Machine learning is an effective method for software defect prediction. The performance of learning models can be affected by irrelative and redundant features. Feature selection techniques select a subset of most impactful relevant features that will result in higher accuracy and efficiency of models. This paper proposed a Cluster-based Hybrid Feature Selection method (CHIFS) for software defect prediction. A spectral cluster-based Feature Quality coefficient (FQ) was defined as a comprehensive measurement of feature relevance and redundancy. The final feature subset was iteratively selected from feature sequence ranked by FQ. The proposed CHIFS method was validated in the experiments using 3 classifiers with 15 open datasets from Promise Repository. Experimental results showed that the CHIFS method performed better than traditional methods in terms of accuracy and efficiency on a wide range of datasets.


s available online at http://meteoritics.org 1405 © Meteoritical Society, 2004. Printed in USA. THE ROLE OF NUCLEAR EXPLOSIONS IN STUDIES OF IMPACT CRATERS Dr. Bevan M. French's excellent personalized review article, The importance of being cratered: The new role of meteorite impact as a normal geologic process, in the February 2004 issue of Meteoritics & Planetary Science builds a strong case for impact as one of the primary processes affecting planets. His approach to this conclusion is taken from a historical perspective. He cites the year 1963 as a pivotal time, in which impact events came to be recognized as a common terrestrial occurrence. This foretold the eventual certification of impacts as a dominant means by which Earth-like planets and icy satellites around the giant planets have grown and modified their surfaces. However, probably because I do not recall that he attended, Dr. French left unmentioned a professional gathering the next year (May 16–19, 1964), in which key strides were made in proving the reality of impacts. This was the Conference on Geological Problems in Lunar Research, organized by Dr. Jack Green (later, at Long Beach State University) and sponsored by the New York Academy of Sciences, in which 58 papers covering both volcanic and impact cratering processes were given (and documented in volume 123, article 2, 1965 of the Annals of the Academy). Attendees were almost a "who's who" in the burgeoning field of cratering, guaranteeing a lively intercourse centered around the still (at that time) vigorous debate on the origin of the abundant craters spread over the Moon. Of the diverse treatments of cratering during the Conference, two can be cited as decisive because their linkage demonstrated that impacts have struck Earth many times in the past and, by inference, were probably the best explanation of most circular features on the Moon. One was given by Mr. Michael Dence of Canada's Dominion Observatory summarizing his studies of Canadian craters, and the second by myself, at the time working in the Plowshare program ("peaceful uses of nuclear explosions for such engineering projects as canal digging, oil and gas recovery, large-scale mining") being conducted at the Lawrence Radiation Laboratory in Livermore (later renamed the Lawrence Livermore Laboratory or LLL). To set the stage for the relevance of this pair of papers, some awareness of my background is needed. In his February 2004 paper, Dr. French has ably described what the "impacters" were basing their observations on and conclusions about the reality of the process. One of the central efforts was the program at the Dominion Observatory organized by C. S. Beals and carried out from a field and petrographic perspective by Michael Dence. When I arrived for the Conference, I was not cognizant of what that group had been learning. In 1959, a year after receiving my Ph.D. from MIT, I joined LLL, initially as the first geologist hired to support the Nuclear Weapons Testing Program because field detonations of nuclear explosive devices had gone underground the year before. I had no prior experience in anything related to this, having confined my studies to classical geochemistry, sedimentology, and structural geology. In the presence of physicists and engineers, I learned fast about the phenomenology of nuclear explosions. My job largely consisted of going into the ground zero section of an underground explosion, mapping it, and helping to define the parameters, recorded in the rocks, needed by the physicists in calculating the behavior of the nuclear device (mainly its yield in kilotons). But, the physical effects of the explosion on the rock or alluvium surrounding the device were of no particular interest to my LLL colleagues (most were focused on applications rather than research). That changed in the spring of 1960. A brilliant physicist, Dr. John Nucholls (who later became Director of LLL), had calculated (using a computer-based model) the mode of fracturing around a contained chemical explosion in the Winnfield (Louisiana) salt dome, part of the Cowboy program run jointly by DOD and the AEC to determine the degree to which explosions could be "muffled" (by being conducted in large mined-out spheres) to avoid detection during the Cold War. Dr. Nucholls (with insight I found rare in LLL physicists) wondered if the salt actually fractured as he predicted. I was assigned the task of mapping the actual fractures (which stood out as black filling by an injected carbon residue against the white salt) as I guided local miners who tunneled back into the bulged cavity around the detonated 1000 lbs of pelletol explosive. When I entered that cavity and collected salt from the edge, I noticed that the salt crystals had been deformed (I believe by plastic flow) into elongate shapes by the shock waves, and individual crystals showed sets of criss-crossing fracture or glide planes that fostered extension. At that moment, in just minutes, my career changed dramatically. I decided that someone should start examining, in detail, the rocks involved in chemical and nuclear explosions. I appointed myself and "bootlegged" these studies. As far as I know, I was the only person in the western world (I don't know about the Soviets) who actually studied nuclear explosion rocks in the early 1960s. Note


The present invention relates to a supply circuit acoustic signals from at least one loudspeaker (HP) incorporating a filter arrangement of the resonance peak of said at least one loudspeaker (HP) occurring at a given frequency, characterized in that the filtering device of the resonance peak of said at least one loudspeaker (HP) is incorporated in either the first circuit or instrumentation mass either in the feedback loop, this filtering device being purely electrical in the form an impedance incorporated in the first instrumentation ground circuit or in the feedback loop, the impedance parameters being predetermined as a function of the resonance peak filtering from said at least one loudspeaker (HP).


Abstract : The elasto-plastic buckling of rectangular plates made of inhomogeneous material when the modulus of elasticity, or shear modulus, and yield point change through the thickness of the plate, is examined. The elastic solutions method in combination with the finite differences and variation methods is used to solve the problem on the basis of the Kirchhoff-Love hypothesis. The condition of plasticity is considered in accordance with the energy theory and the material of the plates is assumed to be incompressible. (Author)


Background: Meningiomas have been reported to occur in approximately 50% of neurofibromatosis type 2 (NF2) patients. The NF2 gene is commonly biallelically inactivated in both schwannomas and meningiomas. The spectrum of NF2 mutations consists mainly of truncating (nonsense and frameshift) mutations. A smaller number of patients have missense mutations, which are associated with a milder disease phenotype. Methods: We analysed cumulative incidence and gender effects as well as the genotype-phenotype correlation between the position of the NF2 mutation and the occurrence of cranial meningiomas in a cohort of 411 NF2 patients with proven NF2 mutations. Results and Conclusion: Patients with mutations in exon 14 or 15 were least likely to develop meningiomas. Cumulative risk of cranial meningioma to age 50 years was 70% for exons 1-3, 81% for exons 4-6, 49% for exons 7-9, 56% for exons 10-13 and 28% for exons 14-15. In our cohort of 411 patients, we found no overall gender bias for occurrence of meningioma in NF2 disease. Cumulative incidence of meningioma was close to 80% by 70 years of age for both males and females, but incidence by age 20 years was slightly increased in males (male, 25%; female, 18%; p=0.023). Conversely we also found an increased risk of meningiomas in women with mosaic NF2 disease.


Undoubtedly the Quranic sciences is more deserving  for writing and composition and the study of Quranic  reading  comes  first  among  the  related  studies  of  this  science.  Books  of  interpretation  and syntaxes  of  the  Holy  Quran  are  full  of  these  types  of  related  readings  to  find  out  the  causes  and explanation; whether it is grammatical, morphological, lingual or moral.  One  of  the most  famous  books  that  took  care  of  it  is  the  book  (Al-Bahr Al-Moheet)  for Abu Hayyan Al-Andulusi  (745H); which  includes  several  opinions  of  a  large  groups  from  the  scholars  of Interpretations, Readings, Jurisprudence & Language.  In which the author has mentioned different names of the books that are still manuscript and haven't' been explained yet.   And among those books there is a book (Al-Lawamea Fi Shwath Al-Kara'aat) for Abu Fadhal Al-Radhi (454H) The  importance  of  this  topic  is  because  this  book  represents  the  important  circle  of  the writing groups  of  the  readings;  then  comes  the book  (Al-Mohtasib)  for  Ibn  Jinni  (392H)  and before  (Erab Al-Qira'at Al-Shwath) for Abu Al-Baqa Al-Akbari (616H) Whereas  in Al-Razi Book which consists of  the grammatical & morphological directions etc. the researcher decided to study it ; committing to his memory the words of the scholars about this readings, and the allegations and evidences of the Holy Quran & the Arab Sayings that they have quoted about it either  in  the  form of poem or prose, under  the  title of:  (Lights on  the Grammatical, Morphological & Lingual Explanations for Irregular readings as per the view of Abu Al-Fadhal Al-Razi) in his book (Al-Lawamea Fi Shwath Al-Kara'aat).


An output of a rotary or linear encoder of lower-precision (a subject encoder) is corrected according to that of higher-precision (a reference encoder) to provide higher precision output signals. In the present invention, a frequency multiplied pulse signal is obtained by multiplying a low precision output of a subject encoder by a multiplier. The number of pulses comprised in a portion of the multiplied pulse signal corresponding to a unit movement length of an object connected to the subject encoder is obtained by a hardware operation or by a program stored into a memory. A higher-precision output signal is obtained by dividing the frequency of the multiplied-frequency pulse signal of the subject encoder by a variable divisor corresponding uniquely to the number of high precision reference pulses between low precision subject encoder pulses when the object and the subject encoder are connected and moved. The various divisors can be stored as binary data consisting of high and low states corresponding to a unit movement length obtained by dividing the frequency of an output of the reference encoder at each pulse occurrence of the multiplied frequency pulse signal of the subject encoder. The storage for the divisors is preferably an EPROM which, along with the subject encoder, is connected to a calibration device for determining the high precision divisors. The EPROM and the subject encoder are removable from the calibration device for connection to an image reproduction device.


Background. To investigate legitimate transplantation in the United States with an Internet-identified live donor organ, from the patient's perspective, kidney centers were contacted by a researcher posing as an ideal patient and recipient pair seeking to find a center to perform their transplant. Methods. Responses were obtained with fewer than three phone calls and within less than 2 wk from 100 of 206 UNOS listed centers; 42 pediatric or inactive centers were excluded. Results. A total of 37% (76 of 100) indicated a willingness to consider such a transplant. Eight centers acknowledged having previously performed one, with 100% (8/8) of these indicating that they would still consider future participation. Conclusion. Large numbers of Internet-facilitated transplants are not yet being performed in the United States. Because it was possible to elicit a definite answer with 3 or fewer calls at only 49% of centers, we conclude that a significant proportion of centers are not providing easy access to potential donors and recipients. Agreeable centers were clustered geographically, suggesting that multiple factors may be influencing opinions. 100% of agreeable centers required their own standard evaluation of the donor and recipient and indicated that financial exchange between the pair was illegal. We conclude that Internet-based live donor kidney transplants are occurring and have received cautious acceptance at a significant number of legitimate centers. The utility of asking "How did the recipient-donor pair present to our institution" may no longer be relevant. We suggest that every pair seeking access to legitimate transplantation should undergo standardized evaluation with open acknowledgment of the relationship as a modifier.


When studying how conversationalists assess mutual understanding, research has focused on one type of evidence: next-turn talk. This article identifies another, antecedent type of evidence involving how talk is produced by reference to repair-opportunity spaces that are systematically provided for by conversation's generic organization of repair. As current speakers talk, recipients claim understanding ex silentio on an action-by-action basis as they forgo each next repair-opportunity space—that is, as they 'withhold' talk at each next transition-relevance place. This conversation-analytic article supports its argument through an analysis of multi-action/TCU turns generally, and specifically when recipients initiate repair on such turns with: "What?" In these cases, people respond by repairing only the most proximate action in their prior turn, which indexes their understanding that people who initiated repair understood relatively distal actions. Data are drawn from naturally occurring, ordinary, telephone conversations between friends and family members. Data are in American and British English.


Thin film CIGS modules on 0.43m/sup 2/ glass substrates are now being fabricated using a vacuum process suitable for large-scale production. Diagnostic techniques are described for monitoring the Cu-rich/Cu-poor transition, and for measurement of local I-V curves on a monolithic plate. Module powers up to 27.7 W (7.0% aperture area efficiency) have been achieved.


One of the peculiarities of communications policy is that those of us who are in the profession of offering advice on the subject are seldom called to account for the accuracy of our predictions. Success, in the main, comes to those who are most adept at persuading their clients of the accuracy of their own preconceptions; or at best, to those who are most successful in persuading governments of the cogency of their clients' case. Whether they were right in their analysis is something that only the effluxion of time can demonstrate; and by the time events have had a chance to prove or disprove their forecasts, the prophets have long since collected their fees and moved on, and clients and the public alike have forgotten, or ceased to care.


Chapfer I. A brief review is given of the history of diabetic retinopathy. In this chapter, the terms juvenile, middle-aged and older diabetics are defined. The terms are used according to onset of diabetes under the age of 20 years, between 20 and 40 years and over 50 years, respectively. Diabetics between the age of 40 ancl 50 years a t onset a re not grouped, as nearly half behave as middle-aged and the other half as older diabetics.


Ways of carrying out the individuality-oriented education in Dalian Yuming Senior School are presented.In order to promote student's all-round development,students'individual initiative should be aroused.Students should be taught in accordance with their aptitude to implement quality-oriented education.Remarkable achievements in teaching can be made by means of quality education.


The ongoing emergency situation associated with the spread of the coronavirus is already evident in its potential to cause serious consequences for society, the economy, and the population's psyche. Conversely, the most profound changes often emerge due to unforeseen circumstances that compel people to radically redefine their lifestyles. In such cases, we could potentially derive benefits from a serious situation to formulate future plans and adaptive work strategies. However, given recent events including the uncontrolled spread of the epidemic, the artificial escalation of panic, widespread quarantine measures, and other repercussions, one might expect chaos, crisis, and panic to prevail in many European countries. Italy, especially, should be susceptible to such issues as it held a prominent position in the COVID-19 incidence rankings for a considerable period. Nevertheless, there exist regions and individuals that remain impervious to crisis; their adaptability to any conditions is a skill honed over a prolonged duration. This article delves into the factors contributing to the relatively lower panic and epidemic spread in the southern Italian region of Calabria, specifically examining the role of the criminal subculture known as 'Ndrangheta. The study analyzes its business and organizational model, which has demonstrated its effectiveness to date and exhibited adaptability to modern lifestyles and changes.


This paper develops methods for reducing the complexity and, thereby, improving the linguistic interpretability of Takagi-Sugeno fuzzy systems that are learned online in a data-driven, incremental way. In order to ensure the transparency of the evolving fuzzy system at any time, complexity reduction must be performed in an online mode as well. Our methods are evaluated on high-dimensional data coming from an industrial measuring process.


Sufarce-enhanced Raman scattering and related surface-enhanced optical effects are summarized and shortly discussed. The possibilities for a spectroscopic application are considered and illustrated by some examples


The archaeological project of "Jesolo" began in 2011 through an archaeological survey in the countryside of the present day town of Jesolo by a team directed by Prof. Sauro Gelichi. The investigation focused on the archaeological site of the ancient Jesolo-Equilo, attested by the presence of the Romanesque Cathedral, built above other two older churches, and of the early medieval monastery of St. Mauro, founded probably during the 9th century (both sites were excavated in the mid-20th century). The archaeological survey was conducted by an interdisciplinary team composed by archaeologists and geologists because the objective of the research was not only to identify the Ancient and Medieval settlement, but also to recreate the ancient environment and its historical transformations. Nowadays the site is inland, but between Roman to the Middle Ages it was for sure a lagoon island and its importance is strictly related to the development of Venetian Lagoon during the Late Antiquity. During September 2013 we conducted the first campaign of excavation on the first cluster, that allowed us to collect a lot of data about the pattern of this settlement between the 4th and 7th century. In fact we found the remains of some structures well characterized by the type of building technique (bricks and clay) and of material culture (amphorae, coarse ware, sigillata, glass). The significant results of this first campaign allow us to compare this settlement to other important lagoon settlements like Torcello and Caorle, for example, that flourished during the same period. The part of the settlement that we explored seems abandoned in the second half of the 6th century, when the area was used as a cemetery. In fact we found 13 graves, dated for sure to the end of the 6th and the beginning of the 7th century (we found an "enchytrismos grave", inside an amphora from Gaza, dated to that period). Though just at its beginning, the project is giving a lot of interesting data to the historical comprehension of the development of the coastal settlement of this part of Adriatic Sea; the good preservation of archaeological deposit, besides the width of the area that could be explored, promise an excellent perspective of research. Parole chiave: insediamento, Tardoantico, sepolture, Hexaplex trunculus, fiume Piave.


Objective: to identify the care of nurses in the face of puerperal hemorrhages available in the scientific literature. Method: integrative review whose search was performed in the sources of information National Library of Medicine, Embase, Cumulative Index to Nursing and Allied Health Literature Scopus, Web of Science, Latin American and Caribbean Literature in Health Sciences and Scientific Electronic Library Online. Results: 31 precautions were found for the management of puerperal hemorrhages, the main ones being the measurement of vital signs and the new technology for blood measurement Quantitative Blood Loss. There was a lack of verification of vital signs and incorrect recording of cases that evolved into postpartum hemorrhage. Conclusion: postpartum hemorrhage can be prevented by nursing care. It is necessary that studies be made on the evaluation of the safety globe of Pinard, breastfeeding and mother and baby bond. And those new technologies, such as blood quantification, be added in institutional protocols.


Trade unions are legally recognized as official organizations representing and protecting workers rights and interests. They have to struggle to ensure the improvement of living standards of employees. This can be achieved through trade unions consciousness and participation in government's labour policies, member's commitment, and strong leadership. However, trade unions require favoring environment for their participation and rising voices, especially when governments and policies are silent about workers' rights or when workers benefits are at stake. This paper, for that matter, explores the major milestones for the development of trade unions in Tanzania since independence to present. It also assesses the conduciveness of environment for the operation of trade unions in Tanzania today. It is however, the opinion of this paper that, the environment for the operation of trade unions is still a mixture and not much favorable for the operation of trade unions. Keywords : Environment, Milestones, Trade unions


The invention discloses a photovoltaic grid connection control method on the basis of improved quasi-resonance control and repeated control. The photovoltaic grid connection control method includes steps of utilizing the difference between given grid connection current and actual output grid connection current of an inverter as input of a quasi-resonance controller and a repetition controller, utilizing the difference between the given zero direct current and the actual output grid connection current as input of an integral controller, adding the output of the quasi-resonance controller and the repetition controller as control signals of connection and disconnection of an inverter bridge switching tube in an inversion link. The photovoltaic grid connection control method combines the advantages of resonance control, repeated control and integral control, affection generated by grid voltage and frequency fluctuation can be effectively reduced, good dynamic and steady tracking performance is achieved, and optimal design of the grid connection control is benefited.


This chapter describes the development and evolution of the Partially Distributed Teams (PDTs) project, which is designed to prepare students to work in global teams. I discuss key milestones in its transition from a small project involv- ing regional teams into a global project where several thousand students have par- ticipated from over a dozen countries across five continents. I share my experiences as one example of how a small, "off-the-cuff" undertaking evolved into a large, sustained effort. I highlight my missteps along the way and the changes that ensued to improve the project and move it forward. The evolution of the project has been empirically driven, based on data collected from student participants as well as my own observations as project lead and participating instructor.


Aging is associated with vascular endothelial dysfunction, reduced exercise tolerance, and impaired whole‐body glucose metabolism. Interleukin‐37 (IL‐37), an anti‐inflammatory cytokine of the interleukin‐1 family, exerts salutary physiological effects in young mice independent of its inflammation‐suppressing properties. Here, we assess the efficacy of IL‐37 treatment for improving physiological function in older age. Old mice (26–28 months) received daily intraperitoneal injections of recombinant human IL‐37 (recIL‐37; 1 µg/200 ml PBS) or vehicle (200 ml PBS) for 10–14 days. Vascular endothelial function (ex vivo carotid artery dilation to increasing doses of acetylcholine, ACh) was enhanced in recIL‐37 vs. vehicle‐treated mice via increased nitric oxide (NO) bioavailability (all p < .05); this effect was accompanied by enhanced ACh‐stimulated NO production and reduced levels of reactive oxygen species in endothelial cells cultured with plasma from IL‐37‐treated animals (p < .05 vs. vehicle plasma). RecIL‐37 treatment increased endurance exercise capacity by 2.4‐fold, which was accompanied by a 2.9‐fold increase in the phosphorylated AMP‐activated kinase (AMPK) to AMPK ratio (i.e., AMPK activation) in quadriceps muscle. RecIL‐37 treatment also improved whole‐body insulin sensitivity and glucose tolerance (p < .05 vs. vehicle). Improvements in physiological function occurred without significant changes in plasma, aortic, and skeletal muscle pro‐inflammatory proteins (under resting conditions), whereas pro‐/anti‐inflammatory IL‐6 was greater in recIL‐37‐treated animals. Plasma metabolomics analysis revealed that recIL‐37 treatment altered metabolites related to pathways involved in NO synthesis (e.g., increased L‐arginine and citrulline/arginine ratio) and fatty acid metabolism (e.g., increased pantothenol and free fatty acids). Our findings provide experimental support for IL‐37 therapy as a novel strategy to improve diverse physiological functions in old age.


Often hailed as a revolutionary new technology, NANOTECHNOLOGY has the potential to impact almost every area of the society. One area in nanotechnology that holds promising great benefits for the society in future and is in the realm of medicine is NANOMEDICINE. Among which comes our core of the study SILVER NANOPARTICLES which has shown great affirmation in terms of biomedical applications, not only due to their large surface area to volume ratio, but also because they exhibit different biomedical activities. Antibacterial efficacy of Silver nanoparticles synthesized from the extract of guava fruit ( Psidium guajava ) were tested against multi drug resistant strains of Gram negative bacteria isolated from diabetic foot ulcer patients by agar well diffusion method. Antibacterial activities of the silver nanoparticles were compared with the conventionally used antibiotics. Silver nano particles showed maximum inhibition against MDR strains Pseudomonas aeruginosa, E.coli, Klebsiella pneumoniae, Proteus mirabilis and Acinetobacter baumannii . The aim of this in vitro study is to examine the efficacy of silver nanoparticles in treating bacterial infections from diabetic foot ulcers patients. The findings implicating that the silver nanoparticles have effective antibacterial actions than the commonly used antibiotics. We conclude, silver nanoparticles are now considered a viable alternative to antibiotics and seem to have a high potential to solve the problem of the emergence of bacterial multidrug resistance on diabetic foot ulcer infections.


A non-linear mathematical model of hyperbolic thermoelastic continuum with fine microstructure is proposed. The model is described in terms of 4-covariant field theoretical formalism. Fine microstructure is represented by d-tensors, playing role of extra field variables. A Lagrangian density for hyperbolic thermoelastic continuum with fine microstructure is given and the corresponding least action principle is formulated. 4-covariant field equations of hyperbolic thermoelasticity are obtained. Constitutive equations of microstructural hyperbolic thermoelasticity are discussed. Virtual microstructural inertia is added to the considered action density. It is also concerned to the thermal inertia. Variational symmetries of the thermoelastic action are used to formulate covariant conservation laws in a plane space-time. For micropolar type II thermoelastic Lagrangians following the usual procedure independent rotationally invariant functional arguments are obtained. Objective forms of the Lagrangians satisfying the frame indifference principle are given. Those are derived by using extra strain vectors and tensors.


Pyogenic granuloma (PG) is an inflammatory hyperplasia of the tissues that occurs as a result of various stimuli such as low-grade local irritation, traumatic injury, or hormonal factors. The term used is a misnomer since it is unrelated to infection and does not contain pus. Clinically, oral PG develops as a solitary, granuloma-like, pedunculated, and easily bleeding tumor which mostly affects the gingiva followed by buccal mucosa, tongue, lips, and palate. It is also known as granuloma pyogenicum, granuloma gravidarum, telangiectatic granuloma, pregnancy tumor, vascular epulis, benign vascular tumor, and hemangiomatous granuloma. Females are affected more commonly mainly during puberty, pregnancy, and menopause probably due to the vascular effects of the hormones. The lesions are known as "pregnancy tumor" and tend to occur more frequently during the second and third trimesters. Commonly involved treatment protocols include conventional surgical excision, electrocautery, and lasers. The purpose of this article is to report the laser-assisted management of an unusual case of PG in a 22-year-old female patient in her 9th month of pregnancy.


In Indonesia, many organophosphate pesticides used on fruit crops and vegetables such as onion, tomato, lettuce, and beans. Organophosphate pesticides has translocation to all parts of the plant, so organophosphate pesticide residues can be left in onion that consumed by the person. In Kulon Progo, Yogyakarta organophosphate pesticides are Media Farmasi Vol. 14 No.2 September 2017 : 128-138 129 widely used especially by onion farmers.The research method used observational and experimental design. Samples were taken from 10 onion in Kulon Progo. The questionnaires were distributed to farmers on the types of pesticides used and the time applied by farmers as well as the frequency of the use of pesticides. Determination of organophosphates used extraction process with acetone, dichloromethane, and benzene peroleum as solvent then analyzed by GC. The results of a questionnaire to onion farmers, organophosphate pesticide used is the active ingredient diazinon, profenofos, and klorpirifos with an average usage of 1.5% (v / v). The results of the analysis of the active ingredient diazinon, profenofos, and klorpirifos showed the results of successive 3.7 ppb, 4.8 ppb, and 0.83 ppb with a detection limit respectively 3.7 ppb, 4.8 ppb, and 0.83 ppb. GC analysis also showed only onions from one farmer containing pesticides diazinon levels of 1.97 ppb.


Single ventricle patients are born into a world of ambiguity, uncertainty and a future that may never come. Surviving the Fontan operation and entering adulthood should be cause for respite, but for many patients, growing older also means coping with new problems and comorbidities. This is counterbalanced with hope and data suggesting our modern Fontan patients are doing better—with 20 and even 30year survival rates approaching 80%–90%. However, focusing solely on survival is no longer an acceptable benchmark for patients or their physicians; instead, we strive for an exceptional quality of life, which means minimising comorbidities. Fontanassociated liver disease (FALD) is one of those conditions difficult to define, yet somewhat intrinsic to the Fontan circulation. This duality of this diagnosis, being both ambiguous and inevitable, is what makes FALD so unnerving for our patients. Francis Fontan's publication describing the original operation that bears his name was published in 1971. It would take another 10 years before the first report of an autopsy on a Fontan patient described a liver with nutmeg appearance and histological evidence for cirrhosis. An additional 24 years would pass before an autopsy series of nine patients would provide us a broader understanding that the longterm sequelae of Fontan physiology have a spectrum of findings resulting in chronic hepatic venous congestion, liver cirrhosis (LC), hepatic adenoma and hepatocellular carcinoma (HCC). Eventually, we would add hepatic fibrosis and focal nodular hyperplasia to the clinical picture and group all of these outcomes under the heterogeneous moniker of FALD. Numerous aspects of Fontan physiology (central systemic venous hypertension, low cardiac output, cyanosis, lymphatic congestion, cardiopulmonary bypass, etc) create a perfect physiological storm and an intuitive understanding of why there would be consequences for the liver. Additional published data and more frequent use of the label FALD have raised awareness and sensitivity to liver disease in this population. While this is an important advancement in our field, it has also come at a cost, as the label FALD is nonspecific and somewhat universal resulting in increased anxiety for patients and providers. While this connection between liver disease and Fontan physiology is 40 years old, we (as a field) have still struggled to define, diagnose and manage this condition. In this issue of the journal, Inuzuka et al try to add to our understanding of the incidence and aetiologies of FALD. They report a large multiinstitutional retrospective cohort study of 1260 patients after the Fontan operation. A critical issue in this study, and for our discipline as well, is how should FALD and its specific clinic phenotypes be diagnosed. Transcutaneous biopsy is currently the gold standard, but has limitations associated with sampling error, need for sedation and bleeding complications. Transhepatic biopsy may minimise some of these risks but has generally lost favour due to underestimating fibrosis from increased sampling error. These barriers have resulted in biopsy being underused both in research studies and on a clinical routine basis. Similarly in this paper, only 3 of the 78 patients had percutaneous liver biopsy data to diagnose LC and/or HCC. The remainder (96%) of the patients had the diagnosis of LC made by noninvasive imaging testing: ultrasonography (US), contrastenhanced CT or MRI. The authors used imaging findings of contour nodularity, blunt margins, right hepatic lobe atrophy, caudate or left hepatic lobe hypertrophy (excluding symmetric liver in heterotaxy syndrome), and/or extrahepatic features (varices or congestive splenomegaly) as a composite imaging surrogate to diagnose LC based on a paper of 142 adults from 2008. These diagnostic criteria came from adults without Fontan physiology with modest sensitivity values of 38%, 77%, and 68% for US, CT, and MRI, respectively. Specificity was also modest with values of 89%, 68%, and 68% for US, CT, and MRI, respectively. It is therefore important to note that the authors' ability to diagnose LC depends on the imaging modality type and may only modestly be associated with biopsyproven LC. It is also relevant to mention that these diagnostic criteria may or may not translate to patients with Fontanassociated LC. Similar caution should be applied to the diagnoses of liver fibrosis or HCC, as imaging was the predominant diagnostic modality. Acknowledging these diagnostic limitations, the cumulative incidence of FALD is very high and increases with time after the Fontan operation. The authors report that at 20 years after the Fontan operation, the incidence of liver fibrosis, LC, and HCC was 25%, 12%, and 0.8%, respectively. These findings are consistent with other studies and give us 'unhealthy' respect for the hepatic sequelae of the Fontan circulation. More significant, a diagnosis of LC or HCC by these criteria was associated with a 5year mortality rate of 25%. One of the most important findings from this study was the multivariableadjusted Cox model showing that elevated central venous pressure (CVP) and the presence of severe atrioventricular valve regurgitation (AVVR) at time of catheterisation (generally 1 year after Fontan) were independently associated with future development of LC or HCC. Highlighted in figure 3, the 20year probability of LC or HCC seems to have an important inflection point for CVP values >15 mm Hg. Given the limitations above, if these models are translatable to a larger generalised population of Fontan patients, these two variables deserve heightened scrutiny as potentially modifiable risk factors to prevent the more significant phenotypes of FALD. The association of elevated CVP and LC/HCC is not surprising based on our understanding of the pathogenesis of FALD. It should be acknowledged that the CVP readings were taken from a single time point and this study does not give us information about changes in CVP over time and how those changes may or may not be associated with LC/HCC. In addition, this study does not provide any data or insights into the role that fenestration management may play in decreasing or increasing the progression of FALD. Some have hypothesised that maintaining longterm fenestration patency could decrease the incidence of FALD by lowering CVP and providing a 'popoff ' during exercise or respiratory illness. The data to support this claim are unfortunately lacking but could be the target of future studies. Regardless, the association of elevated CVP and LC/HCC does support management strategies that decrease CVP. These data would support the rationale for Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA


cause of this last phenomenon is still unknown. In the discussion following Dr. Helmer's paper, the point was again made that the daily variations of circulating renin levels can be quite high; they seem to depend upon whether the person has exercised or not and even on the position of the blood donor, whether he is standing upright or in a recumbent position. Dr. Helmer mentioned that at present he is studying labile hypertensive patients and that he has only preliminary results but feels he can detect variations in the amount of renin. In the discussion following Dr. Hoobler's paper, Dr. Helmer mentioned that renin substrate levels increase after nepbrectomy; this was verified by Dr. Skeggs. Dr. Wilson mentioned that a paper presented by Bing in Prague reported an increased rate of production of angiotensin after nephrectomy, although Dr. Hoobler could not find any difference in rate. In the discussion following Dr. Masson's paper, Dr. Wilson mentioned that he could confirm the finding of vascular lesions after injection of kidney extracts into nephrectomized rats. Although no similar lesions could be determined after subcutaneous injection of hogrenin into nephrectomized rats, it was suggested by a number of participants that renin could not be rejected as a causative agent until homologous renin was used. Dr. Deodhar was asked whether he had used his dog antirenin, which shows a cross-reaction with human renin, in essential hypertensive patients. This had not yet been done, but Dr. Deodhar and his colleagues are in the process of collecting enough antirenin to begin a study with patients.


In their target article, Leon and Antonelli-Ponti propose that regions of countries subject to higher levels of UV radiation tend to have lower average IQs. They cite supporting evidence from Italy, the United States and Brazil. The present comment tests their theory using data from the United Kingdom. Contrary to the theory, average IQ among white British is higher in the southern regions of the country, where solar radiation is more intense. In fact, the cross-regional correlation between intensity of solar radiation and average IQ among white British is positive. Leon and Antonelli-Ponti's theory is therefore incapable of explaining regional IQ differences in the UK.


Training Deep Neural Networks (DNN) concurrently is becoming increasingly important for deep learning practitioners, e.g., <italic>hyperparameter optimization (HPO)</italic> and <italic>neural architecture search (NAS)</italic>. The GPU memory capacity is the impediment that prohibits multiple DNNs from being trained on the same GPU due to the large memory usage during training. In this paper, we propose <italic>Waterwave</italic>, a GPU memory flow engine for concurrent deep learning training. First, to address the memory explosion brought by the long time lag between memory allocation and deallocation time, we develop an allocator tailored for multi-streams. By making the allocator aware of the stream information, a <italic>prioritized allocation</italic> is conducted based on the chunk's <italic>synchronization</italic> attributes, allowing us to provide useable memory after scheduling rather than waiting it to be really released after GPU computation. Second, <italic>Waterwave</italic> partitions the compute graph to a set of continuous <italic>node groups</italic> and then performs finer-grained scheduling: <italic>NodeGroup pipeline execution</italic>, to guarantee a proper memory requests order. <italic>Waterwave</italic> can accomplish up to 96.8% of the maximum batch size of solo training. Additionally, in scenarios with high memory demand, <italic>Waterwave</italic> can outperform existing spatial sharing and temporal sharing by up to 12x and 1.49x, respectively.


Introduction 1. The synagogue of Satan: anti-Catholicism, false doctrine and the construction of contrariety 2. Temptation: the Protestant dynamic of diabolic agency and the resurgence of clerical mediation 3. Satan and the godly in early modern England 4. Incarnate devils: crime narratives, demonization and audience empathy 5. 'What concord hath Christ with Belial': de facto satanism and the temptation of the body politic, 1570-1640 6. 'Grand Pluto's progress through Great Britaine': the civil war and the zenith of satanic politics 7. 'The Devil's Alpha and Omega': temptation at the cutting edge of faith in the civil war and the interregnum Conclusion Bibliography Index.


Persistent fever without focus but with lymphadenopathy: infection, inflammation or malignancy?

Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disease in which four cardinal signs have been described: rash, spiking fever, arthritis or arthralgia and hyperleucocytosis with neutrophilia. Nevertheless, diagnosis can be challenging as infectious, other inflammatory or neoplastic diseases need to be ruled out. It affects typically young adults (from 16 to 35 years). The disease can be controlled with non-steroidal anti-inflammatory agents and glucocorticoids. To date, treatments as Il-6, IL-1 or anti-TNFα can be used in glucocorticoid-dependent or refractory patients. We present a case of a 22-year old woman with all four cardinal symptoms in which all cultures and infectious serology resulted negative. Also, auto-immune markers were negative. Because of diffuse bilateral supra- and infradiaphragmatic enlarged lymph nodes up to 1.6 cm in size on computed tomography (CT), additional positron emission tomography-computed tomography imaging (PET-CT-scan) was performed. Besides the multiple enlarged lymph nodes, increased tracer capture was shown in the spleen and bone marrow. All of this was suspicious for high-grade lymphoma. Eventually, an additional bone marrow biopsy with aspiration and lymph node biopsy could rule out a lymphoproliferative process and the diagnosis of AOSD could be made. This case report highlights the importance of a profound diagnostic work-up in fever of unknown origin.


The main objective ofthis paper is to determine the spectrum and the fine spectrum ofthe difference operator $\Delta_i^2$ over the sequence spaces $c_0$ and $\ell_1$. For any sequence $x=(x_k)$ in $c_0$ or $\ell_1$, the generalized difference operator $\Delta_i^2$ over $c_0$ or $\ell_1$ is defined by $(\Delta_i^2(x))_k =\sum_{i=0}^2\frac{(-1)^i}{i+1}\binom{2}{i}x_{k-i}=x_k-x_{k-1}+\frac{1}{3}x_{k-2}$, with $x_k = 0$ for $k < 0$. Moreover, we compute the spectrum, the point spectrum, the residual spectrum and the continuous spectrumof the difference operator $\Delta_i^2$ over the basic sequencespaces $c_0$ and $\ell_1$.


B cell‐defective (CBA/N × BALB/c)F1 male mice have 100 times less lipopolysaccharide‐reactive and 10‐100 times less lipoprotein‐ and Nocardia mitogen‐reactive B cell precursors than F1 female mice with normal B cells.


Experiments on domestic animals such as the cow have contributed much to our knowledge of endocrine mechanisms especially concerning the regulation of luteal cell function. Luteinizing hormone (LH) and prolactin were measured by radioimmunoassay and progesterone by competitive protein-binding. Basal levels of LH were around 1 ng/ml but had very dramatic increases 1 2 or 3 times during the female cycle. Prolactin was present in concentrations of 5-100 ng/ml but exhibited tremendous diurnal variations. A steadier secretion rate is characteristic of progesterone; therefore for the latter hormone random values may be meaningful even if samples are not taken several times a day as is necessary for the pituitary hormones. The information obtainable under physiological conditions from the peripheral blood hormone levels concerning luteal cell function are very limited. The relationship of LH to progesterone can be seen mainly by the effect of exogenous administration of LH-like material and of anti-LH serum; endogenous LH peaks during the cycle at periods when luteal tissue is present indicated its possible luteotropic activity by producing elevated progesterone levels. The dominant feature of prolactin levels in blood is the large diurnal variation so that apart from a distinct peak around parturition no reproducible relationship to reproductive performance is demonstrable. The picture of pituitary-ovarian relationship is complicated by a negative feedback mechanism from ovarian steroids to the gonadotropins.


The goal of health care is to optimize both quantity and quality of life for patients. Among select patients with severe symptomatic aortic stenosis, transcatheter aortic valve replacement (TAVR) can, on average, improve both survival and health status (i.e. symptoms, functional status, and quality of life).1,2 Yet, the technology is currently limited to patients who are either ineligible or at high risk for open surgical AVR. The result is that TAVR is used in older patients with multi-morbidity and frailty. As such, success is far from guaranteed for each of these complex cases. Indeed, despite the overall benefits seen in the Placement of AoRTic TraNscathetER Valve (PARTNER) trial, approximately 1 in 5 patients undergoing TAVR died within 6-months.3 An unmet need is to better determine, prior to TAVR, which individual patients are unlikely to achieve a "good" outcome.


\Handbook of Neuropsychology, Vol. 6 (Child Neuropsychology, Section 10, Part 1)

edited by I. RAPIN and S.J. SEGALOWITZ, 503 pp., Amsterdam, Elsevier Science Publishers, 1992. $268.00.

Handbook of Neuropsychology, Vol. 7 (Child Neuropsychology, Section 10, Part 2)

edited by S.J. SEGALOWITZ and I. RAPIN, 478 pp., ill., Amsterdam, Elsevier Science Publishers, 1992. $294.00

It is symptomatic of the growth of child neuropsychology in the last 15 …


OBJECTIVE Somatostatin analogues have been proposed for the treatment of thyrotrophinomas. However, this treatment requires several s.c. injections a day to be effective. The present study had the following aims: (i) appraisal of the efficacy of a single dose of two somatostatin analogues (lanreotide and octreotide) to acutely inhibit TSH secretion of TSH‐secreting pituitary adenomas; (ii) assessment of the efficacy of a single injection of a slow release formulation of lanreotide (SR‐L) in reducing TSH and thyroid hormone secretions in the same cases; and (iii) evaluation of the effects of SR‐L used for 3–6 months on hormone secretion and tumour size.


Robert Gagné was an American educational psychologist who's ideas of conditions of learning and instructional design implications were first introduced in 1965. Gagné assumed that there are different types of learning outcomes, each of which is best achieved through its specific instructional design, but also that there is a set of steps required in every learning environment (sometimes also known as the Gagné Assumption).


Alternative splicing is emerging as a prevalent mechanism for altering protein expression in response to environmental cues. We have recently found that, upon activation by antigen, T cells undergo coordinated changes in alternative splicing. As a model system to explore the mechanisms of signal‐induced alternative splicing in T cells my group has been studying the regulated splicing of the CD45 gene. The CD45 gene, which encodes a transmembrane protein tyrosine phosphatase, has three variable exons that are differentially excluded in T cells upon antigen challenge. An exonic splicing silencer element (ESS1) exists in each of the CD45 variable exons, and also exhibits homology to exons of other signal‐responsive genes. Using a variety of biochemical approaches we have identified a complex of hnRNP proteins that associates specifically with the ESS1 sequence and promotes exon skipping. Strikingly, repression of splicing by the ESS1‐bound complex appears to occur by a mechanism distinct from those previously described for exon skipping. Moreover, while all of the proteins within the ESS1‐bound complex are present in resting cells, only a suboptimal subset bind to the ESS1 prior to stimulation. The mechanism of this differential RNA association is currently being investigated.


Abstract This paper takes as a case study broadcasts produced by Radio Free Europe/Radio Liberty (RFE/RL), exploring efforts by the Hoover Institution Library & Archives (HILA) at Stanford University to build a transnational archiving consortium with other repositories for RFE/RL content across Europe and North America. Addressing the successes and limitations of these efforts, the paper argues the continued need and value for coordination of radio preservation efforts across national boundaries, while flagging some of the logistical difficulties that such work entails


Diffusion Tensor Imaging (DTI) is a new Magnetic Resonance Imaging (MRI) method that is newly used in clinical practice with no traumatic advantages, which can quantitatively analyze the microstructure of the brain, such as quantitative analysis of the dispersion characteristics of
 lesions and normal tissues, thus providing more information for the diagnosis and differential diagnosis of diseases. At the same time, DTI has a unique advantage in the imaging of white matter fibers in the brain, can visually show the relationship between intracranial lesions, especially
 tumors and autologous fibers, more conducive to guiding the operation, in order to maximize the removal of tumors and protect functional areas. In order to make the dispersal volume better applied to clinical, this topic mainly hopes to provide a new basis for the benign-malignant classification
 of brain tumors and the diagnosis of different brain tumors, FA (fractional anisotropy) value. It can provide a stronger basis for the diagnosis of brain tumors, which is rarely done in previous research institutes. Previous studies have rarely dealt with the signal strength of FA diagrams,
 and extensive research in this area is needed. It is hoped that the signal strength of FA graphs will help diagnose different tumors and grade the malignant degree of brain tumors. Through this experiment, it can be proved that this purpose can be achieved by magnetic resonance dispersion
 volume imaging. In this study, a comparative analysis method was used to determine the ADC and FA values on the magnetic resonance dispersion weighted image and dispersal volume image of glioma and benign malignant meningioma, thus revealing the important role of this method in the diagnosis
 and differential diagnosis of tumors in the brain and its application value.


Survival of an X-ray-resistant hybrid cell line $({\rm HD}_{1})$ and a normally responsive cell line $({\rm H}_{4})$ have been compared when irradiated under induced hypoxia by both protons and X rays. The two cell lines are similarly protected when irradiated under hypoxic conditions with oxygen enhancement ratios of 2.8 and 2.7, respectively. The protection is consistent with a dose-modifying factor. No statistically significant difference is observed between cell inactivation by X rays and protons in either cell line, whether irradiated under aerobic or hypoxic conditions.


In the health sciences, many data sets produced by next-generation sequencing (NGS) only contain relative information because of biological and technical factors that limit the total number of nucleotides observed for a given sample. As mutually dependent elements, it is not possible to interpret any component in isolation, at least without normalization. The field of compositional data analysis (CoDA) has emerged with alternative methods for relative data based on log-ratio transforms. However, NGS data often contain many more features than samples, and thus require creative new ways to reduce the dimensionality of the data without sacrificing interpretability. The summation of parts, called amalgamation, is a practical way of reducing dimensionality, but can introduce a non-linear distortion to the data. We exploit this non-linearity to propose a powerful yet interpretable dimension reduction method. In this report, we present data-driven amalgamation as a new method and conceptual framework for reducing the dimensionality of compositional data. Unlike expert-driven amalgamation which requires prior domain knowledge, our data-driven amalgamation method uses a genetic algorithm to answer the question, "What is the best way to amalgamate the data to achieve the user-defined objective?". We present a user-friendly R package, called amalgam, that can quickly find the optimal amalgamation to (a) preserve the distance between samples, or (b) classify samples as diseased or not. Our benchmark on 13 real data sets confirm that these amalgamations compete with the state-of-the-art unsupervised and supervised dimension reduction methods in terms of performance, but result in new variables that are much easier to understand: they are groups of features added together.


An airspeed display and a lateral displacement (runway) display, arranged vertically and horizontally, respectively, were concurrently tracked by relatively inexperienced pilots using a joy stick. On each display the primary indicator was a small band which moved lengthwise. A moiré-pattern rate field (RF) moved alongside and with the primary. Each of four experimental conditions included both primary indicators and (a) no rate fields, (b) the airspeed rate field only, (c) the runway rate field only, or (d) both rate fields. Response measures for each display included (a) latency of initial response, (b) control reversals, and (c) root-mean-square (RMS) tracking error. Rate fields decreased RMS error for the runway display. Latency was briefer, but more reversals occurred on the airspeed display than on the runway display. Rate fields apparently serve an attention gathering function, but this cannot be fully investigated until optimum direction-of-motion relations are determined.


Abstract : The main overall goal of this project was to improve the high speed performance of transistors and integrated circuits based on silicon, which is the material on which most microelectronic circuitry (such as microprocessors and memory chips) is based. This project examines the scaling of MOSFET's to very small channel dimensions using a vertical structure which is defined by Rapid Thermal Chemical Vapor Deposition. The scaling of vertical p-channel MOSFET's with the source and drain doped with boron during low temperature epitaxy is limited by the diffusion of boron during subsequent side wall gate oxidation. By introducing thin SiGeC layers in the source and drain regions, this diffusion has been suppressed, enabling for the first time the scaling of vertical p-channel MOSFET's to under 100nm in channel length to be realized. Device operation with a channel length down to 25nm has been achieved.


In case of a radiation accident, it is well known that in the absence of physical dosimetry biological dosimetry based on cytogenetic methods is a unique tool to estimate individual absorbed dose. Moreover, even when physical dosimetry indicates an overexposure, scoring chromosome aberrations (dicentrics and rings) in human peripheral blood lymphocytes (PBLs) at metaphase is presently the most widely used method to confirm dose assessment. The analysis of dicentrics and rings in PBLs after Giemsa staining of metaphase cells is considered the most valid assay for radiation injury. This work shows that applying the fluorescence in situ hybridization (FISH) technique, using telomeric/centromeric peptide nucleic acid (PNA) probes in metaphase chromosomes for radiation dosimetry, could become a fast scoring, reliable and precise method for biological dosimetry after accidental radiation exposures. In both in vitro methods described above, lymphocyte stimulation is needed, and this limits the application in rad...


Package electromigration tests were performed on dual damascene copper interconnects issued from the 90, 65 and 45 nm-node technologies. By varying the stress conditions during the steady state regime of the resistance increase, we study drift velocity evolution as a function of the current density j. Thus we show some large deviation of the Black's law, which assumes a linear dependence of the lifetime with j. Finally we have determined the Black's exponent n in a broad range of current density j (2.5-50 mA/mum2). For 250 mum long lines, a n=1 is obtained between 10 and 20 mA/mum2, it increases up to 2 for j=2.5 mA/mum2.


Abstract Thromboplastic cell component (TCC) and thromboplastic plasma component (TPC) together but not separately have an activity identical with that of tissue thromboplastin lipoprotein in the extent and in the rate of prothrombin conversion. The results indicate a stoechiometric rather than a kinase-zymogen relationship between these two blood components. TCC is a lipoprotein isolated by high gravity centrifugation of blood cell extracts. TPC is found in the non-clottable globulins of plasma Fraction I. Therefore, all the biochemical factors essential for coagulation can be obtained individually in measurable quantities from human blood alone. A concept of the coagulation mechanism not involving tissue thromboplastin is presented and discussed.


These considerations were envisaged long ago by Jackson when he spoke of the influence of the "four factors of the insanities." The factors as he originally set them out in 1874 were: (1) the depth of the dissolution or reduction; (2) the rapidity of the reduction; (3) the kind of brain in which the reduction occurs; and (4) the influence of external circumstances and internal bodily states on the patient who is reduced. It is Jackson's third factor Which augurs so well for future investigations.


A novel 6-PUS parallel engraving machine is presented. Based on the selected mechanism type, the mecha-nism performances are analyzed in terms of the first and the second order influence coefficient matrixes. So the sizes of themechanism, which are better for all the performance indexes of both kinematics and dynamics, can be determined and therestriction due to considering only the first order influence coefficient matrix in the past is broken through. Therefore, thetheory basis for designing the mechanism size of novel engraving machine with better performances is provided. Keywords:parallel mechanism; engraving machine; influence coefficient; performance index


Architecture and culture constantly interact with each other. Since the vernacular housing is built based on experience within the framework of the user's wishes and needs; it reflects both individual and social life strongly. Thanks to its unique spatial, structural and aesthetic features, "Turkish House" is a very important cultural heritage. In accordance with the lifestyle of the Turks, it has been shaped within the framework of principles such as adaptation to nature and the built environment, rationality, functionality, internal-external harmony (legibility), frugality, humanistic measures, regionalism, and flexibility. In this direction, the study aims to reveal the spatial organization of Yalvaç Tıraşzade Mansion within the framework of the "Turkish House". Turkish family life, social organization, climate characteristics of Central Anatolia, local riches, local acceptances are reflected in the spatial setup, facade, and details of Yalvaç Tıraşzade Mansion. In order to show this reflection, the building has been analysed over the cultural facts. In the study, where literature review and on-site observation were applied together as a method, a fiction flowing from the general view to the detailed examination of the case was chosen.


In this paper, we have calculated the energy spectrum of 12C isotope by cluster model. The experimental results show that the "Hoyle" state at 7.65 MeV in 12C isotope has a well-developed three-alpha structure. Hence, we select a three-body system and for interaction between the clusters we use modified Yukawa potential plus coulomb potential. Then, we solve the relativistic Klein-Gordon equation using Nikiforov-Uvarov method to calculate the energy spectrum. Finally, the calculated results are compared with the experimental data. The results show that the isotope 12C should be considered as consisting of three-alpha cluster and the modified Yukawa potential is adaptable for cluster interactions.


This paper tests the rationality of indicator system through a comparative study on the competitive power of the 41 mountain areas from nine aspects,for example,economic strength using multicollinearity and ANOVA methods.Taking Dehua county as an example,the paper analyzes its synthetic competitive power and its advantages and disadvantages,and puts forward brief proposals.


Mining and quarrying industry is considered as an i mportant industry since it provides several importa nt natural resources used in energy, manufacturing and other sectors. The effici ncy of this industry is then recommended to be mea sur d, evaluated and improved. In this article, we have measured the efficiency of mi ning and quarrying industry of Visegrad 4 countries . There is a gap in the research of mining and quarrying industry efficiency research i n the Central and Eastern European region. We have used modern, widely used method – two-step data envelopment analysis. This method is con idered as the most used method of evaluating th e efficiency. In the first step, we calculated the efficiencies of countries during the period 2011-2015. The results show that the Slovak Republic is the most inefficient country. Then, using the double bootstrapped effici ncies, which diminish disadvantage of Data Envelop ment Analysis (DEA) – determinacy, and then truncated regression, we calculated the re gressors of efficiency explaining the model, we hav e proposed. The results of the model show that Gross investments in machinery and equipm ent, Gross investments in construction and alterati on of buildings and Human Development Index (HDI) have a positive impact on efficiency. On the contrary, results have shown tha t ere is still relatively small amount of inefficient investments. Results proved t hat there could be exogenous factors of explaining the efficiencies, in our case the HDI index.


Early intervention In Portugal is an emerging service. Until recently services were child centered using the same methods used by special education with older children. The Coimbra Project was undertaken to develop the first coordinated, multidisciplinary, interagency program involving health care, education, and social service, using existing resources In the community. The program now operates regionwide and supports more than 100 families and children with disabilities or at environmental risk. In spite of economic constraints, program success is increasing awareness of the need to integrate and coordinate multiple community agencies and to develop regulations on the provision of services.


Evolutionary biologists are increasingly interested in testing alternative models rather than simply presenting plausible explanations for their observations. Although most biologists agree that significant phenotypic changes cannot occur without natural selection, it is useful to have statistical tests that reject alternative mechanisms such as genetic drift and mutation. The first such tests were presented by Lande (1976, 1977). This note reviews previous analyses of neutral phenotypic evolution and concentrates on tests derived from two simple approximations. One describes neutral macroevolution in populations that have achieved an equilibrium level of heritable variation determined by mutation and genetic drift; the other (developed explicitly in Lande [1976, 1977]) describes neutral microevolution in recently established populations whose levels of heritable variation may be far from mutationdrift equilibrium. As our examples below demonstrate, average rates of macroevolutionary change are rarely fast or slow enough to provide sufficient evidence for rejecting neutral models. Although we state our results in terms of statistical tests, the sampling errors for many of the parameters are unknown. Thus our results are best viewed as qualitative assessments of the agreement of evolutionary rates with the expectations from simple neutral models. Lande (1976) applied quantitative-genetics theory to describe two fundamental processes that can change phenotypic means: natural selection and genetic drift. He first estimated the minimum intensity of truncation selection necessary to produce a specific change (see Charlesworth [1984a) for an analysis of another mode of selection); then, he calculated the maximum effective population size, denoted N, *, that would allow genetic drift to produce the same phenotypic change by random sampling. From this stochastic model, Lande (1977) developed a "rate test" for the hypothesis that drift alone could account for observed divergence among the mean phenotypes of reproductively isolated populations. Charlesworth (l984b) has developed related tests for the null hypothesis that evolutionary rates remain constant within lineages. All of these tests, including the ones discussed below, assume that changes in mean phenotype are caused by genetic changes rather than direct phenotypic responses to changing environmental conditions. An implication of Lande's (1976) test, which rejects neutrality if N, > Ne*, is that genetic drift changes the mean phenotype more rapidly in small populations than in large ones. This contradicts Kimura's (1968) original neutral theory of molecular evolution, which predicts that the rate of molecular evolution is independent of population size and is governed wholly by the rate at which neutral mutations arise. The reason for this discrepancy is that Lande's (1976) test treats the additive genetic variance as roughly constant and independent of population size. In contrast, Kimura's neutral theory is based on an explicit model of mutation and drift, which leads to the prediction that the equilibrium genetic variance depends on population size while the rate of evolution is independent of population size. Although Lande (1976 p. 326) noted that the equilibrium level of additive variance will generally depend on population size, this was not incorporated into his test for neutral phenotypic evolution. Subsequently, Lande (1979, 1980) gave explicit formulas for the dynamics of phenotypic means and both the equilibria and dynamics of genetic variances and covariances for multiple characters under mutation and drift. As discussed below, these later analyses, like Kimura's neutral theory, lead to the prediction that the longterm rate of neutral phenotypic evolution depends only on mutation parameters and is independent of population size. Lynch and Hill (1986) analyzed the implications of more general genetic assumptions for both the dynamics and equilibria ofa single polygenic character subject to mutation and genetic drift. The purpose of the present note is to clarify the relationships among these results and to emphasize the critical role played by time scales and initial conditions in determining the importance of population size to neutral phenotypic evolution.


One of the most popular textbooks on logic, La Logique ou l'art de penser (better known as the Port Royal Logic), was written by Antoine Arnauld and Pierre Nicole and it was first published in 1662...


We investigate the numerical solution of stable Sylvester equations via iterative schemes proposed for computing the sign function of a matrix. In particular, we discuss how the rational iterations for the matrix sign function can efficiently be adapted to the special structure implied by the Sylvester equation. For Sylvester equations with factored constant term as those arising in model reduction or image restoration, we derive an algorithm that computes the solution in factored form directly. We also suggest convergence criteria for the resulting iterations and compare the accuracy and performance of the resulting methods with existing Sylvester solvers. The algorithms proposed here are easy to parallelize. We report on the parallelization of those algorithms and demonstrate their high efficiency and scalability using experimental results obtained on a cluster of Intel Pentium Xeon processors.


Introduction; Sports medicine is a clinical subspecialty that deals with the examination, monitoring, diagnosis, treatment, and prevention of injuries that occur during sports events, training and physical activities in pre-hospital settings. Managing dramatic situations with minor and multiple injuries is a challenge that requires a quick approach to a dramatic event in managing minor and multiple injuries on the football field and in other sports in support of SHME at pre-hospital and hospital level.
Purpose of the paper. Providing emergency medical care at all basic stages of managing minor and multiple injuries on the football field and in other sports in order to implement BLS, ACLS, BTLS, PTLS, ATLS care measures reducing morbidity, disability, and mortality.
Material and methods. The research is of retrospective, descriptive, qualitative type. The material was taken from the archive of the Emergency Clinic of UCCK for the period January-December 2019. Only the sick or injured in sports matches were taken in the research; Age, gender, type of illness and injury and type of medical care, equipment available, and training and education.
Result. Sports injuries are very costly, and according to the pathology with diseases were 15 cases or 21.4 %, injuries were 55 cases or 78/6 %. Injured by age. The largest number of injured with injuries in the field of football sports the most affected age was the age of 21-25 years with 28 cases or 40.00%, over 25 years were 27 cases or 38.58% and with a smaller number were aged 15-20 years15 cases or 21.42%.
Discussion and conclusions. A very important factor in sports injuries is the provision of optimal medical care for footballers and other sports in head, neck, spine, chest, abdomen, and pelvis and limb injuries and with a joint communication with the cooperation of health care professionals in the selection of priority cases. Education of medical staff, nurses, paramedics with courses, use of medical equipment, BLS, ACLS, BTLS, PTLS, ATLS as well as standard procedures for providing and transporting medical care to the hospital.


In this paper we determine second-order linear recurrence sequences in Mordell-Weil groups of elliptic curves over number fields without complex multiplication having almost all primes as divisors. We also consider more general groups of Mordell-Weil type.


Peroral irradiation of tumors of the oral cavity has been practiced since the early 1900's (8). Its application was accepted because it allowed high doses to the tumor without heavy irradiation of the sensitive intervening tissues, particularly the vulnerable mandible. In late years the development of successful radium technics and the advent of megavoltage beams have reduced the indications for peroral treatment, and Paterson (10) has gone so far as to label the method "an historical relic." Because of the many successful results observed in our institution, however, its use has been continued, and in recent textbooks (4, 9) the method has been suggested in selected cases. Peroral irradiation avoids the discomfort and attendant hospitalization of a radium insertion, as well as the sequelae of external treatment. The present review was undertaken to establish the rate of local control and of complications, such as necrosis, in relation to the treatment technic. From the study, a better knowledge of case s...


Most humans are repeatedly infected with new strains of influenza throughout their lifetime even though protective neutralizing antibodies against the viral hemagglutinin (HA) are generated after both natural infection and vaccination. This observed lack of protection against variant strains is largely attributed to a process termed `antigenic drift', where accumulating mutations in HA quickly abrogate recognition by antibodies elicited by earlier strains. Consequently, current influenza vaccines must be updated frequently in an attempt to match the antigenic profiles of vaccine strains to those of circulating strains. However, the existing process of antigenic determination is imperfect: it fails to consider the effects of receptor binding avidity in the interpretation of hemagglutination inhibition (HAI) assays or the effects of pre-exposure history on how a novel virus is viewed antigenically by an altered immune system. Here, we designed a series of experiments to address these issues. First, we computationally modeled how variation in receptor binding avidity could affect the antigenic characterization of historic H3N2 strains and experimentally demonstrated that single point mutations in HA can skew HAI titers without actually affecting antibody binding. Additionally, using the same H3N2 system, we showed that a single amino acid mutation can significantly alter the immunodominance of the anti-HA antibody response. We then completed a series of studies to determine how immune history influences the specificity of antibody repertoires. In examining patient serology, we found that the specificity of the human antibody response against the 2009 pandemic H1N1 virus (pH1N1) was highly correlated with pre-exposure history to different seasonal H1N1 (sH1N1) strains during childhood. Using a ferret model, we demonstrate that the anti-pH1N1 antibody response can be shifted to highly conserved epitopes on HA when the animals were primed with sH1N1s that are otherwise antigenically distinct. Collectively, our studies demonstrate that accounting for receptor binding avidity and factors that alter antibody repertoires will improve influenza vaccination strategies in the future. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Cell & Molecular Biology First Advisor Scott E. Hensley Second Advisor Jeffrey M. Bergelson


This work describes and compares two alternative methods of analyzing dielectric-loaded cavities for measurement of intermodulation distortion in HTS films. One of them is based on assuming a specific type of HTS nonlinearities and developing theoretical equations based on them. The second is based on a numerical approach that can be applied to many types of nonlinearities. Both methods are shown to work on measured data of representative HTS films.


extraterritorial loyalties. He repeatedly emphasizes the diverse but common South Indian inheritance of all major Sri Lankan groups. Tambiah outlines several points in a possible solution to the conflict, but these are so nonpartisan as to be unpopular with both of the parties concerned. On the one hand, the Sinhalese government must be prepared to "secularize" and "liberalize" politics and to carry out a genuine devolution of powers as envisaged in the provincial and regional councils plan. The Tamils must, on the other hand, give up the unviable demand for a separate Eelam and acquire competence in the majority language as the most practicable for administration. In the larger arena, to encourage a redefinition of identities, the government should actively promote nonsectarian historiography. Given the current polarized and militarized situation, the specific mechanisms by which such a solution would be achieved remain untouched. De Silva's book constitutes a reference to be consulted on the subject of ethnic tensions in Sri Lanka. But to obtain a broader, more balanced, and more nuanced understanding it must be supplemented by others like Tambiah's. The latter work is highly recommended to those interested in contemporary South Asia and ethnic conflict in the third world.


The arrival of the digital economy era further promotes the development of media convergence. Traditional media and new media present cooperation modes different with that in the past. With the development pattern of global integration, the change of media ecology is more intense. The corresponding change is the training mode of media talents. Journalism specialty in private colleges and universities has been committed to the cultivation of high-quality application-oriented talents. In the era of Internet of everything, it is necessary to seize the opportunity of industrial change, give full play to the advantages of education and teaching of subject platform, and integrate the media development concept of media convergence with the application-oriented cultivation of discipline construction, so as to make the undergraduate journalism education in private colleges and universities more advantageous and energetic.


The view about stochastic of Polanyi is based on his personal knowledge. The try to recognize the course of stochastic that is based on finite set is illegal. Stochastic is an active course, and probability computing can't join in the field of inarticulate knowledge, so we can't make the unity of recognization and existence.


Measurements of the electrical conductivity and the Seebeck effect in (V0.3Nb0.3)O2 are reported. A semiconductor‐to‐metal transition is observed at about 1000°K and an evaluation of the activation energy for the electron mobility gives 0.05 eV.


Objective To analyze retrospectively the effect of submental island flap on repairing tissue defects after oral cancer ablation.Methods 23 cases undergoing oral cancer ablation were treated by submental island flap simultaneously to repair the tissue defects.Results The success rate was 91.3%,achieving normal appearance and function basically.Conclusion Submental island flap is feasible for repairing small or middle sized tissue defects after oral cancer ablation,with simple operation,high success rate,and less damage to patients.


225 Of the thousands of artists who exhibited drawings (including pastels and watercolors) in Paris between 1860 and 1890, art historians would be challenged today to recognize the names of even 5% of this number. Moreover, in many of these exhibitions, frustratingly few items can be identified with surviving works. It is thus hoped that by using a data-driven methodology to analyze the printed catalogues of state-sponsored exhibitions and those organized by artists' societies and dealers during that period, we can begin to formulate a more complete picture of the artists then active, and of the kind of drawings they produced. Data-driven art history––using the latest technological tools to compile and analyze printed records––represents one of the newest approaches in the field, part of an emerging collaborative approach to scholarship in the humanities and one that is able to elucidate long-term trends and to identify patterns. Besides providing insights into shifting taste and calling attention to the success of numerous artists who are nowadays completely unknown or very little studied, this article's findings suggest that one motivator for the growing interest in drawings in late nineteenth-century Paris was arguably the competitive spirit the French held toward the British.


Objective To establish a simple but practical experiment method or procedure for primary culture of choroid plexus epithelial cells(CPECs) from rats so as to be used for further in vitro experiments. Methods CPECs were dissociated mechanically from neonatal Sprague-Dawley rats(1-9 days old),and cultured in DMEM nutrient with 100 mL/L fetal calf serum in water-saturated environment of 50 mL/L CO2 at 37 ℃.The morphological changes of cultured CPECs were observed.Hematoxylin and eosin(HE) staining,electron microscopy,and immunocytochemical technique were used for CPECs identification on day 9 of culture;the purity of positive cells was calculated. Results The cultured CPECs showed fusiform or multipolar morphology,or frequently clustered in irregular folds or were covered with irregular and numerous microvilli observed under electron microscope.Over 95% of the cultured cells were identified as CPECs or TTR-positive cells. Conclusion CPEC with high purity has been obtained in vitro from neonatal rats by mechanical dissociation without enzyme digestion,which is a simple and inexpensive way of primary cell culture.


The lifting scheme is an efficient and flexible method for the construction of linear and nonlinear wavelet transforms. In the nonlinear lifting scheme, it is difficult to design the optimal update filter corresponding to the nonlinear prediction filter. It is well-known that the combination use of linear filter and nonlinear filter is an efficient filter pair. In this paper, we propose a novel lifting-based lossless image coding method using discrete-time cellular neural networks (DT-CNNs). In our method, the image is interpolated by using the nonlinear interpolative dynamics of DT-CNNs, and the linear 5-tap filter is used for avoiding the aliasing. Since the output function of DT-CNNs works as a multi-level quantizing function, our method composes the integer lifting scheme for lossless image coding. Moreover, our method makes good use of the nonlinear interpolative dynamics by A-template compared with conventional CNN image coding methods using only B-template. The experimental results show a better coding performance compared with the conventional lifting methods.


. The virtual world today rejects the needs for children to explore and be active with outdoor spaces. These lead to children's poor mental, physical and social growth development. To justify and understand the outdoor needs of early childhood development , it is essential to address and enhance the significance of outdoor landscape elements. Therefore, this study aims to explore children's preferred outdoor landscape elements in their early education stage. The study used pictorial techniques, interview and behaviour observation towards the children aged 5 to 6 years old from selected preschools at Seri Iskandar Perak. The results indicate that the play structure elements in outdoor spaces are the most preferred for childhood education.


Objective To study the relationships between Bone mineral density(BMD) and serum levels of bone metabolism index including Tartrate-resistant acid phosphatase( TRACP),Collagen type Ⅰ carboxy-terminal peptide(CTX-1),Bone alkaline phosphotase(BALP),Calcitonin(CT),Bone Gla protein(BGP),Paratyroid hormone(PTH) and 25(OH) Vitamin D3 (25(OH) D3 ). Methods BMD at the one-third of distal Radius and ulna of non-dominant forearm was measured using DTX-200 detector made by American Osteometer Medi Tech Corporation; The bone metabolism index were measured by full-auto chemiluminescence analyzer(USA Beckmancoulter) and full-auto micro plate eia analyzer (USA Thermo). The 791 persons was didived into several groups by every five years. and then applied sofware SPSS 13. 0 to statistics data. Results The bone metabolism index such as TRACP,CTX-1,BALP,BGP were not statistically significant at gender among the age groups from 35 to 49 years old,but did among the age groups from 50 to 79 years old and the data of them in female was higher than them in male. The measure values of TRACP and CTX-1 were negative correlated with BMD;The measure values of BALP,BGP at the age groups from 50 to 64 yaers old was increased in female and were negative correlated with BMD,however,the measure values of them were decreased from 65 years old. The measure values of 25(OH)D3 was positive correlated with BMD;The measure values of CT was decreased in the age groups from 65 to 79 years old,and was positive correlated with BMD. Conclusion The test of bone metabolism index provided a significant technical method for monitoring bone mass and the earlier diagnosis of osteoporosis.


A multidisciplinary conference audience was enthralled recently by a doctor's account of how she had met her performance targets, increased throughput, enhanced clinical outcomes, improved satisfaction and managed to get home on time. She had achieved this simply by taking the advice of the specialist nursing staff in her unit on how to run the service and then left them to do what they do best.


Self‐organized vegetation patterns are efficient rainfall harvesting systems, where runoff flow paths are highly dis‐connected. Runoff is generated over bare, crusted areas and diverted toward vegetated patches with higher infiltration capacity. The ecosystem structure is the result of scarce rainfall, local facilitation and adaptation of vegetation. An ecological model for the dynamics of two plant species and soil water content is used here as an instrument to investigate the hypothesis that ecological connectivity of adaptation niches could upscale to hydrological dis‐connectivity, with positive feedback on water use efficiency.


We discuss implications of improved upper bounds on the |∆L| = 2 processes (i) K+ → π−μ+μ+, from an experiment at BNL, and (ii) μ → e+ conversion, from an experiment at PSI. In particular, we address the issue of constraints on neutrino masses and mixing, and on supersymmetric models with R-parity violation. 13.20Eb,14.60Pq,14.60St,14.80Ly Typeset using REVTEX email: firstname.lastname@example.com email: email@example.com, on sabbatical leave from Yang Institute for Theoretical Physics, State University of New York, Stony Brook


Electrophoretic deposition was used to produce titanium dioxide (TiO2) nanostructured films on copper substrate in aqueous media for photocatalytic application. Polyvinyl pyrrolidone (PVP) with a weight rate from 0 to 15% was added to TiO2 P25 suspension in order to enhance film adhesion. The films were characterized by X-ray diffraction, optical microscopy, contact angle measurement, nanoindentation, scratch test and photoluminescence. The photocatalytic activity of the films was tested with amido black 10B under UV irradiation. The results indicated that the morphology and the mechanical properties of films depended on the added PVP amount. Scratch test showed that adhesion strength rose with increased PVP amount. The photocatalytic activity indicated that TiO2 film synthesized with 13% PVP had the highest efficiency.


Pyrrole (C4H5N) was embedded in low-temperature solid inert matrixes (argon, xenon; T ) 9 K) and both the monomer and low-order aggregates characterized by FTIR spectroscopy. The spectroscopic studies were complemented by extensive theoretical [DFT(B3LYP)/6-311++G(d,p)] structural and vibrational studies carried out for the monomer and their self-aggregates (up to four units). The calculated spectrum for monomeric pyrrole fits well those obtained immediately after deposition (at 9 K) of diluted matrixes, which can be prepared keeping the compound at low temperature before deposition and using low fluxes of the sublimate. Annealing of the matrixes to higher temperatures or increasing of the gaseous flux during deposition leads to aggregation, which can be easily recognized spectroscopically. On the basis of the theoretically predicted spectra for the monomer, dimer, trimers, and tetramers of pyrrole, assignments were proposed for the experimentally observed bands. It was also found that the formation of the hydrogen-bonded clusters shows a significant cooperativity effect, which was studied in detail and could be related with several structural and spectroscopic parameters. Infrared spectra of the pure solid compound at low temperatures in both amorphous and crystalline states were also studied and interpreted.


This paper analyses and researches the relationship between period fixed cost and operating leverage, and gives some new results which from the quantitative analysis.


This study provides information on the community of birds that live in the La Cueva in the PNN Munchique, municipality of El Tambo, Cauca. An assessment is made of the community and a comparison of the diversity and composition of the birds in the monitoring made during 2015, 2016 and 2017 in the study
area. Through captures and observations, we register 186 species belonging to 40 families and 16 orders. The diversity of bird species according to the Shannon- Wiener index was 4.7 units. The year that presented the major richness and diversity was 2015, but this result is highly influenced by the sampling effort. La Cueva can be considered as an area rich in bird species and is characterized by presenting species of the Selva Subandina of the Pacifica
Caucana region, mainly those typical of forest habitats as species of the family Trochilidae, Thraupidae and Furnariidae.

key words: Birds, Comunity, El Tambo.


As a result of the requirements to shorten the development cycle of new engines, CAE techniques become increasingly important in the early design stages. More specifically, the complex task of vibro-acoustic optimisation, traditionally an end-of-cycle task, is now shifting towards the pre-assembly phase. Structural and acoustic modelling methods, used to predict the performance in terms of noise, vibration, engine dynamics and durability, rapidly evolve to being key tools in the design processes. Traditional CAE analyses of powertrains rely on large-scale FE-models, describing the engine, transmission and auxiliaries in much detail, and lead to high model development times and high computational times. However, because of the limitations currently put on the total design cycle duration, modelling methods need to be able to handle a mixture of pure analytical design models and experimentally obtained dynamic characteristics. Based on analytical vibro-acoustic component models, an initial predictive assembly model is built. Excitation forces resulting from dynamic simulation or from experimental identification on existing engines are used to load the model for the evaluation of the performance or design changes in terms of absolute noise and vibration levels. The noise and vibration quality can thus be evaluated at assembly level and next cascaded down to requirements at component level. Whenever available in a new development phase, the measured dynamic characteristics of prototyped components are integrated into the total model, to refine the virtual prototype of the assembled product (see Figure 1). This paper covers the investigative application of these hybrid vibroacoustic simulation techniques. The described project has been executed as under cooperation between Toyota Motor Corporation and LMS Engineering Services in order to establish the above process and validate the simulation techniques. The Toyota 3S-FE engine is used as a benchmark engine throughout this paper.


The PSC has developed a prototype distributed file system infrastructure that vastly accelerates aggregated write bandwidth on large compute platforms. Write bandwidth, more than read bandwidth, is the dominant bottleneck in HPC I/O scenarios due to writing checkpoint data, visualization data and post-processing (multi-stage) data. We have prototyped a scalable solution that will be directly applicable to future petascale compute platforms having of order 10^6 cores. Our design emphasizes high-efficiency scalability, low-cost commodity components, lightweight software layers, end-to-end parallelism, client-side caching and software parity, and a unique model of load-balancing outgoing I/O onto high-speed intermediate storage followed by asynchronous reconstruction to a 3rd-party parallel file system.


ABSTRACT How offenders cease offending and engage in the desistance process is a key consideration for effective rehabilitation. While attention is increasing on desistance and its utility in the supervision and case management of offenders postrelease, it's yet to be integral to postrelease programs. This paper considers the implications of the desistance process for psychological postrelease programs, such as community maintenance programs. There will be a brief review of some of the theories of desistance, consideration of the interrelationship between desistance theory and community maintenance programs and discussion about the implications of desistance theory for the delivery of community maintenance programs.


Lung cancer is a type of cancer that spreads rapidly and is the leading cause of mortality globally. The Computer-Aided Detection (CAD) system for automatic lung cancer detection has a significant influence on human survival. In this article, we report the summary of relevant literature on CAD systems for lung cancer detection. The CAD system includes preprocessing techniques, segmentation, lung nodule detection, and false-positive reduction with feature extraction. In evaluating some of the work on this topic, we used a search of selected literature, the dataset used for method validation, the number of cases, the image size, several techniques in nodule detection, feature extraction, sensitivity, and false-positive rates. The best performance CAD systems of our analysis results show the sensitivity value is high with low false positives and other parameters for lung nodule detection. Furthermore, it also uses a large dataset, so the further systems have improved accuracy and precision in detection. CNN is the best lung nodule detection method and need to develop, it is preferable because this method has witnessed various growth in recent years and has yielded impressive outcomes. We hope this article will help professional researchers and radiologists in developing CAD systems for lung cancer detection.


Objective To discuss the clinical effects of nursing intervention on 131I treatment of Graves Disease combined with mental disorders.Methods 76 patients were diagnosed with Graves disease combined with mental disorders at our hospital and treated with 131I. The patients were randomly divided into two groups: 36 cases in the control group, routinely informed with notes before and after 131I treatment, and 40 cases in the intervention group, with nursing interventions before and after 131I treatment. SF-36 health scale was used before and after the intervention to measure quality of life. Patient satisfaction, knowledge on the radiological protection and the proper method of taking medicine, and recovery of mental disorders were compared between the two groups.Results The intervention group had higher level of patient satisfaction than the control group[100.00% vs 88.90%,χ2=47.56, P .05). Among patients with obvious advancement, the intervention group exhibited better treatment effect than the control group. The difference was statistically significant.Conclusions Nursing intervention has important clinical significance in 131I treatment of Graves disease combined with mental disorders.

Key words:
Iodine radioisotopes; Graves disease; Mental disorders; Nursing intervention