A prospective study was conducted on 27 cases of infiltrating duct carcinoma of breast diagnosed by fine‐needle aspirate cytology (FNAC), subjected to mastectomy following the FNA diagnosis. Cytological grading, Bcl‐2 score, and quantification of apoptotic cell count were done on FNA material. Next, the carcinomas were graded on the corresponding histopathological sections. The overall concordance between cytological and histological gradings was 77.7%, with maximum concordance in Grade I tumors and minimum in Grade II. The mean apoptotic rates were 0.59 ± 0.722, 2.11 ± 0.707, and 2.95 ± 0.854 in Grades I, II, and III, respectively. Similarly Bcl‐2 scores were 1.36 ± 0.82, 0.22 ± 0.13, and 0.14 ± 0.116, in Grades I, II, and III lesions, respectively. When the cytological grade was correlated with histological grade alone, and subsequently along with Bcl‐2 scores and apoptotic rates, there was a significant improvement from 0.662–0.713 (P value, 0.001). Diagn. Cytopathol. 2002;26:356–359. © 2002 Wiley‐Liss, Inc.


The usage of air conditioning system to create a thermally comfortable environment in tropical countries is often a must, not necessarily luxurious any longer. However, the extreme usage of the system will lead towards higher consumption of energy and higher cost. A promising energy efficient model developed based on the Predictive Mean Vote (PMV) is analyzed and evaluated here to distinguish its workability. This model only requires the user to enter their respective PMV value (from -1 to +1) and the respective parameters will be inserted into the air conditioning system, which is based on the standard thermal comfort ISO 7730. Analyses and evaluations were done based on the measurements from human subjects and their feelings towards the surroundings were recorded to see the performance of the model. From here, more than 91% of the subjects agree with the parameters used in defining their thermal comfort. This proves the workability of the model towards controlling the air conditioning system in creating a thermal comfort ambience at lower energy consumption, and further simulative investigations are appreciated before implementation.


In accordance with types of cross-border M&A, integration patterns can be classified as follows:"dot integration", "chainintegration", "unit integration". Based on the differences of integration patterns, integration performance measure function is constructed. The results show that integration performance depends on the ability of heterogeneity asset match and the ability of homogenization asset absorption. Keywords—M & A mode, integration pattern, integration performance 整合绩效的决定:基于跨国并购整合模式的研究


The production of quasi‐definitive data at Ebre observatory has enabled us to detect a new geomagnetic jerk in early 2014. This has been confirmed by analyzing data at several observatories in the European‐African and Western Pacific‐Australian sectors in the classical fashion of looking for the characteristic V shape of the geomagnetic secular variation trend. A global model produced with the latest available satellite and observatory data supports these findings, giving a global perspective on both the jerk and a related secular acceleration pulse at the core‐mantle boundary. We conclude that the jerk was most visible in the Atlantic and European sectors.


As innate immune effectors,antimicrobial peptides play crucial roles in the evolution of insect species.In this study,three different antimicrobial peptide genes,DefA,CecE and MorB3,were sequenced from both Bombyx mori and its wild relative,Bombyx mandarina.Polymorphism analyses,neutrality tests,coalescent simulation analyses and linkage disequilibrium analysis to the obtained nucleotide sequences indicated that the three genes were subject to different evolutionary patterns: DefA was a target gene of artificial selection during domestication,CecE was a neutral gene that had undergone domestication bottleneck effect,and the major driven force of MorB3 was genetic drift.Despite of these varied evolutionary patterns,the three genes had higher levels of linkage disequilibrium in domesticated silkworm than those in wild silkworm,indicating that domesticated silkworm had experienced a recent bottleneck effect,and decrease of population size had led to the reduction in gene recombinant rate.Our results provide important information for understanding the evolution and function of different antimicrobial peptides in domesticated silkworm.


The electroluminescent (EL) performances of a green iridium complex tris(2-(4-tolyl)phenylpyridine)iridium Ir(mppy)3 were significantly improved by employing another hole-type iridium complex as a sensitizer.


In this article, we study the Heinz inequalities for two positive operators. We refine the ordering relations among the Heinz means with different parameters and obtain some improvements of the Heinz operator inequalities.


New studies have shown the benefit of initiating a hypothermia protocol in the survivors of cardiac arrest. Although the data have shown an improved neurologic end point in patients initially in ventricular fibrillation or pulseless ventricular tachycardia, there is still debate about whether patients initially in other rhythms would benefit from hypothermia after return of spontaneous circulation. This is a report of a 17-year-old male found to be in asystole after sustaining a TASER injury, who was treated with a hypothermia protocol after return of spontaneous circulation and left the hospital with intact neurologic function. Excellence in resuscitation has always been a foundation of emergency medicine. This includes following standard Advanced Cardiac Life Support (ACLS) and Pediatric Advanced Life Support (PALS) algorithms for patients in ventricular fibrillation, pulseless ventricular tachycardia, pulseless electrical activity, and asystole [1]. Recent focus has also included what other therapy can be offered once a return of spontaneous circulation is obtained [2-5]. We present a case of a pediatric patient in asystole after sustaining a TASER (Madison, Wisconsin) injury who was resuscitated with a hypothermia protocol. A 17-year-old boy with bipolar disease and polysubstance abuse was at home with his mother. He became aggressive, and the police were called. When they arrived, he was still agitated and was subdued with a TASER. He was struck in the left side of his chest and fell to the ground without any other injury. Twenty minutes later, it was noticed that he was still on the ground, unconscious, and not moving. Emergency medical services was called. When they arrived, they found him to be in asystole. Cardiopulmonary resuscitation was begun including intubation. He received epinephrine, atropine, and was defibrillated when he went into ventricular fibrillation. In the emergency department, he was initially in ventricular fibrillation and received epinephrine, defibrillation, amiodarone, atropine, and sodium bicarbonate. After return of spontaneous circulation, ice packs were applied to his axilla and chest, and an Alsius cool line was inserted for implementation of a hypothermia protocol. 0735-6757/$ – see front matter © 2009 Elsevier Inc. All rights reserved. In the intensive care unit, he remained sedated with fentanyl and versed, and on a levophed drip. Monitors showed him to be in atrial fibrillation with intermittent runs of ventricular tachycardia. He was cooled to 33 degrees for 18 hours and paralyzed with cisatracurium. Initial laboratory results showed rhabdomyolysis, acute renal failure, shock liver, hypernatremia, hyperphosphatemia, and cardiac ischemia (troponin I peaked to 160 ng/mL). In the intensive care unit, he went into pulseless electrical activity (PEA) twice but was successfully resuscitated. He slowly improved, and on hospital day 4, he opened his eyes and responded to stimuli. He moved all his extremities by day 5, followed purposeful commands by day 11, and had a tracheostomy and feeding tube placed on day 12. He was weaned from the ventilator and transferred to an inpatient rehabilitation center on hospital day 21, at which time it was noted that he could walk and did not have any noticeable focal neurologic deficits. Hypothermia after cardiac arrest was first reported in the 1950s [5]. In the 1990s, hypothermia began to be studied again for post–cardiac arrest patients and has been evaluated in patients with severe stroke and other injuries [4]. Studies have shown the promise of hypothermia in patients initially in ventricular fibrillation or pulseless ventricular tachycardia [4,5]. A study by the Hypothermia After Cardiac Arrest Study Group found a risk ratio of 1.40 and a number needed to treat of 6 to prevent one unfavorable neurologic outcome (Pittsburgh cerebral performance category 3-5) in patients with ventricular fibrillation or a nonperfusing ventricular tachycardia [5]. Bernard et al [4] found 49% of patients enrolled in the hypothermia cohort vs 26% of patients in the normothermia group had a good neurologic outcome. This study only included patients initially in ventricular fibrillation. The data on patients initially in PEA or asystole have not been as promising. Studies, including only small numbers of patients, have shown little change in both mortality and neurologic function when a hypothermia protocol was used [3]. Patients in these studies had a mean age of 57 and age greater than 70 years, respectively [3]. Our patient was 17 years old, which may have contributed to his good outcome. PALS does not endorse induced hypothermia in these patients. This case also involves the use of a TASER. Although studies have been done, they normally involve the use of


RCRA — Resource Conservation & Recovery Act 23% TSCA — Toxic Substances Control Act 12% Shortly after the study received wide circulation, a whistleblower told the Federal Government, which had funded this particular research, that Liburdy had manipulated his data. The Office of Research Integrity, a bureau within the U.S. Department of Health and Human Services that monitors many federally funded research projects investigated. Further examination revealed that Liburdy had discarded data in preparing a graph for his publication which did not fall on the line purporting to support the hypothesis. In fact, further examination revealed that Liburdy had used only 7% of the data generated during his studies. As a result, Liburdy requested of the scientific journals that had published his work that three key Directors Corner


Aims: To explore the role of language in the representation of students' understanding of concepts in the oral as well as the written form through collaborative concept mapping (CCM). The study attempts to identify the nature of difficulties faced by students in the same. Method: A descriptive research design was used for the study. A school was selected purposely of which all the 28 students of a section of class IX were taken as the sample to represent their understanding of selected science concepts through collaborative concept mapping. Students formed 9 groups to draw the concept maps collaboratively. The whole process of CCM by each group was observed to identify the students' actual understanding of the science concepts. The concept maps made by each group were examined qualitatively to compare the representation of students' knowledge in the written form with their actual understanding. Findings: In the study language was found to play an important role in the concrete representation of knowledge in the form of a graphic organizer like a concept map also. Some concepts were identified in the study which were discussed among the group members but not included in the map due to their inability to select appropriate linking words. It was also found that technical terms and labels in science posed a challenge for students. But, in some cases CCmaps provided them a tool through which the correct comprehension of the concepts can be given a concrete form despite having the limited knowledge of language. Novelty: The study provides an insight into the application of CCM as an assessment technique by teachers to compare the students' cognitive structures and their overt representation on paper. It has also identified a specific form of concept map by which students can represent their understanding with the limited knowledge of language.
Keywords: Role of language; Collaborative Concept mapping; understanding of concepts; representation of knowledge; Science


In the field of electrochemical detection, ferrocene has a promising application prospect in view of its impact as a component of molecular receptors and sensing materials. In this review, we aim to describe the principle of ferrocene-based electrochemical detection and further discuss its design and performances. In particular, two forms of detection, molecular recognition and sensing systems, were specified. Ferrocene-based molecular receptors with all kinds of structures covering derivatives, polymers, and supramolecular receptors are presented. Benefits of their structures to the recognition behavior are compared and discussed. In electrochemical sensors, the ferrocene-containing component is used as a mediator or a label. The architectural design, enhancement effect of additives, and the structures of ferrocene-containing components in the corresponding sensors are discussed in this review. Among sensors with different structures, film-type, sandwich-type, and displacement-type sensors are the main a...


Benzanthrone dyes, a well known class of fluorescent compounds with emission in a wide spectral region, have found numerous applications in different areas as laser dyes, disperse dyes for textiles and polymers, daylight fluorescent pigments, fluorescent probes for biomedical technologies, etc. Our previous studies provided evidence for the applicability of benzanthrones to detecting beta-structured protein aggregates, amyloid fibrils, that are thought to be involved in the development of more than 40 human disorders.


Summary Natural killer (NK) cell activity is impaired in Chlamydia trachomatis‐infected patients. The mechanisms behind the altered NK functions are not clear, but data concerning NK and antibody‐dependent cellular cytotoxicity (ADCC) activity have been reported. To investigate whether this impairment is related to a defect at the target cell binding and/or the postbinding level, we evaluated highly purified NK cells obtained from 125 C. trachomatis‐infected patients and compared them with 101 normal controls for their ability to kill K‐562 and U‐937 cell lines using a 51Cr release assay; release tumour necrosis factor‐alpha (TNF‐α) and interferon‐gamma (IFN‐γ); and kill anti‐IgM preincubated P‐815 cell line (ADCC activity). We found a decrease in the lytic capability of NK cells from C. trachomatis‐infected patients against target cell lines; decreased ability to kill bound target cells; and low levels of released TNF‐α and INF‐γ after incubation with U‐937 cells. Taken together, these findings suggest that the impaired NK cell reaction during chlamydial infection is related to defects both at the target and postbinding levels. However, the precise mechanisms remain to be determined. The inability to restore normal NK activity after long‐term culture in the presence of high levels of recombinant IL‐2 support the hypothesis of an anergic process during chlamydial infection.


Multiple sclerosis (MS) is an autoimmune disease mediated by myelin autoantigen-specific T cells. Experimental autoimmune encephalomyelitis (EAE) induced by immunization of mice with a myelin oligodendrocyte glycoprotein (MOG) peptide emulsified in killed Mycobacterium tuberculosis-containing complete Freund's adjuvant (CFA-EAE) is frequently used as a model of MS. Mycobacterium bovis BCG, a vaccine strain with various biological response modifier activity, has been reported to ameliorate clinical symptoms of the CFA-EAE although precise mechanism has not yet been documented. Since the CFA-EAE uses adjuvant with mycobacterial antigens, it is possible that mycobacterial antigen-specific T cells induced by CFA and those by therapeutic BCG inoculation recognize same antigens, and the cross-reactivity modulate the EAE. To exclude the influence of the cross-reactivity, we established a modified murine EAE model (CWS-EAE) which does not induce mycobacterial antigen-specific T cells. Inoculation of BCG 6 days after the CWS-EAE induction successfully ameliorated EAE symptoms, suggesting the therapeutic effects of BCG is independent of the mycobacterial antigen-specific T cells induced by CFA-EAE protocol. With the CWS-EAE model, we confirmed that induction of MOG-specific Th17 in the spleen and central nervous system (CNS) decreased with disappearance of demyelination lesions by the BCG inoculation. The amelioration of CNS pathology was not linked to changes in the number of macrophages, neutrophil and conventional dendritic cells (DC) but associated with decrease of plasmacytoid DC in CNS. The results suggest that BCG inoculation suppress both systemic and CNS Th17 response in the EAE mice and the mechanism may involve modulation of plasmacytoid DC.


To design a hands free replacement for standard crutches used by those
who are actively involved in sports whether professional athletes or normal
people and provides an answer to the mobility problems of some people with
temporary disabilities or injuries face in the problems of a lower leg injury.
Designing an innovative hands-free walking aided tool is a product to fulfill
customer needs especially for those who are temporary impairment (injury)
people for rehabilitation process or move in their daily activities better. This
research will focus on designing an innovative hands-free walking aid in for
problems and pain points, better support, material and functionality that
creates more comforts and a more easy motion of operation. There are
several aspects which will be considered on this project such as high
strength, ergonomics and the feasibility of users weight load restricted to
thigh to secure where the main point of the lock supports attaches to the
users is. Material used on this project consists of lightweight material such
as hollow aluminum steel tube in order to support certain weight capacity and
built with specific height in order to meet the ergonomic aspect to produce
comfortable and friendly product. This wearable product also built with
specific adjustable height and different size in order to meet the ergonomic
requirement. Furthermore, the size as well as the height of this crutch can be
adjusted. Hence, different people can use it easily. The piece can be
disbanded and stored when it is not in use. Further work need to be done on
this design includes checking for manufacturability of all the parts.


Miniature slow light Surface Nanoscale Axial Photonics (SNAP) devices are reviewed. The fabrication precision of these devices is two orders of magnitude higher and the transmission losses are two orders of magnitude smaller than for any of the previously reported technologies for fabrication of miniature photonic circuits. In the first part of the report, a SNAP bottle resonator with a few nm high radius variation is demonstrated as the record small, slow light, and low loss 2.6 ns dispersionless delay line of 100 ps pulses. Next, a record small SNAP bottle resonator exhibiting the 20 ns/nm dispersion compensation of 100 ps pulses is demonstrated. In the second part of the report, the prospects of the SNAP technology in applications to telecommunications, optical signal processing, quantum computing, and microfluidics are discussed.


Simple Summary In animals, especially in fish, dermal neoplasms are a common finding. A distinction between peripheral nerve sheath tumors (PNSTs) and other spindle cell tumors (SCTs) is not always possible when relying exclusively on routine cytological and histopathological findings. The current study aims to determine a minimal subset of stains required to correctly identify PNSTs in goldfish and describes, in detail, six dermal nodules that resemble atypical neurofibroma in humans. Interestingly, muscular and fibroblastic tumors were excluded using Azan trichrome staining, while Alcian blue and Gomori's reticulin stains revealed the presence of intratumoral areas of mucins and basement membrane fragments, respectively. In addition, PAS and PAS with diastase pretreatment confirmed the latter finding and revealed intra- and extracellular glycogen granules. Immunohistochemistry displayed reactivity for S100 protein, CNPase, and phosphorylated and non-phosphorylated neurofilament-positive axons. Altogether, these findings suggested that Azan trichrome staining, Gomori's reticulin staining, and immunohistochemistry for S100 protein and CNPase represent a useful set of stains to identify and characterize PNSTs in goldfish. Abstract Skin spindle cell tumors (SSTs) frequently occur in fishes, with peripheral nerve sheath tumors (PNSTs) being the most commonly reported neoplasms in goldfish. However, distinguishing PNSTs from other SCTs is not always possible when relying exclusively on routine cytological and histopathological findings. Therefore, the aim of this study is to characterize six skin nodules, resembling atypical neurofibromas in humans, found in six cohabiting goldfish (Carassius auratus), and to determine a minimal subset of special stains required to correctly identify PNSTs in this species. Routine cytology and histopathology were indicative of an SCT with nuclear atypia in all cases, with randomly distributed areas of hypercellularity and loss of neurofibroma architecture. Muscular and fibroblastic tumors were excluded using Azan trichrome staining. Alcian blue and Gomori's reticulin stains revealed the presence of intratumoral areas of glycosaminoglycans or mucins and basement membrane fragments, respectively. PAS and PAS–diastase stains confirmed the latter finding and revealed intra- and extracellular glycogen granules. Immunohistochemistry displayed multifocal, randomly distributed aggregates of neoplastic cells positive for S100 protein and CNPase, intermingled with phosphorylated and non-phosphorylated neurofilament-positive axons. Collectively, these findings are consistent with a PNST resembling atypical neurofibroma in humans, an entity not previously reported in goldfish, and suggest that Azan trichrome staining, reticulin staining, and immunohistochemistry for S100 protein and CNPase represent a useful set of special stains to identify and characterize PNSTs in this species.


There is strong evidence, much of it provided in the 25-year update17, to explain why the cnbss is indeed an outlier among randomized trials in failing to demonstrate a mortality reduction associated with an invitation to mammography screening. Although Narod's loyalty to his mentor is commendable, I believe that if he were to study this evidence carefully, he would understand why the cnbss results should not be used to influence screening policy. To the extent that his article and the articles by Baum13 and Foulkes14 in the same issue of Current Oncology use the cnbss results as the foundation of their arguments discounting the value of mammography screening, while ignoring the large body of evidence supporting the benefits of mammography, they do an injustice to women for whom such programs represent one of the few proven interventions that can reduce their risks of death from breast cancer and of the morbidity associated with treatment of advanced disease.


A CO2 laser (∼0.5 kJ energy, 50–80 ns pulse width) was focused onto the end of an axially oriented, thick (35–350 μ) carbon fiber with or without a magnetic field present along the laser‐fiber axis. We present evidence for axial‐to‐transverse enhancement of the C VI 182 A (n=3–2) transition, which is correlated with the appearance of a population inversion between levels n=3 and 2. For the B=0 kG, zero field case, the maximum gain length product of kl≊3 (k≊6 cm−1) was measured for a carbon fiber coated with a thin layer of aluminum (for additional radiation cooling). The results are interpreted in terms of fast recombination due mostly to thermal conduction from the plasma to the cold fiber core.


Normal-pressure hydrocephalus (NPH) has rarely been reported to be associated with trigeminal neuralgia (TN). We report a case of NPH with trigeminal neuralgia, whose symptoms completely resolved after endoscopic third ventriculostomy. We will notify another surgical management of trigeminal neuralgia, considering the different pathophysiology of TN and a brief review of the literature. © 2019 Tehran University of Medical Sciences. All rights reserved. Acta Med Iran 2019;57(12):731-732.


The provision of public goods and the amelioration of market failure are the classical justifications for government intervention in the economy. In reality, (1) governments intervene in markets that are not affected by failure, and (2) a large share of the government resources is spent in private goods, not in public goods. In contrast to issue 1, issue 2 has received little attention in the literature, in spite of the potentially large efficiency and equity losses arising from misguided allocations of public expenditures. Lopez empirically documents the size of (2) in the rural sector and investigates its consequences for rural development for 10 Latin American countries over the 1985-2000 period. The econometric evidence suggests that the structure of public expenditures is an important factor of economic development in the rural sector, much greater than that of the level of public expenditures and of other factors on which the development literature has traditionally focused. Expanding total public expenditure in rural areas while maintaining the existing public expenditure composition prevailing in certain countries does little to promote agricultural income and reduce rural poverty. Spending a significant share of government resources in (non-social) subsidies causes less agriculture income, induces an excessive reliance of agriculture on land expansion, and reduces the income of the rural poor.


A case of opsoclonus and palatal myoclonus following blunt head injury is described. The syndrome appeared 1 month after the injury and lasted unchanged until death. Postmortem examination showed the presence of widespread lesions of the brain stem affecting the dentato-rubro-olivary system. The main clinical features of the syndrome and their anatomical correlates are discussed.


The long-time evolution of a flow structure subject to background rotation and a coaxial uniform magnetic field is investigated in this paper. The conditions of magnetic Reynolds number $Rm\ll 1$ and Rossby number $Ro\ll 1$ apply, while the condition of magnetic interaction parameter $N\gg 1$ ensures that nonlinear inertial forces are small in the system. Cylindrical polar coordinates $(s,\unicode[STIX]{x1D719},z)$ are used, where the velocity and the induced magnetic field are axisymmetric. Two regimes are analysed in the inviscid limit, that of strong rotation, where the inertial wave frequency is much higher than the Alfvén wave frequency, and that of weak rotation, where the Alfvén wave frequency is dominant. In either regime, the evolution consists of a damped wave-dominated phase followed by a diffusion-dominated phase. For strong rotation, the laws of energy decay in the damped wave phase are obtained by considering the decay of the fast and slow magneto-Coriolis (MC) waves individually. The diffusion-dominated phase obeys the decay laws in the well-known quasistatic approximation. The wave–diffusion transition time scale indicates that the wave phase of decay is very long, so that small-scale turbulence is characterized by damped wave motions. The ratio of kinetic to magnetic energies of the slow MC wave in the early stages of evolution is $O(Le^{2})$ , where $Le$ is the initial ratio of the inertial wave to Alfvén wave time scales. The induced magnetic field is hence far more efficient than the velocity in supporting slow MC waves for $Le\ll 1$ . In the regime of weak rotation, the fast and slow MC wave solutions merge and tend to the classical damped Alfvén wave solution. Here, the decay laws in non-rotating magnetohydrodynamic turbulence (Moffatt, J. Fluid Mech., vol. 28, 1967, pp. 571–592) are recovered. Computations of the general solution for the long-time decay of an isolated vortex confirm the theoretical energy scalings as well as the wave–diffusion transition time scale of the kinetic energy. It is shown that a magnetically damped system that initially generates Alfvén waves because of relatively weak rotation can subsequently give rise to MC waves. Small-scale motions of $Rm\sim 1$ in the Earth's core probably generate slow magnetostrophic waves only for $Le>0.1$ , which suggests that a mean intensity of ${\sim}10~\text{mT}$ or higher is plausible for the toroidal magnetic field within the core.


Consider a graph $G$ and a real-valued function $f$ defined on the degree set of $G$. The sum of the outputs $f(d_v)$ over all vertices $v\in V(G)$ of $G$ is usually known as the vertex-degree-function indices and is denoted by $H_f(G)$, where $d_v$ represents the degree of a vertex $v$ of $G$. This paper gives sharp bounds on the index $H_f(G)$ in terms of order and size of $G$ when $G$ is connected and has the maximum degree at most $4$. All the graphs achieving the derived bounds are also determined. Bounds involving several existing indices - including the general zeroth-order Randi\'c index and coindex, the general multiplicative first/second Zagreb index, the variable sum lodeg index, and the variable sum exdeg index - are deduced as the special cases of the obtained ones.


72 ABSTRACT The use of the immediate load in maxilo-mandibular rehabilitation accelerate the restoration of the function mastigatory of the patient. The zigomatic implant developed by Brånemark in the decade of 1990 brought a new perspective to the patients with severe jaw atrophy . In an effort to promote a free proceeding of grafts, to offer a solution that allows the immediate load and simplifi cation of the original protocol, several authors investigated new techniques for it installation and alterations in the design to perfect the aesthetic and functional results. The present report of clinical case demonstrates the removal of clinically unstable dental implants and the realization of a total rehabilitation with zigomatic implants associate to dental implants subjected to the functional immediate load.


ERp57 is a kind of disulfide isomerase with multiple biological functions. When compare with normal silk worm egg total proteins, a kink of parthenogenesis related protein, calcium-binding protein-ERp57, is obtained from parthenogenetic silkworm egg total proteins by two-dimensional gel electrophoresis (2DE) technology. According to the cDNA library, we clone the ERp57 full length cDNA from silkworm pupae. Furthermore, using bioinformatics methods and tools, we analyze this gene both in DNA and protein level. It will provide favorable reference for further studies in its structure and functions.


Let $E$ be a semistable elliptic curve over $\mathbb{Q}$. We prove weak forms of Kato's $K_1$-congruences for the special values $ L\bigl (1, E/\mathbb{Q}( \mu _{p^n},\@root p^n \of {\Delta } )\bigr ) . $ More precisely, we show that they are true modulo $p^{n+1}$, rather than modulo $p^{2n}$. Whilst not quite enough to establish that there is a non-abelian $L$-function living in $K_1\bigl ( \mathbb{Z}_p[[ \rm {Gal} ( \mathbb{Q}( \mu _{p^\infty },\!\!\@root p^\infty \of {\Delta } )/\mathbb{Q}) ]] \bigr )$, they do provide strong evidence towards the existence of such an analytic object. For example, if $n=1$ these verify the numerical congruences found by Tim and Vladimir Dokchitser.


Implementing an Australian National Curriculum will require targeting both teachers and preservice teachers. Classroom teachers in their roles as mentors are well situated for developing preservice teachers. This mixed-method study presents mentors' reports on their mentoring of primary preservice teachers (mentees) in mathematics (n=43) and science (n=29). Mentors claimed they mentored the teaching of mathematics more than the teaching of science; 20% or more indicated they did not provide mentoring practices for 25 out of 34 survey items in the science and 9 out of 34 items in the mathematics. Mentors also claimed that professional development on effective mentoring can enhance their skills. Implementing an Australian National Curriculum necessitates professional development for mentors on effective mentoring practices in order to increase the quality and quantity of mentoring for enhancing preservice teachers' practices. The last attempt at implementing a national curriculum failed in the 1990s largely because it was not followed through with the enactors of reform (Collins, 1994; Ellerton & Clements, 1994). From personal experience as a principal of a NSW school at the time, the national curriculum documents arrived in schools and were left on shelves. There was no professional development provided. In the current era, teachers and preservice teachers require development to ensure the Australian National Curriculum is implemented according to its documentation. Importantly, where teachers and preservice teachers meet becomes a rich environment for pedagogical discussions about new developments that can further advance the implementation of national agendas. Supporting the need for an "Education Revolution", as part of the $42 billion stimulus package (Department of Education, Employment and Workplace Relations, 2010), is the list of critical reviews into Australian education over the last decade or more (see Nelson, 2002; Ramsey, 2000). Most reviews highlight the necessity to improve Australia's education system (e.g., Bradley, Noonan, Nugent, & Scales, 2008; Masters, 2009). Many reviews focus specifically on teacher education within school settings and tertiary education for those about to enter the profession (e.g., Bradley et al., 2008; House of Representatives Standing Committee on Educational and Vocational Training [HRSCEVT], 2007). Indeed, the latest results from NAPLAN (2009) and the Queensland Premier's Green Paper (Department of Education and Training, 2010) further emphasise the need for educational reform. The Green Paper highlights the need to improve the quality of teaching, as the "quality of this training and support can impact on student learning. Bad experiences can mean that potentially talented teachers leave early in their careers" (p. 19). Surprisingly, this paper does not mention mentoring as a way to facilitate the development of preservice teachers. There are only two ways to reform an education system, namely through inservice education of existing teachers and preservice teacher education. An education revolution will need to be enacted by teachers and preservice teachers if change is to filter throughout a Australian Journal of Teacher Education Vol 35, 7, November 2010 31 system. In addition, the Australian National Curriculum is intended as part of the education revolution fabric to connect Australian states and territories more cohesively (Australian Government, 2008). This uniformity is also intended as a way for education to be more accountable across states and territories, where students who graduate in one location can be measured at the same educational standards as any other student in Australia. The National Curriculum Board has provided many documents in a consultative manner towards developing an Australian Curriculum across the range of subject areas (e.g., English, mathematics, science, and history). It also advises that there will be "sufficient flexibility and support so that educators can adapt its contents and processes according to their students' needs" (National Curriculum Board, 2008, p. 5). However, to implement the Australian Curriculum will require targeting the key enactors of such reforms, viz: teachers and preservice teachers. Most importantly will be the dialogue that occurs between these two parties to gather cohesiveness. Consequently, mentoring is where these two enacting parties (preservice teachers and teachers) meet within school settings. Indeed, classroom teachers in their roles as mentors have a significant role to play for developing preservice teachers, where approximately one sixth of the time allocated in a 32-unit degree is held within the school setting. Preservice Inservice Figure 1. Enactors of educational reform It appeared that the enactors of reform were not supported sufficiently with professional development in the 1990s attempt at a national curriculum (Marsh, 1994). Furthermore, mentormentee interactions were not considered in this reformation. Teachers would need to develop their practices in line with current documents in order to dialogue with mentees. Hence, a learning community could come together through purposeful discussions around new innovations such as the Australian Curriculum. Teaching is an interpersonal, emotional and social profession. Similarly, mentoring requires "real-time" interactions, and although 21 Century technologies may be used to support mentoring (e.g., Maxwell, Harrington, & Smith, 2010), the personal relationship between the mentor and mentee and timely interventions are pivotal to the mentoring process (e.g., Ganser, 1996). To have an understanding of how mentors would operate in this new endeavour requires investigation of how they have worked with preservice teachers (mentees) in the past. Recognising mentoring patterns, gaps, and affirmative actions can assist to plan more effectively for mentors' involvement in curriculum reform. The literature has grown significantly in the area of mentoring with journals dedicated to such works (e.g., Mentoring & Tutoring: Partnership in Learning; International Journal of Mentoring & Coaching), and empirical evidence has been gathered to present effective mentoring practices for guiding a preservice teacher's development. There is value in mentoring about school culture and infrastructure, which includes knowledge about the school, staff, wider M E N T O R I N G Australian Journal of Teacher Education Vol 35, 7, November 2010 32 community, codes of conduct, emergency operations, and information about school traditions and procedures; however this study focuses on classroom practices and mentoring for effective teaching. A five-factor model of mentoring for effective teaching has previously been identified, namely, Personal Attributes, System Requirements, Pedagogical Knowledge, Modelling, and Feedback (Hudson, 2007, Figure 2). There are mentoring attributes and practices associated with each factor, which have been justified statistically with empirical evidence in previous works (e.g., see Hudson, 2007, Hudson, Skamp, & Brooks, 2005); these attributes and practices are summarised as follows. Figure 2. Mentoring Model Personal Attributes: This includes being supportive of the mentee, comfortable in talking about teaching practices and attentive listening to the mentee. The mentor's personal attributes are used to encourage the mentee's reflection on practices, and instil confidence and positive attitudes in the mentee. System Requirements: In its simplest form, the mentor needs to articulate the aims, policies, and curricula required by an education system. However, the complexities for implementing system requirements may be noted in the pedagogical knowledge mentors need to articulate for effective teaching. Pedagogical Knowledge: Effective mentors articulate how to plan for teaching; they timetable or schedule lessons for the mentee. Preparation for teaching needs to be discussed, particularly with the location and use of resources. Teaching strategies are key to effective lesson delivery for which an effective mentor can provide experienced perspectives. A mentor needs to check on the mentee's content knowledge to ensure it is in keeping with the system requirements and appropriate to the grade level. There are incidental problems that arise during lessons for which the mentor can assist in explaining how to problem solve. Classroom management strategies, including managing student behaviour must be discussed with the mentee, especially as the mentor has insight into the various student personalities and behavioural traits. Effective teaching requires astute questioning skills for which a mentor can discuss higher and lower-order questions along with distributing the questions in equitable ways. Lessons have a structure and so an effective mentor can discuss the implementation processes (e.g., ensuring key learnings or concepts are apparent in the introduction, body, conclusion of a lesson). Mentors can provide pedagogical knowledge about assessment and also viewpoints about effective teaching practices that link curriculum, pedagogy, and assessment. Modelling: The mentor's enthusiasm as a teacher can present desirable teaching traits. Importantly, the teacher-student relationship is central to teaching and demonstrating a positive rapport with students can show the mentee how these behaviours can facilitate learning. The mentor also needs to model appropriate classroom language suitable for student Australian Journal of Teacher Education Vol 35, 7, November 2010 33 learning, teaching (if not what to do what not to do), effective teaching, classroom management, hands-on lessons, and well-designed lessons. Feedback: Effective mentors articulate expectations and provide advice to the mentee, they review lesson plans, observe the mentee teach, provide oral and written feedback, and further feedback on the mentee's evaluation of their teaching and the le


Background: Recent evidence suggests that both neutrophilic and eosinophilic inflammation persist in the airways of patients with severe asthma. Neutrophils can secrete a variety of mediators which may augment the migration of eosinophils. We have reported that activated neutrophils augment the trans-basement membrane migration (TBM) of eosinophils in vitro. Theophylline has been shown to modulate some functions of both neutrophils and eosinophils. The objective of this study was to evaluate whether theophylline modulates the neutrophil-dependent augmentation of eosinophil TBM. Methods: Eosinophils and neutrophils were isolated from peripheral blood collected from healthy donors and were then preincubated with either 0.1 mM theophylline or the medium control. The TBM of eosinophils in response to IL-8 was evaluated in the presence or absence of neutrophils by using the chambers with a Matrigel®-coated Transwell® insert. The generation of O2– was evaluated by the cytochrome c reduction assay. Results: As previously reported, IL-8-stimulated neutrophils significantly augmented the TBM of eosinophils. Theophylline significantly attenuated the neutrophil-dependent augmentation of eosinophil TBM (p < 0.001) and did not directly modify the TBM of neutrophils in response to IL-8 or LTB4. Similarly, the LTB4-induced TBM of eosinophils was not modified by theophylline. Finally, theophylline attenuated the superoxide anion generation from IL-8-stimulated neutrophils on the Matrigel-coated plates. Conclusions: Our results show that theophylline can attenuate the neutrophil-dependent augmentation of eosinophil TBM. This effect is possibly attributable to the suppression of neutrophil activation provoked by the combination of basement membrane and IL-8.


Legal faith is significant for setting-up "running the country according to law",however the condition of our country's legal faith is troubling. It needs the joint efforts to train the legal faith of the social subject and to set up the socialist country governed by law by the government and the people.


This paper firstly tests three hypotheses regarding the effect of foreign investment inflow,namely, capital investment effect,market competition effect and technology spillover effect.The study finds that:(1) the capital investment effect has significantly positive impact on the efficiency of insurance operation,but has no influence on the efficiency of investment operation.(2) The market competition effect has significantly positive impact on the efficiency of insurance industry.Compared with the increasing assets and market share of foreign insurers,the increasing number of foreign insurers has more significant effect on the efficiency improvement; (3) The insurance companies' efficiency and foreign investors' holding ratio shows a U-shaped relationship, which indicates that the technical spillover effect will have positive impact on the efficiency of China's insurance industry when the ratio of foreign shareholders reaches a certain level.


A previous report demonstrated the therapeutic efficacy of a rabbit ovarian anti‐tumor serum (R.O.A.T.S.) in the serologic treatment of an experimental murine ovarian carcinoma. Purification of the tumor antigen led to production of a more purified tumor antiserum (SG200) which allows a multiple dose regimen without mortality. Cytotoxic testing of spleen and tumor cells with R.O.A.T.S., N.R.S., (normal rabbit serum), and SG200 antiserum reveal marked tumor cytotoxicity with R.O.A.T.S. and SG200 but not with N.R.S. When 106 tumor cells are inoculated and treatment is given on day one; days one and two; or days one, two, and three, control animals have 0% survival and treated animals 0%, 20%, and 20% survival for over 120 days. In a study with 104 tumor cells (to observe differences in multiple dose treatment) 10% survival is noted in untreated tumor controls and 60% survival in the group treated on days one and two; and 90% survival on days one, two, six, and seven. Purified tumor antiserum allows for treatment without mortality, successful multiple dose therapy, and a high degree of selective tumor specificity, thus approaching the specific targeting required. This is a model system which may find application in clinical practice.


Globalisation (in the sense of increased international trade) is usually associated with gains from trade but also distributional effects where e.g. capital owners gain and workers lose, both in real terms. In recent years, globalisation seems to be synonymous to international mergers of firms. This paper shows in a model with Cournot competition that international mergers due to globalisation also imply gains from trade. Under plausible assumptions for capital intensities and in contrast to the usual results, however, both capital owners and workers gain in real terms. This effect is due to the reduction in the consumption good price caused by an increase in competition.


Introduction The socioeconomic impact of aging population can be reduced if majority of people achieve successful aging. This study aimed to determine the prevalence of researcher's defined successful aging (RDSA) and self-rated successful aging (SRSA) among pre-retirement public servants and their predictors. Methodology The sample included 1,064 pre-retirement public servants (50 to 60 years old) from nine government agencies. Data was analyzed using Multiple Logistic Regression to test for the association between the studied factors and SA. Results The prevalence of RDSA and SRSA was 37.5% and 98.7%, respectively. Results showed four (4) significant factors with higher odds of having RDSA were not obese, good social support, being physically active and younger age. Meanwhile, five (5) factors highly selected by respondents as predictors for SRSA were having good spiritual or religious practice, happy family, good psycho cognitive function, social support and good physical function. Conclusion The prevalence of SRSA was higher despite the presence of self-reported chronic diseases and physical limitation identified among respondents. The discrepancy in both prevalence of SA reflects the differences that exist between the criteria for SA perceived by respondents and researchers. Misperception among respondents of their aging process as 'successful' despite having diseases or disability may worsen their health status because they continue practicing unhealthy lifestyles without action to improve it. Promotional activities on SA, regular health screening since young and healthy working environment should be implemented by various agencies. Keywords Successful aging - pre-retirement - public servants - predictors


The Dashigou deposit is one of the four main ore bodies of the Huanglongpu Mo-REE deposit cluster within the Qinling Mountains in Central China.The contribution was focused on geological and chemical study of molyblenite.


A First Course in Latin is an introductory Latin course in two highly-illustrated, large-format books, complete with a detailed teacher's guide. It will provide pupils with enough Latin to enable them to take up the Cambridge Latin Course with ease. To this end, the vocabulary and grammar are being tailored to match Unit 1 of the Cambridge Latin Course. It will also provide detailed information and project work on the Roman World, which will be of interest to all learners, regardless of whether they will continue with Latin. The storyline in the course is therefore mainly carried in the English background text and not in the Latin. The content and structure of the course provide inexperienced teachers, most of whom will not be Classics graduates, with a guided programme of basic work in the language and culture of the Roman Empire in the first century A.D.


At the time of Byeongja Holan, Qing TaeJong got submission from Injo who was the king of Chosun and the peace treaty include the clause "Whenever Qing attacks Ming, Chosun should support Qing with backup army". Based on this promise, RiwRim suppress Ming"s Army at Gado located to the CheolSan in Pyoungan province as commander in chief of Chosun with DaRaMuYeongGunWang AJeGyeok who is commander in chief of Qing and the fourth younger brother of Qing TaeJong in 1637. However Qing TaeJong requested to the king of Chosun that dispatch backup army with RiwRim as a head to join a close Jinzhou battle near to SanHaeGwan in 1638. RiwRim crossed ApRok river with 5000 soldiers, but he returned to Chosun due to broken court day by Qing TaeJong, then he lost his original position, PyungAnByungSa, according to military discipline, then he move to SamDoSuGunTongJeSa the next year. However, Qing TaeJong requested InJo who is the king of Chosun that backup army with RiwRim as a head join Jinzhou battle again in November. 1640. InJo appointed RiwRim as the commander in chief to prepare the battle. RiwRim started the journey from Seoul on February 20th, 1641 with 1000 firelock soldier, 500 kitchen police, 1155 horses to YoDong on March 24th then arrived Jinzhou on March 26th, 1641. In Jinzhou, HwaSeokJeongChinWang JeIHapRang, who is cousin of TaeJong, and DaRaMuYeongGunWang AJeGyeok was confronting the Ming army. Chosun-Qing allied forces attacked Jinzhou castle on March 27th, then occupied the outer castle with 6000 captives. The allied forces enticed and chased the Ming army, finally killed 171, captured 4343 on April 2nd, 1641. The Ming"s repeated defeat bring GyeongRyak HongSeungJu with 130,000 soldiers to Jinzhou. To respond this Qing TaeJong bring his army to Jinzhou on August 19th. At that time Qing TaeJong brought hostage SoHyeonSeJa and the BongRimDaeGun(= HyoJong) from SimYangGwan. There were furious battles during 10 days after arrival of Qing TaeJong. At his battle almost all of soliders of OSamGye, WangBak, BaekHwangEun, MaGwa, LeeBoMyeong, DangTong, and JangYakGi were killed toll 53783. Qing TaeJong brought RiwRim to the headquarters and comforted him on August 26th. At the Afternoon he gave a party and SoHyeonSeJa, BongRimDaeGun, RiwRim"s five generals were also invited to the party. Horses, cows, sheeps were distributed to the soldiers as a reward. RiwRim left SimYang on September 9th and arrived Chosun on September 18th. Qing TaeJong send a letter to InJo that RiwRim should have a special rewards. RiwRim placed ChaHeonDaeBu and was appointed to ChongYungSa, but replaced after 2 months later, moved back to SamDoSuGunTongJeSa, then he passed away with 63 years old in 1643.


BACKGROUND
Malignant rhabdoid tumor of the kidney in children is considered a distinct entity. Malignant tumors with rhabdoid features in adults in extrarenal locations and in children over the age of 5 years are considered phenotypic variants.

CASE
In a case of recurrent transitional cell carcinoma with rhabdoid features of the kidney in an adult, confirmed immunohistochemically and ultrastructurally, fine needle aspiration cytology showed discohesive, large- to medium-sized polygonal cells with eccentric nuclei; prominent nucleoli; abundant, pink cytoplasm; and paranuclear, eosinophilic density, corresponding to cytoplasmic eosinophilic globules seen in the histologic sections and cytoplasmic filamentous inclusions seen ultrastructurally.

CONCLUSION
The cytologic features of malignant rhabdoid tumors are characteristic.


In the discussion of this issue to be dis- cussed is about determining how to manufacture from start tracking (navigation structure), making the track- ing map, create, design the interface, the formation of elements, merging elements, action script programming (ActionScript).


Research activities normally consist of numerous works such as paper composition, discussions and surveys of literature. It is important for smooth accomplishment of research to strategically accumulate the context information (i.e. processes of the work, methods and results) and to skillfully utilize them. However, it is difficult to accumulate relevant context information since most automatic methods target only the specific work and/or researchers tend to selectively use different applications suitable for each purpose. This research aims to develop methods of organizing context information across the different styles of information and applications. This paper outlines methods to strategically accumulate context information and to organize it. Moreover, it describes an experiment using test-case data and discusses the effectiveness of the methods in light of the results.


ABS>Research is being conducted at Brookhaven National Laboratory to develop a superconducting ac cable system leading to the construction of a 1/2 mile model cable of 200 MVA capacity at Brookhaven and a cable of larger (>2000 MVA) capacity for test at a utility testing site. It is a coaxial cable of flexible design using Nb/sub 3/Sn superconductor, and a tape wound dielectric, helium impregnated, of a material yet to be determined. The research development is reported on the dielectric materials, cryogenic enclosure, refrigeration, and superconducting materials. (MCW)


Penalty kick procedure is one of the most challenging tasks in the robotic soccer games. This study was aimed to solve the problem of penalty kick goalkeeping for RoboCup Small Size soccer robots. Two different approaches were presented and compared to each other. The first approach was a simple hard-coded algorithm and the second one was based on reinforcement learning. In reinforcement learning (RL) in addition to the common reward function, a novel rewarding function was applied based on epoch value. The results extracting from both simulation and real experiments showed that the RL approaches were more successful in solving the problem in comparison with the hard-coded algorithm. Moreover, in the RL approach, the epoch based reward function was more suitable compared to the common reward function to solve the problem. In conclusion, RL based approaches with the epoch based reward function can be a proper choice for the problem compare to the hard-coded methods.


These are brief comments describing the history, process and purpose leading to the publication of 'Qualitative Methods in Health Research: Opportunities and Considerations in Application and Review' (NIH Publication No. 02-!5046, December 2001). For more extensive information regarding qualitative research methods, other research questions, funding history, and general information regarding the US National Institutes of Health (NIH) and its components, the reader is advised to consult NIH's websites, literature, program staff and previously funded researchers.


In this paper, we show the existence result of the following fractional p-Laplacian system (−∆)spu = f(x,u) in Ω, u = 0 in Rn\Ω, for a given datum f. The existence of weak solutions is obtained by using the theory of Young measures.


Part I 1. The distribution of alcohol between benzene and
aqueous solutions of (1) sulfuric acid, (2) sodium sulfate,
and (3) mixtures of perchloric acid and sodium perchlorate
has been studied. 2. Apparent values of equilibrium constants for the
formation of oxonium salts in aqueous solutions have been
calculated. Part II 1. It has been established that oxygen exerts an
inhibiting effect in the formation of the complex compounds
of mercury which catalyze the hydration of acetylene. 2. The hydration of acetylene has been shown to
be of first order with respect to acetylene. 3. The conditions for the rapid determination of
acetylene in the presence of oxygen by the bromate-bromide
method have been determined.


Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy, Neurosurgical Unit, Careggi University Hospital, Florence, Italy, Department of Experimental and Clinical Medicine, Section of Anatomy, University of Florence, Florence, Italy, Neurosurgical Unit, Cardinale Panico Hospital, Lecce, Italy, Department of Clinical and Experimental Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy


The zero-knowledge status authentication is a fascinating question of contemporary password research,and the elliptic curve is the cipher system having higher security in comparison with others.An improvement method of the zero-knowledge status authentication agreement based on elliptic curve is proposed in this article,which decreases verification times resulting in faster authentication speed,lower system complication and power consumption,moreover,offers higher security.


By using B-spline curve and technique of automatic drawing,CAD for glass container and its blow mould is described in this paper.Parametric modeling of glass containers,designing and calculating of the blow mould,automatic dimensioning,creating automatic ploting file have been completed.Real three-dimension glass containers and their mould can be displayed.


The leader-following consensus problem of the general fractional-order linear multi-agent systems via event-triggered control is considered. An effective event-trigger controller is designed, and then the leader-following consensus problem of the controlled multi-agent systems is studied by using the Lyapunov theory of fractional-order systems and linear matrix inequality method. The consensus condition and the convergence rate of the system are obtained based on the Mittag–Leffler stability of fractional-order systems. Simulation indicates the effectiveness of the theoretical results.


The Bracco Italiano is one of the oldest breeds of Italian pointing dogs, used for hunting ever since Renaissance times. After the Second World War it was included among the breeds officially recorded by the ENCI (the Italian Cynological Club), and since 1970 more than 23,000 animals have been registered; there are currently approximately 750 births per year. In this paper, we present the breed characterization of the population at the molecular level using 21 STR markers from the panels recommended for the 2006, 2008 and 2010 ISAG canine comparison test. Number of alleles, allele frequencies, deviations from Hardy-Weinberg proportions, linkage disequilibrium among loci, genetic similarity, genetic distances and molecular co-ancestry-based parameters were calculated. The number of alleles ranged from 3 to 9 (mean 6.43) whereas the expected heterozygosity ranged from 0.44 to 0.81 (mean 0.64). There was a high genetic similarity within the whole population (0.455) showing the great homogeneity of the sampled animals, as confirmed also by the small kinship distance (0.336), by the high values of the self molecular coancestry (0.703) and of the inbreeding coefficient (0.406). These results suggest the need for a careful genetic management of the population in order to avoid the risk of an excessive increase in the inbreeding level which would result in significant inbreeding depression and in significant loss of genetic variation.


Purpose
The purpose of this study is to conduct a bibliometric analysis to discover the published information on the subject of "Library Automation Software."

Design/methodology/approach
This study is based on bibliometric research to analyze the growth of literature on the subject area "Library Automation Software." The data were retrieved from the leading database Web of Science to analyze the scholarly publications on the topic during 2001–2022. To analyze the bibliometric data on the subject, the VOSviewer, Biblioshiny and MS Excel software were used.

Findings
Results manifest that the topic of "Library Management Systems" has been greatly used by several authors as a title to publish their research work. The USA emerged as the most productive country. The most used keywords to retrieve literature on the topic were "Library Automation," "Library Management Systems," "KOHA," "Integrated Library Systems" and "Open Source Software."

Originality/value
To the best of the authors' knowledge, this is the first bibliometric study in Pakistan that has been conducted to measure the productivity of literature at the international level on library automation.


This paper expounded that, before the Jin Dynasty (265-420), the contents of Gui Cang (《》)had never come out; while, since the Jin Dynasty, all versions of Gui Cang in different dynasties originated from Yi Yao: Yinyang Gua  excavated at the place of Ji in 281. The paper emphatically studied the relationship of source and course between Kun Qian (《》) called by the state of Song of the Spring Period (770476 BC) and Gui Cang called in Rites of Zhou of the Warring States Period (476221 BC), and pointing out that divination books excavated at Wangjiatai comprise two different versions of extracts from Gui Cang with divination by hexagrams being their main body. Therefore, it is advisable to name them Gui Cang·Divination by the 64 Hexagrams. 


Rantau village is a village that is not yet food secure in the Bengkayang district. Corn is one of the main village products but still uses conventional cultivation methods and has not implemented farming management, so its utilisation is not optimal. The crop yields in the form of shelled corn are sold to Singkawang at a price of IDR 4000 per kg. Lack of knowledge and skills, including corn diversification technology, is the reason why this village is not yet developed. The impact is that the use of corn to increase household food consumption patterns has not been carried out. One of the partners of this service program is the dissemination of technology to the community, one of which is PKK. The purpose of this service is to increase the knowledge and skills of PKK members so that they are able to improve food consumption patterns and initiate new income for families. The solution is to transfer processed diversification technology that is applied to food products, namely healthy noodles from corn and vegetables. Implementation methods include socialisation, technology dissemination, evaluation and monitoring. The target of this service is for at least 50% of PKK members to increase their knowledge of healthy noodles, apply noodle menus for social events, at least 3 PKK members and application for family food security, and at least 1 PKK member initiates commercialisation around the village.


The study of heavy solar wind implanted ions in lunar samples provides information on the composition of the modern solar wind and its possible changes in the past. We used the ARL ion probe at the JSC to measure concentration depth profiles of artificially implanted ions in terrestrial minerals and of natural elements on the surface of a recently exposed lunar plagioclase crystal. Polished sections of terrestrial labradorite were implanted with C and Cr ions at solar wind energies and terrestrial ilmenite sections were implanted with Na and Si ions and the resulting concentration depth distributions of the implanted elements were measured. These studies on terrestrial analogs were performed to study the shape of depth profiles as a function of energy, the retention of the implanted species under simulated lunar conditions (solar wind erosion by H and He), and diffusion during annealing. An improved depth resolution in the ion probe could be obtained with an analyzing NO2 beam of 9 kV. Previously observed broadening of the depth profiles with an obeam of 15 kV is attributed to knock-on effects by the analyzing ions. Implanted C and Cr are still retained in feldspar after additional irradiation with 1018 ions/cm2 of H and He suggesting retention of solar wind implanted heavy ions in lunar surface crystals for periods of at least 10,000 yr. Diffusive losses of Cr implanted into feldspar occurs only after annealing at more than 700°C making thermal diffusion of heavy ions on the lunar surface very unlikely. The analysis of the lunar feldspar crystal 76215,77 with the ARL ion probe showed enhanced surface concentrations of the elements C, Mg, P, Ti, Cr, and Fe. Under the assumption that the observed enhancements were caused by pure isotopes and not molecular interferences we could directly measure the concentrations of C, Mg, Cr, and Fe by using artificially implanted marker ions. Analysis with a high mass resolution CAMECA ion microscope showed a multiple peak structure at several masses but the behavior of the various peaks with sputtering time, the separation of the peaks and the measured peak ratios add evidence that the surface enhancements are due to pure isotopes. The amounts of some of the elements (C, Fe, and P) are grossly consistent with the hypothesis of their solar wind origin and the measured solar flare track and microcrater densities. Ti and Cr, however, are overabundant and the abundances of all six measured elements fit neither the solar wind hypothesis nor the hypothesis that the surface concentrations are caused by vapor deposits produced by meteorite impacts.


The increasing importance of music as a therapeutic benefit in mental hospitals has prompted this study. Numerous unscientific reports and papers concerned with music therapy have been published; however, material based upon controlled experiments and results is available which has proven valuable in the study of this growing aid for mental patients. The reference material in the following chapters has been organized and limited to objective reports produced by those who have devoted their interest and time to the facts about the use of music as a therapeutic agent in mental hospitals.


This article examines the annual and seasonal (winter and summer) changes in the frequency of occurrence of the main types of synoptic processes in the Lower Volga region in two natural climatic periods of the state of the earth climatic system - the stabilization period and the second wave of global warming. The frequency of occurrence of some types of synoptic processes revealed both climatic and seasonal differences. In the second wave of global warming, in comparison with the stabilization period, the frequency of cyclone impact on the Lower Volga region developed on the Arctic front and the number of Arctic anticyclones increase, and the frequency of polar-front cyclones and cases of the impact of the western periphery of the winter Asian anticyclone decreases. Seasonal differences in the frequency of occurrence were revealed in the Arctic anticyclones. During the second wave of global warming, these anticyclones penetrate into the Lower Volga region in summer more often than in winter. It is concluded that the contribution of the transformation factor to the observed warming increases and the role of summer seasons in the observed climatic changes increases, which is not typical for processes in the earth climatic system. It is indicated that obtained result is of great climatological significance and will serve the further development of the physical theory of climate.


Fe‐P amorphous ribbons were prepared by melt quenching, and the concentration and temperature dependences of electrical resistivity, magnetoresistance, and forced magnetoresistivity have been investigated. The room temperature electrical resistivity monotonically increases with P content. The Debye temperature determined from the temperature dependence of electrical resistivity of Fe‐P amorphous alloys is lower than that of Fe‐B amorphous alloys. The concentration and temperature dependences of the anisotropic magnetoresistance are not associated with the magnetization or the linear magnetostriction at low P contents. The magnitude of the negative forced magnetoresistivity becomes larger with increasing P content and temperature.


The palaeoecology of a sequence of five closely spaced mammalian assemblages in the English Late Eocene Bembridge Limestone Formation is studied using cladistic, seriation and ecological diversity methods, after assessing the collecting and taphonomic biases. Analysis of this sequence is important as it is temporally close to the terminal Eocene global cooling event. It is concluded that the assemblages probably reflect quite closely the species composition of the original living communities and that they indicate habitats ranging from an open wooded environment to dense forest. The oldest assemblage (limestone facies) indicates open wooded habitat and contains earliest occurrences of certain taxa in the English Eocene; these represent northward dispersal from southwestern Europe in response to changing climate. The more forested habitats occur higher in the sequence and are characterised by 'Lazarus' taxa, suggesting reversion to earlier existing environments. Small scale changes appear to relate to loca...


The projective differential geometry of a configuration composed of three ruled surfaces whose generators are in correspondence in sets of three has been discussed in two recent papers by the author. t It is the purpose of the present paper to present briefly an analytic basis for the projective differential geometry of a configuration composed of four ruled surfaces whose generators correspond in sets of four, each set containing one line element from each surface. This correspondence is brought about by choice of a parameter common to all four surfaces. For defining system we choose a set of eight ordinary first-order linear and homogeneous differential equations in eight dependent variables, together with four linear and homogeneous equations of order zero:


In this paper, the innovative phase control active tuned mass damper (PC‐ATMD) is developed so that the PC‐ATMD can achieve a 90° phase lag of structure to induce maximum power flow. The equation of motion and proposed phase control algorithms are derived in detail. By utilizing the ATMD velocity relative to structure and different structural measurement feedback, two phase control algorithms are, thus, proposed individually. The PC‐ATMD, which uses structural displacement feedback, is denoted as the phase control displacement feedback active tuned mass damper (PCD‐ATMD), whereas the use of structural absolute acceleration feedback is the phase control acceleration feedback active tuned mass damper (PCA‐ATMD). The control of PC‐ATMD is smooth, proportional, and neither full‐state system measurement nor estimation required. This paper also describes the optimal control gains of the PCD‐ATMD or PCA‐ATMD which can be determined by direct output feedback optimization method. The shear building structures that apply PC‐ATMDs are subjected to earthquakes. The results indicate that, after applying the PCD‐ATMD or PCA‐ATMD, the peak displacement and absolute acceleration of the primary structure are both well suppressed. Moreover, the PCD‐ATMD has comparable effectiveness than the traditional linear quadratic designed ATMD which uses full‐state feedback, while the PCA‐ATMD is only slightly less performance than the PCD‐ATMD but more feasible for the application related to tall building structures. Finally, the stability of the proposed algorithms is also verified. It concludes that the PCD‐ATMD and PCA‐ATMD are both quite stable systems in a certain range of control gains.


This report discusses the Production Test 105-2-P (Supplement A) -- Activity of Pile Discharge Water. Previous studies of pile discharge water have shown that one of two processes is responsible for the large but variable amount of Mn{sup 56} activity present in the water. One process is the production of Mn{sup 56} by the reaction Mn{sup 55} on manganese impurity in the water. The amount of such impurity has been shown to be too small to produce the observed amount of Mn{sup 56} unless the mean irradiation time is increased by a large factor due to temporary sticking of manganese on the surfaces in the tubes. The other process is the production by the reaction Fe{sup 56} on iron in the film. The present production test was designed to determine which of these processes is responsible for the troublesome Mn{sup 56} activity and to what extent the activity is increased due to sticking of manganese or iron in the tubes. 4 figs.


Computer software products have become a world-wide commodity. Yet little thought is given to how products that are shipped internationally should be designed to maintain a high level of usability. This tutorial looks at how this issue should be addressed in the user interface through interaction design, visual design, and through an understanding of the world's cultural differences.


'Waiting for Godot' is a play about behaviour which is identifiably religious from a sociological point of view, although not explicitly so. Because it is a play, it is an icon of implicitness, as plays don't say what they mean in the form of explicit messages from the author to the audience, but communicate implicitly through fictitious events and personages. In this particular play, the main characters demonstrate by means of what they say and do, that, for them, life's meaning is associated with a longed-for consummation, a life- and purpose- -giving encounter, and that the action of waiting for this provides the focus for all their other actions and intentions, affecting the way they interpret whatever occurs in their world. They are committed to waiting for Godot to arrive; a state of mind encapsulated within the symbolic scenario which is the play. In other words, then, their behaviour chimes with the three defining characteristics of Implicit Religion: commitment, integrating focus, and extensive effects which proceed from an intensive concern, when these occur in circumstances which are not associated with explicit religion of any kind. The tramps themselves never mention God or religion, and the play's author is recorded as saying 'If I had meant God I would have said God'. Nevertheless the parabolic shape and the poetic language of the play produce an effect similar to that of religious ritual.


A new type of tachometer carbon brush wear detection technology is proposed based on data acquisition and signal processing technology, the key of which is that the tachometer carbon brush output information is acquired and processed, moreover, the real time conditions of the carbon brush wear are detected and analyzed based on the time domain Eigen value analysis method. During the data processing process, the results of the dimensional parameter processing method are compared with the results of the dimensionless parameter processing method at the same time. Then, we find that the detecting precision is greatly promoted and measurement probability is guaranteed by reasonable threshold selection. Experimental results indicate that the technology proposed here has high stability, high reliability, and high detecting probability, which has great practical value and deserves being extended widely.


BACKGROUND
The objective of the present work was to determine whether fluid intelligence scores and individual temperamental traits may be used to predict drivers' reaction times in movement anticipation tasks.

MATERIAL AND METHODS
The study encompassed 68 young female drivers (aged 20-26 years), who had received their driver's licenses at least 2 years prior. Anticipatory performance was evaluated using the Perception Anticipation Movement Test (PAMT) consisting of 3 sets of computer tasks differing in the speed of the moving objects. The level of fluid intelligence was determined using Raven's Standard Progressive Matrices, and the temperamental traits with the Pavlovian Temperament Survey.

RESULTS
Intelligence was found to be significantly correlated with reaction time only in the second PAMT task set, for which it was also a good predictor. Findings suggested that a higher level of fluid intelligence in young female drivers was associated with longer reaction times in the movement anticipation task with objects moving at the medium speed level. Temperamental traits did not correlate with reaction times in all movement anticipation tasks, and they did not explain the participants' performance in the PAMT task sets.

CONCLUSIONS
This study expands the current literature by assessing the relationship between fluid intelligence, temperamental traits and reaction times in movement anticipation tasks with objects moving at different speeds. The outcomes of this study are discussed together with those of previous research. Med Pr. 2020;71(4).

http://medpr.imp.lodz.pl/pdf-118631-53708?filename=The role of intelligence.pdf


Aim: Work disability is a frequent and serious outcome of rheumatoid arthritis (RA), accounting for the greatest indirect costs of this condition. A longitudinal, long-term prospective study was conducted on a large cohort of RA patients (pts) to investigate the rate/risk of work disability and the factors that may be considered concomitant with and therefore predictors of work disability, using a broad series of clinical, laboratory and self-reported measures in all pts and in a subgroup of early RA pts. Methods: RA pt data from 1974 were recorded in a database at the Wichita Arthritis Center in which demographic, clinical, and pt self-reported variables were registered at every pt visit. In 1994, 823 RA pts were examined and interviewed about their employment and work history. The pts were asked for occupation data the start and stop dates of each job, the specific job title, the reason for which the job was stopped; demographic variables (sex, age, ethnic origin, education level, number of children, smoking history, total income, and current marital status); and clinical data [tender joint count, grip strength, health assessment questionnaire (HAQ), pain on a visual analogic scale (VAS), VAS global severity, AIMS anxiety and depression, co-morbid conditions, body mass index (BMI), and rheumatoid factor (RF)]. Values used in the prediction of work disability were those detected at the first visit, 2-year average values, and average values over the length of the study. Average variables were considered as full predictors when work disability could not be considered to have caused the predictor value. The primary analyses were Kaplan-Meier survival statistics and Cox regression. Proportional hazard assumptions were verified. Results: 79 out of the 823 RA pts (9.6%) never worked for a salary. All the males and 87.3% of the females had been employed with a salary. 509 pts were employed at the time they had RA: the following statistical analyses were limited to these subjects. Work discontinuation was reported by 37.7%. The median survival time or time to work disability was 20.9 years, but the 25% survival time was 6.4 years. Out of 456 pts working at the first visit, 23% were work disabled in the first 5 years (8.6 in the first 2.5 years), 19.4% in the next 5 years and 57.6% beginning after 10 years of follow-up. The 25% survival time (time to work disability) was 10.05 years. Fewer years of formal education, a high BMI (showing a late e ffect on wo rk disab i l i t y ) , VAS pain score s , high HAQ scores, high RF and erythrocyte sedimentation rate (ESR) values, and high physical demands of the job were the covariates independently associated with work disability. Over the course of the illness, the work disabled patients had a 35% reduction in family income, and more abnormal scores for the joint count, grip strength, ESR, depression and anxiety. The results, except for BMI, were essentially similar in a subset of 156 pts in whom RA duration was less than one year. Conclusions: Work disability in RA pts was frequent and could be predicted by almost all of the demographic and clinical variables and by the physical characteristics of the work process present at the first visit. The best predicting factors were a persistent elevation of ESR, pain, and disability according to HAQ detected in longitudinal follow-up. Thus,the optimal management of RA pts may differ based on their clinical, demographic, and work variables. The physician should try to treat the clinical variables medically and to m o d u l ate the demographic and wo rk va ri ables by active interaction with the patient, calling in other specialists (e.g., psychiatrists or psychiatrics) where necessary.


Objective To study the relationship between duodenctasis and Treitz ligament after Billroth Ⅱ subtotal gastrectomy. Methods Drawing a lesson from one case of duodenectasis, the location,longitude, hypertrophy,tesion of Treitz ligament and its site at duodenojejunal flexure in 125 cases undergoing Billroth Ⅱ subtotal gastrectomy were observed. The anastomotic type was selected. Results No genesis obstruction of afferent loop,douoodenectasis and duodenal remains end fistula occurred. Conclusions Treitz ligament and duodenojejunal flexure had some anatomy implication in Billroth Ⅱsubtotal gastrectomy.


Hayes, "The Role of Reaction Products. In The Silver-Cata lyzed Oxidation of Ethylene", Can. J. Chem. 38,2256-2268 (1960). Flank et al., "The Geometric Factor in Ethylene Oxidation Orer Gold-Silver Alloy Catalysts", J. Catalysis, 8,316-325 (1967). Geenen et al., "A Study of the Vapor-Phase Epoxidation of Propylene and Ethylene on Silver and Silver-Gold Alloy Catalysts". J. Catalysis 77, 499–510 (1982).


To identify the preferences for sexual information resources of patients before and after definitive treatment for early‐stage prostate cancer with either radical prostatectomy (RP) or brachytherapy.


Carmelo Mesa-Lago and Jorge Perez-Lopez. Cuba under Raul Castro: Assessing the Reforms. Boulder, CO: Lynne Rienner Publishers, 2013. xv + 293 pp.Distinguished economists and pioneering scholars Carmelo Mesa-Lago and Jorge Perez-Lopez have written the most wide-ranging, provocative, and deeply researched discussion available of the nature, political underpinnings, and impact of Raul Castro's unprecedented economic reforms. Eminently accessible to a broad, interdisciplinary audience, Cuba under Raul Castro: Assessing the Reforms relies on a historically informed approach that elucidates how recent policies form part of a larger pattern of policy making that has been in place since Cuba's turn toward Communist Party-planned development in 1961. Like these authors' previous works, especially the contributions of Mesa-Lago in the 1970s and 1980s, this book exposes much of Cuba's day-to-day realities by excavating statistical data that is extremely difficult to obtain in a country with long traditions of treating economic indicators and observably negative policy outcomes not as issues for scholarly or open debate but as matters of national security.By their own admission, Mesa-Lago and Perez-Lopez affect a refreshingly light interpretive touch in tone and style, seeking to provide a "balanced and objective" analysis, free of the usual political agendas that so marked evaluative studies throughout the revolution (xv). Thus, they allow their rich array of quantitative and qualitative sources (most of which were generated by the Cuban government and analysts on the island) to speak for themselves. The result is a disturbing portrait of a government that refuses to grasp the fundamental lessons of policy decisions, even when those decisions planted the seeds of economic decay and overall impoverishment in the very behaviors and resistance of citizens whose labor and attitudes it sought to control. Through a detailed, chronological synthesis covering the period 1959-2006, the authors demonstrate how often the "political logic [of maintaining a monopoly on rule] prevailed over economic logic, even if it resulted in deterioration of economic and living standards" (25).Specifically, Mesa-Lago and Perez-Lopez prove that new rules governing the most essential aspects of life in Cuba reflect an extraordinary degree of consistency with regard to purpose, goals, and outcome, if not the methods and justifications, adopted by the revolutionary elite over the past fifty years. Repeatedly, Cuba's leaders have entangled development in a dizzying back-andforth cycle of adopting what the authors call "idealistic" (anti-market) policies that shored up political stability by reducing or entirely eliminating citizens' economic autonomy from the state to induce loyalty and periodic turns to "pragmatist" (market-oriented) strategies. The latter happened whenever the idealist approach failed and economic conditions reached a critical stage or provoked intense popular discontent (11-24). As Mesa-Lago and Perez-Lopez recognize, the unexpected ascent of Raul Castro to the pinnacle of authority was greeted by a rising tide of hopeful expectations. Raul himself buoyed this reaction by calling for feedback from state enterprises and agencies through mass meetings meant to generate lists of perceived problems and possible solutions. Public response was electric. From October to December 2007, five million citizens presented more than one million suggestions over the course of 215,687 assemblies (172). Yet Raul Castro's characterization of the meetings' goals, as well as his own advisers' interpretations of results, was deeply emblematic of how the revolutionary state has traditionally incorporated and reacted to critiques from below: "[T]he purpose of the meetings was not for us to learn about problems; we were already aware of most of them . . . [and] some of the suggestions reflect a lack of information, particularly those in the economic sphere" (Raul Castro, quoted at 173). …


Phosphorus (P) availability in highly weathered soils is limited. The objective of this study was to determine the effects of poultry manure (PM) and lime on P availability in humic soils. The soils were amended with lime and PM, separately and in combination, and incubated at field capacity moisture in a dark room at 25 °C. Destructive sampling was done after 0, 7, 14, 21, 28, 42, 56 and 84 days and analyzed for extractable P. Soil microbial biomass phosphorus (SMB-P) was analyzed at days 14, 28 and 84 while other soil P fractions were determined after day 84 only. The PM alone had significantly higher extractable P than lime alone and co-application, and some mineralized P from PM was fixed with no contribution of resident soil organic matter (SOM). Higher P availability was observed at 0–10 cm than at 10–20 cm depth. Application of PM and lime increased P availability and SMB-P and decreased Al-P and Fe-P. The SMB-P decreased with increased incubation time in all treatments. These findings imply that the addition of PM and lime increase P availability and SMB-P, reduce fixation of P in humic soils, and that PM addition reduces contribution of resident SOM to available P.


Significance Usually diagnosed in young men, testicular germ cell tumors (TGCTs) originate from abnormalities in germ cells during fetal development. Testicular cancer is a complex disease combining multiple genetic variants and environmental factors. The discovery of unconventional inheritance for TGCT risk both in humans and mice highlighted the major contribution of epigenetic mechanisms. The current work identifies two TGCT modifiers, the RNA-binding proteins apolipoprotein B mRNA-editing enzyme complex 1 (APOBEC1) complementation factor (A1CF) and Argonaute 2 (AGO2), respectively involved in RNA editing and RNA silencing. These results help us better understand the epigenetic control of germ-cell fate, urogenital development, and gamete functions. Testicular tumors, the most common cancer in young men, arise from abnormalities in germ cells during fetal development. Unconventional inheritance for testicular germ cell tumor (TGCT) risk both in humans and mice implicates epigenetic mechanisms. Apolipoprotein B mRNA-editing enzyme complex 1 (APOBEC1) cytidine deaminase and Deadend-1, which are involved in C-to-U RNA editing and microRNA-dependent mRNA silencing, respectively, are potent epigenetic modifiers of TGCT susceptibility in the genetically predisposed 129/Sv inbred mouse strain. Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners. In addition, non-Mendelian inheritance was found among progeny of A1cf and Ago2 mutant intercrosses but not in backcrosses and without fetal loss. Together these findings suggest nonrandom union of gametes rather than meiotic drive or preferential lethality. Finally, this survey also suggested that A1CF contributes to long-term reproductive performance. These results directly implicate the RNA-binding proteins A1CF and AGO2 in the epigenetic control of germ-cell fate, urogenital development, and gamete functions.


STUDY DESIGN
Prospective cohort study.

OBJECTIVES
To report the results for an alternative technique based on minimally invasive fusion-less surgery. This approach is original in that it corrects deformities by proximal and distal fixation, with reliable pelvic fixation through the use of iliosacral screws on osteoporotic bones.

METHODS
Adult cerebral palsy patients requiring spinal correction surgery were included prospectively between 2015 and 2019. The technique involved the use of a double-rod construct anchored proximally by four clawed hooks and distally by iliosacral screws, in a minimally invasive approach. Cobb angle and pelvic obliquity were measured before and after initial surgery and at final follow-up. Complications and functional results were reviewed. This group (P) was compared with a second group (R) of patients who underwent surgery between 2005 and 2015, for whom data were collected retrospectively.

RESULTS
Thirty-one patients were included in group P, and 15 in group R. The two groups were comparable for demographic data and deformity. At most recent follow-up (3 years for group P [2-6] and 5 years for group R [2-16]), neither correction nor surgical complications differed between the two groups. However, group P had 50% less blood loss and a lower medical complication rate than group R.

CONCLUSIONS
Our results confirm the effectiveness of this minimally invasive technique for neuromuscular scoliosis in adults. The results were similar to those obtained with the usual techniques, but with fewer medical complications. Confirmation of these results is now required for a longer follow-up period.


Abstract Syndromes of acute mountain sickness share hypoxia as a cause, but expression of the illness varies. Cerebral edema is a cause for the development of headache, selective neurologic defect,...


24 Recombinant adenovirus serotype 5 (Ad5) vectors are promising vaccine 25 candidates due to their intrinsic immunogenicity and potent transgene expression, 26 however, widespread pre-existing Ad5 immunity has been considered a developmental 27 impediment to the use of traditional, first-generation (Ad5[E1-]) vaccines. Even in the 28 presence of anti-Ad5 immunity, recent murine and human studies have confirmed E2b- 29 deleted Ad5 (Ad5[E1-,E2b-]) vaccines to be highly efficacious inducers of transgene- 30 specific memory responses and significantly less toxic options than Ad5[E1-] vaccines. 31 While these findings have been substantially confirmed, the molecular mechanisms 32 underlying the different reactions to these vaccine platforms are unknown. Using 33 peripheral blood mononuclear cell (hPBMC) cultures derived from multiple human 34 donors, we found that Ad5[E1-,E2b-] vaccines trigger higher levels of hPBMC pro- 35 inflammatory cytokine secretion than Ad5[E1-] vaccines. Interestingly, these responses 36 were generated regardless of the donors' pre-existing anti-Ad5 humoral and cell- 37 mediated immune response status. In vitro hPBMC infection with the Ad5[E1-,E2b-] 38 vaccine also provoked greater levels of Th1-dominant gene responses, yet lower 39 amounts of Ad viral-derived gene expression as compared to Ad5[E1-] vaccines. These 40 results suggest that Ad5[E1-,E2b-], in contrast to Ad5[E1-], vaccines do not promote 41 activities that suppress innate immune signaling, thereby allowing for an improved 42 vaccine efficacy and superior safety profile independent of previous Ad5 immunity. differences in immune-related gene expression were found to peak at six hours post- 93 infection (hpi) (35). Acknowledging that further viral gene deletions within recombinant 94 Ad5 vaccines can change immune reactions towards them, we measured levels of viral 95 and host gene expression, as well as infection-induced cytokine secretion, from multiple 96 independent samples of human peripheral blood mononuclear cells (hPBMCs) early 97 after Ad5[E1-] or Ad5[E1-,E2b-] infection. The results of these studies suggest that the 98 improved therapeutic value of Ad5[E1-,E2b-] over first-generation recombinant Ad5 99 vaccines may be due to differential activation of the innate immune response. No Ad5[E1-]- Ad5[E1-,E2b-]- induced secretion of IL-6 from hPBMCs however, both higher levels of IL-6 production than mock infection. these findings suggest that Ad5[E1- ,E2b] hPBMC infection may illicit a stronger, early pro-inflammatory cytokine response than an Ad5[E1-] vaccine platform; an observation that is consistent across several subjects' The obtained produced hPBMCs


G. Shen, D. H. Zhang, M. C. Wu, Q. Xu, Q. H. Qi: College of Materials and Metallurgy, University of Science and Technology Liaoning, Anshan City, China The ladle bottom argon blowing process has an important influence on the refining liquid steel. The effects of diameters, insertion depth of immersed cylinder and bottom gas flow rate on the flow state of liquid steel and the amplitude of liquid steel surface are numerically simulated for 150t ladle. The results show that the slag entrapment of liquid steel surface can be confined by changing the diameters and insertion depths of immersed cylinder. The effects of gas flow rate, diameter and insertion depth with immersed cylinder on the flow of molten steel in the ladle were analyzed.


Graphology is an experimental science which reveals, by studying the natural graphic movement of the subject, his personality, temper, intellectual behavior, professional and social capacities and his morbid inner predispositions. The product of such a niche analysis is a psychosocialbehavioral portrait, which resembles those of psychologists, focusing only on the interaction between the biological and psychic components reflected in people's handwriting. It can be used, should the case allow it, as a very resourceful and coherent profiling instrument, meant to complete and enhance the information highlighted by forensic psychologists and psychiatrists, and it can also be of assistance to investigators in their interrogation activities, regardless it involves the suspect, victim or witnesses.


Electrical properties and microstructures of Au/Pt/Ti/Ni ohmic contacts to p‐type ZnTe were investigated using the transmission line model method and cross‐sectional transmission electron microscopy. The specific contact resistance decreases when the annealing temperature is increased and reaches a minimum at 300 °C. The formation of NiTe2 from the reaction between Ni and ZnTe plays an important role in lowering the contact resistance. A contact stability test performed at 102 °C suggests that these ohmic contacts are stable even under high‐current injection.


Financial crises cause economic, social and political havoc. Macroprudential policies are gaining traction but are still severely under-researched compared to monetary policy and fiscal policy. We use the general framework of sequential predictions also called online machine learning to forecast crises out-of-sample. Our methodology is based on model averaging and is meta-statistic since we can incorporate any predictive model of crises in our set of experts and test its ability to add information. We are able to predict systemic financial crises twelve quarters ahead out-of-sample with high signal-to-noise ratio in most cases. We analyse which experts provide the most information for our predictions at each point in time and for each country, allowing us to gain some insights into economic mechanisms underlying the building of risk in economies.


A brief overview of nuclear data required for medical applications is given. The major emphasis is on radionuclides for internal applications, both for diagnosis and therapy. The status of the presently available data is discussed and some of the emerging needs are outlined. Most of the needs are associated with the development of non-standard positron emitters and novel therapeutic radionuclides. Some new developments in application of radionuclides, e.g. theranostic approach, multimode imaging, radionanoparticles, etc. are described and the related nuclear data needs are discussed. The possible use of newer irradiation technologies for medical radionuclide production, e.g. intermediate energy charged-particle accelerators, high-power electron accelerators for photon production, and spallation neutron sources, will place heavy demands on nuclear data.