paper, we examine the dispersive properties of the conical spiral antenna in detail and the possibility of correcting the dispersion to make this antenna suitable for pulse radiation. xL Figure 1: Schematic diagram for the two-arm, conical spiral antenna. The twearm conical spiral antenna is shown schematically in Fig. 1. The antenna is constructed by winding two metallic strips around the surface of a truncated cone. Its geometry is mainly defined by angles: the half angle of the cone, e, , the wrap angle, a, and the angular width of the antenna arms, 6. For this antenna to be practical, it must he of finite size, i.e., it is terminated at the small end (di-arnetcr d) and at the large end (diameter D). The radiation from this antenna is often cxplaincd using the active-region concept [l]. The active region is that part of thc iintcnna thiit contributes the most to the radiation at one frequency. As illiistriitcd sc:hcmatically in Fig. 1, this region moves on the antenna (to increasing


Objective
To analyze the efficacy of retinal photocoagulation for the treatment of proliferative vitreoretiopathy(PVR) of silicone oil tamponade eyes.

Methods
The data of 64 eyes of 62 case with PVR of silicone oil tamponade from Jun. 2016 to Aug. 2017 were collected and analyzed retrospectively. According to the degree of proliferation, cases were divided into PVR-B group and PVR-C1 group, meanwhile according to times of previous surgery, cases were divided into once previous surgery group and multiple previous surgeries group.After surgery the visual acuity, intraocular pressure were observed and the efficacy of surgery were analyzed.

Results
The visual acuity after surgery improved in 28 eyes (43.75%), no obviously changed in 30 eyes (46.87%), decreased in 6 eyes (9.37%). Postoperative intraocular pressure was controlled at normal range in 55 eyes (85.93%), the highest postoperative intraocular pressure was 42 mmHg (1 mmHg=0.133 kPa), and the IOP were controlled after drugs treatment. Ⅰ degree of operative efficacy occurred in 23 eyes(35.94%), with no obvious tension proliferative membranes, thinner thickness and narrow scale of membrane; Ⅱ degree of operative efficacy in 30 eyes(46.87%), showed proliferative membranes tension decreased slightly, thickness and scale of proliferative membranes , Ⅲ degree of operative efficacy in 11 eyes(17.19%), proliferative membranes with tension, but thickness and scale of proliferative decreased. The efficacy in PVR-B group was better than that of PVR-C1 group after operation, the difference of the efficacy was statistically significant (χ2=4.180, P=0.041). The difference was not statistically significant between previous 1 time surgery group and multiple previous surgeries group(χ2=1.230, P=0.268).

Conclusion
Retinal photocoagulation for the treatment of PVR of silicone oil tamponad eyes is effective. The operative efficacy of PVR-B group is better than that of the PVR-C1 group.

Key words:
Silicone oil; Vitreoretinopathy, proliferative; Photocoagulation, retina; Efficacy


Organization recently devoted a special issue to Niklas Luhmann's systems theory. Since Luhmann's work remains relatively unknown in the English-speaking world, the issue was an important opportunity to introduce Niklas Luhmann's contribution to organization theory to this audience. Unfortunately, the primarily theoretical approach to systems theory presented in the issue may leave the reader wondering what, if anything, Luhmann's work might contribute to empirical research into organizations. This note is an attempt to draw attention to the potential of Luhmann's approach in this regard.


Case Report Radicular cysts are slow growing and are the most common odontogenic cystic lesions of inflammatory origin affecting the jaws. Most radicular cysts are small, but they can reach a large size. Sometimes, the cyst may cause displacement of surrounding structures. The purpose of this article is to report the case of a large radicular cyst that had displaced the floor of the maxillary sinus and treated by enucleation along with apicectomy and antrostomy.


The purpose of this paper is to report findings related to curriculum implementation of two types of mathematics textbooks that have different organizations of mathematical content and to discuss implications of these findings. Research has established that students learn what they are given the opportunity to learn (for mathematics, see Floden, 2002; Hiebert, 1999; Hiebert & Grouws, 2007). Ultimately teachers are the decision-makers with regard to specific content taught, but they rely heavily on curricular materials, especially textbooks, to inform such decisions. Thus it is important to determine how teachers use textbooks in the classroom. Findings reported in this paper are based on data collected as part of an NSF-funded research project: Comparing Options in Secondary School Mathematics: Investigating Curriculum (COSMIC). The COSMIC project involves a three-year longitudinal comparative study of integrated mathematics curricula and subject-specific mathematics curricula on student learning at the high school level. One group of students (n ≈ 1300) studied from an integrated content approach (e.g., Core-Plus Mathematics) and the other students (n ≈ 1300) from a subject-specific content approach (students followed an Algebra I, Geometry, Algebra II sequence). Curriculum implementation was characterized using multiple measures including classroom observations and teacher surveys which are the measures discussed in this paper. See the project website (cosmic.missouri.edu) for additional study details.


To provide necessary information for future environmental monitoring of storage batteries in Korea, authors analyzed environmental monitoring dataset of air lead concentration of 12 storage battery industries measured during 1989-2006. We calculated geometric mean and standard deviation with minimum and maximum value of each year dataset. Air lead concentration data were analyzed according to year of measurement, type of grid manufacturing method (grid casting type or expander type), size of industries and type of operation (casting, lead powder & pasting, assembly and others). The geometric mean and standard deviation of all lead industries for overall 18 years were 72㎍/㎥and 3.65 with minimum of 6㎍/㎥and maximum of 7,956㎍/㎥. The geometric mean air lead concentrations of years between 1989-1999 were above the Korean PEL(50㎍/㎥), whereas those of years after year 2000 were below the Korean PEL showing 50% of it. The geometric mean concentration of air lead was significantly lower in expander method battery industries than that of grid method battery industries and was lower in large sized battery industries than small & medium sized ones throughout the whole 18 years period. The distributions of over PEL(50㎍/㎥) were decreased by the years of environmental monitoring and those were lower in expander method battery industries than grid method battery industries. The significant reduction of mean air lead concentration during last 10 years may be induced partly due to more active environmental engineering control and new introduction of new operation in grid method battery industries, but may be also influenced by non-engineering method such as reduction of operation hours or reduction of exposure time during actual environmental measurement by industrial hygienist which is not concrete evidence, but just circumstantial evidence.


In the 1860s a new generation of architects appeared in Hungary, or more precisely, in Pest. Unlike earlier, they were no longer trained as master builders but studied at technical universities abr...


The changing personality, presence and voice of Indian women in the last decade or so leaps to the eye each time one turns on a TV set or opens a newspaper. It is unnecessary to name the thousands of Indian women who have earned a place for themselves in every sphere of our public life from space exploration to performing arts, academia, politics, industry, banking and sports. However, these myriad achievements of women have to be placed alongside the millions of women who have not had access to education. An


One of the challenges facing the world today is the control and efficient use of water resources, which both of cases require accurate study and construction associated with it. But due to the high costs that are imposed during the study stages, design and especially execution to the government, the development trend of this important and fundamental infrastructure has been made difficult. So the initial study and finding the economic and most technical method is very important degree, so that today we live in a world that physical and non-physical models are intended as the ultimate decision maker and all the profits and losses of a thought, idea, and structure are put facing us. Morning glory spillway is one of water conveyance structures from the reservoir to downstream and is named due to its horny shape. Among the strength of morning glory spillway, is the ability to build in narrow valleys and embankment dams which usually has a spillway apart from the body. In general, morning glory spillway acts in free mode, with radial and axial velocity, so that in this mode the water flow is entered directly into the spillway, but during vortex phenomenon incidence and tangential velocity causes the flow path diversion of the direct mode and travel the longer path flow and so it makes of energy loss and the discharge capacity reduce. Therefore, one of the solutions to prevent this phenomenon is anti-vortex devices installation. In this study, from the obtained results of software outputs analysis and experimental data can be pointed out to the accuracy and validity of the model compared to its similar experimental model.


Abstract. A serum panel obtained from male homosexuals (n = 278); i.v. drug abusers (n = 99), patients attending a VD clinic (n = 390), blood donors who visited Central or West Africa (n = 573), blood donors who had sexual contact with natives from Central or West Africa (n = 38), blood donors from Surinam, South America (n = 481), individuals positive for anti‐HIV‐1 (n = 94), individuals with indeterminate HIV‐1 western blot (WB) reactions (n = 73), African patients with AIDS or AIDS‐related symptoms (n = 30), and random Dutch blood donors (n = 555), was tested with HIV‐2 ELISA (ELAVIA‐2). Of these 2,611 samples, 32 (1.2%) were repeatedly reactive. Antibodies to gp140/105env were found in 4/32 by HIV‐2 WB, and in 1/4 by radioimmunoprecipitation (RIPA). These 4 HIV‐2 WB‐positive samples were also reactive with gp160/120env in HIV‐1 WB, suggesting cross‐reactivity. In a spot test with synthetic peptides of the transmembrane glycoprotein of both HIV types, 3/4 were only HIV‐1 positive and 1/4 was strongly HIV‐2 positive and weakly HIV‐1 positive. In inhibition assays with soluble HIV‐1 or HIV‐2 synthetic peptides in HIV‐1 and HIV‐2 peptide ELISA, cross‐reactivity was excluded, which indicates an HIV variant or HIV‐1/HIV‐2 double infection. It is concluded that for the moment HIV‐2 infection is at low prevalence in risk groups in The Netherlands, and that in addition to WB and RIPA, synthetic peptide assays are useful for differentiation between HIV‐1 and HIV‐2 antibodies.


"Tygodnik Ilustrowany" was one of the most important magazines in Warsaw in the 2nd half of nineteenth century. From the first issues of the magazine there is information about the national Antiquities. The reports of foreign Antiquities began to appear in the 2nd half of 1860s, and since then their number is steadily increasing. Most texts describing the discovery and ancient monuments were in the 1880s. Individual articles have appeared in the 1890s. At the beginning of the twentieth century once again increased the number of texts about Antiquities. Archaeological issues are not just confined to the news about the excavations. In "Tygodnik" placed biographies of scholars and collectors. Informed about exhibitions and museums that collect artifacts from the ancient times. Has also been reported same artifacts. There were also reprints articles in foreign languages. They were in the section "Artykuly treści naukowej, z innych piśmiennictw czerpane". Small foreign reports of findings were published in "Ze świata obcego" edited by Mścislawa Edgara Trepke (Toporczyka), and later in the "Kronika Powszechna". At this time the authors of the articles represented a variety of disciplines.


cc 2017 The Korean Academy of Prosthodontics This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Corresponding Author: Jung-Suk Han Department of Prosthodontics and Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehakno, Jongno-gu, Seoul 03080, Republic of Korea +82 (0)2072 2661: e-mail, firstname.lastname@example.com Article history: Received June 7, 2017 / Last Revision August 16, 2017 / Accepted August 21, 2017 서론


In many real‐world situations, listeners may be trying to attend to one individual while other voices are speaking in the background. These separate streams of sound hit the ear simultaneously. Within a single stream, research has investigated the extent to which lexical activation is limited by word boundary information. For example, Gow and Gordon (1995) found that multiple‐word sequences such as "two lips" may activate words such as "tulips" despite the presence of acoustic cues to a word boundary in the middle of the sequence. Yet, no studies have examined whether lexical access could "cross" signals entirely. In a series of four experiments, we test whether lexical access might (ever) cross talker boundaries. We find that when listeners hear two words spoken by two different voices (for example, a male saying "two" followed by a female saying "lips") they still activate the larger cross‐voice word "tulips," despite the presence of strong cues to an acoustic boundary. [Work supported by NSF.]


Presentation of Case First admission. A 67-year-old woman was admitted to the hospital because of dyspnea. She had been well until six years previously, when a cardiac murmur was first found on a r...


Incarcerated women experience staff-perpetrated sexual victimization at high rates, yet limited research exists regarding women's experiences of this victimization while on probation and parole, particularly regarding their formal reporting decisions. This qualitative study explored the formal reporting decisions for 10 women who experienced staff-perpetrated sexual victimization while on parole. Women who formally reported their victimization experiences qualitatively differed from non-reporting women in terms of the dynamics and their identification of victimization (e.g., viewing as support vs. fear) and in the types of structural barriers (e.g., vulnerability and cautionary tales) they encountered. These findings highlight policy, practice, theory, and research directions.


Several manufactured nanoparticles (NPs) are increasingly used in consumer goods. However, NPs may also have ecotoxicological effects after being discharged into the environment. Study of biological effects of NPs with organisms representing different trophic levels helps to understand mechanisms of uptake and following biological effects of NPs. In this study, the uptake of nano-ZnO by Tetrahymena thermophila was observed with transmission electron microscopy (TEM) and electron spin resonance (ESR). The viability of Tetrahymena thermophila and its dose-effect relationship at various concentrations of the NPs were measured. The result revealed that the model organism exposed to dispersed NPs solution have oxidative damages though lethal test did not give relationship data between survival and nanosuspension concentration in the laboratory condition. Among the NPs analyzed, nano-ZnO exhibited a dose-dependent growth stimulation to the Tetrahymena thermophila cells and others showed non-significant impact. The rapid proliferation of Tetrahymena thermophila cells was further confirmed by levels of the succinate dehydrogenase (SDH), protein content of control and treated groups.


There is provided a scanning probe microscopy comprising a probe 6 situated to face the surface of an sample 1, a first piezoelectric element 8 for moving the sample 1 and the probe 6 relative to each other in a first direction perpendicular to the surface of the sample, and second and third piezoelectric elements 3 and 4 for moving the probe and the sample relative to each other in second and third directions perpendicular to the first direction, thereby enabling the probe to scan the surface of the sample, wherein at least one of the first to third piezoelectric elements 8, 3 and 4, which is closest to the sample 1, is formed of a single crystal.


Salmonella typhimurium exhibit the ability to specifically chemotax and proliferate in heterogeneous tumor tissue in vitro. Based on this observation, we present a computer simulation to describe how S. typhimurium strains respond to chemotaxis signals that are secreted by different type of tumor cells. To test the effect of each chemoattractant on the chemotaxis of S. typhimurium toward different tumor regions, a range of simulations have been carried out by quantifying the accumulation of chemotaxis machinery knockouts, including generalized strains lacking individual cell surface chemoreceptors. To measure the bacterial accumulation affected by tumor size and structures, we compared the average bacterial density in small tumors (diameter < 500 ηm without quiescent region) with large tumors (diameter > 500 ηm contains quiescent and necrotic regions). Our work demonstrates the value of combining computer simulation with experiments to uncover potential mechanisms that are involved in bacterial chemotaxis tumor targeting and accumulation. In addition, it also demonstrates the utility of the Glazier-Graner-Hogeweg methodology (GGH) for modeling the links between cellular dynamics and environment signaling as well as predicting unanticipated results.


This manuscript is primarily dedicated on the innovative study of applying filters on 3D images. Unlike previous studies adroit efforts have been applied in understanding the effects of cascading two or more filters on noise affected colored[12] images. The experiments are performed on Matlab. In today's digital world where one clicks and expresses their emotions across various social media platforms this study plays a crucial role in improving the picture quality. The findings emphasise upon using multiple filters on various noise affected images to get the best possible image. Each filter has its own unique effect on a noisy image and in turn plays a crucial role in removing noise from the image under consideration. A single filter if applied to a noisy filter reduces the noise content in an image to an extent but if the same image is filtered iteratively from two or more filters the end result is brilliant.


The amicable settlement of inter-State disputes under the European Convention on Human Rights ('ECHR') was thoroughly discussed on Völkerrechtsblog earlier this year, during the 'Inter-State Cases under the ECHR' symposium. In this context, Keller and Piskóty perfectly depicted the numerous advantages of Friendly Settlements ('FS') under the ECHR, while Wenzel pointed to some of their problematic facets. Against this background, this post will follow a different course. Itwill seek to highlight the differentiated approach adopted by the ECHR-institutions towards inter-State FS to subsequently indicate the systemic risks that this differentiation facilitates.


Aim. The presented study aims to develop a concept of digital transformation through the example of an industrial enterprise to enable comprehensive and efficient digital transformation of separate processes, their stages, and even entire organizations in the industrial sphere.Tasks. The authors determine a series of preparatory and transformational steps that can be executed with little dependence on the competencies of the head of digital transformation and would facilitate digital transformation in the organization; develop a methodology in the form of an integrated methodological framework that makes it possible to formalize the owner of the organization as the principal and the head of digital transformation as the agent in the process of its implementation.Methods. The methodological basis of the study includes research in the field of digital transformation and the authors' analysis of digital transformation cases.Results. The concept of digital transformation developed in the study contains the necessary methodological tools for the formation of a digital transformation program and its implementation at an industrial enterprise. The created methodological basis of digital transformation makes it possible to consistently plan and carry it out, regardless of the level of digital maturity of the transformed process and organization or the level of competence of the head of digital transformation.Conclusions. The concept of digital transformation developed by the authors makes it possible to transfer digital transformation events or a large-scale program from the category of managerial search for solutions with a high level of uncertainty to the category of a methodologically sound reproducible and feasible set of actions with a high level of effectiveness. In other words, the proposed concept of digital transformation makes it not an "art" with unpredictable results depending on the competencies of the organizer, but rather a reproducible activity with predictable achievements.


The hard magnetic properties of nitrided melt-spun R(Fe,M)12 (R=Pr and Nd, M=V and Mo) ribbons have been investigated. Hard magnetic powders were prepared by vacuum annealing of ground ribbons in the temperature range from 700 to 950 °C and subsequent nitrogenation. For NdFe10.5Mo1.5Nx and PrFe10.5Mo1.5Nx powders, coercivities as high as 10.4 and 4.5 kOe at room temperature, respectively, were achieved by carefully controlling the nitrogenation process. The coercivity strongly depends on the preparation route, i.e., annealing temperature as well as nitrogenation temperature and time. By the detailed investigation of the influence of these conditions, the optimum process parameters were determined. The coercivity mechanism of melt-spun NdFe10.5Mo1.5Nx powders shows characteristics of a randomly oriented single domain particle system. Poor coercivities have been obtained for Nd(Fe,V)12 and Pr(Fe,V)12. In these cases as well as for not optimally nitrogenated Nd(Fe,Mo)12, the low coercivity of the nitrided po...


The invention provides a dynamic balance measurement method. The dynamic balance measurement method includes the steps of rotating a workpiece to be measured to rotate around a rotation axis thereof; measuring vibration displacement of the workpiece to be measured along the direction of the rotation axis so as to obtain vibration displacement data, and measuring phase of the workpiece to be measured to obtain phase data; synchronizing the vibration displacement data and the phase data to obtain phase data corresponding to maximum vibration displacement data; calculating the vibration displacement data, the phase data and the phase data corresponding to the maximum vibration displacement data so as to obtain unbalanced weight data and unbalanced position data. The invention further provides a device for the dynamic balance measurement method, and a CT (computed tomography) apparatus with the device. Dynamic balance measurement and debugging can be achieved at low cost with simplicity in actuation by the method and the device.


The theories of superalgebras and of P.I. algebras lead to a natural Z2-graded extension of the integers. For these generalized integers, a "six generalized squares" theorem is proved, which can be considered as a Z2-graded analogue of the classical "four squares" theorem for the natural numbers. This theorem was conjectured by A. Berele and A. Regev ("Exponential Growth of Some P.I. Algebras," [BR2]) and has applications to p.i. algebras.


This contribution aims to present the results of a French case-study analysis - BioBourgogne
Viande - carried up by members of three research teams in the framework of the European
Program OMIaRD (Organic Marketing Initiatives and Rural Development)1. This overall project
examine all aspects of organic products marketing in Europe in order to develop strategies that
both satisfy environmentally and ethically conscious consumers, support the development of new
jobs and improve incomes in rural communities. The project focuses on the impact of what we
name Organic Marketing Initiative (O.M.I) on rural development, especially in Less Favoured
Areas (L.F.A). An OMI is an organisation of actors (privately or co-operatively owned) involving
participation of organic producers which aims to improve the strategic marketing position of the
products by adding value to the raw product through processing or marketing. In order to
improve knowledge of success factors (in social and economic terms) of O.M.I, 67 narrative
case-study analysis were firstly carried up in 40 European regions, with a special attention in selection process (examination of highly diverse OMIs, in different geographical, cultural, agroecological
and political contexts). Then, researchers implemented a comparative in-depth case
study analysis involving 4 selected O.M.I located in Austria, France, Italy and the United
Kingdom and based on interviews of internal, external and interface stakeholders.
In a first part, after a brief description of the region where the O.M.I is located, we present the
main features of the development of BioBourgogne Viande, from its origins to the present day. In
a second part, the motivations, cohesion and competencies are analysed in the structure of a
SWOT (opportunities, threats, strengths and weaknesses), identifying organisational learning
processes through the past ten years.


Congenital heart defects are the most common chronic congenital anomalies in childhood. They occur as a consequence of the action of genetic and multifactorial factors. Feasibility is present in both sexes, regardless of the economic situation of the country. They lead to structural and functional changes in the heart muscle, thus interfering with its normal functioning. The most effective method of treating and solving the problem of heart defects is surgery. By being exposed to an invasive procedure, they encounter numerous postoperative risks, and it is necessary to provide maximum care and support. The formation of a care team, the application of the health care process, ensures adequate conditions during the stay in the tertiary level health institution. This paper presents all the necessary segments of nursing care, in children with a diagnosis of congenital heart defect. The segments arise from the process of health care. Professional action is based on independent and interdependent nursing interventions. Key words: congenital heart defect, cardiac intensive care, nursing diagnoses of heart defects in children, postoperative care of heart defects.


This article focuses on the mother-child relationship and its complexity, as presented in some novels of the Nobel Prize winner, J.M.G. Le Clezio. The somatic transformation of women while giving birth to their children underlines the emergence of an identity crisis, leading to the difficulty to connect or rely on other people. Trying to remain a feminine while embracing maternity, the woman finds herself alone or abandoned in a world where suffering and despair return repeatedly.


Objective To investigate the expression of telomerase,estrogen receptor( ER) and c-myc protein in synchronous primary endometriod adenocarcinomas of the uterus and ovarian. Methods A total of 16 synchronous primary endometrial and ovarian carcinomas surgical specimens were collected. All patients' clinical-pathological stage wasⅠstage, immunohistochemical PV-6000 two-step was used to detect the immunophenotype of telomerase( hTERT),ER and c-myc expression in uterine and ovarian carcinomas at one patient. Results Eleven cases( 68. 75%) had the same immunophenotype of telomerase in the tissues of uterine and ovarian carcinomas,and 5 patients( 31. 25%) had different telomerase expression; ten cases( 62. 5%) had the same immunophenotype of ER common to uterine and ovarian carcinomas,and 6 cases( 37. 5%) had different ER expression; ten cases( 62. 5%) had the same immunophenotype of c-myc,and 6 cases( 37.5%) had different c-myc expression. There were no statistically significant differences in the expression of telomerase,ER and c-myc protein in synchronous primary endometriod adenocarcinomas of the uterus and ovarian( all P 0. 05). There were 7 cases( 43. 75%) of positive expression of ER,c-myc and telomere in both uterine and ovarian endometriod adenocarcinomas. Conclusion The expression of telomerase,ER and c-myc may be similar in the synchronous primary carcinomas of uterine and ovarian,and there may be homology between two sites cancers.


When calculating frequency-domain near fields by the FDTD method, almost 50 % reduction in memory and CPU operations can be achieved if only E-fields are stored during the main time-stepping loop and H-fields computed later. An improved method of obtaining the H-fields from Faraday's Law is presented and shown to be orders of magnitude more accurate than the straightforward approach, at no additional cost. The method is validated by comparison with analytical solution of a traveling wave, and on simulations of dipole and patch antennas.


This paper means to sum up the history of the autobiographical genre throughout History, from its first literary expressions to present ones. This genre, sometimes condemned to obscurity, contains some very important works both in Spain and abroad.


The present invention relates to an apparatus for saturating syngas with steam, which comprises: a syngas supply unit which supplies syngas at the time of steam saturation for a water-gas shift reaction; a steam supply unit which supplies steam; and a reaction unit in which the syngas supplied by the syngas supply unit is saturated with the steam supplied by the steam supply unit, wherein the reaction unit has a static mixer in the inside thereof for mixing the syngas with the steam and extending a retention time for the reaction between the syngas and the steam so as to saturate the syngas with the steam. According to one embodiment of the present invention as described above, the apparatus has the static mixer and thus can effectively saturate syngas with water, and maintains an appropriate temperature of the water and the syngas for a water-gas shift reaction without using a separate cooling device.


Objective: To separate and culture eosino_lactobacillus living in vagina.Methods: lactobcillus was cultured and storaged by selecting different culture medium and antifreezer.Results: Different effects on lactobacillus growth in different nitrogen, carbon and bacteriostatic medium and on lactobacillus activity in differents antifreezer were observed.Conclusion: lactobacillus could be produced in large quantities by selecting culture medium and be storaged well by selecting antifreezers.


The advantages of having Designers and Constructors work together at an early stage is explained and examples given of positive results which have been achieved when these two groups have formed an early partnership. The argument is put forward that if input from Constructors is available to the Design Team at an early stage not only are wastes minimised and designs improved, but the Constructors have a vested interest in efficiently bringing the designs, to which they have contributed, to successful reality. Examples of how basic ideas have been refined and improved by co-ordination and co-operation, how costs of constructions have been lowered and building periods shortened and how early involvement of Constructors has given them positive attitudes toward innovative solutions are described in some detail and illustrated. The proposal is made that for physical resources to be optimally developed, then human resources - which are the most valuable of all resources - must be utilized in the best way possible and this can only be done in an atmosphere of co-operation. The conclusion reached is that the results of early co-operation are overridingly worthwhile.


How can the limitations of an atrophic mandibular denture-bearing area be overcome when making a definitive impression for a mandibular complete denture? The creation of a complete mandibular denture for a patient with an atrophic denture-bearing area presents significant challenges to the clinician (Fig. 1). A " suitable " denture-bearing area has both appropriate height and sufficient width, both of which limit the ability of displacing forces to dislodge the complete prosthesis that rests on it. However, in atrophic mandibles, where there has been extensive bone loss, there is little structure available to provide resistance to the displacing forces that arise from occlusal contacts during mastication or functional muscular activity. This problem is complicated by the fact that patients presenting with an atrophic mandibular ridge are typically elderly, have been edentulous for a considerable period of time, have a complicated medical history and may have limited financial means. Although an implant-retained mandibular overdenture might be considered for such patients, this type of prosthesis is usually contraindi-cated because of insufficient bone or for financial or other medical reasons. A functional impression technique is often suitable for making an impression of an atrophic denture-bearing area. This type of impression is made by applying a suitable material, such as a tissue-conditioning agent, to the fitting surface of the existing prosthesis. The patient is instructed to wear this material for up to 48 hours, during which time an impression of the atrophic area is made under functional stresses. Technique Examine the patient's existing mandibular complete denture, specifically at the buccal and lingual extensions. If these are overextended, reduce these areas first. Clean the mandibular denture with ethanol. Apply the tissue-conditioning material (Ardee tissue liner, Reliance Dental Manufacturing Co., Worth, Ill.) to the fitting of the mandibular denture as 2 rectangular strips, 1 for each half of the fitting surface. Trim and seal the overlap at the midline with a hot wax knife. Adapt the material to the periphery of the denture, and seal the edges to the labial or buccal and lingual surfaces using the hot wax knife (Fig. 2). Insert the denture in the mouth, and ensure that the maxillo-mandibular relationship or the vertical dimension of occlusion has not been significantly altered. Discharge Figure 1: Atrophic mandibular denture-bearing area. Figure 2: A strip of Ardee tissue liner applied to the left half of the intaglio of the mandibular complete denture. The Point of …


Commiphora mukul (CM) is reported for several neurological disorders, but it is not been reported for its antidepressant activity. The aim of the present work was to evaluate the antidepressant activity of a hydroalcoholic extract of Commiphora Mukul (HECM) and its chloroform and ethyl acetate fractions using acute depression models in mice. The effects of acute oral pretreatment of HECM (50, 100, or 200 mg/kg p.o.), chloroform soluble fraction and ethyl acetate soluble fraction of HECM (20mg/kg p.o. and 40 mg/kg p.o.) and fluoxetine (10 mg/kg p.o.) were evaluated using force swim test (FST) and tail suspension test (TST) in mice. Immobility duration in FST and TST was measured one hour after of all the treatments. At the end of TST plasma corticosterone was measured. Both HECM and both the fractions showed dose dependent normalization of immobility duration in both the parameters along with the normalization of plasma corticosterone levels. HECM exerts antidepressant effect in acute models of depression in mice.


Background: In ROMA II trials we ascertained that the reloading of statin, in stable patients on chronic statin therapy, decreases the incidence of periprocedural myocardial infarction (PMI) comparing with the standard treatment. Objectives: We sought to investigate the impact of gender difference on the efficacy of statin reloading to reduce the PMI. Methods: In ROMA II trial, patients who underwent elective PCI, were randomized to receive a pre-procedural loading dose of statin or the standard treatment. In this sub-analysis patients were divided in two groups according to gender differences. Results: Twelve and 24-hours post-PCI Troponin T (TnT) elevation > 5 x 99th percentile URL frequency didn't show significant differences between men and female treated with a reloading dose of statin (respectively, at 12-h: 11.3% vs 8.3%; p = 0.22 and at 24-h: 16.7% vs 17.9%; p = 0.97). At 12-months follow-up the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) did not show significant differences between men and female treated with reloading dose of statin (respectively, 5% vs 4%, p = 0.62, Log-rank test). Conclusions: PMI is not correlated with sex in stable patients reloaded with statin.


In the years since Wislawa Szymborska was awarded the Nobel Prize in Literature much as been made of the "wit, wisdom, and warmth" of her poetry, and rightly so. 1 But little critical attention has been directed toward the questions about mourning which she articulates in her later work. In Koniec i poczqtek [The End and the Beginning] (1993), Szymborska alights upon some of the same funerary terrains which Freud surveyed in his 1917 paper "Mourning and Melancholia." Yet, whereas the mourner of Freud's study covers over the gap that separates a griever's insufferable pain and passes to the safe ground upon which mourning could be resolved, Szymborska allows the voices of these poems to fall deeply into this chasm, this cauldron of mourning. An interminable work of mourning, Szymborska's volume of poetry departs from Freud's conclusion. Since Jacques Lacan, on the other hand, speaks of the failure immanent to mourning work in his Seminar VI, Le Desir et son interpretation [Desire and Its Interpretation] (1958-1959), his interpretive lens is more useful to a reading of Szymborska's subtle elaborations on the subject of loss. In Koniec i poczqtek Szymborska does not attempt to transcend grief via some successfully accomplished symbolization of mourning; instead, she respectfully encircles the voids revealed by intractable loss. To this end, she exploits the formal constraints of her practice to insist upon the impossibility of finishing a requiem. Szymborska does not invest her works with the content of things mournful, but rather develops a poetics which keeps the work of mourning in process, unfinished.


1. Research Background The journalist brings extensive investigative research to bear on key issues of nuclear policy and diplomacy with significant implications for Australia, e.g. the crisis of the NPT (Nuclear Non-Proliferation Treaty), Iran and North Korea's nuclear programs, and debates about whether Australia should develop a uranium enrichment capability. Both documentaries ask the research question: has the framework of nuclear safeguards and controls embodied in the NPT become obsolete as a result of changing geo-political and strategic factors? What does this mean for Australia's nuclear policy? 2. Research Contribution Drawing on a wide range of original interviews with diplomats, former and serving officials and nuclear policy experts, as well as extensive research these documentaries develop a critique of the 'global nuclear renaissance' and the political, diplomatic and economic interests behind the push for an expansion of nuclear power and uranium enrichment.


50 Gb/s passive optical network (50G-PON) is the latest highspeed access network standard approved by the International Telecommunication Union-Telecommunication Standardization Sector (ITU-T). 50G-PON is developed to meet the ever-growing bandwidth requirements from broadband access users, especially for new applications in the areas other than traditional residential and business access. This paper focuses on new applications of using 50G-PON in industrial networks. These applications employ the highspeed capability of 50G-PON to facilitate industrial manufacturing, product quality assessment, as well as smart factory management. After introducing the main features of 50G-PON and the recent progress in industrial networks, an architecture is proposed to employ 50G-PON for industrial networks. Key requirements of industrial networks are analyzed, including bandwidth, delay, and jitter. Use cases are discussed to illustrate typical applications and scenarios. A testbed with a 50G-PON prototype system is setup to evaluate the industrial network application. Test results show salient performance of using 50G-PON for industrial network management and automation.


The Institute of Museum and Library Services
(IMLS) is an independent grant making agency and the primary source of federal support for the nation's approximately 120,000 libraries and 35,000 museums and related organizations. IMLS helps ensure that all Americans have access to museum, library, and information services. The agency supports innovation, lifelong learning, and cultural and civic engagement, enabling museums and libraries from geographically and economically diverse areas to deliver essential services that make it possible for individuals and communities to thrive. The agency's mission is to inspire libraries and museums to advance innovation, learning, and civic engagement and to provide leadership through research, policy development, and grant making.Those goals are reflected in this year's report as IMLS continues to be an outstanding steward of federal funds. IMLS will continue to look for ways to achieve even greater impact on library and museum services throughout the United States.


On October 5–6, 2015, the third international user workshop focusing on high-power lasers at the Linac Coherent Light Source (LCLS) was held in Menlo Park, CA, USA [1, 2]. The workshop was co-organized by Los Alamos National Laboratory and SLAC National Accelerator Laboratory. More than 110 scientists attended from North America, Europe, and Asia to discuss high-energy-density (HED) science that is enabled by the unique combination of high-power lasers with the LCLS X-rays at the LCLS-Matter in Extreme Conditions (MEC) endstation.


About a century after von Nordmann (1832) first found strigeid metacercariae occurring in the eyes of fishes, La Rue, Butler, and Berkhout (1926) demonstrated that they were common habitats for species of these larval trematodes. Strigeid metacercariae have also been reported from the eyes of certain amphibians (Kelley, 1934). Various parts of the eye may be parasitized, depending upon the species of worm. This paper deals with metacercariae of the genus Diplostomulum that live only in the cortex of the lens, and is a report of experiments in which it has been found that worms ordinarily developing in the eyes of fishes, and in many cases causing complete blindness, will grow in the lenses of both coldand warm-blooded animals representing four other classes of vertebrates. The experiments were performed as an outgrowth of studies on the life history and control of eye flukes in the New Jersey State Fish Hatchery at Hackettstown. The trematodes represented at the Hatchery appear to resemble both Diplostomum flexicaudum and D. indistincturn (Ferguson and Hayford, 1941), and studies now in progress may show that these recognized forms are variants of a single species. All cercariae used in exposure experiments resembled closely, as far as morphology and behavior were concerned, the cercariae of D. flexicaudum (Cort and Brooks, 1928).


The invention relates to an IQ signal calibration method and apparatus, being used for calibrating an IQ signal of a transmitter in a wireless communication system. The method comprises the steps of acquiring a first signal and a second signal, wherein the first signal is an I path of test signal that is transmitted by the transmitter and sampled by a receiver analog-digital converter (ADC), and the second signal is a Q path of test signal that is transmitted by the transmitter and sampled by the receiver ADC; respectively performing mutual correlation operation on the first signal and the second signal so as to acquire a first parameter corresponding to the first signal and a second parameter corresponding to the second signal; acquiring a calibration parameter according to the first parameter and the second parameter; and calibrating the IQ signal of the transmitter according to the calibration parameter. Through adoption of the method, the problem of frequency domain selective IQ imbalance generated in synthesis of I path of signal and Q path of signal can be overcome effectively, and the method is simple and can effectively improve IQ signal calibration accuracy.


The problem of quantitative interpretation of highresolution electron micrographs is studied in the framework of parameter estimation. Ideally, quantitative interpretation means that unknown structural parameters of an object such as atom types and coordinates are determined from fitting with the experimental dataset. However, in the imaging process, the influence of these parameters is completely scrambled over a large area of the image. As a consequence, the fitting becomes a search process in the higher dimensional space of all coupled parameters. The real importance of the so-called direct methods such as holographic exit wave reconstruction and direct structure retrieval is that they restore (deblur) to some extent the imaging process so as to unscramble the influence of the different model parameters. In this way the dimension of the search space becomes manageable. In this framework the concept of resolution in the sense of Rayleigh is not valid anymore, but it has to be replaced by the notice of parameter precision. In case two atoms are very close, the parameter space may become degenerate so that the atoms cannot be discriminated. The probability of this degeneracy to occur is a function of the distance between the atoms and the dose of the imaging particles.


Table Of Contents Introduction Jessica Spector "Introduction: Sex, Money, and Philosophy" I. Critiques of the Sex Industry Ch.1 Vednita Carter and Evelina Giobbe "Duet: Prostitution, Racism, and Feminist Discourse" Ch. 2 Christine Stark "Stripping as a System of Prostitution" Ch.3 Carol Pateman "What's Wrong with Prostitution?" Ch.4 Catharine MacKinnon "Equality and Speech" Ch.5 Margaret A.Baldwin "Split at the Root: Prostitution and Feminist Discourses of Law Reform" II. Liberalism and Prostitution Ch.6 Norma Jean Almodovar "Porn Stars, Radical Feminists, Cops and Outlaw Whores: The Battle Between Feminist Theory and Reality, Free Spirits and Free Speech" Ch.7 Martha Nussbaum "'Whether From Reason or Prejudice': Taking Money for Bodily Services" Ch.8 Sibyl Schwarzenbach "Contractarians and Feminists Debate Prostitution" Ch.9 Laurie Shrage "Prostitution and the Case for Decriminalization" III. Liberalism and Pornography Ch.10 Theresa Reed "Private Acts vs. Public Art: Where Prostitution Ends and Pornography Begins" Ch.11 Joshua Cohen "Freedom, Equality, Pornography" Ch.12 Ronald Dworkin "Women and Pornography" Ch.13 Laura Kipnis "Disgust and Desire: Hustler Magazine" IV. The Limits of Liberalism Ch.14 Tracy Quan "The Name of the Pose: A Sex Worker by Any Other Name" Ch.15 Julian Marlowe "Thinking Outside the Box: Men in the Sex Industry" Ch.16 Scott Anderson "Sexual Autonomy and Prostitution: Making Sense of the Prohibition of Prostitution" Ch.17 Debra Satz "Markets in Women's Sexual Labor" Ch.18 Jessica Spector "Obscene Division: Feminist Liberalism's Treatment of Prostitution and Pornography" Notes Bibliography Index


From the relationship between the coal and ash characteristic and the design of the power plant boiler,discusses the characteristic index of the coal and ash having effect on the safe and economic operation of the boilers,expounds the relationship between the coal quality of the boiler design and the coal quality of fhe verification.


Objective:To evaluate the application of antimicrobial drugs in inpatients of our hospital during 2007-2009,and provide references for rational use and management of antimicrobial drugs.Methods:The data of antimicrobial drugs in inpatients during 2007-2009 were analyzed retrospectively in respect of the sales amount,DDDs and DDC.Results:The proportion of consumption sum of antimicrobial drugs in the total decreased year by year.Cephalosporins,carbapenems and quinolones dominated the top three on the consumption list of all the antimicrobial drugs during three years.Cefepime for injection ranked the first place in respect of sales amount and DDDs from 2007 to 2009.Conclusion:The use of antimicrobial drugs was basically rational in our hospital;however,there were also some inappropriate problems such as selection of senior antibiotics,drug overdose,and loosely hierarchical management.


The quality of depth images is crucial for virtual view synthesis. However, the quality assessment of depth images is still largely unexplored. This letter presents a blind quality metric of Depth image based on Structural Statistics (DSS). The design philosophy is inspired by the fact that structural distortion in the depth images usually leads to geometric distortion, which is the main cause for degraded quality of synthesized views. Specifically, the statistical features for shape and orientation are calculated based on discrete orthogonal moments and gradients, generating two groups of quality-aware features. Then, the quality model is built from the extracted statistical features using a regression module. The experimental results demonstrate the effectiveness of the proposed metric.


In this review, an introduction to the concept and fundamental principles of immunosensor is given, and immunosensor is classified into many types according to the difference of transducers, each type being compared with others and explicated in derivation and developing process respectively. Two problems about the fabrication of immunosensor, which are immobilization and reproductivity, are addressed fleetly. In addition, the application and developing tendency of immunosensor are described briefly.


Postural Analysis is an important aspect of clinical assessment by physical and occupational therapists to assist in determination of the origin of weakness or functional deficit in neurologically compromised individuals. It can be difficult to perform said analysis in an upright position due to limitations in support for the individual being assessed resulting in decreased safety for both the individual and the clinician. Use of robotic devices to provide external support for the individual in a dynamic movement pattern may allow the clinician the freedom to assess the client in an upright position while maintaining client safety. Therefore, a more thorough evaluation of deficit areas of muscle weakness, tightness, substitution, and functional deficits may be completed to formulate an effective treatment plan. One example of the use of a robotic mobility device for this purpose is the REX from Rex Bionics, Inc. This robotic mobility device allows for both assessments of postural deficits and treatment in an upright position. Following postural analysis of muscular deficits during walking in REX, REXERCISES may allow the clinician to use a series of pre-programmed positions to challenge specific muscle groups identified in the postural analysis to improve muscle strength, decrease tightness, or improve specific functional mobility tasks. These REXERCISES can be performed with assistance from the therapist or with resistance using the standard tools, i.e. hand-weights, balls, resistance bands, etc, that clinicians typically use for strengthening. The above principles can most effectively be demonstrated through on-site performance of the process. Therefore, the process will be demonstrated with a specific patient based upon the deficits seen in analysis of the individual outside of the REX and applied to treatment in the REX to correct them.


Er3+-doped tellurite glasses with chemical compositions (in mol%): 55TeO2-35ZnO-(5+x)PbO-2Bi2O3-(2-x)Na2O-Er2O3 with x = 0; 0.5; 1.0; 1.5 and 2.0) were synthesized and explored their physical and optical properties. Density and refractive index were measured at room temperature and other physical properties such as ionic packing ratio, field strength, polaron radius, internuclear distance and molar refraction were derived. It was found that Na2O substitution by PbO causes both refractive index and glass density increase.


Abstract Objective To study the influence of policy changes in the evaluation of neonatal hyperbilirubinemia on discharge process from the nursery. Changes included early assessment of risk factors by universal umbilical blood sampling for blood type, Coombs test, and glucose-6-phosphate dehydrogenase (G6PD) and universal noninvasive transcutaneous bilirubinometry at discharge. Study Design The 1,569 newborns (≥ 36 weeks' gestation) admitted after the implementation of changes were compared with the 1,822 born before. Results Policy changes improved the diagnosis of G6PD deficiency and ABO incompatibility and decreased the number of referrals from the community for jaundice follow-up. The average number of needlesticks per baby as well as the time required for the analysis of serum bilirubin levels on discharge day decreased. Changes did not significantly increase costs. Conclusion Changes seem to have improved the quality of medical care, including early identification of risk factors and better follow-up of neonatal hyperbilirubinemia with reduction of pain and increased efficiency.


Silicon carbide (SiC) is ideally suitable as a sensor material in harsh environments. Despite the brittleness in the macroscopic scale, plasticity in SiC is observed at small component length-scales. Previous nanoindentation based study combining experiment and numerical approaches of single-crystal 6H-SiC has shown that slip activation is rather complex, and that non-basal slip could potentially dominate the plastic deformation behaviour. In this study, we investigated the local deformation response evolution of shear strain directly under and in the vicinity of the indenter tip. The results show the pyramidal slip families contribute significantly to the deformation process.


This paper proposes a directional transducer-enabled neighbor discovery algorithm in integrated sensing and communication for underwater acoustic networks (ISAC-UANs). The neighbor discovery algorithm is a bidirectional scanning-based (SBA) and detection-assisted neighbor discovery (SBA-D) algorithm, which is divided into three steps. Firstly, in ISACUANs, prior knowledge about the distance away from neighbor nodes is obtained via the detection ability. Secondly, the neighbor discovery of detected nodes stage is proposed leveraging the prior knowledge to adjust the transmission power, which reduces the packet collision probability of discovering the detected neighbor nodes. Thirdly, the neighbor discovery of remaining nodes stage is proposed to discover the remaining neighbor nodes following the SBA algorithm. Furthermore, we analyze and derive the performance of the proposed SBA-D algorithm. Numerical simulation results show that the performance of the proposed SBA-D algorithm for ISAC-UANs is better than that of the SBA algorithm in underwater acoustic communication networks (UACNs).


A 4.0λ-cavity GaN-based vertical-cavity surface-emitting laser (VCSEL) using an n-type conductive AlInN/GaN bottom distributed Bragg reflector (DBR) showed a light output power of 1.8 mW with a low differential resistance of 90 Ω. In order to obtain low resistive AlInN/GaN DBRs, 5 nm AlGaInN graded interfaces were introduced. A 40-pair AlInN/GaN DBR with the graded interfaces showed a peak reflectivity over 99.8% and a series resistance of 17 Ω. At the same time, the maximum light output power of a 1.5λ-cavity GaN-based VCSEL with the conductive DBR was only 0.03 mW due to a high thermal resistance of 2700 K W−1 caused by a high thermal resistivity of AlInN. We also conclude that a short cavity typically used in GaAs-based VCSELs is not appropriate in GaN-based VCSELs.


Nerve cells of different functions cannot be differentiated histolog-ically b y staining methods. In order to prove chemical differences it is necessary t o affect the function of a given type of neuron by the action of a chemical agent. Thus Baglioni 1 has demonstrated a chemical difference between sensory and motor cells in the frog and the squid, by showing that phenol is an excitant for the motor ganglia alone while strychnine stimulates the sensory ganglia only of these forms. Maxwell ~ has shown that the nerve cells of the mammalian cortex are sfimulatedby one class of substances which includes creatine and strychnine, but that such substances do not act on medullat.ed nerve fibers. Only certain salts, such as the calcium precipitants and barium compounds, act upon medullated fibers. On the other hand these salts do not stimulate the gray matter of the brain. Tetra-ethyl-ammonium chloride is an exception in that it acts upon structures of both types2 It is possible that chemical differences exist between nervous systems of various forms. 4 For example, coelenterates give no spasm response to strychnine, but echinoderms do, provided the concentration of alkaloid is sufficiently high, while cephalopods are as sensitive to strychnine as vertebrates are. On these grounds ParkeP has suggested that strychnine might be used as a test for the presence of synapses, since sensitivity to strychnine on the part of different 1Baglioni, S.


. With the continuously growing amount of data offered in the form of knowledge graphs, users are often overwhelmed by the amount of potentially relevant information and entities. Hence, helping users find relevant data is a problem that becomes more and more important. Skyline queries are typically used in multi-criteria decision making applica-tions to find a set of objects that are of interest to a user. This type of queries has been extensively studied over relational data in the database community. But only little attention has yet been paid to investigating if and how the skyline principle can help identifying sets of interesting entities in knowledge graphs. In this paper, we therefore show how the skyline principle can be applied to RDF knowledge graphs and help the user find interesting entities. In particular, we present algorithms using commonly used standard interfaces for accessing RDF data and a lightweight extension of existing interfaces (SkyTPF) to process skyline queries. Our experiments show that the proposed algorithms enable efficient and scalable skyline query processing over knowledge graphs.


H. M. Cammack,1 P. Kirton,1 T. M. Stace,2 P. R. Eastham,3 J. Keeling,1 and B. W. Lovett1 1School of Physics and Astronomy, University of Saint Andrews, Saint Andrews KY16 9SS, Scotland, United Kingdom 2Centre for Engineered Quantum Systems, School of Mathematics and Physics, The University of Queensland, Saint Lucia, Queensland 4072, Australia 3School of Physics and CRANN, Trinity College Dublin, Dublin 2, Ireland


Abstract : The tasks in the Statement of Work for this Contract were: Develop quantitative methods of secondary ion mass spectrometry (SIMS) analysis; and Study the incorporation and redistribution of impurities in (HgCd)Te and CdTe. The second task included investigation of MeV ion implantation into (HgCd)Te and development of image processing techniques for potentially quantitative investigation of laterally distributed impurities. The mechanisms and protocols developed were applied to various kinds of (HgCd)Te and it homologs in the characterization of a variety of dopants and impurities of interest to DARPA and its subcontractors. These applications elucidated the mechanism of boron incorporation during the LEC growth of CdTe.


The invention relates to a device (1) for producing a with at least one anti-corrosion layer (K) magnesium-containing coated substrate (S). According to the invention a forming tool (2) for conversion of the substrate (S) is provided and in the forming tool (2) a flame coating unit (3) and / or a plasma coating unit (5) for winding and / or insertion of at least one anti-corrosion layer (K) before a forming process, between a plurality of forming processes and / or integrated directly by a forming process. The invention further relates to a method for producing a with at least one anti-corrosion layer (K) magnesium-containing coated substrate (S). According to the invention the substrate (S) by means of a forming tool (2) is formed and on and / or in the substrate (S) is within the forming tool (2) against a forming process, between a plurality of forming processes and / or immediately after a forming process by means of a in the forming tool (2) integrated flame coating unit (3) and / or plasma coating unit (5) the at least one corrosion protection layer (K) up and / or incorporated.


The number of children with Severe Motor and Intellectual Disabilities (SMID) receiving medical treatment/recovering at home is rising yearly. Although benefits of this care are emphasized, the stress and duties of family members in the household are extremely great, especially because Japan is becoming a society of nuclear families. In this study, we described the lifestyles of nuclear families providing in-home medical care for children with SMID, focusing on family members' roles. Roles of mothers, fathers, and siblings of children with SMID were summarized from semi-structured inter-views. As a result, for "the roles of each family member living with a child with SMID", mothers had five roles, fathers seven, and siblings five. For "the hopes of each family member living with a child with SMID", parents desired the whole family collaboration in care for children with SMID, and as caregivers, parents' common thoughts included wanting siblings in order to help care for the child with SMID and wanting siblings to treasure their own lives. Siblings wanted their mother to have some time for rest and expected their fathers to have two main roles. They also expected their grandparents and other siblings to fulfill roles.


The present invention provides a method for producing a detergent particles, which comprises the step (B): an anionic surfactant paste and mixed alkyl glyceryl ether modulating step anionic surfactant composition, and a step (C): the composition of the anionic surfactant oil-absorbing ability and the step (B) obtained in the modulation of 0.2mL / g or more base particles by mixing a modulation step of the detergent particles. By using the manufacturing method of the present invention, the following effects can be obtained: no drying step of removing the water after mixing the base particles anionic surfactant compositions and oil absorption capacity of 0.2mL / g or more, it can be produced while inhibiting particle growth, narrow particle size distribution, high solubility, and thus the cleaning effect of the detergent particles is high. By inhibiting the growth of particles, narrow particle size distribution can be obtained not only improve the appearance, but also excellent solubility detergent. Further, regardless of the difference in the coarse base particles in the detergent particles can be suppressed manufacturing obtained coarse rate.


Genetics of Alzheimer's Disease: Insights for Therapy his ACADEMIC HIGHLIGHTS section of The Journal of Clinical Psychiatry presents the highlights of the planning teleconference series "Cognitive Impairment Associated With Depression in the Elderly," which was held in May and June 2007. This report was prepared by the CME Institute of Physicians Postgraduate Press, Inc., and was supported by an educational grant from Forest Pharmaceuticals, Inc. The planning teleconference series was chaired by Steven P. Roose, M.D., Department of Psychiatry, Columbia University, New York, N.Y. The faculty were Davangere Devanand, M.D., Columbia University and New York State Psychiatric Institute, New York; Roy Hamilton, M.D., M.S., Alzheimer's Disease Center and Penn Memory Center, University of Pennsylvania, Philadelphia; K. Ranga R. Krishnan, M.D., Department of Psychiatry, Duke University Medical Center; Richard Mayeux, M.D., M.Sc., Columbia University, College of Physicians and Surgeons, New York, N.Y.; and Gary W. Small, M.D., University of California, Los Angeles, Semel Institute for Neuroscience and Human Behavior, Los Angeles. In the spirit of full disclosure and in compliance with all ACCME Essential Areas and Policies, the faculty for this CME article were asked to complete a statement regarding all relevant financial relationships between themselves or their spouse/partner and any commercial interest (i.e., a proprietary entity producing health care goods or services consumed by, or used on, patients) occurring within the 12 months prior to joining this activity. The CME Institute has resolved any conflicts of interest that were identified. The disclosures are as follows: Dr. Roose has received grant/research support from Forest and Bristol-Myers Squibb and is a member of the speakers/advisory boards for Forest, Novartis, Wyeth, Sanofi-Aventis, and Cyberonics. Dr. Devanand has received grant/research support from Wyeth, Eli Lilly, and Forest and has received honoraria from the American Psychiatric Association (APA). Dr. Hamilton has received honoraria from the APA. Dr. Krishnan is a consultant for Amgen, Bristol-Myers Squibb, CeNeRx, Corcept, GlaxoSmithKline, Johnson & Johnson, Lundbeck, Merck, Organon, Pfizer, Sepracor, and Wyeth. Dr. Small is a consultant for and has received honoraria from Pfizer, Eisai, Abbott, Novartis, Ortho-McNeil, and Dakim; is a member of the speakers/advisory boards for Pfizer, Eisai, Ortho-McNeil, and Novartis; is a stock shareholder of Dakim and Brainstorming; and is among the inventors of a patent owned by UCLA that is licensed to Siemens and receives royalties from Siemens. Dr. Mayeux has no personal affiliations or financial relationships with any proprietary entity producing health care goods or services consumed by, or used on, patients to disclose relevant to this presentation. The opinions expressed herein are those of the faculty and do not necessarily reflect the views of the CME provider and publisher or the commercial supporter. In the United States and worldwide, the group of people 65 years and older is the most rapidly growing population. By the year 2030, this older population is projected to be more than twice as large as it was in 2000, growing to 72 million in the United States (974 million worldwide) and comprising almost 20% of the total U.S. population. The group of individuals 85 years and older is expected to expand especially rapidly until and after 2030 as the Baby Boomer generation ages. With the increase in this population, the late-life health issues of depression and dementia will increase, calling for improved diagnostic and treatment approaches and a more complete understanding of the relationship between these disorders. Steven P. Roose, M.D., gathered experts in the fields of dementia and depression to discuss and address these issues. Their presentations offer insight into the complex relationship between cognitive impairment and depression and provide strategies that address these conditions.


The improvement of software processes plays an important role in the developing of systems that obtain a higher quality product. Redesigning software takes a considerable amount of time. Even making a small change is a difficult task and it takes a long time to obtain better results. Moreover, if the software tools that help this change are not properly managed, the improvement in the development of the System could be stopped. This paper presents a process of changing a web system which uses an initial complex design to another one that uses a simpler and improved development tools such as the ZK and Hibernate Framework, which final result is indeed improved Software.


386 Background: Recent data has demonstrated that regular ASA use improves overall and cancer-specific survival in the subset of CRC patients harboring PIK3CA mutations. However, as this series only analyzed 15 PIK3CA mutant CRC patients with metastatic disease at diagnosis, it remains uncertain whether the survival benefit associated with regular ASA use extends to patients with metastatic disease. We combined data from two large academic institutions to explore the association between regular ASA use and survival in metastatic CRC. Methods: Patients with PIK3CA mutated CRC were identified at Moffitt Cancer Center (MCC) in Tampa, FL and Royal Melbourne Hospital (RMH) in Australia. Prospective clinicopathological data (including age, sex, site of disease) and survival data were available. At MCC, PIK3CA mutations were identified by exome sequencing using an Illumina Next Generation Sequencing platform with 50-100X coverage. At RMH, Sanger sequencing was used to identify PIK3CA mutations. Survival analyses...


Meet some of the world's leading Virtual Reality storytellers who are defining the conventions and language of this new medium. How does it work, and what works well?