The issue of public disclosure of the design is regulated in Article 7 of Council Regulation (EC) no. 6/2002 of 12 December 2001 on Community designs. Pursuant to this provision, a design shall be deemed to have been made available to the public if it has been published following registration or otherwise, or exhibited, used in trade or otherwise disclosed, except cases where these events could not reasonably have become known in the normal course of business to the circles specialized in the sector concerned, operating within the Community. The design is made available to the public in a situation where these events could be known in the course of normal professional activity in an environment specialized in a given sector, operating within the Community. The list of methods of public disclosure contained in Article 7 of Council Regulation (EC) no. 6/2002 is not a closed catalog. Disclosure of the earlier design on the Internet causes difficulties in assessing whether it meets the conditions required for public access, i.e. whether the design could reasonably have become known in the normal course of business to the circles specialized in the sector concerned. Moreover, the disclosure of the design on the Internet generates problems of evidence related to proving the precise date of its disclosure to the public. The article analyzes the jurisprudence of the European Union Intellectual Property Office (EUIPO) and European jurisprudence in recent years. In particular, attention was paid to the issues of evidence necessary to recognize that the Community design was made available on the Internet. The article concerns a topic that is current both among representatives of the doctrine and in jurisprudence (Polish and European). It has theoretical and practical significance, because the issue of evidence submitted by the parties on the fact that an industrial design is made available to the public is very often a problem at the stage of court proceedings.


Triplex DNA has attracted considerable interest because of its possible biological function in vivo and its wide variety of potential applications, such as regulation of gene expression. A triplex is formed through the sequence-specific interaction of a single-stranded homopurine or homopyrimidine triplex-forming oligonucleotide (TFO) with the major groove of homopurine-homopyrimidine stretch in duplex DNA. In the pyrimidine motif triplex, a homopyrimidine TFO binds paral lel to the homopurine strand of the target duplex by Hoogsteen hydrogen bonding to form T A:T and C G:C triplets. Extreme instability of the pyrimidine motif triplex at physiological pH severely limits its utility for artificial control of gene expression in vivo. Stabilization of the pyrimidine motif triplex at neutral pH is, therefore, of great importance to improve its therapeutic potential. We have previously shown that poly(L-lysine)-graft-dextran (PLL-g-Dex) copolymer (Figure 1) and 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) backbone modification of TFO (Figure 2) increased the thermal stability of the pyrimidine Nucleosides, Nucleotides, and Nucleic Acids, 24 (5–7):635–638, (2005) Copyright D Taylor & Francis, Inc. ISSN: 1525-7770 print/ 1532-2335 online DOI: 10.1081/NCN-200060113


An episodic mobile belt underlies the zone of geothermal springs in the Benue area of Nigeria. The close resemblance between the transverse gravity profiles for the Benue depression and profiles of the central Red Sea depression may indicate a similar origin for the depression. The Benue depression is an expression of a spreading ridge generated from a RRR triple junction which was active in the Early Cretaceous. Separation in the Benue trough ceased in the Late Cretaceous, and the spreading ridge is now defunct and at least partly obscured. In Neogene time, there was predominance of igneous activity in the Cameroon-Adamawa volcanic zone which has many attributes of an embryonic spreading ridge. Many of the Neogene alkaline volcanics in the Benue depression and on the Jos plateau trend northwest-southeast, roughly perpendicular to both the Benue depression and the Cameroon-Adamawa volcanic zone, and may mark the sites of future transform faults. It is postulated that the geothermal springs in the Benue area are surface expressions of a convective hydrothermal system associated with an embryonic spreading ridge or hot spot. It is also suggested that extraction of energy from this convective hydrothermal system, either for direct heat application or for conversion to electricity in the Benue area, is feasible. End_of_Article - Last_Page 898------------


In humans, blastocyst hatching and implantation events are two sequential, critically linked and rate‐limiting events for a prospective pregnancy. These events are regulated by embryo‐endometrium derived molecular factors which include hormones, growth factors, cytokines, immune‐modulators, cell adhesion molecules and proteases. Due to poor viability of blastocysts, they fail to hatch and implant, leading to a low 'Live Birth Rates', majorly contributing to infertility. Here, embryo‐derived biomarkers analysis plays a key role to assess potential biological viability of blastocysts which are capable of implantation and prospective pregnancy. Thus far, embryo‐derived biomarkers examined are mostly immune‐modulators which are thought to be associated with blastocyst development‐implantation and progression of pregnancy, leading to live births. There is an urgent need to develop a quantitative and a reliable non‐invasive approach aiding embryo selection for elective single embryo transfer and to minimize recurrent pregnancy loss and multiple pregnancies. In this article, we provide a comprehensive review on our current knowledge and understanding of potential embryo‐derived molecular regulators, that is, biomarkers, of development of human blastocysts, their hatching and implantation. We discuss their potential implications in the assessment of blastocyst implantation potential and pregnancy outcome in terms of live births in humans.


Naturalists and Phenomenologists have contrasting conceptions of philosophy and its purpose. The naturalist takes philosophy to be a discipline that is continuous with the natural sciences, while phenomenology defines itself by its opposition to such a view of philosophy. My thesis project argues that this opposition is unfounded. The phenomenologist takes the world we consciously experience to be a world of subjective facts. My thesis begins by introducing the phenomenologist's conception of a subjective fact. I call a situation "a subjective fact" when it essentially involves a subject of experience. I go on to explain why phenomenologists thought the world we experience is a world of subjective facts. Naturalists hold that all facts are objective facts, and it is generally supposed that no fact can be both subjective and objective. I argue that it is the contrast between these two kinds of facts that led phenomenologists to conclude that a naturalistic theory of mind will have no place in it for subjective facts. A central claim in my PhD thesis is that a fact can be both subjective and objective. I argue that a naturalist could accept the existence of subjective facts if s/he could admit the existence of situations that essentially involve relations to subjects of experience. If a naturalist is to accept the existence of situations of this kind, a naturalist account must be given of what it is to be a subject of experience. A creature becomes a subject of experience, I claim, when it tokens representations with reflexive content. I offer an account of what it is for a representation to have reflexive content in terms of a special kind of representation I call 'an implicit self-representation'. I offer a naturalist account of implicit self-representation by appealing to the role this notion of representations plays in embodied and situated accounts of perception. I conclude that naturalism can admit into its ontology subjects of experience. The phenomenologist says naturalism must exclude subjective facts with the result that our relation to the world gets misdescribed. I argue that naturalists can admit subjective facts, thereby opening up the possibility of a naturalised phenomenology.


The CMS Submission Infrastructure Global Pool, built on Glidein-WMS andHTCondor, is a worldwide distributed dynamic pool responsible for the allocation of resources for all CMS computing workloads. Matching the continuously increasing demand for computing resources by CMS requires the anticipated assessment of its scalability limitations. In addition, the Global Plmust be able to expand in a more heterogeneous environment, in terms of resource provisioning (combining Grid, HPC and Cloud) and workload submissi.A dedicated testbed has been set up to simulate such conditions with the purpose of finding potential bottlenecks in the software or its configuration. This report provides a thorough description of the various scalabilitydimensions in size and complexity that are being explored for the future Global Pool, along with the analysis and solutions to the limitations proposed with the support of the GlideinWMS and HTCondor developer teams.


Objective To understand the community-school environment for walking around the road, to provide interventions for school-age child walking safety on the community. Methods In January 2009, 3 districts were randomly selected in downtown, another 3 districts in suburb separately. Then, a community was randomly selected in each district. A survey on the road traffic walking environment around the field was conducted in 42 primary and secondary school of these 6 communities. Results About 28.6% of the school gates within 100 meters had no traffic sign "Caution! School ahead", 76.8% of the schools entrance crosswalk lines didn' t set traffic lights. Over 45% of motor vehicles were at average speed of 20-40 km/h when they passing schools. At peak time of going to or leaving school, over 70% of schools had phenomenon that parents block up the road leading to sight obstruction across the street, over 60% of schools had phenomenon that vehicles block up or pedestrian no priority, over 50% of schools had no traffic police or assistant around cross walk. Conclusion Multi-section cooperation should be strengthened to improve the road traffic environment around schools and enforce efforts for children to create a safe and barrier-free pedestrian walking environment.


Financial managers, auditors, and fraud examiners are eager to find an automated, timely approach to discovering which publicly traded companies may be harboring financial frauds. Investors, corporate treasurers, and portfolio managers all want a dependable, automatic process to help them sift through voluminous financial data to find the few firms among hundreds that give investors bad information. Sadly, recent history includes many seemingly attractive investment opportunities that became worthless once fraud was discovered.


The purpose of this study was to: (1) analyze the effect of compensation on performance and job satisfaction of employees on the CV.Bio Karya Ite Curup City Rejang Lebong District Bengkulu Province. (2) to analyze the effect of job performance on job satisfaction of employees on the CV.Bio Karya Ite Curup City Rejang Lebong District Bengkulu Province. (3) analyze the effect of compensation on employees job satisfaction on the CV.Bio Karya Ite Curup City Rejang Lebong District Bengkulu Province. The method used in this study is a quantitative method. These results indicate that the performance and the compensation provide a positive and significant effect on job satisfaction of employees at work CV.Bio Ite Curup City Rejang Lebong District Bengkulu Province


The fungus Fusarium verticillioides produces fumonisins (FB1 and FB2), characterized by being the most frequently produced molecular forms and with greater toxicity. Fumonisin contamination is responsible for substantial losses during the meat production chain, so the safe levels of these compounds must be determined. The study was directed to establish safe levels of FB1 in poultry production; for this purpose, were used COBB 500® birds on experimental lots of infected corn during the 2015/2016 season in Brazil. The experimental group included 160 animals, divided into two groups: The T1 without fumonisin in the diet (control); and the T2 group in which corn was contaminated with 2.78 μg/g of fumonisin FB1. Histopathological effects of liver, heart, and small intestine, and zootechnical parameters were measured in birds treated. We found that there were no significant differences between the birds treated and untreated after 21 days of exposure to each treatment; F-values > P-values (P<0,05) for feed intake and weekly weight gain. Taken together, our data showed that the concentration evaluated is safe in poultry and will contribute to the design of future clinical studies.


To improve angiogenesis and restoration of blood flow in diabetic mice subjected to hind limb ischemia, here we test the hypothesis that Sanguinate (PEG‐COHb), which resides in the plasma and increases the efficiency of oxygen transfer, promotes these improvements. Wild type C57BL/6 mice at age 6 weeks were rendered diabetic with streptozotocin (stz) and at age 12 weeks were subjected to femoral artery (FA) ligation followed by administration of PEG‐COHb (20 ml/kg/day) via intraperitoneal (IP) injection daily for 4 weeks. Vehicle treated diabetic mice received IP injection with equal volumes of 1xPBS daily. Diabetic mice treated with PEG‐COHb displayed significantly improved blood flow ratios (ischemia/sham) by laser Doppler analysis on day 28 after FA ligation compared to vehicle treated group (63.36 ± 5.83 vs 44.39 ± 4.13 BFR (%), n≥9, p=0.019). Immunohistochemistry with anti‐CD31 IgG demonstrated significantly increased microvessel density in the muscle tissue of diabetic mice treated with SanguinateTM on day 28 after FA ligation compared to vehicle treated group (663.86 ± 57.78 vs 461.44 ± 36.19 capillaries/mm2, p<0.0001). Taken together, these data reveal significant therapeutic effects of SanguinateTM in diabetic limb ischemia in a murine model and may provide the basis for the use of this agent as complementary vascular‐salvaging therapy in long‐standing diabetes.


In this paper,a modified Tikhonov regularization CT image reconstruction algorithm from limited-angle was proposed.The modified Tikhonov regularization method adopted homotopy mapping to adjust the regularization parameter continuously,which increased the efficiency of computation procedure by avoiding the attempt of the regularization parameter.Experimental results show that the proposed algorithm improved the quality of reconstruction image by fixing on the optimization parameter rapidly.


The evaluation of flexible manufacturing system(FMS) is regarded as a multiple attribute group decisionmaking problem and has a critical impact on the improvement of manufacturing system competitiveness. Therefore, an effective group decision-making model using fuzzy-TOPSIS method is developed for the evaluation of alternative FMSs where the information available is subjective and imprecise. Initially, the voting method is integrated into the group decision-making model to obtain the appropriate attribute weights by aggregating fuzzy linguistic preferences of a group of experts. Next, the fuzzy-TOPSIS method is employed to determine the final ranking order of alternative FMSs. Finally, an empirical study is conducted to illustrate the applicability and potentiality of the proposed group decision-making framework. In addition, a sensitivity analysis is performed to demonstrate the robustness of the proposed model. Key–Words: flexible manufacturing system, group decision-making model, the voting method, fuzzy-TOPSIS, sensitivity analysis


— In this relatively informal discussion-paper we summarise issues in the domains of safety and security in machine learning that will affect industry sectors in the next five to ten years. Various products using neural network classification, most often in vision related applications but also in predictive maintenance, have been researched and applied in real-world applications in recent years. Nevertheless, reports of underlying problems in both safety and security related domains, for instance adversarial attacks have unsettled early adopters and are threatening to hinder wider scale adoption of this technology. The problem for real-world applicability lies in being able to assess the risk of applying these technologies. In this discussion-paper we describe the process of arriving at a machine-learnt neural network classifier pointing out safety and security vulnerabilities in that workflow, citing relevant research where appropriate.


The Center for Demographic, Urban and Environmental Studies of El Colegio de Mexico paid tribute to Julieta Quilodran for her outstanding work in teaching and research in the field of demography for over four decades. Speakers at the tribute emphasized her outstanding performance as a professor and researcher in demographic analysis. Mention was also made of the fact that Julieta Quilodran is a pioneer in research on family and marriage. She has spent forty years researching the transformations in marriage, families and fertility in Mexico and Latin America and is a worldwide reference in demography. She has also trained several generations of demographers, in whom she has instilled the value of the rigorous use of all the methodologies in demographic analysis.  Parejas conyugales en transformacion –which Julieta Quilodran compiled–, was also presented. This book documents the changes that have occurred from a demographic point of view in the sphere of marital and family life using various quantitative, qualitative and legal methodological approaches.  The tribute and the book presentation were held on April 23 at El Colegio de Mexico. Teresa Castro, Robert McCaa, Beatriz Figueroa, Viridiana Sosa, Manuel Ordorica and Silvia Giorguli participated in the ceremony. Lastly, Julieta Quilodran gave a brief message of thanks. The speeches of those who participated in the event, preceded by an introduction by Silvia Giorguli, director of the Center for Demographic, Urban and Environmental Studies of El Colegio de Mexico are given below.


Feasibility of repassivation potential, ER, as a crevice corrosion characteristic has been studied for the stainless steel/barnacle-crevice which is well known to cause corrosion problems in marine environment. Specimens of Type 316 steels were exposed to live sea water from June, July and August in 1982 for 1 to 5 months to deposit barnacles of various growth stages on specimen surfaces. ER measurements were conducted in the laboratory keeping the barnacles alive. Two types of specimens were utilized. The type M specimen has as many barnacles as deposited. The type S specimen has single barnacle left alone on its surface. The ER values obtained did not depend on maximum penetration depth as an extent of preceding growth of crevice corrosion. Various conditions of barnacles in size of bottom shell diameter, the starting month and duration of exposure in sea seemed to give minor influences to ER values. These facts confirm that the concept of ER as a well defined characteristic can be applied also to Type 316 steel/barnacle-crevice. The least noble ER value for the crevice is -0.3~-0.2V. SCE and less noble than +0.4V. SCE as the spontaneous potential of passivated stainless steel in live sea water. This does not extrude the


Isokinetic exercise is the most effective way for rehabilitation and muscle strength enhancement which needs the isokinetic dynamometer to provide the equipment support. As a human-machine cooperative equipment, stability and robustness performances are significant for motor controller. In this paper, brushless dc motor (BLDCM) system is discussed and its mathematical model is built. Fuzzy PID controller which includes conventional proportional-integral-derivative (PID) controller and fuzzy controller becomes an effective and self-tuning controller to realize isokinetic control under the irregular load torque. The model of BLDCM and fuzzy PID controller are built in the environment of MATLAB/Simulink to verify the response of the whole system. Reference speed and load torque are the input parameters and the result showed that the designed BLDCM controller is effective and stabilized under disturbance.


Abstract The aim of this research on questions and interrogative sentences in theoretical scientific texts has been, alongside with an analysis of their function, to confirm their explicit (non)occurrence. In order to achieve the intended aim, the research was based on a textual corpus representing present-day Czech academic monological discourse, involving a strict selection of various genres and scientific contents. The corpus includes team and authorial monographs, which are thematically divided into five fields: technical sciences (1); sciences of inanimate nature (2); medical and biological sciences (3); humanities and social sciences (4); agricultural and biological-environmental sciences (5). Despite their low frequency, interrogative sentences regularly occur in theoretical discourse, mostly as 'false' questions, both yes/no and wh-question types. In humanities and social sciences thus in contemporary scientific discourse, questions and interrogative sentences are used to dynamise the emotional neutrality and rigidity of technical exposition, enhancing the textual interactivity, or activating the recipient. Therefore, the occurrence of explicitly formulated questions is rather sporadic and, as a stylistic or rhetorical tool, they are more frequently used employed in popular scientific style.


This study was adopted to investigate the removal of Cr(III)and other physicochemical parameters of chrome tan wastewater. For this purpose, three precipitating agents, CaCO3, NaHCO3, and MgO, were used to treat chrome tan wastewater. After treatment, it was found, in three different dose trials, that each agent removed almost 97-99.5 % of chromium. At the same time, it was observed that with the increase of doses, removal percentage of TDS, conductivity, and turbidity of effluent were reduced. In the case of NaHCO3 and CaCO3, Cr(III) removal percentage at optimum pH was found to be 99.97% and 99.95% respectively, whereas the maximum removal percentage for MgO was found to be 99.98%. The NaHCO3 and CaCO3 were found to be comparable to MgO for Cr(III) removal from chrome tan wastewater. The recovered chromium concentration in the sludge for NaHCO3 and CaCO3 were also similar to that of MgO. This research suggests that these two precipitating agents can be used in the same way as MgO, for Cr removal and recovery treatments. Moreover, this recovered chromium can be reused, thus reducing the environmental pollution.


Abstract : An analysis of the current state-of-the-art of intensity-modulated fiber-optic sensors is performed. The dominant types of intensity-modulated fiber senors are outlined. The principles of operation are detailed and a description of the performance potentials and limitations are described. Trends in development and application areas are depicted.


Many studies show that there is a relation between personality disorder and substance dependency. Personality traits, especially antisocial behavior, may increase individual tendency towards using ...


"Reorganization" in accordance with the current Russian legislation is understood as such a significant change in a legal entity that falls under the five named in Art. 57 of the Civil Code of the Russian Federation forms (merger, accession, division, spin-off of a legal entity, transformation). The goals of reorganization in the normal (ordinary) conditions of the activity of a legal entity may be different (expanding the territory or areas of activity, optimizing the management structure, etc.). In the current conditions - the introduction of large-scale restrictive measures (sanctions) by foreign states and international organizations against Russian legal entities - the state also turned to the use of reorganization to form certain measures of influence (counteraction) on such restrictive measures, based on the fact that their introduction puts Russian legal entities in a disadvantageous position compared to competitors from unfriendly states, since it deprives them of the opportunity to access their property located (recorded) in foreign states. This problem was especially acute for Russian credit institutions, whose assets were "frozen" as a result of the introduction of restrictive measures. To overcome the negative consequences of this, a special decision was made - the possibility of reorganizing a credit institution in the form of a spin-off of a Russian legal entity from it, to which the assets of the credit institution, to which access is restricted, can be transferred (Federal Law No. 292-FZ of July 14, 2022 "On amendments to certain legislative acts of the Russian Federation, invalidation of paragraph six of part one of Article 7 of the Law of the Russian Federation "On State Secrets", suspension of the operation of certain provisions of legislative acts of the Russian Federation and on the establishment of specific features of the regulation of corporate relations in 2022 and 2023"). The content of this Law, its differences from the norms that regulate reorganization in ordinary conditions, became the subject of analysis for the author of this article. The author shows which legal decisions are insufficiently developed from a legal and technical point of view, and which decisions can (and should) "move" over time from the category of extraordinary to ordinary


The present invention discloses a MSTP optical transport networks and the backbone service transmission method and apparatus convergence point, to solve the problem in the conventional optical transmission network MSTP poor convergence service scheduling capability between the rings, to enhance convergence service transmission between ring effectiveness. The convergence layer MSTP optical transport network comprises: a plurality of converging rings, each ring MSTP converging annular passage in series into the backbone comprises two convergence point and the convergence point of several, and the convergence point of the two backbone by several convergence point ; each of rings a convergence point of convergence of the at least one key is shared by at least two converging rings. The present invention also discloses a method of service transport MSTP optical transport network, to solve the waste problem of the conventional path resource MSTP MSTP optical transport network, improve the transmission efficiency of the traffic aggregation ring.


Introduction: In this study, for the first time in children a polymer clip and endoloop (EL) for securing an appendiceal stump have been prospectively correlated and evaluated radiologically. Methods: Forty-nine patients aged 1 to 15 years were operated upon by the same surgeon for acute or perforated appendicitis between May 2008 and May 2009. The appendiceal stump was ligated by an EL or polymer clip. Patients were radiologically evaluated during the postoperative period. Results: In the EL group, the mean operating time for perforated appendicitis was recorded as 57.40 minutes and in nonperforated appendicitis as 39.37 minutes, respectively. In the clips-applied group, these periods were 48.23 and 34.72 minutes, respectively. Clip application is 3 times cheaper than EL. Conclusions: Polymer clip is an instrument that is cheaper, safe, easily applicable, and takes less time for securing appendiceal stumps compared with EL.


This introduction ' to research in nursing is designed to help nurses and students read, understand and evaluate research. The main contents are an overview of the research process; but ethics, dissemination and evaluation are included. There is a useful list of research sources, a glossary and a critical evaluation checklist. The further reading list should correct any problems caused by a few rather misleading statements.


A Cambodian Child with Developmental Disabilities and the Western Health and welfare Systen By Lisa Ann McPherson Ponce A.B. (Stanford University) 1980 THESIS Submitted in partial satisfaction of the requirements for the degree of MASTER OF SCIENCE in Health and Medical Sciences in the GRADUATE DIVISION of the UNIVERSITY OF CALIFORNIA, BERKELEY q;eEf Approved: . . . . ..(:::;;}TT7;;;!f??7FE3....5:??%?{?%§$. Chairman Date . . . . . . - . . - . . - a o . n o - . - . . . . . . - . . . . . . . . . . . . . . . . . .


The advanced regional E-grid η-coordinates model(AREM) is used to simulate the persistent heavy rain in South China during the period of June 20 to 22,2005,which caused a historical flood,and the AREM-simulated precipitation sensitivities to initial and boundary fields are tested.Results show that there are obvious differences between initial and boundary conditions' impact on simulated precipitation in the different time periods of simulation.The larger the initial disturbance error is,the larger is the model error.The experiments also reveal that forecast error firstly rapidly grows in the meso-and small scale systems accompanied with unstable moist convection process,then propagates to large scale ones.Because of the gradual release of convective available potential energy,the atmospheric instability reduces,and the error grows slowly in the large scale system.However,in the case that the initial and boundary fields are of the same precision,it is better to add the boundary mesoscale information,especially below 400 km,rather than to add the initial mesoscale information for effectively suppressing the growth of errors.


Autonomous robots are intelligent machines capable of performing tasks by themselves without human control. In this work, an autonomous robot that can navigate an indoor restaurant setting and assume the role of an automated customer servicing system is proposed. The robot has to be aware of its own position in the workspace and compute the shortest path to the customer when introduced in a known environment. The RRT path planning algorithm is optimized using goal biasing and vector field RRT is built upon it to reduce the total number of computations required, eventually reducing the latency. We closely model a real time restaurant environment where multiple customers request for service simultaneously or at random instants of time. The servicing robot has to prioritize requests based on different parameters such as distance-to-goal, number of obstacles in the path, frequency of calls made by the customer and other special concession for customers based on their age etc. and appropriately service the table with highest priority. The performance analysis of the proposed algorithm is compared with RRT based routing and it is observed that there is significant reduction in servicing time when the proposed model is implemented. Keyword – Path Planning, Localization, Navigation, Autonomous, RRT.


Abstrcat The prestressed reinforced concrete structure during construction is a time-dep endent structural system. The loads acting on the structure include con struction load and prestressed equivalent loads. Because of lacking of theory, t he errors usually appear in the design and construction of the structure. For ex ample, one real engineering is a prestressed reinforced concrete structure, and two sets of prestressed steel bar are designed, one comes through the strip of p ost pouring concrete and the other don't, moreover abnormal deformation is produ ced in construction of the structure. Therefore a continuum beam with elastic se at coming from the restrict of steel bar in a strip of post pouring concrete is proposed, considering the construction loads and prestressed equivalent loads, f urthermore causes of abnormal deformation are analyzed. The parameters of ancho r angle of prestressed steel bar and stiffness of elastic seat, etc. are studie d, then the suggestions for design and construction of prestressed concrete str uctures with a strip of post pouring concrete are given.


[Objective] To investigate the association of the genetic polymorphisms of rennin-angiotensin system and the risk of premature coronary artery disease(CAD).[Methods] By using PCR and PCR-restriction fragment length polymorphism,insertion/deletion polymorphisms of angiotensin-converting enzyme(ACEI/D) gene and polymorphisms of angiotensinogen(AGT) gene were analyzed in 111 patients,46 patients in premature CAD group,65 patients in mature CAD group and 50 in control subjects group.[Results] ACE-DD genotype was more frequent in premature CAD groups than that control subjects group(P0.05).ACE-DD genotype was not significantly different in mature CAD groups than that control subjects group(P0.05).ACE-DD genotype was not significantly different in total CAD groups(including premature and mature CAD groups).than that control subjects group(P0.05)The analysis revealed that the frequency of AGT-M235T is significantly higher in premature and mature CAD groups than in control subjects(P=0.039 and P=(0.047).)The combining analysis improved that AGT-TT and ACE-DD genotypes were significantly higher frequency in premature CAD group and mature CAD group compared with control group(P=0.006 and P=(0.031).) [Conclusion] The distribution of ACE-DD genotype and AGT-M235T genotype associates with premature CAD,and the combined analysis of AGT-TT with ACE-DD allele has a synergistic effect on risk of CAD.


This paper studied regularities of spatio-temporal distribution over the Dongjiang River Basin from 1951 to 1988.It was found that the spatio-temporal distribution of the mean of maximum half-hour rainfall is similar to the mean of precipitation′s,considering that climate and landform are the significant influencing factors to the spatio-temporal distribution of the mean of maximum half-hour rainfall.And it was also found that the maximum half-hour rainfall over the basin showed the significant increasing trend in the period from 1951 to 1988,there was a structural change of distribution in a year of maximum half-hour rainfall after 1971.


A review is made of the present status concerning the production of hot nuclei above 5 MeV temperature, concentrating mainly on the possible experimental evidences for the attainment of a critical temperature, on the existence of dynamical limitations to the energy deposition and on the experimental signatures for the formation of hot spinning nuclei. The data strongly suggest a nuclear disassembly in collisions involving very heavy ions at moderate incident velocities. Furthermore, hot nuclei seem to be quite stable against rotation on a short time scale.


A micro-hollow cathode discharge (MHCD) operated in Ar/N2 gas mixture, working in the normal regime, was studied both experimentally and with a 0D (volume-averaged) model in this work. This source provides high electron densities (up to 1015 cm−3) at low injected power (1 W). To understand the mechanisms leading to the production of N atoms, the densities of electrons, N atoms and argon metastable atoms (Ar*) were monitored over a wide range of experimental conditions. Electrons, N atoms and Ar* densities were probed by means of optical emission spectroscopy, vacuum ultra violet Fourier transform spectroscopy and tunable diode laser absorption spectroscopy, respectively. Measurements showed that using a smaller hole diameter enables to work with less injected power, while increasing the power density inside the hole and, subsequently, increasing the densities of excited species. Varying the percentage of N2 in the gas mixture highlighted that, up to 80%, the density of N atoms increases although the dissociation rate drops. Looking at the processes involved in the production of N atoms with the help of the 0D model, we found that at very low N2 fraction, N atoms are mostly produced through dissociative electron-ion recombination. However, adding more N2 decreases drastically the electron density. The density of N atoms does not drop thanks to the contribution of Ar* atoms, which are the main species dissociating N2 between 5% and 55% of N2 in the gas mixture. A reasonable agreement is found between the experiments and the model results. This study shows that, with this MHCD, it is possible to significantly modify the production of N atoms when modifying the physical parameters, making it particularly relevant for applications requiring a N atoms source, such as nitride deposition.


To express the omp31 gene of Brucella in E.coli and identify the antigenicity of the recombinant protein omp31 of Brucella.The omp31 gene were got from Brucella melitensis isolated in inner mongolia by polymerase chain reaction(PCR) and cloned into pMD18-T.After sequencing,the omp31 gene were cloned into vector pET-30a and expressed in E.coli BL21(DE3),then detected by SDS-PAGE and Western-blot.The results showed that the recombinant plasmid pET-30a-omp31 was constructed and expressed successfully in E.coli.It indicates that the recombinant protein can react with Brucella melitensis positive serum,it provides a good foundation for the study of laboratory diagnosis and preparation of the vaccine.


For pt.III see ibid., vol.16, p.L433-6 (1983). The variety of approximations used in estimation of the wavelengths of 1s2s 3S-1s2p 3P lines studied in this series reveals the need for a status report. Two new features are discussed: the need for basis set extrapolation at the low-Z end of the isoelectronic sequence, and an estimate of two-body corrections to the electron self-energy. The recommended theoretical values lie mostly within experimental error estimates for Z<10. For higher values of Z the authors propose to change to the values given in the second paper (1983) of this series.


Influencing and interweaving three multifarious architectural domains – moderated modernity postulations, urban-social issues and practicing experimental contemporary design – these were Milan Lojanica's calling-for-a-solution-frames in his opening professional decade (1962–1972), as they shape a composite subject matter of the research presented in this article. Beginning with the graduation project (1962), poetically, yet modernist oriented, throughout his first leading assignment in 1965, the young architect faced the unfavorable reality of Belgrade's substandard housing fund, thus both these experiences complemented and permeated each other – bearing a fruit of Julino brdo settlement, the winning competition project (1966/1967). Nevertheless, all these engagements ensured an introduction to the next, higher level of contribution, the ultimate city modernization with the design of a whole new structure area for the Polish capital.


For patients with metastatic clear cell renal cell carcinoma (mccRCC), administering a sequential, second-line tyrosine kinase inhibitor (TKI) may be more beneficial over a mammalian target of rapamycin inhibitor (mTORi).


This paper introduces the composition and working principle of flywheel energy storage system, and summarizes the charging control strategy of flywheel energy storage System. Among them, the control strategy of flywheel energy storage system of charging operation is divided into vector control strategy, compound control strategy and intelligent control strategy. On this basis, the characteristics of the charging operation control strategy of flywheel energy storage system and the problems existing in control operation are analyzed, and finally the summarization and prospect are made.


A unique phenomenon in the retailer market nowadays, where some of the retailers (salvage retailers) buy nearly expired grocery products from other retailers and resell them, may lead to the better market segmentation and increase the utilities of both consumer and retailers. This paper aims to model the possible relationship (i.e., decentralized and centralized system) between retailer and salvage retailer. EOQ model with demand as a multivariate function of product price, freshness level, and displayed inventory level is used. Zero ending inventory assumption inventory is also relaxed to boost the sale and profit based on the demand formulation. As a result, the objective is to determine three decision variables (i.e., product price, inventory cycle time, and ending inventory level) in order to maximize the total profit. Numerical examples are presented to highlight the theoretical implications and managerial insight.


This paper is an inquiry on the relationship between the human ability to share others' feelings thanks to a mechanism of simulation and one of the functions of rhetoric: maintaining social cohesion through epideictic speeches. As a starting point of this inquiry, we go back to Aristotle's concept of synaesthesia (from the ancient Greek syn =together and aisthesis =sensation). We then clarify the extent to which this concept can be used to provide a naturalistic account of the feeling of concord that the orator intends to create through praise and blame


To evaluate biochemical abnormalities and their association with the outcome of hospitalized coronavirus disease 2019 (COVID‐19) patients at a tertiary referral center in Iran.


Cover: The structure of the N-terminal thioredoxin domain of human glutaredoxin Grx3 solved by NMR spectroscopy. Abstract This thesis focuses on protein structure, dynamics and interaction and their relation to human disease. In particular, the biophysical and structural properties of both well-ordered and partially disordered proteins are studied using a range of biophysical techniques such as circular dichroism spectroscopy, fluorescence spectroscopy, mass spectrometry and nuclear magnetic resonance spectroscopy. Pseudomonas aeruginosa is a human pathogen due to its multidrug resistance (MDR) caused by overexpression of efflux pump systems. This thesis describes how MDR mutations within the MexR repressor of the MexAB-OprM system reduce the DNA affinity by altering its stability with maintained structure. The oncogenic protein c-Myc is involved in many essential biological functions such as cell proliferation, differentiation and apoptosis and is also highly associated with several forms of human cancers, and where the N-terminal domain is regulated by a plethora of protein interactions. In this thesis the intrinsically disordered N-terminal part of c-Myc and its interactions with the proteins Bin1 and TBP are described. Myc binds Bin1 with maintained disorder in a multivalent manner, which may explain why the onco-protein can interact with such a wide range of binding partners. A similarly dynamic interaction is observed for Myc with the TATA-binding protein (TBP). The essential human multidomain glutaredoxin Grx3 is associated with several biological functions such as redox signaling, proliferation and signal transduction. We have solved the structure and analyzed the dynamic properties in the ps-ns and ms time scale for the two N-terminal domains, providing a platform for further analysis of the Grx3 protein and its interactions. Taken together, this thesis emphasizes the importance of joint structural, biophysical and dynamic studies to better understand protein function in health and disease. List of publications This thesis is based on the following papers, which are referred to in the text by their Roman numerals (I-V). properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance " " Transient structure and intrinsic disorder in the c-Myc transactivation domain and its effects on ligand binding " Submitted III Molecular characterization of the interaction between the disordered c-Myc transactivation domain and the TATA-binding protein (TBP) " Manuscript IV and dynamic analysis of human glutaredoxin 3 " Manuscript A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase " " Proteolytic cleavage …


Using solar radiation to fuel catalytic processes is often regarded as the solution to our energy needs. However, developing effective photocatalysts active under visible light has proven to be difficult, often due to toxicity, instability, and high cost of suitable catalysts. We engineered a novel photoactive nanomaterial obtained by the spontaneous electrostatic coupling of carbon nanodots with [P2W18O62]6- , a molecular catalyst belonging to the class of polyoxometalates. While the former are used as photosensitizers, the latter was chosen for its ability to catalyze reductive reactions such as dye decomposition and water-splitting. We find the electron transfer within the nanohybrid to be so efficient that a charge-separated state is formed within 120 femtoseconds from photon absorption. These results are a cornerstone towards the engineering of a new class of nano-devices, non-toxic, low-cost, and able to carry out solar-driven catalytic processes.


This article focuses on special education in New Orleans post Hurricane Katrina. After Hurricane Katrina, Louisiana's Recovery School District (RSD) took over 102 of the city's 128 schools with the stated goal of creating a 'choice district' for parents. This 'choice district' is made up of RSD direct-run schools, Orleans Parish School Board (OPSB) schools, 'open-admissions' charter schools and selective-admissions charter schools. Obtaining entrance into the more selective schools that succeed academically has become a survival-of-the-fittest contest, as special education students are often concentrated in certain schools. This is because of entrance requirements, enrollment caps and the RSD's hands-off approach with discipline proceedings. This article first reviews the legal precedents for special education and then discusses the application of these laws in the decentralized school system within New Orleans. The article was written by a former teacher in the RSD.


Individuals with T1D are generally advised to reduce basal rates and increase CHO intake during aerobic exercise. We assessed the effects of a different insulin regimen guided by rtCGM data on CHO intake and glucose levels in 17 T1D adults treated with insulin pumps (11 male, 42±8.8 years, 24±10 years DM duration, 6.6±0.8% A1C) vs. traditional insulin adjustment guidance during 2 consecutive days of extended biking activities (30 miles [49 km]). On day 1 (D1), subjects reduced their basal rate by 50% and consumed CHO as guided by their rtCGM (Dexcom G6) data to maintain target range (70-180 mg/dL). Basal insulin infusion was stopped 1 hour at the start of the day 2 activity (D2) then resumed at a minimal rate (0.23±0,1U/hour) during biking. All CHO from 1 hour before, during and 10 min after the activity was recorded. Times within/below target range, glycemic variability (GV) and mean glucose were calculated from rtCGM data. CHO intake was notably lower during D2 vs. D1 (36±32 vs. 40±27 g, p=NS), with slightly more time in range and Disclosure M. Mueller-Korbsch: Research Support; Self; Dexcom, Inc., Eli Lilly and Company, Insulet Corporation, Menarini Group, Novo Nordisk Inc. L. Fruhwald: None. M. Heer: None. M. Fangmeyer-Binder: None. D. Reinhart-Mikocki: None.


It is postulated that the increase in H₂O₂ formation following phagocytosis in guinea pig polymorphonuclear leukocytes is due to the activation of a plasma membrane located NAP(P)H oxidase. -- The cyanide-resistant oxidase activity of intact leukocytes was markedly stimulated when the leukocytes were suspended in a hypotonic medium. Hydrogen peroxide was the principal product of the oxidase reaction. Furthermore the oxidase was active enough to account for the respiratory burst that accompanies phagocytosis. Evidence that the oxidase activity was located on the outside surface of the plasma membrane was the finding that added NAD(P)H was rapidly oxidized and the plasma membrane was impermeable to NADH or NADPH. Further evidence was the marked inhibition of the oxidase by p-CMB which also did not penetrate the plasma membrane. The oxidase was also inhibited on disruption of the plasma membrane. In addition, the enhanced oxidase activity under hypotonic conditions decreased to normal values when the medium was made isotonic and suggested that a reversible conformational change in the plasma membrane was responsible for the activation of oxidase activities. -- Treatment of the leukocytes with digitonin at concentrations low enough so that the leukocytes were not disrupted caused a cyanide-resistant burst of oxygen consumption. Added cytochrome c was reduced and this reduction was blocked by superoxide-dismutase, indicating the formation of superoxide radicals by the leukocytes during the burst of oxygen consumption. -- The cyanide-resistant oxygen consumption of resting PMNs was also found to be stimulated by 2,4-dichlorophenol with H₂O₂ being the sole product formed. NADH and NADPH added to the leukocytes greatly enhanced the oxygen consumption and were oxidized in the process without penetrating the leukocytes. Mn²⁺ stimulated this oxidase activity. Purified peroxidases also had NAD(P)H oxidase activity with similar properties. The NADPH oxidase activity of polymorphonuclear leukocyte granules has not previously been attributed to myeloperoxidase because of its relative insensitivity to cyanide and its activation by aminotriazole. However, the NAD(P)H oxidase activity of myeloperoxidase or horseradish peroxidase was little affected by 2.0 mM cyanide although the peroxidase activity was nearly completely inhibited by 0.1 mM cyanide. Furthermore, the NAD(P)H oxidase activity of myeloperoxidase was considerably enhanced by aminotriazole although the peroxidase activity was inhibited. However, myeloperoxidase is not responsible for the oxidase activity of intact leukocytes as the peroxidase activity of intact leukocytes was very low and density gradient fractionation of the leukocytes showed that the NAD(P)H oxidase activity of the cytosol fraction had very low peroxidase activity.


Each year, 15,000 critically ill neonates require specialized care that is offered in only 32 tertiary neonatal intensive care units (NICUs) in Canada. Previous studies have shown associations between nurse-to-patient ratios and higher bed occupancy with patient outcomes.

 To explore neonatal managers' perceptions of organizational factors in Canadian NICUs.

 This was a web-based cross-sectional survey, consisting of 20 questions pertaining to the determinants of resource allocation, the ascertainment of high occupancy state, as well as the different challenges and mitigation strategies implemented during periods of high unit strain. The survey was designed following the CHERRIES guidelines and was critically reviewed through a two-round validation process prior to deployment. It was sent by e-mail to the unit managers of all Canadian Level-3 NICUs between August and November 2022. They were invited to respond based on their unit's practices in 2021. The analysis was conducted using descriptive statistics, where units were dichotomized by size (small unit ˂36 beds, large unit ≥36 beds).

 A total of 24 unit managers (75%) completed the survey. Most respondents relied exclusively on clinical judgment to estimate the total number of nurses required per shift (33%) and the individual nurse-to-patient ratios (67%) as opposed to nursing workload assessment tools (8% and 21%, respectively). The response for the proportion of nursing shifts perceived as adequately staffed was: 0% for 100% adequately staffed, 37% for ˃80% adequately staffed, and 27% for 60%-80% adequately staffed. The response for the proportion of nursing shifts perceived as understaffed to the point of being unsafe for patient care was: 17% for no understaffed, 52% for ˂20% understaffed, and 9% for 20%-40% understaffed. The most common organizational challenges were personnel recruitment and unit occupancy (each reported as being a major issue by 38% of respondents). Although most (75%) respondents believed that high occupancy, especially when exceeding 90%, likely increases the risk of adverse patient outcomes, they revealed implementing mitigation strategies to reduce occupancy only when it exceeded 95%. At that point, the most common strategies implemented were to call for additional voluntary nurses, implement voluntary nursing overtime, and accelerate patient transfer.

 Although Canadian NICUs form a very heterogeneous group, managers shared similar perspectives in terms of staffing and occupancy challenges. This emphasizes the need for collaborative NICU person-power resource management practices to improve neonatal intensive care service organization.


One of the great changes in the world situation after World War II was the long period of peace without war between democracies and even great powers. However, the world is not easy in the halo of peace. The smoke of local wars such as the Iraq war has not yet dissipated, and frequent terrorist groups is worrying. In Asia, Japan's military influence, which is second only to the United States, cannot be underestimated. Its defense strategy changes from specialized defense to outward defense. This situation brings a new threat to the security of all countries in the Asia-Pacific region. The problem of the "security dilemma" remains one of the major issues in international politics today. In this regard, realism puts forward the theory of potential equalization and deterrence, while liberalism puts forward the theory of world government, collective security, economic interdependence, and democratic peace. Among them, democratic peace theory, as a popular theory in the field of western international relations research, has aroused wide controversy in the academic circles. "Democratic peace theory" believes that there is no or little war between democratic countries, and "non-democratic countries" are the root cause of war, and expanding democracy is the inevitable requirement for maintaining peace. "Democratic peace theory" does not conform with historical facts, it is the theoretical basis for neo-interventionism in promoting human rights diplomacy. The relationship between democracy and peace is complex: peace between international society and international relations requires not only a domestic democracy, but also in international life; democracy is only one of the many reasons affecting international peace, It has limited impact on peace; the "democracy peace theory" advocates established peace is essentially local peace between western countries based on unreasonable international political and economic order, the consolidation of overall world peace and the establishment of just and reasonable new international order call for new democracy.


The use of literature research,video observation,and mathematical statistics method,the Chinese men's basketball team in the final of the 25th Asian Championships offense region statistical analysis.The results showed that:(1) center,forward,guard three positions with the Iranian team scores of athletes compared to the gap between guard and forward position is particularly evident;(2) center of regional players attack the basket no obvious advantage,forward the regional distribution of offensive players less in the long shot over the past cast;(3) guard,forward player technology is not full,the basket close score and score a breakthrough capability is weak.As soon as possible to improve guard,forward offensive capability,shorten the gap between the teams with the world.Chinese team must be targeted for scientific training to develop all-around players,efforts to improve regional imbalances,and a strong offensive against the ability to score under the weaker condition.


MANDELBROT enunciated the uncertainty of the length of a coastline in his paper"How long is the coastline of Britain?"published in "Science" in 1967. The fractal concept was presented for the first time in that paper and has been applied to many fields ever since. According to the fractal theory and conditions of fractal research of coastline,the controls of faults and biologic function on the fractal character of coastline are preliminarily discussed on the basis of GIS in this paper . Finally,some significant conclusions are drawn:1)the faults control the basic trends of coastlines of two study areas;2)the fractal dimension of coastline of Taiwan is smaller than that of Changle-Lufeng,because the faults of Taiwan more intensely control the trend and fractal dimension of the coastline;3)the larger the fractal dimension of the faults or the major faults,the more the controlling effect of them on the trend and fractal dimension of coastline; 4)the larger fractal dimension of the coastline of Changle-Lufeng indicates that the biologic function intensely shapes the coastline. In a word,the controls of faults and biologic function on the fractal character of coastline are discussed with a case study of China in this paper,it can be seen that faults and biologic function both have influence over the trend and fractal dimension of coastline,the fractal mechanism of coastline of two study areas may be so.


One of the criteria for a comfortable ecologically clean urban environment is access to green spaces, their number and quality in any given city. Public green spaces play an important socio-cultural role in the context of active and passive recreation of citizens, various types of recreational activities. The relevance of this study is due to increased attention to the formation of open public spaces in the city of Krasnoyarsk. The purpose of this work is to trace the evolution and identify the social and cultural significance of the green public spaces in Krasnoyarsk. The objectives of the research are to study the green spaces of Krasnoyarsk in a historical retrospective, analyze the green spaces of Krasnoyarsk from the point of view of their ecological significance, recreational use. Research methods included literature review on the topic, analysis of historical data, field survey of the territory, long-term observation, photographic recording, comparative retrospective analysis, and graphic-analytical method. The study captures the most common types of public green spaces and their role in creating a comfortable urban environment. It traces in the most detail the evolution and cultural significance of the most important historical green spaces in Krasnoyarsk: the City Garden (now the Central Park), Yudinsky Garden, Krutovsky Garden. These examples show that gardens and parks can be formed both on the basis of the natural environment of urban forests, and artificially created by the efforts of citizens, that over time they can undergo various quantitative and qualitative, planning and functional transformations. Despite the transformations that have taken place, all the studied historical objects still exist and are used for their intended purpose. In addition to these historical green areas, we examine the newly organized public green spaces with a cultural and recreational component over the past decades: Tatyshev Park, All-season Fun-Park Bobrovy Log, Flora and Fauna Park Roev Ruchey, Dream Gardens and others. The article notes the importance of municipal, public and private initiatives in the organization of local green areas. The analysis allows us to assert that there is a certain system of public green spaces in Krasnoyarsk. It has disadvantages, such as an uneven distribution of green areas throughout the city, lack of interconnections between individual elements, aging of certain areas of greenery, and the complete destruction of some. Nevertheless, the city authorities, architects, designers and the general public make great effort to create a green framework for Krasnoyarsk destined to have an important recreational and cultural role.


This commentary reflects on some common themes that are starting to emerge in the early analysis of the healthcare procurement and commissioning response to the COVID-19 pandemic. Although it largely results from the observation of the situation in the English NHS, the most salient issues are common to procurement in other EU healthcare systems, as well as more broadly across areas of the public sector that have strongly relied on the extremely urgent procurement exception in the aftermath of the first wave of the pandemic. Given the disfunction and abuse of 'unregulated procurement' in the context of COVID-19, the commentary reflects on the longer term need for suitable procurement rules to face impending challenges, such as Brexit and, more importantly, climate change.


Abstract : Several novel implementations of optical bistability have been proposed and analyzed. Novel applications of optical nonlinearities in a ring have been proposed; particularly interesting is the use of nonlinear nonreciprocity of counterpropagating waves in a ring to enahnce the Sagnac Effect, and, thereby, increase the sensitivity of a passive ring optical gyro. The use of moderate energy electron beams traversing superlattices to generate coherent x-rays by the coherent addition of transition radiation has also been proposed and analyzed. This document is a collection of articles pertaining to such fields as: Solitons; Cyclotron resonance of free electrons; High energy electron beams. (Author)


The work was aimed at studying the production of cells and metabolites of Bacillus subtilis (ACB-69) and of Trichoderma viride conidia (ACB-14) on different substrates, since they can potentially control Phyllosticta citricarpa. Our results showed that the medium consisting of cotton meal added of hydrolized protein provided the highest yield of B. subtilis cells (2.44 x 10 9 cells/mL), after the culture had been incubated for three days. This liquid substrate also provided conditions for the bacterium to produce thermostable metabolites, in sufficient amounts to inhibit the plant pathogen's micelial growth. The production of B. subtilis under the solid fermentation system performed better on the brewers rice substrate; the number of bacterial cells decreased as the substrate concentration increased. In general, the liquid medium yielded a higher amount of B. subtilis than the solid medium. With regard to the large scale production of T. viride, it was verified that the substrates tested had a low spore production; the best substrate among those tested (corn cob + hydrolized protein) only yielded 2.17 x 10 6 conidia/mL.


Ac78 of the archetype of the Baculoviridae, Autographa californica multiple nucleopolyhedrovirus( Ac MNPV),is a recently identified baculovirus core gene. It plays an important role in the baculovirus life cycle. An amino acid( aa) alignment of the Ac78 homologs showed that Ac78C-terminal aa 105 ~ 108 are highly conserved in group I NPVs. To investigate the role of Ac78 aa 105 ~108 in the baculovirus life cycle,an Ac78 gene truncated Ac MNPV recombinant( v Ac78: del105-108),in which the Ac78 cassette without residues 105 ~ 108,was constructed successfully with Bac-to-Bac system. To examine the effect on occlusion body morphogenesis and to facilitate examination of virus infection,the Ac MNPV polyhedrin( Polh) gene and the enhanced green fluorescence protein( Egfp;referred to as Gfp in the present study) gene whose expression was driven by its own promoter and theAc MNPV immediate-early gene Ie1 promoter,respectively,were also inserted into the recombinant virus.Fluorescence microscopy and titration assay demonstrated that Sf9 cells transfected with v Ac78: del105-108 or v Ac78: HA showed a normal and steady increase in virus production and similar virus growth kinetics. Electron microscopy showed that the cells transfected with v Ac78: del105-108 exhibited the typical characteristics of baculovirus infection,which were similar to those of v Ac78: HA-transfected cells. Immunofluorescence microscopy showed that,in the nuclei of v Ac78: del105-108-infected Sf9 cells,discrete foci of red fluorescence appeared near the inner nuclear membrane at 24 hour post infection( h p. i.),and they were condensed at 48 h p. i.,by 72 h p. i.,Ac78 was concentrated within the ring zone and formed larger foci. In summary,we provided the evidence demonstrating that removal of the Ac78 aa 105 ~ 108 did not affect the productions of budded virions and M-ODVs and the subcellular localization pattern of Ac78 in Sf9 cells. That is,Ac78 aa 105 ~ 108 is not essential for its role during the baculovirus life cycle.


ABSTRACT Jennifer Duncan and Sylvia McAphee exemplify career paths that differ from traditionally defined job descriptions and assigned responsibilities. In the course of their careers, both of these librarians have assumed simultaneous roles in Technical and Public Services departments. In this presentation, they challenge librarians working in traditional roles to embrace opportunities to serve in positions outside their assigned job descriptions in spite of barriers imposed by peer or administrative adherence to narrowly defined roles.


This project aims to make an implementation of an IP telephony solution targeted for small to medium enterprises, and has been implemented in a private institution. In the first chapter basics of telephony spans to better understand the setup and operation of the solution other than to make clear basis on issues that although not implemented in this project you can do on this platform as an improvement in the services it provides. Chapter two contains some important aspects in order to establish the viability of the project to be implemented, which allows having an appreciation of the reality of the situation and assessing the resources needed to meet objectives when considering the project settings….


Effect of heat treatment on microstructure, phase transformation temperature and shape memory effect of TiNi alloy fine wire has been studied by means of DSC, SEM and bending test. The results show that precipitates and phase transformation temperature increase with the increase of temperature and time. Shape memory strain of the specimen heat-treated at 500℃ for 30 min is biggest. Fatigue life of specimens shortens with the increase of bend strain. Fatigue life of specimen heat-treated at 500℃ is best.


The present invention is particularly sports field surfaces, to a method for determining the values of stiffness and damping. The present invention further relates to a device for implementing the method described above. An object of the present invention provides a highly reliable measurement results in a rapid and effective method is to provide a method and device for determining the stiffness and the value of attenuation of the lawn artificial. The device is easy to use, it is easily transported is. To achieve the above object, the method according to the invention, the block was placed on the surface, the block, at an adjustable frequency interval by using the electronically controlled exciter, the by the force sensor is hit with force, which is sensed as 1 signal, then the acceleration of the block is determined as the second signal using the acceleration sensor, then the frequency-dependent transfer function is determined using the above-mentioned signals, the from the function, stiffness and damping behavior that depends on the frequency of the surface it is being determined subsequently.


Aiming to cope with the nonlinear balance control problem, the predictive Feedback Error Learning (P-FEL) model was proposed. In the P-FEL model, both the state predictive signal and the output of the Conventional Feedback Controller (CFC) were integrated into the teacher signal of the Neural Network Feedforward Controller (NNFC). An on-line back-propagation (BP) algorithm with the self-adaptive learning rate was developed and employed in the NNFC to realize the combination of learning and controlling. Computer simulations on inverted pendulum balancing task demonstrate that the P-FEL model could effectively reduce the precision requirements of the CFC parameters, and guarantees good balance performance and acceptable robust performance.


This paper analyzes the problems existing in the process of implementing the objective system of the Chinese Communist Party construction in Guizhou's universities and colleges.Accordingly,guidelines for solution are proposed.


A DC-link decoupling circuit is provided in combination with two inverters which are connected in parallel to a common DC power supply line and each of which inverter driving one different traction motor, switch means being provided for each of said two inverters, for separating the corresponding inverter from said power supply line in case of failure. The said DC-link decoupling circuit is provided with resonance oscillation attenuating/damping means in the form of an RL filter (resistor-inductor filter). The invention relates also to an electric locomotive comprising at least two electric motors, each motor being controlled by one of two inverters, each of which inverters is powered by a common power supply line, switch means being provided for each of said two inverters, for separating the corresponding inverter from said power supply line in case of failure. DC-link decoupling means are provided for decoupling the resonance condition of inverters, which means consist of an RL filter having a damping inductor and a damping resistor in parallel.


The rare-earth metal, ytterbium (Yb), was deposited on graphene grown on Si-face SiC, kept at room temperature. Yb was not found to intercalate, destroy or dope the graphene layer before subsequent heating, unlike alkali metals such as Li and Na. Our photoemission results reveal that heating to 300˚C promotes Yb intercalation into the graphene-substrate interface. Real-time low energy electron microscopy (LEEM) measurements indicated intercalation to start at a sample temperature of around 220˚C. In the intercalation process, Yb penetrates through the graphene and buffer layer and forms bonds to the silicon in the topmost SiC substrate bilayer, as indicated by the shifted components observed in the C 1s, Si 2p, and Yb 4f spectra. The Yb intercalation decouples the buffer layer from the substrate and transforms it into another graphene layer as manifested by the absence of buffer layer spots in the µ-LEED pattern and the appearance of an additional π band in the ARPES spectra, respectively. Moreover, the observed shift of the Dirac point down from the Fermi level by 1.9 eV indicates electron doping of the graphene layer upon Yb intercalation. The Yb intercalated graphene sample was found to be thermodynamically stable up to temperatures around 700˚C.


Despite the clinical use of therapeutic transference across various schools of psychotherapy, there have been relatively few empirical studies of this phenomenon, none of which has examined transference with a non-pathological population. In this study, the core conflictual relationship theme (CCRT) method was used to examine the manifestation of therapeutic transference in the first three sessions of 22 counselling contracts with high-functioning individuals. Factor analyses of the wish (W) and response of other (RO) components of the CCRT indicate a complementary pattern of relating in which the therapist is idealised and others are devalued. Within the response of self (RS) component, clients exhibited a concordant relational transfer whereby they had a negative response to both the therapist and others. Additionally, control issues emerged in the W component for significant others and in the RS component for the therapist.


The present paper examines the correlation between extrinsic motivation, intrinsic motivation, and the emotional state flow experience on the basis of latest researches made by behavior scientists. The impacts of these parameters on the organizational performances are also discussed. Attempt have been made to develop an applicative motivational model that can be utilized by managers in order to generate intrinsic motivation and flow experience among the employees while they are involved in the organizational activities. Also various constraints have been identified that intimidating managers to put the efforts on generating intrinsic motivation and flow experience.


The invention discloses a method for producing HCl gas through chlorosilane residual liquor, and belongs to the field of recycling chlorosilane residual liquor in the polycrystalline silicon industry. The mode that a stirring reaction kettle and an absorption tower are connected for use is adopted, the chlorosilane residual liquor is hydrolyzed in the stirring reaction kettle, and after H2 and HCl gas generated through hydrolysis of the residual liquor and SiCl4, SiHCl3 and SiH2Cl2 volatile gas which is not reacted completely are fully absorbed by the absorption tower, more than 99% of chlorine is absorbed in the way of hydrogen chloride; tail gas is alkali-washed and then is discharged with the standard level; absorption liquid of the absorption tower enters the stirring reaction kettle to serve as a residual liquor hydrolysis reaction absorbing agent, the HCl gas generated by desorption of concentrated hydrochloric acid can return to the trichlorosilane synthesis process, desorbed diluted hydrochloric acid serves as the absorbing agent of the system, and therefore chlorine can be recycled. By the adoption of the method, chlorine in the chlorosilane residual liquor is effectively recycled, resource utilization is achieved, the quantity of chloride ions entering a follow-up sewage treatment device is reduced, and the treatment cost of factory sewage is lowered.


Quantification of intact serum immunoglobulins has proven useful in the evaluation of patients with suspected immunodeficiency disorders, lymphocyte and plasma cell neoplastic diseases, allergic conditions, and some chronic inflammatory and autoimmune disorders. Since the advent of quantitative immunoglobulin assays nearly 50 years ago (1), increasingly robust analytical methods have been developed. The armamentarium of intact immunoglobulin assays was first substantively expanded by the development of immunoglobulin light-chain measurements in which the light chains are bound to heavy chains (intact immunoglobulins). The last decade has seen the development of both free (unbound) immunoglobulin light-chain assays and heavy/light-chain (HLC) or junctional epitope assays, the latter of which allows for individual measurements of IgGκ, IgGλ, IgAκ, IgAλ, IgMκ, and IgMλ (2, 3). Despite these advances in immunoglobulin and light-chain quantification methods, there remain technical complexities that can influence accuracy and, in turn, proper clinical application. Equally important, even with robust assays, is the need for thorough understanding of the clinical indications for, and limitations to, immunoglobulin and related measurements.


In order to predict the soft soil foundation settlement and analyze economic cost management, the basic concepts of soil foundation settlement are discussed. A new prediction algorithm is proposed. The new prediction algorithm principles of numerical prediction are described based on the basic concept of contrary degree and Opposite Degree. Firstly, the relevant data is selected from engineering example; then, according to the contrary degree algorithm, the test set and prediction set are calculated based on Opposite Degree computation; finally, in order to evaluation experimental results, the prediction results compared with BP neural network algorithm and Opposite Degree algorithm. The results show that, Opposite Degree computation algorithm is an effective method for settlement prediction of soft soil foundation. At last, we analyzed the economic cost in soft soil foundation and put forward some management suggestions.


Purpose: The aim of this study was to investigate the clinical features and outcome of thyroid carcinoma in elderly patients, and to identify factors that influenced survival. Methods: Among 3,267 patients with thyroid carcinoma who were treated in the Department of Surgery at Yonsei University College of Medicine from March 1986 to March 2004, 53 patients were identified who were age 75 years or older at the time of diagnosis. The mean age was 78 years (range, 7590 years) and the mean follow-up was 37.6 months (range, 1096 months). Results: There were 41 female and 12 male patients. Forty eight tumors were well-differentiated carcinoma, 5 tumors were undifferentiated or anaplastic carcinoma. Twenty eight patients were in stage T4. Palpable lateral neck node and distant metastases were evident at presentation in 24 and 7 patients, respectively. Forty two patients were completely resected, and 11 patients were unresectable and underwent biopsy only. Of the 42 patients who were completely resected, 30 and 12 patients underwent total and less than total thyroidectomy, repectively. External radiotherapy was administered to 6 patients. The overall survival rate and disease specific survival rate were 49.8% and 51.0% at 5 years, respectively. Multivariate analysis showed that distant metastases and external radiotherapy were independent prognostic factors for survival. Conclusion: Thyroid carcinoma in patients aged 75 years or older appears to behave more aggressively. Therefore, an optimal therapeutic approach is recommended and should not be withheld on the basis of chronological age. If indicated, aggressive surgery should be necessary to improve survival.


nificance for the Civil War generation" and "likely served to insulate soldiers and their families from the horrors of the battlefield" (67). To be sure, this omission is far from a disqualifying infraction, and it seems likely that Schantz knew that Faust would handle this matter in greater detail. Indeed, she convincingly confirms the accuracy of his postulations, but it would have been nice if he could have included a few more examples to demonstrate the continuity between the antebellum mind-set and ideas expressed during the war. Furthermore, both books could have benefited from including the perspectives of ordinary American civilians rather than relying almost exclusively on the writings of elites. Although Faust incorporates the opinions of enlisted men and southern women, she would have profited from even the briefest foray into the letters and diaries of unrenowned northern citizens, which contain an abundance of material pertaining to death. Anyone who has browsed through the history section of a major bookstore chain will have come across This Republic of Suffering, and Awaiting the Heavenly Country deserves an equally wide reading. Specialists of nineteenth-century U.S. history and the Civil War will find these works to be essential for understanding how a generation of Americans confronted a culture pervaded by death. Scholars in other fields will gain insights that might shed light on man's universal struggle to come to terms with death throughout all eras and cultures. Nearly four hundred years ago, the English poet John Donne eloquently affirmed, "Any man's death diminishes me, because I am involved in Mankind." Although the Civil War generation would have concurred with this sentiment, they might have substituted "the nation" for "mankind." During the Civil War, families unquestionably mourned their blood relations and personal friends, yet the sheer volume of death ultimately shifted the emphasis away from the heroic sacrifice of an individual soldier and the grief of a particular family to the immeasurable worth of the nation that soldiers' collective deaths preserved for all citizens. These books confirm that nineteenth-century Americans, rather than being overwhelmed by death, effectively transformed their individual and collective losses into opportunities for personal improvement and national unity.


Histopathological changes of pretreatment bone marrow biopsy from 42 cases with acute myeloid leukemia (AML) were described. A considerable difference was shown between the results of aspirate smears and the findings of plastic embedded biopsy sections, particularly in bone marrow cellularity such as infiltration of inflammatory cells and presence of residual hemopoietic cells, qualitative and quantitative abnormalities of megakaryocytes suggestive of myelodysplastic features were more accurately assessed in the sections of marrow biopsy than in the aspirate smears. In three cases there was considerable infiltration of maturing but dysplastic granulocytic cells and erythroid precursors in the sections, but not in the aspirate smears. Our study shows that plastic embedded biopsy sections provide more information than aspiration smears for the diagnosis of AML.


A simple system for rough estimation of the occupancy of an ad-hoc organized parking lot is presented. A reasonably simple microprocessor hardware with a low resolution monochrome video camera observing the parking lot from the location high above the parking surface is capable of running the proposed 2-D separable discrete wavelet transform (DWT)-based algorithm, reporting the percentage of the observed parking area occupied by cars. A simple calibration is needed – the mask covering all the areas outside the parking lot must be prepared. The proposed system has been tested on the dedicated FPGA-based hardware in real conditions and proven immune to scene and light changes. As it is discussed in the paper, it can be used in low-power wireless sensor networks.


Review(s) of: Climate change and Australia: Warming to the global challenge, by Ben Saul, Steven Sherwood, Jane McAdam, Tim Stephens and James Slezak, Federation Press, 2012, 246 pp; $39.95 (paperback).


The invention discloses a method for preparing industrial tannin by using Chinese gall Beihua as raw material. The method comprises the following steps of: using water as the solvent for the Chinese gall Beihua raw material, controlling the liquid ratio to 1:5-8, controlling the leaching temperature to 50-80 DEG C, controlling the leaching time to 16-48 hours, slowly adding metal salt or hydroxide complexing agent accounting for 2-20% of raw material into the obtained Chinese gall Beihua tannin leaching liquid, stirring and reacting for 1-4 hours at the temperature of 20-60 DEG C, settling, and filtering to obtain tannate; adding water with the proportion of 1:4-8 to mix, adding acid accounting for 1-20% of raw material to uniformly stir, standing for 1-2 hours, desorbing metal ions, filtering to obtain the Chinese gall Beihua tannin liquid, and evaporating and drying to obtain powdery Chinese gall Beihua tannin. The invention for preparing industrial tannin by using Chinese gall Beihua as raw material can use the Chinese gall Beihua raw material with low cost to prepare industrial tannin products with the purity not less than 81%, the yield achieves about 26%, the process is simple, the cost is low, and the economic benefit is obvious.


Para testicular sarcomas are extremely rare, with only 110 cases reported in literature. The most common histological subtypes include liposarcoma, leiomyosarcoma (LMS) and rhabdomyosarcoma. LMS is thought to arise from para testicular smooth muscle tissues and they are prone for direct invasion and also early haematogenous spread. No established treatment protocol is so far established; however, general consensus comprises inguinal radical orchidectomy and high cord ligation, with some case series advocating adjuvant radiotherapy.


Forging is an industrial manufacturing method in which metal parts/components are shaped from feedstock (slugs) by applying compressive forces through various tools and dies. Where closed-die forging is the most common variant – see Figure 1 – this metalworking category also includes such processes as swaging and impact extrusion. Part shapes can be intricate, and as such it is a competitive process to casting. Forging may be done at room temperature (cold forging) or at elevated temperatures (warm/hot forging), each with its distinct assets and drawbacks. Although forging yields (near to) net-shape products, most forgings require some kind of finishing such as machining for reasons of accuracy and surface quality, heat treating to modify mechanical properties, and/or coating to enhance appearance or resistance to corrosion and wear.


The dynamic characteristics of new type hypocyclo idinternal combustion engine crankshaft was researched by using finite element and experimental modal analysis method.Built the 3D model of crankshaft by SolidWorks software,extracted the first 4 natural frequencies and mode shapes by the Block Lanczos method in ANSYS software,and also finished the crankshaft components experimental modal analysis through MISO hammer excitation method.The results show that the crankshaft's work frequency is far away from its natural frequency,avoid the resonance zone,verified the correctness of the finite element model,also provides a reference for the internal combustion engine crankshaft structure optimize.


Background:We previously reported (ACC03) preliminary findings of this study suggesting that high concentration of rapamycin blood level (>8ng/ml) is associated with a trend to low late loss and restenosis rate in patients(pts) undergoing coronary stent therapy. Methods:From December 2001 to February 2003, 76 pts with 103 arteries treated with stents were included in phase I (34 pts/49 arteries) and phase II (42 pts/54 arteries) of the ORAR study. A loading dosis of 6 mg of oral rapamycin was administered inmediately after stent deployment in all pts. In Phase I, 2 mg of oral rapamycin was given daily during 28 days. In Phase II 3 mg daily of rapamycin was given plus 160 mg of diltiazem during 28 days. Rapamycin blood levels were measured at third week in all pts.Cholesterol and triglycerides were evaluated before and after one month of treatment. Statins were given as well clopidogrel in all pts during six months. Angiographic binary restenosis, late loss, target lesion revascularization, treatment compliance,side effects and optimal concentration of the drug were analized. At the present time 6 month angiographic follow up data were available in 82.5% of the arteries. Results:Baseline clinical characteristics showed diabetes 25.2%, type B1, B2 and C lesions in 81%, reference vessel size <2.9 mm in 37% and with a lesion lenght of 11.1 + 0.8 mm. Minor side effects were present in 25% of the patients but only three discontinue the treatment (4%). Follow up quantitative angiographic data showed that pts having > 8 ng/ml compared with those having < 8 ng /ml had lower late loss ( 0.65 mm vs. 1.11 mm respectively p < 0.031), binary in stent restenosis (6.2% vs.23% respectively p < 0.039) and better MLD ( 2.16 mm vs.1.71 respectively p< 0.054) . Pearson test showed strong correlation between blood level of the drug and late loss ( r<0.001) Minor adverse side effects had a trend to increased with high blood concentration of the drug (p=0.083). Conclusions: Oral rapamycin after coronary stent deployment in those pts who reached high concentration of the drug are associated with low late loss, binary restenosis and better MLD in the follow up angiogram. A randomized drug / placebo study is ongoing (ORAR II).


Considerations are presented on the wall protection of inertial confinement fusion reactors by means of a falling cylindrical curtain of liquid metal that is intermittently contricted into a string...


In this paper, we presents real-time constraints we have to face while building a system to recognize activities of daily living in a smart home using Radio Frequency IDentification (RFID) tag. We also present how we addressed them.


In the last year, the Centers for Disease Control (CDC) published a loose-leaf manual, Guidelines for the Prevention and Control of Nosocomial Infections. One copy of the manual was sent to each hospital in the United States. Persons wanting additional copies were instructed to order them through the National Technical Information Service. In addition, the text of the manual was published in the March/April 1981, issue of INFECTION CONTROL. The manual contained the first of several guidelines that CDC is to publish for prevention of nosocomial infections. CDC is not presently prepared to distribute these guidelines to all U.S. hospitals, but expects to be able to do so within the next 12 months. A categorization scheme has been used to rank each of the recommendations in the guidelines. A full explanation of the scheme is in the manual and in the March/April 1981, issue of this journal.


Adriamycin, an anthracycline antibiotic is a powerful antineoplastic drug, but its therapeutic usefulness is limited by its cardiotoxicity. The present study investigated the effects of pretreatment with rosuvastatin and telmisartan alone or in combination against adriamycin induced cardiotoxicity in rats using biochemical approaches. The animals were divided into eight groups of 5 animals each. The first group received no drug(s) po but a single dose of distilled water (7.5 ml/kg, ip) at day eight, which serves as the control group. The second group received no drug(s) po but a single dose of adriamycin (15 mg/kg, ip) at day eight, and serves as adriamycin only received group. The third and sixth group received rosuvastatin (2 , 10) mg/kg/day respectively for nine days, and on day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. The fourth and seventh group received telmisartan (2 , 4) mg/kg/day respectively for nine days, and at day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. The fifth and eighth group received both drugs, where the fifth group Received both of rosuvastatin (2 mg/kg, po) and telmisartan (2 mg/kg, po), 1 hour apart, daily for nine days, and on day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. While the eighth group received both of rosuvastatin (10 mg/kg, po) and telmisartan (4 mg/kg, po), 1 hour apart, daily for nine days, and on day eight, one hour after drug administration, a single dose of adriamycin (15 mg/kg, ip) was given. At day ten of the study, blood samples were taken for biochemical analysis. Rats treated with adriamycin showed cardiotoxicity as evidenced by elevation of serum lactate dehydrogenase (LDH) activity, serum malondialdehyde (MDA) level, cardiac troponin (CTn-I) level and interluekine 17(IL-17) level. Pretreatment with rosuvastatin and telmisartan alone or in combination elicited a significant decrease in the activities of all markers measured in comparison with adriamycin treated group. These results suggest that both rosuvastatin and telmisartan treatment provides a significant protective effect against acuteadriamycin induced cardiotoxicity in rats.


Guo Moruo (1892-1978) played an important part in his country's political life.
Covered in honours in communist China, he wrote his self criticism just before
the Cultural Revolution. The late Michelle Loi, who had met him in 1971, devoted
this paper to his abundant and continuous work as an autobiographer. A writer of
first importance, the translater of Goethe's Faust, of Nietzsche's Zarathustra, a
poet, a novelist and a playwright, Guo Moruo wrote many autobiographical texts,
which Michelle Loi calls "autobiographical plays" though they were not meant for
the stage. The text covering his childhood years and his studies in Chengdu's high
school was translated into French under the title Autobiographie. Michelle Loi
emphasizes the part he played in the literary society named Chuangzao che
(Creation), which aimed at giving back their freedom to artists. She underlines
the distance between Guo Moruo and Luxun and, as concerns autobiography,
what distinguishes him from Guy Dafu, who also was a member of the Creation
group.


The importance of the mine selfignition and forecast for safe production in coal mines was described,and the shortcomings of the traditional predicting methods were discussed.The forecast model of the coal selfignition in mine concerned the time sequence was established based on the neural network.The model in the paper overcomed the shortages of the traditional forecast methods that had to determine the special function in advance,and increased the forecast veracity of the mine selfignition.


The life history characteristics of introduced Nile tilapia (Oreochromis niloticus L.) in Lake Victoria, including, sex ratio, fecundity, reproduction, weight-length relationship and body condition were studied and compared with those of other populations. Samples were collected by trawling and seining in the Kenyan sector of Lake Victoria between June 1998 and December 2000. Males predominated over females (sex ratio 1.42 : 1 : 00). O. niloticus spawned throughout the year but with a peak between December and June. Length at first maturity was (mean ± SD) 30.81 ± 0.09 for females and 34.5 ± 6 0.48 for males. There was little seasonal variation in relative condition, which ranged from 0.92 to 1.05 in males and 0.94 to 1.07 in females. Gonadosomatic index (GSI) was low during the postspawning period (July to October) and high during the protracted breeding period (December and June). Fecundity ranged from 905 to 7619 oocytes for fish of 28 to 51 cm total length (TL) respectively. The relationships between fecundity (F) and total length (L), weight (W) and ovary weight (OW) were: F ¼ 8.159L 1.53 , F ¼ 96.269W 0.4504 , F ¼ 1806 + 39.4OW. The slope b of the weight-length relationship was 3.08‐3.32 for males and 3.07‐3.22 for females. Growth was allometric in both cases and was significantly different from the expected value of 3. The life history strategy of O. niloticus is discussed in context of environmental changes occurring in the lake.


The clozapine levels in plasma were measured during the treatment of 18 male schizophrenic inpatients. A positive linear correlation was found between plasma clozapine levels and the doses given. However, the individual variation were so great that the relationship was not significant between the plasma levels and the clinical efficacy or the abnormal changes of EEG or ECG induced by the drug. Nevertheless, the measurement of plasma clozapine levels has potential significance for those with poor therapeutic effect and serious side effects to clozapine.


This paper deals with the suppression of mainlobe deceptive jammers in an orthogonal frequency division multiplexing-linear frequency modulation-multiple-input multiple-output (OFDM-LFM-MIMO) radar based on the blind source separation (BSS) algorithm. At the design stage, a colocated MIMO configuration is considered, where the LFM waveform is transmitted with a frequency increment across the antenna elements. After matched filtering in the receiver, the range-dependent degrees-of-freedom (DOFs) is obtained. Subsequently, the BSS algorithm based on joint matrix diagonalization operation is applied to separate the jammers and the true targets. Finally, the angles of true targets are estimated by utilizing the range-dependent compensation in the joint transmit-receive spatial frequency domain. Numerical simulations are provided to demonstrate the effectiveness of the proposed jammer suppression method.


It is argued that the way we teach, research and practise organizational psychology, and teach others to do so, is based on the erroneous assumption that we exist in non-unionised environments. The influence of union membership on behaviour in organizations is illustrated, the neglect of industrial relations by organizational psychologists documented, and the need for attitudinal, behavioural and ideological change by organizational psychologists is identified. During the 1950s, industrial/organizational (I/O) psychologists frequently researched industrial relations (IR) issues, such as simultaneous loyalty to company and union (e.g., Dean, 1954; Purcell, 1954). Thereafter, the 1950s were called the "golden decade" of psychological research into unions (Straus, 1977). Since then, the reciprocal relationship between I/O psychologists and unionists has been characterized at best by neglect, at worst by mutual mistrust, suspicion and ideological differences. Numerous reasons for this situation have been documented elsewhere (e.g. Huszczo, Wiggins & Currie, 1984), and include ideological and methodological differences between the study of I/O psychology and IR, and will not be repeated here. Rather, it will be argued that avoidance of studying the effects of unions as a central aspect of industrial relations psychology results in the construction and dissemination of a truncated body of knowledge regarding organizational psychology.