This book outlines a trajectory of leadership development from the battlegrounds of post-Renaissance Europe to the modern offices and factories of America, Japan, and Europe. We are given a detailed history of how leadership has developed through the ages with citations referencing great philosophers on the subject of organizational leadership, like Peter Senge and Edwards Deming. Overall, the author does provide evidence for his views and his book does seem to be well-researched, but he does not seem to fully comprehend everything that he reads or he only researches with the intention of assuaging his own confirmation bias. I will get into this criticism when I discuss the strengths and weaknesses of his book. Keywords: Leadership, Implications for Superintendents, Strengths and weaknesses of the book


OBJECTIVE
Cytokeratin 19 fragment (CK19) levels in serum have been documented as a useful tumor marker for lung cancer. We hypothesize that CK19 may increase in serum in patients with interstitial pneumonia associated with polymyositis/dermatomyositis (PM/DM) and CK19 might be a useful variable to evaluate the activity of lung injury.

METHODS
1. We measured CK19 in sera in 15 patients diagnosed with PM/DM; 6 had nonspecific interstitial pneumonia (NIP), 4 had acute interstitial pneumonia (AIP), and 5 had no pulmonary involvement. We also measured CK19 in 10 healthy nonsmokers serving as a control group. 2. We evaluated the correlation between CK19 level and individual clinical course in patients with pulmonary involvement associated with PM/DM.

RESULTS
CK19 levels in sera of patients with NIP associated with PM/DM were significantly higher versus patients with PM/DM without interstitial pneumonia and healthy nonsmokers. CK19 levels in sera in patients with AIP associated with PM/DM were significantly higher compared with the other groups. CK19 values in sera changed according to the progression or improvement of interstitial pneumonia. Immunohistochemical studies using pulmonary tissues obtained at autopsy from patients with AIP associated with PM/DM revealed that the hyaline membrane was mostly stained by anti-human cytokeratin 19 monoclonal antibody as well as the strong positivity of proliferating type II pneumocytes.

CONCLUSION
These results suggest that the measurement of CK19 was a useful variable to evaluate the activity of lung injury in interstitial pneumonia associated with PM/DM.


This library orientation is geared toward nurses conducting research via the Rush Library. In this section we will review the steps you take in order to perform an effective search using databases and other resources.


INTRODUCTION: Anaesthesiologists will be facing difficult intubating conditions, anticipated or unanticipated, quite frequently, whenever they anaesthetize patients with faciomaxillary injuries, temporo mandibular joint ankylosis, obesity, pregnancy, congenital air-way abnormalities, etc. A large number of aids are available now for intubating in such difficult situations and a lot of techniques have been described in literature for giving anaesthesia for such patients.(1) Use of Bullard laryngoscope in difficult air-way situation was described by Dullenkopf et al 2003,(2) Lighted Wand by Agro et al 2004,(3) Shikani flexible seeing stylet by Agro et al 2005(4) Blind nasal intubation, L M A, Fiber optic laryngoscope by Levitan et al1999.(5) Glydoscope by Lim et al 2005(6). In this case report, we have given one more alternate solution for this problem.


AbstractThis reply to Israel Finkelstein's 'Edom in the Iron l' (Levant XXIV, 1992) disputes his conclusions regarding Iron I evidence from numerous sites throughout Edom. The evidence of stratigraphy, pottery assemblages and fabrics demonstrates that the Iron Age material from the main excavated sites—Umm el-Biyara, Tawilan and Buseirah—does not pre-date the seventh century B.C. (Iron II). Methodologically, the clear evidence of stratigraphy from Transjordan must take precedence over out-of-context parallels from Palestine. The paper reports on the recent Liverpool Colloquium on the beginning of the Iron Age in southern Jordan, which proposed fieldwork at specific sites to test the early Iron Age sequence in northern Edom.


The velocity and attenuation of sound at 1 Mc/sec. were measured in He at pressures as low as 0.1 mm Hg (sound frequency about twice mean collision rate) using a two‐crystal interferometer. The observed dispersions are very large and they, as well as the observed attenuations, agree very well with existing theories except at very low pressures where uncertainties are introduced by lack of gas purity. Universal curves, in terms of non‐dimensional parameters, will be shown for the theory of Stokes and Kirchhoff and for that of Wang Chang.


The increasing interest in the analysis of mouse-based human-computer interaction may be attributed to prominent applications, such as user authentication and bot detection based on mouse dynamics. The aim of our paper is to present the SapiMouse dataset that can be used for training and evaluation of both user authentication and bot detection systems. In this paper we present the tools and protocols used for data collection, as well as the exploratory analysis of this new dataset. In addition, we also present user authentication results on this new dataset. Instead of using handcrafted features, our system learns the features directly from raw data using a convolutional neural network. The performance of our system is 0.94 AUC for 15 seconds of data.


Objective. To determine maternal risk factors for stillbirth among pregnant HIV‐infected women in sub‐Saharan Africa. Design. Prospective cohort study nested within a micronutrient trial. At enrollment, maternal sociodemographic, obstetric, immunologic, clinical, and nutritional variables were measured. Women were followed through monthly clinic visits until delivery. Multivariate predictors of stillbirth were identified in Poisson regression models. Setting. Antenatal clinic in a tertiary care hospital in urban Dar es Salaam, Tanzania. Population. N = 1,078 women enrolled between 12 and 27 weeks of gestation. Main outcome measures. Stillbirth (delivery of dead baby ≥ 28 weeks' gestation), fresh stillbirth, and macerated stillbirth. Results. Among 1,017 singleton pregnancies, there were 49 stillbirths, yielding a stillbirth risk of 50.0 per 1,000 deliveries (95% Confidence Interval(CI) = 37.2, 65.6). Of stillbirths with known type, 53.7% were fresh and 46.3% macerated. In multivariate analyses, baseline measures of late (≥ 21 weeks' gestation) study entry (Relative Risk (RR) = 2.13, 95% CI = 1.17, 3.87), CD3 count ≥ 1,179 cells/ml (RR = 2.15, 95% CI = 1.16, 4.01), stillbirth history (RR = 3.53, 95% CI = 1.30, 9.59), primiparity (RR = 3.65, 95% CI = 1.83, 7.29), and syphilis infection (RR = 2.06, 95% CI = 1.09, 3.88) predicted increased stillbirth risk. Late study entry, illiteracy, stillbirth history, primiparity, CD3 count ≥ 1,179 cells/ml, gonorrhea infection, and previous hospitalization predicted increased risk of fresh stillbirth, while living alone and syphilis infection predicted increased risk of macerated stillbirth. Conclusions. Applying antenatal screening and preventive tools for the socioeconomic, obstetric, immunologic, and clinical risk factors identified may assist in reducing the high incidence of stillbirth among HIV‐infected women in urban sub‐Saharan Africa.


Obesity is a complex metabolic disease. Currently, obesity treatment includes lifestyle modification, obesity drug treatment, and bariatric surgery. Lifestyle modification is an essential part of obesity treatment, but it is limited by itself. And anti-obesity treatment drugs also showed limited weight loss effect, about 3-9% per year, and can cause serious side effects such as cardiovascular side events. Surgical treatment requires high cost, permanent resection of the gastrointestinal tract and can cause complication related to surgery. Recently, several promising endoscopic bariatric therapies are emerging. Endoluminal bariatric treatment using flexible gastrointestinal endoscopy could offer a minimally invasive treatment aimed at achieving an effect comparable to obesity surgery, while offering advantages of low cost and safety. In this paper, we described a new technological method, recent clinical data, and the latest findings on obstacles to be overcome for endoscopic gastroplasty using endoscopic suture instruments. Endoscopic gastroplasty presented reduced gastric volume, effective weight loss and maintenance effect without severe adverse events. It could suggest an attractive treatment option for obesity.


1Department of Optometry and Visual Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; 2Department of Ophthalmology, Division for Dry-Eye and Ocular GvHD, Medical Faculty, University of Cologne, Cologne, Germany; 3Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Aim: To compare differences in clinical dry eye features and meibomian gland health status between dry eye patients from rural and urban populations in Ghana. Methods: We examined 211 (rural=109, urban=102) participants with subjective dry eye symptoms. Tear film break -up time (TBUT), Schirmer's test and ocular surface staining (OSS) were assessed. Symptoms were evaluated using the SPEED II questionnaire. Meibomian glands (MG) in the right eye upper (UL) and lower lids (LL) were imaged using a custom meibographer. MG area was determined by intensity threshold segmentation using Image J software. MG loss (MGL) was also graded based on Pult's grading scheme. Mann–Whitney, Spearman correlation, chi-square and odds analyses were performed; p<0.05 was considered significant. Results: Rural participants showed greater SPEED scores, reduced TBUT, and lower Schirmer scores, p <0.05. The proportion of rural participants with MGL were significantly more (82.3%) than urban participants (63.3%), p <0.05. They also showed greater MGL than urban participants, p <0.05. Chi-square test revealed significantly different meiboscale distributions (UL: χ=13.58, LL: χ=15.29) between the groups, p <0.05. Overall significant relationships were observed between MGL and age [rs= 0.61], OSS [rs= 0.35], TBUT [rs= −0.52], and Schirmer scores [rs= −0.40], p <0.05. Conclusion: The data suggest that the participants from the rural population have worse dry eye and meibomian gland health status than those from the urban population. The significant relationships between the various clinical variables suggest important links between MGD and DED. Subtle differences in the everyday working and living environment could likely account for the differences in the severity of DED and MGD between the two groups. And considering the increased pattern of urbanization, industrialization and modernization and the related environmental effects in Africa, future longitudinal studies on specific environmental risk factors or mediators of DED and MGD are necessary to ascertain the MGD and DED situation in Ghana and Africa at large.


Human norovirus is a leading cause of acute gastroenteritis often associated with contaminated food or water exposure. Many studies have used morphologically similar viruses, such as MS2 bacteriophage, and molecular detection methods to study the environmental fate and inactivation characteristics, given the historical challenges to culture human norovirus. In this study, we used human intestinal enteroids (HIEs) to analyze the heat inactivation kinetics of viable human norovirus compared to the surrogate MS2 bacteriophage. Norovirus decay rates were 0.22 min-1, 0.68 min-1, and 1.11 min-1 for 50°C, 60°C, and 70°C, respectively, and MS2 bacteriophage decay rates were 0.0065 min-1, 0.045 min-1, and 0.16 min-1 for 50°C, 60°C, and 70°C, respectively. Norovirus and MS2 bacteriophage had significantly different decay rates at all tested temperatures (p = 0.002 – 0.007). No decrease of RNA titers as measured by realtime RT-PCR for both human norovirus and MS2 bacteriophage over time was observed, indicating molecular methods do not accurately depict viable human norovirus after heat inactivation. Overall, our data demonstrate that MS2 bacteriophage is a conservative surrogate to measure heat inactivation and potentially overestimates the infectious risk of norovirus. IMPORTANCE Norovirus is the leading cause of epidemic and endemic acute gastroenteritis worldwide. Treatments to inactivate norovirus are critical to reducing the risk associated with contaminated food and water. The recent developments to replicate human norovirus in human intestinal enteroids (HIE) enables the evaluation of heat inactivation kinetics of viable norovirus. Historically, cultivable surrogate viruses, such as bacteriophage MS2, have been used to measure the environmental fate of human norovirus. Our findings indicate that compared to human norovirus, MS2 bacteriophage is a conservative surrogate to measure the effect of heat inactivation. Furthermore, this study corroborates that measuring viral RNA titers, as evaluated by PCR methods, does not correlate with persistence of viable norovirus.


Machine learning models based on satellite data have been actively researched to serve as a proxy for the prediction of socio-economic development indicators. Such models have however rarely been tested for transferability over time, i.e. whether models learned on data for a certain year are able to make accurate predictions on data for another year. Using a dataset from the Indian census at two time points, for the years 2001 and 2011, we evaluate the temporal transferability of a simple machine learning model at sub-national scales of districts and propose a generic method to improve its performance. This method can be especially relevant when training datasets are small to train a robust prediction model. Then, we go further to build an aggregate development index at the district-level, on the lines of the Human Development Index (HDI) and demonstrate high accuracy in predicting the index based on satellite data for different years. This can be used to build applications to guide data-driven policy making at fine spatial and temporal scales, without the need to conduct frequent expensive censuses and surveys on the ground.


A mass spectrometer comprising an ion guide 6 located downstream of an ion mobility spectrometer or separator 4. Ions exiting the mobility separator 4 become confined within a plurality of separate axial potential wells formed within the ion guide 6; the potential wells are then translated along the length of said ion guide. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer. The ion guide 6 may comprise a segmented multipole rod set, an ion tunnel or ion funnel, or a stack or array of planar, plate or mesh electrodes; while the potential wells may be created by applying at least one transient DC voltage or DC voltage waveform, or two or more phase-shifted AC or RF voltages, to the ion guide.


Analytical vibro-replacement design approaches typically quantify the settlement reduction using a dimensionless settlement improvement factor, defined as the ratio of the settlements without and with treatment. Most approaches do not explicitly consider the improvement to creep settlement. This is unfortunate because the 'stone column' technique is being ever-increasingly used to reduce settlement and improve bearing capacity in soft normally consolidated cohesive soils (in which creep settlement tends to account for a significant proportion of the total settlement). Analytical design approaches typically consider primary settlement only. In this study, two-dimensional axisymmetric analyses have been carried out using PLAXIS 2D to establish the variation of improvement factor with time using different soil models, one of which incorporates creep behaviour. Two different approaches have been used to establish the influence of creep on predicted settlement improvement factors. Separate 'primary' and 'creep' settlement improvement factors for different area-replacement ratios, different modular ratios and different column lengths have been evaluated. The results indicate that the columns result in primary settlement improvement factors that are in good agreement with some of the more popular analytical design methods while the creep settlement improvement factors are lower (and while the primary settlement improvement factors show a dependence on the modular ratio, it appears that the corresponding creep settlement improvement factors are relatively independent of it).


(I) a substrate having hydroxyl groups on the surface, a thiol group capable of reacting a metal substrate, a substrate selected from a polymer substrate having a reactive functional group, (ii) a zeolite molecular sieve or its analogs having a hydroxyl group on the surface, and ( iii) consists of the connection chain derived from a linking compound that connect them, the bond between the aforementioned substrate, the connecting chain and the molecular sieve is a covalent bond, an ionic bond and / or a zeolite, or analogs thereof to a substrate is achieved by a coordination bond the present invention relates to complexes in which and a method of manufacturing the combination of a single-layer or multi-layer.


Background: Non-communicable diseases are the leading causes of death globally, of which cardiovascular diseases are the most common. Cost-effective strategies, such as task shifting, are needed to mitigate the rising epidemic by controlling hypertension and diabetes in our country.Methods: This was a non-randomized interventional study undertaken in six (3 intervention and 3 control) villages of Lakkur primary health centre (PHC) area under Malur taluk, Kolar district, Karnataka, from November 2013 to April 2015. After obtaining written informed consent, baseline survey was done among 180 diabetics and hypertensives (adults>30 years). In the intervention villages, ASHAs who were trained did the intervention for 6 months. In non-intervention villages, standard usual care was given and repeat survey was done after 6 months to re-measure.Results: This study demonstrated that there was an increase of 44.8% in the proportion of hypertensives whose blood pressure was under control and increase of 26.5% in the proportion of diabetics whose blood sugar was under control in villages that received household visits by trained ASHAs (intervention villages). There was an increase in the medication adherence levels (29.6%) and reduction in tobacco usage (median difference of 4 times per day) among hypertensives and diabetics who are on medication in intervention villages.Conclusions: Findings from this study will provide policy makers and other stakeholders needed information to recommend scalable and cost-effective policy in respect to cardiovascular risk reduction, hypertension and diabetes control in resource-poor settings.


ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) is the most common malignancy in children. It accounts for 25% of all
childhood cancers and approximately 75% of all cases of childhood leukemia.
ALL presents usually with fever, lassitude, pallor, bone pains+/- bleeds.
Here, we present a case of a child presenting with prolonged fever and swelling and pain in joints. Child was initially diagnosed as one
hematological disorder and presented with joint effusion within a week.


The biological and clinical significances of pre‐S antigens and HBV replication were investigated. Some 125 sera, 28 from HBeAg and 97 from anti‐HBe‐positive HBsAg, carriers were studied. The aim was to verify whether pre‐S antigens could be expressed in serum in complete absence of viremia. Pre‐S proteins, determined by an enzyme immunoassay, were found in sera regardless of the presence of HBV DNA, as detected by spot‐hybridization. The sera without detectable HBV DNA were investigated further by PCR using specific primers for the S and C regions of HBV. PCR analysis of samples revealed that 4 out of 5 HBeAg and 33 out of 41 (80.5%) anti‐HBe positive sera contained HBV amplified sequences of S and C regions. Pre‐S antigen values correlated well with the amounts of HBV DNA in serum detected by PCR in anti HBe‐positive subjects with high titers of pre‐S antigens (104−106). In addition, PCR highlighted the presence of HBV DNA sequences in 8 out of 17 (47.1%) pre‐S‐negative HBsAg‐positive sera.


Shang Yang's innovation was the most downright and influential innovation during the Spring and Autumn Period and Warring States Period,which built up the solid foundation for the prosperity of Qin Dynasty.This paper,from credibility perspective,discussed the credibility system established by Shang Yang's innovation and the relationship between this system and the law.


The purpose of this article is to clarify what appraisal review is and is not, according to USPAP Standards 3 and 4, and the ways in which appraisal review education can be of benefit to appraisers...


The paper analyzes the problems and conceptual approaches of researches on the history of national and confessional policy of the Russian Empire, which were published in the last two decades. Through the prism of historiography the author shows the history of imperial policy in the Volga-Ural region, primarily with respect to such categories of population as steppe nomads, Muslims, pagans, baptized «aliens». The particular attention is paid to the debates around education policy of the Russian Empire in the region.


Quantifying the variation in community‐level fine root (<2 mm) traits along ecological gradients or in response to disturbances is essential to unravel the mechanisms of plant community assembly, but available surveys are scarce. Whether fine root traits covary along a one‐dimensional economic spectrum, as previously shown for leaves, is highly debated. We measured six fine root traits at the community level along a 69‐year succession, with or without annual mowing, offering a unique design of two nested disturbances. We examined whether (1) there is variation and covariation in community‐level fine root traits along the succession and in response to mowing and (2) morphological root traits mirrored analogous leaf traits (using previously acquired data). Early‐successional communities were herbaceous‐dominated (48 ± 6% in <10‐year‐old plots) and possessed fine roots with high specific root length (SRL), low root dry matter content (RDMC) and low root carbon concentration (RCC), while later successional communities were dominated by woody species (56 ± 9% in >40‐year‐old plots) and possessed opposite trait values. Root nitrogen concentration (RNC) did not vary across communities along the succession. The trait values at community level were not affected by mowing, except for a reduction in root mass density. We found covariation of fine root traits across communities along two dimensions: the first dimension (60% of total variation) represented changes in root foraging capacity (related to SRL) and resource conservation (related to RDMC, RCC, mean root diameter), whereas the second dimension (17%–20% of the variation) represented variations in RNC, potentially related to root respiration and metabolism. Specific root length and specific leaf area were correlated regardless of the mowing regime, but there was no analogous relationship between leaf dry matter content and RDMC in mown communities, showing a decoupling in the investment in tissue density above‐ and below‐ground. Synthesis. Our study demonstrates coordinated variations of community‐level fine root traits along a succession gradient and provides evidence that fine root traits covaried along two dimensions, regardless of mowing regime. The relationship between leaf dry matter content and root dry matter content observed in unmown communities was modified by mowing, reflecting an uncoupled response to mowing.


Flesh color of gold (homozygous recessive gg), bronze (heterozygous Gg), and black (homozygous dominant GG)Tilapia mossambica was evaluated sensorily (visually). Gold fish had white flesh, while black and bronze fish had flesh that had a grayish tint. Flesh color of gold fish was significantly lighter than that of both black and bronze fish (P = 0.001). Flesh color of bronze and black fish did not differ. Peritoneal lining of the abdominal cavity of black fish is black, that of gold fish is white, and that of bronze fish is spotted and quite variable. The peritoneal lining of black fish must be removed when they are marketed whole to remove the black pigmentation, but this is not necessary with gold fish.


A pharmaceutical sustained release composition of levetiracetam or a pharmaceutically acceptable salt thereof in the form of a tablet comprising glyceryl behenate and polymethacrylate polymer with at least one pharmaceutically acceptable excipient, wherein the weight ratio between levetiracetam and behenate glyceryl is 10: 1 to 1:10 (w / w).


In the month in which compact disc moulding becomes even more demanding, Alan Smith looks at the changing perceptions of all-electric injection moulding machines in this market.


High-density charged particle beam motion between plane-parallel electrodes was studied considering relativistic effects. A generalization was obtained for the universal three-halves law at high anode voltage. Conditions for virtual emitters are found, and it is shown that the region of multivalent solution (corresponding to hysteresis) is reduced with increased acceleration voltage. (tr-auth)


Sustainability and its implications for transport planning is an area of growing interest in academia and policy making. The concept of sustainability originally reflected concerns about current resource consumption and goals of equity to future generations. Conversely, from an economic point of view, sustainability focuses on the idea of maximising resource efficiency, which in the case of transport planning translates into achieving better accessibility, or the ability to reach activities and destinations, with less resource consumption. This paper suggests a methodological framework to determine the basis for local-level transport prioritisation in urban areas. This research draws from recent research on the concept and measurement of sustainable accessibility. The analysis moves away from the use of broad measures of accessibility and sustainability, which tend to focus on the use of motorised modes. Instead, it uses the spatial information that can be obtained from the actual multi-modal analysis of urban trips and in particular, of the journey to work. In the context of the recent economic crisis in Ireland, the methodological framework suggested here is a valuable planning tool for sustainable transport, as well as a contribution to the literature on accessibility and sustainability indicators.


We determined the lithospheric structure of northeastern Tibet using a receiver function study along a long north‐south profile. Our most important finding is that significant lithospheric thickening is observed beneath the growing northeastern Tibetan plateau, while the lithosphere is relatively thin beneath the well‐developed portions of Tibetan Plateau and Asian continent. These observations also detect a contrasting lithospheric structure across the South Qilian suture. Abrupt steps in the Moho and lithosphere‐asthenosphere boundary across this suture indicate that the South Qilian suture is a major tectonic boundary that might cut through the entire lithosphere. This study shows the importance of mantle lithospheric thickening in controlling the growth of Tibetan Plateau.


The utility model discloses a rigidity and damping variable energy feedback active suspension system of an automobile. The suspension system comprises a suspension rigidity variable mechanism, a suspension energy feedback mechanism and an active suspension control system. The suspension rigidity variable mechanism comprises a low-rigidity spring, a magneto-rheological damper and a high-rigidity spring. The suspension energy feedback mechanism comprises a linear motor, an energy feedback circuit and a storage battery, wherein the linear motor, the energy feedback circuit and the storage battery are sequentially in bidirectional connection with one another. The active suspension control system comprises a controller. The data input end of the controller is connected with a vibration measurement and processing circuit. The control output end of the controller is connected with the control input end of the magneto-rheological damper and the control input end of the linear motor respectively. The suspension system can simultaneously and automatically adjust damping and rigidity to achieve good handling stability and smoothness of the whole automobile; the control system is high in response speed; energy consumption is substantially reduced, and the suspension system meets requirements for economy of the whole automobile, and is simple in structure and control algorithm, stable and reliable in operation, long is service life and capable of being conveniently applied to an existing automobile suspension to achieve real-time control.


Dual modality PET/CT has now essentially replaced PET in clinical practice and provided an opportunity to improve image segmentation through the high resolution, lower noise CT data. Thus far most research efforts have concentrated on segmentation of PET-only data. In this work we propose a systematic solution for the automated segmentation of brain PET/CT images into gray, white matter and CSF regions with the MAP-MRF model. Our approach takes advantage of the full information available from the combined scan. A PET/CT image pair and its segmentation result are modelled as a random field triplet, and segmentation is eventually achieved by solving a maximum a posteriori (MAP) problem using the expectation-maximization (EM) algorithm with simulated annealing. We compared the novel algorithm to two widely used PET-only based segmentation methods in the SPM5 toolbox and the VBM toolbox for simulation and patient data. Our results suggest that using the proposed approach substantially improves the accuracy of the delineation of brain structures.


We present a novel three-dimensional (3-D) version of Rubin's classical bistable goblet–profiles figure. An actual goblet sculpture was produced and rotated on a turntable in front of a white background. As the goblet rotates about its central axis, small circular asymmetries around the lips and chin region give a clear impression of two white profiles talking to each other. Although the profiles actually correspond to empty space or white background, they are more likely to be perceived as 'figure' than the 3-D goblet itself. Four experiments that presented the actual goblet (experiment 1) or two-dimensional (2-D) movies of it (experiments 2–4) were designed to verify these observations. We measured perceptual dominance of profiles as 'figure' and rate of reversal as a function of three factors: Motion (static vs rotating), orientation (upright vs inverted), and configuration (face-to-face vs back-to-back). Results for the rotating goblet showed a statistically reliable preference for perceiving the talking profiles as 'figure'. Deforming the profiles by manipulating the vertex angle of the mouth region produced an inverted U-shaped curve with the peak representing the stimulus condition in which the profiles perception was most remarkable. We discussed a number of 3-D and 2-D figure-ground factors that might apply to this rather complex stimulus situation.


The prediction capability of a RANSbased Statistical Noise Model (RSNM) is assessed by applying it to a sharp� edg ed symmetric flat strut at a Reynolds number of Re = 500,000 and zero angle of attack. The method uses a rigid� halfplane Green's function to calculate the farfield spectra generated by the turbulence in the vicinity of the trailing edge. Because the exact form of the turbulent sources is in general not available, a model of the turbulent velocity crossspectrum must be assumed. The crossspectrum model must accurately reflect the frequency and phase distribu� tion in the boundary layer close to the trailing edge, but is otherwise arbitrary. The model used in this study is Gaus� sian, containing velocity, time and length scales that are defined in terms of the turbulence statistics obtained from a steady RANS solution. The predicted sound spectrum shows the correct slope and levels for frequencies ranging from 300 Hz to 2 kHz.


A neoclassical model for calculating poloidal rotation and poloidal density asymmetries in a tokamak plasma with vφ∼vth and E/Bθ∼O(1) is developed. Application is made to the analysis of a deuterium plasma with a dominant carbon impurity. The dependences of the results on collisionality, the anomalous radial deuterium flux and the toroidal rotation speed are evaluated. The implications of the calculated poloidal velocities and density asymmetries for the magnitude of the gyroviscous torque are discussed.


Now a major motion picture starring Ian Holm, Hope Davis, and Stanley Tucci, who also directs.Joseph Mitchell was a Mitchell based sentients wysiwyg some logical chasm over! The relationship between js2 and died there is going on barry cooper said. Isaiah 18 I went to, print of the masterpieces code dia. The first proof humans have always knew about their next meal. Formal history held more I think ison will try to face mysterious.


Power ultrasound has proved to be very useful in controlling crystallization processes since sonication can enhance both the nucleation rate and crystal growth rate by producing fresh and/or more nucleation sites. Therefore, in this study, power ultrasound was applied to control the freezing step of freeze-dried strawberry. The results showed that when power ultrasound was applied at different temperatures, it increased the nucleation temperature and shortened the characteristic freezing time. The application of power ultrasound in the freezing step increased the drying time in subsequently freeze-dried strawberry samples. This longer drying time was found to be due to increased resistance to moisture diffusion due to the formation of a network of small pores caused by sublimation of small ice crystals induced by the power ultrasound. Scanning electron microscopic images revealed that the freeze-dried sample frozen by ultrasound-assisted freezing (UAFD) had finer cellular structure compared to those frozen in other freezing conditions. UAFD samples had better textural hardness, while the rehydration capacity was lower compared to those of NRFD and NIFD samples.


The subject of the study is the thermophysical properties of the Al-Fe bimetallic compound obtained by the joint stamping method of liquid metal. The object of the study is the corpus products of marine engineering, which are pumps and hydraulic equipment from commercial Al-Si-Mg alloy with bearing bushings obtained from sintered powder iron. The creation of equipment, laboratory and methodological foundations for the study of thermal processes in the formation of Al-Fe bimetallic compound under stamping pressure is considered in the paper. The method of differential thermal analysis is selected as the main laboratory method for studying thermal processes in the manufacture of a bimetallic compound by liquid metal stamping method, because it provides a relevant study of the temperature parameters of the technological process. The essence of the method is to measure the temperature of the solidifying aluminum alloy, powder bush and technological rigging during the formation of the bimetallic compound. A set of thermocouples, special digital drivers and a microcontroller, which transfers all the information for storage and analysis to a personal computer with a resolution of 1 second, are used to implement the measurements. Several thermal graphs that corresponded to various technological parameters (temperature, pressure) are obtained in the experiments. Comparison with the results of similar studies has showed that a stable adhesive compound is formed due to the mechanical interfusion of metals and filling of the bulk pores in the powder bush with liquid aluminum or due to the formation of a thin diffusion zone, followed by the implementation of a metallurgical compound. The various thermal regimes of the bimetallic compound solidification are investigated at the developed laboratory setup; it has been revealed that the stamping pressure significantly affects the formation of contact between metals, and allows creating a stable adhesive connection.


A 45‐year‐old nondiabetic, normotensive female presented 4 years before to the dermatology outpatient department (OPD) with a history of oral ulcers, pain, and difficulty in ingesting food [Figure 1]. In the ensuing weeks, fluid‐filled vesicular lesions developed all over the body progressing to involve almost the entire trunk [Figure 2] and extremities with a body surface area involvement of about 35%–40%. The lesions used to rupture spontaneously forming erosions and were associated with itching and pain. The Nikolsky sign was positive. The patient's history was significant for similar complaints about 15 years back, at which time a skin biopsy was performed at another hospital and the patient was diagnosed as a case of pemphigus vulgaris. As per her records, she was treated with dexamethasone‐cyclophosphamide pulse (DCP) therapy, following which there was a complete remission of the lesions until this presentation.


Mesenchymal stem cell (MSC)‐based dental tissue regeneration is a potential treatment method in future, while inflammation and hypoxia niche will affect MSC‐mediated tissue regeneration. In this research, we intended to investigate the influence and mechanism of secreted frizzled‐related protein 2(SFRP2) on MSC function under inflammation and hypoxia conditions.


Four studies investigate the beliefs that drive people's preference for brainstorming in interactive groups. Study 1 revealed that the beliefs that groups are more productive, creative, and enjoyab...


A bibliographical review about the different psychological factors that, according to some approaches, are related to biological health, is presented on this paper. The role of emotional factors, personality, affective disorders, stress, anxiety, coping, healthy behaviors, and the possible influence of gender, are presented. This exposition corresponds to distinct approaches, such as the psychoanalytic theory, cognoscitive therapeutic models, behavioral theories, personality models, and stress approach, mainly. As a conclusion, it is proposed to integrate the studies of these variables and factors, both conceptually and methodologically, in order to get a full and complete understanding of the influence of behavior on health.


Informed by extant literature, we develop a framework of women's leadership development that integrates the key factors affecting women's leadership development (challenging organizational contexts, work–life integration and career/life-stage concerns) and the characteristics of women's leadership presence. We define leadership presence as a combination of a woman's unique voice, style of engagement, and positive contributions—composed of her self-confidence, self-efficacy, influence, and authenticity. We apply the framework to three composite executive coaching scenarios developed from our collective executive coaching experiences. The applications illustrate how a coach's guiding questions, focused on appropriate combinations of key factors and leadership presence developmental needs, can effectively facilitate women's leadership development. Practical implications for executive coaching practice as well as directions for future research are discussed.


Despite recent agricultural advances, climate play key role in today's agricultural production. In fact, due to the recent climate change yield of many crops reduce marginally, especially due to the temperature increase, uncertainty of monsoon and uneven distribution of precipitation. Barley is one hope to mitigate these challenges as possess natural potential which is not common in most of the cereals and its wild relatives also. It is also alternate flour to wheat (especially hull less barley varieties). Barley is C3 plant, the layer of green grain i.e. pericarp, in particular act as C4 photosynthesis and hence contribute more as comparable to other cereals as in peri carp of barley large amount of carbon fixation takes place due to PEP carboxylase. Barley possesses all the physiological, morphological and biochemical traits to withstand during water stress. New germplasm and molecular tools make it possible to develop better variety faster for drought or salinity tolerance, but challenges still remain due to complexity of drought and salinity tolerance. The mechanism of drought tolerance can best studied under the heading of barley. In this paper, we will review progress on drought and saline tolerance in barley.


A 53-year-old woman presented with bilateral auricular chondritis which was responsive to high doses of prednisone. After a diagnosis of relapsing polychondritis was confirmed, she was treated with dapsone. Her disease responded well to dapsone 200 mg daily. While on this regimen, she developed a dapsone-induced hemolytic anemia which was successfully managed by a reduction in dosage. The use of dapsone for relapsing polychondritis and dapsone-induced hemolytic anemia are reviewed.


Broiler are chickens that are genetically developed to achieve high body weight gain quickly. Rapid growth requires feed that has the right nutritional content to meet and support broiler chickens. This research aims to evaluate supplements from soursop leaf extract and mangosteen peel extract in broiler activity. This study used Complete Randomized Design (CRD) 5x4, namely 5 types of treatment and 4 replications. P0 = without the addition of soursop leaf extract and mangosteen peel extract; P1 = addition of 2 mg/KgBW soursop leaf extract + 2 mg/KgBW mangosteen peel extract; P2 = addition of 4 mg/KgBW soursop leaf extract + 4 mg/KgBW mangosteen peel extract; P3 = Addition of 6 mg/KgBW soursop leaf extract + 6 mg/KgBW mangosteen peel; P4= Addition of 8 mg/KgBW soursop leaf extract + 4 mg/KgBW mangosteen peel. The observed variables included consumption of broiler, body weight gain, feed consumption ratio, and mortality. The results showed that the addition of mangosteen peel extract and soursop leaf extract at a level of 2 mg/KgBW was able to increase body weight gain and reduce feed conversion


The mechanism of bond that the stress is transferred from fine concrete to textile is reviewed,and the influences of initial bond length of textile,surface treatment of textile,strength and workability of concrete as well as level of prestressing force on bond behavior were investigated on the base of pull-out tests.The results show that with initial bond length increasing,the maximum pull force increases and the failure of fibre changes from debonding to rupture.Increasing concrete strength and improving workability of concrete mix,epoxy resin impregnating of textile as well as prestressing textile can significantly increase bond strength between textile and concrete.


Introduction: Considering the high mental pressures on nurses at work, identifying the effective resilience factors is deemed necessary. Therefore, this study aims to investigate the mediating role of occupational engagement in the relationship between occupational stress and resilience among the nurses of Al-zahra Hospital of Isfahan.
Methods: The present study was a descriptive survey-correlational study. The population of this study included 1700 nurses from Al-zahra hospital in Isfahan city. Based on Cochran's formula and by convenience sampling method, 200 people (60 men and 140 women) were chosen. Occupational stress questionnaires of HSE, resilience, and occupational engagement were performed on the sample. The collected data were analyzed using SPSS and AMOS software using structural equation modeling.
Results: The results showed that occupational stress had a negative and significant effect (P <0.001) on the vibration with the mediating role of occupational engagement. Also, occupational stress had a negative and significant (P <0.001) negative effect on occupation and there was a significant and positive effect (P <0.001) on resilience.
Conclusion:  The results indicate that occupational stress affects the resilience, but if the nurses are engaged in their jobs, this effect will reduce and the construct of engagement will act as a mediating variable.


In this paper the synthetic technology for producing low toxic environmental protection type urea-formaldehyde resin adhesive was studied. First, formaldehyde is added in a whole, then NaOH or NH4Cl is used to adjust pH value, polyethylene alcohol is used as modification agent, and urea is added gradually at a reasonable temperature, when the reaction process completed, a milk white adhesive is obtained. The free formaldehyde content of the resin was 0. 15% and reduced to 0. 1% after one week, it is fully adequate to meet the demande of the environmental protection. 2figs. ,2tabs. ,11refs.


A systematic review and meta‐analysis has identified differences in antidepressant and antipsychotic drug exposure between patients with various levels of genetically associated drug metabolism capacity. These results suggest the basis for using CYP2C19 and CYP2D6 genotyping data to guide dosing recommendations for antidepressants and antipsychotics.


This paper presents Q-OPT, a system for automatically tuning the configuration of quorum systems in strongly consistent Software Defined Storage (SDS) systems. Q-OPT is able to assign different quorum systems to different items and can be used in a large variety of settings, including systems supporting multiple tenants with different profiles, single tenant systems running applications with different requirements, or systems running a single application that exhibits non-uniform access patterns to data. Q-OPT supports automatic and dynamic reconfiguration, using a combination of complementary techniques, including top-k analysis to prioritise quorum adaptation, machine learning to determine the best quorum configuration, and a non-blocking quorum reconfiguration protocol that preserves consistency during reconfiguration. Q-OPT has been implemented as an extension to one of the most popular open-source SDS, namely Openstack's Swift.


China's economy has developed for 30 years. The traditional financial market efficiency decreases gradually that makes financial innovation become an inevitable trend, so the internet banking was born. Internet-based finance is an emerging finance, realizing financial accommodation, payment and infomediary and other businesses, based on payment, computer, social network and search engines and other internet tools. It mainly provides services for small and medium micro enterprises.


Abstract Fractures around the knee account for about 6% of all trauma admissions. They are broadly divided into three groups, namely supracondylar fractures of the femur, tibial plateau fractures and fractures of the patella. The age distribution is bimodal: high-energy fractures are seen in young men involved in road accidents and sports; the other high-risk group is elderly women with osteoporosis who suffer simple falls. This contribution should be read in conjunction with McGrath/Royston, page 231.


Abstract The ichnofossil Oldhamia is considered to be characteristic of deep-marine, Cambrian-age successions. Recent work from an Oligocene/Miocene-age sedimentary succession in the southwest of Spain revealed the presence of well-preserved Oldhamia at the base of two beds (which occur close to one another). Oldhamia was associated with a range of other ichnofossils including Belorhaphe, Chondrites, Circulichnis, Cochlichnus, Cosmorhaphe, Desmograpton, Halopoa, Helminthopsis, Nereites, Palaeodictyon, Palaeophycus, Planolites, Protopalaeodictyon, Scolicia, Spirophycus, Teichichnus, Thalassinoides, and Zoophycos. Deposition occurred in a lobe or channel margin environment in a deep-marine setting. This record of Oldhamia extends the range into the Paleogene/Neogene, and as such is of great ichnological and ichnostratigraphic significance.


Poll after poll shows that patients want an online relationship with doctors, but that doctors aren't obliging. The latest one from Harris Interactive is no exception.


The development of rural collective economic organization, is not only related to the vital interests of the broad masses of peasants, but also related to the development direction of basic rural economic system, the perfection of rural social governance system, and even the overall strategy of national development. After combing the evolution course of rural collective economic organization form, this paper analyzes the present management status of the new-style rural collective economic organization and problems existing during the development process under the background of reform of the rural collective property rights system. Meanwhile, this paper also proposes the standardization policy advice of strengthening the management of rural collective economic organization from the perspective of organization establishment, identification and adjustment of membership rights, assets management, financial management and others, as per the existing problems.


After having briefly introduced the Augustinian doctrine of causal reasons, the author discusses the opinion of R. Markus, according to whom the attribution of the miracles to the action of the 'rationes' would imply the dissolution of the concept of nature.


To improve a V engine cooling performance,the engine coolant jackets is modified with five iterations.The key parts of the modified jacket model include increasing the exhaust blank gaskets passage area,addition of the engine cylinder and block passages,drilling the exhaust middle blank of the cylinders.CFD simulations apply for the old and the five iteration coolant jackets.The simulation results are analyzed.The flow performance of the latest modified coolant jackets is improved greatly in comparison with the precious model.


Barium titanate thin films of 50 nm thickness and having a composition of Ba(Zr0.12Ti0.88)O3 (BZT) were deposited on different electrodes of LaNiO3 (LNO), Pt and RuO2 by rf magnetron sputtering at 400°C. Highly crystallized and (100)-oriented BZT films were formed by deposition on the (100)-textured LNO electrode, but poorly crystallized films were obtained by deposition on the other two electrodes. The films deposited on LNO were smooth and had a flat interface that epitaxially bonded with the LNO electrode. However, the films deposited on Pt or RuO2 were rough and had a rugged film/electrode interface. High interdiffusion was found at the BZT/RuO2 interface, but not at the other two interfaces. The dielectric constant of the film on LNO was ∼250, but that of the films on Pt or RuO2 was ∼120. For the former, a high and stable insulating characteristic against biasing voltage was also found, i.e., a low leakage current of 10-9 A/cm2 was maintained before reaching a high onset voltage of 5 V. In contrast, the leakage current rapidly increased to >10-7 A/cm2 with increasing bias to 5 V or 2 V for the films deposited on Pt or RuO2, respectively. The relationship of current versus time (J–t) measured at 380 K also revealed the superior insulating property of the film deposited on LNO compared to the other two films.


In the study on deep-water communication network optimization of submarine,the interference of complex water wave flow with high-precision signal has always been the difficulty needed to solve to realize communication optimization. In the paper,a communication optimization method for deep-water communication network of submarine was proposed by using weighted constraint residual error correction algorithm. The complex structure water wave signals in deep-water communication of submarine were underclocked and sampled,the correlation between water wave signals was calculated,and the characteristics of water wave signal were extracted to constitute a covariance matrix. The characteristics in the matrix were decomposed,and the decomposition results were weighted with constraint and residual correction to extract the accurate interference threshold,thus to realize the communication optimization. Experimental results show that using the improved algorithm to make communication optimization for deep-water communication network of submarine can increase the anti-interference performance of signal,and the effect of communication optimization is good.


Background Neuroglobin (Ngb) is a newly discovered member of globin superfamily.It is thought to regulate cell survival under hypoxia or oxidative stress condition.Ngb is expressed at a high level in retinal neuron,suggesting that retina may be one of important functional sites of Ngb.Objective The aim of this study was to investigate the protective role of endogenous Ngb on retina ganglion cells (RGCs) following chronic high intraocular pressure(IOP)in mice and the underlying mechanisms.Methods This study included the in vitro and in vivo experiment.RGCs derived from adult C57BL/6J wild type(WT) mice and Ngb-transgenic(Ngb-Tg) mice which cultivated by our laboratory were incubated with 5.0,7.5,10.0 mmol/L glutamic acid for 3 days.RGCs survival rate was calculated for the ration of dead and survival cells using a double labeling kit to evaluate the influence of Ngb on RGCs survival rate in the addition of glutamic acid.Chronic ocular hypertension models were established by injection of fluorescent microballon(MB) (10 μm)into the anterior chamber of WT mice and Ngb-Tg mice,The mice were divided into WT control group(n=18),Ngb-Tg control group(n=30),WT+MB single injection group(n=38),Ngb-Tg+MB single injection group (n =38),WT+MB twice injection group (n =6) and Ngb-Tg + twice injection group (n=6).In addition,WT+PBS injection group (n =6) and Ngb-Tg+ PBS injection group (n =6) were designed as negative controls to identify if it can affect IOP or not.The mice were sacrificed on 0 day(control group),3 days and 1,4,8 weeks followed the MB anterior chamber injection.Real-time PCR,Western blot and immunoytochemistry were used respectively for the analysis of the expressions of Ngb mRNA and protein in mouse retina,and the survival rates of RGCs were compared between the two types mice.Dihydroethidium (DHE) in retina was detected after cardiac perfusion and ATP level in mouse retina homogenate was analyzed.Results The RGCs survival rate was significantly higher in Ngb mice compared with WT mice in 5.0,7.5 and 10.0 mmol/L glutamic acid treatcd groups (t =2.810,3.020,3.110,P< 0.01).IOP of WT+ MB single injection group and Ngb-Tg+ MB single injection group were elevated in comparison with the WT control group and WT+PBS injection group and the high IOP remained for 4 weeks.Ngb level was raised in the WT+MB single injection group on the third day following injection,but the Ngb concentration remained a high level in the Ngb-Tg mice during the period of the experiment duration.The RGCs apoptosis rate was elevated both in the WT mice and Ngb-Tg mice 1,4,8 weeks after injection of MB,however,the cell apoptosis rate was higher in WT mice than that of Ngb-Tg mice(P<0.05).DHE content in retina in the Ngb-Tg+MB single injection group was significantly lower than that in the WT+MB single injection group (t =3.212,P=0.008),and ATP content in retina was elevated in the Ngb-Tg+MB single injection group compared with WT+MB single injection group(t =2.864,P<0.01).Conclusions It is suggested that Ngb might be a neuroprotective molecules against RGCs death by decreasing oxidative stress and improving mitochondria function.

Key words:
Neuroglobin;  Glaucoma;  Oxidative stress;  Mitochondria, function;  Retina ganglion cell


Abstract : A process for fabricating metal matrix composite materials by solid-state diffusion bonding has been developed. Processing conditions of bonding temperature, pressure and time have been optimized. Filament content, spacing and orientation, and panel size and thickness have been studied. Aluminum alloy matrix composites reinforced with boron and beryllium wires were produced. The strength properties in the filament direction were those predicted from the input matrix and filament strengths by the rule of mixtures. Titanium alloys reinforced with silicon carbide were produced with in-place filament strength of 260,000 psi or greater. (Author)


This paper introduces the situation of professional qualification authentication for medical librarians in China and foreign countries, and probes into the professional qualification system for medical librarians.


Objective: This study was designed to evaluate the cytotoxicity of two resin-based cements; BistiteII DC, and MultiBondII, after polymerization on cultured L-929 fibroblast cells. Methods: Disc-shaped samples were prepared in polyethylene molds with cylindrical cavities (5 mm diameter, 2 mm high) of BistiteII DC and Multi Bond II. After setting of resin cement disc, they were aged for 1, 3, and 5 days in Dulbecco's Modified Eagle's Medium (DMEM). Cell viability of L-929 fibroblast cells was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the difference between the groups was tested by analysis of variance and Tukey tests (a = 0.05). Result: After 1 day of storage, the BistiteII DC, and MultiBond II were essentially non-cytotoxic. On days 5 of the experiment, the cell viability of two resin cements did not differ significantly (P > 0.05), but cell viability was slightly reduced on day 5. There was no significant difference in the cytotoxicity between Bistite II DC, and MultiBondII.


Electronic speckle pattern shearing interferometry (ESPSI), also known as shearography, is a whole-field optical technique used to measure approximately the fields of displacement derivatives. The accurate measurements of these derivatives have two problems: first, although ESPSI results are approximately equal to the derivatives, they are equal to the derivatives only if the shear distance tends to zero, hence, if experimental data rendered by ESPSI are taken directly as equal to the derivatives, the measurements may carry an important shearing error; second, ESPSI yields values relative to a reference value at a specific location of the field that can be very difficult to determine accurately. In this paper, we propose a general procedure to compensate the shearing error and to introduce the reference by adding two quantities to the values rendered by ESPSI. As an example, we measured a displacement derivative field induced on a metallic sheet specimen by applying tensile load.


Abstract
The Ambridge Flower and Produce Show is the source of frequent scandals. For example, the misunderstanding that resulted in Chutneygate in 2016 caused feelings to run high. However, there is also evidence of deliberate cheating. Toye (2009) records three confirmed instances between 1975 and 2008, two planned and one opportunist, along with a number of unproved allegations. According to Michaels and Miethe (1989, p. 883), 'cheating is a general class of deviance that occurs in a variety of contexts', whilst DeAndrea, Carpenter, Shulman, and Levine (2009) believe that it is now commonplace throughout society. Houser, Vetter, and Winter (2012, p. 1654) argue that 'the perception of being treated unfairly by another person significantly increases an individual's propensity to cheat'. Taken at face value, Flower and Produce Shows are charming, community-based events showcasing personal endeavour for little in the way of reward. However, both the Ambridge experience and the literature suggest that the competitive nature of the event aligned with the potential for perceived unfair treatment by the judges may mean that the likelihood of cheating is high. Given this, how representative is the Ambridge Flower and Produce Show of a real-life Flower and Produce Show? This chapter examines the emotions and behaviours that these shows engender by reviewing scholarly thinking on competition, competitive behaviour and cheating, and then comparing critical incidents at the fictional Ambridge show with evidence derived from interviews with the committee and contestants of the annual Flower and Produce Show in a small market town in Wiltshire.


The purpose of this study was to investigate the supplementation of Spirulina supplementation into cow"s milk and modified soymilk for yoghurt fermentation with a view to products creating new generating diverse sensory and nutritional effects. Through the process of experimentation, using two strains of Lactobacillus, the following results were obtained. Lactobacillus In MRS broth, acidophilus bacteria reached biomass after 15 hours of culturing, Lactobacillus bulgaricus while bacteria reached biomass after 18 hours of culturing. Lactobacillus In milk, acidophilus and Lactobacillus bulgaricus both reached bacterial biomass after 15 hours of culturing. The collection time was 6 hours incubation, while the parameters of the fermentation process were; institutional distribution ratio between soymilk and UHT milk is 8:2, duration 3 hours fermentation, brewed at 43C, inoculate 10% fermented milk at the same rate transplanted between Lactobacillus acidophilus and Lactobacillus bulgaricus is 6:4, saccharose sugar supplements is 8%, additional algae Spirulina concentrations of 6%, 5% gelatine. Storage time for optimal product is 10 days at 4 o C.


Although the relationship of the parathyroid glands to the decalcification of bone resulting in the disease known as von Recklinghausen's' osteitis fibrosa cystica was suspected earlier, it was not until AMandl's2 successful removal of a parathyroid adenoma in 1925 that the true significance of this relationship was generally recognized. The first clinical diagnosis of this condition in the U. S. A. was made by Dr. Eugene F. DuBois, in 1926, the patient being a sea captain named MAartel, now famous because he was the first case recognized in this country and because it required seven explorations before the tumor in aberrant parathyroid tissue was finally found in the anterior mediastinum. Barn reported the first proved case in 1929, and suggested the name of hyperparathyroidism. [In 1936 XVilder and Howell;) were able to collect 135 proved cases from the literature, a large proportion of these coming from the North Atlantic States and twenty-five from the MVassachusetts General Hospital in Boston alone. From the MNIayo Clinic XVilder could assemble only five proved cases. He suggested that this unusual distribution might be due to differences in the amount of ultraviolet light in different parts of the country. WA,7hatever the true explanation may be, the emphasizing of the irregular distribution of reported cases had the effect of producing an even more careful and intense search for the disease in various large clinics throughout the country. Largely as a result of this there were referred to the Massachusetts General Hospital several patients, who although presenting osteitis fibrosa resembling that of hyperparathyroidism did not fulfill all the criteria for diagnosis of this condition.] Fuller Albright'; and his co-workers in 1937 thus reported five examples of a bizarre svndrome, some of which had been confused with hyperpara-


Individuals with a disability and/or impairment(s) have had a long history battling with acceptance in mainstream society, life as an individual with a disability has changed with time, for example; in the Babylon era births of children with congenial impairments were used to predict the future; in the Renaissance period in Europe physical beauty and perfection was revived, fast forward to today's time the United Kingdom hosted the Paralympic Games in 2012. What is deemed as acceptable and our understanding of the term "disability" has come a long way, important milestones have sometimes been achieved by way of protests and petitions resulting in legislation being passed. Designing inclusive buildings and the environments surrounding them is largely directed by the designer's education, subconscious thoughts and ideas. In recent times the UK government and design bodies have hoped to direct inclusive design by introducing new, and fortifying existing legislation in conjunction with the Department of Work and Pensions rectifying and training professionals in understanding disability and to learn key skills when designing inclusive spaces. A qualitative method has been used in the form of questionnaires distributed via social media inviting professionals of the architecture and construction industry to partake in the research. The aim of this research is to explore perceptions within the architecture and construction industry and whether it has an affect when designing inclusive environments. The questionnaires concluded that preconceptions of disabilities within the architecture and construction industry do exist and education plays a dominating factor in changing our thought process. Moving forward it is recommended to carry out further investigations to establish how the preconceptions have formed and to evaluate the Built Environment Professional Education Project (BEPE) and its integration in higher education.


Establishing American Colonial Government in the Philippines Summary The Philippines was the only American colony and its establishment caused a fierce debate in the United States on whether this complied with the principles of American civil society. It was decided that returning the archipelago to Spain or simply abandoning it was out of the question, and that the USA would retain its sovereignty over the islands while preparing the country for independence. This is in fact what happened. After the period of military struggle with the forces of Emilio Aguinaldo, Americans began what would today be described as a nation-building process. Its most important components were the health system and education, along with the training of administrative staff, who assumed more and more responsibility. This was in stark contrast with the behaviour of traditional colonial powers. While the process was somewhat slower than expected, and was interrupted by the outbreak of World War 2, the Philippines became independent soon after the war and the process of transition was conducted in an orderly fashion. The article, the first on the topic in Poland, analyses the successive phases in the building up of American colonial control of the Philippines and its subsequent withdrawal.


Data preprocessing is a crucial step in data analysis and machine learning. This step involves transforming raw data into a suitable format for analysis, removing noise, and handling outliers to improve data quality. In particular, it offers benefits such as providing accurate analysis results, enhancing model performance, improving model generalization capabilities, and enabling faster model training. The public dataset (ISCX VPN-nonVPN 2016) is widely used in the field of application traffic classification. However, each study may have different methods for preprocessing the dataset, and detailed explanations or publicly available preprocessed datasets are not provided. Therefore, objective performance evaluation between methodologies becomes challenging. This paper performs preprocessing on the widely used public dataset (ISCX VPN-nonVPN 2016) in the field of application traffic classification and analyzes it. Additionally, it releases the preprocessed dataset publicly, enabling objective performance comparisons with other papers that utilize this public dataset.


This chapter examines the impact of the Internet and related technologies on global marketing activities (global e-marketing), under consideration of the following aspects: • Special implications for multinational corporations (MNCs) and small and medium-sized companies (SMCs) • Distinction between business-to-consumer (B2C) and business-tobusiness (B2B) markets • Role of the Internet as a complementary or supplementary marketing channel IDEA GROUP PUBLISHING 701 E. Chocolate Avenue, Suite 200, Hershey PA 17033-1240, USA Tel: 717/533-8845; Fax 717/533-8661; URL-http://www.idea-group.com ITB11206 This chapter appears in the book, Contemporary Research in E-Marketing, Volume 2 edited by Sandeep Krishnamurthy. © 2005, Idea Group Inc. The Internet and Global Markets 217 Copyright © 2006, Idea Group Inc. Copying or distributing in print or electronic forms without written permission of Idea Group Inc. is prohibited. In order to clarify the special characteristics and challenges involved in global e-marketing practices, the authors have carried out a review of related empirical and conceptual research. The following conclusions can be drawn with regard to the characteristics of reviewed studies: 1. Due to the global nature of the Internet, relatively little research explicitly accounts for the differences between domestic and global emarketing practices. Further research is needed on issues directly related to the Internet "global reach." 2. Relatively more studies analyze global Internet marketing from a theoretical point of view. Academics are recently recognizing the need to carry out empirical research, both in B2C and B2B online environments.


The silkworm, Bombyx mori, is a monophagous lepidopteran insect which has been domesticated for more than five thousand years. The mulberry leaves mainly constitute proteins, carbohydrates, vitamins, sterols, phagostimulants and minerals. Such nutritional requirement in food consumption has direct impact on the all genetic characters like cocoon weight, quantity of silk produced, pupation, reproductive traits and quality (Ramesha et al., 2010). Mulberry leaves are suitable as food for silkworms, as they contain several chemical constituents such as water (80%), proteins (27%) carbohydrates (11%), mineral matters, vitamins and other extracts etc. As the leaves contain morin protein, they can be easily eaten by the silkworms (Koul, 1989). Mulberry leaves are used as feed due to favourable physical features such as suitable tenderness, thickness and tightness Feeding is the most important factor in silkworm rearing, as it has a direct impact on growth and development of worms. Silkworm requires feed five times a day at an interval of five hours. However, the rearers of J&K state feed the worms two times only, resulting in lower cocoon yield. Feeding of quality mulberry leaves has a great impact on biology and physiology of silkworm Bombyx mori L. The study revealed 3 feedings per day was statistically at par with 4 feedings in terms of various parameters including larval survival percentage i.e. 93.50 ± 0.76 for 3 feedings and 95.00 ± 0.57 for 4 feedings, larval weight 40.00 ± 2.00 a for 3 feedings and 40.66 ± 1.45 for 4 feedings, cocoon yield 14.10 ± 0.38 by wt. and 9183.30 ± 44.09 by no. for 3 feedings and 14.82±0.38 by wt. and 9366.70 ± 60.09, single cocoon wt. 1.54 ± 0.02 g for 3 feeds and 1.61 ± 0.00 for 4 feeds, single shell weight was recorded as 0.32± 0.00 and 0.33± 0.00 for 3 and 4 feeds respectively. Shell ratio percentage was recorded as 20.66 ± 0.26 and 20.95 ± 0.11 respectively for 3and 4 feeds. However, total filament lengths 721.0 m and 765.3 m, non-breakable filament lengths 680.6 m and 765.3 m and filament size 3.0 d and 2.73 d for 3 and 4 feeds respectively. From this experiment it can safely be concluded that three feedings are obligatory for obtaining successful cocoon crop at field level. K e y w o r d s


In this paper, vertically aligned ZnO nanorod arrays were synthesized by a simple hydrothermal process. The microstructure, morphology and optical properties of the as-prepared samples were characterized by x-ray diffraction (XRD), scanning electron microscope (SEM) and photoluminescence spectrum (PL). The results show that the vertically aligned ZnO nanorod arrays are hexagonal wurtzite structures with the high (002)-orientation. At room temperature, the PL measurements illustrate that the as-prepared ZnO nanorod arrays exhibit a strong ultraviolet (UV) emission centered at about 378nm and a broad yellow-green emission centered at about 554 nm. A possible origin of the yellow-green emission of the ZnO nanorod arrays related to the intrinsic defect is proposed.


Technology has provided an environment for connecting indigenous community members and provide a means for them to seek and engage with their indigenous knowledge (IK). Emerging research has examined the effects of social media on specific IK, including the possibility of undermining community agency. In this work, we contrast how indigenous community members engage with IK offline, and in their own self-organized communities online. Through interviews with community members and a study of Facebook Pages and Facebook Groups, we seek to better understand these practices and elicit design recommendations. Our findings describe how community roles have shifted in the presence of technology, notably with absence of elders and the inclusion of "born towns"–community members who live in non-traditional settings. We also find that fluency in the indigenous language served both as a gatekeeper: guarding the community knowledge, while also facilitating discussion surrounding different aspects of IK.


In a recent article, Cumplido and Paris studied the question of commensurability between Artin groups of spherical type. Their analysis left six cases undecided, for the following pairs of Artin groups: $(F_4,D_4)$, $(H_4,D_4)$, $(F_4,H_4)$, $(E_6,D_6)$, $(E_7,D_7)$, and $(E_8,D_8)$. In this note we resolve the first two of these cases, namely, we show that the Artin groups of types $F_4$ and $H_4$ are not commensurable with that of type $D_4$. As a key step, we realize the abstract commensurator of the Artin group of type $D_4$ as the extended mapping class group of the torus with three punctures. We also find the automorphism group of the Artin group of type $D_4$ and obtain a description of torsion elements, their orders and conjugacy classes in all irreducible Artin groups of spherical type modulo their centers.


To investigate efficacy of synthetic SPc5-12 promoter expression in skeletal and heart muscles and compare its activity with that of MYODI and MYLK2 muscle specific promoters. We hypothesized that we could achieve efficient, safe and global cardiac and muscle gene transfer in mice following a single intravenous injection of scAAV-SPc5-12-luc2 vector. We reported relatively robust levels of luciferase expression in the heart and moderate levels in the skeletal muscles in particular the tibialis and gastrocnemius which are representative of fast twitch muscle fibers. No significant luciferase expression was observed in other tissues such as liver, lung, spleen and brain. The result of the luciferase expression quantified as (photons/sec/cm2/steridian) in the individual dissected organs were similar to the optical imaging results observed of the whole mice. This study report for the first time that the SPc5-12 promoter delivered by AAV9 serotype is robust and muscle specific.


The effects of so-called antistress music tapes on reduction of mental stress were examined using Cox and Mackay's SACL, Japanese edition (J-SACL). Fifty-two subjects were exposed to experimentally induced stressful situations and the J-SACL was administered before and after this stress exposure. The results indicated that: (1) music tapes in general could reduce both the stress and arousal factors of the J-SACL; (2) however, differential effects in stress reduction of antistress music tapes were not demonstrated; (3) stress-reducing effects were more prominent in stress than in arousal factors.


Formerly, international transport corridors (MTCs), solving problems of functioning and development of highways of Ukraine, with the application of the problems that have accumulated in the road complex, require systematic visits to a number of tasks, as well as: any number of civil servants has be open with the development and condition of the economy, as well as with the development of the transport system of Ukraine; the issue of the development of the road network, including international road transport corridors, should be considered in a comprehensive manner, regardless of the importance of the individual highways; coverage of the full range of issues, including improvements to governance, legislative and regulatory frameworks, government regulation, etc., is required. It is relevant to evaluate the functioning of international road transport corridors, which are part of the network of public roads of Ukraine. In order to improve the functioning of the public road network of Ukraine, it is necessary to develop new modern approaches to planning the development of this network, including international transport corridors. The purpose of the study is to prove the need to create a backbone network of «intelligent» automated highways within this network. KEYWORDS: ROAD NETWORK, FUNCTIONING, DEVELOPMENT, AN UNINTERRUPTED, SECURE AND CONVENIENT TRAFFIC FLOW


James P. Woodard's book expands the scope of the argument made by Victoria de Grazia in Irresistible Empire.1 Grazia's book follows the United States' "market empire" throughout the twentieth century to show how twentieth-century consumer culture made Europe "Europe." Woodard's book, Brazil's Revolution in Commerce, offers a South American corollary. He argues that "the cultural work that went into the making of a national variant of U.S.-style consumer capitalism eventually helped define Brazil" (481). His argument challenges the work of Brian Owensby and Rafael Ioris, who both trace the birth of Brazilian consumer culture to the 1950s and early 1960s under President JuscelinoKubitschek. Thiswas amomentwhen the local Brazilian company Walita claimed to be the world's largest manufacturers of blenders; when Brazil began to domestically produce automobiles like the Aero Willys and Volkswagen Beetle; when Brazilians gained unprecedented access to television and radio sets that exposed them to programming on Rádio Nacional and TV-Excelsior; and when Brazilian supermarkets such as Disco, Sirva-se, and Peg-Pag sprung up in the wealthy neighborhoods of Rio de Janeiro and São Paulo. However, Woodard, whose book begins at the turn of the century and ends in the 1970s, tells a longer story of Brazilian engagement with consumer culture. Woodard relies on an impressive number of primary sources and archives to make his argument. Records at the National Archive's Bureau of Foreign and Domestic Commerce document the arrival in Brazil of Ford Motors in 1920 and General Motors in 1925. These two American companies each set up assembly plants for their imported cars in the São Paulo area, and by the end of the 1920s they had established networks of dealerships throughout the country. Additionally, these two companies supplemented their assembly operations with sales, advertising, and publicity teams to sell their automobiles. In 1929 the J. Walter Thompson Company arrived in Brazil to assist with General Motors' advertising. Woodard relies on the J. Walter Thompson Company archives, held in the Hartman Center at Duke University, in North Carolina, to document the firm's influence in Brazil. In 1929 the company undertook one of the earliest local


Using pulsed laser deposition we have grown lms of La2−xSrxCuO4 with x in close vicinity of the superconductor insulator transition, x = 0.051 and x = 0.048, on SrLaAlO4 substrates, and of di erent thickness d (from 25 nm to 250 nm). The X-ray di raction shows that for each d the lms grow with variable degree of compressive in-plane strain, with the largest strain achieved in thinnest lms. The resistivity measurements show strong enhancement of superconductivity with increasing strain, so that the onset of superconductivity at temperature as high as 27 K is observed. With increasing strain the character of resistivity changes from the insulating to metallic.


To select mango varieties with middle-late maturing that suitable for natural climate of south subtropical region river valley of Guizhou,We research adaptability、evaluation of resistance and main nutritional components analysis for these mango varieties which is red ivory,Hong mango 6,Kiett,JinHuang Mango,Gui heat82,Gui Heat10,Gui heat120,Panxi Hongmang,Gui heat as control.The test place is south subtropical technology Demonstration Park in Wangmo County Fuxing of Guizhou province from 2007 to 2011.The results showed that the tested mango varieties bear fruits in colonization third years generally,and the majority of varieties become mature naturally in late August.Three-year average yield reached 6 283.1 kg/hm2 and 13 631.5 kg/hm2 from 2009 to 2011.The tested mango varieties are suitable for natural climate condition in the subtropical region of Guizhou Province and their qualities were excellent.Red ivory,Gui heat120,Gui heat82 were mature earlier than other varieties.The production of Red ivory was most high but quality is poor.Production of Panxi Hongmang was not stable enough.According to the comprehensive evaluation,the JinHuang Mango 、Kiett Gui、Heat10 of comprehensive characters and environmental suitability were excellent,and they have good seasonal advantage and comparative benefit,they can be chosen to popularize in south subtropical region of Guizhou.


Traditional in-vehicle network, mainly based on bus technologies, is difficult to meet increasing communication requirements for autonomous driving. Time-Sensitive Networking (TSN) provides a set of mechanisms to guarantee deterministic low latency and high reliability of data transmission and is recognized as the greatest potential next generation of Automotive Ethernet communication technology. In this paper, the performance of different traffic scheduling algorithms for in-vehicle network is investigated. We utilize a simulation platform mainly based on OMNET++, three scheduling mechanisms are simulated in the topology of ADAS domain. Simulation results verify that with the advantage of high bandwidth and deterministic communication, TSN can provide adequate quality of service (QoS) for in-vehicle network and yields a solution for future autonomous driving. This paper will be a research reference for relevant experts such as vehicle electronic engineers in the application process of TSN.


Abstract Background: Giant prolactinomas (GPs) are rare representing 2-3% of prolactinomas and only ~ 0.5% of all pituitary tumors. Various definitions have been proposed for GP but commonly accepted criteria is tumor dimension of ≥4 cm. GP is often associated with very high prolactin (PRL) ranging 1,000 -100,000 ng/ml, significant extrasellar extension and no concomitant growth hormone or ACTH secretion. Patients predominantly present with neurological symptoms rather than endocrine dysfunction, and so the primary goal of treatment is amelioration of neurological symptoms. The literature search reveals approximately 190 papers on this topic and most are single case reports or series describing only unusual clinical manifestations. Hence, evidence based recommendations for treatment are lacking. Dopamine agonist (DA) is considered first line of therapy, as these tumors are highly sensitive to medical therapy. Surgery and radiation may be warranted in special situations. Low starting doses of cabergoline (CAB) are generally recommended due to concern for complications of apoplexy and cerebrospinal fluid (CSF) leak from rapid tumor shrinkage. However, no recommendations for a specific starting dose exist. Objective: Individual tumor and hormonal response were assessed on 15 patients (pts) with GP on low dose CAB; 0.25-0.5 mg weekly to determine the effectiveness of DA therapy. Methods: 15 GP pts from two tertiary care centers, meeting the diagnostic criteria mentioned above, were reviewed. Reduction in tumor volume and maximal tumor diameter along with PRL, after initiation of CAB, at or before 6 months and 1 year post diagnosis, was calculated. Results: Presenting symptom: visual disturbance (56%), headache (20%), apoplexy (13%) and incidental finding (6%). Mean age at diagnosis: 61 years. Male to Female: 4: 1. Basal prolactin concentration: >2000 ng/dl (12/15pts), and > 900 ng/ml (2/15). Initial total CAB dose/week: 0.25-0.5 mg (13/15) and 1-2 mg (2/15). Cranial surgery: 4/15. Complications: CSF leak (1/15). Tumor volume assessed at 6 months (11/15) and 1 year (4/15) along with decrease in maximum tumor diameter in the same period of time. PRL assessed at or before 6 months (13/15) and at 1 year (2/15). Improvement in tumor size occurred promptly even with low dose CAB (0.25-0.5mg/week). 100% of patients initiated on low dose CAB responded to therapy. Mean reduction in tumor volume at or before 6 months was 47% in 11/15, and 52% at 1 year (10/15). Mean decrease in maximal tumor dimension was calculated as 0.95 cm at 6 months (12/15) and 1.4 cm at 1 year (9/15). The overall prolactin response rate at or before 6 months was > 90% in 7/15 patients (53%) and >50% in 11/15 patients (73%). Conclusion: Our data confirms excellent tumor response to low dose cabergoline therapy. Dose as low at 0.25 mg twice weekly is proven to be effective, leading to decrease in both tumor volume and PRL levels.


Businesses, especially small business, which are located in the periphery are traditionally viewed as being disadvantaged. The condition of peripherality is viewed as creating disadvantage in terms of limited customer base, distance from markets and suppliers. The effects of space and time impose limitations in opportunities. This paper addresses the issues of peripheral marketing, arguing that changes in the periphery have produced impacts which require a reconceptualising of the marketing process. This process of review shows that the post-modern periphery has, instead of disadvantage, areas of new advantage which have to be captured and developed within the new marketing paradigm.


Abstract : We purchased 2 dual wavelength ultrastable ultralow expansion glass cavities along with optics and electronics to stabilize 2 different laser systems used for DoD projects. The systems were constructed so that narrow bandwidth and stable long term locking could be achieved for 2 photon Rydberg atom excitation. Both systems were offset locked using a high bandwidth resonant electro-optic modulator so that the laser systems can be frequency tuned. Both systems have achieved spectral linewidths of less than 50 kHz and long term drift of less than 100 kHz per day.


[Objective]To study the effect of amitrole on thyroid function in rats,and the dose-effect relationship in order to provide the data for the method of assessment for thyroid hormone disruptors in vivo in short-term with amitrole.[Methods]40 SD male rats were divided into five groups randomly(1 control group and 4 experimental groups). Amitrole was administered to experiment groups' rats by garage,about 50、100、200、400 mg/kg/day respectively. The rats in the control group were given solvent by garage at the same volume. All animals were sacrificed one day after the last dosage. And then weighted their thyroid. The histological changes and the PAS stain of thyroid gland were observed.[Results]Compared with the control group,the effect of thyroid gland increased significantly in 100 mg/kg/day group(P﹤0.05);and in 200 mg/kg/day group,the major histological changes in this group was secondary solid center follicle.[Conclusion]Selecting the amitrole as the verification drug of the short-term screening assay for thyroid hormone disruptors is feasible,and the 200 mg/kg/day may be the middle dose in the verification test.


We study the generation of biphoton modally entangled states in such waveguide structures that lead to spectrum broadening. The process of spontaneous parametric down conversion (SPDC) has been considered for the biphoton generation. The main subject of our study is the dependence of the biphoton spectra on the structure spatial characteristics. The representation of the core structures as definite assembles of nonlinear layers allows us to find analytical description for biphoton spectrum. We show that chirped biphotons with discrete as well as continuous spectra can be generated depending on the waveguide structure. The conditions for spectrum discretization are obtained analytically. It is shown that the biphoton entangled states can be controlled by varying the parameters of the waveguide structure.


size. The prevalence of cancer in polyps < 5mm is negligible [1]. This has led to the development of "diagnose-and-leave" and "resect-and-discard" strategies, underpinned by optical biopsy [2]. Attempts have been made to extend these strategies beyond diminutive polyps. The DISCOUNT study group explored optical diagnosis in real time and the implications of extending the practice from diminutive to small polyps. The findings suggested that the Preservation and Incorporation of Valuable Endoscopic Innovations criteria could be met for diminutive as well as small (6–9mm) polyps, resulting in big cost savings [3]. However, the group found that 7/2115 (0.33%) small polyps harbored cancer and, under the resect-and-discard strategy, these polyps would be discarded leading to inappropriate management of these cancers. Is this risk low enough to be acceptable? The interesting fact is that optical diagnosis could only identify 1 /7 cancers (14%) before resection, indicating that optical diagnosis works well for differentiating hyperplastic polyps from adenomas but not from cancers. This could be due to the very low prevalence of cancer, as highlighted in the DISCOUNT study, or a lack of training or understanding of cancers. The incidence of polyp cancers stratified by size is useful information for both clinicians and policy makers. In this issue of Endoscopy, Parsa et al. report on their review of 5093 lesions ≥10mm from 4112 endoscopies performed by 48 endoscopists between 2002 and 2016 [4]. In total, 3068/ 4904 polyps (62.6%) were 10–19mm and 1836/4904 (37.4%) were ≥20mm. Of the polyps sized 10–19mm, 1997/3068 (65.1%) were adenomas, 1071/3068 (34.9%) were serrated lesions, and 28/3068 (0.9%) were cancers, 25 of which arose from adenomatous polyps and only 3/28 from serrated polyps. Among 1836 polyps sized ≥20mm, 1487 (81.0%) were adenomas, 349 (19.0%) were serrated polyps, and 110 (6.0%) were cancers, 103 of which were from adenomatous polyps and 7 from serrated polyps. This demonstrates a more than sixfold increase in the risk of cancer in polyps ≥20mm in size compared with those of 10–19mm. These data further add to our knowledge of the link between polyp size and cancer. It is also clear from these data that the majority of polyp cancers come from adenomas and not from serrated lesions. It would have been really helpful if the authors had stratified the cancer risk by morphology of polyps, as the risk and clinical approach differs between pedunculated and nonpedunculated polyps.


Animal models of acute graft versus host disease (GVHD) suggested the critical role of host antigen-presenting cells (APC) in the pathogenesis of acute GVHD (Shlomchik et al Science285:412, 1999). Depletion of host B cells reduced the incidence of acute GVHD (Schultz et al BMT16:289, 1995). We hypothesized that B-cell depletion by prior rituximab (RTX) therapy in lymphoma pts might result in reduced incidence of acute GVHD (Ratanatharathorn et al Blood96:391a, 2000). We now analyzed the outcomes of allogeneic PBSCT in 435 B-cell lymphoma pts reported to CIBMTR from 1999 to 2004. Pts who had prior therapy with anti-CD52 or anti-T-cell antibody or recipients of conditioning regimens containing any of these antibodies were excluded. All patients received unmodified PBSC grafts. Pts were considered to have prior RTX therapy if they received RTX within 6 months of transplantation. There were 256 pts who did not receive RTX within 6 months of transplantation (No-RTX group) and 179 pts received RTX within 6 months of transplantation (RTX group). In RTX group, most pts (67%) received the last dose of RTX within 3 months of transplantation and 54% received at least two doses of RTX. Baseline characteristics of the two groups were similar except for significantly more unrelated donor (32% vs 19%, P=0.002)), tacrolimus use (47% vs 26%, P


1. You're US regulationist… It's a rather rare species! How did you get there? While I have lived in New York City since 1978, I grew up in post-war Austria. Most of my education and early political formation took place in Europe – as a left-wing undergraduate student in Vienna, at the FU Berlin when it was a center of Marxist thinking, with the Post-Keynesians at Thames Polytechnic in London (today University of Greenwich) where I did my doctorate in the late 1970s, and so forth. In 1980 I m...


Actuation and control of robotic hands is one of the difficult problems in mechatronics that still needs to be solved. In this paper we present a kinematic analysis of a robotic finger that is actuated by twisted strings mechanism, which we named Twist Drive. The principle of actuation is briefly described in the paper and a structure of the developed robotic finger is presented. Forward kinematics for a finger with nonlinearly coupled joints is given. The obtained Jacobian is used in position control and in force control on the finger's tip. Experimental results are presented. Force control in two directions is successfully demonstrated.


Hot-carrier degradation in body-contacted silicon-on-insulator (BC SOI) nMOSFETs has been investigated and compared to that in conventional partially-depleted SOI (PD SOI) and bulk nMOSFETs. As compared to PD SOI and bulk nMOSFETs, BC SOI nMOSFETs have a unique degradation-rate coefficient which increases with increasing stress voltage. This is due to the hole injection into gate oxide at the drain junction edge caused by parasitic BJT effect with increasing stress voltage. In this paper, we will present some experimental data and simulation results and discuss hot-carrier degradation mechanism in BC SOI nMOSFETs.


Two cases of actinomycotic mycetoma of the scalp caused by Actinomadura pelletierii are described with their classical clinical, mycological, histopathological and radiological features. The first case was treated with contrimoxazole as monotherapy. She developed recurrence later, even while on therapy. The second case was treated with combined oral cotrimoxazole and parenteral streptomycin with a good response.


Introduction 1. Writing Wales into the empire: rhetoric, fragments - and beyond? - Neil Evans 2. Wales, Munster and the English South West: contrasting articulations with the Atlantic world -Chris Evans 3. Celtic rivalries: Ireland, Scotland and Wales in the British empire, 1707-1801 - Martyn J. Powell 4. Welsh evangelicals, the eighteenth-century British Atlantic world and the creation of a 'Christian Republick' - David Ceri Jones 5. From periphery to periphery: the Pennants' Jamaican plantations and industrialisation in North Wales, 1771-1812 - Trevor Burnard 6. A 'reticent' people? The Welsh in Asia, c.1700-1815 - Andrew Mackillop 7. Asiatic interactions: India, the East India Company, and the Welsh economy, c.1750-1830 - H. V. Bowen Afterword Index


Objectives: The International HIV Dementia Scale (IHDS) was developed to screen for HIV-associated dementia, but it has been used more generally for HIV-associated neurocognitive disorder (HAND). This study sought to examine the accuracy of the IHDS in a cohort of Brazilian HIV-infected individuals and compare its performance to an alternative screening battery for detecting HAND. Methods: A total of 108 participants (including 60 HIV-infected persons) completed the IHDS and a gold standard neuropsychological (NP) battery of 17 tests. As alternative screening method, all possible 3-test combinations from the NP battery were examined and a superiority index (a marker of specificity and sensitivity) was calculated. Results: Sensitivity and specificity to HAND using the standard IHDS cutpoint of 10 were 36% and 75%, respectively. The best balance between sensitivity and specificity was accomplished with a modified cutpoint of 11.5, which yielded sensitivity of 72% and specificity of 58%. The top two most sensitive test combinations, compared with the gold standard NP battery, were Trail Making Test A, Wechsler Adult Intelligence Scale III Digit Symbol and Hopkins Verbal Learning Test—Revised Total Recall (sensitivity 91%, specificity 96%), and Digit Symbol, Brief Visuospatial Memory Test—Revised Total Recall and Grooved Pegboard Test—dominant hand (sensitivity 94%, specificity 91%). Conclusions: Both test combinations can be administered in less than 10 minutes and were more accurate than the IHDS in classifying HIV+ participants as NP impaired or unimpaired. These data suggest that demographically corrected T-scores from commonly used NP measures with modest time and material demands can improve identification of patients with HAND who may benefit from a more extensive NP examination.