Abstract The Totara Bridge is a multi-span Howe Truss bridge built in 1908 as part of the Hokitika to Ross rail line on the West Coast of New Zealand's South Island. The rail line transported goods and passengers until its closure in 1980. Howe Trusses were a common style of bridge across New Zealand on both roads and railways, however few remain. The Totara Bridge is an impressive example of this style of bridge, having five trusses of 80 ft spans. The West Coast Wilderness Cycle Trail passes along this section of old rail line. The Westland District Council considered the option of incorporating the old Totara Bridge into the trail, or constructing a new crossing over the Totara River. The absence of maintenance since closure of the line meant the some elements of the bridge were in poor condition; however the Council made the commendable decision to retain the bridge and carry out necessary repairs to make it safe for public use. This decision, along with necessary design input, has restored one of the few remaining examples of was a common style of bridge in early New Zealand, and enabled its continued use for many years to come.


Mastitis is one of the major and keen parameter for quality and quantity of milkproduction. The recent study was conducted to estimate the occurrence rate of mastitis in four differentseasons of the year and its therapeutic cure in Llivestock Experiment Station Nili Ravi Bhunikey. Forthis purpose, the total of 1188 milk samples were screened for mastitis through California MastitisTest. Out of total 1188 milk samples, the prevalence rate of mastitis was 9.7% (27/279) in winter, 14%(40/286) in spring , 7.2% (23/320) in summer and 6% (18/303) in autumn respectively. An overallprevalence rate of mastitis was 9 %( 108/1188).The screened positive samples were subjected toculture on culture media. Seven antibiotics were selected for the fortitude of antibiotic sensitivityagainst the cultured organisms. Antibiotics used in current research were Gentamicin, Enrofloxacin,Amoxycillin, Norfloxacin, Tylosin, Oxytetracycline and Chloramphenicol. The efficacy of thedifferent antibiotics was checked by the configuration of the zone of inhibition. The outcome showedthat the incidence of mastitis was greater in spring and lower in autumn. From selected antibiotics,Enrofloxacin and Gentamycine have resulted in more effective against the cultured organism.


The choice and justification of the polymeric material is made for the fuel tank. It is established a possibility of linear polyethylene application with technology of fluoration as material for production of the fuel tanks with high barrier properties, that is with low permeability in relation to hydrocarbons. The main technological operations for the production of plastic fuel tanks carried out by rotational molding are described.


An ultrashort-pulse reflectometry (USRM) has been applied to the inductively coupled steady-state plasma (ICP) for density profile measurement. A reflected wave from ICP is directly recorded into a digitizing sampling scope and is analyzed by the signal record analysis (SRA) method. From repetition of the measurement, we have obtained the time evolution of the density profile. In order to apply the USRM and SRA method to high density plasmas such as core region of the Large Helical Device plasma, generation of the pulse with higher frequency up to 90 GHz is essential. We have utilized a frequency upconverter and an active doubler for this purpose. We confirmed the generation of the upconverted pulse in the range of 60–90 GHz and the second-harmonic frequency in the range of 26–40 GHz. Time of flight measurements have been preliminarily performed with a metal target.


Today, sustainability is considered as a high priority and it is on the management agenda for
major corporations. It has experienced an increase in customer demand, pressuring
corporations to act in a more sustainable way to stay relevant and competitive. One industry
that is experiencing an increased request to act sustainable is the construction industry. The
construction industry differs quite a lot from other industries since it is project based and built
on temporary relationships. Subcontractors are temporarily engaged in the projects, often by
a main contractor, to perform tasks which they are specialized in. The subcontractors
additionally engage their own respective subcontractors. This makes it harder to control and
ensure that all involved actors are acting in a sustainable way due to the multiple tiers of
contractors and complex nature of the projects.
A technology that recently has gotten a lot of attention is the blockchain technology. It can be
described as a shared, distributed ledger technology, which was created as an enabler for
the cryptocurrency Bitcoin. The technology has, in the recent years, been widely discussed
as a potential business enhancer. It can for example provide immutable record-keeping;
enables the usage of smart contracts; and enhance transparency within the network. The
blockchain technology has the potential to disrupt current business practices and decrease
the required amounts of trust needed in business relationships.
Because of the increasing demand of sustainability practice within the construction industry,
technologies that can enhance it becomes of interest for further investigation. Therefore, this
thesis has been investigating if the blockchain technology can enhance sustainability for
contractors within the construction industry. To achieve the purpose, data has been gathered
from literature, interviews as well as benchmarking of existing blockchain solutions in
business. The empirical gatherings resulted in identifying seven issues related to
sustainability within the construction industry, and relevant information regarding blockchain
that is not mentioned in the literature. The issues found in the empirical data were analysed
by a framework which consist of three blocks. The first one concerns whether the issues
found are within the scope of sustainability. The second block concludes, using a proposed
blockchain decision tree, if the issues have a potential blockchain solution. The final block is
a SWOT analysis, where the blockchain solution for each issue is evaluated in isolation.
The issues of non-sustainable material used by the contractor, undeclared work, accidents,
employee payment and limited contractor base where concluded to potentially be prevented,
or mitigated, with a blockchain solution. It is, however, still a immature technology that needs
to be further developed and understood in order to bring out its true potential. Several of
these issues can be prevented, or mitigated, by the same kind of blockchain setup, which
makes it to a more profitable alternative than separately evaluating them.


There has previously been given a one-parameter family of pairs of Heron triangles with equal perimeter and area. In this note, we find two twoparameter families of such triangle pairs, one of which contains the known one-parameter family as a special case. Second, for an arbitrary integer n > 2 we show how to find a set of n Heron triangles in two parameters such that all triangles have equal perimeter and area.


paper presents a quality-driven software architecture design method. The method produces architectural descriptions at two levels of abstraction. Both the levels are described using four similarly named views: structural, behavior, deployment and development. More importantly, the method enables the realization of quality attributes by means of quality requirements and quality scope, which leads to the selection and localization of architectural styles and patterns. Quality attributes can be traced from the quality requirement definitions to architectural descriptions, wherein each of the views concerns certain quality attributes. Keywordsquality, architecture, design methods, QAD


The invention relates to a process for preparing high-purity diketene, which overcomes the defects of low purity of ketene, low purity and poor safety of diketene products formed by absorbing and polymerizing ketene, as well as complex process, high cost and high acetic acid content of raffinate in the concentration recovery of dilute acetic acid. The process for preparing high-purity diketene is suitable for absorbing and polymerizing ketene dimer at low temperature on the basis of adopting stable acetic acid cracking conditions and deep refrigeration to remove impurities from cracking gas and generate pure ketene gas, adopting a film evaporator to further purify diketene products at low temperature under low pressure, and adding stabilizers after introducing polymerization inhibitor and diketene for refining during the absorption and polymerization of ketene in order to improve synthesis safety and the stability of products in storage tanks. Meanwhile, the dilute acetic acid produced in the process reasonably matches the temperature of each point of a stripping section through a sensitive plate technique, improves the water-carrying capability of butyl acetate, and greatly reduces the concentration of acetic acid in concentrated raffinate.


Rural households are often dependent on rivers, springs, boreholes or standpipes some distance from their homes for their daily water requirements. Water drinking and domestic use is consequently stored in containers in-house which are prone to post-collection contamination. The objective off the study was to determine the most likely origin or place off introduction off E. coli associated with post-collection contamination in rural households, by assessing the degree off genetic relatedness off E. coli present in the stored water and other environmental samples. E. coli isolates were obtained using either mFC agar with confirmation of indole production (44 isolates) or Colilert(R)-18 (52 isolates). Amplified fragment length polymorphism (AFLP) fingerprinting was applied to determine the genetic relatedness of E. coli isolated in-house storage containers, drinking cups, hand-swab samples, cattle dung and from the source water (spring water). DNA fingerprints of E. coli produced a number of clusters (>85% similarity scores calculated with the cosine coefficient). Identical E. coli genetic patterns were observed at closely linked points within the domestic pathway off water handling, such as between hand-swab and drinking-cup samples, between storage container and source isolates, and between drinking cups, source water and storage containers. The results indicated that AFLP fingerprinting could be applied to determine the genetic relatedness of E. coli isolated closely linked points within the domestic pathway off water use within a household. However, the high genetic diversity observed E. coli bacteria isolated the different water and environmental samples tested in this study, hampered the identification of post collection points of contamination.


The excitation function of the elastic scattering of $sup 16$O by $sup 12$C has been measured from 15MeV to 33.7MeV on the last maximun of the angular distribution. Resonances are seen at 17.3 MeV, 19,7 MeV and 22.5 MeV and analysed as shape resonance with an L - dependent absorption. (FR)


The aim of this study is to explore the impact of digital storytelling (DST) on the academic achievement and democratic attitude of 4th-grade primary school students and to reveal their experiences in the DST process. The study was conducted with a mixed-method approach. The quantitative part of the study adopted a pretest and posttest quasi-experimental design with 30 students. In the qualitative part of the study, two focus group interviews were carried out with 15 students in the experimental group. The quantitative data was collected through an academic achievement test and a democratic attitude scale. The qualitative data was obtained through two focus group interviews. Descriptive analysis, t-test, and qualitative content analysis were used for evaluating data. Results revealed that the students in the experimental group performed significantly better than the students in the control group in terms of academic achievement and democratic attitude. Focus group interviews highlighted that DST is effective in promoting constructivist learning and lack of experience is the biggest problem in the DST process


Sacha Inchi (Plukenetia volubilis L., Euphothiaceae) is a potential oilseed crop for its wealth of seed oil rich in omega-3 fatty acids. The present study describes the isolation and characterization of two Sacha Inchi oleosin genes (PvOle1 and PvOle2) encoding oleosin proteins. Full length cDNAs of PvOle1 and PvOle2 were comprised of 829 and 763 nucleotides, encoding 143 and 139 amino acids with a molecular mass of 15.2 kDa and 14.8 kDa, respectively. Comparative and bioinformatic analysis revealed the divergence of PvOle1 and PvOle2 in their amino acid sequence and hydrophobic profiles and also the L-form of both oleosin proteins. Phylogenetic analysis indicated the possible occurrence of duplication (PvOle1 and PvOle2) before the speciation of Sacha Inchi. Semi-quantitative RT-PCR expression analysis revealed the high expression of PvOle1 and PvOle2 transcripts in the developing seeds. Further, using yeast as a heterologous expression system, we investigated the effective role of PvOle1 and PvOle2 in yeast lipid body accumulation, which was confirmed by SDS-PAGE and Immunoblotting analysis. Taken together, the characterization, expression profiling and heterologous functional analysis of two oleo sin genes (PvOle1 and PvOle2) will be helpful for further studies concerning the role of oleosin proteins in metabolic protein engineering in Sacha Inchi. (C) 2013 Friends Science Publishers


THE excavations at Curium have yielded a large number of site-finds, amounting to over 750 separate varieties, nearly all in bronze, which illustrate local circulation over nearly two millennia, though the representation of different periods is somewhat uneven. From the period before Alexander certain bronze issues, which cannot be accurately attributed on internal grounds, were found in sufficient concentrations to suggest that they may have been minted at Curium itself (nos. 3, 4, 5, and 8). After Alexander for two and a half centuries the coinage of the island was Ptolemaic, and a list such as this gives valuable help in separating the Cypriot from the Egyptian issues. The excavations produced remarkably little coinage of the first two centuries A.D., whether from the provincial issues of Cyprus itself or from the imperial series. With the third century, however, there is a marked increase, and it is suggested that part of the large issues of Elagabalus and Severus Alexander, usually attributed to Syrian mints, may have been produced in Cyprus (nos. 144-6). A further increase follows in the fourth century with the mint of Antioch providing nearly twice as much coinage as either of the two next commonest, Alexandria and Cyzicus; Rome, Constantinople, and Nicomedia occur quite often, but the remaining mints in only isolated specimens. In the sixth century, though the numbers of coins are much smaller, it is Constantinople which provides three times as many coins as any other single mint, and nearly as many as all the other mints together. The series ends with a few coins of the medieval kings of Cyprus and several imported pieces of the later Middle Ages. In a series of site-finds such as this few outstanding single pieces are to be expected; notable here are the three bronze medallions of the late second century, of which one was hitherto unpublished (no. 230). Full notes and discussion accompany the list of coins and over a hundred examples are illustrated.


I use data on 252 U.S. firms between 1994 and 2000 to study the relationship between audit committees and boards of directors with financial reporting quality. I initially document several changes in committee and board profile during the sample period. Results from logistic regressions suggest that measures of audit committee and board structure are related to earnings quality in a manner that is generally consistent with the predictions of agency theory. This study contributes to extant knowledge by employing different earnings quality measures from prior studies, and by expanding the range of audit committee attributes deemed important in determining audit committee performance.


This paper theoretically researched the common used air-conditioning with primary pump and terminal variable flow control and the flow of invariable chilled-water refrigeration systems,and theoretically explained that when the number of the running units reduces,the phenomenon of large flow and little temperature difference still big although the right selection of the chilled-water pumps and cooling water pumps and the proper design of the systems.Then,this paper discusses the problems result from oversize water flow,and some related suggestions and solutions were proposed.At last,the paper investigated the impact on the system by the phenomenon and gave some advises to resolve this problem.


Based on data from the Semarang City Fire Department in 2013-2016, 1028 fire incidents took place in Semarang City. This incidence reached its highest in 2015 with 399 cases of fire which caused material losses of up to IDR 398.3 billion. Based on these figures, Semarang City possesses the highest incidence rate of fire cases in Central Java Province. However, studies on the risk and mitigation of fire hazard disasters in Semarang City still need to be carried out. This study aims to identify fire risks, to mitigate the disaster's hazards in Semarang City, and to provide recommendations for arranging relevant buildings and the environment. The method used in this study is a qualitative descriptive method, in which interviews are conducted with key persons, with the utilization of GIS analysis to assess the risk of fire. The results of this study exhibit that in Semarang City, 14 villages have a high level of fire hazard risk, one of which is Rejosari Village which has the highest level of fire risk. This occurred mainly because historically, there have been many fire incidents in this area and even claiming several lives. The density of buildings and the difficulty of access further increase vulnerability in the case of fire. Nevertheless, the inhabitants still lack an understanding of this hazard. Accordingly, the fundamental mitigation to be carried out in Rejosari Village is to increase community comprehension and to consider the addition of fire protection and safety facilities, including hydrants, in densely populated buildings and areas, in order to reduce the risk of fire hazards.


In order to form the embedded devices with the power to exchange information with one another is important for the arrival of the web of Things (IoT). Several existing communication protocols are designed for little devices including the message queuing telemetry transport (MQTT) protocol or the constrained application protocol (CoAP). However, most of the prevailing implementations are convenient for computers or smart phones but they are doing not consider the strict constraints and limitations like error reporting, scalability, extensibility, portability, and support for little clients. During this proposed system, the IoT server has designed to figure on any quality of network and where the server, which should remain fairly small and straightforward, completes the most important part of the processing. The goal is to implement MQTT 5.0 publish/subscribe protocol in a simple, fast, elegant, and customizable way in order that it is often the answer for the IoT trend needs and to beat the prevailing protocol limitations. The IoT server runs on TCP by default but is often run on any ordered, lossless, bi-directional protocol.


Flu Watch is the world's largest community cohort study of influenza occurrence and immunity for several decades including 118,000 person weeks of active follow up. The presentation will describe methodology, seasonal rates of infection and disease, population immune profiles through the different waves of the pandemic, severity of pandemic and seasonal influenza, and the role of T cells in immune protection.


Some unaccepted results are caused by the existing allocation methods with complex allocation factors, i.e., there is actually no active/reactive loss, but the active/reactive loss appears in the allocation results. That sort of the fictitious phenomena is due to ignoring the important fact that any node voltage is determined by all the injection powers, thus, it is approximate to take the node voltages as constants. A better solution method proposed in the paper is considering the loss allocation as the question of how to allocate the nonlinear function value (loss) to its independent variables (injection powers). The solution of the nonlinear equation for loss allocation is not unique mathematically. The goal and the principle proposed are to provide correct economic signals and to decrease the whole loss of the network.


The author tries to elaborate that the non- linear architectural exploration represents the important direction of world architecture based on the evolution of architectural theory system in 20th century. The non- linear exploration is the reflection of Complex Science Theory on architecture. It depends on the computer technology to solve complicated issues. Its results of design would be non-linear volumes, which are dynamic, flowing, non-standard forms. At the same time, author emphasizes that the non-linear design advocates being back to the site and starting from the phenomena in order to avoid new formalism. And also the author points that diagram is the core logic in the whole design process.


OBJECTIVE
The interleukin-1 receptor antagonist (IL-1RA) contributes to tumor survival and progression in multiple cancer entities. IL-1RA polymorphisms influence IL-1RA expression patterns and function. A known polymorphism was correlated with clinical outcomes in melanoma patients with particularly aggressive disease.

METHODS
DNA of 343 controls and 97 melanoma patients with poor prognostic indicators (time from diagnosis to death, nodal status, metastasis) was analyzed for a variable number of tandem repeat polymorphisms (VNTR) of the IL-1RA gene. Five alleles containing two (allele 2), three (allele 4), four (allele 1), five (allele 3) or six (allele 5) 86-bp repeats were targeted via PCR amplification.

RESULTS
Genotype 1/2 is less common in the melanoma patient group vs. the control (28.8% vs. 39.6%; p = 0.06). Significant was the stage of the melanoma in order to predict the survivability (p = 0.008). The 1/1 and 1/2 genotype appeared to have lower hazards ratios than the 2/2 genotype (p > 0.05).

CONCLUSIONS
Compared to the general population, the distribution of alleles coding for IL-1RA is different in melanoma patients. This alteration and the potential impact on tumor protein function and systemic inflammatory response may warrant further investigation.


Abstract : The Rapid Force projection Initiative (RFPI) Technology Program Management Office (TPMO) of the Research Development and Engineering Center (RDEC) required a Local Area Network (LAN) to provide the management and technical support of several demonstrations within the Advanced Land Combat (ALC) Science and Technology (S&T) program. In support of this effort UAH was contracted to perform the teaks defined below to complete the installation of the LAN for the RFPI TPMO.


Timely identification of outliers occurring in key performance indicators (KPIs) of mobile cellular networks is crucial for prompt action to unexpected events. The KPIs of cellular networks typically exhibit seasonality and trend effects and these make the detection of outliers challenging. In this paper, an online unsupervised deep machine learning (DML) algorithm for outlier detection for time series with seasonality and trend is proposed. The proposed algorithm utilizes a neural network based on a temporal convolution network (TCN) and an autoencoder (AE) to reconstruct a time series that captures the normal behavior of the input data and then the reconstruction errors between the input and reconstructed time series at the output of the TCN-AE network are used for outlier detection. To train the TCN-AE network to learn the normal behavior of the input time series, we propose a two-step training process to overcome the presence of outliers in the training data. In addition, a novel loss function specially designed to address the seasonality and trend effects of the time series is proposed. Furthermore, a pre-processing technique is used to combat the adverse trend effect which might cause false alarms in outlier detection. The performance of the proposed TCN-AE-based outlier detection algorithm is evaluated using synthetic time series, Yahoo Webscope dataset and real time series of KPIs of mobile cellular networks. The results show that the proposed TCN-AE-based outlier detection algorithm achieves better detection accuracy in terms of F-score than other DML-based algorithms such as long short-term memory (LSTM)-AE-based algorithm and the convolutional neural network (CNN) based algorithm.


The study assessed the level of adequacy of educational resources available for implementing the mandate of Office Technology and Management Programmes in government owned Polytechnics in the South Western States of Nigeria. Eighty Seven (87) members of academic staff in the Department of Office Technology and Management in government owned Polytechnics in the South Western States of Nigeria comprised the population of the study. Since the population of the study was small, no sample was drawn for the study. Four research questions were formulated while a structured questionnaire was used as instrument for data collection. Data collected were analysed through the use of mean scoring techniques. The result of data collected and analysed revealed that facilities such as classrooms, laboratories, furnished staff offices and textbooks/journals are fairly adequate while micrographics and electronic communication equipment are not adequately available for training secretaries/office managers. The study also revealed that financial resources are not adequate and this had affected facilities installed in terms of their numbers and their maintenances. On the other hand, the study revealed further that adequate personnel are available but members of academic staff who are Information and Communication Technology (ICT) compliant are few. Finally, the study recommended among others, that government, Polytechnics management and other stake holders should establish a Resource Mobilization Centre that would be responsible for sourcing funds to purchase and install modern educational resources that will ensure effective teaching and learning processes and realization of the objective behind the introduction of Office Technology and Management programmes in Nigerian Polytechnics.


A new NASA interplanetary flight project, called Jupiter Orbiter Probe (JOP), has been recently approved by Congress. JOP involves a dual mission intended to explore the planet Jupiter and its environment with an atmospheric probe and a planetary orbiter spacecraft. The probe and orbiter vehicles are to be launched in tandem as a single spacecraft during the time from December 1981 to January 1982. The spacecraft will arrive at Jupiter at the earliest on November 14, 1984. Navigating the JOP spacecraft will be a critical task for the JOP mission. Attention is given to aspects of probe and orbiter delivery, Jupiter orbit insertion and perijove raise, the Satellite Tour, navigation development and the navigation system, the probe delivery, example orbits, velocity perturbation and correction, orbit determination characteristics, orbit determination and control profile, and the correction velocity requirements.


Abstract. We present a study of the temporal evolution of the chromospherically sensitive lines in the transiting exoplanetary system HD 189733 using high-resolution UVES spectra. With its fast temporal cadence of only 45 s and its wide spectral coverage, our time series is ideal to study the influence of the transiting planetary disk on chromospheric lines. We measured the equivalent width and central line depression of the Ca II H and K lines, Hα, and the Ca II infrared triplet. While all these lines show temporal evolution on a scale potentially induced by the occulting planetary disk, strong intrinsic stellar variability prevents us from uniquely ascribing the observed variation to the planetary transit.


The surface treatment method, a semiconductor device and a method are provided. Method of forming the semiconductor device includes forming a first oxide and a second oxide film on a substrate. A contact hole that exposes the substrate by patterning the first oxide and the second oxide film is formed. By reacting the HF with the first oxide sidewalls exposed by the contact hole is formed in a film a first reaction, reacting the first NH Wherein said film is removed first reaction and the second reaction film that the contact hole extends. Body contact is formed in the extended contact hole. Chemical oxide removal, the contact


Concurrent programs are more complex and error prone than their sequential peers, and are much harder to debug as well. High level data races (HLDR) are one of the concurrency bugs most difficult to debug. They are a class of concurrency errors that are not commonly addressed by the testing and debugging techniques and tools. HLDR result from the misdefinition of the scope of an atomic block, which should be unique but was wrongly split into two or more independent atomic blocks. Interleavings involving these misdefined atomic blocks may violate the program correctness invariants and cause the concurrent program to fail. In this work we propose a hardware module to detect, expose and tolerate HLDR in concurrent programs, with applications in both the software testing and debugging and the software deployment phases. In the detecting mode, our proposal detects HLDR with few false positives and without the overhead and intrusion of other dynamic software approaches. In the exposing mode, it "stimulates" the program to expose existing latent HLDR and trigger hidden HLDRs. Finally, in the tolerating mode, it may act as a software healing technique by inhibiting certain buggy interleavings. The results shows a reasonable performance overhead and few false positives in all modes.


In Japan there has not been much discussion about employers' obligation to disclose information, with the exception of the obligation to elucidate working conditions. The disclosure of information has always been unilateral; employers request information, and employees comply by producing it. The conventional wisdom in Japan is that the mutual possession of personal information makes for better personal relationships at the workplace. But in this case, it is the employee who is disclosing the information. Furthermore, the view that employers should be required to disclose information to their employees is a minority one. In actuality, corporations possess an enormous amount of information about their employees. However, when employees ask employers to disclose information, the latter are reluctant to cooperate, claiming that the information in question is company-confidential or citing their discretionary authority to deny such requests. There is no system in place that enables prospective employees to obtain detailed information about their prospective employers during the recruiting stage. Employees have no means for acquiring information about corporations that will aid them in selecting a company. Since employees rarely lodge complaints with public entities or institute litigation, no depository of such information has been created. On the rare occasions when a dispute reaches the courts, information about it is available, since major litigation is a matter of public record. Otherwise, one must rely on whatever information the corporation in question has provided to the media (including the Internet), which may be self-serving. The Labour Standards Law requires employers to elucidate working conditions, but does not require them to disclose information of other types. In actuality, employers possess a great deal of information about their employees, but they seldom disclose such information voluntarily. Employers explain or report on management problems on a regular basis or when necessary, and occasionally consult their employees on such matters. Like the establishment of labor-management consultative organizations, such consultations are voluntary. Since employer engages in them voluntarily, the disclosed information is limited in quantity and quality. Employees generally do not request the disclosure of information about substances that are harmful to the human body. Despite the fact that such information should be of vital interest to them, they leave such matters to the discretion of their employers. This phenomenon might be construed as a sign that a bond of trust has been forged between employers and employees. But it also indicates that employees do not show sufficient concern for their health. It is unlikely that employers are informing employers in advance about plans to monitor computer activity. Good employee-management relations are fostered when employers are forthright about personal information pertaining to employees in their possession. Today petitions relating to discriminatory practices are making their way to Japan's courts, where petitioners demand that personnel documents be produced. The courts tend to grant orders to produce such documents, as long as they were originally meant to be made public or submitted to external entities. The conventional wisdom is that employers should have discretionary authority over the disclosure of personnel evaluations. However, with the recent introduction of the merit-based wage system at Japanese companies, there is widespread agreement across all segments of society that not only the evaluation results, but the process by which they were arrived at should be disclosed. In the past, employees were always the recipients of requests for the disclosure of information. Currently, however, the debate centers on how such information should be protected. Still, it would seem that for labor and management to be on an equal footing, employers should be obliged to disclose information to the same extent as employees. In this article, I discuss the disclosure of information in Japan as it relates to working conditions business and financial plans, toxic or hazardous substances, the monitoring of employees' computer use, and personnel records.


In this paper, we propose a new signature scheme based on factoring and discrete logarithm. This scheme is based on two hard problems and provides higher level security as compare to a single hard problem. Most of the designated signature schemes are based on a single hard problem. Although these schemes secure but in a future if an enemy manages to solve this problem, are then he can recover all secret information including secret keys and parameters of the scheme. Our scheme is protected from such four attacks which are most common attacks for signature schemes.


[Objective]To study the efect of combination of Buyang Huanwu Decoction( BHD) and aspirin or supplementary therapy on platelet aggregation rate.[Methods] Patients received aspirin 395 cases,according to the rate of platelet aggregation of aspirin resistance patients screened in chronological order into two groups. Combined treatment group BHD + aspirin;BHD group with BHD,a course of 1 month.Examination before treatment and 1 month after treatment of platelet aggregation.[Results]395 cases of patients with aspirin resistance exists in 80 cases,accounting for 20.3%.Combined treatment group and BHD group 1 month after taking the platelet aggregation rate was 55.24% ±5.9%,60.4% ±7.9%,higher than before treatment were significandy decreased (P0.05).[Conclusion] BHD can reduce the rate of platelet aggregation in patients for aspirin resistance,use BYHWD with aspirin therapy to obtain a certain effect.


Hypothesis / aims of study It was hypothesised that a valve placed at the bladder neck would allow urine containment in the bladder, and that valsalva straining could serve to initiate flow through the valve for voiding, with containment returning once flow has ceased. Proof of this hypothesis required development of a device designed for restoring continence to post-prostecomy patients suffering from stress urinary incontinence. Vysera Biomedical has developed novel biomaterials that can mimic the mechanical properties of soft biological tissues and are demonstrated biocompatible, biostable in urine, resistant to encrustation and can be sterilised easily. A trifoliate valve design was developed, the function of which is to remain closed during bladder filling cycles and during short duration pressure spikes (e.g. cough), and to open automatically when a more sustained pressure increase (strain) is applied. The valve which traverses the bladder neck is opened by the application of abdominal strain and closes again automatically once flow has ceased. Operation of this valve has been previously verified by attaching it to the end of an indwelling catheter on the premise that bladder pressure is transferred hydrostatically through the catheter lumen and directly onto the valve thus mimicking the pressures the valve would encounter in-vivo [1]. In tandem, urodynamics and more specifically urethral pressure profilometry was used to assess the magnitude and temporal variation of pressures generated within the bladder and urethra during normal everyday activities and during straining and cough episodes. This information was essential in order to select the valve performance required to address this specific clinical need. Coupled to the valve, a shapememory scaffold was designed to contour to the relevant anatomical location where the valve needs to be deployed. The scaffold also has the function of preventing proximal and distal displacement of the valve and also of acting as a frame which prevents deformation of the valve in-vivo thus maintaining valve function even with typical anatomical variations. The valve-scaffold device is deployed at the bladder neck using a 21F custom catheter delivery using endoscopic and fluoroscopic guidance. The device can be sheathed using a custom 23F catheter and removed under local anaesthetic. Design of the scaffold, catheter systems and insertion/removal were informed by several cadaver studies. The aims of this phase 1 human study were to confirm safe insertion and removal of the device, to assess device tolerability in short-term use and to verify urine containment in the bladder under a range of conditions.


In this paper,the "Nakai" fitting test of tilt tide and the analysis of tidal tilt are used to process tidal deformation data.The tidal deformation observation data of Taian seismic station which is before the ML4.6 earthquake in the junction of Puyang and Xinxian on April 9,2006 are processed and analyzed.The result shows that in about 10 days before the earthquake,some short-impending anomalies are recorded at the Taian seismic station,which may be earthquake precursor information.


Radiation effects in InGaP, InGaAsP, and InGaAs solar cells were measured and analyzed using displacement damage dose approach by means of different energies of proton irradiation. Different In-P composition and proton energy depended degradation effects on the InGaP, InGaAsP, and InGaAs solar cell were investigated. The radiation-resistance increased with an increased in the fraction of In-P bonds in InGaP, InGaAsP, and InGaAs solar cells. It was found that the degradation of spectral response in the region of longer wavelength (red) for lower proton fluence and an anomalous spectral response in the region of shorter wavelength (blue) for higher proton fluence were observed. The damage coefficient K/sub L/ for the proton-irradiated InGaP, InGaAsP, and InGaAs was determined from the spectral response data and compared with that of InP.


A 320-keV spectrometer based on an 8-pixel transition edge sensor (TES) has been developed. It involves a unique 7-μm thick membrane consisting of silicon dioxide (SiO2), silicon nitride (SixNy), and SiO2. This membrane supports a 0.8-mm thick Sn absorber with suitable stopping power for photon energy <italic>E</italic> = 320 keV and is applicable up to <italic>E</italic> <inline-formula><tex-math notation="LaTeX">$ \approx $</tex-math></inline-formula> 0.7 MeV. Our trilayer membrane exhibits the same thermal conductance as conventional 1-μm thick SixNy one, i.e., <italic>G</italic> <inline-formula><tex-math notation="LaTeX">$ \approx $</tex-math></inline-formula> 1.2 nW/K at the critical temperature of 115 mK. We carry out the spectroscopy using a 51Cr radiation source and simultaneously read out the 8 pixels with a microwave SQUID multiplexer. We find a linear broadening trend between the pulse peak and pulse area, even after a correction of the baseline drift due to time-varied temperature of our cryocooler. Based on the relationship, we analyze the data and succeed in avoiding degradation of the energy resolution in spectra. The resultant full-width-half-maximum (FWHM) energy resolution Δ<italic>E</italic>FWHM of the measured 6 pixels satisfies Δ<italic>E</italic>FWHM<1.6Δ<italic>E</italic>NEP where Δ<italic>E</italic>NEP is the noise-equivalent-power energy resolution. The best energy resolution among them is Δ<italic>E</italic>FWHM = 159 eV at 320 keV. This is 5 times as high as that of high-purity germanium detectors at 77 K and the best resolving power for gamma-ray TESs operated at <italic>E</italic>>220 keV to our knowledge.


Almost all a student needs to know about Article 9 of the UCC. The book covers secured transactions from A to Z with examples and answers that will enable a student to test his knowledge and find the answers to the many conundrums in Article 9.


Aquaculturists rely heavily on the brine shrimp (Artemia salina) as a food source for fish larvae, decapods and cephalopods. Besides the difficulty in obtaining these cysts, they are costly. This study was designed to determine if an A. salina diet supplemented with macro algae and various scrap foods could obtain the same or better growth rate on juvenile lobsters than live A. salina fed as a single source diet.

The hepatopancreas of the lobster has been used as a criterion for determining the animal's general health. During this study, gross morphological examinations were made of the hepatopancreas of animals fed on both diets. This was done in order to determine if the characteristic color, size and firmness of the A. salina fed juveniles' hepatopancreases were accurate indicators of a "healthy" animal or characteristic of only the diet. After 90 days, the animals on the supplemented diet showed a significantly greater weight gain and increase in carapace length than the animals fed only A. salina. The hepatopancreas varied in color in the animals on the different feeding regimes. Though the size and firmness may be important criteria, the color cannot be used as a true indicator for a "healthy" animal.

The results of this study show that a supplemented diet can be an important economical factor in the application of practical aquaculture.


Conservation Paleobiology (CPB) has many aims, but ultimately depends upon our uncovering, for a target region, the history of environmental pressures and history of biological change, particularly biological change that signifies a response to anthropogenic stress: this is how we detect and correctly attribute deterioration, how we design and evaluate recovery, and how we ultimately assess resilience and sustainability. The focus of concern might be a single taxon of economic or other particular value, or larger-scale changes in biomass, taxonomic or phylogenetic diversity, or trophic complexity. One of the biggest challenges for natural scientists can be building the requisite history of cultural stressors – i.e., uncovering the diverse economic, industrial, social, and regulatory activities that might have affected the system. Such information is commonly not accessible via the Web of Science; it can be extremely important but qualitative or can be quantitative but highly variable in units or methods of measurement; and, with the exception of data on commercial harvesting (e.g., fishing, logging) and human population size, useful time-series are scarce. The CPB scientist thus typically needs to compile their own, original history of human activities having potential to affect natural systems, either to evaluate the (paleo)biological data that they already have on hand (from biomonitoring, live-dead analysis, sedimentary cores) or to frame a new campaign of data collection. Here, I describe approaches to finding and merging cultural data that have worked both for research and for class projects, using two coastal marine examples: (1) testing the effects of historical over-fishing (meta-analyses from the early 2000s), and (2) the unexpected role of land-use in the collapse of the open-shelf benthic ecosystem of southern California.


Summary FLOWERING LOCUS T (FT), a florigen in Arabidopsis, plays critical roles in floral transition. Among 13 FT‐like members in rice, OsFTL2 (Hd3a) and OsFTL3 (RFT1), two rice homologues of FT, have been well characterized to act as florigens to induce flowering under short‐day (SD) and long‐day (LD) conditions, respectively, but the functions of other rice FT‐like members remain largely unclear. Here, we show that OsFTL12 plays an antagonistic function against Hd3a and RFT1 to modulate the heading date and plant architecture in rice. Unlike Hd3a and RFT1, OsFTL12 is not regulated by daylength and highly expressed in both SD and LD conditions, and delays the heading date under either SD or LD conditions. We further demonstrate that OsFTL12 interacts with GF14b and OsFD1, two key components of the florigen activation complex (FAC), to form the florigen repression complex (FRC) by competing with Hd3a for binding GF14b. Notably, OsFTL12‐FRC can bind to the promoters of the floral identity genes OsMADS14 and OsMADS15 and suppress their expression. The osmads14 osmads15 double mutants could not develop panicles and showed erect leaves. Taken together, our results reveal that different FT‐like members can fine‐tune heading date and plant architecture by regulating the balance of FAC and FRC in rice.


The results of a large ensemble of regional climate models lead to two contrasting but plausible scenarios for the precipitation change over West Africa, one where mean precipitation is projected to decrease significantly over the Gulf of Guinea in spring and the Sahel in summer, and the other where summer precipitation over both regions is projected to increase. Dry and wet models show similar patterns of the dynamic and thermodynamic terms of the moisture budget, although their magnitudes are larger in the dry models. The largest discrepancies are found in the strength of the land-atmosphere coupling, with dry models showing a marked decrease in soil moisture and evapotranspiration. Some changes in precipitation characteristics are consistent for both sets of models. In particular, precipitation frequency is projected to decrease in spring over the Gulf of Guinea and in summer over the Sahel, but precipitation is projected to become more intense.


The X-ray structures of a high temperature α-phase (monoclinic, P2 1 /c, Z = 24) and a low temperature β-phase (orthorhombic, Pbca, Z = 8) of trichlorophosphazo-N-sulfurylchloride Cl 3 PNSO 2 Cl were determined at 173 K and 150 K, respectively. Both modifications are composed of isolated molecules arranged in layers with no strong intermolecular interactions with numerous Cl... O intermolecular interactions. The molecules in both modifications are fairly eclipsed along the P... S direction, the largest deviation from an ideal position being -17.4(2)° and 22.7(3)°. The bond lengths and angles of all molecules are equal within 4σ limits with an exception of P-Cl bonds.


New Zealand state housing includes a significant portion of problematic buildings constructed after the public housing scheme launched in 1936. Most of these houses are still uninsulated, thus, cold, draughty, mouldy, and progressively decaying; however, as they are fundamental elements of the country's culture, society, and environment, and are built with good quality materials and sound construction, they are suitable candidates for effective energy upgrades. This paper presents findings of a study on problems and opportunities of retrofitting the state houses built between 1940 and 1960 in the Auckland region. It advocates strategic national policies and initiatives for retrofitting, based on more challenging performance thresholds. The research defines and virtually implements an incremental intervention strategy including different retrofit packages for a typical 1950s stand-alone house. Indoor and outdoor environmental parameters were monitored over a year, and data used to establish a base case for thermal simulation. The upgrade packages were then modelled to assess their impact on the house's thermal performance, comparing heating requirements and comfort of various insulation and ventilation options. The paper reports on effective ways of preserving the integrity of such a house, while improving its thermal performance to the EnerPHit standard, and discusses the benefits of introducing this holistic approach into New Zealand retrofit practice.


The Psychomachia of the fifth-century Latin poet Prudentius provides a straight-forward portrait of heresy generally shared in the west: The wolf, with gory jaws, conceals himself in a soft fleece, Counterfeiting milk-white sheep while carrying on bloody murders by devouring lambs.It is by this means that Photinus and Arrius disguise themselves, those wolves so wild and savage.


Abstract Two experiments were conducted to determine the influence of NH 3 treatment on the aerobic stability of distillers wet grains and value of the NH 3 -treated grains as protein supplements for lactating cows. In Experiment 1, fresh distillers wet grains were treated with NH 3 at 0, 1.57, 3.14, or 4.71% of DM, compacted in polyethylene bags, and kept in aerobic storage at 16, 27, or 38°C for 14 d. Intermediate and high NH 3 reduced temperature increases, mold growth, and spoilage and improved DM recoveries. Low ammonia grains were less stable and deteriorated faster than untreated grains. In Experiment 2, lactating Holstein cows were supplemented with NH 3 -treated distillers wet grains (13.8% of total DM) or soybean meal (10.1% of total DM) for 70 d. Intakes of DM tended to be lower on ammoniated grains (19.4 and 17.6 kg/d). Milk yields (27.1 vs. 27.9 kg/d) and composition were not significantly different among treatments, but efficiency of converting feed to milk and income over feed costs were greater for ammoniated grains than soybean meal.


Plant samples were dissolved with HNO3 and H2O2 respectively in grinding conical flask placed directly on an ordinary flat aluminum electrothermal plate with an air-cooled tube.The reflux devices,consisting of 45 conical flasks can be heated simultaneously.This method keeps the sample solution under slight boiling conditions to digest the sample completely rendering the critical digestion time unnecessary.The 46 kinds of element contents in samples were determined simultaneously by Inductively Coupled Plasma-Mass Spectrometry(ICP-MS).The standard reference materials for the plants(GBW 10012,GBW 10014 and GBW 10019)were analyzed and the results were in good agreement with the certified values.The relative standard deviations(n=6) ranged from 0.44% to 5.59%.Compared to the methods of microwave digestion and dry ashing,this method is simple,rapid,uses less reagents and has lower blank and salinity which make it convenient for multi-elements measurements of plant sample by ICP-MS.The operating conditions of the ICP-MS were optimized by using debugging hydraulics,and the interference relationship was studied.The interference of determination was eliminated effectively by using a mathematical model.


The method of capturing a signal in a base station receiving at least (2a-2e) the wireless terminal (7) of the modulation signal transmitted to the present invention relates. In the wireless terminal (7), using the timing information (RTD, RTT) signal at least two different base stations (2a-2e) to capture the signal from the base station (2a-2e) at least one base station. The present invention is also the process system (1) and a wireless terminal (7) relates to the application.


Ensuring resilience of critical infrastructure systems when facing disruptions is of great importance to engineers, stakeholders, and decision makers. Providing an optimal strategy for strengthening infrastructure system performance before disruption and rapidly recovering systems after disruption are two visible approaches to enhance system resilience efficiently. However, because of the complexity of the interrelationship among system infrastructures and the budgetary limitation, there is an imperative requirement for a rigorous decision-making process to track the costs induced by any enhancement to the system. To address this issue, in this paper, a multiobjective and two-stage stochastic programming model was developed for minimizing network-level cost and mean risk by considering both pre- and post-event maintenance actions. To account for the effects of different improvement strategies on network resilience, this model was tested under various disruption scenarios that highlighted the hazard uncertainty by combining a variety of occurrence probabilities. In this model, pre-event activities represent bridge retrofit that could contribute to increasing robustness and redundancy of the network system, whereas post-event activities are bridge repair and recovery on the basis of the resilience-enhancing effects advanced by the pre-event actions. The consequential optimization is the optimal social-economic outcome that considers different construction and disruption scenarios, and indirect costs associated with the system.


Covid‐19 Variants and Prevention Preventive strategies such as vaccines, repurposed drugs and physical‐materials science based scenarios to create vectors interacting with SARS‐CoV‐2 to tackle the spread of the virus and its various mutations have been an exceptional addition to humanity's arsenal to cope with the ongoing Covid‐19 pandemic. More details can be found in article number 2104495 by Mohan Edirisinghe and co‐workers.


The tittle of this study is the Stress Reaction of Main Character in the Short Story Maafkan Mama by Glory Gracia Christabelle. The issues describes the stress reaction of the main character. This study aims to describe the stress reaction of the main character on negative reaction: the psychological reaction, physiological reaction, the cognitive reaction and behavioral reaction. The method used in this study is descriptive analytical method. The data source of this study is the Short Story Maafkan Mama by Glory Gracia Christabelle, a collection of short stories entitles Girl, published by Sarana Bobo Publishing. The data is analyzed by using qualitative analysis techniques. Results of this study indicates the negative stress reaction of the main character: phychological reaction, physiological reaction, the cognitive and behavioral reactions. The stress reaction of the main character illustrates the impact that can occur to children when they are required to learn beyond the capacity of their ability.


We contribute to the field of Information Systems by attempting to develop a first innovative social networking application, the "SignaComm". The SignaComm's objective is to enable multilingual communication between users worldwide for the protection of personal data on the Web. We design this application while relying on the theory of patterns as well as the principles of ontologies and signage system. The theory of patterns presents good practices for creating a model, which describes the characteristics of a generic solution to a specific problem. It permits the reuse and remodelling of patterns to serve as resources for software development and problem solving. Ontologies describe a structured set of concepts and objects by giving a meaning to an information system in a specific area, and allow the construction of relationships between these concepts and objects. The signage system is a visual communication system with an international vocation where, the "signagram" is the writing unit. When creating the SignaComm we use an automatic translation software of key-phrases into signagrams. The social networking application is written with the Python, PHP and Javascript programming languages and then tested technically. We hope that users from any culture, social environment or with disabilities could use it.


Several recent studies have documented the fact that, in considering feedback, learners are actively making credibility judgements about the feedback and its source. Yet few have intentionally explored such judgements to gain a deeper understanding of how the process works or how these judgements might interact to influence engagement with and interpretation of feedback. Using the educational alliance framework, we sought to elaborate an understanding of learners' credibility judgements and their consequences.


ABSTRACT Peanut (Arachis hypogea L.) is an important crop in the Virginia-Carolina (VC) region, but cool and wet falls may result in significant yield reductions due to Sclerotinia blight, caused by Sclerotinia minor (Jagger), a major disease in the region. Transgenic lines expressing a barley oxalate oxidase were previously shown to confer improved resistance to the disease. This research compared three blight resistant transgenic lines for oxalate oxidase, N70, P39, and W73 with their non-transgenic parents, NC 7, Perry, and Wilson, and high yielding check cultivars Bailey and CHAMPS. The objective was to ensure that the agronomic and physiological characteristics of the transformed lines were not negatively impacted by the transformation with oxalate oxidase before making recommendations for production. In 2009 and 2010, experimental plots were grown in two distinct fields for soil type and available water capacity for a total of four environments. The transgenic lines were statistically comparable wit...


The methods of radar target tracking have a substantial effect on the accuracy of the whole radar systems. The basic principles and implementing steps of the Extended Kalman filter (the EKF) and the Unscented Kalman filter (the UKF) are briefly introduced. The main sources of radar observation errors and the limitation of the current methods are analyzed. According to the requirements of tracking a CV target, the EKF and the UKF are used to simulate the experiments by establishing the specific model of radar target tracking. The results show that the tracking errors can be constrained within a certain range and the whole systems also have the high tracking accuracy.


How was the Bush administration able to convince both Congress and the American public to support the plan to go to war against Iraq in spite of poorly supported claims about the danger Saddam Hussein posed? Conventional wisdom holds that, because neither party voiced strong opposition, the press in turn failed to adequately scrutinize the administration's arguments, and public opinion passively followed. Drawing on the most comprehensive survey of public reactions to the war, Stanley Feldman, Leonie Huddy, and George E. Marcus revisit this critical period and come back with a different story. Not only did the Bush administration's carefully orchestrated campaign fail to raise Republican support for the war, opposition by Democrats and political independents actually increased with exposure to the news. But how we get our news matters: People who read the newspaper were more likely to engage critically with what was coming out of Washington, especially when exposed to the sort of high-quality investigative journalism still being written at traditional newspapers-and in short supply across other forms of media. Making a case for the crucial role of a press that lives up to the best norms and practices of print journalism, the book lays bare what is at stake for the functioning of democracy-especially in times of crisis-as newspapers increasingly become an endangered species.


Field ion microscopy was applied for uniaxial tension tests at cryogenic temperature.The plastic deformation of near damage-free submicron-sized metallic glass wires was found to remain shear band operation even the diameter was less than 200 nm.The critical sample dimension for inhomogeneous-to-homogeneous transition may be overestimated before.


An active addressing flat panel display is provided to prevent damage of an electrode part caused due to external impact and external pressure by regularly maintaining a gap between a sealing member and a second electrode part. An active addressing flat panel display includes a substrate(1), a light-emitting part(P), a non-light-emitting part, a sealing member(121), and a spacer(3). The light-emitting part(P) is formed on an upper surface of the substrate(1) and is driven by a TFT(Thin Film Transistor). The light-emitting part(P) includes a first electrode part(41), an organic layer(42), and a second electrode part(43). The non-light-emitting part is formed on the upper surface of the substrate. The sealing member(121) is arranged in a predetermined position opposite to the substrate(1) in order to seal the light-emitting part and the non-light-emitting part. A spacer(3) is inserted between the light-emitting part and the non-light-emitting part.


OBJECTIVE: To study the effect of siRNA on VEGF-165 expression in vitro on cultured SiHa cells.METHODS: The specific siRNA was transfected into VEGF overexpressed cervical neoplasms cell SiHa lines in vitro by Hiperfect transfection reagent.The VEGF-mRNA level was detected by real time RT-PCR after the transfection with siRNA.The effect of RNA interference was observed at 12,24,48 and 72 hours.The secretion of VEGF protein in the supernatant was evaluated by ELISA.The cell proliferation was tested by MTT assay.RESULTS: Sequence specific siRNAs of VEGF-165 effectively downregulated the mRNA levels of VEGF compared with the controls(F were 99.94,169.27,460.90 and 115.86,P0.05).The protein levels were down regulated obviously post transfection(F were 107.06,136.46,147.10 and 54.25,P0.05).The growth of SiHa cells was obviously inhibited(F were 70.58,61.17,113.39 and 100.94,P0.05).The cells in control groups had not obviously changed,P0.05.CONCLUSIONS: Specific siRNA can effectively downregulate the expressions of VEGF mRNA and its protein,and inhibit the cell growth.The study makes the therapeutic approach with gene therapy more possible in cervical neoplasms.


Mechanochemical activation of solid inorganic precursors and sol-gel routes followed by hydrothermal treatment in the presence of surfactants were used to synthesize highly dispersed NZP-type complex zirconium phosphates. Genesis of samples real structure and its impact on the surface properties and catalytic performance in the reactions of hexane isomerization and dehydroaromatization have been studied.


Prostate cancer (PC) is the malignancy with the highest incidence worldwide in males. Although localized disease can be effectively treated and usually has a favorable prognosis, progression to metastasis results in high mortality rates as current treatment modalities are not yet curative. The standard of care for advanced PC is hormonal therapy, termed Androgen Deprivation Therapy (ADT). Unfortunately, ADT typically elicits the emergence of a lethal phenotype, termed Castration-Resistant Prostate Cancer (CRPC), which is treatment-resistant and frequently gives rise to a highly aggressive variant with features of neuroendocrine (NE) differentiation, known as Neuroendocrine PC (NEPC). There is no cure for NEPC, thus identifying drivers that lead to its emergence is of paramount importance. We used the Sleeping Beauty (SB) transposon system to perform a forward genetic screening on Genetically-Engineered Mouse Models (GEMMs) of CRPC that are known to develop NEPC under ADT pressure. SB transposon activation generated tumors with an accelerated growth phenotype and increased metastasis incidence compared to non-activated controls. Notably, several tumors presented histological features of NEPC. We sequenced SB transposon integration sites on tumors' genomes to identify recurrent patterns suggesting genes responsible for phenotype acceleration and NEPC differentiation. Recently, we generated and assembled a set of >100 GEMM-derived tumors, that recapitulate a broad spectrum of PC disease states, to reverse-engineer a network of regulatory proteins. We used this network on RNA-Seq data collected from SB-activated tumors to identify Master Regulator (MR) proteins that are specifically associated with NEPC emergence. Cross-species network analysis of patient-specific MRs activity conservation between patient and our mouse cohorts, aligned NEPC patients to mice tumors with NE features, corroborating our study's clinical relevance. We performed an integrative network analysis that links genomic events as generated by SB transposon integrations to downstream regulatory programs implemented by MR proteins. This analysis prioritized Sirt1 as upstream modulator of NEPC MRs activity. Activation of SIRT1 in human adenocarcinoma PC cells induced NE-like phenotype, while SIRT1 inhibitor in NEPC cells reduced tumor aggressiveness. In summary, we used in vivo models of prostate cancer to elucidate molecular drivers of NEPC, a lethal variant that is treatment-resistant. Integrative network data analysis prioritized Sirt1 as driver of NEPC emergence and was validated in vivo.
 Citation Format: Alessandro Vasciaveo, Francisca Nunes De Almeida, Min Zou, Matteo Di Bernardo, Andrea Califano, Cory Abate-Shen. Identifying neuroendocrine prostate cancer drivers using in vivo forward genetics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1116.


Previously we reported the outcome of 50 patients treated with an induction ThaDD regimen followed by a randomized maintenance therapy with a-Interferon or thalidomide and low-dose dexamethasone. At present, 88 patients with newly diagnosed MM have been enrolled in the ThaDD protocol. Here we present the updated results of the first 50 enrolled patients after a 42 months median follow-up (range 27–60). Baseline characteristics of the 50 patients were previously reported. Briefly, median age 72 years (range 65–78; 14% ≥ 75 years), more than three quarter of patients scored ISS 2–3, 60% presented abnormal serum levels of C-reactive protein (sC-RP) and 24% had unfavourable cytogenetics. Post-randomization best response included 34% CR, 14% nCR, 14% VGPR, 28% PR and 6% MR. One patient was diagnosed with progressive disease and two (4%) died early before response assessment. Median and 3-years TTP was 32 months and 40%, respectively. Median and 3-years PPF was 24 months and 38%, respectively. Factors negatively affecting PFS in univariate analysis were age > 70 years (p=0.054), abnormal sC-RP level (p=0.023), randomization to Interferon (p=0.046) and response to induction grade 2 thrombocytopenia. Only 2 patients dropped out due to toxicity (1 EP, 1 severe infection). During thalidomide maintenance severe peripheral neuropathy was observed in 2 patients and 2 other patients died for myocardial infarction. In conclusion, patients treated with ThaDD showed similar TTP, PFS, OS and non-hematological toxicity but less hematological toxicity and better compliance compared to that reported in patients treated with MPT (Palumbo et al, Blood 2008; Facon et al, Lancet 2006) or VMP (Mateos et al, Haematologica 2008; San Miguel et al, EHA 2008). Patients with normal sC-RP level and achieving at least VGPR after ThaDD gained a very long PFS. However, even patients with abnormal sC-RP level or who didn't achieve VGPR could have a long-term PFS if transplanted or maintained with thalidomide after induction, respectively. Outcome of salvage therapy with bortezomib, dexamethasone and chemotherapy seems to be not affected by time on thalidomide treatment.


To the Editor: There are several reports describing apparent bacterial stimulation of anti-K production. Marsh et al.' reported production of the antibody in a 20-day-old child who had acute enterocolitis caused by Escherichia coli 0125:BlS. Possible relationships between infection with Mycobucteriwn tuberculo&J and Morganella morganii' and the production of anti-K have been documented. McGinnis et al.5 showed that, while no Klike antigenic structure was demonstrable on intact type D streptococci, such a structure was detectable in a suspension of disrupted organisms. Savalonis et al.6 tested a number of gram-negative bacteria for the presence of K-like antigens. Their only positive finding involved E. coli 0125:B15, subtype 12808, but the cases cited above strongly suggest that other bacteria are able to stimulate production of anti-K in man. We recently encountered a 30-year-old man who was admitted to our hospital with acute necrotizing pancreatitis secondary to alcohol abuse. The patient later became septic and developed adult respiratory distress syndrome and renal insufficiency. On the third hospital day, a blood culture showed the presence of Enterococcus fuecalis, and a culture of the femoral catheter tip grew Enterobucter cloacae. On that same day, the patient became febrile (39.4"C) and hypotensive (RR 80/25). The peripheral blood count showed 10.5 x lo9 white cells per L, and treatment with cephazoline, gentamicin, and metronidazole was started. The patient's blood type was group 0, Rhpositive, and on Day 3 the antibody screening test was negative. The patient was transfused with 2 units of red cells, retrospectively shown to be K, and 6 units of plasma that had been screened and shown not to contain atypical blood group antibodies. Two days later (hospital Day 5) , the antibody screening test was repeated when 2 additional units of blood were ordered. This time the test was positive and anti-K was identified by our local blood bank. The rapid production of anti-K by this patient, who did not receive K + red cells, appears to be related to his bacterial infections. Although it is impossible to be sure which, if either, of the organisms was responsible for the stimulation of antibody production, E. fuecalis appears a more likely candidate than E. cloacae, because the latter organism has been shown to lack a K-like structure. Studies are needed to show whether E. fueculis carries a K-like structure. C.J.A. DOELMAN, PHD W.F. WESTERMA", MD E. VAN VOORST TOT VOORST, MSc K. MIEDEMA, PHD Departments of Clinical Chemistry, Haematology, and Pulmonary Diseases Ziekenhuis De Weezenlanden Groot Wezenland 20 801 I JW Zolle The Netherlands


Editor—The article by Lenzer and the associated commentary by Saver et al raise many serious issues, among which is the residual state of uncertainty concerning the efficacy of alteplase (tPA) in acute ischaemic stroke.1 Confronted by opposing interpretations of the aggregate data published to date and the now known baseline imbalance in the severity of stroke in the National Institute of Neurological Diseases and Stroke (NINDS) trial, doctors are presented with a conundrum: what action do the data support?

The reported unwillingness of the investigators and sponsor of the National Institute of Neurological Diseases and Stroke trial to provide data for additional analysis is disturbing. Emanuel et al have described seven requirements for the ethical conduct of clinical research, among which is social and scientific value.2 Social value presupposes the public dissemination of research results. I have formulated a standard for the scientific and ethical review of trials that elaborates on this requirement.3

Implicit in this requirement is the necessity for the public dissemination of the complete dataset acquired during a clinical trial. This allows interested investigators to apply recognised analytic techniques in an attempt to resolve (or diminish) residual uncertainty concerning the clinical implications of the trial's results. This ethical requirement has not yet been met for the National Institute of Neurological Diseases and Stroke trial.


Here, Zelco et al. used single-cell RNA sequencing to generate the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes under normal conditions and after perinatal brain injury. They found that early after hypoxic–ischemic insult, neutrophil numbers increased and exhibited increased granulopoiesis, suggesting that the meninges are an important site of immune cell expansion with implications for the initiation of inflammatory cascades after neonatal brain injury.


Through the research of the transformation method based on PPRM expression,based on the synthesis time,a synthesis method based on the original algorithm abandon using large-scale reversible logic gates is presented.Experiments for some benchmark functions using new synthesis algorithm are made.The result shows that the new algorithm greatly improves the speed of synthesis and saves resources.


The first thing you notice when the educators and three and four year old children embark on their weekly walk is that the cold rainy weather just doesn't stop them. They all bundle up in jackets, hats, gloves and gumboots. This walk takes place at the Cornish Campus of St. Leonard's College in Bangholme, Victoria. The school is set on 80 hectares of natural bush setting which is home to a chook pen, orchards, a small farm, a lake, an island, a bird hide, wetlands and more.


We appreciate Hilborn (1) for reminding us that South and Southeast Asia are the regions where marine protected areas (MPAs) could improve fisheries catches. We fully agree, and in fact, our results indicate that many areas in these regions could benefit from MPAs (figure 1 of ref. 2). We want to clarify, however, that the figure referenced by Hilborn to argue that our results were not credible (figure S4 of ref. 2) shows a future scenario where all fisheries globally are well managed. In that scenario, it makes sense to place MPAs in areas away from the coastal zones to minimize trade-offs with fishing. Nonetheless, while only a small fraction of those regions were included as part of the top priority of a globally optimized MPA network, our global network (figure 2 of ref. 2) is just one solution out of several other network designs that could improve future fish catch. In practice, regions or countries may want to optimize local food benefits from MPAs. The globally optimized MPA network solution was driven by factors besides fisheries status such as the size and geographic extent of individual stocks. While it is known that a conservation action in one country can affect other countries (3), we recognize that our simplified assumption about adult fish and larvae movement could overestimate the geographic extent of spillover effects; indeed, this was the subject of a reply to our paper by Ovando et al. (4, 5). We note that we only considered a limited number of stocks for which species-level data are available. Many of the stocks in the South and Southeast Asian regions are either unreported or reported only under a broad category of "miscellaneous nei" (6). These unreported and "unassessed" stocks are on average in worse shape compared to those that are monitored or reported at the species level (7). As such, our results provide a conservative indication of catch-increasing MPAs in this region, a conclusion that we think accords with the thrust of Hilborn's reply. More granular data on unreported stocks, and incorporating more detailed models of spatial movement would likely give rise to larger areas in South and Southeast Asia where MPAs could improve catch. We note that we use the business-as-usual policy scenario of ref. 8 as a pessimistic benchmark of the future of global fisheries. Recent data showing reduced fishing pressure in some regions, particularly in developed countries, are a welcome development. As we highlighted in our paper, the magnitude of fisheries benefits from MPAs rests on how global fisheries will be managed in the future; our model shows that countries that reduce fishing pressure will see commensurate reductions in the optimal size of MPAs. For regions where fisheries reform is elusive, particularly in South and Southeast Asia, our paper shows that MPAs can help improve fish catch. It is worth noting that even in Europe [where many stocks are overfished (9)] and the United States, there are opportunities for significant yield-improving MPAs in some fisheries (e.g., see demonstrated improvements reported in refs. 10 and 11).


Pyrolysis oil produced from waste tires was decomposed in a reactor equipped by dc water/argon plasma torch. Atmosphere in the reactor was controlled by the adding of oxygen, carbon dioxide and water so that the overall amount of oxygen enables the entire gasification of oil. Synthesis gas with the high content of hydrogen and carbon monoxide and carbon black particles with the size of several hundreds of nm were produced.


The invention relates to a laser direct imaging system and a method. The laser direct imaging system includes a stage, a laser device and an oxygen-reducing device. The stage is subjected to an atmospheric pressure. The laser device is configured to provide a laser beam to scan across the substrate. The oxygen-reducing device operates simultaneously with the laser device for outputting an inert gas only to a specific area where the laser beam is being aimed such that any portion of the substrate, if enters the specific area, will be exposed to the laser beam under a low-oxygen environment.


This work of course completion aims to evaluate experimentally the fracture mechanics of
polymeric mortars with barley tailings as an aggregate. Samples of barley-reinforced polymeric
mortar were manufactured from 1% to 5% of beer residue, by mass, as an added substitute.
Then the resin ratio was set at 12%. All samples used a 4:1 ratio of base and hardener.
In order to analyze the effect of the inclusion of this aggregate on the fracture properties of
the mortar, test specimens were produced. A classic fracture proofing body is used in the
literature called Brazilian disc, widely used in materials such as concrete, which have low
tensile strength and high compressive strength, and are produced by the molding process, its
manufacture is given by the molding process, a more usual form of manufacturing with polymer
mortars. This method, precisely by the type of test specimen, is suitable because it
allows a variety of fracture loading combination of mode I and II to be applied by varying
only one parameter.


A case study in supply and demand - the violin scene history of violin frauds liability for misdescriptions - civil and criminal law business or pleasure - legal traps misdescriptions and false labels fakes and forgeries - the problem of attribution stolen violins improving violin trading and repairing standards a summary of practical guide-lines for everyone involved in the violin trade.


The searching algorithm of the doubly quasi-perfect binary array pairs is presented,which is based on the theory of the doubly quasi-perfect binary array pairs,using the transform properties.Finally some doubly quasi-perfect binary array pairs with small size are listed by computer searching.


Meat can be defined as "the muscle tissue of slaughter animals".1 It is one of the most important feeding source for humans because it has high amount valuable protein and important micronutrients essential to provide good health for people,2 briefly. Some studies are available on meat industry, but not so much. For example, Tarrant3 illustrate some of scientific search priority areas for the meat industry in product safety, product quality and product development.4 Meat industry was affected by technological developments. The technologies that have key importance for meat industry was shown in Figure 1.5 In a study carried out by Kristensen L et al.,5 from 1950s to today, important technological developments of meat industry was given in detailed. For this reason, it is not mentioned again in this study.


Blockchain technology has been developed for more than ten years and has become a trend in various industries. As the oil and gas industry is gradually shifting toward intelligence and digitalization, many large oil and gas companies were working on blockchain technology in the past two years because of it can significantly improve the management level, efficiency, and data security of the oil and gas Industry. This paper aims to let more people in the oil and gas industry understand the blockchain and lead more thinking about how to apply the blockchain technology. To the best of our knowledge, this is one of the earliest papers on the review of the blockchain system in the oil and gas industry. This paper first presents the relevant theories and core technologies of the blockchain, and then describes how the blockchain is applied to the oil & gas industry from four aspects: trading, management and decision making, supervision, and cyber security. Finally, the application status, the understanding level of the blockchain in the oil and gas industry, opportunities, challenges, and risks and development trends are analysed.


Objective To approach the clinical value of ultrasound-guided percutaneous transhepatic cholangiographic drainage(PTCD) in the treatment of malignant obstructive jaundice.Methods Twenty-five patients with malignant obstructive jaundice were treated with ultrasound-guided PTCD,and the therapeutic effect and complications were observed.Results All the patients were successfully punctured,and the successful rate of single puncture was 92.00%(23/25).Jaundice of all the patients decreased 3 to 6 days after PTCD.The serum total bilirubin and the inner diameter of intrahepatic ducts decreased after PTCD.The complications included bile exudation and slight bloody bile(either 1 patient).Conclusion Ultrasound-guided PTCD is a simple,safe and effective way to reduce jaundice,and can be regarded as the first choice in the treatment of malignant obstructive jaundice.


Introduction The Seychelles Archipelago comprises 115 islands in the western Indian Ocean, and form the northern most part of the Malagasy biogeographical subregion. The Seychelles can be broadly divided into the northern granitic and southern coral islands (Braithwaite 1984) (Fig. 1). The granitic islands are situated approximately 930 km NE and 1600 km E of Kenya and Madagascar respectively. The southernmost coral islands of Aldabra Atoll lie about 800 km SW of the granitic islands.


A g-C3N4 and n-Bu4N+Br− combination is used for the first time for the conversion of epoxides to cyclic carbonates under CO2 filled balloon conditions. This combination was found to be very efficient for the conversion of a wide number of epoxides.


The idea of fibre Bragg gratings (FBG) applied as a wavelength reference for microchip laser is considered. The elementary measurements and frequency stabilization set-up are presented


This article analyzes the loess properties and structural characteristics,on the basis of full grasp of the loess foundation pit construction points,a construction project in Shenzhen metro for concrete analysis object,summarizes the loess foundation pit construction of composite soil nailing support reconstruction measures and the suggestion,and provide some reference for the domestic other loess foundation pit construction.


ABSTRACT This article discusses the presence of "images" in the Afro-Brazilian religion Candomblé. In many traditional houses of Candomblé it is often said that it is not allowed to photograph or film rituals. On the other hand, in recent years, the presence of Catholic and other figurative images in Candomblé shrines has been questioned by recent "purification" movements—often led by these traditional houses—who fight syncretism, separating Catholicism from African religion. Still, in many cases figurative images are present in shrines, and rituals are photographed and filmed. This article argues that, beyond syncretism, images in Candomblé are contentious because they can be powerful: they can be indexes of the presence of Candomblé santos, they can become instances of a "distributed person."


A new long-period fiber grating structure based on a tapered fiber side contacted with a metal grating is proposed and demonstrated in this paper. The temperature/index tuning sensitivity can be enhanced, and the unusual spectral response of decreasing phase-matching wavelength with respect to increasing grating period and temperature is observed.


The large top quark mass suggests that the top plays a pivotal role in electroweak symmetry-breaking dynamics and, as a result, may have modified couplings to electroweak bosons. Hadron colliders can provide measurements of these couplings at the $\ensuremath{\sim}10%$ level, and one of the early expected triumphs of the International Linear Collider (ILC) is to reduce these uncertainties to the percent level. In this article, we propose the first direct measurement of the standard model $W\mathrm{\text{\ensuremath{-}}}t\mathrm{\text{\ensuremath{-}}}b$ coupling at the ILC, from measurements of $t\overline{t}$-like signals below the $t\overline{t}$ production threshold. We estimate that the ILC with $100\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ can measure a combination of the coupling and top width to high precision, and when combined with a direct measurement of the top width from the above-threshold scan, results in a model-independent measurement of the $W\mathrm{\text{\ensuremath{-}}}t\mathrm{\text{\ensuremath{-}}}b$ interaction of the order of $\ensuremath{\sim}3%$.


The article analyses the consequences of living in a country with a multidimensional crisis with serious psychosocial consequences (social suffering, predominance of negative emotions and their correlation in physical, psychological and social life, increase of uncertainty and anguish). In general loss of well-being and quality of life of all Venezuelans but specifically the university sector is analysed. Thus twenty two active and retired professors from public and private universities were interviewed, seven of them now live outside of Venezuela and gave their testimony on how the crisis has affected them and what have been their strategies for resistance. The purpose of examining this group is to give special attention to the university sector and to show the efforts and suffering of these heroes who, in spite of the crisis that hit hard the universities that oppose the political position of the government, continue to give the best of themselves regardless of the deterioration of their working conditions, personal finances and physical and emotional well-being. This work has three parts, the first reviews articles from the countries' leading scholars who are trying to define this period of crisis within its economic, political and social dimensions. The second part takes into account several researches carried out on the emotional environment and the impact of the crisis in Venezuelans and then analyses psychosocially the relationship between crisis and university professors. It is proposed a perspective of analysis that is committed with the fundamental premise of political psychology. The last part presents the conclusions.


Gigabit-capable passive optical network(GPON)is the basic technology to support the structure of the next-generation fiber to the home(FTTH) system.ITU-T has published 4 versions of GPON protocols(G.984.x).In this paper,based on the details of the 4 versions and the serial characters of G.982 and G983.x,the compatibility and other considerable issues of GPON application system ares presented.The paper also describes systematically the reference structure,transmission convergence and key techniques of GPON system,especially the transfer principle and frame structure of GPON.These are important references for designing and building GPON-FTTx.


We hardly regard politics--certainly not the words of politicians--as a realm where truth and honesty are closely protected. Public ignorance undoubtedly often pairs with politicians' disregard for accuracy to allow lies to pass. It is still galling, though, when political process and public reflection are stubbornly resistant to the obvious. It is more disturbing yet if the ignorance seems almost willing--a deeper kind of dishonesty in and with ourselves. By nature I am neither cynic, nor pessimist, nor one who disdains politics and public life because they can be infused with ignorance. In the last twenty-four months, moreover, I have been encouraged by the distance insurance reform has traveled, notwithstanding current efforts to repeal the most ideologically moderate of reform approaches. Nonetheless, I now find myself haunted by suspicions of a deep dishonesty in our culture. My original point of suspicion is the laudable requirement to admit patients to emergency rooms regardless of their ability to pay, but I can now add two related ones: the "insurance effect" fueling health care costs, and the mantra that prevention lowers costs (in particular, that reducing smoking will lower costs). Since enactment in 1985, the Emergency Medical Treatment and Active Labor Act has required hospitals to admit patients for emergency care regardless of ability to pay. (1) It now provides a historical and legal anchor for a fairness and efficiency argument to mandate insurance to achieve universal access. The argument begins with the fact, achieved by EMTALA, that the United States already has universal access to emergency care. Exemplifying the underlying moral principle of rescue, this law has wide, deep support: first passed with bipartisan support in 1985, reaffirmed in 1998, and not politically challenged in all the tumultuous debates of 2009-2010. If we agree that universal access to emergency care is a good thing, as we apparently do, then unfairness, free-riding, and inefficiency drive the argument to a mandate. Most of the cost of providing emergency care to those who cannot pay is shifted to people with insurance, who consequently pay higher premiums. These payers are not necessarily the parties from whom it is fair to extract the "tax" to fund this access. Moreover, the cost shift enables some to free-ride unfairly by escaping paying for insurance, knowing that emergency care will be available anyhow. In any case, emergency care often ends up substituting for primary and other care that is not accessible--a very inefficient substitution. In a context where universal access to emergency care is guaranteed but other basic care is not, the only feasible remedy for this unfairness and inefficiency is to mandate insurance for basic care more generally. (2) An oddity thus created for our current situation deserves notice: a key link in the argument for an insurance mandate, now being challenged as unconstitutional, is itself a federal law that's not been challenged. Also, notice how sly or shrewd a step EMTALA may have been, in historical hindsight, for the cause of universal access: put in place access to emergency care, then let the momentum and pressure from it roll all the way to a broader access. Pull that off, moreover, without complicating the political prospects of the initial step by owning up to how to pay for access to ERs. In retrospect it is not hard to understand why a society resistant to universal access (and to paying for it) might choose emergency care as one of its first major steps toward universal access. Not all that respectable, perhaps, but understandable: live up to the moral call of rescue by guaranteeing emergency care, but then dodge financial responsibility. (3) Here the mandate is easy to leave unfunded since an avenue of "backdoor" financing is available. Emergency care is provided by institutions (hospitals) that are large enough to absorb the immediate costs and shift them onto other payers. …


Abstract Compressed sensing allows recovery of image signals using a portion of data – a technique that has drastically revolutionized the field of through-the-wall radar imaging (TWRI). This technique can be accomplished through nonlinear methods, including convex programming and greedy iterative algorithms. However, such (nonlinear) methods increase the computational cost at the sensing and reconstruction stages, thus limiting the application of TWRI in delicate practical tasks (e.g. military operations and rescue missions) that demand fast response times. Motivated by this limitation, the current work introduces the use of a numerical optimization algorithm, called Limited Memory Broyden–Fletcher–Goldfarb–Shanno (LBFGS), to the TWRI framework to lower image reconstruction time. LBFGS, a well-known Quasi-Newton algorithm, has traditionally been applied to solve large scale optimization problems. Despite its potential applications, this algorithm has not been extensively applied in TWRI. Therefore, guided by LBFGS and using the Euclidean norm, we employed the regularized least square method to solve the cost function of the TWRI problem. Simulation results show that our method reduces the computational time by 87% relative to the classical method, even under situations of increased number of targets or large data volume. Moreover, the results show that the proposed method remains robust when applied to noisy environment.


W orldwide, approximately 26 million legal and 20 million illegal abortions are performed annually; this has resulted in an abortion rate of 35 per 1,000 women aged 15-44 years. Since the 1960s, surgical abortion by vacuum aspiration or dilatation and curettage has been a method for performing abortion. The use of the medical abortion by mifepristone in the 1980s has changed the aspect of traditional abortion performed. The use of medical abortion or mifepristnone has been increasing in countries where this product has been available. This review examines the historical issues and the use of medical regimen.


Pakistan Under Siege: Extremism, Society, and the State Madiha Afzal. Washington DC: Brookings Institution Press, 2018. $36.99. 192 pp. Fierce Enigmas: A History of the United States in South Asia Srinath Raghavan. New York: Basic Books, 2018. £30.00/$40.00. 486 pp. Emergency Chronicles: Indira Gandhi and Democracy's Turning Point Gyan Prakash. Princeton, NJ: Princeton University Press, 2019. £24.00/$29.95. 439 pp. Messengers of Hindu Nationalism: How the RSS Reshaped India Walter Andersen and Shridhar D. Damle. London: C. Hurst & Co., 2019. £25.00. 405 pp. Many Rivers, One Sea: Bangladesh and the Challenge of Islamist Militancy Joseph Allchin. London: C. Hurst & Co., 2019. £17.99. 237 pp.


The article tells us about didactic model of pupils'' teaching in primary national schools. The basis of such teaching is bilingual education. The author justifies practicability of teaching Mathematics on the basis of bilinguality as the factor of improving the guality of education.


In the light of that the old working process and managerial mode of the periodicals has no longer fit in with the requirements of the new times for the periodical work of university library, this paper puts forward some ideas of changing the traditional thinking mode, reforming the traditional working process and managerial mode of the periodicals, and increasing the utilization ration of the academic periodicals.


To understand smart technology as a material for design, we develop an articulation of both its materiality and material composition


The subjects researched the different raw material composition,different structure of the wool fabric for the impact of anti-static fabric.It tested the fabric of raw materials,density,tex,organization,square metres and tightness, and tested the anti-static performance of fabric after the friction static voltage size,voltage static attenuation size,to show the detecgted fabric with static electricity.From the organizations and the tightness of the performance,it analyzed its further concludes that general law of the organizational structure and anti-static fabric. It can provide some theoretical basis to produce the thin-and-light and comfortable fabric,to study the relationship between the fabric and its structure.


Unlike bacteria, many of which can be grown on an artificial nutrient medium, viruses require a living host cell for replication. Infected host cells (eukaryotic or prokaryotic) can be cultured and grown, and then the growth medium can be harvested as a source of virus. Virions in the liquid medium can be separated from the host cells by either centrifugation or filtration. Filters can physically remove anything present in the solution that is larger than the virions; the viruses can then be collected in the filtrate (Figure \(\PageIndex{1}\)).


1: Geometry and Complex Arithmetic. 2: Complex functions as Transformations. 3: Mobius Transformations and Inversion. 4: Differentiation: The Amplitwist Concept. 5: Further Geometry of Differentiation. 6: Non-Euclidean Geometry*. 7: Winding Numbers and Topology. 8: Complex Integration: Cauchy's Theorem. 9: Cauchy's Formula and Its Applications. 10: Vector Fields: Physics and Topology. 11: Vector Fields and Complex Integration. 12: Flows and Harmonic Functions