Objective To understand the current situation of laboratory biology safety of blood collection and supply departments in Chongqing,before and after the establishment of the laboratory biology safety management system.Methods To compar the biology safety level before and after the establishment of the laboratory biology safety management system in the blood collection and supply departments of Chongqing,and to statistically analyze the date by t test.Results The total scores of laboratory in each unit were 70.10±16.84 and 89.35±10.34.It indicated that there was statistical difference in test results.Conclusion The current situation of laboratory biology safety of the blood collection and supply departments in Chongqing is not in a good state.The government should give more support to improve the hardware and software of laboratories.


Knowledge on surface potential dynamics is crucial for understanding the performance of modern-type nanoscale devices. We describe an electrical pump-probe approach in Kelvin-probe force microscopy that enables a quantitative measurement of dynamic surface potentials at nanosecond-time and nanometer-length scales. Also, we investigate the performance of pump-probe Kelvin-probe force microscopy with respect to the relevant experimental parameters. We exemplify a measurement on an organic field effect transistor that verifies the undisturbed functionality of our pump-probe approach in terms of simultaneous and quantitative mapping of topographic and electronic information at a high lateral and temporal resolution.


Cancer is the second cause of death in the world. 8.8 million patients died due to cancer in 2015. Breast cancer is the leading cause of death among women. Several types of research have been done on early detection of breast cancer to start treatment and increase the chance of survival. Most of the studies concentrated on mammogram images. However, mammogram images sometimes have a risk of false detection that may endanger the patient's health. It is vital to find alternative methods which are easier to implement and work with different data sets, cheaper and safer, that can produce a more reliable prediction. This paper proposes a hybrid model combined of several Machine Learning (ML) algorithms including Support Vector Machine (SVM), Artificial Neural Network (ANN), K-Nearest Neighbor (KNN), Decision Tree (DT) for effective breast cancer detection. This study also discusses the datasets used for breast cancer detection and diagnosis. The proposed model can be used with different data types such as image, blood, etc.


The increasing prevalence of bacterial resistance calls for special attention since it restricts the number of available therapeutic options. The aim of this...


Research aim: The objective of research was to present the influence of strength training on selected systems of human organs on the basis of available literature on the subject. Methodology: A review was conducted of international literature based on analysis of selected articles available at Google Scholar, PubMed, SciCentral. Results: Changes in the human body as a result of both strength exercises and training were demonstrated based on analysis of the available literature. Summary: The results and the rate of benefiting from the practive of strength disciplines largely depend on gender, genetic characteristics, age, training history, health status, diet, lifestyle, current physical activity and stress levels.


The aim of this paper was to determine the dominant rainfall cycles in Adamawa State of north - eastern Nigeria. This was necessitated by the devastating flood events that occasionally ravage the area destroying lives, farmlands and property. In spite of this frequent hazard, research of erratic rainfall events in the area have remained scanty. Thirty five (1977 - 2011) years rainfall data were used to calculate the order of importance, cycles and periodicities of rainfall of the area. The technique employed to achieve this is the Harmonic Analysis which was used to mathematically express the complex fluctuations usually observed in the time series trend. Result shows that four cycles namely 1,5,10 and 13 with amplitudes of 162.21mm, 129.40mm, 124.66mm and 120.22mm and periodicities of 35, 6.20, 5.40 and 3.30 respectively were dominant. All calculations were performed with the aid of SPSS version 20 statistical program. Following from the findings, it is suggested that relevant authorities should use the result obtained to alert the populace in the area on the probability of flood in any identified year, while a comprehensive flood management plan for the area should be developed. With these measures, we hope that the devastating effect of flooding in that part of the country will be greatly minimised.


.......................................................................................................................................... vi Chapter 1: Introduction ................................................................................................................... 1 1.1. What is Plasma? .................................................................................................................... 1 1.2. Types of Plasma .................................................................................................................... 2 1.2.1. Equilibrium or Thermal Plasma ..................................................................................... 2 1.2.2. Non-Equilibrium or Non-Thermal Plasma .................................................................... 3 1.3. Methodology of generation of plasma discharges ................................................................ 4 Chapter 2: Background and Motivation .......................................................................................... 8 Chapter 3: The Gliding Arc Discharge ......................................................................................... 11 Chapter 4: The Magnetic Gliding Arc (MGA) .............................................................................. 14 4.1. Principle of the Magnetic Gliding Arc ................................................................................ 14 4.2. Design and Operation of MGA ........................................................................................... 15 4.3. Magnetic Field Strength (B) .............................................................................................. 17 4.4. Rotating Plasma Disk and Quasi-Uniformity ......................................................................... 18 4.5. Power Supply ...................................................................................................................... 20 Chapter 5: Experimental Characterization of the MGA ................................................................ 22 5. 1. OH (AΣ, υ=0 XП, υ'=0) Spectrum for Rotational Temperature ................................ 22 5. 2. The N2 Spectrum (C – B) for Rotational and Vibrational Temperature ............................ 25 5. 3. Electric Field in MGA plasma arc ..................................................................................... 27 iii 5. 4. Average Electron Energy Estimations ............................................................................... 29 5. 5. Current Density Estimations .............................................................................................. 29 5. 6. Electron Density Estimations ............................................................................................. 31 5.7. Voltage – Current Characteristics ....................................................................................... 32 Chapter 6: Discussion and Conclusions ......................................................................................... 33 Chapter 7: Bibliography ................................................................................................................. 36


SKOS is a data model to represent and network knowledge organization systems (thesauri, classification systems, etc) in RDF. SKOS is meant to be as easy of use as possible, fitting existing practices while keeping general enough to fit a high number of use cases and KOS configurations. In this tutorial, an introduction to the various features of SKOS will be given, illustrating how they can be used to represent existing KOS data. The tutorial will present how the vision of leveraging existing KOS on the web of data is being adopted in a number of projects, in the Cultural Heritage sector and beyond. Available tooling and methods for creating and publishing SKOS as well as porting legacy KOS data to SKOS will also be discussed.


Thromb Haemost 2009; 101: 993–994 Toll-like receptors (TLR) constitute a protein family of 13 different mammalian subtypes of heterodimeric immune receptors which are activated by a diverse range of molecules specific to certain microbial hazards. Among them, TLR subtype receptor 3 (TLR3) is unique because it is activated by double-stranded RNA (dsRNA) of viral pathogens. Polyinosinic:polycytidylic acid (poly I:C) serves as a well-known activator of TLR3 in cell culture studies to mimic the agonistic effect of dsRNAs (1). In general, TLRs are expressed on immune cells of monoblastic or myeloblastic origin, such as dendritic cells, lymphocytes or monocytes and play a pivotal role in innate immunity. Moreover, certain TLRs have been described on certain epithelial cell types and in particular TLR3 was found to be present on epithelial and neuronal cells, in the kidney and also on mesothelial cells (2–5). In contrast to most TLRs, signalling of TLR3 is independent of the common TLR adaptor protein MyD88 but involves the adaptor protein Trif (TIR-domain-containing adapter-inducing interferon-β, TICAM-1), which ultimately induces transcriptional activation of interferon-α and -β, both of which play a substantial role in the inflammatory immune response following viral infections. In this issue of Thrombosis and Haemostasis, Wornle et al. describe a novel link between viral infection of serosal cavities and regulation of fibrin generation and fibrinolysis (6). In a cell culture model of mesothelial cells isolated from explanted human omental tissue, they show that stimulation with poly I:C leads to both a concentration-dependent increase of plasminogen activator inhibitor 1 (PAI-1) synthesis and a concentration-dependent decrease of tissue plasminogen activator (t-PA) synthesis. Aside from TLR3, mesothelial cells also express the helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5),which may also act as sensors of viral infections through recognition of viral dsRNA and may up-regulate type I interferons. The specifity of the involvement of TLR3, RIG-I and MDA5 in these observations is confirmed by the use of RNA interference technology. These results indicate that the effect of poly I:C on increased PAI-1 but decreased t-PA synthesis is mainly mediated by TLR3. The authors interpret their findings to be of potential importance for the pathogenesis of viral diseases in serous tissue such as the mesothelium, pleura or pericardium because fibrin deposition at these sites could be promoted through the described mechanism. This could ultimately determine the course of the infectious disease e.g. by leading to pleural or pericardial fibrosis. In the mesothelium, similar mechanisms may be responsible for the failure of the peritoneal space to contribute to permeability changes. Hence, in this specific context, activation of mesothelial viral receptors followed by disturbance of the fibrinolytic system could explain why patients undergoing chronic abdominal peritoneal dialysis only profit from this type of treatment for a limited time span. From the data obtained by Wornle et al., such conclusions seem straightforward and comprehensible, yet another implication of the findings presented in this work could be related to the change in gene expression of adjacent vascular tissue. Since under guiescent conditions in vivo the ratio in gene expression between t-PA and PAI-1 in vascular endothelium is very high, poly I:C could dramatically shift this value resulting in the upregulation of PAI-1. This would lead to a more prothrombotic cellular phenotype as recently documented by the poly I:C induced up-regulation of tissue factor and down-regulation of thrombomodulin in the vessel wall (7). Indeed, increased levels of t-PA and PAI-1 have long been known to be present in the early stages of atherosclerosis and to be independent risk predictors for myocardial infarction (8, 9). However, according to present data, they seem to be markers of increased endothelial activation rather than playing an active role in promoting atherosclerosis (10). Intriguingly, besides being expressed in the above mentioned tissues, TLR3 also appears to be expressed on cells of the vascular endothelium, where it most likely acts as a receptor for viral dsRNAs. Thus, activation of endothelial innate immune receptors such as TLR3 could actually represent an active promoting mechanism in atherosclerosis and its thrombotic complications because it might not only result in dysregulation of the t-PA-PAI-1 system, but could also activate other signalling pathways within endothelial cells that directly promote endothelial dysfunction. Indeed, in a very recent report by Fischer et al., the authors describe endothelial activation through extracellular RNA (but not DNA) leading to binding of vascular endothelial growth factor (VEGF) to neuropilin-1, © 2009 Schattauer GmbH, Stuttgart


Effects of a small functional group, cyano, on the supramolecular polymerization of fan-shaped monomers were investigated. When cyano groups are replaced by hydrogen atoms, the resultant monomers surprisingly fail to undergo supramolecular polymerization and exist as monomers in methylcyclohexane (MCH). Moreover, in the mixed monomer systems, we successfully visualized a small difference in the self-assembling behaviors, which was dependent on the number of cyano groups.


The aim of this study was to compare the effectiveness of semaglutide versus liraglutide for treating post‐metabolic and bariatric surgery (MBS) weight recurrence.


M A N Y authors have reported the occurrence of extrachromosomal inheritance in microorganisms, animals, and plants. The following are examples of this phenomenon found in Drosophila: CO, sensitivity in D. melanogaster 1958); mutator activity in D. persimilis sex ratio condition in D. bijasciata male sterility D. chromosomal aberration an infectious lethal agent which segregation distortion Genetics, Japan). These stocks were maintained in our laboratory at 25°C. Since 1965, a distorted ratio has appeared constantly in the cross of bwD/bwD females with certain Cy heterozygous males although the magnitude of distortion has fluctuated appreciably. Out of 178 wild second chromosomes examined in 1966, 10 chromosome lines showed ratio distortion when they were heterozygous with Cy in males and were crossed with bwD/bruD females. In the present study, three chromosome lines out of these ten were used and denoted by S-5, S-7 and S-9 strains. The S-5 chromosome was recessive lethal, while the other two were quasinormal when homozygous. These three strains and other wild chromosome strains employed carried the cytoplasm of the Cy/Pm strain.


This paper expounds the measure for determining the location of the mined -out area by suing the geophysical survey method, SYT natural electromagnetic wave method, and through three different processing modes, obtains corresponding geological maps, and makes analysis and research on them, and thus determines the location of the mined-out area on the surface.


MWM: Joseph, I'm curious, in reading Coomaraswamy now?an article he wrote in the late twenties or early thirties ? what use would his evidence from India have been to you in writing On Adam's House in ParadiseV JR: It would have been invaluable, because there was no material on the pre-Gupta architecture of India then available to me. Very few things had been written about it, most of them by Coomaraswamy himself. Very thin, and I simply couldn't get at the sources on sacred literature that I needed for Indian material, not being a Sanskrit speaker or reader, so I relied on people who wrote in European languages, and this particular issue?the issue of the primitive hut as a model of permanent architecture?had simply not been treated. It's really rather surprising to me that Coomaraswamy didn't publish his material in his lifetime. MWM: My impression, from reading On Adam's House in Paradise, had been that it was not so much the hut itself but the idea of the primordial hut that was of enormous importance to the development of European architecture and thinking about architecture. Do you think that is parallel to the situation Coomaraswamy describes for India? JR: Yes. The primordial hut is, of course, not any particular hut that anyone ever has discovered because by definition it cannot be discovered. Hence my Proustian tag at the beginning of On Adam's House in Paradise that "all paradises are lost paradises." Inevitably it was the idea of the hut that I was concerned with and, of course, the reconstruction of primitive huts ? particularly reconstructions for ritual purposes, such as the permanent primitive hut of Romulus in Rome or the temporary primitive huts which were erected for festivals such as the Jewish festival of tabernacles and the Roman festival of Anna Perenna. This kind of ritual building of deliberately primitive huts is an extremely important aspect of the religious rites and beliefs of certain peoples, and I suspect that it was something that was very important in India as well. MWM: Coomaraswamy relates the primitive hut?the hut of the hermit or the ascetic?to what he calls the "tabernacle of the flesh" and sees the hermit in his hut, I think, as equivalent to the religious aspirant or to the soul of man, which is released, at the end of his religious life, literally from the top of the skull, and Coomaraswamy relates the dome of the hut to the skull.2 Is there anything parallel to that in the West? JR: Oh, innumerable instances. The obvious one that comes to mind is the Capitolium, "the place of the skull," which was, as it were, the head of Rome. It was called that because a skull was found on the site and from the skull the prophecy was derived about the future greatness of the city of Rome. That's only one of very, very many instances. There's of course the whole history of the way in which we contend with columns, are concerned with the image of the body in columns, and particularly with the identification of capital with head. Again, "Capitolium" in Rome and the "capitendum" of the column are obviously parallels. MWM: Coomaraswamy's article, the one we are publishing for the first time, is very much involved with gritty details of scholarship?with the fragments of references in texts and fragments of representations in reliefs that Coomaraswamy could collect by sifting through vast amounts of material. In another article, however, which he wrote almost eight years later, he deals, not with the construction or structure of the dome, but with its essence, with its meaning.3 This is a remarkable article that never talks about space, never talks about keystones, never talks about arches or any other of the things that we might wish to deal with in reference to construction. He deals only with the symbolism, and yet that symbolism in India he believes is rooted in something so primitive as the hut. From that essential prototypic symbolism comes, in Coomaraswamy's mind, a whole evolution of many varied forms of sacred architecture in India. Does the


Objective To prepare nitrendipine solid dispersion pellets by centrifugal granulation technology.Methods Take micromeritical properties,yield percentage and drug dissolution rate of pellets as main index,formulation factors of varieties and content of soluble and insoluble carriers,and technology factors such as quantity and ethanol concentration of the wetting agent,centrifugal speed and time were investigated by means of the influence factors test.Physical states of drug in pellets were characterized using X ray diffraction analysis(XRD) and differential scanning calorimetry(DSC).Results Using 70% ethanol as the wetting agent,pellets composing of nitrendipine(10%),poloxamer F68(20%) and low-substituted hydroxypropylcellulose(70%) prepared at a centrifugal speed of 300 r/min for 30 min were more preferable than others,and percentage of drug dissolved in which in the first 10 min was more than 86%.XRD and DSC tests showed the presence of diffraction peaks in pellets and absence in solid dispersion,which suggested that amorphous nitrendipne in solid dispersion was crystallized in the process of pellets preparation.Conclusion Nitrendipine solid dispersion pellets prepared by centrifugal granulation technology has a structure of solid dispersion and property of immediate-releasing.


The reform of the education system in the independent Uzbekistan due attention to the content of the form of education because of the attention has been updated. Since 1997 a national training program introduced. Today, these programs have been introduced in our country after United States and other countries recognized. Strengthening the material – technical base of higher education institutions, and measures to improve the quality of training of highly qualified professional, laid the groundwork to change the contents of the knowledge and institutions of higher education. In this article the independent years of Republic Uzbekistan in the field of education reform and in this sector reached diminishing, the training of national acceptance, eyes objectless and 12 years without charge and compulsory universal education the modernization of public education achievements the status of cooperation with higher educational institutions in the developed nations of the world about said in this article.


This appendix discusses the NoC analysis, optimization and evaluation tools used while preparing this book. We first present the NoC performance analysis, architecture optimization and voltage-frequency island synthesis tools. Then, we present the simulator used to evaluate these tools. Finally, we provide a brief overview of the NoC prototypes implemented to demonstrate and evaluate our major contributions.


Dokan is a multipurpose dam located on the Lesser Zab River in the Iraq/Kurdistan region. The dam has operated since 1959, and it drains an area of 11,690 km2. All reservoirs in the world suffer fr ...


Abstract:This article interprets the central erotic triangle between Lily Bart, Lawrence Selden, and Simon Rosedale in The House of Mirth (1905) as a modernized restaging of the love triangle in Madame de Lafayette's La Princesse de Clèves (1678). Through the lens of the seventeenth-century French novel, which Wharton characterized as inaugurating the debut of "modern fiction" in The Writing of Fiction, readers can see how Wharton condemns, in The House of Mirth, the stated motivations of its characters as fundamentally unreliable and their attempts at self-knowledge as futile. In this way, both novels highlight epistemological failures—whether about love, friendship, or status—when characters falter just on the brink of attaining their desires. The last part of this study examines Rosedale's love for Lily, his active care for her, and his jealousy, which have not received adequate scholarly attention, as well as proposes a new reading of Lily's rejection of Rosedale's last marriage proposal.


Scope of the research initiative "Jena Cell Identification Group" (JenZIG) is the combination of Raman spectroscopy with optical trapping and microfluidic chips for cell identification and sorting. Using upright microscopes, fluidic connections were realized at the bottom side [1]. Cells tend to sediment in the tubing at low flow rates which is problematic for a continuous and stable injection of single cells. The contribution presents an in-house built inverted microscope to solve the problem. The performance of the new microscope was characterized for the distinction of breast carcinoma derived tumor cells (MCF-7, BT-20). The inverted microscope consists of fiber ports for coupling the excitation laser and the spectrograph with CCD detector. This enables to connect the microscope to a commercial Raman system, here HoloSpec RXN1 (Kaiser Optical Systems). Laser line filter, beamsplitter, objective holder and notch filter were installed in a 30×30 mm cage system (Thorlabs). Optical components were selected for high throughput. Comparison with the standard Leica microscope (Microprobe, Kaiser) showed almost same signal intensities. Cells were transferred into a small sample chamber with a quartz coverslip. 150 Raman spectra were collected per cell type with the inverted microscope and 50 Raman spectra per cell type with the Leica microscope using an oil immersion objective 100×/1.25. Data sets were analyzed R [2] using the package hyperSpec [3]. Classification models were developed based on partial least squares projection followed by linear discriminant analysis (PLS-LDA). Out-of-bootstrap [4], a resampling scheme comparable to iterated cross validation, was used for validation. Classification performances are discussed for data sets collected on four days. Data from both microscopes gave similar accuracies for distinction of MCF-7 and BT-20 cells. Further experiments will be performed in quartz microfluidic chips using more different cell types [1].


An efficient procedure is elaborated for the Re-catalyzed amination of alcohols (I) and (IV) with anilines (II) under CO atmosphere.


ABSTRACT Shigeru Ishiba is a heavyweight in Japan's Liberal Democratic Party and served as Defence Minister from 2007 to 2008. In this interview, he shares his views on the role of nuclear weapons in US–Japan alliance and Japan's security policy. Especially, he put emphasis on the need to ensure that extended deterrence by US nuclear weapons is always credible, while he acknowledges the miseries of nuclear weapons. In the face of growing threat of North Korea's nuclear and missile programme, Ishiba also noted that Japan's policy of not allowing the introduction of nuclear weapons in its territory should be re-examined, effectively casting doubt on the third pillar of the Three Non-Nuclear Principles. Missile defence is another item that he thinks must be strengthened to enhance the credibility of nuclear deterrence. He went on to praise Japan's plutonium policy as this constitutes 'potential nuclear deterrence' for Japan.


Today, in order to reduce fossil fuel consumption and thereby reduce greenhouse gas emissions, internal combustion vehicles with electric vehicles can replace the connections are .However, increasing the likelihood of new problems for the power grid, electric vehicles fleet is forecast Such that it coincides with the peak load of the electric vehicle charging network cited. In this paper, aggregator Electric vehicle with knowledge of the number of cars in the parking lot and the amount of charge stored in the battery electric vehicles and compliance with all provisions of the parties' agreement to participate in the energy marketAnd provides income for themselves and their car owners. To solve the problem together leading entity planning to participate in the energy market definition and assessment of scenarios has been used.


The utility model belongs to a shock damping frame for a vehicle seat. The shock isolator for a vehicle seat is composed of a seat cushion frame, a scissor-shaped arm, a shock damper, a damping spring, a lever and a manual type or an automatic type force arm regulating mechanism. The shock damping frame for a vehicle seat is characterized in that the damping spring can manually or automatically slid or lock along the lever, so the force arm of elastic force of the damping spring to the lever is changed to be balance to the weight of passengers. The utility model is easy to balance. For passengers with different weight, the utility model can automatically or easily manually complete the balance adjustment within a larger weight range without changing the pulling force of the damping spring. In addition, the manual type force arm regulating mechanism can also adjust the height of a seat.


Abstract We take a complex systems approach to investigating experimentally the collective dynamics of a network of four self-excited thermoacoustic oscillators coupled in a ring. Using synchronization metrics, we find a wide variety of emergent multi-scale behaviour, such as (i) a transition from intermittent frequency locking on a $\mathbb {T}^{3}$ quasiperiodic attractor to a breathing chimera, (ii) a two-cluster state of anti-phase synchronization on a periodic limit cycle, and (iii) a weak anti-phase chimera. We then compute the cross-transitivity from recurrence networks to identify the dominant direction of the coupling between the heat-release-rate ($q^{\prime }_{\mathbb {X}}$) and pressure ($p^{\prime }_{\mathbb {X}}$) fluctuations in each individual oscillator, as well as that between the pressure ($p^{\prime }_{\mathbb {X}}$ and $p^{\prime }_{\mathbb {Y}}$) fluctuations in each pair of coupled oscillators. We find that networks of non-identical oscillators exhibit circumferentially biased $p^{\prime }_{\mathbb {X}}$–$p^{\prime }_{\mathbb {Y}}$ coupling, leading to mode localization, whereas networks of identical oscillators exhibit globally symmetric $p^{\prime }_{\mathbb {X}}$–$p^{\prime }_{\mathbb {Y}}$ coupling. In both types of networks, we find that the $p^{\prime }_{\mathbb {X}}$–$q^{\prime }_{\mathbb {X}}$ coupling can be symmetric or asymmetric, but that the asymmetry is always such that $q^{\prime }_{\mathbb {X}}$ exerts a greater influence on $p^{\prime }_{\mathbb {X}}$ than vice versa. Finally, we show through a cluster analysis that the $p^{\prime }_{\mathbb {X}}$–$p^{\prime }_{\mathbb {Y}}$ interactions play a more critical role than the $p^{\prime }_{\mathbb {X}}$–$q^{\prime }_{\mathbb {X}}$ interactions in defining the collective dynamics of the system. As well as providing new insight into the interplay between the $p^\prime_{\mathbb{X}}\text{--}p^\prime_{\mathbb{Y}}$ and $p^\prime_{\mathbb{X}}\text{--}q^\prime_{\mathbb{X}}$ coupling, this study shows that even a small network of four ring-coupled thermoacoustic oscillators can exhibit a wide variety of collective dynamics. In particular, we present the first evidence of chimera states in a minimal network of coupled thermoacoustic oscillators, paving the way for the application of oscillation quenching strategies based on chimera control.