Introduction:
 Cardiac pacing can be created by myocardial delivery of TBX18. However, evidence for overt fibrosis at the injection site and the use of viral vectors impede clinical translation of this concept. We hypothesized that non-viral gene transfer of TBX18 combined with prevention of fibrosis with a Tgfβ inhibitor enables durable ventricular pacing in the porcine model of CAVB.

 Methods:
 All pigs underwent transvenous RF ablation of the AV node to achieve complete heart block on day-1. The pigs were implanted with a backup pacemaker (VVI=50 bpm) and with osmotic pumps designed to release A83-01, an inhibitor of Tgfβ receptors. Synthetic mRNA encoding either TBX18 (n=7) or GFP (n=2) in saline was injected in the high interventricular septum with a NOGA-MYOSTAR™ catheter. Continuous and ambulatory ECG, blood pressure (BP) and activity were recorded for the 4-week study period with telemetry.

 Results:
 The control pigs were dependent on backup pacing throughout 4 weeks with retrograde conduction from the RV apex. In contrast, TBX18 injected pigs showed higher heart rate (HR) compared to control (4-week mean HR of 58±7 vs 52±7,
 p
 <0.05), exhibiting antegrade conduction from the high septum with narrow QRS complexes. Max. HR was higher in TBX18 pigs compared to control with a 4-week average of 70±9 vs 55±11 bpm (
 p
 <0.05). TBX18 pigs exhibited diurnal HR oscillations that directly correlated with their physical activity, indicating chronotropic competence. Likewise, mean BP correlated tightly with mean HR in TBX18 injected pigs (
 p
 <0.01) but not in control (
 p
 =0.164), indicating superior hemodynamic measures. Radiopaque agent-enabled, real-time fluoroscopic visualization revealed that the injected biologic spread beyond the intended delivery site in 2 of 7 TBX18 pigs. The mean and max. HR of the 2 pigs were slower than the other five TBX18 pigs, suggesting that conventional imaging can be leveraged to identify redosing criteria, and minimize non-responders. No increase in spontaneous or induced arrhythmias was observed in TBX18 pigs compared to control.

 Conclusions:
 mRNA delivery of TBX18 combined with Tgfβ inhibition achieved durable septal pacing for 4 weeks in a porcine model chronic heart block, demonstrating therapeutic efficacy with greater safety profiles.


Aim: To study the outcome of one stage correction of developmental dysplasia of hip (DDH) in children older than three years of age Methods: This prospective study was carried out at Orthopaedic and spine unit of Hayatabad Medical complex, Peshawar from July 2007 to December 2014. With non-probability consecutive sampling technique, a total of 28 hips with DDH in 22 children of age more than 3 years (03-08) were included in the study. All the patients were managed with primary one-stage triple procedure including open reduction of the hip joint, pelvic and femoral osteotomy and were followed for a minimum of one year. Modified McKay's criteria was used for the clinical evaluation. The degree of dislocation of the femoral head was assessed by Tonnis classification system. Severin's grading system was used for Radiographic evaluation, Salter classification system was used for assessment of avascular necrosis. Results: A total of 22 patients (28 hips) were operated for developmental dysplasia of the hip. The mean age of the patients at the time of ward admission was 4.4 years. The mean follow-up period was 23 months. The average acetabular index pre operatively was 42 degrees and it to 28 degrees postoperatively. According to Modified Mackay's scoring system system 14 (50%) Hips were excellent (stable hips with pain free full range of motion, no limp and negative trendeleburg sign), 09(32%) hips were good, 03(11%) hips were fair and 02 (07%) hips were poor. Conclusion: One stage, triple procedure of open reduction, femoral shortening and Salter osteotomy is a very safe and effective method for the treatment of DDH in older children.


Objective: Our aim was to evaluate the application of clinical criteria used by the family physician for prescription of antibiotics for acute diarrheal dis...


There is no subject of more importance to the ratepayer than what is to be done with our insane poor. Whether insanity itself be on the increase or not, it is hard to say at present; but there can be no question that the number of those for whom inspectors of poor have to provide accommodation is annually so, and in all probability will be so for some time to come; for as civilisation advances, the helpless and repulsive condition of the village "natural" is more and more apparent, and the people look with increasing complacency every year on his being transferred from the dirt and degradation of the gutter to the warm and comfortable wards of the District Asylum. Nor is this the only source from which the increase arises. A great number of the insane poor are paupers only because they are insane; they belong to a class, the members of which, when in good health, are able and proud to provide for themselves; but whereas, when afflicted with bodily diseases they go to the infirmaries, and subsist on charity, when labouring under insanity they are obliged to go on the parish, and so help to crowd the County Asylums. There are other causes also at work, which, however, it is not the purpose of this paper to describe. But from


In order to seek for the effective, inexpensive and safer methods and technologies to shuck the adductor muscle from Scallop in Shell, the water jet technology is introduced and its experimental study was carried out. The nozzle is critical component in shucking device and nozzle parameters, such as cone angle φ, outlet diameter d and outlet length S, would affect the flow velocity distribution. In order to determine the influence of nozzle parameters and optimize the nozzle structure, the simulation analyses for scallop stripping equipment nozzle internal flow field are conducted. The narrow-angle fan nozzle's internal flow field was simulated using standard ε − k turbulence model with CFX software. After comprehensive analysis, the optimal parameters combinations of the nozzle for water jet processing were obtained. The result of this research has very important application value for the design and optimization of scallops shelling device.


Nonlinear filters are often very computationally expensive and usually not suitable for real-time applications. Real-time navigation algorithms are typically based on linear estimators, such as the extended Kalman filter (EKF) and, to a much lesser extent, the unscented Kalman filter. The Iterated Kalman filter (IKF) and the Recursive Update Filter (RUF) are two algorithms that reduce the consequences of the linearization assumption of the EKF by performing N updates for each new measurement, where N is the number of recursions, a tuning parameter. This paper introduces an adaptable RUF algorithm to calculate N on the go, a similar technique can be used for the IKF as well.


After investigating definitions of mathematics, this paper deals with the sort of mathematics, interpretation of mathematics and uses of mathematics. Mathematics as an universal method for scienctific research is very important. The evolution of its definition shows us that mathematics is being perfected.


We consider two different types of bounded height condition for semigroups. The first one originates from the classical Shirshov's bounded height theorem for associative rings. The second which is weaker, in fact was introduced by Wolf and also used by Bass for calculating the growth of finitely generated (f.g.) nilpotent groups. Both conditions yield polynomial growth. We give the first two examples of f.g. semigroups which have bounded height and do not satisfy any nontrivial identity. One of these semigroups does not have bounded height in the sense of Shirshov and the other satisfies the classical bounded height condition. This develops further one of the main results of the author's paper (J. Algebra, 1993) where the first examples of f.g. semigroups of polynomial growth and without nontrivial identities were given.


Preface: Introduction CHAPTER 1. THE STRIP-METHOD OF TRANSFORMATION OF SIGNALS 1.1. The strip-method linear encoding, and problems solved by it 1.2. Conservation of a smoothness of the transformed signal 1.3. Alignment of a variance of a non-stationary signal 1.4. Alignment comprehension a non-stationary signal 1.5. Spectrum narrowing of an encoding signal CHAPTER 2. OPTIMAL CHEBYSHEV ENCODING AND THE FILTRATION 2.1. Preliminary remarks 2.2. Problem statement 2.3. An estimation of a potential noise-immune in case of single pulse noise 2.4. An estimation of a potential noise-immune in case of multiple pulse noise 2.5. Synthesis optimal Chebyshev filter 2.6. Quasi-optimal encoding 2.7. Redundancy introduction in a strip-method linear encoding CHAPTER 3. THE STRIP-METHOD OF TRANSFORMATION OF IMAGES 3.1. A two-dimensional strip-transformation 3.2. A choice of optimal matrices of transformation 3.3. Examples of strip-transformation of images 3.4. Definition of critical multiplicity of pulse noise 3.5. Root images of bilateral strip-transformation CHAPTER 4. HARDWARE REALIZATION OF THE STRIP-METHOD 4.1. Realization of a strip-method with use of magnetic recording-reproduction 4.2. Realization of a strip-method with a cyclic matrix 4.3. The device of alignment of a signal variance 4.4. Devices for introduction of information redundancy Conclusion Appendix. Hadamard matrices and matrices close to them Bibliography.


The papers contain correspondence and other materials documenting the efforts of Ralph gibbs Van Name to publish technical and biographical work on Josiah Willard Gibbs, the scientist who developed th


in: Dissertation Abstracts International A 75,7(E), Jan. 2015. This research focuses on singable translating in the Cantonese dubbed version of Disney animated musicals, one of the most complicated – but at the same time one of the most neglected – translational activities. The present research is a pioneer attempt at an in-depth study of the relationship between the target text and four major components of the multimedial presentation respectively, namely, the source music (one-melody relationship, the time-related elements, and rhyming), the source text (semantic fidelity, semantic deviation and semantic anomaly), the source images (word-image relationship), and the target viewer (immediate comprehensibility), hoping to shed new light on this complicated yet neglected translational activity. A viewer-oriented approach for translating dubbed songs into Cantonese is identified. Cheng, Xingwang: Zǎoqí zhōngguó dònghuà diànyǐng yīnyuè jíqí lìshǐ dìwèi. In: Zhōngyāng Yīnyuè Xuéyuàn xuébào 115,2, 2010, S. 53–62. [Musik im frühen chinesische Animationsfilm und ihr historischer Status.] The first Chinese animated film music was that for the short Luotuo xianwu ("Dancing Camel") in 1935, around the time when sound films (made in China from 1930) began to dominate the market; the first phase of animated film music in China lasted until 1949 as a period of initial exploration and limited development. During these 14 years, it engaged with the anti-Japanese War and subsequent Civil War, and its relation to society should not be neglected; it was also associated with the exploration of other elements in film making (language, scene, etc.) at the time. He Lüting's score for an animation sequence inserted into Yuan Muzhi's Dushi fengguang ("Scenes of City Life", 1935) was the first piece of creative music used with animation in China. The peak of the early period was Lu Zhongren's music for China's first animated feature, Tie Shan gongzhu ("Princess Iron Fan"), directed by the Wan brothers (Wan Guchan and Wan Laiming) in 1941. Chusid, Irwin: Raymond Scott, Accidental Music for Animated Mayhem. In: The Cartoon Music Book. Musik im Animationsfilm // Medienwissenschaft, 164, 2016 /// 14 Ed. by Daniel Goldmark & Yuval Taylor. Chicago, IL: A Cappella Books 2002, S. 151–160. Even though Scott (1908–94) himself never wrote a score for an animated feature, his programmatic late-1930s novelty jazz instrumentals have been used in countless cartoons. Cipolloni, Marco: "Como un pequeño ciclón": La lunga corsa di Speedy Gonzales, tra connotazione linguistica, musica e pubblicità. In: Dubbing Cartoonia: Mediazione interculturale e funzione didattica nel processo di traduzione dei cartoni animati. A cura di Gian Luigi De Rosa. Casoria (Napoli): Loffredo University Press 2010, S. 29–45. (Margens: Oltre la traduzione.1.). Clague, Mark: Playing in 'Toon: Walt Disney's "Fantasia" (1940) and the Imagineering of Classical Music. In: American Music: A Quarterly Journal Devoted to All Aspects of American Music and Music in America 22,1, Spring 2004, S. 91–109. Examines the innovations in recording and photography with the 1940 production of "Fantasia," by Walt Disney in the United States. Mechanical reproduction of the classical music for the animated film; Conceptions of art music as a moral force for community uplift; Use of color, image, pattern and narrative to articulate musical experience for the audience. Cohen, Thomas E.: The Click Track. The Business of Time: Metronomes, Movie Scores and Mickey Mousing. In: Sound and Music in Film and Visual Media: An Overview. Ed. by Graeme Harper, Ruth Doughty & Jochen Eisentraut. London/New York: Continuum 2009, S. 100–113. Comerford, Lucy / Comerford, Peter J.: Dan and the Magic Musician: An Initiative by the Royal College of Organists Which Involves Us All. In: Organists' Review 94,4, Nov. 2008, S. 34–37. Dan and the Magic Musician is a CGI animated short film about a boy being introduced to the organ. The Royal College of Organists commissioned the film; the authors wrote the script, and it was animated by Karl Abson, of the School of Informatics at the University of Bradford, as his masters' thesis project. It is hoped that the film will help teachers include the organ in school music curricula and inspire more young persons to choose to study the instrument. An accompanying website, www.danmagic.org, provides additional information about organs as well as resources for teachers and parents to find each other, and publicizes organ-related events in the U.K. Comuzio, Ermanno: Eventi musicali. In: Cineforum 39,381, gen./feb. 1999, S. 11–13. On the importance of music for the 1990s animated film. – La colonna sonora dei film: Il principe d'Egitto (musica di Hans Zimmer e canzoni di Stephen Schwartz); Mulan (musica di Jerry Goldsmith e canzoni di Matthew Wilder); La gabbianella e il gatto (musica di David Rhodes. Riferimenti alle colonne sonore di Alan Menken (con testi di Ashman e Tim Rice). Conrich, Ian / Tincknell, Estella (eds.): Film's Musical Moments. Edinburgh: Edinburgh University Press 2006, xiii, 226 S. (Music and the Moving Image.). Darin: 1. Jazz, Ideology and the Animated Cartoon. Cook, Malcolm: Visual Music in Film, 1921–1924: Richter, Eggeling, Ruttman. In: Music and Modernism, c. 1849–1950. Ed. by Charlotte de Mille. Newcastle upon Tyne: Cambridge Scholars 2011, S. 206–228. During the early 1920s Hans Richter, Viking Eggeling, and Walther Ruttman produced a series of abstract animated films whose focus on qualities such as movement, rhythm, tempo, mood, counterpoint, harmony and composition was more akin to the concerns of music than the representational narratives that were characteristic of cinema in this period. All three of these artists were significantly influenced by music: Richter's interest in counterpoint was provoked by discussions with composer Ferruccio Busoni; Busoni also proved an influence on Eggeling who was a pianist and whose father owned a music shop; Walther Ruttmann was a cellist and violinist. The influence of music in their works can be understood in two very different ways; on the one hand the non-representational quality of music can be seen as an inspiration to explore the unique qualities of the artist's own medium, music serves as an analogy for the interrogation of the nonrepresentational qualities of painting or film. Cook, Malcolm: The Lightning Cartoon: Animation from Music Hall to Cinema. In: Early Popular Visual Culture 11,3, Aug. 2013, S. 237–254. Discusses, among others, the work of J. Stuart Blackton and Winsor McCay in the USA, George Méliès in France, and Walter Booth in the UK. Cook, Malcolm: Performance Times: The Lightning Cartoon and the Emergence of Animation. In: Performing New Media, 1890–1915. Ed. by Kaveh AsMusik im Animationsfilm // Medienwissenschaft, 164, 2016 /// 15 kari, Scott Curtis, Frank Gray, Louis Pelletier, Tami Williams & Joshua Yumibe. New Barnet, Herts: John Libbey Publishing / Bloomington, IN: Distributed in Asia and North America by Indiana University Press 2015, S. 48–56. The lightning cartoon act is an important example of a music hall performance which transferred into early moving images. It played a critical role in the formation of what would become known as animation not only in Britain, the primary focus of this chapter, but also worldwide. Key figures in the early history of animation are known to have performed this act, including J. Stuart Blackton and Winsor McCay in the United States, George Méliès in France and Walter Booth in the United Kingdom. This centrality of performance to animation has been highlighted in recent work by Donald Crafton [...]. Cooke, Mervyn: A History of Film Music. Cambridge/New York: Cambridge University Press 2008, xxi, 562 S. A comprehensive introduction to the major trends in film scoring from the silent era to the present, focusing on dominant Hollywood practices and offering an international perspective by including case studies of the national cinemas of the UK, France, India, Italy, Japan, and the early Soviet Union. The book balances wide-ranging overviews of film genres, modes of production and critical reception with detailed non-technical descriptions of the interaction between image track and soundtrack in representative individual films. In addition to the central focus on narrative cinema, separate sections are also devoted to music in documentary and animated films, film musicals and the uses of popular and classical music in the cinema. The author analyses the varying technological and aesthetic issues that have shaped the history of film music, and concludes with an account of the modern film composer's working practices. Rez. (Binns, Alexander) in: Music & Letters 91, 1, Def. 2008, S. 135. Rez. (Rogers, Holly) in: Twentieth-Century Music 7,2, Sept. 2008, S. 245. Rez. (Timm, Larry M.) in: Journal of the Society for American Music 8,3, Aug. 2014, S. 401. Rez. (Thompson, Brian C.) in: Fontes artis musicae 56,4, Oct.–Dec. 2009, S. 428. Corbett, John: A Very Visual Kind of Music: The Cartoon Soundtrack Beyond the Screen. In: The Cartoon Music Book. Ed. by Daniel Goldmark & Yuval Taylor. Chicago, IL: A Cappella Books 2002, S. 279–288. Examines aesthetic and existential aspects related to animation. Corradini, Bruno Ginnani: Chromatic Music. In: Animation Journal 4,2, [Spring] 1996, S. 78–84. Reprint of an text by the Italian futurist from the year 1912. Coyle, Rebecca: Hearing Screen Animation. In: Metro 161, Jun. 2009, S. 158–162. On the sound for animated film in Australia. Coyle, Rebecca (ed.): Drawn to Sound: Animation Film Music and Sonicity. London: Equinox / Oakville, CT: DBBC 2010, x, 258 S. (Genre, Music and Sound.). Animation films are widely consumed in the general population and the study of animation films has blossomed. But music and sound are often marginalized, despite the significance of soundtracks (music, voice talent and sound effects) for both the f


In prostate cancer, mutation of the p53 tumor suppressor gene has been associated with locally advanced disease and hormone-resistant disease that is predominantly localized to bone. However, little is known regarding the status of the p53 gene in metastatic prostate cancer that has not been treated with hormonab manipulation. We evaluated formabin-fixed, paraffin-embedded malignant tissues from 86 patients with various stages of prostate cancer, including pathologically confined, locally advanced, and metastatic disease, to detect abnormal p53 nuclear protein accumulation using immunohistochemistry. No abnormal p53 immunostaimng was detected in 18 patients with prostate cancer confined to the gland. Two tumors from 21 patients with locally advanced disease (extracapsubar extension and/or seminal vesicbe invasion) had abnormal nuclear p53 accumulation, and a mutation in exon 7 of the p53 gene was detected in tumor DNA from one patient using single-strand conformation polymorphism-direct sequencing analysis. Of the remaining 47 patients studied in whom tissues from the prostate gland and a metastatic site (44 lymph node, 2 bone, and 1 lung) were available, only 3 had received hormonal therapy prior to obtaining metastatic tissue. In four patients both primary and metastatic tumors demonstrated accumulation of p53 protein, whereas seven additional patients exhibited p53 accumulation only at the metastatic site. In three patients the metastatic tumors harbored missense single-base substitutions in exon 5, as detected using singlestrand conformation polymorphism-direct sequencing. These results indicate that p53 abnormalities are associated with lymph node metastases derived from prostate cancer patients that had not undergone hormonal therapy. INTRODUCTION The tumor suppressor gene p53 is centrally involved in inhibiting progression of the cell cycle at the G1-t'S-phase interface, giving the cell time to repair DNA damage before dividing, thus preventing replication of mutated DNA (1-3). This activity is accomplished in part via the transcriptional activation of p21, a cyclin-dependent kinase inhibitor (4-6). Mutations in the p53 gene could therefore permit DNA damage present in G1 to be carried into the S-phase, resulting in geneticalby unstable cells more prone to the development of a malignant phenotype (3, 4, 7). A number of human cancers including colon, lung, and breast have been shown to have p53 mutations (8-10). The wild-type p53 protein is undetectable using immunohistochemistry because of its short half-life. However, certain mutant p53 proteins have a longer half-life, resulting in nuclear accumulation. The finding of nuclear staining with anti-p53 antibodies is strongly suggestive of mutations within the p.53 gene (11). Several investigators have suggested a robe for p53 gene mutation in prostate cancer. Isaacs et a!. (12) evaluated five prostate cancer cell lines and two specimens of primary human prostate cancer for p.53 mutations by sequence analysis of exons 5-8. Three cell lines, all derived from metastatic sites, and one of the two clinical specimens demonstrated p.53 mutations and transfection of these cell lines with a wild-type p53 gene markedly reduced cobony formation. These studies suggested that the p53 gene plays a significant role in the development and/or progression of prostate cancer. Effert et a!. (13) analyzed 10 primary and 2 metastatic human prostate carcinomas using SSCP3 and direct sequencing of PCR products. p53 mutations were detected in 1 of 10 primary prostate cancers and I of 2 metastatic tumors. Bookstein et al. (14) analyzed archival tumor material from 150 prostate cancer patients using immunohistochemistry with anti-p53 antibodies. Abnormal nuclear p53 accumulation was detected in 19 tumors and was strongly correbated with higher stage disease. Recently, Navone et a!. (15) reported a relatively high frequency of p53 mutations in advanced hormone-refractory prostate cancer that was predominantly localized to bone. These authors concluded that p.53 mutations were associated, in general, with progression of disease, and specifically with hormone-independent prostate cancer. An immunohistochemical evaluation of 137 primary untreated prostate cancers from Finland found an association between high bevels of p53 accumulation and high-grade proliferating cell nuclear antigen-reactive, aneuploid tumors (16). Although only 6% of the tumors had high p53 accumulation, this subset had poor progression-free survival. A study by Chi et al. (17) reported a relatively high frequency ofp53 mutations in Received 1/5/95; revised 5/15/95; accepted 6/2/95. 1 Supported in part by the National Kidney Foundation Fellowship Award and Specialized Program in Research Excellence in Prostate Cancer Grant P50-CA58204 from the National Cancer Institute. 2 To whom requests for reprints should be addressed, at Scott Department of Urology, 6560 Fannin Street, Suite 1035, Houston, TX 77030. 3 The abbreviations used are: SSCP, single-strand conformation polymorphism; dNTP, deoxynucleotide triphosphate; H & E, hematoxylin and eosin; TURP, transurethral resection of the prostate. on May 1, 2017. © 1995 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from 1112 p53 and Prostate Cancer Metastasis prostate cancer. Overall, the frequency of p53 gene abnormabities in all prostate cancer specimens examined was 42%. In the present study, we further assessed the status of the p53 gene in human prostate cancer. Specifically, 86 patients with prostate cancer, for whom complete clinical and pathobogical information was available, were evaluated for p53 mutations using immunohistochemistry. This group included 47 patients for whom both primary and metastatic tissue samples were available. Prior to surgery, this subset of patients was considered to have clinically localized disease. To verify and further characterize mutations, all sections demonstrating nuclear accumulation of the p53 protein were analyzed by PCR amplification of DNA isolated from microdissected, formalinfixed, paraffin-embedded sections followed by SSCP analysis of exons 5, 7, and 8 and direct sequencing of the PCR products. PATIENTS AND METHODS Patient Population/Tissue Samples. A total of 86 patients with adenocarcinoma of the prostate were evaluated. Medical records of the patients were reviewed to obtain age at the time of surgery, surgical methods used to obtain the sampie(s), and pathological features of the tumor. Histopathobogicab grading was performed by one author (T. M. W.) according to the method of Gleason (18). All patients were pathologically staged using the TNM classification (19). Archival formabin-fixed, paraffin-embedded tissue was obtamed from the pathology files of The Methodist Hospital or Veterans Affairs Medical Center (Houston, TX). Specimens were available from patients who underwent radical prostatectomy and pelvic lymph node dissection for carcinoma confined to the prostate gland (n 18) or with locally advanced disease (tl = 21). In addition, tissue from both the primary and metastatic sites was available from 40 patients who had either radical prostatectomy (n = 22) or TURP (n 18). An additional seven patients had needle biopsies of the prostate available as well as pelvic lymph nodes. Serial 5-jim-thick sections were cut from each tissue block. One section was stained with hematoxybin and eosin, and an adjacent section was used for immunohistochemistry. Additional serial sections were used for microdissection to isolate DNA for PCR-SSCP and sequencing, which were foblowed by another section stained with hematoxybin and eosin to confirm the pathological features of the microdissected tissue. Immunohistochemistry. Nuclear accumulation of the p53 protein was demonstrated by the use of the mAb D07 (DAKO, Carpinteria, CA) and the polyclonal antibody CM-i (kindly provided by Dr. David P. Lane, Dundee, Scotland, United Kingdom), which have been shown to recognize p53 in formalin-fixed, paraffin-embedded tissue specimens (20). Seetions of a colon carcinoma, with a known p53 gene mutation, were used as a positive control with each experiment. Pelvic lymph nodes without histological evidence of tumor were used as a negative control. Sections (5 jim) from formalin-fixed, paraffin-embedded specimens were immersed in xybene to remove paraffin and then rehydrated in graded ethanol. Specimens to be stained with DO-7 were next immersed in S mM citrate buffer (pH 6.0) and boiled in a microwave oven for a total of 10 mm (21). Endogenous peroxidase activity was blocked with a solution of 0.3% hydrogen peroxide in methanol for 30 mm, after which sections were washed in PBS. Normal horse serum (3%) or normal goat serum (3%) was applied to the sections for 20 mm to bind nonspecific antigens. Incubation with a primary antibody (DO-7 at 1:50 or CM-i at 1:1500) was for 90 mm at room temperature. Sections were washed in PBS. Corresponding to each primary antibody, biotin-conjugated antimouse or antirabbit IgG diluted (1:200) in PBS (Vector Laboratories, Burbingame, CA) was applied for 30 mm, after which the sections were incubated with avidin-biotin complex (Vectastain ABC kit; Vector Laboratories) for 30 mm at room temperature. After additional washing, sections were developed for 4 to 7 mm using 3,3'-diaminobenzidine in PBS and 0.03% hydrogen peroxide. Slides were counterstained with 3% aqueous methyl green, dehydrated in alcohol, cleared in xylene, and permanently mounted. The accumulation of nuclear p53 protein was assessed by light microscopy using the following criteria: (negative) if <5% of the tumor cell nuclei were p53 positive; + (positive) if 5-20% of the tumor cell nuclei were p53 positive; + + if >20-50% of the tumor cells were p53 positive; and + + + if >50% of the tumor cell nuclei were p53 positive. DNA Extraction. Areas of prostatic carcinoma in either primary or metastatic tissue, identified


Game workers and reports on the videogame industry frequently
 document cases of anxiety, depression, burnout and impostor syndrome. Mental health issues
 are exacerbated among independent developers and freelancers. The article draws on
 interviews with four London-based independent videogame developers who have been producing
 'deep games' about mental health. The article argues that conceiving, producing and
 releasing these videogames is understood by their makers as a strategy to establish new and
 'deeper' relations with consumers, participants and other developers. Developers seek
 relations with other game workers and players through the process of making, researching,
 testing, and showing their videogames. Their responses draw on biographical self-reflexivity
 and are articulated within a network sociality that conceives the individual developer as
 the agent of change. The development of videogames about mental health is interpreted by the
 participants as facilitating exchanges of autobiographical experiences that are otherwise
 regulated by the norms of professional networking. At the same time, these exchanges aim at
 the establishment of new forms of sociality and at a fairer and more inclusive videogame
 industry.


ABSTRACT As the world seeks to engage with Indigenous values to respond to environmental issues, Indigenous peoples seek to meet that need through genuinely equitable partnerships. In Aotearoa New Zealand, preliminary work towards Māori participation in its Antarctic and Southern Ocean activities has begun. We further that work here by analysing two successful international approaches to negotiating Indigenous participation in environmental research, policy, and governance. In doing so, this paper examines how Māori and other Indigenous peoples might continue to work towards equitable participation in Antarctica and the Southern Ocean. Given the complex nature of the Antarctic region, our analysis focusses on case studies in similarly complex multijurisdictional areas, in the Arctic, and across the Murray Darling Basin in Australia. Working towards equitable participation in each of these cases has been supported by the collectivisation of Indigenous voices, use and establishment of strong Indigenous organisational structures, consistent influence on environmental law and policy, articulation of Indigenous policy, and alignment of Indigenous knowledges and worldviews with the environmental objectives of the regions. These lessons provide high-level principles to support Māori and other Indigenous peoples as they seek to bring new paradigms and values to support improved management of Antarctica and the Southern Ocean.


In this paper, a high accuracy attitude tracking control is presented for a quadrotor unmanned aerial vehicle (UAV) under the model uncertainties and external unpredictable disturbances by using a robust feedback control method. First, the cascade attitude dynamics of a quadrotor UAV is derived with the lumped disturbances. Then, a backstepping adaptive modified robust integral of the sign of the error (RISE) control is designed to improve the robustness of the control system against the disturbances. For arriving high accuracy tracking under the disturbances, a prescribed performance control algorithm is employed in combination to hold the transient state performance where the convergence rate is faster than the prescribed value, and the maximum overshoot is less than the prescribed value. The stability analysis is carried out to prove that the presented controller could guarantee that the closed-loop system is asymptotically stable, and the tracking feedback errors can converge to an arbitrarily small value near zero. The superior performance of the proposed control method is illustrated in simulations against the nonlinear lumped disturbances, and the benefits of the proposed robust controller is corroborated by comparing with the existed controller.


The invention relates to a method for establishing a communication link for transmitting data between two devices (4, 6) with electromagnetic waves, wherein each unit (4, 6), an electrode (8, 10), wherein an electrode (8, 10) a first device (4, 6) and an electrode (8, 10) of a second device (4, 6) of a person to be touched (2) simultaneously, wherein between the two electrodes (8, 10) via a body (16) the person (2) to be exchanged signals with information for setting up the communication link and the two devices (4, 6) for transmitting the data over the communication link based on electromagnetic waves, are set up.


AbstrcatBy using Authorware 5.2 Bioengineering Instroduction CAI courseware has been developed based on seperating source materials and structure in the main outline.Buttons are used to select chapters and sections,and functions are used to call sound control,Email,.midi music and Internet.This courseware has new interface and many functions,and the development method deserves popularization.


In memory device that is contained in the digital application, there is a sequence of input buffer.The input buffer's function is to improve a digital signal and remove noise. The buffer circuit take these input signal with imperfections and convert them in to full digital logic levels by slicing the signals at correct levels which depends upon the switching point voltage. In this paper,using three topologies, that are NMOS, PMOS and Parallel input buffer. It would be present into design, simulation and analysis of all topologies input buffer. The result in this paper to determine the best of the three topologies to used. The delay time used to determine the best of topologies. Mentor graphic is tools which used in this paper to design and simulation. The technology used in this paper is 0.35 µm CMOS Technology. Analysis of comparison all of topologies used in this paper based on six parameters. The result of comparison analysis can be seen in more details in this explanation.


Comparative Evaluation of Salivary Nitric Oxide and Epidermal Growth Factor in Diabetes Mellitus Type 1,2 and Healthy Group , Comparative Evaluation of Salivary Nitric Oxide and Epidermal Growth Factor in Diabetes Mellitus Typ... , بانک اطلاعاتی جامع اطلاع رسانی پایان نامه های کشور


In this paper a spectral theory pertaining to Quasi-Birth‐Death Processes (QBDs) is presented. The QBD, which is a generalization of the birth‐death process, is a powerful tool that can be utilized in modeling many stochastic phenomena. Our theory is based on the application of a matrix polynomial method to obtain the steady-state probabilities in state-homogeneous finite-state QBDs. The method is based on finding the eigenvalue‐eigenvector pairs that solve a matrix polynomial equation. Since the computational eAort in the solution procedure is independent of the cardinality of the counting set, it has an immediate advantage over other solution procedures. We present and prove diAerent properties relating the quantities that arise in the solution procedure. By also compiling and formalizing the previously known properties, we present a formal unified theory on the spectral properties of QBDs, which furnishes a formal framework to embody much of the previous work. This framework carries the prospect of furthering our understanding of the behavior the modeled systems manifest. " 2001 Elsevier Science B.V. All rights reserved.


Simple Summary With old age, the strength and size of our muscles worsens with time, affecting our ability to carry out daily activities. Muscle wasting may be more dangerous for some people, causing falls, inactivity, and a loss of self-sufficiency. This severe muscle-wasting condition is called sarcopenia. Mitochondria are sub-cellular organelles involved in the regulation of determinant functions in muscles, such as energy production and programmed cell death. The present review describes muscle modifications and mitochondria alterations occurring in old age, digesting the most important discoveries on mitochondrial changes in sarcopenia. Our comprehensive summary of scientific advances in this field during the last years will be of help for researchers to design future investigations which clarify further aspects of mitochondrial involvement in sarcopenia and define the impact of mitochondria-targeted therapies for the prevention and treatment of sarcopenia. Abstract Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis. During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting in loss of muscle mass and function. Thus, mitochondrial dysfunction contributes significantly to the complex pathogenesis of sarcopenia, and mitochondria are indicated as potential targets to prevent and treat this age-related condition. After a concise presentation of the age-related modifications in skeletal muscle quality and mitochondrial homeostasis, the present review summarizes the most relevant findings related to mitochondrial alterations in sarcopenia.


The selective syntheses of the cyclic monoterpenoids α-terpineol or α-cyclogeraniol from the acyclic monoterpenoid nerol using p-toluenesulfonic acid or chlorosulfonic acid as cyclizing agents, respectively, are described. The different behavior of nerol under diverse experimental conditions such as nature of the acid agents, solvents, and reaction temperatures is analyzed. The didactic usefulness of these experiments has been rationalized.


The evaluation results of power system are greatly influenced by the reliability parameters and uncertainty of system components. The connection number assessment model and an approach have been presented to assess the occurrence frequency due to voltage sags. The proposed method had been applied to a real distribution system. Compared with the interval number method, the simulation results have shown that this method is simple and flexible.


Progress has been made in developing statistical methods for identifying DIF items, but procedures to aid with the substantive interpretations of these items have lagged behind. To overcome this problem, Roussos and Stout (1996) proposed a multidimensionality-based DIF analysis paradigm. We illustrate and evaluate an application of this framework as it applied to the study of gender differences in mathematics. Four characteristics distinguish this study from previous research: the substantive analysis was guided by past research on the content and cognitive-related sources of gender differences in mathematics achievement, as presented in the taxonomy by Gallagher, De Lisi, Holst, McGillicuddy-De Lisi, Morely, and Cahalan (2000); the substantive analysis was conducted by reviewers who were highly knowledgeable about the cognitive strategies students use to solve math problems; three statistical methods were used to test hypotheses about gender differences, including SIBTEST, DIMTEST, and multiple linear regression; and the data were from a curriculum-based achievement test developed with the goal of minimizing obvious, content-related gender differences. We show that the framework can lead to clearly interpretable results and we highlight both the strengths and weaknesses of applying the Roussos and Stout framework to the study of group differences.


The story of the conflict of values and of the short-sighted compromise that resulted in the Social Security system as we know it today.


The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radioiodine. Also provided are novel radioiodinated BTMs prepared using the method, as well as radiopharmaceutical compositions comprising such radioiodinated BTMs. The invention also provides radioiodinated intermediates useful in the method, as well as in vivo imaging methods using the radioiodinated BTMs.


In №422 fully mechanized caving mining face of Chenjiashan coal mine,the strong periodic pressure leads support subsidence and lack of walkway height and then safety production is effected.By using the data of KJ216 roof dynamic monitoring system,the paper analyzed the relationship of support's setting load with working resistance and roof subsidence,pointed out the important of the balance of support system,proposed the selection method of reasonable support resistance and achieved safety production.


A high performance, 128×128 pixel, snapshot Readout Integrated Circuit (ROIC) for IRFPA has been fabricated with 0.5μm Double Poly Double Metal (DPDM) n-well CMOS process. The pixel cell circuit uses an improved direct injection structure with only four transistors to maintain large enough integration capacitror. One pixel cell occupies an area of 50×50μm2. Each row's pixel signals are readout to the column amplifiers row by row in parallel, while the column amplifiers are reset after each row's pixel signals are readout. The whole pixel cells are reset wholly after a frame signals are all readout. The ROIC structure also provides dynamic image transpositionxinyuanjing xinyuanjing xi (Invert, Revert) function to support a wide range of system requirements. It still has a build-in temperature sensor to detect the temperature of the chip. The measurement results show that the readout chip works well at both room temperature and 77K with 5V supply voltage. The fabricated chip has a maximum charge storage capacity of 6.48×107 electrons and the active power dissipation of about 10mW. The proposed CMOS ROIC structure has been applied to IRFPAs.


The invention discloses a treatment method for organic industrial wastewater. The method comprises the following steps: the pH of wastewater is regulated in a regulation pond; the wastewater enters an iron and carbon reaction tank to be treated, carries out Fenton reaction treatment, and then enters a neutralization sedimentation tank to be precipitated; yielding water enters an aerobic granular sludge aeration tank to be treated and then stays for a period of time, and then water is flowed out. The method can reach the treatment requirements and protect the environment, and the wastewater can be reused after treatment. The method has the obvious characteristics of cost and water resource saving, stable and reliable treatment effect, simple and easy operation, lower running cost, easy industrial application, etc.


A large number of amino acids failed to support growth of Pseudomonas denitrificans in a basal medium composed of glucose, ammonium phosphate, and other mineral salts. Inability of an amino acid to support growth correlated well with its inhibitory action in a complete medium made up by adding L-glutamic acid to the basal medium. D-Amino acids were more toxic than the corresponding L-forms, and neutral amino acids were more toxic than acidic amino acids. Basic amino acids which were least toxic supported the best growth. The danger of the indiscriminate use of amino acid mixtures for culture studies is discussed.


The present invention has an audio highlight part recording / reproducing method and apparatus and a recording medium on which additional information is stored for this purpose is disclosed. A specific part of the present invention is specified audio track a specific portion of the audio track, the user, when recording / reproducing the audio data desired from / on the recording medium is recorded with a plurality of audio tracks by specifying, and represents part as a representative part of the track even if the types of the audio tracks on the recording medium by recording the reproduction information on a predetermined region on the recording medium for reproducing the user the corresponding track can be easily determined in a short period of time whether any songs.


A novel flue gas desulfurization process, which applies a mixture of caprolactam tetrabutyl ammonium bromide ionic liquid ([CPL][TBAB] IL) and sodium humate (HA–Na) solution, was proposed. This study relates to the SO2 absorption efficiency and products of removing SO2 in a bubbling reactor, especially the effect of recycling the mixed aqueous solution. The experimental results indicate that the maximum absorption efficiency of SO2 approaches almost 95%, thereby allowing this mixed solution to be used repeatedly up to 5 cycles. However, the initial pH of the mixed aqueous solution, which was prepared by recycling the mixed solution, dropped from 10 to 7.5 while the cycle number increased from 1 to 5. Meanwhile the final pH of the mixed aqueous solution remains almost a constant (2.1) after the completed absorption reaction. The desulfurization time and the absorption amount of SO2 decreased as the cycle number rises. The FT-IR spectroscopic and XPS results of desulfurization product show that humic acid (HA) can be sulfonated to some extent in this process. This finding provides a testimony that HA can react with sodium bisulfite in a Michael addition reaction, and [CPL][TBAB] IL can play a role in this reaction as a catalyst. The chief by-product is compound fertilizer consisting of sulfonated HA and sulfates.


The end panels of a large rectangular industrial duct experience significant internal pressures and considerable transverse shear at the support locations. Though the designers depend on the plate girder design methods, the structural dimensions and the arrangements, the loadings and the resulting behaviour of the such end panels are significantly different. Large aspect ratio of the end panels gives rise to multiple bands of tension fields and significant membrane action, whereas the plate girder web design is based on one tension field. In this investigation, a nonlinear finite element model was developed to simulate the behaviour of industrial duct end panel subjected to transverse shear and internal pressures. The model considered the geometric imperfections and constitutive relations for steels. Six scale independent dimensionless parameters that govern the behavior of such end panels were identified as ⁄ √ ⁄ ⁄ ⁄ ⁄ and ⁄ , which were then used in an extensive parametric study, which primarily established the ultimate shear strength of end panels. It was concluded that the plate slenderness dominates the shear strength of stockier end panels, whereas, the aspect ratio and plate slenderness influence the shear strength of slender end panels. This paper proposes design aids for shear strength of thin end panels subjected to concurrent transverse shear and internal pressures.


The SSTH-70 "Ocean Arrow" designed under the concept of the SSTH (Super Slender Twin Hull), which IHI developed with the University of Tokyo, has been in operation for about three years. The speed of SSTH-70 is almost twice compared with the conventional ship. During the half year after delivery, the ship motion and wave impact load for the hull structure were measured. This paper describes the design method of hull structure for SSTH as a fast ferry and the full scale measurement on an actual ship to evaluate the estimated ship motion and wave loads. This paper also introduces the future design of the 110m length SSTH Car Ferry based on the results of full scale measurement which will have good sea-keeping performance and feature less wake wash.


Most cultivars of C. olitorius (tossa jute) suffer extremely during early growth phase either due to lean season or insufficient rainfall to maintain steady growth. Tolerant genotypes may overcome this problem maintaining sustainable growth at early growth. Sixty genotypes of C. olitorius were evaluated for identification of moisture stress tolerant genotypes using PEG, in field and pot under rainfed condition. The characters considered were root length, root volume, shoot length, root fresh weight, shoot fresh weight, leaf fresh weight, root dry weight, shoot dry weight, leaf dry weight, and tolerance index which showed significant differences among genotypes under different water regimes for stress tolerance. On the basis of seedling characters OEX 29 was found to be consistent by highly tolerant to moisture stress after evaluation in laboratory, field and pot culture. Genotypes OIJ 177 and OIN 791 showed tolerance, whereas, JRO 524 followed by JRO 632, JRO3690, JRO 8432, OIJ214 and OIN 970 were found to be the most susceptible genotypes.


The use of web-based surveys has expanded rapidly during the past few years as the number of Internet users increased. However, lack of representativeness cause hesitation in utilizing data collected via the internet as compared to more conventional sampling methodology. This paper analyses the problem of non-representativeness in open online surveys using a passive sampling method, taking as an example the results of the ANU Internet Opinion Poll (ANU Poll) conducted in research on the 2004 Australian federal election. It clarifies that the sampling bias in online polls causes inaccurate statistical inferences.


Based on the current status of undergraduate education of automatic control theory and aiming at enhancing engineering awareness and cultivating engineering ability,some innovation plans and some particular implementation methods are put forward at reforming experiment teaching,developing extracurricular activities of technology innovative,building course website,perfecting cognition practice.Reform practice proved that students' study interest and innovative and engineering ability are greatly enhanced.


Landslide dams (i.e., the natural blockage of river channels by hillslope-derived mass movements, COSTA & SCHUSTER, 1988) are natural phenomena with great relevance on geomorphological conditions and on the safety of people. Landslide dams can induce significant geomorphic hazards in the adjacent areas. Flooding by impounded water can create large lakes in the upstream areas, causing damages to human activities. Catastrophic outburst floods and/or debris flows can be triggered by a rapid dam failure with exceptional rates of sediment erosion and deposition along the downstream part of the valley. The damming of the valley bottom can occur with different modalities (COSTA & SCHUSTER, 1988) as a function of: the landslide type (e.g. rock avalanche, debris avalanche, debris flow, rock fall, rockslide, rotational failure, rock-block slide, deep-seated complex failure, earthflow), its size and geometry, the forming material, the velocity, the size and conditions of the valley bottom, the geomorphological conditions at the landslide dam site and of the catchment upstream of the dam, the river discharge. Fast moving and long run out landslides are among the main causes of damming because the large amount of material, rapidly transported and piled up at the valley bottom, can be eroded only through very large water discharge. Occurrence of the erosion and down-cutting of the accumulation is more difficult because of armouring by the presence of a carapace of large to very large blocks. Geometry of the valley can control the shape of the accumulation with consequences on its stability. The internal part of the accumulation is often described or assumed as homogeneous but its properties must be related to the complex motion and set of mechanisms occurring during the put in place. Translation, sliding and internal deformation or shear participate in the motion and deposition of rock avalanches as well as other granular flows. Translation or sliding imply the resisting action at the base of the flowing material along the infinitesimal thickness of the sliding surface. The internal deformation and the interaction with a rough basal topographic surface imply the resisting action of the flowing material along its entire thickness under variable stresses. Entrainment or deposition of the material can induce important changes in momentum, volume, material properties, and runout distance. This complexity is at the origin of many different theories proposed to explain the exceptional mobility of rock and debris avalanches. We present and discuss data from the 1987 Val Pola rock avalanche. Field surveys, in situ and laboratory tests are presented and discussed as means to perform modeling of the landslide movement and of the evolution of the accumulation.


All steel sandwich panels are at present under extensive research and new applications are studied. Helsinki University of Technlogy (HUT)/Ship Laboratory and Laserplus have conducted co-operative research to develop design methods and production technology for these type of structures since 1994. The topics studied include e.g. ultimate strength analysis, joint design and fatigue strength analysis, fire and noise testing. A special computer program is developed to optimise the design solutions for sandwich panels with various core structure configurations. The program developed is briefly summarised in this paper and few case studies are conducted to compare the weight optimised design solutions. Finally the production methods and possible problem areas applying laser welding for these panels are discussed.All steel sandwich panels are at present under extensive research and new applications are studied. Helsinki University of Technlogy (HUT)/Ship Laboratory and Laserplus have conducted co-operative research to develop design methods and production technology for these type of structures since 1994. The topics studied include e.g. ultimate strength analysis, joint design and fatigue strength analysis, fire and noise testing. A special computer program is developed to optimise the design solutions for sandwich panels with various core structure configurations. The program developed is briefly summarised in this paper and few case studies are conducted to compare the weight optimised design solutions. Finally the production methods and possible problem areas applying laser welding for these panels are discussed.


To compare maternal and neonatal outcomes between the 'head first' and 'legs first' delivery methods during a second stage cesarean section.


Kalmegh [Andrographis paniculata (Burm. f.) Wall. Ex. Nees] belonging to the family acanthaceae is one of the most important medicinal crops, indigenous to India and Sri Lanka. The fresh and dried leaves and juice extracted from the herb are official drugs in Indian pharmacopoeia and have been used in Indian systems of medicine since time immemorial. Looking at the utility and pharmacological importance of Andrographis paniculata, an overview is conducted considering some useful aspects like, origin and distribution, plant botany, taxonomy, genetics, edaphic and climatic requirements, methods of propagation, important varieties, planting geometry, nutrient management, irrigation management, insectpest, diseases and weed management, maturity and harvesting period, therapeutic uses, phyto-chemistry and phamacognosical studies to initiate systematic and commercial cultivation of kalmegh for industrial uses.


DLR's Modular Optoelectronic Scanner MOS on the Indian Remote Sensing Satellite IRS-P3 has been working now for almost 5 years in orbit. In September 2000 the power supply for driving the internal lamps and the sun calibration equipment failed so that we no longer have actual in-orbit calculation values. However the spectrometers themselves are still working and nadir remote data collection is running. To remedy this situation we have tried to use vicarious calibrations over the Sahara desert. The Great Eastern Erg near the border between Tunisia and Algeria has been selected for this purpose. Because we do not have any ground truth measurements from this area, we have investigated the correlation between the in-orbit sun and internal lamp calibration data and the upwelling radiance data of this area in the VIS/NIR-channels of MOS from May 1996 to August 2000. The vicarious calibration data were corrected with respect to actual sun irradiance only, but not to atmospheric conditions. Nevertheless there is a remarkably high correlation between the in-orbit calculations and these vicarious calculations. This enables us to continue to generate calibration data sets for MOS only by using actual vicarious calibration data in place of the in-orbit calibration data. Additionally the vicarious calibrations can be compared with the extrapolated results of the time trend of the radiometric sensitivity of all spectral channels which we found from the previous in-orbit calibrations. The results of all these investigations are presented in this paper.


In order to estimate the physical characteristics of the mechanical system and shorten the development cycle, this paper studies the principles and related technologies of the generation of physically-based animations, and combines the Bullet physics engine to simulate the dynamics of rigid bodies, and produce physically-based animations. The basic principle of physics animation is based on dynamic equations. The numerical solution technology is used to solve the dynamic equations. The actual motion of the rigid body will not penetrate, and collision detection is required. The Bullet physics engine is used to calculate the motion process of a rigid body, and OpenGL is used for rendering, and the two are combined to realize the simulation process.


Objective To compare the gene expression profile of cerebral cortical tissues removed surgically in patients with posttraumatic epilepsy with that in patients with non posttraumatic epilepsy for attempting to elucidate molecular pathogenesis and applicability to forensic appraisal on posttraumatic epilepsy.Methods 15 epileptic cerebral cortical tissues from patients with post-traumatic epilepsy cortex and 15 epileptic samples from those with non-traumatic epilepsy were collected.Each sample's RNA was extracted.The RNA was hybridized to the human microarrays expression gene chip.Microarray images were scanned.The signal intensities and ratios were analyzed.Then the differential expression genes were obtained by clustering analysis with GENE WORK software designed by IBM.Results Expression level of over 2 990 genes exceeded the background by at least 2-5 folds in both the samples and these genes were included in the analysis.Using expression regulating level higher than 1.5 fold in over 30% of the samples as the criteria of discriminating gene,a total of 192 genes displayed significantly differential expression in posttraumatic epileptic samples as compared with those in non-posttraumatic epileptic samples,among which 115 genes were up-regulated and 77 genes down-regulated.Conclusions Gene microarray technique can be used effectively for discriminating differentially expressed genes in posttraumatic epileptic cerebral tissue from those in non-posttraumatic epileptic samples and is helpful for investigation on pathogenesis and molecular subtyping of posttraumatic epilepsy.


[Objective]To observe the ZhiXiao save lung soup joint budesonide aerosol treatment of asthma clinical efficacy.[Methods]82 patients with asthma were randomly divided into treatment group and control group of 41 cases.The two groups were given budesonide suspension atomization inhalation,every 20 minutes,3 times a day.On this basis,the treatment group plus ZhiXiao save pulmonary soup,a daily,decoction hours service.The two groups were treated for 7 days for a course.[Results]The total efficiency of the treatment group was 85.37% in the control group was 58.54%,the difference was statistically significant(P0.05).Treatment group,asthma,pulmonary moist rales and wheezing,coughing and other symptoms disappeared a short time in the control group(P0.05).Two sets of index of pulmonary function after treatment for 14 days,the difference was significant(P0.05)[.Conclusion]The the observed ZhiXiao save lung soup budesonide aerosol treatment of asthma.


The present article aims to put forward the advances of the research about the coastal-maritime territorialities in one locality of the East Uruguayan coast. In this thesis my purpose, following Latour's (2005) studies, is to follow the associations between different "actants" in the coast region and the relations with that place, as well as analyze the possible constructions assembled by them. I want to study how the maritime-coastal space has been built and in the process of inhabiting it. (INGOLD, 2002). For this propose, I get back to Ingold's perspective in dialogue with Latour (and other theories),


The 6LoWPAN WG defined a network interface and its protocol to communicate via IPv6 packets is designed for the 802.15.4 PHY/MAC. 6LoWPAN assigns each 802.15.4 device with an IPv6 address, and it defines a new adaptation layer for 6LoWPAN because 802.15.4 frame packets are much smaller than the MTU size. This adaptation layer compresses, fragments, and reassembles IPv6 packets and headers to form an 802.15.4 frame [?]. Not onyl for IEEE 802.15.4, more recently, the IETF 6lo working group (IPv6 over Network of Resource-constrained Nodes) has been organized to distribute similar compressed IPv6 technology across many communication mediums, such as Bluetooth Low Energy (BLE) and NFC. In this paper, we tackle to alleviate this inefficiency for 6Lo-connected networks by providing a data aggregation scheme for non-real-time requiring traffic. Our results show that the packet overhead reduces by as much as 43% using our improvements.


A memory alloy embracing type artificial hip joint prosthesis comprises an embracing handle body, wherein multiple pairs of embracing arms are symmetrically arranged on the embracing handle body, a fixation hook in the same direction with the embracing arms is arranged at the lower end of the embracing handle body, a handle body slope is arranged at the upper end of the embracing handle body and located on the opening sides of the embracing arms, a solid head-neck part is arranged on the handle body slope, and a slip catch is arranged at the lower end of the handle body slope. Before the prosthesis is implanted, the prosthesis is placed into disinfectant brine ice, the embracing arms are dilated by medical dilating forceps, the handle body slope and an affected bone removal surface coincide during implantation, holes are bored in positions, corresponding to the slip catch and the fixation hook, of a femur, the slip catch and the fixation hook are inserted into the corresponding holes for fixation, then the hot compressing is performed on the embracing arms with gauze soaked with disinfectant brine until the embracing arms recover the original shapes completely, and the implantation is finished. The memory alloy embracing type artificial hip joint prosthesis adopts a special memory effect of a nickel-titanium memory alloy material, the memory alloy has few foreign body reactions, the postoperative complications are reduced, and safety, simplicity and convenience are realized in a mounting process.


The results of oxidation of some mono-aryl aliphatic olefins by chromic acid in aqueous sulphuric acid and by chromic oxide in acetic anhydride are compared and discussed.


) can be potential resources for HIV-related stigma reduction, the paper shares the experience of Sudanese People living With HIV/AIDS Care Association (SPCA) on reducing self-sigma among the PLHIV themselves and on the other hand reducing


An experimental study was carried out at infertility clinics. This study aims to assess the couples' knowledge regarding infertility and their level of anxiety. Purposive sample of 200 couple have been chosen while they were visiting the clinic. A structured questionnaire was constructed for the purpose of assessing the knowledge regarding infertility and Hamilton Anxiety Rating Scale was used to measure the level of anxiety among them. Data were collected before and after video assisted teaching programme. Descriptive and inferential statistics were used to analyse the data. With respect to the level of knowledge majority 120 (60%) of them had inadequate knowledge, 80 (40%) of them had moderate knowledge on diagnosis of infertility whereas in post test 160 (80%) of them had adequate knowledge, 40 (20%) of them had moderate knowledge and none of them showed inadequate knowledge in post test. The mean and standard deviation of pretest knowledge among couples (m= 20.03, S.D= 3.28) were lesser than that of posttest knowledge (m= 32.9, S.D = 2.80) and thus indicates the effectiveness of Video assisted teaching programme. With respect to the level of anxiety majority146 (73%) of them had severe anxiety, 54 (27%) of them had moderate anxiety whereas in post test 134 (67%) of them had mild anxiety, 166(33%) had moderate anxiety and none of them showed severe anxiety in post test. The mean and standard deviation of pretest level of anxiety among couples (m= 48.03, S.D=2.28) were higher than that of posttest level of anxiety (m= 20.9, S.D = 1.80) and thus indicates the effectiveness of Video assisted teaching programme. Thus the study findings accepted the research hypothesis that there is significant difference in the level of knowledge and anxiety following the video assisted teaching programme among infertile couple. There is statistically significant negative relationship between the pretest level of knowledge of the infertile couples and pre test anxiety level (*P<0.004), between the post test level of knowledge of the infertile couples and the pretest level of anxiety (**P<0.01). There was no statistical association between the couple's knowledge on infertility and selected common demographic variables in pretest at p < 0.05. There was no association between the couple's anxiety level and the selected demographic variables in post test at p < 0.05. From this study, the researcher found that the couples have gained knowledge regarding infertility and perceived less anxiety due to the video assisted teaching programme. Hence the nurse midwife suggests that formulated teaching not only helps to gain knowledge on the particular area and it also helps them psychologically to develop positive attitudes towards fertility by decreasing their anxiety and to maintain the healthier relationship with the society.


The present work observation begins about prejudice/ reality existing about Spanish classes, as a discipline irrelevant, boring and useless, the students' views, and they do not learn effectively in school. The problems that guide this Project is as, and which the contributions the digital Technologies can bring, in changing this vision. The methodology used will be, analysis of questionnaire on knowledge and initial vision of students on the Spanish language and after exposure to different classes, with the use of various digital Technologies and the results of this practice. Justified the relevance of this work to bring contributions in preparing lessons, that will provide a more meaningful.


This research note explores conflict-handling styles from the Islamic perspective. According to Quran and the prophetic remarks, Islam prohibits dominating style and encourages obliging style, while it considers compromising, integrating and avoiding styles as acceptable for resolving interpersonal conflict. Managers can use the knowledge of Islamic instructions in their training, mentoring and counselling to handle conflicting parties within the organization and reduce the level of dysfunctional conflicts. In the end, the note offers indications for future studies where the level of religiosity (Islamic) may be a befitting mediating variable. Also, there may be studies on the influence of Islamic values in specific areas of human interactions within the workplace.


Abstract A new series of pyrimidine derivatives are reported here as antitumor agents such as pyrimidine carboxamide linked to thiophene, pyrazole, and thiazole moieties have been synthesized from the readily available (2-cyano-N-(5-cyano-2-phenyl-6-arylpyrimidin-4-yl)acetamide (6a,b). All the new compounds were screened for their antitumor activity in vitro against a panel of three human tumor cell lines namely, hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Compounds 9b, 10b, 11b, and 19b displayed a significant therapeutic activity. All the synthesized new compounds were established their structures by means of spectroscopic analysis. Graphical Abstract


INTRODUCTION: The COVID-19 pandemic has changed the educational experience of trainees in Gastroenterology (GI) training programs Understanding how these changes have affected GI training is important for ensuring clinical competency of our current trainees and for future curricula planning purposes METHODS: We sent an email invite to complete the anonymous online survey to all program directors (PD) of ACGME-accredited GI fellowship programs Surveys were completed between May 11th to June 5th, 2020 The study was approved by the institutional review board RESULTS: 44/205 (21%) PD completed the survey At the time of the survey, programs were operating within the following ACGME defined stages of GME training: 7 (15 9%) were at stage 1, "business as usual," 27 (61 4%) were at stage 2, "increased clinical demands," and 10 (22 7%) were at stage 3, "pandemic emergency status " Endoscopy Training: All PD reported decreased outpatient procedure volume for trainees with 70 5% reporting a greater than 75% decrease 93 2% of PD reported decreased inpatient procedure volume with 34 1% reporting a greater than 75% decrease (Figure 1) Inpatient Consults: All PD reported fellows continued to perform inpatient consultations, but 50% of PD reported changing the structure of the consult service 27 2% of PD reported a more than 50% decrease in the volume of consultations (Table 1) Outpatient Clinics: 90 9% of PD reported trainees continued outpatient clinics, but 81 9% of PD reported trainees saw fewer patients The form of patient interaction changed in most programs: 75% used telephone visits;55% used video visits;and only 30% maintained in-person visits (Table 1) Virtual Conferences: 81 8% of PD reported a high attendance rate (>80%) of virtual conferences Though, 27 3% of PD considered virtual conferences a worse experience, and 70 5% of PD reported difficulty with engaging fellows in virtual conferences (Table 2) Overall Feedback: 72 7% of PD were worried that the pandemic would significantly decrease endoscopy exposure of the fellows, and 59 1% of PD were worried about the decrease in outpatient clinical experiences CONCLUSION: The COVID-19 pandemic impact on US GI fellowship programs is significant, with large decreases in endoscopy and clinical encounter volume and shifting of clinical interaction away from in-person visits Virtual conferences are highly attended, but engagement is challenging Further adjustment of GI training programs is needed to accommodate these changes (Figure Presented)


This paper presents an experimental study of cooling effectiveness of the designed high-pressure fogging system in the World Expo axis. Eligible meteorological condition of air temperature is upon 30°C and its humidity is below 70% and different pressures of the pump were conducted in the experiment. The experimental results shows the high-pressure fogging system has a positive cool effect in the Expo axis, as a result of 2-3°C temperature descent and about 10% humidity ascend. Under fogging pressures of 7 MPa, 5 MPa, 3 MPa, the temperature descent is respectively 4.7°C, 3.6°C and 3.2°C, and relative humidity raise in 20.7%, 12.2% and 14.3%, furthermore, the black bulb temperature correspondingly drop 4.61°C, 4.1°C, 2.35°C at the distance of 1 m from the fogging pole.


Resolving systemically important financial companies without providing public assistance has been an elusive objective. Although popularly characterized as 'too big to fail', in reality these companies are systemically important due to being too connected or integrated into the financial system to fail without causing harm to the broader economy. During the 2008 financial crisis policy makers opted to provide public support to systemically important firms rather than allowing them to fail and further destabilize an already distressed financial system. To address the immediate need to minimize economic fall-out, governments increased moral hazard and the market distortions resulting from 'too connected to fail'…


I became a member of the Indian Psychiatric Society in 1969, the same year as I completed my post graduate training in psychiatry. A few months later I had the memorable experience of attending the society's annual conference and presenting a paper. Since then, IPS has always given me a sense of belonging, a sense of comraderie with fellow psychiatrists in every nook and corner of this country and opportunity'to share concepts and concerns with them. I have had the opportunity to take up many responsibilities in this organisation and to me each of those occasions was a milestone in the growth of my emotional attachment to the IPS. As I assume the office of the President of our society, I consider it as the beginning of yet another phase in this ever growing relationship and I thank my fellow members for making it possible.


We present a self-consistent analysis of the topological superconductivity arising from the interaction between self-ordered localized magnetic moments and electrons in one-dimensional conductors in contact with a superconductor. We show that due to a gain in entropy there exists a magnetically ordered yet non-topological phase at finite temperatures that is relevant for systems of magnetic adatom chains on a superconductor. Spin-orbit interaction is taken into account, and we show that it causes a modification of the magnetic order yet without affecting the topological properties.


Current practice for design of reinforced concrete bridges is based on a linear elastic structural analysis in which a suitable distribution of sectional forces is sought. In Sweden such an analysis is today required to account for the structural response in its entirety, implying a demand for three-dimensional (3D) models capable of describing the force distribution in longitudinal and transverse directions. To account for structural behaviour in a model there is an abundance of different modelling techniques which can be utilised. With modern user-friendly 3D finite element analysis software the amount of available modelling techniques becomes even more apparent. This thesis investigates different methods for 3D structural analysis of concrete bridges at a design stage. The aim is to illuminate differences and the impact different modelling procedures and choices made in the modelling process has on the resulting design of a bridge. Case studies have been performed where different modelling techniques was investigated. Different models have been established and the results from structural analyses compared. Resulting sectional forces and reinforcement design show only small differences between different modelling techniques. The results show that the choice of structural model for analysis at a design stage has little impact on the results. As long as a structural model doesn't introduce errors in the evaluation of the response, other parameters are more important than the accuracy in the model. Such parameters are for example user friendliness, verifiability and interpretation of results. The results also indicate that there is a lack of established procedures and guidelines for modelling and verification. Such guidelines would simplify the work for engineers when establishing structural analysis models and set the foundation for collaboration and common working procedures within the industry.


Research-intensive universities in the global peripheries have begun to mount English for research publication purposes (ERPP) initiatives to increase plurilingual scholars' publishing success. Though research into pedagogical initiatives is still limited, investigations of such programs can provide researchers with a greater understanding of the broader experiences and perspectives of scholars as well as the potential impact of interventions on course participants' scholarly writing. Answering the call for more longitudinal work in ERPP, this article outlines a small-scale, qualitative investigation of the perceived impact of an intensive ERPP course at a Mexican university on two environmental scientists' research writing five years following course completion. Data analysis included systematic review of participant CVs, as well as semi-structured interviews with two plurilingual EAL scientists and two ERPP practitioners connected to the ERPP course. Employing a critical plurilingual lens, this article discusses findings that not only outline the perceived impact of the intervention on these scientists' research writing at different stages of their academic trajectories, but also highlight the plurilingual nature of their evolving scholarly practices. The article culminates with data-driven suggestions for plurilingual conceptualization and enactment of scholarly writing pedagogies, policies, and research agendas.


Das Neue Recht der Schiedsgerichtsbarkeit (The New German Arbitration Law) edited by Klaus-Peter Berger. Published by RWS Publishers, Dokumentation 21 (1998, 800 pp ). Softback Price DM148. ISBN 3-8145-1876-4. In German and English .

Now it will be safe to arbitrate in Germany. Before the 1998 New German Arbitration Law, it was no accident that Europe's finest procedural lawyers were German. Both Germans and non-Germans needed them. Foreign lawyers comfortable with ad hoc arbitration in Paris, Geneva, Stockholm and London shied at German arbitration. There was something 'of the night' about it. And for a country rich in international arbitrators, it seemed odd that so much of their work was directed abroad. Now, at the dawn of the new millennium, a new era has begun for German arbitration; and once …


A movable vacuum filth discharging vehicle for passenger trains. It mainly settles the problem of environment protection and convenience. The vehicle includes a vehicle chassis, sucking system, electric control case. It is characterized in that the vehicle chassis is an electromotor chassis including storage batteries for vehicles and electric machinery. The sucking system covers a tin, the top of which is connected with the sucking slot. A blow-down valve is equipped at the bottom. The other end of the tin is connected with a filtered non-return can, which is connected with the vacuum pump of the DC motor. The electric control part, including a DC electric motor and storage batteries, is connected with the electric control case. The utility model is simple in structure and convenient to use with good reliability. It is of strong sucking function, reduction secondary pollution. The utility model required less regular maintenance. The service costs are also low. It is a small filth discharging vehicle used specifically for railways, which is suitable to collect the night soil in the decrement case and take them to a special place to discharge.


Commodity use value theory, an essential part in Marxist political theory, plays a guiding role in contemporary economic life. A deep understanding and thorough study of Marxist theory of commodity use value will ensure the scientificity in economic life and the enrichment and development of this theory in the socialist economic construction.


A very large field of view (4δ x 1δ) with a good spatial resolution owing to the use of four 2k x 2k pixel cameras was conducted in a flat plate boundary layer at two Reynolds numbers (Reθ ≈7,500 and 20,000). Comparing the flow statistics with previously obtained hot-wire data under similar flow conditions show good agreement. The goal of this experiment is to detect and characterise the large scale motions which develop in the log region of a high Reynolds number turbulent boundary layer.


Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect examples to highlight the role played by drug delivery systems in advancing human health. The funda- mentals of LNPs for the delivery of nucleic acid- and mRNA-based therapeutics, are well established. Thus, future research on LNPs will focus on addressing the following: expanding the scope of drug de- livery to different constituents of the human body, expanding the number of diseases that can be targeted, and studying the change in the pharmacokinetics of LNPs under physiological and pathological conditions. This review article provides an overview of recent advances aimed at expanding the application of LNPs, focusing on the pharmacokinetics and advantages of LNPs. In addition, analytical tech- niques, library construction and screening, rational design, active targeting, and applicability to gene editing therapy have also been discussed. acids and mRNAs from LNPs after uptake bycells, in addition to the encapsulation of nucleic acids and mRNAs into LNPs. The LNPs modi fi ed with 1,2-dimyristoyl-rac- glycero -3-methoxypolyethylene glycol-2000 (DMG-PEG) can detach PEG at a moderate rate in the blood circulation, resulting in ef fi cient intracellular delivery of nucleic acids and mRNAs. The uptake of LNPs in the hepatocytes, after the intravenous administration, is caused via the low-density lipoprotein receptor (LDLR) because of the interaction between LNPs and apolipoprotein E (apoE) in the blood.


Abstract. We investigate quantitatively the effect of geomagnetic storms on the sub-ionospheric VLF/LF (Very Low Frequency/Low Frequency) propagations for different latitudes based on 2-year nighttime data from Japanese VLF/LF observation network. Three statistical parameters such as average signal amplitude, variability of the signal amplitude, and nighttime fluctuation were calculated daily for 2 years for 16–21 independent VLF/LF transmitter–receiver propagation paths consisting of three transmitters and seven receiving stations. These propagation paths are suitable to simultaneously study high-latitude, low-mid-latitude and mid-latitude D/E-region ionospheric properties. We found that these three statistical parameters indicate significant anomalies exceeding at least 2 times of their standard deviation from the mean value during the geomagnetic storm time period in the high-latitude paths with an occurrence rate of anomaly between 40 and 50 % presumably due to the auroral energetic electron precipitation. The mid-latitude and low-mid-latitude paths have a smaller influence from the geomagnetic activity because of a lower occurrence rate of anomalies even during the geomagnetically active time period (from 20 to 30 %). The anomalies except geomagnetic storm periods may be caused by atmospheric and/or lithospheric origins. The statistical occurrence rates of ionospheric anomalies for different latitudinal paths during geomagnetic storm and non-storm time periods are basic and important information not only to identify the space weather effects toward the lower ionosphere depending on the latitudes but also to separate various external physical causes of lower ionospheric disturbances.


Your staff will likely ask you about the tragedy at Sandy Hook Elementary. We are the ones they ask for everything, so be prepared for the question "why?"


A differential transmission line structure comprises an insulating layer, a grounded conductive layer laminated to the insulating layer, and a differential transmission line formed in the insulating layer. A region in which the conductive layer is removed is formed in correspondence with a position of the differential transmission line.


We compared endothelial function noninvasively in 15 elderly patients with noninsulin‐dependent diabetes mellitus (NIDDM) with 12 nondiabetic elderly patients. Using high resolution ultrasound, we measured flow‐mediated dilatation (FMD) of the brachial artery and sublingual nitroglycerin (NTG)‐mediated dilatation. FMD was significantly impaired in subjects with NIDDM compared with control subjects. In NIDDM subjects, FMD with complications was lower than in subjects with noncomplications. However, there was no significant difference in NTG between NIDDM subjects and the control group. Hyperemic blood flow change was lower in NIDDM subjects, but not significant. These results suggest that elderly patients with NIDDM have impaired L‐arginine/nitric oxide (NO) pathways and the possibility of capillary rarefaction.


MgO thin films have been deposited on SrTiO 3 and LaA1O 3 substrates using both off-axis rf magnetron sputtering and electron beam evaporation techniques. The effects of substrate material, temperature, film thickness, deposition rate, sputtering gas, and pressure on the quality of the MgO films produced have been studied. Films deposited on (100) SrTiO 3 at temperatures > 300°C display only the (h00) reflections in their X-ray diffraction traces, with narrow X-ray rocking curve measurements indicating that these films are epitaxial. Epitaxy has been confirmed with grazing incidence diffraction. MgO films deposited on (100) LaAlO 3 are crystalline, but have varying orientations depending on the film thickness. From scanning electron microscopy, MgO films on SrTiO 3 substrates appear smooth and dense while those deposited on LaAlO 3 substrates possess rougher surfaces. Surface morphologies have been analyzed using atomic force microscopy.


This study aims to analyze the effect of reward systems and employee motivation on employee performance. The sample obtained was 36 respondents, the sampling technique uses probability sampling, which is a sampling technique that provides equal opportunities for each element (member) of the population to be selected as sample members. . This study uses a census approach, where all members of the population serve as respondents with 36 employees of PT. Wahyu Tehnik Utama. The results showed that there was an effect of the reward system on employee performance. This proves the hypothesis which states that there is a significant influence between the reward system on employee performance and employee motivation has a significant effect on employee performance.


Whether variations in the spatial distribution of erosion influ- ence the location, style, and magnitude of deformation within the Himalayan orogen is a matter of debate. We report new 40 Ar/ 39 Ar white mica and apatite fission-track (AFT) ages that measure the vertical component of exhumation rates along an ;120-km-wide NE-SW transect spanning the greater Sutlej region of northwest India. The 40 Ar/ 39 Ar data indicate that first the High Himalayan Crystalline units cooled below their closing temperature during the early to middle Miocene. Subsequently, Lesser Himalayan Crys- talline nappes cooled rapidly, indicating southward propagation of the orogen during late Miocene to Pliocene time. The AFT data, in contrast, imply synchronous exhumation of a NE-SW-oriented ;80 3 40 km region spanning both crystalline nappes during the Pliocene-Quaternary. The locus of pronounced exhumation de- fined by the AFT data correlates with a region of high precipita- tion, discharge, and sediment flux rates during the Holocene. This correlation suggests that although tectonic processes exerted the dominant control on the denudation pattern before and until the middle Miocene; erosion may have been the most important factor since the Pliocene.


The invention relates to a material for the detection of biological electro-magnetic signals made of a epidermis of a living organism and a diagnostic device using the same, and more particularly, to a material for the detection of biological electro-magnetic signals made of a epidermis of a living organism, through drying is one stage, also selecting is another stage of production, and a diagnostic device using the same. The material of the invention has an effect of detecting biological electro-magnetic signals. Accordingly, the material for the detection of biological electro-magnetic signals of the invention can be used for manufacturing a diagnostic device for detecting biological electro-magnetic signals non-invasively as well as effectively used in diagnosis in cases where biological electro-magnetic signals are changed by cancer, inflammations due to immunodeficiency and so on.


Received: Revised: Accepted: May 17, 2014 February 06, 2015 February 07, 2015 There have been litters of neonatal piglets that died shortly after birth, with a fatality of nearly 100%. The submitted pig had pasty yellowish brown colonic contents and severe mesocolonic edema with distinct suppurative colitis and lymphadenitis. Clostridium difficile toxins were detected and heavy growth of toxigenic C. difficile was yielded in the colonic contents. This strain was characterized by ribotype 078 and had multidrug resistance. A fatal case of porcine enteritis associated with C. difficile in Korea has been described. ©2015 PVJ. All rights reserved


Java applications retrieve memory items as needed. The function of garbage collection (GC) on Java Virtual Machine (JVM) is to automatically determine which memory is no longer in use by the Java system and to deallocate the objects stored in this part of the memory. As memory is restored to JVM automatically, Java developers are not responsible for explicitly deleting unused memory items. We study the performance of various GCs on an Apache Kafka-Storm platform for processing a real-time workload. We demonstrate that the choice of the Garbage collector is sensitive to the configuration of Kafka and the impact of Garbage Collection events on the latency of processing application.


This leaflet is for those patients who suffer from very dry, chapped, itchy or irritated skin. Skin care is very important in order to maintain moisture and keep the skin healthy. To achieve this we recommend using emollients, which are moisturising treatments applied directly to the skin to reduce water loss, and cover it with protective film. Emollients tend to be unperfumed and are available as moisturising creams, ointments, lotions, bath oils, shower products or soap substitutes. They are available in tubs, larger pump dispensers and tubes. Everyone is different when choosing emollients you need to consider what is suitable for your skin.


In this paper, the effect of the polyethylene additive on the tribological and rheological behaviour in EHD lubricated contacts was investigated. The tribological behaviour was studied from two point of view: EHD film-forming properties (in a rolling bearing) and scuffing resistance (on four-ball machine). A semi-empirical method is described to calculate the rheological parameters in EHD contacts by using the traction measurements performed with a two-roller machine. The Eyring stress and shear modulus of the test oils were examined by curve-fitting procedure based on the non-linear viscoelastic model introduced by Johnson and Tevaarwerk. All tests shown that polyethylene in small concentration apparently increases the film thickness, maximum traction coefficient and scuffing resistance.


This research is focused on the identification, assessment, analysis, and evaluation of the impact of the most prominent out of many roadblocks impeding the implementation of Lean-Green and I4.0 practices in manufacturing industries. The research methodology is underpinned by an extensive literature review with expert interventions to make it comprehensive and far-reaching. Further, this exploratory research to address the broad objectives is based on a large sample size, which is validated statistically and empirically for its aptness. A combination of widely used statistical methods is used to converge, assess, analyze, and evaluate the impact of each roadblock individually and in the group on I4.0 implementation in industry. The study prominently depicts lack of organizational leadership, unclear waste management practices, and missing environment-friendly practices as the most prominent roadblocks hindering the progression of Lean-Green and I4.0 adoption. The novel PCA-ISM Fuzzy MICMAC integrated model developed in this research makes this article unique.


We study some basic properties of the Gelfand-Kirillov transcendence degree and compute the transcendence degree of various infinite-dimensional division algebras including quotient division algebras of quantized algebras related to quantum groups, 3-dimensional Artin-Schelter regular algebras and the 4-dimensional Sklyanin algebra.


A new complex with a composition [Bi6O4(OH)4](C7H7SO3)6 is formed on a bismuth plate via electrochemical synthesis at 1.0 V anodic polarization in 0.5 M p-toluenesulfonic acid.


Since years there are constantly appearing reports about a potential myocardial injury induced by intensive sporting activities. The spectacular sudden deaths during marathon, football and, just recently, in the trend discipline triathlon seem to support that view. In addition, reports about the "athlete`s heart" and complications in the elderly causes uncertainty among those, hoping that sporting activity will lead to weight reduction or will improve diabetes or general fitness. Endurance athletes – professionals as well as hobby-athletes – and many sports physicians feel also insecure. Here the mental attitude can make the difference between victory and defeat. The complex issue makes it difficult to give direct answers and recommendations. Some reports capture for themselves having found the answers for "negative cardiac remodeling" caused by sporting activities, partially with spectacular results concerning a right ventricular overload or a left ventricular dysfunction directly after physical activity. This report tries to reflect in a critical way to what extent the statements of these studies are objectively justified, how far sporting activities could be dangerous and what kind of cardiac damage might be expected.


The present invention relates to a method of generating aluminosilicate form of zeolite L, and intermediate and final products of the process. The present invention further relates to the use of aluminum for these hydrocarbon conversion or adsorption.


Simple Summary The DNA of mitochondria can be transferred into the nucleus and form nuclear mitochondrial DNAs (NUMTs). In this study, we identified and characterized NUMTs in genus-wide bumblebee species. The number of NUMTs in bumblebee is much lower than those in its closely related taxon, honeybee. The insertion sites of NUMTs in bumblebee are not random, with AT-rich regions harboring more NUMTs. In addition, NUMTs derived from the mitochondrial COX1 gene are most abundant in the nuclear genome. While the majority of NUMTs seem unfunctional in the bumblebee, some NUMTs show functional clues, which could fuse with their flanking sequences to form novel proteins. Our results shed light on the molecular features of NUMTs and uncover their contribution to genome innovation in the bumblebee. Abstract In eukaryotes, DNA of mitochondria is transferred into the nucleus and forms nuclear mitochondrial DNAs (NUMTs). Taking advantage of the abundant genomic resources for bumblebees, in this study, we de novo generated mitochondrial genomes (mitogenomes) for 11 bumblebee species. Then, we identified and characterized NUMTs in genus-wide bumblebee species. The number of identified NUMTs varies across those species, with numbers ranging from 32 to 72, and nuclear genome size is not positively related to NUMT number. The insertion sites of NUMTs in the nuclear genome are not random, with AT-rich regions harboring more NUMTs. In addition, our results suggest that NUMTs derived from the mitochondrial COX1 gene are most abundant in the bumblebee nuclear genome. Although the majority of NUMTs are found within intergenic regions, some NUMTs do reside within genic regions. Transcripts that contain both the NUMT sequence and its flanking non-NUMT sequences could be found in the bumblebee transcriptome, suggesting a potential domestication of NUMTs in the bumblebee. Taken together, our results shed light on the molecular features of NUMTs in the bumblebee and uncover their contribution to genome innovation.


Japan PAN-based carbon fiber and composite materials(CFRP) have undergone introduction period, growing up period,expending period and formal expending period since 1970 to 2011,while the demand will jump into rapidly expending period during 2012~2020,which will be embodied in rapid development of industrial uses and formal expend in CFRP cars.The CFRP forming technologies in Japan are being affected.Recent CFRP RD achievements of Toray,Teijin,Mitsubishi and other companies and institute were introduced,some new forming technologies and products have word's advanced and leading levels.The development situations of Kurahe and Mitsubishi Resin in developing general pitch-based carbon fiber and mesophase pitch-base carbon fiber and their CFRP were introduced respectively finally.