In today's highly dynamic manufacturing environment smooth information flow between different operational levels, especially planning and shop floor-level, is essential to ensure rapid reaction to changes. Unfortunately, the manufacturing companies are facing challenges with their manufacturing operations and management practices and associated information systems. This came clear during the interviews conducted among 25 Finnish manufacturing companies between the late fall 2013 and spring 2014. This paper discusses the results from those company interviews, highlighting the current practices and challenges of manufacturing operations management in Finnish manufacturing companies. The main findings are the following. The production planning and control on the factory floor level are not widely supported by proper IT-tools. Utilisation of Manufacturing Operations Management (MOM) systems, including Manufacturing Execution Systems (MES) and Advanced Planning and Scheduling (APS) systems, is still rare. The detailed production scheduling, dispatching and operations control are commonly performed by various MS Excel spreadsheets and paper documents, which are not integrated with other company IT-systems and do not support rapid reaction to changes and disturbances.


Low-amplitude signal detection is a key procedure in borehole microseismic and desert seismic exploration. Usually, signals are difficult to detect due to their low amplitude and noise contamination. To solve this problem, we propose a method combining shearlet energy entropy with a support vector machine (SVM) to detect low-amplitude signals. In the proposed method, the signal feature is extracted using shearlet energy entropy. The signal is more sparsely represented in the shearlet domain because of the multi-scale and multi-direction characteristic of the shearlet transform, which favours signal feature extraction. Furthermore, in calculating shearlet energy entropy, we use the correlation of shearlet coefficients to enhance the difference between signal and noise in the shearlet domain. Shearlet energy entropy makes the SVM achieve a more accurate classification result compared with other traditional features such as amplitude and energy. The results of synthetic and field data show that our method is more effective than the STA/LTA and the convolutional neural network for low-amplitude microseismic signal and desert seismic signal detection.


A SMALL set of quartz crystals of somewhat peculiar habit, collected by Lieut. E. G. Spencer-Churchill near De Aar, South Africa, and given by him to the Mineral Department of the University Museum, present some features of interest; two crystals, in particular, are remarkable as exhibiting faces seldom observed on quartz. The first has a face X lying in the zone [mz] (or [mr] ~), the other a well-developed face in the zone [rz]. The crystal bearing the former face, X, is depicted in fig. 1. As regards habit and other features, it is in all respects similar to the second crystal (fig. 2). The faces r and z cannot be distinguished with certainty, but cleavage-cracks within the crystal point to the lettering shown in fig. 1. The polariscope proves the presence of both rightand lef~handed material. The face X gave on the goniometer two indifferent images (X1, X:), neither of which could be preferred to the other i the measured angle leads to the indices (775) and (832) if the faces are below z, or to (11. I . I ) and (14.I.I) if they are below r. All four faces have been found by Des Cloizeaux on crystals from Traversella. Angle to m. Des Observed. Calculated. Miller. Bravais. Cloizeaux.


Through experimental study of an array of coupled photonic crystal cavities, we find that the intercavity coupling is significantly larger than the fabrication-induced disorder, a necessary condition for the generation of strongly correlated photons.


Recent radio-frequency resonance-based hightemperature sensors have enable the next generation of passive wireless sensing for harsh environments, such as inside of jet engines. A novel manufacturing technique for an evanescentmode-resonator-based and antenna-integrated wireless passive pressure sensor is proposed therein. This technique employs a planar PCB manufacturing tool to laser etch a 3-D structure on an alumina substrate. A laser machining study is conducted to find etch consistency and fine-tune laser etching parameters. The wireless passive pressure sensor is tested through various mechanical and thermal loads to measure its performance. The sensor is proven to work in the range of $25^{\circ}\mathrm{C} -1700^{\circ}\mathrm{C}$, sensing pressures of 0 psi to 163 psi with resonances within the frequency range of 6.33 GHz--6.7 GHz.


Creativity and environmental care in wetlands have received wide attention from the government and researchers in various countries, especially in the industrial era of 4.0. However, both competencies are less familiar in physics learning. Therefore, this study aims to analyze the effectiveness of Autonomy-Based Creative Learning (ABCL) in improving prospective physics teachers' creativity and caring attitude in wetland environments. This research includes development research using the ADDIE model. The implementation test was conducted on 59 physics education students in South Kalimantan (Indonesia), which were divided into three groups. Before and after learning, prospective physics teachers take a creativity test in designing ABCL, then fill out environmental care questionnaires to determine their attitude on preserving the environment's energy-saving behaviour, managing waste, loving the environment program, and health protocols. The results show increased students' creativity and caring attitude in the wetland environment. N-gain creativity in the medium criteria, while n-gain care for the environment in the standard serial. This creativity is because students initially have a good understanding of environmental care. Thus, this learning is effectively used to equip the creativity and concern of prospective physics teachers in the wetland environment.


In plant biotechnology, the pilot scale step plays a key role in the scaling-up strategy and it stimulates important research programmes, involving novel approaches. Cloning of oil palm (Elaeis guineensis Jacq) is performed by somatic embryogenesis on calli of leaf origin. The transfer of technology from the research laboratory to the pilot production unit was initiated in 1982, and 5 pilot units have been opened. Because of very high production costs, the selling price of clonal plantlets could not be lowered to less than 7 times the price of selected seeds (3 to 5 US$). Furthermore, evaluation in the field has revealed the occurrence of a small percentage (ca 5%) of variant palms which show an abnormal flower development. New methods of automation and scale-up such as embryogenic suspensions are currently developed. Integrated molecular approaches are under way for the study of somaclonal variation. Methylation of genomic DNA is intensively studied, at both genome-wide and sequence-specific levels. Following the example of oil palm micropropagation, a non-linear model is proposed for the transfer of innovation from the original idea to the final adoption by the end-user. (Resume d'auteur)


Carbonate rocks are widespread along South piedmont of Tianshan, northwest Tarim Basin, where is dry-warm temperate continental climate. It is proved by corrosion tests in field with slice that the corrosion rate of limestone and dolomite is 0.281~0.404 mm/ka there. Observed under microscope, fissures formed by corrosion is 0.05~0.2 mm wide and pores formed in the corrosion test is 0.1~0.25 mm in diameter, which shows the important role of infiltrated rainwater on the formation of fissures and pores under continental dry climate conditions.


Business models have been a concept widely discussed over the last 20 years. The increasing availability of data and the growing capability to exploit them with analytics has sparked a new set of discussions, though: it is claimed that data and analytics bring to bear entirely new "data-based" or "data-driven" business models. However, there is neither a common understanding of these business models nor of the ways existing business models are transformed into those. This paper aims to create a coherent framework and common understanding of the infusion of business models by data and analytics. Contrasting popular views, our conceptual analysis reveals that there are no data-driven business models per se, instead, the utilization of data and analytics opens a "continuum" of transformation options for business models. We identify five distinct patterns in which the use of data may alter the business model, illustrate them with representative case studies and evaluate the patterns analyzing a sample of 115 industry business models. This paper will contribute to the fundamental understanding of how the use of data and the application of analytics may trigger business model innovation. The identified patterns will provide guidance to practitioners on how to utilize (big) data and analytics, in particular to draw attention to those that still seem underutilized for innovation. The developed pattern concept will also open up a broad agenda for future research.


The problem of calculating the mass distribution of meteorites and their influx rate can be resolved into three sections; (a) the flux of meteorites hitting the surface of the Earth must be calculated (b) the mass distribution of these meteorites must be assessed, care being taken to include the effect of fragmentation in the atmosphere and (c) atmospheric ablation, which is a function of mass, velocity, composition and zenith angle must be taken into account. The final result will give the meteoritic influx to the Earth's upper atmosphere and its mass distribution. Brown (i960) estimated that the observed meteorite fall rate was 0.32 falls y~1(l06 km2)"1. By considering specific high population areas of the Earth,Brown (1961) revised this rate upwards to 1.09 falls y"~1(l06 km2)"1. Millard (1963) in a detailed study of recovery efficiency raised this figure to 15 falls y"1(10° km2)"1. Both authors assumed that the actual meteorite fall rate was not dependent on the season. To compensate for the fact that the observed rate peaks around June and minimises around December they increased the values given above by ^Cffo. Both authors assumed that the fall rate was independent of time of day. To compensate for the fact that the observed rate peaks at 1500 h and minimises at 0300 h they increased the above values by a further factor of 2. A more reasonable assumption, that the meteorite fall rate follows the meteoroid influx rate would change the latter factor to 4« We are left with;


In Mexico, in the first half of the 19th century, the aspiration to create a different music, independent of the one that had been cultivated in previous centuries, still fails to propose or implement a new musical aesthetic that erases the traces of the European, but rather, stagnates in a parenthesis with hardly any original creations of its own, composers and performers import foreign works or take inspiration from existing styles and works, resulting in easy, superficial scores, in demand for the consumption of a bourgeois public that will impose a trivial taste, destined only to the learning of an instrument or to simple social entertainment, as can be seen in the compositions of the so-called "salon music". It wasn't until the last decades of the 19th century that a Mexican musical idiosyncrasy emerged, expressed in the work, of greater quality and merit, of outstanding national masters. In this process, Zacatecas was not left out.


One to 42-d-old (432) female broilers were fed different levels of inorganic selenium (ISe) and organic selenium (OSe), according to the following treatments: (1) 0.3 mg ISe; (2) 0.3 mg ISe + 0.2 mg OSe; (3) 0.5 mg ISe and (4) 0.3 mg OSe/ kg of feed. All birds were vaccinated against infectious bursal disease (IBD) at 19d of age and three birds/replicate (R) were inoculated with sheep red blood cells (SRBC) at 32d. Three other birds/R received Freund's adjuvant at 37d and avian tuberculin (AT) in the wattle at 47d of age. All birds were submitted to heat stress after 21d. Performance parameters, bursa and spleen weights, lymphocyte bursa depletion, antibody (Ab) production against IBD and SRBC, hematocrit, leukocytes, heterophil/lymphocyte ratio (H/L), and cellular reaction to AT were evaluated. The contrast analysis showed that OSe has improved feed intake (FI) between day 1 and 42 (p<0.10). Birds fed ISe presented worse H/L ratio (p<0.10), but higher Ab titers against IBD (p<0.04) and SRBC (p<0.05) than birds fed OSe, but OSe supplemented birds showed lower lymphocyte depletion scores in the bursa. The higher FI promoted by OSe may be beneficial when rearing broilers in hot weather. The use of ISe induced higher humoral immune response.


The adsorption system of toxic Congo red (CR) industrial dye and red dragon fruit peel (RDFP), a low-cost natural adsorbent reached equilibrium within half an hour. The adsorbent shows high stability and is reasonably resilient to changes in pH while exhibiting strong adsorption characteristics toward CR in solutions of varying ionic strength. The isotherm model among Langmuir, Freundlich, Temkin, Redlich–Peterson and Sips evaluated based on R2, five error functions together with Akaike information criterion indicates that the Sips model is the best fit with the maximum adsorption capacity (qmax) of 71.74 mg g–1, even though the nonlinear regression suggests that the Redlich–Peterson model followed by the Sips model be more suitable to describe the adsorption process. Moreover, there is no statistical difference between linear and nonlinear regression methods, implying that the Sips model is the most appropriate to describe the adsorption system under investigation. Kinetics of interaction of CR and RDFP can be best described by the pseudo-secondorder model with the rate constant of 3.82 g mmol–1 min–1. When compared to many reported adsorbents, RDFP exhibits much higher qmax. All the above results indicate that RDFP has the potential in its application as a good candidate for the removal of CR dye in wastewater treatment.


In evaluating the impact of audio communication on student engagement and learning during online lectures, we observed a phenomenon we call bimodal conversation. While watching lectures, students were given both an audio and a text channel to communicate within their study groups, and it was found that students could engage in coherent conversations using both modes simultaneously. We present an analysis of bimodal conversations from the point of view of conversation analysis, which examines the allocation of conversational turns, and discourse analysis, which examines the context and interpretation of each utterance. Mode selection and mode switching are seen to impact conversations at both these levels, yet students are able to intuitively negotiate both modes simultaneously with few problems. The combination of audio and text modes in the context of online lectures proves to have advantages over either mode taken independently, as students can use the text channel to avoid interference with the lecture audio, but also reap the benefits of real-time audio communication.


A man was hospitalized with bacteremic Achromobacter xylosoxidans type IIIa pneumonia. The authors are aware of no previously reported similar infections caused by this bacterium. A clinical cure was achieved with a combination of carbenicillin and kanamycin therapy. Microtiter susceptibility testing revealed that carbenicillin was the antibiotic to which A. xylosoxidans IIIa was most sensitive (minimal inhibitory concentration, 1.6 microgram/ml) and that synergy between carbenicillin and kanamycin existed. During the patient's hospitalization, deficiency of IgM (21 mg/dl) was found. Specific serum activity against A. xylosoxidans IIIa was detected by the agglutination method. Specific anti-A. xylosoxidans IIIa IgG, but not IgM, was detected by indirect immunofluorescence. It appears that a defect in immunologic recognition of A. xylosoxidans IIIa as an invasive bacterium, a defect in synthesis of specific IgM, or both, contributed to this patient's infection.


Shell-model calculations are performed on the normal parity states of $0p$-shell nuclei with $A=6\ensuremath{-}14$. The Hamiltonian is diagonalized in the full $0p$ basis, and the effective two-body interaction is computed from the Sussex relative harmonic-oscillator matrix elements. The second-order corrections to the two-body matrix elements are calculated for all intermediate states up to $2\ensuremath{\hbar}\ensuremath{\omega}$ excitation energy. The harmonic-oscillator size parameter is taken to be constant at 1.7 fm for all nuclei, and the ${p}_{\frac{3}{2}}\ensuremath{-}{p}_{\frac{1}{2}}$ single-particle energy splitting is determined for each mass number by a least-squares rms fitting to the experimental spectrum. Static and dynamic properties of the energy levels are calculated and found to be usually in good agreement with experiment.


The beginning of the bloom of Chlorobium phaeobacteroides in Lake Kinneret is accompanied by the occurrence of cells of Thiocapsa roseopersicina, which subsequently disappear. It was found that Thiocapsa requires relatively high light intensities (50–100 μE∙m−2∙s−1) for growth which proved to be higher than that for Chlorobium. Acetate played an important role in the growth of Thiocapsa only when the organisms were exposed to light intensities which were not optimal for photosynthesis. Optimum total sulfide concentrations for growth of Thiocapsa were found to be in the range of 1–3 mM. Considering the differential uptake of the reduced sulfur components H2S and HS−, a preference for HS− is suggested. It seems further likely that H2S inhibits growth at concentrations above 1 mM, independent of the pH. Compared with Chlorobium, favourable conditions for Thiocapsa at the beginning of the bloom period are due to low in situ concentrations of H2S, which prevent rapid development of Chlorobium.


Compared with copper cables, aluminum cables have certain advantages in engineering costs and transportation costs, but have installation difficulties in the application process. However, limited by the manufacturing process, installation technology, and operating conditions, the intermediate joint of the aluminum cable is prone to failures such as insulation deterioration caused by abnormal temperature. The temperature of the core of the conductor in a steady state in the cable joint is the most direct and effective physical quantity, which can reflect the operating state. So modeling and analysis of the aluminum cable joint, as well as the study of its internal temperature change mechanism and influencing factors, are to improve the process and installation level of the aluminum cable joint and to develop the basis of the corresponding temperature monitoring system. In this paper, the thermal conduction mechanism of aluminum cable joints in a steady state is analyzed by using the thermal circuit theory. Then, the thermal circuit model of aluminum cable joints in a steady state based on the equivalent thermal circuit model and its parameter calculation method are proposed. By building an experimental platform, the validation experiment finally proved the accuracy of the method proposed in this paper.


We report detailed studies of the photoluminescence (PL) properties of CdSe quantum dots (QDs) grown on ZnSe and Zn0.97Be0.03Se by molecular-beam epitaxy. We performed steady-state and time-resolved PL measurements and observed that nonradiative processes dominate at room temperature (RT) in the CdSe/Zn0.97Be0.03Se QD structures while these nonradiative processes do not dominate in the CdSe/ZnSe QD structures up to RT. We developed a method to estimate the capped CdSe/Zn0.97Be0.03Se QD size and composition, based on PL and photoluminescence excitation as well as Raman scattering spectroscopy measurements. Assuming spherical QDs, we estimate the QD radii to be in the range of 2.5 nm to 4.0 nm with the Cd concentration in the range of 47%–54%. This size is smaller than the exciton Bohr radius, suggesting a nearly zero-dimensional character. We also performed contactless electroreflectance measurements on the CdSe/ZnSe QDs, and observed the transitions due to the QDs and the wetting layer. In this case, assu...


A study was conducted in Cotton Institute,Xinjiang Academy of Agricultural and Reclamation Science in 2011.Taking three main-planting early maturing upland cotton Xinluzao 33(patternⅠ),Xinluzao 36(patternⅡ)and Xinluzao 42(patternⅠ-Ⅱ)as materials,in planting density of the200 000plants per hectare,plant traits were talked about.The results showed that there were significantly differences on plant patterns of early maturing upland cotton which displayed vital genetic diversity,and varieties of patternⅠ-Ⅱ had goodly yield potential.Among 23phenotypic traits,more than 10% variation coefficient was detected in 6traits,including 5plant pattern traits,named leafs bearing stem,plant height,sympodial branch number,monopodial branch number and monopodial branch length,and 1yield trait named Bolls bearing monopodial branch.Twelve traits were detected difference at 0.05significant level,including maturity,plant patterns,yields and quality,accounting for 52.2%.Within 8traits showed difference at 0.01significant level,including 3plant typic traits namely leafs bearing stem,plant height,and sympodial branch number,2yield-related traits namely mass per boll,100-seed weight and 3quality traits namely length uniformity,fiber strength,micronaire value.The consistently changes of variation coefficient and Fof the three varieties was mainly on plant patterns,while yields and quality had also a significant difference on the Fvalue.


Dental implant failure started with a resorption on alveolar crest. Resorption occurred if the stress is greater than the strength threshold (ultimate strength). Bones carrying mechanical loads adapt their strength to the load applied on it by bone modelling or remodelling; by apposition or destruction depends on internal stress level distributed on the bones. This research was conducted using FEM on a CBCT image of model which were implanted and converted into computerized 3D finite element digital model. The model was given material properties, fixed support, and being simulated on occlusal loads of 87 N and friction loads of 29 N for 0,7 seconds.Maximum princip al loads on alveolar bone of implant model was 41 Mpa and still below the ultimate strength (69 MPa). Based on the stress level above, it may be concluded that alveolar bone on implant model has good resistance towards resorption.


Since atmospheric potential oxygen (APO=O 2+1.1xCO2) mainly reflects the air-sea gas exchange of O 2 and CO2 by definition, the spatio-temporal variations in APO are expected to constrain the ocean biogeochemical process and dynamics. Here we examine the relationship between temporal variations in APO trend observed at Cape Ochi-ishi (COI; 43.2 N, 145.5E) and the Pacific Decadal Oscillation (PDO) index to investigate the causes for the inter-annual variations in the APO trend. The PDO is a long-term Pacific climate variability, having two extreme phases which is classified by basin-scale patterns of the sea surface temperature (SST) anomaly. When the SST anomalies are cool in the northern North Pacific and warm in the tropical Pacific, the PDO index has positive value. And the opposite pattern of the SST anomalies correspond to the negative PDO index. The cool SST enhances the ocean vertical ventilation which brings deeper waters with depleted O 2 to the surface, causing the O2 ingassing. The cool SST also enhances the ingassing flux by increasing gas solubility. To the contrary, the enhanced ocean vertical ventilation brings the subsurface nutrients to the surface, enhancing the O 2 outgassing through the increase in the ocean primary production. Thus, the correlation analysis between the changing rate of the APO trend (dAPO/dt) at COI and the PDO index would allow us to investigate how the SST anomaly in the northern North Pacific affect the air-sea gas exchanges. Unfortunately, there is no significant correlation between dAPO/dt and the POD index. However, when dAPO/dt and the PDO index are decomposed into the middle (0.3 <f<0.6 cycle/yr) and low (f <0.3 cycle/yr) frequency domains by using a digital filtering technique, the scatter plots of the middle-term and long-term variations show significant negative and positive correlations, respectively. These results might suggest that the ventilation/thermal effect is dominant for the middle-term SST variation while the biotic effect exceeds it for the long-term SST variation.


Coarse-grained molecular dynamics simulations of stacks of two-dimensional platelets immersed in a polymer melt were performed to investigate aspects of the polymer matrix that promote the formation of intercalated or exfoliated nanocomposite structures. Such factors include temperature, copolymer architecture, and blend composition. Increasing the polymer-sheet attractive interaction led to binding of the sheets, where individual beads simultaneously attract two neighboring sheets, thus kinetically blocking intercalation by occupying the perimeter of the affected gallery. Polymers with a small polymer-sheet attraction, but having a strongly attractive chain end (end-functionalized polymers) minimized the bonding of adjacent sheets. These systems exhibited some sheet sliding because a majority of the confined polymer beads only interacted weakly with adjacent sheets; however, the number density of intercalated polymer was low. Mixtures of end-functionalized and nonfunctionalized polymers, however, yielded better intercalation efficiency. For the mixed system, the reduced number of highly attractive beads provided sufficient interaction for intercalation to occur, enabling greater intercalation rates, less sheet-bridging, and incorporation of the nonfunctionalized polymers into the galleries. © 2003 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 3272–3284, 2003


mences a course of fifty lectures, delivered, we suppose, to his class in Yienna; but whether this be so or not, it is the first sentence we find in the introductory chapter to what may, with complete propriety, be called his great work on surgical pathology and therapeutics; if permitted, we should be disposed to venture something like a paraphrase of the above, and say, The study of medicine, which you begin with this lecture, is now, in most countries, justly regarded as a necessity for the practising surgeon. In point of fact, the division between medicine and surgery


Background: According to the report of Thailand-Israel cooperation on the placement of workers, an incidence of unclear etiology sudden unexpected death (SUD) in Thai migrant workers in Israel betw...


A special correcting winding for the l=2 torsatron toroidal magnetic system with non-standard internal split-type helical coils and with the coils of an additional toroidal magnetic field is considered. The numerical calculations have shown that the winding action upon the initial magnetic surface configuration leads mainly to a displacement of the magnetic surface configuration along the straight z axis of the torus. PACS: 52.55.Hc


The invention provides an artificial propagation promoting method of thelephora ganbajun zangwild and a nursing method thereof in mountain forests for producing wild thelephora ganbajun zangwild, comprising the steps of selecting a proper soil layer depth and a slop; adopting measures such as setting up a greenhouse, and the like, in the growth season of the thelephora ganbajun zangwild to propagate the thelephora ganbajun zangwild by means of mountain closure; adjusting the depth of covering materials; classifying canopy density; using marsh thistle-cleaning liquid; and carrying out steps ofnursing, saving seedlings and promoting propagation such as harvesting, and the like, by means of cutting. The method has a remarkable propagation promoting effect to the wild thelephora ganbajun zangwild, can increase the yield of the wild thelephora ganbajun zangwild, and can improve quality.


Paleoclimate evidence suggests that tropical volcanic eruptions could increase the likelihood of El Niño occurrence. Previous numerical model studies with zonally uniform volcanic aerosol forcing suggested the roles of land cooling‐induced monsoon suppression and ocean cooling‐induced air‐sea interaction in triggering an El Niño following the eruption. Here, we perform targeted sensitivity experiments by confining aerosol forcing over land or ocean only in the fully coupled Community Earth System Model to assess relative roles of these land and ocean cooling. Our results indicate that volcanic aerosol over land, especially over the large landmass of tropical Africa, is more effective in exciting an El Niño than over ocean. The suppressed African monsoon excites Kelvin‐wave westerly wind anomalies over the tropical central Pacific, triggering an El Niño through the Bjerknes feedback. Under the uniform ocean aerosol forcing, the Indian Ocean's fast dipole response induces a slow western Pacific El Niño‐like cooling in the second year.


Determination of disease related biological processes and the estimation of molecular interactions related to these processes are important to understand the underlying mechanism of diseases. In our study we infer gene co-expression networks of breast and colon cancer using miRNA-target gene interactions. Popular information theory based gene network inference algorithms are utilized to infer gene co-expression networks. Literature data, which is used as validation data in overlap analysis, is used to measure the performances of gene network inference algorithms. According to the results, the precision values of gene co-expression networks of two cancers are close to each other. Our study also states that the relevance calculation methods of gene-gene interactions at the first step of gene network inference algorithms don't change the performance results of gene co-expression networks.


Globalization, outsourcing, and insourcing are identified not as objects of demonization but as phenoma that define twenty-first–century reality and economic relationships among states.


Poly(ADP-ribosy)lation (PARylation), which is mediated by poly(ADP-ribose) polymerases (PARPs), catalyzes the transfer of ADP-ribose from NAD+ molecules to acceptor proteins, regulates diverse cellular processes. Since PARP1 gene-deficient mice revealed an increase in urine volume, we aimed to examine the role of PARP1, the most abundant type of protein in the PARPs family, in the vasopressin-mediated AQP2 regulation.

 1) Immunoblotting for PARP1 in mpkCCDc14 cells; 2) Pulldown assay of biotin-conjugated NAD+ and immunoprecipitation (IP) assay using poly(ADP-ribose) (PAR) antibody; 3) qRT-PCR and immunoblotting for AQP2; and 4) Bioinformatics for elucidating PARP1-interacting proteins in kidney collecting duct (CD) cells.

 Immunoblots showed that dDAVP treatment (10−9 M, 2 h, 6 h, 24 h, and 48 h) induced the cleavage of PARP1 (both 89 kDa and 25 kDa) in mpkCCDc14 cells. dDAVP treatment (10−9 M, 24 h) also increased the abundance of total PARylated proteins in biotin-NAD+ pulldown and IP assay of PAR in mpkCCDc14 cells. On the other hand, siRNA-mediated PARP1 knockdown significantly attenuated the dDAVP-induced mRNA and protein abundance, suggesting a role of PARP1 in AQP2 regulation. PARP1 cleavage induced by dDAVP was not changed under PARP1 knockdown, indicating that PARP1 cleavage is unlikely to be involved in AQP2 regulation. In contrast to PARP1 knockdown, PARP1 inhibitor (PJ34) did not reduce the dDAVP-induced AQP2 abundance, despite the significant decrease in the PARylation. The results suggest that dDAVP-regulated AQP2 expression is associated with PARP1 protein per se, but not with PARP1-mediated PARylation. Bioinformatics study revealed that 408 proteins interact with PARP1 in the kidney CD cells. Among them, 49 proteins were mapped on the vasopressin V2 receptor (V2R) signaling pathway. In particular, β-catenin, which is phosphorylated (S552) by dDAVP, was identified as the PARP1-interacting protein mapped on the V2R signaling. Immunoblotting demonstrated that siRNA-mediated knockdown of PARP1 was associated with decreased dDAVP-induced phosphorylation of β-catenin at S552 in mpkCCDc14 cells.

 PARP1 is likely to play a role in vasopressin-mediated AQP2 regulation via the protein interaction with β-catenin rather than PARylation of proteins and/or PARP1 cleavage in the kidney CD cells.


Quest for "Green Energy" has accelerated the exploration activities around the world. Unconventional resources are treated as potential energy source of the century, gas hydrate having a large amount of methane trapped in form of hydrates are widely available in Arctic region and Oceanic sediments. Efforts are required to understand the potential of these unconventional resource and ways of exploiting it in an economical way and with limited footprint. Makogon (1981), showed the capability of chemical enhancers by increase in gas production at the Messoyakha field. Sloan (1992) has also suggested the use of enhancers (inhibitors) in gas production. Our work will deal with series of experiments to determine the effect of polymer (Polyethylene Glycol, PEG) at varying molecular weight and constant mass fraction to study the effect of inhibition on gas hydrate. Through this it has been observed that the lower molecular weight of PEG (Polyethylene Glycol) will show larger inhibition than PEG of higher molecular weight (PEG 200 > PEG 400 > PEG 600). Also that polymer flooding into hydrate reservoir increases the decomposition rate over the pressure drive mechanism.


Northern Arizona is home to the largest contiguous ponderosa pine forest in North America - spanning the Apache-Sitgreaves, Coconino, Kaibab, and Tonto national forests. This vast forest is part of a dry ecosystem that has always been subject to the powerful transformative forces of wildfire, in particular the thinning effects of low-intensity surface fires on pine seedlings and saplings. Suppression of natural fire began on a large scale at the turn of the last century, altering this natural process. As a result, stand density has increased exponentially since the settlement of the state. Recent wildfires, such as the Wallow and the Rodeo-Chediski, are fostered by these overgrown forest conditions.


We aim to understand how patients with Alzheimer's disease (AD) are treated by identifying in a longitudinal fashion the late‐life changes in patients' medical history that precede and follow AD diagnosis.


To study Cd sorption, 16 soil samples of different chemical soil reactions were taken and analyzed for their physical and chemical properties. Adsorption of ethylene glycol monoethyl ether (EGME) and N{sub 2} were determined to establish the specific surface area of the soils. The sorption of Cd was modeled on a per-mass basis using the Langmuir and Freundlich equations as well as per-surface area basis. Traditional sorption isotherms reveal the relation between the amount of Cd sorbed and the Cd concentration in the soil solution only for the soil under study and can therefore not be applied, or can be applied only with restrictions, to other soils. To meet the aim of modeling Cd sorption and mobility for other soils or locations differing greatly in their properties, we attempted to establish a generalizing sorption isotherm for soils of entirely different composition of the solid phase. On the basis of characteristic values the 16 soil samples taken were grouped into three different reaction types (aluminum-hydroxide, silicate, and carbonate-buffer range). The generalizing Cd sorption density isotherms for these different soil groups introduced in the following provide a useful mathematical model for the quantity-intensity relation of Cd in soils that differ greatly inmore » their specific surface area and their composition. 16 refs., 7 figs., 5 tabs.« less


Papillary fibroelastoma (PFEs) is a rare primary benign cardiac tumour which can cause severe embolic complications. We report the case of a 44-year-old with a sessile masse adhering to the aortic valve objectified by a transthoracic echocardiography. This mass was excised surgically and analysed histologically. The diagnosis of papillary fibroelastoma was then confirmed.


Bimetallic nanoparticles have attracted huge attention because they exhibit more efficient characteristics due to the extensive array of chemical and physical properties, synergistic effects, and different mechanisms of action. This review highlights the synthetic routes for synthesis of different bimetallic nanoparticles such as physical, chemical, and biological routes and their use for the removal of pollutants from water such as heavy metals, metalloids, dyes, pharmaceuticals, bacteria's etc. The study shows that bimetallic nanoparticles have been synthesized by various methods and used for the purification and application of water. It also is revealed that the bimetallic nanoparticles are efficient for removal of organic, inorganic, and biological pollutants from water. Furthermore, an up to date review of use of various bimetallic nanoparticles for water treatment is presented in the form of table and the future perspectives and challenges in the field are discussed in detail.


This bachelor thesis provides an analysis of animal characters in both books and it also examines the methods through which the writers depict the connection between the animal characters and their historical counterparts in totalitarian regimes. It also studies the stereotypes according to which both authors portrayed their characters. This thesis sets both books into a historical context and it explains the relation between the events in the book and historical events of the 20th century.


Objective. To study the effect of ketamine on post–stroke pain, a drug challenge test was performed and the effects of a low–dose drip infusion of ketamine were examined in post– stroke pain patients. Methods. In the drug challenge test, 5 mg of ketamine hydrochloride (i.v.) was given every 5 min up to a total of 25 mg in 120 post–stroke pain patients, and the pain reduction rate was assessed using a visual analogue scale (VAS). On the basis of the results of the drug challenge test, the effects of a low–dose ketamine drip infusion (LDKDI) were examined in 55 ketamine– sensitive post–stroke pain patients. For the LDKDI, 20 mg of ketamine hydrochloride added to 100 ml of saline was administered intravenously by 1-hour drip infusion. Results. Fifty-five (45.8%) of 120 patients were evaluated as ketamine–sensitive with regard to their spontaneous pain. All of the 55 ketamine–sensitive patients treated with LDKDI could clearly experience pain reduction. The duration in which patients experienced pain reduction caused by LDKDI ranged from 1 to 6 hours in 27 patients (49%) and experienced in 38 patients (69.0%) up to 24 hours. In contrast, 17 (31%) of 55 patients experienced pain reduction lasting over 24 hours, and 4 (7.2%) of the 55 patients experienced pain reduction lasting about 1 week. In addition, 52 (94.5%) of the 55 patients were satisfied and expressed a desire to continue the LDKDI. Conclusions. About half of the post–stroke pain patients were ketamine–sensitive, and LDKDI is useful for the treatment of post–stroke pain if candidates are selected on the basis of the results of a drug challenge test of ketamine.


Oraldene (Warner) contains 0.1% hexetidine, a saturated pyrimidine derivative. The makers claim that it 'represents an entirely new and scientifically based approach to mouth and throat infections and oral hygiene' and that it is exceptionally suited for oral infections such as gingivitis, stomatitis, aphthous ulcers, dental ulcers and halitosis.


OBJECTIVE To synthesize nefiracetam. METHOD Nefiracetam was synthesized by N acylation of 2,6 dimethylbenzenamine with chloroacetylchloride and N alkylation of 2 pyrrolidone.RESULTS The overall yield was 89.9%. The structure of nefiracetam was confirmed by 1H NMR, 13 C NMR and MS.CONCLUSION This synthetic method is feasible and suitable for industry.


The regulations proposed by the US Environmental Protection Agency to limit the quantity of pollutant gases emitted by aircraft engines allow the exhaust of engines submitted for compliance testing to be sampled by a fixed-multipoint rake. However, the onus is placed on the manufacturer to prove the representativeness of the samples taken in this relatively cheap fashion. To illustrate best possible accuracies, the exhaust of an M45H civil turbofan engine has hen extensively sampled and a computer program has been used to select the optimum configuration of a cruciform rake. The program demanded excellent agreement between the sampling methods and this proved to be the case in actual tests. However, the program also indicates that the errors of a simply designed rake giving area-weighted samples would also be less than 10%. Sampling in the FAA diamond pattern would give rise to a 20% error in CO emissions.Copyright © 1983 by ASME


The Spica and Kala spectrographs located at the rear blanchard of the 1.6 m telescope and the trunnion port of the AEOS 3.67 m telescope, respectively, have been utilized by several DoD and NASA agencies requiring relatively high resolution spectroscopic observations. The sensors are located at the Air Force Maui Optical Station (AMOS), Haleakala, Maui. Three R&D programs utilizing these instruments will be described. The AFRL propulsion directorate's demonstration called the electric propulsion space experiment (ESEX) utilized Spica to evaluate high powered arc-jet thruster firings from the ARGOS satellite. AFRL Det. 15 and Air Force Battlelab sponsored a project called SILC to explore the advantages of applying spectroscopic analysis to help reduce satellite cross- tagging and augment Satellite Object Identification (SOI). Thirdly, the NASA Johnson Space Center Space Debris Program obtained spectroscopic data on Low Earth Orbit (LEO) targets to help determine albedo and material composition of space debris.


Purpose – The purpose of this paper is to contribute to the literature on age and the digital divide by examining the uses of and attitudes toward information and communication technologies (ICTs) by 26 politically senior citizens.Design/methodology/approach – The approach taken involved in‐depth face‐to‐face interviews.Findings – The majority of the respondents are informed and balanced cyber‐enthusiasts who have embraced the opportunities afforded by ICTs to enhance their lives in general, including their political activities.Originality/value – These findings destabilize the dominant image of older people and their attitudes to and experiences of ICTs that appears in most of the literature on age and the digital divide. Those aged 65 and over represent the last cohort, in Western societies at least, for whom age as such is likely to be a decisive factor in their relationship to ICTs. It is therefore vital to get some insight into their views.


1. The influence of adenosine on the release of cyclic adenosine 3',5'‐monophosphate (cyclic AMP) from the heart was examined in twenty‐two anaesthetized intact dogs. The animals were pre‐treated with propranolol and vagotomized. The rate of nucleotide release from the left ventricle was determined as the product of the left ventricular myocardial plasma flow and the coronary veno‐arterial difference in plasma nucleotide concentration. 2. Adenosine was infused into the left ventricle during three successive 15 min periods at rates of 25, 50 and 100 n‐mole/kg. min, respectively. The mean blood pressure in the ascending aorta was prevented from falling by inflating a balloon placed into the thoracic aorta. The measurements were performed before the infusion and at the 10th min of each infusion period. The values given are means +/‐ S.E. 3. During the 45 min infusion of adenosine at increasing rate, the cyclic AMP concentration in arterial plasma increased from 7.0 +/‐ 0.3 to 14.0 +/‐ 0.9 p‐mole/ml. The nucleotide was released from the left ventricle at rates increasing from 48.2 +/‐ 7.1 to 206.5 +/‐ 56.2 p‐mole/100 g. min while the left ventricular myocardial blood flow increased from 127 +/‐ 6 to 399 +/‐ 33 ml./100 g.min. The oxygen consumption of the left ventricle was not modified. 4. When adenosine was infused at a rate of 100 n‐mol/kg.min, the thorax was opened and the apex of the heart and the left atrial appendage were removed for nucleotide assay. The cardiac cyclic AMP concentration did not differ from that observed in control dogs. 5. The results suggest that cyclic AMP is likely to be involved in the membrane and cellular events underlying the relaxant effect of adenosine on the coronary smooth muscle. The lack of change in cardiac cyclic AMP concentration, as determined by whole tissue extractions, is consistent with a study by others showing that, under normoxic conditions, cyclic AMP is released from a small, compartmentalized fraction of the cyclic AMP content of the heart. The elevation of the plasma nucleotide concentration could result from adenosine effects on various cell systems or organs, in addition to the observed release from the heart.


ISIS is the spallation neutron source at the Rutherford Appleton Laboratory in the UK. Operation centres on a 50 Hz proton synchrotron, which accelerates ~3×10 ppp from 70 to 800 MeV, corresponding to beam powers of 0.2 MW. Beam loss limits operational intensity, and a main contributing mechanism is the action of half integer resonance under high space charge. Progress on studies using particle in cell simulations to explore the evolution of envelope motion, associated 2:1 parametric halo, and growth of particles from the outer core is presented. Comparisons are made with relevant theoretical models by studying the simplified 4D coasting beam case.


This study is based on problems that overcome learning difficulties. The research goal is to obtain a picture of the decline of learning kesultian sisw in SMA 1 Padangsidimpuan memalui group counseling services. The method used in this research is True experimental design with pretest-¬Posttest shape control group design. with samples of the experimental class is the first class XI IPS as many as 10 students and the control class is class XI IPS II as many as 10 students so that the total sample of 20 students. Group counseling services are conducted twice meetings and two meetings of information services, namely in the first meeting perform pretest and posttest perform all treatments. Data were analyzed using the Wilcoxon rank test signesd and Kolmogorov Smirnov 2 with the help SPSS version 20.00. From the results of the implementation is done, a significant increase is mainly posttest experiment. The findings in the experimental group and the control group there were significant increases between the posttest and posttest control experiment. On average variable learning difficulties at 143. 6000 (posttest experiment) while the control group 117.4000 (posttest control) looks very significant difference. The conclusion of this study the data processing, shows that the implementation of group counseling services can overcome learning difficulties. It is recommended for teachers to students' learning difficulties is much decreased, and a much better way of learning and implementing the spirit of learning more so that there is no learning difficulties. For further research, is expected to make a research on other learning difficulties in order to assist students in improving ways of learning through other methods. Keywords: Guidance Services Group, Learning Difficulti


According to own characteristic of the civil engineering project risk,this paper has established a model of project risk assessment based on the multi-level fuzzy synthesis judgment.It has analyzed the probability of occurrence for risk factor in engineering project,risk effect consequence as well as uncontrollable degree of the risk and so on in civil engineering project.It has solved the quantitative problem of the risk analysis and appraisal in the civil engineering project.By the example it has explained the feasibility of this kind of model in engineering project risk analysis and appraisal.


Objective To investigate the germ cell apoptosis and MDA concentration following unilateral testicular torsion/detorsion and to explore the possible mechanism which maybe cause the changes of germ cell apoptosis.Methods Thirty-five healthy male rats were randomly divided into sham operation group,pure detorsion group and torsion/detorsion group.Left testes torsion model was established with Turner method in pure detorsion group.The torsion/detorsion group underwent untwisting in torsed testis and they were sacrificed 24h later.All testes underwent histological,germ cell apoptosis and MDA concentration examination.Results Compared with control group,the difference of germ cell apoptosis in reverse side was statistically significant(P0.05)after torsing 2h,but there were no statistically significant in the contralateral side(P0.05).The concentration of MDA increased significantly in both side.With the extension of time,the germ cell apoptosis and the MDA concentration increased significantly in each experimental groups(P0.05).Cnclusion The different damage of germ cell apoptosis comes from the different situation of testicular torsion/detorsion.The damage is related to the ischemia reperfusion injury.The mechanism maybe related to free oxygen radical.


The interactions in polyisoprene/C 16 H 34 and polybutadiene/C 16 H 34 binary liquid mixtures were studied. The Flory-Huggins interaction parameters are calculated. When the effects of concentration fluctuation and free volume on the interaction parameter are taken into account, the interaction parameters are found to be much smaller than the corresponding critical parameters


Udimet 720 is a high strength nickel-base superalloy which in this case was produced via powder metallurgy processing: the billet was in the as-HIP condition. The microstructural response was studied as a function of thermal exposure in the range of 1080°C to 1162OC. Compression specimens were deformed in a matrix of five different temperatures (105O'C - 114O'C) and five strain rates (0.006 min-1 - 3.0 min-l). Resultant grain size, y' precipitate volume fraction and propensity for cracking were evaluated. The grain size coarsened, as expected, with increased temperature for both the thermal exposure and deformed samples. Grain size also coarsened as the deformation strain rate was reduced. Grain boundary cracking (location and density) varied with deformation temperature and strain rate. The resultant grain size correlated well with the volume percent primary Y' present in the microstructure. A relationship between the percent Y' in the structure, and the thermal exposure and deformation conditions is presented along with a discussion of grain boundary pinning. It is suggested that the primary y' and the prior particle boundaries (ppbs) have significant influences on the resultant grain sizes.


Based on the investigation in the field, Drosophila melanogaster Meigen, D. suzukii (Matsumura) and D. hydei (Sturtevant) are the insect pests attacking cherry in Tianshui area, Gansu Province, of which D. melanogaster is a dominant species. The range of host plants, occurrence characters, life cycle and habit, and relationship between development stage and temperature of the major pest are reported. The ant is one of the natural enemies of Drosophila pests in this area.


SARS-COV 2 Is causative agent of COVID 19, just few month ago was foreign to us and now spreading its routes well in India. Starting with one case As of August 25, 2020 in India 3167323 positive cases have been reported. coronavirus is beta form of SARS-CoV-2 belong to family of Coronaviridae. A 44-year-old man, who lives in Kolakata, West Bengal, Working in a travel agency. He came To OPD with complaint of fever, Throat Infection, Multiple joint and muscle pain, Cough. A SARS-CoV-2 Reverse transcriptase polymerase chain reaction (RTPCR) test was positive. He was being treated & Monitored in Home isolation with high dose oral ascorbic acid, hydroxychloroquine, azithromycin and Zinc acetate. This Article aimed to Case Presentation And Treatment Review of Novel COVID 19. [Journal of Current and Advance Medical Research, January 2021;8(1):75-77]


Introduction: Adenoid cystic carcinoma (ACC) of the lacrimal sac is a rare entity characterized by poor prognosis, because of the high rate of local recurrence and metastasis after treatment. Case Report: A 45-year-old male patient was seen at our institution for epiphora, pain, and swelling of the internal angle of the left eye evolving for three months. The clinical examination revealed a fixed mass above the medial canthus of the left eye with blood discharge from the lacrimal punctum at the pressure of the mass. Orbital magnetic resonance imaging (MRI) showed a left lacrimal sac mass. Incisional biopsy disclosed adenoid cystic carcinoma. Conclusion: This is a rare case of lacrimal sac malignant tumor. Adenoid cystic carcinoma can develop in the salivary or lacrimal glands; however, its occurrence in the lacrimal drainage apparatus is extremely rare. Imaging plays a key role in the diagnosis, thanks to computed tomography (CT) scan and magnetic resonance imaging (MRI) which allow a detailed analysis of the local and distant extension, as well as in post-treatment follow-up.


The archaeological research on Tell Qaramel is the result of an agreement between Warsaw University represented by the Polish Center of Archaeology and the Directorate General of Antiquities and Museums in Damascus. 1) The Institute of Archaeology of Warsaw University has also provided financial support. The excavations lasted from March to May 15, 1999.


This discussion acknowledges that interest group - governmental relations deserve further study, but argues that the corporatist literature of the last decade has failed to give useful guidance to the research. One major complaint concerns the hostility in many of the sources to pluralist analysis. As critiques, these attacks have been too shallow to be defended as constructive debate and in dismissing pluralist writings important insights into group-Governmental relations have been neglected.

The article broadly distinguishes two types of pluralism. There is the version which dwells on open competition between groups; there is also, however, a tradition of writing about and discussing closed group-departmental relations and sectorized policy-making. It is clearly this second strain that overlaps considerably with contemporary corporatist interest. It is suggested that it is worth reserving the term corporate pluralism for this model of segmented policymaking. This model is more descriptive than explanatory and is less ordered and systematised than corporatism appears to be in current theoretical use.

It is further argued that in use many writers impute to corporatism little more than corporate pluralism suggests — and that advocates of corporatism now use the term in a less ambitious (an empirical) manner.


OF THE DISCLOSURE A monolithic integrated circuit providing a logic build ing block for logical systems comprising a diode-transistor logical circuit (DTL) having a diodegating input circuit coupled to an emitter-follower stage and controlling an output stage to perform a switching operation in the out put stage for producing high and low logical level output signals in response to high and low level logical signals applied to the diodegating circuit. Current regulation of logical circuit is provided to maintain a constant current gain of a Switching transistor in the output stage during Switching intervals and during operation in a state of Saturation to provide a low impedance, constant current output at the low logical level. Compensation for supply voltage and temperature variations to produce the con stant current gain is provided by current regulation wherein a voltage reference circuit in combination with an interstage coupling resistor regulate the bias current supplied to the switching transistor. The present invention is directed to a logical circuit arrangement and more particularly to an elemental cir cuit which comprises a basic logic building block in the design of logical systems. In the design of logical circuitry for data processing Systems and other logical systems, one of the most im portant achievements is to provide a single circuit ar rangement which is capable of producing a basic circuit operation common to gates, flip-flops, amplifiers and other logical circuits of one or more logical systems. This single circuit arrangement is considered hereinafter as a logic building block for data processing and other logical Systems and the logical circuitry of these systems com prises assembly and interconnection of a very large num ber of these logic building blocks in various arrangements to provide both the individual functions of gates, flip flops, amplifiers, and other logical operations of the System. The provision of a single logical circuit which, when interconnected in various circuit arrangements, provides for all of the logical operations of a system, i.e., a single circuit as a logic building block of a logical system, has become of much greater importance now than before the introduction of fully integrated circuits. There are many Well-known advantages in using fully integrated circuits; however, their use commercially, i.e., competitive with other circuitry, is feasible only if costs thereof can be minimized. The most critical and relatively expensive step in producing fully integrated circuits is involved in the design of a series of sequential photographic masks needed to fabricate, isolate, and interconnect the various component parts on a single silicon substrate. Once these masks are made, semiconductor processes such as solid state diffusion and epitaxial growth permit the simulta neous fabrication of all circuit elements of many logical circuits in approximately the same number of process steps required to manufacture a single transistor. Another important consideration in the use of fully integrated circuits is to avoid the need for inductors and capacitors 10


Challenging bathymetry and soil conditions of future US offshore wind power plants might promote the use of multimember, fixed-bottom structures (or 'jackets') in place of monopiles. Support structures affect costs associated with the balance of system and operation and maintenance. Understanding the link between these costs and the main environmental design drivers is crucial in the quest for a lower levelized cost of energy, and it is the main rationale for this work. Actual cost and engineering data are still scarce; hence, we evaluated a simplified engineering approach to tie key site and turbine parameters (e.g. water depth, wave height, tower-head mass, hub height and generator rating) to the overall support weight. A jacket-and-tower sizing tool, part of the National Renewable Energy Laboratory's system engineering software suite, was utilized to achieve mass-optimized support structures for 81 different configurations. This tool set provides preliminary sizing of all jacket components. Results showed reasonable agreement with the available industry data, and that the jacket mass is mainly driven by water depth, but hub height and tower-head mass become more influential at greater turbine ratings. A larger sensitivity of the structural mass to wave height and target eigenfrequency was observed for the deepest water conditions (>40 m). Thus, techno-economic analyses using this model should be based on accurate estimates of actual metocean conditions and turbine parameters especially for deep waters. The relationships derived from this study will inform National Renewable Energy Laboratory's offshore balance of system cost model, and they will be used to evaluate the impact of changes in technology on offshore wind lower levelized cost of energy. Copyright © 2016 John Wiley & Sons, Ltd.


In this paper, we develop an effective framework to predict in-hospital mortality (IHM) during an intensive care unit (ICU) stay, on the basis of specific medical variables. This work involves both binary mortality predictions and mortality risk estimates, corresponding to Event-1 and Event-2 of the Computing in Cardiology (CinC) Challenge 2012. Our proposed framework contains 1) feature extraction from medical variables by linear interpolation, histogram analysis, and temporal analysis; and 2) mortality classifier learning under Cascaded Adaboost learning model. A released dataset set-a of ICU medical records is used as training set, where cross validation is performed to evaluate our proposed framework. Our framework achieves Event-1 Score1 0.806 and Event-2 Score2 24.00, which outperform those obtained from SAPS-1 score (Score1 0.296 and Score2 68.39) on the same dataset. Over another dataset set-b, our framework obtains Event-1 Score1 0.379 and Event-2 Score2 5331.15.


The widespread availability of digital cameras means that most vets have access to a camera capable of producing high quality clinical images. Photography can be a powerful tool in practice. Anne Fawcett and Gary Norsworthy explore how it can be used to document clinical cases, enhance communication with colleagues and specialists, as well as share information with a wider audience.


When the three royal commissioners, doctors Thomas Bentham, William Fleetwood and Stephen Nevinson, visited Lincoln cathedral in September 1559 their injunctions, which were largely copied from those of the Edwardine visitors in April 1548, marked the permanent establishment of reform within the mother church of the diocese. It is well known that at this time they and other commissioners deprived many of the higher clergy who refused to conform to the new settlement; in the diocese of Lincoln only one of the six archdeacons retained office throughout these troubled years and out of the 54 cathedral prebends either 11 or 12 changed hands. Five canons were displaced to allow the restoration of married clerks and another five or six were deprived. In contrast to this all the cathedral dignitaries and canons residentiary remained, although there is strong reason to suspect their secret hostility to protestant reform. Since Matthew Parker had no wish to recover his deanery, Francis Mallet the faithful chaplain of queen Mary whom she and cardinal Pole just before their deaths had intended to elevate to the see of Salisbury, was permitted to retain his office. Previously he had lived at Court and scarcely visited his church but on 17 August 1560 he protested major residence at Lincoln. His conservatism may be inferred from a sermon which he preached in the cathedral, in 1561 or 1562, wherein he declared in favour of there being seven sacraments. Unfortunately only a month previously the cathedral divinity lecturer, the reformer Thomas Godwin, had preached very vehemently in favour of there being two, and no more than two, sacraments. Thereupon William Todd, who was the only strongly protestant residentiary at the time, had appealed to two local gentry, of whom one was Sir. Francis Ayscough, the brother of the martyred Anne Askew, to raise a complaint against Mallet in the Privy Council. But nothing came of this and Mallet was not dislodged.


We study a new class of finite elements so‐called composite finite elements (CFEs), introduced earlier by Hackbusch and Sauter, Numer. Math., 1997; 75:447‐472, for the approximation of nonlinear parabolic equation in a nonconvex polygonal domain. A two‐scale CFE discretization is used for the space discretizations, where the coarse‐scale grid discretized the domain at an appropriate distance from the boundary and the fine‐scale grid is used to resolve the boundary. A continuous, piecewise linear CFE space is employed for the spatially semidiscrete finite element approximation and the temporal discretizations is based on modified linearized backward Euler scheme. We derive almost optimal‐order convergence in space and optimal order in time for the CFE method in the L∞(L2) norm. Numerical experiment is carried out for an L‐shaped domain to illustrate our theoretical findings.


To a non-negative Borel measure dm(x) on an interval with suitable boundary conditions on the end points, we can associate a generalized differential operator A== -and a strong Markov process X on the support dm(x) dx of dm generated by the operator A. The measure dm is often called a string and the process X a generalized diffusion, also a quasi-diffusion or a gap diffusion, with the speed measure dm(x), cf. [9] for details. Let 0>^>/12>--be the eigenvalues of A= -and let ;?(r, x, y) be dm(x) dx the transition probability density of X with respect to dm(x). It was shown by M.G. Krein [10] and H.P. Mckean-D.B. Ray [12] that


The multichain co‐polymer poly(Tyr,Glu)‐polyAla‐polyLys, designated (T,G)‐A‐L, is normally thought to present only the poly(Tyr,Glu) sequences, designated (T,G), as antigenic determinants. Evidence is presented indicating that at least two different determinant in the (T,G)‐A‐L antigen arc recognized by chicken. Studies in a partly inbred high‐responder chicken strain reveal two major determinant systems: the (T,G) and the A‐ ‐I. in the (T,G)‐A‐ ‐I. antigen. For one serum the antigenic determinant of the A‐ ‐I. backbone is shown to be a poly‐D‐alanine.


: We study the supergravity dual of four-dimensional N = 1 superconformal (cid:12)eld theories arising from wrapping M5-branes on a K(cid:127)ahler two-cycle inside a Calabi-Yau threefold. We derive an e(cid:11)ective three-dimensional theory living on the cobordism between the infrared and ultraviolet Riemann surfaces, describing the renormalization group (cid:13)ows between AdS 7 and AdS 5 as well as between di(cid:11)erent AdS 5 (cid:12)xed points. The realization of this system as an e(cid:11)ective theory is convenient to make connections to known theories, and we show that upon imposing (physical) infrared boundary conditions, the e(cid:11)ective three-dimensional theory further reduces to two-dimensional SU(2) Yang-Mills theory on the Riemann surface.


The social platform based on the short text has gradually become the central platform for the public to express their ideas and opinions. And short-text social platforms such as Micro-blog are popular among the people because of their massive user volume, strong interaction, and real-time convenience. Therefore, the sentiment analysis task of short text platform has become a critical and challenging task since this data has its unique characteristics, such as the number of words limited to 140 words, the topic mode, whether the user is authenticated, etc. The sentiment analysis task in such an environment requires some non-traditional methods. At present, the traditional text sentiment analysis mostly makes sentiment judgment on the content while ignoring the information unique to the user and its platform. This paper proposes a multi-channel convolutional neural network model based on user multi-features, which contains other individual details of a short text. By evaluating on two sets of data sets show that the proposed model is better than the current improved CNN model and LSTM model. It can prove that the short text-specific information is beneficial to the sentiment analysis task and provides a deeper understanding of the text for the classifier.


Cellular automata(CA) have two characteristics make them inherently attractive for application to complex urban systems simulation. The first is that they are substantially spatial; and the second is that they can generate very complex forms by means of very simple rules, namely the local 'uncoordinated' or individualistic actions lead to global patterns with order at higher level. In this paper, the author firstly reviews development of urban CA via selecting five representative instances, analyses their contributions under the temporal social requirements and technological levels and shortcomings, and at last discusses the trend of urban CA in the future.


We describe a new method of using multi-sensory electronic brainstorming to encourage and enable experts to participate in brainstorming with assured attribution of their contributions. This was alpha tested using a customized cloud-based brainstorming tool implemented in Google Hangouts to support synchronous sessions of the I.D.E.A.S. brainstorming method. Participants were trained in using the system in less than ten minutes. Using real-time document sharing combined with visual and auditory inputs, we demonstrated the viability to capture ideas and then the identification of both the "direct" and "causal" ideas to correct participant. Assignment of attribution was done immediately after the brainstorming session via a group discussion with all of the participants based on the time-stamps of the contributions. A screen capture tool was used to document the experience. Managers may use this technique to evaluate the effect of training on the improvement of the benchmarking ability of their employees. The next step is to integrate the I.D.E.A.S. method more fully into an application so that it may be used for beta testing with more subjects, and then improving the causality determination algorithm and other metrics of the system.


Large space-borne programs have resolution requirements more and more important that monolithic telescopes can't achieve in the size limits of the launchers. Thus, Thales Alenia Space wants to design a deployable telescope whom secondary mirror position would be corrected along six degrees of freedom. The principle lies on a hexapod using successively two architectures : a Gough-Stewart platform to achieve the deployment and a "active wrist" concept to correct the final position of the platform supporting the secondary mirror. Second order errors will be corrected by using adaptive optics. Innovation lies in the fact that six tape-spring actuators are used to deploy the hexapod legs. They are based on the principle of carpenter's tape measures. A tape-spring actuator is composed of a thin curved strip coiled on a rotating drum and guided by spiral grooves. The release of the tape-spring strain energies allows the autonomous deployment of the platform. A model of the deployed hexapod has been first performed in order to investigate the structural stiffness in its working configuration. The tape-spring flexibility is modelled by using a condensed finite element model and take into account the deformed and pre-stressed geometry. Validated by an experimental modal analysis, the model is considered as linear and elastic to investigate the platform correction capabilities with the active wrist concept. The influence of the upper joint stiffness is highlighted. The deployment prediction needs to model the tape-spring actuators and to solve the direct dynamic model of a parallel structure. The experimental identification of the tapespring actuator highlights a hysteretic behaviour that can be described by a restoring force model. This model is useful for the elaborating two deployment models which are compared to the experimental results of a gravity compensated deployment. Developed tools allow several analyses. The influence of the micro-vibrations made by the satellite equipments in orbit is observed on the deployment. A sensitivity analysis of the deployment evaluates acceptable tolerances on the tape-spring actuators. The modal evolution of the hexapod during the deployment indicates the swept natural frequency range. The detection of possible singularities during the deployment is carried on with uncertain parameters.


Abstract : This essay identifies opportunities to enhance the United States Army Reserve's (USAR) relevancy in support of the homeland as it pertains to disaster response. It discusses the legal restrictions levied on the Reserve Components prior to the passing of the Fiscal Year 2012 National Defense Authorization Act and the impact the restrictions had on the USAR's ability to respond. The process on how the restrictions were changed is reviewed followed by an examination of the response authorities that the USAR must fall under as part of a tiered federal and military response. The essay identifies challenges in training, equipping and rapidly mobilizing USAR units to conduct an efficient, timely and relevant response. It acknowledges that allowing the Army Reserves to be deployed for disaster response is a strategic benefit to the Nation, the Army, and the Army Reserves but recommends USAR units and Soldiers be trained, equipped and funded to conduct disaster recovery operations instead of emergency response activities. Finally, the essay proposes recommendations that Army Reserve senior leaders can implement to increase the relevance of the Army Reserve in emergency and disaster response.


The importance of factor analysis is to summarize many of the variables to a smaller number of variables known factors. The aim of the research to find out the academic stumble students of the Faculty of Economics and Rural Development, University of Gezira. A sample of 100 students was tested using A questionnaire form consisting of three axes applied to the area of the study. The analytical descriptive method was used and one of the methods of multiple variables (Factor Analysis) was used the Statistical Packages for Social Sciences (SPSS). The results indicate that the main weights affecting the first factor were weak motivation and desire to study and desire to work and work more than the study either affect the second factor is the disintegration of the family because of divorce or otherwise Accordingly, the third factor was affected by the weakness of the mental abilities and the difficulty in absorbing some subjects. The adoption of some faculty member's inappropriate methods in teaching led to a gap between the needs of the student and the content of the subject. Accordingly, the research came out with the recommendations of intensifying the process of guidance in the departments and taking care of academically stumbled students.


Cyberspeak becomes a new media language in net-communication with its own origin and characteristics.Cyberspeak always undergoes the dissimilation of denotation and connotation during the development.This article researches the dissimilation of cyberspeak from the perspective of semiology,based on the theory of Roland Barthes.The results show that dissimilation has three kinds: firstly,denotation unchanges,connotation changes;secondly connotation unchanges,denotation changes;thirdly denotation and connotation both change.At last,the paper upholds that the reason for the dissimilation can be attributed to three aspects: simplicity,vitality and sociality.


He should have been born in the active days of knights-- errant-to have had nothing more serious to do than to ride abroad with a blue ribbon fastened to the point of his lance, and with the spirit to unhorse any one who objected to its color, to to the claims of superiority of the noble lady who had tied it there. Richard Harding Davis, The Princess Aline I. Introduction In mid-1897 as the United States inched toward conflict with Spain over colonial control of Cuba, one sensational event served as a rallying point for Americans intent on war. A young Cuban woman named Evangelina Cisneros1 was charged with conspiracy to assassinate a Spanish official and imprisoned in Havana. The young and brash newspaper editor William Randolph Hearst, however, dumbfounded that such a lovely specimen could be guilty of treasonous crimes, perpetuated a more emotionally-- laden version of the story within the pages of his New York Journal: that Cisneros was held captive because she had chastely refused the advances of a Spanish colonel. Had the Cisneros story been limited to reportage about her imprisonment, whatever its cause, it might have served as little more than a passing example of how newspapers highlighted atrocities against Cuban women before the Spanish-American War. But the story is pertinent today because of how Hearst's Journal created a masterpiece of manufactured news by colliding actuality with fictionality and with familiar literary forms, ultimately drawing upon readers' expectations about one of the most popular genres of the decade-the medievalist romance novel. The story of Cisneros was not a dry presentation of documentary evidence filed within the pages of the Journal. Rather, it was a testimony to her goodness and heroic nature, filled with the melodramatic adventure, unforgettable characters, and forbidding settings of a captivity narrative set in romantic, medievalist discourse. In this grand tale, Hearst's reporters strategically capitalized on the literary vogue of medievalist romances; incorporated those vogues into the news; and rewrote the news as a real romance. They turned the young woman into a cause celebre, portraying her as a virginal heroine transmogrified from the pages of a romance novel and held captive in the fearsome grip of a diabolical Spanish overlord. Hearst's Journal was perhaps the penultimate example of late nineteenth-century "new journalism," an innovative, commercialized, and above all sensationalistic newspaper style first championed in Joseph Pulitzer's New York World.2 Readers at the turn of the century approached the Journal and similar papers confident they would find thrilling stories told by people who spoke from experience-they would encounter the expert, eyewitness accounts of crimes, scandals, accidents, and all things sensational (all mediated, of course, through the reporter's colorful pen). New journalism transformed traditional newspapers, which wrote about the news, into a "journalism that acts," as Hearst himself put it, a journalism that constructed the news and believable-if ultimately fictionalized-stories.3 Hearst encouraged his writers to blend the apparent facts of the news with specific literary vocabularies, creating a meta-fiction that Journal readers consumed voraciously. In the case of Evangelina Cisneros, Hearst created the meta-fiction because he wanted his readers and the government to act, just as his was "the journalism that acts." That is, he wanted to free Cisneros from her Havana jail cell, and he wanted to sell more newspapers as a highly-- desirable by-product of that political action. Hearst recognized that the way to motivate readers-and in turn the government-to act toward the same goal was to make Cisneros' story real to them, something achievable only by turning the facts of the case into a familiar fiction, so that the truth could be stranger (and even better) than fiction. In this article I first survey Hearst's articulations of new journalism. …


Since the fall of the Berlin Wall, the discussions about central role of cities has been accentuated. Especially, from the loss of the city's industrial category due to phenomena of relocation of traditional industries. In this context, a new suburbanization has emerged that give results like the edge cities. Cities have developed new strategies for its aim to keep on occupying central position in the new geography. The main strategies, downtowns and technopolis, are present in this work. The first are expressions that aim to rise as global locations with a high symbolic significance. While the technopolis are ways of technological reindustrialization under the paradigm of a new information economy. Both, however, share the same objective: to attract global flows in a competitive context.


T his manuscript is a classification on Pre-A*-algebra  in sight of it is like a partially ordered set. Using a binary operation in Pre-A*-algebra, an observation is made on Pre A*-Algebra as a partially ordered set with respect to binary operation U and obtained consequent results. It is also grant access to an equivalent condition for a Pre A*-algebra become a Boolean algebra.


Based on a S-R analysis of the summation of overlapping gradients of generalized habit strength, it was predicted that an increase in drive may both lower and raise an empirical generalization gradient depending on the relative response strength of competing tendencies elicited by generalized stimuli. A neutral and a motivated group were presented with a generalized task involving voluntary responses. Each group was subdivided into three groups which differed with respect to percentage of reinforcement of competing responses to generalized stimuli. When the strength of competing responses was negligible, increased motivation raised the gradient, while in other cases the gradient was lowered.


The relationship between Machiavelli and Renaissance humanism remains disputed. While the scholarship of Hans Baron, J. G. A. Pocock, Quentin Skinner, and Maurizio Viroli demonstrates the influence of humanism on Machiavelli, the work of Leo Strauss, Harvey Mansfield, Paul Rahe, Vickie Sullivan, and Catherine Zuckert suggests that Machiavelli's writings also offer an explicit critique of humanism.2 The ambivalent nature of the relationship between Machiavelli and humanism in turn informs the larger debate on the extent of the originality of Machiavelli's political theory. As Quentin Skinner rightly reminds us, Machiavelli's thought is not sui generis but situated within a particular context, and it is only when we have grasped this context that we can properly understand the comparative originality of Machiavelli.3 For Skinner, this context is provided by the humanism of the fourteenth and fifteenth centuries, particularly mirror-for-prince writers such as Patrizi, Pontano, and Castiglione. Skinner argues that Machiavelli and the humanists rebelled against the Augustinian conception of


In order to study the effect of nano-montmorillonite on the electro-osmotic consolidation of bentonite, four groups of electro-osmotic consolidation tests were carried out with different content of nano-montmorillonite (0‰, 1‰, 2‰ and 3‰), and the change rules of current, potential, drainage, water content, pH value and shear strength were analyzed. The results showed that the current, potential and drainage rate decreased with the increase of time. After 48 hours, the current of T2 decreased by 91.23%, which has the lowest decrease rate. Meanwhile, T2 has the largest total discharge and lowest water content. With the distance increasing from anode, the pH value increased, while the shear strength decreased. The research results indicated that nano-montmorillonite has a significant effect on the consolidation of bentonite.


In the framework of R-parity violating supersymmetry, we investigate the time dependent CP asymmetry SKS anomaly of B → KS decay. When the values of the weak phase in the R-parity violating coupling fall into certain parameter spaces (246° < < 263°) we find that this anomaly can be easily explained; at the same time, the branching ratio of B → KS decay can also be in agreement with experimental measurements.


Conference Report for a Conference on Recent Developments in International Criminal Law, organised by the Academia Juris Internationalis Franz von Liszt of the Faculty of Law of Justus-Liebig-University (Giessen, Germany) and the Hesse State Ministry of Justice in the Justice Ministry Building in Wiesbaden, Germany, on 27 April 2004.


Editor—Freeman and Sweeney's study on why general practitioners do not implement evidence seems to share the underlying assumption of so much that is written on this subject—that evidence is clear cut, and the only problem is getting practitioners to put it into practice.1 My perception of evidence, however, is that it is often slippery—at best frequently changing and at worst contradictory and confusing—and that best evidence is often not very good. Part of the problem is therefore deciding exactly what to put into practice.

The findings and interpretation of individual papers, systematic reviews, meta-analyses, and reviews of systematic reviews and meta-analyses are regularly debated in the BMJ. Anticoagulation was one of the clinical areas discussed by the participants in Freeman and Sweeney's study, but stroke prevention in atrial fibrillation is controversial. How many general practitioners who have read the papers on atrial fibrillation in the BMJ over the past couple of years feel confident about the conclusions to be drawn from this evidence as to which of their patients would be best treated with warfarin and which with aspirin? Clinical Evidence helps,2 but can we be sure that its authors are more objective than the combatants in the BMJ ?

The fickleness of evidence is inconvenient but would be easier to live with if it was more widely acknowledged in discussions of implementation.


Prambanan is the biggest Hindu temple in Indonesia, this temple already recognized by UNESCO as one of word heritage. One of the human resources supporting the attraction of the Prambanan Temple is local guide. The purpose of this research is to know influence of service quality local guide towards satisfaction for foreign tourist. This location of this research at Candi Prambanan with 190 respondent, for sample it use purposive sampling method. The data collect by kuisioner which spread to the guest after finish tour with the local guide. Analysis that used in this research is multiple regression with instrument by SPSS 17.0. The results from this research is: 1) Service Quality dimension tangible is influence towards the Satisfaction with point of Sig. 0.037 2) Service Quality dimension empathy not have influence towards the satisfaction with point of Sig. 0.226 3) Service Quality dimension responsiveness individually not have influence towards the Satisfaction with point Sig. 0.290 4) Service Quality dimension reliability have influence towards satisfaction with point Sig 0.02 5)  Service Quality dimension assurance have influence towards satisfaction with point of Sig 0.000 6) Service Quality with all dimension (tangible, empathy, responsiveness, reliability, assurance) have influence towards satisfaction.


This letter gives the comparison of the 3D hybrid implicit–explicit finite‐difference time‐domain (HIE‐FDTD) method with the ADI‐FDTD method through numerical examples. It shows that the HIE‐FDTD method has higher accuracy than the ADI‐FDTD method, especially for larger rate of field variation; the time step size, which has a detrimental effect on the accuracy of ADI‐FDTD, does not affect the accuracy of HIE‐FDTD method. The computation efficiency of the HIE‐FDTD method is higher than ADI‐FDTD method. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 1001–1005, 2007; Published online in Wiley InterScience (www.interscience.wiley.com).DOI 10.1002/mop.22340


The effect of several monoamine oxidase (MAO) inhibitors was investigated on spinal neuronal potentials recorded from an L7 ventral root and evoked by stimulation of an L7 dorsal root. Within 3 to 4 hr after the injection of the MAO inhibitors, pargyline, nialamide, tranylcypromine and α-ethyltryptamine, the monosynaptic spike height was selectively increased whereas the polysynaptic potentials remained unchanged. The increase in the monosynaptic spike height was statistically significant with each compound. The following results indicated that this action was associated with MAO inhibition and the accumulation of 5-hydroxytryptamine (5-HT). Four hours after the injection of pargyline, cord levels of 5-HT and norepinephrine (NE) were increased by 70 and 17%, respectively. Four hours after pretreatment with a MAO inhibitor the actions of 5-hydroxytryptophan (5-HTP) and dihydroxyphenylalanine (dopa) on spinal reflexes were strongly potentiated. Chronic reserpine treatment did not prevent the effects of pargyline or 5-HTP but strongly depressed the response to dopa. The increase of the monosynaptic spike height induced by the MAO inhibitors was immediately antagonized by the 5-HT antagonist methysergide but was not prevented by the NE antagonist phenoxybenzamine.


To evaluate the raw-matgrial quality supplied for combine harvesters, SANTAL-115 (MI), TOET R-300 (M2), and MI?-201 (M3), were subjected to six Test Trials (TT). The variety was Co331, an erect cane, planted in a row spacing of 1.40 m, with a stalk density in the cane row ranging from 4.47 to 16.85 kg/m. The soil was Latosol Red Yellow, sandy phase, and textural natural sandy grouping with a field gradient of less than 2% and moisture soil conditions ranging from 5.09 to 9.85% at the time of trial. From the data obtained f;om TT, the following was determined: Total Extraneous Material Index (TEI%); Top Index (TI%); Leaf and Dry Leaf Index (LI%); Root Index (RI%) Soil Index (§I%); and Non-Selected Material Index (NI%), parameters of Efficacy of Manipulation (EM%), Effective Capacity (EC), "Practical" Effective Capacity (EC'), Frequency of Length of Chopped Canes (F%), were evaluated. Statistical analysis of the values found included the comparisons among means by the method of Tukey. Each index was analyzed separately by verifying harvester effects in Test Trials and harvester x TT interaction. -


A system compatible sensor for the detection of residual moisture in cement screed or concrete was developed as an alternative or addition to the standard of DIN EN 13318 approved methods (calcium carbide and gravimetric methods). Continuous measurements can be made available during the exsiccation which will allow a prediction of surface readiness. Repetitions of measurements are also viable in the same location without vibration or local destruction as well as moisture in varying depths can be assessed simultaneously. Due to its technology of textile fabrication sensors are inexpensive. Thus, several sensors can be placed at preselected locations.


The process of engineering software-intensive systems that comply with their Certification and Accreditation (C&A) requirements involves many critical decision-making activities for the related stakeholders. Considering the exhaustive nature of C&A activities together with the complexity of software-intensive systems, effective decision making relies heavily on the ways to understand and structure the problem domain concepts concerning decision points for interpretation, applicability, scope, evaluation, and impact of the enforced C&A requirements. These decision points are further complicated by natural language specifications of inherently non-functional C&A requirements scattered across multiple regulatory documents with complex interdependencies at different levels of abstractions in the organizational hierarchy, which often result in subjective interpretations and non-standard implementations of the C&A process. To address these issues, we define a systematic methodology using novel techniques from software Requirements Engineering (RE) and knowledge engineering for understanding and structuring the problem domain concepts based on a uniform representation format that promotes common understanding among stakeholders. Specifically, we use advanced ontological engineering techniques driven by theoretical RE foundations to systematically elicit, model, understand, and analyze problem domain concepts concerning significant and difficult decision points throughout the C&A process. We demonstrate the appropriateness of our methodology in creating decision support problem domain ontology using several examples derived from our experiences on automating the Department of Defense Information Technology Security C&A Process (DITSCAP).


On April 20th, 2010, an incident was to take place 49 miles off the Louisiana coast at the Macondo Prospect location in the Gulf of Mexico that would potentially change the future of offshore oil drilling. On that day, 11 men would lose their lives when the 33,000 ton Deepwater Horizon rig, owned by Transocean but leased by BP PLC, exploded. As a result of the explosion, millions of barrels of oil would be released into the Gulf of Mexico, leading to widespread environmental harm and devastation to the shoreline communities. To better examine the underlying reasons for how such an event could take place in 2010, this paper will unfold as follows. First, we provide context to the oil spill by discussing the history of BP, including its transformation into an "environmental" firm in 1995. Second, we explore and analyze the catastrophe through the lens of ethics. Finally, we analyze the disaster through a comparison with the U.S. 2008 financial crisis with a view to identify the root causes of the disaster and the string of ethical failures that have scarred the market economy over the past three or four decades.


The aim of this study was to evaluate the effect of arsenic trioxide as a single agent in acute promyelocytic leukaemia cases for induction, consolidation, and maintenance therapy in a long‐term, 11‐year follow‐up. We studied 60 patients with acute promyelocytic leukaemia. Sixty percent of the patients were aged between 12 and 24 years. Arsenic trioxide was infused at a 0.15 mg/kg daily dose until complete remission was achieved. After 2 weeks of rest, arsenic trioxide was infused daily for 28 days as a consolidation therapy. Then, arsenic infusions were given every 3–4 months for 14 days for 2 years, and the patients were followed until relapse or death. The rates of complete remission, disease‐free survival, overall survival, and drug toxicity were evaluated. The morphologic complete remission was observed in 55 out of the 60 patients. The most common causes of a remission failure were early mortality because of the APL differentiation syndrome and the lack of response to arsenic treatment. The mean follow‐up was 90 months. The primary outcomes for males and females were a mean disease‐free survival of 101 and 97 months, respectively, and a mean overall survival of 103 and 101 months, respectively. From the 55 cases with remission, three patients died (late mortality). Of the 60 patients, 85% are still alive. Arsenic trioxide was generally well tolerated. The long‐term follow‐up of patients with APL, treated with arsenic alone as induction, consolidation, and maintenance therapy, shows high cure rates and excellent outcomes. Copyright © 2015 John Wiley & Sons, Ltd.


An iridium(III) complex exhibiting higher responce towards i-motif DNA over dsDNA and ssDNA was employed for the construction of a TdT activity detection platform. The assay exhibited a linear signal enhancement for TdT in the concentration range of 0 to 8 U mL(-1), and the limit of detection for TdT was 0.25 U mL(-1).


Excerpt To the editor: I read with great interest the review article on chemotherapy-induced emesis (1). Of particular concern, however, was the mention on p. 355 that: "Nabilone has been at least ...


The paper studies the effect of mechanical activation conditions (MA) on the microstructure and phase composition of Ta–Hf–C reaction mixtures and products derived from them by self-propagating high-temperature synthesis (SHS). The mechanical activation of Ta–Hf-C reaction mixtures was carried out in centrifugal planetary mills with different drum rotation speeds. It was found that an increase in the drum rotation speed from 250 to 900 rpm reduced the heterogeneity scale of the reaction charge, reduced the size of coherent scattering regions of tantalum and hafnium by an order of magnitude, and led to an increase in the strain degree of their crystal lattices by 1,5–2,0 times. It was experimentally established that initiation of the SHS reaction in the activated Ta–Hf–C mixture at an initial temperature Т0 Т0 = 800 K only, when the adiabatic combustion temperature reached 3274 K. The single-phase carbide (Ta,Hf)C with a lattice parameter а = 0,44787 nm corresponding to 18,0 at.% of HfC dissolved in TaC, was obtained from reaction mixtures activated under optimal regimes. The content of hafnium oxide in products does not exceed 1 %. The structure of samples is characterized by high porosity (more than 30 %) and a small carbide grain size (less than 10 μm), which made it possible to obtain the (Ta,Hf)C powder by milling the SHS product in a ball mill. Изучено влияние условий механического активирования (МА) на микроструктуру и фазовый состав реакционных смесей Ta–Hf–C и полученных из них методом самораспространяющегося высокотемпературного синтеза (СВС) продуктов. Механическое активирование реакционных смесей Ta–Hf–C проводилось в центробежных планетарных мельницах с различной скоростью вращения барабанов. Выявлено, что повышение скорости вращения барабанов с 250 до 900 об/мин снижает масштаб гетерогенности реакционной шихты, уменьшает размер областей когерентного рассеяния тaнтала и гафния на порядок и приводит к росту степени микродеформации их кристаллических решеток в 1,5–2,0 раза. Экспериментально установлено, что при начальной температуре Т0


This paper addresses several questions about the time series processes followed by dollar exchange rates. The stochastic process for exchange rates implied by structural models and the conditions under which they would be described by random walks are examined. Tests on the univariate time series for dollar exchange rates are undertaken to determine if there is evidence for departures from a random walk. Multivariate tests examine whether longer-run movements in the dollar are linked to those in other economic variables, and whether deviations from these long-run relationships contain information for predicting exchange rate movements.