The species Cymatopleura brunii was named by Paul Petit (Paul Charles Mirbel Petit, 1834–1913, TL-2: 199) but assumed to be first published by Jacques-Joseph Brun (1826–1908) in his article 'Diatomées lacustres, marines ou fossiles, espèces nouvelles ou insuffisamment connues' published in Le Diatomiste (Brun 1895: pl. XIV, fig. 24, reproduced here as Figure 5). Brun's article is composed of only a series of plates accompanied with brief descriptions of most of the specimens illustrated. Although the four plates (XIV–XVII) were issued in sequence as part of the short-lived journal Le Diatomiste, they came with separate covers (the front cover is reproduced here as Figure 12; the end cover is plain). Brun (1895) is often cited as consisting of Pls XIV–XVII and plates XIX–XX. There are, however, just four plates: Pls XIV–XVII. Plate XVIII was never issued (see Le Diatomiste 2: 252) and plates XIX–XXIV are those illustrating Brun (1896), a different article. (A publication history of Le Diatomiste is in preparation). This series of plates included the figure of Cymatopleura brunii with the comment that "Peut etre consideree comme une variété arrondie et tres ridée de la Cym. hybernica W. Sm." (Brun 1895: pl. XIV, fig. 24). Although without any proper written description, it can still be considered a validly published name (see Guiry in Guiry & Guiry 2020). Yet there is an earlier account, which appears to have never been cited since its publication, where Petit provided both a full description and a figure of Cymatopleura brunii (Petit in Lortet 1883: 191, pl. 23, fig. 61, description reproduced here as Figure 11, Petit's figure is reproduced here as Figure 1). This figure appears to differ from that in Brun (1895: pl. XIV, fig. 24, reproduced here as Figure 5).


U.S. student debt has more than tripled since 2004, and at over $1 trillion is now substantially greater than both credit card and auto debt balances. There are substantial potential benefits to be gained from taking out a student loan to fund a college education, including higher earnings and lower unemployment rates for college grads. However, there are significant costs to having student debt: The loans frequently carry relatively high interest rates, delinquency is common and costly (involving potential late fees and collection fees), and the federal government has the power to garnish the wages of individuals with delinquent federally guaranteed student loans (in fact, reported federal recovery rates on defaulted direct student loans exceed 70 percent). The ability of U.S. households to make well-informed decisions regarding higher education and student loan take-up for themselves (or members of their households) depends on the extent to which they accurately perceive the costs and benefits of such choices. To what extent does the American public understand the implications of student loan indebtedness? To shed light on this question, we went out and surveyed U.S. households.


The key to the construction of the quantum box was the placement of a 'small' 2D material on top of a 'larger' layer, creating a potential well within the boundaries of the smaller layer. Credit: FLEET Exciton polariton: a hybrid particle composed of a photon (light) and an exciton (a bound electron-hole pair).


The lifetime of the antisymmetric stretch mode of interstitial oxygen in crystalline Si is measured directly by time-resolved, transient bleaching spectroscopy to be T1 = 229 ± 16 ps at 10 K. The temperature dependence of the li fetime shows that the stretch mode decays into eight vibrational modes of 142 ± 20 cm. The low-temperature width of the FTIR (IR) absorption line due to the stretch mode is 20 times broader than its natural width derived from the li fetime. This homogeneous broadening arises from phase relaxation induced by the coupling between the stretch mode and low-frequency bending modes.


This study is aimed at describing the difficulties and the causes faced by the eleventh grade
students in SMAN 7 Mataram. This study used quantitative and qualitative research methods.
The population of this study involves two classes, with a total number of respondents of 52
students. To collect the data, this study used a test, questionnaire and interview. Based on the
data, all students did not reach the passing standard of 75. Where the results obtained from
the tests given there were 31% of students included in the poor category and the remaining
69% of students included in the very poor category. Most of the respondents get difficulty in
descriptive text about animals and descriptive text about thing. Students are weak in reading
because it is influenced by lack of vocabulary. This is due to the lack of enthusiasm of
students in learning because the learning method used is less varied. In addition, students'
worksheets that used are less attractive and hardto understand for the students.


This paper presents a novel perturbation-based extremum seeking (ES) based on the smooth approximation of the sign of the gradient of unknown plant maps, which will improve the stability and the control performance of ES. The stability and the convergence speed of conventional sinusoidally perturbed gradient-based ES are very sensitive to the curvature of an unknown plant map, which has motivated the development of improved ES schemes that are less sensitive to the curvature such as Newton-like ES schemes. In this paper, an alternative ES scheme is proposed by estimating the sign of the gradient instead of the gradient itself. The ES scheme not only frees us from taking care of the curvature of the unknown map but also is able to minimize the increase of implementation complexity by just incorporating the signum function for the conventional ES scheme. Moreover, the signum function is replaced by its smooth approximation such as the softsign or a sigmoid function in order not only to suppress chattering phenomena but also to be able to adjust the behavior in the vicinity of an extremum point. It is also shown that the local-stability of the proposed ES scheme can be proved under some mild assumptions for the approximation function. The effectiveness of the proposed ES is demonstrated by some simulation examples for a simple process model and for a complex nonlinear biological wastewater treatment process model.


Identification of high-risk severe cases from influenza-like illness (ILI) is crucial for disease surveilance and clinical management. Comorbidity and demography profile may be a good risk estimation. The study utilized Taiwanese National Health Insurance Database, ICD-9, and Marsden-Haug's ILI Codes to measure the effect of systemic classes of comorbidity on four outcomes: ospitalization cost, length of stay (LOS), death, and intensive care unit (ICU) entry.


e20626 Background: Resistance mechanisms to osimertinib have raised growing concerns, but those with acquired RET rearrangement is poorly characterized. Methods: We retrospectively identified advanced, EGFR-mutant NSCLC (non-small-cell lung cancer) patients treated with osimertinib between April 9th, 2015 and November 1st, 2018 at our institute. Clinicopathologic features and clinical outcomes were analyzed. Subsequent genetic profiling was performed at the time of progression by next-generation sequencing (NGS). Overall survival (OS) since 1st line treatment was calculated from first-line treatment start to death or last follow up, and OS post-progression was calculated from osimertinib progression. Median follow-up time was 43.4 months. Results: In the 192 patients treated with osimertinib, 57 had follow-up NGS information after progression, and six harboured acquired RET rearrangement (11%, 6/57). For patients with RET rearrangements when progressed on osimertinib, OS since 1st line treatment (22.9m vs 59.5m, P = 0.021) and OS post-progression (2.1m vs 10.0m, P = 0.031) were significantly shorter compared with non- RET-rearranged cases, whereas no significant difference was found in demographics at the initial lung cancer diagnosis or progression-free survival (PFS) of osimertinib (12.1m vs 5.8m, P = 0.34). Among these six patients, one received best supportive care, two continued to use drugs targeting EGFR but deteriorating soon, three patients tried osimertinib combined with cabozantinib with one benefit from this combination approach. Conclusions: RET rearrangements could exist in EGFR-mutant NSCLC with acquired resistance to osimertinib and linked to inferior survival. Study on the molecular evolution and heterogeneity during treatment course are warranted for further therapeutic strategies. [Table: see text]


In this paper, we focus on top-down discretization methods and propose a new method for supervised discretization based on class-feature correlation by defining a class-feature contingency factor. The proposed method takes into consideration the distribution of all samples to generate an ideal discretization scheme. The method maintains a high interdependence between the target class and the discretized attribute, and avoids overfitting. Empirical evaluation of seven discretization algorithms on UCI real datasets show that the novel algorithm can yield a better discretization scheme that improves the accuracy of decision tree classification. As to the execution time of discretization and the number of generated rules, our approach also achieves promising results.


This article summarizes an investigation of the effects of past high inflation on future performance measures if inflation were to disappear. Computer simulations were used to estimate continuing differences between historical cost and current cost measures and their patterns of convergence over time. Current cost accounting and three combinations of historical cost accounting were applied to an average manufacturer and an average retailer, each company being based on empirical price data and average financial characteristics for its industry. Results for the period of stable prices show that, even for the average retailer, historical cost rates of return can differ from current-cost returns by material amounts (at least 10 percent higher) for more than a decade. The findings suggest a need to reconsider the increasingly popular belief that inflation is no longer high enough to bother with current cost disclosures.


Workflow technology is used to improve the traditional ERP system with an example of workflow-based ERP system and the design- ing process from component construction to the whole workflow-based ERP system is illustrated with a purchasing fund application subsystem in a papermaking enterprise.


Performance of the low-voltage and power-efficient analog-to-digital (A/D) converters, like cyclic and pipeline topologies, can be significantly enhanced by using advanced analog cores. This paper describes a careful switched capacitor (SC) architecture that can be used as a simple low-voltage implementation of the flip-around sample-and-hold (S/H) circuit. The S/H has been simulated in a 0.13µm CMOS technology featuring a signal to noise and distortion ratio (SNDR) of −75dB at 12Ms/s for a 1Vpp output voltage. Theoretical calculations and experimental results are also given to demonstrate its validity.


Purpose – Hospitality organizations, whether large or small, are complex entities requiring managers to work through frontline employees to manage every guest's moment of truth and meet their firms' goals and objectives. This study aims to test propositions that firms whose staffing policies and systems are aligned with their strategic goals and objectives to outperform those firms with poorer organizational alignment.Design/methodology/approach – Data were collected through a survey administered in winter of 2005 to 200 hourly wage employees from each of four matched hotels. Some 479 completed surveys were returned yielding a 59 percent response rate.Findings – Between‐group differences in organizational alignment measures were statistically significant in the directions predicted. Specifically, subjects from the high organizational alignment hotels, on average, reported significantly higher organizational support, employee service commitment and employee satisfaction as compared to low organizational al...


triplicate, of the forms, possibilities, and conditions of self-referential narrative in each of the works that are the subject of this study. by analyzing the function and effect of such devices as repetition, mirroring, and framing, buhr has succeeded admirably in demonstrating the self-reflexive nature of the various love stories. the author concludes that through their self-referentiality, the courtly narratives observe and describe themselves as love tales, respectively love romances. He has convincingly demonstrated that literary self-referentiality is by no means a phenomenon reserved for modern literature. Marianne Kalinke University of Illinois at Urbana-Champaign


This work presents a computational approach to model efficient terahertz photoconductive antennas. Two configurations have been proposed and optimized using RF module and further verified using wave optics module present in commercially available finite element method solver COMSOL Multiphysics. For this optimized configuration, optical response has been simulated for femtosecond optical pulse excitation. Semiconductor module is then utilized to study electrical response of the 2D THz-PCA. The obtained results support the efficient generation of THz-PCA by observing transient current collected at the terminals of the electrode, addressing the problem of low output power of THz PCA.


This study focuses on the importance in hyperdiverse regions, such as the Amazonian forest, of accelerating and optimising the census of invertebrate communities. We carried out low‐intensity sampling of tropical moth (Lepidoptera) assemblages in disturbed forest fragments in Brazil. We combined DNA barcoding and taxonomists' expertise to produce fast and accurate surveys of local diversity, including the recognition and census of undescribed and endemic species. Integrating expert knowledge of species distributions, we show that despite limited sampling effort, our approach revealed an unexpectedly high number of new and endemic species in severely threatened tropical forest fragments. These results highlight the risk of silent centinelan extinctions and emphasise the urgent need for accelerated invertebrate surveys in high‐endemism and human‐impacted tropical forests.


The purpose of this study was to develop
 a suitable bait formula which can be used as an oral vaccination bait for
 wolves (Canis lupus) against rabies. Due to the current population trend of
 wolfs in Germany an introduction of the zoonosis cannot be ruled out. To
 guarantee a quick reaction in case of a rabies outbreak the bait matrix in
 which the blister will be integrated must be machine producible. The
 development of a suitable bait is necessary to stop or eliminate rabies as
 has performed in foxes. Therefore the present study has relevancy for animal
 welfare and conservation. To determine the taste prevalence of
 wolves different bait combinations were tested in various zoological
 institutions. The very well accepted
 intestinal bait (domestic pig) proved to be the optimal positive control and
 the poorly accepted fish bait (fox bait) served as the negative control in
 this study. As an egg based bait (egg bait) showed no significant difference
 in acceptance to the intestinal bait, this was chosen as a base material. In
 contrast to the intestinal bait the egg bait triggered the necessary chewing
 movements to perforate the vaccine blister which will be integrated in
 future. The absolved experiments confirm that the egg bait is suitable for
 mechanical mass production. Accordingly in this study the egg bait with
 several flavour enhancing substances and was offered to the wolves. During their
 main activity time the wolves discovered the egg-rumen-flour-coated bait more
 significantly often than the egg bait. Thus the egg-rumen-flour-coated bait
 is the bait of choice. Based on the presented and discussed results future
 studies can be aimed at finding a suitable blister. It is recommended that
 the blister is tested by wolves in different institutions. The final step
 would then be to test the reaction of free ranging wolves to the whole bait
 (matrix + blister) in the field.


Death and Bereavement Across Cultures is the second edition of the classic collection of essays first published by the authors in 1997 and remains a pioneering handbook for doctors, nurses, social workers, hospital chaplains, counselors, and volunteers who deal with death and bereavement. The book follows the same structure as the first edition, but with important updates. Many chapters are written by renowned experts in the field such as Paul Rosenblatt on traditional "small scale societies"; Tony Walter on "secularisation"; or indeed the lead editor, Colin Parkes, who was for many years consultant psychiatrist to St. Christopher's Hospice and who coauthored the two introductions and single authored key chapters "Help for the Dying and Bereaved" and "Conclusions II: Attachment and Losses in Cross Cultural Perspective." One touching aspect is that one of the coeditors, Pittu Laungani, who helped plan this revised edition, died before it could be published. The volume is dedicated to him and notes that he "faced the prospect of his own death from a life-threatening disease with dogged determination, curiosity and wry humour. This book is part of his harvest." The book covers the main world religions with emphasis on how secularisation is dramatically changing attitudes toward dying. The extent of secular trends is illustrated by the observation that even in a Christian hospice a nurse would risk dismissal by agreeing to say the Lord's Prayer for a dying patient. Spirituality is the watchword today while religion itself is "uncool." An extremely valuable aspect of the volume is that each chapter includes a bullet point summary of its main points in very accessible form. For example, consider this sample from Colin Parkes's concluding chapter:


Objective Orchastric changes in the mammary glands are vital, especially during lactation. The secretary epithelial cells together with the supporting myoepithelial and stromal cells function cordially to secrete milk. Increase in the number of luminal epithelial cells and a decrease in adipocytes are visible during lactation, whereas the reverse happens in the involution. However, an early involution occurs if the epithelial cells transdifferentiate towards adipocytes during the lactation period. We aimed to inhibit the adipocyte transdifferentiation of luminal cells by restraining the peroxisomal proliferator-activated receptor γ (PPARγ) pathway. Methods Linolenic acid (LA) and thiazolidinediones (TZDs) induced adipogenesis in mammary epithelial cells were conducted in monolayer, mixed culture as well as in transwell plate co-culture with mammary myoepithelial cells. Results Co-culture with myoepithelial cells showed higher adipogenic gene expression in epithelial cells under LA+TZDs treatment. Increase in the expressions of PPARγ, CCAAT/enhancer-binding protein α and vimentin in both mRNA as well as protein levels were observed. Whereas, bisphenol A diglycidyl ether treatment blocked LA+TZDs induced adipogenesis, as it could not show a significant rise in adipose related markers. Although comparative results were found in both mixed culture and monolayer conditions, co-culture technic was found to work better than the others. Conclusion Antagonizing PPARγ pathway in the presence of myoepithelial cells can significantly reduce the adipogenisis in epithelial cells, suggesting therapeutic inhibition of PPARγ can be considered to counter early involution or excessive adipogenesis in mammary epithelium in animals.


This publication is a compilation of original and republished materials from numerous individuals and organizations working on pesticide reform and integrated pest management (IPM)--using alternatives to prevailing chemical-intensive practices. The manual provides comprehensive information on implementing school IPM, including a practical guide to identifying, preventing, and controlling common school pest problems. It is designed for individuals who are responsible for school pest management. It includes information on why schools should adopt IPM programs, how to develop and implement a program, pest management strategies for structural pests, school IPM experts, a model policy and contract, a nonand least-toxic product guide, and fact sheets on the toxicity of commonly used pesticides in schools. (EV) Reproductions supplied by EDRS are the best that can be made from the original document. U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. Minor changes have been made to improve reproduction quality. Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. Building Blocks for School IPM A Least-toxic Pest Management Manual PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY


Theoretical gamma-ray spectra of molecule hexane have been calculated and compared with the experimental results in both gas (Surko et al, 1997) and liquid (Kerr et al, 1965) phases. The present study reveals that in gas phase not all valence electrons of hexane exhibit the same probability to annihilate a positron. Only the positrophilic electrons in the valence space dominate the gamma-ray spectra, which are in good agreement with the gas phase measurement. When hexane is confined in liquid phase, however, the intermolecular interactions ultimately eliminate the free molecular orientation and selectivity for the positrophilic electrons in the gas phase. As a result, the gamma-ray spectra of hexane become an averaged contribution from all valence electrons, which is again in agreement with liquid phase measurement. The roles of the positrophilic electrons in annihilation process for gas and liquid phases of hexane have been recognized for the first time in the present study.


Endothelin-1 is a potent modulator for vascular tone originally isolated from the culture solution of porcine aortic endothelial cells (Yanagisawa et al. 1988). Recent several reports have suggested that endothelin-isopeptides may be a neuromodulator in the autonomic nervous system. Endothelin-binding sites (Inagaki et al. 1991) and endothelin-like immunoreactivities (Hemsen and Lundberg, 1991; Inagaki et al. 1991) were found in mammalian autonomic ganglia. Endothelin-1 causes not only a slow membrane depolarization followed by a hyperpolarization but also both depression and facilitation of the voltage gated calcium current in mammalian parasympathetic neurons Nishimura et al. 1991a, b). Endothelin-1 reduces evoked releases of norepinephrine from sympathetic nerve terminals (Tabuchi et al. 1989; Wiklund et al. 1989) and acetylcholine from presynaptic nerve terminals in parasympathetic ganglia (Nishimura et al. 1991b). Cloning of complementary DNA for endothelin receptors revealed that these endothelinreceptors belong to the superfamily of the GTP binding (G)-protein-coupled receptors in the nervous system (Arai et al. 1990; Sakurai et al. 1990). However, electro-


The number of international graduate students choosing Malaysia as their destination of study is increasing. These students arrive to Malaysian shores with diverse academic, cultural and linguistic background with the intention of upgrading their academic qualification especially at graduate level.  The students are confronted with a mismatch between the literacy practices in their native country and at graduate level currently. This leads to challenges in adapting to the current academic writing practices at graduate level. Academic writing is a productive skill that is pivotal to ensure academic success. However, students for whom English is a foreign language struggle in writing various sections of academic work at graduate level such as the methodology and discussion sections. This qualitative study focuses on academic writing difficulties faced by the non-native English speaking international graduate students while pursuing their Master's degree at a public university in Malaysia. Focus group interview was used on 70 international graduate students from taught Master programs to elicit qualitative data. The main objective of the focus group interviews was to analyze how these students negotiate academic writing from an emic perspective. Through this approach, the students were able to share their own experiences of struggling with academic writing practices in higher education. The findings indicate that non-native English speaking international graduate students faced difficulties coping with academic writing especially in English as a medium of instruction setting. This study highlights the need of host institutions in providing academic support to improve the most crucial literacy skill that contributes to academic success at graduate level.  DOI: http://doi.org/10.17576/gema-2016-1603-06


This paper studies data of ultraviolet (290–385 nm band) horizontal solar irradiation and global horizontal solar irradiation measured at Valencia (Spain) during the period March 1991 to September 1991. Analysis of error estimations and correlation coefficients show that the 10 minute, hourly, and daily values of ultraviolet (UV) and global irradiation are highly correlated. Improved figures and less dependence on location are achieved by defining a clearness index for the UV 290–385 nm band and relating it to the conventional whole-band clearness index. The novel clearness index obtained from Valencia data is approximately half of the conventional clearness index. Considering solar elevation as an additional parameter, the correlation coefficients increase to values in the 0.94 to 0.96 interval for solar elevations greater than 55°, both for hourly and 10-minute values.


Most children have no homes, says Mr. Hethrington. Child life and home life have been sacrificed to industry. The home has become a dressing room and refreshment center. Old home functions are shifted to the school. Physical education is one of these, so recently in its new place that it needs interpretation.


Centinormalized units (values expressed as a percentage of the upper limit of the reference range) have been proposed as a logical way of reporting enzyme results. We argue that this would not eliminate the need to refer to reference ranges, nor would it confer comparability of results between laboratories. The present confusing situation will be solved only by the adoption of standardized methods of estimation. ( JAMA 1981;245:2431-2432)


This paper studies design methods for material composition and road performance of synchronous gravel sealing,and analyzes performance of synchronous gravel sealing technology by means of testing methods such as pull test,swing value test and permeability test,etc.so as to provide theoretical and practice bases for utilization of synchronous gravel sealing technology.


Xanthomas are grayish-yellow masses composed of lipid-filled foamy histiocytes, extracellular cholesterol, giant cells, and inflammatory cells [1], and are usually caused by cholesterol accumulation in familial hypercholesterolemia or some other diseases and may be the mainstay of the clinical diagnoses of these lipid disorders [2]. Xanthomas usually involve skin and subcutaneous tissue, and sometimes involve tendon and bone deeply [3-5]. Tendinous xanthoma usually involves hand extensor tendons, but may also be found on elbow, patella, and Achilles tendons. Several tendinous xanthomas have been reported and are known to be associated with a clinical finding of hyperlipidemia [2,3]. A few case reports have been issued on xanthomas with a normal lipid profile, most concerned plane xanthoma [5] and others tendinous xanthoma of Achilles tendon [6]. Here, we report a rare case of huge multiple tendinous xanthomas in 정상적인 지질 수치를 보이는 환자의 사지에서 발생한 다발성 거대 건황색종


Background: Transbronchial cryobiopsy (TBCB), a novel way of obtaining a specimen of lung tissue using a flexible cryoprobe, can obtain large lung biopsies without crush artifacts. The freezing time of TBCB was empirically selected from 3 to 7 s in the previous studies. However, no consensus has yet been reached regarding the optimal freezing time used in TBCB. Objectives: The primary endpoint was biopsy size in different freezing times. The secondary endpoints included sample histological quality, diagnostic confidence, and complications in different freezing times. Methods: Patients who were suspected of DPLD requiring histopathological examination for further evaluation were enrolled in this study. Distinct biopsies were obtained by using different freezing times increased from 3 to 6 s sequentially. Samples were reviewed by 2 external expert pathologists. Results: A total of 33 patients were enrolled, and 143 transbronchial cryobiopsies were taken in this trial. An average of 4.33 samples were taken from each patient. The mean biopsy size of different freezing times from 3 to 6 s was 9.10 ± 4.37, 13.23 ± 5.83, 16.26 ± 5.67, and 18.83 ± 7.50 mm2, respectively. A strong correlation between freezing time and biopsy size was observed (r = 0.99, p < 0.01). Statistically significant difference of biopsy size was detected in the freezing time of 3 s versus 4 s (p < 0.01) and 4 s versus 5 s (p = 0.02), but not in the freezing time of 5 s versus 6 s (p = 0.10). Overall bleeding in different freezing times from 3 to 6 s was 53.33%, 67.50%, 89.47%, and 77.14%, respectively. A significantly higher overall bleeding was observed when the freezing time exceeded 4 s (RR = 1.67, p < 0.01). Pneumothorax occurred in 4 cases (12.12%). One lethal case (3.03%) was noted 25 days after TBCB. Lung parenchyma was preserved well in all cryobiopsy samples. Thirty-one (93.94%) patients' histopathological findings were identified as sufficient to establish a CRP diagnosis. There was no statistical difference in diagnostic confidence between different freezing times. Conclusion: A longer freezing time was associated with a larger size of the biopsy sample but a higher risk of bleeding. The optimal transbronchial cryobiopsy freezing time is 3–4 s, which is easily achievable and provides an adequate biopsy size whilst creating a safety threshold from complications.


Fluid inclusions containing chalcopyrite (Cpy) daughter minerals have been recognized in many magmatic/hydrothermal ore deposits and have been used by many workers to estimate the copper concentrations of ore-forming fluids. The authors have developed a graphical technique that facilitates estimation of the concentrations of Cu, Fe and S in individual fluid inclusions. Application of this technique to natural fluid inclusions indicates a wide range in copper concentrations in ore-forming fluids, from a few hundred ppm to a few wt. % copper. This same technique has been applied to synthetic fluid inclusions to estimate the solubilities of metals and sulfur at magmatic/hydrothermal conditions. For example, at 600 C and 3 kbar, this technique gives solubilities of 1,910, 1,680, and 1,890 ppm Cu, Fe and S, respectively, in a 10 wt.% NaCl solution in equilibrium with Cpy. A diagram summarizes the relationship between the size of the Cpy daughter mineral as seen in two dimensions, the volume percent Cpy in the inclusion, and the concentration of copper required to produce a Cpy daughter mineral of that size.


A 2-min leukocyte esterase dip-stick test for pyuria was used to screen 409 consecutive clinical specimens received for culture. The leukocyte esterase dip-stick test proved to be a sensitive and inexpensive means of screening urine specimens for the absence of leukocytes and, by inference, for the absence of significant bacteruria.


The synthetic seismic correlation of conversion S-wave for the interpretation of P-S wave seismic data was researched,and a method of making P-SV shear wave synthetic seismic record was proposed. According to deduction and statistics,pseudo P-S wave sonic log can be gotten by the P-wave sonic plus S-wave sonic,and good pseudo reflection coefficient of P-S wave can be gotten.Then,synthetic P-S seismic record can be made by conventional ways,and a synthetic P-S seismic record with correct time and approximate amplitude can be obtained. The method is characterized by simplicity. The application results of real data proved the validity and the foreground of the method.


A previous analysis of the internal structure of ionizing shocks is extended to slow shocks. The results indicate that the slow ionizing shock behaves like a slow magnetohydrodynamic shock in which all the gas is electrically conductive. Also, the beginning of the slow ionizing shock is similar to that of a slow magnetohydrodynamic sub-shock. (tr-auth)


ABSTRACT This work analyzes selected Protestant college libraries' holdings of gay, lesbian, bisexual, and transgender (GLBT) content in order to measure access to materials for readers, determine the nature of the materials, and identify what resources selectors might use to inform purchases. The study identifies twenty titles and ten libraries for a comparison of the holdings. Ten Lambda Award–winning titles deemed affirming of the relationship between religion and homosexuality and ten titles identified as non–GLBT-affirming in nature are used to make these determinations. This article seeks to expand the body of knowledge available on Protestant college libraries while specifically documenting the presence of GLBT materials in such libraries.


Telecommunications networks evolve towards cloud computing. The vast deployment of heavy processing applications (e.g., AI/ML) in telco has introduced performance constraints. The recent emergence of FPGA-based clouds brings new opportunities for telco services to guarantee a good quality of service and performance. In a telco context as in a cloud context, security is critical. Telecom Operator (TO) privacy and data protection must be ensured in FPGA-based cloud solutions. First, the method used to remotely access the FPGA cloud must be secure. Then, each TO's execution context has to be isolated to protect user privacy and confidentiality. For that, authorizations must be defined and access control policies need to be properly enforced. In this paper, an authentication and tokenized FPGA access delegation scheme adapted from OAuth 2 is described. This solution brings a new token-based approach for FPGA devices and proposes a secure access delegation protocol for the cloudification of 5G networks and beyond. The access token is a lightweight solution to securely share information and enforce access control inside a multi-user FPGA. The proposed solution allows a TO to securely share third party cloud resources with another TO subcontractor. The sharing process involves a Trusted Authority (TA) and works without the approval of the FPGA cloud owner. This mechanism and the associated FPGA environment reinforces the highly sought privacy and confidentiality in FPGA clouds. FPGA resource allocation and reconfiguration is achieved in 503 ms and is 37.8% faster when compared to the literature. Performance results show flexibility and cost efficiency for telco services.


Amyloidosis of the urinary bladder is a rare urological disease having similar clinical symptoms and cystoscopic findings to bladder tumors. Herein, we report a 68-year- old female who was admitted with the chief complaints of painless gross total hematuria with clots and dysu-ria. A series of studies were done to reveal normal findings except for a mass lesion in the blad-der. The cystoscopy revealed a non-papillary tumor at the dome with bleeding. Transurethral re-section of bladder tumor was performed. The final clinicopathological diagnosis was primary amyloidosis of the urinary bladder. So far, this patient is regularly followed at our out-patient clinic with stable condition. The literature is reviewed.(J Urol R.O.C., 9:200-203,1998)


The activity of a range of antibiotics on intracellular Staphylococcus aureus was examined using an in vitro system in which staphylococci survived within bovine neutrophils and extracellular organisms were killed by lysostaphin. Cloxacillin in the presence of lysostaphin caused a reduction in the number of viable intracellular S. aureus but cloxacillin alone failed to reduce such bacteria significantly. The cloxacillin appeared to sensitize the staphylococci to lysis by extracellular traces of lysostaphin following neutrophil disruption. Extracellular staphylococci which remained viable after exposure to cloxacillin in the absence of lysostaphin were subsequently killed more rapidly by neutrophils, but this was not found with bacteria exposed to cloxacillin while inside cells. Vancomycin with lysostaphin produced a similar but smaller sensitization effect but this antibiotic also appeared to increase survival of intracellular staphylococci when compared with controls, possibly by impeding neutrophil bactericidal mechanisms. The only other antibiotic to show significant intracellular killing was rifampicin, and in this case the action was independent of lysostaphin.


Heavy metal pollution is a serious and widely environmental problem due to the persistent and non-biodegradable properties of these contaminants. Sediments serve as the ultimate sink of heavy metals in the marine environment and they play an important role in the transport and storage of potentially hazardous metals. They are introduced into the aquatic system as a result of weathering of soil and rocks, from volcanic eruptions and from a variety of human activities involving mining, dredging, processing and use of metals and/or substances containing metal contaminants. Heavy metals entering natural water become part of the watersediment system and their distribution processes are controlled by a dynamic set of physico‐ chemical interactions and equilibria. The properties of metals in soils and sediments depend on the physiochemical form in which they occur [1]. Heavy metals are distributed throughout soil and sediment components and associated with them in various ways, including adsorp‐ tion, ion exchange, precipitation and complexation and so on [2]. Changes in environmental conditions, such as temperature, pH, redox potential and organic ligand concentrations, can cause metals to be released from solid to liquid phase and sometimes cause contamination of surrounding waters in aquatic systems [3]. They are not permanently fixed by soil or sediment. Therefore, it cannot provide sufficient information about mobility, bioavailability and toxicity of metals if their total contents are studied alone.


Objective To explore the therapeutic effect and nursing of 16 myomas of uterus treated with radiofrequency ablation. Methods 16 patients with uteri ne myoma were treated with radiofrequency ablation under-ultrasound. Before oper ation, full preparation was performed, the sense, complexions and vital signs we re observed during treatment, and after treatment, pains in belly, bleeding of v agina, fever were closely monitored to prevent infection. Results All the patie nts were successfully treated. Re-examinations 3 months and 6 months after opera tion were conducted by B-ultrasound: 14 myomas of uterus disappered, 2 shrank. D uring treatment, arrhythmia once slowed down to 46 beats/min and went up to 76 b eats/min after infusing 0.5 mg atropine. There were no injuries in organs in abd ominal cavities and no infections in pelvic cavities. Conclusion The treatment of myomas of uterus with radiofrequency ablation has the advantages of using no operating scalpel, safety, effectiveness, simplicity in operation, less pains, less adverse reaction, lower rate of complications. As a new minimally invasive therapy for myomas of uterus, it is safe and effective.


Based on its production,circulation and reserve situatoin,food security problem in Guangdong was analyzed in this article.Forecast and evaluation were made on the target,supply and demand for the food security in Guangdong in the near future.Countermeasures were proposed to improve the food compositive productivity,expand the reserve scale properly,adjust the structure of food reserve varieties reasonably and perfect the control mechanism of market.


This paper analyzes the factors affecting the rural workers' m igration, in particular, the role of human capital and social resources, with th e figures collected in their survey in Jiangsu's farm households. The logit mod el was applied in the empirical analysis. The results indicate clear difference between workers with different education background. Experience in non-farming e mployment plays an important role; training tends to raise quality of human capi tal, and relation between available social resources and mobility is considerable


Dissertation for the degree of philosophiae doctor (PhD)Department of Social Work, Child Welfare and Social Policy Faculty of Social Sciences.
Utgivelsesdata
Tittel:When Divergence Appears Cohorent: An Investigation of How Ambigous Policy Rationales Shape the Activation Trajectories of Hard-to-employ ClientsForfatter(e):Ida SolvangSerie:HiOA avhandlingerIssn:1893-0476Nr:2017 nr 6Utgiver:HiOAAvdeling/fakultet:SAMSider:195Pris:295,– ISBN-print:978-82-8364-053-3


Epicallima icterinella (Mann, 1867), an interesting Oecophoridae species, present only in the Balkan Peninsula and in the islands of Cyprus and Crete, was found for the first time in Italy in Basilicata.


By integrating the endogenous theory of economic growth into the analytical framework of spatial economics,the present paper focuses on the effect of human capital flow on industrial agglomeration and the core- periphery regional welfare level. The study shows that:( 1) the economic growth rate strengthens in line with the concentration of human capital.( 2) There are two stable " core- periphery" types of structural economic space,when knowledge technology and scientific research personnel can flow freely.( 3)when the economic growth rate produced by agglomeration of the RD department is greater than the welfare loss in the periphery region caused by the rise of the price of manufacturing goods. In the"core- periphery"structure,employees' welfare level can achieve Pareto optimality.


Support vector machine (SVM) considers all data points with the same importance in classification problems, therefore SVM is very sensitive to noisy data or outliers. Current fuzzy approach to two-class SVM introduces a fuzzy membership to each data point in order to reduce the sensitivity of less important data, however computing fuzzy memberships is still a challenge. It has been found that the performance of fuzzy SVM highly depends on the computation of fuzzy memberships, hence in this paper, we propose a new method to compute fuzzy memberships and we also extend the fuzzy approach for two-class SVM to one-class SVM. Experiments performed on a number of popular data sets to evaluation the proposed fuzzy SVMs show promising classification results.


This paper discusses degrees of urbanity or urbanities using ethnographic data from research conducted among the Grecanici communities in the city of Reggio Calabria, south Italy. Urbanization in south Italy is usually associated with social and territorial mobility, education and natural disasters. It is further discussed in terms of a rural/urban duality that masks rather than reveals possible diversities concerning the social life in the city and the links between rural and urban which in the urban environment follow different trajectories. Following the premise that the effects of urbanization cannot be homogenously felt by the actors, I follow the Grecanici migration to the city of Reggio Calabria in the decade of the 1950s in order to argue that urbanities are directly informed by factors such as kinship, neighbourhood identification, education and socio‐economic status.


I. In tro duc tion. II. The tasks of bioethics. III. Ethical de bates at the un cer tain bor ders. IV. "There may be valu able sci en tific knowl edge which it is mor ally im pos si ble to ob tain...". V. For bid den knowl edge. VI. Four sets of ques tions about the eth ics of re search. VII. Nor ma tive is sues: three "bright lines" long been lim its on re search. VIII. In sum mary. IX. Con clu sion and rec om men da tions: cre at ing a civic wit ness.


Objective To review the clinical and histopathologie features and discuss the guidelines for surgical management of subconjunctival choristoma in children.Methods A retrospective study of 34 patients with subconjunctival choristoma who underwent surgical excision was reviewed.Results Of 34 patients,there were 17 males and 17 females.All patients had solitary lesions.Mean age when choristoma was discovered was 3 months old(range from 8day to 2years).Mean age at the time of diagnosis was 2.6years (range from 2months to 12 years).The presenting symptom was a subconjunctival mass in all 34 patients.The tumor occurred on temporal quadrant in 33 cases,on nasal quadrant in 1 case,almost of them were near lateral canthus.The mass was tightly adhered to bulbar eonjunctiva but not fixed to the under fascia.The mass was continuous with orbital fat.Transverse plain CT scan was performed in 19 patients,ereseent-shaped hypodensity lesion attached to the epibulbar was detected in all cases on CT scan,CT density was-53 to-106HU,contrast enhanced CT scan in 6 cases.The lesion had a thin wall(1-2mm)under the conjunctiva lateral and could have middle enhancement.In pathology,there were 29 dermolipomas,1 dystopia lacrimal gland,2 heterotopic salivary glands,1 dermolipoma with heterotopic salivary glands,1 osteoearcinoma.Spontaneous regression was never observed,after surgery,1 recurrence,1 atretoblepharia,1 alacrimia,1 xeroma with keratitis filamentosa were observed in 34 patients.Conclusions Children subconjuetive ehoristoma is a rare congenital benign tumor.Most of them are dermolipomas.The clinical feature is a soft,amber flat,slowly-growing,subconjunetival tumor.The histopathologle features show two characteristic constructions,the fat and fiber.CT scan shows the lesion's range and characteristics as well as the relationship with the adjacent structures.CT scan has great directive value for operating on these tumors and reducing the complications.The best treatment is surgical excision.

Key words:
Children; Subeonjunetival; Choristoma; Surgery


A courtyard is an essential space for natural lighting and natural convective ventilation of residential buildings in hot-humid climates. This study focuses on the internal courtyard configuration on the thermal performance of long strip houses (LSH) in the hot-climate area of Hainan Island, China. The aim is to identify the best design parameters for the courtyard to improve thermal comfort in modern LSH design. Appropriate strategies, including Mahoney table, field investigation, and CFD simulation, are used to determine thermal performance. As a result, the design guidelines of the courtyard are proposed to optimize the thermal comfort towards energy saving. The study reveals the spatial characteristics and climate regulation of internal courtyards in traditional LSH. In addition, the simulation results show that the enclosure with a shaded cover and a high ratio of H/D is conducive to thermal environment and ventilation, and the section of contracted shape from bottom to top is a preferred option in the internal courtyard configuration. This study should, therefore, be of value in designing practical projects with an interior courtyard for architects.


This paper introduces the design scheme of a smart fuze for new torpedo. An electronic SA devices (ESADs) was adopted as the safety system of the fuze. The explosive train is a in-line system which uses slapper detonator.The fuze can be easily tested before it is fixed into the warhead,thus improving its battle performance. The fuze consist of an acceleration sensor unit, an ESADs, a safe electronic detonating unit and a detonator complex unit. It was designed integratively. The safety system of the train torpedo fuze is reversible.


In this work, the detection performance of a low-frequency (narrow-band) metal detector by the horizontal spatial distribution of the scattered electromagnetic waves from a buried conducting object in the soil is examined with wave equation based Quasi-Static Finite-Difference Time-Domain method in two-dimensional Cartesian coordinates. The problem space is constructed with a transmitter/receiver, air-ground interface and a square cross-sectioned buried non-magnetic conducting object in the soil. Second order Mur type boundary condition is used to terminate the numerical problem space. The receiver and transmitter (monostatic) antennas are modeled as point sources. The received signals are obtained from the time domain scattered wave data by moving the antenna at a certain height above the ground along a straight line. Then Fast Fourier Transform is applied for passing through to the frequency space. The spatial distribution of the scattered wave is obtained along to the straight line. According to the numerical results, the detection of the buried object is successful, because of enough strong differences observed significantly over the scattered wave on the vertical axis of the buried object. For the performance analysis, the comparisons for different heights of the metal detector antenna and different depths of the buried object are investigated.


Both, common gene variants and human adenovirus 36 (Adv36) are involved in the pathogenesis of obesity. The potential relationship between these two pathogenic factors has not yet been investigated. The aim of our study was to examine the association of obesity susceptibility loci with Adv36 status. Genotyping of ten gene variants (in/near TMEM18, SH2B1, KCTD15, PCSK1, BDNF, SEC16B, MC4R, FTO) and analysis of Adv36 antibodies was performed in 1,027 Czech adolescents aged 13.0-17.9 years. Variants of two genes (PCSK1 and BDNF) were associated with Adv36 seropositivity. A higher prevalence of Adv36 antibody positivity was observed in obesity risk allele carriers of PCSK1 rs6232, rs6235 and BDNF rs4923461 vs. non-carriers (chi(2)=6.59, p=0.010; chi(2)=7.56, p=0.023 and chi(2)=6.84, p=0.033, respectively). The increased risk of Adv36 positivity was also found in PCSK1 variants: rs6232 (OR=1.67, 95 % CI 1.11-2.49, p=0.016) and rs6235 (OR=1.34, 95 % CI 1.08-1.67, p=0.010). PCSK1 rs6232 and BDNF rs925946 variants were closely associated with Adv36 status in boys and girls, respectively (chi(2)=5.09, p=0.024; chi(2)=7.29, p=0.026). Furthermore, PCSK1 rs6235 risk allele was related to Adv36 seropositivity (chi(2)=6.85, p=0.033) in overweight/obese subgroup. In conclusion, our results suggest that obesity risk variants of PCSK1 and BDNF genes may be related to Adv36 infection.


A highly integrated millimeter wave communication active phased array antenna has been developed to meet the demand of a new generation of 5G millimeter wave communication. It has a high gain for compensation of millimeter wave transmission loss. It can generate multi-beams for multi-user by beamforming to multiplex time-frequency resources with a interference suppression between multiple users. The highly integrated millimeter wave communication active phased array antenna has a wide scanning range, a high emission EIRP value, a good cross-polarization characteristics, a high-speed realtime beam control, and a good interactive performance of the host computer software. It has a system verification to meet the need for a new generation of 5G millimeter wave broadband communications. 5G millimeter wave phased array antenna test result for brandband communication shows that data transmision rate is more than 2.8 Gbps with a spectrum width of 800 MHz and a modulation of 64 QAM. At the same time, highly integrated millimeter wave communication active phased array antenna can be applied to satellite communications and tactical mobile hotspots, etc.


Phosphoenolpyruvate carboxylase(PEPC;EC 220.127.116.11) plays an important role in photosynthesis.To get a deeper insight into the PEPC gene of Porphyra haitanensis T.J.Chang et B.F.Zheng(Bangiales,Rhodophyta),we cloned a partial-length cDNA by homology cloning and RACE.This sequence includes 2538bp encoding a propetide of 846 amino acid residues.The deduced polypeptide shows high identities with the PEPC genes ranging from bacteria and unicellular algae to green plant.Phylogenetic tree analysis shows that he PEPC gene from the Porphyra haitanensis is a C3-like PEPC and more closely related to the ancestral type.


In urban areas, typhoons frequently cause the tilting and uprooting of trees, resulting in damage to city infrastructure. During periods of intense rainfall, at shallow soil depths, soil water content is typically high, reducing the anchoring resistance of tree roots in the soil. Tree root systems play an important role in providing anchoring resistance against severe winds during typhoons. In this study, we examined the influence of high soil saturation on the turning resistance of trees by conducting winching tests on three tree species found in urban areas. In highly saturated soils, the maximum resisting moment of camphor trees (Cinnamomum camphora (L.) J. Presl.) is 35–50% lower than in soils with low saturation levels. A tree's maximum resisting moment (TMmax) exhibits a linearly positive relationship with its diameter at breast height (DBH) in near-saturated soil conditions. The ratio of TMmax values to DBH in near-saturated soils is noticeably lower than in low-moisture soils. Our research establishes a relationship between the DBH of trees and the strength of the wind that they can resist during typhoons, as measured on the Beaufort scale.


The invention provides a multilayer dry kiln tray which is of a multilayer structure. The multilayer dry kiln tray is divided into three layers, wherein the bottom layer is a steel frame layer, the middle layer is a metal pore plate layer and the upper layer is a sponge layer. The bottom layer of the tray is of a steel frame structure, so that the mechanical property is improved to a great extent, and the technological requirements are met. A stainless steel pore plate is adopted in the middle layer, so that the structure is further stabilized and breathability is improved. Sponge tissue is adopted in the upper layer so that a newly-formed product rudiment can be better protected and breathability can be improved. The multilayer dry kiln tray is compact and reasonable in design and convenient to detach, install and maintain.


Abstract. Measurements of the water-relation parameters of the giant subepidermal cells (volume, V= 0.119 to 1.658 mm3; = 0.53±0.35 mm3, SD, n= 23) and the smaller mesocarp parenchyma cells (V= 0.10 to 0.79×10−3 mm3; = 0.36±0.27×10−3 mm3, SD, n= 6) of the inner pericarp surface of Capsicum annuum L. were made using the Julich pressure probe. The volumetric elastic modulus ɛ for the large cells was between 1.5 and 27 MPa for a pressure range of 0.09 to 0.41 MPa. For the small cells ɛ was 0.1 to 0.6 MPa for a pressure range of 0.22 to 0.39 MPa. The turgor pressure P, the half-time of water exchange T1/2, and the hydraulic conductivity Lp were as follows, with SD and number of replicates: large cells, P= 0.27±0.06 MPa (23), T1/2=2.7±2.2 s (46), Lp=5.8±3.7 pm s−1 Pa− (46); small cells, P= 0.33±0.07 MPa (6), T1/2= 33±10s (12), Lp=0.21±0.07 pm s−1 Pa−1 (12). The determination of these basic water-relation parameters is considered as a prerequisite for future ecotoxicological and phytopathological studies. The differences between the large and the small cells are discussed in relation to a desirable biophysical definition of succulence. Further, for the large cells a pressure and volume dependence of ɛ was demonstrated.


One long-standing challenge in robotics is the realization of mobile autonomous robots able to operate safely in existing human workplaces in a way that their presence is accepted by the human occupants. We describe the development of a multi-ton robotic forklift intended to operate alongside human personnel, handling palletized materials within existing, busy, semi-structured outdoor storage facilities. The system has three principal novel characteristics. The first is a multimodal tablet that enables human supervisors to use speech and pen-based gestures to assign tasks to the forklift, including manipulation, transport, and placement of palletized cargo. Second, the robot operates in minimally-prepared, semi- structured environments, in which the forklift handles variable palletized cargo using only local sensing (and no reliance on GPS), and transports it while interacting with other moving vehicles. Third, the robot operates in close proximity to people, including its human supervisor, other pedestrians who may cross or block its path, and forklift operators who may climb inside the robot and operate it manually. This is made possible by novel interaction mechanisms that facilitate safe, effective operation around people. We describe the architecture and implementation of the system, indicating how real-world operational requirements motivated the development of the key subsystems, and provide qualitative and quantitative descriptions of the robot operating in real settings.


In this study, related to the design of sex education by Logo students living in the city of Kisangani in the Democratic Republic of Congo, we worked with a sample of 80 subjects from six institutions of higher education and university. Using the survey method, data collection was done using a questionnaire. In the end, we realized the respondents have a varied consequence of sexuality. The purpose of sexuality is multiple, including offspring, exercising in future marital life, discovering each other and having fun with the opposite sex partner. Respondents also expressed a negative opinion about pre-marital sexuality, although they were interested in any discussion of sexuality. The experience of morality and sexuality is at once disordered, commerce, sometimes a voluntary act. The nature of sexuality is to be discouraged. For some, it is imposed, while for others, it is responsible and does not prepare for married life. Similarly, the respondents stated that they were not introduced to morality and sexuality, although sexuality is considered an initiation to marriage and intimacy. High school is the most cited information channel.


The present invention concerns a pair of contact or capacitive HF couplers for drill stem components. Each of the first and second couplers comprises a central conductor (52), a supplemental conductor (53) and an annular dielectric means (54). The dielectric means is disposed between said conductors. Said conductors are isolated from each other. The supplemental conductor comprises two electrical contact surfaces (56, 57). The central conductor comprises an electrical contact surface or electrode. The central conductors of the first and second couplers interact electrically in the coupled state. The supplemental conductors of the first and second couplers are in electrical contact in the coupled state. The supplemental conductors surround the central conductors. In the mounted state, the supplemental conductors form a shielding for the central conductors.


With increased public concern for pollution of the marine environment, ocean disposal of manmade wastes has become a topic of growing interest. Under contract to the U.S. Environmental Protection Agency, Battel le Ocean Sciences i s conducting an oceanographic monitoring program at the 106-Mi le Deepwater Municipal Sludge Site to determine the fate and effects of sewage sludge dumped at the site. collect physical oceanographic and chemical data from within sludge plumes to determine rates of plume dilution and the effect on water quality within and around the site. The success of the recent studies has been due to an integration of physical and chemical sampling techniques which allows 1) tracking of sludge plumes for periods up to 1 day, 2) collection of hydrographic and current data to resolve plume advection and dilution, and 3) directed water sampling within the plumes for analyses of trace metals and organic compounds. optimum measurement tool for tracking sludge plumes is an in situ transmissometer interfaced to a CTD profiler and Loran-C navigation system to provide real-time, 3-dimensional information on plume turbidity. Results from these field studies will be presented, and the use o f this measurement capability for other pollution monitoring programs will be discussed. A series of cruises has been conducted to


OBJECTIVES: Following right upper lobectomy, the right middle lobe may shift towards the apex and rotate in a counterclockwise direction with respect to the hilum. This study aimed to investigate the incidence and clinical impact of middle lobe rotation in patients undergoing right upper lobectomy. METHODS: From January 2014 to November 2018, 82 patients underwent right upper lobectomy at our institution for lung cancer using a surgical stapler to divide the minor fissure. Postoperative computed tomography scans evaluated the counterclockwise rotation of the middle lobe, in which the staple lines placed on the minor fissure were in contact with the major fissure of the right lower lobe (120 counterclockwise rotation). Clinicoradiological factors were evaluated and compared between patients with and without The first two authors contributed equally to this work. TH O R A C IC VC The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/bync/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact firstname.lastname@example.com Interactive CardioVascular and Thoracic Surgery (2021) 1–9 ORIGINAL ARTICLE https://doi.org/10.1093/icvts/ivab356 D ow naded rom http/academ ic.p.com /icvts/advance-art.1093/icvts/ivab356/6469645 by gest on 28 D ecem er 2021 middle lobe rotation. We also reviewed surgical videos in patients with middle lobe rotation to evaluate the position of the middle lobe at the end of surgery. RESULTS: Nine patients had a middle lobe rotation (11%), where 1 patient required surgical derotation. Patients with middle lobe rotation were significantly associated with more frequent right middle lobe atelectasis and severe postoperative complications compared with those without rotation. A surgical video review detected potential middle lobe rotation at the end of the surgery. CONCLUSIONS: Middle lobe rotation without torsion following right upper lobectomy is not rare, and it is associated with adverse postoperative courses. Careful positioning of the right middle lobe at the end of surgery is warranted to improve postoperative outcomes.


The ATLAS muon detector is designed to attain precision muon momentum resolution aided by an embedded optical beam network which monitors thermally induced chamber displacements. We report on the ability of this alignment system to provide corrections for track reconstruction. This work is based on sagitta measurements conducted at the CERN H8 2003 test beam.


Abstract Introduction : In order to analyze the effectiveness of the physiotherapeutic treatment in patients with chronic neck pain, this work had as a goal to evaluate the period before and after the physiotherapeutic treatment: quality of life as a WHOQOL–100 tool and the improvement of the range of motion (ROM), using a goniometer. Materials and meth-ods : 15 patients were members of this study (10 women and 5 men). Results : Level of signi ficance adopted was p < 0.05.It was observed significant improvement after physical therapy in the domain I – physical (p = 0.0117), in domain II – psychological (p = 0.004), the domain III – level of independence (p = 0.0006), domain IV – social relationships(p < 0.0001) and domain V – environment (p = 0.0019) and also in joint range of motion of cervical flexion (p < 0.0001), cervical extension (p = 0.0004), right head tilt (p < 0.0001), left head tilt (p < 0.0001) right lateral rotation (p < 0.0001) and left lateral rotation (p < 0.0001).


Seamounts have long been recognised as hotspots for pelagic productivity and diversity in the world's open ocean habitats. Recent studies have suggested that productivity may vary greatly between different seamounts, depending on complex interactions between the bathymetric features and local oceanography. These processes may enhance local primary production which support elevated biomass at higher trophic levels. In addition to enhancing local biomass, seamounts may also act as aggregative features, attracting pelagic species from the surrounding waters. Such characteristics make seamounts attractive targets for fisheries. However, as these unique habitats are localised and relatively small, they are vulnerable to overexploitation, which may have detrimental impact on the wider region. Mapping and quantitative assessments of the fish biomass at different seamounts are crucial prerequisites to identifying vulnerable seamounts and will aid toward understanding the dynamics of these important ecosystems and their vulnerability to fishing pressures. We used fisheries acoustics during two expeditions in 2018 and 2019, to investigate the distribution and abundance of fish and micronekton on and around five little studied seamounts of Tristan da Cunha, a remote archipelago in the South Atlantic Ocean. The results confirmed increased productivity at the seamounts, compared to the surrounding open ocean with higher acoustic backscatter values, a proxy for biomass, particularly at the shallower (~200 m depth) seamounts. Fish largely dominated the backscatter on most of the seamounts especially over the plateau areas where large densities of prey fish, primarily the mesopelagic Maurolicus inventionis, were detected. Very large aggregations, thought to consist of bentho-pelagic fish, were also observed over the slope of McNish Seamount that resulted in very high biomass estimates. Aggregations of this size and magnitude, have, to our knowledge, never been mapped or quantified on seamounts, using acoustic methods. Specific physical processes, such as enhanced retention and vertical mixing that were identified by an oceanographic model, may be some of the drivers of the enhanced fish biomass detected at McNish. The characteristics of the seamounts observed in this work suggest that these habitats are highly suitable for the presence of large predatory fish that can utilise these areas as their primary habitat or as important foraging grounds.


French has three types of polar questions: an interrogative with est-ce-que, or an inverted clitic, or a questioning declarative clause: est-ce-que-clause Est-ce que Paul sera la ? (will Paul be there ?) inv-clause Paul sera-t-il la ? Q-declarative Paul sera la ? Marandin 2005, Beyssade-Marandin 2006 argue that Q-declaratives in French, unlike interrogatives, have a content of type proposition, and make hypotheses about their use. The only corpus studies available are Mosegaard-Hansen 2001 with 4h35' recording (83% of the polar questions are Q-decl), and Bazillon et al. 2011 with the EPAC corpus (20h of a radio talk show 'le telephone sonne') who find an more even distribution (28% inv-cl, 31% Q-decl, and 39% est-ce-que-cl), with a preference depending on speaker's status: inv-cl for callers, est-ce-que-cl for experts and Q-decl for the host. We use the same radio corpus with further parameters, to study the differences among the three types. Q-declaratives differ from interrogatives, in being compatible with epistemic markers and question tags, like other declaratives : (1) on va commencer peut-etre avec Etienne Boisserie ? ('we'll start maybe with E B ?') (2) le seul moyen de trouver du travail en Irak, c'est dans les services de securite, non ? ('the only mean to find a job in Iraq, it's in the security services, no ?') Q-declaratives resemble interrogatives in expecting an answer, but they differ in their response type: 74% get a confirmation, but only 29% of the est-ce-que-cl and 26% of the inv-cl. Q-decl also differ from interrogatives by their appeal to the addressee: 45% use a 2d person subject (only 7% of the est-ce and 14% of the inv-cl); 47% use a vocative (only 11% of the est-ce-que and 13% of the inv-cl). Unlike an interrogative, a Q-decl presents a proposition, but the speaker hands it over to the addressee to endorse it (Abeille, Godard, Marandin 2013). Q-decl are never used by callers, who ask for information or advice; they are mainly used by the host for conversation management (1) and topic management, with the discourse topic often presented as left or right dislocated (2,3): (3) [about a new cancer hot line] il est d'ores et deja operationnel ce numero ? (it's already in service, this number ?) To test our observations, we annotate the corpus with 9 parameters: speaker's status, subject person, vocative, coordination, dislocation, tag, tense, response type, conversation management. We fit three mixed effect logistic regression models, each predicting a clause type given the annotated factors. It remains to be seen whether our results hold in other corpora and other dialog situations.


The dance work "Nafas Nusantara" is a new dance creation that departs from the motion of representing four regions, Java, Malay, Bali, and Borneo. Nafas Nusantara is a form of virtual performance work produced as an opening ceremony in the virtual INTERNATIONAL MULTIDISCIPLINARY RESEARCH CONFERENCE ON EDUCATION, SCIENCES AND ARTS (IMReCESA 2021) held in the Philippines. Nafas Nusantara dance works through different stages of production from dance works are live show, the production of Nafas Nusantara works through the stages: pra-production, production, and post-production, where pre-production consists of 4 stages of preparation such as: Drafting the work concept, compiling a production schedule, making storyboards, and forming a production team. Production stage with the process of forming dance and music accompaniment, documenting dance works with cinematographic techniques. The last post-production is the editing and mastering process.


Objective: To prepare dropping pills and control its quality.Methods: The preparation techniques were studied based on the the proper proportion among matrix,puerarin and total flavonoids in the dropping pills,and the puerain content in the dropping pills was determined by TLC.Results: The matrix was PEG4000.The ratio of matrix and total flavonoids was 1∶8,and the mixture storage temperature was kept at 90 ℃.Liquid paraffin was refrigerant.Internal and external diameters of burette were equal to 1.9mm and 2.5mm.Drug was dripped into the refrigerant at 15 ℃ with 50 drops per minute.Moulding probability was high.Conclusion: The procedure for the preparation is feasible and method for quality control is reliable.


Abstract The planar dipole reader antenna using a dual polarization, which consists of two dipole radiating patches and Wilkinson power divider, is presented. The electric cross dipole is added to generate a symmetric radiation pattern and to compensate the high back radiation due to the shortened patches. From experimental results, the measured impedance bandwidth of the antenna (defined by −10 dB return loss) is 30 MHz (907 MHz–954 MHz, Korea standard = 917 MHz–923.5 MHz). Simulated isolation between the two input ports is over 35 dB. The measured gain of the proposed antenna is stable with frequency. The average gain is about 6.3 dBi.


Teachers enrolled in a professional development program involving artists on site at cultural institutions participated in a study in which they expressed their views on upgrading in the arts. Findings indicate that they were influenced in their own schooling by passionate teachers who conveyed the importance of the arts. Their progress was impeded by a self-perception of their own limited artistic ability. Community experiences, such as private lessons and amateur productions, played a more significant role in their development. The ideal scenario for their personal and professional development in the arts is an environment where discipline-based and integrative curricular activities are offered, and both the creative process and the creative product are valued. Lack of personal expertise, limited professional development opportunities, and inadequate funding are obstacles that can be overcome by teacher commitment to upgrading in the arts, a range of arts courses offered by education faculties, and involvement by arts stakeholders in program design and delivery, respectively.


The pharmaceutical industry relies heavily on the synthesis of small quantities (10–500 mg) of stable, isotopically labelled compounds in the evaluation of new drug candidates for metabolism studies. As a result of the phenomenal cost of labelled materials even the preparation of small quantities can be extremely expensive.

In this paper, for the first time, we report that micro-reactor technology may be used to prepare stable deuterium-labelled compounds by conducting all optimization experiments using unlabelled precursors and simply substituting the labelled derivatives once the optimization is complete. Here, we wish to present a simple, general procedure for the synthesis of amides containing isotopic labels demonstrated using [C-2H3]acetyl chloride 1. The reaction is carried out within a micro-reactor set-up which we believe offers superiority over other reported methods viz requiring stoichiometric quantities of reagents, high containment of the system and generality of the technique, obtaining products in high yields. Copyright © 2007 John Wiley & Sons, Ltd.


A resin composition giving a cured article which is reduced in curing shrinkage, has high optical transparency, and is excellent not only in optical properties including light resistance and resistance to thermal discoloration but in mechanical properties including breaking strength. The resin composition is a two-pack type resin composition composed of: a liquid (A) which is a polyol ingredient comprising a polycaprolactone polyol having a functionality of 3 or higher; and a liquid (B) which is an isocyanate ingredient comprising an alicyclic diisocyanate and a hindered phenol antioxidant.


The paper investigates corporate governance and social responsibility from the perspective of stakeholders.The paper takes fulfilling social responsibilities as an important criterion by which we can judge whether manager are fulfilling their social responsibilities or not,and thinks that the essence of social responsibility is the reflection of the relationships of the benefits and accountabilities of all stakeholders.The theory of stakeholders enlarges the scope of principals of corporate.However,it is not a burden but a need for long term development for corporate in deep thought.The supervision mechanism based mainly on relatively independent third party has the adveantage over the other supervision mechanism,and plays the dual role of the bridge and buffering zone between managers and stakeholders.


Premise. The present study was designed to examine the scope of morbidity facing children with end-stage renal disease (ESRD). Methods. Morbidity data were collected prospectively during three separate periods from October 2001 through April 2003 from all children (age 1-18 yr) maintained on either chronic hemodialysis (HD) or peritoneal dialysis (PD) within the ESRD Network of New England (Network 1). Data were obtained on 26 HD patients (age 14.5 ± 2.9 yr) (mean ± SD) and 33 PD patients (age 12.5 ± 4.6 yr). Results. Despite the use of recombinant human erythropoietin, anemia (hemoglobin < 11 g/dl) was often noted (48.9% of observations in PD patients vs. 33.3% of observations in HD patients). A low serum albumin (< 3.5 g/dl) was seen commonly in PD patients (53.2% of observations in PD patients vs. 11.9% of observations in HD patients). Growth failure (height percentile <2 SD from age-adjusted norms) occurred in 36% of the patients and correlated directly with years of renal failure (p < 0.001). Dialysis access malfunction, dialysis access-related infection, and hypertension accounted for most of the patient morbidity and nearly all of the hospitalizations. Access failures happened in < 10% of PD cases and in one-third of HD cases. HD access failures were twice as common with central venous catheters and arteriovenous grafts as they were with arteriovenous fistulas. Approximately one-third of HD and PD patients experienced an access-related infection. Hypertension was recorded more often in HD patients (in 36% of observations in PD patients vs. 48% of observations in HD patients). Hospitalization was necessary in 75% of the cases of access failures, 85% of the cases of dialysis access-related infections, and 40% of the cases of hypertension. Conclusions. Opportunities exist for quality improvement in anemia management, nutrition, dialysis access, and treatment of hypertension in U.S. pediatric dialysis patients.


In the past century, blood group determination using serology has been the standard method. Now, molecular methods are gaining traction, which provide additional and easily accessible information. Here we designed and validated a high‐throughput extended genotyping setup.


1. Grygiel‐Górniak B, Puszczewicz M, Czaplicka E. Susac syndrome‐clinical insight and strategies of therapy. Eur Rev Med Pharmacol Sci 2015;19:1729‐35. 2. Susac JO, Murtagh FR, Egan RA, Berger JR, Bakshi R, Lincoff N, et al. MRI findings in Susac's syndrome. Neurology 2003;61:1783-7. 3. Petersen KD, Landsfeldt U, Cold GE, Pedersen CB, Mau S, Hauerberg J, et al. ICP is lower during propofol anaesthesia compared to isoflurane and sevoflurane. Acta Neurochir Suppl 2002;81:89-91. 4. Reinstrup P, Ryding E, Algotsson L, Berntman L, Uski T. Effects of nitrous oxide on human regional cerebral blood flow and isolated pial arteries. Anesthesiology 1994;81:396‐402. 5. Soldatos T, Karakitsos D, Chatzimichail K, Papathanasiou M, Gouliamos A, Karabinis A. Optic nerve sonography in the diagnostic evaluation of adult brain injury. Crit Care 2008;12:1.


We have recently published a paper entitled "Superhydro-phobic Aligned Polystyrene Nanotube Films with High Adhe-sive Force" in Advanced Materials . [1] This work reported the preparation of superhydrophobic aligned polystyrene (PS) nanotube films with a high static contact angle (CA) of about 162° and a high adhesive force. The as-prepared films have been used to transfer small water droplets without mass loss, as assessed by a high-sensitivity microelectromechanical balance system. Indeed, the results point to the occurrence of a new superhydrophobic phenomenon. Some readers have been perplexed by these results and have raised several questions about this new superhydrophobic phenomenon. [2] Moreover, other researchers have expressed a different opinion about whether a superhydrophobic surface should exhibit a low CA hysteresis. [3] Considering the current confusion in understanding superhydrophobicity, we attempt here to clarify the definition of superhydrophobic states. We hope that this clarification will help readers obtain a better understanding of interesting superhydrophobic phenomena on solid surfaces. In general, surfaces with a static CA higher than 150° are defined as superhydrophobic surfaces. As for the details of CA hysteresis, [4–8] five states are possible for superhydrophobic surfaces (Fig. 1): Wenzel's state, Cassie's state, the so-called "Lotus" state, the transitional state between Wenzel's and Cassie's states, and the "Gecko" state.


In this paper, the performance of hydrophobic coating on glass coupons and photocatalytic hydrophilic coating on solar modules installed in hot desert climate is analyzed using different test methods. Results reveal that after one month of outdoor exposure, and before cleaning the samples, the transmittance of uncleaned coated coupons reduced by 12.5% in comparison to 17.6% for the uncoated coupon. This result confirms the anti-soiling effect of the coating. After cleaning, the transmittance of the coated glass coupons under light exposure was slightly higher than coated coupons placed under shade, as well as higher in comparison to the uncoated coupons. This phenomenon could be caused by the degradation of the coating layer by light and high temperature. It is also observed that the wetting angle reduces with light exposure. In addition, the external quantum efficiency peak of the uncoated solar module was found to be higher than the coated module by approximately 1%. The I-V curves show higher power losses over the exposure time for coated module due to light soaking. These results provide an insight into the actual performance of different commercial anti-soiling coatings under hot desert conditions.


Natural circulation loop passively conveys heat from heat sources to heat sinks without mechanical pump. Various plants have natural circulation systems, e.g., solar heaters, Light Water Reactor (LWR) and Liquid Metal Fast Breeder Reactor (LMFBR). The core of LMFBR is cooled by forced convection of single-phase liquid sodium in normal operation. After the accident, the decay heat of the core is designed to be cooled by the natural circulation of the liquid sodium. The natural circulation cooling is very important from a viewpoint of passive safety concept. Here, the natural circulation in single loop system had been studied by many researchers. In a multiple loop system, the instability of natural circulation was more complicated because of the interaction between the loops. In this study, the effects of the multiple loop on the natural circulation instability were investigated numerically. The multiple loops system with one heating tube and two cooling tubes were evaluated. The one-dimensional energy and momentum equations were solved using Finite Difference Method. The flow regimes of the instability were evaluated with varying the heat flux. In multiple loop system, the observed flow was classified into five regimes including chaotic regime. The flow regimes were qualitatively explained by themore » stability of the attractor in the phase space.« less


Peak-to-total ratios have been extracted for a segmented clover detector for various modes of operation and suppression cases. Based on absorption and scattering of gamma-rays, a formalism has been presented for quantifying the advantages of using addback mode and active suppression. Further investigations have been performed to find if the reduction of background counts is caused more by active suppression or by addback process.


In developing countries the prevalence of anaemia among pregnant women averages 56%, ranging between 35 to 100% among different regions of the world. Various studies from different regions of the country (India) have reported the prevalence of anaemia to be between 33 and 100%.In India, anaemia is the second most common cause of maternal deaths, accounting for 20% of total maternal deaths. Anaemia affects mainly the women in child bearing age group, young children and adolescent girls. Association of anaemia with adverse maternal outcome such as puerperal sepsis, ante-partum haemorrhage, post-partum haemorrhage and maternal mortality is no longer a debatable subject. Folic acid and vitamin B12 are essential in the synthesis of nucleoprotein, particularly of erythropoietic cells. Hence this study is taken to study the serum levels of Folic acid and vitamin B12 in pregnant ladies and correlate with seviarity of anaemia.


This article was written to explain the material regarding curriculum administration. As for the method used and writing this article is the method of studying literature by collecting materials and materials both from books, journal, articles, and other sources relating to curriculum administration. The conclusion of this article is that the curriculum is a design and regulation regarding the content and learning material as well as the methods used as a guide in the implementation of the teaching and learning proces. The curriculum has a very important role in the world of education which is to determine and guide the direction in implementing the educational process in order to achieve educational goals.


Spectral classification plays a crucial role in the analysis of astronomical data. Currently, stellar spectral classification primarily relies on one-dimensional (1D) spectra and necessitates a sufficient signal-to-noise ratio (S/N). However, in cases where the S/N is low, obtaining valuable information becomes impractical. In this paper, we propose a novel model called DRC-Net (Double-branch celestial spectral classification network based on residual mechanisms) for stellar classification, which operates solely on two-dimensional (2D) spectra. The model consists of two branches that use 1D convolutions to reduce the dimensionality of the 2D spectral composed of both blue and red arms. In the following, the features extracted from both branches are fused, and the fused result undergoes further feature extraction before being fed into the classifier for final output generation. The data set is from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope, comprising 15,680 spectra of F, G, and K types. The preprocessing process includes normalization and the early stopping mechanism. The experimental results demonstrate that the proposed DRC-Net achieved remarkable classification precision of 93.0%, 83.5%, and 86.9% for F, G, and K types, respectively, surpassing the performance of 1D spectral classification methods. Furthermore, different S/N intervals are tested to judge the classification ability of DRC-Net. The results reveal that DRC-Net, as a 2D spectral classification model, can deliver superior classification outcomes for the spectra with low S/Ns. These experimental findings not only validate the efficiency of DRC-Net but also confirm the enhanced noise resistance ability exhibited by 2D spectra.


A new mechanism leading to scale-free networks is proposed in this letter. It is shown that in many cases of interest, the connectivity power-law behavior is neither related to dynamical properties nor to preferential attachment. Instead, we show that without increasing the number of vertices in time and without applying the so called {\it ``rich-get-richer''} condition we obtain networks whose statistical properties are scale-free. Assigning a quenched fitness value $x_i$ to every vertex, and drawing links among vertices with a probability depending on the fitnesses of the two involved sites, gives rise to what we call a {\it ``good-get-richer''} mechanism, in which sites with larger fitness are more likely to become hubs (i.e., to be highly connected). This procedure generates power-law behaviors for various fitness distributions and attaching rules.


Abstract The survey of airborne fungus spores in a Manuscript Library in Madras, India was carried out for a four month period from 1 Aug. till 30 Nov. 1982. Nineteen spore types belonging to 19 genera were identified from the Rotorod traces and 43 species representing 23 genera isolated from exposed Petri dishes. Aspergillus spp. spores were found to be predominant in the library atmosphere and this is revealed by both the techniques. This was followed by Cladosporium and Nigrospora on rotorod traces and Penicillium, Drechslera, Alternaria and Nigrospora on exposed Petri dishes in that order. Cellulose degrading fungi such as Chaetomium, Rhizopus and Trichoderma were commonly isolated.


I Outline of the Subject Community2) The subject communit>r, Kampong Hutan Chengal, is situated in Pasir Mas District, Kelantan State, in the northeastern part of Peninsular Malaysia, Pasir Mas District forms the border between Malavsia and Thailand, situatcd ()n the left side delta of the Kelantan  . river which fiows into the South China Sea through the state, The population of I'ttsir rS'{'as District was 89,971 and the total number of huuseholds 20,735 in 1968. The size of the district is 93,506,7 acres which is categc}rized according to land use pattern as fo]lows: paddy fleld, 51,836,2 acres; rubber holding, 28,263,5 acresl :md othc・rs, ]3,407,O acres.


Abstract 3271 Acute Myeloid Leukemia (AML) is the most common form of adult acute leukemia and the second most common childhood leukemia. AML has the lowest survival rate among leukemias, and the frequency is increasing as the population ages. Current therapies are inadequate, and a need exists for better therapeutic agents to treat AML, both as initial treatment for newly diagnosed patients and for those who have failed current therapy and relapsed. Natural products, such as taxol, have shown activities in a variety of disease states, including cancer. Triptolide is a natural product diterpenoid derived from Tripterygium wilfordii Hook f, and has shown anti-cancer activity in a broad range of solid tumors in preclinical models. It induces apoptosis in various leukemic cell lines and primary AML blasts (Carter, B et al , Blood 2006). Derivatives of triptolide with improved pharmacokinetics and bioavailability offer the opportunity to optimize the activity of triptolide for clinical application in AML. MRx102 is a triptolide derivative that is more hydrophobic than triptolide. It has potent in vitro cytotoxic activity with human tumor and leukemia cell lines, an unusual result for triptolide derivatives because they are usually much less active in vitro than the parent compound. Designed as a prodrug, MRx102 exerts cytotoxic activity with human AML cell lines and other human leukemia cell lines without pre-incubation with plasma esterases (IC 50 of 51.0 and 37.1 nM with MV4-11 AML cells at 48 and 72 hours, respectively, ∼55% and ∼36% of the activity of triptolide, respectively). MRx102 decreases the viable CD34+ blasts of AML patient samples (a mean of 79.8 ± 8.8% specific apoptosis at 100 nM, n=3), and overcomes the apoptosis protection by co-cultivated stromal cells (with a similar mean of 74.1 ± 8.5%). MRx102 shows dose-dependent anti-tumor activity with the MV4-11 cell line in nude mouse human AML tumor xenografts. After 42 days of MRx102 dosing at 1.35 mg/kg/day i.p., tumor volume was inhibited by 99.7%. Tumors removed from several mice appeared to be Matrigel pellets rather than vascularized tumors, suggesting that many of the tumors were completely eliminated. In studies with the OCI-AML3 human AML cell line xenograft model, the group receiving MRx102 at 1.35 mg/kg/day i.p. showed similar high activity, with mean tumor volume reduced by as much as 99.2% on day 23 compared to the vehicle control group. Tumors of 7 of 10 mice were smaller than the day 0 volumes at the day 28 end of the study. As part of drug development, toxicology testing with MRx102 was initiated with an acute single dose rat toxicology study with no deaths and no adverse signs up to the top dose of 3.0 mg/kg MRx102 in DMSO/PBS administered i.v. The maximum tolerated dose (MTD) is greater than 3 mg/kg of MRx102, and the no observable adverse effect level (NOAEL) is at least 3 mg/kg. A 7-day subacute rat toxicology study of MRx102 showed no deaths and no adverse signs up to the top dose of 1.5 mg/kg/day MRx102 in DMSO/PBS administered daily i.v. for 7 days. The histopatholgy report shows no findings related to administration of the test article. The MRx102 MTD is greater than 1.5 mg/kg/day, and the NOAEL is at least 1.5 mg/kg/day. Previously observed NOAELs for related compounds have been less than 0.1 mg/kg/day. The current studies show potent anti-tumor activity as well as an unusually positive safety profile for MRx102 when compared to triptolide and other triptolide derivatives. Further MRx102 drug development is underway, with the intention of submitting an Investigational New Drug application to the Food and Drug Administration leading to clinical evaluation of MRx102 in AML patients. Updated results on current drug development activities will be presented at the meeting. This work is supported in part by NCI SBIR Contract HHSN261200900061C to MyeloRx LLC. Disclosures: Fidler: MyeloRx LLC: Employment, Equity Ownership, PI for an NCI Contract to MyeloRx LLC, Patents & Royalties. An: MyeloRx LLC: Employment, Equity Ownership, participant in research under an NCI SBIR Contract to MyeloRx LLC. Musser: MyeloRx LLC: Employment, Equity Ownership, Patents & Royalties, participant in research under an NCI SBIR Contract to MyeloRx LLC. Mak: MyeloRx LLC: participant in research under an NCI SBIR Contract to MyeloRx LLC. Carter: MyeloRx LLC: participant in research under an NCI SBIR Contract to MyeloRx LLC. Andreeff: MyeloRx LLC: Consultancy, participant in research under an NCI SBIR Contract to MyeloRx LLC.


It is one of the core goals for higher education to establish a scientific and modernized internal governing system in universities. To achieve such a goal,the statue of a university will play a significant role in the improvement of her internal governing structure since it is by nature the constitution of the institution. However,most of the university statutes in China provide no clear specification on their internal governing structure. In other words,the university statues in China have not been brought into full play in maintaining universities' autonomy and academic freedom as well as their internal governing structure. In order to solve these problems concerned,the paper presents a discussion on how to make use of university statues in the construction of such an internal structure.


Where must a clinician turn when straightforward schizophrenia suddenly turns out to be just the opposite? Fortunately, these days, there are protocols for just about everything. But how much value do these add? This article outlines the journey of our attempt to follow one such protocol.


Along history, sociology and literature have formed various associations with each other. From the sociology of literature that has considered literature as a social production to the usages of sociological perspectives as literary theories or the usage of literature as illustration of sociological abstract notions, literature and sociology have been constantly and interrelatedly studied. Nevertheless, this study aims at revealing another interrelation between literature and sociology by referring to the beginning of the twentieth century when the replacement of religious thinking with secular ideas was dominant in modern society. Sociologists like Emile Durkheim detected and studied this shift in modern society and later on literary authors of the time followed the promotion of secularism in their literary works. However, T.S. Eliot reacted to this replacement in his poem "The Love Song of J. Alfred Prufrock". He wrote the poem while he was reviewing Durkheim's The Elementary Forms of the Religious Life in the journal the Westminster Gazette. This paper argues that T.S. Eliot's "The Love Song of J. Alfred Prufrock" is written with a mindset loaded by Durkheim's sociological perspectives such as the notions of the sacred and the profane to further conclude that T. S. Eliot's creation of Prufrock is consistent with the view that the modern man is unable to establish himself in a society which is devoid of the notions of sacred and profane and that he may consider committing suicide to save himself as the final resort.


Abstract Fission fragment angular distributions have been measured for the neutron fission of 230Th across the resonance at 715 keV. A re-analysis of the angular distribution data and the neutron fission cross section is presented.


As mobile node takes a relatively long time to hand over and some packets are lost during these period, TCP performs badly in mobile environment. IETF present seamless handover mechanism, include fast handover and smooth handover, to reduce the delay and packet losses during handover to improve TCP performance. It is taken for granted that the performance of TCP with seamless handover is surely better than that without. However, we find that the performance of TCP especially Reno with seamless handover is worse than that without in some cases through a large number of detailed simulation. We analyze the reason inside the phenomenon and give a solution to solve it. and sometimes even degrade TCP's performance in section 3. Section 4 gives an effective solution. We draw a conclusion in section 5.


Service-Orientation (SO) is a design and integration paradigm that is based on the notion of well defined, loosely coupled services. Within SO, services are viewed as computational elements that expose functionalities in a platform-independent manner and can be described, published, discovered, and consumed across language, platform, and organizational borders. SO principles emphasize composability, by which a set of services can be composed to achieve the desired functionality. Service orchestration is the dominate approach to service compositions. A key issue in implementing service orchestrations is their efficient concurrent execution.
 This paper focuses on the scalability challenges of simultaneously executing many long-running service orchestration instances. We present a novel approach for implementing service orchestrations called BUST (Break-Up State Transition) that significantly improves processing rate and scalability.