In this study, we document that the overall rate of protein synthesis decreases during in vitro maturation (IVM) of pig oocytes despite enhanced formation of the 5′ cap structure eIF4F. Within somatic/interphase cells, formation of the eIF4F protein complex correlates very well with overall rates of protein translation, and the formation of this complex is controlled primarily by the availability of the 5′ cap binding protein eIF4E. We show that the eIF4E inhibitory protein, 4E‐BP1, becomes phosphorylated during IVM, which results in gradual release of eIF4E from 4E‐BP1, as documented by immunoprecipitation analyses. Isoelectric focusing and Western blotting experiments show conclusively that eIF4E becomes gradually phosphorylated with a maximum at metaphase II (M II). The activity of eIF4E and its ability to bind mRNA also increases during oocyte maturation as documented in experiments with m7‐methyl GTP‐Sepharose, which mimics the cap structure of mRNA. Complementary analysis of flow‐through fraction for 4E‐BP1, and eIF4G proteins additionally provides evidence for enhanced formation of cap‐binding protein complex eIF4F. Altogether, our results bring new insights to the regulation of translation initiation during meiotic division, and more specifically clarify that 4E‐BP1 hyper‐phosphorylation is not the cause of the observed suppression of overall translation rates. Mol. Reprod. Dev. © 2005 Wiley‐Liss, Inc.


Software quality is a very important aspect in evolving strategy for IT vendors involved in commercial off-the-shelf (COTS) (also referred as packaged software) product development. Software metrics are widely accepted measures for monitoring and managing the quality in software projects. Enterprise resource planning (ERP) systems are COTS products and attempt to integrate data and processes in organizations and often require extensive customization. Using software quality metrics already established in literature, software quality attributes defined by the quality model ISO/IEC 9126 were evaluated for a standard and a customized ERP product. This will help the ERP team to identify the specific quality attributes that were affected owing to customization. This research study infers that there exists a considerable impact of ERP system customization over the quality of ERP product. The implications of the findings for both practice and research are discussed, and possible areas of future research are identified.


"TRY him on a little emetine!" This sage advice was often given by our elders with regard ,to obscure fevers and other mysterious disease phenomena which haq: r~sisted many forms of treatment. It was good advice. My impression i~ that it is now less frequently acted upon than formerly. Perhaps we are too engrossed with the types and strains of the great bacillary group Qfdysenteries to dwell long upon the activities of that simple creature; the Entanueba histolytica. The subacute and chronic forms of amoobiasis are known to be difficult to recognize. Among other obstacles, the following; either singly or in combination, are found:, Ca) The previous medical history is often negative or misleading. : (b) An insidious onset of symptoms and signs. (c) U uusual manifestations; (d) Amd:lbiasis may occur in the course of another disease. (e) Negative laboratory findings.


Endoscopic surgery demands different specific psychomotor skills than open surgery.
Virtual reality simulation training has the potential to be a valuable tool in training these skills, because simulation provides the opportunity to train psychomotor skills in a safe environment. In addition to training, virtual reality simulators are capable to objectively assess the skills of a subject in training. In contrast to traditional box trainers and animal models that require human monitored evaluation resulting in subjective assessment. The LapSim virtual reality simulator is a system designed to develop and assess basic psychomotor skills and advanced laparoscopic tasks in a virtual environment. Prior to implementation of these simulation based training modalities into the surgical training curriculum the simulator has to be validated. The training programs should be developed and evaluated.


PURPOSE
An optimal sequence algorithm model of divided period appointment consultation service was built through optimal sequence algorithm.

METHODS
Re-visiting patients in the department of stomatology in a tertiary hospital were enrolled as the research objects in this study. Information about the diagnose term of common diseases, tooth positions treated, doctor's consultation hours were collected. After calculating the mean consultation hours of each disease based on the statistical analysis, the appointment consultation service sequence of re-visiting patients in the department of stomatology was optimized in accordance with the rule of "providing priority service to those requiring short consultation hours" by referencing to the theoretical model of parallel machine.

RESULTS
The total waiting hours of patients after optimizing the appointment consultation sequence was decreased by 35.1%.

CONCLUSIONS
Optimal sequence algorithm can optimize divided period consultation sequence, effectively shorten waiting hours and improve patients' medical experience.


The separation of human serum globulins into individual components was investigated by capillary zone electrophoresis (CZE) using a linear polyacrylamide‐coated capillary at pH 7.4. Prior to CZE analysis of globulin components present in serum, it was found that it was necessary to remove albumin. Preparation of albumin‐depleted human serum with a HiTrap Blue column allowed the detection of α‐ and β‐globulin components as a series of peaks. Almost all the peaks, both narrow and broad, observed in CZE analysis could be assigned to six globulin components (α1‐acid‐glycoprotein, α1‐antitrypsin, haptoglobin, α2‐macroglobulin, Gc‐globulin, and transferrin) by using the technique of antibody‐based indirect detection. The CZE results, obtained from serum preparations from three healthy adults and six patients, showed that the CZE system might be capable of detecting qualitative differences among individuals with regard to individual globulin components.


This paper portrays the ethical challenges facing South Africans in the post-apartheid era. I argue that The Confession of Belhar 1986 (hereafter referred to as Belhar) plays an illuminating role in describing these challenges as well as in suggesting ways in which South African churches can respond to them. The paper is structured as follows. In a first round the origins of Belhar is sketched (a). Thereafter (b) the significance of the five articles of Belhar (1-5) for identifying, describing and showing ways to address the ethical challenges facing South African churches is indicated. Opposition to deism, agnosticism, disunity, alienation, injustice and wrong loyalties is strongly pleaded for. The paper concludes (c) with general remarks about the significance of Belhar for the ethical task of South African churches, especially Reformed churches.


The mathematical formula of HIV/AIDS is governed by the ordinary differential equation with seven variables. S and E are susceptible/un-educated and educated individuals respectively, I1 and I2 are HIV-positive individuals consuming and not consuming ARV respectively; A and T are AIDS individuals not and receiving treatment; and R is a recovered individual. We study multi-interaction between infected and educated subpopulations. We analyze the local stability of the equilibrium points. The results are the disease-free is asymptotically stable when satisfying R0 < 1 and the endemic equilibrium point is asymptotically stable when satisfying R0 > 1. The numerical solution supports the analytical results.


An antifungal compound which conforms to Muller's definition of a phyto· alexin has been isolated from the endocarp tissues of detached pea pods inoculated with Monilinia jructicola. The same compound has been identified in inoculated organs of growing pea plants. This compound, which is an abnormal metabolite of pea tissues, has been named "pisatin".


With its focus on peer-reviewed analyses of data gained from marking birds, Ringing & Migration occupies a unique niche as an international ornithological journal. Whether driven by passion and curiosity or advancing the aims of conservation, a significant proportion of the data and effort that goes into many Ringing & Migration papers is funded only in part by public resources and relies heavily on the input of time, money and expertise of volunteer ornithologists at all levels. Across the landscape of science publishing, the standard of peer-reviewed papers has been transformed by the availability of computers for word processing, graphics and statistical analysis. Ringing & Migration, since its inception in 1975, has seen a similar increase in scientific and editorial standards and this will continue as we strive to publish the best ornithological research within the journal's niche. Ornithologists, whether publicly-funded or not, naturally want to promote the results of their work to their peers, and publishing in a journal with a wide readership is important. Ringing & Migration, unlike many leading ornithological journals, has the potential to achieve that by being freely available online. The perceived prestige of a journal is also important; this is hard to define but one approach is to count the number of citations (references by other authors to papers published in a journal), relative to the total number of papers published by the journal over a specified period, giving an 'Impact Factor'. For many years, Thomson Reuter (previously under the name Institute for Scientific Information or ISI) have produced annual listings of Impact Factors for a range of journals (Garfield 2010). The dominance of the Thomson Reuter Impact Factors is such that many people and institutions use these as a measure of the worth of published papers. As a consequence, work published in journals with no Impact Factor can be regarded as of low value. The problem for Ringing & Migration is that, despite its status as a peer-reviewed ornithological journal (but possibly because of its specialised niche), it does not appear in Thomson Reuters citation indexes and does not have an 'official' Impact Factor. The 'Catch-22' is that we need to increase the citation rate of papers in Ringing & Migration to increase the perceived value of our science and achieve an Impact Factor, but authors may be discouraged from submitting their work to the journal because Ringing & Migration does not have such an Impact Factor. As a metric to judge research quality, the number of citations alone is not a reliable measure: research of high quality may receive few citations and vice versa (Anon 2010). Even mainstream science journals complain about the dominance of Impact Factors as a measure of worth (Hascall & Hanson 2010). Within ornithological journals, the specialised niche of Ringing & Migration also puts it at a disadvantage in the Impact Factor stakes. However, there is light at the end of the tunnel. An alternative method in which citations are weighted by the quality or status of the citing journal (Bollen et al 2006, González-Pereiraa et al 2009) is the basis of the SCImago Journal and Country Rank (SJR) Indicator used to rank the extensive range of journals in the Elsevier Scopus database. As a moreconsidered measure of journal prestige, the SJR Indicator may well replace the Thomson Reuter Impact Factor for assessing journal status in the future (Bollen et al 2006). Using SJR Indicators for 2009 (www.scopus.com/source/ eval.url), when ranked against the 18 ornithological journals in the Thomson Reuters Journal Citation Reports (2008 Impact Factors), Ringing & Migration comes 7 behind (in order) Journal of Avian Biology, Ibis, Journal of Ornithology, Auk, Condor and Ardea. Whether the current SJR ranking of Ringing & Migration, an increase on previous years, can be sustained is uncertain, but there is now huge potential for new technologies in combination with bird marking and new analysis tools to advance our understanding of bird biology. Ringing & Migration is the place to publish.


Employee involvement of 100% in a total quality management initiative has made improvements in a Swedish hospital's ENT-department. Improvement was driven by needs for good health care and for cost reductions in a region with a lagging economy. The de..


Electrodialysis is an efficient process for the cleaning of industrial water effluent streams from toxic ionic substances with the simultaneous recovery of valuable ions for reuse. Energy consumption and waste recovery are the two key goals of the process. A dynamic optimisation program aims to determine the optimal operating conditions in terms of applied voltage and effluent flow rate in a batch operating scheme. A model is developed that accounts for the ion transfer through the ion selective membranes and the dynamics of the system. A combination of three objective functions targeting the minimisation of the overall batch process time, the minimisation of the electrical energy consumption required for the ion transfer, and the maximisation of the overall degree of separation is investigated. The manipulated variables applied voltage and feed stream flow rate are considered as piecewise constant during each time interval, spanning the duration of the entire batch. The dynamic optimisation problem is solved through standard non-linear programming techniques which calculate the optimal batch duration and condition profiles for the system. A multi-objective analysis is presented for various combinations of weight values for the joint objective function through the development of the Pareto optimal front. The current approach has been implemented in the removal and recovery of sulfuric anions from an aqueous solution and resulted in the achievement of a high degree of separation in a shorter period at a much lower energy consumption.


The deficiency of P and the shortened growing season s due to climate change are identified constraints in the production of commonly grown long maturing maize hybrid (H614) in the acid soils of Molo County , Kenya. The current studytherefore investigated(i) the effect of soil amendments; lime (L), minjingu phosphate rock (MPR) and manure (FYM) on soil available P and its uptake, phosphorus use efficiency (PUE) and maize grain yield of long (H614) and short (H513) maturing maize hybrids and (ii) the relative agronomic efficiency (RAE) of MPR. Field experiments were set up at the


We use collective oscillations of a two-component Bose-Einstein condensate (2CBEC) of \Rb atoms prepared in the internal states $\ket{1}\equiv\ket{F=1, m_F=-1}$ and $\ket{2}\equiv\ket{F=2, m_F=1}$ for the precision measurement of the interspecies scattering length $a_{12}$ with a relative uncertainty of $1.6\times 10^{-4}$. We show that in a cigar-shaped trap the three-dimensional (3D) dynamics of a component with a small relative population can be conveniently described by a one-dimensional (1D) Schr\"{o}dinger equation for an effective harmonic oscillator. The frequency of the collective oscillations is defined by the axial trap frequency and the ratio $a_{12}/a_{11}$, where $a_{11}$ is the intra-species scattering length of a highly populated component 1, and is largely decoupled from the scattering length $a_{22}$, the total atom number and loss terms. By fitting numerical simulations of the coupled Gross-Pitaevskii equations to the recorded temporal evolution of the axial width we obtain the value $a_{12}=98.006(16)\,a_0$, where $a_0$ is the Bohr radius. Our reported value is in a reasonable agreement with the theoretical prediction $a_{12}=98.13(10)\,a_0$ but deviates significantly from the previously measured value $a_{12}=97.66\,a_0$ \cite{Mertes07} which is commonly used in the characterisation of spin dynamics in degenerate \Rb atoms. Using Ramsey interferometry of the 2CBEC we measure the scattering length $a_{22}=95.44(7)\,a_0$ which also deviates from the previously reported value $a_{22}=95.0\,a_0$ \cite{Mertes07}. We characterise two-body losses for the component 2 and obtain the loss coefficients ${\gamma_{12}=1.51(18)\times10^{-14} \textrm{cm}^3/\textrm{s}}$ and ${\gamma_{22}=8.1(3)\times10^{-14} \textrm{cm}^3/\textrm{s}}$.


Methods for the simultaneous analysis of the relationships of binary variables for efficacy and toxicity to dosage of an experimental drug are developed. Properties of two models of 'within-dose' dependence of efficacy and toxicity in parallel designs - one a bivariate analogue of the familiar univariate logistic model, and the other an adaptation of a general model developed by D.R. Cox– are explored. The cell probabilities predicted by these models are often quite similar to those predicted by a model of independence of efficacy and toxicity, but large discrepancies can occur when there is approximate equality of the median effective and median toxic doses. Asymptotic variances of estimates of parameters involved in assessing correlation are large when there is little or no dependence in the data, but parameters can be estimated with good precision in at least some cases of moderate to strong dependence between efficacy and toxicity.


This paper describes a performance and comparison of different methodologies for the design of low power CMOS phase frequency detector for high speed applications like PLL. The phase frequency detector (PFD), which helps PLLs achieve simultaneous phase and frequency error detection, is an indispensable functional block and plays an important role in improving the performance of the whole PLL system. This paper also discusses two major problems in PFD, namely, the dead zone problem and the missing edge problem. The proposed design will be the CMOS phase frequency detector for high speed applications with low power dissipation. The PFD will be implemented using 0.18 μm technology. The designed phase frequency detector can be used in PLL with frequency up to 1 GHz.


Abstract
 Allelopathy is one explanation for non-native plant invasion, but native plants also can be allelopathic. We tested the allelopathic potentials of the non-native, invasive grass Microstegium vimineum (Japanese Stilt-grass) and the native herb Ageratina altissima (White Snakeroot), which both can dominate the herb layer in central New Jersey forests. Aqueous extracts from roots and shoots of both species negatively affected the speed of germination and the percent germination of Lettuce and Radish seeds in Petri dishes, and White Snakeroot shoot extract had the strongest effect. In a factorial experiment in pots of forest soil that combined extract treatments with activated carbon addition (to manipulate allelochemicals) and soil sterilization (to investigate indirect allelopathic effects via the soil microflora), Lettuce and Radish seedling establishment was reduced by extracts, especially from the native White Snakeroot. However, growth of surviving seedlings was unaffected by the extracts or their interactions with carbon or soil sterilization. These results show that a native species had stronger allelopathic potential than an aggressive, non-native invader from the same forest and that allelopathy was effective on the earliest developmental stages of the target plant species. In addition, activated carbon and sterilization interacted to directly influence plant growth. Growth was greater in sterilized than unsterilized soils, but only when carbon was added, suggesting caution in using these techniques in allelopathy studies.


Graphene oxide (GO) has received considerable attention in real-time glucose detection due to its high surface area, excellent electrical conductivity and good biocompatibility. However, the reactive sites of GO increases background current of biosensors, which makes a current offset and limits the sensitivity. In this work, functional graphene (FG) and electrochemically reduced graphene oxide (RGO) was laminated on the surface of glass carbon electrodes, then the glucose oxidase (GOD) was absorbed on the graphene lamination layers, and thereafter chitosan (CS) was casted onto the obtained electrodes. This FG-RGO-GOD-CS electrode shows faster heterogeneous electron transfer rate (3.557 s −1 ) and much higher enzyme loading (3.80 × 10 −9 mol/cm 2 ) as compared with other graphene oxide-based biosensors. As shows in figure 1, the cathodic current decreases linearly with the increase of glucose concentration, and the sensitivity is calculated to be 72.29 μA mM −1 cm −2 . With the advantage of facile fabrication, high conductivity and high enzyme loading, the FG-RGO lamination structure may be a good candidate in the production of cost-effective biosensors and biofuel cells. scan rate ranging from 25 to 300 mV s -1 . The redox processes of the GOD– RFG-RGO–CS nanocomposite gave roughly symmetric anodic and cathodic peaks at relatively slow scan rates. When the scan rate increases, the redox potentials of GOD shift slightly. This RFG-RGO-GOD-CS electrode shows faster heterogeneous electron transfer rate (3.557 s −1 ) and much higher enzyme loading (3.80 × 10 −9 mol/cm 2 ) as compared with other graphene oxide-based biosensors.


The analysis of strategies adopted in the last 10-15 years by companies in emerging countries that have managed to reach the status of global companies, enables us to appreciate that, in a first stage, emerging companies have followed the "normal" principles of corporate strategies that have lead Western companies to a multinational or a transnational status. But more important is what happened in the second stage, namely that many emerging companies were able to overcome the classical principles and strategies and to develop new business models, such as the integration of "functions" resulted from the global value chain restructuring, based on the new "functional" specialization in manufacturing and services, the building up of global networks of suppliers or the reverse outsourcing. However, the range of strategies implemented by emerging companies in their efforts to become global players comprise also "classical" strategies such as the global brand development, the global development and supply of niche products, the non-organic growth or the strategy of geographical adjustment of business flows on South-South and South-North directions.


Differentiating the syndrome of a disease according to the symptoms is the basic pattern of traditional Chinese medical(TCM) syndrome-differentiating system,with the advantage and feature of flexibility,and the disadvantage of being difficult to be regulated and unified.Based on determining the pathogenesis according to syndrome differentiation,this paper has presented the conception of pathogenic syndrome element which is the pathogenic element of a syndrome in a certain disease range,with the function of generalizing/reflecting the pathogenic characteristics of the syndrome.Springing from the pathogenic elements,the pathogenic syndrome elements have a limited number and clear content,so it's completely feasible to set up their regular syndrome-differentiating diagnostic standard,of which the premise is making a diagnostic scale of pathogenic syndrome element.Taking hemorrhagic stroke for example,this paper has studied the method and procedure of making the pathogenic syndrome element diagnostic scale,and has further studied the syndrome-differentiating diagnostic method based on the combination of pathogenic syndrome elements.The results have reflected the union of syndrome-differentiating flexibility and syndrome standardization,so as to adapt to the complicated and changeable situation of TCM clinical syndromes,and open up a new way of establishing the TCM differential model with the union of syndrome standardization and syndrome-differentiating flexibility.


Background: When researchers' careers are disrupted by life events – such as illness or childbirth – they often need to take extended time off. This creates a gap in their research output that can reduce their chances of winning funding. In Australia, applicants can disclose their career disruptions and peer reviewers are instructed to make appropriate adjustments. However, it is not clear if and how applicants use career disruption sections or how reviewers adjust and if they do it consistently. Methods: To examine career disruption, we used surveys of the Australian health and medical research community. We used both a random sample of Australian authors on PubMed and a non-random convenience sample. Results: Respondents expressed concerns that sharing information on career disruption would harm their chances of being funded, with 13% saying they have medical or social circumstances but would not include it in their application, with concerns about appearing 'weak'. Women were more reluctant to include disruption. There was inconsistency in how disruption was adjusted for, with less time given for those with depression compared with caring responsibilities, and less time given for those who did not provide medical details of their disruption. Conclusions: The current system is likely not adequately adjusting for career disruption and this may help explain the ongoing funding gap for senior women in Australia. Funding: National Health and Medical Research Council Senior Research Fellowship (Barnett).


In connection with the problem of stability of servo-mechanisms, whose elements vary with time t, stability property of some ordinary differential equation is studied. Firstly, a linear ordinary differential equation, whose coefficients vary with time t, is considered. The variation with time t is regarded to be expressed by linear functions of ξ, where [function]. It is shown that the solution of the given linear differential equation, thus specified, can be expressed as power sesies with respect to ξ, by means of which, the question of stability may be examined. Secondly, it is pointed out that, the problem of similar kind, for the case of non-linear servo-mechanism, can be studied, by following the classical method of É. Picard. Abstract 1n connection with the problem of stability of servo-mechanisms , whose elements vary with time t , stability property of some ordinary differential equation is studied. Firstly , a linear ordinary differential equation , whose coe 缶 cientsvary with time t , is considered. The variation with time t is regarded to be expressed by linear functions of c , where ご =e at. (α< 0) . It is shown that the solution of the given 1i near di 百 erentialequation , thus speci 自 ed , can be expressed as power sesies with respect to t;, by means of which , the question of stab i1i ty may be examined. Secondly , it is pointed out that , the problem of similar kind , for the case of non-linear servo-mechanism , can be studied , by following the classical method of 立. Picard.


Light-cured flowable composites were introduced to the dental profession in 1995 with Revolution. The original manufacturer (E & D Dental Products) recommended that it could be used for Class III, IV, and V restorations, porcelain veneer cementation, porcelain and marginal defect repairs, sealants, and core buildups. Amazingly, one of the most popular contemporary uses of flowable composites, namely as the first increment at the bottom of the proximal box of a Class II preparation, was not even mentioned as an indication for Revolution.


The present dissertation deals with the factors which can lead a firm with a premium quality product to lose market shares. To go through this topic, the example of the French wine in Sweden is cho ...


SUMMARY This paper considers a model for the di⁄erence of two proportions in a paired or matched design of clinical trials, case-control studies and also sensitivity comparison studies of two laboratory tests. This model includes a parameter indicating both interpatient variability of response probabilities and their correlation. Under the proposed model, we derive a one-sided test for equivalence based upon the eƒcient score. Equivalence is defined here as not more than 100* per cent inferior. McNemar's test for significance is shown to be a special case of the proposed test. Further, a score-based confidence interval for the di⁄erence of two proportions is derived. One of the features of these methods is applicability to the 2]2 table with o⁄-diagonal zero cells; all the McNemar type tests and confidence intervals published so far cannot apply to such data. A Monte Carlo simulation study shows that the proposed test has empirical significance levels closer to the nominal a-level than the other tests recently proposed and further that the proposed confidence interval has better empirical coverage probability than those of the four published methods. ( 1998 John Wiley & Sons, Ltd.


Osteosarcoma is a deadly bone tumor. Our former study found that inhibiting autophosphorylation of HER2 could restrain the invasion and migration ability of osteosarcoma cells. As a pan-HER inhibitor, Neratinib, has completed preclinical phases and is currently undergoing various clinical trials. The objective of this study was to confirm the efficacy of Neratinib in the treatment of HER2 amplified osteosarcoma. Migration, invasion and proliferation abilities of OS cells were tested by wound healing, transwell invasion and CCK-8 assays. Results revealed that the migration, invasion and proliferation properties were declined in cells treated with Neratinib (P<0.05). Furthermore, in order to investigate the possible molecular mechanisms involved, western blot assay was used to determine the expression of p-HER2, phosphatidylinositol 3-kinase (PI3K), p-AKT and AKT proteins in OS cells. Results showed that the expression level of p-HER2, PI3K and p-AKT were decreased after treatment with Neratinib (P<0.05). Collectively our findings identified the tumor suppressive role of Neratinib in the development of malignant human osteosarcoma, and suggest its potential as a functional biomarker with predictive value in cancer predisposition, progression and treatment in clinic.


PCA refers to methods of pain relief that allow a patient to self-administer small doses of an analgesic agent as required. Most often, the term PCA refers to programmable infusion pumps that deliver opioid medications IV, although many other methods and routes of delivery using opioids as well as other analgesic agents have been described (SC, epidural, IT, SL, IN, oral, pulmonary, and TD). In addition to treating postoperative pain, PCA is used for pain following trauma and with cancer.


Model potential (MP) method is used in SCF and dispersion energy calculations of weak interactions in Ar2, Kr2 and Xe2 dimers. The calculated SCF interaction energies at van der Waals region are very close to the ones from the best available all-electron (AE) calculations. The performance of both Moller-Plesset (M-P) and Epstein-Nesbet (E-N) schemes of the dispersion energy calculation is studied. The SCF interaction energy augmented with the E-N dispersion energy agree quite well with experimental energies. |For the Xe2 dimer the relativistic effects are included on the level of Cowan and Griffin's Relativistic Hartree-Fock (RHF) method and their influence on the total interaction energy in the van der Waals region is found to be quite substantial.


An animated free-form deformation method is presented in this paper. The deformation is achieved by attaching the object to be deformed onto two parametric surfaces, which are called the shape surface and height surface respectively. In the proposed deformation method, the shape surface controls mainly the shape of the deformed objects while the height surface modifies the height of the objects. After the deformation is defined, animated deformation can be set up through thelocal coordinates of the deformed objects, the shape of the two parametric surfaces or even the combination of them. By this way, predefined shape animation can be realized. The experimental results show that the proposed method is intuitive, flexible and easily controlled.


In Plato's Apology of Socrates, Socrates claims that any just person who becomes involved in politics will be destroyed by the "multitude" and that the philosopher must therefore lead a private life. I argue that Socrates' elaboration of his relation to the political community, especially in the trial of the generals of Arginusae and the arrest of Leon, raises more questions than a cursory reading can answer both with respect to the logical structure of the argument in the Apology and in comparison with other Socratic formulations of the relation of philosophy and the city. Far from demonstrating the incompatibility of philosophy and politics, Socrates in the Apology and other dialogues limns the features of a conception of political life that incorporates philosophical principles of moderation and dialectical examination into an understanding of politics directed towards the moral and intellectual development of the citizens.


The COVID-19 pandemic caused a drastic decrease in all users of contraceptives, causing the birth rate (baby boom) to increase by 10% during the COVID-19 pandemic. Several factors have contributed to the increasing decline in contraceptive use, including the lack of health facilities with COVID-19 standardized personal protective equipment, causing concern for couples of childbearing age (EFA) thus delaying visits to health facilities to consult or use family planning, and a small number of health facilities in particular. Contraceptive services do not open a practice because they do not have the means to prevent the spread of COVID-19. This study aims to develop an android-based contraceptive consultation application in anticipation of the baby boom during the COVID-19 pandemic. This research on the development of an android-based contraceptive consultation application during the COVID-19 pandemic was developed to facilitate between family planning acceptors and health workers so that the family planning service program continues to run well. This type of research uses quantitative research with a research design using a combined method (combination method) between Research and Development (R&D) and Pre Experiment methods with One group Pre-test and Post-test designs which will be carried out in the working area of Tiumang Health Center, Tiumang District, Dharmasraya Regency, Province West Sumatra. The research instrument used is a questionnaire and informed consent which will be given to respondents at the time of pre-test and post-test with the tool used is an android-based contraceptive consultation application. The steps of this application design model include needs analysis, development design, contraceptive consultation application development, expert validation test, large-small group trial, and android-based contraceptive consulting application product. The results obtained in this study are an application designed and the features needed by EFA in collaboration with experts in the field of information technology (IT). The calculation of application observations carried out by design experts overall reached 84% meaning valid, while content observations / materials in applications carried out by content experts overall reached 80% meaning valid.


The efficiency of the purchasing and procurement logistics is important in automotive industry. The rationalization of production system is directly impact on productivity and quality. For this reason importance of logistics is high. Despite we are continuously making effort, our country are still b...


: Herewith, we report the design and synthesis of a series of the cyclocondensation of the substituted hydrazine derivatives with the substituted 1,3-dicarbonyl compound is a simple and rapid approach to obtain substituted pyrazoles ( 3a-h ). This compound was obtained by using catalyst and water as solvent under microwave irradiation for about 2 – 4 min (800 W) at 80 °C, to get structural prerequisite indispensable for anticancer activity. The reaction was perform in mild reaction condition, good to excellent yields, easy workup and easily available starting material make the reaction attractive for the preparation of compounds 3a-h


A series of 2-oxo-2,5-dihydro-1H-chromeno[4,3-b]pyridine derivatives were obtained by using a one-pot three component reaction of 2,2-disubstituted chroman-4-one with aromatic aldehydes and 2-cyanoacetamide in the presence of sodium hydroxide under solvent-free conditions. Heating chromenopyridine derivatives with phosphoryl chloride gave the corresponding chloro derivatives. The reaction of the chloro derivatives with hydrazine hydrate afforded dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridines derivatives. Condensation of the dimethyl derivative compound with the aromatic aldehydes gave 8-Arylideneamino-6,6-dimethyl-10H-chromeno[4,3-b]pyrazolo[4,3-e]pyridine.


De-Colonizer is an alternative research center on Palestine/Israel, aiming to bring to a wide audience new academic-level knowledges and tools. Its aim is to propose, based on concrete examples, a reading of socio-political realities that differs from the official Israeli narrative. The team thus produced the map Colonialism in destru(a)ction which shows all the destroyed localities in Palestine and Israel since the beginning of zionist migration (end of 19th century). It has also (...)


(57) The invention relates to the selection of an antenna in a receiver of a mobile radio station which forms part of a time-multiplexed radio communication system. The signal strength of each antenna is measured in each time slot which immediately precedes the time slot intended for the station concerned, and the antenna selection is effected in dependence on the measured signal strengths. In order to eliminate the risk of unsuitable antenna selection as a result of momentary falls in signal strength, the signal strength for each antenna is measured on several occasions during the time slot in which the measurements take place. The signal-strength values for each antenna are thereafter combined linearly, so as to form a suitability measurement. The antenna having the highest suitability measurement is selected for the next arriving time slot.


Primary hypertrophic osteoarthropathy (PHO) is a rare familial disorder with reduced penetrance for females. The genetic mutations associated with PHO have been identified in HPGD and SLCO2A1, which involved in prostaglandin E2 metabolism. Here, we report 5 PHO patients from four non-consanguineous families. Two heterozygous mutations in solute carrier organic anion transporter family member 2A1 (SLCO2A1) were identified in two brothers by whole-exome sequencing. Three heterozygous mutations and one homozygous mutation were identified in other three PHO families by Sanger sequencing. However, there was no mutation in HPGD. These findings confirmed that homozygous or compound heterozygous mutations of SLCO2A1 were the pathogenic cause of PHO. A female individual shared the same mutations in SLCO2A1 with her PHO brother but did not have any typical PHO symptoms. The influence of sex hormones on the pathogenesis of PHO and its implication were discussed.


Over the last 16 years, since Karl Joreskog first introduced the LISREL model', the covariance structure model has gained considerable popularity among serious researchers in many research and applied fields. This has happened for two reasons. First, covariance structure models depict in a natural way the "causal" models researchers have in mind when thinking about the processes they are looking at. And equally important, the computer software has simplified the estimation of the parameters of covariance structure models, making it possible to estimate large, sometimes intricate, models using an uncomplicated syntax. With other methods of analysis, the method itself often determines the features of the model, and these are thus nonintuitive to the researcher. A loglinear model for 10 or 15 observed variables can produce a staggering number of parameters, many without clear theoretical implications. A covariance structure model, on the other hand, can be represented by intuitive path diagrams that do not require math courses to understand. And the estimated coefficients generated by the computer software are directly analogous to regression coefficients in multiple regression (which in fact may be regarded as a special case of the general covariance structure model) and have identical substantive interpretations. Covariance structure models are particularly useful in survey research where the number of variables can be large and the researcher envisions many "causal" connections among them. But the large survey also presents another theoretical problem that covariance structure models can handle with ease:


This article is a first and incomplete report about the provenance research at the library of the Kunsthistorisches Museum. After a short survey of the library's history, we discuss the sources and methodology for this study. Finally we outline first traces that we have found in our research since January 2011.


A new immunoassay for determination of α-fetoprotein by copper ion labelling and copper ion catalysis is reported in this paper. This copper ion substitutes for savageness enzyme as labelling element and combines to α-fetoprotein molecule by multifunctional regent. After competitive immunorration with antibody out of phase,the label copper ion is released by strong acid and measured by catalytic spectrophotometry which is based on the catalysis of copper ion to the reaction of o-methoxyphenol-ammonium persulfate in boric acid-sodium hydroxide buffer medium, and α-fetoprotein in sample is indirect detected. This method has a concentration linear range of 10~1 000 ng/mL of α-fetoprotein and has been used to determine α-fetoprotein in serum sample with satisfactory results.


In many practical situations, we know the lower and upper bounds G and G on possible values of a quantity G. In such situations, the probability distribution of this quantity is also located on the corresponding interval [G, G]. In many such cases, the empirical probability distribution has the form d(G) = const · (G − G)− · (G − G)+ · G . In the particular case U− = U+ = 0.5 and U = −1, we get the Marchenko-Pastur distribution that describes the distribution of the eigenvalues of a randommatrix. However, in some cases, the empirical distribution corresponds to different values of U−, U+, and U. In this paper, we show that by using the general idea of scale-invariance, we can provide a theoretical explanation for the ubiquity of suchMarchenko-Pastur-type distributions. 1 Formulation of the Problem Some distributions are located on an interval. For many physical and economic quantities G: • there are is a lower bound G on its possible values and • there is an upper bound G on its possible values. Kevin Alvarez. Vladik Kreinovich, University of Texas at El Paso, 500 W. University, El Paso, TX 79968, USA e-mail: email@example.com, firstname.lastname@example.com, Chon Van Le International University of Ho-Chi-Minh City, Vietnam, e-mail: email@example.com


The strength evaluation of adhesively bonded scarf joints having adherends of the same or dissimilar metal was investigated both analytically and experimentally in order to accomplish a way of strength designing of adhesively bonded materials. The strain and stress distributions in the adhesively bonded joints were analyzed by means of the finite element method. The strengths were calculated on the basis of our criterion. The effect of the mechanical properties of adherends on the joint strength was examined. The deformation state and fracture mode of the joints having adherends of the same metal. It was predicted that the smaller the difference in the Young's moduli between the adherends, the greater the joint strength was.


In this work, we use genetic algorithm(GA) for Ramsey graphs. Two versions of this algorithm are based on CPP and MATLAB.


A complex NLP application such as a question answering system requires sophisticated methods for evaluation, especially if there is a mechanism to submit factoid type queries as well as natural language (NL)-type questions. As part of our research we created an integrated tool that allows users to search two ways – using a keyword query and using a NL question. We present a method to evaluate output from the two types of searches and we explore the correlation of scores when judgments of output are made against keywords and those made against NL questions. We present a preliminary model, which may serve as a guideline to evaluate similar systems' performance.


This paper presents an overview of present concerns within EUCAR, the research association of European car manufacturers. Safety has to be worked at and means aiming for a near-zero accident rate: systems in and out of the vehicle are required. The interaction of driver and vehicle is critical: the workload imposed on the driver must be one capable of being undertaken by any person. Safety is divided into preventive and active functions. Complex active safety functions including anti-collision systems have to integrate many components and co-operation is required between manufacturers, researchers and governmental agencies. Driver-car interaction provides assistance to the driver to reduce the amount of attention spent on non-driving tasks. For the covering abstract see ITRD E111392.


This paper proposes a method that uses a wavelet transform (WT) and a fuzzy neural network to select the minimum number of features for classifying normal signals and epileptic seizure signals from the electroencephalogram (EEG) signals of people with epileptic symptoms and those of healthy people. WT was used to select the minimum number of features by creating detail coefficients and approximation coefficients from EEG signals. 40 initial fe atures were obtained from the created wavelet coefficients using statistical methods, including frequency distributions and the amounts of variability in frequency distributions. We obtained 32 minimum features with the highest accuracy from the 40 initial features by using a non-overlap area distribution measurement method based on a neural network with weighted fuzzy membership functions (NEWFM). NEWFM obtains the bounded sum of weighted fuzzy membership functions (BSWFM) for the 32 minimum features to identify fuzzy membership functions for the 32 features. Using these 32 minimum features as inputs in the NEWFM resulted in a performance sensitivity, specificity, and accuracy of 99.67%, 100%, and 99.83%, respectively.


We employed the simple but elegant technique ab-initio random structure searching (AIRSS) in finding the lowest energy structures, as well as some higher energy ones, of small Lin (n = 5-8) atomic clusters. Initial Lin cluster configurations were generated at random following certain structural constraints, and were optimized quantum-mechanically via density functional theory calculations. Our results show that AIRSS were able to find the most stable structures for all the considered Li cluster cases, in exact agreement with previous works. Furthermore, the calculated bond lengths and cluster cohesive energies are consistent with the literature. Our work demonstrates the applicability of AIRSS in the assessment of lowest and interesting higher energy structures of small Li clusters, and could also be of use in the comprehensive analysis of stable structures for large atomic clusters.


A comprehensive description of recent researches on the preparation meatod of lead dioxide electrode including its electrodeposition mechanism, substrate, surface doping and technical condition was presented. Finally, further research efforts were discussed.


122 Background: Two major components of breast cancer survivorship care include surveillance with mammograms and clinic visits after completion of definitive treatment. Identifying disparities in adherence to survivorship care is critical for improving the care delivery and outcomes of patients.

METHODS
We evaluated adherence to survivorship care among 4,212 racially/ethnically diverse Texan residents who underwent surgery for stage I-III breast cancer at the MD Anderson Cancer Center between January, 1997 and December, 2006 and completed one year of survivorship care. We used generalized estimating equations (GEE) method to evaluate race/ethnicity differences in missed mammograms and clinic visits up to 4 years of survivorship care.

RESULTS
The mean age of the cohort was 53 years (range 22-91); 72% white, 11% black, 11% Hispanic and 5% other race/ethnicity. Over four years, 36% of patients missed an annual mammogram and 21% of patients did not have a minimum of 1 clinic visit per year. For the entire study cohort, the trend of missed annual mammograms per year of survivorship care follow-up was 6% (year 1), 17% (year 2), 19% (year 3) and 22% (year 4) (p-trend <0.0001). In multivariable GEE model adjusted for survivorship year, age, stage, chemotherapy, endocrine therapy, radiation therapy and county of residence, Hispanic (OR 1.48 95% CI 1.22-1.80) and black (OR 1.41, 95% CI 1.15-1.72) patients were more likely be nonadherent with annual mammograms compared to white patients. Hispanic (OR 1.58, 95% CI 1.25-2.00) and black (OR 1.45, 95% CI 1.14-1.84) patients were also more likely to be nonadherent with clinic visits compared to white patients. There was a significant interaction between ethnicity and non-receipt of adjuvant endocrine therapy on clinic visit nonadherence (p-interaction=0.04) and annual mammogram nonadherence (p-interaction=0.001) among Hispanic compared to white patients.

CONCLUSIONS
Drop out of breast cancer survivorship care increases over time and black and Hispanic women are more likely to be nonadherent. Better characterization of the reasons for nonadherence is needed to design interventions to improve retention in breast cancer survivorship care, especially for patients not receiving adjuvant endocrine therapy.


Background: The objective was to measure the sensitivity of a group of physicians regarding the ethics-related situations, which they faced during patient care and treatment. Methods: All of 306 physicians who joined the Turkish Army for compulsory military service in December 2008 were included in the study. A "Moral Sensitivity Questionnaire", formed by Kim Lutzen, was applied to all of them. Results: From total, 95% of physicians performed their job willingly, 88% of physicians attended ethic lessons (n=265), 72.4% (n=218) followed ethic publications, 67.4% (n=203) stated that there was an ethic committee at their institutions, and 5% worked as a member of the ethic committee. There were statistically significant differences between autonomy, benevolence meaning, conflict, and total scores according to workplace of physicians, employment period, and being specialists. Points of autonomy were found lower in physicians working at private hospital and health center than those at public hospital. Conclusion: Ethical sensitivity of physicians changed due to work place. We conclude that organizational arrangements are of beneficial effects to increase ethical sensitivity.


The structural bionicism of the knee joint of an automobile crash dummy is an important factor affecting the accuracy of the dummy's knee displacement and knee flexion angle measurements in automobile crash tests. This study focused mainly on the optimization of the bionic structure of the knee joint of an automobile crash dummy to ensure that the dummy has a kinematic response closer to that of the knee joint of a real human. Forty sets of high-speed photographic images of the sphyrion were acquired by performing a trajectory-measurement test at the lower tibial point. Subsequently, the high-flexion motion trajectory of the knee joint was obtained by solving vector equations and by multicurve fitting. This trajectory, combined with the bionic structure design method, optimized the structure of the existing dummy's knee joint. Thereby, its motion can be altered from a fixed-axis rotation to a non-fixed-axis curve motion close to how the human tibial plateau rotates around the femoral condyle. This increases the degrees of freedom of the dummy's knee joint from two to three. The knee joint structures before and after the optimization were simulated kinematically using a multibody dynamics method. The results showed that the peak of the motion trajectory deviation of the optimized sphyrion decreased from 3.7% to 1.9%, and the average deviation decreased from 2.0% to 0.2%. This indicates that the structural optimization scheme improved the motion bionics of the crash dummy's knee joint.


The ever-growing demand for accurate machine learning models resulted in an increase in dataset and model sizes of deep neural networks. This paper discusses reconfig-urable optical networks as the key enabler for scaling AI systems. © 2022 The Author(s)


Abstract : System analysis steps: 1. Identify the customers need, 2. Evaluate the proposed system for feasibility, 3. Perform economic and technical analysis, 4. Allocate function to hardware, software, people and data (database), 5. Establish cost and schedule constraints and 6. Create a system definition.


One might well begin with the conclusion: 'It is quite obvious that computer systems are rapidly being accepted on Norwegian ships' although shipping opinion is still divided into two camps, the believers and the agnostics. The believers foresee a single large computer or several smaller systems covering most functions on board, the doubters think that computers are a passing fancy. There has certainly been too much talk about computers as if they were an end in themselves—the computer is an aid; in Noratom-Norcontrol we look on it as a component which enables us to solve certain system problems we were unable to tackle before, or to solve them better.


[Background and Objectives] Alzheimer's disease (AD) is a progressive neurodegenerative and the most common disease of elderly dementia in the world. Acetylcholinesterase inhibitors such as donepezil and rivastigmine are the most useful drug for AD, but they are only used as symptomatic treatment and not disease-modifying drugs. We here developed a disease-modifying drug, SAK3 which stimulates T-type calcium channels and ameliorates AD pathology. Here, we introduce the novel mechanism through proteasome activation to inhibit Aβ deposition in App NL-G-F/NL-G-F knock-in (NL-G-F) mice. [Methods] NL-G-F mice were chronically administered with SAK3 (0.5 mg/kg, p.o.) for 3 months. (i) Proteasome activity was assayed by fluorogenic peptides. (ii) Immuno-blotting analyses were conducted to assess CaMKII-Rpt6 pathway. (iii) The number and morphology of spine were assessed in vivo . (iv) Behavioral analyses were carried out to assess cognitive functions. [Results] (i) The decreased 26S proteasome activities in the cortex of NL-G-F mice were restored by SAK3 chronic administration. (ii) The declined levels of phospho-CaMKII and phospho-Rpt6 in the hippocampus of NL-G-F mice were restored by SAK3 administration. (iii) The decreased number and abnormal morphology of spine in the cortex and hippocampus of NL-G-F mice were improved by SAK3 administration. (iv) The impaired cognitive function in NL-G-F mice was improved by SAK3 treatment. [Conclusions] We defined the novel mechanism of SAK3-induced proteasome activation, thereby inhibiting the amyloid aggregation in AD mice. These results strongly suggest that SAK3 is the disease-modifying therapeutics for


The primary motivation for the work described in this paper is to design a platform for building applications that are intended for use by a group of people. The paper introduces the requirements for applications in which people use workstations on a local area network to share information and to communicate with one another. The paper discusses how we addressed these requirements in the context of three example applications a departmental database, a room booking program and a shared spreadsheet.


The study aimed at management of outsourcing of National Forest Plantation Development Programme (NFPDP) and its effects in the Atebubu Forest District as a case study in Ghana. The key issues examined are the level of technical competence of the contractors, the role of the lead implementing agency and the natural resource base sustainability. Two stage sampling technique was used to sample one hundred and ten respondents for the study. A structured questionnaire was used to solicit information from the respondents. Descriptive and inferential statistics were used to analyse the data. The results of the study indicate that the award of seedlings contracts and workers' salaries and logistics to African Foresters Brigade and Zoil Ghana Limited respectively were transparent. However, most of the activities the participating institutions performed were behind schedule indicating poor performance. It is therefore recommended that, Forestry Commission should put in place proper modalities to ensure effective implementation if outsourcing is to be continued.


Analyzing interspecific segregation helps reveal species interactions, community structure and dynamics. We established 36 quadrats and drew a distribution map for 27 species numbering 10 or more. Using ArcView GIS software and the nearest-neighbor method,interspecific segregation was studied with an N × N nearest-neighbor contingency table,a 2 × 2 nearest-neighbor contingency sub-table,and Pielou's coefficient of segregation for the individual tree species. Distribution patterns were measured by a revised Clark-Evans index( CE) and the widely-used χ2method. Results showed that:( 1) three tree species were clumped,and the others were random;( 2) Most species pairs were positively segregated( 59. 83%),some species pairs were randomly segregated( 40. 17%),and no species pairs were negatively segregated;( 3) Some differences existed among different species in the interspecific segregation of all species. Larger individuals representing dominant species in the communities tended to be positively segregated with other large trees,though sometimes tended to random segregation;( 4) Interspecific segregation was closely related to distribution patterns. There was a larger proportion of positive segregation between clumped species and other species than there was negative segregation. Most random segregation occurred between random species,which also caused slight positive or negative segregation;( 5) The27 species overlapped in distribution and were characterized by overall non-segregation.


-----------------------------------------------------------------------------------------------------------------------------------ABSTRACT :Concrete industry consumes considerable quantities of natural resources and releases toxic gases, such as carbon dioxide, into the atmosphere. Using alternative renewable resources to produce concrete, such as palm oil waste, would increase sustainability in the concrete sector. Using palm oil fuel ash (POFA) instead of cement in concrete is an effective practice for reducing costs and environmental impact when using waste materials such as palm kernel shells, palm oil fibers, and palm oil husks. the study aims to examine the effects w/b ratios and grounded palm oil fuel ash (POFA) on mechanical properties, chloride resistance, and water permeability of concrete. POFA grounded to size 75-micron and used as a partial replacement for cement at a rate of 12%, 24%, and 36% by weight of the binder to cast high strength concrete (HSC). And, the water to binder ratio (w/b) was ranged between 0.45 to 0.52. Properties such as mechanical strength, water permeability, and chloride resistance of HSC were determined at 7, and 28days. The pozzolanic reaction of grounded POFA increases with an increase in the replacement rate of cement and with the age of concrete. The results indicate that POFA is a reactive pozzolana and can be used as supplementary cementitious material by partially replacing cement in OPC.


In ancient times, there was a navigation notebook to guide sailors. Currently, there are tutors and teachers. And is it that tutors are not in charge of guiding children in the process of teaching and learning?


Alfalfa disease is one of major factors which hinders the sustainal development of alfalfa industrial of Xinjiang,so studies on Alfalfa disease have been carried out for many years.Up to now,24 alfalfa diseases and 35 pathogens were reported.Among them,biological characters of Verticillium albo-atrum,Pseudopeziza medicaginis,Rhizoctonia solani,Peronspora aestivalis,Leveillula leguminosarum and the laws of Brown spot,Downy mildew,Powdery mildew were researched partly,but the others are waiting for research.In this article,the studies on kinds of disease,identification of pathogens,biological character,disease law and control on alfalfa disease were summarized.Moreover,some questions and countermeasures were raised.


Tranexamic acid (TA) is an antifibrinolytic drug used for the control of hemorrhages in the different disciplines of medicine. In otorhinolaryngology (ENT) it has multiple applications, both surgical and non-surgical, however, its effectiveness and safety have been controversial over time. Below is a review of the literature regarding this drug and its use in ENT, for divulgation in our environment


This article from had expounded in the contact surface design the emotion factor's importance,and obtained from the emotion cognition's three horizontal levels to analyze has proven the contact surface sentiment influence design.


The hydraulic parameters are important for the numerical computation in which hydraulic conductivity is one of the most frequent. The horizontal component of hydraulic conductivity could be obtained with field trial. And the vertical component is usually computed with the horizontal one by dividing a constant. However, this procedure always generates significant errors which are illustrated by the theoretical analysis and numerical comparison study. For practical engineering application, a brief algorithm to compute the vertical conductivity is proposed and checked by a numerical model. Introduction Hydraulic conductivity, symbolically represented as K, is a property of soils and rocks that describes the ease with which a fluid (usually water) can move through pore spaces or fractures. It depends on the intrinsic permeability of the material, the degree of saturation, and on the density and viscosity of the fluid [1]. The hydraulic conductivity is often considered as a vector in 3-D space and the horizontal component and the vertical one are different. In practical groundwater engineering, the hydraulic conductivity is one of the most important parameters concerned to the computational accuracy. The horizontal conductivity could be obtained with field trial while the vertical one could not. And the vertical one is used to be computed with the horizontal one by dividing a constant, 2-10. However, the vertical one is usually much less than one tenth of the horizontal one when two or more materials are defined as one aquifer. Then, the vertical conductivities of those aquifers become larger and the hydraulic conductivities of aquitard, including horizontal component and vertical one, becomes less. In the other situations, the vertical conductivity of one model is assigned larger which make the fluxes through aquitard much larger. To solve this problem, the models with different materials are researched by theoretical and numerical computation. The parameters for different materials The hydraulic conductivity of aquifers is a complex physical quantity. It varies with the materials, the fracture development, the geologic structure and a lot of factors. In this study, we consider mainly the materials. And for different materials, we used the empirical value by Zheng [2] as shown in Table 1. Table 1 Hydraulic conductivity of different materials (m/day) Materials Scope Selected value Gravel 25.9-2592 250 Grit 7.8×10-518.4 10 Medium Sand 7.8×10-43.2 2 Fine Sand 1.7×10-17.3 0.7 Silt 8.6×10-1.7 1.5×10 Moraine Clay 8.6×10-0.2 8.6×10-4.3×10 1.5×10 2×10 The scope data is recomposed form Zheng and Bennett (2002). The selected value with the middle exponent will 5th International Conference on Environment, Materials, Chemistry and Power Electronics (EMCPE 2016) © 2016. The authors Published by Atlantis Press 302 be used in the following computation. For different materials, the ratios of vertical and horizontal conductivities are also different. Fetter [3] and Weeks [4] have researched the ratio with gravels and sands which are between 2 and 20. Kong [5] and many other engineers [6] discussed that ratio with clay. Its vertical conductivity is almost one fourth or tenth of that horizontal one. With the loess, the ratio is obvious different. The vertical one is bigger that are twice or triple horizontal conductivity [7-9]. And in the plain area, many researches have checked that it is reasonable for the ratio, one tenth, with single material [10-12]. In this study, we apply one fifth as the ratio for each single material. Theoretical analysis In theory, the vertical conductivity could be computed considering each material parameter with the following equation that


Background: The prevalence of idiopathic scoliosis is rapidly increasing in Korean children, but research on the disorder is limited compared to that in other countries. Accordingly, in the present study, we aimed to investigate the relationship between idiopathic scoliosis and body mass index (BMI) levels in Korean children. Methods: This cross-sectional study enrolled elementary school students and middle school first graders in the Capital Area in Korea. The participants underwent body composition measurements and screening for idiopathic scoliosis. Idiopathic scoliosis was defined as a Cobb angle of ≥10°. The students were classified into three groups—the severely underweight (SUW: BMI < 16 kg/m2) group, the underweight group (UW: 16 ≤ BMI < 18.5 kg/m2), and the normal weight group (NW: 18.5 ≤ BMI < 25 kg/m2) to compare the risk of idiopathic scoliosis across BMI levels. Results: The final cohort comprised 1375 participants. The odds ratio (OR) of idiopathic scoliosis was 0.69 (95% confidence interval (CI): 0.50–0.94) and 0.66 (95% CI: 0.49–0.89) for the UW and the NW groups, respectively, with the SUW group as the reference. This shows that the risk decreased significantly by 31% and 34% in the UW and the NW groups, respectively. After controlling for age and sex, the corresponding ORs were 0.72 (95% CI: 0.52–0.98) and 0.70 (95% CI: 0.51–0.96), and the risk significantly decreased by 28% and 30% in the UW and the NW groups, respectively. Conclusions: Low body weight is closely associated with spinal deformity and idiopathic scoliosis.


TVT-S is the third generation of tension-free vaginal tapes. There are two possible insertion methods: the H-position and the U-position. It was claimed that this tape, using less foreign material, would achieve higher efficacy and a reduction of the complication rate in comparison to the previous methods [1]. The aim of the study was to evaluate the fixation site of the TVT-S tape and to explain possible haemorrhagic complication [2]. We hypothesize that fixation site will be crucial for long-term efficacy of the method.


Due to the personalized and diverse service needs, service scheme configuration should be more quick and flexible in the process of product service system (PSS) scheme design. Service modularization can effectively improve the service configuration efficiency and modules' reusability. However, compared with the modularity of tangible products, the partition of service modules in the practical context is still a problem to be discussed. In this paper, a service partition approach for PSS based on the fuzzy graph and Dempster-Shafer theory of evidence is presented. Firstly, service activities correlation analysis is carried out, according to which the fuzzy graph is drawn. By setting different thresholds, the fuzzy graph is cut, and different partition results are obtained. Secondly, the evaluation indexes of customization, generalization, and technological evolution are proposed and used as evidence sources of the Dempster-Shafer theory of evidence. Through the synthesis of the evidence sources, the optimal partition scheme is got. Finally, to verify the method, a case study is illustrated through the NC machine tools module partition. And results show that the proposed method can provide specific ideas and concrete guidance of the service module partition.


This study analyses the impact of politics on urban development and, in particular, on Timurid heritage in present-day Uzbekistan. It outlines the problem of landscape manipulation for the advancement of a political ideology. After presenting a brief overview of Tsarist and Soviet restoration practices, the article focuses on the post-Soviet nation-building schemes through public iconography, urban renewal measures and heritage construction. Architectural and epigraphic restorations of Timurid monuments in Samarqand and new constructions in Tashkent provide a valuable illustrative framework. As world heritage sites, the Samarqand monuments are examined both in their historical and current socio-political contexts; the role of UNESCO is also analysed. The study benefits from and contributes to critical heritage studies and urban development as a narrative of power-making and relational space.


This paper calls into question a consensus belief that the term "ti"帝 (and the term "shang-ti" 上帝), as used in the Shang oracle texts, denoted a supreme deity. Such an interpretation of the term is entirely satisfactory for textual sources postdating the first century of Chou rule, but the evidence of Shang texts suggests that term ti was employed therein as a corporate term denoting deities collectively, as a generic term referring to members of the Shang pantheon individually but not by name, or as an honorific term for the father of the Shang ruler. By exploring the semantics of the term ti through Shang usage and cognate words, a speculative root meaning of "father" is proposed, the graph being a representation of the ancestral altar or of altar figures. If this theory is valid, it calls into question the extent to which proto-bureaucratic features can be ascribed to the Shang pantheon. It also suggests that the concept of supreme divinity in China was either derived from the pre-conquest religion of the Chou, centered upon the deity T'ien, or through a post-conquest universalization of the Chou religion.


We construct a new class of stationary exact solutions to five-dimensional Einstein–Gauss–Bonnet gravity. The solutions are based on four-dimensional self-dual Atiyah–Hitchin geometry. We find analytical solutions to the five-dimensional metric function that are regular everywhere. We find some constraints on the possible physical solutions by investigating the solutions numerically. We also study the behavior of the solutions in the extremal limits of the Atiyah–Hitchin geometry. In the extremal limits, the Atiyah–Hitchin metric reduces to a bolt structure and Euclidean Taub–NUT space, respectively. In these limits, the five-dimensional metric function approaches to a constant value and infinity, respectively. We find that the asymptotic metrics are regular everywhere.


The Jenderal Sudirman area has a strategic function as a trade and service area that gives strong character in the Salatiga. The growth of trade and service activities has increased to become a regional trading area that is influenced by modern trade. With the existence of modern shopping centers, five-star hotels, banking services beside the existing traditional markets affect the increasement of activities. The high intensity of activities raises problems related to traffic congestion. The purpose of this research is to determine the performance of the road network in the Jenderal Sudirman area and formulate a traffic management strategy to deal with the current traffic problems. This research was conducted by analyzing the existing conditions. The method of calculating volume, degree of saturation, and speed used is MKJI 1997. This study uses the SATURN 10.4 program to determine overall network performance. The results showed that the existing condition of the Jenderal Sudirman area undergone problems in Jalan Jenderal Sudirman (2 directions) with 0.86 degree of saturation. The first scenario analysis shows the value of the degree of saturation in Jalan Jenderal Sudirman dropped to 0.55; The Second scenario analysis to 0.90; and the third scenario analysis becomes 0.98. As for the overall network performance, first scenario has advantages on 3 indicators, namely average speed, passenger car unit(pcu)-hour, pcu-rupiah. Based on the overall analysis, a concept of handling traffic problems can be arranged by applying the traffic management strategy first scenario and second scenario through the short-term and long-term stages.


Proteid is one of the chief composition of organism,its structure and character decides the properties and function of organism.Studying the structure and zymogram of proteid is important to realize the organism evolution and classification.This paper summarizes concepts, studying scopes and application of evolutional systematics of proteid in reptiles.


The interactions of people in organizations around certain types of problems and issues can be seen as analogous to a complex adaptive system. Traditional approaches to management of these problems, whereby it is attempted to establish order and control through the actions of a few at the top has been shown repeatedly to fail. Many persist with this pattern of behavior, ironically often moving problems closer to the edge of chaos than closer towards certainty. The ! rst step in changing this pattern is to recognize that the style of engagement needs to shift to that more like a set of complex responsive processes. The methodology outlined in this paper is one such approach, a dialogue and discernment that invariably handles complexity well and leads to positive outcomes. It has been widely used in a variety of settings and sectors and it is highly adaptable to a range of purposes.


We study the Knapsack Problem with Conflict Graph (KPCG), an extension of the 0-1 Knapsack Problem, in which a conflict graph describing incompatibilities between items is given. The goal of the KPCG is to select the maximum profit set of compatible items while satisfying the knapsack capacity constraint. We present a Branch-and-Bound approach to derive optimal solutions to the KPCG in short computing times. Alternative dual bound procedures are compared, as well as different branching strategies, and new effective ones are proposed. Extensive computational experiments are reported, showing that the proposed method outperforms an existing approach from the literature and a Mixed Integer Programming formulation tackled through a general purpose solver.


One of the important aspects of development is the understanding social values and the object of teaching moral values that create self-preservation and acquiring power opposing by discriminating the illogical inclination. It is therefore it is needed to recognize the moral balance and being equal the moral scale in action. Or the output of the result, moral or immoral. There are three stages of the moral growth in the different cultures that are firm and unchangeable. The present research work has the object to study the moral growth in young girls, whom cross road of secondary school stage. There administrative relation with their parents. This work is based on two stage, of middle school and senior secondary stage. For the moral growth of the youths, moral texts to make at the base of Kohlberg's moral test; by looking at the administrative relations with the parents for that purpose a questionnaire to be prepared. The date collect on the base of that. The analysis to make on the base of statistics. The result living in the democratic atmosphere is lead to higher moral growth than living in Participatory administrative system. Also, the results of participatory leadership of parents are lead to growth in morality of adolescences.


The term "middleware" is used to identify software services and products that enable an integration communication model between application, data, business process, and web services especially in heterogeneous environments to be created and supported. In this paper, I propose that the enterprise service bus (ESB) middleware under the service-oriented architecture (SOA) can enable communication between the front and back-end layers of SOA integration that connects users with a data management layer. Including in this data management layer is a near-real-time data warehouse in addition to routing, security, message processing, and modeling capabilities. An ESB is one platform that helps achieve and support enterprise-wide SOA. The main issue to be addressed is the provision of access to a company-wide view of data wherever it resides. This is accomplished by building the SOA integration on top of the data warehouse. This will also use ESB middleware for integration solutions for existing applications and new business processes, along with the ability to pass data to any integration level. Most companies in the 21st century face increasing challenges to stay competitive, and accessibility and accuracy of information have become critical success factors. The traditional role of a data warehouse has been to support strategic decision making. This role has expanded to include more critical business tasks that support both strategic decisions and operational business processes. ESB has become an important part of the architectural framework for a business intelligence solution and is considered a critical component in the architecture of advanced near-real-time data warehouses.


The Weda Formation in Lili River, Dorosagu, East Halmahera consists of siliciclastic and pelagic carbonates deposited in a submarine fan environment. Research on the Weda Formation in the northern part of Halmahera Island is relatively minimal because most of the research about this formation has been carried out in the southern part of Halmahera Island. The lack of road access and its remote location have resulted in the lack of intensive research on this formation. This study aims to determine the relationship between the intensity and diversity of trace fossils in the submarine fan facies association of the Weda Formation. Sedimentological studies include sedimentary texture, sedimentary structure, turbidite material type, and layer thickness. While the study of trace fossils includes the identification of trace fossil types, classification of behavior, intensity, and diversity in sedimentary layers, and the factors that influence them during deposition. There are eight types of ichnofossil observed in the Lili River, Ophiomorpha, Thalassinoides, Rhizocorallium, Palaeophycus, Zoophycos, Chondrites, Lorenzinia, and Spirorhaphe, which are found in three facies associations (AF): submarine fan channel facies association (AF1), submarine fan lobe facies association (AF2), and submarine fan distal facies association (FA3). The submarine fan channel facies is characterized by the presence of Ophiomorpha and Thalassinoides which present in low intensity and low diversity due to unstable environmental conditions-high stress due to intensive turbidite currents. The submarine fan lobe facies shows a higher density and diversity where ichnofossil is classified into two based on the substrate in the flysch deposits. Rhizocorallium, Thalassinoides, and Palaeophycus ichnofossil were formed in the sand substrate, while Zoophycos and Chondrites ichnofossil were formed in the shale substrate. Palaeophycus, Zoophycos, Chondrites, Lorenzinia, and Spirorhaphe ichnofossil were found in the submarine fan distal facies associated with high intensity indicating low energy levels and low sedimentation rates.


Abstract Background. Respiratory syncytial virus (RSV) lower respiratory tract disease (LRD) is a life-threatening complication in hematopoietic cell transplant (HCT) recipients. Lymphopenia has been associated with an increased risk of progression from upper respiratory tract infection (URI) to LRD. Methods. This study retrospectively analyzed the significance of lymphocyte engraftment dynamics, lung function, smoking history, corticosteroids, antiviral treatment, viral subtypes, and RSV-specific neutralizing antibodies for the progression to LRD in 181 HCT recipients with RSV URI. Results. In multivariable models, smoking history, conditioning with high-dose total body irradiation, and an absolute lymphocyte count (ALC) ≤100/mm3 at the time of URI onset were significantly associated with disease progression. No progression occurred in patients with ALCs of >1000/mm3 at URI onset. Lymphocyte engraftment dynamics were similar in progressors and nonprogressors. Pre- and posttransplant donor and posttransplant recipient RSV subtype-specific neutralizing antibody levels, RSV viral subtypes, and corticosteroids also were not significantly associated with LRD progression. Conclusions. Host and transplant related factors appear to determine the risk of progression to LRD more than viral factors. Dysfunctional cell-mediated immunity appears to be important in the pathogenesis of progressive RSV disease after HCT. A characterization of RSV-specific T-cell immunity is warranted.


Based on the situation which student,physical fitness has become worse in our country.With the methods of literature,interviewing,statistic analyzing,the paper does some analysis on development and change of student,physical fitness of Han,Uygour,Mongolians,and Kirks Nationality during five years from 2000 to 2005 and found some factors which influence physical fitness,such as society,education system,school,family,students,and traditional attitude and so on.Suggestions were thus put forward to development of school sports.


This study uses life satisfaction scale and life events scale when sampling 504 teachers in rural compulsory education to understand the state of life satisfaction and its relationship to life events and coping styles under the context of the new curriculum for compulsory education in rural areas to improve their quality of life.Life satisfaction realities on the part of teachers were shown significantly negative correlation with five dimensions of the life events,while positive correlation with active coping style.Regression analysis showed that the work achievement,organizational management,social support and active coping styles impacted life satisfaction significantly(P (0.01)).


The article is devoted to an actual problem of a constitutional law, features of the mechanism of realization of constitutional legal principles, materials of judicial and notarial practice are given, legislation suggestions for improvement become.


Verification of concurrent algorithms has been the focus of much research over a considerable period of time, and a variety of techniques have been developed that are suited to particular classes of algorithm, for example algorithms based on message passing or mutual exclusion. The development of nonblocking or lock-free algorithms, which rely only on hardware primitives such as Compare And Swap, present new challenges for verification, as they allow greater levels of currency and more complex interactions between processes. In this paper, we describe and compare two approaches to reasoning about nonblock- ing algorithms. We give a brief overview of the simulation approach we have used in previous work. We then give a more detailed description of an approach based on Lip- ton's reduction method, and illustrate it by verifying two versions of a shared counter and two versions of a shared stack. Both approaches work by transforming a concur- rent execution into an equivalent sequential execution, but they differ in the way that executions are transformed and the way that transformations are justified.


The self-starting performance and aerodynamic characteristics at low wind speeds are the two main problems for the straight-bladed vertical Axis wind turbine (SB-VAWT). In this study, a new kind of wind-gathering device (WGD), which can be installed up and down the rotor, with a polyline hexagonal pyramid shape, was proposed. Both the numerical simulation and the wind tunnel test were performed on this WGD. Based on the method of quadratic rotary orthogonal combination design, the effect of the main structural parameters of the WGD on the self-starting performance of the SB-VAWT was researched by 3D numerical simulation. The optimal combination of the main structural parameters for the WGD under the condition of this study was obtained. Furthermore, wind tunnel tests were carried out on the SB-VAWT with and without the WGD having the optimal structural parameters, including the starting performance, power performance, and rotational revolution performance. The results showed that both the static performance and dynamic performance of the SB-VAWT were increased to some degree by installing this kind of WGD. The improvement is more obvious under the condition of low wind speed. This research can be a useful reference for the in-depth study on the optimal WGDs for the SB-VAWTs.


Essentials Imaging is warranted in the majority of patients to confirm or rule out pulmonary embolism (PE). The age‐adjusted D‐dimer (ADJUST) reduced the number of required imaging tests in patients ≥ 50 years. The YEARS algorithm was designed to improve the efficiency in patients with suspected PE. There was no added value of implementing ADJUST in the YEARS algorithm in our cohort.


According to the World Health Organization data, chronic obstructive pulmonary disease (COPD) kills more than 2.75 million people each year. Infections cause COPD recrudescence in 50-80% of the cases and the speed of disease progression depends on the early and appropriate antibiotic application. Materials and methods. Literature review. Prospective, multicenter, open, non-comparative study in 54 outpatient centers in 24 cities of the Russian Federation. The aim of the study is to determine the clinical efficacy of levofloxacin (Tavanic®) in patients with exacerbation of infectious of COPD, and to estimate the length of remission and the frequency of hospitalizations on monitoring patients during the 12 months after the end of therapy. Results. We showed the high clinical efficacy of levofloxacin (Tavanic®) in case of exacerbation of COPD with stable results and the absence of recurrence within 12 months. The results of the study showed that levofloxacin is one of the most effective antibiotics in such patients and can be considered as the first-line treatment, especially in cases of severe situation – patients with COPD, significant airway obstruction and frequent exacerbations in case history.


MICHEL LE GUERN: Ellipsis in French Rhetoric from 1675 to 1765. French rhetoric in the classical age is divided into two main trends: traditional rhetoric, which goes back to Aristotle, Cicero, Quintilian, and sometimes St Augustine;. innovative rhetoric, based on the philosophical study of language, mainly exemplified by the oratorian priest Bernard Lamy. Ellipsis is one of the points on which the two trends differ. The word ellipsis itself hardly occurs in the rhetorical treatises that stem from the traditional school. This lack of interest is quite understandable in a type of rhetoric oriented towards abundance, repetitive emphasis and amplification. For Bernard Lamy, on the other hand, ellipsis is bath a figure of grammar and a figure of rhetoric, in a conception of language where figures are the linguistic expression of passion. Only in 1765, with Crevier, did the traditional trend integrate Lamy's views into its approach ta ellipsis.


This paper describes the development of Named Entity Recognition (NER) systems for two leading Indian languages, namely Bengali and Hindi, using the Conditional Random Field (CRF) framework. The system makes use of different types of contextual information along with a variety of features that are helpful in predicting the different named entity (NE) classes. This set of features includes language independent as well as language dependent components. We have used the annotated corpora of 122,467 tokens for Bengali and 502,974 tokens for Hindi tagged with a tag set of twelve different NE classes, defined as part of the IJCNLP-08 NER Shared Task for South and South East Asian Languages (SSEAL). We have considered only the tags that denote person names, location names, organization names, number expressions, time expressions and measurement expressions. A number of experiments have been carried out in order to find out the most suitable features for NER in Bengali and Hindi. The system has been tested with the gold standard test sets of 35K for Bengali and 50K tokens for Hindi. Evaluation results in overall f-score values of 81.15% for Bengali and 78.29% for Hindi for the test sets. 10-fold cross validation tests yield f-score values of 83.89% for Bengali and 80.93% for Hindi. ANOVA analysis is performed to show that the performance improvement due to the use of language dependent features is statistically significant.


The South African Medical Journal (SAMJ) was first published in 1884, and has therefore been in existence for 126 years in one form or another. The journal pays tribute to a journal buff who contributed considerably to its more recent history - for some 42 years, or exactly one-third of its existence. Tributes to Ralph Kirsch have been published in the SAMJ, but we would like to express our appreciation by outlining some of his many contributions to publications in South Africa and to the SAMA stable of journals in particular.


This Editorial highlights an article by Gulchina and colleagues in the current issue of the Journal of Neurochemistry, in which the authors describe molecular and epigenetic changes in the developing prefrontal cortex of the rats exposed to methylazoxymethanol acetate (MAM). They found an NMDAR hypofunction present in the prefrontal cortex of juvenile MAM rats which was associated with abnormal epigenetic regulation of the Grin2b gene. These changes may be related to early cognitive impairments observed in MAM rats and schizophrenia patients.


Nd:YAP laser emitting at 1,342 nm appears promising for nonablative skin rejuvenation treatment, based on favorable absorption properties of water and melanin in this part of the spectrum. A quantitative determination of energy deposition characteristics of Nd:YAP in normal human skin should enable design of a safe and effective treatment protocol for future human studies.


The electronic excitation spectra of Cs overlayers on Ag are calculated with use of the time-dependent density-functional approach. These spectra are found to undergo characteristic changes as the coverage increases from 0.5 to 2.0 monolayers. The nonlocal corrections to the Fresnel optics obtained from these spectra are in qualitative agreement with reflectivity measurements for p- and s-polarized light.