The article is devoted to the consideration of the main directions of digital transformation of the transport industry in Russia.
It is proposed in the process of digital transformation to integrate the community approach into the company's business model using blockchain technology and methods and results of data science; complement the new digital culture with a digital team and new communities that help management solve business problems; focus the attention of the company's management on its employees and develop those competencies in them that robots and artificial intelligence systems cannot implement: develop algorithmic, computable and non-linear thinking in all employees of the company.


The need for finding a set of plans rather than one has been motivated by a variety of planning applications. The problem is studied in the context of both diverse and top-k planning: while diverse planning focuses on the difference between pairs of plans, the focus of top-k planning is on the quality of each individual plan. Recent work in diverse planning introduced additionally restrictions on solution quality. Naturally, there are application domains where diversity plays the major role and domains where quality is the predominant feature. In both cases, however, the amount of produced plans is somewhat an artificial constraint, and the actual number has


Abstract The phase diagram in parameter space of the Double Chain Model for the existence of the phason gap is calculated. Results for different interchain potentials are compared. The modulation function and the phason mode are studied.


Solubility of polymethyl methacrylate in 12 organic solvents at 30 70 C was studied. The resistance of polymers to organic solvents is theoretically and practically important. At the same time, studies in this area are mainly concerned with swelling of polymers in various media. The dissolu- tion process itself, despite its wide application in var- ious technologies, has been studied to a considerably lesser extent. According to the Nernst diffusion theory, the dis- solution of low-molecular compounds in liquids oc- curs at the phase boundary rapidly and is limited by diffusion of components toward and away from the surface of a solid. The process rate v is determined by the diffusion coefficient D, boundary layer thick- ness l, and difference of the solute concentrations in the surface layer (c0) and in the bulk (c):


Ultralow molecule weight partly bydrolytic polyacrylamide was synthesized by radical polymerization using thi-ol as a chain transfer agent;then modified polyacrylamide was prepared by ring-opening reaction of glycidyl methacrylate with above synthesized polyacrylamide,and characterized by 1H-NMR. After that a new nontoxic water-soluble polyacrylamide grouting material was prepared by using water-soluble redox system and adding other reagent,and compared its property with that of acrylamide grouting material.The result shows that the modified polyacrylamide grouting material is an environmental protective grouting material with excellent performance.


In this article, the author surveyed senior level management majors, management professors, and campus recruiters to investigate the criteria used by the students in selecting desirable positions for employment and the accuracy of management professors' and corporate recruiters' perceptions of those criteria. The author identified the criteria and found that professors and recruiters were not highly accurate in identifying these variables.


1538 Background: The role of chemotherapy (CT) in the treatment of malignant gliomas is still debated. Different chemotherapeutic agents are currently used with modest impact on survival. At the mo...


CONICYT through the FONDECYT grant; Ministry of Economy, Development, and Tourism's Millennium Science Initiative,; Danish Agency for Science and Technology and Innovation realized through a Sapere Aude Level 2 grant; Gemini Observatory


The long subtitle of this paper, appearing in the first issue of the EJRR – a publication which fills a serious gap in the scholarly literature of the old continent – identifies what I take to be the key terms of the current debate on risk regulation. It is impossible to understand the evolution of risk regulation over the last three decades in Europe and the United States without having a good grasp of how these concepts, and their corresponding practices, interact. How, for example, does a particular institutional design affect the way scientific uncertainties are resolved? What decision rules are appropriate in situations of high scientific uncertainty? Which constitutional principles facilitate policy learning and accountability in the regulation of risk?


Background: Obesity is associated with heart failure, cardiovascular morbitity, and mortality. A direct effect of weight on left ventricle (LV) structure and myocardial function is not well‐established. Aim: The aim of our study is to determine the effect of obesity on LV morphology and systolic function by using LV standard Doppler echocardiographic indices, myocardial Doppler imaging and strain/strain rate imaging indices. Methods: We studied 33 obese and 34 age, sex‐adjusted control subjects who had no other pathological conditions. Standard transthorasic Doppler echocardiographical measurements, reconstructed spectral pulsed wave tissue Doppler velocities, strain and strain rate imaging of six different myocardial regions were obtained. Peak systolic velocity (SR), peak systolic strain (Î), peak systolic strain rate (SR) for each region and as a global systolic longitidunal LV function mean of peak systolic strain of six myocardial regions (glsca) were compared. Results: Age, body surface area, blood pressure, and heart rate were comparable between the two groups. Obese subjects had significantly increased LV end‐diastolic volume, septal wall thickness, left atrial diameter, and decreased transmitral early to late diastolic velocity ratio. In obese subjects, reconstructed spectral pulsed‐wave tissue Doppler analysis showed significantly decreased basal lateral peak systoic (Sm) velocity (6.68 ± 1.89 vs. 8.08 ± 2.50, P < 0.05), mid lateral Sm (5.01 ± 2.17 vs. 6.78 ± 3.22, P < 0.05). Differences in regional strain rate (mid septal SR, 1.45 ± 0.23 vs. 1.63 ± 0.18, P < 0.05), regional strain (basal septum Î, 19.13 ± 3.83 vs. 22.09 ± 4.60, P < 0.05; mid‐septum Î, 18.03 ± 2.91 vs. 20.25 ± 4.77, P < 0.05; radial Î, 27.50 ± 7.32 vs. 35.53 ± 9.48, P < 0.05), and global strain (glsca, 19.38 ± 1.34 vs. 21.24 ± 2.82, P < 0.05) were identified between obese and the referent subjects. Conclusions: Obesity is associated with morphologic alterations in left ventricle and left atrium and subclinical changes in left ventricle systolic function which can be detected by strain and strain rate imaging even without overt heart disease.


Background Knee osteoarthritis (OA) is the most common disease of joints in older adults around the world. It is a chronic condition associated with pain and reduction in physical function, leading to a negative impact on the physical and psychosocial well-being of patients. Therefore, different instruments have been developed to evaluate the impact of OA on functioning and quality of life of patients2 Objectives To determine the association between subjective and objectivemeasuring tools of knee osteoarthritis patients enrolled in Spanish primary care Methods 120 patients with radiologically confirmed knee osteoarthritis. The following scores were calculated and recorded for logistic regression analysis: Visual Analogue Scale (VAS) for pain, Western Ontario and McMaster Osteoarthritis Index (WOMAC) for functional status, and EQ-5D for Health related quality of life, radiographic severity measured by Kellgren-Lawrence grade (K/L), age and Body Mass Index (BMI) Results An 80% of the sample were women, mean (SD) age 64,11 (10,361) and BMI 31,40 kg/m2 (5,3). Radiographic severity mean (SD) was 2, 63 (0,685) and 75% had more affected joints besides knee. Mean (SD) standardized tools scores were: EVA 6,46 (2,3 SD); EQ-5D 0,58 (0,23); EQ-5D VAS 56,6 (16,9); WOMAC pain 8,97 (3,7); WOMAC stiffness 3 (2); WOMAC function 29,5 (12,8) and WOMAC global 41,5 (16,86). No significant association between radiographic severity and subjective health statewas finding. Age and BMI were not correlated either, although older people had worse radiologic severity (p=0,002), and fattest people had more pain and stiffness measured by WOMAC index EVA EQ-5D WOMAC pain WOMAC stiffness WOMAC function K/L NS NS NS NS NS BMI NS NS 0,188* 0,180* NS AGE NS NS NS NS NS *p<0.05; NS: non-significant (p>0,05). Conclusions This sample shows that radiographic severity does not match with knee symptomatology as other studies have previously assert. Just WOMAC index was correlated with objective measures. Further studies could inquire why higher BMI is associated with worse stiffness and pain scores in WOMAC index but does not impact in people function References Tsonga T, Kapetanakis S, Papadopoulos C, Papathanasiou J, Mourgias N, Georgiou N Open Orthop J Xie F, Pullenayegum EM, Li SC, Hopkins R, Thumboo J, Lo NN Value Health Disclosure of Interest None Declared


The purpose of this study was to measure voice analysis to improve intellectually disabilities children's physical activity and communicative ability through an ART physical activity program. To attain the goal, the study had as its subjects total 16 intellectually disabilities children attending a special-education school located in Busan, 8 for the experimental group and another 8 for the control group. With the result of the armband and voice analysis on the intellectually disabled children participating in the ART physical activity program, the study drew the following conclusions: First, regarding the physical activity change, there was significant difference in the result of analysis on total energy consumption between groups, and the group participating in the program showed higher total energy consumption than the group not participating in it. Second, there was significant difference in MET analysis result between groups, and the group participating in the program indicated more improved MET than the group not participating in it. Third, there was significant difference in Fo analysis result between groups, and the group participating in the program showed higher Fo ability than the group not participating in it. Fourth, there was significant difference in MPT analysis result between groups, and the group participating in the program indicated more improved MPT ability than the group not participating in it.


The perdeuterated 1:1 complex of parabanic acid (C3D2N203) and urea (CD4N20) at 116 K is monoclinic, space group P21/c, with a = 8.910 (3), b = 5.597 (2), c = 14.525 (6) A, fl = 108.39 (3) °, and has four molecules of each kind per unit cell. The nuclear configuration has been determined from 2165 neutron intensities (sin 0/2 < 0.76 A -I, 2 = 1.0450 A) to give e.s.d.'s in apparent bond lengths and angles of 0-001 ,/k and 0.1 °, or less. The configurations of the two molecules are similar to those found in their separate crystal structures, but there are small differences, which appear to be related to the different hydrogen bonding. There is an unusually short hydrogen bond (N . . .O , 2.66 /k) between parabanic acid N D and urea O atoms. There are also short C . . . O distances (2.81, 2.86 A) between carbonyl groups of different parabanic acid molecules. The polar molecular interactions of parabanic acid are similar to those of the drug-active barbiturates.


Bangladesh is an agricultural country which gets most of its income through this sector. Most of its people live off agriculture. Despite this huge involvement of general people in this sector, it has been seen that agriculture is the main driving force of poverty since 2000. The farmers remain in distress due to the huge price margin between producers and end users caused by middlemen. Asymmetric information happens to affect the whole supply chain, proving agriculture marketing to be the biggest challenge to small-scale farmers. Another factor that is to be blamed is the lack of control by the government in the price gap. In order to have a direct overview of this scenario, this study has been conducted in Savar, which is one of the most popular agricultural regions of Dhaka City. A total of 55 respondents agreed to participate in this survey. Study shows that most farmers were more than 38 years old and the main bread earners in their families.  It was revealed through the farmer that there is no control of the government in the high price charged by middlemen. Farmers also sold off their goods to middlemen at cheap prices which wasn't monitored by the government either. This may also turn out to be a economic risk in future as it implies to wastage of agricultural resources.


Edible by-products are a good source of nutrients and bioactive substances and could be used as functional ingredients or for biopeptides production natively contained in raw materials. A wide range of peptides are also formed during the enzymatic hydrolysis or food processing. The comparative results of the effectiveness of isolated certain protein and peptide fractions by ultrafiltration with the same natively presented in raw tissues, as well as the influence of heat treatment on biological activity of origin active substances are presented. The model of rat alimentary hyperlipidemia was developed by adding cholesterol and fat to the standard diet and vitamin D2 injection per os. Serum lipid profile was determined on automatic analyzer BioChem FC-360. Dynamic of changes in serum lipid profile was assessed as corresponding control group medium results in ratio to certain rat data. Two-dimensional electrophoresis (2DE) was performed according to the method of O'Farrell with isoelectric focusing in ampholine pH gradient (IEF-PAGE) with following identification by MALDI-TOF MS and MS/MS mass spectrometry. Consumption of native pig aorta and pig heart during 14th days led to normalization of lipid profile in serum of hyperlipidemic rats, while low molecular weight (LMUF, MW <5 kDa) and medium molecular weight (MMUF, MW = 5 – 30 kDa) ultrafiltrates of pig aorta extract did not strongly influenced on level of triglicerides and, on contrary, elevated high density cholesterol. Consumption of developed product by hyperlipidemic rats during 28th days did not lead to significant changes in serum lipid profile, while on 42nd day all ratios reached ones in group, which were treated with native raw material or isolated active fractions. The stability of developed product was confirmed by proteomic studies. Obtained results open prospects to modernization the technology, presumably use as a matrix dietary meat (e.g. poultry) with incorporated active identified components.


Abstract : Lactate levels have been found to correlate with the severity of injury, including hemorrhage and whole body hypoxia. The ability to monitor in vivo lactate in the interstitium is possible but current methods are either not clinically feasible for prolonged measurement or are unreliable because they suffer from deleterious effects of endogenous interference and fouling.


Using data from the Regional Education Office of Medan City and triangulating with Policy Actor from North Sumatera Education Quality Assurance (BPMP Sumut), this study explores the Learn From Home (BDR) Policy implementation in Medan City during the Academic Year of 2020-2021 with a qualitative assessment referred to guidelines from the Indonesia Ministry of Education, Culture, Research, and Technology (MoECRT) Minister Circular Letter No. 04/2020 and Secretary General Circular Letter No. 15/2020. Findings indicated that during the Academic Year of 2020-2021, 88% of Primary students participated in BDR Online (Daring), while 12% in BDR Offline (Luring), with a case of 786 untracked students in two sub-districts. Public Schools tend to have higher Student-Teacher ratios than Private Schools. Across sub-districts in Medan City, 75% (10,010 teachers) are Honorary teachers, and 25% (3,311 teachers) are State Civil Workers (ASN). Collectively, the Total of Students per Study Group (Rombongan Belajar/rombel) follows the Minister of Education and Culture Regulation No. 22/2016 concerning Process Standards for Primary and Secondary Education with a ratio of students-rombel between 21 to 28. At Public Schools, the ratio of students-rombel is slightly exceeded the suggested ratio, with the total number of students per rombel between 22-29. However, the findings mainly vary when comparing schools in the same sub-district or across the sub-district. Based on qualitative assessment findings indicated that Learn from Home (Belajar Dari Rumah) Policy implementation was misaligned in two areas; (1)Data collection on students' BDR situation and (2) students' admission (PPDB) mechanism.


Polynomial multiplication is one of the most time-consuming operations utilized in lattice-based post-quantum cryptography (PQC) schemes. CRYSTALS-KYBER is a lattice-based key encapsulation mechanism (KEM) and it was recently announced as one of the four finalists at round three in NIST's PQC Standardization. Therefore, efficient implementations of polynomial multiplication operation are crucial for highperformance CRYSTALS-KYBER applications. In this paper, we propose three different hardware architectures (lightweight, balanced, high-performance) that implement the NTT, Inverse NTT (INTT) and polynomial multiplication operations for the CRYSTALS-KYBER scheme. The proposed architectures include a unified butterfly structure for optimizing polynomial multiplication and can be utilized for accelerating the key generation, encryption and decryption operations of CRYSTALS-KYBER. Our high-performance hardware with 16 butterfly units shows up to 112×, 132× and 109× improved performance for NTT, INTT and polynomial multiplication, respectively, compared to the high-speed software implementations on Cortex-M4.


We respectfully disagree with their assertion and would like to offer the following explanation to substantiate our claims. Their article described the sono-anatomy of the sciatic nerve and a technique of performing ultrasound-guided sciatic nerve injection at the infra-gluteal location in volunteers. By definition, 'infra-gluteal' is inferior to the gluteal crease. Therefore, an infra-gluteal injection for sciatic nerve block is performed inferior to a line joining the greater trochanter and the ischial tuberosity. 4 Figure 1B in their article illustrates the location at which the infra-gluteal ultrasound scan and injection is performed. In the technique that we describe, the ultrasound scan and needle insertion is performed above the gluteal crease and directly over a line joining the lateral prominence of the greater trochanter and the ischial tuberosity. Although the two techniques may appear similar, because they are both 'sub-gluteal' injections, that is, under the gluteus maximus, and both injections are made in relation to the greater trochanter and the ischial tuberosity, there are subtle anatomical differences that make these two techniques different. In the technique that we describe, the 'sub-gluteal space', which is a well-defined anatomical space and contains the sciatic nerve, is initially identified on the ultrasound image as a hypo-echoeic area between the hyper-echoeic perimysium of the gluteus maximus and the quadratus femoris muscle. Distention of the subgluteal space to a test injection of saline through the block needle is then confirmed—'our end point', irrespective of whether a motor response to nerve stimulation is elicited in the foot or not, before the local anaesthetic is injected. In contrast, Chan and colleagues perform their ultrasoundguided subgluteal injection in the infra-gluteal position after identifying the sciatic nerve using nerve stimulation. There is no mention by Chan and colleagues as to whether they were able to identify a potential perineural space on the ultrasound image of the infra-gluteal area before the local anaesthetic injection, although they report enlargement of the space after the injection. We were able to identify pulsations of the inferior gluteal artery medial to the sciatic nerve in the 'subgluteal space' whereas Chan and colleagues were unable to identify any blood vessel in the vicinity of their injection confirming that our two techniques were performed at different locations. Moreover, local anaesthetic also spreads between different muscles in the two techniques. In our technique, the local anaesthetic spread between the gluteus maximus and the quadratus femoris muscle. In comparison, in the infra-gluteal technique, it spreads between the gluteus maximus and biceps femoris muscle posteriorly and the adductor magnus muscle anteriorly. We agree that the above discussion should have been included in our report and hope that it will help clarify the differences between our technique and the technique of ultrasound-guided subgluteal sciatic nerve block at the infra-gluteal position.


A novel D flip-flop for low voltage operation with improved speed is proposed using SPICE simulation, which takes advantage of a dynamic threshold voltage MOSFET featuring ultra-low voltage operation and a negative differential resistance storage featuring less capacitance.


Ranging over all George Eliot's fiction and drawing as well on her letters, essays, and translations, in this book the distinguished critic Neil Hertz documents Eliot's lifelong questioning of the nature of authorship and of what it might mean, in the language of one of her early letters, for her "not simply to be, but to utter." Pursuing oddities of diction and figuration, of plotting and characterization, Hertz finds everywhere in Eliot's works passages of high mimetic realism that ask to be read as allegories of writing or as characters whose actions and destinies can only be understood if they are seen as disguised surrogates of their author. Each essay begins with an intriguing or problematic bit of language, then moves about within a particular work of fiction or criss-cross to other writings of Eliot's as well as to works by philosophers, psychoanalysts, and literary theorists.


World heritage site management and evaluation has not been paid enough attention to for lack of evaluation indicators in China. The paper establishes the evaluation system including the indicators of heritage protection, heritage usage contribution to the society, heritage usage contribution to the host community's economy. The indicators are applied to evaluate the world heritage Wulingyuan, it argues that Wulingyuan's governance is at the level of low efficiency.


Carbon dioxide COncentrations were measured at various depths and times in the unsaturated zones of two hydraulically and geochemically contrasting field sites, one in southeastern Washington state, and the other in south central Saskatchewan. In situ CO, production rates were calculated from a mass balance that accounted for diffusive fluxes and partitioning of CO[sub 2] into an advecting aqueous phase. Production rates were compared with (1) microbial abundance and (2) subsurface temperature to determine whether subsurface CO[sub 2] production rates could be expressed as a simple function of these two variables. At the Washington site, subsurface production was successfully expressed as a function of microbial abundance and temperature for a large portion of the year, but not near the end of the growing season. Although subsurface microbes and organic carbon were more abundant at the Saskatchewan site, subsurface CO[sub 2], production rates were generally several orders of magnitude lower than at the Washington site, and no correlation could be established between microbial numbers, temperature, and production rate. The cases where production rates could not be expressed as a function of microbial numbers and temperature suggested conditions in which some other factor, such as nutrient limitations, was controlling.


We study the spatial properties of the Casimir friction phenomenon for an atom moving at a non-relativistic constant velocity parallel to a planar graphene sheet. The coupling of the atom to the vacuum electromagnetic (EM) field is implemented by an electric dipole term, plus a R\"ontgen term. We study the fermion pair production, evaluating the angular dependence of the fermion emission probability. The phenomenon exhibits a threshold: it only exists when the speed of the sliding motion is larger than the Fermi velocity of the medium.


1. The normal pattern of social behaviour in growing Large White and Berkshire pigs is described. The pigs were observed from 8 to 16 weeks of age in pens of 6 to 10 pigs. Large Whites were more aggressive than Berkshires. 2. Social rank was found to be positively correlated with initial weight. 3. Initial weight and social rank both influenced growth; the relative effect of rank compared with that of initial weight was greater in the second month than in the first. 4. The contribution of social rank to the total variance in growth over the 2-month period was estimated at about 13%. 5. It is suggested that the use of individual housing in pig progeny test schemes may not be desirable because of the absence of social environmental effects.


. The aims of this study were to: (1) find out whether the learning outcomes of the group of students taught with the Quizizz learning media were higher than the group of students taught with the Power Point learning media, (2) to determine whether the cultural arts group of students with high critical thinking skills has better learning outcomes than the group with low critical thinking skills, and (3) find out whether there is an interaction between Quizizz learning media and Power Point learning media with critical thinking skills in influencing cultural arts learning outcomes.The research population was all students of class X IPS MAN 2 Model Medan consisting of 5 classes. The samples chosen to be the Quizizz media learning class were class X IPS-4 and class X IPS-3 as the Power Point media learning class. Cluster random sampling is the method of sampling.The Scheffe test is used after the two-way ANOVA with a significance level of = 0.05.The outcomes revealed (1) Students' arts and culture learning outcomes were higher when they were taught with the Quizizz learning media than when they were taught with the Power Point learning media. Students who were instructed using Quizizz learning materials had an overall higher average learning outcome (=28.41) than students who were instructed using Power Point learning materials (=26.79); (2) In the cultural arts, students with strong critical thinking skills perform better than students with weak critical thinking skills.;(3) There is a connection between critical thinking abilities and learning media:Power Point learning materials are superior to Quizizz learning materials for students with low critical thinking abilities, whereas Quizizz learning materials are superior for students with high critical thinking abilities. In this case, the average learning outcomes of students with high critical thinking abilities who are taught with Quizizz learning media and Power Point learning media are higher than the average learning outcomes of students.


Armillaria rhizomorphs consist of differentiated hyphae with a melanized outer cortex. Melanin is known to prevent lysis of fungal structures by hydrolytic enzymes and may protect against antagonistic microorganisms. Our studies indicate that melanized rhizomorphs also adsorb high concentrations of cations from the surrounding soil environment. Rhizomorphs of four Armillaria species (A. ostoyae (Romagn.) Herink, A. calvescens Berube & Dessureault, A. gemina Berube & Dessureault, and A. sinapina Berube & Dessureault) collected from Minnesota, New Hampshire, and Oregon had substantially elevated levels of metal ions compared with the soil from which they were collected. With some elements, ions were 50–100 times more concentrated on rhizomorphs than in soil. Concentrations of Al, Zn, Fe, Cu, and Pb on rhizomorphs ranged up to 3440, 1930, 1890, 15, and 680 μg/g, respectively. Energy dispersive X-ray microanalysis showed that metal ions were located only on the outer portions of the rhizomorphs and not concen...


ABSTRA C T We present details of a large X-ray flare in the blazar 3C 279 detected during a 3-week period of daily observations by the satellite RXTE in early 1996. The flare lasted for a total of 7 d. The shape of the flare is well described by a symmetrical, exponential rise and fall with e-folding time-scales in each case of 1.1 d. The peak measured flux is three times the quiescent level. The flare is superimposed on a well-defined quiescent level and appears to represent a separate emission component. There is no statistically significant variability of the X-ray spectral index during the observations, but the errors are large and the data hint at a hardening of about 0.1 at the peak of the flare. Such a hardening is required to allow the X-ray flare spectrum to join on, in a single power law, to the g-ray flare that occurred at the same time. The exponential rise and decay most likely correspond to a variation in the acceleration of relativistic electrons or in the flux of seed photons, if the latter do not originate in the jet, as the energy loss time-scales are shorter than the rise and decay time-scales and the flare profile does not match that expected if light-travel delays determine the light curve.


Bacterial diversity was studied in the rhizosphere of Suaeda japonica Makino, which is native to Suncheon Bay in South Korea. Soil samples from several sites were diluted serially, and pure isolation was performed by subculture using marine agar and tryptic soy agar media. Genomic DNA was extracted from 29 pure, isolated bacterial strains, after which their 16S rDNA sequences were amplified and analyzed. Phylogenetic analysis was performed to confirm their genetic relationship. The 29 bacterial strains were classified into five groups: phylum Firmicutes (44.8%), Gamma proteobacteria group (27.6%), Alpha proteobacteria group (10.3%), phylum Bacteriodetes (10.3%), and phylum Actinobacteria (6.8%). The most widely distributed genera were Bacillus (phylum Firmicutes), and Marinobacterium, Halomonas, and Vibrio (Gamma proteobacteria group). To confirm the bacterial diversity in rhizospheres of S. japonica, the diversity index was used at the genus level. The results show that bacterial diversity differed at each of the sampling sites. These 29 bacterial strains are thought to play a major role in material cycling at Suncheon Bay, in overcoming the sea/mud flat-specific environmental stress. Furthermore, some strains are assumed to be involved in a positive interaction with the halophyte S. japonica, as rhizospheric flora, with induction of growth promotion and plant defense mechanism.


Objectives:  Current methods in assessing von Willebrand factor (VWF) ristocetin cofactor activity for Von Willebrand's disease (VWD) diagnosis include platelet agglutination by aggregometer or macroscopic slide examination, which are both time‐consuming with suboptimal interassay and intra‐assay variation. The purpose of this study is to establish a sensitive assay to detect VWF:RCo activity and evaluate its performance in VWD diagnosis.


It is important to identify new and practical ways of improving air quality in pig sheds to reduce the incidence and severity of respiratory diseases, improve production efficiency and animal welfare, and reduce the potential Occupational Health and Safety (OH&S) problem arising from long-term human exposure to airborne pollutants in piggery buildings (Donham et al. 1989). Although several strategies are already available to improve air quality in piggery buildings (Cargill and Skirrow 1997), the use of ozone has not been extensively investigated in pig production in Australia. Ozone is widely used to extend the storage life of various agricultural products, by reducing the bacteria load in food storage facilities (Ricel et al. 1982).


A review was made on alfalfa cold resistance in China based on summarized and analiyzed achievements of research on morphology,physiology and biochemistry and fall dormancy of alfalfa under low temperature stress.And the application of modern biological technology,radiation and space mutation of alfalfa cold-tolerance was summarized as well.The deficiencies and research prospect of alfalfa was discussed.


This paper develops a general equilibrium model with a vertical production structure to examine the relationship between offshore outsourcing and international migration,especially emphasizing their effects on the wages of skilled and unskilled workers. Two-way outsourcing (simultaneous insourcing and outsourcing) in skilled-labor intensive services arises due to product differentiation and scale economies, and outsourcing in unskilled-labor intensive processing occurs because of factor endowment differences. The tractability of the model allows us to rank outsourcing and migration, according to the wages of both types of workers. Finally, we also analyze under what conditions outsourcing and international migration are complements or substitutes.


OF in the the 326,000,000 oceans, air, and cu mi continents, of water in the ocean , air, and co tinents, less than 1 per cent is available as fresh water for use by man. And manyregions of the globe are struggling with inequities of rainfall. This situation has emerged within this decade as an important national concern. Scores of congressional committees and federal executive agency groups have been busy with studies, evaluations, hearings, and debates on the subject of water. Their concern has focused on what should be done to insure a sufficient water supply to encourage economic growth and human well-being in the United States and the world. The determination of measures to be


We report the first quantum-key-distribution (QKD) systems capable of delivering sustainable, real-time secure keys continuously at rates exceeding 10 Mb/s. To achieve such rates, we developed high-speed postprocessing modules, achieving maximum data throughputs of 60 MC/s, 55 Mb/s, and 108 Mb/s for standalone operation of sifting, error correction, and privacy amplification modules, respectively. The photonic layer of the QKD systems features high-speed single-photon detectors based on self-differencing InGaAs avalanche photodiodes, phase encoding using an asymmetric Mach–Zehnder interferometer, and active stabilization of the interferometer phase and photon polarization. An efficient variant of the decoy-state BB84 protocol is implemented for the security analysis, with a large dataset size of $10^8$ bits selected to mitigate finite-size effects. Over a 2-dB channel, a record secure key rate of 13.72 Mb/s has been achieved averaged over 4.4 days of operation. We confirm the robustness and long-term stability on a second QKD system continuously running for 1 month without any user invention.


Objective: To investigate the utilization of medical rehabili-tation services and the degree of satisfaction about rehabilita tion services in patients with brain disorders.Method: A total of 1903 patients agreed to participate in this study and were interviewed from September 2005 to May 2006. The subjects completed the questionnaires about the utilization of medical rehabilitation services and the degree of satisfaction with those treatments. Pearson's chi- square test, Student t-test and frequency analysis were used for statistical analysis. Results: A 78.0 percent of patients received inpatient rehabili-tation treatment. A 66.9 percent of all patients were served of only physical therapy and 31.6 percent received both physical and occupational therapy. The main reason why patients could not have a chance to experience rehabilitation treatment was associated with environmental problems, such as the ignorance of the need about rehabilitation treatment, or the insufficient communication between doctors and patients. Most patients (54.6%) were satisfied with the rehabilitation treatment. However, as the number of admission was increased, patients tended to be less satisfied with the rehabilitation treatment.Conclusion: The inpatient rehabilitation treatment was limitedly served to patients with brain disorders mostly when the patients required rehabilitation services. It is nece-ssary to provide more effective and various rehabilitation services to patients under the comprehensive guideline of the process of rehabilitation services. (J Korean Acad Rehab Med 2010; 34: 297-303)Key Words: Disabled by brain disorders, Rehabilitation, Satisfaction서론


The spring rapeseed variety Erebus was developed in 2007–2018 by individual selection in F2 from the hybrid combination LK-443-04 × LK-654-06. Ac-cording to the competitive variety trials conducted by the All-Russian Research Rapeseed Institute during 2013-2018, variety Erebus had better results than standard variety Rif in seed yield by 0.12 t/ha or 5.8% and in oil yield the results were higher by 0.08 t/ha. The content of glucosinolates in the seeds was 2.8 µmol/g lower than that one of variety Rif. In 2022, Erebus has been included in the National List of Varieties (Patent № 11441) and approved for pro-duction use in the Central (3), Volga-Vyatsky (4), Central Chernozem (5), Middle Volga (7), Ural (9), West Siberian (10), East Siberian (11) and Far East (12) regions of the Russian Federation.


This paper examines the long-term effects of lynching Black offenders in the United States during the 19th and 20th centuries on current local rates of Intergenerational mobility for Blacks. I find that higher historical lynching activity at the local level is associated with lower rates of intergenerational mobility. Moreover, I provide suggestive evidence that lynching activity spread prejudice, racism, and hate for Black people, thus negatively affecting their economic opportunities. Several robustness checks support the validity of my results.


Direct shear test is a traditional method for the measure of coarse-grained soils strength indexes,but the testing apparatus has significant technical defects,which not only cause shear area gradually reducing,the center position of shear surface gradually offsetting,with the occurrence and development of shear displacement,but also normal stress increasing and irregularly distributing on shear surface.In order to overcome these defects,a new direct shear testing apparatus for large coarse-grained soils was developed,by using the framework of gear and rack to fix the position of shear area,and by using equalizing technic of linear ratio pressure adjustment to keep the normal stress from varying.


There was no correlation between the inflammatory response and the degree of oxygen impairment. Discussion: Impaired oxygenation is progressively increased after cardiac surgery independent of the temperature during CPB. A well-defined inflammatory response did not correlate to the degree of postoperative impaired oxygenation. References: 1 Singh NP, Vargas FS, Cukier A, et al. Arterial blood gases after coronary artery bypass surgery. Chest 1992; 102: 1337–1341. 2 Kjærgaard S, Rees SE, Grønlund J, et al. Hypoxaemia after cardiac surgery: clinical application of a model of pulmonary gas exchange. Eur J Anaesthesiol 2004; 21: 296–301.


Missense mutations can change protein structure, cellular localization, and functions. Such changes lead to the rewiring of protein-protein interaction (PPI) networks, activation of oncogenic pathways, and acquisition of cancer hallmarks. However, the translation of the landscape of oncogenic mutations into clinically actionable biological models for cancer target discovery remains a major challenge. We address this challenge by leveraging the power of computational systems biology supported by high-throughput screening technologies. While some mutations can disrupt the PPIs, others may induce new PPIs that are not natural for the wild-type counterparts. Recently, we have established a quantitative High Throughput differential Screening (qHT-dS) platform [1] to discover such mutant-enabled or neomorph PPIs (neoPPIs). The screening of more than 13,000 mutant interactions revealed a landscape of gain-of-interactions encompassing both oncogenic and tumor suppressor mutations. This emerging neoPPI landscape may offer new mutant-directed therapeutic approaches for precision medicine. However, to infer clinically actionable mechanistic insights into how neoPPIs promote tumorigenesis special computational tools are needed. To inform the neoPPI-based target discovery, we develop a set of innovative informatics tools for discovering Actionable Vulnerabilities Enabled by Rewired Oncogenic Networks (Averon). Implemented in a widely-used Jupyter Notebook format, the Averon streamlines the identification of the oncogenic programs and clinically significant genes that are regulated by neoPPIs in cancer patients. The Averon can recapitulate well-established connectivity between known mutant-dependent PPIs and specific oncogenic pathways and reveal new, previously unknown mechanisms of neoPPI-mediated oncogenic signaling. To inform new therapeutic strategies in neoPPI-dependent cancers, Averon connects neoPPI-regulated genes with available approved drugs and clinical compounds. Together, the Averon provides a powerful informatics environment to determine therapeutically actionable vulnerabilities created by mutant-regulated protein-protein interactions to inform new personalized therapeutic strategies in cancer.
 Acknowledgments: This work was supported in part by NCI's Informatics Technology for Cancer Research (ITCR) Program (R21CA274620, A.A.I.), Winship Cancer Institute #IRG-17-181-06 from the American Cancer Society (A.A.I.). Cancer Target Discovery and Development (CTD2) Network (U01CA217875, H.F.), NCI Emory Lung Cancer SPORE (P50CA217691, H.F.), Career Enhancement Program (A.A.I., P50CA217691), Winship Cancer Institute (NIH 5P30CA138292).
 References: 1. Mo X, et al., Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. Cell. 2022, 185, 1974-1985.
 Citation Format: Andrey A. Ivanov, Haian Fu. Averon: informatics platform to discover Actionable Vulnerabilities Enabled by Rewired Oncogenic Networks. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4275.


The National People and Pets Survey (Australian Companion Animal Council, 2010)
◦ 63.3% of Australian households owned a pet
◦ 92% of respondents felt "very close" to their pet
◦ 86% of respondents found comfort with their pet during times of stress,
◦ 62% of respondents felt their pet made for a friendlier environment and helped with conversation between humans


The influence of the noble gas mixture composition on the plasma display panel performance is investigated in test panels with a design which resembles the one used in commercial panels. Single gases and binary and ternary mixtures of He, Ne, Ar, Kr, and Xe are applied, where the Xe concentration is varied from 0% to 100%. The performance is characterized in terms of the panel luminance, efficacy, and discharge voltages. It is found that while an increase in efficacy and luminance can be achieved in several multicomponent mixtures it is necessary to examine the associated increase in the firing voltage, Vf. If one considers the luminance versus Vf dependence, then binary NexXe1−x mixtures are optimal to achieve the highest efficacy values at the lowest Vf. The maximum efficacy gain factor in high Xe partial pressure mixtures is about a factor of 3 with respect to the mixture applied in default commercial panels.The influence of the noble gas mixture composition on the plasma display panel performance is investigated in test panels with a design which resembles the one used in commercial panels. Single gases and binary and ternary mixtures of He, Ne, Ar, Kr, and Xe are applied, where the Xe concentration is varied from 0% to 100%. The performance is characterized in terms of the panel luminance, efficacy, and discharge voltages. It is found that while an increase in efficacy and luminance can be achieved in several multicomponent mixtures it is necessary to examine the associated increase in the firing voltage, Vf. If one considers the luminance versus Vf dependence, then binary NexXe1−x mixtures are optimal to achieve the highest efficacy values at the lowest Vf. The maximum efficacy gain factor in high Xe partial pressure mixtures is about a factor of 3 with respect to the mixture applied in default commercial panels.


Daily the number of people looking for gyms to aid in the search for the desired aesthetic standard increases. With theincreasing demand for bodybuilding, the use of ergogenics has also increased, aiming to maintain health or even improve sportsperformance. The objective of the present study was to verify the incidence of ergogenic use and to characterize the bodybuildingindividuals who use ergogenic substances and to verify which professional is prescribing these substances. A total of 164bodybuilders were evaluated. The participants answered a questionnaire elaborated in Google Docs with the theme about theuse of ergogenic substances. The questions applied followed objective and multiple choice. Based on the data presented, it isconcluded that the use of steroids is not so common among bodybuilders, but their prescription does not happen due to the factthat in no case was there a medical prescription. With regard to supplements, its use is very common, for the various objectives,however, it is not frequent the indication made by a nutritionist. From the analysis of the data, it is noticed that there is even theintervention of Physical Education Professionals, which is not in accordance with the functions they must exercise, emphasizingthat each professional should act in the area in which he is responsible formation.


This article analyses the advantages and disadvantages of the innovation station construction.The station construction and the new modes of regional science and technology service are discussed;some countermeasures and suggestions are presented.


Author(s): Pena, William Antonio | Advisor(s): Fried, Daniel | Abstract: Dental caries is a widespread disease that affects many children. Through a concerted effort by the parents, dentist, and child, the decay process can be arrested/reversed by non-surgical means via fluoride therapy, antimicrobial rinses, dietary changes, or low-intensity laser irradiation. However, success of these preventative measures depends to a great extent on the early detection of the decay process. Traditionally, dentists have utilized tactile and visual techniques to detect caries, but unfortunately these methods have a low sensitivity. Conventional radiography (x-rays) is adequate for large, cavitated lesions; however, it does not have sufficient sensitivity for the detection of early, non-cavitated caries, root surface caries, or secondary caries. Moreover, due to the distinct morphology of the primary dentition, including thin enamel, proportionally thinner dentin, and large pulp chambers, the progression of caries is intensified. Therefore, new methods for early caries detection are necessary. Recently, new technology has been approved for the diagnosis of decay, e.g. the DIAGNOdent and QLF, but these devices detect caries in its late stages when surgical intervention is usually necessary. Moreover, these devices do not provide depth-resolved images of the caries and therefore, cannot be used to assess the effectiveness of properly implemented preventative measures. Polarization-sensitive optical coherence tomography (PS-OCT) is a non-invasive imaging technique which utilizes near-infrared (NIR) light to produce depth-resolved images of dental enamel and has the potential to monitor early enamel caries. The scattering of light in the sound enamel and dentin is sufficiently strong in the visible range to obscure light transmission through the tooth. However, in the near-IR at 1310nm, enamel is highly transparent. The tissue contrast with devices utilizing near-IR light arises from changes in tissue scattering as opposed to conventional radiography, which is based on variations in tissue density. Therefore, this method can be more sensitive than x-rays in detecting early caries lesions 25. The potential of NIR imaging of early caries lesions in primary teeth has not been investigated. These methods do not require exposure to ionizing radiation, deciduous teeth are smaller and more accessible, and the dentist can avoid the difficult procedure of placing x-ray films in uncooperative children. However, primary teeth differ in composition and structure from the permanent dentition and therefore, their optical properties are expected to be different. The overall objective of this research is to develop non-invasive optical devices for the detection and diagnosis of early dental caries in deciduous teeth. The objectives of this study will be achieved through the following specific aims:AIM # 1: To test the hypothesis that the scattering coefficient of sound deciduous enamel is orders of magnitude less at 1310 nm than in the visible range. AIM # 2: To test the hypothesis that trans-illumination with NIR can discriminate carious enamel from sound enamel with high contrast.AIM # 3: To test the hypothesis that PS-OCT can image and quantify occlusal caries lesions.


Objective: To examine the effects of autogenic training and abdominal breathing on heart rate and finger temperature. Methods: Forty-five healthy female university students were randomly assigned to three groups:control、autogenic training and deep abdominal breathing groups, and their physiological effects were compared. Results:The result of this experiment showed that both autogenic training and abdominal breathing increased finger temperature significantly, however, the increase magnitude didn't show significant differences in two groups.During autogenic training, the heart rate of autogenic training group declined significantly,the heart rate of deep abdominal breathing group decreased significantly after deep abdominal breathing. The decrease magnitude between the three groups showed no significant differences. Conclusion: Both the present techniques can decrease heart rate and increase finger temperature.


Immature dendritic cells (DC) reside in tissues where they initiate immune responses by taking up foreign antigens. Since DC have a limited tissue half‐life, the DC pool in tissues has to be replenished constantly. This implies that precursor/immature DC must be able to cross non‐activated endothelium using as yet unknown mechanisms. Here we show that immature, but not mature bone marrow‐derived murine DC migrate across resting endothelial monolayers in vitro. We find that endothelial intercellular adhesion molecule‐2 (ICAM‐2) is a major player in transendothelial migration (TEM) of immature DC, accounting for at least 41% of TEM. Surprisingly, the ICAM‐2‐mediated TEM was independent of β2‐integrins, the known ICAM‐2 ligands, since neither blocking of β2‐integrins with antibodies nor the use of CD18‐deficient DC affected the ICAM‐2‐specific TEM. In humans, the C‐type lectin DC‐specific ICAM‐3‐grabbing nonintegrin (DC‐SIGN) was shown to interact with ICAM‐2, suggesting a similar role in mice. However, we find that none of the murine DC‐SIGN homologues mDC‐SIGN, murine DC‐SIGN‐related molecule‐1 (mSIGN‐R1) and mSIGN‐R3 is expressed on the surface of bone marrow‐derived mouse DC. Taken together, this study shows that ICAM‐2 strongly supports transmigration of immature DC across resting endothelium by interacting with ligands that are distinct from β2‐integrins and DC‐SIGN homologues.


PurposeThe purpose of this study is to explore the impact of MFI-level governance on microfinance institutions' (MFIs') risk in Sub-Saharan Africa (SSA).Design/methodology/approachThe study uses data from a sample of 151 MFIs operating in 21 SSA countries during 2005–2014. The Feasible Generalized Least Squares (FGLS) regression model is applied to investigate the relationship between MFI level governance mechanisms and risk.FindingsThe study provides new evidence that board characteristics have differential effects on for-profit (FP) and not-for-profit (NFP) MFI risk. Board independence reduces credit risk of NFP MFIs. Foreign director presence increases MFI failure risk. Furthermore, greater female director representation reduces (increases) FP (NFP) financial risk whereas female CEOs are associated with higher (lower) FP (NFP) financial risk.Originality/valueThe paper contributes to existing literature on microfinance governance and risk, by exploring the impact of governance on MFI risk based on MFIs profit orientation. In addition, the study uses three different risk measures unlike previous microfinance studies.


The research of complex system science has became an very essential part of the system science. However,due to it's multi-level,nonlinear,and coupled with a large number of random uncertainties in the evolution of simulation work to the system caused immense difficulties.On this background,the real coded multi-objective nested accelerating genetic algorithm(RMONAGA) has been proposed to evolve and simulate the complex system.Based on the similarity between the features of system and characteristics of this algorithm,the problem of interaction of different levels and the adaptive conflict between different sectors has been solved by using the nested and multi-objective method.The method is applied to do the research of regional agricultural soil and water resources complex adaptive system optimization of Sanjiang Plain.The result shows that this method is scientifically rational,in order to provide some help in the field of modeling and simulation when CAS theory have been applied.


Introduction: Treatment of tuberculosis (TB) requires a combination of drugs. Isoniazid (INH) and pyrazinamide (PZA) are key components of the fi rst-line regimen used in the treatment of TB and monitoring these drug levels in plasma would help in better patient care. The objective of the study is to develop and validate a simple and rapid high performance liquid chromatographic method for simultaneous determination of INH and PZA in human plasma. Methodology: The method involved deproteinisation of plasma with para hydroxy benzaldehyde and trifl uoroacetic acid and analysis using a reversed-phase C8 column and UV detection at 267nm. The fl ow rate was set at 1.5 ml/min at ambient temperature. The accuracy, linearity, precision, specifi city, stability and recovery of the method were evaluated. The method was applied to estimate plasma INH and PZA collected from six children with TB. Results: Well resolved peaks of PZA and INH at retention times of 3.2 and 6.1 minutes respectively were obtained. The assay was linear from 0.25 - 10.0 ig/ml for INH and 1.25 – 50.0 ig/ml for PZA. The within-day and between-day relative standard deviation for standards were below 10%. The average recoveries of INH and PZA from plasma were 104 and 102% respectively. Conclusions: A rapid and accurate method for simultaneous determination of INH and PZA in plasma was validated. The assay spans the concentration range of clinical interest. The easy sample preparation and small sample size makes this assay highly suitable for pharmacokinetic studies of INH and PZA in TB patients. SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS 2012; IX (1) 13-18 DOI: http://dx.doi.org/10.3126/saarctb.v9i1.6960


Abstract Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain Tumours 1 (DMBT1) are three names for identical proteins encoded by the dmbt1 gene. DMBT1/SAG/gp-340 belongs to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins, a superfamily of secreted or membrane-bound proteins with SRCR domains that are highly conserved down to sponges, the most ancient metazoa. On the one hand, DMBT1 may represent an innate defence factor acting as a pattern recognition molecule. It interacts with a broad range of pathogens, including cariogenic streptococci and Helicobacter pylori, influenza viruses and HIV, but also with mucosal defence proteins, such as IgA, surfactant proteins and MUC5B. Stimulation of alveolar macrophage migration, suppression of neutrophil oxidative burst and activation of the complement cascade point further to an important role in the regulation of inflammatory responses. On the other hand, DMBT1 has been demonstrated to play a role in epithelial and stem cell differentiation. Inactivation of the gene coding for this protein may lead to disturbed differentiation, possibly resulting in tumour formation. These data strongly point to a role for DMBT1 as a molecule linking innate immune processes with regenerative processes.


Seed rice was treated with 0.25% methiocarb to test its effectiveness as a blackbird repellent in Vermilion Parish, Louisiana in the spring of 1975. Two replications of 3 treated and 3 untreated plots showed 68% more seedlings in treated plots (2,393) than in untreated plots (1,429). Half as many birds (chiefly redwing blackbirds, Agelaius phoeniceus, were recorded in treated (1.18/min) as in untreated plots (2.39/min).


Scholar-activism is an old practice with a relatively new name. Scholars have been actively working for social justice for decades. W.E.B. DuBois, for example, created some of the first American sociology studies while starting the NAACP and Pan-Africanist movements and permanently upending the Confederate version of Reconstruction. And, while not calling it "activism," academics on the Right have often worked to have their policies implemented. Milton Friedman's free market policymaking in Chile after the coup against the democratically elected socialist Salvador Allende is just one notable example. The Urban Affairs Association has developed initiatives to support scholar-activism. One of these is an award in honor of urbanist Marilyn Gittell. Another encouraged several gatherings of scholar activists, and some articles in this special issue resulted from those gatherings. The issues and methodologies used in these articles are varied. In one case, the employment of Black workers is increased on a huge publicly funded construction project. In another, neoliberal assumptions are turned upside down to reveal the brilliance of young people armed with a framework for analyzing their own life experiences. A third discusses an activist's use of social media and its relation to ethnographic studies. And others take up problems of planning and displacement.


Rayleigh scattering targets over clear oceans under large solar and viewing angles have proved their efficiency to calibrate remote sensing instruments in the blue channels. To obtain a good accuracy, this method needs an evaluation of the different contributors participant in the total TOA signal: aerosol, atmospheric conditions, foam, water reflectance. The near infrared is used to estimate the aerosol content which is after transfered in the band to be calibrated depending on the considered aerosol type. Atmospheric conditions and foam are evaluated with ECMWF data: water vapor content, surface pressure, wind speed. Two methods are described for the spectral transfer of the aerosol optical thickness and compared using different SPOT acquisitions: one using the absolute calibration coefficient and the other interband calibration coefficient. The absolute calibration coefficients are computed in the blue and green channels of SPOT3.


This article focuses on the Eastern Mediterranean pipeline project proposed by DEPA (Greece's public gas corporation), which is one option for the export of Eastern Mediterranean gas to Europe.


In this correspondence, we aim at achieving the energy-efficient secrecy transmission for an uplink network assisted by distributed intelligent reflecting surfaces (D-IRSs). The secrecy energy efficiency (SEE) maximization problem is investigated through jointly optimizing the discrete reflecting phase shifts, the transmit power, and the IRS switching status. To handle this non-convex problem, we decompose it into three subproblems, and then the majorization-minimization based algorithm, the Dinkelbach method and the Lagrangian dual method are adopted to obtain the solutions of reflecting phase shifts, transmit power and IRS switching status, respectively. The subproblems are alternatively optimized based on the iterative algorithm. Simulation results show that the proposed scheme can significantly improve the SEE compared to the centralized IRS, especially when the eavesdropping channel is stronger.


The over-the-wire double balloon technique (DBT) of balloon mitral valvuloplasty (BMV) has been decreasingly used in recent years because of its relative complexity and potential for left ventricular perforation. We attempted to make over-the-wire BMV simpler and safer by developing: (a) a single balloon technique (SBT) using a rapidly inflating, over-the-wire, cylindrical balloon having abrupt distal taper and short blunt tip to prevent left ventricular perforation, and (b) an alternative jugular approach to reduce technical difficulty in patients with cardiac anatomic distortion. SBT-BMV was evaluated over seven years in 1,407 consecutive patients (femoral approach: 1,277 patients, jugular approach: 130 patients), and compared with 954 patients who underwent DBT-BMV earlier at the same center. Results of SBT-BMV were comparable to those of DBT-BMV: optimal outcomes (91.0% versus 87.8%), fluoroscopy time (12.4 +/- 6.8 minutes versus 17.6 +/- 7.2 minutes), significant right heart oxygen step-up (4.8% versus 10.7%), and major complication rates (3.7% versus 5.6%) were significantly better with SBT-BMV; whereas mean post-BMV mitral valve area (1.92 +/- 0.31 cm2 versus 2.03 +/- 0.42 cm2), and post-BMV hemodynamic parameters were inferior with SBT-BMV. Balloon-related left ventricular perforation did not occur in SBT-BMV. Fluoroscopy time in jugular approach SBT-BMV (9.0 +/- 4.2 minutes) was significantly lower than in the femoral approach SBT-BMV (12.4 +/- 6.8 minutes) despite cardiac anatomic distortion. SBT-BMV reduced procedural costs considerably. SBT-BMV was effective, safe, technically simple and economical; it was comparable to, and overcame several limitations of DBT-BMV.


1. A mental hygiene program for the psychiatrically unfit soldier returning directly to civilian life has been described. 2. This program employs group psychotherapy combined with personal interviews to: (a) present an essentially physiological etiology of psychoneuroses in terms of situational reaction to a specific,i. e., military, environment; (b) deliberately arouse guilt by a discussion of evasion of duties and responsibilities and guide the emotional forces so generated along the lines of ventilation of hostilities and aggressive drives and compensating for guilt and inferiority by full participation in the war effort on return to civilian status. 3. The psychoneuroses, particularly the anxiety and psychosomatic states responded well to this approach. 4. The pre-psychotic, the psychopaths and the mentally deficient were largely unaffected. 5. The social and economic effects of persisting guilt and inferiority when exposed to critical and stigmatizing community attitudes were described as: (a) result...


Abstract Given an R -module V , the centralizer near-ring M R ( V ) is the collection of all functions ƒ: V → V such that ƒ( vr ) = ƒ( v ) r , for all v ∈ V , r ∈ R with the operations of point-wise addition and composition of functions, In this paper necessary and/or sufficient conditions are found for M R ( V ) to be a ring when R is a commutative local ring with nilpotent radical.


This thesis will address this problem and discuss preservation techniques through systemic analysis. The scope of the study from flowering to Korea after the war, which was built as a look at the construction period from the 1870s through the 1960s, will post. Utilized as exhibition facilities of modern buildings share examples of South Korea were included. Preservation of Modern Architecture in the way of research techniques, depending on the type of establishment at the time and compare the current situation, and accordingly the exhibition environment, by analyzing the future to take advantage of modern facilities in exhibit buildings, to provide basic data of this study intends to be mean. In conclusion, The exhibition facilities of modern buildings being used as a result of examining all 3 properties to the following conclusions were obtained. First, the spatial configuration of the facility at the head of exhibitions and linkages should be strengthened. Second, the exhibition environment is required for the expansion or renovation. Third, the modern buildings along the height of the building HVAC(Heating, Ventilation, Air conditioning) system is required.


In this paper studies on the lab formulated fritless silver thick film paste with two different binder compositions that have been used to fabricate λ/2 microstrip rejection filter in the X and Ku band are reported. These have been compared with ESL (USA) paste and copper thin film metallization for the same circuit. The thick film circuits were overlayed with TiO2 thick film of different thickness and changes in the characteristics studied. In the X band, the Q of the filter improves with overlay and is also dependent on the Ag paste formulation, whereas in the Ku band there are no thick film paste dependent properties observed due to overlay. Thickness of overlay and metallization paste formulation dependent factors should be taken into consideration during fabrication of high density and multi‐layer microwave integrated circuits.


Dissatisfaction with the group study approach to treatment efficacy for aphasia has led to widespread advocacy of single case studies. Such studies may also be important since they allow the individual clinician to evaluate her/his own therapy. Despite a wide literature on single case studies in general the details of their application in this area have received little discussion. It is argued that the approach is most compatible with the application of well defined treatment procedures to specific areas of linguistic deficit. Moreover the requirement for frequent assessments of progress is only likely to be met by the use of brief and equally specific assessment procedures designed by the therapist. Finally the likelihood that progress may be slow and may need to be dissociated from improvements due to natural recovery indicates the need for statistical analysis. Since the appropriate methods are little known some possible statistical procedures are discussed.


Background: This study was carried out to explore whether amnioscopy could help us to management of the uncertain date fetus to differ the prematurity from growth-restriction and assessment of post-term pregnancies as well. Notify the meconium staining of amniotic fluid is another aspect of amnioscopy, too. Study design: This was a descriptive study of 80 pregnant women from 2007 to 2008 at a university hospital, Tehran, Iran. The characteristics of amniotic fluid were documented on admission by inspection with transcervical amnioscopy, in all singleton pregnancies. Data were analyzed statistically. Results: Eighty women were admitted in labor during the study period and fulfilled the study inclusion criteria and had amniotic fluid evaluation available. Three pregnancies were uncertain date that managed according to amnioscope findings. Amniotic fluid were meconium stain in 22.5% (n = 18) and were clear 58.7% (n = 47) at amnioscopy and it was confirmed after delivery. Conclusion: This study suggests that amnioscopy is an easy and safe procedure for assessment of amniotic fluid characteristics. It could help us to differ prematurity (with vernix) from growth restriction(with yellowish or meconium staining) . Further analysis will determine its role in the perinatal outcome.


Materialization of High School Integrated to Professional and Technological Education: is it possible ?
In this text, I present a review of the book Oficina de Integracao: classroom experiences in Integrated High School, by Professor Dr. Adriano Larentes da Silva. The work presents the experience of more than 10 years of the integrated technical course in computer science, from the Federal Institute of Santa Catarina, Campus Chapeco, in the materialization of the Integrated High School (EMI) to the Professional and Technological Education (EPT), from the discipline Workshops of Integration. The EMI is a challenge for the subjects who work at EPT and who fight for an integral formation of the working class.
Keywords: Integrated High School. Integration Workshops. Integral Formation.


Abstract In winter 2002/03 and 2003/04, thermistors were installed in the ice on two shallow ponds in central Alaska, USA, in order to obtain data on ice temperatures and their response to increasing and decreasing air temperatures, and flooding and snow-ice formation. Snow depth and density, and ice thickness were also measured in order to understand how they affected and were affected by ice temperature variability. The lowest ice temperature (–15.5˚C) and steepest temperature gradient (–39.8˚Cm–1) occurred during a 9week period in autumn 2002/03 when there was no snow on the ice. With snow on the ice, temperature gradients were more typically in the range –20 to –5˚Cm–1. Average ice temperatures were lower during the warmer, first winter, and higher during the cooler, second winter because of differences in the depth and duration of the snow cover. Isothermal ice near the freezing point resulted from flooding and snow-ice formation, and brief episodes of warm weather with freezing rain. Under these circumstances, congelation-ice growth at the bottom of the ice cover was interrupted, even reversed. It is suggested that the patterns in temperatures brought about by the snow-ice formation and rain events may become more prevalent due to the increase in frequency of these events in central Alaska if temperature and precipitation change as predicted by Arctic climate models.


Objective: A simple and sensitive spectrophotometric method has been proposed for quantification of Gliclazide in pure and dosage form.
Methods: A visible spectrophotometric methods based on the ion-pair formation of drug with the dye Cresol Red (Method A) and Bromophenol Blue (Method B) in methanol medium.
Results: A purple colour complex was formed in Method A while orange colour was obtained by Method B with maximum absorption at 510 nm and 445 nm, respectively. The Beers law was found linear over the concentration range from 30 to 200µg/ml (Method A) and from 70 to 230µg/ml (Method B) with good correlation coefficients 0.9918 and 0.9916 respectively. The molar extinction coefficient were 0.1326 x 104 L/mol/cm (Method A) and 0.1294 x 104L/mol/cm (Method B), LOD 0.2563, 0.4681 and LOQ 0.6394µg/ml and 0.9256 µg/ml.
Conclusion: The proposed methods were statistically evaluated for accuracy, precision and linearity in terms of standard deviation, percentage recovery, percentage error and relative standard deviation. The proposed methods can be applied in routine analytical and quality control laboratories for the quantification of Gliclazide. The methods are simple, sensitive, rapid and economical for the estimation of Gliclazide in pure and dosage forms.


First, second and third nearest neighbor pair mixing potentials for equiatomic FePt alloys were calculated from first principles by the Connolly-Williams method within the canonical cluster expansion formalism. Using the mixing potentials obtained in this manner, the dependency of equilibrium L1_0 ordering on temperature was studied for bulk and for (approximately) spherical nanoparticles ranging in size from 2.5 to 6nm. The order parameter was calculated using Monte Carlo simulation and the analytical ring approximation. For nanoparticles of finite size, the (long range) order parameter changed continuously from unity to zero with increasing temperature. Rather than a discontinuity indicative of a phase transition, we obtained an inflection point in the order as a function of temperature. This inflection point occurred at a temperature below the bulk phase transition temperature and decreased as the particle size decreased. Our calculations predict that 3.5nm diameter particles in configurational equilibrium at 600 C (a typical annealing temperature for promoting L1_0 ordering) have an L1_0 order parameter of approximately 0.84 (compared to a maximum possible value equal to unity). According to our investigations, the experimental absence of (relatively) high L1_0 order in 3.5nm diameter nanoparticles annealed at 600 C or below is primarily a problem of kinetics rather than equilibrium


With the aid of square-wave-voltammetry, redox equilibria of various multivalent elements were studied in a soda-lime-silicate and a borosilicate glass melt in the temperature range of 600 to 1300°C. The peaks in the current-potential curves could be attributed to certain redox couples. The peak potentials measured dependend linearly on temperature proving that both standard enthalpy and standard entropy possess constant values within the temperature range studied. The peak potentials measured in the silicate and the borosilicate melt were in fairly good agreement. A systematic shift caused by the higher alkali content of the borosilicate glass could not be observed.


BACKGROUND
A Canadian Agency for Drugs and Technologies in Health (CADTH) therapeutic review concluded that bevacizumab and ranibizumab have similar efficacy and safety in treating retinal conditions and recommended bevacizumab be used as preferred initial therapy based on a cost-saving perspective. Such use would be off-label because bevacizumab is not approved for these conditions and has a serious safety warning (SSW) in its Product Monograph (PM) about intravitreal use.

OBJECTIVE
To evaluate whether the Ontario Public Drug Programs (OPDP) reimbursement is provided only for off-label use for serious, life-threatening or severely debilitating conditions and not when the drug's PM contains a SSW against such use.

METHODS
OPDP reimbursement criteria for non-palliative drugs from its frequently-requested Exceptional Access Program (EAP) and Limited Use (LU) lists were compared with approved indications and SSWs in the drugs' PMs.

RESULTS
Of 125 unique frequently-requested non-palliative EAP drugs, 12 included off-label use for serious conditions for which no alternative treatment exists. Eight of the 12 had SSWs, but only one warning for orally-administered sirolimus related directly to the OPDP-reimbursed off-label use. Of 29 injectable non-palliative LU drugs, one had off-label LU criteria allowing reimbursement for an unapproved indication and a SSW unrelated to the reimbursable indication.

CONCLUSION
Presently, OPDP only reimburse drugs for off-label use for the treatment of serious, life-threatening or severely debilitating conditions for which no alternative treatment exists. OPDP should not diverge from this approach by allowing cost-savings to trump appropriate drug use, which would set a unique and unprecedented example.


The problem of non payment of maintenance orders has been widely recognized in many jurisdictions. It has attracted a considerable body of applied research and programm development. After reviewing, with statistical data, the ineffectiviness of Court enforcement procedures, the author analyzes the reasons for non enforcement and the remedies which have been adopted in the Province of Quebec. The author distinguishes between what she calls preventive remedies, collecting and penalties. Lastly, she concludes that the problem goes far beyond the law and that a re-thinking of the issues involved, particularly at the economic level, remains a necessity.


The primary aim of this study was to identify the ease and safety of office‐based lower airway endoscopy (OLAE) in patients with and without comorbidities. In addition, we identified the most common indications for OLAE and the associated diagnosis.


Legislation, court decisions, and the changing political and social climate provide evidence of the importance of the outcomes of EEO litigation involving challenged selection procedures for transfer, training and development, and promotion. These selection procedures are being challenged by more informed employees and, in many cases, result in costly litigation. Thus, organizations must be aware of the continuing developments in employment law especially as found in court decisions and related legislation. This study investigates judicial and EEOC decisions in discrimination cases to provide answers to these questions: Are organizations aware of the outcomes of EEO litigation involving challenged selection procedures for transfer, training and development, and promotion? Are organizations aware of what constitutes a discriminatory practice in the selection of employees for transfer, training and development, and promotion? Does management recognize and follow nondiscriminatory procedures in selecting personnel for transfer, training and development, and promotion? The purposes of the study are 1. To analyze outcomes of EEO litigation involving challenged selection procedures for transfer, training and development, and promotion; 2. To develop a model set of guidelines to aid organizations in developing nondiscriminatory procedures for use in selecting employees for transfer, training and development, and promotion. This study concludes that many employers are aware of the outcomes of EEO litigation involving challenged selection procedures for transfer, training and development, and promotion. Many employers are also aware of what constitutes a discriminatory practice in the selection of employees for some employment advantage. However, management does not always recognize and follow nondiscriminatory procedures when selecting employees for transfer, training and development, and promotion. The number of cases in which selection procedures were found discriminatory supports this conclusion.


Purpose – This paper aims to highlight two recent copyright controversies that have implications for academic institutions in the USA.Design/methodology/approach – The paper focuses on the copyright infringement case against Georgia State University, detailing aspects of the lawsuit as they are noted in the complaint.Findings – The paper recognizes the well‐documented case against Georgia State University is strong, especially given contemporary views on fair use.Originality/value – This paper offers depth to important copyright stories that may affect US institutions.


Over the past decade, Multibeam Echosounders (MBES) have become one of the most used techniques in sea exploration. Modern MBES are capable of acquiring both bathymetric information on the seafloor and the reflectivity of the seafloor and water column. Water column imaging MBES surveys acquire significant amounts of data with rates that can exceed several GB/h depending on the ping rate. These large file sizes obtained from recording the full water column backscatter make remote transmission difficult if not prohibitive with current technology and bandwidth limitations. In this paper, we propose an algorithm to decorrelate water column and bathymetry data, focusing on the KMALL format released by Kongsberg Maritime in 2019. The pre-processing stage is integrated into FAPEC, a data compressor originally designed for space missions. Here, we test the algorithm with three different datasets: two of them provided by Kongsberg Maritime and one dataset from the Gulf of Mexico provided by Fugro USA Marine. We show that FAPEC achieves good compression ratios at high speeds using the pre-processing stage proposed in this paper. We also show the advantages of FAPEC over other lossless compressors as well as the quality of the reconstructed water column image after lossy compression at different levels. Lastly, we test the performance of the pre-processing stage, without the constraint of an entropy encoder, by means of the histograms of the original samples and the prediction errors.


'The emerging time of occupying illegally as object' has been attracting more and more attention in the field of criminal law,especially important in distinguishing different crimes,being guilty or guiltless in the crime of swindling in contract.'The emerging time of occupying illegally as object' in the crime of swindling in contract only exists before the owner's disposing of the property,and there is no afterwards intention in the crime of swindling in contract.


In an effort to identify novel drugs targeting fusion-oncogene induced acute myeloid leukemia (AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE) driven AML we uncovered a de-regulation of phospholipase C (PLC) signaling. We identified PLCgamma 1 (PLCG1) as a specific target of the AE fusion protein which is induced after AE binding to intergenic regulatory DNA elements. Genetic inactivation of PLCG1 in murine and human AML inhibited AML1-ETO dependent self-renewal programs, leukemic proliferation, and leukemia maintenance in vivo. In contrast, PLCG1 was dispensable for normal hematopoietic stem- and progenitor cell function. These findings are extended to and confirmed by pharmacologic perturbation of Ca++-signaling in AML1-ETO AML cells, indicating that the PLCG1 pathway poses an important therapeutic target for AML1-ETO positive leukemic stem cells.


Automatic Chinese word segmentation is the basis of Chinese information processing.It is expensive for obtaining parameter to use lage-scale annotated corpus.This paper presents a new statistical measure mt,in terms of a linear and non-linear combination of two common statistical measures,mutual information and difference of t-test.All statistical data needed derived from raw corpus automatically without using lage-scale annotated corpus,which aim to decrease cost.The experimental result shows segmentation accuracy reachs 80.14%.The segmentation is better compared to using mutual information and difference of t-test singly.


In the changing business environment, customers' service experience has become a new dominant logic that drives the service businesses, and inspires service providers to design, offer, evaluate and measure memorable service experience. Offering products or services alone is no longer enough, organisations must provide their customers with satisfactory service experiences, by orchestrating all the clues that customers detect in the service consumption and engage customers to sense, feel, think, act and relate to organisations service package and brand. This paper presents in-depth review of literature on offering service as experience. It focuses on service contexts, research focus, constructs and realms of service experience explored, main research issues raised. This study proposes a set of propositions that relates service encounter, employees' service behaviour, servicescapes, service delivery and customer service experience.


AssrRAcr The crystal structures of 13 alkali amphiboles have been refined to R values of l-2o/o using single-crystal MoKa X-ray data. Crystals used in the collection of the intensity data were subsequently analyzed by electron and ion microprobe. Site occupancies were assigned by site-scattering refinement and stereochemical considerations, taking into account the electron and ion microprobe analysis of each crystal. These alkali amphiboles are primarily eckermannite-arfvedsonite from peralkaline granites. Their X-ray scattering behavior is very different from most other monoclinic amphiboles; they show anomalously low scattering at the M3 site relative to that observed at the Ml and M2 sites. Ion microprobe analysis confirmed the presence of significant amounts of Li, up to 0.61 apfu (- 1.0 wto/o LirO), that the scattering results show to be completely ordered at the M3 site. These amphiboles contain significant amounts of Mn, up to 0.92 apfu (-6.9 wto/o MnO), and minor Zn; the Mn is dominantly divalent and is distributed over the Ml, M2, and M3 sites. Fe3*/Fe2+ ratios were assigned on the basis of mean bond length considerations. Li enters the arfvedsonite structure primarily by means of the substitution tM3ll-i * Fe3+ + tM3lFe2+ * p"z*[LiFer+ (Fer+) ,] giving rise to the ideal end-member NaNarFel*LiFel+SisC)rr(OH)r. The dominant compositional variation among the alkali amphiboles examined here is from manganoan arfvedsonite toward this Li-bearing end-member; an additional minor nyboitic substitution occurs but decreases with increasing Li content. Examination of the analytical data for these amphiboles, together with various formula renormalization procedures, shows that apparent anomalies in alkali amphibole stoichiometry (Si contents > 8 apfu; low C-group cation sums; A-site sums exceeding I apfu) are due to incomplete chemical analyses (specifically, no determination of Li and HrO) and incorrect assumptions in the renormalization procedures (e.g., OH + F : 2.0 apfu). In addition, the anomalously high Fe3*/Fe2+ ratios reported in previous wet-chemical studies are probably the result of (unrecognized) incorporation of Li into the structure by the substitution proposed above. By using the standard compositional criteria, the identification of only two distinct compositional trends in alkali amphiboles from silica-saturated peralkaline igneous rocks (magmatic-subsolidus and oxidizing, with the inference that the magmatic-subsolidus trend must be reducing) is invalid. The amphiboles examined here are classified as magmatic subsolidus by the usual criteria but have as high or higher ratios of Fe3+/(Fe2+ + Fe3*) than the riebeckitic compositions designated as oxidized, the high Fe3+ contents occurring in the structure in concert with increasing Li content. It is essential that Fe3+/Fe'z+ ratios be measured if amphibole compositions are to be used to derive information on redox conditions of crystallization.


This paper addresses 3D laser imaging. 3D active imaging or 3D laser imaging has been greatly improved with the development of highly sensitive, high pixel density cameras. In this paper, we develop a 3D laser imaging method using tomographic algorithm. We obtain the three-dimensional reconstruction by a cone-beam algorithm (1), which is a convolution back- projection algorithm deduced from the Radon transform. This algorithm uses a set of two- dimensional projections which contain the data collected by the pixels of a focal plane area. These data are related to the intensity backscattered by the scene illuminated by a laser pulse. The scattered intensity contains the information for the 3D reconstruction. This process allows the reconstruction of a 3D scene from a series of images parameterized by an angle of axial rotation. In this paper, we study the robustness of this algorithm. To analyze the 3D reconstruction algorithm, we give experimental proof of the theory. We develop a 3D imaging experiment based upon a two-dimensional imaging device with high pixel density in the visible band. 1. INTRODUCTION In this paper, we present 3D laser imaging experimental data. There is a considerable interest in the development of new optical imaging systems that are able to give three-dimensional images. Potential applications range across the fleld of defense and security for the recognition of targets, the medical fleld for the detection of subcutaneous and cutaneous tumors or the fleld of micro- electronics for the observation of hardware components during their manufacture. Identifying targets or objects concealed by foliage or camou∞age is a critical requirement for operations in public safety, law enforcement and defense. The most promising techniques for these tasks are 3D laser imaging techniques. Active imaging systems use a near-infrared or visible laser and a suitable detector. We propose a tomographic method to enable a super-resolution 3D reconstruction from several intensity images of hidden objects. The laser illuminates the scene and the re∞ected radiation is collected by a detector to give a two-dimensional image. We obtain a three-dimensional image through a tomographic algorithm taking into account 2D images with difierent angles of view. 2. THREE-DIMENSIONAL REFLECTIVE TOMOGRAPHIC RECONSTRUCTION An optronic system creates a 3D image of an object present in a complex optronic scene. This image must for example make it possible to pick out camou∞aged targets behind camou∞age netting, under trees, etc. This operational condition constitutes the major problem. Our technique is based upon a 3D tomographic reconstruction (2,3). In this fleld of 3D imaging, it is necessary to obtain a set of measured data of the considered object to be reconstructed dependent on a variable parameter (angle of view). This data set makes it possible to reconstruct the volume by applying inverse reconstruction techniques. From a mathematical point of view, the technique breaks down into two steps: direct measurement, optionally processed using a model of the physical phenomena which are measured or in our case measured data, and then reconstruction by inversion on the basis of these direct measures. The flrst problem consists in providing in a reasonable time a set of direct data that can be utilized for the inversion process. This problem naturally covers all the technological di-culties (high rate illumination laser, short pulse, detector block, pointing...). The second problem relates to the inversion procedure used and its mathematical implementation. For the inversion method, we use a cone-beam algorithm, which is a convolution back-projection algorithm deduced from the Radon transform. In classical tomography, a thin beam (X-ray, laser ...) propagates through the studied volume and reaches the detector which collects the data given by the transmitted electromagnetic waves. The obtained projection represents the attenuation by the penetrated volume along a straight line of the ray. As shown in Fig. 1, the projection data Pµ obtained for a given angle of observation µ is the line integral of the 2D-object f(x;y) in the (t;s) axis.


High power amplification of an electro-optic frequency comb to 200W is achieved, featuring sub 500 fs pulses over a widely tunable repetition rate in the 1-18 GHz range. The final amplification stage of the monolithic set-up includes a full-silica large-mode-area microstructured polarization-maintaining ytterbium-doped fiber with a mode field diameter of 24 µm and M2 -parameter values below 1.1. Pulse durations as low as 192 fs were recorded from output pickoff compression.


comments. The views expressed are the authors' and do not necessarily reflect the views of the Federal Reserve Bank of Chicago or the Federal Reserve System.


In the Chinese history,it is very prevalent that the businessman invested to land greatly.This paper exerts the method of New Institutional Economics to explore the causes of this phenomenon.We argue that it is the influence of feudal society's formal institutions and the informal institutions that advanced the business capital to transform to land capital.But this transformation of business capital is bad for the development and progress of Chinese society.


help guide further investigation in this area. the search for ways to prevent this disruptive side effect. The current studies provide mechanistic insights that should Additional work will be necessary to further expand our understanding of EGFR inhibitor toxicity and to continue skin macrophages may contribute to the adverse effects of EGFR inhibitors. studies suggest that EGFR signaling is important for normal skin barrier function and antimicrobial defense and that and immune cell types to determine which ones are necessary for the rash phenotype. The findings of these two investigated the effects of crossing mice that lack EGFR in the skin with mice deficient in different immune pathways patients and study animals and examined the effects of EGFR inhibition on skin defenses and bacteria. They also patients treated with EGFR inhibitors. They characterized the changes in chemokine expression in the skin of treated Both sets of authors used mouse models that lack EGFR only in the skin to replicate the pattern of injury seen in this phenomenon. to mechanism of rash formation induced by EGFR inhibitors and uncover some of the skin components that contribute . help clarify the et al . and Lichtenberger et al prematurely stop their treatments. Now, two papers by Mascia inhibitors are particularly known for causing a severe rash and skin damage, which sometimes forces patients to correlates with its side effects, as is the case for inhibitors of the epidermal growth factor receptor (EGFR). EGFR body. This can be difficult to achieve for cancer drugs, however, especially when the effectiveness of a drug directly The goal of all medical interventions is to treat disease while minimizing the damage to healthy tissues in the Skin-Deep Search for the Effects of EGFR Inhibitors


A 35-year-old woman presented to our dermatology department with itchy erythema after using metronidazole intravaginal ovules. She had received the ovules from a gynaecology clinic for treatment of heavy vaginal discharge. Despite the onset of buttock-associated itchiness, she continued ovule treatment; however, itchiness expanded to the back and abdomen. The patient visited our hospital's emergency department and received 125 mg intravenous methylprednisolone; she was then referred to our dermatology department. Examination revealed mainly genital-associated erythema (Figure 1A). The thigh and lower leg exhibited welldemarcated erythema and small vesicles (Figure 1B,C). We thus prescribed 30 mg oral prednisolone for a five days, followed by dose tapering. Six weeks later, a patch test on the upper arm (where no


In this paper, we present a one parameter family of fully discrete Weighted Sequential Splitting (WSS)-finite difference time-domain (FDTD) methods for Maxwell's equations in three dimensions. In one time step, the Maxwell WSS-FDTD schemes consist of two substages each involving the solution of several 1D discrete Maxwell systems. At the end of a time step we take a weighted average of solutions of the substages with a weight parameter θ, 0 ≤ θ ≤ 1. Similar to the Yee-FDTD method, the Maxwell WSS-FDTD schemes stagger the electric and magnetic fields in space in the discrete mesh. However, the Crank-Nicolson method is used for the time discretization of all 1D Maxwell systems in our splitting schemes. We prove that for all values of θ, the Maxwell WSS-FDTD schemes are unconditionally stable, and the order of accuracy is of first order in time when θ 6= 0.5, and of second order when θ = 0.5. The Maxwell WSS-FDTD schemes are of second order accuracy in space for all values of θ. We prove the convergence of the Maxwell WSS-FDTD methods for all values of the weight parameter θ and provide error estimates. We also analyze the discrete divergence of solutions to the Maxwell WSS-FDTD schemes for all values of θ and prove that for θ 6= 0.5 the discrete divergence of electric and magnetic field solutions is approximated to first order, while for θ = 0.5 we obtain a third order approximation to the exact divergence. Numerical experiments and examples are given that illustrate our theoretical results.


This paper presents a current market analysis for short-term flexibility options realized by electricity generation and load devices. An assessment of appropriate flexibilities is given by evaluating the technical potential under consideration of constraints. For these flexibilities two distribution channels are discussed by showing the historic capacity fees and energy prices for minute reserve and the remuneration for interruptible load. Furthermore the revenue potential for different heating technologies in residential buildings is evaluated in detail. This evaluation considers the availability of the devices based on individual load profiles and the prices on the minute reserve market per time slice in dependence of the activation. The results show that the revenues vary strongly by year and heating technology.


According to the problem of rock burst and the development of acoustic emission technology,this paper summarized the characteristic parameters of acoustic emission and rock,and used the multiple neural networks classifier which is composed by the simple BP-network to synthesize the parameters in(order) to predict rock burst.


The article considers the nature, functions, structural units of hypertext, its advantages in social communication. The features of the use of hypertext technology in training, set out the principles of creating hypertext in preparing educational multimedia resources, requirements for them.


Fluorescent spectroscopy is an important method in life science which has recently gained popularity. Fluorescent spectroscopy is widely used for example by the researches in the variety of biological structures, intercellular interactions, various kinds of biomolecules and also for understanding of the biochemical processes which take place inside the living organisms. For this purpose, an application of fluorescent sensors and searching for more efficient and more sensitive fluorophore for illustrating, labelling and detection, have become a developing trend in biochemistry, medicine, biology and also in many other chemistry researches. Nowadays, issues which are connected to fluorescence are mainly applied to the newest achievements in the field of fluorescent methods and measurement techniques and also to the development and applications of fluorescent probes, what is closely showed up in this article.


Anomalies in the far-infrared [C II] 158 line emission observed in the central one-kiloparsec regions of spiral galaxies are reviewed. Low far-infrared intensity ratios of the [C II] line to the continuum were observed in the center of the Milky Way, because the heating ratio of the gas to the dust is reduced by the soft interstellar radiation field due to late-type stars in the Galactic bulge. In contrast, such low line-to-continuum ratios were not obtained in the center of the nearby spiral M31, in spite of its bright bulge. A comparison with numerical simulations showed that a typical column density of the neutral interstellar medium between illuminating sources at is in the region; the medium is translucent for photons sufficiently energetic to heat the grains but not sufficiently energetic to heat the gas. This interpretation is consistent with the combination of the extremely high [C Il]/CO J