Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww.com/hemasphere/pages/default.aspx. Disclaimer: Articles published in the journal HemaSphere exclusively reflect the opinions of the authors. The authors are responsible for all content in their abstracts including accuracy of the facts, statements, citing resources, etc. 4065 is a steady increase in the prevalence of multiple myeloma from 61 to 170 patients, which is followed by a sharp decline in 2020 and 2021 to 151 patients. This calendar period coincides with the high prevalence of COVID-19 and increasing global mortality rates. These results are also consistent with the annual multiple myeloma mortality rates at our center, which remained low from 2012 to 2018 about 6-8%. However, there is a sharp increase in mortality from 2019 to 2021 to 18%, which is also linked to the COVID-19 pandemic. Beginning in 2022, the multiple myeloma mortality and prevalence rates began to return to pre-pandemic levels. Summary/Conclusion: Therefore, the data suggests that the COVID-19 pandemic between 2020 and 2021 may have led to an increase in mortality among MM patients and had a negative impact on their OS. Fig. 1. Overall survival of MM patients at different follow-up periods HemaSphere | 2023;7(S3) EHA2023 Hybrid Congress Copyright Information: (Online) ISSN: 2572-9241 © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. This is an open access Abstract Book distributed under the Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) which allows third parties to download the articles and share them with others as long as they credit the author and the Abstract Book, but they cannot change the content in any way or use them commercially. Abstract Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww.com/hemasphere/pages/default.aspx.Book Citations: Authors, Title, HemaSphere, 2023;7(S3):pages. The individual abstract DOIs can be found at https://journals.lww.com/hemasphere/pages/default.aspx. Disclaimer: Articles published in the journal HemaSphere exclusively reflect the opinions of the authors. The authors are responsible for all content in their abstracts including accuracy of the facts, statements, citing resources, etc. 4066


This paper presents an effective way to achieve a high level integration of signal and image processing methods in the general management of heart failure, by means of a clinical decision support system (CDSS). In particular, significant and suitably designed image and signal processing algorithms are introduced to objectively and reliably evaluate important features that can facilitate decisional problems in collaboration with the CDSS. Architectural details of the components of the CDSS needed for the seamless integration of image and signal analysis work-flows are finally discussed.


skrl is an open-source modular library for reinforcement learning written in Python and designed with a focus on readability, simplicity, and transparency of algorithm implementations. In addition to supporting environments that use the traditional interfaces from OpenAI Gym and DeepMind, it provides the facility to load, configure, and operate NVIDIA Isaac Gym and NVIDIA Omniverse Isaac Gym environments. Furthermore, it enables the simultaneous training of several agents with customizable scopes (subsets of environments among all available ones), which may or may not share resources, in the same run. The library's documentation can be found at https://skrl.readthedocs.io and its source code is available on GitHub at https://github.com/Toni-SM/skrl.


Genetics Terminology genetics – the study of heredity heredity – process by which genetic information is passed to next generation gamete a sex cell (sperm or egg) possessing half the full set of chromosomes. Is produced via meiosis. genotype genetic constitution of an individual using symbols such as BB, Bb, bb. phenotype the appearance of the individual with respect to a particular trait as produced by the genotype. dominant a form of a gene that suppresses expression of the other in the heterozygous condition. recessive a form of a gene that is hidden when occurring in heterozygous condition. Is expressed only when the determining gene is in the homozygous condition. homozygous having the identical two alleles (form of a gene) on homologous chromosomes. (BB or bb) heterozygous having different alleles on homologous chromosomes. (Bb) P1 parent generation F1 – first offspring generations (filial)


Automatic Term Recognition from technical texts has mainly two applications: on one side, assistance to lexicographers and documentalists; and on the other side, identification of key concepts for machine translation and information retrieval. Term recognition depends on the subject domain and the lexical patterns of a given language, in our case, Spanish. In this article, we present an evaluation of three different strategies for selecting candidates to term. In a second step, each LEA, XXXVII/2, 2015, págs. 173-197. 1 Trabajo financiado por el MICINN (TIN201


Information is the basis of policy-making, so how to guide companies to disclose inner- information fully and voluntarily is an urgent problem. On the basis of complete analysis in the dynamic system of companies' voluntary information disclosure, the essay points out some ways on how to improve companies' voluntary information disclosure.


Feature selection is the first and essential step for dimension reduction in many application areas, such as data mining and machine learning, due to its computational efficiency and interpretability of the results. This paper focuses on feature selection methods based on information theory. By studying and analyzing the ideas and drawbacks of existing feature selection methods, it finds that in the process of feature selection separately focuses on a candidate feature its individual relationship with the predicted class vector may lead to some problems. And we believe that when the candidate feature is combined with the selected features, its comprehensive discriminative ability should be taken as the evaluation index of the candidate feature. Therefore, we propose a novel feature selection method in this paper. In the proposed method, we introduced the equivalent partition concept and adopted the mutual information gain maximize (MIGM) criterion to evaluate the candidate feature. In order to estimate the performance of MIGM, we conducted experiments on ten benchmark datasets and two different classifiers, k-Nearest Neighbor (KNN) and Naïve-Bayes (NB). Extensive experimental results demonstrate that our method can identify an effective feature subset that leads to better classification results than other methods.


Repositories of digital educational resources have reached a significant level of development and diversification in the last decade to the point of becoming a component in higher education transformation. This paper presents a state-of-the-art review of the studies about the use and adoption of repositories of digital educational resources. Some quantitative approaches mainly collect metrics related to the publishing and reuse of educational resources. However, there is still insufficient empirical evidence to account for the types of adoption and use of educational repositories. There are few studies aimed at determining which are the dimensions of adoption of educational resources repositories by scholars, how the adoption of educational repositories overlaps in teaching practices, and which subjective, contextual, institutional, curricular, and instructional factors are involved in the different types of use.


MIXED LINEAGE ACUTE LEUKEMIA Mixed lineage acute leukemia (MPAL) is a rare subtype of acute leukemia defined on cytomorphological and particularly, on immunophenotypic grounds based on co-expression of markers of two distinct (e.g. myeloid and B-lymphoid) lineages in either one (biphenotypic MPAL) or ≥ two distinct blast cell populations (bi-lineal MPAL). Following previous reports of rare hybrid, biphenotypic, bilineal and ambiguous leukemias, MPAL was first recognized in the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues, as a unique poor-prognosis subtype of acute leukemia, in 2008 (1). In this classification, WHO further recognized the high biological heterogeneity of MPAL and subdivided it into three disease categories defined on genetic grounds. Since then, flow cytometry-based immunophenotypic criteria have been a cornerstone in the diagnosis of MPAL. In 2017 however, WHO diagnostic criteria for MPAL were revised, modified and to a certain extent simplified, while MPAL subclassification criteria remained unchanged (2). In the last decade, important contributions and (some) advances have been made in the field of MPAL and the understanding of this rare subtype of acute leukemia, which are scattered across a few hundred manuscripts in the literature including a few case reports and an editorial comment in Cytometry B (3–6). In this issue, Porwit and Bene (7), two authors who have most contributed to the definition of MPAL and the advancement of the knowledge about this unique subtype of acute leukemia (1,2,8,9), provide recommendations for correct immunophenotypic diagnosis of MPAL, together with a comprehensive overview of other investigations required for definitive diagnosis of MPAL. At the same time they offer the reader an up-to-date review of the most recent contributions in the field, particularly as regards the cytogenetic and molecular alterations described so far in MPAL, its great biological heterogeneity, and the potential role of early stem cell transplantation on improving outcome of MPAL patients (7). MULTIPLE MYELOMA Until the early 1990s flow cytometry was considered of limited value in multiple myeloma (MM). However, introduction of CD38 as a plasma cell (PC) gating marker (10), together with the development of multicolour flow cytometry demonstrated the great potential of flow-based immunophenotyping in distinguishing between normal and aberrant (clonal) PC, and further characterizing the latter cells (11–14). In recent years, immunophenotypic monitoring of minimal residual disease (MRD) after therapy using high-sensitive flow cytometry (15,16) has become recognized as one of the most powerful parameters to evaluate response to therapy in bone marrow, and to predict patient outcome (17,18). As a consequence, flow-MRD has become part of the treatment-decision making process in many recent clinical trials (19). Here, Rossi et al. (20) used an in-house developed six-color flow cytometry assay to compare response to therapy in patients undergoing single vs double transplant. Their results show the potential benefit of a double transplant based on its association with better clearance of myeloma cells in bone marrow. In order to be able to translate these results into routine practice at distinct laboratories, standardization is mandatory (19). This is clearly highlighted in this issue in the work presented by Scott et al. (21), who report on the high sensitivity and good linearity observed in an International Inter-Laboratory Study based on dilutional series of MM samples.


Many historical studies on heritage emphasize the legal dimension, in large part because the history of cultural heritage is deeply rooted in the law – and, inevitably, therefore, closely interlinked with the history of the State. Cultural heritage maintains a very complex relationship with the law on the one hand, and with the State on the other hand, a relationship that cannot be reduced to the mere instrumentalisation of cultural heritage by State, by means of the law. This article examines the central role played by the law in the heritage debate from two different perspectives. First, from an extra-legal perspective, this article investigates the role played by the law in the construction of heritage. Secondly, from an internal perspective, it looks at how heritage has been defined and mobilised by the French legal system. Does the heritage law simply express the State's power deployed in favour of the preservation of heritage? Or does it reveal the conviction, more or less clearly expressed, that heritage is a shared and collective resource?


HE DISCUSSION OF HENRY V CAME EARLY IN THE SPRING semester of 1989, and the chief executive officer of one of Mississippi's largest corporations held the floor. "Henry demonstrated his power early," he argued, "by executing the conspirators against his life. After that, he followed through by killing his prisoners. These were executive decisions that he made because he had to. No one else could. Then, when he could have simply married Catherine as her conqueror, instead he wooed her, persuaded her to love him and thus consolidated his empire." The political consultant interjected, "But the wooing of Catherine is more like the executing of the prisoners than you admit. Both acts show Henry's ruthless pursuit of power. Catherine is imprisoned too-no less than the French he killed. Her tortured attempts to speak what has become the language of power must be a kind of death for a proud princess of France." When the banker and the physician entered the discussion, it was to correct Shakespeare's medieval history. If Shakespeare could not get his facts straight, they argued, then we had better do some research to gain a more accurate view of the world he is dramatizing. But the attorney had the last word on that Thursday morning. "In my office," he said, "I tend to make and enforce policy from the top, so that the junior partners know what course we'll be taking. But seeing Henry wander through the camps on the night before the battle, and hearing him make his St. Crispian's Day speech, I'm beginning to wonder what it takes to lead by consensus. How could I do that? What would I accomplish?"


Presentations were made on current situation and achievement of forestry extension from mechanism,system and effect in Hangzhou,Zhejiang province.Facing challenges of mechanism,input,techniques,relationship between production and research,extention methods,manpowers,etc.,countermeasures were offered.


This paper presents a novel ocean vector wind (OVW) retrieval algorithm that uses the Precipitation Radar (PR) and the TRMM Microwave Imager (TMI) on board of the Tropical Rainfall Measuring Mission (TRMM) satellite. In this paper, the modified 2nd Stokes parameter (weighted difference of V & H-pol Tb's) is used to cancel the atmosphere, which enhances the Wind Direction (WD) signal. Therefore, by combining linearly polarized Tb measurements with the anisotropic backscatter signature of the Ku-band scatterometer, it is possible to retrieve both the corresponding Wind Speed (WS) and WD of the ocean surface wind. Examples of retrieved ocean winds are compared with collocated GDAS wind vectors.


Product properties for innovative materials, e.g. dual phase steels, require precise control of production processes. Difficulties in optimization of process parameters correspond with large number of control variables, which should be considered in the technology design. Sensitivity analysis allows evaluating the importance of all process inputs on the final properties of material. Information on the most important inputs is crucial for further design of the process. Application of sensitivity analysis requires detailed knowledge of the process phenomena as well as the definition of the mathematical model of the thermomechanical process. Furthermore, some sensitivity analysis algorithms are of the high computational cost. Presented work concerns possibility of the application of data exploration approach in evaluation of the importance of process inputs as the alternative for sensitivity analysis. Use of data mining algorithms eliminates necessity of mathematical model development, it also does not require any apriori knowledge about the process. Authors presents the comparison of sensitivity analysis and data exploration approach in evaluating relationships between inputs and outputs of the hot rolling for dual phase steel strips. The presented approach and the perspectives of the practical application could lead to significant decrease of time necessary for the computations of process design. The theoretical considerations are supplemented with the results of both types of analysis.


A method is disclosed for straightening a stack (P) of sheet material that has been deformed after conveyance on a roller conveyor (4), the rollers of which are mounted around parallel axes of rotation (5) extending transverse to the direction of conveyance of the stack (P), consists of putting the stack (P) in engagement with a stop surface (32) and driving the axes (5) of the rollers on which the stack (P) rests in a movement of translation in the direction of conveyance of the stack (P), allowing the rollers to rotate freely around their respective axes of rotation (5).


Oxidative stress is a central feature of diabetes and plays a causal role in the pathogenesis of diabetic complications. The nuclear factor-like 2 (Nrf2) transcription factor mediates the induction of antioxidant and cytoprotective genes and is a major regulator of the endogenous antioxidant and detoxification systems. Multiple aspects of the Nrf2 signaling pathway are aberrant in diabetes and simultaneously targeting the dysregulated aspects of the Nrf2 signaling pathway ought to be considered.


The lateral load distribution pattern reflects the distribution of lateral inertial forces applied to the structure caused by the earthquake. Inertial forces caused by earthquakes w ith time changes and dynamic characteristics of the building are subject to change. But in the non-linear static analysis in or der to avoid the complexity of this method, forces during analysis are considered constant. Hence analysis and design codes suggest d ifferent lateral load patterns to minimize the impa ct of this unrealistic simplicity. Pushover analysis is of non-linear stat ic analysis methods that can be used to obtain stru ctural capacity curve. Effective factors in determining the capacity curve of the structure is the lateral load distribution. This paper examines the triangular lateral load pattern in structures with convergent bracing previously placed under linear s t tic analysis and a threedimensional frame structure as an example was analy zed in the SAP2000 software. Therefore pushover ana lysis was performed on the several frames with convergent crossover bra ces (with 3,5,7,10,15 number of floors) and extra s ength values, ductility and behavior factor is obtained and he results are compared with a nonlinear time history dynamic anal ysis. Also effect of the parameters affecting the rate of behavior such as, Ir nian and American sections of beams and columns, double stud sections, will be examined for braces.


This report describes revisions to the UTCS-1 Traffic Simulation Program to reduce computing (CPU) time, reduce data transfer (I/O) operations, and to reduce storage requirements. The work effort included: 1. Refine the existing code; 2. Incorporate the capability for a variable simulation time-step; 3. Abridge the existing fuel consumption and vehicle emission rate tables; 4. Pack the above tables to conserve storage; 5. Revise two major routines and develop a new car-following model. The estimated result is to reduce CPU time by at least 30 percent, reduce I/O operations by at least 90 percent and reduce required storage by approximately 10 percent. This volume is the fourth in a series of five. The others are: Vol. 1 80/086 Executive Summary; Vol. 2 80/087 Design of the TRAF Operating System (TOS); Vol. 4 80/088 Revisions to the UTCS-1 Traffic Simulation Model to Enhance Operational Efficiency; Vol. 5 80/089 TRAF Operating System Program Documentation. (FHWA)


HighlightsAERMOD and SCIPUFF were employed to back-calculate farm-level PM10 emission rates based on inverse modeling.Both AERMOD and SCIPUFF did not capture the diurnal and seasonal variations of farm-level PM10 emission rates.AERMOD modeling results were affected by wind speed, with higher wind speed leading to higher emission rates.Higher numbers of receptors and PM10 measurements with greater time resolution may be recommended in the future.Abstract. Air pollutant emissions from animal feeding operations (AFOs) have become a serious concern for public health and ambient air quality. Particulate matter with aerodynamic equivalent diameter less than or equal to 10 µm (PM10) is one of the major air pollutants emitted from AFOs. To assess the impacts of PM10 emissions from AFOs, knowledge about farm-level PM10 emission rates is needed but is challenging to obtain through field measurements. The inverse dispersion modeling approach provides an alternative way to estimate farm-level PM10 emission rates. In this study, two dispersion models, AERMOD and SCIPUFF, were employed to back-calculate farm-level PM10 emission rates based on hourly PM10 concentration measurements at four downwind locations in the vicinity of a commercial egg production farm in the southeast U.S. Onsite meteorological data were simultaneously recorded using a 10 m weather tower to facilitate the dispersion modeling. The modeling results were compared with PM10 emission measurements from two layer houses on the farm. Single-area source, double-area source, and double-volume source were used in AERMOD, while only single-point source was used in SCIPUFF. The inverse modeling results indicated that both SCIPUFF and AERMOD did not capture the diurnal and seasonal variations of the farm-level PM10 emission rates. In addition, the AERMOD modeling results were affected by wind speed, and higher emission rates may be predicted at higher wind speeds. The single-point source for SCIPUFF, the plume rise simplification for AERMOD, and insufficient concentration measurement resolution in response to temporal changes in wind direction may have added uncertainties to the modeling results. The results of this study suggest that more receptors covering more representative downwind locations should be considered in future modeling for farm-level emissions assessment. Moreover, ambient data collection with greater time resolution (e.g., less than one hour) is recommended to capture diurnal and seasonal patterns more rigorously. Only in this way can researchers achieve a better understanding of the effectiveness of inverse dispersion modeling for estimation of pollutant emission rates. Keywords: AERMOD, Animal feeding operations, Egg production, Farm-level emission rate, Inverse dispersion modeling, PM10, SCIPUFF.


Objective To establish an orthotopic lung transplantation model in the rat, and to evaluate the effects of CZ 1 solution for pulmonary preservation.Methods A total of 18 rats were randomly divided into 3 groups with 5 rats in each group: control group (flushed with equilibrium liquid and transplanted immediately), CZ 1 group (flushed and cold preserved with CZ 1 solution within 8h, then transplanted), and Euro Collins(E C) group (flushed and cold preserved with E C solution, then transplanted). The studied parameters included the ischemia time, PaO 2, PaCO 2, ratio of wet weight to dry weight and the pathological changes of lung grafts. Results For ischemia time, no significant difference between CZ 1 group and E C group was found. For PaO 2, there was a significant difference between control group and CZ 1 group, also between CZ 1 group and E C group. For PaCO 2, there was no significant difference between control group and CZ 1 group, but a significant difference between CZ 1 group and E C group. The ratio of wet weight to dry weight in the control group was apparently higher than in CZ 1 group and E C group, but in E C group it was apparently higher than in CZ 1 group after pure cold preserved. After transplantation and reperfusion, the ratio of wet weight/dry weight in CZ 1 group and E C group was apparently higher than in control group, but in E C group it was higher than in CZ 1 group. The pathological lesions in CZ 1 group was milder than in E C group.Conclusion CZ 1 solution was more effective than E C solution during the 8 h lung preservation.


Study involved 60 patients from age of 29 to 79 years with diagnosis of lumbar dorsopathy complaining severe pain in back and lower extremities. Control group included 21 healthy individuals of similar age and gender. Psychological status was investigated with Standardized Multifactorial method of Studying Personality (SMSP) short version of MMPI questionnaire. Chronic back pain in the patient with dorsopathy is formed on the background of premorbid neurotic personality and thus should be considered while choosing preventive and curative measures.


The annual Economic Outlook for Southeast Asia, China and India examines Asia's regional economic growth, development and regional integration process. It focuses on the economic conditions of Association of Southeast Asian Nations (ASEAN) member countries: Brunei Darussalam, Cambodia, Indonesia, Lao PDR, Malaysia, Myanmar, the Philippines, Singapore, Thailand and Viet Nam. It also addresses relevant economic issues in the People's Republic of China and India to fully reflect economic developments in the region.


The optimal feature subset selection over very high dimensional data is a vital issue. Even though the optimal features are selected, the classification of those selected features becomes a key complicated task. In order to handle these problems, a novel, Accelerated Simulated Annealing and Mutation Operator (ASAMO) feature selection algorithm is suggested in this work. For solving the classification problem, the Fuzzy Minimal Consistent Class Subset Coverage (FMCCSC) problem is introduced. In FMCCSC, consistent subset is combined with the K-Nearest Neighbour (KNN) classifier known as FMCCSC-KNN classifier. The two data sets Dorothea and Madelon from UCI machine repository are experimented for optimal feature selection and classification. The experimental results substantiate the efficiency of proposed ASAMO with FMCCSC-KNN classifier compared to Particle Swarm Optimization (PSO) and Accelerated PSO feature selection algorithms.


An experimental study of the ratio of intensities of the central line, in the molecular scattering of light, to the Brillouin components has been made in molten NaNO3 over a temperature range from 310° to 450°C. The measurements were performed at frequencies just below any relaxation frequency. The relative intensities of the fine structure components are compared to the Landau–Placzek ratio and also to the generalized Landau–Placzek ratio, applicable to relaxing liquids.


As stated in the United Nations' Sustainable Development Goals, poor mental well-being is one of the biggest problems we are facing worldwide. One possible way of addressing it is through interventions delivered via digital devices since they are scalable, ubiquitous and inexpensive. This is also confirmed by the ever-growing plethora of e-health mobile apps being developed. Although these apps rely to some extent on scientific bases, there is still much work to do to understand the effect of specific digital interventions on app users. To shed light on these effects, we ask what types of interventions within the app have the most significant impact on well-being, and to what extent longer engagement leads to improved outcomes. These questions could be answered with dedicated Randomized Controlled Trials (RCTs), which are generally expensive, time-consuming, and single-purposed. To overcome these difficulties, we adopt instrumental variables on a combination of data collected in an RCT, behavioural data from the app, and a randomized recommender system, to evaluate intervention and app dose-response effects on users' self-reported well-being. Thus, we present a general causal inference approach for extending results from collected data in RCTs applied in the context of digital health intervention. Following this approach, we show how to measure the impact of different types of activities on the users' well-being. This allows us to identify the most impactful activities in the app (namely, sleep and relaxation activities), which have direct implications for the app design. On the other hand, we prove the positive effect of longer app usage.


Within the limitations of restricted choice of nematicides, research attempts shall be directed to developing alternative nematode control strategies. A correlative study was conducted to compare the effect of snow manipulations over the soil temperature with the laboratory results of potato rot nematode (Ditylenchus destructor Thorne) survival. Soil temperature was measured by data loggers buried in 5 cm soil under thick snowpack, densified snow base and under the bare ground from where the snow was removed. The results confirm the suggestion that the natural snow cover isolates the ground surface from the negative temperature extremes, and the consequent survival of potato rot nematodes is not likely to be reduced. on the other hand, snow densification prior to the arrival of a cold front resulted in a significant temperature drop down to −2oC, which may cause more than 50% mortality of the most temperature sensitive age group, i.e. younger larvae. The most efficient soil temperature manipulation was snow removal, which may result in 90% mortality of adults and fourth-stage juveniles in exposed soil strata. None of the tested treatments were able to guarantee 100% mortality of any of the life stages involved in the comparison. We suppose the methods are appropriate for further efficiency testing in heavily infested fields, especially in small scale and ecologically sustainable agriculture.


Abstract G. A. Cohen's critique of the Rawlsian difference principle points out an inconsistency in its presentation. The initial equality decided by the participants in the original position under the veil of ignorance is not preserved by the inequality sanctioned by the difference principle. Cohen shows how the breakdown of the initial equality prevents the desired results of the Rawlsian system from being realized. He argues that an egalitarian ethos is required within a society for equality-preserving economic distributions and Pareto-superior outcomes to occur. Nonetheless, Cohen's analysis of Rawls misses the ultimate cause of inequality, which is the dynamics of capital accumulation. An egalitarian ethos is only possible if there is a socialist mode of production to facilitate its development. Additionally, Cohen's critique of Rawlsian constructivism through an argument for intuitionism does not address the natural-material existence of human beings. This existence must be considered for any theory...


Abstract Deep-level transient spectroscopy (DLTS) has been used to characterize bulk defect states in single-crystal boules of CdS grown from the vapour phase. Two centres are present in as-grown material with activation energies of 0˙29 eV and 0˙44 eV. However, annealing the crystals in either Cd or S appears to introduce two additional levels with activation energies of 0˙61 eV and 0˙74 eV. The 0˙61 eV centre exhibits unusual behaviour in that the associated DLTS peak is observed in the spectrum only after the sample has been illuminated with light of energy greater than about 1˙1 eV. If the sample is maintained in the dark for some time, the DLTS peak disappears but can be recovered again by exposure to light. Apparently this cycle can be repeated indefinitely. Parallel observations in the scanning electron microscope have shown that the annealing process also produces a network of extended defects and subgrain boundaries. Some of these have been found to be electrically active using the electron-beam-...


Abstract A case study of a convectively coupled Kelvin wave in the eastern Pacific intertropical convergence zone (ITCZ) is presented, as observed during the 1997 Pan American Climate Studies (PACS) Tropical Eastern Pacific Process Study (TEPPS). The large-scale convective envelope associated with this disturbance, with a zonal scale of approximately 1000–2000 km, propagates eastward at 15 m s−1 along the mean convective axis of the ITCZ. This envelope consists of many smaller-scale, westward-moving convective elements, with zonal scales on the order of 100–500 km. As the convectively coupled Kelvin wave disturbance propagates eastward, it exerts a strong control on local convection. Radar and vertical profiler data collected aboard the NOAA R/V Ronald H. Brown during the wave passage show that convection deepens rapidly as the Kelvin wave approaches from the west, progressing from isolated, shallow cumuli to organized deep convective features within just 12 h. Initially, rainfall in the vicinity of the s...


The boundedness on Hardy spaces are established for the parametrized area integral μρΩ,S and the Littlewood-Paley g*λ function μ*,ρΩ,λ with variable kernels.


The enactment of the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) in 1980 gave the Federal government, for the first time, the authority to take direct action or force the responsible party to respond to emergencies involving uncontrolled release of hazardous substances. The Act set up a five year program and established a trust fund -- ``the Superfund`` -- of $1.6 billion. The primary authorities contained in CERCLA enabled the Federal government to perform cleanups at sites where there were no responsible parties and to respond to emergency situations involving hazardous materials. Since the last reauthorization of Superfund, specific areas of concern, including program administration, have come to light. All parties agree that legislative changes are needed to reform the current program. As it stands now, cleanup levels are inconsistent, cleanup costs are excessive, and State and local governments have little say in the decision making process that affects their economic and social well being. Reforming Superfund will potentially make the program more equitable, effective, and efficient. This paper will focus on four of the major components of the Superfund program: (1) community involvement, (2) State involvement, (3) liability of responsible parties, and (4) remedy selection. In addition tomore » highlighting current provisions of the law, potential reforms introduced in both the 103rd and 104th Congresses relating to each of the four areas will also be discussed.« less


BACKGROUND: The morbidity of breast cancer has continuously achieved a global topicality. In particular, during the last decade several ten thousand female adults in Taiwan have been confirmed as breast cancer patients. OBJECTIVE: To predict the survival rate of breast cancer patients at various (0-IV) stages and provide efficient assessment of proposed radiotherapy for patients. METHODS: The prediction algorithm proposed is based on the revised hit and target model and implies the application of Taylor series expansion to the population-based survey dataset. The proposed algorithm features a specific function comprising a single simple exponential term exp(-αt) to imply the fundamental degradation of patient's health multiplied by an additional term P(αt), which specifies the recovery effect of a particular therapy. RESULTS: Its calculated values for breast cancer patients who undergone radiotherapy at different stages 0-IV were {0.0029, 0.0066, 0.0178, 0.0475, 0.1785} yr-1, respectively, while those for corresponding groups of patients with no radiotherapy were assessed as {0.0072, 0.0137, 0.0264, 0.0913, 0.2425} yr-1. CONCLUSIONS: The revised algorithm successfully interpreted the breast cancer patients' survival rate at stages 0-IV and evaluated the necessity of radiotherapy for patients at various stages as well.


The invention discloses a method for eliminating carbon defects of lost foam casting products, which includes manufacturing of foam models, brushing of coating, drying, modeling in a casting box, vacuum pumping and casting under negative pressure in the process of casting by adopting vacuum lost foam. Burning foam models are added in the process of vacuum pumping before the procedure of casting under negative pressure so that casting cavities are formed in the previous space of foam models after the foam models are burned up, and then casting is carried out under vacuum conditions; burning ports of burning models and slag bags of burning residues are remained on the foam models, and the thickness of the coatings on the models is more than 2 mm. The invention can eliminate carbon defects of casting pieces, such as carbonization or carbon distribution, and the like caused by lost foam gasification in the process of lost foam casting thoroughly.


Summary:  Purpose: The purpose of this study was to investigate preschool teachers' perceptions to children with epilepsy and asthma in middle areas of Taiwan.


Foreword (Andreas Rett) Introduction: Background Aim Sample Methods Development and Progress in Rett Syndrome The Individuals in the Study Typical Symptoms and Behaviors: Deficiencies in Perception and Sensory Integration Stereotypical Behaviors Dyspraxia - "Want of Success" Severe Motor Disabilities Difficulties in Coordination Mental Retardation Communication Disorders Emotional Channels Large Fluctuations in Behavior Emotional Reactions Insecure Identity Guidelines for Treatment and Teaching: Two Principal Teaching Groups Multi-handicap Understanding the Environment Using the Body Interacting and Communicating with the Environment Being Active Expanding One's World Appendices: Questions Forming a Basis for Interviews with Parents Questions Forming a Basis for Interviews with Parents/Care Givers Questions Forming a Basis for Interviews with School Staff References.


An appreciation of distance is important in all studies of travel behavior. However, the impressions of distance that travelers hold in their minds are often very different from real distance. Such "cognitive distance" tends to be overlooked in travel research. A study of tourist impressions of distance on the east coast of Australia shows that such distance is overestimated relative to reality. It also suggests that the distance cognition of tourists differs from that of permanent residents and that the process of distance cognition is influenced by a range of factors.


In this paper, we establish a dynamic model of the hyper-chaotic finance system which is composed of four sub-blocks: production, money, stock and labor force. We use four first-order differential equations to describe the time variations of four state variables which are the interest rate, the investment demand, the price exponent and the average profit margin. The hyper-chaotic finance system has simplified the system of four dimensional autonomous differential equations. According to four dimensional differential equations, numerical simulations are carried out to find the nonlinear dynamics characteristic of the system. From numerical simulation, we obtain the three dimensional phase portraits that show the nonlinear response of the hyper-chaotic finance system. From the results of numerical simulation, it is found that there exist periodic motions and chaotic motions under specific conditions. In addition, it is observed that the parameter of the saving has significant influence on the nonlinear dynamical behavior of the four dimensional autonomous hyper-chaotic system.Copyright © 2014 by ASME


The natural characteristics affecting the amount of solid waste in the study area were studied through repeated field visits to the area and observation of solid waste on the soil in the hot and cold seasons. Data related to this study, including climatic data, were collected by government departments in the center of Nasiriyah district. In this research, we included the study of the natural characteristics and their contribution to increasing the amount of solid waste and its impact on the soil, including: the surface of the Nasiriyah district center and the climate and the study of its elements represented by solar radiation, temperature, moisture, evaporation, wind, dust phenomena and rain fall, as well as the study of each of the soils  in the study area and an indication of its types and water resources.


...............................................................................................................................2 Dedication ............................................................................................................................5 Acknowledgements ..............................................................................................................6 CHAPTER 1: INTRODUCTION ......................................................................................14 Preface................................................................................................................................14 Context and Background....................................................................................................17 Statement of the Problem ...................................................................................................23 Statement of Purpose and Research Questions ..................................................................23 Research Approach ............................................................................................................24 Researcher's Assumptions .................................................................................................25 Rationale and Significance of the Study ............................................................................26 Dissertation Overview .......................................................................................................27 Glossary of Key Terminology ...........................................................................................28 CHAPTER 2: REVIEW OF LITERATURE .....................................................................31 Identifying the Literature ...................................................................................................31 Literature on Emerging Adulthood ....................................................................................32 Cognition in Emerging Adulthood.........................................................................34 Mental Health Issues in Emerging Adulthood .......................................................35 Literature on Adult Development ......................................................................................37 Stages of the Life Course .......................................................................................38 Literature on the Life Course .................................................................................43 Literature on Women's Development ................................................................................45 UNDERSTANDING WOMEN ENTERING THE WORKFORCE 10 Issues in Women's Development...........................................................................45 Relational-Cultural Theory ................................................................................................46 Identity in Women's Development ........................................................................50 Achievement in Women's Development ...............................................................52 Literature on Career Development .....................................................................................53 Career Development Theories ...............................................................................53 Research on Women's Career Development .........................................................56 Transitioning into the Workforce...........................................................................57 Summary ............................................................................................................................59 CHAPTER 3: METHODOLOGY .....................................................................................61 Pilot Study ..........................................................................................................................61 Sampling Methods .............................................................................................................63 Defining the Target Group .....................................................................................63 Selecting the Research Participants .......................................................................64 The Research Participants ......................................................................................66 Data Collection and Analysis Procedures ..........................................................................67 Data Collection ......................................................................................................70 Data Analysis .........................................................................................................73 Stage 1: Immersion ....................................................................................75 Stage 2: Understanding ..............................................................................78 Stage 3: Abstraction ...................................................................................79 Stage 4: Synthesis and Theme Development .............................................80 Stage 5: Integration and Critique ...............................................................80 UNDERSTANDING WOMEN ENTERING THE WORKFORCE 11 Ethical Considerations .......................................................................................................81 Researcher's Ethical Standards ..............................................................................81 Institutional Review Board and Informed Consent ...............................................82 Trustworthiness ......................................................................................................83 Limitations .........................................................................................................................85 Summary ............................................................................................................................87 CHAPTER 4: RESEARCH PARTICIPANT SUMMARIES OF EXPERIENCE ............88 Research Participant Summaries of Experience ................................................................88 Meghan ..................................................................................................................89 Stephanie ................................................................................................................92 Ashley ....................................................................................................................94 Jennifer ...................................................................................................................97 Samantha ..............................................................................................................101 Lauren ..................................................................................................................103 Elizabeth ..............................................................................................................105 Brittany ................................................................................................................107 Jessica ..................................................................................................................110 Amber ..................................................................................................................113 Summary ..........................................................................................................................115 CHAPTER 5: FINDINGS AND ANALYSIS .................................................................116 Major Findings .................................................................................................................116 Experiencing a Shift in Self-Perception in the Context of Choice ......................117 Experiencing a Shift in Self-Perception in the Context of Achievement... .........119 UNDERSTANDING WOMEN ENTERING THE WORKFORCE 12 Experiencing Emotional Conflict and Coping Strategies Employed ...................120 Experiencing Health and Well-Being in the Context of Support Systems ..........123 Analysis and Interpretation of Findings ...........................................................................124 Choice and Emotions ...........................................................................................126 Achievement, Emotions, and Self-Perception .....................................................132 Emotional Conflict and Coping ...........................................................................137 Support Systems and Connection ........................................................................142 Revisiting Assumptions from Chapter 1 ..........................................................................146 Summary ..........................................................................................................................147 CHAPTER 6: CONCLUSIONS AND RECOMMENDATIONS ...................................149 Significance of the Study .................................................................................................150 Conclusions and Recommendations ................................................................................150 Strengths and Limitations ................................................................................................160 Strengths ..............................................................................................................160 Limitations ...........................................................................................................161 Future Research ...............................................................................................................163 Researcher Reflection .........................................................................


Automatic Image Annotation (AIA) tries to minimize the manual effort for image annotation. However, the performance of the AIA approaches is not satisfactory. The interaction of user is needed to solve this problem. The annotation is refined during the interaction by using semantic-based relevance feedback. This approach has a limit as only the annotations of found images during the interaction are updated. In this paper we introduce a novel method of semi-automatic annotation. The method is using visual feature representations of keywords which are improved during the region-based relevance feedback. The experiments show that this method gives good results and can be used to update the annotations for all images.


POLISH INDUSTRIAL LAW 1927-1939 Summary Mutual relations between the state and industry have changed substantially in the early twentieth century. Formed the major national ompanies which have obtained legal protection acquired economic position. A manifestation of protective measures was the introduction of the concession to operate certain industrial activities. Duty concession staggered principle of freedom of industry and introduced the principle of regulation (licensing). For the period above accounted for the first codification of Polish coherent industrial such as regulation of the Polish President on 7 June 1927, industrial law, with effect from 16 December 1927, modeled primarily on the Austrian and German law on industrial property. The Act contains no provisions industry standard for the period of capitalism the first quarter of the twentieth century, and is due to the contemporary system of economic relations, which gave her more than once on the archaic nature of some regulation. In addition to the undoubted success of the enactment of uniform laws for the whole country was to move the industry with its provisions explicitly the principle of art. March 101 of the Constitution places the freedom to choose classes and earn money. A reflection of this was the provision of Article. 3 industrial law, under which the industry was to conduct free and allowed anyone, unless the provisions of industrial law did not provide that the exception or limitation. Statutory definition of industry modeled on the achievements of the jurisprudence of the German industrial law, defined it as any employment or business carried out by itself, a commercial and professional use, no matter whether it was the activities of producing, processing, trade, or services. The Act divided the industry into two basic categories: a permanent base– industry-free, fully licensed and crafts as well as no permanent residence (circular). Sometimes a third category of industries considered to run theindustry at the fair. Launch of free industry, with permanent residence, which was not subject to duty concession notice required an industrial power of the first instance. Industrial authority without undue delay seemed receipts stating the order number, under which he was entered in the register of industrial powers. The registration obligation imposed on both individuals and legal persons. Licensed industry was industry, with permanent residence, whose launch was dependent on receipt of the concession. Industrial Law provided a long list of licensed industries, while accepting the principle that only those types of industry should be forced to obtain licenses, that are thus due to the important public interest and national security had to be made subject to strict conditions. Craft was the peculiar kind of industry, with permanent residence, which could be performed only way to craft. Industry without a permanent seat was called industry is defined as a circular gainful employment, self-made, professionally and personally without a permanent seat in the industrial field, for example, selling goods in other places other than goods intended for sale. The person who wanted to lead the industry circular was required to obtain a license, which has provided industrial power of the first instance in the form of an administrative decision. It was not possible to start and perform circular industry before obtaining a license. One of the major forms of trade in the interwar period was the sale takes place at the fair. The activities fair was regulated in the law industry as a special type of industry and subject to strict legal restrictions. The basic condition of business was to obtain a fair municipality's powers to conduct fair markets (the property or place) and keeping it in the days and hours established in the regulations. In terms of industrial law in the new political and economic conditions have occurred in Poland after 1944. It is very interesting that its provisions were not considered to be contrary to the principles of contemporary legal and political system, becoming the instrument of delivery volume of private economic activity for the so-called national economy. Therefore, the provisions of the Regulation in force until 1972.


A method for the determination of transmission characteristics of a transmission network in which a digital test signal is converted is transmitted to an analog signal, through the network under control of a burst signal, and is detected on the receiver side. Transmission characteristics are calculated on the basis of the ratio of the received and the transmitted digital signal.


Abstract Virtual Australia is not a well-defined or agreed concept. This discussion paper conceptualises Virtual Australia as a 'virtual [digital] model containing and representing all non-trivial objects and their contextual environment – from blue sky to bedrock – in real world Australia'. It describes a scenario for Virtual Australia, one or two decades from now, in which the locations and conditions of non-trivial objects and their environment are updated automatically through a combination of remote sensing and wireless communication technologies in support of a 'Supranet'. It then examines the concept of the 'Supranet' – a pervasive information network based largely on wireless technology linking the physical world to a virtual model in real time – and develops and discusses three principal characteristics of the Supranet: the ability to have or collect specific information (know); the ability to process information (think); and the ability to communicate that information. If, in the near future, any or all non-trivial devices are to some extent able to know, think and communicate, the potential for object autonomy will be realised.


metaphysician. It shows that metaphysics is a difficult discipline, even an obscure one, yet none the less inevitable. (One may of course dig one's head into the sand with the positivist if one so chooses, but that is surely a very foolish attitude to adopt.) It also shows how important in the metaphysical realm is the analogical method and how important it is that we should try to understand this method. But my doubts are about the book's denial of knowledge of being other than analogical knowledge. When I use a symbol must I not have some knowledge of that which is symbolized ? And when I use analogies must I not also know sufficient about that which is being depicted by means of the analogy to recognise it ? Can I have an analogy of the completely unknown? Miss Emmet, of course, would admit that I cannot. But she has so little to say about this non-analogical knowledge. The only relief from subjectivism provided us is found in obscure relationships, such as, for instance, "a sense of impingement" or finding oneself in "a situation of relatedness." Surely, our knowledge of being is not so slight and so vague as Miss Emmet's theory implies. I have criticized a great deal, but my final word must be one of thanks for a splendid piece of philosophical writing, which perhaps if I had studied more I should have understood better and criticized less. I have heard that Miss Emmet wrote most of this book whilst fire-watching. Never were those dreary hours put to better use! R. I. AARON.


AI-based recommender systems have been successfully applied in many domains (e.g., e-commerce, feeds ranking). Medical experts believe that incorporating such methods into a clinical decision support system may help reduce medical team errors and improve patient outcomes during treatment processes (e.g., trauma resuscitation, surgical processes). Limited research, however, has been done to develop automatic data-driven treatment decision support. We explored the feasibility of building a treatment recommender system to provide runtime next-minute activity predictions. Th e system uses patient context (e.g., demographics and vital signs) and process context (e.g., activities) to continuously predict activities that will be performed in the next minute. We evaluated our system on a prerecorded dataset of trauma resuscitation and conducted an abla-tion study on di ff erent model variants. Th e best model achieved an average F1-score of 0.67 for 61 activity types. We include medical team feedback and discuss the future work.


Minorities' journalism is an important component of journalism inChina.Facing the new situation of building a harmonious society,minorities' journalism should sum up experiences,play a more important role in pushing economical construction forward,propagandizing the policies for minorities and promoting the advanced culture.


Tapinarof is a novel topical formulation approved recently, in May 2022, by the United States Food and Drug Administration to treat plaque psoriasis. Existing topical therapies for psoriasis are limited by systemic and local adverse effects, medication cost and repeated administration, thus significantly hampering the compliance of patients to therapy. These limitations can be resolved by tapinarof owing to its better efficacy and favourable safety profile in psoriasis management. Tapinarof was developed with a unique mechanism targeting the aryl hydrocarbon receptor (AhR) involved in inflammation and modulation of skin barrier integrity in inflammatory dermatological disorders such as psoriasis and atopic dermatitis. The efficacy and safety outcomes of tapinarof in psoriasis were justified through the two pivotal clinical trials, namely, PSOARING 1 and PSOARING 2. The common adverse effects observed with tapinarof are folliculitis, contact dermatitis and headache. The literature search was conducted for efficacy and safety of tapinarof in the electronic databases of PubMed and Cochrane using a combination of keywords such as tapinarof, psoriasis and AhR. This review will delineate the molecular mechanisms underlying the action of tapinarof and also summarise the trial data supporting the claim that tapinarof is replacing the existing standard of care in psoriasis management.


This paper examines the extent to returns on RMB exchange rate exhibit mean and volatility asymmetries,as a response to past return of dollar/RMB exchange rate.In particular,we wish to assess the asymmetric effect,we use the Bayesian Inference and propose a double threshold non-linear GARCH model,combined with a GJR effect(i.e.,influenced by past return of non-dollar),to capture both mean and volatility asymmetric behaviours.In an application to four returns of exchange rate,clear evidence of threshold non-linearity is discovered,which shows the asymmetric behaviours under the influence of two factors.This stronger spillover effect from the U.S.and lower mean persistence are following a good news of US dollar.


The climate change characteristics of decade,annual,seasonal and monthly sunshine durations in Xining city were analyzed based on the observed data of sunshine duration in Xining city in recent 50 years.The resu1ts indicate that in recent 50 years,the sunshine duration decreased with a tendency of 75.1 h per ten years;the interannual variation amplitude is obvious;and the difference of the sunshine duration between 1963 and 2007 reaches up 635.3 h.There is obvious seasonal difference in sunshine duration,the decreasing amplitudes in summer and winter are more obvious than that of spring and autumn.The decreasing tendency is the most significant in January and less in April.The annual sunshine duration in 1983 occurred abrupt change from long to short.


Abstract A global, multi-level, baroclinic primitive equation model is used as a vehicle to test several initialization procedures for suppressing inertial-gravity noise, including static balancing on pressure and on sigma surfaces, iterative dynamic balancing with Temperaton's averaging scheme, and finally the use of a time filter. It is tentatively concluded that static balancing, followed by dynamic balancing equivalent to a 12 h forecast, and the use of a time filter will suppress gravity noise adequately for prediction purposes and may also permit nonsynoptic data to be assimilated about every 4 h without serious trauma.


In this chapter, I consider the originality and applicability of Jean-Pierre Meunier's phenomenological account of cinematic identif ication. I focus in particular on the key role assigned to imagination in his account of spectator identif ication, and describe some suggestive parallels with contemporary theorists' accounts of imagination (as perceptual engagement, mental simulation, or make-believe, and Murray Smith's threefold "structure of sympathy"). Finally, I consider some diff iculties in Meunier's model – his overly clustered concept of 'identif ication'; a tension between formal-phenomenological analysis and background cultural-historical preunderstanding; and his focus on character identif ication at the expense of background 'world' apprehension – that could be modif ied in order to enhance his original contribution to philosophical f ilm theory.


It is well known that existence and accumulation of space charge within the insulating material poses threat to the reliability in the operation of dc power cables. When the cables are loaded under high voltage direct current (HVDC), temperature gradient is developed across the insulation material. In this paper, commercial ac XLPE power cables were used under an application voltage of 80 kV dc with different temperature gradients loaded between the insulating material. Space charge distributions were then measured across the insulation of the cable by means of a modified pulsed electroacoustic (PEA) system with a current transformer attached. Therefore, a replica of a power cable under load conditions could be obtained, which allows us to investigate the formation, migration and accumulation of space charges in a power cable both without and with different temperature gradients consideration across the bulk of the insulating material. Discussion will be made thoroughly in order to understand the space charge phenomenon of power cable under its service temperature.


The crystal structure of the recently discovered heavy-fermion (HF) superconductor CeCoIn{sub 5} (T{sub c} = 2.3 K) has been determined by high-resolution neutron powder diffraction. It is tetragonal (space group P4/mmm), with lattice parameters a = 4.61292(9) {angstrom} and c = 7.5513(2) {angstrom} at ambient conditions. Whereas CeCoIn{sub 5} is isostructural with the HF aniferromagnet CeRhIn{sub 5} and the HF superconductor CeIrIn{sub 5}, its cell constants and its only variable positional parameter, zIn2, differ significantly from the corresponding ones of CeRhIn{sub 5} and CeIrIn{sub 5}. As a result, the distortions of the cuboctahedron [CeIn{sub 3}], which is the key structural unit in all three materials, are different in CeCoIn{sub 5} from the ones in CeRhIn{sub 5} and CeIrIn{sub 5}. The compounds CeCoIn{sub 5} and CeIrIn{sub 5}, which contain the most distorted (in one or another way) [CeIn{sub 3}] cuboctahedra exhibit superconductivity at ambient pressure below 2.3 K and 0.4 K, respectively. On the other hand, CeRhIn{sub 5}, in which [CeIn{sub 3}] cuboctahedra are the less distorted, and the cubic HF CeIn{sub 3} are antiferromagnets at ambient pressure with T{sub N} = 3.8 K and 10 K respectively; they become superconductors under pressure of 16 kbar and 25 kbar with T{submore » c} = 2.1 and 0.2 K respectively.« less


Among the many ways to do business, e-collaboration system is gradually widely used by virtue of its advantages. Yet, designing e-collaboration systems still proves to be a great challenge due to the incomplete and inaccurate design specifications. This paper presents a characteristic modeling approach to facilitate e-collaboration system design. This approach transforms e-collaboration requirements descriptions into four types of design models. The coordination, communication, collaboration, and connectivity characteristics of e-collaborative systems are firstly addressed in these design models. In general, these models are designed to provide a more comprehensive and accurate system specification than the original requirement descriptions. The approach intends to provide a systematical approach for modeling e-collaboration processes to support e-collaboration systems design.


Many current studies on agent-based computational finance focuses on learning and evolution.However,they ignore the intrinsic cause of agent learning-agent adaptation.The paper proposes a hiberarchy framework of agent adaptation based on agent behavior model.It discuss various mechanisms for adaptation occurring agent-based computational finance and explains the significance of exploring agent adaptation in multi agent simulation of stock market.


The chemical structure of polyethylene surface has been changed by the fluorine treatˉment.The effect of surface treatment on the space charge distributions in above sample is studied in this paper.The results show the amount of space charge in the fluorine polyethylene is more than that of the polyethylene at the same electrical field.Hole injection happened in the fluorine polyethylene under80kV/mm electrical field.


The advent of craniofacial surgery has provided the clinical investigator with a unique opportunity to study the relationship between form and function. In the pre-operative state, longitudinal studies served to define the natural history of each entity. Following the extraordinary reconstructions made possible by craniofacial surgery, changes in form and function were documented in the same patient. Three case histories are presented to illustrate three different syndromes with innovative surgical procedures developed and performed by Dr Paul Tessier.


The simplest classical observables originate from symmetry properties of a quantum system; three examples of such behavior are provided: the fermion / boson property, the mass of a "nonrelativistic...


The present state of the regional insurance market in the Republic of Mordovia is treated in the article; tendencies for its further development are analysed. Regional insurance market leaders are marked. The analysis of basic indices of the regional insurance market has been carried out; measures for its modernisation have been developed.


A new version of the Frechet model is investigated and studied. Some of its are mathematically derived. The well-known method of maximum likelihood is used in estimating the unknown parameters. The new version is much better than other important competitive Frechet versions in modeling reliability real data.


Consultant general surgeon Huddersfield Hospitals 1966-88 (b Swindon Village, Gloucestershire, 1928; q St Bartholomew's Hospital 1955; FRCS), died from cerebrovascular disease on 29 April 2005.2005.

Figure 1

Graham was senior registrar at the Leeds and Bradford teaching hospitals from 1961 to 1966 and then a progressive general surgeon in Huddersfield, embracing all aspects of general surgery, with a particular interest and expertise in breast surgery. He created a specialist breast surgical clinic in Huddersfield in 1966 and was chosen to lead one of the four breast screening units in the United Kingdom during the 1970s, which were subsequently "rolled out" through the NHS. In 1970 he was elected president of the Honley Male Voice Choir. He took early retirement after a heart attack but continued to enjoy his music and developed his hobby as a caterer. He leaves a wife, Patricia; five children; and 11 grandchildren.


The paper considers a wide class of control objects, the movement of which is described by a system of ordinary differential equations with polynomial nonlinearities from the phase coordinates of the object. Such models, called polynomial ones, are used to describe the movement of systems of various kinds: electromechanical devices, chemical reactors, aircraft, biological and ecological systems, etc. For these objects, a method is proposed for linearizing their mathematical description by expanding the state space of the object with new coordinates, representing the product of the original coordinates. The method uses the results of matrix theory with the Kronecker product, which systematize and simplify the procedure for analyzing the motion of nonlinear systems. The established relationship between the proposed iterative procedure for constructing linearized models of degree k = 2, 3,…, taking into account the effect of components of polynomial nonlinearities of degree $k$ on the object's dynamics, and the Volterra functional series describing the motion of the object under study made it possible to assess the range of applicability of linearized models and their accuracy.


(S-AM)whencultivated in thepresenceofL-methionine. Cellgrowth isinhibited bytheaddition ofhigh concentrations ofL-methionine. A numberofinvestigators haveattributed this tothedepletion ofadenosine triphosphate (ATP) asa consequenceoftheutilization ofthatmucleotide forS-AMformation. Thecellular ATP poolofSaccharomyces cerevisiae was measured during growth inhibition caused byadditionofexcessL-methionine. Polyethylenimine thin-layer chromatography and subsequent autoradiography were usedtoquantitate theextracted ATP.AdditionofL-methionine toa level of5 mg/mlina culture during exponential growth caused an increase inthedoubling timeof40to50%.During this period, thecellular ATP level continued increasing normally and,as thecells entered stationary growth, receded toa level characteristic ofan uninhibited stationary culture growth. After theaddition ofmethionine, there was neveran observed depletion oftheATP poolother thanthenormalfluctuation which occursinan uninhibited culture. Wehaveconcluded thatgrowth inhibition by excessive methionine doesnotresult fromlimiting availability ofATP.


INTRODUCTION: Monozygotic twinning, associated with increased infant morbidity and mortality, is more common after assisted reproductive technology (ART) than in the general population. Although multiple factors have been proposed as contributors, studies seeking to define causality have been underpowered or inconclusive. We evaluated trends of monozygotic twinning in ART and its association with patient and treatment factors. METHODS: We analyzed 392,136 pregnancies resulting from fresh, nondonor embryo transfers conducted between 2000 and 2011 and reported to the National ART Surveillance System. We examined trends of monozygotic twin pregnancies (defined as those in which number of fetal heart tones on first trimester ultrasound exceeded number of embryos transferred) using the Cochrane-Armitage test and subsequently compared monozygotic twins with (1) singleton pregnancies (one fetal heart) and (2) other multiple-gestation pregnancies (more than one fetal heart but not more than number of embryos transferred). Modified Poisson regression models were used to estimate adjusted risk ratios (aRRs) for monozygotic twinning association with assisted hatching for both comparison groups, stratified by day-3 and day-5 transfer. RESULTS: Incidence of monozygotic twinning after ART increased from 2000 to 2011 (P<.001 for trend), with greater incidence in day-5 (1.72%) than day-3 (0.48%) embryo transfers. Monozygotic twinning was associated with assisted hatching among day-3 embryo transfers when compared with both singleton (aRR 2.19, confidence interval [CI] 1.93–2.48) and other multiple-gestation (aRR 2.27, CI 2.00–2.57) pregnancies and among day-5 embryo transfers when compared with other multiple-gestation pregnancies (aRR 1.18, CI 1.05–1.32). CONCLUSIONS: Monozygotic twin pregnancy incidence after ART has increased over the past decade. Day-5 transfer and assisted hatching are associated with increased monozygotic twinning risk.


The rural distribution network has deteriorated. This is due to the high failure rate of electrical equipment, high maintenance costs, reduced power quality, and the increased duration of power outages in agricultural production. This leads to a short supply of electricity, downtime of processing equipment, loss of production or production of low-grade products, as well as excessive energy losses during transmission. The important issue is the development of advanced methods for assessing the feasibility and effectiveness for component replacement of power transmission equipment with newer and more modern, reducing electrical energy loss in the distribution network. To solve these problems, various strategies have been developed and studied to improve the reliability of 10 kV overhead power lines by using modern insulators, wires, and supports.


Provided are an epoxy resin composition and a use thereof. The epoxy resin composition comprises an epoxy resin containing phosphorus and bromine, and can be used for preparing a prepreg and a copper clad laminate. An epoxy resin containing phosphorus and bromine is used, and phosphorus and bromine in the epoxy resin are set at specific contents and proportions so as to obtain the epoxy resin composition. Thus the flame retardance of the epoxy resin composition can reach UL94 V-0 grade. A prepreg and a laminate prepared using the epoxy resin composition have low moisture absorption, good heat resistance, cohesiveness, reactivity and processability. Furthermore, in contrast with traditional plates of a high comparative tracking index (CTI) filled with a large amount of aluminum hydroxide, CTI greater than or equal to 600 V can be achieved with a small amount of aluminum hydroxide or without aluminum hydroxide.


The relaxation in complex systems is in general nonexponential. After an initial rapid decay the system relax slowly following a long time tail. In the present paper a sandpile modelation of the relaxation in complex systems is analysed. Complexity is introduced by a process of avalanches in the Bethe lattice and a feedback mechanism which leads to slower decay with increasing time. In this way, some features of relaxation in complex systems: long time tails relaxation, aging, and fractal distribution of characteristic times, are obtained by simple computer simulations.


Antenna high gain, wide bandwidth, reconfigurability and compact design has been long requirements in the field of mobile communications and aeronautics. This paper experimentally investigates superstrate layer of arrays placed above the dielectric resonator antenna (DRA), which can largely enhance the gain of antenna. Experimental and simulated results of gain with and without superstrate have been investigated. The superstrate arrays placed on DRA has improved the antenna gain, i.e., 8.7 dBi to 12.27 dBi. The effect of high permittivity material has been studied for gain and bandwidth improvement. Barium strontium titanate (BaSrTio3) mixed with silicon oil was used in DRA. Superstrate array have resulted into gain improvement to the extent of 28%. The design frequency was kept at 6.59 Ghz and verified theoretically using MATLAB. Height of substrate and dielectric constant affected the gain and bandwidth. Theoretical, simulated and experimental results have been compared and found in good agreement.


The goal of UML(unified modeling language) is to describe any system in the way of object-orientation,which is a general visual modelling language.The UML is introduced firstly,then application to the process of workflow management of the futures cor-poration and modelling is demonstrated by using UML with the help of RUP.


Linear and rectangular [n]rotaxanes were synthesized by template-directed clipping of heterocrown ether components onto the dumbbell-shaped molecules containing different dialkylammonium recognition sites. The effect of the structure of the dialkylammonium sites on the clipping efficiency was investigated, and selective clipping led to formation of a rectangular [4]rotaxane.


This paper explores three theoretical approaches – social structural analysis, intersectionality and Diversity Studies – and investigates how they can contribute to a better understanding of the complexity of current vertical and horizontal social differentiation. The comparative overview describes the different concepts, discusses their strengths and weaknesses before offering guidance for further analyses. In order to provide a concrete anchor for the discussion, the author uses the social category of 'dis/ability' while referring to Disability Studies as an academic discursive framework. When it comes to tackling a multifaceted social difference such as 'dis/ability', the paper demonstrates that a multi-perspective approach is most likely to yield innovative insights. Indeed, applying a social structural analysis with its emphasis on class together with an intersectional approach as well as a culturalist perspective characteristic of Diversity Studies will inevitably draw attention to the multi-dimensionality of social differentiation.


BILLET CANE, leaf, and tops form the overwhelming bulk of sugar mill feedstocks, but currently there is no accurate and reliable non-invasive method of directly estimating the amount of trash (combined leaf and tops) they contain, or distinguishing between the amounts of leaf and tops. This paper reports on a novel technique that can reliably and non-invasively distinguish between billet cane, leaf, and tops on the basis of high resolution colour imagery. The technique distinguishes between billet cane and both leaf and tops using detailed surface texture. The features distinguishing cane from leaf and tops are consistent across all cane varieties examined and do not require calibration for cane variety. Texture is not a good discriminator between leaf and tops. However, leaf and tops can be distinguished on the basis of hue since the differences in water content and degree of senescence which distinguish leaf and tops are associated with hue. Texture and hue based discriminators are then merged in a probabilistic framework to produce a combined classifier capable of achieving true positive identification rates between 80% and 90% and false positive identification rates below 10% for cane, leaf, and tops in unseen test


In this paper, we introduce a block AA T-Lanczos bi-orthogonalization process. Based on this new process, the block bi-conjugate residual (Bl-BCR) method is derived, which is also a generalization of bi-conjugate residual method. In order to accelerate the rate of convergence, we generate a stabilized and more smoothly converging variant of Bl-BCR using formal matrix-valued orthogonal polynomials. Finally, numerical experiments illustrate the effectiveness of these block methods.


ABSTRACT Biphenyl dioxygenase (BPH dox) oxidizes biphenyl on adjacent carbons to generate 2,3-dihydro-2,3-dihydroxybiphenyl inComamonas testosteroni B-356 and in Pseudomonassp. strain LB400. The enzyme comprises a two-subunit (α and β) iron sulfur protein (ISPBPH), a ferredoxin (FERBPH), and a ferredoxin reductase (REDBPH). B-356 BPH dox preferentially catalyzes the oxidation of the double-meta-substituted congener 3,3′-dichlorobiphenyl over the double-para-substituted congener 4,4′-dichlorobiphenyl or the double-ortho-substituted congener 2,2′-dichlorobiphenyl. LB400 BPH dox shows a preference for 2,2′-dichlorobiphenyl, and in addition, unlike B-356 BPH dox, it can catalyze the oxidation of selected chlorobiphenyls such as 2,2′,5,5′-tetrachlorobiphenyl on adjacent meta-paracarbons. In this work, we examine the reactivity pattern of BPH dox toward various chlorobiphenyls and its capacity to catalyze themeta-para dioxygenation of chimeric enzymes obtained by exchanging the ISPBPH α or β subunit of strain B-356 for the corresponding subunit of strain LB400. These hybrid enzymes were purified by an affinity chromatography system as His-tagged proteins. Both types, the chimera with the α subunit of ISPBPH of strain LB400 and the β subunit of ISPBPH of strain B-356 (the αLB400βB-356 chimera) and the αB-356βLB400 chimera, were functional. Results with purified enzyme preparations showed for the first time that the ISPBPH β subunit influences BPH dox's reactivity pattern toward chlorobiphenyls. Thus, if the α subunit were the sole determinant of the enzyme reactivity pattern, the αB-356βLB400 chimera should have behaved like B-356 ISPBPH; instead, its reactivity pattern toward the substrates tested was similar to that of LB400 ISPBPH. On the other hand, the αLB400βB-356 chimera showed features of both B-356 and LB400 ISPBPH where the enzyme was able to metabolize 2,2′- and 3,3′-dichlorobiphenyl and where it was able to catalyze the meta-para oxygenation of 2,2′,5,5′-tetrachlorobiphenyl.


The invention relates to the field of intelligent driving technologies, solves the problem that two vehicles merging into one lane have no language communication, and discloses a vehicle assistant driving method based on an automatic negotiation lane merging probability. The vehicle assistant driving method comprises the steps that: step 1, a present vehicle searches for nearby vehicles when trying to perform lane merging operation; step 2, a communication device of the present vehicle sends lane merging requests to vehicles which fall into a range, and finds out the nearest neighbor vehicle; step 3, the present vehicle requests the nearest neighbor vehicle to establish a point-to-point secure communication link by means of the communication device; step 4, a lane merging negotiation device of the present vehicle generates a random number alpha, the nearest neighbor vehicle generates a random number beta, and a numerical value of the random number alpha is compared with that of the random number beta; step 5, and when the negotiation is successful, a steering lamp of the present vehicle is turned on for few seconds, a double-flashing lamp of the nearest neighbor vehicle is turned on twice and the nearest neighbor vehicle decreases a driving speed, thus the present vehicle performs lane merging operation; when the negotiation is unsuccessful, the present vehicle turns off the steering lamp and drives along a current lane continuously.


Sep.2010 to Nov.2010,70 soil samples had been taken from different corn fields in Liaoning Province.More than 100 strains were gotten through different cultivation and separation methods,which have been preserved in the fungal laboratory of Shenyang Agriculture University(HMSYAU).19 Species belonging to 17 genera of soil fungi were identified,of which genus,3 species undeterminated.The results showed that the highest separation rate was that of Penicillium expansum,(28.0%).The next was Chrysosporium sp.,(12.1%),Penicillium minioluteum,(10.6%);and the lowest separation rate was that of Chaetomium brevipilium,Fusarium oxysporum,Metarrhizium anisopliae and Ramichloridium schulzeri(0.8%).Geographically,Liaozhong,Dongling,Dawa,Kaiyuan had the most quantitative distribution of fungous colony in Maize rhizosphere,in which Liaozhong had the most of 8.3×104cuf·g-1.The area of Pulandian has the least quantitative distribution of fungous colony in Maize rhizosphere,1.6×104cuf·g-1.Kaiyuan and Dawa had the most isolated fungous species(12) and the dominant specie was Penicillium expansum.The area of Dashiqiao had the least isolated fungous species(4) but the dominant specie was still Penicillium expansum.


Currently widespread in new urban projects, green roofs have shown a positive impact on urban runoff at the building/parcel scale. Nevertheless, there is no specific policy promoting their implementation neither in Europe nor in France. Moreover they are not taken into account (and usually considered as an impervious area) in the sizing of a retention basin for instance. An interesting example is located in the heart of the Paris-East Cluster for Science and Technology (Champs-sur-Marne, France). Since 2013 a large (1 ha) wavy-form vegetated roof (called bleu green wave) is implemented. Green roof area and impervious areas are connected to a large retention basin, which has been oversized. The blue green wave represents a pioneering site where an initially amenity (decorative) design project has been transformed into a research oriented one. Several measurement campaigns have been conducted to investigate and better understand the hydrological behaviour of such a structure. Rainfall, humidity, wind velocity, water content and temperature have been particularly studied. The data collected are used for several purposes: (i) characterize the spatio-temporal variability of the green roof response, (ii) calibrate and validate a specific model simulating its hydrological behavior. Based on monitoring and modeling results, green roof performances will be quantified. It will be possible to estimate how they can reduce stormwater runoff and how these performances can vary in space and in time depending on green roof configuration, rainfall event characteristics and antecedent conditions. These quantified impacts will be related to regulation rules established by stormwater managers in order to connect the parcel to the sewer network. In the particular case of the building of a retention basin, the integration of green roof in the sizing of the basin will be studied.


Equilibrium adsorption studies for detoxification of Congo Red (CR) dye from single component model wastewater by powdered watermelon rinds and neem leaves adsorbents were carried out with the view to test the applicability of the adsorption process to Langmuir, Freundlich, Temkin, Dubinin-Radushkevich and Harkins-Jura isotherm models. The values of correlation coefficient, R2 (0.9359 - 0.9998), showed that all the experimental data fitted the linear plots of the tested isotherm models. Dubinin-Radushkevich's monolayer maximum adsorption capacity qD (20.72 - 26.06 mg/g) is better than Langmuir's qm (18.62 - 24.75 mg/g) for both adsorbents with the capacities higher for adsorption on watermelon rind than on neem leaves. Values of Langmuir separation factor (RL) suggest unfavourable adsorption processes (i.e. chemisorption) of the dye on both the adsorbents, while Freundlich constant (nF) indicates unfavourable process only for CR adsorption onto neem leaves. The Dubinin-Radushkevich's mean free energy of adsorption, E (0.29 - 0.32 kJ/mol), suggests physical adsorption processes. Values for Temkin's heat of adsorption, bT (-0.95 to 0.74 kJ/mol), also show physical adsorption process.


Social capital – as reflected in inter-organizational network relations – is a widely researched phenomenon for large, mostly publicly listed firms. With respect to social enterprises, however, little is known about the importance of social capital. We aim at closing this gap by empirically analyzing the influence of various dimensions of social capital on knowledge transfer, social innovation, and, subsequently, social impact. We theorize that social capital is positively related to social innovation with knowledge transfer also acting as partial mediator. Furthermore, we suggest that social innovations are positively related to the social impact of these firms. Based on a large sample of social enterprises, the results of fitting these to a structural equation model provide broad support for these considerations.


Volume 4 of The Papers of James Monroe collects Monroe's papers and correspondence from the period 1796-1802, covering his last years as U.S. minister to France and his term as governor of Virginia.


Quark models with four-fermion interaction including derivatives of fields in the strong coupling regime are used to implement composite-Higgs extensions of the Standard Model. In this approach the dynamical breaking of chiral symmetry occurs in two (or more) channels (near polycritical values for coupling constants), giving rise to two (or more) composite Higgs doublets. Two types of models are built for which Flavor Changing Neutral Currents (FCNC) are naturally suppressed. In the first Model I the second Higgs doublet is regarded as a radial excitation of the first one. In the second Model II the quasilocal Yukawa interaction with Higgs doublets reduces at low energies to a conventional local one where each Higgs doublet couples to a definite charge current and its v.e.v. brings the mass either to up- or to down-components of fermion doublets. For the special configuration of four-fermion coupling constants the dynamical CP violation in the Higgs sector appears as a result of complexity of v.e.v. for Higgs doublets.


Objective This literature review aimed to examine literature on published studies conducted in Africa between 1994 and 2014 which examined psychosocial and cultural issues among adult people with epilepsy and their carers such as popular, folk, professional and others like community health workers who fall between the lay and professional. The objective was to describe these issues and to identify gaps in current knowledge and to suggest actions for future research. Methods Data were searched from MEDLINE, Pub Med, ERIC, Web of Science, Scopus, Cochrane Library, Africa Wide, PsycINFO, EMBASE, PASCAL, SABINET, and Google Scholar data bases. In addition, hand searches of journals such as Epilepsy & Behavior, Epilepsia, South African Medical Journal, African Journal of Disability and African Journal of Primary Health Care and Family Medicine were done. Results The findings from the analysis of forty three articles which we reviewed included quantitative and qualitative studies examining these issues in Africa. Among these articles, we found very few that used qualitative designs and those that focused on special groups such as adult women with epilepsy. In addition, there were also very few studies that examined these issues among carers from different sectors of health care as well as adults who have epilepsy, using validated instruments. Nevertheless, there were psychosocial and cultural difficulties that emerged from our review and these differed due to different types of designs used, sample population and parameters examined. Amidst these issues, there were some cultural metaphors and a range of lay terminologies for epilepsy and seizures and meanings thereof, including stigma and some medical labels such as 'epileptics' which referred to people with epilepsy. Significance Current evidence shows that little attention has been paid to the psychosocial and cultural issues affecting PWE and their carers in Africa, yet these have been reported Stellenbosch University https://scholar.sun.ac.za


The layout problem of gate matrices and one-dimensional logic arrays is composed of two major tasks: to find a permutation of gates which minimises the number of tracks required and to layout/pack gates based on the ordering. A parallel algorithm is presented in the Letter which can pack n gates within O(1) time, whereas the conventional near-optimum algorithm needs O(n2) time. The simulation results show that the increase of the problem size does not degrade the solution quality.


PLM Drives Innovation and Product Development Transformation. How can hard goods manufacturers or retailers build on the PLM use cases from other industries, and what unique value can a PLM transformation offer to them?


The implementation of the revised Lisbon strategy and new strategic document Europe 2020 require establishment of a general framework for effectiveness of a modern economy, based on high quality research and innovative products, instruments for marketization and good balance between the interests of consumers and owners, facilitating free circulation of knowledge. Technology transfer has some evident advantages and strengths. It comprises of various actors and building up of specific elements which play different roles in the transferring process. The technology transfer possesses an ability to deal with complexity of the innovation system, etc. However, there are still many deficits as barriers in effective and competitive economy such as insufficient knowledge of the opportunities for commercialization of inventions and difference in IP management approaches implemented by the industry and research organizations, etc. Technology transfer is a unique element of the innovation system aiming to overcome shortcomings of the system and to create a sustainable link between research and business communities. Technology transfer is a milestone for establishment of new types of relationships with the businesses, providing modern IPR knowledge and commercializing innovative technologies. Favorable legislation targeted at technology transfer is a prerequisite, and a new attitude towards IP rights is required, in a broad sense - a proactive role in innovation by managing IPR from research is needed.


Started from electronic information service connotation, this paper advances the new concept of the electronic information service based on quantization of user experience. Then, the user experience was classified into four levels. Furthermore, combining the three dimensions with the four experience levels, it built a user experience quantitative index system of electronic information services, and ultimately set up a user experience quantitative concept model of electronic information services. It can provide necessary theoretical basis and practical guidance for further empirical research.


Recent advances in mass spectrometry have facilitated chemical characterization and profiling of complex environmental mixtures such as oil sand process-affected water (OSPW) and identification of previously unresolved chemicals. However, because OSPW is a complex mixture of salts, metals, suspended particulate matter, and dissolved organics, extraction techniques are required to reduce the effects of signal suppression/enhancement. In this work, Orbitrap, ultrahigh resolution mass spectrometry was used to perform a comprehensive comparison of solid phase extraction (SPE) and liquid–liquid extraction (LLE) techniques on profiling of dissolved organic chemicals in OSPW. When operated in negative ion mode, extraction of naphthenic acid (NAs–O2) was dependent on acidification of OSPW samples for C18 and LLE techniques. However, when applying a hydrophilic lipophilic balance (HLB) sorbent (ABN) SPE technique, the extractability of NAs was independent of pH. When operated in positive ion mode, for all extracti...