want to consider in this essay how Adrienne Rich has used poetic figuration of monuments to envision her subjects and readers as active contributors to contemporary American national identity. Since the 1980s, Rich has applied the core feminist concerns of her work to the lives of a range of men and women across geographic, ethnic, and religious boundaries. Rich's poetry of testimony to these lives-especially those marked by dislocation and violence-has attempted to be politically instrumental, spurring action both among those who are represented in her work and among her readers. The force of this poetry, Cynthia Hogue has argued, lies in Rich's power to connect her readers and subjects across the boundary of the text: "By transporting the reader from outside to inside the poem, [Rich's] poem's import is potentially translated from inside to outside the textual frame" ("Subject" 414). These crossover effects are particularly suited to Rich's recent interest in national identity, which as she sees it is created at the juncture of the history of a place and the social and political concerns of a given moment. To produce these effects on public selfunderstanding in a way that transcends the textual frame, Rich often turns to inspirations outside of textual forms, including photography, painting, and, most prominently, monuments. By taking the monument as her aesthetic model, Rich exposes herself to charges


The article covers the basic concepts of artistic photo composition, the general purpose of the composition, the artist's use of visual and expressive means of this art, the use of specific methods and techniques of constructive construction.


A contribution to the knowledge of carabid beetles in the subbetic moutztains (Cordobn. Spain). Carabid species caught in the subbetic mountains located in the southern part of the pro- vince of Cordoba (SW Iberian Peninsula) are reported in this paper. The faunistic results confirm the presence in the area of Ophonus (Methophonus) melleti (previously only found in the nort- heastern part of Spain) and Acinopus giganreus.


Utilizing suggestions from clinicians and administrative staff is associated with process and quality improvement, organizational climate that promotes patient safety, and added capacity for learni...


Most programming languages or modeling systems use either sequential control or, in the other extreme, complete concurrency. We propose here a control structure consisting essentially of dynamic priority relations between elementary steps. Elementary steps may be executed if they are "enabled" executable and if at that time no other elementary step with a higher priority is enabled. This leaves much room for concurrency. Priorities can be changed after executing a step. Such a control structure can be imposed on Petri nets; this has been investigated more closely for the modeling language MoMo i.e., for its task layer , which is based on colored Petri nets. The proposed task layer language is presented here in some detail. It has been tried out with several medium-size examples selected to find out to which limits this control principle is feasible. Few priorities have been


In operation of equipment, many components are subjected to the effect of the abrasive medium. In the absence of accompanying impact loading, this type of effect is strongly resisted by the deposited metal with the structure of chromium cast-iron, additionally alloyed with boron (up to 1–1.5%). Electrodes T-590 and T-620 are widely used in surfacing. However, the accompanying impact loading of even low intensity greatly reduces the efficiency of application of these electrodes because of the chipping of the working layer. In addition to this, surfacing with these electrodes (if the number of layers is greater than 2) is also associated with the chipping of the working layer without any effect of the working load. According to the authors, for hardfacing of components subjected to abrasive and impact-abrasive loading, it is promising to use materials which harden under the effect of working load since the abrasive wear resistance of the hardfacing materials is ensured in accordance with the principle of metastability of austenite in order to ensure the required contact strength. For example, the deposited metal (Patent 2171165, Russian Federation) alloyed with carbon (up to 1.5%), chromium (up to 8%) and titanium (up to 3%), capable of rapid hardening under the effect of working loading with the formation, from the unstable austenitic condition, of the alpha martensite in deformation, showed in abrasive wear in the conditions of friction with a secured specimen almost the same resistance as the metal deposited with the T-590 electrodes. The advantage of the deposited metal of this composition is the possibility of surfacing of more than three layers without any risk of spallation. However, to increase the abrasive resistance, it is efficient to alloy additionally the deposited metal with boron up to 0.2–0.5%. The presence of the carbide–boride eutectic at the austenite grain boundaries greatly complicates the occurrence of plastic deformation and, consequently, reduces the rate of wear. In addition to this, according to the experimental results, the addition of boron in the given range greatly intensifies the process of transfer of titanium from the coating into the deposited metal. Materials with a similar composition of the deposited metal (powder wire PP-Np-150Kh6T4M) have been developed at the E O Paton Electric Welding Institute. The wear resistance of the deposited metal was evaluated using the generally accepted procedure of wear testing using a secured specimen in special equipment based on a milling machine. The specimens with the area of the working section of 10 × 10 mm moved by translation movement on 14A32MN481 grinding paper (GOST 645682) based on corundum. The length of the single working stroke of the specimen was 0.13 m. The friction path of the specimen in the single test at a speed of movement of 0.158 m/s was 78 m. The normal load, acting on the specimen, was 10 N (specific load 0.1 MPa). The transverse displacement of grinding paper in a single and double stroke of the specimen was 1.2 mm. Abrasive wear resistance was determined from the results of three parallel tests (reference material steel 110G13L), and the results were compared on the basis of the relative units:


Field application vectors (FAVs), whichare a combination ofa selective substrate, a host, anda cloning vector, havebeendeveloped forthepurposeofexpressing foreign genesinnonsterile, competitive environments inwhichthegene products provide no advantage tothehost.Suchgene products are exemplified bythe enzymesforthecometabolism ofpolychlorinated biphenyls (PCBs) through thebiphenyl degradation pathway. Attempts tousehighly competent PCB-cometabolizing strains intheenvironment intheabsence ofbiphenyl havenotbeensuccessful, whiletheaddition ofbiphenyl islimited byitshumantoxicity andlowwater solubility. Broad-substrate-specificity PCB-degradative genes(bphABC) were cloned froma naturally occurringisolate, Pseudomonas sp. strain ENV307,intobroad-host-range plasmidpRK293.The resulting PCB-degrading plasmids were transferred totheFAVhost Pseudomonas paucimobilis IIGP4, whichutilizes the nontoxic, water-soluble, nonionic surfactant Igepal CO-720 asaselective growthsubstrate. Plasmid stability in therecombinant strains was determined intheabsence ofantibiotic selection. PCB-degrading activity was determined byresting cell assays.Treatment ofcontaminated soil (10, 100, or1,000 ppm ofAroclor 1242) by surfactant amendment (1.0%[wt/wtlIgepal CO-720inwetsoil) andinoculation withrecombinant isolates of strain 1IGP4(approximately 4x 106cells pergofsoil) resulted indegradation ofmany oftheindividual PCB congenersintheabsence ofbiphenyl. Further improvements, including theuse ofnon-antibiotic-resistance cloning vectors, addition ofthebphDgene,andchromosomal integration ofthePCB-degradative genes,may ultimately result inFAVsuseful forbothreactor-contained andinsitu treatment ofthepartially dechlorinated PCBsoften foundincontaminated soils andsediments. Manypotential applications ofgenetically engineered microorganisms inenvironmental biotechnology involve introducing genetic capabilities intononsterile, competitive environmentsinwhichthegenetic capabilities provide no advantage tothehost. Thisisexemplified bythecometabolismofpolychlorinated biphenyls (PCBs) through thebiphenyldegradation pathway. PCBcontamination iswidespread as a result ofindustrial activities. Thehighly chlorinated congenersincommonlyusedAroclors (commercial PCB mixtures) arepersistent inaerobic environments. Workershaveisolated many strains ofmicroorganisms whichgrow on biphenyl as a solesource ofcarbonand energy andcometabolize many ofthePCB congeners presentincommercial Aroclors (3,13).Degradation is mediated byfourenzymes encodedbythebphABCDgenes, whichconvertchlorobiphenyls totheir corresponding chlorobenzoic acids(12,23).Theseorganisms are unableto dehalogenate theresulting ring fission products andcannot use any ofthehighly chlorinated congenersas growth substrates (1,13). However, otherorganisms arecapable of dehalogenating andmineralizing chlorobenzoic acids(24). Therate-limiting stepinthemetabolism ofPCBstoCO2in theenvironment hasbeenreported tobetheinitial cometabolic oxidation (11). Following stimulation ofcometabolic activity viabiphenyl amendment, transient accumulations of chlorobenzoic acids havebeenobserved, andmany ofthese


The role of one-dimensional (1-D) digital finite impulse response (FIR) lossless matrices in the design of FIR perfect reconstruction quadrature mirror filter (QMF) banks has been explored previously. Structures which can realize the complete family of FIR lossless transfer matrices, have also been developed, with QMF application in mind. For the case of 2-D QMF banks, the same concept of lossless polyphase matrix has been used to obtain perfect reconstruction. However, the problem of finding a structure to cover all 2-D FIR lossless matrices of a given degree has not been solved. Progress in this direction is reported. A structure which completely covers a well-defined subclass of 2-D digital FIR lossless matrices is obtained. >


The article deals with the activities of a psychologist-educator and his role in relation to the problem of student deviation in the digitalisation context and the widespread use of the Internet. A comprehensive analysis of adolescent deviations and various aspects of dealing with students' destructive behavior and with their parents using knowledge from different subject areas – law, sociology, psychology, medicine, pedagogy, has been conducted. The features and characteristics of adolescence are considered, and the factors influencing the formation of deviant behavior, including medical ones, are identified. The role of the educational organisation's psychologist in identifying and correcting learners behavior destructive forms is outlined. The necessary ratio between the staff of psychologists and medical specialists and the students number in educational organisations is given. As a result of the analysis of the current legislation, the shortcomings of certain legal provisions and the need to change them in destructive behavior prevention part were noted. Recommendations for professionals in the helping professions have been developed and projected positive results of the outlined activities have been given. The authors' conceptual findings are applicable to creating a safe and supportive environment for learners, reducing juvenile delinquency and amending legislation.


This letter presents a terahertz(THz) multiplier by four using two-stage push-push structure [1]. An 80 GHz Balun and a 160 GHz Balun are implemented by Marchand Balun structure and good performance of amplitude balance and phase balance are achieved as well as low insertion loss. The simulation results show that the output 3dB bandwidth is 70 GHz ranging from 270 GHz to 340 GHz. The quadruapler has a frequency conversion loss less than 13 dB. At the same time, good fundamental rejection greater than 30 dB and low DC power consumption 8 mW are achieved. The whole circuit is designed on 40 nm CMOS technology and occupies area of $\pmb{710 \mu\text{m} \times 400\mu \text{m}}$ including pads.


Human translation process research analyzes the translation behavior of translators, such as memory and search strategies to solve translation problems, types of units that translators focus on, etc., identifies the temporal (and/or contextual) structure of those activities, and describes interand intra-personal variation. Various models have been developed that explain translators' behavior in terms of controlled and uncontrolled workspaces and with microand macro-translation strategies. However, only a few attempts have been made to ground and quantify translation process models in empirical user activity data. In order to close this gap, this chapter outlines a computational framework for a cognitive model of human translation. The authors investigate the structure of the translators' keystrokes and gaze data, discuss possibilities for their classification and visualization, and explain how a translation model can be grounded and trained on the empirical data. The insight gained from such a computational translation model not only enlarges our knowledge about human translation processes, but also has the potential to enhance the design of interactive MT systems and help interpret user activity data in human-MT system interaction. DOI: 10.4018/978-1-4666-2169-5.ch005


6588 Background: Clofarabine, a next-generation nucleoside analogue, has shown clinical activity when used as a single agent in heavily pretreated patients with relapsed or refractory acute leukemias. The results of two Phase 2 multicenter, open-label studies with clofarabine in children with refractory or relapsed ALL or AML are presented here. Methods: Clofarabine was administered at 52 mg/m2 given by intravenous infusion over 2 hours daily over 5 consecutive days. Cycles were repeated every 2 to 6 weeks based on response and toxicity. Results: 103 patients (61 ALL, 42 AML) have been treated. Patients on the ALL trial had received a median of 3 prior regimens (range 2–6). Thirty percent had received prior transplant. As determined by independent review, preliminary data indicate overall response rates of 30% in ALL (7 CR, 5 CRp, and 6 PR). Median duration of CR/CRp is 29 weeks. On the AML trial, median age was 12 years (range 2–22). Median number of prior regimens was 2 (range 1–5). Forty three percent ...


This paper traces out the general trajectory over the last twenty years of the New Approaches to International Law movement (a.k.a. the Newstream) in institutional, ideological, and ideational terms.


A model for simulating the DC characteristics of the gate junction in High Electron Mobility Transistors is presented. The equations for the gate current of FET's in the SPICE simulator are modified to account of the HEMT gate current in a wide range of bias conditions. It is proven that a four-diodes model yields to a satisfactory agreement with the experimental data. The presented model can be employed either by implementing the modified equations in the simulator code or by a device macro modeling.


This paper describes transferability analyses of multimodal mode choice models to conduct travel demand forecasting for major metropolitan areas in the State of Oklahoma in USA. The transferred mode choice models were initially calibrated and validated to reflect travel characteristics of multimodal nature in the metropolitan area of Austin in Texas. The multimodal mode choice models used in patronage forecasting are of logit type comprising six modes for home-based work (HBW) trips and seven modes for home-based other (HBO) and non-home-based (NHB) trips. The mode choice model system calls for person trip tables to be partitioned by mode of access/egress to/from a transit line. (A)


The present invention relates to an injector nozzle defining a passage for a flow of reactants to be injected into a loop reactor suitable for olefin slurry polymerization, consisting essentially of afluid conduit extending into a discharge orifice portion to be connected to an opening in the reactor wherein the passage of the discharge orifice portion has a non-circular cross-section and the passage of the fluid conduit has a circular cross-section. The invention also relates to the use of an injector nozzle for injecting reactants into a loop reactor suitable for olefin polymerization reaction, wherein said injector nozzle is connected on an inner three quarter circle on or above an elbow section of the reactor.


This article considers the types of institutional organizations and their influence on the regional economy. Keywords: innovative organizations, regional economy, innovative environment.


Ammonia, the third most important abundant nitrogen compound, is a primary alkaline gas in the atmosphere. It has strong absorption bands in the deep ultraviolet (DUV) spectral range and so can be reliably detected by the differential optical absorption spectroscopy (DOAS) technique. A portable UV-DOAS gas sensor based on multi-pass cell has been designed to detected trace gases, especially for ammonia, in the DUV spectral range, with good performance using a broad-band Deuterium source and high-sensitivity spectrometer. With the optical path as long as 20m, such a sensor could detected NH3 concentrations as low as 100ppb according to the result of in-situ measurement. Fast response time and low measurement error of this portable gas sensor could be competent for emergency monitoring.


The ternary compound Ce 2 PdGe 6 exhibits antiferromagnetic ordering below the temperature 11.4 ′ 0.2 K, as revealed in the electrical-resistivity, static magnetic susceptibility, and low-temperature specific-heat data. The entropy associated with the magnetic structure of Ce 2 PdGe 6 was found to be close to the theoretical value of 2R In 2, which would be expected for a doublet ground state of Ce + 3 ions in the compound Ce 2 PdGe 6 . The magnetic contribution to the heat capacity of Ce 2 PdGe 6 below Neel temperature T N was found to depend on the cube of temperature, which furnishes perhaps the most direct experimental testimony of the whole spin-wave theory for an antiferromagnetic material.


The mathematical model of its optimal design for the gear transmission case of Xiangyuan--AQG plough-and-harrow cultivator was developed,to save its raw materials,reduce the weight,cut down the expenses and improve its performances.Under the required condition for the transmission ratio,power and relevant usage of the gear transmission case,this model can be used to produce optimum production process and more reasonable parameters for the case so that its total cost reaches the lowest level.Based on the results produced by the model,improvements are made on the design and production of the gear transmission case.The results indicate that the improved case reduces weight by 25% and cost by 10 % ~ 26.3% in comparison with the original one.


In this paper, we use the brightness temperature data of the Chinese stationary meteorological satellite and wavelet transform and power spectrum estimation methods to investigate the thermal infrared anomalies of these three greater than M S4.5 earthquakes in Songyuan area around 2017. The results show that the anomalies gradually expanded along the strike of Yilan-Yitong fault and Mishan-Dunhua fault zone before the M S4.9 earthquake on July 23, 2017 and the M S 5.7 earthquake on May 28, 2018. The anomalies existed in the eastern margin of the Songliao Basin, but the epicenter of the earthquake was not in that area. The abnormality was not obvious before the M S5.1 earthquake on May 18, 2019. It is a possibility that greenhouse gases, such as CO2 and CH4, were released in the greatest amount in the basin, before and after the previous two earthquakes.


In The Tempest, act II scene i, when Sebastian with the help of Antonio dares to accuse King Alonso, foreshadowing the later regicide attempt, Gonzalo abruptly reveals his Utopian ideas concerning the "commonwealth" he would create on the isolated island. This paper argues that Gonzalo's speech on the commonwealth is a direct criticism of the German Anabaptists, widely known for their violent uprising of 1534 at MUnster in Westphalia. The Anabaptists, with their doctrine of a classless communist society, were also notorious throughout Europe for their polygamy and promiscuity at Munster. The doctrine of the Anabaptists and Gonzalo's theory of a commonwealth are analogical, as Shakespeare's contemporaries must have recognized. The commonwealth passage is based on Montaigne's "Of the Cannibals," in which the author privileges a primitivistic view over one that upholds social law and custom. But Gonzalo (and Shakespeare) shows his orthodox Renaissance belief by making his own speech self-contradictory and humorous, teasing the hierarchy breakers.


Han Dynasty is an important period in which the selection system of talented people had been set up, especially the appointment system made a great contribution to the selection of people of both ability and integrity, which had a tremendous influence on the consolidation and unification of Han Dynasty. As a main way in the selection system at that time, in spite of some drawbacks, the appointment system is undoubtedly progressive.


Ion temperature and variations during discharge were measured using Doppler broadening. Measurements of D/sub BETA /, C III, and He II, were made using the Tokamak installation. Oscillograms for various discharge times and temperatures are included. (R.V.J.)


If the uterine cavity is improperly or inaccurately measured during use of the Hologic NovaSure endometrial ablation system, it could result in thermal or perforation injuries. This article describes some of these injuries and offers guidance on reducing their likelihood.


We consider a real analytic family of area-preserving maps on C2, fµ, depending analytically on the parameter, such that f0 is a map at 1:3 resonance. Such maps can be formally embedded in an one degree of freedom Hamiltonian system, called the normal form of the map. We denote the third iterate of the map by Fµ = f3µ.

We show that given a certain non degeneracy condition on the map F0, there exists a Stokes constant, θ, that when it does not vanish, it describes the splitting of the separatrices that the normal form predicts. We show that this constant can be approximated numerically for any non-degenerate map F0.

For a non-vanishing and small enough µ, we show that if the Stokes constant does not vanish the separatrices split. Moreover, let Ω be the area of the parallelogram defined by the 2 vectors tangent at the two separatrices at a homoclinic point. For any M e N we have the estimate.

In this equation λµ is the largest eigenvalue of the saddle points around the origin and θn's are real constants with θ0 = 4π|θ|.


We demonstrate angle-insensitive spectral imaging in the wavelength range of 400 to 800 nm for average polarization based on topology-optimized plasmonic metasurfaces by optimizing the period and shape of the meta-atom.


Abstract The chemical composition of the essential oils from fresh leaves of four species (Artemisia sodiroi, Siparuna eggersii, Tagetes filifolia and Clinopodium nubigenum), grown wild in the southern Ecuador (province of Loja), was examined through the GC-MS analysis. In the essential oil of A. sodiroi, the oxygenated monoterpenes were the main group of components, especially sabinyl acetate (65.8 %), while the essential oil of S. eggersii was mainly composed by the oxygenated sesquiterpenes among which the epicurzerenone (29.9 %) was the most representative. Conversely, the aromatic hydrocarbons predominated in the oils of T. filifolia and C. nubigenum, with (E)-anethole (72.6 %) and carvacryl acetate (38.1 %) as the main components, respectively.


This article was written inside the New York City "Tombs" or Men's House of Detention, where the author had been remanded without bail, while awaiting sentencing on charges of criminal contempt. Mr. McAdoo, who is chairman of CERGE (see MR, January, 1965, inside back cover) and a leader of the Harlem Defense Council, was convicted along with four others on March 22, on several counts of criminal contempt of the 2nd August Grand Jury which is "investigating" the causes of last summer's Harlem "riots." The five jailed on March 22 have a total of eight children. The procedure of remanding persons to prison without bail, pending sentencing, on a misdemeanor charge, is unusual if not unique in New York law. The five received their sentences on April 5 and as we go to press they are still in jail, while their attorneys appeal the convictions. The five are: William McAdoo, David Douglas, Vivian Anderson, Nat Barnett, and Mike Crenovich. —The EditorsThis article can also be found at the Monthly Review website, where most recent articles are published in full.Click here to purchase a PDF version of this article at the Monthly Review website.


Nanostructured catalysts AB2O4 spinel type oxides (A = Co and B = Cu) were prepared by the sol-gel self-combustion method using citric acid as precursor. They were characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Catalytic activity tests, which have proven to be effective for selective catalytic reduction of NOx using hydrocarbon as a reducing agent (SCR-HC) in a temperature range 250 - 450 ° C, reaching up to 40% conversion of NO and 100% selectivity towards the formation of N2


When the film thickness is considered as a parameter, a system composed of a transparent film on an absorbing substrate (in a transparent ambient) is characterized by a range of principal angle ϕ¯min⩽ϕ¯⩽ϕ¯max over which the associated principal azimuth ψ¯ varies between 0° and 90° (i.e., 0°⩽ψ¯⩽90°) and the reflection phase difference Δ assumes either one of the two values: +π/2 or −π/2. We determine the principal angle ϕ¯(d) and principal azimuth ψ¯(d) as functions of film thickness d for the vacuum-SiO2-Si system at several wavelengths as a concrete example. When the film thickness exceeds a certain minimum value, more than one principal angle becomes possible, as can be predicted by a simple graphical construction. We apply the results to principal-angle ellipsometry (PAE) of film-substrate systems; the relationship between ϕ¯ and ψ¯ during film growth is particularly interesting.


Quantitative evaluations are necessary when discussing accuracy. Reply: Thanks for your suggestion. Quantitative improvements for M2 and K1 are briefly supplemented in the abstract: "It significantly reduces the total errors of eight tidal constituents (with the exception of N2 and Q1) in the traditional explicit tidal scheme, in which the total errors of K1 and M2 are reduced by 21.85% and 32.13%, respectively." in Line 29-31. "Compared with Exp1, the total errors of K1 and M2 in Exp2 are reduced by 21.85% and 32.13% respectively." in Line 268-269. and arbitrary on the


We recently reported molecular dynamics simulations of the two native forms of crystalline cellulose [A. P. Heiner, J. Sugiyama and 0. Teleman, Carbohydr. Res., in press]. From these a number of molecular properties have been calculated and show that local structure differs in triclinic and monoclinic cellulose, but also between the so-called odd and even subphases of monoclinic cellulose. Although all glucose rings remain close to the 4C1 chair conformation, pucker analysis shows that the odd subphase tends towards the 2E envelope. Literature data were systematised into a relation between certain torsion angles and solid state l3C NMR chemical shifts. Torsion angles were found to be important for the C-6 chemical shift but not for the C-1 and C-4 carbn atoms.


Background Nilotinib has shown superiority over imatinib for treating pts with newly diagnosed CML-CP. Additionally, pts who are resistant or intolerant to imatinib can often achieve improved responses by switching to nilotinib. However, the value of switching pts to nilotinib due to molecular SoR on imatinib is not well characterized. The Study to Evaluate Nilotinib in CML pts with SubOptimal Response (SENSOR) was therefore conducted to evaluate the efficacy and safety of nilotinib 400 mg BID in pts with CML-CP with SoR to frontline imatinib. Here, we present results of a planned 12-mo interim analysis.

Methods SENSOR ([NCT01043874][1]) is an open-label, multicenter, phase IV study. Adult pts with CML-CP in complete cytogenetic response but not in major molecular response (MMR; defined as BCR-ABL ≤ 0.1% on the International Scale [IS]) after ≥ 18 mo on frontline imatinib (SoR as defined by 2009 European LeukemiaNet criteria) were eligible to enroll and switch to nilotinib 400 mg BID. Molecular responses were assessed prior to enrollment, at 1, 2, and 3 mo and every 3 mo thereafter. Mutational analyses were performed at baseline (BL) and at end of study in all pts, every 3 mo in pts with BL mutations, and with any ≥ 5-fold increase in BCR-ABL from the lowest level in pts not in MMR. All of these assays were done at a single central laboratory. The primary endpoint was the rate of MMR at 12 mo. Planned enrollment was 45 pts in order to provide a ≥ 25% lower limit of the 95% CI with an expected MMR rate of 40%. Planned follow-up was 24 mo.

Results Planned enrollment of 45 pts was completed between Dec 2009 and Feb 2012. Median age of pts was 47 years (range, 19-80). Pts had received imatinib for a median of 23.0 mo (range, 17.0-103.3) at a median daily dose of 400 mg (range, 297-628). Median BL BCR-ABL/ABL ratio was 0.24% (range, 0.11-3.49). At the cutoff date, 19 pts (42%) had completed the study (24 mo follow-up), and 21 (47%) had nilotinib treatment ongoing. Median nilotinib duration was 19.1 mo (range, 0.1-22.7) and median dose intensity was 733 mg/day (range, 183-800). Five (11%) pts discontinued from study treatment for the following reasons: adverse events (AEs; n = 2), disease progression (n = 1), withdrawal of consent (n = 1), and administrative problems (n = 1).

At 12 mo, the MMR rate was 51.1% and the median BCR-ABL/ABL ratio was 0.10% (range, ≤ 0.0032-1.62). The cumulative rate of MMR by 12 mo was 66.7%. Among 34 pts with MMR at any time, median time to first MMR was 2.28 mo. No pt who achieved MMR had confirmed loss of MMR (BCR-ABLIS > 0.1% with a ≥ 5-fold increase in BCR-ABL transcripts from the lowest level achieved on study in 2 consecutive samples) by the cutoff date ([Table][2]). Two pts (4.4%) achieved BCR-ABLIS ≤ 0.0032% at 12 mo.

View this table:

Table 1

BCR-ABL mutations were detected at BL in 5 pts (E255K, E459K + exon 8/9 35 base pair insertion, Q252R, M244V, and exon 7 deletion), all of whom achieved MMR on nilotinib. Mutations were identified during treatment in 13 pts, 2 of whom had the same mutation at BL; 10 of these pts achieved MMR. One pt developed a T315I mutation, progressed at 5.4 mo, and died at 9.4 mo. These were the only reported events for progression-free survival and overall survival (1 each).

The safety profile of nilotinib was consistent with previous studies. Drug-related AEs (any grade) occurring in ≥ 20% of pts included hyperbilirubinemia (53.3%), increased ALT (28.9%), headache (28.9%), hypophosphatemia (26.7%), rash (26.7%), and increased lipase (24.4%). Grade 3/4 newly occurring/worsening abnormal hematology values were hemoglobin (6.7%), neutrophils (4.4%), platelet count (2.2%), and decreased total white blood cells (2.2%). Six pts had serious AEs (2 with suspected relation to study drug [anemia and erythema multiforme]).

Conclusions After switching to nilotinib, MMR was rapidly achieved in the majority of pts. These results support the clinical benefit of switching to nilotinib in pts with molecular SoR to imatinib.

Disclosures: Miyamura: Novartis: Speakers Bureau; JRC Nagoya 1st Hospital: Employment. Miyamoto: Kyushu University Hospital: Employment. Kurokawa: Celgene: Consultancy, Research Funding; Bristol Myers Squibb: Research Funding; Novartis: Consultancy, Research Funding. Yamamoto: Novartis: Honoraria, Research Funding. Taniwaki: Novartis: Honoraria. Kimura: Novartis: Honoraria, Research Funding; BMS: Honoraria, Research Funding. Ohyashiki: Novartis: Honoraria, Research Funding. Kawaguchi: Novartis: Honoraria. Matsumura: Bristol Myers Squibb: Honoraria; Novartis: Consultancy, Honoraria, Research Funding. Tsurumi: Novartis: Honoraria. Hino: Novartis: Research Funding. Tadokoro: Novartis: Guest speaker in a scientific meeting sponsored by Novartis Other. Hyodo: Hiroshima University: Employment. Kubo: Aomori Prefectural Central Hospital: Employment; Novartis: Honoraria. Kondo: Novartis: Employment. Amagasaki: Novartis: Employment. Kawahara: Novartis: Employment. Yanada: Novartis: Consultancy.

 [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01043874&atom=%2Fbloodjournal%2F122%2F21%2F2729.atom
 [2]: #T1


Media Websites often solicit users' comments on content items such as videos, news stories, blog posts, etc. Commenting activity increases user engagement with the sites, by both comment writers and readers, and so sites are looking for ways to increase the volume of comments. This work develops a recommender system aiming to present users with items -- news stories, in our case -- on which they are likely to comment. We combine items' content with a collaborative-filtering approach (utilizing users' co-commenting patterns) in a latent factor modeling framework. Building upon previous work, we focus on a continuous, real-time approach to address the problem above. After an initial training period during which commenting activity of users is observed, the system is tested at each subsequent comment submission event by predicting which story is being commented on by a given user at a given time. Our results show that we are able to overcome the site's inherent presentation bias and outperform a strong baseline as users' commenting history grows.


num bered examples, and there is an index. There are a few p rin ter's errors, " m utliply " (p. 39, 1. 1), " a r e " ( = arc , p. 98, ex. 17), incorrect symbols (p. 88, 1. 12 ; p. 120, ex. 25 ; p. 182, 1. 5 ; p. 264, 1. 3 from bottom ; p. 304: ex. 2). This book goes up to " S " level plus. W ith judicious selection it could be used by a science specialist, while the m athem atical specialist who used it as a first advanced text-book would gain much from it and would have little to un learn . B. A. Sw in d en .


Military's Internet of Things is an application of Internet of Things in the military areas.It is very important for ensuring nation al security and safeguarding state sovereignty.This paper introduces the definition and application directions of Military's Internet of Things,analysis the problem in developing Military's Internet of Things,and provides a strategy for developing Military's Internet of Things.


This paper elaborates the application of the Journal management function of Gold Disk Library Integrated Management System in the process of assisting to bind periodicals.It will shorten the hours of periodicals Bindery and improve the binding quality and increase the utilization ratio of periodicals service.


""Family Fortunes" is a major groundbreaking study that will become a classic in its field. I was fascinated by the information it provided and the argument it established about the role of gender in the construction of middle-class values, family life, and property relations. "The book explores how the middle class constructed its own institutions, material culture and values during the industrial revolution, looking at two settings urban manufacturing Birmingham and rural Essex both centers of active capitalist development. The use of sources is dazzling: family business records, architectural designs, diaries, wills and trusts, newspapers, prescriptive literature, sermons, manuscript census tracts, the papers of philanthropic societies, popular fiction, and poetry. ""Family Fortunes" occupies a place beside Mary Ryan's The Cradle of the Middle Class and Suzanne Lebsock's Free Women of Petersburg. It provides scholars with a definitive study of the middle class in England, and facilitates a comparative perspective on the history of middle-class women, property, and the family." Judith Walkowitz, Johns Hopkins University"


How intermountain trimmed health care costs through robust, making the case for quality improvement the king s fund, evaluation performance management and quality, three principles for improving health care delivery, 4 a community health improvement process improving, assessing quality improvement in health care theory for, improving health care quality the path forward, nqf improving healthcare quality, basics of quality improvement practice management, quality improvement in healthcare online course, improving quality in the english nhs, americans views of health care costs access and quality, how the four principles of health care ethics improve, access to health services healthy people 2020, ten challenges in improving quality in healthcare lessons, issues in measuring and improving health care quality, ihi improving health and health care worldwide, role of quality improvement in strengthening health, the role of nurses in improving hospital quality and, national association for healthcare quality nahq, quality improvement made simple the health foundation, balancing stakeholder needs in the bmj quality amp safety, section 4 ways to approach the quality improvement, importance of quality in health care sector a review, lean six sigma for healthcare quality improvement, health care quality wikipedia, quality improvement methods in health care hastings center, quality initiatives general information cms, continuous quality improvement journal of hospital medicine, six


India is currently one of the fastest growing major economies in the world. Sustaining a high growth rate is believed to be critical for India to alleviate poverty in the country, since it feeds more than a billion people. Energy, being a key enabler of a country's economic growth and development, has witnessed a significant rise in its consumption in India. In 2013 about 528.34 million tons of oil equivalent (Mtoe) were consumed, making India the third largest consumer of energy in the world, more than 70 percent of which is supplied by fossil sources. Increasing energy demand naturally strains the country's resources and impacts the environment. This warrants decoupling the country's economic growth and energy demand. This is also echoed through India's intended nationally determined contribution submitted in the run-up to the Paris Climate Conference, where the government has highlighted energy conservation as a key mitigation strategy. It seeks to achieve total avoided capacity addition of 19,598 MW and fuel savings of around 23 million tons per year through the National Mission for Enhanced Energy Efficiency (NMEEE). However, this requires concerted effort at the central and state levels, especially considering the existing federal governance architecture where many subjects, including electricity, fall under the jurisdictions of both the center and the state.


Abstract Gaining access to resources can be measured in terms of the time spent with, or the number of visits to, a resource. For some resources, time spent with the resource might be more important, for others the number of visits might be more meaningful. By using traverses of shallow water, the costs of gaining access to food, shelter, a conspecific, increased space, a running wheel, deep sawdust, or enrichments (e.g. balls, a variety of small objects) were increased for laboratory mice. When 30 cm of water was present, the number of visits to each resource decreased to 39–64% of the number recorded when no water was present, but the proportion of time spent with each resource was defended. Increasing the width of water to 120 cm had no further effect on the number of visits or on the proportion of time spent with each resource: thus both the frequency of visits and the proportion of time with each resource were ultimately defended. Possible reasons for this change in behavioural organization, including the importance of patrolling, are discussed. The data support previous findings that laboratory mice are highly motivated to patrol areas made accessible to them, and suggest that care is needed when interpreting what animals perceive as reinforcement during visits to resources. Furthermore, it was shown that for laboratory mice under conditions that penalize initial access only, the time spent with a wide variety of resources was defended more diligently than the number of visits, but the number of visits was rarely allowed to decrease to zero.


International law grants states an inherent right to self-defence. States can exercise this right whenever they face armed attack. However, any country wishing to exercise its right to self-defence must fully consider all the restrictions on this right. The right to self-defence can permit the use of force within the borders of the victim state or on the territory of another state from where the attack is carried out. Accordingly, states may respond to any attack by the armed forces of another state or irregular armed groups that use the territory of other states for their attacks. Turkey is a country with a huge population of Kurdish inhabitants. The Kurds possess distinct origins, history, language, culture and a historical link to their land. Thus, they qualify as a people. For much of their history they have peacefully sought to assert their rights; however, Turkey denied those rights to the extent that the formation of the PKK in 1978 became amove of last resort. When the PKK started demanding Kurdish right to self-determination, Turkey launched military operations against it in self-defence. During the 1980s and 1990s, the PKK established camps in Iraq. On several occasions it withdrew its forces there as part of peace negotiations with the Turkish government. Turkey crossed the Iraqi borders and attacked the camps as part of a state policy to fight the PKK outside its borders. The PKK subsequently handed over the camps to other groups, which never posed any military threat to Turkey, but Turkish forces continued to cross the border into Iraq. This article examines the right of Turkey to use force within the borders of Iraq under the justification of self-defence.


In article for the purpose of studying a phenomenon of electronic money available and new functions of money and possibility of their development in the conditions of formation of virtual economy are considered.


The cooperative innovation of full -grown industrial clusters is showing a tendency of self-enhancing.The interactive mecha- nism for cooperative innovation within industrial clusters is analyzed from the static and dynamic views;the cooperative backgrounds and the interactive mechanism in adopting cooperative innovation of enterprises are also discussed from the view of methodology.It is pointed out that long-term innovation system should be formed and local authorities must get involved in the initial stage and secede in later pe- riods.


In this paper, we modernize the seminal Solow's growth accounting methodology towards statistical testing of significance of a contribution from each source of decomposition as well as testing whether such contribution caused a multi-club convergence phenomenon. We illustrate our methodology on the data for developed countries, in attempt to gain some insight on how the three sources of productivity growth—(i) change in ICT-capital per worker, (ii) change in Non-ICTcapital per worker, and (iii) change in TFP—have impacted the distribution of labor productivity in developed countries from 1980 to 1995.


This document provides a procedure for performing operability testing of the Rotary Mode Core Sampling System Exhausters 3 & 4. Upon completion of testing activities an operability testing report will be issued.


The gut microbiome changes with age, and rapamycin treatment both delays aging and modulates the microbiome. This raises important questions concerning cause-effect relationships between microbiome, mTOR signaling and aging mechanisms. Microbiome metabolite valerobetaine (VB) disrupts mitochondrial fatty acid oxidation mechanism. Thus, we tested the hypothesis that increase in VB with aging activates mTORC1 and stimulates lung aging.

 Plasma collected from 179 healthy humans (age; 21 to 75) without known disease (CHDWB, Center for Health Discover and Well Being), and lungs from mice (6 mo and 24 mo, n = 24 each) were analyzed for VB by high resolution metabolomics (HRM). Lung fibroblasts (LF) treated with VB were analyzed for activation of mechanistic target of rapamycin (mTOR) pathway by Western blot analysis.

 VB concentration in human plasma was significantly increased with age (P = 0.0004, r = 0.26). Consistently, lung VB level in old mice were significantly higher than young mice (P = 0.004). LF treated with VB stimulated phosphorylation of mTOR and ribosomal protein S6 as markers for mTORC1 activation, and rapamycin mTORC1 inhibitor substantially decreased VB-stimulated phosphorylation of S6 and mTOR.

 The results show significant association of VB with aging in human and mouse lung studies, and VB-stimulated mTORC1. The finding suggests that microbiome metabolite VB could impact aging and indicates that studies are needed to understand potential dysfunctions related to age and age-associated diseases such as pulmonary fibrosis.

 NIH R01 ES023485 and S10 OD018006.


An investigation of the overpressure condition in Afam field was carried out using a suite of borehole logs and 3D seismic data obtained from Shell petroleum Development Company of Nigeria (SPDC) with a view to detecting and predicting abnormal pressure zones in the area. The methodology employed knowledge of well lithology and more detailed information extracted from inverted seismic traces. The interval velocity data of some shot lines within the study field and its immediate environment were computed to ascertain the pressure variations and the geological model of the less known areas from seismic data. Using well data near the seismic trace for calibration, precise stratigraphic interpretation of the constructed interval velocity section was carried out. The overpressure zones were identified and probable hydrocarbon distribution pattern within the field was established and correlated with the geology of the study area.. The results obtained revealed five tops of overpressure (TOV) namely TOV 1, TOV 2, TOV 3, TOV 4, and TOV 5 at 1608.8m, 1884.1m, 2387.3m, 2708.9m and 3001.4m respectively derived from seismic and lithologic logs including their lateral variations. .The plot of the Normal Compaction Trend versus velocities obtained from sonic logs also confirmed the identified overpressure zones. The five horizons representing the identified overpressure zones were picked on the 3D seismic sections at 1.42 s, 1.75 s, 2.01 s, 2.11 s and 2.30 s respectively, with thickness varying from 4.08 m to 50.58 m. In-addition, the water saturation (Sw) and porosity  values calculated showed that the overpressure zones were generally characterized by high water saturation (52 % to 80.36%) and low porosity (16.55 % to 30.80 %). Furthermore, four hydrocarbon-bearing zones, which were overlain by thin over pressured shale beds, were delineated at 2657 m, 2804 m, 2916.9 m and 3048 m respectively. This case study shows how knowledge of well site lithology and detailed information from seismic data could enable prediction match well conditions with high fidelity thereby reducing drilling cost, prospect risk and improving safety.. Keywords : overpressure, compaction, interval velocity, Shale, amplitude inversion


There seem to be no effective alternatives to surgery or angioplasty for patients with peripheral vascular disease, but this report and some previous


In the designing of Fuzhou City's spatial distribution of tourism,the paper chooses the point-axis development pattern.And on the base of this pattern,the paper partitions the city into three tourism cooperation zones according to the principles of resource complementarity They are coast-mountains interaction zone,cooperation zone of the ring around Luoyuan Bay and continent-islands linkage zone.In the practical application of the spatial distribution of tourism,examples are given to show the designong of the three tourist lines from the urban to mountains,to coasts and to islands.


Very recently, we have proposed an approximate scheme for calculating the PD on the basis of the extended constrained-search theory [10–14]. By introducing a noninteracting reference system [10,11], the resultant PD corresponds to the best solution within the set of PDs that are constructed from a single Slater determinant (SSD). This PD functional theory has two kinds of merit. The first is that the reproduced PD is necessarily N-representable. This is a strong merit because the necessary and sufficient conditions for the N-representable PD are not yet known exactly. The second merit is the tractable form of the kinetic energy functional. The kinetic energy functional cannot exactly be written by using the PD alone. Some approximation is required. In this theory, we have successfully given an approximate form of the kinetic energy functional with the aid of the coordinate scaling of electrons [10].


【High strength sheet steels for automobile are seriously compromised by hydrogen embrittlement. This issue has been continuously studied, but the field of interest, which lies between microstructural characteristics and hydrogen behavior with hydrogen charging, has not yet been thoroughly investigated. This study was done to investigate the behavior of hydrogen according to the hydrogen volume fraction on 590MPa grade DP steels, which are developed under hydrogen charging conditions as high strength sheet steels for automobiles. The penetration depths and the mechanical properties, according to charging conditions, were investigated through the distribution of micro-hardness and the microstructural observation of the subsurface zone. It was found that the amount of hydrogen trapping in 590MPa DP steels was related to the austenite volume fraction. It was confirmed that the distribution of micro-hardnesses according to the depth of the subsurface zone under the free surface showed the relationship of the depth of the hydrogen saturation between the charging conditions.】


In CMOS logic circuits, the reduction in the threshold voltage due to voltage scaling leads to increase in the subthreshold leakage current and hence static power dissipation. Although power consumption is important for modern VLSI design, operation speed and occupied area are still the main requirements of the VLSI design. Multi threshold voltage CMOS (MTCMOS) technology is a good solution which provides a high performance and low-power design without any area overhead. MTCMOS technology provides the transistors that have low, normal and high threshold voltage. The low-threshold voltage transistors are used to reduce the propagation delay time in the critical path, the high-threshold voltage transistors are used to reduce the power consumption in the shortest path. This paper describes a low-power and high speed design for full adder, 4-bit ripple carry adder and 4×4 multiplier circuits with MTCMOS technology using 45nm technology. Keywords— Multi-threshold voltage CMOS (MTCMOS), static power consumption, propagation delay.


SUMMARY: Infectivity titrations and electron microscopic spray counts were performed on purified preparations of adenovirus type 5. The number of virus particles/50% infective units varied from 10 to 100 with different preparations.


Let 1$ SRC=http://ej.iop.org/images/0025-5734/27/2/A03/tex_sm_2508_img2.gif/> be a real transcendental number. In this paper a number is constructed such that the sequence is completely uniformly distributed. For real 1$ SRC=http://ej.iop.org/images/0025-5734/27/2/A03/tex_sm_2508_img5.gif/> () numbers are constructed such that the remainder of the uniform distribution of the sequence (), , is equal to .Bibliography: 6 titles.


Cerium-based conversion coatings were deposited on as-cast aluminum alloy 380 substrates by a spontaneous immersion process. In this study, the effects of rinsing temperature prior to immersion in the coating deposition solution were studied with respect to the surface morphology, electrochemical response, and corrosion resistance of the coatings. Panels rinsed at 25∘C prior to coating had large cracks and holes in the coating. In contrast, panels rinsed at 100∘C prior to coating had a uniform coating morphology with fewer, smaller cracks. Electrochemical testing revealed that coatings deposited on substrates rinsed at 100∘C had higher impedance (~80 kΩ·cm2) and lower corrosion current (~0.34 𝜇A/cm2) compared to coatings deposited on substrates rinsed at 25∘C, which had 10 kΩ·cm2 impedance and 2.7 𝜇A/cm2 corrosion current. Finally, ASTM B117 salt spray testing showed that rinsing at 100∘C prior to coating resulted in cerium-based conversion coatings that could resist the formation of salt tails for at least 8 days.


An optical high pressure apparatus for stimulated Brillouin scattering is described. The method employs a hydrostatic piston cylinder cell with a sapphire window of 6 mm diameter aperture. From measurements of the frequency shift between room temperature and 150 degrees C, sound velocity data can be obtained. Results for atactic polystyrene up to 300 MPa are presented as an example.


Contents: Preface Introduction: Kierkegaard and Nietzsche vis-A -vis the analytic tradition. Part 1 Kierkegaard contra Nietzsche: Foreword Kierkegaard's challenge From aestheticism to ethics From ethics to religion. Part 2 Truth and Communication: Foreword Truth Communication. Conclusion: equality and power Recommended reading Bibliography Index.


Transformations from the rotating reference frame of the slip-ring primitive to the quasi-stationary reference frame of the commutator primitive are developed with no limitations on winding MMF harmonics and air gap permeance harmonics other than those set by machine symmetry. The transformations are shown to reduce to Kron's classical transformation when harnonics of both MMF and permeance higher than the second are neglected.


The Gravity Probe B (GP‐B) satellite photometric system and instrumentation are introduced. Observational results are presented for calibration stars demonstrating a single‐orbit relative photometric precision capability of 500 μmag for bright stars. Broadband photometric observations of the bright star ζ Pegasi are then presented that display brightness variability of 488.2 ± 6.6 μmag (parts per million), with a period of 22.952 ± 0.804 hr (f ≈ 1.04566 cycles day−1). Over the short observational period, the variation is monosinusoidal, thus recommending the star for membership in the class of small‐amplitude, slowly pulsating B (SPB) star variables oscillating in a nonradial g‐mode.


In this paper we describe an experiment designed to measure solar and celestial X-rays in the energy range between 15 to 250 keV. The experiment was flown on the fifth Orbiting Solar Observatory which was launched on Jan. 22, 1969. Up to the time of this writing the instrument continues to operate satisfactorily.


n the conditions of modern fish farming, the issues of product quality management, along with the achievement of high fish productivity, occupy one of the key places in scientific research. This increases the role of the system of scientific support of the technological process of production, in which the feeding of fish is important. Properly balanced feeding, with optimal growing conditions, is a key factor influencing the intensity of fish growth and economic performance of the industry. In a number of works it has been proved that by optimizing the energy supply of rainbow trout, it is possible to ensure a high level of productivity and improve the quality of their products. Thus, the study of the impact of different energy supply of rainbow trout this year in the modern industrial conditions of cold-water fish farms in Ukraine is necessary and relevant. Material and methods of research. Experimental studies on this yearling rainbow trout Oncorhynchus mykiss (Walbaum, 1792) were conducted in the farm "Shipot" Perechyn district of Zakarpattia region. The purpose of the scientific and economic experiment was to establish the influence of different levels of energy supply of this year's trout on their productivity. During the equalization period, the experimental fish consumed feed of the control group. In the main period, the level of metabolic energy in the feed of trout of the experimental groups was regulated by changing the individual components of the feed (using combined mathematical methods to optimize the calculation using the program AgroSoft WinOpti). Feeding rainbow trout this year was carried out 6 times a day, during the day at regular intervals. The required amount of feed was calculated according to the indicators of individual weight of young and the temperature of the environment at the time of feeding. The planting density of the experimental fish at the beginning of the experiment was 200 sp/m2. Growing of young was carried out in ponds with a water level of 1 m. Control catches of experimental trout were performed once every 5 days. Weighing on electronic scales was subjected to 100 individuals from each group. The research results were processed by the method of variation statistics using MS Excel and STATISTICA 7.0 software using built-in statistical functions. Research results and their discussion. It was found that at the end of the experiment (45 days) the highest mass was reached by this year of the 4 and 5 groups, which outperformed the analogues of the control group by 5.5 and 10.4%, respectively (p<0.05). At the same time, this year of the 2 and 3 experimental groups were inferior to the mentioned indicator to control peers by 1.19 and 0.52 g, respectively, or by 10.7 (p<0.05) and 4.7%. The difference between the weight of fish of the 2 and 5 groups, which consumed feed with a metabolic energy content of 15 and 19 MJ, respectively, in this period was 23.5% in favor of the latter. Data from analysis of variance show that different levels of energy nutrition of this year of trout significantly (p<0.001) affected the weight of the experimental fish. The share of influence of this factor is 79.7%, which is almost 4 times higher than the influence of other factors. Calculations of the average daily weight gain of this year's trout showed that during the growing period the nature of their changes depended on the level of metabolic energy in the feed and the corresponding dynamics of fish growth. It should be noted that in general for the main period of the experiment large average daily weight gain was characterized by this year 4- and 5 experimental groups receiving feed with metabolic energy content at the level of 18 and 19 MJ, which by this indicator exceeded the control, respectively 7.0 and 13.2%. Yearlings of trout of the 2nd and 3rd experimental groups, which consumed compound feed with a content of metabolic energy at the level of 15 and 16 MJ, in the main period of the experiment were inferior to the control indicator by 12.7 and 6.1%, respectively. The difference between peers of the 2 and 5 groups in the average daily weight gain for the main period of the experiment was 29.6%. Тhe analysis of feed costs shows that the use of compound feed with a metabolic energy content of 19 MJ (group 5) for the main period of the experiment for feeding this year trout helped to reduce their costs per unit of weight gain compared to fish that consumed feeds with lower energy levels. Thus, the cost of feed per 1 kg of weight gain in this year of the 5 group was 0.794 kg, which is 0.31; 0.86; 0.57 and 0.19 kg less than in the 1, 2, 3 and 4 groups, respectively. It should be noted that the safety of the experimental fish throughout the experiment was quite high and ranged from 74.3 to 76.7%. It can be stated that the increase in nutrient content of feed from 15 (2 group) to 19 MJ (5 group) leads to an increase in ichthyomas during the main period of the experiment by 6.9-37.5%. As a result of different feed costs per unit weight gain of fish, this indicator and its cost per total increase in ichthyomas differed markedly by experimental groups. All this, in the end, affected the unit cost of growth of ichthyomas of this year's trout, was the lowest in fish that consumed food with a nutritional value of 17 MJ (1 group). In particular, according to the mentioned indicator, they outperformed analogues of all other groups, respectively (according to the scheme of the experiment) by 17.0; 19.4; 2.9 and 2.1%. Thus, from an economic point of view, when growing trout this year, they should be fed compound feeds with a metabolic energy level of 17 MJ.


Snake-like robots are commonly used in Minimally Invasive Surgery as they are able to reach areas deep inside the human body. These robots have instruments that are deployed out of the robot's head and controlled via tendons, which connect the instrument to motors at the proximal end. In most currently available systems the instruments are lacking a rolling motion of the end-effector.In this paper, we present a new instrument prototype for a snake-like robot that can perform a stable in-place rolling motion. The prototype has a diameter of 4mm, uses 13 tendons and has 6 degrees of freedom. The robot can bend and roll to high angles, and strongly improves the dexterity compared to an instrument without rolling capabilities. In the evaluation we show that the rolling-tip gripper can rotate about 165° and is capable of applying forces up to 6.5N.


Objective
To investigate the current situation of nosocomial cardiopulmonary resuscitation (CPR)skills of community nurses in the regional health alliance and its influencing factors.

Methods
Nosocomial CPR first-aid skills of 104 in-service nurses from 6 community hospitals in the regional health alliance using a convenience sampling method were investigated.

Results
The score of the CPR skill examination of community nurses in the health alliance was (75.6±11.3), which was lower than the score of nurses in the leading hospital. The subjects with the three lowest accuracy were: the technique and the items of the bag safety inspection of the bag valve mask (8.7%, 10.6%), the CE method to hold the mask (15.4%). The multiple linear regression test showed that community nurses′ education, working age, weather they had attended related training were influencing factors of the nosocomial CPR skill score of community nurses in the health alliance.

Conclusions
Nosocomial CPR skills of community nurses in the regional health alliance need improving. The leading hospital in the health alliance should fully integrate resources and strengthen the first-aid skill training of community nurses in the regional health alliance in order to ensure medical safety in the community.

Key words:
Community nursing; Health alliance; Nursing skill; Current situation investigation


Stresses within unsteady simple shear flows of suspensions of non-Brownian spheres constrained to move in the velocity-gradient plane are calculated using Stokesian dynamics simulations. The unsteady flows considered include shear reversal and oscillatory flows of varying strain amplitude. The evolution of the stresses in time are reported along with the corresponding microstructural development for all flow conditions. For shear reversal, the shear stress rapidly decreases to a minimum before gradually returning to the steady state value reached in the previous direction, whereas the normal stress briefly changes sign upon reversal of shear before returning to the steady state value. For oscillatory shear flow, the shear stress increases with total strain before attaining a steady state that depends upon the applied strain amplitude, indicating irreversible behavior even at small strain amplitudes. The shear stresses show a nonmonotonic dependence on the applied strain amplitude that agrees with experime...


Tax revenue has been the most substantial source of government incomerecently. In 2009, about 73 percent of government revenue came from taxes. Thisforces taxation office to perform some efforts to maximize tax revenue. One of them isto employ self assessment system. In this system, taxpayer's awareness andcompliance is important. Factors influencing taxpayer's compliance includetaxpayer's perception of tax penalty and taxpayer's awareness.This research aims to examine the effect of perception of tax penalty and taxawareness on taxpayer's compliance in taxation office Pratama Denpasar Timur.Sample is drawn using simple random sampling method, and consists of 100effective taxpayers as respondents. Data then are analyzed using multiple linearregression technique. The result shows that perception of tax penalty and taxpayer'sawareness simultaneously affects taxpayer's compliance with adjusted R-square of0.498. Partially, the two variables provide significant positive effect on taxpayer'scompliance.


Introduction:
 The cardiovascular effects of COVID-19 in elite athletes is still a matter of intense scientific debate.

 Hypothesis:
 We sought to perform a comprehensive echocardiographic characterization of post-COVID athletes by comparing them to a non-COVID athlete cohort.

 Methods:
 107 elite athletes with COVID-19 were prospectively enrolled (P-CA; 23±6 years, 23% female) 107 healthy athletes were selected as a control group using propensity score matching (N-CA). All athletes underwent 2D and 3D echocardiography. Left (LV) and right ventricular (RV) end-diastolic volumes (EDVi) and ejection fractions (EF) were quantified. To characterize LV longitudinal deformation, 2D global longitudinal strain (GLS) and the ratio of free wall versus septal longitudinal strain (FWLS/SLS) were also measured. To describe septal flattening (SF - frequently seen in P-CA), LV eccentricity index (EI) was calculated.

 Results:
 P-CA and N-CA athletes had comparable LV and RVEDVi (P-CA vs N-CA; 77±12 vs. 78±13mL/m2; 79±16 vs 80±14mL/m2). P-CA had significantly higher LVEF (58±4 vs 56±4%, p<0.001), while LVGLS values did not differ between P-CA and N-CA (-19.0±1.9 vs -18.8±2.2%). EI was significantly higher in P-CA (1.13±0.16 vs 1.01±0.05, p<0.001), which was attributable to a distinct subgroup of P-CA with a prominent SF (n=35, 33%), further provoked by inspiration. In this subgroup, the EI was markedly higher compared to the rest of the P-CA (1.29±0.15 vs 1.04±0.08, p<0.001), LVEDVi was also significantly higher (80±14 vs 75±11 mL/m2, p<0.001), while RVEDVi did not differ (82±16 vs 78±15mL/m2). Moreover, the FWLS/SLS ratio was significantly lower in the SF subgroup (91.7±8.6 vs 97.3±8.2, p<0.01). P-CA with SF experienced symptoms less frequently (1.4±1.3 vs. 2.1±1.5 symptom during the infection, p=0.01).

 Conclusions:
 COVID-19 infection might be frequently associated with a constriction-like physiology in elite athletes.


Still following Colonna, the second chapter moves to the Mexican Treasure (1651), a vast commentary on Mexican fauna and flora and the academy's main collective project. Colonna's approach to the business of identifying plants is skillfully placed within the contemporary transformation of botanical research but also in the longer history of the discipline. Physicians and naturalists cooperating with Colonna are singled out, but further insight into their social and intellectual identity would have been helpful. Well connected, Colonna also gathered and passed on information about the civet, an animal whose production of a scented liquid from an area close to the genitals obsessed Renaissance naturalists. Reconstructing this obsession—but not its cultural significance—the authors also engage with De hyaena odorifera (1638), the report of a dissection of the civet by Pietro Castelli, whose career as a physician and botanist in Rome and Sicily, including his attempted reform of the medical curriculum, provides one of the book's unifying themes. Anatomical investigations from the 1630s to the 1650s are the main focus of the third chapter, where historians of medicine will find valuable information about the network of anatomists connecting Naples to Germany and Denmark via Padua. A key player was the well-known Neapolitan surgeon Marco Aurelio Severino, whom foreign medical students and fellow anatomists in Padua would come to meet as part of their Italian tour. The chapter gives tantalizing glimpses of their conflicts but is particularly effective at conveying Castelli's growing sense of isolation and Severino's struggle to promote reforms locally while desperately seeking help and connections abroad. To those unfamiliar with the history of southern Italy, much remains implicit in this book, and the prose is sometimes unnecessarily convoluted, but persistent readers will be rewarded with useful information and food for thought about the relations between centers and their so-called periphery in the seventeenth century.


The orbital contribution to the magnetic properties of Fe in systems of decreasing dimensionality bulk, surfaces, wire, and free clusters is investigated using a tight-binding Hamiltonian in an s, p, and d atomic orbital basis set including spin-orbit coupling and intra-atomic electronic interactions in the full Hartree-Fock HF scheme, i.e., involving all the matrix elements of the Coulomb interaction with their exact orbital dependence. Spin and orbital magnetic moments and the magnetocrystalline anisotropy energy MAE are calculated for several orientations of the magnetization. The results are systematically compared with those of simplified Hamiltonians which give results close to those obtained from the local spin density approximation. The full HF decoupling leads to much larger orbital moments and MAE which can reach values as large as 1B and several tens of meV, respectively, in the monatomic wire at the equilibrium distance. The reliability of the results obtained by adding the so-called orbital polarization ansatz OPA to the simplified Hamiltonians is also discussed. It is found that when the spin magnetization is saturated, the OPA results for the orbital moment are in qualitative agreement with those of the full HF model. However, there are large discrepancies for the MAE, especially in clusters. Thus, the full HF scheme must be used to investigate the orbital magnetism and MAE of low dimensional systems.


A self-editing algorithm is one that edits its program. The present paper studies evolution of self-editing algorithms that undergo some form of natural or artificial selection.


Changes of electrostatic potential around the DNA molecule resulting from chemical modifications of nucleotides may play a role in enzymatic recognition of damaged sites. Effects of chemical modifications of nucleotides on the structure of DNA have been characterized through electronic structure computations. Quantum mechanical structural optimizations of fragments of five pairs of nucleotides with thymine or thymine glycol were performed at the density functional level of theory with a B3LYP exchange-correlation functional and 6-31G(d,p) basis sets. The electrostatic potential (EP) around DNA fragments was projected on a cylindrical surface around the double helix. The 2D maps of EP of intact and damaged DNA fragments were compared using image analysis methods to identify and measure modifications of the EP that result from the occurrence of thymine glycol. It was found that distortions of phosphate groups and displacements of the accompanying countercations by up to approximately 0.5 angstroms along the axis of DNA are clearly reflected in the EP maps. Modifications of the EP in the major groove of DNA near the damaged site are also reported.


AMedicinal plants always play an important role in pharmaceutical applications. Swertia chirayita is one of the chief plants of the Gentianeace family. It is a potent drug used in Ayurveda, Siddha, and Homoeopathy in many formulations and is efficient in the healing of a range of diseases. The foremost emphasis of this assessment is in the direction of evaluating the versatile, multi-potential medicinal use of Swertia chirayita and updating information about pharmacognostical, phytochemical, and pharmacological studies. Swertia chirayitais has extensive types of characteristics, such as antibacterial activity, antifungal activity, antioxidant activity, etc. The current scenario and condition of this plant show that the prevailing number of these species is ebbing at a very great proportion. So, there must be different efficient conservation and sustentation strategies that can be put into effect for the preservation of this plant in its natural ecosystem. If felicitous methods are not augmented and employed, the extinction of these species cannot be ruled out anytime soon in the future. So, at this critical stage, there must be some urgent and active conservation strategies to be implemented at the earliest possible date. Keywords: Swertia chirayita, Gentianaceae, Chemical composition, Amarogentine, Pharmacological.


Adolescent mental health cannot be ignored, and psychological pressure is one of the prominent problems of current teenagers. Micro-blog, as the most important information exchange and broadcast tool in the current society, is becoming an important channel for teenagers' information acquisition, inter-interaction, self-expression, emotion release due to its unique equality, freedom, fragmentation, individuality characteristics. This poster envisions a micro-blog platform, aiming to (1) sense psychological pressures through teenagers' tweets, and (2) assist teenagers to release their stress through micro-blog. A method for timely detecting psychological pressures from teenagers' tweets is particularly described. Our preliminary experimental results on real data demonstrate the validity of the approach. We also discuss ways to assist teenagers to release their pressures through micro-blog at the end of the poster.


Intelligent reflecting surface (IRS) is envisioned to change the paradigm of wireless communications from "adapting to wireless channels" to "changing wireless channels". However, current IRS configuration schemes, consisting of sub-channel estimation and passive beamforming in sequence, conform to the conventional model-based design philosophies and are difficult to be realized practically in the complex radio environment. To create the smart radio environment, we propose a model-free design of IRS control that is independent of the sub-channel channel state information (CSI) and requires the minimum interaction between IRS and the wireless communication system. We firstly model the control of IRS as a Markov decision process (MDP) and apply deep reinforcement learning (DRL) to perform real-time coarse phase control of IRS. Then, we apply extremum seeking control (ESC) as the fine phase control of IRS. Finally, by updating the frame structure, we integrate DRL and ESC in the model-free control of IRS to improve its adaptivity to different channel dynamics. Numerical results show the superiority of our proposed joint DRL and ESC scheme and verify its effectiveness in model-free IRS control without sub-channel CSI.


With the experimental evidences of $\overline B{}^0\to p\bar p$ and $B^−\to\Lambda\bar p$ decays, it is now possible to extract both tree and penguin amplitudes of the charmless two-body baryonic $B$ decays for the first time. The extracted penguin-tree ratio agrees with the expectation. Using the topological amplitude approach with the experimental results on $\overline B{}^0\to p\bar p$ and $B^−\to\Lambda\bar p$ decay rates as input, predictions on all other $\overline B_q\to{\cal B}\overline{\cal B}$, ${\cal B}\overline{\cal D}$, ${\cal D}\overline{\cal B}$ and ${\cal D}\overline{\cal D}$ decay rates, where ${\cal B}$ and ${\cal D}$ are the low lying octet and decuplet baryons, respectively, are given. It is non-trivial that the results do not violate any existing experimental upper limit. From the analysis it is understandable that why $\overline B{}^0\to p\bar p$ and $B^−\to\Lambda\bar p$ modes are the first two modes with experimental evidences. Relations on rates are verified using the numerical results. We note that the predicted $B^−\to p\overline{\Delta^{++}}$ rate is close to the experimental bound, which has not been updated in the last ten years. Direct CP asymmetries of all $\overline B_q\to{\cal B}\overline{\cal B}$, ${\cal B}\overline{\cal D}$, ${\cal D}\overline{\cal B}$ and ${\cal D}\overline{\cal D}$ modes are explored. Relations on CP asymmetries are examined using the numerical results. The direct CP asymmetry of $\overline B{}^0\to p\bar p$ decay can be as large as $\pm50\%$.


At present, toll gates in the highways are considered to be the bottleneck in the traffic flow. Managing the traffic and payment by the vehicle and close monitoring the vehicles are difficult. Hence a highly sophisticated system is designed that monitors each vehicle entering and leaving the toll gates and a bill is issued to the driver which he can pay later in a monthly or weekly pattern he chooses by either paying directly or by linking it to his/her bank account. Also the system monitors illegal vehicle that tries to pass the toll gates. The system triggers the alarm and activates the spikes that are incorporated at the exit of the toll gates and informs the police official. A RFID reader is incorporated in the toll gates and each cars are given RFID tags. The information about the car and the criminal records, if any, are stored in the data base. The system updates the database each time the car passes the toll gate. A pressure sensor is used to find the number of persons inside the car apart from a camera to find if there are any hidden person inside. The cars that emits harmful gas carbon mono oxide due to bad emission or any other harmful gases like a driver smoking or any drugs can also be detected using the gas sensors deployed.


IN the present volume, the first instalment of a systematic account of the recent Cephalopoda, Mr. G. C. Robson has attacked the most difficult part of the work—the classification of the subfamily Octopodinse, the largest division of the order Octopoda. The difficulty of classification is enhanced by post-mortem changes which modify or efface the sculpture of the skin and distort the shape of the body and head, by the amount of material available for the study of a single species being generally limited, and hence the amount of variation of the species unknown, and by the defective descriptions of earlier workers, which are often based on more or less valueless characters. The author directs attention to the need for intensive studies on the variation of a single species carried out on living examples, and gives the results of an examination of a number of characters in twenty-one specimens of Octopus vulgaris.A Monograph of the Recent Cephalopoda: based on the Collections in the British Museum (Natural History).Part 1: Octopodinæ. By G. C. Robson. Pp. xi + 236 + 7 plates. (London: British Museum (Natural History), 1929.)


Data Swapping is a popular value-invariant data perturbation technique. The quality of a data swapping method is measured by how well it preserves data privacy and data utility. As swapping data globally is computationally impractical, to guarantee its performance in these metrics appropriate, localization schemes are often conducted in advance. Equi-depth partitioning is preferred by most of the existing data perturbation techniques as it provides uniform privacy protection for each data tuple. However, this method performs ineffectively for two types of applications: one is to maintain statistics based on equi-width partitioning, such as the multivariate histogram with equal bin width, and the other is to preserve parametric statistics, such as covariance, in the context of sparse data with non-uniform distribution. As a natural solution for the above application, this paper explores the possibility of using data swapping with equi-width partitioning for private data publication, which has been little used in data perturbation due to the difficulty of preserving data privacy. With extensive theoretical analysis and experimental results, we show that, Equi-Width Swapping (EWS)can achieve a similar performance in privacy preservation to that of Equi-Depth Swapping (EDS) if the number of partitions is sufficiently large (e. g. &get;=sqrt(N), where N is the size of dataset). Our experimental results in both synthetic and real-world data validate our theoretical analysis.


Size-matched groups of three-spined stickleback (Gasterosteus aculeatus) fry were established using fish from two sites, one with abundant piscivorous predators (the high-risk site) and the other with very few heterospecific predators (the low-risk site). Over a period of two months, social interactions within groups were monitored regularly and mean lengths and coefficients of variance in length were tracked. Agonistic behaviour was observed in 45 % of observation periods, but was more common in the groups of fry from the low-risk site, where it was more likely to take the form of direct attack rather than displacement without contact. In both categories of fish, the great majority of agonistic acts were directed to fish of a similar size or smaller


The study of the concentrations of Cr, Zn, Cd, Pb, Ni, and Cu in soils under different land uses in rural, semi-urban, and urban zones in the Niger Delta was carried out with a view to providing information on the effects of the different land uses on the concentrations of trace elements in soils. Our results indicate significant variability in concentrations of these metals in soils under different land uses in rural, semi-urban, and urban zones. The maximum concentrations of metals in the examined soil samples were 707.5 mg.kg−1, 161.0 mg.kg−1, 2.6 mg.kg−1, 59.6 mg.kg−1, 1061.3 mg.kg−1, and 189.2 mg.kg−1 for Cr, Zn, Cd, Pb, Ni, and Cu, respectively. In the rural zone, the cassava processing mill is a potent source of Ni, Cr, Cu, and Zn while agricultural activities are a source of Cd, and automobile emissions and the use of lead oxide batteries constitute the major sources of Pb. In the urban zone, soils around the wood processing mill showed elevated concentrations of Cu, Cr, Zn, and Ni, while soils around automobile mechanic works and motor parks showed elevated levels of Pb. Elevated Cd concentrations were observed in soils under the following land uses: urban motor park, playground, welding and fabrication sheds, and metallic scrap dump. The contamination/pollution index of metals in the soil follows the order: Ni > Cd > Cr > Zn > Cu > Pb. The multiple pollution index of metals at different sites were greater than 1, indicating that these soils fit into "slight pollution" to "excessive pollution" ranges with significant contributions from Cr, Zn, Cd, Ni, and Cu.


Abstract : This study determines if the 105mm howitzer should be the future direct support weapon system for light forces from now until the year 2010 and beyond. As the Army prepares to enter the twenty-first century, there is a current capability void toward an indirect fire weapon system that supports a mission profile for light forces able to conduct forced entry operations and have airborne and air assault capabilities. The analysis for this study compares the 105-mm howitzer against a l2Omm mortar and a towed 155-mm howitzer to determine which weapon system is capable to supporting light forces. Lethality, mobility, and survivability are the overall measurements of criteria comparing these three weapon systems against each other. Evaluating each weapon system's capabilities in relation to the criteria of measurements reveal indirect firing platform. Final analysis determines that the 105-mm howitzer should be the future direct support weapon for light forces by consistently ranking within the competing parameters of evaluation. Analysis depicts how the 105-mm howitzer does not rank in the low end for any of the measurements of criteria as compared to the 120-mm mortar and 155-mm howitzer. Comparison data reveals that muzzle loaded mortars have inherent internal and weapon associated characteristics that limit the accuracy of the weapon systems to effectively fire on a target.


Earthquake with the characteristics of sudden, unpredictability, instantaneous and induced secondary disasters has always been one of the most serious natural disasters, and population is an important disaster body. The intensity and frequency of earthquakes in Guizhou province are generally at the national middle level. To better meet the needs of disaster prevention work, the Guizhou population carrier spatial information and historical earthquake disaster attribute information, analyze the spatial pattern characteristics, grasp the risk factor information, not only can do the relevant information and data supplement, and the ongoing comprehensive disaster risk census work has certain data supporting role.


5542Background: Immunization against self-antigens can induce regulatory responses that inhibit the development of desirable Type I antitumor immune responses. Removing epitopes that bias toward a ...


Abstract A resonant photoacoustic cell, capable of contamination free operation at temperatures above that of the ambient, was constructed and used to determine absolute absorption coefficients of C6:0 (hexanoic) and C8:0 (octanoic) fatty acid vapours at CO2 laser wavelengths. At atmospheric pressure, the maximum absorption coefficients at the 9R(32) line of the CO2 laser (1085.77cm−1) are 8.0 atm−1 cm−1 (C6:0 at 332K) and 8.9 atm−1 cm−1 (C8:0 at 342 K). Email address: Thomas-Finkat-online.de.


Differences in the degree of pain stimulation (a fractured femur compared with a splinter in the toe) and pain sensitivity (Figure 1), weight and age differences, prior opioid use and tolerance, and the differences in bioavailability of various opioid formulations have been cited as causes for the wide variability in analgesia seen with opioids. However, even measuring blood levels of opioids does not predict analgesia. Just as there are differences in hair and eye color, there are differences in response to pain and to analgesic medications. We are beginning to recognize that, as is seen in much of medicine in the 21st century, genetics may explain the variability of responses and predict more effective (or less dangerous) medication choices. By identifying the genetic risks and the most effective analgesic for an individual patient, the clinician (at least theoretically) could improve the efficacy of the pain medication and decrease the risk for iatrogenically induced overdose, addiction, and death.


Modeling spillover effects from observational data is an important problem in economics, business, and other fields of research. It helps us infer the causality between two seemingly unrelated set of events. For example, if consumer spending in the United States declines, it has spillover effects on economies that depend on the U.S. as their largest export market. In this paper, we aim to infer the causation that results in spillover effects between pairs of entities (or units); we call this effect as paired spillover. To achieve this, we leverage the recent developments in variational inference and deep learning techniques to propose a generative model called Linked Causal Variational Autoencoder (LCVA). Similar to variational autoencoders (VAE), LCVA incorporates an encoder neural network to learn the latent attributes and a decoder network to reconstruct the inputs. However, unlike VAE, LCVA treats the latent attributes as confounders that are assumed to affect both the treatment and the outcome of units. Specifically, given a pair of units u and $\baru $, their individual treatment and outcomes, the encoder network of LCVA samples the confounders by conditioning on the observed covariates of u, the treatments of both u and $\baru $ and the outcome of u. Once inferred, the latent attributes (or confounders) of u captures the spillover effect of $\baru $ on u. Using a network of users from job training dataset (LaLonde (1986)) and co-purchase dataset from Amazon e-commerce domain, we show that LCVA is significantly more robust than existing methods in capturing spillover effects.


One is without significantly replacing the other, without inhibiting the initial effectiveness of any active drug, combined pharmaceutical formulations comprising two different active drugs of the same ionic charge conjugated with one of the resin particles. Further, a plurality of active drug - a method of manufacturing a resin conjugate, and a plurality of active drug - a pharmaceutically released in vivo method of the combination of the active drug from the resin conjugate.


Seaking for new varieties with high agronomical potential is a major concern for breeders. Practically, the introduction of a new variety at the farmer level requires germplasm evaluation in order to get the necessary informations about its identification. In this context, the aim of our study is to characterize using biochemical (protein and sugar contents) and physiological (behavior against salinity and drought) bases, describe and finally identify interesting barley lines, in comparison with two control varieties (Manel and Rihane). The analysis of the different studied parameters shows a significant diversity among lines, although they could be somehow very close within some characters. However, when considering the whole descriptive parameters, it appears that L6 line is highly performant at several levels including its soluble sugars (4 μg/mg MS), starch (143 μg/mg de MS), nitrogen and protein contents, but also its behavior with regard to salt and water stresses.


PURPOSE: Provided is a luminous and fluorescent film which protects luminous paint from external force so that it helps to keep excellent luminous effect for a long time. CONSTITUTION: The luminous and fluorescent film is characterized by comprising the parts of: a raw film(101); an adhesive layer(102) for luminous and fluorescent laminating which is formed by coating one side of the raw film by an adhesive for luminous and fluorescent laminating wherein adhesive and luminous paint or adhesive, luminous paint and fluorescent dye are mixed; and a raw film(103) for laminating which is placed on one side of the raw film coated by the adhesive for luminous and fluorescent laminating to protect the adhesive for luminous and fluorescent laminating from external force.


Article is devoted to the analysis of current trends of change of the domestic educational paradigm, initiated by modern processes of education reform, idea influence of "the third mission of universities" on contents of educational programs, which performance is expressed in growth of number of patents, the signed contracts with the entities, a research of problems of the social sphere and the university involvement into welfare life of the region. In contrast to the harmful nature of the technogenic path of the idea of "entrepreneurial university», the author emphasizes importance of implementation of noosphere educational technologies of development of person creativity and social responsibility of future specialist. The aim of the study was to search for the philosophical and methodological foundations of the concept of noospheric education, which allows answering the challenge of the idea of the third mission of  the university in society and an analysis of the creativity degree of trainees in mastering professional competencies via e-learning with the study of the focus group of master students in the profile "Sociology of Management". The basic methods of research that allow students to demonstrate the creativity of educational objectives problems were the forms of immersion of the student into the situation of application of the acquired educational skills of the solution of the problem posed as close to reality as possible, developed on the basis of the system of electronic training «InfOUPro», introduced at Kemerovo State University. A deliberately formed teaching model of an independent choice of tools and techniques in the solution of the task, set by the lecturer in assessing its application for the period 2015–2017 demonstrated the growth of non-standard creative solutions among students, which allows us to assert that the application of noospheric methods of developing intuitive figural right hemispheric thinking in harmony with the skills of discursive-logical thinking allowed 73% of master students to show an individual style of solving educational problems, demonstrate creative skills of personal growth, to strengthen the leadership qualities of self-learning and the duration of retention of educational interest to students.  Open creative tasks, modeling future professional activity, are actively made and with great interest. The ability to initiate intuitive imagery right hemisphere thinking in harmony with the skills of discursive and logical thinking of master students in the development of research skills provides such noospheric educational technologies for the development of the learner's creativity as heuristic techniques for describing actions and states that help to approach the task (intuitive modeling of the subject of research, the reception of inversion, the reception of analogy, the method of free associations, the reception of focal objects), and creative methods, methods of generating ideas that allow to structure the problem, find a solution, structured technology to clearly outline the search zone of strong solutions of creative tasks. Distance form of e-learning based on the capabilities of the «InfOUPro» system showed effectiveness in applying the acquired educational skills and developing the professional competencies of the study group of students.


Computational methods can help in the design of new bioorganometallic compounds. However, the presence of multihapto or σ/π metal‐ligand bonding still precludes the direct application of either pure molecular mechanics (MM) or hybrid quantum mechanics‐MM methods to study the flexibility of biomolecules in complex with organometallics. Herein, we present a computational protocol aimed to the evaluation of the relative free energies of bioorganometallic compounds, which explores the conformational space by means of Molecular Dynamics simulations using the semiempirical PM6 method coupled with the COnductor‐like Screening MOdel solvation model followed by density functional theory (DFT) calculations including the DFT‐D3 dispersion energy correction on the most stable conformers. This protocol is applied to investigate the complexes formed between cysteine and the molybdocene entity Cp2Mo2+ (Cpη5C5H5), which has received considerable attention due to its potential antitumor activity and chemical reactivity. The calculated structures and free energies are in agreement with those of the experimentally detected molybdocene‐cysteine adducts and allow us to investigate the reaction mechanism for the formation of the most stable 1:1 and 1:2 adducts. © 2013 Wiley Periodicals, Inc.


Objective To research the treatment regularity of professor Li Guang-rong treating polycystic ovay syndrome(PCOS).Method Medical records of 54 PCOS patients treated by Professor Li for 638 consultations were input into database by structuralized medical history template.Systematically analyze the data with the System Software of OLD TCM Clinical Diagnosis and Treatment Information Collection.Results The treatment principle involving supplement kidney,invigorate blood,adjust liver,fortify spleen is comparatively frequently used;formulations including Decoction of self-prepared strengthening kidney,Decoction of Herba Lycopi,Ease Powder,Six-Ingredient Rehmannia Pill,Decoction of Atractylodes and Cyperus Expelling Phlegm are comparatively frequently used;19 herbal medicines are comparatively frequently used.The most frequently used medicine sort is supplement kidney medicine,followed by medicine of adjust liver,invigorate blood and fortify spleen.Conclusion Professor Li pays more attention to protecting yin-blood,supplementing kidney,adjusting liver and fortifing spleen in treating PCOS.The treatment is based on supplementing kidney and invigorating blood.The emotion factor should be emphasized.


This study develops an R&D-based growth model with basic and applied research to analyze the growth and welfare effects of two patent instruments (a) the patentability of basic R&D and (b) the division of profi�t between basic and applied researchers. We �find that for the purpose of stimulating basic R&D and economic growth simultaneously, increasing the share of profi�t assigned to basic researchers is more effective than raising the patentability of basic R&D, which has either a negative effect or an inverted-U effect on technological progress. Nonetheless, a benevolent patent authority requires both patent instruments to achieve the socially optimal allocation in the decentralized economy.


This study aims to analyze the construction of autonomy, life trajectories and the work, as well as the knowledge of self-employed workers and students of Adult and Adolescents Education (EJA) of Colegio de Aplicacao from UFRGS. The study also tries to find reasons that made these individuals return to school. The data collecting was done through questions and a semi structured interview. The obtained results were: a) the reasons for returning to school were knowledge, personal improvement and job upward; b) the autonomy is relative to work conditions and decision making; c) the trajectories were fragmented throughout child labor and school exclusion; d) the knowledge experience is constituted by the observation, daily relationships and by the autonomously search for information and knowledge.