Purpose: This study aims to learn more about the hospitality sector in Goa, India, including its current state, potential, and growth. The review plans to distinguish the variables that add to the progress of the cordiality business in Goa, as well as the difficulties it faces in adjusting to changing times and the effect of the Coronavirus pandemic. The concentrate additionally tries to feature the extraordinary elements of the Goan cordiality industry that put it aside from other traveler objections in India.
Methodology: This study employs a secondary research strategy based on a review of previously published articles, reports, and data on the Goan hospitality sector. Google Scholar, ResearchGate, and official Goa Tourism Division publications are used in the study. The information examination centers around key execution markers, for example, inhabitance and room rates in the neighborliness business in Goa.
Findings: Despite the challenges posed by the COVID-19 pandemic, this study reveals that Goa's hospitality industry has performed well in recent years. Hotels in Goa saw a significant rise in occupancy rates from 15% to nearly 55% in the final quarter of 2022. Moreover, the typical room rates expanded from Rs 4,500 to nearly Rs 7,000 every evening. Goa saw the greatest increase in hotel demand among India's level II cities, rising by 118% in April. In addition, the study predicts that Goa's hospitality industry will continue to expand in 2023, surpassing pre-pandemic levels of demand and increasing revenue for the state and local governments.
Practical Implications: Students, researchers, and policymakers interested in Goa's hospitality industry will benefit greatly from this study's practical implications. The study gives a valuable understanding of the industry's current state and growth and development potential. It also emphasizes the Goan hospitality industry's distinctive characteristics that set it apart from other Indian tourist destinations. The discoveries of this study can help partners in the business, including hoteliers, financial backers, and policymakers, to pursue informed choices and to make the most of the amazing open doors introduced by the development of the travel industry in Goa. Also, the review gives bits of knowledge into the effect of the Coronavirus pandemic on the friendliness business in Goa and the actions that have been taken to adjust to the evolving conditions.
Originality/Value: This study gives a canny investigation present status of the Goan Lodging Industry, featuring its advantages, future potential, extraordinary qualities, restrictions, open doors, and qualities for industry advertisers. Even though this report is based on secondary research, it could be improved by having in-person interviews with key stakeholders like hoteliers, tourists, locals, and other industry players. These people would be better able to share their actual experiences and give feedback from the ground up. By providing a more comprehensive understanding of the Goan lodging industry and its overall impact on the Indian tourism industry, such primary research would further enhance this study's value and originality. Policymakers, stakeholders in the industry, and investors interested in the Goan tourism industry who want to make informed decisions may benefit from this study's findings. Moreover, understudies, specialists, and the overall population can profit from this concentrate by acquiring a more profound comprehension of the housing business in Goa and its commitment to the more extensive travel industry.
Paper type: Case Study


Objective To set up a quality standard for Shengfa Tincture.Methods Fructus Psoraleae and Naoyanghua in the prescription were qualitatively identified by thin layer chromatography.The octadecylsilane bonded column was used as the stationary phase,and methanol-water (50:50) as the mobile phase.The column was CAPCELL PAK C18(250 mm×4.6 mm,5 μm),with a detection wavelength of 246 nm and a flow rate of 1.0 ml/min.Results The calibration curve of psoralen was linear over the range of 6.56-65.64 μg,and the equation of linear regression was Y=73 364.32X-3.59(r=0.9999).The calibration curve of isopsoralen was linear over the range of 6.56-65.64 μg,and the equation of linear regression was Y=73 454.85X+4.01(r=0.9999),The average recovery of psoralen and isopsoralen was 101.17%(RSD=0.96 %) and 99.49% (RSD=1.75%),respectively.Conclusion The method is reliable and accurate.


Pollinator richness, pollination and plant reproduction are analyzed in a fragmentation gradient of the Chaco forests of Córdoba, Argentina. We expect to find direct relationships between pollinator richness, these two processes and the area of the fragments. Considering data obtained by many researchers for different forest sites, the following objectives were planned: i) to evaluate the relationship between fragment area, pollinator richness and Sección especial L GALETTO ET AL. Ecología Austral 17:67-80


e11567 Background: Low-dose metronomic chemotherapy is an emergent treatment schedule in which low doses of cytotoxic agents are given orally continuously, with no or short drug-free intervals. In general it provides better tolerance, especially in patients who have been previously exposed to other oncologic treatments. It is well known that all these low-dose schedules have a favorable safety profile and may provide an adequate tumor control in patients with metastatic breast cancer. However, there are no data in literature reporting the patient´s tolerance and response to subsequent lines of chemotherapy after receiving metronomic regimens. Methods: We retrospectively analyzed 40 patients with metastatic breast cancer treated with low doses of Cyclophosphamide and/or Methotrexate and/or Capecitabine in a single center from June 2009 to April 2014. The following data were collected: age, hormone and epidermal growth factor receptor 2 (HER-2) status, number of lines of chemotherapy prior to and after low-...


Background Arab country revolutions reflect long-term governorate's authority for many years effect on the people. Dissatisfactory feelings about political and economic systems were the main firing of Januray 25 Egyptian Revolution. This dissatisfaction precipitated many psychological symptoms among Egyptian youth, which was expressed as anger. Aim The aim of this study was to identify the impact of January 25 Egyptian Revolution on the behavior and different psychological domains in Assiut University students immediately and 2 years after the revolution. Participants and methods Phase 1 (immediately after the revolution) study was carried out from 1 March 2011 to 30 April 2011 on 3193 students from Assiut University (36.8% males and 63.2% females; 33.8% students from practical vs. 66.2% from academic faculties). Phase 2 (2 years after the revolution) study was carried out from 1 March 2013 to 30 April 2013 on 2914 students from Assiut University (38.9% males vs. 61.1% females; 42.8% students from practical vs. 57.2% from academic faculties). The social, economic, and political parameters were evaluated through standardized questionnaire prepared specifically for this study. The psychological parameters were evaluated using Symptom Checklist-90-R and Scale of Personal Experiences Associated with Emotion of Anger. Results Increased prevalence of all psychiatric symptomatology was recorded among university students immediately after the revolution, particularly paranoia, anxiety, sensitivity, and depression. Although the prevalence of all psychiatric symptoms decreased 2 years after the revolution, hostility and phobia increased. However, the mean scores of all psychiatric symptoms were higher for 2 years than for immediately after revolution, and it was significant for somatization, anxiety, hostility, phobia, paranoia, and psychosis (P<0.001). The prevalence of all psychiatric symptoms was significantly higher among women than men in both phases of the study, except hostility when evaluated immediately after revolution. In contrast, the prevalence of anger was significantly higher among men than women immediately after revolution, whereas the reverse was observed 2 years later. Although the prevalence of anger among studied students decreased slightly, the prevalence of anger triggers, emotional feelings, and behavioral patterns associated with anger increased 2 years after revolution. Moreover, all psychiatric symptoms correlated significantly with nearly all subscales of anger immediately and 2 years after revolution. Conclusion Dissatisfactory feelings about political and economic systems, which were the main firing of 25th January Egyptian Revolution. This precipitated many psychiatric symptoms among Egyptian youth. These psychiatric symptoms, particularly paranoia, anxiety, sensitivity, and depression, led to unacceptance of others. Hostility, anger, rage and lastly expressed in revolution.


Background The ability to give high priority to examinations with pathological findings could be very useful to radiologists with large work lists who wish to first evaluate the most critical studies. A computer-aided detection (CAD) system for identifying chest examinations with abnormalities has therefore been developed. Purpose To evaluate the effectiveness of a CAD system on report turnaround times of chest examinations with abnormalities. Material and Methods The CAD system was designed to automatically mark chest examinations with possible abnormalities in the work list of radiologists interpreting chest examinations. The system evaluation was performed in two phases: two radiologists interpreted the chest examinations without CAD in phase 1 and with CAD in phase 2. The time information recorded by the radiology information system was then used to calculate the turnaround times. All chest examinations were reviewed by two other radiologists and were divided into normal and abnormal groups. The turnaround times for the examinations with pathological findings with and without the CAD system assistance were compared. Results The sensitivity and specificity of the CAD for chest abnormalities were 0.790 and 0.697, respectively, and use of the CAD system decreased the turnaround time for chest examinations with abnormalities by 44%. Conclusion The turnaround times required for radiologists to identify chest examinations with abnormalities could be reduced by using the CAD system. This system could be useful for radiologists with large work lists who wish to first evaluate the most critical studies.


The structural stability and electronic properties of pristine, hydrogenated and chlorinated VS 2 nanostructures were investigated using density functional theory. The optimization of VS2 nanostructures were carried out successfully with the help of B3LYP/ LanL2DZ basis set. Initially the structural stability was confirmed using formation energy. The electronic properties were discussed in terms of HOMO-LUMO gap, density of state (DOS) spectrum, electron affinity (EA), and ionization potential (IP). The chemical hardness (CH) and chemical potential (CP) of VS2 nanostructures are also reported. The results will give the insights on structural stability and electronic properties of hydrogenated and chlorinated VS2 nanostructures.


We demonstrate the first Cs atomic laser operating at 852.1 nm pumped by photoassociating transient Cs-rare gas pairs. This scheme is well suited for high-power diode pumping and indicates that collisional relaxation is not required.


The condensate of 2×300 MW units in Luanhe Power Plant is fully passing through the polishing treatment by using high column separtion technique and ammonex operation.In the debugging process of said units,it was found that a lot of anion resins being mixed up with cation resins as they are transferred through resin separation column,leading to bad effectiveness in regeneration within the mixed bed,and the quality of effluent water can not reach the required standard,being unable to realize the ammonex operation.For this,an approach to said problem has been made,and the feasible solutions being compared,finally,an operation method being adopted as follows:eliminating the upper intaking water of said resin separation column,only maintaining the lower intaking water in service,at the same time,the air valve of said separation column is being opened.After improvement of the operation mode,the phenominon of anion resins mixed up with cation resins has been eradicated,ensuring good regeneration of resins,lengthening the operation period of the mixed bed,improving the quality of effluent water,saving acid and alkali used for regeneration,creating good conditions for safe,high efficient,and ammonex operation of the condensate polishing treatment.


Our purpose in undertaking this work is threefold: to establish trustworthy criteria for the normal electrocardiogram of the child, to determine how and to what extent the child's electrocardiogram deviates from the normal in the various types of heart disease (part II) and to compare the measurements of the child with those of the adult, for which accurate criteria are available. REVIEW OF THE LITERATURE The first electrocardiographic study of children was made by Nicolai and Funaro, 1 in 1908. They recorded the standard lead I for 45 infants and children and noticed the frequent occurrence of a deep S wave in this lead. This finding they ascribed either to hypertrophy of the left ventricle or to a more transverse position of the infant's heart than of the adult's heart. However, they failed to mention whether all the children studied were normal. The same finding of a deep S wave


The effects of lead and cadmium on the growth of Sesbania aculeata and of uranium on the growth of S. aculeata, S. rostrata and its photoperiod insensitive mutant, TSR-1 were studied in a hydroponic set up under controlled conditions. The concentrations of lead and uranium did not affect plant growth. The plants were relatively more sensitive to cadmium. The concentration of all the three heavy metals was highest in the roots but the translocation to the shoot was negligible. Uranium in the nutrient solution did not affect stem nodulation in S. rostrata and TSR-1.


Stocks are one of the key factors ensuring the constancy and continuity of reproduction. In this regard, their internal control serves as the most important element of enterprise management and ensures stable and secure financial and economic activities. The purpose of the study is to improve the methodological support of internal control of the availability and safety of stocks to prevent distortions and illegal actions in terms of their movement, to ensure the reliability of information in accounting, operational and management accounting. To prove the effectiveness of accounting and analytical support for controlling the acquisition, storage, write-off of inventories, it is advisable to use the working document "Test for assessing the inventory accounting system", which contains topical issues that allow assessing the effectiveness of organizing inventory accounting at the enterprise. The working document of internal control, proposed in the framework of the study, "The program of internal control of the availability and safety of stocks", includes a list of control areas, a regulatory framework and sources of information, determines the nature of the audit and control procedures that are necessary to achieve the goal and practical solution of the audit tasks. The working document of internal control "Questionnaire for checking the state of storage facilities and safety of stocks" contains questions that allow the internal controller to fully assess the conditions of storage of stocks, the state of fire safety of warehouses, the equipment of warehouses with equipment, machinery, instruments and the correctness of their operation, the state of security warehouse premises. At the same time, the controller has the ability to clarify and concretize the options for answering the questions posed in the working document. This, in turn, will allow, based on the results of the audit, to provide the manager with all the information necessary for making effective management decisions


Dissertation in its preamble introduces to reader glass evolution since the beginning, which are connected with oldest cultures, it charts development of glass in middle ages, ends with glass nowadays. Second part of the dissertation is concentrating itself on typology of drinking glasses and glass objects normally used in today's dining. Text's are followed with pictorial part, which fills and illustrates information in dissertation included.


The role of electrode-inert metal ions (Zr(IV), Hf(IV), La(III), Mg(II), Ca(II), Sr(II), Ba(II) and Li(I)) in electrochemical reduction of nitrate ion is discussed an the basis of polarographic measurement. No evidence for nitrate-metal ion complexes in the bulk solution was found from UV and Roman spectra under our experimental conditions. No large differential capacity (no double-layer effect) which might be assigned to strong adsorption was observed for all the metal ion solutions. However, our results indicated that the metal ion acted as an intermediary far the charge transfer from the electrode to the nitrate ion and as a proton supplier to the nitrate by the hydrolysis of the metal ion itself in the proximity of the electrode.


The high consumption of fossil fuels has significant environmental implications. An alternative to reduce the use of fossil fuels and develop ecological and economic processes is the bio-refinery approach. In the present study, the authors present the production of biodiesel from castor plants through a biorefinery approach. The process includes sub-processes associated with the integral use of castor plants, such as biodiesel production, oil extraction, fertilizer, and solid biomass production. Economic analyses show that producing only biodiesel is not feasible, but economic indicators (NPV, IRR, and profitability index) show it is much more feasible to establish businesses for the valorization of products and subproducts of castor plants, such as biomass densification. The internal rate return for the second scenario (E2) was 568%, whereas, for the first scenario (E1), it was not possible to obtain a return on investment.


Design researchers are increasingly interested in techniques that support creative teams in various design processes. The methods developed for sharing knowledge and generating solutions are mostly focusing on adults. Creative collaboration with and among children have a specific set of challenges to be considered. In this paper, we describe two design experiments that were conducted with children aged 7 to 9, to explore the applications of co-design methods with children. In those experiments, we observed that children are capable of utilizing make tools but have challenges in group dynamics and reflecting everyday experiences into design ideas.


The paper deals with the relation of power established by narrative texts, exploring the many-sided field of articulation among the related subjects: the narrator as a subject of power, the text as a rhetorical device, and the reader as an ultimate guarantor of meaning. After a brief introduction on the "rebirth of rhetoric" in the second half of the Twentieth century, drawing attention to its links with Reader-response criticism, the paper  focuses on the "power of words" and analyzes three case-studies: Lolita by Vladimir Nabokov (1955), Money by Martin Amis (1984) and The Kindly Ones by Jonathan Littell (2006). These novels depend for their rhetorical effect on the invention of a special narrating voice and on the relationship that it establishes with the reader – an odd mixture of antagonism and complicity, seduction and persuasion. The reader is thus invoked as a brother , but an ambiguous and untrustworthy one, as archetypally described in last verse of the opening poem from Baudelaire's Les Fleurs du mal : « hypocrite lecteur – mon semblable, mon frere ».


We discuss ultracompact stellar objects which have multiple necks in their optical geometry. There are in fact physically reasonable equations of state for which the number of necks can be arbitrarily large. The proofs of these statements rely on a recent regularized formulation of the field equations for static spherically symmetric models due to Nilsson and Uggla. We discuss in particular the equation of state p = ρ - ρs which plays a central role in this context.


We investigate the leading SUSY-QCD contributions to the branch ratio(BR)oft→ch^0 within the context of the minimal supersymmetric standard model(MSSM) with coplex parameters,assuming more generally that there is a misalignment between the squark and quark that leads to a flavor non-diagonal squark mass matrix.We introduce complex phases only in μ and At,namelyФμ and ФAq,for simplicity,and study the dependence of the BRoft→ch^0on these phase parameters.Our calculations show that these CP-violation phases and the flavor mixing parameter λinfluence the BR oft→ch^0 considerably,and the effect induced by ФAt is much larger than that byФμ and ФAc1u.For diffrent values of the complex parameters μand At that are set in this paper,the BR oft→ch^0is in the range of 10^-7—10^-6,depending mainly on the value of the trilinear coupling At


— The derivation of numerical methods to deal with real life problems framed into differential equations has been on the increase of which good attention is directed to Runge-Kutta methods. Recently, researchers have explored the derivation of Runge-Kutta methods by introducing higher order derivative 𝐟 ′ (up to the second order) in the Runge-Kutta 𝐤 𝐢 terms (𝐢 > 𝟏) in order to increase the order of accuracy of the solution to the differential equation. However, this paper presents some new higher order derivative Runge-Kutta methods by using other types of 'mean' such as harmonic mean, geometric mean or harmonic mean as against the conventional Arithmetic mean viewed higher order derivative Runge-Kutta methods. The qualitative features such as the local truncation error, consistency, convergence and stability of the new methods are investigated and established. Numerical examples are used to compare the accuracies of these methods. The results show better performance of some of the derived methods when compared with existing methods.


A possibility of employing the direct contact heat transfer concept for the evaporation of LNG using sea water has been investigated. Observations are made on the physical phenomena and operational characteristics of a spray column type direct contact heat exchanger(DCHX). It is found that a DCHX could playa successful role as an evaporator utilizing sea water without any undue difficulties.


Early during the formation and growth of a primary epithelial tumor, cells disseminate through the bloodstream to distant organs. These circulating tumor cells (CTCs) can be enriched and detected via different technologies and CTC analyses are considered as a real-time "liquid biopsy" in cancer patients. This biopsy allows the characterization of specific sub-populations of CTCs and may revolutionize cancer detection and management. This editorial highlights the current strategies used for enrichment and detection of CTCs. CTC detection holds great promise, and many exciting technologies have been developed over the past years. However, detecting CTCs remains technically very challenging. As CTCs occur at very low concentrations (1 CTC in the background of millions of normal hematopoietic cells), their identification and characterization require extremely sensitive and specific analytical methods, which are usually a combination of enrichment and detection procedures (1). CTC enrichment includes a large panel of technologies based on the different properties of CTCs that distinguish them from the surrounding normal blood cells, including physical properties (size, density, electric charges, deformability) and biological properties (surface protein expression, mostly EpCAM expression). To increase the yield of CTCs, new technologies based on the combination of different CTC properties have been even developed. After enrichment, the CTC fraction usually still contains a substantial number of leukocytes, and CTCs need to be, therefore, identified by a method that can distinguish tumor cells from normal blood cells at the single cell level. Among the protein-based strategies, the CellSearch® system (FDA-USA cleared) and many other CTC assays use the same identification step: cells are fluorescently stained for cytokeratins (CK; positive marker), the common leukocyte antigen CD45 (negative marker), and a nuclear dye (DAPI); CTCs are identified as CK + /CD45 − /DAPI + cells. One key question is


Objective: Gamma knife surgery is an important therapeutic strategy for treatment of a non-functioning pituitary adenoma, as it suppresses tumor growth. However, in rare cases, the lesion may unexpectedly re-grow after gamma knife surgery. This report presents such rare cases of late recurrence of sellar lesions. Case Description: Two cases of non-functioning pituitary adenomas underwent gamma knife surgery. Tumor re-growth occurred following radiation therapy in case 1 at 6 years after gamma knife surgery, while expanding radiation necrosis from the irradiated tumor appeared in case 2 at 8 years after gamma knife surgery. The cases required additional radical removal of the expanding lesion with endoscopic trans-sphenoidal surgery, resulting in successful total removal. Conclusion: A patient with a non-functioning pituitary adenoma should be carefully followed for a long period, even after undergoing gamma knife surgery, to examine for lesion re-growth. In such a case, it is important that the removal operation should be considered immediately to release the compression.


This study investigates the construction of identity that emerges in the consumers' discursive production of a conciliation hearing in a kind of Brazilian Small Claim Court (Juizado especial de relacoes de Consumo) in Minas Gerais state. Based on theories of interactional Sociolinguistic and on Conversation analyses techniques, we recorded four conciliation hearings and analyzed the identity construction of the consumer through their accounts. The data analysis confirmed the richness of identity construction in the narratives we analyzed. We perceived that consumers construct their identities in order to align themselves in the role of victim and align their opponent in the role of villain. For that, the most used strategies are: the exploration of a great number of repetition, the use of extreme terms, and the incorporation of different identity categories.


So far, Body Mass Index (BMI) is used as a measuring tool to assess a person's nutritional status. If there are two who have the same weight and height, they may have different nutritional status. Anthropometric measuring tools play a very important role in determining the nutritional status. The anthropometric guidelines for determining nutritional status are the parameters chosen and recommended, which include an assessment of age, weight, body length or height. On the other hand, technological developments are currently increasing and giving a great influence in almost every sector of life and the state. The process of globalization that occurs in every country in the world today also supports the development and use of technology. The need for information will increase along with the development of technology. Several methods are used to process large data to find the patterns contained in them, including the C4.5 Algorithm and the Naïve Bayes Classification Algorithm which are algorithms from the decision tree method and Bayes theorem. The C4.5 and NBC algorithms will be used for the classification of the nutritional status of children under five, which will be classified into five classes, namely normal, fat, very fat, thin, or very thin.


The effect of the rotational speed and axial torque on the diagnostics of tapered rolling element bearing defects was investigated. The accelerometer was mounted on the bearing housing and connected to Sound and Vibration Analyzer (SVAN 958) and was used to measure the accelerations from the bearing housing. The data obtained from the bearing was processed to detect damage of the bearing using statistical tools and the results were subsequently analyzed to see if bearing damage had been captured. From this study it can be seen that damage is more evident when the bearing is loaded. Also, at the incipient stage of damage the crest factor and kurtosis values are high but as time progresses the crest factors and kurtosis values decrease whereas the peak and RMS values are low at the incipient stage but increase with damage. Keywords—crest factor, damage detection, kurtosis, RMS, tapered roller bearing.


As emotions do play central role in the life of an individual, one is expected to have higher emotional maturity in order to lead a effective life. It is also true that our behaviour is constantly influenced by the emotional maturity level that we possess. Especially, the adolescents who are observed to be highly emotional in their dealings need to be studied. Emotions are great motivating forces throughout the span of human life; affecting aspirations, actions and thoughts of an individual. Adolescents is a period when the behaviour getting influenced highly by the emotions. Emotional maturity can be understood in terms of ability of self control which in turn is result of thinking and learning. People with achievement motives are motivated by standards of excellence, delineated roles and responsibilities and concrete, timely feedback. And the power motive is activated when people are allowed to have an impact, impress those in power, or beat competitors. The present study objective is to study the Impact of Working and Non-working Mothers on the Emotional Maturity and Achievement Motivation of Adolescents.For this research, 60 adolescents (30 adolescents of working mothers and 30 adolescents of non-working) from the age range of 12 to 17 years were randomly selected from the public schools of Delhi and NCR Region.The results reported no significant difference between emotional maturity and achievement motivation of adolescents of working and non-working mothers and no gender difference was also found between the two. The study provides further research across other sections of society to uncover the possible differences or similarities that may be present.


The article,through comprehensive analyzation of all sorts of mathematical descriptions and combining the chracteristics of sports training and its application,introduces the completely new idea——the mobile average and K-line in order for instructors to know the athletes' functional changes,adjust their sports traning and achieve perfect training result.


This symposium was held during the 2023 European Respiratory Society (ERS) International Congress in Milan, Italy. The main objective was to discuss unmet needs in the diagnosis and management of rare lung diseases, with a particular emphasis on alpha 1 antitrypsin deficiency (AATD) and idiopathic pulmonary fibrosis (IPF). Presentations focused on promising approaches to meet these needs, including the feasibility of genomic diagnosis, the development of improved biomarkers of disease progression, such as quantitative CT and novel blood biomarkers, the use of digital lung auscultation, and increased screening for AATD in vulnerable populations.

The overarching message from the symposium was that advancements in technology, multidisciplinary collaboration, and partnerships between academic institutions, patient associations, and industry are crucial to the continued improvement of patient management in rare diseases, and that the education of healthcare professionals is vital to enhance the understanding and awareness of these conditions.


Intelligent Transportation Systems (ITS) utilises the growing trend of both communication technologies and intelligent analytics to make transportation systems more smart and efficient. Federated Learning, a privacy-preserving machine learning paradigm shows promise in being applied in this field. However, the data and device heterogeneity, and highly dynamic environment in ITS pose challenges to the performance of federated learning. One of the recent approaches to address the challenges are to choose proper participants from available clients during training. However, this research field is not fully investigated yet, and many works are still based on the classic random-based selection scheme. In this paper, we present Newt, an enhanced federated learning approach. On one hand, it includes a new client selection utility that explores the trade-off between accuracy performance in each round and system progress. On the other hand, it highlights a feedback control on the selector. Specifically, we implement a control on the selection frequency as a new dimension of client selection method design. We evaluate the proposed system with DNN training tasks on large scale FEMNIST-based datasets that are of different heterogeneity properties. The experiments show that our method outperforms the other baseline methods by as large as 20%.


ABSTRACT This conceptual article uses new materialism, and its particular focus on material things, as a lens of analysis in social studies education in order to demonstrate alternative ways in which social studies education researchers and teachers might engage in inquiry. Historically, social studies curriculum and teaching have centered human agency and its domination of the material, natural world. However, this article argues that an attendance to things, and to the relational-material entanglements we find ourselves in, might guide us toward a reconsideration of how particular ideals and concepts are (and ought to be) represented in social studies curriculum, teaching, and learning. This article models how social studies analyses of material things in past and current events might take shape, exploring how natural things like Hurricane Maria and COVID-19, as well as human-made things like statues, parks, and textbooks, are both agentic and capable of impacting—diminishing or enhancing—the agency of human beings. We discuss how social studies teachers and teacher educators might enact such a focus in their classrooms, offering examples of how natural and human-made things might be integrated into social studies curriculum and teaching.


This editorial refers to 'Associations between single and multiple cardiometabolic disease and cognitive abilities in 14 129 UK Biobank participants', by D. Lyall et al. doi:10.1093/eurheartj/ehw528.

The Ebers papyrus dating back to ∼1550 BC contains a treatise on the heart where it refers to this organ as the centre of the body's blood supply.1 Although blood circulation was not described in this ancient document, diseases such as depression and dementia are discussed as well as their possible treatments. It is anybody's guess whether early Egyptian physicians suspected that the heart could have a role in mental disorders.

Scrolling forward to 1977, an anonymous editor at The Lancet proposed that cardiac dysrhythmia and hypotension in the elderly could be an underdiagnosed cause of cognitive decline and dementia.2 This provocative Editorial was promptly ignored by most readers and unceremoniously shot down by Emerson and colleagues3 in 1981 when they reported no association between cardiac disease and dementia. Except for atrial fibrillation where only four patients from each group were studied, these authors did not examine dyscognitive patients with the cardiac abnormalities listed in Figure 1 , nor did they compare the demented patients with a cognitively intact control group.

Figure 1
Selected cardiovascular and cardiometabolic risk factors reported to impact the brain and induce cognitive dysfunction. These risk factors are …


Human cystathionine β-synthase is a pyridoxal 5′-phosphate enzyme containing a heme binding domain and anS-adenosyl-l-methionine regulatory site. We have investigated by single crystal microspectrophotometry the functional properties of a mutant lacking theS-adenosylmethionine binding domain. Polarized absorption spectra indicate that oxidized and reduced hemes are reversibly formed. Exposure of the reduced form of enzyme crystals to carbon monoxide led to the complete release of the heme moiety. This process, which takes place reversibly and without apparent crystal damage, facilitates the preparation of a heme-free human enzyme. The heme-free enzyme crystals exhibited polarized absorption spectra typical of a pyridoxal 5′-phosphate-dependent protein. The exposure of these crystals to increasing concentrations of the natural substratel-serine readily led to the formation of the key catalytic intermediate α-aminoacrylate. The dissociation constant ofl-serine was found to be 6 mm, close to that determined in solution. The amount of the α-aminoacrylate Schiff base formed in the presence of l-serine was pH independent between 6 and 9. However, the rate of the disappearance of the α-aminoacrylate, likely forming pyruvate and ammonia, was found to increase at pH values higher than 8. Finally, in the presence of homocysteine the α-aminoacrylate-enzyme absorption band readily disappears with the concomitant formation of the absorption band of the internal aldimine, indicating that cystathionine β-synthase crystals catalyze both β-elimination and β-replacement reactions. Taken together, these findings demonstrate that the heme moiety is not directly involved in the condensation reaction catalyzed by cystathionine β-synthase.


This paper provides a status report and initial results of a simulation study that is under way to characterize the expected performance of HF subnetworks using the 'third generation' HF link establishment protocols defined in U.S. MIL-STD-188-141B Appendix C. To begin, a discussion of the necessity of network simulation is provided. This is followed by an overview of the simulation framework used in this study. This overview concentrates on the physical layer models used to model waveform performance in the presence of ionospheric propagation effects and interference, and also describes the implementations of the link establishment and other protocols modeled within this framework. Initial results quantifying the message delivery performance of an example HF subnetwork are presented. Finally, a brief description of future work is provided.


Objective To discuss the influencing facts of the outcome of different surgical treatment of male traumatic urethral stricture.Methods The maiden therapy effects of 237 cases of traumatic urethral stricture of multi-center were reviewed and tested by Log-rank and Chi-square test and partitions of χ2.Results The length of the stricture was divided into two groups.In grpup 1,the length was 0-2 cm,but in group2 the length was 2-4 cm.The recurrence rate in group 2 was significantly higher than that in group1(P0.05).The recurrence rate in patients with perioperative urinary infection was significantly higher than that in patients without perioperative urinary infection(P0.05).In maiden therapy methods of stricture,The recurrence rate in patients with urethral dilatation was significantly higher than that in patients with anastomotic urethroplasty(P0.01),but no significance between urethral dilatation and internal urethrotomy(P0.05).And the recurrence rate in patients with internal urethrotomy was significantly higher than that in patients with anastomotic urethroplasty(P0.01).Conclusions The length of the stricture,perioperative urinary infection and maiden therapy methods of stricture are all important factors of the recurrence of urethral stricture;The incidence of urethral stricture recurrence is relation to the length of the stricture after urethrotomy.If the length of the stricture shorter than 2cm the incidence of urethral stricture recurrence is low,in contrast,if the length longer than 2cm the incidence is high;After anastomotic urethroplasty the incidence of urethral stricture recurrence is relation to perioperative urinary infection and operation,but is not relation to length of the stricture,site of stricture and previous stricture treatment.Compared with other surgical treatment,the incidence of urethral stricture recurrence of anastomotic urethroplasty is the lowest.


Dendroclimatology and Dendrochronology which estimate past climatic environments by examination of annual rings began in America in the early 20th century, but are now being studied in many countries. The tree-ring analysis method by Fritts(1976) especialy contributed much to Dendrochronology by analyzing past climate on the basis of treerang widths. Tree-ring analysis has an important role as an index of environmental pollution(Ohta, 1978; Thompson, 1981; Innes & Cook, 1989). In particular, heavy metals in tree-rings become a very important index for grasping the influence of environmental pollution of the past. Growth of tree-rings was disturbed by Cd, Zn and Pb discharged in a refinery (Suzuki, 1975). Heavy metal pollution of trees was studied by analyzing Ca and Mg in tree-rings(Fukuoka & Kishi, 1995) and Cd, Pb, Zn, Cu and Mn in leaves of street trees(Tatsumi, 1973). By an analysis of heavy metals in tree-ring, the history of heavy metal pollution is demonstrated(Suzuki, 1981 ; Satake et al, 1996), and can used as an index of environmental changes(Meisch et al, 1986). This study investigated heavy metals in tree-rings of trees grown in industrial and non-industrial areas, and compared the concentration of heavy metals, and inquired in to the rel ation between them and tree-ring growth.


and that much of the harvest is processed into food by farm animals. The task of which I speak is that of bringing about a more general understanding of our place in human affairs in order that ours may be properly appraised among the learned professions and thereby strengthen the efficiency of veterinary medicine. Concentrating our devotion to the sick animal without cultivating a clear conception of our basic creed leaves us striving in vain to uplift ourselves above the rating of the "animal doctor." In the 1760's, when the legions of Louis XV were hard pressed for subsistence, formal veterinary education was launched; in the 1860's, while a civil war was ravaging the resources of North America, Andrew Smith came out of Scotland and founded this institution; in 1884, the United States Bureau of Animal Industry was created to cope with a destructive cattle plague, and veterinary colleges began to spring up all over the country; in the 1930's, in his preparation for war, Adolph Hitler put a veterinarian at the head of German agriculture; in 1940, when Germany defeated France, the French veterinarians were kept on the job; in the last three years, five new veterinary colleges were established in thatmany states; animal research laboratories have become a vital necessity; and to-day we are dedicating a fine veterinary college building to the service of Canada. I wonder how much we realize that all of this advancement sprang from wartime food crises which gave visual prominence to man's dependence upon scientific animal production. The contention of these hastily spoken remarks is that despite food crises, man has yet to learn that this civilization, like that of the primitive inhabitants, would not have developed nor long endured without a managed animal industry.


− Dynamic forces realised by accelerated load masses are traceable to acceleration and mass according to the force definition. For the extension of the dynamic force range a new facility based on an electrodynamic shaker system is developed.


Many different carbon materials are developed for diverse applications for industrial and scientific uses. It is known that the amount of hydrogen retained in carbon materials under plasma irradiation strongly depends on the structural characteristics of the material, such as grain size. To clarify the cause of the difference in the amount of hydrogen retained in different carbon materials, hydrogen atom injection into polycrystalline graphite is investigated on the atomic scale by a hybrid simulation technique consisting of binary-collision-approximation-based simulation and molecular dynamics simulation. Then, the incident energy and grain size dependences of the penetration profile of incident hydrogen atoms are carefully investigated.


Horizon line (or sea line) detection (HLD) is a critical component in multiple marine autonomous navigation tasks, such as identifying the navigation area (i.e., the sea), obstacle detection and geo-localization, and digital video stabilization. A recent survey highlighted several weaknesses of such detectors, particularly on sea conditions lacking from the most extensive dataset currently used by HLD researchers. Experimental validation of more robust HLDs involves collecting an extensive set of these lacking sea conditions and annotating each collected image with the correct position and orientation of the horizon line. The annotation task is daunting without a proper tool. Therefore, we present the first public annotation software with tailored features to make the sea line annotation process fast and easy. The software is available at: https://drive.google.com/drive/folders/1c0ZmvYDckuQCPIWfh_70P7E1A_DWlIvF?usp=sharing


The present invention relates to improvements in compositions containing peptides that are ligands of one or more of the melanocortin receptors (MC-R), or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and method of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2 which is a ligand of the melanocortin receptor subtype 4 (MC4-R), and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms a depot at physiological pH that is slowly dissolved and released into the body fluid and bloodstream. The present invention may further comprise an organic component such as dimethylacetamide (DMA) or polyethylene glycol (PEG) with an average molecular weight of lower than 1000.


Prospective two year study period, from 1st August, 2008 to 31st July, 2010, a total of 1,374 autopsies were performed at the centre, 70 cases were suspected cases or confirmed poisoning and those persons declared dead on arrival in the causality and suspected to be a case of poisoning. Incidence of deaths due to poisoning was 5.09 %.Peak incidence was observed in the age group of 21-30 years. Male to female ratio was 2.33:1. Insecticide was commonest poison (22 or 31.42%),followed by alcohol intoxication (16 or 22.85%). Maximum deaths were due to cerebral edema 18(30.50%) cases including insecticide and alcohol poisoning.


This paper will discuss a performative approach to teaching textual analysis on a Musical Theatre course. Students work in investigative teams analysing texts, exploring the context, and finally performing their work. The essence of this approach is the dialogical intra and inter-action between the teams and the tutor. This continuing dialogue stimulates exploration, learning and reflection. The nature of the interaction with the tutor evolves throughout the process as the tutor empowers the groups to work confidently and autonomously.

This critical approach begins by focussing on the performative power of the text while examining the rhetorical context and textual features, driving the action towards a performable goal. These performatives are then contextualised within the greater context of the world today. In this approach, students first investigate their "accepted" context, before being tasked with creating their "new" context, aligning the text with the present, associating it with the realm in which they live. Through the dialogical process of discovery, they explore alternatives to casting, gender, society, and place. The approach then returns to the performative function of the text, focussing on the performability of their analysis. Students' evidence their work by the staging and presentation of it as a performance.


Steel frame and energy-saving composite panel can be connected in specified arrangements to form a coordinating structural system,which has the good property of lateral resistance.In order to study different effects of lateral resistance and hysteresis characteristic between two arrangements,two full-scale models with a conducting low-cycle reciprocating loading test were designed,which were called beam connection and column connection.It was proved that both systems could effectively improve the ultimate bearing capacity and lateral stiffness.Compared with the beam connection,the column connection showed a better ductility,energy dissipation,structural integrity and reliability.In addition,the column connection could give better seismic performance than the beam connection.


Imaging of the Pancreas - Cystic and Rare Tumors. Edited by C. Procacci and A. J. Megibow. Springer-Verlag 2003. ISBN 3-540-42742-2. Price: EUR 139.95 Emergency Radiology. Rules and Tools. Edited by Jane Young. Remedica 2003. ISBN 1-901346-28-5. Price: EUR 40. Imaging in Paediatric Urology. Edited by W. Becker, J. Meller, H. Zappel, A. Leenen and F. Seseke. Springer-Verlag 2003. ISBN 3-540-43348-1. Price hardcover EUR 145,55. Imaging in Stroke. Edited by M. G. Henerici. Remedica publishing limited 2003. ISBN 0-387-95454-6. 216 pages with 75 figures and 8 tables. Price: EUR 45. Imaging of the Foot and Ankle. Techniques and Applications. By A. M. Davies, R. W. Whietehouse and J. P. R. Jenkins. Springer-Verlag 2002. Price: EUR 159. Radiology of the Postoperative GI Tract. By B. R. Javors and E. L. Wolf. Springer-Verlag 2003. ISBN 0-387-95200-4. Price: US$ 159. Imaging-Guided Interventional Breast Techniques. Edited by D. David Dershaw. Springer-Verlag 2003. ISBN 0-387-95454-6. 212 pages, 304 figures. Price Hardcover: EUR 139.


The development of fully flexible sensors for the next generation of wearable electronics are urgently needed, and hydrogel-based flexible sensors are highly sought due to their unique mechanical performances. However,...


SKF has acquired 100% of the shares of Economos Austria GmbH from Salzer Holding GmbH. Economos is an Austrian industrial seals company manufacturing hydraulic and pneumatic seals for the oil and gas, food and beverage, pulp and paper, mining and steel industries. Economos's sales for the year 2005 were close to 70 million Euros and the number of employees was 805. SKF pays 67 million euros on a cash and debt free basis for the company. Economos has a global presence, with Western Europe being its main market. The company is headquartered in Judenburg in Austria. Economos operates through more than 20 subsidiaries around the world and its extensive distributor network. Economos sealing and engineering plastics solutions will strengthen SKF's market position in industrial seals.


The invention discloses a rear suspension system for a rear-drive off-road vehicle. The rear suspension system comprises a spiral spring, a shock absorber, an upper thrust rod, a lower thrust rod and a transverse thrust rod, wherein the upper thrust rod comprises a left upper thrust rod and a right upper thrust rod; the lower thrust rod comprises a left lower thrust rod and a right lower thrust rod; the left upper thrust rod and the right upper thrust rod are arranged on the outer side of a frame of the vehicle; one ends of the left upper thrust rod and the right upper thrust rod are connected to a longitudinal beam of the frame, and the other ends of the left upper thrust rod and the right upper thrust rod are connected to a rear axle; the left lower thrust rod and the right lower thrust rod are arranged at the bottom of the frame; and one ends of the left lower thrust rod and the right lower thrust rod are connected to the bottom of the longitudinal beam of the frame, and the other ends of the left lower thrust rod and the right lower thrust rod are connected to the rear axle. Compared with the prior art, the rear suspension system has the advantages that due to the arrangement, the available space of the inner side of the frame is enlarged, so that the vehicle has a large available body space; and the rear suspension system has high comfort degree, high maneuverability and high safety and reliability.


The traditional methods of disinfection of documents damaged by microorganisms in Russia were fumigation with formaldehyde and thymol. The mass fumigation in the storage area in the Library of Russian Academy of Science after the fire in 1988 has no analogy in the world practice. Approximately 8.1 million books and newspapers, files and stored items with a total volume over 44,000 cube meters were treated. This report presents the results of investigation into documents and storage environment after disinfection with chemical biocides. The paper of disinfected books, dust and air in storage facilities were investigated. Chemical analysis of paper shows that formaldehyde and thymol are still identified in disinfected books. Formaldehyde was also found in the air of storage facilities in high concentration. More than 50 substances were identified in dust, including polyaromatic compounds, polychlorinated biphenils and insecticides such as DDT. Fungal growth took place on the paper of some documents containing formaldehyde. The results of our research prove that all chemical biocides affect the storage environment. Environmental and biological monitoring is gaining a special importance after disinfection. The development of non-chemical methods of disinfection is necessary for conservation. The treatment of biodeteriorated objects in magnetic fields as shown by our laboratory research is a prospective alterntive method.


Durability of simulated high-level waste glass in continuously-flow J-13 tuff groundwater has been examined at 90 C under gamma-irradiation. The results obtained are compared with those without gamma-irradiation. The effects of groundwater radiolysis on the glass durability are discussed based on the Eh-pH excursion obtained in the present system. It is found that the groundwater tends to be reduced under gamma-irradiation, however, this may not influence the solubility of multivalent cations leached from the glass.


Abstract Let A be a finite dimensional associative K-algebra with an identity over an algebraically closed field K, d a natural number, and modA(d) the affine variety of d-dimensional A-modules. The general linear group Gld(K) acts on modA(d) by conjugation, and the orbits correspond to the isomorphism classes of d-dimensional modules. For M and N in modA(d), N is called a degeneration of M, if TV belongs to the closure of the orbit of M. This defines a partial order ≤deg on modA(d). There has been a work [1], [10], [11], [21] connecting ≤deg with other partial orders ≤ext and ≤deg on modA(d) defined in terms of extensions and homomorphisms. In particular, it is known that these partial orders coincide in the case A is representation-finite and its Auslander-Reiten quiver is directed. We study degenerations of modules from the additive categories given by connected components of the Auslander-Reiten quiver of A having oriented cycles. We show that the partial orders ≤ext, ≤deg and < coincide on modules from the additive categories of quasi-tubes [24], and describe minimal degenerations of such modules. Moreover, we show that M ≤deg N does not imply M ≤ext N for some indecomposable modules M and N lying in coils in the sense of [4].


State departments of transportation are benefiting from new tools--like new research and lithium admixtures--now available to identify and fight destructive alkali-silica reactivity (ASR) in portland cement concrete roads and bridges. New guideline specifications released in late 1999 by an ASR Lead States Team may help states deal with ASR. Among other remedies, the model specifications state the lithium compounds are capable of suppressing deleterious ASR and provide guidance for lithium's use. The most widely available lithium-based admixture--LiNX lithium nitrate alkali-silica reactivity inhibitor--is proving its mettle in fighting ASR on a long-term basis. The synergy of new knowledge and new materials will accelerate the fight against ASR in coming years.


An event-driven architecture for master-worker network computing is proposed to meet the needs in large-scale network computing systems such as high-concurrency,dynamic resource control and stability.The architecture combines the advantages of multi-threaded mode and event-driven mode,and a new strategy of thread management that is suited for master-worker network computing is derived based on queuing theory.The introduction of network queue extends the application domain of staged event-driven architecture from single host to wide area network environment,and the use of delay queue improves system response and reliability.The priority queue is designed for effectively supporting a variety of job scheduling mechanisms.Moreover,systems have the characteristics of modular construction and rapid development.Experiment results and the application of drug discovery grid with systems based on the proposed architecture show that the average job submission time is reduced from 1 850 s to 1 350 s and the average job processing time is reduced from 1 910 s to 1 420 s for 1 000 jobs,and that system resources have more rational use.


An ORL (optical return loss) measurement device relates to the field of optical measurement devices. The ORL measurement device comprises a laser source (1), an optical splitter (2), an optical power meter (3) for measuring reflected power, a return loss meter (4) and a return loss meter output interface (5), wherein the laser source (1), the optical splitter (2) and the optical power meter (3) for measuring the reflected power are fixedly arranged on the return loss meter (4); the output ends of the laser source (1) and the optical power meter (3) for measuring the reflected power are connected with the two input ends of the optical splitter (2) respectively; and one output end of the optical splitter (2) is connected with the return loss meter output interface (5). The ORL measurement device can measure both the power of incident light with return loss and the insertion loss. The measurement of the insertion loss and return loss is integrated into a piece of equipment, so that the use is convenient.


Subclinical vitamin B12 (cobalamin) deficiency frequently occurs and over the years numerous clinical symptoms may become apparent [1, 2]. These include neurological and psychological disorders, anaemia, pregnancy complications and miscarriages. However, through early diagnosis and vitamin B12 supplementation, irreversible neurological damage and other health problems can be prevented. Recent studies have shown that additional intake of vitamin B12 along with B6 and folic acid in the form of dietary supplements may protect against age-related diseases [3].


To test different biogeographical scenarios for the evolution of the ground beetles of the Trechus fulvus group, a lineage with many narrowly distributed flightless subterranean species, highly suitable for tracing their biogeographical history.


First-trimester aborted fetuses with abdominal cysts (n=76) have been examined at anatomic-pathological investigation. A final diagnosis included choledochal cyst, duodenal and anorectal atresia, cloacal disgenesis syndrome and megacystis. Besides gastrointestinal atresia and lower urinary tract obstructions heterotaxy and diaphragmatic hernia have been revealed at morphological examination. In total 23,7% of fetal abdominal cysts in the first trimester of gestation were associated with chromosomal abnormalities.


Education is not intended to provide only degrees. It is meant to prepare an individual as a human being as per the need of society and also inculcate skills in them so that they can contribute to the development of society. The 21st century is facing rapid growth in technology, which has impacted every global sector. The emergence of knowledge and information has given major exposure to change in every working sector. To cope with rapid change, we need to adopt new skills, bring necessary change, and upgradation of our knowledge is important. So, the 21st cent skills & competencies inculcation in students is essential to be successful in the 21st-century industry. TPACK is a framework that supports teachers in the planning, implementation, and reflection on their teaching method with appropriate use of their domain of education which is Technology Pedagogy & content knowledge. Life skills talked about the skill which will be the pillar of students' holistic development for their future.


This paper presents an algorithm for automatic facial expressions recognition. The algorithm is based on the Local Binary Patterns (LBP). The proposed algorithm first calculates the horizontal and vertical edges of the input image that gives important information of facial expressions. Facial expressions are generated by movement of muscles that are better represented in the form of edges. Next LBP histograms are extracted from both the edge maps after dividing the edge image into blocks. In addition, in order to reduce the dimensions of LBP histogram only uniform patterns (ULBP) are used, which reduces the computational complexity of facial expressions recognition. The proposed algorithm is tested on standard facial expressions databases TFEID & JAFFE. The experimental result shows that the proposed algorithm can obtain average recognition rate of 80% on TFEID images when using fixed and adaptive weights. In case of JAFFE images, recognition rate is 80% and 74% respectively.


Tomato (Solanum lycopersicum L.) yield in India is below world averages. To increase productivity, it is necessary to develop superior varieties/hybrids. The efficiency of selection depends upon the nature and magnitude of genetic variability and degree of transmissibility of desired characters. Because yield is a complex character, its direct improvement is difficult. Twenty-six genotypes of tomato were assessed to determine the nature and magnitude of variability, correlation, and path coefficient analysis between yield and yield-contributing characters. The analysis of variance (ANOVA) revealed highly significant differences among all genotypes for the characters. The genotype 'EC-357838' had the highest mean value for number of fruit per plant, total soluble solids, and yield per plant. High PC phenotypic coefficient of variability (PCV), genotypic coefficient of variability (GCV), and heritability estimates, coupled with high genetic gain, were observed for plant height, number of fruit per plant, yield per plant, and fruit weight, indicating that these characters are under additive gene effects and more reliable for effective selection. Correlation indicated that yield was significantly and positively associated with number of fruit per plant and per cluster. Path analysis at the genotypic level indicated that fruit weight had the most positive direct effect on yield per plant followed by number of fruit per plant, fruit diameter, and number of fruit per cluster. Direct selection on the basis of fruit weight, number of fruit per plant, fruit diameter, and number of fruit per cluster is reliable for yield improvement in tomato.


Reactor performance currently is being measured primarily by the time operating efficiency. However, the time operating efficiency reveals only a partial picture of the overall reactor performance, since it indicates only the amount of time that the reactor is operating and indicates nothing concerning actual efficiency while operating. True efficiency is measured by the amount of production accomplished with respect to the production potential of the facility. To present a more accurate picture of reactor performance, two types of losses need to be examined in addition to losses resulting from normal outages. These are losses during non-equilibrium operating conditions and differences between plant potential level and the actually achieved equilibrium level. Losses of these types have been reported to the Process Evaluation Group by the reactor Operations Physicists. The purpose of this document is to report the results of an analysis of these data for the period of May through June, 1956, to determine the uses of this type of analysis, and to determine if such data should be collected and analyzed routinely.


There are numerous uranium occurrences in basin fill units of the Maritimes Basin, and in the adjacent crystalline basement rocks in Atlantic Canada. The exploration model applied to the sandstone-hosted uranium occurrences was that of a uranium roll front, similar to the deposits of Texas and the western United States. The recognition of deeply weathered granitoids below the unconformity of the Horton Group on the South Mountain Batholith, however, suggests that a genetic link to regolith-related unconformity deposits, such as the Athabaska Basin of Saskatchewan, may also be applicable. Although there is no doubt of the presence of roll fronts in Horton Group sandstone, the source of uranium within the system may be related to weathered horizons beneath the Horton Group rocks and not exclusively the result of diagenetic change in the sandstone. In the area near Windsor, Nova Scotia, there are numerous uranium occurrences with the most notable being at Three Mile Plains where Saarberg Interplan Canada Ltd. drilled numerous diamonddrill holes from 1978 to 1981. Significant uranium is restricted to the Glass Sand unit of the Horton Bluff Formation and the base of the Cheverie Formation. The uranium occurrences can be divided into two types: (1) carbonand pyriterelated quartz-sandstone type and (2) hematite arkosic-sandstone type. Although this paper deals primarily with uranium and associated elements from occurrences in the Windsor area, the regional nature of the pre-Carboniferous weathering episode and the areal extent of the Horton Group strata throughout eastern Canada would seem to imply that suitable environments for uranium mineralization might have existed throughout the Maritimes Basin. This may be of particular note in areas that have numerous uranium occurrences in granitoid basement rocks adjacent to the Carboniferous basin fill.


Operation of the irrigation network with high efficiency is the main target for water management engineers to improve the water distribution due to the increase water demand. Evaluation of the performance of Egyptian canals is the main objective of this study to improve the canal's operation. Extensive and intensive field measurements have been carried out on five Egyptian canals, which are located in Upper Egypt, Middle Egypt, and Delta, to determine the actual geometrical parameters for the selected cross section. The physical properties for soil and water samples of selected canals were also determined. Various analysis were performed for the collected and measured data to evaluate the canals' performance. It can be concluded that the conveyance efficiency for all selected reaches recorded more than 90% except the canal end. Therefore, the maintenance methods have to be applied regularly to insure passing the required discharges. The operation and maintenance guidelines have to be prepared to asses operators to improve the canals' efficiency.


This study explored the transfer of strategic thinking and self-regulated learning in practice with musicians by observing seven undergraduate music students in practice sessions on both a newly learned instrument and their primary instruments. Students chose how to structure the sessions and were presented with the music, a pencil, and a piano. The timed, recorded practice sessions included a scale and a short, unseen melodic extract. Questionnaire results showed there to be no differences in self-reported goal-orientation, self-satisfaction, global efficacy, or selfefficacy for the two instruments. Although highly individual, both positive and negative observed behaviors such as verbalization, the approach to the material, and even avoidance of certain elements were consistent in both contexts, supporting the transfer of strategies across instruments. This suggests an opportunity for enhancement and acceleration of progress with carefully directed education and conscious application of selfregulation.


During the period of "13 Five-year Plan", in the course of local establishment of application-oriented universities, civil-run colleges have aroused the extensive public attention with vigorous support from government and enterprises, thus making it in line with public colleges for the first time. The transformation development of civil-run colleges cannot be possible without the active adaptation to local innovation-driven strategy and the transfusion of talents, technologies and intellectual supports for the benefit of local economic and social development. Civil-run colleges should change their idea of school running, start with the reform of innovation and entrepreneurship education, enhance the competence of high-level scientific research in satisfying the first-line needs, build a proficient "double-qualified teacher" team, exploit various resources, make full use of their own advantages and characteristics, and establish themselves as high-level application-oriented universities. Keywords—civil-run colleges; application-oriented universities; transformation


This paper devoted to propose a human-machine integrated simulation method to evaluate the effect of corrective maintenance (CM) strategies on manufacturing cells considering the worker's autonomous and collaborative behaviors. First, a human-machine integrated model is developed to integrate the worker behaviors in the CM process by using agent technology. In this way, worker's dynamic and cooperative behaviors can be explicitly modeled and simulated. Then, the collaboration behaviors in the CM process and the measurement of the simulation model are discussed. Third, the proposed simulation model is applied in a motor-cycle engine cell, and a comparative simulation experiment is designed and conducted for two different maintenance strategies. Simulation results show the strategy designed with collaboration behavior performed better during the CM process than maintenance strategy without collaboration behavior. The proposed simulation method can dynamically and quantitatively evaluate the CM strategy optimization, especially when considering worker's collaborative and autonomous behaviors.


This paper discusses a technology for fabricating compact scanning mirrors from magnesium alloys by polishing and diamond microturning. The use of magnesium alloys makes it possible to significantly reduce the mass of the mirrors.


Prevalence surveys of Schistosoma haematobium were carried out in the Koryole and Merca Districts of the Somali Democratic Republic. The examination of urine samples from farmers from many parts of Somalia showed that S. haematobium is endemic in the valleys of the Juba and Shebelli Rivers, southern Somalia. The prevalence rates in the Lower Juba Region (three villages), Koryole and Merca Districts were 65·8%, 48·9% and 60·;7% respectively. Infection rates were high in all age groups in Koryole and Merca. Males had higher infection rates than females. The intensity of S. haematobium infection varied from 12·6 eggs per 10 ml in Koryole and 32·1 in Merca to 238·0 for Lower Juba.


The synthesis of novel N,Nʹ-disubstituted benzoyl thiourea ligand [3,4-dichloro-N-((5-chloropyridin-2-yl)carbamothioyl) benzamide] (L) is achieved in two steps. First step by refluxing KSCN with 3,4-dichloro benzoyl chloride in CH3CN solvent and the other step by the reaction of the resulting filtrate from the first step with 2-amino-5-chloropyridine. The copper(II), Cobalt(II), Nickel(II) and Zinc(II) chloride and acetate salts were coordinated with L ligand in the 1:1 and 1:2 mole ratios (M:L) in the solvent mixture of DMF/H2O or CHCl3/methanol to form the complexes with structural formulas {[LMCl2] and [L2M](CH3COO)2, M= Copper(II), Cobalt(II), Nickel(II) and Zinc(II) ions}. Two mole ratios of the starting materials, 1:1 and 1:2 (M:L) were experimented to form chloride complexes, the product was with structural formula [LMCl2] while acetate complexes with [L2M](CH3COO)2 formula are resulted with the same conditions. Ligand L and its complexes [LCuCl2], [LCoCl2], [LNiCl2], [LZnCl2], [L2Cu](CH3COO)2, [L2Co](CH3COO)2, [L2Ni](CH3COO)2 and [(L)2Zn](CH3COO)2 have been characterized by mass spectrometry, elemental analysis, magnetic moments, conductivity measurements, solubility test, UVvisible, FTIR, H and C NMR spectroscopies. Electrochemical studies were probed by using cyclic voltammetry technique(CV). The data reflect the quasi-reversible reductive nature for the Copper(II) complexes with one electron transfer process while Nickel(II) and Cobalt(II) complexes exhibited two consecutive irreversible reductive nature. The observed UVvisible, elemental analysis, molar conductivity, magnetic moment measurements and solubility test revealed that the metal ion in the all prepared complexes adopted four coordinated square planar structures and [LCuCl2], [LCoCl2], [LNiCl2], [LZnCl2], are formed as neutral complexes while [L2Cu](CH3COO)2, [L2Co](CH3COO)2, [L2Ni](CH3COO)2 and [(L)2Zn](CH3COO)2 adopted anion complexes. The observed magnetic moments show diamagnetic properties of Zinc(II) and Nickel(II) complexes while Copper(II) and Cobalt(II) appeared as paramagnetic species. FT-IR analysis confirmed the coordination sites between the central metal ion with ligand L through two sites, the nitrogen atom in pyridyl ring and the sulphur atom in C=S group.


The linear quadratic Gaussion stochastic optimal control theory and Kalman filter are applied to the semi-active suspension control systems. The conclusion that the r.m.s. of vertical acceleration is decreased with the increasing of the r.m.s. of suspension travel is drawn by the simulations. An adaptive control strategy for off road vehicle semi-active suspension is presented. A LQG control system adapting to road conditions and vehicle speed varying is constructed. The simulations to verify the adaptive control are carried out.


This study examines firms' stock returns' behaviour, when they announce corporate events such as management change, collaborations and stock repurchases. It examines how those events are portrayed in firms' stock returns. The methodologies used are event study analysis and bootstrap. Companies selected belong to eight different sectors of Athens Stock Exchange with different market value in order to get a more general picture that does not only represent one sector which can be influenced individually by accidental factors. The sample constitutes forty firms listed in Athens Stock Exchange. Results indicate that corporate events' impact is important and a key for enterprises to follow new challenges and create financial value. Overall, this paper provides evidence on the impact of corporate governance on stock returns in Greece. The implication is that corporate events create financial value.


Real-time stereographic display of volumetric datasets in radiology. SPIE, Electronic Imaging, 2006 (accepted). Grant application: Optimizing MDCT display for detection and diagnosis of pulmonary embolism. Summated to NIH, June 1, 2005. Real-time stereo projection and display for 3D radiographic data. Submitted to NIH, June 17, 2005. Real-time interactive display for virtual endoscopy. Submitted to NIH, October 19, 2005. CONCLUSIONS Our primary objective is to determine whether a stereoscopic display concept has potential for improving the efficiency and accuracy of chest CT for lung cancer screening. In this progress period, our main tasks were to develop algorithms, software infrastructures and to prepare hardware and study cases, which are all necessary for the study. Mainly, we have investigated and developed algorithms to generate stereo image pairs from volumetric chest CT images. More specifically, we have used combined models of geometric transformation and transparency-contrast for develop; ping compositing methods that were specially tailored to stereo image pairs from l:ung CT images. For preparing the study, a software was developed to include the functionalities needed for the observer performance study. In addition, we have built a display workstation that can stereoscopically display chest CT images in realtime, with mechanisms for various user interactive actions. The important issue we have addressed in this progress period is the optimal rendering methods for nodule detection in lung cancer screening with stereographic display. Choosing a compositing method that is optimal for a particular task, lung nodule in our case, is the key decision in optimizing stereographic displays. Our results indicate that distance-weighted MIP may be a better choice for lung nodule detection in stereo lung CT images for its high local contrast and partial preservation of geometric information, whereas compositing by means of distance-weighted averaging is preferable for nodule characterization. The relative clinical value of these compositing methods will be evaluated in the upcoming data analysis and the main study. REFERENCES 1. Greenlee RT, Murray T, Bolder S, et al. Cancer statistics, 2000. CA Cancer J Clin 2000; 50:7-33. 2. Ries LAC, Elsner MP, Kosary CL, et al. SEER: cancer statistics review, 1973-1997. Bethesda, MD: National Cancer Institute, 2000. 3. van Klaveren RJ, Habbema JDF, Pedersen JH, et al. Lung cancer screening by low-dose spiral computed tomography. Eur Respir J 2001; 18:857-866. 4. Flehinger BJ, Kimmel M, Melamed M. The effect of surgical treatment on survival from early lung cancer. Chest 1992; 101:1013-1018. 5. Sobue T, Suzuki T, Matsuda M, et al. Survival for clinical stage I lung cancer not surgically treated. Comparison between screen-detected and symptom-detected cases. Cancer 1992; 69:685-692. 6. Miettinen OS. Screening for lung cancer. Radiol Clin North Am 2000; 38:479-486. 7. Anderson BL. Stereoscopic surface perception. Neuron 1999; 24:919-928. 8. Anderson BL. The role of occlusion in the perception of depth, lightness, and opacity. Psychol Rev. 2003; 110:785-801. 9. Erickson BJ, Rettmann DW. A method for rapid computation of maximum intensity projection images. J Digit Imaging 1997; 1093 Suppl 1:207-8. 10. Lori E. Dodd , Robert F. Wagner , Samuel G. Armato, III , Michael F. McNitt-Gray , Sergey Beiden , HeangPing Chan , David Gur , Geoffrey McLennan , Charles E. Metz et al. Assessment methodologies and statistical


The paper describes the rationale and 10-day implementation in a 5 th -grade classroom (n=19) of an experimental ratio-and-proportion instructional design. In this constructivist-phenomenological design, coming from our theoretical perspective, design research, and domain analysis, students: (1) link 'real-world' and 'mathematical' objects reciprocally through classroom enactment of word-problem situations vis-a-vis guided reading/writing of spatial-numeric inscriptions; (2) interpret and invent rate, ratio, and proportion texts as patterned cells in and from the multiplication table; (3) revisit and consolidate addition and multiplication as conceptual domain foundations. Students of diverse ethnicity, SES, and mathematical competence engaged successfully in discussing and solving complex problems, outperforming older students on comparison items.


Abstract The purpose of this study was to investigate the goal orientations of nonrevenue producing team student-athletes and sport morality levels. Student-athletes (SAs) (male n=114, female n=118) from a southeastern university, competing in both semicontact and noncontact sports were examined by completing the Task and Ego Orientation Sport Questionnaire (TEOSQ) and the Hahm-Beller Values Choices Inventory (HBVCI). The data were analyzed by utilizing MANOVA and Pearson Correlation analyses. This study attempted to determine whether particular sports were significantly different in either sportsmanship levels or goal orientations. Results, implications, and future recommendations follow.


With annual shoot of'Guanghui'crabapple and'Redlove'apple as a scion,as well as annual seedling of the wild apricot,plum,siberian crabapple as a rootstock,'T'-shape bud grafting and plate budding method was applied,the effect of surviving rate on the time of bud grafting,part selection of scion for'Guanghui'crabapple and'Redlove'apple with bud were studied,and it was expected to reach the highest surviving rate of bud grafting.The results showed that the best time for bud grafting was in the middle of August to early September;central part of annual shoot was appropriately chose,and by which reached high surviving rate;annual seedling of the wild siberian crabapple as a rootstock was used,which was advisable to choose the thickness of 1-2centimeter;'T'-shape bud grafting was priority,which could reach high surviving rate,and if the best time of bud grafting was missed,the plate budding method was applied.


In order to follow and fulfill the development of the times wrapped in technology, every Arabic teacher is also required to be able to master and apply technology in Arabic language learning. In a study conducted by Rustam Shadiev and Mengke Yang, it was found that of the twenty-four articles reviewed on the use of technology in foreign language learning, almost all of these studies reported positive results. Learners had a positive perception of the use of technology, which meant that it showed that technology was effective in supporting language learning and that learners accepted and used it. Based on this, mentoring and training activities to improve teaching competencies for 21 Arabic language teachers in the Puteri Ummul Mukminin Aisyiyah Islamic Boarding School in South Sulawesi were carried out on Saturday, May 27, 2023, with the speaker, Assoc. Prof. Dr. Nurkhamimi Zainuddin from the Faculty of Primary Language Studies, Uniersitas Sains Islam Malaysia (USIM). This is certainly expected to provide additional knowledge about the importance of using technology in Arabic language learning that can be applied both online and offline. The activity was carried out in three stages: preparation, implementation, and reflection.


i Acknowledgements I would like to take this opportunity to acknowledge the invaluable assistance and support given to this author during the course of this project: To my advisors, Steve Colman and Nigel Wattrus for their guidance, instruction, advice, and patience. I joined you almost directly from the battlefields of Iraq, with no geology education to speak of, yet you still gave me this incredible opportunity. You helped to make a potentially difficult transition into something both exciting and unforgettable. for taking the time to share your experience with me and for providing me all the resources, advice, animated discussion, and food for thought I could have asked for. Thank you to my fellow graduate students for your warm welcomes and unconditional support. Good luck to all of you in your future pursuits. A special wish of luck to Emily Voytek, the graduate student to whom I pass the baton on this project. Have fun with those lines outside Thunder Bay. Finally, I wish to thank the captain and crew of the R/V Blue Heron for their unparalleled professionalism. Without your patience and support, this project would have not been possible. ii Abstract Glacial Lake Agassiz was the largest of the North American glacial lakes. Over its 4,000 year existence, Lake Agassiz varied substantially in aerial extent and volume. This variability was a function of the fluctuating retreat pattern of the Laurentide Ice Sheet, differential isostatic rebound of the North American crust, the topography of the land exposed by the retreating ice, and erosion of the various outlet channels draining the lake. These factors combined to form a history of Lake Agassiz punctuated by sudden and sometimes catastrophic rerouting of its drainage from one outlet channel to another. The amount and routing of Lake Agassiz discharge has become controversial. However, extensive onshore observations of Glacial Lake Agassiz discharge features have firmly established that northwestern Lake Superior was a major drainage route following the retreat of the Marquette glacial advance ca. 9,500 years 14C BP. High-resolution, single-channel seismic-reflection data collected with a small airgun were acquired to test the hypothesis that the Post-Marquette drainage event left diagnostic stratigraphic and geomorphic signatures beneath Lake Superior. The unique bathymetry of northwestern Lake Superior, where water depth plunges off Nipigon and Black Bays, makes this location ideal for the characterization of the Post-Marquette depositional and erosional features. The initial, sudden discharge of high-velocity water …


SUMMARY

The floral characteristics (white, salverform, nocturnal sweet fragrance emission) of Isotoma petraea F. Muell. are indicative for pollination by night flying Lepidoptera. The pollen issue is regulated by a valve which has to be operated by the visitor. The valve consists of two connected, dead papillae. The distal parts of these papillae form the trigger hair. A tuft of smaller, also dead papillae under the valve acts as a spring and produces the counter force that repositions the valve after operation. The required force on the trigger hair is 9.5 Dyne. At anthesis the pollen grains are produced inside a closed anther box. Inside this box the piston shaped style gives pressure onto the mass of pollen. On the opening of the valve, this pressure causes the pollen grains to flow out of the box.

A radiant ring of papillae around the style tip acts as a safety valve, that allows the pollen grains to pass if the pressure becomes too high. This happens when the valve is not operated, and the style continues to increase the push forward.

In the genus Isotoma, this mechanism of regulated secondary pollen presentation seems to have evolved by differentiation of brush papillae on the anther tips. The evolution in Asteraceae and in Campanulaceae seems to have developed along convergent lines. Firstly secondary pollen presentation produced spatial exactness. Secondarily, in at least three independent lines, a temporal exactness evolved, presumably under a selection pressure that acted towards a prolonged pollen protection.


This paper describes how legislation in the state of Washington requires that Regional Transportation Plans (RTPs) incorporate a "least cost planning" methodology into updates of those plans after December 31, 1999. The Washington State Department of Transportation (WSDOT) was responsible for providing guidelines on this methodology, one for urban regional transportation planning organizations (RTPOs) and one for rural RTPOs. The Island County Sub-Regional Transportation Plan was chosen as the pilot project for developing the rural methodology. Least cost planning had been around in the energy field for some time, but had only been introduced to the transportation field on a theoretical basis at that time. Least-Cost Planning: Principles, Applications, and Issues2 was selected as the guide for developing the project. This research did not actually provide a methodology, but discussed the concepts of least cost planning within the framework of transportation planning methods. Six principles were identified and became the basis for the study, and these principles are: (1) an emphasis on developing system-level plans, (e.g. regional or MPO level plans) to explore policies that can only be fully evaluated at that level; (2) consideration of all alternatives, including demand management approaches; (3) explicit accounting for uncertainty in the estimation of benefits and costs; (4) public involvement in the decision-making process; (5) coordination among jurisdictions; and (6) monitoring and updating plans to reflect new information about demand for different facilities and the cost-effectiveness of different approaches. This paper describes how those principles were applied to the Island County Sub-RTP, what constraints exist to applying the methodology, and the advantages of using least cost planning.


This chapter presents typical applications and process configurations for both open- and closed-loop pressure retarded osmosis (PRO) systems, summarizing the current state of PRO technology at the pilot and industrial scale, and discussing future perspectives for salinity gradient energy from PRO. The first PRO configuration explored has been river-to-sea water and although this configuration has the potential to be a reliable source of base-load renewable energy, the low-energy density associated with this salinity gradient makes commercialization of PRO in this configuration unlikely. Additional PRO configurations include reverse osmosis (RO)–PRO and osmotic heat engines (OHE). The higher salinity gradient available for power production in RO–PRO systems and energy conversion in OHE is likely to make them a more promising component of an alternative energy portfolio.


Instructional design is a fundamental base for educational technologies as it lays the foundation to facilitate learning and teaching based on pedagogical underpinnings. However, most of the educational technologies today face two core challenges in this context: (i) lack of instructional design as a basis (ii) lack of support for a variety of instructional designs. In order to address these challenges, we propose a patterns based approach for design of educational technologies. This is in contrast with existing literature that focuses either on patterns in education or in software, and not both. The core idea of our approach is to leverage patterns for modeling instructional design knowledge and to connect it with patterns in software architecture. We discuss different categories of patterns in instructional design. We then present the notion of Pattern-Oriented Instructional Design (POID) as a way to model instructional design as a connection of patterns (GoalPattern, ProcessPattern, ContentPattern) and integrate it with Pattern-Oriented Software Architecture (POSA) based on fundamental principles in software engineering. We demonstrate our approach through adult literacy case study (287 million learners, 22 Indian Languages and a variety of instructional designs). The results of our approach (both web and mobile versions) are available at this http URL and were adopted by National Literacy Mission Authority of Government of India.


The study investigates the linear and nonlinear causal linkages between the tax-spend nexus in Nigeria for the periods 1961-1992, 1993-2012 and1961-2012. Employing a nonparametric causality test of Diks and Panchenko (2006) as well as the parametric causality test using the VAR model, results show that there is evidence of uni-directional linear causality from government revenue to government expenditure in the first period and uni-directional nonlinear causality from government revenue to government expenditure in the second and third periods. However, the nonlinear causal relation evidence that government revenue Granger cause government expenditure disappears after the VAR filtering. The policy implication of this result is that government should intensify efforts to improve her revenue accompanied with appropriate fiscal expenditure reforms.


This research aimed to study the effects of different radiations sources in the DNA structure, the irradiations used in this study is Ultraviolet and this is as a stimulation model for the Iraqi environment after the long exposure for different weapons in the repeated wars that happened, and chemical pollutants from car exhaust as well as from factories activities.The white blood cells were exposed to Ultraviolet ray for different time intervals. Also we study the effects of Orignm vulgara fractionation organic extract as a protective method for the destructive effects of irradiations by using DNA fragmentation test.The results showed that short time exposure to Ultraviolet ray for (5, 10, 15 min) at (30, 0 cm) highest have no effect on DNA structure, while the exposure to Ultraviolet ray for (3 hour, 0 cm) produce DNA decay. To counteract this destructive effect of irradiation the Orignm vulgara organic extract was added to the cells suspension before irradiation. Key words: UV Irradiation, DNA fragmentation test, fractionation organic extract.


The optimization study of gold wire bonding process between quartz glass gold-plated electrodes and metal base pins was carried out by partial factorial DOE method. The multiple linear regression equation corresponding to the bond tension value and the influence factor was obtained by regression fitting. The study found that the significant degree of influence of the bonding parameters on the bonding tension value was in the following order: ultrasonic time>bonding pressure>bonding temperature>ultrasonic power. The optimized parameter combination was as follows: the ultrasonic power was 100mW, the ultrasonic time was 25ms, the bonding pressure was 25cN, and the bonding temperature was 150℃. The ultrasonic power had a significant interaction with the bonding temperature. When the bonding temperature was at a low level, the bonding tension value increased with the increase of the ultrasonic power. When the bonding temperature was at a high level, the bond tension value decreased with the increase of the ultrasonic power. After verification, the bonding tension was greatly improved using the optimized bonding process parameters.


Two studies report a positive relationship of employees' perception of being valued and cared about by the organization with (a) conscientiousness in carrying out conventional job responsibilities, expressed affective and calculative involvements in the organization, and (e) innovation on behalf of the organization in the absence of anticipated direct reward or personal recognition. In Study 1, involving six occupations, positive relationships of perceived support with job attendance and perforrnance were found. In Study 2, using manufacturing hourly employees and managers, perceived support was positively related to affective attachment, performance outcome expectancies, and the constructiveness of anonymous suggestions for helping the organization. These results favor the extension and integration of emotion-based and caleulative theories of organizational commitment into a social-exchange approach. The concept of organizational commitment has attracted considerable interest as an attempt to understand the intensity and stability of employee dedication to work organizations. Two major views of employee dedication focus on affective attachment and calculative involvement, respectively, which are usually considered to be conceptually and empirically distinct (McGee & Ford, 1987; Meyer, Paunonen, Gellatly, Gotiin, & Jackson, 1989; Morrow, 1983; Penley & Gould, 1988; Reichers,


SUMMARY
Prostate tumors can develop resistance to androgen receptor (AR)-targeted therapies through treatment-induced changes in transcription factor activity that promote transcriptional and morphologic features of a neuroendocrine lineage. This study identifies an unexpected role for the circadian protein ARNTL in resistance to enzalutamide, a second-generation AR-targeted therapy. See related article by Linder et al., p. 2074 (4).


In the course of the multimedia teaching, there are many psychological problems such as aspects of the interface design ,information and the speed presenting,and student's reciprocation with multimedia teaching .These factors have important influence on student's learning effects.


Objective
To explore the choices and timing of different treatment regimens of prostate cancer.

Methods
The complete clinical data of one case of localized high-risk prostate cancer was reported. The patient, aged 69 years old, was admitted to hospital with urinary frequency and dysuria for 2 years. Serum total PSA was 36.8ng/ml and prostate biopsy dignosed as prostate cancer. The Gleason score was 4+ 3, and the clinical stage was T2bN0M0.

Results
The patient underwent radical prostatectomy, salvage radiotherapy + androgen deprivation therapy, abiraterone, enzalutamide, Radium-223, docetaxel + prednisone chemotherapy and mitoxantrone + prednisone chemotherapy, which included almost all of the current domestic treatment regimens. The patient lived for 57 months from the initiation of treatment.

Conclusions
For the patients with high-risk prostate cancer, especially for elderly patients , they should firstly be recommended the treatment of radical radiotherapy + 2-3 years of androgen deprivation therapy. For young patients, radical prostatectomy + extended pelvic lymph node dissection as part of multi-modal therapies is considered to be a positive choice. However, for the patients with risk factors or recurrence after radical prostatectomy, the postoperative radiotherapy should be performed in order to reduce biochemical recurrence and improve local control. Currently, the order of choice of abiraterone, enzalutamide or docetaxel + prednisone chemotherapy, is based on the patient's situation, past history of treatment, symptoms, side effects as well as other related clinical features.

Key words:
Prostatic neoplasms; Localized high-risk; Multi-modal therapy; Radiotherapy


The kinetics of magnesium corrosion in O/sub 2/, CO/sub 2/, and N/sub 2/ atmospheres at 520 to 580 deg C was investigated. It was established that magnesium oxidation in dry and moist O/sub 2/ led to the formation of a MgO film and obeyed the linear time law. Magnesium oxidation in CO/sub 2/ took place only when the surface was specially treated (except for a certain initial period), and it obeyed the parabolic law. Oxidation in moist CO/sub 2/ gave no reproducible results. Corrosion in dry N/sub 2/ led to the formation of a Mg/sub 2/N/sub 3/ film and obeyed the parabolic law, and in wet N/sub 2/, magnesium corrosion obeyed the linear law. The maximum magnesium corrosion rate was observed in CO/ sub 2/, the minimum rate was observed in N/sub 2/. The presence of water vapor in CO/sub 2/ increased the oxidation rate markedly; in the case of oxidation in N/ sub 2/ or O/sub 2/, the presence of H/sub 2/O vapors speeded the reaction. The corrosion rate obeyed the Arrhenius temperature relationship. The energies of activation of magnesium oxidation (cal/ mole) are 47,920in dry O/sub 2/, 41,130 in wet O/sub 2/; 39,780 in dry N/sub 2/, 36,090more » in wet N/sub 2/; and 37,150 in dry CO/sub 2/.« less