While much critical attention has been paid to white audiences' use of images of "the Indian" in the nineteenth and early twentieth centuries, less is known about how indigenous people at the time may have understood or used these images. This essay examines the photographs of local historian John Henry Hauberg to track the uses of portraits of the Sauk leader Black Hawk and his descendants as they were interpreted by both white audiences and by members of the Sauk nation in the early twentieth century. While Hauberg encouraged white audiences to identify with the patriotism and masculinity of Black Hawk, displaced members of the Sauk nation negotiated the symbolic system represented by photography—its claim to authenticity, its power to organize experience, its function as a tool of remembrance—to generate meanings and histories more compatible with their own experiences.


Integration of bovine leukemia proviral DNA in the genome of infected cells was investigated in cattle affected by either the persistent lymphocytosis or the lymph node tumor form of enzootic bovine leukosis. In persistent lymphocytosis, proviral DNA was found to be integrated at a large number of genomic sites in one-fourth to one-third of circulating leukocytes. In the lymph node tumor form, in contrast, proviral DNA was found to be integrated at one or very few sites in the genomes of a larger fraction of both circulating leukocytes and lymph node tumor cells. Enzootic bovine leukosis (EBL) is a lymphoproliferative disease of cattle induced by an exogenous retrovirus, the bovine leukemia virus (BLV) (1-3), whose target cell is the B lymphocyte (4). Two forms of the disease are known: persistent lymphocytosis (PL), characterized by a permanent large number of peripheral lymphocytes (5-7), and a tumoral form, characterized by lymph node tumors. These two forms generally represent the early and the late stage of the disease, respectively. In some cases, however, these two pathological conditions do not affect the same cattle herds, suggesting that they may represent separate responses to BLV infection, both of them being under the control of genetic factors (8-10). In general, the fate of BLV-infected animals is variable and depends upon several factors, including age, genetic make-up, environmental factors, and immunological surveillance (see ref. 11 for a review). In the present work, we have compared proviral integration into the genomes of host cells of naturally infected animals that were in either the PL or the tumor stage of the disease. The main result obtained in these investigations was that proviral copies were found to be integrated at several sites in the genomes of one-fourth to one-third of the leukocytes of animals in PL, but at only one or very few sites in the genomes of a larger fraction of leukocytes or tumor cells of animals in the tumor stage of the disease. MATERIALS AND METHODS Bovine tissues and cells were collected from seven animals with EBL. Four animals (nos. 928, 641, 2586, and 4) were in PL and three (nos. 15, 950, and 82) in the tumor stage of the disease. Leukocytes (W928, W641, W2586, W4, W15, W950, and W82), lymph node tumors (T15 and T950), and the thymus of a normal calf were used as sources of DNA. Preparation of virus and viral DNA, cDNA synthesis, DNA The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact. 2577 extraction, digestion with restriction endonucleases, and gel electrophoresis were done as described (12, 13). Gel transfer and filter hybridization were carried out as described (13, 14), except that BLV [32P]cDNA was prehybridized for 16 hr with 3 mg of sonicated, denatured calf thymus DNA per ml; this largely prevented spurious hybridization of the probe with satellite and ribosomal DNA (13). Filters were exposed at -70°C to preflashed Kodak RP-Royal X-Omat film in the presence of Siemens "special" intensifying screens for 2-5 days. Liquid hybridization was performed as described (2).


The teaching quality of the drug laws and regulations will be improved by analyzing the barriers in the course of studying the drug laws and regulations and taking the teaching strategies for secondary vocational students.


The spent fuel disposal is a very important step during the recycling of nuclear fuel and the operation process is very complex and dangerous. With the fast development of nuclear power reactor in china, more and more spent fuel will occur and should be treated in the near future. For researching the spent fuel management and training the operators, we have been developing the virtual reality (VR) Simulation System for spent fuel reprocessing (VRSS) aimed at demonstrating and analyzing the treatment process. The VRSS is based the VR and visualization technology. Combined with the regulation of radiation protection, the integrated virtual operate environment is developed to enable user navigation the working place, and obtain target information "it can demonstrate the structure and component of equipment, it also can illustrate the disassembly craft transform principle and the operation way of extraction facility. It even can prompt the user how to operate when spent fuel handling accident occur.Copyright © 2008 by ASME


A screening-level evaluation of potential remediation methods for application to the contaminants of concern (COC) in the 200-BP-5 Operable Unit at the Hanford Site was conducted based on the methods outlined in the Guidance for Conducting Remedial Investigations and Feasibility Studies under CERCLA Interim Final (EPA 1988). The scope of this screening was to identify the most promising remediation methods for use in the more detailed analysis of remediation alternatives that will be conducted as part of the full feasibility study. The screening evaluation was conducted for the primary COC (potential major risk drivers) identified in the groundwater sampling and analysis plan for the operable unit (DOE/RL-2001-49, Rev. 1) with additions.


The G8 (Group of Eight) – an informal group composed of the leaders of, traditionally and not contemporaneously, the world's most industrialized states (Canada, France, Germany, Italy, Japan, Russia, the United Kingdom (UK) and the United States (US)) – summit at the 2005 Gleneagles in the UK saw members of the G8 agreeing to a number of ambitious commitments, or pledges, vis-à-vis aid and trade, as outlined in the appendix, with the aim of (a) facilitating development and (b) eradicating poverty in Africa (Holman et al, 2005) – understood as sub-Saharan Africa in general. It was the culmination of the then British Prime Minister Tony Blair's 'Year of Africa' (Holman et al, 2005). The news of the G8's undertaking of specific measures designed to ignite, or at least facilitate, the development of Africa was greeted by much fanfare, with both Bono and Bob Geldof praising the leaders of the G8 member states, leaving Kumi Naidoo of the Global Campaign Against Poverty as the solitary voice of criticism (Holman et al, 2005). Some (Holman et al, 2005) believed that the G8 Gleneagles summit would mark a turning point in Africa's fortunes and would see Africa finally achieve the developmental success that first Japan, then the East Asian Tigers, and now China have experienced and still are experiencing.


This article analyses the critical thinking of previous studies from various perspectives on the stereotypes of Chinese students. It focuses on three aspects: What are the earlier stereotypes of Chinese students from numerous international scholars? What do they regard as the reasons for these stereotypes, and what are their respective attitudes? What are the new in-depth views of scholars on these stereotypes, and what initiatives have been proposed to improve the stereotypes of Chinese students? These questions are answered in the following main body section. Through the analysis and summary of scholars findings, it is found that stereotypes of Chinese students can be mainly related to learning styles and traditional Chinese cultural characteristics. The cause of stereotypes primarily comes from the influence of cultural differences between China and the West and the lack of understanding of Chinese education. The scholars critical views on Chinese students stereotypes are mainly about the internal and external environmental influences on Chinese students and the consequences of stereotypes. Therefore, this paper contributes to future research on improving Chinese students stereotypes in the context of international education.


Importance of intensifying pre-desilication under existing production conditions of Zhongzhou Aluminum Plant is stressed. Extensive study is conducted for the factors effecting the pre-desilication process. The results shown that the silica module of the desilicated liquor under proper technical conditions can be up to more than 150 compared with a silica module of only 50-70 under the original production conditions. Based on the experimental results, technical reformation has been performed, creating a favorable condition for the running of indirect heating high-pressure desilicating units and extending of their running cycle.


Soundness and longevity of the riding horse play a central role for animal welfare, sport performance and horse owner economy. Routine registration of health traits in horses is rare. Thus, knowledge of genetic variation in health of horses and long term effects on longevity is scarce. The major aims of this thesis were to estimate prevalence and heritability of orthopaedic health findings, and genetic and phenotypic relationships between orthopaedic health, conformation and longevity in the Swedish warmblood horse. The included studies I-IV were based on standardised documentation of health and conformation at the Riding Horse Quality Test (RHQT) of 8238 tested 4-5-year-old horses, participating during 1983-2005. Longevity was measured as number of years in competition (NYC), and lifetime performance results from official competitions (LPERF) during 1983-2012. Results show that conformation significantly influences health status of the horse, and that both health and conformation of the young horse influence future longevity and success in competition, both phenotypically and genetically. Longevity was generally better in horses with good young horse health regarding palpatory orthopaedic health, locomotion, hooves and assessed overall orthopaedic health. Effusions were the most common clinical health finding, whereas severe acute findings were relatively rare. Horses with flexion test reactions had significantly lower chances of competing later in life compared to horses without reactions. Regarding conformation, intermediate sized horses with high scores for type and head-neck-body conformation, light front and correct movements in trot at hand were found most important. Also, the assessed talent of a young horse was influenced by the health and conformation, both for dressage and jumping. Good health was genetically correlated with better longevity at a level of 0.3, with similar correlations between high conformation scores and longevity. Heritabilities of palpatory orthopaedic health and hooves were estimated at 0.10-0.14, and between 0.20-0.36 for overall conformation traits, except for limbs at 0.06. Considerable genetic variation of conformation and to some extent of health, and generally favourable associations between health, conformation, longevity and performance, suggest possibilities to improve health traits if considered in breeding.


The use of combat drones has been existing for more than a century. Only in recent years have we witnessed how the evolutionary process with the advancement of technology has turned into a real revolution. The conflict in Nagorno-Karabakh in 2020 was one of the turning points in the application of this ditruptive technology for combat purposes. As never before, the mass use of combat drones has not decisively influenced the outcome of a conflict. Due to the importance of the mentioned conflict, an SWOT analysis of the possibility of using combat drones in local conflicts was performed. The conclusions drawn can help both in understanding the outcome of the conflict and in defining the direction in which the further application of these combat systems will progress in the future.


During the 2011 off the Pacific Coast of Tohoku earthquake, most super high-rise RC buildings constructed in the metropolitan area had suffered severe shaking, leading to variation of dynamic properties due to structural damages. This study describes the damage estimation of the super high-rise RC building during the main shock using the 3D frame model. Their varying dynamic characteristics are discussed based on the system identification method. The dynamic properties during aftershocks are also investigated in view of the residual seismic performance after experiencing moderate-level structural damages.


The pediatric population in Malaysia has seen a rapid surge in the prevalence of early childhood caries (ECC). Based on surveys, the major predisposing factor for ECC among children in Malaysia seems to be the practice of long-term breastfeeding (up to 2 years) followed by prolonged bottle feeding which exceeds the time frame recommended by the American Academy of Pediatrics (up to 15 months).[1-3] In most of these cases, all the decayed primary teeth are extracted either under general anesthesia in a single setting or as an outpatient procedure involving several visits.[1] The extreme treatment strategy in such cases is because most ECC cases reach a pedodontist at a relatively advanced stage by which time extraction is the only effective treatment strategy. The delay in diagnosis and treatment can be attributed to the current dental health-care system. As dental treatment is a relatively costly affair,[4] most patients register for treatment in government facilities, for which the waiting period lasts for several months. Thus, at the time of examination, most children present with grossly decayed teeth. The overall sequence of rapid caries and multiple extractions results in a partial to complete edentulous state in children which often leads to several psychological problems including developing an inferiority complex.[5] Lack of teeth also discourages the children from a healthy food intake which, in turn, can lead to malnourishment. In addition, there is increased risk of the infection being transmitted from the primary teeth to the developing permanent tooth buds. To overcome these issues, it is important to educate the parents about the effects of long-term breast and bottle feeding. It is essential that appropriate prophylactic measures are employed to prevent the onset and spread of ECC. The government should take measures to reduce the waiting period for dental treatment in government hospitals. To conclude, preventive measures (reducing the bottle-feeding time), early diagnosis (reducing the waiting time in government hospitals), and early conservative treatment approach (protecting the primary teeth through the placement of restorative material including crowns) could aid in curbing the increasing prevalence of ECC and avoiding an edentulous state in children. Shivaranjhany Sivakumar


[Objective] The aim was to study the expression of flavonoid prenyltransferase-like genes in Saccharomyces cerevisia.[Method] Using the Epimedium acuminatum as material,the flavonoid prenyltransferase-like gene(EaPT1) was cloned,and with the construction of recombinant plasmid which expressed in Saccharomyces cerevisia,the crude enzyme was detected by flavonoid substrate.[Result] An about 1 200 bp EaPT1 gene was obtained;through the SDS-PAGE detection,the Saccharomyces cerevisia which had be transformed in recombinant plasmid had as if EaPT1's expression product;there was no EaPT1 enzymatic activity in the crude enzyme detection.[Conclusion] It prepared the ground for the analysis of secondary metabolism of Epimedium acuminatum,specially the synthetic route of flavonoid organism.


A review of the nonrelativistic basic equations of MHD (magnetohydrodynamics) including their boundary conditions and dimensionless parameters is presented. The change of Ohm's Law for weakly ionized gases in strong magnetic fields is discussed. By use of the basic equations some characteristic phenomena of MHD are shown and explained physically. (tr-auth)


Some important thermal properties of steel grade adopted by the online slab quality diagnosis analysis mathematic model CISDI_SQDS ONLINE R2011,such as linear thermal expansion coefficient,critical stress/strain and latent heat,were discussed detailedly for their metallurgical physical essence and numerical calculation methods.The mathematic model was put into industrial application successfully,with reasonable computing results and reliable calculating process,which can obviously indicate that,the calculation methods of these thermal properties introduced by the model have reasonability and reliability to a great extent.


Objective:To explore the constitution of phlegm-damp type infertility patients and the action mechanism of Cangfudaotan Tang.Method:We compared the BMI,E2,corporin,leptin,thickness of endometrium between patient and healthy ones first.Then compared the BMI,E2,corporin,leptin,thickness of endometrium of before and behind treatment.Results:The phlegm-damp type infertility patients were obersity,had high level leptin and thin endometrium,with significant differences when compared with those of control group(P0.01).The Cangfudaotan Tang could decrease significantly the BMI,the level of leptin and increase significantly the thickness of endometrium after treament(P0.05).Conclusion:The phlegm-damp type infertility patients had the characteristic of obersity,high level leptin,thin endometrium.This study demonstrated that the Cangfudaotan Tang can improve conception by reducing BMI,adjusting the level of leptin and the thickness of endometrium.


For health-oriented diagnosis,a suspension bridge model was designed and manufactured.Based on the model,model test for girder,main cable and hangers of suspension bridge under damage condition was conducted.The variations of the structural response and characteristics(deflection and strain of stiffened girder,strains of main cable and hangers,and the natural frequencies) under damage condition were analyzed.The results show that(1) the sensitivity of the structural responses to girder damage is rather low and the correlation of the responses variations to damage location is also unconspicuous;(2) the static and dynamic structural response variations induced by main cable damage are remarkable and the variations give a good indication of correlation to both damage location and damage extent;(3)the responses variations induced by hanger damage also give a good indication of correlation to both damage location and damage extent,but the variations of deflection and strain of stiffened girder are comparatively small.


This paper proves that, if quantum communication and computation are available and the number of parties is given, the leader election problem can exactly (i.e., without error in bounded time) be solved with at most the same complexity up to a constant factor as that of computing certain symmetric functions on an anonymous network of any unknown topology. Together with a novel quantum algorithm that computes a certain symmetric function, this characterization yields a quantum leader election algorithm that is more efficient than existing algorithms.


In 1949, the Council of the Association of Anaesthetists announced the launch of an "investigation of deaths associated with administration of anaesthetic"' [1]. Two articles describing specific complications associated with death were published during the investigation [2, 3] but the complete report, "Deaths associated with anaesthesia' by Edwards et al. [4], was published in Anaesthesia in 1956 and is this month's 'Contemporary Classics'publication. The conclusion states:


Biosolids have been traditionally used as a beneficial resource in the agricultural industry. However, contaminants of emerging concern (CECs) threaten their reuse due to concerns of toxicity, bioaccumulation, and increased regulations on acceptable CEC concentrations in biosolids. The thermal treatment of biosolids has the potential to destroy/mineralize these contaminants as well as transform the biosolids into valuable biochar. However, the thermal processing of biosolids is highly energy intensive due to the energy costs associated with drying biosolids to the required moisture content for thermal processing. This article performs a brief review of the drying of biosolids from a physical and theoretical viewpoint. It also provides an overview of pyrolysis and gasification. It explains the impact that moisture can have on both the degradation of CECs and the products that can be obtained through the thermal treatment of biosolids. Additionally, model-based, lab-based, and pilot-scale examples of integrated drying and thermal treatment processes are reviewed. Key challenges, such as the need for co-pyrolysis and co-gasification, as well as the impact of biosolids composition on energetic viability, are identified.


The case histories presented in this paper illustrate the various marketing, technological and human factors requirements which influence the design of a relatively simple everyday artifact, the consumer package. During the past twenty years, package design has grown from modest beginnings to become one of the major areas of industrial design activity. Concerned with the protection, distribution, sales and use of products, the designer of the package must accommodate a number of different human interfaces, placing strong emphasis on the satisfaction of emotional as well as physical needs. Some packaging requirements are amenable to rational design solutions and the application of established human engineering criteria, but despite the growing use of a variety of research techniques, packaging relies, more than most other areas of industrial design, on limited empirical findings and the designer's intuitive interpretation of requirements.


The electrostatic interaction between emerging quantum-confined nanostructures with plasmonic structures is crucial for future biological applications. Water-soluble green fluorescent copper nanoparticles (Cu-NPs) were fabricated. We demonstrate that L-ascorbic acid is considered as a key to precisely control small Cu-NPs and the capability of the surface ligands, while cetyltrimethylammonium bromide is used as a stabilizing agent controls the particle growth, and stabilizes the nanoparticles. Water-soluble green fluorescent Cu-NPs are tunable through modification of the reaction periods.


Background: Malnutrition among Filipino children persists; underscoring the value of nutritional assessment procedures. In the Philippines, this is carried out at the local level in its annual Operation Timbang [weigh] (OPT or OPT Plus). Local government unit officials observed higher malnutrition prevalence rates in nutrition survey reports of the Department of Science and Technology's Food and Nutrition Research Institute (DOST-FNRI) compared with its OPT. A revisit of the OPT provided evidence on the comparability of the two data sets and sources of variance analyzed.
Objectives: 1) describe municipal level assessment of OPT in 10 barangays of Abra de Ilog municipality; 2) identify facilitating and hindering factors in OPT; and 3) compare OPT results with DOST-FNRI local nutrition survey in Abra de Ilog and identify potential sources of variance therefrom.
Methods: Primary data were collected using focus group discussions and key informant interviews. Height and weight data were collected using standard methods of anthropometry.
Results: The OPT/OPT Plus is the mass weighing of 0-71 months old children, including height measurements conducted during the first and fourth quarter of the year in Abra de Ilog. It was found that facilitating factors were availability of calibrated equipment, latest master list, local government support and budget. Lack of manpower, work overload, low honoraria, low work commitment, uncooperative mothers and high turnover of barangay [village] nutrition scholars hindered OPT implementation. The Abra de Ilog 2016 OPT Plus and the 4th quarter "OPT" reported lower malnutrition prevalence rates than the DOST-FNRI local survey.
Conclusions:  Significant differences in the two data sets could misguide program implementation. As an outcome of Sustainable Development Goal No. 2 of Zero Hunger, potential misclassification of nutritional status and misreporting of malnutrition prevalence rates have implications for the mapping of malnutrition, hence delivery of targeted nutrition intervention packages.


Objectives To evaluate the relationship of the new method of resuscitation and reducing the mortality of asphyxia in perinatal period neonate. Methods The resuscitations were divided into three groups according to different periods: resuscitation relying mainly on obstetrics, resuscitation relying mainly on obstetrics associated with cooperation of pediatrics, resuscitation relying mainly on pediatrics associated with cooperation of obstetrics. The incidence rate and mortality from asphyxia in neonate in 3 groups were compared. Results The total incidence rate and mortality of asphyxia in neonate were decreased annually in all groups. Differences of the rates between each group were significant (P0.05). Conclusions Since the new method of resuscitation was popularized, three cooperative models between the Obstetrical and Pediatrics department had the different incidence rate and mortality of asphyxia in neonate. The cooperative model of relying mainly the Pediatrics department associated with cooperation of obstetrics is more effective.


Security issues can have a significant negative impact on the business or reputation of an organization. In most cases they are not identified in requirements and are not continuously monitored during software evolution. Therefore, the inability of a system to conform to regulations or its endangerment by new vulnerabilities is not recognized. In consequence, decisions related to security might not be taken at all or become obsolete quickly. But to evaluate efficiently whether an issue is already addressed appropriately, software engineers need explicit decision documentation. Often, such documentation is not performed due to high overhead. To cope with this problem, we propose to document decisions made to address security requirements. To lower the manual effort, information from heuristic analysis and end user monitoring is incorporated. The heuristic assessment method is used to identify security issues in given requirements automatically. This helps to uncover security decisions needed to mitigate those issues. We describe how the corresponding security knowledge for each issue can be incorporated into the decision documentation semiautomatically. In addition, violations of security requirements at runtime are monitored. We show how decisions related to those security requirements can be identified through the documentation and updated manually. Overall, our approach improves the quality and completeness of security decision documentation to support the engineering and evolution of security requirements.


This paper provides calculation models of AEGIS/SCOPE2, a core calculation system of next generation. This paper especially focuses on the resonance calculation method of the AEGIS code, which has not been published yet. In the AEGIS code, effective cross sections in resonance region are generated from ultra-fine-group calculations utilizing tabulated collision probabilities for square pin-cells. In addition, the SPH method in the energy domain is used to preserve reaction rates in the energy-collapsed multi-group calculations. The validity of the resonance calculation method of the AEGIS code is verified through the comparison with the continuous energy Monte-Carlo calculation in pin-cell geometry. (authors)


Views on Alcohol In the U.K., Green (2004) found that, when comparing LEOs with PTSD to civilians with PTSD, more civilians increased their consumption of alcohol than did LEOs with PTSD. Emsley (1996) argued that, although alcohol and pub culture is a feature of the U.K. LEO's life, it is done moderately. However, in the U.S., 20% of LEOs were found to have abused alcohol. Notably, the alcohol use of U.S. LEOs was double that of the general U.S. population (Lindsay, 2008).


The invention discloses a data processing method and device and belongs to the technical field of computers. The data processing method comprises the steps that a template file is generated, wherein the template file comprises multiple data processing code blocks and template data, and the data processing code blocks are used for processing the template data; the template data in the template file are replaced by designated data to be processed, a processing file is obtained, and data processing code blocks in the processing file are used for processing the designated date; based on the multiple data processing code blocks, the designated data are processed. According to the data processing method and device, the characteristic that data processing codes of identical data processing operations of different data are similar is utilized, a developer does not need to input all the data processing codes, operation is easy and convenient, the workload of the developer is greatly lowered, unnecessary manpower resource waste is avoided, the probability of errors is lowered, and the development efficiency is improved.


The numerical control manufactureing center about tool storeroom of PLC Control is presented, the simatic S7-200 CPU224 PLC and EM221 (CN) are elected, the control program is projected based on analysis control request. The control program is made up of the current tool number recorded、 the tool number requested、 the turntable turning estimated and direction confirmed、 the conversion time and the dicator light glittered about tool, so the program is fine in instructue, good in reading and run faster in efficiency. It is very satisfied in application.


One of the main limitations of the goal model approach to formal requirement specification is the lack of representation of temporal constraints. Existing works in this domain have transformed goal models into state machines with the only motive of model checking them against temporal properties. The generated state machines could contain invalid state sequences that violate some property. In this paper, we aim to go one step further and generate a Kripke Transition System which is compliant with respect to a given set of temporal properties. We introduce the Safety and Liveness Compliance (SLC) framework which incorporates a compliance assurance mechanism within the model transformation process itself. This assurance mechanism ensures that the generated Kripke Transition System does not generate any counter-examples when checked against the predefined safety and liveness properties. We also present a qualitative comparison of our proposed SLC framework with the other related works.


In view of moving object detection is satisfactory with traditional methods in complex environment,an object detection method based on channel differencing combined with optical flow was proposed in this paper.Firstly,pre-processing including noise reduction and smoothing was introduced to enhance the useful information.Then the moving object was accurately detected and extracted by real-time channel-difference.Lastly,the proposed method combined with optical flow can detect true target and correct detection error by movement information.To improve the effect of detection,mathematical morphology was incorporated into the proposed method to wipe off noise and strain.The experiments show that this method can detect moving objects in image sequence quickly and accurately.


A novel ESPRIT based decorrelating DOA estimation for CDMA frequency-selective fading channels is proposed. The proposed algorithm has the advantages that the DOAs of the multipath signals can be estimated independently and all the other resolved multipath signal interference is eliminated. Simulation results show that the proposed algorithm estimates the DOAs of multipath signals effectively and accurately.


The problem of a herzian dipole in the presence of a dielectric sphere is solved by expanding the electromagnetic field in the vector spherical harmonics and imposing the appropriate boundary conditions. The solution is generalized to a N-layered sphere. The algorithm is programmed as the RAME (Radiation Analysis by Multipole Expansion) code by means of Matlab. Specific choice of the location of the dipole gives short computation time. The output includes near-and far-field plots and efficiency. The results have been compared with static solutions when applicable and good agreement was found. The analysis is extended to the arc antenna which is otherwise only numerically solvable. The theory of RAME is presented, followed by results for testing the program. Finally RAME results relevant to personal communications are presented.


Logical systems are often characterized as closure systems, by means of unary operators satisfying Reflexivity, Idempotence and Monotony. In order to capture non-monotone systems, Monotony can be replaced by Cumulativity, namely Restricted Cut and Cautious Monotony. This short note shows that in such a context, Restricted Cut is redundant.


Background: Healthcare organizations are becoming increasingly dependent on Information technology (IT) for the provision of routine services. IT failures within hospital systems can impact acute patient care, including emergency department (ED) closure and the cancellation of operations. This study aims to gain insight into the impact of hospital IT failures in the Netherlands on acute care delivery and to provide recommendations for future preparedness. Methods: This is a systematic scoping review of major acute care disruptions in Dutch hospitals between 2000 and 2020. Incidence of etiology, duration, ED diversion, and closure of multiple locations was evaluated. IT failures were included when associated with the closure of hospital departments and/or evacuations. Results: Thirty-nine IT failures resulting in acute care disruption were identified. The majority occurred between 2010 and 2020 (n=37, 95%). Of the 39 events, 33 (85%) were primary IT failures and were mainly caused by computer network and/or hospital software failure. Secondary events predominantly resulted from power failure. Most events (n= 36, 92%) were resolved within minutes to hours. All events were associated with an ED closure, 27 (69%) with an operating room (OR) stop and two (5%) with external hospital evacuation of one or more patients. Furthermore, 17 incidents (44%) involved multiple hospital locations, and seven (41%) of these involved closure of multiple locations with an ED. Conclusion: The impact of IT failures on acute care disruptions in the Netherlands has considerably increased since 2010. This stresses the urge to improve IT security and business continuity in todays hospitals.


The objective in establishment of BMT is to actualize the society welfare, both in terms of business application and comprehension of sharia economy. Financing is often the main problem faced by the community, particularlythe weak economic community. The existence of BMT El-Munawar is significant to get financing source (capital) help. This study aims to analyze the BMT financing ability to improve members' economics. This research applied descriptive qualitative approachto describe and analyze the problems, and describe the research finding through interviews and observation and others sources. The results of this study indicated that the implemented financing by BMT El-Munawar could improve the members' economic, where the increase reaches 99%.and This was proven through interviews to the members, who said that the tuition fee their children education could be paiddue to the BMT help. The members also commented financing distribution wasvery good and had a positive impact. However, the study also found negative findings, are a complaint from the member to the BMT asking for compulsory savings if a member submits a financing above IDR 1.000.000.


Objective To compare the ferulic acid content of Siwu Decoction using the shattering extraction and traditional decoction method.Methods The ferulic acid was analyzed on an Inertsil ODS C18 column(250 mm×4.6 mm,5 μm),by using acetonitrile-1 g·L-1 phosphoric acid solution as the mobile phases;the column temperature was 30 ℃;the detection wavelength was at 316 nm.Results The content of ferulic acid in decoction using the shattering extraction was much higher than the traditional method of decocting and boiling machine decoction.Conclusion Wet preparation method,as a new method for preparation of traditional Chinese medicine decoction,deserves further study.


The invention relates to a voltage aging method of an X-ray tube. The X-ray tube is quickly and stably fixed in a voltage aging process, so that the problem of position deviation of the X-ray tube in the voltage aging process is effectively solved, a constant distance between the X-ray tube and an oil tank shell and outside air is kept all the time and is within a protection range of insulating oil, discharge is avoided, and the safety is increased.


The frustrated quantum spin-one-half Heisenberg model on the triangular and kagome lattices is mapped onto a single species of fermion carrying statistical flux θ=π. The corresponding Chern-Simons gauge theory is analysed at the Gaussian level and found to be massive. This provides a new motivation for the spin-liquid Kalmeyer-Laughlin wave function. Good overlap of this wave function with the numerical ground state is found for small clusters


Genetic improvement to develop varieties with high yield potential and resistance/tolerance to abiotic and biotic stresses with acceptable end use qualities is the most viable and environment friendly option to increase wheat yield in a sustainable fashion. In vitro haploid production followed by chromosome doubling greatly enhances the production of complete homozygous wheat lines in a single generation and increases the precision and efficiency of selection process in wheat breeding. It also enables the detection of linkage and gene interactions, estimate genetic variance and the number of genes for quantitative characteristics, produce genetic translocations, substitutions and chromosome addition lines, and facilitate genetic transformation and mutation studies. Wheat cultivars developed from doubled haploids using anther-culture and maize induction systems have been released for cultivation in both developed and developing countries. In this review, the origin and production of haploids, techniques in anther-culture and wheat x maize wide crosses, and their application in wheat breeding are summarized.


Abstract Present work deals with the pseudocapacitance of carbon nanomaterials modified by nitrogen heterosubstitution and electroactive polymers taking place in ionic liquids and lithium salts solutions in organic media. It is shown that N-doped materials, where nitrogen atoms are located within grahene layers, due to excess of electrons and variation of specific cooperation demonstrates higher capacitance than non-doped samples in the whole range of voltage applied, restricted by electrochemical stability window of electrolyte. The values were found to mostly depend on correlations of the ions size and pore size in the material. For composites of carbon nanotubes with electroactive polypyrrole, obtained electrochemically in the ionic liquid, the capacitance can increase more than 3 times due to reversible red-ox processes. In case of high purity of components there were no polymer degradation process observed. The possibility of implementation of mixed electrolytes based on solutions of high voltage ionic liquids with symmetrical electrochemical stability window and lithium salts in dry acetonitrile for realization of pseudocapacitance effect together with ion-pore size correlations is proposed.


The most common fault in GIS is the partial discharge of insulator before the full breakdown. On-line monitoring of uhf partial discharge is an effective means of partial discharge monitoring. The anti-jamming performance of monitoring system at the present time is poor, false positives, non-response rates higher problem. We design a set of uhf partial discharge of intelligent monitoring and fault diagnosis system. In order to improve the accuracy of the test, We need to calibrate sensor. Then the UHF electromagnetic wave radiated by partial discharge of GIS equipment is monitored by sensors, and the monitoring data is transmitted to expert database analysis system in real time by means of Ethernet data transmission. By intelligently identifying the possible partial discharge defects in GIS, the types of defects in GIS can be found in time and major accidents can be avoided.


A two-year-old girl was presented with vesiculobullous eruptions initially on the palmoplantar region then extend to the whole body (Figure 1). On examination multiple tense vesicles, bullae and crusted erosions touching the whole tegument were seen. Nikolsky's sign was negative. Mucous membrane examination revealed erosions over buccal mucosa and hard palate. There was no regional lymphadenopathy. Histopathological examination revealed subepidermal blister and a mild inflammatory infiltrate on the dermis. Direct immunofluorescence (DIF) showed linear deposition of IgG and C3 at the dermoepidermal junction. The specific blood test searching for cutaneous basement membrane antibodies was positive. Based on clinical, histological and immunopathological criteria, the diagnosis of childhood bullous pemphigoid was made. The patient was treated with prednisone 1 mg/kg/ day associated with methotrexate 5 mg/week which led to a rapid resolution of the skin lesions within two months. Topical steroids and dapsone were ineffective in this case.


There is a quiet revolution in the web application area. Instead of using hundreds of heavy web-servers in expansive server farms, only one powerful server is used for the black Friday super-business at companies like Walmart. The secret behind it is the base software that is being used: a JavaScript engine called NodeJS for server applications. In contrast to heavy weight multitasking procedures of the operating systems with a maximum of about 200 processes at one time, NodeJS uses its own light weight multitasking in combination with Google ́s performance optimized JavaScript-V8 engine with up to 1 Million processes on the same machine. This paper analyses the options for using this multitasking power for discrete simulation. The additional benefit of using JavaScript on a webserver is the easy integration in web-oriented environments.


1 Comparisons were made of the uptake and inotropic effects of concentrations of 0.1 μm of digitoxin and its cleavage products digitoxigenin‐bis‐digitoxoside, digitoxigenin‐mono‐digitoxoside and digitoxigenin in the isolated perfused hearts of guinea‐pigs. 2 Digitoxin produced the greatest inotropic responses in this series, while the sequence of cleavage products produced progressively smaller responses. 3 The uptake of digitoxin was significantly higher than that of the three metabolites, and the uptake of metabolites became progressively less with cleavage. The highest binding in each case was found in the microsomal fraction. 4 The uptake of all four digitaloids was reduced when the potassium in the perfusion medium was increased.


Lara Campbell, Dominique Clement, and Gregory S. Kealey, eds. Debating Dissent: Canada and the Sixties. Toronto: University of Toronto Press, 2012. 374 pp. Notes. Index. $29.95 sc. We are now as distant from the 1960s as that decade was from the First World War, but the past is always present. Indisputably, the tumultuous 1960s were culturally transformative. In the trope of Debating Dissent, "the Sixties" were more than a decade; they were an idea and a phenomenon that transcended a fixed period. They expressed temperaments that went against the grain of conventional wisdom, challenging the nostrums of established authority and refusing to defer. This collection of 13 essays with an introduction by two of the editors is the latest book in the Canadian Social History Series under the general editorship of labour historian Gregory S. Kealey. The contributors do not so much debate as they document dissent. Some of the authors lived through the events they dissect (although some veterans of the drug-induced flower power counterculture claim that if you can remember the Sixties, you were not there). The younger authors are intrigued by the era's permissiveness; the Sixties spawned much of the contemporary academic discourse in which they engage on subjects such as the environment, Aboriginals, race, and gender. Some of the chapters are case studies--the 1969 and 1971 riots at Sir George Williams (now Concordia) University and Vancouver's Gastown, and the confrontations involving Blacks in Nova Scotia. Other chapters offer broader surveys --of wildcat strikes, English Canadian and Quebec nationalisms, the drug culture, the women's movement, and the rise of faculty power at universities. This last story, stretching for two decades beginning in the early 1950s, speaks to the elasticity of the Sixties as an epoch. So too do the photographs that preface each chapter. Of the 13 images, five are from either the 1950s or the 1970s. The cover illustration of a longhaired protester forcibly thrown into a paddy wagon by police officers has two children relaxing on the street curb less than five feet away, their attention directed elsewhere. Students of ethnicity will find thin gruel in these studies. Unless their interest is Canada's Blacks (West Indian and Nova Scotian), Aboriginals, or Quebecois, they will encounter only a gratuitous mention of the Jewishness of an American draft dodger and a brief reference to the assistance extended to Halifax's Africville residents by the Jewish Labour Committee. I would have welcomed a chapter that detailed the rise of multicultural discourse, triggered by the hearings of the Royal Commission on Bilingualism and Biculturalism. What was termed the "third force" in Canada spoke out. Largely located in western Canada, it was composed mainly of second--and third-generation Europeans who considered their cultural heritages denigrated by the assumptive title of the Commission. …


We report Mössbauer and resistivity measurements at 2.3 and 5.6 GPa and at room temperature for the 57 Fe 0.03 Cr 0.97 Sb 2 system using a diamond anvil cell. The observed isomer shift and quadrupole splitting in Mössbauer data can be interpreted in terms of a first-order structural phase transition from marcasite-type orthorhombic to pyrite-type cubic at about 6 GPa. A transformation from the high-spin to the low-spin state of Fe 2+ is also observed at this pressure. Electrical resistivity measurements up to 8 GPa on the system confirmed a first-order pressure-induced structural transition.


A single-finger physical model of 180 nm gatelength and 75 μm gate-width AlGaN/GaN HEMTs is described including lateral structure and vertical material parameters. The Farahmand Modified Caughey Thomas fitting function and the Monte Carlo model are used to express the 2DEG mobility in low and high field respectively. Then DC characteristics is simulated and the initial condition generated by self-heating effect is determined under DC bias. Electromagnetic-thermal (EM-T) coupling mechanism during the whole process is analyzed and the AlGaN/GaN HEMT structure is calculated combining with equations in electromagnetic field, microelectronics and thermal field under different RF input signals. Finally, high frequency characteristics of the device is obtained. The result shows that the highest junction temperature is 126 °C under -2 V gate voltage, 25 V drain voltage and 16 dBm CW RF input signal. The current gain cutoff frequency (fT), the maximum frequency of oscillation (fmax) and the maximum available power gain (MAG) at 40 GHz decrease 13%, 17% and 18%, respectively, at 16 dBm by contrasting to 8dBm. 


Abstract : A description, with source deck listing and flow charts, of four improvements made to the Argonne National Laboratories' ABACUS-NEAREX program for computing nuclear cross-sections for neutron scattering problems. NEAREX uses the Hauser-Feschbach calculation scheme and the optical potential model. A problem that caused machine overflow when protons of very low kinetic energy were involved was solved by setting the transmission coefficient to zero, thus avoiding the wave function calculation. (This is a reasonable approximation when the Gamow penetration factor is extremely small.) The original code set the neutron mass equal to 1; the exact value is now used, with necessary changes in the reduced mass correction. Other changes involve resetting certain variables to zero before each of successive computer runs, and properly restoring the optical well parameters when the original code fails to make such a restitution in part of the gamma computation. (Author)


Primitive neuroectodermal tumors (PNET) are a group of malignant tumors composed of small round cells of neuroectodermal origin that affect soft tissue and bone. PNET have a rare incidence, occurring usualy in children and adolescents, rarely in adults. In this case report are focus of Peripheral primitive neuroektodermal tumors. Peripheral primitive neuroectodermal tumors (PNETp) are a group of aggressive malignancies that most commonly present in multiple tissues and organs including kidney, adrenal, bladder, liver, small intestine, colon and rectum, with a preferred location within the chest area (thoracopulmonary region), in the limbs and around the spine, but rarely, in the head and neck area. Here we present a case of the maxilla sinistra PNETp in a 17-year-old girl and we discuss the clinical features, histopathological characteristics, diagnosis, and treatment.


A fibrogenic process mainly consequent to reiterated tissue damage is characteristic of different chronic disease affecting the liver, the pancreas and the intestine. Although the general mechanisms l


Sir,

The relationship of sodium intake to blood pressure and prevalence of hypertension has remained somewhat controversial for many years, despite a large body of evidence from experimental and epidemiological studies across populations supporting a positive correlation between sodium and blood pressure. The report by Cheung et al .1 of a positive correlation between diastolic blood pressure and urinary sodium excretion in 70 hypertensive Hong Kong Chinese patients tends support to the findings of an earlier and much larger nationwide survey of blood pressure, hypertension and sodium intake in 950 356 men and women carried out in mainland China in 1991.2

A positive within‐population relationship between sodium intake and blood pressure has been demonstrated in several studies in mainland China, using values …


Abstract : Spacecraft and space stations orbiting the earth for long periods of time will incur many malfunctions requiring redundancy or orbital maintenance. Redundancy will suffice for the shorter periods while maintenance becomes a necessity in the long run. For maintenance to become a reality it must be both system and cost effective. It will never become effective unless the spacecraft is maintainable, spares are interchangeable, and man can make in-space repairs. Current programs are slowly advancing the technologies but a concentrated, comprehensive program is needed to make maintenance a reality reasonably soon. (Author)


Mangosteen rind (MSR) (Garcinia mangostana L.) is a predominant component of the fruit contributing to 62%
of the whole fruit. However, utilization of the same for the preparation of health products was not explored due to its
sensorially less acceptable parameters. Differential extraction in different polarity solvents of MSR was done and
evaluated their acceptability for product preparation. Current study thus is a detailed investigation on bioactivity profiling
of MSR fraction and utilization of the same for health product preparation. Among various extracts, 70% ethanol
(70%AE) yielded the maximum (15g/100g). Xanthone:Phenolic ratio was 1: 2.8, in 70%AE as opposed to hot water
extract – HWE and 50% AE, which contained Xanthone:Phenolic ratio of 1:1.4/5. Higher the phenolic content obviously
reduces the bitterness of Xanthones. 70% AE contained phenolics 60.08± 0.213 mg/g and xanthones 22.56± 0.317
mg/g. HPLC analysis revealed a spectrum of phenolic acids such as gallic, chlorogenic, caffeic, epicatechin, catechin
and ferulic acids at various levels. Potent Free Radical Scavenging (FRS) activity, cytoprotectivity, DNA protectivity,
H+K+ATPase inhibitory (PPAI) activities were observed in 70% AE. Gallic/tannic acid appear to contribute to antioxidant
activity; while ferulic acid was responsible for PPAI activity in 70%AE. Among xanthones, although


This paper presents the requirements for automatic control of a turbojet engine in order to meet the needs of military aviation and to realize the full operational performance of the engine. The author describes how these requirements were established, and outlines the recommended approach to the design of an optimum engine power control.


A convenient and environmentally attractive one-pot two-step process for the synthesis of β-adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.


Moral resilience, the ability of an individual to preserve or restore integrity in response to moral adversity, draws on targeted scholarship of the broader concept of resilience in other contexts. This chapter builds on definitions in the literature and qualitative analysis of clinicians' definitions of moral resilience in order to outline the key attributes of moral resilience. The foundation of moral resilience is personal and relational integrity. The attributes of self-regulation and self-awareness, such as mindfulness, buoyancy, moral efficacy, and self-stewardship, support the preservation or restoration of integrity. These attributes are defined and illustrated with quotes from clinicians. Taken together, these attributes constitute a conceptual basis for moral resilience.


Background: Decision aids provide balanced information about the benefits and risks of treatment options and improve the match between patient preferences and the treatment received. Objective: To assess the impact of a decision aid regarding the treatment options for patients with localized prostate cancer. Methods: A 2-arm randomized controlled trial was used to compare booklet patient decision aid (intervention group n = 61) with standard information for localized prostate cancer (control group n = 61). The study was conducted at 3 hospitals between 2011 and 2013. The main outcome measures were knowledge, decisional conflict, satisfaction with the decision-making process, and coping. Results: The respective mean Decisional Conflict Scale scores before and after the intervention were 53.0 ± 16.9 and 31.2 ± 10.2 in the intervention group and 49.1 ± 13.7 and 51.7 ± 13.3 in the control group (P < .001). Mean Knowledge scores were 38.6 ± 16.5 and 75.7 ± 19.0 in the intervention group and 42.0 ± 17.6 and 49.9 ± 16.0 in the control group (P < .001). Mean Satisfaction With Decision Scale scores were 81.1 ± 8.92 and 95.7 ± 6.89 in the intervention group and 82.5 ± 12.0 and 79.3 ± 10.3 in the control group (P < .001). Conclusions: Decision aid not only improved patient knowledge about localized prostate cancer and its treatment and their satisfaction with decision making but also decreased their decisional conflict. Implications for Practice: Decision aid represents a rather innovative approach for a health insurance fund to develop and offer this format of information and decision support. This opens a new field of study for nurses to empower patients in the decision-making process and develop new roles in this area.


Surface with micro-porous layer can enhance the boiling heat transfer efficiency of tube. The novel nucleate boiling tubes were manufactured by sinter-bonding metal particles on the outside surface. Two conventional bare tube reboilers were revamped with the novel tubes. Industrial application revealed that the revamps effectively increased the heat duty of reboilers with small heat transfer area and reduced heat transfer temperature difference across the heat exchanger. Porous surface tube was beneficial to heat transfer and operating cost.


Abstract : The purpose of this project is to conduct DoD high priority research in: vascular injury, pain, and airway management. These studies will extend evidenced-based prehospital interventions as well as populate the National Trauma Research Repository (NTRR). During the initial year, subcontracts have been issued, IRB approvals were secured. One study has HRPO approval and is enrolling subjects and the other is pending HRPO approval. The trauma repository and airway simulator projects are on schedule. There are no major finding or results at this time.


Primary hyperparathyroidism is characterized by increased synthesis and release of parathyroid hormone, which produces an elevated serum calcium level and a decline in serum inorganic phosphates. Asymptomatic patients are frequently diagnosed due to screening by automatic multi-chemistry panels. The vast majority of cases of primary hyperparathyroidism (80–85%) are due to single or multiple hyperfunctioning adenomas. Hyperplasia of several or all parathyroid glands accounts for approximately 12–15% of cases, while parathyroid carcinomas occur in only 1–3% of cases of hyperparathyroidism. In general, parathyroid adenomas larger than 500 mg can be detected scintigraphically. Recently, Tc-99m sestamibi has allowed detection of hyperplastic glands, although with less sensitivity than adenomas. Dual phase or double phase imaging refers to utilizing Tc-99m sestamibi and acquiring early and delayed images. Dual isotope or subtraction studies refer to protocols using two different radiopharmaceuticals for imaging acquisition.


The rapid development of information technology makes electronic products updated each pass-ing day. Here we introduce MagicEyes MP2530F innovator with dual ARM9 processors. According to the unique structure of MP2530F,we transplanted Linux OS and Qtopia4.3 phone GUI with Mplayer to MP2530F innovator using the bottom-up strategy. In addition,the YAFFS2 file system based on NAND Flash is produced to test the system performance. With the above means a handhold multimedia intelligent terminal is finally realized.


Chemical trapping of water and terminal OH groups in nonionic micelles of hexaoxyethylene monododecyl ether, C12E6, by an aryl cation formed by spontaneous decomposition of an aggregate-bound 4-hexadecyl-2,6-dimethylbenzenediazonium ion, 16-ArN2+, demonstrates that the interfacial region of a C12E6 micelles is "wet" and that hydration of interfacial ethylene oxide groups depends on both surfactant concentration and temperature. Product yields are used to estimate hydration numbers of C12E6 micelles by assuming that the selectivity of the reaction in micelles is the same as that of its short chain analog 2,4,6-trimethylbenzenediazonium ion, 1-ArN2+, in aqueous oligooxyethylene glycol solutions. The hydration numbers are found to decrease gradually with increasing C12E6 concentration at 40 °C from 3.5 at 0.45% (0.01 M) C12E6 to 2.5 in 54% C12E6, just before the lamellar phase region, and to 0.84 in 82.5% C12E6, above the lamellar phase region. The hydration numbers also decrease linearly with increasing tem...


Case Report: Chronic hyponatremia defined as serum sodium concentration <135 meq/L lasting > 48 hr is rare in full term neonates. We report chronic hyponatremia in a neonate secondary to corticosterone methyl oxidase type II (CMOT II) deficiency. A 4 weeks old full term male neonate presented with failure to thrive associated with serum sodium of 122 meq/L. His diet included 22 kcal/oz. formula. He had 4–6 wet diapers daily with no vomiting or diarrhea. On PICU admission, he had stable vital parameters: HR: 154/minute, BP: 79/54 mm Hg, with no clinical signs of dehydration or fluid overload and normal external genitalia. His investigations revealed hyponatremia: 122 meq/L, hyperkalemia: 5.8 meq/L, serum osmolality: 267 mosm/kg, normal anion gap and renal functions. He was placed on 26 kcal/oz. formula feeds and 1 meq/kg sodium supplementation q 3 hourly that gradually improved his weight and serum sodium to 130 meq/L. His newborn metabolic screening test was negative for congenital adrenal hyperplasia. Further studies revealed normal serum cortisol, aldosterone, thyroid hormone levels, normal kidney anatomy on ultrasound and negative sweat chloride test. His urinalysis revealed renal salt wasting with urinary sodium:68 to 126 meq/L and urinary osmolality of 212 mosm/kg. Further work up revealed markedly elevated serum renin levels (95.2 ng/ml/hr; normal: 2.4–37 ng/ml/hr). Preand 60 min post-ACTH stimulation levels revealed persistently low aldosterone levels [preACTH: 2 (normal: 5–90) and post-ACTH: 2.4 (normal: 5–166)] and significantly elevated 18-Hydroxycortisone: Aldosterone ratio [(pre-ACTH: 37 (normal: 1.3–5) and post-ACTH:117.9 (normal: 2–13)]. Based on these results, he was diagnosed with CMOT II deficiency and initiated on 9 alfa-fluorohydrocortisone therapy that led to improvement of his serum sodium: 140 meq/L and weight gain. CMOT II is an adrenal enzyme that is responsible for the final step of aldosterone synthesis. CMOT II deficiency although rare, should be considered in neonates with persistent hyponatremia when other causes are ruled out.


Purpose To observe the proliferative changes of myoepithelial cells within atrophic gland after the ligation of rat parotid duct with double immunhischemical staining.Methods The parotid duct of Wistar rat was ligated to establish an animal model,and then atrophy of the right parotid developed.The histological changes of parotid glands were examined by hematoxylin-eosin(HE) staining during each step of glandular atrophy at the time of 0(control),1,3,5,7,14,21,30,60,90,120,150,and 180 days after ligation.Immunohistochemical double staining was performed to quantitatively analyse the changes in number,proliferation rate and distribution of myoepithelial cells during atrophy of the rat parotid gland.Results Histological observation showed apoptosis of acinar cells and formation of a large number of duct-like structures,fibrous tissue hyperplasia and inflammatory cells infiltration after ligation.Quantitative analysis of immunohistochemical staining results showed that: on the third day after duct ligation,the myoepithelial cells proliferated rapidly,the proliferation rate reached a peak value on the fifth day and then decreased,on the 30 ~ 150 days,the proliferation rate was maintained at a low level.It was then difficult to observe the proliferation of myoepithelial cell and the myoepithelial cell number was significantly decreased.Conclusions Myoepithelial cells proliferate rapidly up to day 5 after ligation,then followed by gradual increase at a low level in 30 ~ 50 days,and at last there is a rapid decrease after the total number reached the peak in 180 days.


A 53‐yr‐old woman presented with a left upper quadrant abdominal mass attached to the body of the pancreas. Fine‐needle aspiration (FNA) yielded cyst fluid containing numerous benign, mature squamous cells, keratin debris, and inflammatory cells. The diagnosis of dermoid cyst was subsequently rendered on the resected specimen. The cytologic and histologic features are presented. FNA cytology proves to be a valuable diagnostic adjunct in the preoperative evaluation of a patient with dermoid cyst of the pancreas.


Contents: Introduction Religious America, secular Europe? Variation1: contrasting histories Variation 2: different intellectual traditions Variation 3: institutional carriers Variation 4: social difference So what? Policy implications Bibliography Index.


HONOLULU, Oct. 21 — Both houses of the legislature voted to day to over-ride Governor Poin dexter's veto of Senate Bill 44, ap propriating $5,000 to defray the expenses of Delegate Sam K ing in returning from Washington, D. C., a t the request of the senate. This action was taken by the senate shortly before adjourning today and came after the senate had orginally voted to sustain the governor's veto. The motion to over-ride the ve to was lost when the governor's action was sustained by a vote of 9 to 5 in the senate earlier today. A fte r a short recess, however, a motion to reconsider action was carried and the senate voted 10 to j 4 to override the veto.


The invention discloses a detection method and apparatus for an unlicensed vehicle. The method comprises: a vehicle in a video is detected and a vehicle sub image in the video is extracted; pretreatment is carried out on the detected sub image; image edge extraction is carried out on the sub image after the pretreatment; for an edge point, a sub image of a small area near the edge point is extracted and a color feature of the sub image is extracted; a vehicle color model is used for carrying out determination and whether the extracted sub image is a candidate license plate area is detected, all candidate license plate areas meeting the requirement are detected, and an area with the best matching effect among all candidate license plate areas is found and is determined as a license plate area; and if no license plate area is detected, the vehicle is determined to be an unlicensed vehicle. Therefore, a clear license plate can be identified and adaptability to the blurred license plate is also high, so that the license plate identification rate is improved and the effect of detection on the unlicensed vehicle is good.


The performance of the Eulerian gyrokinetic-Maxwell solver code GYRO is analyzed on five high performance computing systems. The analysis is based on the output of embedded wallclock timers, floating point operation counts collected using hardware performance counters, and traces of user and communication events collected using the profiling interface to Message Passing Interface (MPI) libraries. Custom scripts were used to extract results from these data. The paper discusses what was discovered via this manual analysis process, at what cost, and what aspects of the performance were not easily examined by this approach.


Let (𝐵(𝑡))𝑡∈[0,1] be the linear Brownian motion and (𝑋𝑛(𝑡))𝑡∈[0,1] the (𝑛−1)-fold integral of Brownian motion, with 𝑛 being a positive integer: 𝑋𝑛∫(𝑡)=𝑡0((𝑡−𝑠)𝑛−1/(𝑛−1)!)d𝐵(𝑠) for any 𝑡∈[0,1]. In this paper we construct several bridges between times 0 and 1 of the process (𝑋𝑛(𝑡))𝑡∈[0,1] involving conditions on the successive derivatives of 𝑋𝑛 at times 0 and 1. For this family of bridges, we make a correspondence with certain boundary value problems related to the one-dimensional polyharmonic operator. We also study the classical problem of prediction. Our results involve various Hermite interpolation polynomials.


This paper summarizes the progress on immunoregulation effect of antipyretic-antidotal Chinese Medicine on organ and tissues,cellular and molecular level;antipyretic-antidotal Chinese Medicine is of better effect on resisting Toxin and heat-Toxin.The concept of the whole should be emphasized in the research of Chinese Medicine.


To investigate whether the amount of Wharton's jelly in non‐malformed fetuses with a single umbilical artery is different from that of fetuses with a normal umbilical cord.


Background: Though clinicians provide appropriate care by clinically differentiating between acute myocardial infarction (AMI) and non-thrombotic cause of troponin elevation (NTTE), documentation a...


Extetensive studies conducted by the Research Institute for Fragrance Materials (RIFM) show that the musks as used are safe for consumers and the environment. The industry has submitted extensive scientific dossiers to the Scientific Committee of Cosmetology, which advises the European Commision, and is convinced that the amount and quality of the safety data will be sufficient to answer all questions raised by the European Commission. The International Fragrance Association (IFRA) and the European Flavour and Fragrance Association (EFFA) zre willing to cooperate with the authorities towards ensuring that the fragrance components as used are safe


In this work, a signal amplification strategy was designed by the fabrication of a highly sensitive and selective electrochemical sensor based on nickel–copper–zinc ferrite (Ni0.4Cu0.2Zn0.4Fe2O4)/carboxymethyl cellulose (CMC)/graphene oxide nanosheets (GONs) composite modified glassy carbon electrode (GCE) for determination of omeprazole (OMP). The one-step synthesized Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs nanocomposite was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy and X-ray diffraction techniques. Then, the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE was applied to study the electrochemical behavior of the OMP. Electrochemical data show that the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE exhibits superior electrocatalytic performance on the oxidation of OMP compared with bare GCE, GONs/GCE, CMC/GONs/GCE and MFe2O4/GCE (M = Cu, Ni and Zn including single, double and triple of metals) which can be attributed to the synergistic effects of the nanocomposite components, outstanding electrical properties of Ni0.4Cu0.2Zn0.4Fe2O4 and high conductivity of CMC/GONs as well as the further electron transport action of the nanocomposite. Under optimal conditions, the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE offers a high performance toward the electrodetermination of OMP with the wide linear-range responses (0.24–5 and 5–75 μM), lower detection limit (0.22 ± 0.05 μM), high sensitivity (1.1543 μA μM−1 cm−2), long-term signal stability and reproducibility (RSD = 2.54%). It should be noted that the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE sensor could also be used for determination of OMP in drug and biological samples, indicating its feasibility for real analysis.


In this paper, archaeological and epigraphic evidence is scrutinized, pertaining to indigenous communities in the hinterlands of Trieste in the Late Prehistoric and Early Roman period. Not only the elements of "tongue duree" of the settlement pattern, but also the mechanisms of change are considered. The key mechanism, which triggered the final collapse of the social structure of indigenous communities there, is identified in the act of granting Latin citizenship, such as documented in the mid-second century A.D. by the honorary inscription to L. Fabius Severus (I. It. X 4,31), involving the communities of the Carni and Catali (or Subocrini).


PURPOSE: A vacuum system with a load-lock chamber is provided to support a substrate set of only two rows of substrates and to continuously cool the substrate without interrupting the operation of the load-lock chamber. CONSTITUTION: A vacuum system provides for quick evacuation and venting of a load-lock chamber(112) to provide a continuous feed load-lock chamber(112). Then, the vacuum system includes a transfer chamber(102), one or more processing chambers(106) connected to the transfer chamber(102), a substrate handling robot(103) disposed in the transfer chamber(102), and at least one load-lock chamber(112) connected to the transfer chamber(102) and having one or more substrate support members for supporting one or more stacks of only two substrates per stack. Additionally, the vacuum system provides a staging, or storage rack associated with or integrated with the load-lock chamber. More particularly, the staging or storage rack may be located outside the transfer chamber(102) and accessible by a staging robot(113) serving the load-lock chamber(112). The staging or storage rack may temporarily store processed substrates for cooling of the substrates prior to replacing the substrates within substrate cassettes during idle time of the staging robot(113).


We apply regret theory, an axiomatic behavioral theory, to derive closed-form solutions to optimal currency hedging choices. Investors experience regret of not having chosen the ex post optimal hedging decision. Hence, investors anticipate their future experience of regret and incorporate it in their objective function. We derive a model of financial decision-making with two components of risk: traditional risk (volatility) and regret risk. We find results that are in sharp contrast with traditional expected utility, loss aversion, or disappointment aversion theories. We discuss the empirical implications of our model and its ability to explain observed hedging behavior.


This study examined the differences between attentional styles and anxiety measures for Division I and lll soccer players. Male varsity soccer players (N = 88) completed the Test of Technical and Tactical Soccer Attentional Style (3TSAS) and the Soccer Situation-Response lnventory of Anxiousness (SS-R|A). To gain measures of test-retest reliability, 22 subjects were re-administered the testing instruments following a 3-5 week period. The 3TSAS was composed of 75 specific soccer situations presented on video and described on a questionnaire form. Each situation on the 3TSAS represented one of eight attentional foci (BET, BlT, NET, NlT, OET, OlT, REDE, and REDI). Subjects responded to each of the situations on a S-point Likert scale to represent the degree each situation was a reflection of her/his behavior. Test-retest reliability of the 3TSAS scales ranged from.38 to.73, while the SS-RIA responses ranged from.18 to .92. Coefficient alpha reliabilities for the 3TSAS scales ranged from .44 lo .79. Multivariate analyses of variance revealed significant (g < .05) differences between Division I and lll players with both the 3TSAS and the SS-RIA. Analyses of variance revealed that each of the eight STSAS scales differentiated Division I and lll players, whereas only three of the SS-RIA responses were able to do so. Both Division I and lll players were able to attend to the task demands of soccer, but only Division I players were able to successfully attend to the subtleties of the more complex skills. Division I players were also able to appraise negative anxiety eliciting situations in soccer more positively than were Division lll players. AT~「 EN丁10NAL AND ANXIETY MEASURES OF DIVIS10N I AND‖ I SOCCER ATHLEttES A Thesis Presented to the Faculty of the Division of Health, Physical Education, and Recreation Ithaca College ln Partial Fulfillment of the Requirement for the Degree Master of Science by Gregory Allister Brown December 1991 Division of Ithaca College Health, Physical Education, and Recreation Ithaca, New York CER丁1日CATE OF APPROVAL MASttER OF SCIENCE ttHESIS This is to certify that the Master of Science Thesis of Gregory Allister Brown submitted in partial fulfillment of the requirements for the degree of Master of Science in the Division of Health, Physical Education, and Recreation at lthaca College has been approved Thesis Advisor: Committee Member: Candidate: Chairman, Graduate Programs in Physical Education: Dean of Graduate Studies:


One current problem with laser radar point data classification is building and urban terrain segmentation, this paper proposes a point cloud segmentation method base on PCL libraries. PCL is a large cross-platform open source C++ programming library, which implements a large number of point cloud related efficient data structures and generic algorithms involving point cloud retrieval, filtering, segmentation, registration, feature extraction and curved surface reconstruction, visualization, etc. Due to laser radar point cloud characteristics with large amount of data, unsymmetrical distribution, this paper proposes using the data structure of kd-tree to organize data; then using Voxel Grid filter for point cloud resampling, namely to reduce the amount of point cloud data, and at the same time keep the point cloud shape characteristic; use PCL Segmentation Module, we use a Euclidean Cluster Extraction class with Europe clustering for buildings and ground three-dimensional point cloud segmentation. The experimental results show that this method avoids the multiple copy system existing data needs, saves the program storage space through the call of PCL library method and class, shortens the program compiled time and improves the running speed of the program.


The Coordinate Price Pressure Index (CPPI) measures the incentives of two competitors to engage on a specific kind of Parallel Accommodating Conduct (PAC). Specifically, it measures the incentives of a given firm to initiate a unilateral percentage price increase, with the expectation that at least one of its competitors will follow it. Using a large set of simulated economies, we measure the accuracy of the index in terms of predicting the impact of a merger on firms' incentives to engage on PAC. In addition, we propose two alternative indexes that incorporate the positive pricing externalities existent between substitute brands produced by the merged firm. The results suggest that the original index displays a good performance when predicting the direction of the change on firm's incentives to engage in PAC, but only in mergers with low values of the diversion ratios between the merged firm brands. However, the percentage of cases with Error Type I is not negligible. In addition, it is shown that both alternative indexes dramatically outperform the original one in terms of predicting mergers with a significant anticompetitive impact.


9091 Background: Few studies have evaluated the gender difference of vulnerability and geriatric syndromes (GS) among cancer survivors. Methods: Using 2003 Medicare Current Beneficiary Survey, we applied multivariable logistic regression to evaluate the association of gender with vulnerability and GS among cancer survivors. Vulnerability is measured by Vulnerable Elders Survey-13 (VES-13), which is calculated from age, self-rated health status, difficulty with physical activities and functional activities. Vulnerability is defined by a VES-13 score of 3 or higher. 8 common geriatric syndromes were assessed: sight trouble, hearing trouble, nutrition problem, incontinence, falls, depression, memory loss and osteoporosis. Cancer survivors are defined as patients with cancer diagnosed more than one year ago. Results: Among the 1,883 cancer survivors, 749 (40.0%) were male; 1,134 (60.0%) were female. Female survivors had a higher prevalence of vulnerability (47.8% vs 35.7%), and GS (65.5% vs 44.6%) than male s...


The essence of the intellectual property is a kind of monopoly right and the system itself exists a certain defects due to the monopoly.At present,three strands of anti-intellectual property trends have appeared in the international world and the focus of the controversy is the game of the process of the "positive and negative social effects" caused by the intellectual property rights;the reason of its controversial is that the modern intellectual property system has been transferred from the logical structure of "the modem intellectual property system,knowledge and morality" into "knowledge and efficiency",and its essence is the "game of rights and utility".


A speech recognition method comprises generating a voice prompt, receiving a spoken utterance by a user in response to the voice prompt, the spoken utterance comprising a speech artifact, and compensating for the speech artifact. Compensating for the speech artifact may comprise, for example, using a recognition grammar comprising the speech artifact as a voice component, or changing the spoken utterance in order to eliminate the speech artifact.


The interest of realizing cryogenic treatment on various materials has been increased recently. The dimensional stability of Shallow Cryogenic Treated (SCT) and Deep Cryogenic Treated (DCT) AISI 440C bearing steel compassion with Conventionally Heat Treated (CHT) have been investigated in this paper. Thermo mechanical analysis is carried out using a dilatometer. The temperature of the CHT, SCT and DCT specimens were increased upto 810 oC (1083k) with a constant rate of 5oC/min from atmospheric temperature. By using Linear Variable Differential Transformer (LVDT) the change in length of the specimens during the experiment is measured. By using these data, Coefficient of Linear Thermal Expansion (α) has been found for all the specimens, and DCT specimen has 8.7% lower than SCT and 14% lower than CHT specimen.


INTRODUCTION
We present our experience in endoscopic laser assisted dacryocystorhinostomy (DCR) analyzing the results obtained with a new technique that involves placing bicanalicolar silicone stent more Teflon tube, in combination with paraseptal silastic sheet.

MATERIALS AND METHODS
In our study 49 of 57 patients (85%) at a mean follow up of at least 12 months have not reported epiphora or more episodes of acute dacryocystitis.

RESULTS
49 out of the 57 patients (85%) in our group reported no additional epiphora or episodes of acute dacryocystitis.

CONCLUSIONS
Endoscopic DCR is currently the gold standard for sac and post-sac stenosis given the minimal invasiveness of the procedure and the long-term results that appear comparable to those obtained with extrinsic DCR. The principal problem is cicatricial stenosis that can occlude the stoma over time.


This paper presents an analytical model for the structural analysis of orthotropic rotor retention sleeves of High-Speed Surface mounted Permanent Magnet Synchronous Machines (SPMSMs). The solutions herein derived generalize existing analytical models for non-axisymmetric geometries, considering orthotropic materials (e.g. Fiber Reinforced Polymers). These rotor geometries arise when pole gaps are present, i.e. magnetically inert regions between rotor poles. This design feature allows magnet material savings, reduction in eddy current losses and overall mass minimization during the machine optimization. The results were validated using Finite Element Analysis (FEA). The analytical model described is approximately 400 times faster to compute than FEA. This is particularly advantageous for machine design optimization using evolutionary algorithms, which require a large number of design evaluations.


ABSTRACT Following the June 1967 Six-Day War, the Soviet Union and Britain invested significant efforts in rehabilitating their relations with the Arab countries, notably Egypt. While both supported the withdrawal of Israel from the Arab-occupied territories, the two countries differed over the nature of the settlement. Still, at the UN Security Council, the Soviet Union supported the British draft resolution for solving the Middle East conflict. Cold War interests and competition over influence in the Middle East, however, led the Soviets to launch a public campaign against British policy in the Middle East and prevented the two countries from joining efforts to bring about a breakthrough in the Arab–Israeli conflict.


3006 Background: To evaluate the safety and tolerability of vaccination with DCs loaded with killed tumor cells, 18 patients with measurable relapse/refractory follicular (12) and lymphoplasmocytoi...


The purpose of this article is to highlight the key ideas that are embodied in the TRANSYT and SCOOT methods of coordinating signals. It will explain how the SCOOT system of traffic-responsive control evolved from TRANSYT and conclude by reviewing some of the future directions of TRRL research.


This paper presents the initial results in laser electron acceleration from the newly commissioned E163 program at SLAC and an outline of the initial wave of experiments. These results include an inverse free electron laser (IFEL) interaction with 800 nm light from a Ti: sapphire laser which will be used along with a chicane to produce optically spaced electron microbunches. The microbunching is independently diagnosed via coherent optical transition radiation (COTR) at the second harmonic (400 nm) in order to avoid large background at the fundamental due to the laser. We will also discuss experiments that take the microbunch train formed by the IFEL/chicane and perform net acceleration using a second stage: an inverse transition radiation accelerator (ITR). This discussion includes the experiment layout and hardware as well as simulation of expected results.


INTRODUCTION Endometrial carcinoma is one of the common malignancies in female genital tract worldwide [1].Histopathological examination of endometrial tissue remains standard diagnostic procedure for uterine abnormalities, against which the performances of all new diagnostic tools for evaluating the endometrium are compared. The primary indication is in the diagnostic work up of women with abnormal uterine bleeding.


A series of KDP crystals were grown by traditional growth method at different rotation speeds.Meanwhile,according to the actual growth conditions in the crystallization chamber,a three-dimensional model was developed.The dependence of temperature and velocity distributions on rotation speeds and the crystal size was numerical simulated by the finite volume method.It revealed that the flow velocities of the solution along the surface of KDP fastened as the rotation speeds increasing,which leaded to an increase in the crystal growth rate and the quantities of impurities reduced.Compared with low rotation speeds(9.0-40 r / min),high rotation speeds(55 r / min and 77 r / min) were to the benefit for the growth of KDP crystal.


With the encouragement of national policies and the improvement of the public's awareness of environmental protection, the number of electric vehicles in our country has increased significantly. It is necessary to reasonably add new charging stations. This paper uses machine learning methods to remove private charging pile data from the original vehicle driving data and combine the characteristics of the charging points to obtain the location of the charging demand point, and then use hierarchical clustering algorithm to select the location of the new charging station and use the machine learning model to provide a reference for the capacity selection of each new charging station. Using the data of 1,000 vehicles operating in Zhengzhou as a case analysis, the results show that the charging demand satisfaction rate has increased from 62.27% to 80.8%, and the average distance between the new charging stations and the poi is as low as 143m. The results show that the method proposed in this paper can meet the needs of as many electric vehicle owners as possible while having better charging convenience.


A 7.5 cm, dual etalon Fabry-Perot spectrometer called DEFPOS has been set up at Coude focus of 150 cm RTT150 telescope at TUBITAK National Observatory (TUG, Antalya, Turkey) to investigate the physical properties of Diffuse Ionized Gas (DIG) in our Galaxy. The spectrometer, having a 4 arcmin circular field of view over a 200 km s–1 (4.4 A) spectral window near Hα, has been used to observe H II regions and Planetary Nebulae (PNe) since May 2007 (Sahan et al. 2009). Early observations have been analyzed and physical and kinematic properties such as the intensity, the line width, and the LSR velocity are presented here. These values are compared with earlier results from different studies. In this study, I discuss some results obtained by DEFPOS, including two H II regions (Sh2-156, Sh2-157), and two PNe (NGC 1360, and NGC 6826). The Intensities, the radial velocities and the line widths of the Hα emission line vary from 101.4R to 149.97R (1 Rayleigh =106/4π photons cm–2 sr–1 s–1 = 2.41 × 10–7 erg cm–2 s–1 sr–1 at Hα), –41.19 km s–1 to +8.34 km s–1, and 39.55 km s–1 to 58.23 km s–1, respectively (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)


Suburbanisation as a factor in increasing life expectancy The range of various options for the development of the suburban territory in the area of agglomeration is extremely wide. It covers both traditional forms of inclusion of suburban space in the city's sphere of life, as well as new ways of interaction between the city and the suburbs. In this paper, we consider a specific form of spatial organisation — suburbia and its impact on the quality of life and, as a result, on the life expectancy of the population. The purpose of the article is to study the modem process of suburbanisation, as a phenomenon and its impact on increasing the life expectancy of the population, analyse the conceptual apparatus in the concept of lifestyle, and consider a complex of problematic issues of the urban environment that pose a risk to public health. We research the positive and negative effects of suburbanisation and identify the main factors influencing the suburbanisation process. To solve the problems, the following methods were used: analysis, synthesis, systematisation,


One of the questions being asked of International Finance Corporation (IFC) is how it can maximize its development results. To answer this question, the first step is to estimate the economic value added of IFC-financed projects, the net benefits that accrue to all stakeholders, such as customers, workers, suppliers, investors, etc. We estimate that the projects financed by IFC have not only returned the invested capital plus a risk free return, but generated additional value added of about 56 cents for every dollar of project costs. IFC always works together with other financiers, and in the past has been able to support projects worth about $17.5 for every dollar of IFC capital, which in turn have generated an estimated $10 in value added. Significant value was added through these projects in all regions and industries, but particularly in infrastructure (including telecommunications).


Free radicals are atoms or molecules containing one or more unpaired electrons, making them very "reactive" (Surai, 2003). Biologically relevant free radicals are activated atoms or groups of atoms (usually containing oxygen or nitrogen) with an odd (unpaired) number of electrons. In a non-radical compound, all orbits are occupied by two electrons. When a chemical reaction breaks the bonds that hold paired electrons together, free radicals are produced. Therefore in a 'free radical' compound, there is a single unpaired electron in the outer orbit.


Background: HG is an on-target AE of PI3K inhibition, reported in 63.7% (36.6% G≥3) of HR[+]/HER2[-] ABC patients (pts) treated with ALP plus fulvestrant in SOLAR-1. HG was the most frequent adverse event (AE) leading to ALP discontinuation (6.3%). MET reduces systemic insulin resistance and suppress PI3K and Ras signaling. METALLICA is assessing the prophylactic use of MET for prevention of ALP-induced G3-4 HG in PIK3CA-mutated, HR[+]/HER2[-] ABC pts with normal fasting glycemia or prediabetic criteria. Methods: This is an open-label, single-arm, two-cohort, phase 2 trial. Pts aged ≥18 years, ECOG PS of 0–1, and PIK3CA-mutated, HR[+]/HER2[-] ABC, progressing to an aromatase inhibitor (AI)-containing regimen, ≤2 previous endocrine therapy (ET) and ≤1 prior chemotherapy regimens for ABC were eligible. Pts were enrolled into cohorts according to glycemia at baseline: (A) pts with normal fasting glycemia < 100 mg/dL and glycosylated hemoglobin (HbA1c) < 5.7%; (B) pts with prediabetic fasting glycaemia 100–140 mg/dL and/or HbA1c 5.7–6.4%. Pts received oral ALP 300 mg/day, starting from C1D8, in combination with ET; fulvestrant, letrozole, or exemestane as per standard of care; and oral MET 1000 mg/day on days 1-3 and 2000 mg/day thereafter. The primary endpoint was G3-4 HG incidence as per NCI-CTCAE v.4.03 at 2 first cycles of treatment. Assessment of glycemia was performed by rigorous self-monitoring blood glucose and local laboratory confirmation in fasting conditions. Secondary endpoints included objective response (ORR), clinical benefit rate (CBR), duration of response (DoR), progression-free survival (PFS), and safety. Sample size was based on a Simon's two-stage design in cohorts A (H0: G3-4 HG ≥25%; H1: G3-4 HG ≤10%) and B (H0: G3-4 HG ≥40%; H1: G3-4 HG ≤15%). We planned to attain 80% power at the nominal one-sided α level of 0.05 for each cohort. Results: Between Aug 30, 2020, and Mar 10, 2022, 68 pts were enrolled at 18 sites (48 cohort A, 20 cohort B). Median age was 55 (range, 29–79) years and 58.8% pts had visceral disease and an ECOG PS 0. A total of 66 (97.1%) pts had been previously treated with a CDK4/6i and 13 (19.2%) pts had received chemotherapy for advanced disease. Sixty-three (92.6%) pts received fulvestrant as ET (45 cohort A, 18 cohort B). With a median follow-up of 8 (range, 1.6–14.9) months, 28 (41.2%) pts remain on study treatment. Disease progression was the main reason for discontinuation, reported in 32 (47.1%) pts. The primary endpoint of the study was reached, with 1 (2.1%) pts (95%CI, 0.8–9.5; p < 0.001) in cohort A and 3 (15%) pts (95%CI, 4.5–33; p = 0.012) in cohort B experiencing a G3-4 HG episode over the 2 first cycles of treatment. For patients on fulvestrant, G3-4 HG rates were 1 pts (2.2%) and 3 (16.7%) pts for cohorts A and B, respectively. No ALP discontinuation related to HG was reported during the first 2 treatment cycles. Median PFS in all patients was 7.4 months (95%CI, 6–NA). Among pts with measurable disease, ORR was 14 (36.8%) pts (95%CI, 21.8–54). At the time of this analysis, DoR and CBR were still immature. The most common AEs were diarrhea (67.6%; 13.2% G≥3), nausea (67.6%; 0% G≥3), and fatigue (45.6%; 2.9% G≥3). Serious AEs occurred in 15 (22.1%) pts. The main serious AEs were rash (2.9% G≥3) and vomiting (1.5% G≥3). No additional pts reported G≥3 HG after the first 2 cycles. The dose of ALP was reduced according to the protocol in 19 (27.9%) pts. Eight (11.8%) pts permanently discontinued ALP due to AEs, none of whom related to HG. No treatment-related deaths were reported. Conclusions: Prophylactic use of MET substantially reduced the incidence and severity of ALP-related HG with no additional toxicities and could be a new standard for PIK3CA-mutated, HR[+]/HER2[-] ABC pts receiving ALP plus fulvestrant or other ET.
 Citation Format: Manuel Ruiz Borrego, Pablo Tolosa, Salvador Blanch, Adela Fernández, Ander Urriticoechea, Isabel Blancas, Cristina Saura, Beatriz Rojas, Begoña Bermejo, Jose Ponce, Maria Gión, Elisenda Llabres, Elena Galve, Juan Fernando Cueva, Ana López, José L Alonso-Romero, Santiago González-Santiago, Eduardo Martínez De Dueñas, Fernando Gomez Peralta, Eva Ciruelos, José Manuel Pérez-García, Antonio Llombart-Cussac, Javier Cortés. Metformin (MET) for the prevention of Alpelisib (ALP)-related Hyperglycemia (HG) in PIK3CA-mutated, Hormone Receptor-Positive (HR[+]) HER2-Negative (HER2[-]) Advanced Breast Cancer (ABC): The METALLICA study. [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr PD8-02.


Synthetic dyes are usually carcinogenic, therefore it is necessary to use alternative dyes to reduce the use of synthetic dyes, namely by using natural dyes. This study aims at determining the potential of Laban leaves as a natural dye in silk fabrics. Extraction was done by boiling the leaves for 1 hour. The dyeing of the mordanted cloth was done 4 times. The dyed fabrics were treated with post mordanting using alum, calcium oxide and tunjung with a concentration of 50gr/l. Fabric testing was carried out by testing the color strength and color fastness to washing with soap. The results of the color strenght test showed that the highest value was obtained by the use of tunjung with a T% value of 88.96 for very dark criteria, then followed by calcium oxide mordant with a value of 30.20 and the lowest value on the use of alum mordant with a value of 20.97 for light criteria. The color fastness test to washing generated an average value of 4 which was in the good category.


The direct mechanochemical amidation of esters - enabled by ball-milling - is herein described. The operationally simple procedure requires inputs of ester, amine, and sub-stoichiometric KOtBu and is applicable to a preparation of a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of API's, agrochemicals, and its ability to deliver gram-scale synthesis of active pharmaceuticals and building blocks is demonstrated, all in the absence of a reaction solvent.


An ongoing case study of the history of resident activism in Wentworth Gardens, a Chicago public housing development, illustrates the ways in which over three decades of invisible community building work have prepared women residents for visible political action in a high stakes public battle over the proposed siting of a new sports stadium. The study elaborates upon the neighborhood participation literature by assessing the contribution of residents' past collective actions to change housing conditions and their modest victories to better understand residents' present grassroots participatory efforts. It explicates the ways in which past efforts provided a rich environment for nurturing individual residents, local leadership, and resident empowerment. These observations of Wentworth women's activism share many commonalities with research from other grassroots community activism among poor and working class women, particularly of color. Poor women of color gain their power from individual dedication and perSistence, and from their social relations that are embedded in the communities in which they live. Furthermore, the skills they bring to collective actions are cultivated through everyday routine activities of maintaining households and communities - tasks necessary to the "social reproduction" of individual households as well as social arrangements they make to protect, enhance and preserve the cultural experiences of all members of the community.