The optical property of the ball lens mounted hollow optical fiber Raman probe (BHRP) is studied in the present study. Since the ball lens has rather large aberration, the focus of the BHRP is dispersed and the spatial resolution in depth direction goes low. The spatial dispersion of the focal point was evaluated using model samples. The BHRP equipped a sapphire ball lens of 500 μm diameter was employed. Layered samples consisting of a polymethyl methacrylate (PMMA) substrate and various thicknesses of polyethylene (PE) films were measured with the BHRP. The relative band intensities of the upper and the lower layers appear at different rates in the obtained spectra, reflecting the optical properties of the probe. According to the spectra, the optical dispersion of the focal point is estimated. The result suggests that the spatial dispersion of the focus point fitted to Gaussian distribution. The working distance (WD) is 53 μm and the FWHM of the fitted Gauss distribution is 64 μm.


Climate change is internationally recognized as a source of concern by governments, scientists and public opinion. In this context, the need to find concrete solutions becomes increasingly urgent. Numerous economic sectors contribute to alteration of climate, especially livestock and, more generally, food production-related activities. For this reason, animal welfare policies, the complex of norms and regulations adopted by single Member States and the European Union in the field of meat production, could be a useful instrument in the climate transition invoked by policy makers and scientists. The aim of this paper was to analyze the current system of animal welfare from a legal and veterinary perspective, and to demonstrate how important and useful, it could be in the fight against climate change; at least if correctly implemented and applied.


The core component of the direct evaporative cooler is the filler,and its performance have a direct impact on the efficiency of the heat exchanger.At present,there are several fillers in common use,for example,inorganic filler(such as Munters'GLASdek),organic filler(such as Munters'CELdek) and aluminum foil filler.Although a large number of scholars have focused on the heat and mass transfer process on the surface of all above fillers and its properties,no one have done the comparative experiment of all these fillers in the same conditions.In these experiments,we take five fillers to study their performance in almost the same conditions,such as GLASdek,CELdek,aluminum foil,the porous ceramic filler used in cooling towers,and the blue PVC fill offered by a domestic company.And there availabe some conclusions in order to provide guidance for engineering application.The results show that all fillers have their own advantages and disadvantages and we must choose it according to the specific situation.The efficiency of the porous ceramic is significant and can be used as the filler in direct evaporative coolers.


The thermal coefficient α (=d V/d T) of the redox potential (V) is an important physical parameter for thermal energy harvesting. To clarify the microscopic origin of α in conjugated polymers, we compared α and the physical quantity obtained by a quantum chemistry calculation in typical polymers with small monomer molecular weight. We observed a strong correlation between α and the number (N active) of the active atom, which is defined as the atom whose variation of the Mulliken charge (Δq) at the oxidation process is beyond a threshold (Δq th). We interpreted the material dependence of α in terms of N active, because active atoms have a significant effect on the configuration entropy of the surrounding solvent molecules.


Several homoleptic and bis-heteroleptic tris-ligated polypyridine complexes of Ru(II) have been prepared in the zeolite Y supercages. Ru(L)[sub n](L[prime])[sub 3[minus]n]-Y (where n = 0, 1, 2, 3 and L, L[prime] = bpy, dmb, mmb, and bpz) complexes have been investigated by electronic absorption, electronic emission, resonance Raman, and time-resolved resonance Raman spectroscopies. Excited-state lifetimes of the entrapped complexes have been measured and their temperature dependence established. While entrapment of the complexes in the zeolite matrix introduces no major modifications in structure or electron distribution, it does induce changes in the efficiency of various excited state energy dissipation pathways, the major effect being an increase in the energy of the metal-centered dd excited states which leads to elimination of one of the major decay and decomposition pathways. 33 refs., 6 figs., 3 tabs.


A Service Level Agreement (SLA) is a business operations concept that is sometimes inappropriately applied to engineering development. When an SLA is not converted to engineering requirements, development occurs blindly, and testing is probably done against some of the values specified in the SLA. The result is higher risk and higher cost. This paper illustrates some fundamental aspects of the testing interval that are relevant to the evaluation of the SLA by examining a real example.


Consumer price index (CPI) prediction is an effective approach to measure inflation and provide a reference to formulate economic development strategy. The Autoregressive Integrated Moving Average (ARIMA) model is a classic model to predict CPI. However, a main drawback of ARIMA model is that it only utilizes the time effect while ignoring inter-regional economic interaction which is another significant effect on CPI. Aiming at this, the Generalized Space Time Autoregressive Integrated (GSTARI) model is proposed. In this paper, we verify and compare the prediction accuracy of both GSTARI model and classic ARIMA model with the CPI data of 4 main cities (Dalian, Shenyang, Changchun and Harbin) in China. Our experiments show that for most of cities, GSTARI model have 7%-38% higher prediction accuracy than ARIMA model.


Depended on the statistics from 1994 to 2006 about economy and Population culture quality in china,chose the Per-capita GDP and the percentage of different educational population as the index of evaluation about economy and Population culture quality.The analysis of correlation indicated that the relativity between economy and Population culture quality is very positive.Aimed at the results of the analysis of correlation,found out the new model which is the best fit for the relation between economy(x)and Population culture quality(y).The new model was tested and verified using the spatio-temporal data on the economy and Population culture quality of China,the model could be written as.So,an important conclution can be described that in the course of economy,the Population culture quality must be reasonably enhanced,because the economy and the people's cultural quality can be influenced by each other.


We all know that electronic prescriptions solved all those script communication problems between prescribers and pharmacists, right? Well, the Cynical Pharmacist dispelled any such myths in his blog "Electronic prescriptions: Return to sender." It was our most-read story of June.


Evaluation of chemical residue dissipation and transport under actual use conditions is an important aspect of risk assessment for many chemical compounds. The potential mobility, dissipation, and degradation of contaminants and their degradation products under actual field use conditions can be assessed in several ways. This paper presents a recently developed lysimeter design that has an intact soil core, runoff, and leachate collection systems, that are easy to assemble and install in the field and are self-contained. Use of radiolabeled test chemical provided an opportunity to study the decline of a test chemical and formation and decline of its degradation products and accountability of the test chemical under in situ field conditions. Successful field validation was completed during 1994 in North Carolina. An eight column (6 inch x 36 inch) 90 day study was conducted in a sandy loam soil. Use of radiolabeled material allowed monitoring of the test chemical and its degradates throughout the 36 inch test zone. The success off the lysimeter lies in the modularity of its design having three component systems: runoff collection, leachate collection, and the intact soil core component. When properly used, the lysimeter is capable of generating data to assess the potential fatemore » and mobility of chemicals in situ. Further analysis will concentrate on the feasibility of using the lysimeter design to develop, calibrate, or validate transport models. Additional research using different soil types and chemicals under varying climatological conditions is needed to develop a better understanding of these systems.« less


The forecast and analysis of the trend of the RMB exchange rate have been deeply explored by many researchers in the financial field, but the combination of public opinion sentiment data and historical market data to forecast the RMB exchange rate in the short term has been studied little. With the rapid development of the Internet, the influence of public opinion sentiment on the economy and society is increasing. Online public opinion sentiment data not only have an impact on stock prices [1] and commodity prices, but also have a significant impact on foreign exchange (Forex) rates. However, the public opinion data are not applied for the RMB exchange rate forecast, because the impact of public events on the exchange rate is ignored. Besides, the lack of exact temporal sliding window of public opinion ignores its timeliness and sensibility.


Abstract The phenylethanoids rostkovianoside, 6′-O-acetylcrassifolioside and the flavonoid rutin 3‴-acetate, were isolated from the methanolic extract of the aerial parts of Euphrasia rostkoviana Hayne. The structures of these previously undescribed compounds were elucidated by interpretation of spectroscopic data. The acetylation of rutin was also carried out and four ester derivatives were spectroscopically characterized. Finally, a chromatographic method was established to easily identify the acetylated position. Graphical Abstract


ASCHOFF, J., AND H. POHL. 1970. Der Ruheumsatz von Vogeln als Funktion der Tagezeit und der Korpergriisse. J. Omithol. 111:3847. CHAPLIN, S. B. 1974. Daily energetics of the Black-capped Chickadee, Parus atricapillus, in winter. J. Comp. Physiol. 89:321-330. CHAPLIN, S. B. 1976. The physiology of hypothermia in the Black-capped Chickadee, Parus atricapillus. J. Comp. Physiol. 112:335-344. DAWSON, W. R., AND J. R. HUDSON. 1970. Birds, p. 223-310. In G. C. Whittow [ed.], Comparative physiology of thermoregulation. Vol. 1. Invertebrate and nonmammalian vertebrates. Academic Press, New York. FEDUCCIA, A. 1977. A model for the evolution of perching birds. Syst. Zool. 26:19-31. FOSTER, M. S. 1977. Ecological and nutritional effects of food scarcity on a tropical frugivorous bird and its food source. Ecology 58:73-85. HUDSON, J, W., AND S. L. KIMZEY. 1966. Temperature regulation and metabolic rhythm in


1. Alternatively see his paper, 'A Preliminary Model of Particularistic Tics in Chinese Political Alliances: Kan-ch'ing and Kuan-hsi in a Rural Taiwanese Township', The China Quarterly, no. 78 (1979), pp in 7-73. 2. See Bernard Galiin, 'Political Factionalism and Its Impact on Chinese Social Organization in Taiwan' in Marc J. Swartz (ed.), Local-Level Politics: Social and Cultural Perspctives, University of Londoan, London, 1969, pp. 377-400. 3. See also 'The Cultural Bases of Factional Aligment and Division in a Rural Chinese To vnship', The Journal of Asian Studies, vol. xxxvi, no. 1 (1976), pp. 79-97. 4. 'Marketing and Social Structure in Rural China', The Journal of Asian Studies, vol. xxiv, nos. 1-3 (196465), pp. 4-43. 5. 'China's Cellular Economy: Some Economic Trends Since the Cultural Revolution', The China Quarterly, no. 52 (1972), pp. 605-19.


ASH A SCHEDULER FOR HOAs By Qian Li The resource constrained scheduling problem is a basic problem in computer science research, supply chain management research, and operations research. My project focuses on developing job scheduler, Super-ASH, capable of aiding homeowner associations in achieving an efficient schedule for repair jobs. The goal is not only to have customers' requests fulfilled in a timely manner, but also to give immediate feedback of a timeframe in which activities jobs will be completed. Moreover, job scheduler enables homeowner associations to set up their own configurations, allowing them to set the job type table, define the scheduling queue model, and change the interval and amounts of the incoming budget based on their own real conditions. The two basic scheduling objectives we seek to optimize are to minimize the (actual) average flow time, and to minimize the (actual) average stretch. To achieve these goals, we considered the advantages and drawbacks of a multi-level-queue scheduling algorithm, the simplicity of First In First Out (FIFO) and Shortest Processing Time First (SPTF), and the semiclairvoyant R algorithm. From considering these, we developed our Super-ASH scheduler. In this report, the detailed design and implementation of a Super-ASH scheduler is described. Also the different test cases and results will be investigated in various ways to yield good scheduling performance.


The second book of a trilogy of novels known collectively as "The Rosy Crucifixion". It is autobiographical and tells the story of the early days of Miller's turbulent second marriage, his impoverished life in New York and his first steps towards being a writer.


Recommends a new-type heating, ventilation, air conditioner equipment using in large space. According to its unique way of blowing, analyses the operation offect of the new-type equipment. The economic performance is compared with the air conditioner system using the duct blowing. Looks forward to the equipment application in large space finally.


The US Department of Energy (DOE) is initiating tests of reactor fuel for use in an Advanced Gas Reactor (AGR). The AGR will use helium coolant, a low-power-density graphite-moderated core, and coated-particle fuel. A series of eight (8) fuel irradiation tests are planned for the Idaho National Laboratory's (INL's) Advanced Test Reactor (ATR). One important measure of fuel performance in these tests is quantification of the fission gas releases over the nominal 2-year duration of each irradiation experiment. This test objective will be met using the AGR Fission Product Monitoring System (FPMS) which includes seven (7) online detection stations viewing each of the six test capsule effluent lines (plus one spare). Each station incorporates both a heavily-shielded high-purity germanium (HPGe) gamma-ray spectrometer for quantification of the isotopic releases, and a NaI(T1) scintillation detector to monitor the total count rate and identify the timing of the releases. The AGR-1 experiment will begin irradiation in December 2006. To support this experiment, the FPMS has been completely assembled, tested, and calibrated in a laboratory at the INL, and then reassembled in its final location in the ATR reactor basement. This paper presents the details of the equipment performance, the control and acquisition software, the installation in the ATR basement, and the test monitoring plan.


Ever since Internet of Things (IoT) has become a reality, fresh challenges have been propping up in a day-to-day manner for keeping the paradigm robust. As an IoT enabling technology, Low Power Lossy Networks (LLNs) play a notable role in ensuring the connectivity of devices, and thereby the efficient functioning of applications. Considering their resource constrained nature, routing protocols designed for LLNs demand a proper management of vital resources. The paper considers node memory, node battery, and network bandwidth to be vital network resources, and reviews in detail the existing LLN routing protocols as well as routing metrics with respect to the level of resource management achieved by each of them. Finally, the paper enlists research challenges in the field of LLN routing, which can be considered as the need of the hour, for assisting the IoT paradigm to reach its maximum potential.


The survival and development of the teaching journals requires editors to have high cultural and editorial professionalism,editorial team to cooperate with vitality.The contents of teaching journals should go close to teaching,with explicit feature and distinctive personality.Such Journals serve as a source,paying attention to and participating in teaching and research,developing,cultivating and improving the authors and thus shaping the publication.


Abstract : The research is presented in three parts. (1) Filtration of Aluminum Alloys - The effectiveness of various filter media in removing oxide particles and synthetic inclusions such as TiB2 from aluminum alloys was investigated. Results showed that by proper choice of filters, particles of different sizes can be effectively filtered from aluminum alloys. Pressures required for metal flow through the smallest pore filters were less than 60 psi. (2) Specific Permeability of Partially Solidified Dendritic Networks of Al-Si Alloys - Segregated interdendritic liquid was successfully removed from partially solidified Al-Si alloys. Porous columnar, equiaxed and grain refined dendritic networks of the alloys were prepared. Specific permeabilities of the porous dendritic networks were measured using a triaxial cell permeameter. For equivalent volume fraction solid, the permeabilities of the grain refined samples were found to be lower than those of the non-grain refined samples. Flow through the partially solid non-grain refined samples obeyed D'Arcy's law. (3) Casting of Aluminum Alloy - Particulate Ceramic Composites - A new process for the preparation and casting of metal-ceramic composites is described. Particulate composite end chill plates containing Al2O3, SiC or glass beads in an Al-Si-Fe alloy matrix were successfully prepared. These plates exhibited good abrasion resistance and improved hardness. (Author)


Logo is widely used in all aspects of modern society,it becomes increasingly important role in today's highly developed information society.The key of making logo design successful is that "how to combine the cultural connotation and logo design perfectly,then design the modern logo with nationality,times and international features".To well grasp the cultural connotation in logo design can bear the time test to keep indefinitely.


Most metropolitan regions advocate cooperation among municipalities and bewteen public and private actors to plan and fund new housing and transportation infrastructure. Just as many experience frustration that such cooperative structures fail to materialize or prove ineffective. A recent study of several municipalities north of Stockholm, Sweden investigated what hinders and opportunities may exist to improve the potential for cooperation and collective action in infrastructure provision. This included a special focus on the challenges of polycentric spatial development that presents a classic social dilemma with uneven payoffs and costs for individual communities. The study includes three cases focused on retail centres, transportation corridors and new housing.


Immigrant family businesses are one of the most unique, complex and dynamic systems in our modern-day society. The blending of two inherently different realms — the performance-based world of business and the emotion-based domain of the immigrant family — creates a system potentially fraught with confusion and conflict. Applying traditional, limited and exclusively Western views of entrepreneurship to immigrant family business creation, growth and sustainability is to ignore or discount the core cultural/ethical values and ethnic contexts in which these firms operate. The objective of this conceptual paper is to identify and explore the three variables of enterprise, ethnicity and family dynamics that influence corporate governance to ensure the survival, growth and sustainability of immigrant family businesses. Conclusions and recommendations for future research are discussed.


Dynamics of primary disability in the Volgograd region within the period of 2007 2012 is presented in the paper. Intensive and structural disability indices as well as allocation according to disability cause are discussed. Comparative characteristics of primary disability levels are implemented.


A new method and apparatus are described for the determination of concentration in liquid mixtures through the measurement of their thermal effusivity. The inverse photopyroelectric method (IPPE) implies the front illumination of a thin pyroelectric sensor the rear side of which is brought into the intimate thermal contact with the sample. The feasibility of this novel technique is demonstrated with ethanol-water mixtures. Good agreement between the experiment and theory has been obtained.


It is a key tool for reducing distribution network failure loss by identifying the fault cause promptly and correctly and eliminating the fault quickly. By examining whether the Q and T2 statistics exceed the control limit, the fault diagnostic method based on Principal Component Analysis (PCA) may determine whether a fault occurs and the source of the fault by using the contribution value of Q and $\mathbf{T}^{2}$. However, the outcome of this procedure is ambiguous, resulting in low diagnostic accuracy. To simplify diagnosis chores and enhance diagnosis accuracy, this research suggested a PCA fault diagnosis approach based on Compound Statistics of Residual and Score (CRS), which uses Q and T2 Statistics to produce CRS Statistics and CRS contribution value. Finally, an IEEE33 node distribution network model is created for simulation verification, and the results validate the PCA approach for defect identification based on CRS data.


In recent years the number of cabbage worm Pieris rapae has increased in Beni Suef Governorate, and they have threatened the vegetative growth of cabbage crop, especially in the newly reclaimed areas. That study was conducted during the 2017/18 – 2018/19 seasons respectively. Results obtained revealed that there are two distinct peaks for each eggs, larvae and pupae stages per year on cabbage plants. The immature stages covered the entire period of sampling from August 2017, till April 2018 on the cabbage plant. The first peak of egg Population was recorded on November 6 2017 and another smaller peak on mid of March 2018. The maximum larval Population (770 larvae) appeared on November 13, 2017 another smaller peak (450 larvae) on beginning April 2018. Pupal population exerted two periods of abundance On the 22 November, 2017 the highest numbers of pupae were recorded and another smaller peak on mid-April 2018. We can point out that the first and second peak of these stages in 2018/19 came about one to two weeks after the previous season 2017/18. The results also showed that there were statistically significant differences between the number of immature stages and the seasons of the year in cabbage fields. The cabbage sown in autumn season was severely attacked by this pest, followed by spring season. Autumn insect population was about 2-3 folds of winter population. Knowledge of the seasonal abundance of the immature stages is of great valuable to help in planning a control program against this target pest.


Inspection and maintenance are extremely important to maintain safety and long-term usability of bridges. This application requires a robot that is able to maneuver in a complex 3D environment and to stabilize on steel surfaces to perform bolts checking. We propose a novel design and concept of hybrid (integrated walkability and flyability) robot for steel bridge inspection and maintenance. Our proposed design allow the robot to access a 3D structure without being time consuming. In order to stabilize our robot in 3D space, we present a vibration control based on a vibrator to compensate vibration generated from joint actuators when the robot is flying. We present a preliminary experiment on how our robot performs obstacle avoidance along with a simulation of flying performance of a hybrid robot when the vibration was compensated based on LQG control.


Honeywell applied the rigorous and well‐documented Six Sigma quality‐improvement approach to the complex, highly heterogeneous, and mission‐critical process of remedial site environmental data management to achieve a sea change in terms of data quality, environmental risk reduction, and overall process cost reduction. The primary focus was to apply both qualitative and quantitative Six Sigma methods to improve electronic management of analytical laboratory data generated for environmental remediation and long‐term monitoring programs. The process includes electronic data delivery, data QA/QC checking, data verification, data validation, database administration, regulatory agency reporting and linkage to spatial information, and real‐time geographical information systems. Results of the analysis identified that automated, centralized web‐based software tools delivered through Software as a Service (SaaS) model are optimal to improve the process resulting in cost reductions, while simultaneously improving data quality and long‐term data usability and perseverance. A pilot project was completed that quantified cycle time and cost improvements of 50% and 65%, respectively.


LBL-38320 UC-1600 ERNEST DRLANDO LAWRENCE BERKELEY NATIONAL LABORATORY Thermal Performance of Phase Change Wallboard for Residential Cooling Application Helmut E. Feustel and Corina Stetiu Environmental Energy Technologies Division April 1997


We show that dynamic magnetization at the lateral edges of a thin, axially magnetized magnetic element with finite in-plane size can be described by effective ''pinning'' boundary conditions. This effective pinning is of a purely dipolar nature, is not related to the magnetocrystalline surface anisotropy of the magnetic material, and is determined by the inhomogeneity of the dynamic demagnetizing field near the edges of the element. Eigenfunctions and eigenvalues obtained using these effective boundary conditions give quantitative description of the quantized spin wave spectra experimentally observed in long and thin permalloy stripes of a micron-size width.


Most Chinese scholars base their researches in International Relations Theory (IRT) on modernity, in which the West has already secured an unshakable hegemonic position. Ever since the 1960's, the post-modernity, with its multi-originality and multi-element characteristics, has come to the forefront; and it has positive significance for the innovation of IRT. After failures in efforts of several decades to establish the Chinese school of IRT, the Chinese scholars might divert their endeavors to the post-modernity direction in their exploration to construct the Chinese School of IRT.


Energies associated with deviations from stoichiometry for an extensive series of A2B2O7 pyrochlores have been predicted. A3+ cations range in size from Lu to La and B4+ cations from Ti to Pb. Results are presented in the form of contour maps as a means of conveying large quantities of data as well as predicting characteristics for pyrochlore compounds not explicitly modeled. These contour maps indicate that the BO2 excess nonstoichiometry in the pyrochlore structure is distinct from solid-solution fluorite. Within the limitations of this methodology, the contour maps provide a means to understand and predict distinct compositional variations. Defect cluster formation is discussed.


, Believing that women in general are not given the health care they deserve, a group of women activists, after a meeting in Bangalore in 1987, went ahead and organised a programme called Shodhini (woman researcher) in different parts of rural and tribal India. They organised meetings to enable the women to know how their bodies function, how to take care of themselves by checking for early signs and symptoms of ill health, what to do in circumstances when neither organised health


AC machines supplied in parallel by a common voltage source inverter are sometimes used in industrial applications. This reduction of power electronics leads to a reduction of cost, weight and dimensions that is very useful for on-board systems. In such applications, a master-slave control is generally used: only one machine is really controlled. But if a disturbance occurs on the slave machines, it can not be taken into account. In this paper, another control strategy is suggested by weighting the control of each machine. Experimental results show the improvement of this control strategy


One embodiment relates to the sequence of the solar cell modules arranged for transport (900). Sequence was provided with a plurality of solar cell modules (902), each solar cell module includes a frame (602) having at least an upper member and (608) and the lower member (604). Multiple alignment structure (506) is provided on the upper member (608) of each frame, a plurality of alignment structure (610) is provided in the lower member (604) of each frame. Adjacent solar modules are connected to each other by the alignment structure of the upper member of the module located on the lower side, and the alignment structure of the lower member of the module on the upper side. Other embodiments, features and aspects are disclosed. .FIELD 6


In this paper, the observability analysis of induction motor is studied. The aim is to clarify observability problems found in particular when the motor operates at low frequencies. From this study, a sensorless observer benchmark is defined for sensorless induction motor observers validation. An observer based on interconnected form to estimate the mechanical and magnetic states of sensorless induction motor is designed. Taking into account the parameter uncertainties of induction motor and based on Lyapunov theory, the proof of the observer convergence is given. The proposed observer is tested and validated on reference trajectories of our bench-mark.This benchmark is applied on an experimental set-up located at IRCCyN (Nantes, France). Robustness tests with respect to parameters variations show the applicability of the designed observer


Nowadays,structural lineament of Shanxi formation in Zizhou gas field is a large monocline of southwest descent.Its structural features are steeping in the northwest,gentling in the southeast and its nose-bulge scope is smaller.According to the core observation,electrofacies features and the study of sedimentary structure,it is considered that Shanxi formation of Zizhou gas field is continental sea-meandering fluvial deltaic deposit.The purpose of the study on sedimentary facies is to classify the beneficial phase belt in Zizhou gas field and provide exploration basis for the future development of oil and gas.


Duplicity is still the only hypothesis-free method to derive stellar masses. Whereas other techniques such as asteroseismology rely upon some stellar model, orbits of binary stars yield quantities directly related to either the sum of the masses or the individual masses of the two components. However, in order to derive those individual masses, it is necessary to combine at least two types of observations, e.g., visual and spectroscopic or photometric and spectroscopic. Gaia will make the three of them available but their combination will be an efficient source of masses for sub-groups of binaries only. For instance, given the precision of the radial velocities, how many orbital visual binaries (for which the mass sum is therefore accessible) will lead to a spectroscopic orbit required to derive the mass ratio and thus the individual masses?


The concept of distributive justice in Pre-Qin Confucian school represented by Confucius, Mencius and Xunciuswas founded on the theory of justice of human kindness and ritual. And its distributive principle is mainly by the inequality ofritual and morality as justice.


SeaSpace Corporation's TeraScan software has been employed in generating ocean and atmospheric data products from Terra and Aqua MODIS (Moderate Resolution Imaging Spectroradiometer) direct broadcast data. TeraPGS (TeraScan Product Generation System) is a system for automatically generating and distributing products according to user specifications. TeraPGS can generate and deliver both TDF (TeraScan Data Format) and picture products. In this paper we show examples of ocean color, cloud, and aerosol products derived from Terra and Aqua MODIS sensor data using TeraPGS. Ocean color products were generated using the MOD/spl I.bar/PR18 algorithms. Ocean chlorophyll was generated using the MODIS biooptical algorithm (MODCL2A). Aerosols and aerosol optical thickness (Tau/spl I.bar/865) was computed fromMODPR/spl I.bar/04/spl I.bar/05 andMODOCL2. Cloud products were generated using NASA's cloud mask (MODS 5) and cloudtop (MOD06CT) algorithms. These algorithms are identical to the NASA GSFC DAAC operational level-2 algorithms and have been fully integrated with TeraScan's TeraPGS software. The data processing flow examples will include level 0, level 1a, level 1b, earth-location, Image navigation, atmospheric correction and level 2 product generation from MODIS.


The fundamental risk factors for metabolic syndrome and risk for Cardiovascular Diseases (CVD) are hypertension, diabetes, smoking, high blood lipid levels, low physical activity, unhealthy eating patterns, overweight or obesity, a family history for predisposition of CVD and the new dimension of stress allostatic stress load. The cumulative effect of allostatic stress load at work is one of the risk factors in the genesis of CVD and metabolic syndrome. Stress affects both cardiovascular function, and metabolic lipid status. Markers of high allostatic load as indices of autonomic cardiovascular control and metabolic risk are involved in the process of adaptation under chronic stress exposure. In the process of adaptation to allostatic stress load, significant physiological and pathophysiological responses and mechanisms are induced and accelerated.


In order to use for development of future rehabilitation medicine, I express a general introduction and the contents about the technique how the community rehabilitation should be, which my experience produced. First, I describe my previous experience Related to the everyday life towards independence of the elderly with handicap, I pose a question concerning the state of the current rehabilitation as I see. Then, I show how life becomes easier by using a kind of rehabilitation when one is handicapped, called "the action of crawling", i.e., the baby-like behavior in order to improve a quality of life. And I describe what kind of rehabilitation is required in order to gain the activity. Furthermore, the situation of the people and practical cues for this kind of exercise and rehabilitation are shown.


Trying to establish a connection between the shapes of the skull and a predisposition to certain diseases of the ear, nose and its accessory cavities and various courses of the disease, V.E. Perekalin (Journal of the ear. Nose and throat, vol. III, No. 1 and 2) made a number of studies in this direction, and was convinced that the dolichocephalic skull, being the most perfect in design, is the least susceptible to these diseases. (9 words on 215).


The advent of Instructional Television for teaching and learning various programmed in the world is a field of immediate and increasing challenge to teachers. The term" Instructional television" refers to the use of Television medium in any of the various technical forms to present information ideas and experiences in any subject area and at any level of some portion of an organized educational programmed. Instructional Television as a multimedia approach can be applied in teaching various subjects in schools in order to stimulate student learning ability, interest and attitude in any given subject. A number of educational scholars have conducted researches on the use of Instructional Television for teaching and learning in many parts of the world and their findings reveal a significant increase in students' performances, attitude and interest with the use of Instructional Television. It is therefore imperative for teachers in Nigeria due to the ever increasing population of students in schools to start using this emerging instructional medium so as to achieve optimum student performances in various school subjects. This paper examined the usefulness of instructional Television in teaching and learning and its contribution to student's academic performance in schools. Finally, some useful recommendations were offered for consideration by Nigerian government.


Dear Editor, An 82-year-old Japanese man with a 40-year history of psoriasis was referred to us, because small tense bullae first appeared on the bilateral legs, and then spread over the whole body. Physical examination revealed small tense bullae on the normal skin and the scaly erythematous psoriatic lesions (Fig. 1a,b). Mucous membranes were not involved. Laboratory examinations showed increased leukocytes (10,000/lL; normal, 3900–9300/lL) with normal eosinophils (0.6%; normal, 0.2–4.1%) and normal C-reacted protein (0.042 mg/dL; normal, <0.3 mg/dL). An index in enzyme-linked immunosorbent assay (ELISA) was faintly positive for the recombinant protein (RP) of the BP180-NC16a domain (16.1; normal, <9), whereas indexes were negative for the RP of BP230, desmoglein 3, desmoglein 1 and type VII collagen. A biopsy taken from a bulla on the normal skin showed blister formation, infiltration of eosinophils and neutrophils in the blister, and mononuclear cells in the upper dermis (Fig. 1c), while another biopsy from a psoriatic lesion revealed hyperkeratosis, parakeratosis, acanthosis and Munro's microabscess in the horny layer (Fig 1d). Direct immunofluorescence (IF) showed linear depositions of immunoglobulin (Ig)G and C3 in the basement membrane zone (BMZ). Indirect IF using normal human skin revealed circulating IgG anti-BMZ autoantibodies at 1:160 dilution (Fig. 1e), which reacted with the epidermal side of 1 mol/L NaCl-split normal human skin at 1:10 dilution (Fig. 1f). In immunoblotting of concentrated culture supernatant of HaCaT cells, IgG antibodies in the patient serum reacted with linear IgA dermatosis antigen-1 (LAD-1) (Fig. 1g). There was no reactivity with the recombinant proteins of NC16a and C-terminal domains of BP180, normal human dermal extract or purified human laminin-332. Intravenous prednisolone 30 mg/day and subsequent 70 mg/day did not suppress progress of blister formation, whereas topical calcipotriol and betamethasone butyrate propionate were moderately effective for psoriasis. Then, the patient was treated with i.v. Ig 400 mg/kg per day for 5 days consecutively from day 19. The treatment suppressed new blister formation. Subsequently, betamethasone 6 mg/day was administrated, and tapered. The ELISA indexes of the BP180NC16a domain RP were 19.5 at day 24 and 3.6 at day 52.


Objective To investigate the nursing care of neonates during recovery from general anes-thesia in NICU. Methods The accurate nursing care methods for 38 neonates during recovery from general anesthesia in NICU of our hospital were summarized. Results With professional and accurate care, none of them had an accident or the effect of the operation was influenced. Conclusion To be rigorous in work and own professional skill of the nurses in NICU was very important, which could guarantee the neonates to live through recovery from general anesthesia and to ensure the operation successful.

Key words:
Neonate;  General anesthesia;  Recovery;  Care


The Office of Graduate Studies has verified and approved the above named committee members. iii I would like to sincerely thank my two advisors, Dr. Bob Zmud and Dr. Joey George, whose wisdom, guidance, and extreme patience made this dissertation possible. I truly appreciate their insights, suggestions, and granting me the opportunity to complete this effort. I would also like to thank my other committee members, Dr. William Anthony and Dr. David Paradice, for their help and support in making this effort possible. I thank you all and wish you all the best. Finally, I would like to thank my family for all the help and support they have given me over these many years. I know it was very hard for all of us but I could not have finished without their support and sacrifice. I simply could not have done it without them and hope that someday I can make it up to them. Thanks. iv TABLE OF CONTENTS List of Tables vi List of Figures viii Abstract ix 1.


The paper presents an econometric approach to calculate the three-tier system of integral indices of innovation mesoeconomics development based on knowledge indicators. This approach serves to measure cognitive endogenous economic growth factors. On the basis of the role of innovations as a fundamental source of endogenous cognitive economic growth, the need for improving mesoeconomic measurements by separating the sphere of production and dissemination of knowledge is emphasized. According to the principles of endogenous growth theory, the author proposes a system of knowledge indicators predictors of economic growth in the region. It involves the use of an interdisciplinary approach to study the classification of economic growth factors, the theoretical propositions of knowledge management, the information base and methods of multivariable data analysis: receiving the combination groups and panel data. The need to apply multivariate statistical methods in the analysis of stochastic information is emphasized. The method of measuring and modeling the spatial heterogeneity of the innovation economy based on panel data is proposed. The article mainly presents conceptual judgments and general recommendations. Therefore, more detailed calculations and experimental developments can be made within future research. The proposed approach to measure the cognitive growth factors may be useful to improve monitoring in the system of state strategic planning with the aim of improving the efficiency of innovation and gaining competitive advantages of the region's economy.


An intelligent software system consists of intelligent components, fundamentally modeled by neural networks, and traditional software components, in which the intelligent components are responsible to make decisions. Thus, intelligent systems can adapt to environment changes in the running time. However, due to the fact that a neural network highly relies on the training data, its structure and quality are both uncertain. These uncertainties will be passed to the rest of the software system by the intelligent components. This paper presents a framework to model checking such kind of intelligent system software.


We review Gröbner–Shirshov bases for Lie algebras and survey some new results on Gröbner–Shirshov bases for [Formula: see text]-Lie algebras, Gelfand–Dorfman–Novikov algebras, Leibniz algebras, etc. Some applications are given, in particular, some characterizations of extensions of groups, associative algebras and Lie algebras are given.


Massive energy consumption and carbon emission has become one of the problems that limit the sound development of shipping industry. Ships without exhaust heat recovery, have massive heat discharged directly and wasted. Thermoelectric power generation (TEG) is an effective and environment-friendly technology to recover ships' exhaust heat. Based on previous research, this study mainly focuses on the recovery of exhaust heat produced by the incinerator on board, which is less researched before. Firstly, the operating parameters of typical incinerators on board are obtained and the available exhaust heat is calculated. Secondly, based on TEG, a scheme is made for incinerators on board to recover exhaust heat, and related experimental device is also set up. The heat recovery performance of the device is studied in several typical operating conditions of the incinerator. When the exhaust temperature reaches 450? and 520?, the TEG can produce a power of 776W and 882W respectively. The thermal efficiencies also exceed 4%, with an efficiency of 4.2% and 4.36% respectively. Thirdly, based on the experimental data, a TEG prototype for the incinerator on the YuKun ship is designed and its performance is evaluated. According to the estimation based on the experimental data, the TEG prototype, which has a length of 1 meter and is proposed in this dissertation, can theoretically produce a power of 9.45 kW.


Purpose: It has been reported that activating KRAS mutations negatively affect response to anti ^ epidermal growth factor receptor (EGFR) monoclonal antibodies in metastatic colorectal cancer.The mutation status of signalingmolecules downstream of the EGFR target is thus crucial to predict clinical benefit to EGFR-targeted therapies. Other mechanisms of resistance to EGFR inhibitors could involve activating mutations of the other main EGFR effector pathway, i.e., the PI3K/PTEN/AKT pathway. Experimental Design:We analyzed the PIK3CA and KRAS mutation status in a large group (n = 200) of chemorefractory metastatic colorectal cancers treated with cetuximab (Erbitux) in monotherapy or in combinationwith irinotecan, and correlated themutation status with outcome. Results:Twenty-three (12%) of the 200 samples carried1of the PIK3CA mutations included in our assay.We found no correlation between the presence of a PIK3CA mutation and impaired response to cetuximab. Conclusions:Our findings do not provide any evidence for a strong role ofPIK3CA mutations as a single marker in determining response to cetuximab in chemorefractory metastatic colorectal cancer. The identification of patients with colorectal cancer that respond to the epidermal growth factor receptor (EGFR) inhibitors cetuximab and panitumumab remains a major challenge. It is well-established that activation of the EGFR pathway triggers a complex program of intracellular signals. The two major pathways activated by the EGFR are the KRAS/RAF/MEK/ ERK 1/2 pathway, which controls gene transcription, cell-cycle progression, and cell proliferation, and the PI3K/PTEN/AKT pathway, which activates a cascade of antiapoptotic and prosurvival signals. It has been shown recently that KRAS, a small G-protein downstream of EGFR, can acquire activating mutations, which isolate the KRAS/RAF/MEK/ERK1/2 pathway from its receptor and thereby render EGFR inhibitors ineffective. As a result, activating KRAS mutations negatively affect response to anti-EGFR monoclonal antibodies in metastatic colorectal cancer (1–3). The mutation status of signaling molecules downstream of the EGFR target is thus crucial to predict clinical benefit to EGFR-targeted therapies. Although patients without a KRAS mutation exhibit a much better response to EGFR inhibitors, not all of them respond to treatment. For instance, the response rate to cetuximab in advanced colorectal cancer patients with wild-type (WT) KRAS tumors was still limited to only 40% (3). Other mechanisms of resistance to EGFR inhibitors thus exist, and could for instance involve activating mutations of the other main EGFR effector pathway, i.e., the PI3K/PTEN/AKT pathway. Indeed, a recent report by Perrone et al. (4) investigated a cohort of 54 colorectal cancer tumors treated with cetuximab, and identified 4 mutations in the PIK3CA gene, which is the p110a catalytic subunit of PI3K, in patients not responding to cetuximab, thereby suggesting that mutations in PIK3CA cause resistance to cetuximab. In the current study, we further investigated the PIK3CA and KRAS mutation status in a much larger group (n = 200) of chemorefractory metastatic colorectal cancers treated with cetuximab (Erbitux) in monotherapy or in combination with irinotecan, and correlated the mutation status with outcome. Our aim was to investigate a possible role of PIK3CA mutations in resistance to cetuximab in KRAS WT patients.


Based on characteristic of road landslide,the prevention technology of road landslide is studied in the aspects of like drainage,retaining wall,reducing the pressure,reinforcement and tree planting.It can provide reference for road landslide research and practice.


This thesis aims at the saving energy problem for the axial flow fan with speed regulation,it begins with all air pressure equation of the axial flow fan,and derives the condition of the minimum energy consumption from the optimum control principle.


Encouraging people to make healthier food choices will make an important contribution to preventing non-communicable diseases. Most groceries purchased by UK households are from supermarkets, potentially making this an important setting where consumers might consider the nutritional quality of foods. While it is possible to purchase healthy food in supermarkets, the retail environment actively promotes the selection of less healthy items. Gaps remain in our understanding about which store based interventions - including providing on-pack nutrition information - can assist shoppers to make healthy food selections. Considerable evidence exists around consumer engagement with nutrition labelling, but there is a paucity of research conducted in real-life contexts. This thesis describes a qualitative study which explored factors which influence decision making at point-of-choice and sought to understand whether and how shoppers use the front of pack nutrition information panel during routine supermarket shopping. The study also investigated whether wearable cameras were useful research tools to understand how shoppers use the front of pack nutrition information panel, compared to a 'Think aloud' method. In this research, participants paid little attention to the front of pack nutrition information as they shopped. Food shopping was characterised as a complex, involved activity with priority given to a range of different issues over health and/or nutrition concerns. Although the front of pack nutrition information panel could offer support to shoppers, this study suggests that its presence is currently overwhelmed by commercially driven factors. Shoppers appear to need specific health or nutrition-related purchasing goals, be sufficiently informed and motivated to spend time attending to the front of pack nutrition information panel. Future interventions should raise awareness of the presence of nutrition information on pack and be clear about how this information can be used in different circumstances to guide consumers towards healthier choices. The study suggests that while data collected via 'Think aloud' or from viewing wearable camera images provides general information about food shopping decisions, eye-tracker technology can provide objective evidence of nutrition information use. Data capture was greatly strengthened by the use of a post-shop interview, where interviews generated specific and important contextual information relating to the use of the front of pack nutrition information panel.


The development of systems with permanent magnets requires improving their calculation methods. At present, it is impossible to create complex devices with high energy parameters without accurate methods of calculation of the magnetic field and optimization calculations. The calculation of the magnetic field demands the complex digital model with using the finite element method. The optimization methods demand a lot of calculation cycles when optimal parameters are selected. So, on the one hand, the mathematical model has to have a very simple method of calculating the magnet field parameters, but on the other hand, this model must be very accurate. We have a conflict in this case. Simple models have a bad precision but they calculate the magnet parameters very quickly and it is possible to use these methods for optimization circles. Complex methods using the Ansys, Cosmos etc. software have an excellent accuracy, but they demand great computer resources and a lot of time for their operation. It is impossible to use them for optimization circles. In this article, the method, which can solve this problem, is suggested. The method is based on the finite element method to create the digital model of magnet system, but for the realization of this method not a large number of elements is used. So, this method is simple and has a good accuracy. It is possible to use this method for optimization models to design systems with permanent magnets.


Background: Oral health-related quality of life (OHRQoL) is used for evaluating needs of people, their health problems, their level of satisfaction, and various effects of any intervention which have been provided for recording of various nonclinical aspects of oral health. Aim: The objective of the study was to compare OHRQoL and its association with periodontal health among adult population. Materials and Methods: This prospective and cross-sectional study was conducted on 300 respondents who were diagnosed with periodontitis. 14-item containing Oral Health Impact Profile 14 (OHIP-14) questionnaire was used for study analysis. A single observer made clinical examinations. Mann–Whitney "U" and Kruskal–Wallis statistical tests were used for comparing the OHIP-14 scores. Statistically significance was set at P < 0.05. Results: Majority of study participants were of female gender (62.0%). A significant association was observed between loss of attachment and OHIP14 scores (P = 0.003). Conclusion: Poor periodontal health may affect the OHRQoL.


When investigating the concept of sexuality, due consideration should be given to novel humanistic approaches that deeply concern philosophical and ethical aspects of the individual as well to the usual medical, psycho-social, and legal issues. Modern-day sexology seeks for an exchange of experiences, study outcomes, and subject matter, which aims to serve towards an understanding of human sexuality from puberty onwards; indeed, such a perspective can be used in children suffering from sexual abuse/violence. Key woRds: sexology, sexual ethics, children's sexual abuse. addRess foR CoRRespondenCe: Magdalena Pisarska-Krawczyk, Higher Vocational State School in Kalisz, 4 Nowy Świat Street, 62-800 Kalisz, Poland, e-mail: email@example.com DOI: https://doi.org/10.5114/jhi.2017.74216 The ways in which harm/evil arises whenever sexual abuse of children occurs is complex, as is its actual reality. It should be remembered that when such abhorrent issues are considered, both victim and perpetrator need to be taken into account, respectively: "dramatis personae" and "perperatos". The context of this problem is also profoundly historical. Throughout history, sexual freedom has been frequently misunderstood, leading to tragedy. Cardinal Stefan Wyszynski delivered his telling pronouncement on this matter: "The sanctity of the human person must be protected and not devalued". Sexuality is one of the fundamental endowments of the human condition, and this bounty becomes depraved and ruined upon its abuse. The scale and the burden of harm to innocent children are enormous, and become manifest in all the subsequent stages of the child's development. A child is a person with their own dignity, which (....) should be respected; sexual child abuse strikes down the very dignity of the child as well as its innocence in all the ways as understood within the context of Freudian psychoanalysis. Child sex abuse is an evil, and as the worst possible harm that can befall a child, it can never be held as being a "forbidden normality" [1-7]. Human sexuality cannot be considered without taking into account somatic and biopsychosocial conditions, along with sexual ethics and the great works of John Paul II, Joseph Tischner, or other renowned ethicists. The issue of ethics within the practice of sexology or sexual therapy is a very complex subject. The diverse types of deontic norms defined in various laws/codices are one thing, but each individual case that a sexologist has to deal with is another. Their specific class, which potentiates the tension existing between generality of norms with given circumstances, belongs to the realm of moral conflicts. Upon stressing the importance of the sexologist being reflective, in terms of general and specific ethics, the inalienable role of moral awareness and the physician's conscience should nevertheless be remembered, which allows optimal choices to be made concerning therapy, treatment, and the wellbeing of the person-patient, without the physician imposing their own axiomoral and normative standards. From the ethics of ancient history, making such choices was termed phronesis (i.e. practical wisdom). Indeed, sexologists should be phronetic. It should be noted that lying behind concrete decision-making are perceptions of humanity


Dysregulated hormonal, metabolic and neural signalling within and between organs can contribute to development of metabolic diseases including type 2 diabetes. Insulin-antagonistic effects of hormones, cytokines and excess metabolic substrates such as glucose and fatty acids may be exerted via common mechanisms involving for example reactive oxygen species (ROS) accumulation and associated inflammatory responses. Visceral adiposity is a central component of the metabolic syndrome and it is also eywords:


Objectives: The authors of the RTOG 91-11 study recently presented long-term outcomes for 3 nonsurgical treatment strategies to preserve the larynx in patients with locally advanced laryngeal cancer. They concluded that concomitant chemotherapy and radiation is optimal for laryngeal preservation; however, 16% of the patients still required total laryngectomies (TL). Additionally, the incidence of pharyngocutaneous fistulas was 30% within this cohort receiving total laryngectomy. We therefore conducted a single center retrospective study of 47 patients treated with total laryngectomy at a tertiary care center from July 2004 to May 2013 to assess the percentage of patients that develop pharyngocutaneous fistula. We propose that the rate of pharyngocutaneous fistula in patients that receive TL will be lower using the technique of flap augmentation compared with the patients that receive TL using the technique of primary closure. Methods: Thirty-two patients received primary closure for TL with a pharyngocutaneous rate of 9.4% (n = 3), and 14 patients received flap augmentation for TL with a pharyngocutaneous rate of 7.1% (n = 1). We also assessed stage of laryngeal cancer; whether the patient received cheomotherapy, radiation therapy, or concomitant radiation and chemotherapy; the muscle used for flap closure; recipient artery and vein; thyroid-stimulating hormone, hemoglobin, intact parathyroid hormone, and albumin preoperative and postoperative values, when available. Results/Conclusions: The rate of pharyngocutaneous fistula was comparable between the primary closure group and the flap closure group (P = 1). However, because of the low rate of pharyngocutaneous fistulas, it would be necessary to analyze a larger cohort to determine significance and possible confounding factors.


Dev et al., "Regulation of Synthesis of Serine Hydroxymethyltransferase in Chemostat Cultures of Escherichia coli 259(13) The Journal of Biological Chemistry 8394-84.01 (1984).* Mulligan et al., "An assay for betaine-homocysteine methyltransferase activity based on the microbiological detection of methionine"9 Journal of Nutritional Biochemistry 351-354 (1998).* Tani et al., "Chip-Based Bioassay Using Bacterial Sensor Strains Immobilized in Three-Dimensional Microfluidic Network'76 Ana lytical Biochemistry 6693-6697 (2004).* Simon et al., "Direct Homocysteine Biosynthesis from O-Suc cinylhomoserine in Escherichia coli: an Alternate Pathway That Bypasses Cystathionine" 153(1) Journal of Bacteriology 558-561 (1983).* Dev et al., "Role of Methionine in the Regulation of the Synthesis of Serine Hydroxymethyltransferase in Excherichia coli' 259(13) The Journal of Biological Chemistry 8402-8406 (1984).* Bialecka et al. (May-Jun. 2009) "Genetic and Environmental Factors for Hyperhomocysteinaemia and Its Clinical Implications in Parkinson's Disease." Neurologia i Neurochirurgia Polska 43(3):272-285. Blommeletal. (2007) "Enhanced Bacterial Protein Expression Dur ing Auto-Induction Obtained by Alteration of Lac Repressor Dosage and Medium Composition." Biotechnol Prog 23:585-598. Datsenko et al. (2000) "One-Step Inactivation of Chromosomal Genes in Escherichia coli K-12 Using PCR Products." PNAS 97(12):6640-6645. Dietzen et al. (2008)"Rapid Comprehensive Amino Acid Analysis by Liquid Chromatography/Tandem Mass Spectrometry: Comparison to Cation Exchange with Post-Column Ninhydrin Detection." Rapid Commun Mass Spectrom 22:3481-3488. Le Boucher et al. (1997) 'Amino Acid Determination in Biological Fluids by Automated Ion-Exchange Chromatography: Performance of Hitachi L-8500A." Clinical Chemistry 43(8): 1421-1428. Lyietal. (2007) "Biochemical and Molecular Characterization of the Homocysteine S-Methyltransferase from Broccoli (Brassica oleracea var: italica)." Phytochemistry 68: 1112-1119. Molloy et al. (Apr. 2009) "The Search for Genetic Polymorphisms in the Homocysteine/Folate Pathway That Contribute to the Etiology of Human Neural Tube Defects." Birth Defects Research (Part A) 85:285-294. Nilsson et al. (2008) "Plasma Homocysteine and Vascular Disease in Elderly Patients with Mental Illness." Clin Chem Lab Med 46(11): 1556-1561. Papatheodorou et al. (2007) "Vascular Oxidant Stress and Inflamma tion in Hyperhomocysteinemia, Antioxidants & Redox Signaling 9(11): 1941-1958. Refsum et al. (2004) "Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion." Clinical Chem istry 50(1):3-32, published electronically May 13, 2008. Reznikoffetal. (2004)"Tn5 as a Molecular Genetics Tool." Methods in Molecular Biology 260:83-96. Seshadri et al. (2002) "Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease." N EnglJ Med 346(7):476-483. Van Dam et al. (2009) "Hyperhomocysteinemia and Alzheimer's Disease: A Systematic Review." Archives of Gerontology and Geri atrics 48:425-430. Van Meurs et al. (2004) "Homocysteine Levels and the Risk of Osteoporotic Fracture." N Engl J Med 350(20):2033-2041. Weiss N. (2005) "Mechanisms of Increased Vascular Oxidant Stress in Hyperhomocysteinemia and Its Impact on Endothelial Function." Current Drug Metabolism 6:27-36. Wheeler S. (2008) "Assessment and Interpretation of Micronutrient Status During Pregnancy." Symposium on Translation of research in nutrition II: the bed. Proceedings of the Nutrition Society 67:437 450. Yoshida et al. (2003) "Homocysteine Biosynthesis Pathways of Streptococcus anginosus." FEMS Microbiology Letters 221:277-284.


Only scientific and reasonable nutritional support treatment, can reduce complications to the maximum extent, so that patients will rehabilitate faster and more stably. Authors integrate bundles of care from enhanced recovery after surgery, combined with the latest research progress domestic and overseas, to discuss nutritional status and nutritional risk screening, focus of perioperative nutrition support therapy, key issues on the pre-, intra- and post-operative periods of nutritional support treatment, and strategy of throughout nutritional management during perioperative period. These includes the following aspects: integrating nutrition management into perioperative period management; avoiding fasting before surgery; resuming oral feeding early; early nutritional support therapy for high nutritional risk patients; metabolic control, such as positive control of blood glucose; reducing stress related catabolism or factors affecting gastrointestinal function recovery; decreasing postoperative anesthesia drug use for ventilator management; early activity to promote protein synthesis and muscle function recovery.

Key words:
Surgical procedures, operative; Enhanced recovery after surgery; Perioperative period; Nutritional support therapy


A highly-sensitive temperature sensor with controllable sensitivity based on Vernier effect by cascading a tunable extrinsic Fabry-Perot interferometer (FPI) and a fixed reflective Lyot filter (RLF) is theoretically investigated and experimentally demonstrated. The temperature sensitivity can be tuned by modulating the cavity length of the extrinsic FPI and online monitoring the envelope of superimposed spectrum with optical spectrum analyzer (OSA). The FPI works as the reference arm to tune the temperature sensitivity of the sensing system, while the RLF with 1-meter polarization maintaining fiber (PMF) acts as the sensing probe. Experimental results prove that by changing the cavity length of the FPI, the sensitivities of −3.82 nm/°C, −8.33 nm/°C and −14.63 nm/°C can be achieved. Compared with the single sensing element, the sensitivities are magnified by 3.78, 8.25 and 14.49 times. The proposed temperature sensor is feasible to be applied practically in scenarios which require different temperature sensitivities in demanded temperature detection ranges.


ABSTRACT There is a perceived need to clearly identify the major types of entrepreneurship education and training and their target populations. A wide range of activities have been undertaken recently to develop enterprise in youth in Belgium. However, up to this moment, there seems to be a lack of total coherence.


This paper focuses on the composition analysis and type identification of ancient glass objects. The correlation between the weathering of the surface of glass artifacts and its type, color and decoration is obtained by establishing a chi-square test model based on the characteristics of fixed class variables. After that, the prediction model was established based on the weighted average method according to the characteristics of the data, and the predicted value of each chemical composition before weathering was solved.


The rainbow trout (Salmo gairdneri) growth hormone (GH) cDNA clone isolated previously programs the synthesis in Escherichia coli of a chimeric GH polypeptide that differs from the mature form of the natural hormone by an additional 11 amino acid residues at the NH2-terminus. Treatment of yearling rainbow trout with an enriched preparation of this recombinant GH resulted in enhancement of growth. Specific growth rates, weight increase, and length increase of GH-treated fish were markedly higher than those of the mock-treated or untreated fish. In addition, the chemical composition and ultrastructure of muscle tissue of GH-treated fish were not significantly different from that of control fish. These results suggest that the recombinant GH possesses growth-promoting activity and that GH-treatment results in not only accelerated but also normal growth of fish.


In several applications, MRI is used to monitor the time behavior of the signal in an organ of interest; e.g., signal evolution because of physiological motion, activation, or contrast‐agent accumulation. Dynamic applications involve acquiring data in a k–t space, which contains both temporal and spatial information. It is shown here that in some dynamic applications, the t axis of k–t space is not densely filled with information. A method is introduced that can transfer information from the k axes to the t axis, allowing a denser, smaller k–t space to be acquired, and leading to significant reductions in the acquisition time of the temporal frames.


In the present study, we consider a f -Kenmotsu space form M (c) and we investigate its lightlike hypersurfaces. We prove the non-existence of these type hypersurfaces of an f -Kenmotsu space form when f is a constant function and it takes different values from −c or 3c and so we give a chracterization of lightlike hypersurfaces on a f -Kenmotsu space form. Finally, we obtain some related properties.


An ALD thin film deposition equipment and cleaning method wherein the reactor comprises: a reactor block (110) on which a wafer can be mounted; a shower head plate (120) for maintaining a predetermined pressure constant by covering the reactor block; a diffusion plate (130) installed on a lower surface of the shower head plate (120), the diffusion plate (130) having a plurality of spray holes (131) formed over the wafer (w) to spray the first reaction gas and/or inert gas and/or cleaning gas transferred via the first reaction gas supply line onto the upper surface of the wafer block (140), and a plurality of nozzles (133) slanted toward the inner sidewall of the reactor block to spray the second reaction gas and/or inert gas and/or cleaning gas transferred via the second reaction gas supply line; and a wafer block (140) installed within the reactor block (110), on which the wafer can be seated, and, preferably, wherein the ALD thin film deposition equipment further comprises a coolant passage in the shower head plate in order to decrease the temperature of the diffusion plate (120) to a desired temperature range.


Daily decisions are made which determine the physical nature of our cities, and in most cases they are based on short-term economic and func tional considerations. However, we can in our time design cities which are functional, ordered and aesthetically enjoyable. The sketches attempt to sug gest how to achieve urban forms appropriate for urbanity.


This article begins by discussing the context and major policies as well as the rationales related to internationalization of the university curricula in Japan. It then touches on internationalization of the curricula in Japanese higher education institutions at home and on development of cross-border curricula that are both imported into Japan and provided in higher education institutions abroad. The article concludes by arguing that internationalization of the university curricula in Japan has changed to the extent that it no longer plays the minor and unimportant role in attracting and hosting international students that used to be expected in the early 1980s. Currently internationalization of the university curricula in Japan is not confined merely to the development of language education for both international students and Japanese students at home but also involves a variety of cross-border educational initiatives.


Transteoretic Model (TTM) is widely used to improve health behavior change process and to achieve the most effective health behavior change. TTM is used as a guide to facilitate behavior change. The Transteoretic Model is a cognitive behavioral model that accepts that an individual does not have any behavioral change at a time and that the behavioral change involves different stages and processes. The purpose of this review is to define the stages of behavior change by using Transteoretic Model and to provide resources to researchers, nurses and other health professionals who will use the model in order to realize basic information and behavior changes.


Practice Teaching is an important way to train the students in practical ability and the innovation spirit, which is an important part in higher education teaching system.Because of the practical characteristics of logistics disciplines, the practice teaching of logistics becomes more important.Based on analyzing the existent problems in higher education practice teaching system, we improve and build the logistics practice teaching system from the logistics system conditions, models and affecting factors.Especially, we discuss the logistics practical teaching models in higher education.


[structure: see text]. 5-Endo-dig cycloisomerization of 1,4-di- and 1,2,4-trisubstituted but-3-yn-1-ones in the presence of a catalytic amount of zinc chloride (10 mol %) in dichloromethane at room temperature (22 degrees C) provides 2,5-di- and 2,3,5-trisubstituted furans in high yields (85-97%).


In this paper we compare hardware efficiency and compression performance of various filter-bank structures available for the realization of Daubechies 9/7 biorthogonal filter bank used in wavelet image coding and specified in JPEG 2000 image coding standard. The comparison includes convolution-based structures, as the direct-form, cascade, and polyphase structures, and the lifting-based structure. While the lifting-based structure requires half the number of operations for realizing a biorthogonal filter bank, direct-form and polyphase structures have a better finite-word-length performance. Moreover; operations in a polyphase filter bank require processing at half the rate required by lifting-based structures


Sciatica, or more properly sciatic pain, has always been of importance clinically not only because of its prevalence and its resistance to treatment but because it may be a symptom of so many disease entities. The treatment of sciatic pain of uncertain origin has been complicated by the search for a single therapeutic procedure of sufficient potency to produce immediate and complete relief in all cases. Apparently such a procedure has been difficult to find, for of the various types of treatment reported in the literature not one has had universal success. After analyzing the different methods of treatment for sciatica at the Mayo Clinic, it is evident that the different procedures can be combined into two methods, the ambulant and the institutional, with satisfactory results in a fairly high percentage of cases. Cooperation of orthopedists, neurologists and neurosurgeons has made it possible to correlate the results, and we are


We improve upon Huntington's affine geometry by showing that his independence proofs can be, in some cases, simplified. We carry out a systematic investigation of the strict notion of betweenness that Huntington employs (the three arguments are supposed to be distinct) by comparing it to McPhee's three axiom systems for the same intended class of structures, which employs weak betweenness (the arguments are permitted to be equal). Upon closely inspecting the proof that McPhee's axiom systems are equivalent to Huntington's (subject of course to the definition of weak betweenness in terms of strict and vice versa), one finds surprisingly that McPhee's axiom systems have quite different relations to strict betweenness.


Twenty small new impact craters or clusters have been observed to excavate bright material inferred to be ice at mid‐latitudes and high latitudes on Mars. In the northern hemisphere, the craters are widely distributed geographically and occur at latitudes as low as 39°N. Stability modeling suggests that this ice distribution requires a long‐term average atmospheric water vapor content around 25 precipitable micrometers, more than double the present value, which is consistent with the expected effect of recent orbital variations. Alternatively, near‐surface humidity could be higher than expected for current column abundances if water vapor is not well mixed with atmospheric CO2, or the vapor pressure at the ice table could be lower due to salts. Ice in and around the craters remains visibly bright for months to years, indicating that it is clean ice rather than ice‐cemented regolith. Although some clean ice may be produced by the impact process, it is likely that the original ground ice was excess ice (exceeding dry soil pore space) in many cases. Observations of the craters suggest small‐scale heterogeneities in this excess ice. The origin of such ice is uncertain. Ice lens formation by migration of thin films of liquid is most consistent with local heterogeneity in ice content and common surface boulders, but in some cases, nearby thermokarst landforms suggest large amounts of excess ice that may be best explained by a degraded ice sheet.


Weekly counts of Boophilus microplus (Canestrini) on 30 Australian Illawarra Shorthorn heifers enabled the cattle to be ranked in order of tick infestation, with highly significant correlations between counts of two observers and between counts of one observer on different occasions. In May 1960, when the heifers were 1½–2 years old, 12 were selected as relatively tick-resistant and 12 as relatively tick-susceptible. Each of these groups was divided at random into herds of six, and the four herds were then allotted randomly to separate paddocks, each onequarter of the area previously grazed. A herd was sprayed with 0.5% DDT emulsion when its average count of ticks (adult females over 5 mm in length) on one side of the animals exceeded 40. During the ensuing tick season, from October 5, 1960, to June 7, 1961, the sums of average weekly tick counts, and the numbers of sprayings (in parenthesis) were: susceptible herds 4853 (5) and 5962 (6): resistant herds 718 (0) and 1073 (1). Counts of tick larvae on defined body areas showed that, in the summer after segregation, resistant herds carried fewer larvae than the susceptible herds, apparently because fewer mature ticks fell from the resistant cattle in the preceding spring and winter. As a consequence of this, counts of adult ticks were comparatively lower after than before segregation. There was little or no 'spring rise' of tick infestation on the resistant herds. There was no significant correlation between tick resistance and coat score, sweat gland dimensions, or total skin thickness, but a correlation of -0.53 with follicle depth was significant at the 1% level. There was no evidence of adaptation of cattle ticks to the resistant animals, either in the field experiment or in observations on stalled cattle. The experiment draws attention to the appreciable proportion of tick-resistant animals within the Australian Illawarra Shorthorn breed, which has largely been overlooked in past discussions on tick-resistant breeds of cattle. It also suggests a technique for estimating the improvement in tick control that may be obtained by a given degree of selection within any breed, for any given environment.


ABSTRACT: Based on many years of stewardship experience in natural areas in Illinois and Pennsylvania, I discuss the potential for roadside mowing to facilitate the spread of aggressive alien plants. Along interstate highways, mowers are a potential mechanism for spread of aggressive plants for long distances. Other factors that may be important are favorable climatic and soil conditions, and positive responses by aliens to disturbances caused by mowing along these highways. This report outlines some differences and similarities between central Illinois and south-central Pennsylvania, which have similar climatic conditions but different soils and length of settlement time.


This study analysed age‐related water‐use dynamics across three temperate conifer forest plantations (aged 11, 39 and 74 years, as of 2013, henceforth referred to as TP02, TP74 and TP39, respectively, where the last two digits represent the year of planting) in southern Ontario, Canada, from 2008 to 2013. Eddy covariance‐measured mean evapotranspiration over the growing season (April–October) was 438 ± 19, 392 ± 19 and 323 ± 25 mm at TP39, TP74 and TP02, respectively. Daytime bulk surface conductance was highest and most variable at the TP39 site (8.5 ± 4.0 mm s−1), followed by the TP74 (7.0 ± 2.8 mm s−1) and TP02 (5.4 ± 2.5 mm s−1) sites. Evapotranspiration at all the forests was sensitive to air temperature and tended to decrease with increasing atmospheric dryness. The youngest forest's evapotranspiration was most conservative, which led to an increase in water‐use efficiency throughout the study period, in particular during drought events. The oldest forest was the least restrictive in its water use during drought, which led to lower water‐use efficiency during such events as compared with the younger forests. The oldest forest was thinned in early 2012, when about one third of trees were commercially harvested. No significant change in evapotranspiration or water‐use efficiency was observed at this site following thinning; however, daytime bulk surface conductance declined. Our results suggested that changes in stand structure with forest ageing, such as reduction in stem density and increase in sapwood area, were responsible for differences in soil water demand during drought and non‐drought periods, leading to differences in forest water use. Hence, forest age, because of its structural implications, is an important control on stand‐level water‐use efficiency and forests' response to drought events. Our study suggested that younger forests may be best suited to maximize growth and carbon uptake efficiency under rising air temperatures and increasing precipitation variability as predicted by climate models for eastern North America. Copyright © 2015 John Wiley & Sons, Ltd.


In essence, the English teaching process in colleges and universities is a learning process of foreign language culture. Teachers in colleges and universities just use this learning process to penetrate humanistic education into English teaching and to integrate with it, so as to help students to improve their humanistic quality. Given this, this paper first gives a statement onto internal relations between English teaching in colleges and universities and humanistic & spiritual education. Based on the special historical background of China at present, this paper discusses new requirements of new times for humanistic & spiritual education in English teaching in Chinese colleges and universities. Moreover, an analysis is made onto relevant causes for deficiency of humanistic education in English teaching in Chinese colleges and universities. Based on current conditions and existing deficiencies of English teaching in Chinese colleges and universities, effective countermeasures and recommendations are proposed in this paper for the implementation of humanistic education in English teaching in Chinese colleges and universities, with certain positive reference to the promotion of teaching practices.


Soil is one of the most important natural resources for existence of living creatures. Yet, it is non-renewable and finite natural resource. Indiscriminate use of soil coupled with lack of proper management has led to its degradation echoing the concerns of the planners, researchers and farmers (Sharma, 2006). This calls for a scientific approach in studying, management and development of this natural resource at various levels. Soil International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 10 (2017) pp. 2699-2712 Journal homepage: http://www.ijcmas.com


Background: Sickle Cell Anemia (SCA) is an inherited disorder which is associated with significant morbidity and mortality. Early recognition as well as prompt and effective management of the morbidities seen in SCA is key to the survival of patients with the disease. Objective: To determine the morbidity profile and outcome of patients with sickle cell anemia (SCA) admitted into an Emergency Pediatric Unit (EPU) of a tertiary health center in Nigeria. Methods: A retrospective study in which records of admissions of children with SCA over a two-year period (June 2011 to May 2013) were obtained from the EPU records. Information retrieved included age, sex, diagnosis and outcome as far as the unit is concerned. Results: One hundred and forty-seven children, 11.9% of the total (1,234 patients) EPU admission, aged between six months and 18 years (mean age being 84.76 ± 57.24 months) were studied. Male: female ratio was 1.3: 1. Vaso-occlusive (53.2%), hyper-hemolytic (37.6%) and acute sequestration crises (9.2%) were noted but no case of aplastic crisis was seen. Among infections, Malaria (56.2%), Sepsis (15.6%) and pneumonia (12.5%) were the major cases documented. Two (50-0%) patients died of acute sequestration crisis, one (25.0%) of meningitis and another (25.0%) of hyper-hemolytic crisis with severe anemia. Mortality rate was 2.7%. Conclusion/ Recommendation: SCA admissions in our EPU are mainly due to vaso-occlusive crises and infections. Acute sequestration crisis was the leading cause of death followed by meningitis and hyper-hemolytic crisis. Prompt and effective transfusion services, the use of pneumococcal conjugate vaccine as well as judicious use of appropriate antibiotics will augment the chances of survival in these children.


A Bayesian network (BN) Charniak (1991) Pearl (1988) Jensen (1996) Neapolitan (1990) is a directed acyclic graph (DAG) consisting of nodes and arrows, in which node represents random variables, and arrow represents dependence relationship between connected nodes in the sense of the probabilistic, deterministic, or functional. Each node in BN has a specified conditional probability distribution (CPD), where all CPDs together parameterize the model. BNs have been used as powerful probabilistic knowledge models for decision support under uncertainty over a few decades, with numerous applications such as classification, medical diagnosis, bioinformatics, speech recognition, etc. One of the most important features BN has is the factorization of the joint probability space, so that conditional independence can be exploited to simplify modeling and save computations. However, BN model is only useful when combined with efficient algorithms for inference.


Polarization-induced doping in the gradient variation of Al composition in p-Al
 0.75
 Ga
 0.25
 N/Al
 x
 Ga
 1-x
 N hole injection layer (HIL) for deep ultraviolet light-emitting diodes (DUV-LEDs) with ultra-thin p-GaN (4 nm) ohmic contact layer capable of emitting 277 nm have been investigated. The experimental results show that the external quantum efficiency (EQE) and wall plug efficiency (WPE) of the structure graded from 0.75 to 0.55 in the HIL reach severally 5.49% and 5.04%, which are improved significantly by 182% and 209%, respectively, compared to the structure graded from 0.75 to 0.45, exhibiting a tremendous improvement. Despite both theoretical speculations and simulation results support that the larger the difference between 0.75 and x in the HIL, the higher the hole concentration should be induced; thus, the DUV-LED has a higher internal quantum efficiency (IQE). Meanwhile, as the value of x decreases, the absorption of the DUV light emitted from the active region by the HIL is enhanced, reducing the light extraction efficiency (LEE). The IQE and LEE together affect the EQE performance of DUV-LEDs. To trade off the contradiction between the enhanced IQE and decreased LEE caused by the decrease of Al composition, the Al composition in the HIL was optimized through theoretical calculations and experiments.


Background. Novel targeted therapies have demonstrated high efficacy in relapse and/or refractory (R/R) MCL. Ibrutinib, a first in class BTK inhibitor, is approved for R/R MCL. Venetoclax, a first in class bcl-2 inhibitor, is currently under investigation in prospective trials in R/R MCL. Obinutuzumab is a type II glycol-engineered, humanized anti-CD20 antibody approved in frontline and R/R follicular lymphoma which has shown efficacy in MCL (Chiron Blood 2016, Le Gouill ICML/EHA 2019). Pre-clinical investigations have demonstrated the utility of combining these three molecules in MCL (Chiron et al, Blood 2016) The OAsIs trial (NCT02558816) is a multicenter, non-randomised, phase I study that was designed to assess the safety, tolerability and efficacy of Ibrutinib/ Venetoclax/Obinutuzumab in both R/R MCL and in newly diagnosed MCL. The study is divided into three steps (A, B,C, respectively) : step A enrolled nine R/R MCL who were treated with Ibrutinib plus Obinutuzumab and step B enrolled 24 R/R MCL patients who were treated with Ibrutinib/Venetoclax/Obinutuzumab (Venetoclax dose from 200 to 800mg ). The Ibrutinib/Venetoclax/Obinutuzumab combination demonstrated a good safety profile and high response rates in R/R MCL (step B). No DLT was reported in either step (Le Gouill et al, ASH 2018). Herein, we present the safety (primary objective), clinical and MRD results for Oasis step C where Ibrutinib/Venetoclax/Obinutuzumab was given to newly-diagnosed, untreated MCL patients.
 Methods: Obinutuzumab was given at 1000mg IV C1D1, 8, 15, C2-6 D1 and every 2 months until C23. Ibrutinib was given as a standard dose (560mg/d) from C1D2 and until progression. The dose of Venetoclax was 400mg (according to step B analysis and DSMC recommendations) and administered from C1-bis (to prevent TLS: C1-bis W1-20mg, C1-bis W2-50, C1-bis W3-100, C1-bis W4-200) and at 400mg from C2 to C23. Response was assessed by cheson 99 criteria at C2, C4 and C6 and by Lugano criteria at Cycle 6. MRD by ASO-qPCR (assay sensitivity 10-5) was measured at the end of C3 and 6 in blood and / or bone marrow. DLTs were assessed during the first 3 months (C1, C1-bis and C2) of treatment.
 Results. Fifteen untreated MCL patients were enrolled from August 2018 to April 2019, in 6 participating centers (France and UK). Median age at inclusion was 65y (range 51-77). All patients presented with stage III/IV disease and nodal disease (four patients had tumor mass >5cm). The MIPI score was high in 9 cases, intermediate in 5 and low in one case. One patient presented with pleomorphic variant. TP53 status at diagnosis was assessed in 13 patients (one was not informative and two are ongoing) of these one presented TP53 mutation. IGHV status (assessed in 13 patients, ongoing in 2) was mutated in two cases including the p53mutcase and not mutated in 8 (not informative in 3 cases). During the first three months of treatment (C1, C1-bis and C2), the relative dose intensity (ratio of delivered to the planned dose intensity) was 87% for Ibrutinib, 93% for Obinutuzumab and 100% for Venetoclax. During this period, non-hematological grade 3-4 AEs were hepatobiliary disorders (n=4; 3 patients with raised GGT-grade 3-, alanine -grade 3- and aspartate -grade 4- aminotransferase and one with biological cytolysis - grade 4) and rash (n=1; grade 3). Hematological grade 3-4 AEs were lymphocytosis (n=1; grade 3) and neutropenia (n=1; grade 4). All (n=15) patients are in response (including CR/uCR in 7 cases) at end of cycle 2 according to Cheson 99 criteria. In terms of MRD status, 8 patients (others are ongoing) were assessed at end of cycle 3 and all were MRD negative in BM (n=6) and/or in blood (n=8), including the p53mutpatient. Seven patients completed 6 cycles, all reached CR according to Lugano criteria (6 in CR/Cru according to Cheson criteria) and were MRD neg (in blood in all cases and in BM in 6 cases -one not done), including the P53mut patient. At date of last monitoring (Jul 2019), no disease progression is reported and all patients remain under the planned treatment.
 Conclusion. Ibrutinib/Venetoclax/Obinutuzumab combination therapy has a very good safety profile and shows high efficacity rates at the molecular level in untreated patients. Oasis step C is the first trial that report the use of Ibrutinib/Venetoclax/Obinutuzumab as frontline therapy in MCL.

 Le Gouill: Janssen-cilag: Consultancy, Honoraria; Novartis: Consultancy; Abbvie: Consultancy, Honoraria; Roche Genentech: Consultancy, Honoraria; Gilead-Kite: Consultancy, Honoraria; Servier: Consultancy; loxo: Consultancy, Honoraria; Takeda: Consultancy. Morschhauser:Bayer: Membership on an entity's Board of Directors or advisory committees; Epizyme: Membership on an entity's Board of Directors or advisory committees; F. Hoffmann-La Roche Ltd: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria; BMS: Membership on an entity's Board of Directors or advisory committees; Gilead: Membership on an entity's Board of Directors or advisory committees. Bouabdallah:Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Roche: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees. Cartron:Roche, Celgene: Consultancy; Sanofi, Gilead, Janssen, Roche, Celgene: Honoraria. Chevallier:Jazz Pharmaceuticals: Honoraria; Daiichi Sankyo: Honoraria; Incyte: Consultancy, Honoraria. Rule:Janssen: Consultancy, Honoraria, Research Funding; Roche: Consultancy, Honoraria, Research Funding; Astra-Zeneca: Consultancy, Honoraria; Napp: Consultancy; TG Therapeutics: Consultancy, Honoraria; Sunesis: Consultancy, Honoraria; Gilead: Consultancy, Honoraria; Pharmacyclics: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Kite: Consultancy.

 Venetoclax, obinutuzumab in mantle cell lymphoma


This paper presents a subband acoustic echo canceller (SBEC) using two different analysis filters and an 8th order complex affine projection algorithm (APA). This SBEC uses different analysis filters to divide the input signals and echo signals. The analysis filter for the input signals is designed to improve the convergence speed, and the analysis filter for the echo signals is designed to achieve high echo return loss enhancement. This SBEC also uses an 8th order complex APA to further improve the convergence. We implemented the proposed SBEC on digital signal processors and evaluated it. The results show that our SBEC converges five times faster than the conventional SBEC.


This article indicates the leading place which America holds in the development of the psychological study of religion and then passes on to an account of the outstanding theories as to the psychological sources of religion; it describes the methods that have been devised to discover and interpret religious experiences and offers a survey of leading investigations into the primary phenomena of religion; it considers the significance of subconscious and of social factors in the development of religious ideas and activities and, in conclusion, offers suggestions for the critical evaluation of psychological studies of religion.


Recently, a novel approach for the estimation of the residual error parameters of a calibrated ve ctor network analyzer has been proposed. The method is based on a reflection measurement employing a high precision airline terminated by a short. From this measuremen t the complex valued residual error parameters are calcul ated utilizing a sophisticated data analysis scheme. In this work the uncertainty associated with the obtained residu al error parameters is evaluated. The uncertainty evaluation is performed by applying the GUM S1 approach employing a Monte-Carlo method. Resulting uncertainties arising due to imperfections of the dimensional parameters of the airline are presented.


Electromagnetic (EM) follow-up observations of gravitational wave events will help shed light on the nature of the sources, and more can be learned if the EM follow-ups can start as soon as the gravitational wave event becomes observable. In this paper, we propose a computationally efficient time-domain algorithm capable of detecting inspiral gravitational waves from coalescing binaries of compact objects with nearly no further delay in addition to the time required to condition the data into a time series of calibrated gravitational-wave strain. Our algorithm, if can be expanded to include sky localization, will serve as the first step towards triggering EM observation before the merger. The key to the efficiency of our algorithm arises from the use of chains of so-called infinite impulse response filters, which filter time-series data recursively. Computational cost is further reduced by a template interpolation technique that requires filtering only done for a "coarse bank", much sparser than the "fine bank" normally required to sufficiently recover the optimal signal-to-noise ratio: the filter chain of each coarse-bank template is divided into several sections, filtering output from these sections are combined appropriately to reconstruct the output of each of the nearby fine-bank templates. The filter construction and interpolation techniques are illustrated in this paper using Newtonian-chirp waveforms, although these will be generalizable to more accurate post-Newtonian waveforms. Towards future detectors with sensitivity extending to lower frequencies, our algorithm's computational cost is shown to increase rather insignificantly compared to the conventional time-domain correlation method using finite impulse response filters.


Abstract. New results are presented on the effects of mono‐ and divalent cations on concurrent changes in the microsecond yields and kinetics of chlorophyll a fluorescence and delayed light emission, and the light saturation curve for the latter at 100 μs, following a 10 ns flash at 337 nm. (1) The fluorescence yield increases exponentially from 3 to 30 μs (lifetime, τ, 6.4 ± 0.6/μs), and decays biphasically between 50 and 800μs. (2) The delayed light emission decays biphasically with two exponential phases: fast phase, T= 7–10μs, and slow phase, T= 33–40μs. (3) The light saturation curve for 100μs delayed light emission is satisfactorily represented by a one‐hit Poisson saturation curve. (4) Addition of 5 mM NaCl to salt‐depleted chloroplasts decreases (by as much as 40%) the yields of μs fluorescence and delayed light emission, and the subsequent addition of 5mM MgCl2 increases the yields (≤2 × over samples with only NaCl). (5) The fluorescence yield rise and delayed light emission decay kinetics are independent of low concentrations of cations. The lifetime of the fast phase of fluorescence decay changes from ˜90μs to ˜160μs, when Na+ or Na++ Mg2+ are added.


This paper describes conducted Electromagnetic Interference (EMI) simulation of a buck converter using a compact model for an SiC-MOSFET. The model simulates the peak values of leakage current flowing out of a heatsink ileak accurately since the model reproduces the experimental results of drain-source voltage and its time derivative. In addition, the simulated spectrum of conducted disturbance voltage is in good agreement with the experimental one up to 20 MHz within a maximum error of 6 dB. From 20 to 30 MHz, the simulated spectrum shows the similar peak values to the experimental one with a little deviation in the resonant frequency. The simulated results indicate that the model would be a promising tool for conducted EMI analysis of the power converters using SiC-MOSFETs.


The magnetite hypothesis is one possible explanation for how a putative magnetoreceptor might function, and is based on neuronal activation by intracellular nanoparticles of magnetite (Fe3O4) [1]. This is expected to occur when torque is applied to the membrane anchored particles of magnetite in response to changes in Earth-strength magnetic fields. Magnetotactic bacteria provide good evidence for the magnetite hypothesis in animals as they are able to produce chains of magnetite nanoparticles (magnetosomes) in their cytosol (Fig. 1A) and use them for orientation in the Earth's magnetic field.