GW.MATE provided general advice to Comisión Nacional del Agua (CNA) on the preparation and implementation of the World Bank-funded MASAS Project for the stabilization of selected Mexican aquifers through (among other measures) the consolidation of aquifer management organizations (the so-called COTAS). More specifically GW-MATE members have had periodic interaction during 2001-03 with Comision Estatal de Aguas de Guanajuato (CEAG) on their efforts to promote COTAS for a number of specific aquifer systems in Guanajuato state. This profile provides an impression for an international audience of the progress and way forward of the COTAS in Guanajuato. A very generous acknowledgement is due to the senior staff of the CEAG, the CNA-Subdirección General Técnica (SGT) and the COTAS of Irapuato and Silao-Romita for the constructive dialogue which made writing the profile possible, but the opinions expressed are those of the authors alone.


Tert-Butyl substituted salicylaldimine(1) was prepared and reacted with trans-[NiC1(Ph)(PPh3)] to give the salicylaldiminato nickel (Ⅱ) complex (4) {[0-(t-Bu)C6H2-ortho-C(H)=N-2, 6-C6H3(i-Pr)2]Ni (Ph3P)(Ph)}. The ligand and it's complex were characterized by MS, (superscript 1)H NMR and EA. The complex activated by Al(i-Bu)3 is efficient for ethylene polymerization at the molar ratio of Al(i-Bu)3 to catalyst (4) ranged in 2.5~40. At 8.4×10^5 Pa pressure, the polymerization activity of complex(4) reached 4.05×10^5 g PE/(mol Ni•h)and the Mη ranged from 0.34×10^4 to 3.68×10^4. In comparison with Ni(COD)2 as co-catalyst, it is obviously that Al(i-Bu)3/(4) is more favourable for ethylene polymerization.


In coastal cities, the effects of climate change will cause an increase in the intensity and frequency of extreme sea level (ESL). In this scenario, the application of the Coast-RiskBySea model is proposed to assess the economic impacts of ESL on the built environment in three Euro-Mediterranean coastal cities: Naples, Barcelona, and Marseille. The risk (land use-based) is assessed in the GIS environment as a function of the potential direct and tangible economic damages. The results highlight risk scenarios in all three cities with significant economic damages expected, requiring the implementation of climate mitigation and adaptation measures to reduce the current impacts and limit future ones. The simulations highlight the potential of both remote sensing data and GIS systems to carry out homogeneous environmental analyses over wide areas. The results that were obtained are compared with existing works to verify the reliability of the Coast-RiskBySea model.


There is a rising interest in the role of species diversity in ecosystem functioning and services, including productivity. Yet, how the diversity–productivity relationship depends on species identity and abiotic conditions remains a challenging issue. We analysed mixture effects on species productivity along site productivity gradients, calculated from a set of abiotic factors, in two biogeographic contexts (highlands and lowlands). We compared the productivity of 5 two‐species mixtures (i.e. 10 cases of mixed species) with that of monocultures of the same species. Five main European tree species were considered: sessile oak (Quercus petraea Liebl.), Scots pine (Pinus sylvestris L.), European beech (Fagus sylvatica L.), silver fir (Abies alba Mill.) and Norway spruce (Picea abies (L.) H. Karst). Our data set was compiled from the 2006 to 2010 French National Forest Inventory data base and covers 2361 plots including pure and mixed stands. Overall productivity of mixtures in highlands, that is European beech–Norway spruce, European beech–silver fir and to a lesser extent, silver fir–Norway spruce, was found to be higher than expected from the productivity of corresponding monospecific stands. Overyielding was mainly due to European beech for the first two mixtures and to silver fir for the third one. No effect of mixture was found for sessile oak–Scots pine and sessile oak–European beech stands in lowlands. Overyielding of sessile oak mixed with Scots pine was not strong enough to significantly increase overall stand productivity. Overyielding of European beech was balanced by an underyielding of sessile oak. The mixture effect changed along site productivity gradients for six cases out of the 10 studied, with a stronger and positive effect on sites with low productivity. The magnitude of this change along site productivity gradients varied up to 89% depending on the tree species. Synthesis. The nature of species interaction in mixtures with regard to productivity changes with species assemblage and abiotic conditions. Overyielding is strongest when species grow in highlands on less productive sites. A negative link between mixture effect and site productivity was found, in line with the stress‐gradient hypothesis.


Introduction Iran is one of the most vulnerable countries of the world to the earthquake. According to the seismic hazard map of Iran, almost the whole territory of the country is in relatively medium to high hazard area. Najaf Abad town is located in 30 km of Isfahan with the population more than 221000 people (in the year 2011) and is a middle town. It has the most important service center following Isfahan within the urban set of Isfahan. In terms of geology, Najaf Abad is located within Sanandaj-Sirjan zone regarded as one of the most active zones. Based on the conducted studies, the occurrence of earthquake over this zone is constantly possible. With respect to the seismo-tectonics map of Iran, this county is located within a zone with a relatively medium hazard and the event of historical earthquakes in 20th century. The basic trend of faults and dynamic structures in this zone indicate the relatively high rate of seismicity of this area. Regarding the importance of the issues related to the earthquake, the main objective of this research is to study and analyze the risk of Najaf Abad city exposed to the possible earthquake. Basically, meaningful weights have been dedicated to physical and social attributes for evaluating the seismic vulnerability to provide a local model for practical application of seismic risky analysis.


The objective of this thesis is the creation of a time bank website. In this website all the visitors will be able only to read the topics that users have create and also register as a user. All the registered users will be able to read all the topics; make a comment; make their own topics or advertisements and even declare their interest in an advertisement from another user. The administrator will be able to supervise all the topics; the advertisements and the users and block or even delete accounts of users if the administrator considers this necessary. Also, the administrator is responsible to transfer the time from one user to another so the deal is over if the one who received the services is ok with it.


The article considers the issue of the legislative consolidation of such concepts as favorable environment and environment conservation and shows the drawbacks of their definitions.


Following [1], for |ε| 1 we can define the Hilbert space Lμ = L2(X,μ), where X is the space of infinite sequences±1 and μ is a measure that corresponds to the groundstate of the HamiltonianH. The algebraA of quasilocalobservables,that is, theC∗-algebrageneratedby σx n, σ z n,−∞ < n < +∞, has a natural irreducible representation π acting in the space Lμ. The vector Ω = {1} ∈ Lμ defines a state ν on A by the formula ν(A) = Ω, π(A)Ω . By Robinson's theorem the formal Hamiltonian H defines a one-parameter group of automorphisms τt of A, and ν is invariant with respect to τt. Thus, τt defines a one-parameter unitary group Ut acting on Lμ. Its generator b H can be thought of as the operator realization of the formal Hamiltonian H. In order to find the spectrum of b H, we note that the non-local operators ("solitons")


When Su Dongpo lived in Huizhou,his political achievements,virtuer,prestige in literary circles and his good words and deeds were combined and mixed with the local beautiful environment,the hearts of the honest people and the folk culfure.This constifutes a unique and special cultural phenomenon while he staged in Huizhou,so comes the saying of the compatiability of Dongpo and Huizhou cultue.It is of great significance to develop and use this special culfue as it is beneficial to the promofion of the essence of the tradifional culture,to the promofion of commerce by art,to enhance the building of huizhou culfure industry,to publicize Huizhou and to make Huizhou's economy more prosperious.


ABSTRACT Socially desirable responding may cause differences between preelection polls and election outcomes. Bias-free preelection polls are, however, important because they influence election outcomes. Benefiting from a unique opportunity, we experimentally controlled social desirability using the Crosswise Model in a poll prior to the German federal election in 2013. We found that due to strategic voting, outcome expectations were related to voting intentions; the election outcome was therefore likely distorted by social desirability bias in preelection polls. We recommend using indirect questioning techniques whenever a vote for at least one of the competing parties may be perceived as socially undesirable.


A concrete/timber modular system is described which shows great promise in addressing the problem of the maintenance and rehabilitation of Australia's large stock of timber bridges and the provision of durable new structures. Details are given of laboratory and field experimental work which has been carried out as part of the development of the system, and a bridge rehabilitation case is described. (a) For the covering entry of this conference, please see IRRD abstract no. 895164.


Scorpion healthcare wine is a kind of imitation wine.Long-term storage or storage at low temperature of the wine may produce turbidity and light loss due to its complex ingredients.The effects of different treatment methods and clarifying methods on the stability and sensory quality of the wine were investigated through experiments.And the results suggested that 48 h freezing and clarification of semifinished product wine at-12 ℃ could improve the stability of product wine.Besides,proper control of the acidity of wine body and adquate pretreatment of scorpion could also improve the overall quality of product wine.


This article describes method of integration of simulation models, that being used in corporate information enterprises system. Integration's task is researched on example of real-time models, that being used in control's processes, diagnostic and making decisions. In base of presented method is used multiagent's way based on agents with knowledge. Multiagent's model of resources transformation process, that being supported multi-time modeling (discrete event, agent, queueing system), is used like dynamic model. For justification of the proposed technical solution of integration´s module, existing MQ services were analyzed. Domain ontology, that being used for semantic integration of data, that necessary for simulation of technological processes, business processes and logistics processes, is presented. The Java programming language is used for system development for providing cross-platform ability.


Phase formation in the aqueous system of uranyl nitrate, potassium hydroxide, and variable amounts of sulfuric and selenic acids has been investigated. Four different types of crystalline phases with variable S and Se contents were isolated and characterized using single-crystal X-ray diffraction (XRD) and IR spectroscopy. Topological analysis and information-based complexity calculations demonstrated the following: (a) the absence of a continuous solid solution in the system, (b) the absence of isotypic sulfate and selenate phases, and (c) the discovery of two layered topologies unprecedented among inorganic oxysalts.


ummary Gastric emptying undergoes complex regulation by the nervous system, which orgaizes in particular the inhibition of duodenum motility after a rise in intra-gastric pressure: the astro-duodenal inhibitory reflex. It was first shown in mammals that this reflex could be orgaized by a sympathetic ganglion, the coeliac plexus. The excitation of gastric mechanosensitive bres leads in this ganglion to the release of a neurotransmitter, which in turn activates ganlionic neurones leading to inhibition of the duodenum contractions. It rapidly became apparent hat this reflex presented striking properties since it was organized in the absence of action otentials along the nerve fibres. Then it was shown that the neurotransmitter released in the oeliac plexus was gaseous: nitric oxide (NO). The nature of the mechanism conducting, without ction potentials, the excitation along the nerve fibres was recently determined. This mechaism necessitates the integrity of particular areas of the neuronal membrane (the lipid rafts) nd the activation in cascade of the following second messenger sequence: ceramide, calcium, O and guanosine cyclic monophosphate (c-GMP). These results show how studies in biologial gastroenterology have led to the rethinking of one of the central dogmas in neuroscience ccording to which excitation is only conducted along the nerves by the action potential. 2010 Elsevier Masson SAS. All rights reserved.


Online POI recommendation strives to recommend future visitable places to users over time. It is crucial to improve the user experience of location-based social networking applications (e.g., Google Maps, Yelp). While numerous studies focus on capturing user visit preferences, geo-human interactions are ignored. However, users make visit decisions based on the status of geospatial contexts. In the meantime, such visits will change the status of geospatial contexts. Therefore, disregarding such geo-human interactions in streams will result in inferior recommendation performance. To fill this gap, in this article, we propose a novel deep interactive reinforcement learning framework to model geo-human interactions. Specifically, this framework has two main parts: the representation module and the imitation module. The purpose of the representation module is to capture geo-human interactions and convert them into embedding vectors (state). The imitation module is a reinforced agent whose job is to imitate user visit behavior by recommending next-visit POI (action) based on the state. Imitation performance is regarded as a reward signal to optimize the whole interactive framework. When the model converges, the imitation module can precisely perceive users and geospatial contexts to provide accurate POI recommendations. Finally, we conduct extensive experiments to validate the superiority of our framework.


In this paper, insulators of ±800kV UHVDC transmission lines in two types of typical climate conditions, namely extreme arid and humid, were taken as the research objects. The natural pollution accumulation tests were carried out to obtain the pollution accumulation characteristics of different string insulators under different climate conditions. The measured results show that the ESDD ratio of V-string composite insulator and I-string porcelain insulator is 0.68 in the extremely arid region, and that of V-string and I-string insulator is 0.72 in the humid region. The research results can provide a basis for the differentiated design of external insulation configuration of UHVDC transmission lines in different environmental areas.


Objectives:To investigate the effects of tamoxifen(TAM)on the growth of estrogen receptor(ER)negative thyroid carcinomas and the mechanisms involved.Methods:In vitro experiments,papillary thyroid carcinoma cells(IHH-4)and follicular thyroid carcinoma cells(FTC-133)were treated with tamoxifen in different doses and different lengths of time,using the dimethylthiazol-dipheltetrazolium bromide(MTT)method to observe the cell proliferation.Cell cycle and apoptosis were analysed with flow cytometric DNA studies.In vivo experiments the papillary thyroid carcinoma cells were injected into the nude mice subcutaneously,and the mice had been feed with TAM[5 mg/(kg·d)] daily since the second week.The tumor volumes were calculated weekly.Finally the mice were sacrificed and the tumors were weighed separately.Results:In vitro,TAM inhibited the proliferation of the IHH-4 and FTC-133 cell lines in dose-dependent and time-dependent pattern.TAM inhibited the growth of the IHH-4 and FTC-133 cell lines by blocking the cell cycle in G1 phase.Immunohistochemistry and RT-PCR studies showed the ER negative in both cell lines.In vitro,TAM also inhibited the growth of IHH-4 xenografts in nude mice.Conclusions:TAM inhibits the growth of thyroid carcinoma in vitro and in vivo.TAM acts independent of estrogen receptor and could be a potential choice for the treatment of the aggressive thyroid carcinomas clinically.


d-Mannose is an essential monosaccharide in the structure of glycoproteins, cell-surface glycoconjugates, and glycosylated phosphatidylinositide anchors. Several stud-ies have focused on plasma or serum mannose concentrations in patients with invasive candidiasis (1)(2), diabetes mellitus (3)(4)(5)(6)(7)(8), or congenital disorders of glycosylation type 1 (9).

There are various methods to determine mannose concentrations in human plasma or serum: enzymatic methods (4)(5)(7)(10), gas-liquid chromatography (2)(11), high-resolution liquid chromatography (12), gas-liquid chromatography–mass spectrometry (6), and capillary electrophoresis (13). None of these methods is fully suitable for routine use for various reasons, e.g., the incomplete or time-consuming elimination of the ∼100-fold excess of blood glucose, the use of instruments with limited availability, and the need for a large sample volume. We investigated whether a HPLC assay using an anion-exchange column would be appropriate for plasma mannose determinations. With the procedure described below, mannose could be rapidly and accurately determined in small amounts of plasma.

Boric acid, guanidine hydrochloride, sodium metaperiodate, and acetonitrile were purchased from Wako Pure Chemicals Co. Ltd. d-Mannose was obtained from Sigma Chemical Co.

We obtained blood samples from healthy individuals and from nondiabetic and diabetic patients after receiving their informed consent for this study. After collection of venous blood in tubes containing disodium EDTA (an anticoagulant) and NaF (a glycolysis inhibitor), plasma was separated by centrifugation. The plasma was mixed with an equal volume of 0.6 mol/L perchloric acid, a protein-precipitating reagent. The mixture was centrifuged at 8000 g for 10 min at 4 °C, and the protein-free supernatant was used for the analysis of mannose.

We used a HPLC system (Gulliver system with a JASCO PU-980 pump) equipped …


This article founded the worm model controls through the relationship by user's parameter.The parameter transforms input prompt through programming method,the system will produce conforms to the request new worm immediately so long as the user input correlation parameter according to the prompt,this method simplified the product design process greatly.


We provide approximation algorithms for some capacitated vehicle routing and delivery problems. These problems can all be viewed as instances of the following k-delivery TSP: given n source points and n sink points in a metric space, with exactly one item at each source, find a minimum length tour by a vehicle of finite capacity k to pick up and deliver exactly one item to each sink. The only known approximation algorithm for this family of problems is the 2.5-approximation algorithm of Anily and Hassin [ Networks, 22 (1992), pp. 419--433] for the special case k=1. For this case, we use matroid intersection to obtain a 2-approximation algorithm. Based on this algorithm and some additional lower bound arguments, we devise a factor-approximation for k-delivery TSP with arbitrary finite k. We also present a 2-approximation algorithm for the case $k = \infty$.
We then initiate the study of dynamic variants of k-delivery TSP that model problems in industrial robotics and other applications. Specifically, we consider the situation where a robot arm (with finite or infinite capacity) must collect n point-objects moving in the Euclidean plane, and deliver them to the origin. The point-objects are moving in the plane with known, identical velocities---they might, for instance, be on a moving conveyor belt. We derive several useful structural properties that lead to constant-factor approximations for problems of this type that are relevant to the robotics application. Along the way, we show that maximum latency TSP is implicit in the dynamic problems, and that the natural "farthest neighbor" heuristic produces a good approximation for several notions of latency.


This paper investigates the interaction of solitary waves (representative of tsunamis) with idealized flat-topped conical islands. The investigation is based on simulations produced by a numerical model that solves the two-dimensional Boussinesq-type equations of Madsen and Sorensen using a total variation diminishing Lax-Wendroff scheme. After verification against published laboratory data on solitary wave run-up at a single island, the numerical model is applied to study the maximum run-up at a pair of identical conical islands located at different spacings apart for various angles of wave attack. The predicted results indicate that the maximum run-up can be attenuated or enhanced according to the position of the second island because of wave refraction, diffraction, and reflection. It is also observed that the local wave height and hence run-up can be amplified at certain gap spacing between the islands, owing to the interference between the incident waves and the reflected waves between islands. © 2012 American Society of Mechanical Engineers.


ABSTRACT There can be no denying that it is entirely possible for a car-manufacturing company like Daimler to build and the deploy self-driving cars without hiring a single computational logician. However, for reasons we explain herein, a logician-less approach to engineering self-driving automobiles (and, for that matter, self-moving vehicles of any consequence, in general) is a profoundly unwise one. As we shall see, the folly of leaving aside logic has absolutely nothing to do with the standard and stale red-herring concern that self-driving cars will face exotic human-style ethical dilemmas the philosophers have a passionate penchant for.


The development of differing perceptions of the Line of Actual Control (LAC) has been one of the constant factors leading to the protracted dispute in the Himalayan border. Since the outbreak of war in 1962, recriminations and clashes between military forces have continued along the 3,488 km disputed area. Since 1980 both parties have continued to make efforts to resolve disputes with a fair and acceptable solution. Unfortunately, the initiations of these peace efforts have always been deadlocked. At first, in responding to India, China preferred to be passive. However, recently China has begun to respond with an assertive behavior. The deployment of army troops, military equipment, covert attacks, and massive infrastructure development was carried out by China in strategic Himalayan border. This study explores the changing of China's assertive strategy in the Himalayas by employing offensive realism and using qualitative approach. This study has found that the changing behavior of China's is related protecting its national interests and territorial sovereignty as well as a form of affirming the stability of China's dominance in the region. This study's results will provide an overview that there has been a shift in China's strategy for managing its border conflict with India.


Natural products and their related moieties have historically been incredible as a source of therapeutic agents. In last 5-10 years, research into natural products in the pharmaceutical industry has reduced, owing to issues such as the lack of compatibility of traditional natural-product extract libraries with high-throughput screening. It has long been recognized that natural-product structures have the characteristics of high chemical diversity, biochemical specificity and other molecular properties that make them favourable as lead structures for drug discovery, and which serve to differentiate them from libraries of synthetic and compounds. Recent advances in genomics and structural biology during the past decades are painting a clearer picture of the diversity of proteins targeted by natural-product molecules. Besides these, current lead generation strategies have led to a renewed interest in natural products in drug discovery.Drug discovery leading to robust and viable lead candidates' remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and ofstructural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. unique natural products major for The present article discovering new and effective compounds, an


Platinum film growth using Pt(PF 3 ) 4 precursors was investigated. The study focused on three aspects of film growth: conformality, adhesion and selective growth. Pt(PF 3 ) 4 deposited pure Pt films over a wide range of temperatures (∼200 to 400 °C). At 200 °C, the step coverage for a via with an aspect ratio of three was poor. Lower growth temperatures showed a significant decrease in the growth rate. In addition, these films had poor adhesion to the substrate as indicated by separation between the Pt and the substrate in cross sectional scanning electron microscopy images. Oxygen addition during Pt film growth from Pt(PF 3 ) 4 improved both film conformality and adhesion. With oxygen, the step coverage on the side wall was greater than 90 % The dependence of the film growth rate on oxygen varied with the growth temperature: the growth rate decreased at 200 °C, while it changed slightly at 260 °C when oxygen was added. The substrate effect on the initial growth rate was studied on various substrates. The initial growth rate on metals is much faster than that on other substrates. The growth rate decreased on various substrates in the order of iridium > titanium nitride > barium strontium titanate > silicon nitride > silicon oxide.


I offer a novel way of documenting the flow of power between the state and federal governments. Rather than look at programs or expenditures, I examine the behavior of elected officials. Assuming that ambitious politicians gravitate toward the locus of political power, I track the flow of elected officials in the American federal system. Specifically, I look at the career paths of more than 12,000 individuals who served in the U.S. Congress between 1789 and 2012. By analyzing the movement of elected officials between the state and federal levels, I confirm the prevailing story line on the evolution of American federalism while generating a measure that can be used to assess the relative distribution of power in the system across time.


It presents an apparatus and method for sensing the onset of stable combustion. Electrode positions the electrodes in a turbine combustion chamber to be exposed to Tebin combustion chamber of a gas. Electrode may be integrated with an igniter. Control module, the potential on the electrode is applied to determine whether to detect the combustion ionization signal, there is a vibration in the combustion ionization signal indicative of the start of generation or unstable combustion stable combustion state. Control module to notify simultaneously when the combustion process is indicated parameters to be in the beginning of the combustion instability, or a warning signal to notify simultaneously when the unstable state of the combustion process shown parameter. By adjusting the combustion parameter, direct the combustion process in a stable state.


In the past ten years, many Japanese manufacturers, especially automobile manufacturers, have opened plants in the United States. The Japanese have, in that time, increased their market share from one in five to nearly one in three cars that Americans drive. There are clear differences in Japanese and American business practices in the areas of organizational culture, leadership style, selection, training, employee attitudes, job satisfaction, and quality. American businesses must understand these differences and realize the most effective and efficient approach to produce goods and services that will fit in with our culture. The lessons we have learned from Japanese transplants and American corporations may have important implications to managers in public personnel management.


The aim of this paper is, firstly, to study under which conditions dumping occurs in a vertically related market, secondly, to investigate the effects of a tariff on an intermediate-good, and lastly, to consider whether the country suffering from dumping has an incentive to impose anti-dumping duty or not. The novelty of this paper is as follows: under the Bernhofen type model, dumping occurs only when the intermediate-good industry plays as Stackelberg leader to the final-good industry, and the import tariffs on the intermediate-good may cause dumping. Therefore, the best way to prevent dumping is the abolition of tariffs.


A two dimensional Fourier transform spin echo imaging sequence was used to obtain MRI T 1 weighted images from whole cooked carrots at temperatures between 18.6°C and 83.0°C. Sensitivity of temperature measurements from the images ranged from ±0.4°C to ±4.2°C, depending on the temperature of interest and the amount of signal averaging. Dynamic images were obtained with a 24 sec acquisition time. Such temperature images could aid in evaluation of models used for aseptic processing simulation studies. Faster imaging techniques could enable on line temperature maps for flowing particulates in aseptic systems.


Prediction errors (PEs) are a keystone for computational neuroscience. Their association with midbrain neural firing has been confirmed across species and has inspired the construction of artificial intelligence that can outperform humans. However, there is still much to learn. Here, we leverage the wealth of human PE data acquired in the functional neuroimaging setting in service of a deeper understanding, using meta-analysis. Across 263 PE studies that have focused on reward, punishment, action, cognition, and perception, we found consistent region-PE associations that were posited theoretically or evinced in preclinical studies, but not yet established in humans, including midbrain PE signals during perceptual and Pavlovian tasks. Further, we found evidence for PEs over successor representations in orbitofrontal cortex, and for default mode network PE signals. By combining functional imaging meta-analysis with theory and basic research, we provide new insights into learning in machines, humans, and other animals.


Heterosis is the foundation of modern maize breeding programs. Despite its importance in maize production, we know surprisingly little about the genetic basis of heterosis. Shull (1952) coined the term heterosis and defined it as: "... the interpretation of increased vigor, size, fruitfulness, speed of development, resistance to disease and to insect pests, or to climatic rigors of any kind, manifested by crossbred organisms as compared with corresponding inbreds, as the specific results of unlikeness in the constitutions of the uniting parental gametes." This definition is often interpreted as not implying a genetic basis for heterosis, because the definition basically describes the phenotype that results from crossing two different inbred lines.


List Of Tables List Of Appendices Acknowledgements Notes On Referencing And Abbreviations Introduction 1. Durham Cathedral Priory 1083-1540 2. Economic, Bureaucratic And Religious Developments And Reforms 1083-1540 3. The Corpus Of Accounting Material, Supplementary Sources And Key Questions 4. Rentals, Compoti, Status, And Other Documentary Forms 5. Debtors, Creditors And Financial Management 6. Accounting As A Management Tool 7. Monitoring And Conclusions Appendices Bibliography Index


This article is inspired by a need to clarify and appraise the law relatingto the sale of goods with particular attention to the market overtprinciple in Zambia. This will be done by conducting a comparativestudy between Zambia, South Africa, and Nigeria. The articleinvestigates methods for constructing a preferable legal regime forindividuals and businesses, particularly economic transactions. Itfurther assesses the Zambian Sale of Goods Act of 1893 (56 & 57 Vict.c.71) as it relates to the market overt principle. I also highlightweaknesses in the current law requiring remedial action.


INTRODUCTION: Although diffuse large B cell lymphoma (DLBCL) is considered a curable disease in the immunochemotherapy (ICT) era, about 40% of patients relapse or are refractory to first line treatment, representing an unmet clinical need. The role of upfront autotransplantation (ASCT) in high-risk cases is still debated, while its role in relapsed/refractory (R/R) disease is established in all guidelines. However less than 50% are actually cured with salvage ASCT (Gisselbrecht C et al, J Clin Oncol. 2010) and outcome of patients who relapse after ASCT is very poor (Crump M. et al, Blood 2017; Van Den Neste E et al, BMT 2017). Prognosis of aggressive lymphomas with characteristics intermediate with Burkitt's lymphoma (BCLU), recently reclassified (WHO 2016) as high grade lymphoma, unspecified with or without c-myc translocation, is less favourable. Regimens containing HD-MTX/ARA-C were generally used to treat these lymphoma subtypes as well as lymphoma with central nervous system (CNS) localization. Aim of this study was to evaluate the prevalence and outcome of R/R lymphoma after upfront or salvage ASCT or after HD-MTX/ARA-C regimens in the clinical care setting and to identify potential salvage approaches.
 PATIENTS and METHODS: We retrospectively analysed all consecutive HIV-negative patients seen at our Institute from January 2008 to December 2016 with de novo or transformed DLBCL, Primary mediastinal B-cell lymphoma or high-grade lymphoma/BCLU. First-line treatment used was R-CHOP/CHOP-like regimens. Consolidation with ASCT was performed in all high/intermediate-high IPI risk patients less than 65 years old, while salvage ASCT was performed after salvage ICT for R/R disease; HD-MTX/ARA-C regimens were used in DLBCL patients with CNS involvement or in BCLU cases. Relapsed or refractory patients after upfront or salvage ASCT or after HD-MTX/ARA-C were selected and their demographic and histological features as well as their outcome was analysed in term of duration of Response (DOR) from ASCT or MTX/ARA-C regimen to relapse and Overall Survival (OS) from relapse to the last follow-up or death. We recorded salvage treatments carried out according to age, performance status, available clinical protocols or international guidelines (more than one line in some patients).
 RESULTS: Among 571 patients consecutively seen during the time period, 156 (27.3%) proved refractory or relapsed after first-line treatment. ASCT was performed in 86 patients as consolidation (group A) and in 33 as salvage (group B). First line HD-MTX/ARA-C regimens were used in 16 patients (group C). Relapse occurred in 9/86 group A (10%), 20/33 group B (61%) and 8/16 group C (50%) patients respectively, representing 6.5% of the whole patients initially diagnosed. First relapse occurred after a median DOR of 4, 7, and 3.5 months in group A, B and C respectively. The main demographic and histological characteristics of relapsed patients are summarized in the Table 1, which also shows treatments used after relapse. Response rates in patients treated with curative intent were 29% (6/21). Mortality rates were high in all groups (78%, 90% and 100% respectively), with an OS significantly better in group A comparing to group B and C patients (p 0.0243) (Fig.1a) and in patients treated with curative intent compared to patients that received palliation (p <0.0001) (Fig.1b). Four patients only are currently alive, 2 in group A at 84 and 3 months after allotransplantation and 2 in group B at 15 months after HD-MTX/ARA-C for CNS recurrence and after R-DHAP ICT with lenalidomide maintenance still ongoing at month 36th as part of a study protocol. The cause of death for all patients was progression of disease.
 CONCLUSIONS: This analysis shows the very poor prognosis of patients with aggressive lymphoma relapsing after high dose therapy (ASCT or MTX/ARA-C). The recurrence of disease in these patients is early and salvage therapies are ineffective in most of the cases, although trying to treat these patients with curative intent shows a survival advantage over palliation. Patients treated with multiple lines of chemotherapy (group B) or with upfront HD-MTX/ARA-C (group C) have the worse prognosis. These data justify intensive follow-up programs during the first year after the end of therapy, and underline the need to develop new therapeutic strategies for this setting of patients, which could represent an ideal indication for CAR-T cell treatments.

 Rossi: GILEAD: Other: ADVISORY BOARD; SANOFI: Other: ADVISORY BOARD; NOVARTIS: Honoraria; ABBVIE: Other: ADVISORY BOARD; CELGENE: Other: ADVISORY BOARD; AMGEN: Other: ADVISORY BOARD; JAZZ: Other: ADVISORY BOARD; JANNSEN: Other; MUNDIPHARMA: Honoraria; BMS: Honoraria; PFIZER: Other: ADVISORY BOARD; TEVA: Other: ADVISORY BOARD; ROCHE: Other: Advisory Board; SANDOZ: Honoraria.


The functional characterization of H-PRUNE was performed using different approaches, in order to elucidate first the biochemical function of the protein, and then the correlation with other genes and the role in different tumour types. First, we identified and characterized H-PRUNE phosphodiesterase activity,
which is suppressed by dipyridamole. Interestingly, H-PRUNE interacts with NM23-Hl, an anti-metastatic protein involved in different processes as proliferation, differentiation and motility, suggesting us to investigate H-PRUNE possible correlation to tumour development and progression with respect to NM23-H1. Our study has consisted in elucidating H-PRUNE function in three different tumour types, as sarcoma, neuroblastoma, and breast cancer. Both sarcoma and breast cancer analyses revealed that H-PRUNE, localized into the cytoplasm, acts as a negative regulator of NM23-H1. In fact, both aggressive sarcoma subtypes and metastatic breast cancer showed high protein levels of H-PRUNE and low levels of NM23-H1, indicating its involvement in advanced stages of cancer. Moreover, we demonstrated that both the H-PRUNE phosphodiesterase activity and the H-PRUNE and NM23-H1 complex increase cell motility in the MDA-MB-435 breast cancer cell line. The overview of genes and pathways influenced by H-PRUNE overexpression in the MDA-MB-435 breast cancer cellular model has been performed in order to understand the molecular changes in tumour cells. Interestingly, we found high levels of H-PRUNE, localized into the nuclear compartment, correlated to high levels of both NM23-H1 and NM23-H2 (an isoform of the NM23 family) in advanced stages of neuroblastoma. We identified a new function of H-PRUNE as a transcriptional regulator of NM23-H2 and we postulated a transcriptional mechanism of regulation, including activation of NM23-H1 by NM23-H2 and of NM23-H2 by H-PRUNE. This study evidences H-PRUNE function, as a regulator of NM23-H1 anti-metastatic function by two different mechanisms of action, correlated to the different compartmentalization of H-PRUNE protein.


Fingerprints are used to identify human and for crime discover. They are used to authenticate persons in order to allow them to gain access to their financial and personal resources or to identify them in big databases. This requires use of fast search engine to reduce time consumed in searching big fingerprint databases, there for choosing searching engine is an important issue to reduce searching time. This paper investigates the existing searching engine methods and presents advantages of AVL tree method over other methods. The paper will investigate searching speed and time consuming to retrieve fingerprint image. Experiment shows use of AVL tree is the best searching algorithm.


The establishment of active sites as the frustrated Lewis pair (FLP) has recently attracted much attention ranging from homogeneous to heterogeneous systems in the field of catalysis. Their unquenched reactivity of Lewis acid and base pairs in close proximity that are unable to form stable adducts has been shown to activate small molecules such as dihydrogen heterolytically. Herein, we show that grafted Ru metal–organic framework-based catalysts prepared via N-containing linkers are rather catalytically inactive for H2 activation despite the application of elevated temperatures. However, upon light illumination, charge polarization of the anchored Ru bipyridine complex can form a transient Lewis acid–base pair, Ru+–N– via metal-to-ligand charge transfer, as confirmed by time-dependent density functional theory (TDDFT) calculations to carry out effective H2–D2 exchange. FTIR and 2-D NMR endorse the formation of such reactive intermediate(s) upon light irradiation.


Background: Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden cardiac death (SCD) in the young. Late gadolinium enhancement (LGE) seen on contrast-enhanced cardiovascular magneti...


Submitted for the MAR08 Meeting of The American Physical Society Interactions among microdroplets at the water-air interface CHUAN ZENG, Department of Physics, University of Massachusetts Amherst, ANTHONY D. DINSMORE — There has been a great mystery concerning the origin of measured long-range attraction among microparticles at fluid interfaces. Recent theoretical work1 showed that electrostatic interactions should not lead to long-range attraction, but the possibility remains that attraction arises from an irregular contact line on the particles' surfaces. Replacing the solid particles with liquid droplets eliminated surface roughness and thus reduced the complexity of the system. We captured micron-sized oil droplets at water-air interface and measured the interaction between them. The dynamics of droplets at interface were imaged using optical microscopy, from which the droplets' motions were tracked and analyzed. The interaction between two isolated droplets was calculated from their trajectories through the Markovian dynamics extrapolation method developed by J. C. Crocker and D. G. Grier2. We acknowledge support from NASA through the Fluid Physics program (NRA 02-OBPR-03-C) and from the NSF-supported MRSEC on Polymers (DME0213695). 1 See, for example, M. Oettel, A. Dominguez, and S. Dietrich, Phys. Rev. E 71, 051401 (2005). 2 J. C. Crocker and D. G. Grier, Phys. Rev. Lett. 73, 352 (1994). Chuan Zeng Department of Physics, University of Massachusetts Amherst Date submitted: 27 Nov 2007 Electronic form version 1.4


This paper argues that the ascendancy of neo-conservative social vision in the United States stems in significant part from the failure of its critics to lay out a compelling alternative. It suggests that efforts to avoid the totalizing trap of the metanarrative have led the critics of modernity, including many in the Public Administration Theory Network, to focus on partial and piecemeal social alternatives rather than on broader vision. It argues, however, that the oppressive consequences of modernist notions of progress follow not from their comprehensiveness, but from the ethnocentric character of their universalist claims. It uses the "I have a dream" speech of Martin Luther King Jr. to demonstrate how a vision of enhanced social practices can be both great and compelling and yet avoid the dangers of the metanarrative. It suggests a crucial role for anti-modernist theorists of public service in articulating such a vision.


In today's world there is a tremendous increase in the number of users using the Internet. As a result the e-commerce websites have been emerging to encourage the users of Internet. But these e-commerce websites are facing the problem in recommending the items to the users. In view of this challenge, an Agglomerative Hierarchical Clustering for Hybrid Recommender Systems approach is proposed in this paper which aims at recruiting similar items in the same clusters to recommend items which are similar both at content as well as at rating. Technically, this approach can be performed in two stages. In the first stage, the available items are divided into small-scale clusters, for further processing. And in the second stage, Hybrid Recommender Systems algorithm is imposed on one of the clusters. As the number of the items in a cluster is much less than the total number of the item available on the web, it is expected that the online execution time of Hybrid Recommender Systems can be reduced. At last, to verify the availability of this approach several experiments are conducted.


Summary Data are presented which demonstrate that atropine blockade of cholinergic effects in vascular beds is reversible. The reversibility of the blockade is evident in the vasodilatation and blood pressure fall which result from postatropine injections of ACh. It appears to be related not to time, size of dose, or interval between doses, but to the number of times ACh is allowed to compete for the receptor site.


Nonfossiliferous red clay can be used for elucidating long‐range environmental changes, although such studies were limited so far because of the difficulty in precise age estimation and extremely low sedimentation rates. We conducted an environmental rock‐magnetic study of Cenozoic red clay at the Integrated Ocean Drilling Program Site U1365 in the South Pacific Gyre. Magnetostratigraphy could be established only above ∼6 m below the seafloor (mbsf) (∼5 Ma). Below ∼6 mbsf, the ages of the cores were transferred from the published ages of nearby Deep Sea Drilling Project Site 596, which is based mainly on a constant Cobalt flux model, by intercore correlation using magnetic susceptibility and rare earth element content variation patterns. Rock‐magnetic analyses including first‐order reversal curve diagrams, the ratio of anhysteretic remanent magnetization susceptibility to saturation isothermal remanent magnetization (SIRM), and IRM component analyses revealed that magnetic minerals consist mainly of biogenic magnetite and terrigenous maghemite, and that the proportion of the terrigenous component increased since ∼23 Ma. We consider that the increase reflects a growth of eolian dust flux associated with a northward shift of Australia and the site to an arid region of the middle latitudes. The increase of the terrigenous component accelerated after ∼5 Ma, which may be associated with a further growth of the Antarctic glaciation at that time. This is coeval with the onset of the preservation of magnetostratigraphy, suggesting that the primary remanent magnetization is carried by the terrigenous component.


India is a country of communal diversity. The existence of such society demands mutual understanding among its religious sects. But more than once the harmonious chord has strained and a series of communal riots has maligned her history –in the recent decades the rot is a bit speedy. Wherein lies the solution to such communal problems? Probably, Mahesh Dattani, the first Indo-English playwright to win the prestigious Sahitya Academy Award in 1998, might have had one in his mind. The present paper is a humble endeavour to analyze Dattani's play 'Final Solutions' (1992) and unearth the touching issue of schism in relationship due to misunderstanding between the two major religious factions- the Hindus and the Muslims. 'Final Solutions' by Mahesh Dattani is a play which frames the time and its burning problems. In this play particularly the issue of communal harmony is raised and what takes the play to a different level is that the playwright tries to cater a solution to the problem by bringing the followers of the two religions on an even keel. Whether it remains a conjecture or whatever, is a different matter altogether, but, no doubt, Dattani tries. In 'The Shadow Lines', Amitav Ghosh failed to reach any solution of the raging problem of the divide between the Hindus and the Muslims, in 'Riot' Shashi Tharoor struck at the root of the problem and in 'Train to Pakistan' Khushwant Singh concludes with a ghastly scene of death where two minds of two different religious sects though got united in love but in reality could not. In the conclusion of this play by Mahesh Dattani, there is a striving for reaching an amicable solution but it is still dubious, rather an expiatory note dominates. Which then the Final Solution is?


Several application domains are collecting data using Internet of Things sensing devices and shipping it to remote cloud datacenters for analysis (fusion, storage, and processing). Data analytics activities raise a new set of technical challenges from the perspective of ensuring end-to-end security and privacy of data as it travels from an edge datacenter (EDC) to a cloud datacenter (CDC) (or vice versa). This article discusses the security threats in EDCs and CDCs by dividing the complete network structure into three layers: perception layer, network layer, and application layer.


In the daily combat readiness duty, faced with emergencies, time window left for decision-making is limited, far from enough to research and design a totally new COA (Course of Actions). However, using the state-of-the-art AI technologies, it is yet unable to autonomously generate COAs of trust. From the perspective of practicality, it is effective to improve emergency response efficiency, by making use of historically accumulated COAs. Similar problems have similar solutions, which is especially suitable for fields with incomplete knowledge systems and limited data accumulation. An intelligent method of COA recommendation is proposed, which can accurately recommend appropriate COAs based on current mission requirements, battlefield situation, and preferences. Based on the recommended COAs, user can form a new COA more efficiently, faced with emergencies. As a solution for AI technology supported combat decision making closer to practical, the method has certain reference value.


The article analyzes the organizational and pedagogical conditions for the formation of professional competences of a higher education graduate, emphasizes the role of students' fundamental preparing for the implementation of the content and tasks of the pedagogical process. The necessity of integrating content on the system approach basis by substantially structuring the content of the educational material from the fundamental subjects is substantiated; the approach to the interpretation of the system knowledge notion as specified is developed in the minds of students from the basic scientific concepts through the basic scientific theories to the main consequences of this theory and their place in the future the profession It is established that an important component of the integration of knowledge into the systematization of their systematization is the allocation of generalizing concepts in the unified system of the fundamental subject content, theories and laws which the existing causal and consequential correlations in the system are identified with. On the basis of the theoretical analysis, practical approaches to the implementation of the systematic method during the integration of the fundamental subject content are defined, the means of realization of the integrative approach (integrated structural-logical schemes, generalization tables, integrative didactic units, integrated educational control cards) and their didactic tasks are characterized.


We recently read a very interesting and important study in the Journal of Maternal-Fetal & Neonatal Medicine entitled: "There is reduced immunohistochemical staining of placental aromatase in severe neonatal opioid withdrawal syndrome [1]." In this study, the authors investigated the effects of opioid exposure during pregnancy on placental immunostaining intensity of aromatase (i.e. CYP19A1). Additionally, the authors related severity of neonatal opioid withdrawal syndrome (NOWS) to immunostaining intensity of aromatase in placentas from opioid-exposed pregnancies of women undergoing medication-assisted treatment for opioid use disorder with either methadone or buprenorphine. Aromatase plays a major role in placental metabolism of methadone [2] and buprenorphine [3]. This investigation is important because understanding the interplay between these opioids and placental aromatase will better inform us on the determinants of fetal opioid exposure and NOWS caused by methadone and buprenorphine. The authors reported a reduction in aromatase immunostaining in opioid-exposed placenta compared to unexposed controls. We were particularly interested in their additional finding that babies with severe NOWS had lower placental aromatase immunostaining than babies with non-severe NOWS. Based on this finding, the authors hypothesized that "reduced aromatase immunostaining results in altered aromatase function within the placenta, leading to higher circulating active opioid transferring from the placenta to the fetal compartment," and offered that this phenomenon may cause higher rates of severe NOWS. However, the increased NOWS is more likely explained by a greater representation of treatment with methadone than buprenorphine in the group that developed severe NOWS. Methadone induces more severe NOWS than buprenorphine [4], and this effect is thought to be mediated by the higher efficacy of methadone than buprenorphine to activate the mu opioid receptor. We acknowledge the possibility that methadone inhibits or downregulates placental aromatase to a greater degree than buprenorphine, which in turn may permit greater methadone distribution to the fetus, contributing to the greater severity of NOWS observed following methadone treatment. However, we think this is unlikely because buprenorphine has an approximately 10-fold lower Ki than methadone to inhibit aromatase activity [5]. We would be interested in a comparison of placental aromatase immunostaining as a function of pharmacotherapy (methadone vs. buprenorphine) to determine whether methadone downregulates aromatase to a greater degree than buprenorphine. The sample size of the dataset used in the study is likely large enough to power this analysis, and we encourage the authors to conduct the analysis and report their findings. We feel it is important to highlight these alternative interpretations because we are concerned that a casual reader of this article may simply conclude that placental aromatase plays a protective role against NOWS. The reader should take care not to assume a causal relationship between low placental aromatase and severe NOWS based on this study. Sincerely,


Up until now, hydroxyethyl starch (HES) solutions have mainly been indicated as "volume expanders". Recent unfavorable reports of these solutions such as probability of kidney injury or inducing coagulopathy have relatively ejected these solutions in many centers, particularly in European countries. Despite several confirming studies, multiple anecdotal letters or reviews has challenged total disappearance of these colloids from medicine practice. Also, some novel observations emphasized the distinguished ability of HES to preserve the microvascular integrity even at the presence of an inflammatory process. Despite extreme statements has been published demanding immediate suspension of these fluids from the market, it seems logical to revise the most recent studies which may declare new pathways to approach HES family of solutions.


The X-test is a two-sample test, defined as follows. Let xi,**, x, and y.1..*, yh be independent observed variables. Let ri,* * *, r, be the rank numbers of xi,* * *, x, among the x's and y's. Put g + h = k. Let 4 be the (cumulative) normal distribution function and ' = -t the inverse function. Put


ABSTRACT The presidency of gender in the Anglo-American taxonomy of sexualities historically has been haunted by the irruption of "other" parameters of medicalization, censure, and caesura, not in the least absolute and relative measures of age. Where today's clinical psychologists feel the need to age-specify adult homosexuality in such Hirschfeldian terms as androphilia, however, the felt need is indeed still essentially clinical. That cosmopolitan expressions such as homosexual, LGB, or queer rarely require such specifications relies on a protracted and today, arguably, complete disarticulation of sex/gender and age/maturity as parameters of sexual orientation, accreditation, and mobilization. Notably disconnected discursive frames gave voice to this Anglophone crystallization of "the normal homosexual" (circa 1950–1980): criminological, psychiatric, psychophysiological, and psychodynamic typologies of "sexual deviation" (variably tending to correlate, align, or subsume same-sex and age-disparate intimacies); territorializing apologias of gay, but also of "Greek," "pederast," and "man-boy," socialities; anthropological-historical exotification of "age-stratified homosexualities"; and mostly European, proto-queer critiques of all "bourgeois" sexual classification.


A semi-commercial 100 m3 marine recirculating system (RAS) was designed, based on the results of a 5 m3 experimental system. The system was stocked with gilthead seabream (Sparus aurata). After 200 days, the fish in the semi-commercial system had a similar weight (about 330 g) and density (78 kg/m3) and identical survival (99%) and FCR (1.8) as similar fish grown in a flow-through system (FAS). Annual production in the RAS was calculated as 90 kg/m3. Seawater consumption was 3.5-4 m3 per kg fish produced, resulting in an average water exchange rate of 80% of the system volume per day. While this is relatively high compared to freshwater RAS, the marine RAS required only 10% of the sea water consumed in an FAS. Since sea water is an inexpensive input, water consumption was a minor component of the total production costs in the RAS (approximately 6%). The economical analysis for a theoretical 500 ton/y farm showed that the main capital investment components would be the rearing volume (fish tanks) and the biofiltration unit, representing over 60% of the total investment. The highest production costs would be feed, fingerlings and return on the investment, in that order, representing over 50% of the production costs. CO2 stripping may limit further intensification because the limited surface area of the tank limits the number of paddlewheels that can be used. Also, the DO/TAN ratio may be a factor limiting achievement of a higher nitrification rate and reduction of the biofilter size. Based on the results of this study, a 100 ton/y pilot plant is currently being designed as a model farm.


Objective Understanding of the past six years epidemiological characteristics of notifiable disease in Gaozhou,to provide the basis for developing appropriate prevention and control measures.Method From 2004 to 2009 reports of notifiable diseases in Gaozhou were analyzed.Results The average annual incidence rate of notifiable disease in the past six years in Gaozhou is 147.5472 / 10 10000,with an upward trend in incidence,mainly in B category,particular of the respiratory diseases,blood and sexually transmitted diseases with a trend of increase.Tuberculosis and hepatitis B with the highest incidence and remain at the top of the list.The incidence rate of male is higher than that of female,and it is relatively high of the elderly and young people in age of 20~29.Conclusions From now on,the main task for the prevention and control of infectious disease in this city is to improve the mechanism and management of reporting the notifiable diseases.At the mean time we should strengthening the knowledge and training of the staff.We should also focus on the prevention and control of major infectious diseases such as tuberculosis,hepatitis B and sexually transmitted diseases.


Abstract : The problem of angular resolution is formulated in a statistical decision theoretic context. A tutorial discussion of decision theory and its application to resolution is presented, and an explicit signal processing radar system is derived whose resolving properties approach an optimum. Computer simulation tests show that the system is capable of reliably resolving targets as close as a quarter of a 3-db beamwidth in the presence of noise and system errors. (Author)


Looper system of hot strip rolling mill is electro mechanic and hydraulic pressure system. Because of dynamic parameters uncertainties and complex structure, it's very difficult to setup the model. However, its control performance has directly relative to the strip product quality. In this paper, robust non-fragile guaranteed cost controller is designed for looper system. For a class of uncertain discrete system, based on Lyapunov stability theory and linear matrix inequalities, a sufficient condition is presented for the existence of robust non-fragile guaranteed cost controller. Furthermore, this solvable approach for guaranteed cost controller is given by the feasible of linear matrix inequalities. This non-fragile guaranteed cost controller is applied to looper systems of hot strip rolling mill. Simulation results show the efficiency of the designing method.


This thesis is divided in two parts. In the first part a geometrical modelling approach has been developed in tandem with weaving parameters. The reinforcements were woven on a modified conventional loom to study the geometry of these structures. Their weaving has been described in detail. The weaving parameters have been correlated to the modelling approach. The meso structural modelling approach is capable of predicting essential reinforcement geometrical characteristics at meso structural level without being too complicated. Furthermore, mechanical characterization of 3D interlock reinforcements has been carried out in such a way that a track of mechanical properties during the complete production cycle has been maintained. A novel parameter called strength transfer coefficient was proposed which allows better understanding of the influence of structural parameters on the final properties of the composite. In the second part of the thesis an online structural health monitoring system which is composed of a textile based sensor and signal amplification and treatment module, has been developed. This system is capable of detecting structural deformations in the composite as the sensor is integrated during the manufacturing of the reinforcement and can follow its deformation pattern when composite is subjected to tensile loading in a real time.


In this paper I select the 54 listed companies in stock market A which were announced because of not disclosing the important items in time in 2005 to analyze the market response to this affair.The result illustrates that the stock prices fall in the day of the announcement significantly,but the time of sustainment is short,and the stock prices of studied sample don't descend significantly compared with the selected control samples.


Objective:To research the effects of Isatis root polysaccharide(IRPS)on T subpopulations of piglets in the immune response to porcine reproductive and respiratory syndrome attenuated virus vaccine.Methods:T lymphocytes subpopulations in the piglets pheripheral blood were tested at different time with porcine reproductive and respiratory syndrome attenuated virus vaccine(PRRS vaccine)with or without IRPS by cytofluorometry.The serum titer of special antibody were tested by PRRS antibody test kit.Results:IPRS could improve the proportion of CD3+ and CD8+ in the piglets pheripheral blood and boost the production of special antibody.Conclusion:The results suggested that IRPS co-inoculated with PRRS vaccine could enhance immune response of pigs.It is a potential immunostimulatory for pigs.


The current study was conducted to assess the toxic effect of cypermethrin-induced reproductive toxicity in male rabbits. cypermethrin 10% (64mg/kg) was used as orally .twenty five male rabbit was divided into two groups (cypermethrin group 15 animals and control group 10 animals) were killed at 3 periods (3 weeks, 6 weeks, and 9 weeks). Sperms were collected from the tail of epididymis by slicing and rinsing pressing techniques of each epididymis in 5 ml of physiological normal saline at 37 c̊ in a small glass dish, then a drop of suspension was put on slide then stained by eosin-nigrosin stain. The presented results showed that there was significant sperm deformities in head, mid peace and tail of cypermethrin group as compared with control group. in conclusion, the study observed that cypermethrin have toxic effect on sperm morphology. It was therefore recommended that the use of Cypermethrin be applied with caution in animals as it may affect the fertility.


OBJECTIVE
To investigate the role of Fas/Fas ligand (FasL) in tum orgenesis, immune escape, counterattack in colonic cancer.

METHODS
Fas and FasL were measured by immunohitochemistry in 52 colon cancer, 27 adenomas, 28 ulcerative colitis (UC), 30 normal colon tissues and 23 lymph node metastases of colon cancer. In different FasL expression regions, the apoptosis of tumor cells was detected by TUNEL.

RESULTS
(1) The expression rate of Fas was lowest in colon cancer tissue. It was lower than that in adenomas and UC, while it was highest in normal tissue. Compare of Fas, FasL was highest in colon cancer tissue, lowest in the normal tissue. The FasL in adenomas and UC were higher than that in the normal tissue. (2)Expression of Fas/FasL was not correlated with the typ e of tumor histology, but it was correlated with Dukes'stage, tumor differentiation and lymph node metastasis.(3) In the same tumor tissue, FasL expression was not even. Apoptotic rate of tumor cells was higher in FasL positive region(n = 25)(81.2%) than that in FasL negative region(n = 25)(47.4%)(P < 0.01). (4) FasL was strong positive in all 23 lymph node metastases of large intestine cancer, and more than 75% tumor cells were FasL positive in each tissue.

CONCLUSION
Fas/FasL play an important role in tumorgenesis, immune escape, counterattack in colon cancer.


Abstract An essential oil was obtained from fresh leaves of Neomitranthes cordifolia, collected in South Brazil, and analyzed by GG and GC/MS. Twenty-four compounds were identified and-it represents 78.9% of the oil contents, of which β-carvophyllene and (E)-β-farnesene were the major components.


This paper describes the components of the post-traumatic syndrome. The pathological state of fat macroglobulinemia by occlusion of arteriolar terminal branches of vital organs causes the fat embolic syndrome. The main physiopathological problem is pulmonary insufficiency in an acute or subacute form. The cerebral embolus is second. The symptomatology varies and is not characteristic. According to their importance they were described as minor or major in the diagnosis of fat emboli. Only recently, treatment for the fat emboli syndrome has been initiated, consisting mainly in supportive measures, respiratory care and anti-inflammatory drugs, mainly cortisone.


- Water spinach is one of the popular vegetables in Indonesia because it has fast-growing properties and is relatively fast in harvesting. Currently, some farmers are cultivating water spinach hydroponically because the technique is more efficient. In the growth of kale, farmers usually always look directly at the garden. So to see from a distance, a water spinach growth monitoring test will be carried out using the Internet of Things (IoT) combined with sonic bloom technology taken from dangdut, jazz, murottal music with a frequency of 4000 Hz. Sonic Bloom is a technology development that utilizes sound waves to accelerate the opening of the leaf mouth (stomata). The parameters for testing the productivity of water spinach were plant height, room temperature and water temperature. Network performance testing parameters are delay, throughput and packet loss. The purpose of this study was to compare the results of three types of music that affect water spinach and water spinach without sonic bloom technology and to test the results of network performance. The application of sonic bloom technology was successfully implemented on water spinach with the most influential result being jazz music with a height of 25.47 cm. Very good network performance in this study is testing with delivery every 5 minutes for 1 hour observation with a distance of 1 meter with a delay value of 568.36 ms, throughput 3403.06 bps, and packet loss of 0 %.


Abstract Novel variable configuration spacecraft (VCS) can change its configuration by on-orbit assembly or the motion of the mechanism according to the requirements and missions, and the multibody dynamics analysis is performed to obtain the corresponding theoretical lowest values of the mechanical properties of force-bearing structures for the VCS module. In the meantime, to meet the actual use requirements for VCS, novel force-bearing structures are designed optimally and fabricated successfully. The corresponding experimental values of the mechanical properties for the force-bearing structures are also tested and investigated, which are compared to the corresponding theoretical values via multibody dynamics analysis. This paper is part of a large project on the development and preparation of the novel force-bearing structures applied in the next generation of VCS.


This report documents the status of a laser-based underground guidance system for tracking and controlling the movements of underground mobile mining equipment. This research is part of a multiple project effort at the U.S. Bureau of Mines to increase mine safety and efficiency by developing technology for computer-assisted mining. Guidance systems, which can track and control the movements of underground mining equipment, are essential during computer-assisted mining operations. A continuous mining machine at the Bureau's surface test facility served as the test-bed for initial development and experimentation of this guidance system. Subsequently, a continuous mining machine in an underground mine served as the platform for in-mine experimentation. The first section of this report includes details of the laser sensors, communication network, and computer hardware. The next section includes experimental results, which show the system capable of accurately tracking and controlling the tram maneuvers of a continuous miner underground. The final section discusses conclusions and recommendations. 'Electrical engineer, Pittsburgh Research Center, U.S. Bureau of Mines, Pittsburgh, PA.


To recommend the best colleges for students based on novel content-based filtering and keyword map algorithms. Classification is performed by content-based filtering (N=10) over keyword map algorithm (N=10). Sample size is analysed using GPowerby using pretest power as 0.9 and alpha 0.05. Mean accuracy of content-based filtering (83.96%) is high compared to keyword map algorithm (78.51%). Significance value for accuracy and loss is 0.355 (p>0.05). The mean accuracy of the college recommendation system in content-based filtering is better than keyword map algorithm.


This book examines a variety of topics relating to structural transformation, such as why such transformations are associated with persistently high unemployment; the 'flying-geese' theory introduced by Japanese economist Kaname Akamatsu in the mid-1930s; mutual, two-way dependence of structural transformation and food security; a competitiveness-based view of structural transformation; the link between world trade and structural change from 1800 to present; the relationship between financial reforms, financial development, and structural change; sustainable structural change in the context of global value chains; and the commonly used strategies to build effective clusters and industrial parks. The book also discusses the specific problems that arise when composing an index of structural change and development, and suggests ways to address them; how structural change can be formally modelled in New Structural Economics (NSE); and some of the key elements of the knowledge accumulated in development economics. Furthermore, it identifies three key economic forces that drive structural transformation: the first emphasizes income effects, while the other two both emphasize relative price effects. The experiences of regions and countries such as Latin America, the West African Economic and Monetary Union (WAEMU), India, Egypt, Viet Nam, China, Korea, Taiwan, Ethiopia, and Tanzania with respect to structural transformation are also analysed. Finally, the book considers what is harmful in the existing structures, what goals we want any new structures to serve, and what structures would serve the chosen goals.


The intensity of x rays from an Fe/sup 55/ source passing through a cell containing heavy oil was measured by means of a Geiger-Mueller courter. A 1-Mc Fe/sup 55/ source and a vinyl chloride cell (4 mm in length and having a mylar window 100 mu thick) were used. Disturbances from the high energy gamma radiation from a considerable amount of Fe/sup 59/ contamination in the source, caused the experimental sensitivity to become worse than the estimated sensitivity for absorption analysis using the 4-mm long cell. Other elements in the heavy oil had littie effect on the determination of S, and the observed error was <0.1% for samples containing <4% of S without correcting for the density and mass ratio of C/H in samples. (OID)


We propose an uncertainty quantification framework that applies structural identifiability and global sensitivity analysis to reduce the number of parameters to be estimated. This preprocessing is necessary as failure to reduce the parameter set to the identifiable and influential parameters led to a more difficult estimation problem and increased parameter uncertainty. To highlight these effects, we varied the preprocessing analysis that we used to reduce the set of free parameters for the MAPK model in the bistable regime. In particular, we tested two additional cases; one where we only used structural identifiability analysis to reduce the parameter space and another where we did not perform any preprocessing. Based on our previous experience, we predicted that parameter uncertainty would increase as we eliminated each parameter reduction preprocessing step.


The flexural strength - the resistance to fracture - of raffia palm fiber-cement composites for low cost roofing tiles was investigated. The composites were prepared at varying sand-to-cement ratios (1-5), water-to-cement ratios (0.4-0.8) and fiber volume fraction (0-4%). The flexural strength of the samples was determined and a statistical model based on a three-level full factorial experimental study was developed. The model was optimized using the optimization toolbox of MATLAB 7.0 to determine optimal values of factors that maximize flexural strength. The results show that addition of raffia palm fibre to cement composites increases the flexural strength by more than 100% in comparison with the control, with zero percent fibre volume fraction. The most significant factor is sand-to-cement ratio and the flexural strength has a local optimum (maximum) for a sand-to-cement ratio of 1, water-to-cement ratio of 0.4 and fiber volume fraction of 2.0525%. Reducing the values of the first two factors will increase the optimum flexural strength. It is recommended that raffia palm fiber be used for the manufacture of wall, ceiling and roofing tiles based on the above specification.


Vocational English has been an important part of public English course in higher vocational colleges.Therefore,strengthening vocational English construction is an inevitable trend of public English course reform in higher vocational colleges.This paper explores vocational English in terms of property,course design and teaching principle and studies the feasibility of carrying out multi-type English teaching in higher vocational colleges.


The utility model discloses an electric prayer wheel, which comprises a base, a motor, a rotary table, and a scripture wheel placed on the rotary table, wherein the motor is arranged in the base, and the axle head of the motor protrudes upwards and out of the base, and is connected with the rotary table. The electric prayer wheel is characterized in that bulges capable of limiting the left and right swaying of the scripture wheel are arranged on the surface of the rotary table wherein the scripture wheel is placed. The utility model has the advantages of simple structure, good stability, and aesthetic appearance.


This study aimed to examine the impact of the experience of auditors, professional commitment, obedience pressure, and ethical values of the perception of ethical considerations organizations using multiple regression analysis.The aim of this study is the Financial and Development Supervisory Agency Representative Riau Province. This research is a survey method. Respondents in this study is the auditor BPKP-RI Representative Riau Province. The number of samples was 82 auditors. There are five variables in this study consisted of four independent variables namely the auditor's experience, professional commitment, obedience pressure, and ethical values of the organization, and the dependent variable is the perception of ethical considerations. According to the research results, it can be concluded that professional commitment, obedience pressure and the value of the organization's ethics significantly affect the perception of ethical considerations, while the auditor's experience did not significantly affect the perception of ethical considerations. The coefficient of determination indicates that the auditor's experience, professional commitment, obedience pressure, and ethical values of the organization affect the dependent variable (the perception of ethical considerations) of 45.4%, while 54.6% is influenced by others factors. Keywords: auditor's experience, professional commitment, obedience pressure, ethical values of the organization's and perception of ethical consideration.


Compact forms of neutron interrogation could prove useful for instances when a large scale active interrogation system is not ideal. Field ion desorption structures provide the opportunity to produce ions by creating beams of deuterium or deuterium and tritium ions which strike a target doped with deuterium or deuterium and tritium, thus producing a neutron.


: In China, English teaching has always been focused on improving students' English application ability and giving consideration to cultivating students' intercultural communication ability. Based on the unique characteristics of the three English skills reading, speaking and writing, this paper designs the corresponding class activities with "careers" as the theme, in an effort to improve students' learning enthusiasm. Through the learning of these skills lessons, students can further improve their cultural confidence and cross-cultural communication skills.


Study Design: A case report. Objectives: To report a rare case of minimally invasive spine surgery after sublaminar wiring fixation with Luque rods. Summary of Literature Review: In the past, sublaminar wiring fixation with Luque rods was believed to be an effective fixation method; however, the development of transpedicular fixation resulted in the discontinuation of this method. Currently, instead of classical surgery using a broad incision, minimally invasive spine surgery is performed, which has a multitude of advantages. Material and Methods: Initially, the patient underwent Luque sublaminar wiring and posterolateral fusion. After 25 years, minimally invasive TLIF and percutaneous transpedicular fixation were performed for the adjacent segmental spinal stenosis. Results: A good bone union is developing with an excellent clinical outcome, 14 months after the surgery. Conclusions: We report a very rare case of a patient who underwent Luque sublaminar wiring and then, 25 years later, had spine surgery with minimally invasive techniques.


Freedland fails to make an adequate distinction between, on the one hand, emails and letters that are directed to an author and point to differences of fact or opinion, and, on the other, responses that attack the editorial policy or the financial interests of the journal and seek to prevent expression of the views objected to.1 …


Sideband phenomenon is an obscure aspect of gear design and has been found to produce poor sound quality resulting in customer dissatisfaction and warranty returns. For continuous product improvement, a synchronous sampling (SS) data acquisition (DAQ) system evaluates the vibration and acoustic signals of a helical planetary gear set within a transfer case. An optical encoder is mechanically locked to this rotating system and outputs a pulse train according to a specific angular resolution. This signal controls the analog to digital (AID) conversion as an external sample clock. This synchronized acquisition removes the signal processing error inherent within the resampling of time data from fixed frequency DAQ systems. In addition, vectorial averages are implemented to reveal hidden synchronous content from the Root-Mean-Square (RMS) noise floor. The SS DAQ system displays these improvements of the order domain representation from a vibration and acoustic analysis of the transfer case under steady state conditions.


The paper reports the study of extraction of sand from the deposit. The objective of the research was achieved by taken soil and water samples from seven locations in Akure. Strip mining was used to excavate sand in all the deposits. The samples were analyzed for physical and chemical properties which include temperature and colour and the amount of macro and micronutrients such as Ca, Mg, K, Na, Fe, Cu, Pb, Mn, Zn, Cl, Acidity Alkalinity and Organic matter. The result show that the subsoil are acidic (pH varies from 5.0 – 7.0). While the topsoil varies from slightly acidic to highly basic (pH ranges from 5.7 – 8.1). Cultural, Aquaculture and Nature trial recreation are however suggested for reclamation.


We experimentally demonstrate epsilon-near-zero "photonic wires" supporting optical modes with effective wavelengths 10 times larger than the light's free space wavelength and improved propagation lengths. Design, fabrication, and characterization of the wires will be discussed.


Using monthly composites of the ocean color sensor Coastal Zone Color Scanner, we generated time series of pigment concentrations for three transects and 22 locations off Baja California and the southern California coast in order to describe the signature of the Ensenada Front and its seasonal and interannual variability. We used averaging maps of pigment concentrations for nonEl Nino and El Nino years to compare the differences between those periods. Our results show that the Ensenada Front signature has an M-shape and its spatial and seasonal displacement can be followed using the 0.25 and 0.5 mg m � 3 chlorophyll-a concentration isolines. For El Nino years the M-shape is not very clear because of the strong penetration of Subtropical Pacific Waters along Baja California and the California coast, except during April, when upwelling is stronger. Such features were confirmed using SeaWiFS LAC images of chlorophyll-a concentration.


The number or offspring,weight (per thousand) and stature are three important parameters for evaluating breeding effect of Scleroderma guani.We measured and analyzed by experiments for this three parameters und the condition of different inoculation parasitoid-host ratio.The results in- dicated;different amounts of female wasps and their hosts have different effects on the breeding. The amount of female wasps has no remarkable effect on breeding,but obviously affects weight( per thousand) and stature of their F_1 generation;The amount of the hosts has remarkable effects on the amount,weight (per thousand) and stature of wasps F_1 generation.In industrial breeding,if 12mm×50mm tubes are used as a unit,it's more common to use 5 larva of Saperda populnea and 4-5 female wasps.Sometimes,the amount of female wasps and hosts in single tube could be based on the density of target pests and the amount of female wasps released on one plant.


As a part of the Tesys Rail Project authors have developed a parametric and computationally affordable model of a railway DC line in order to analyze the complex energetic interactions arising between different travelling vehicles. In order to fully exploit the features of the proposed approach and its capability to investigate complex operating scenarios, the authors have further developed the model by including a wider variety of on-board functionalities and a more extended list of simulated vehicles. In this research work, the authors expose some improvements of a previously developed High Speed train model (based on the ETR 1000) and the development of additional models of older Italian High Speed Trains, such as the ETR 500, which are still in service on Italian High Speed lines.


The charging and relaxation kinetics of pyrolytic boron nitride (BN) substrates, boron nitride with an aluminum oxide (BN/Al2O3) coating, and thermally annealed alumina-coated boron nitride (an–BN/Al2O3) were investigated under low-power electron irradiation (5<incident energy E0<20  keV and incident flux Ji=10  nA·cm−2 at room temperature) in the CEDRE (Chambre d'Etude De Revetements Electrises, in French) facility at ONERA–The French Aerospace Lab. Surface potentials of each ceramics configuration were measured over time using the Kelvin probe method. The influence of coating and annealing treatments to limit charging is discussed in this paper. A thorough study of an an–BN/Al2O3 sample was carried out under a critical electron flux (E0=20  keV and Ji=750  nA·cm−2) to assess the degradation kinetics of the material's electrical properties. The characterizations of an–BN/Al2O3 samples were performed before and after electrical aging at CIRIMAT (Centre Inter-universitaire de Recherche et d'Ingenierie des ...


Results of astrometric studies with the 76 cm Thaw red-light-refractor and the Multifiltered Astrometric Camera are presented for 21 stars. The parallax estimates range from 259.3 mas for Teegarden's Star to 10.3 mas for the high-velocity star LSPM J2321+4704. This paper includes parallaxes for late M dwarfs, white dwarfs, and a high-velocity star. We also report the apparent binary motion of LSPM J0607+7372.


A teacher's work with children of preschool and early school age focuses on achieving the teaching and educational objectives, as well as those related to childcare. The tasks include, among others, supporting pupils in shaping the image of the world, recognising different values and criteria,as well as methods of choosing them, obtaining basic social skills, and shaping moral and religious attitudes. The educator is obliged to show the children universal values and ethical principles. They also have to present role models and motivate their pupils to imitate them. All of this fosters an image of sanctity among children. When it comes to making decisions regarding the shaping of the image of sanctity among children, the teacher is restricted by educational law, especially the core curriculum of general education, as well as the school's curriculum. This restriction applies mainly to the objectives and content of teaching and education. However, in matters of methodology, the teacher has many possibilities for creative action. They may exceed the methodologies suggested by educational law and design their own teaching innovations. With regard to shaping the image of sanctity among children, of particular note are All Saints' Day balls, Angel Days, educational games and activities, family fairs, saints' parades, competition and stage productions.


Background and aims: we aimed to detect the outcome values of adding fentanyl,
dexamethasone and sodium bicarbonate to mixture of local anesthetic
in peribulbar block for vitreoretinal surgery. Methods: 120 adult ASA I & II
patients, admitted for vitreoretinal surgery under peribulbar block were included
in this comparative study. This study included 4 groups: Group I: (30)
patients using a mixture of 1 ml normal saline, 4 ml lidocaine 2% plus 4 ml
from bupivacaine 0.5% 20 ml vial containing hyaluronidase 1500 IU. Group
II: (30) patients using a mixture of 1 ml of sodium bicarbonate (from 1 ml sodium
bicarbonate 8.4% diluted in 10 ml normal saline), 4 ml lidocaine 2%
plus 4 ml from bupivacaine 0.5% 20 ml vial containing hyaluronidase 1500 IU.
Group III: (30) patients using a mixture of 1 ml fentanyl 20 μg (from a mixture
of fentanyl 100 μg diluted in 5 ml normal saline), 4 ml lidocaine 2% plus
4 ml from bupivacaine 0.5% 20 ml vial containing hyaluronidase 1500 IU.
Group IV: (30) patients using a mixture of 1 ml of 4 mg dexamethasone (1
ampoule = 8 mg/2 ml), 4 ml lidocaine 2% plus 4 ml from bupivacaine 0.5% 20
ml vial containing hyaluronidase 1500 IU. We measured the onset and duration
of anesthesia, IOP, eyelid and global akinesia, postoperative pain by numerical
pain rating scale, first analgesic requirement and postoperative side
effects. Results: No significant differences were detected among the four
groups as respect to age, sex and the intraocular pressure (IOP) before the
anesthesia block. While the intraocular pressure (IOP) after the anesthesia
block there was a significant difference, as IOP was markedly decreased postoperatively
in group II compared with other groups. As regard to the onset & duration of anesthesia there was significant difference among all groups,
there was rapid onset and prolonged duration of anesthesia in group III compared
with other groups (1.77 ± 0.63 & 5.03 ± 0.89) respectively. As regard the
onset of lid akinesia there was significant difference among the four groups
with better outcome in group III, as in group III represented the most rapid
onset of lid akinesia. As respecting to the onset of global akinesia there was
significant difference among the four groups. There was better outcome in
group III as it represented more rapid onset of global akinesia compared with
other groups. There were significant differences among the four groups as regard
postoperative pain all over 6 hours, better results were in group III (0.27
± 0.69) compared with group I (2.23 ± 1.17), group II (2.00 ± 1.70), group IV
(0.67 ± 0.71). As regarding to the first time for analgesic requirement there
were significant differences among groups, there was no request for analgesia
with better outcome in group III with increasing need to the analgesic medication
in group I compared to group II and group IV. As regard side effects
postoperatively there were few side effects in all groups with few numbers of
cases in groups III only one patient. Although these differences in number of
patients are not significant among the four groups. Conclusion: Addition of
sodium bicarbonate to local anesthetic mixture was the best way in lowering
the IOP other than other groups and addition of fentanyl to local anesthesia
provided more rapid onset and duration of anesthesia, more rapid onset and
duration for lid and global akinesia, less pain, less analgesic requirement and
minimal side effects than the other groups.


Carcinoma of the cervix is the most common malignancy associated with pregnancy. The frequency of cervical cancer is estimated to range from 1/1,200 to 1/10,000 pregnancies. The symptoms of cervical cancer are not specific and can be mistaken as frequent symptoms associated with other pathologies of pregnancy. The diagnostic procedure is similar to the one which should be proposed to unpregnant women. The treatment of cervical cancer depends on gestational age. The final treatment and further prognosis is carried out after delivery. The authors present the case of a 35-year-old woman at 34 weeks of gestation diagnosed with Stage IB cervical cancer. Treatment was delayed until fetal maturity and an elective cesarean section was performed at 36 weeks' gestation, followed by a radical hysterectomy, bilateral salpingo-oophorectomy, and a pelvic lymphadenectomy. Patient underwent adjuvant radiochemotherapy and brachytherapy. Recurrence of neoplastic process was found after one year.


Hot machining is a type of cutting operation that an external heat source is used to pre-heat and consequently reduce the yield strength of the workpiece material. In this study, the conventional and hot turning of AISI630 hardened stainless steel, which is widely used in energy equipment, aerospace, and petrochemical industries, have been evaluated in both numerical and experimental methods. Simulation of the turning process is carried out by finite elements method (FEM) using AdvantEdge software. To predict chip morphology and cutting forces, the 2D and 3D FEM analyses have been used, respectively. The numerical analysis showed that hot turning in 300°C causes a reduction of 28% in cutting forces and consequently decreases stressed on the cutting tool. It is found that the main factor affecting the fluctuations of the cutting forces in turning of hardened AISI630 is the saw-tooth formation phenomenon (chip segmentation) as well as the shear band generation due to thermal softening of the workpiece material. Furthermore, the relation between cutting force fluctuation and the machined surface roughness has been investigated applying numerical analysis and experimental data. The results of roughness measurement revealed that hot turning in 300°C reduces the machined surface roughness up to 23%. In addition, it has been observed that hot turning technique decreases side flow and surface damages in comparison to conventional turning.


Introduction Erigeron davisii (Cronquist) G. L. Nesom is a diminutive perennial tap rooted composite with white ray flowers that is endemic to the canyon grasslands of the lower Snake River and its tributaries (Nesom 2004 and 2006). It occurs on rocky ridges and slopes, basalt outcrops, and sparsely vegetated woodland openings or edges in eastern Oregon and western Idaho (Nesom 2004). E. davisii was first described as a variety of Erigeron engelmannii by Cronquist (1947) from a collection made by Ray J. Davis in 1941 on White Bird Summit in Idaho County, Idaho. Nesom (2004 and 2006) found that the differences between E. engelmannii and E. engelmannii var. davisii were great enough to warrant recognition at the species rank for E. engelmannii var. davisii. The geographic range of E. davisii is also distinct from the range of E. engelmannii. Their two ranges do not overlap. Erigeron davisii is still referred to as E. engelmannii var. davisii in GeoBOB which follows the outdated taxonomy found in the USDA PLANTS database.


This article designs and implements a 3D moving target positioning and tracking system by using ultrawideband (UWB) technology. The result of the two-way ranging by the time difference of arrival (TWR-TDOA) positioning algorithm is adopted to result in a new resolution that is to resolve the hyperbolic equations. The proposed algorithm is applied to outdoor and indoor scenarios. To minimize the effect of the sensor layout, this article proposes a simplified multi-population genetic algorithm (MPGA) to obtain the optimum distribution of anchors, which can rapidly reduce the number of search iterations. To resolve the low stability of the TDOA algorithm in outdoor and indoor scenarios, the Kalman filter algorithm is utilized to improve the stability and positioning accuracy of this system and a good simulation effect is achieved. The test results show that the system's positioning error is far less than that of using other methods. The whole system has a feature of high precision, high stability, low complexity, and low cost.


This paper presents an effective application of expert system for analysis Cardiac disorder like arrhythmia. An electrocardiogram (ECG) is a bioelectrical signal which records the heart's electrical activity verses time. It is an important diagnostic tool for assessing heart functions. The technique used is feature extraction and neural network for signal analysis. The processed signal source came from the MIT-BIH arrhythmia database which was developed for research in cardiac electro-physiology.
 Research in the field of mathematical science and physics is concentrating more on mathematical analysis of system comprising multiple elements that interact in complex ways. These factors gave birth to a major research trend aimed at clarifying the structure and operating principle inherent in the information processing system of human being and other animals and constructing an information processing device based on these structures and operating principle. The term "Neurocomputing" is used to refer to the information engineering aspect of this research. Artificial Neural Network (ANN) has been widely accepted tool for complex decision making problems. This is a powerful tool for medical diseases decision-making. ANN has ability to take its own decision based on its trained data. This paper concludes with a discussion in analysis cardiac disorder and future usage of artificial neural networks in the area of biomedical.


In this paper, we have developed digital models of mechatronic drives for robots and production machines for the most common laws of acceleration variation and typical loads. The examples show that there is a minimum peak instantaneous power in the areas of acceleration and dynamic braking at certain values of additional parameters for all motion laws under consideration and for the given cycle time and travel. Such parameters include the acceleration/deceleration times, the coefficient of exceeded minimum possible acceleration or the coefficient of uniform motion. Based on studying mathematical models, we have proposed methods for assessing the effectiveness of selecting motion laws and their parameters with respect to the lowest maximum power consumption. The relationship between the maximum instantaneous power and the drive power consumption for different motion laws has been established.