The article aims to discuss the relation between sustainability and its impact on the labor market, especially on the work processes. Sustainable development is a holistic concept in which the economic, the social and the environment are in an inextricable connection. Due to these reasons on sustainability, a variety of views were issued. However all the debates have a common divisor: sustainability - technology connexion. From the technology point of view, our century should be the luckiest from humans' history: it gains from a technology that conserves natural resources and energy, with high productivity and high efficiency that is environmentally friendly and more equitable in its impact globally. Unfortunately, it still has a major vulnerability: the new technology doesn't by itself solve the sustainability issues of the Earthlings and Earth. And the way of managing the benefits associated with computer technology, leaves gaps too wide to disseminate risk and hazard, on the macro-social and individual levels. We are at the beginning of 'The Hybrid Age' in which the new socio-technical era is unfolding as technologies merge with each other and humans merge with technology. Current technology's true impact isn't just physical or economic, but social and psychological as well. The article (i) analyzes some of the technological consequence on the formal work dynamics and, (ii) proposes some subjects of reflection on the most neglected aspects of the 'sustainability". 


Autonomous robotic observatories can use modern communications to receive pertinent information from institutes that generate events to observe (e.g., supernovae, near-earth asteroids, gravitational lensings, and gamma-ray bursts).
This paper is addressed to astronomers who are not specialists in computer science. We give explanations of some basic and advanced protocols to receive events and how to implement them in a robotic observatory software. We describe messages such as GCN notices, VOEvents or RTML, and protocols such as CGI, HTTP, SOAP, RSS, and XMPP.


Weathering of meteorites includes a variety of chemical and mineralogical changes, including conversion of metal to iron oxides, or rust. Other changes include the devitrification of glass, especially in fusion crust. On a longer time scale, major minerals such as olivine, pyroxene, and feldspar are partially or wholly converted to various phyllosilicates. The degree of weathering of meteorite finds is often noted using a qualitative system based on visual inspection of hand specimens. Several quantitative weathering classification systems have been proposed or are currently under development. Wlotzka has proposed a classification system based on mineralogical changes observed in polished sections and Mossbauer properties of meteorite powders have also been used. In the current paper, we discuss induced thermoluminescence (TL) as an indicator of degree of weathering of individual meteorites. The quantitative measures of weathering, including induced TL, suffer from one major flaw, namely that their results only apply to small portions of the meteorite.


The study investigates the connections between tourists' hotel preferences and distance from resort expressed in meters, distance from ski lift expressed in meters, booking score, number of reviews, room type, feature of free cancellation, price expressed in Euro, type (private host/hotel), destination (ski-to-door access/travel sustainable property) from 10 highly appreciated European ski locations offered in from February 2023 by Booking, using a sustainable, electronic instrument for collecting and analyzing a large amount of data, Octoparse 8 and a multi-attribute decision model. Previous studies concerning tourist preferences and online behavior used traditional methods, such as questionnaires and surveys, being limited to a certain number of questions and respondents; thus, this study covers a research gap in the literature with regard to the use of a large amount of data, electronic instruments and multi-attribute models to rank the hotel locations, which derives from the difficulty in obtaining the necessary data to carry out an in-depth analysis. The results show that when selecting a hotel location from an exclusive ski resort, the tourists are interested in the number of reviews, the price and the distances from the resorts to the ski slopes, while the booking score is less important. This is translated into practical implications for marketers and hotel managers, presented at the end of the paper.


This research aimed at improving students' skills of writing for the eleventh grade students of SMK TI Pembangunan Cimahi through the use of peer editing. It is expected that peer editing can be used to improve the students' writing skill in recount text in SMK TI Pembangunan Cimahi. This research was an action research study that consisted of two cycles. In doing the research, the researcher involved 33 students of Class XI as the respondent of the research. The data was collected by observation and writing test. The result of this research indicated that peer editing improve student writing skill from cycle to cyle. It means peer editing technique can improve students writing skill.The researcher also found that peer editing was appropriate technique for students grade XI in SMK TI Pembangunan Cimahi. Beside of learning writing it self, by using this technique student also learnt how to be cooperative in pair, because peer editing was done by pairing. The students' writing ability in recount text improved in two cycles from 52 in cycle 1 then improved to 72 in cycle 2. The improvements of this study were particularly in students' writing on generic structure and language features of recount text.Keywords: peer editing, writing, vocational high school


In this paper, we enter into detailed analysis on how the pause duration under different prosodic boundaries are affected by various contextual factors in natural speech. To get the correlation between them, the paper calculates the mean pause duration under different prosodic boundaries. The contextual factors investigated in this paper contains both linguistic features, such as boundary types, syllable tones of boundary sides, initial and final types etc, and acoustic features, such as pitch gap across the boundary. The paper makes experiments and discussion which reveals the influence of these factors on pause duration. Based on that, the paper creates a pause duration prediction model for Mandarin speech synthesis system. The model was proved to be able to generate high quality prosody output with the listening test.


To overcome the challenges of instructing on spatial concepts remotely, we propose Virtual Demonstrator, a virtual reality (VR) presentation software for educators. Virtual Demonstrator provides a suite of tools for creating spatial presentations in VR, analogous to 2D slide-based presentation software. Within our software, Visual Elements are combined across a spatiotemporal space, with discrete states akin to presentation slides. This educational resource is designed to address a growing need to learn without physical presence, and to leverage 3D spaces for learning complex spatial concepts. A timeline expands a 3D environment into another dimension, allowing for an expanded design space.


A 65-year-old woman with well-controlled hypertension comes in for a routine checkup. During the past 10 years, she has gained 25 lb and lost 1.5 inches in height.


Conventional beamforming (CBF) is one of the most important nodes in the underwater array signal processing. For the direction of arrival (DOA) estimation, CBF is robust but it suffers from the wide beamwidths and the high sidelobe levels. The background levels of bering-time recording (BTR) using CBF algorithm are high when the signal-to-noise ratio (SNR) of the receiving data is low. This paper proposes a deconvolved conventional beamforming (ADDCBF) for suppressing the sidelobes levels of CBF in the DOA estimation. The algorithm utilizes an analogous impulse function as the point scattering function (PSF), and then the direction of the source can be estimated by iterating the azimuth spectrum of CBF based on the Richardson-Lucy (R-L) algorithm. ADDCBF yields the narrow beams and the low sidelobe levels than CBF. The performance of ADDCBF are verified by the numerical simulations and the data collected by a horizontal linear array during an experiment in the South China Sea.


Disclosed is a hemodialysis device and method capable of online measuring urea clearance index. The hemodialysis device comprises a balance cavity, a dialyzer, a first liquid suction pump and a second liquid suction pump, the first liquid suction pump is used for pumping in liquid B, the second liquid suction pump is used for pumping in liquid A, the liquid B and the liquid A are mixed to form dialysate, the dialysate after entering the balance cavity enters the dialyzer through an inlet end of the dialyzer to interact with blood of a patient, and dialysis waste liquid is generated after interaction and flows out of the dialyzer through an outlet end of the same; a first conductivity measurer is arranged on a pipeline between the balance cavity and the inlet end of the dialyzer and used for measuring a conductivity value of the dialysate before interaction, and a second conductivity measurer is arranged at the outlet end of the dialyzer and used for measuring a conductivity value of the dialysis waste liquid after interaction; the hemodialysis device further comprises a calculation module, and the calculation module calculates the urea clearance index on the basis of a difference value between the conductivity value of the dialysate before interaction and the conductivity value of the dialysis waste liquid after interaction.


The reality is that healthcare professionals know what and how to deliver quality healthcare. However, this knowledge is often not translating into practice, usually because healthcare delivery processes are not well designed to enable this to happen. Three components are integral to successful healthcare improvement. This article will discuss improving healthcare using Joseph Juran's quality trilogy (see Figure 1) and briefly describe how these together will lead to improved quality-of-care. This cannot only ensure successful implementation, but also sustainable results and continuous improvement (see Figure 2).


The background of this study was the low student learning outcomes of PPKn, from 28 students who achievedthe completeness criteria at least only 11 students (39.29%). The low student learning outcomes are caused bythe high level of individuality between students so that the achievement of competence among studentsexperiences a very distant difference. Based on this, the researchers made improvements to student learningoutcomes through the application of STAD cooperative learning models. This research is a classroom actionresearch, with the subject of class VII of SMP Negeri 3 Teluk Kuantan. The data used in this study is PPKnlearning outcomes data. The results stated that after applying the STAD type cooperative learning model studentlearning outcomes had increased in the initial data the number of students who completed were 11 students, incycle I had an increase with the number of 18 students, and in cycle II the number of students who completedcontinued to increase by the number 22 student.


Introduction. Multimedia computer-tailored (Expert System; ES)
 interventions represent a low cost, easily disseminated method of changing behaviors in a
 general population. Effectiveness has been established. However, these interventions have
 produced only small effect sizes, partially due to low participant engagement. Relational
 Agents (RA), computer-based virtual characters who can establish a personal relationship, have
 the potential to increase engagement. This paper reports the Month 12 outcomes for a RCT
 involving Relational Agents. Method. The design was 3 groups (Control, ES, RA) by 3 Occasions
 (Months 0, 12, 24). A representative USA sample (N = 1639) of individuals at risk for both
 exercise and UV protection was recruited. Results. Month 12 data demonstrated that the RA
 Intervention increased participant engagement. The average number of sessions viewed/week was
 0.048 (ES) compared to 0.142 (RA). The RA also increased satisfaction and was viewed as more
 helpful. Proportion at criteria for exercise was: Control (13.6%), ES (15.7%) and RA (16.6%).
 Conclusions. The Relational Agent Intervention has the potential to outperform the previous
 best practice for computer-based interventions.


The author examines scientific debate about Roman parade armour. So far, no criteria for definition of the Roman parade armament have been developed, therefore parade armament is often confused with equipment for hippika gymnasia. Some researchers argue that there was no parade armament in the Roman army and a soldier's parade equipment was simply his full outfit. However, the author's analysis of Herodian's text and some iconographic sources indicate that it is possible to talk about some elements of military equipment used in solemn processions (pompa). During parades, a soldier's full outfit was used, but it was supplemented with various marks of distinction, military awards, some special items of equipment, such as a short ceremonial sword of Praetorians as described by Herodian, and with expensive pieces of military equipment that were impractical to use in combat. However, at the parade these items were indispensable as indicators of the owner's status.


The Phylogenetic Evolution of the Visual System S. Vallerga. A Control View to Vision Architectures B. Zavidovique, P. Fiorini. Structure and Function in the Retina G.M. Ratto, P. Martini. Onchip Vision M. Ferretti. Panel Summary: Foveation, Logpolar Mapping and Multiscale Approaches to Early Vision H. Yeshurun, et al. Neurophysiology of the Striate Cortex A. Fiorentini. Visual Form Representation G.S. di Baja. Panel Summary: Looking for Visual Primitives C. Arcelli, et al. The Oculomotor System A. Buizza. Active Vision M. Savini. Panel Summary: Allocation of Attention in Vision S. Tanimoto, et al. New Wine in Old Barrels: Knowing How to Move Tells Us How to Perceive Movement P. Viviani. Motion Analysis A. Del Bimbo, S. Santini. Panel Summary: Dynamic Perception of the Environment W. Gerbino. Visual Cognition and Cognitive Modeling L. Magnani, et al. Models and Descriptions in Machine Vision V. Roberto. Panel Summary: Icons and Words: Metaphors and Symbolisms S. Levialdi, et al. Visual Thinking: Stability and Selforganization R. Luccio. 7 additional articles. Index.


Among specimens sent for determination by several institutions and collectors are three striking additions to our fauna which are described below.


Hierarchical PCE architecture is considered in multi-domain EONs. A novel scheme is proposed to proactively update the parent PCE using BGP-LS. Simulations show that the proposed scheme reduces blocking probability and parent PCE control load.


The application of laserbased velocimetry in experimental researches of flows is closely involved in tracking ability of particles whose density or initial velocity is different from that of fluid.The transient motion equation of small particles is analyzed for numerical investigation of particles'velocity in response to complicated flow, with particular emphasis on modification of the motion equation at high particle Reynolds number.The mathematical features of particle transient motion equation are simply clarified and a numerical method to solve it is developed.It is analytically demonstrated that at high particle Reynolds number the particle transient motion equation is a nonlinear integral equation with singularity, while it is simplified to the second Volterra integral equation when particle Reynolds number is smaller than unit.By comparison of the calculating results of particle transient motion in uniform flows with corresponding analytical and experimental results, the numerical method is verified to be well valid.


Experimental setup of long distance and high resolution single-pixel imaging system was set up. Images of natural target were obtained through 34 km outdoors horizontal atmosphere in daylight, about 0.8 m resolution was achieved. The multiple resolution level of Hadamard matrix was used as measurement basis, and owing to 25% compressive sampling and differential measuring by two photon-multiplier tubes, video frame rate of 2 Hz@128128 pixels was achieved with the proposed hardware and fast Walsh transform algorithm. An signal-to-noise ratio(SNR) was defined based on human-computer interaction interface to estimate the qualities of the recovered images. The relationship between image qualities and exposure times were researched. The proposed scheme has the potential application in long distance and high resolution infrared imaging with low cost setup.


In The Netherlands, there is an increasing interest in multiple traffic offenders. Drivers without a valid licence belong to this group. For good policy making it is important to establish the number of these offenders and to which extent they harm road safety. For this reason SWOV carried out a study into this issue. There are different forms of driving without a valid licence. In the first place, there are drivers who have never possessed a licence. Then there are drivers who drive while a measure or sanction invalidates the licence, for example in the form of a disqualification or an annulment. Finally, there are drivers who drive a car while their licence has been confiscated (by the police), withdrawn or suspended. The first research question concerns the extent to which driving without a licence takes place; in road safety research this is mostly expressed in the distance travelled in traffic. The second question concerns the (increased) crash rate per kilometre. Combining the distance travelled and the crash rate per kilometre can give an idea of the number of extra casualties due to driving without a licence and also of the effect of measures (reduction in casualties) if driving without a licence no longer happens. Both subjects, size of the problem and risk, expressed in crash rate per kilometre, will be discussed in this report. This report may be accessed by Internet users at: http://www.swov.nl/rapport/R-2010-13.pdf


Background: It is stated that spinal anesthesia may alter susceptibility to the soporific effects of sedatives. In the geriatric patients who are susceptible to midazolam, the adequate dosage of midazolam for sedation was evaluated in spinal anesthesia. Methods: ASA 1 or 2 50 elderly patients (over 65 years old) who were scheduled for lower abdominal or extremities operations, were randomly assigned into two groups. Midazolam 0.01 mg/kg was administered every 5 minutes until becoming sedated before general anesthesia in the control group, while 0.01 mg/kg was administered every 5 minutes after stabilized for 15 minutes after spinal anesthesia in the study group. Results: It took 15 5.0 minutes for the control group to fall asleep while the spinal anesthesia group showed significantly less time with 11 4.2 minutes. The total amount of midazolam administered were 1.5 0.6 mg in the control group and 1.2 0.5 mg in the study group, which showed no significance. However, the amount of midazolam compared with the body weight revealed 0.031 mg in the control group and 0.023 mg in the spinal anesthesia group suggesting significantly decreased dosage in the study group. Conclusions: Midazolam revealed significant sensitivity as well as sedative susceptibility in the elderly patients who underwent spinal anesthesia. Therefore, the dosage titration of midazolam for the elderly patients in spinal anesthesia should be carefully considered.


We conducted a case study on a small fast growing Consultancy Firm in Denmark. Our tiltle was Balancing on tight rope.


In recent years the incidence of Osteoarthritis (OA) is rising sharply, and OA is doing great harm to the health of human, so to prevent and cure this disease is important. This paper reviews the development of OA in terms of etiology, pathogenesis, prevention and treatment.


In various vegetation types in Zimbabwe, the catches of Glossina pallidipes Austen and G. morsitans morsitans Westw. (Diptera: Glossinidae) at a target baited with odour (acetone, 1‐octen‐3‐ol and two phenols) were positively correlated with catches of the same species at an unbaited net. No correlation existed between target catches and hand net catches of tsetse flies sitting on the vegetation. G. pallidipes females caught at a target and at an unbaited net were older than those caught from vegetation. Of the female G. pallidipes caught at the target, 46% were in the first 3 days of pregnancy. Of those caught at the unbaited net, significantly fewer, 21%, were in this stage. G. pallidipes males caught from vegetation contained more fat (3.07 ± 0.333 mg) than those caught at the unbaited net (2.06 ± 0.339 mg) or at the target (2.19 ± 0.218 mg). It is inferred that target catches consisted predominantly of tsetse which were already in flight when they sensed the stimuli from the target, and that target catches were biased towards female G. pallidipes in the first 3 days of pregnancy.


The direct and indirect reasons of the inclined drift haulage accident in Baiping Coal Mine are analyzed.The measures of strengthening the safe direct check,the safety education and train,building up the counterplan of the inclined drift safety device are adopted,The practice proofs that the measures is good and have value of reference.


The utility model provides a tool capable of performing mouth closing and waist clamping on detonators simultaneously. The tool comprises a locating rod, a locating nut, a fastening nut, a locating sleeve and a chuck and is characterized in that more than two elastic lugs are uniformly distributed on the inner wall of the locating sleeve along a circumferential direction. The tool has the effects that: 1, the production efficiency is greatly increased; and 2, the probability of not placing the detonators in a continuous coding sequence is ensured to be low, and the satisfaction degree of a user can be increased.


The nature of hydration around Li+ in incompletely hydrated solution was investigated by the neutron first-order difference method (Soper et al., 1977), using a time-of-flight neutron diffractometer. The authors observed, for the first time, direct evidence of Li-Cl correlations, which reflect the short-range correlations between water molecules and Li+ as well as between Cl- and Li+ within approximately 4 AA. The angle between the Li-O axis and the plane of the water molecule and the hydration number were strongly concentration dependent, even for incompletely hydrated solutions at large than approximately 25 mol.% LiCl.


Thank you for downloading a history of coal mining in great britain. Maybe you have knowledge that, people have look numerous times for their chosen books like this a history of coal mining in great britain, but end up in infectious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they cope with some infectious bugs inside their laptop. a history of coal mining in great britain is available in our digital library an online access to it is set as public so you can download it instantly. Our book servers saves in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the a history of coal mining in great britain is universally compatible with any devices to read.


We present an approach to enhance the figure of merit χ(3)/α (with χ(3) being the third-order nonlinear susceptibility and α the optical absorption coefficient) in metal-dielectric composites. Nanocomposite thin films containing metal nanoclusters were obtained by embedding gold, or gold+iron in BaTiO3 matrices using the pulsed laser deposition technique. In the optical absorption spectra, the Au:BaTiO3 films showed a strong absorption peak around 562 nm due to surface plasmon resonance of Au particles. However, when a small amount of Fe was added, the resonant absorption was quenched, and χ(3) was enhanced so that χ(3)/α was significantly increased. Our study suggests a method by which to design optical nonlinear materials with large figure of merits for practical application.


This study aims to analyze the relationship of organizational learning, knowledgesharing, knowledge sharing and its effect on human capital and organizationalinnovation. Then create a model for organizational innovation-based development ofhuman capital, knowledge sharing and organizational learning SMEs in SemarangRespondents stui entrepreneurs are leaders trained partners with a numberof 150 sampling purposive sampling method. Then to analyze the data inthis study used the Structural Equation Modeling (SEM) with AMOS softwareThe results of this study suggest that innovation-based organizations to develop human capital, knowledge sharing and organizational learning, organizational innovation first built with human capital that is influenced by increasing organizational learning. The second innovation is built with a knowledge sharing organization. The third innovation is built with human capital organization.


(0.97-x)BiScO3-xPbTiO3-0.03Pb(Mn1/3Nb2/3)O3 (BS-PT-PMN) (x=0.54, 0.56, 0.58, 0.59, 0.60, and 0.62) ceramics were prepared by traditional solid state reaction method. The high Curie temperature Tc, large piezoelectric constant d33 and high mechanical factor Qm were obtained in the ternary solid solutions at the same time. X-ray diffraction analysis revealed that the morphotropic phase boundary (MPB) separating rhombohedral and tetragonal phase was found at x= 0.58. Values of the dielectric constant εr dielectric loss tanθ at 1kHz, Curie temperature Tc, piezoelectric constant d33 and for the composition x=0.58 were of 710, 0.015, 437°C, 300 C/N and 200, respectively. Temperature-dependent electromechanical coupling coefficient were stable from room temperature up to 400°C, about 250°C higher than that of conventional Pb(Zr, Ti)O3 (PZT) piezoelectric ceramics. These results indicated BS-PT-PMN ceramics could be promising candidates for high temperature and high power piezoelectric applications.


The present invention, (+) - (2S, 3S) -2- (3- chlorophenyl) -3,5,5 novel use of trimethyl-2-morpholinol, in particular, their use and the period in the treatment of restless leg syndrome associated with its use in the treatment of sexual limb movement disorder (PLMD).


In this study two-dimensional FTIR analysis was applied to understand the temperature effects on processing cellulose solutions in imidazolium-based ionic liquids. Analysis of the imidazolium ion νC2–H peak revealed hydrogen bonding within cellulose solutions to be dynamic on heating and cooling. The extent of hydrogen bonding was stronger on heating, consistent with greater ion mobility at higher temperature when the ionic liquid network structure is broken. At ambient temperatures a blue shifted νC2–H peak was indicative of greater cation-anion interactions, consistent with the ionic liquid network structure. Both cellulose and water further impact the extent of hydrogen bonding in these solutions. The FTIR spectral changes appeared gradual with temperature and contrast shear induced rheology changes which were observed on heating above 70°C and cooling below 40°C. The influence of cellulose on solution viscosity was not distinguished on initial heating as the ionic liquid network structure dominates rheology behaviour. On cooling, the quantity of cellulose has a greater influence on solution rheology. Outcomes suggest processing cellulose in ionic liquids above 40°C and to reduce the impacts of cation-anion effects and enhance solubilisation, processing should be done at 70°C.


Software definition networking is a revolutionary network architecture, which realizes the separation of the control plane and data plane of a network. While providing the centralized controllability and the software programmability, the network itself is encountering many security problems. In order to solve the problem of security threats in SDN networks, there are different layers of unique security challenges and the relevant research on SDN security problems. This paper introduces the depth learning technology into the field of security threat detection in SDN, and propose a security threat detection framework based on depth learning.The framework is based on the research on model establishment, abnormal behavior recognition and decision algorithm design. The software system based on physical memory analysis is under development in SDN. The system verifies the feasibility of this framework, and to finally generate the work plan on SDN infrastructure.


A series of three Hubble Space Telescope/Space Telescope Imaging Spectrograph spectroscopic mappings, spaced approximately one year apart, reveal three partial arcs in [Fe ii] and [Ni ii] emissions moving outward from η Carinae. We identify these arcs with the shell-like structures, seen in the three-dimensional hydrodynamical simulations, formed by compression of the primary wind by the secondary wind during periastron passages.


Background: Numerous studies pointed out that individuals suffering from personality disorders often experience limitations on a variety of life domains. These limitations are often due to an extensive treatment history. Personality disorders are characterized as pervasive and rigid, with little room for change and improvement. Young's schema therapy is proven to be effective in treating people with personality disorders. This therapy focuses on identifying and adapting early maladaptive schemas that form the base of personality pathology. Objective: The objective of the present study was to identify early maladaptive schemas in individuals suffering from personality disorders. Furthermore, this study seeked to examine life domains in which patients feel limited. Finally, the relation between maladaptive schemas and different life domains was examined. Method: Early maladaptive schemas of participants (n=35), following a group format schema therapy at Mediant de Wieke, were assessed using the Young Schema Questionnaire (YSQ). Based on patient record information, it was investigated to what extent participants experienced limitations within nine different life domains. In order to examine the relation between maladaptive schemas and life domains a Pearson's correlation was performed. Results: A majority of the participants report early maladaptive schemas from almost all schema domains. In particular the domains 'Disconnection and rejection', 'Other-directedness' and 'Negative attitude' are highly represented. Most participants experience limitations on a variety of life domains. Contrary to expectations, this study did not find a significant relation between early maladaptive schemas and difficulties on life domains. However, unpredicted significant correlations were found between specific schemas and life domains. Conclusion: The present study supports findings from prior research within this field; individuals suffering from personality disorders experience limitations on numerous life domains and are known to have an extensive treatment history. In addition, they report a large number of early, maladaptive schemas from a variety of domains. Modest positive as well as negative relations were found between specific schemas and life domains. Future research is required in order to gain further insight in these relations to broaden the existing body of research within the field of schema therapy. Furthermore, it is suggested that other schema related instruments are employed to expand current knowledge on early maladaptive schemas.


In the last issue of the Minnesota Archaeologist(Vol. 8, No. 2, April, 1942) Mr. B. W. Thayer has contributed four articles on art analysis of the erstwhile Arapaho and Cheyenne of the Minnesota prairie-woodland area and the still resident Ojibwa and Red River Cree, which bid fair to challenge attention of those who were impressed, favorably or unfavorably, with some points brought out in Dr. Steward's recent article in this journal on the historical approach to archaeology. It has for some time been an open question in the opinions of students of design in the northern sweep, from the Great Lakes to the Rockies, in how far certain distinctive traits of Plains Algonkian culture might have been carried over from older woodland residence. Mr. Thayer deals with some characteristics, interpretable by him as signs of the same, present in the moccasin structure and designing of figures in historic beadwork.


A 77 year old client for the Darwin Awards sleep-walked
his way into a swamp filled with alligators waking up face
to face with a 3 footer and surrounded by a dozen more of
the big lizards. He was able to fight them off with his
cane (which he apparently needs for sleep-walking) until
help arrived and avoided becoming gator bait.


The designation of origin (DO) defines, differentiates and protects a product that is traditionally produced in a particular geographical zone. It is widely known that DO has a positive effect on the consumer behavior. Therefore, the DO acts as a guarantee of quality, origin and tradition of the products. But with regard to local consumers, little is known about the effects that this geographical indicator of quality has on their behavior. To answer the previous question, this research analyzes the behavior of the Venezuelan consumer before the DO of a traditional product: Rum, product with large production traditions, and one of the main derived from sugar cane grown in Venezuela since the sixteenth century. Statistical analysis performed by multiple variance analysis, varimax rotation and other techniques, to a sample of 224 individuals revealed as the DO has a very positive effect on the behavior of local consumers. The results showed that the local consumer associates DO mainly with the culture of the geographical area linked to the manufacture of high quality and tradition. Furthermore, it was also seen how the local consumer was strongly affected by the DO in their purchase decision process. However, this effect was strongly moderated by the provenance of the individual. In this way, and against cognitive and behavioral dimension of the buying process, the DO has a strong influence on the quality perception and attitude towards the products.


The term 'co-investment' is often perceived as referring to institutional investors investing alongside their external asset managers in companies. However, co-investment increasingly refers to investment responsibilities being shared among peer investment organizations. Indeed, in the competitive arena of institutional investment, long-term institutional investors are forming co-investment partnerships with the specific objective of deploying capital collaboratively into attractive investment opportunities. These collaborative partnerships seem to be an important means of capitalising on an investor's network. This paper thus identifies and analyses examples of the new collaborative investment vehicles being employed by institutional investors to access private market assets. In so doing, this paper tracks the initial development of a growing trend amongst institutional investors towards more efficient ways of long-term capital deployment.


Modern fashion is developed toward pursuing its functional beauty and individual formative beauty. Especially it creates original and differentiate beauty through new materials and various kind textures. Therefore, in this study, works are expressed by combining various materials by contrasting textures without influence of color-contrast with recognition of formative beauty created from contrast-harmony of textures. And also among decorative sewing techniques, tucking technique was introduced to apply on contrast-harmony. Concept and features of texture, and factors and principles of contrast-harmony were examined. Effects of texture's contrast-harmony were analyzed using specific materials. Cases of texture's contrast-harmony expressed on designers' works were analyzed. As an examination of expressive technique for texture by tucking, concept, characteristics and history of tucking were found along with direct tucking technique test. Cases of modern fashion design applying tucking technique were also analyzed. In making works, layered method and division were used for combining materials, mono tone for color and ivory, khaki, purple and black colors were used. Various materials such as chiffon, silk, organza, velvet, fur, wool, leather, and swede are used for the works. Most fabrics were combined with and without tucking. Results of the study are as follows; Firstly, it's known that texture's contrast-harmony is an unique way in modern fashion to meet variety-pursue modern people's emotions. Secondly, effects of contrast-harmony such as transparent-opaque, gloss-mat, hard-soft, rough-smooth by combining various textures by contrasting ones. Thirdly, it could transform plain texture to uneven one, thin to thick and transparent to opaque by introducing tucking technique and applying to contrast-harmony expression. Various texture effects could be also made with tuck's flexible length, intervals, directions and line allocations. Forth, for colors of the works, mono tone was used to recognize texture at first hand than color. Colors of each work were uniformed to raise contrast effects of texture without influence of color contrast.


New neutron capture cross section of 58,60Ni were measured in the energy range from 100 eV to 600 keV using the Oak Ridge Electron Linear Accelerator (ORELA). The combination of these new neutron capture data with previous transmission data allowed a resonance analysis up to 900 keV using R-matrix theory. The theoretically determined direct capture (DC) cross sections were included in the analyses. From these resonance parameters and the DC contribution, new (n,y) astrophysical reaction rates were determined over the entire energy range needed by the lastest stellar models describing the so-called weak s process. PACS numbers: 25.40.Lw, 26.20Kn, 27.40.+z, 27.50.+e, 97.10.Cv


To provide a connection control method and apparatus in a wireless communication system. A terminal (UE; user equipment) is extended connection interrupted (EAB; extended access barring) is configured to run, RRC (radio resource control) connection Cause (establishment cause) emergency call (emergency call ), incoming (MT; mobile terminating) if a connection, and a high priority connection (high priority access) of not set to any, to instruct execution of the EAB to the lower layer. .FIELD 6


The use of warm-mix asphalt (WMA) is growing across the country. A survey conducted by the National Asphalt Pavement Association found that there was a twenty-six percent increase in WMA production in the 2012 construction season when compared to 2011. A high number of papers on WMA were presented at the 2014 Transportation Research Board annual meeting. The papers presented on WMA included an evaluation of WMA performance, which found it to be comparable to the performance of hot-mix asphalt; an assessment of a WMA modifier for open-graded friction courses; examinations of the use of reclaimed asphalt pavement mixes; and a study on sustainable concrete.


Work reports the formation of LiFePO4 nanoparticles under hydrothermal method with the investigation of the synthesis conditions (temperature, duration, relative content of polyethylene glycol addition) influence on the obtained material phase composition and magnetic microstructure. The increasing of material conductivity by a formation of carbon coating around the LiFePO4 particles was studied.


The development of microsecond pulsed glow discharge atomic emission spectrometry (GD-AES) for quantitative depth profile analysis is described. The quantification method, which is based on sputtering rates, has been previously applied to depth analysis employing a dc glow discharge source. Optimal conditions of the glow discharge source, including voltage, pressure, pulse width and pulse frequency, are utilized in order to give the best depth resolution. Pulsed operation of the glow discharge affords the advantages of two additional parameters, pulse width and pulse frequency, which allow better control over the amount of sample being removed via cathodic sputtering. This allows thin layer samples to be analyzed that are very difficult using the dc source. Under the optimized parameters, thin coatings of varying depths of Cu deposited on steel were quantified. The quantitative method predicted Cu deposition depths in accord with the nominal depths.


Chemical beam epitaxy (CBE) continues to make very important advances in large-area material uniformity, process control, new precursors and device applications. The performance of CBE-prepared devices, electronic and opto-electronic, is among the best state-of-the-art and in some cases the best in their areas, such as long wavelength multi-quantum well InGaAsP/InP DFB lasers, 0.98 /spl mu/m GaAs/GaInP lasers, carbon-doped base GaAs/GaInP HBTs and InGaAs/InP HBTs and circuits.<<ETX>>


The electrical conductivity σ and the thermoelectric power S have been measured for liquid Te–Se mixtures in a wide temperature and pressure range. Substantial changes in σ and S are induced by a slight application of pressure. The region where such changes occur is determined can the concentration-temperature plane. It is suggested that the observed semiconductor to metal transition is originated from the structural change.


Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of pathogenetic therapy for acute and chronic pain associated with rheumatic diseases. It would seem that NSAIDs are well studied: their pharmacological properties are known; the fields of their applications, the efficacy of the drugs in treating various diseases and pathological conditions, possible adverse reactions (ARs), and methods for their prevention have been identified. Nevertheless, this drug group has so far remained one of the most debated topics in the international medical literature. Debates continue about the therapeutic value of NSAIDs, the ratio of their therapeutic potential and the risk of complications, and the expediency of their long use in a number of nosological entities. There are constantly reports of new studies that modify the existing view on many aspects of using NSAIDs in real clinical practice. The paper gives a brief overview of some of the most interesting and significant works on NSAIDs, which appeared in the world medical press in the past 2016.


This paper studies a self-tuning estimation problem for a multi-sensor networked linear stochastic discrete-time system with unknown packet receiving rates and unknown model parameters. Packet dropouts may occur when measurements of a sensor are transmitted to a local processor. Phenomena of packet dropouts are described by a group of Bernoulli distributed random variables. By model transformation, the identification problem of packet receiving rates is transformed into that of unknown model parameters for a new augmented system. The Recursive Extended Least Squares (RELS) algorithm is used to simultaneously identify packet receiving rates and model parameters of original systems. Using an optimal matrix-weighted fusion estimation algorithm in linear unbiased minimum variance sense, a fusion identifier of model parameters for original systems is presented. Further, a self-tuning state fusion filter is obtained by substituting identified fusion model parameters and packet receiving rates into the corresponding optimal estimation algorithms. A simulation example verifies the effectiveness of the proposed algorithms.


The aim of the study was to improve occlusal parameters, normalization of masticatory muscles function by correcting re-prosthetic treatment of patients with partial and total ceramic prostheses using different occlusal splints. The algorithm of re-prosthetic approach to occlusal adjustment and reconstruction of mandible position in patients with iatrogenic occlusal disorders was proposed. The clinical groups included 45 patients with iatrogenic occlusal disorders who used removable and fixed ceramic dental prostheses with simplified or detailed design of occlusal surface. The time of treatment using different occlusal splints was from 2 to 3.5 months what had been mentioned in patients' past case histories. Symptomatic and pathogenetic therapy was provided for additional correction of temporomandibular joint (TMJ) functions by anti-inflammatory drugs, vitamins C, D and calcium food supplements, kinesiotherapy and magnetotherapy. It was 73.6% rate of satisfactory results of treatment. Such algorithm of re-prosthetic treatment allows to normalize bioelectric activity of masticatory muscles, functional status of TMJ and occlusal relations of the teeth. Its efficiency was proven by X-Ray and functional diagnostics methods (electromyography of masticatory muscles, T-Scan III computerized occlusal analysis).


The purpose of this book is to provide a practical introduction to mixed methods research and to discuss the steps involved in designing and conducting this form of inquiry. This book admirably achieves the stated purpose and continues the tradition of clarity and accessibility established by John Creswell in his earlier books on research methods, for example; Research Design: Qualitative, Quantitative, and Mixed Methods (2003) and Qualitative Inquiry: Choosing Among Five Traditions (1998). The comprehensive and detailed Table of


In this paper, I address contemporary attacks on rationalism thanks to Rifkin's concepts of "extreme productivity" and "zero marginal cost of production" as examples of an ideological twist on genuine economic expressions. The main issue dealt with epistemological issues in the context of the contemporary communication age. It consists to clarify the relation between economic ideas and their relation to reality. To proceed accordingly, I implement a hermeneutic method applied to Rifkin's discourse. That method is grounded in the scholarly tradition of "the ordinary language philosophy". Its results proceed to show 2 distinct language games at work: 1- the neoclassical definition of marginal cost and its own logic is distinct from Rifkin's use of it. 2- Rifkin uses the expression "marginal cost" under the auspices of an ideological discourse on the demise of capitalism. 3- The confusion is based on a systematically deceptive use of scholarly referencing. I conclude by drawing some lessons for the role of a multidisciplinary defense of economic rationality in contemporary discourse.


By using the cone theory and the iteration method,it is studied the existence and uniqueness of fixed point for a class of mixed monotone operators under inferior conditions.The results presented here improve and generalize some corresponding results.


Objective:To study the immunization situation and its affecting factors in rural areas of western China.Methods:Multilevel logistic regression model was used.Results:The immunization coverage rate was high(99.0%);HBsAg carrier rate was 88.6%,which was higher than that of the other rural areas in China.The affecting factors of immunity inoculation were social economic development and service capabilities of township and county health providers.The multilevel model verified the affecting factors were social economy and social mobilization.Conclusion:Social economy with the MCH services qualities could affect the follow-up of MCH actions.


tive history. Meanwhile, monographs are rolling off the printing presses. To some extent, this reflects a post-Cold War effort to grapple with the historical analogies for our age: do we live in a unipolar era? Is Rome the precedent? Or should we think in terms of an emerging decentred set of systems of regional emporia? Gone are the underlying idealist polarities of socialism and liberalism. What we have now, it would appear from the flurry, is the triumph of the reasons of state – a vogue for what political scientists call realism. In all this quest for new universal coordinates to make sense of the big picture, what is often left out are the histories of the colonized, who more often appear as the bit-players or stage-setters for emperors from London or Beijing. What Imperial formations sets out to do is to challenge this formulation, to insist that empires are formed out of asymmetrical relationships between social and spatial parts, and do not simply radiate from the mind's eye or the interests of a centre. Moreover, these relationships belong to – and change – a set of belief systems about civilization, space, and race. The big-picture dichotomy of realist and idealist impulses is a false one. This book is the product of a series of workshops sponsored by the School for Advanced Research in New Mexico, and to some extent builds on the pioneering anthology Tensions of empire, edited by Ann Stoler and Frederick Cooper. It goes further in important respects and does not presume that empire was a western European phenomenon: the Chinese, Ottoman, Russian, and Japanese emporia join the pantheon. What motivated the participants was a desire to grapple with 'the degrees of tolerance, of difference, of domination, and of rights' that inhere in empires. Indeed, as the editors argue, they prefer the coinage 'imperial formations', to capture the dynamic of relationships between parts, over 'empire' as a thing. It is certainly a suggestive proposition and should be aligned with some of the big syntheses as a challenge for how to conduct a more global history. Imperial formations is an important contribution and a corrective to propensities to see empires with core values, interests, or institutions that simply radiate outwards, with varying capacities to fill further geographic spaces as colonies. But does it work as a volume? Not really. The result is a book that is less than the sum of its parts. Indeed, it is a book of parts. There are wonderful essays, from Makdisi's fine-grained examination of American protestants plying their bibles in the Ottoman empire, or Jane Burbank's sweep across centuries of Moscovy's habitus of creating flexible legal mechanisms to cope with far-flung and highly variegated regions and faiths, to a couple of essays about Chinese efforts to promote the idyll of racial homogeneity while trampling on and promoting its benevolence to near and distant parts (such as Tibet). Then there is a set of essays looking at the ways in which imperial ideologies or self-conceptions wracked their architects and rulers – from Irene Silverblatt's study of the Spanish Inquisition in early modern colonial settings, to Nicholas Dirks' analysis of the dust-up over Warren Hastings and the significance of scandal and moral outrage in late eighteenth-century Britain, and ending with Fred Cooper's essay on the tension between imperial subjecthood and republican citizenry in France since the Haitian Revolution. Most of the case studies are illuminating essays in their own right. But the result is a bit of a pastiche. The essays rarely 'speak' to each other. Few authors bother with the concept of 'formation', though in spirit and execution there is some tacit consistency. The section headings are arbitrary (if well turned): what does, for instance, the title of the last cluster of essays, 'New genealogies of empire', really mean? In the end, this is a book that tends to particularize each case. One is tempted to ask if this reflects the nature of the collective venture: to get away from universal postulates with which we are all too familiar, and to examine the negotiated and contested features of empire, are we inevitably bound to push the analysis inwards and make the narratives much more introspective? It is telling, for example, that 'formations' are almost entirely endogenous: no essay, the introduction included, deals with empires in relationship to each other, as highly porous, invidious, competitive, emulative, and therefore unstable constructs; this, despite the fact that Part 2 is purportedly about 'Rethinking boundaries, imaginaries, empires'. The result is paradoxical: a series of discrete, bounded studies that reify what the editors appeared to have sought to transcend.


Describes a unique experiment in safety management which has led to a significant improvement in the safety performance of work groups at the smelter of INCO Ltd in Sudbury, Canada.


Jespersen, A. and Lutzen, J. 2001. Ultrastructure of the seminal receptacle and the dimorphic sperm in the commensal bivalve Mysella bidentata (Veneroida: Galeommatoidea: Montacutidae). —Acta Zoologica (Stockholm) 82: 107–115

The seminal receptacle and the euspermatozoa and paraspermatozoa of Mysella bidentata were examined at an ultrastructural level and the results were compared with earlier findings of the same and other species of the Montacutidae. The euspermatozoon has a slender 13 µm long nucleus and a 1.1 µm long bullet-shaped acrosome. The acrosome of the paraspermatozoon is almost identical in ultrastructure to that of the euspermatozoa but is longer (1.9 µm) and more slender and is bent at an angle to the diminutive nucleus (1.1 µm long). The unpaired seminal receptacle is lined by a heavily ciliated epithelium and a non-ciliated epithelium with short and broad microvilli. Euspermatozoa only are stored in the receptacle. They are densely packed and orientated with their heads towards the non-ciliated epithelium. In this position they develop numerous extremely fine microvilli from the acrosome which apparently serve to attach them to the epithelial microvillar surface. Stored sperm may presumably remain functional for at least six months. A possible function of paraspermatozoa could be to clump sperm into sperm bags to keep them in suspension.


Bridge fender systems are used to guide vessels through navigational channels under bridges. They appear to be an attractive and inexpensive solution for protecting integrity of bridge piers. However, the fenders are not designed to withstand any lateral forces, thus their existing impact capacity is ignored in the design. The paper presents results of research efforts initiated by the Florida Department of Transportation, aimed at evaluating the impact capacity of bridge fenders, and developing possible retrofit recommendations. Project efforts were focused on computational analysis of a Jumbo Hopper barge impacting the fender system. The non-linear finite element computer code LSDYNA was adopted for analysis. Different initial velocities and impact angles were used to represent possible collision scenarios. Specific retrofit recommendations, allowing for more efficient kinetic energy absorption, were developed and compared with the original design. INTRODUCTION After thirty-five deaths and excessive damage resulting from the ship impact to the Sunshine Skyway Bridge in Tampa, Florida in 1980, the Federal Highway Administration (FHWA) and eleven state agencies funded a research project to develop design guidelines for bridge protection against such impacts. These guidelines call for design of stronger bridge components, capable of withstanding impacts, or for using protective structures (Knott and Larsen, 1990). Protective structures, built from less expensive materials than structural components of bridges, can efficiently dissipate kinetic energy during impacts. The research was motivated by an idea of utilizing existing bridge fender systems, currently used due to US Coast Guard requirements to navigate vessels through shipping channels, as protective structures (see Figure 1a). Their design didn' t consider crashworthiness due to lateral forces, thus the impact capacity of the fenders and their retrofit or redesign became the main concern. The major goal of the research was, to investigate ways to absorb as much kinetic energy of the barge, as possible using existing or redesigned structures. Moderate cost of the proposed retrofit was also an important concern in this investigation. Several impact scenarios of a vessel-structure collision were considered. A Jumbo Hopper barge was selected as the impacting vessel, being one of the most popular barge types in the US waterways system. In 1975, the market share of Jumbo Hoppers was estimated of 27% of all barges (Knott and Larsen, 1990). The collision speed was set to 1.955 m/sec (3.8 knots), as the bound value of current velocities that can be found in midland waterways in Florida. These conservative assumptions should represent most of the actual collisions that can take place.


Foreword - Peter M Senge Towards Renaissance Curriculum - Arthur L Costa and Rosemarie M Liebmann An Idea Whose Time Has Come Difficulties with the Disciplines - Arthur L Costa and Rosemarie M Liebmann Shifting Paradigms from Either/Or to Both/And - Arthur L Costa and Rosemarie M Liebmann Curriculum - Arthur L Costa A Decision-Making Process How Process Is Connected with the Human Spirit - Rosemarie M Liebmann Process as Content - Nancy Skerritt Reading as a Thinking Process - Ruth Lorig Mathematics [u/s]Is Process Education - Carol Lloyd Teaching the Process of Aesthetic Knowing and Representation - James Henderson and David Dees Problem-Based Learning and Critical Thinking in Teaching for Science Literacy - Robert Swartz Paper Thinking - Peg Luidens The Process of Writing Learning Creative Process - Louis T Coulson and Alison Strickland A Basic Life Skill Historical Inquiry - Merv Akin and Martha I Turner Above the World - Virginia Rojas When Process Is Content in Foreign Language Teaching Humor as Process - John Dyer Afterword - Lou Rubin


Innovative ceramic materials are used in a great variety of industrial applications, but up to now the wider-spread use of ceramics has been limited by the difficulties of the processing. The aim was to optimize the citrate pyrolysis, comparing the results with the traditional method used to prepare the ceramics. Garnet and lithium ferrites, barium titanate, and a superconducting oxide, YBa 2 Cu 3 O 7 (YBCO) were prepared by pyrolysis. Moreover the reactions occurring during the preparation of powders were studied. The sample density and specific surface area of the powder was measured and XRD patterns and SEM microphotographs were taken. The pyrolysis made it possible to obtain very fine grain size of the powders with controlled stoichiometry, higher reactivity and very high density. Moreover, in the case of the garnet, only one thermal cycle was necessary to obtain the sintered material


Several experiments were performed that loaded titanium samples with deuterium from the gas phase, changed the temperature of the samples over a wide range, and monitored the neutron emission. Neutron emissions in very low intensity bursts, still significantly above the background, were recorded, revealing that low-energy nuclear reactions in condensed matter can be produced at a very low rate, which occasionally can be high enough to become detectable.


We present the experience accumulated during 3 years of having performed 10 workshops related to the topics of Sexuality and Affection, offered to 175 adolescents between the ages of 13 and 19 years, from public schools within the Panamá, City Metropolitan Area and who correspond to different socioeconomical strata. Analytical information provided from the results of two questionnaires related to knowledge about the two topics, applied prior to and after the workshops is also offered.


The dimer model on a strip is considered as a Yang–Baxter integrable six vertex model at the free-fermion point with crossing parameter and quantum group invariant boundary conditions. A one-to-many mapping of vertex onto dimer configurations allows for the solution of the free-fermion model to be applied to the anisotropic dimer model on a square lattice where the dimers are rotated by compared to their usual orientation. In a suitable gauge, the dimer model is described by the Temperley–Lieb algebra with loop fugacity . It follows that the model is exactly solvable in geometries of arbitrary finite size. We establish and solve transfer matrix inversion identities on the strip with arbitrary finite width N. In the continuum scaling limit, in sectors with magnetization Sz, we obtain the conformal weights where . We further show that the corresponding finitized characters decompose into sums of q-Narayana numbers or, equivalently, skew q-binomials. In the particle representation, the local face tile operators give a representation of the fermion algebra and the fermion particle trajectories play the role of nonlocal degrees of freedom. We argue that, in the continuum scaling limit, there exist nontrivial Jordan blocks of rank 2 in the Virasoro dilatation operator L0. This confirms that, with quantum group invariant boundary conditions, the dimer model gives rise to a logarithmic conformal field theory with central charge c  =  −2, minimal conformal weight and effective central charge . Our analysis of the structure of the ensuing rank 2 modules indicates that the familiar staggered c  =  −2 modules appear as submodules.


Abstract : Three experimental studies were conducted in real-world settings in an attempt to validate the ISDP and its accompanying design prescriptions. Two different methods were used. In the first, existing instructional materials were modified on the basis of a selected prescription that resulted from an ISDP analysis of those materials. Two or more versions were compared in an experimental comparison. Method two consisted of course intervention in which a weak unit of an existing course was identified and modified via several prescriptions resulting from ISDP analysis. Test performance, affect, confidence, and time were compared for students using the revised materials and students using the original materials. When used to revise existing materials, the ISDP prescriptions produced significant differences only in the 2nd study. Failure to find the predicted results may have been a result of confounding factors in the real-world experimental situations used. Other studies have demonstrated that existing materials revised according to ISDP prescriptions can be demonstrated to produce significant increases in student performance especially if the interaction with the materials can be controlled and the tests can be revised to more adequately measure concept classification and rule-using behavior.


Ficus carica L. has fruits with an exquisite flavour, colour and aroma. However, due to its morphological characteristics, it has a limited shelf life. The objective of this research was to evaluate the effect of modified atmosphere packaging on nutraceutical quality and the overall appearance of figs stored at 1 °C. The experimental design used was completely randomized with four replications. The combined use of packaging and cold allowed to observe fruits with less weight loss and firmness, maintaining the values of citric acid and VC without significant changes. With the exception of the last evaluation period, no statistical variation was found in the content of TAn, TP and AC. On the other hand, it was also possible to observe a significant impact on the reduction of respiration and ethylene production, which could be corroborated with the conservation of sensory aspects of the fruit (texture, colour, appearance, marketing level, aroma and flavour) from very good to good. The generation of passive atmospheres (packaging) and the use of cold (1 °C) are useful tools in maintaining the nutraceutical quality and appearance of fig fruits, aspects highly appreciated by consumers and marketers of this fruit.


In NSCLC,the JAK-STAT3 and EGFR-STAT3 signal pathways are overactivated,increasing the malignant phenotype of cancer cells.The process of malignant transforming of lung cancer cells can be reversed or slowed through inhibition of the above two signal pathways.Some curative effects have achieved by using the drugs whose targets are the two signal pathways.Meanwhile,related deep research will be carried out.The effects of above two signal pathways in the development of NSCLC will be summarized in this review.


Abstract This study explored the interaction of a message appeal of online reviews and shopping orientation on perceived congruence. The effects of perceived congruence, perceived information relevance, cumulative satisfaction, and perceived risk on purchase intention were also examined. The participants with hedonic (vs. utilitarian) shopping orientation perceived higher congruence when viewing an emotional (vs. rational) review than a rational (vs. emotional) review. Perceived information relevance mediated the effects of perceived congruence on purchase intention. Cumulative satisfaction positively affected purchase intention, while the effects of perceived risk were found to be insignificant. The findings contribute to the online review literature by providing evidence of congruence effects between consumers' internal factors and review characteristics. The finding that perceived information relevance serves as an underlying mechanism of the congruence effects expands the existing knowledge of electronic word-of-mouth. Practitioners are recommended to find ways to increase perceived information relevance by tailoring to consumers' shopping orientation and utilizing the message appeal of online reviews with website designs and algorithms.


quoted testimony to the official Commission of Inquiry could well apply to Tsiolkovskii's literary activity: "The frivolity of die [literary] form must be compensated for by the solidity of the thought" (Nikolai Chernyshevskii, Wliat Is to Be Done? trans. Michael R. Katz, 1989, 22). Andrews appropriately calls them science-fiction "paeans," songs for future triumph. This book is marred only by sporadic stylistic infelicities, occasional grammatical errors, problems of diction, repetition, and even transliteration. These are matters that the author himself, or failing that, his editors, should have corrected. Alas, they did not. Otherwise, the book is both informative and provocative. Da zdravstvuel Konstantin Eduardovich!


Abstract Southern Ocean air–sea fluxes from the COADS dataset are examined for compatibility between buoyancy gain and northward Ekman transport. An analysis in density classes points to an upwelling of Upper Circumpolar Deep Water and subsequent buoyancy gain from air–sea exchange as water flows northward in the Ekman layer. The Upper Circumpolar Deep Water layer is too shallow to admit southward geostrophic flow along topography, and an eddy mass flux mechanism for southward transport in this layer to replenish the upwelling is advanced, based on observed large-scale potential vorticity gradients. Estimates of the strength and vertical structure of the meridional flow are given using repeated hydrographic sections and a new climatology.


This study was aimed analyzing the monetary crisis on financial performance and corporation value effect.This study found that the monetary crisis affect on financial performance and corporation value. The study on 50 manufacturing companies consist of 25 companies variety business and industry and pharmacist notes at Jakarta Stock Exchange from 1992 to 2002 revealed that the monetary crisis cause decrease in financial performance and corporate value. Based on before and after mean financial and Tobin 's Q ratio, it found that the monetary crisis cause decrease in financial performance especially in 1998 and corporation value from 1998 to 2002. This study also found that based on each sector, the monetary crisis affect all financial ratio at sector one, especially in 1998 and 2000 and the monetary crisis just affect debt to equity ratio from to 2002 at sector two. Beside that the monetary crisis affect corporation value of all sectors. Keywords:  Monetary crisis; financial ratio;   Tobin's  Q;  Financial Performance; Value of the firm.


410 Volume 42, Number 3 the legal context, Burke describes Miller's unrelenting work ethic and efforts to gain the players' confidence while owners portrayed him as a "Svengali who duped and manipulated his ignorant wards into thinking militancy" (123). From Miller's perspective, the reader learns about all the major milestones the Players Association accomplished under Miller's shrewd guidance. Along the way, baseball and many of its owners are revealed as arrogant, ignorant, and excessively greedy. Deserving particular attention is the chapter "Emancipation" in which Burke discusses how the visionary Miller successfully challenged the reserve clause to bring about free agency and forged a new basic agreement in which collusion by players or owners was banned. When Miller retired in 1982, the average player's salary was $326,000, up from $19,000 in 1966. The third, final, and shortest section of the biography deals with Miller's legacy and death, in 2012. Burke explores how Miller's footprint on the baseball landscape continued well beyond his retirement, such as the collusion settlements from the late 1980s and the baseball strike in 1993–94. Miller remained active professionally, serving as a consultant to the Players Association and also consulting for others unions, notably for the National Football League. Eligible to be elected to the Baseball Hall of Fame in 2003 and 2007, Miller fell short each time, drawing an outcry from players and a particularly noteworthy silence by baseball owners. To his credit, Miller maintained his modesty and refused to lash out at any group. Burke's biography of Miller is a welcomed contribution that serves as required reading for anyone interested in exploring the complexities of baseball, economics, or labor history in the 1960s through 1980s. Marvin Miller: Baseball Revolutionary will stand next to Miller's own memoir A Whole Different Ball Game (1991) as the definitive work about the union leader who changed baseball. —Gregory H. Wolf North Central College


The need to introduce digital technologies into the housing and communal services system is dictated by global trends in the development of IT technologies and artificial intelligence and has revealed the problem of insufficient legal regulation of these relations with the focus on protecting the rights of consumers of housing and communal services. Thus, it is necessary to study, analyze and compare the international experience of digitalization of relations and their legal regulation in the provision of public services with Russian experience and legislation. As a result of the study, promising directions of digitalization of relations in the housing and communal services system of Russia were identified and conclusions were drawn about the need to adopt a set of legal norms regulating relations on the digitalization of the housing and communal services system, aimed at protecting the rights of consumers of communal services and introducing conditions for the digitalization of relations between housing and communal services in the provision of communal services in the content of the principle of social equality when regulating housing relations, making an appropriate addition to the Housing Code of the Russian Federation.


Orbiter towing provides a backup reboost capability for the International Space Station (ISS). Results from recent studies are presented, showing performance, system configuration, mission operations, and programmatics. A proposed flight demonstration to mitigate risks is also discussed.


The article presents information about the relevance of implementing online learning as one of the methods of organizing the educational process. The problem of organizing online education is described. An analysis of the foreign experience of higher education institutions, structures, and organizations was carried out. The substantiation of the definition of online education: purpose, tasks, objects was carried out. An overview of popular online platforms for training was conducted. The results of a survey of the target audience (students, parents, teachers and schoolchildren) to find the most convenient platform for organizing the educational process are given. Conclusions regarding the results of the conducted research are formulated.


Behold me on my way to an Emigrant Ship, on a hot morning early in June. My road lies through that part of London generally known to the initiated as "Down by the Docks." Down by the Docks, is Home to a good many people—to too many, if I may judge from the overflow of local population in the streets—but my nose insinuates that the number to whom it is Sweet Home might be easily counted. Down by the Docks, is a region I would choose as my point of embarkation aboard ship if I were an emigrant. It would present my intention to me in such a sensible light; it would show me so many things to be run away from.


The core of "PDCA Process Model" is to put quality management assessment of every aspect into Plan,Do,Check and Action to ensure each process under the strict control,i.e.to control the whole process of the final results(talents).To improve the teaching quality management system of interdisciplinary foreign language speciality lays the foundation of effective methods to develop the interdisciplinary foreign language speciality,course teaching,and teaching standard,which helps to foster the interdisciplinary foreign language students' judging ability,independent learning,creativity and solidarity.


Starting in 1980, the Boundary Layer Research Team at the University of Wisconsin has been systematically studying the formation and evolution of nonprecipitating boundary-layer cumulus clouds (BLCu) in regions of fair weather (anticyclones) over land (Stull, 1980). Our approach is to quantify the average statistical characteristics of the surface, thermals, boundary layer, and clouds over horizontal regions of roughly 20 km in diameter. Within such a region over land, there is typically quite a variation in land use, and associated variations in surface albedo and moisture.


We study the competitive equilibrium of a market for votes where the choice is binary and it is known that a majority of the voters supports one of the two alternatives.Voters can trade votes for a numeraire before making a decision via majority rule.We identify a sufficient condition guaranteeing the existence of an ex ante equilibrium and show that the condition is satisfied with probability one in a large electorate. In equilibrium, only the most intense voter on each side demands votes, and each demands enough votes to alone control a majority. The probability of a minority victory is independent of the size of the minority and converges to one half, for any minority size, when the electorate is arbitrarily large. In a large electorate, the numerical advantage of the majority becomes irrelevant: democracy is undone by the market. JEL Classification: C62, C72, D70, D72, P16


Aims: Diabetes mellitus is associated with bone loss, increased fracture rate and reduced bone healing. Accumulation of advanced glycation end products (AGE) and associated overexpression of the receptor for AGE (RAGE) have been implicated in the pathogenesis of bone disease in diabetes. Although the AGE-RAGE interaction is well known for the sustained induction of inflammatory process, the physiologic role of RAGE in bone tissue is not clear. Remarkably, RAGE deficiency induces a proinflammatory phenotype in bones and osteoblasts. Therefore, we aimed to study the mechanism of underlying inflammatory processes in RAGE deficient osteoblasts as well as to reveal the intricate signaling events that link RAGE deficiency and inflammation in bones from RAGE knock-out (RAGE-/-) mice. Methods: Osteoblasts from wild type (WT, C57BL/6) and RAGE-/- mice were transiently transfected with different plasmids and siRNA. Reporter gene assay, western blotting, PCR, immunoprecipitation and chromatin immunoprecipitation techniques were employed to study the expression and interactions of transcription factors and coactivators involved in the signaling pathways. Results: The proinflammatory phenotype in the bones and osteoblasts from RAGE-/- mice was associated with reduced protein and gene expression and intranuclear translocation of the anti-inflammatory nuclear receptor PPAR-a. Moreover, PPAR-a activation by Wy14643 reversed inflammation in osteoblasts from RAGE-/- mice, suggesting that the lack of PPAR-a in RAGE deficiency is responsible for the proinflammatory phenotype. We therefore analyzed the PPAR-a promoter, which contains a series of Sp1 binding sites, to understand the regulation of PPAR-a gene expression. PPAR-a promoter driven reporter gene expression was much lower in RAGE-/- osteoblasts compared to WT osteoblasts. In addition, Sp1 overexpression significantly increased PPAR-a promoter activity in WT osteoblasts, but had only marginal effects in RAGE-/- osteoblasts. Sequential promoter deletions confirmed the strong Sp1 dependency in WT osteoblasts, which was largely blunted in RAGE-/- osteoblasts. However, suppression of Sp1 by siRNA transfection decreased PPAR-a promoter expression by around 50% in both WT and RAGE-/- osteoblasts. Remarkably, endogenous Sp1 gene and protein expression was similar in osteoblasts from WT and RAGE-/- mice, suggesting that a cofactor for PPAR-a gene expression is missing in RAGE-/- osteoblasts. Noteworthy, preliminary data show that the PPAR-g coactivator-1a (PGC-1a) is markedly reduced in RAGE-/- osteoblasts compared to WT osteoblasts. Conclusions: RAGE deficiency induces a proinflammatory phenotype in bones and osteoblasts through PPAR-a insufficiency. Transcription factor Sp1 is a strong regulator of PPAR-a expression however this regulation is inadequate in RAGE deficiency most likely due to the absence of an essential cofactor such as PGC-1a.


This study tested the accuracy of new 4‐dimensional fetal echocardiography to evaluate left ventricular (LV) mass in an experimental model of fetal myocardial hypertrophy.


Thank you for downloading supporting english language learners a guide for teachers and administrators. Maybe you have knowledge that, people have search hundreds times for their favorite novels like this supporting english language learners a guide for teachers and administrators, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they cope with some malicious virus inside their computer.


A "thru‐short" noise de‐embedding method for MOSFETs is presented. The capability of the "thru‐short" method has been validated through a comparison of measured and de‐embedded noise parameters using different methods. It is shown that the "thru‐short" method is reliable for on‐wafer de‐embedding of both S‐parameters and noise parameters up to 18 GHz. Noise contributions from the parasitics due to the contact pads and interconnections surrounding the MOSFET can be determined and removed accurately. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1379–1382, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24330


High school is a profoundly social experience for students. Having friends is central to being "visible"—to having an identity—in school (Eder, 1985). Social positioning, friendship groups, romance dramas, and the battle to "fit in" gain the attention and drain the energy of students far more than do academic pursuits. Schools are the environments in which youth "struggle to define themselves in relation to others" (Wilkinson & Pearson, 2009, p. 545), and as "sexuality becomes increasingly central to identity and social relationships...schools are critical social contexts in which dominant beliefs about sexuality are played out" (546). Thus, Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) youths' social relations are fraught not only with the usual adolescent tensions, but also include fears of having their sexual or gender identity discovered, of losing friends, of being marginalized. For youth who are "out," or who are judged by peers to fail in their performance of heterosexuality or hegemonic gender, taunting and harassment, isolation, and marginalization are daily occurrences (Adelman & Woods, 2006). A middle school teacher participating in this study reported her observation of peer dynamics:


Manuscript submitted 2017-04-18, revised 2017-06-08, initially accepted for publication 2017-06-08, published in October 2017. Abstract. Multilevel converters have been intensively investigated and developed since 1960s and have found successful industrial applications. The aim of this paper is to present state of the art as well as recent research and applications of cascaded multilevel converters, which are a very interesting solution for power distribution systems and renewable energy sources. Cascaded multilevel converters can easily operate at medium and high voltage based on the series connection of power modules (cells), which use standard low-voltage component configurations. Series connections of modules (cells) allow for high quality output voltages and input currents, reduction of passive components and availability of component redundancy. Due to these features the cascaded multilevel converters have been recognized as attractive solutions for high-voltage direct-current (HVDC) transmission, solid state transformers (SST) and photovoltaic (PV) systems.


Emine Sevgi Özdamer's protagonist in the tale Career of Char: Memories of Germany is 'a witness of the solitude of the German high rise dwellers'. As she goes through her daily routine she 'listens to the sounds of loneliness' and is able to inhabit only a rigidly fugitive state of mind. This fugitive mind-set seems to ripple through the collection of reviews, ideas, discussion and deliberation presented in the pages of the collaboration Australian Literature in the German Democratic Republic: Reading through the Iron Curtain, the fugitive state being one that still works to that old idea of supply and demand. Capitalistic, yes, in so far as one must sell to buy, but literature takes on a higher status than simply the paper and words on the page, and the GDR wanted ideas, cultural variances, the possibility of imagined travel to exotic places for citizens who could not leave. My aunt (born before the War in what became the GDR) remembers holidays spent at hotels by the lakes where sport was the fun and travel was never offered unless you were an Olympic medallist, or a politician. But they wanted ideas that supported their own ideology and, even better, ideas that showed how other countries behaved badly. The GDR loved to show how their sporty living (never mind that the athletes were being doped with massive doses of steroids), their equality and communist ideals, were better than the rest of the capitalist nations. My own research and subsequent writing of a novel on the GDR doping scam Theme 14.25 attempts to unpack the phrase 'rigidly fugitive'. This oxymoron bears witness to a common exilic pathology of strain and estrangement. This strain and estrangement lives within this wellput-together collection. The often reactive writing, cross examination and highly original supposition on the relationship between authorship, the state of the GDR and the reading and writing of Australia – such a bright sunlit country – brought to mind a moment when I stood, over-dressed, in a fiercely air-conditioned room on Kangaroo Island, South Australia. The blazing sun was so fierce I'd had an ice cream melt before I even unwrapped it and I'd had to shelter on my short walk from our rental accommodation to this room – to speak to a somewhat bored crowd of students who resembled a kaleidoscope of butterfly. I began to tell them about a cold damp land where people were locked away for many reasons, including daring to read the wrong book. The locations could not have been more different, and I, being second generation German, could not have felt it more keenly. How wonderful was it then, to read other thoughts on this 'rigidly fugitive' nation and the literature of Australian writers. To be part of this discussion on the GDR. Take Anna Funder as one such modern writer, who brought the GDR to


Social innovation is defined as an institutional change leading to the emergence of new routines. Providing affordable housing to low-income communities is a challenge faced by many developing countries. Mud-Concrete (MC) technology is a promising material solution recently developed to achieve sustainable goals. This paper discusses a novel finding in Engineering that could be applied to resolve a social issue integrating with architectural norms.


Description of the business concept and the business Private equity has a rich history as alternative asset class to be considered by individuals for the purposes of investment. Numerous international and local entities provide such a service for investment purposes. However, the world economic crisis of 2008 has set numerous challenges to the industry that requires a new way of investment allocation thinking. Sustainable Investors Capital (the business) (SiC) is a proposed new business based upon the principles of new private equity asset allocations investments all managed within an exclusive ultra high net worth individual (UHNWI) club membership. The most important and underlying principle of the business is based on a lower expected internal rate of return (IRR) along with the main criteria that all investments need to improve human upliftment and sustainability under the auspice of environmental, social and governance (ESG) principles in the long term as goal. Opportunity and strategy The directors of the company have performed the necessary research along with their career skills to date to assess and understand the status quo of an existing family offices, private banks and other similar industries related to private equity. In order to differentiate the strategy, an opportunity exists to invite an exclusive base of private investors. Such members can then provide the required investment capital per transaction from their personal balance sheets for all investment opportunities that are not available to the normal public. SiC will be responsible for all the components of the business management, members' liaison and executed investments. Target market and projections Market research has been based on 69 officially registered companies to the 'South African Venture Capital Association' (SAVCA) and other similar companies and entities. From this research, certain niche opportunities have been identified that have a lead to the creation of SiC to offer a service delivery to address this business void. SiC members will be strictly identified and invited to the exclusive club on the principle that each member has a net asset value in excess of R100 million with a minimum of R10 million to be Stellenbosch University http://scholar.sun.ac.za


Field research of land lots over a 4865 ha area has demonstrated that the main sources of agricultural lands infestation are raw pieces of land (inarable lands), wood lines, dirt roads or indigested manure, used as organic fertilizer. The specific weight of weeds patches around the power line support is less than 0.013% of all weeds sources, suggesting that there is a minimum damage to agricultural crops, compared to other sources of weeds distribution in the given area. The authors of the paper propose to use chemical treatment with non-selective herbicides as the most effective measure of weeds control around the utility poles, at a cost, according to the results of the research, of 0.21 rub/ha. As a result, the issue of compensation payments to agricultural producers from energy companies should be defined by the cost value of chemical treatment of agricultural lands in zones near utility poles.


Confronting the present problems of internal control of modern enterprise system,it is extremely necessary for us to establish internal control mechanism,to improve staff quality control,and to create a sound working environment so that the internal control of financial reports can meet the requirements of modern enterprise system.According to the clue from the analysis of problems to the solutions to problems,this article demonstrates the existing problems in application of internal control of financial reports under modern enterprise system in our country.


Objective To explore the effect of effective questioning on the teaching of "Toxicology" based on case-based teaching, and to accumulate experience for further promoting the reform of Toxicology. Methods We selected 317 undergraduates of preventive medicine in Grade 2012, 2013 and 2014, from Shaanxi University of Chinese Medicine as research objects. Two teaching cases were planned in the instructional design for Grade 2012, while six teaching cases were planned for Grade 2013. The instructional design for Grade 2014 implemented effective questioning on the basis of Grade 2013. The difference in test paper scores, grade point average (GPA), the difficulty level of the test paper and grade were analyzed before and after the increase of case-based teaching and effective questioning. Results The test paper scores and grade point averages increased gradually from Grades 2012, 2013 and 2014, and the difference was statistically significant (F=99.722, P<0.05; F=60.366, P<0.05). The test paper scores and grade point averages of Grades 2013 and 2014 were significantly higher than those of Grade 2012 (P<0.05), while those in Grade 2014 were higher than for Grade 2013 (P<0.05). The difficulty coefficients of undergraduates in Grades 2012, 2013 and 2014 were 0.390, 0.275 and 0.210 respectively, showing a year by year decline. The ranks of test paper scores had a statistical difference among Grades 2012, 2013 and 2014 (H=82.831, P<0.05), and there were statistical differences between every two grades (P<0.05). Conclusion The case teaching method, combined with effective questioning, significantly amended the classroom atmosphere, enhanced students' understanding and mastery of Toxicology knowledge, increased the students' ability to analyze and solve problems, and effectively improved the teaching effect of "Toxicology".


sor of art history at Duke University; his most recent publications include AvantGarde Fascism: The Mobilization of Myth, Art and Culture in France (2007) and A Cubism Reader: Documents and Criticism, 1906–1914 (2008), co-authored with Patricia Leighten. He is currently cocurating a major exhibition of British Vorticism, travelling from the Nasher Museum of Art at Duke University in Fall 2010 to the Peggy Guggenheim Collection in Venice, then Tate Britain, in 2011. The present study derives from his current book project on Vorticism, anarchism, and aestheticized violence. modernism / modernity volume seventeen, number one, pp 135–169. © 2010 the johns hopkins


The importance of maxillofacial traumatology in sporting practice is stressed. 1094 patients have been treated for eight years, emphasizing in this way the continuous and constant increase--the incidence of this kind of trauma.


The temperature dependent ultrasonic longitudinal and shear velocities propagated at 10 MHz in superconducting (Er}.xPrx)Ba2Cu30 6.9 (x — 0.0, 0.1 and 0.2) and nonsuperconducting ErBa2CuiO6.j were used to evaluate effective Gruneisen parameters (yeff) for both modes. The elastic behavior of (Er1-xPrx)Ba2Cu306.9 (x = 0.0, 0.1 and 0.2) deviates from lattice anharmonicity theoretical curve generally above 160 K. Shear elastic response for less oxygen ErBa2Cu3O6.3 is described by purely anharmonic effects throughout the temperature range of 80 K -220 K. Deviation of elastic response for the longitudinal and shear modes from vibrational anharmonicity curves is oxygen-related and may be due to a phase transition involving oxygen ordering. The calculated effective Gruneisen parameters for (Er1-xPrx)Ba2Cu306.9 (x = 0.0, 0.1 and 0.2) for both longitudinal and shear modes were found to increase with Pr content, indicating increasing anharmonicity. The influence of Pr substitution on BCS electron-phonon coupling constant and its relationship to vibrational anharmonicity is discussed.


Purpose

The main purpose of this paper is to examine the causes and interrelations between ownership composition and financial reporting quality of firms in the Asia-Pacific region.

Design/methodology/approach

The study uses panel data for 420 firms for the period 2011-2013 (three years) from Australia, Singapore, Malaysia, the Philippines and Pakistan.

Findings

Overall, the authors find that ownership concentration is positively associated with the financial reporting quality. However, institutional ownership and foreign ownership are positively associated with financial disclosure in developing countries. Further, the result indicates that institutional and public ownership is positively associated with financial reporting in developed countries. Among the control variables, the authors find that larger firms are negatively correlated with financial reporting quality in Asia-Pacific.

Originality/value

These results highlight the highly individualized effects of blockholders and the need for research to further understand the mechanisms through which shareholders impact financial reporting quality.


The rapid microminiaturization of LSI chips has encouraged the need for similarly microminiaturizing the probes of probe cards, the parts used to inspect IC chips. In response to this need, a method of producing 3-dimensional microprobes is devised by lithography and electroforming method. By examining and optimizing each part of the process, we produced a 3-dimensional microprobe with the desired shape. The pitch of this micro probes are 24 mum (straight type) and 20 mum (staggered type). The straight type micro probe dimensions are 15 mum in width, 40 mum in thickness, 1000 mum in length, 15 mum in tip thickness, and 10 mum in tip diameter. The staggered type micro probe dimensions are 30 mum in width, 40 mum in thickness, 1000 mum in length, 15 mum in tip thickness, and 15 mum in tip diameter, respectively. And the micro probe height is 155 mum. The mechanical and electrical properties of the microprobe were estimated by measuring the contact force and contact resistance. The measurement showed satisfactory results: the contact force allowed a displacement magnitude as large as 40 mum, accompanied by a satisfactory contact force of 7 mN. In addition, the contact resistance exhibited low and stable values when contact was formed on an object made of Au exhibiting a contact force of 1 mN or more, demonstrating the high potential of the prototyped microprobes.


The paper deals with the methodology of researching legal education. Paradigm and paradigm approach are considered to be promising strategies. The authors define the notions, reveal the characteristics of the paradigm, and demonstrate actualization of cross-disciplinary links in the paradigm as exemplified by legal education.


7072 Background: PI3K-δ and PI3K-γ play complementary roles in malignant B-cells and the tumor microenvironment (TME). Inhibition of PI3K-δ blocks cytokine-mediated CLL proliferation, while inhibition of PI3K-γ blocks M2 macrophage polarization and T-cell migration in vitro. Duvelisib, an oral PI3K-δ,γ inhibitor, has shown clinical activity in a phase 1 study in patients (pts) with advanced hematologic malignancies (Study IPI-145-02), including pts with relapsed/refractory (R/R) CLL (O'Brien, ASH 2014). Methods: Serum from 52 pts with R/R CLL and 30 healthy subjects (HS) was analyzed for 72 analytes (cytokines, chemokines, and matrix metalloproteinases) using Luminex xMAP technology at baseline, Cycle 1 Day 8 (C1D8), C2D1, and C3D1. Median change from baseline was analyzed for statistical significance using a paired t-test with Bonferroni correction for multiple hypotheses; threshold for reduction was ≤ 50% of baseline and for increase was ≥ 150% of baseline. Comparison between CLL and HS utilized a 2-sam...


Ionization spectra of the elements neodymium and samarium have been obtained over the wavelength range of 423-463 nm by using the technique of resonance ionization mass spectrometry (RIMS). These studies have been performed to determine the wavelengths at which ionization occurs under RIMS conditions. The observed wavelengths have been correlated where possible with allowed transitions between known electronic energy levels. RIMS have previously been applied to the measurement of isotope ratios of these rare earth elements using a single wavelength of excitation for each element. The fact that there are a number of effective wavelengths available should be of interest to other workers in the RIMS field.


As per the Internal Revenue Service: "In 2009, IRS Director, Carlos Marx Carrasco issued an early Internal Revenue report with the intention of preventing Corporate tax fraud, he inputs the size of the corporation and what this given corporation should approximately pay in taxes.

The Internal Revenue is a tax to a Company's revenue, and it's a manifestation of its wealth. Technically speaking this tax is applied to the Company's ability of generate or attract financial income, which can be produced by passive resources such as (Equity), or Active resources (direct or indirect work/investment), and Mixed Resources (result of the Company's activity = Equity + Investment). In this sequence of ideas, it must be made clear that the Internal Revenue is not applied to new contracts, but to the income that's generate d by the execution of the obligations that are a product of the newly celebrated contract. In the case of the activities that a Corporation performs, the net costs and expenditures related to the activity that generates income are considered taxable. The fact of an imposed Internal Revenue is a complex Legal fact (it's not a Legal act or business) and as such it has a financial relevance……..