Summary:  The effect of immunosuppression with dexamethasone on sperm antibody formation following vasectomy in men was determined. Vasectomized men were treated with dexamethasone (4 mg) tablets starting two days prior to vasectomy and each day thereafter for a total of eight days for a total dose of 30 mg. There was no significant difference in serum sperm agglutinating antibody, cholesterol, triglycerides, or lipoproteins between the dexamethasone and placebo groups.


The extent to which star formation varies in galaxies with low masses, low metallicities, and high star formation rate surface densities is not well constrained. To gain insight into star formation under these physical conditions, this paper estimates the ionizing photon fluxes, masses, and ages for young massive clusters in the central region of II Zw 40—the prototypical low-metallicity dwarf starburst galaxy—from radio continuum and optical observations. Discrete, cluster-sized sources only account for half the total radio continuum emission; the remainder is diffuse. The young (≲ 5 Myr) central burst has a star formation rate surface density that significantly exceeds that of the Milky Way. Three of the 13 sources have ionizing photon fluxes (and thus masses) greater than R136 in 30 Doradus. Although isolating the effects of galaxy mass and metallicity is difficult, the H ii region luminosity function and the internal extinction in the center of II Zw 40 appear to be primarily driven by a merger-related starburst. The relatively flat H ii region luminosity function may be the result of an increase in interstellar medium pressure during the merger and the internal extinction is similar to that generated by the clumpy and porous dust in other starburst galaxies.


Enhancing image quality and combining observations into a coherent description are essential tools in various image processing applications such as multimedia publishing, target recognition, and medical imaging. In this paper we propose two novel approaches for image enlargement and image fusion using the Random Neural Network (RNN) model, which has already been successfully applied to the problems such as still and moving image compression, and image segmentation. The advantage of the RNN model is that it is closer to biophysical reality and mathematically more tractable than standard neural methods, especially when used as a recurrent structure.


The Mariscal Sucre Airport in Quito is being relocated and it is place will be taken by a park called Parque del Lago. This park will open up for a new urbanistic proposition on it is surroundings. This project it´s about an urbanistic and architectonic proposition for this part of the city, because it offers a new territorial order located on one side of the Mariscal Sucre Airport. This proposes a new urban design, soil uses and ways of occupation and buildings heights. Therefore the need of implementing a new Center of Commerce with the objective that there would be commercial, social, cultural and entertaining activities, which design allows the equipment integrate to it is surroundings, an innovative idea of centers of commerce in the city where it is possible to interact between users.


Summary Methanolic extract of Feronia limonia (ME) was studied against carbon tetrachloride (CCl4) induced hepatic injury in albino rats and mice. In addition, antioxidant activity was studied by in vitro models. Pre-treatment with ME reduced biochemical markers of hepatic injury like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), bilirubin, cholesterol, high density lipoprotein (HDL) and tissue glutathione (GSH) levels. Similarly pretreatment with ME reduced the CCl4 induced elevation in the pentobarbitone sleeping time. Histopathological observations also reveled that pretreatment with ME protected the animals from CCl4 induced liver damage.ME demonstrated dose dependant reduction in the in vitro and in vivo peroxidation induced by CCl4. in addition it showed dose dependant free radical scavenging activity.The amounts of total phenolic compounds were also determined in this study. The results obtained in the present study indicate that the ME can be a potential source of natural antioxidant and hepatoprotective activity.


Storm runoff amounts from drainage areas of several square miles have often been estimated by direct application of runoff data from small plots and single-cover water-sheds. Data presented here attest to the existence of gains from interflow or quick-return flow on midwest claypan soils under conditions of high antecedent soil moisture. Lesser storm periods with low antecedent moisture conditions show transmission losses on these same areas. For these reasons, weighted plot runoff cannot be accepted as a true representation of watershed runoff. Further evidence of interflow and its evaluation was obtained in 1963 on small irrigated plots at the University of Missouri Experiment Station Farm near McCredie, Missouri. These studies will be continued for another year or two.


Variance estimation is an important research area for sampling statisticians; consequently, if appropriate design variables are provided in the final dataset, nowadays data analysts can calculate variance estimates for most survey statistics via public or custom software. However, some data users are not be familiar with variance estimation procedures or may not have access to software to compute variance estimates under a complex survey design. For this reason, a simple, but useful, approach is to develop approximate variances for statistics of interest. One such technique is called the generalized variance function (GVF) technique. It has been customary to use GVF methods based on (1) design effects or (2) regression models. In this paper, I compare two customary techniques to develop generalized variance estimates. Moreover, I expand the regression model approach to allow an errors-in-variables approach to see whether the resultant GVF estimates perform better than traditional regression-based GVFs.


Two symmetric tilt grain boundaries (GBs) (Σ3〈110〉{112} and Σ11〈110〉{332}) in alpha iron were performed to investigate the dynamics of defect-loaded GBs under shear deformation. The results show that the loaded self-interstitial atoms (SIAs) reduce the critical stress of the coupled GB motion in the Σ3 GB, but increase the critical stress in the Σ11 GB. The loaded SIAs in the Σ3 GB easily form 〈111〉 clusters and remain in the bulk when the GB moves away. However, the SIAs move along with the Σ11 GB and combine with the vacancies in the bulk, leading to the defect self-healing. The helium (He) atoms loaded into the GBs significantly affect the coupled GB motion. Once He clusters emit interstitials, the Σ11 GB carries those interstitials away but the Σ3 does not. The loaded He atoms reduce the critical stress of the Σ3 GB, but increase the critical stress of the Σ11 GB.


Theologically informed positions are grounded in core beliefs and may be rationally discussed. We analyze Dr. Norko's suggestion on how, in the public square, to address moral disagreements. We point out the dangers of "deliberative democracy" as an approach to resolving conflicts over basic values. We suggest an alternative approach, better grounded in reason, as a way of bringing religious and secular views into a discussion of the death penalty.


Heatwaves are defined as a set of hot days and nights that cause a marked short-term increase in mortality. Obtaining accurate estimates of the probability of an event lasting many days is important. Previous studies of temporal dependence of extremes have assumed either a first-order Markov model or a particularly strong form of extremal dependence, known as asymptotic dependence. Neither of these assumptions is appropriate for the heatwaves that we observe for our data. A first-order Markov assumption does not capture whether the previous temperature values have been increasing or decreasing and asymptotic dependence does not allow for asymptotic independence, a broad class of extremal dependence exhibited by many processes including all non-trivial Gaussian processes. This paper provides a kth-order Markov model framework that can encompass both asymptotic dependence and asymptotic independence structures. It uses a conditional approach developed for multivariate extremes coupled with copula methods for time series. We provide novel methods for the selection of the order of the Markov process that are based upon only the structure of the extreme events. Under this new framework, the observed daily maximum temperatures at Orleans, in central France, are found to be well modelled by an asymptotically independent third-order extremal Markov model. We estimate extremal quantities, such as the probability of a heatwave event lasting as long as the devastating European 2003 heatwave event. Critically our method enables the first reliable assessment of the sensitivity of such estimates to the choice of the order of the Markov process. H.C. Winter, J.A. Tawn Department of Mathematics and Statistics, Lancaster University, Lancaster, LA1 4YF, U.K. Present address: of H.C. Winter EDF Energy R&D UK Centre, Cardinal Place, 80 Victoria Street, London, SW1E 5JL, U.K. E-mail: firstname.lastname@example.com 2 Hugo C. Winter, Jonathan A. Tawn


A computational algorithm is presented for the extraction of an optimal single linear feature from several Gaussian pattern classes. The algorithm minimizes the increase in the probability of misclassification in the transformed (feature) space. The general approach used in this procedure was developed in a recent paper by R. ft. P. de Figueiredo. ~1) Numerical results on the application of this procedure to the remotely sensed data from the Purdue C1 flight line as well as LANDSAT data are presented. It was found that classification using the optimal single linear feature yielded a value for the probability of misclassification on the order of 30 ~ less than that obtained by using the best single untransforrned feature. The optimal single linear feature gave performance results comparable to those obtained by using the two features which maximized the average divergence. Also discussed are improvements in classification results using this method when the size of the training set is small.


RFID technology constitutes an important part of what has become known as the IoT; i.e accessible and intercon nected machines and everyday objects that form a dynamic and complex environment. In order to be able to secure the IoT in a cost-efficient manner we need to build security and privacy into the design of its components. Thus, in this paper, we firs t introduce the use of security and privacy policies that can o ffer fine granularity and context-aware information control in R FID systems, and with this in mind, we propose a novel secure and privacy preserving tag management protocol to implement su ch policies. The new protocol has a modular design in order to support all the basic management operations (tag authentic ation, delegation and ownership transfer), while imposing minimal hardware and computational requirements on the tag side.


Probability as logic is used to estimate the surface velocity of a patch of soil driven by an incident acoustic wave. The data used by the estimation procedure is obtained from a laser Doppler vibrometer (LDV). The output of the LDV is an intermediate-frequency carrier that is frequency- modulated by the soil surface velocity. Additionally, the LDV output is amplitude modulated by an undesirable variation in the returned laser signal due to dynamic optical speckle. The effect of the amplitude modulated by an undesirable variation in the returned laser signal due to dynamical optical speckle. The effect of the amplitude modulation on the estimate of the soil surface velocity is illustrated with results obtained using the Markov chain Monte Carlo method.


Introduction: Breastfeeding is one of the most effective ways to ensure child survival. Around 8,20,000 child lives would be saved every year if breastfeeding were scaled up to approximate universal levels 3. In Qatar, exclusive breastfeeding for children age 0-5 months was 29.3%. However, there is no updated data or data at the level of community affiliated to primary health care centres in Qatar. Methodology: Data on women breastfeeding practices was extracted from Cerner at their well-baby clinics visits at four health centres between 1st of January 2017 and 31st of August 2019. Deceased patients and registered ones with expired residency at the 31st of August 2019 cut-off point in time were excluded. Results: At Leabaib HC, exclusive breastfeeding was 19.9% (6.7% Qataris, 33.7% non-Qataris) and 9.2% at 4 months and 6 months, respectively. At Airport HC, exclusive breastfeeding at 4-month visit point was 11.5% and 34.9% among Qatari and non-Qatari women, respectively. At Al Shamal HC, no Qatari women reported any exclusive breastfeeding practices at 6 months, while only 7 non-Qatari women reported that, and 4 Qatari women reported exclusive breastfeeding at 4 months. At Al Jumailiya HC, only 4 women (2 Qataris, 2 non-Qataris) reported exclusive breastfeeding at 6 months and 5 Qatari women reported exclusive breastfeeding at 4 months. Implications: The results will allow tailoring more effective measures to promote breastfeeding, namely among Qatari women. Conclusion and recommendations: Exclusive breastfeeding practice rates at 4 and 6 months were low among all nationalities registered at the 4 health centers. However, the lowest rates were among Qatari lactating women at 6 months. Hence, breastfeeding promoting initiatives should be applied and more in-depth qualitative techniques are needed to understand the reasons for the low rates, namely among Qatari women.


Background: Voice and swallowing problems are frequently associated with thyroidectomy. Intermittent nerve monitoring (i-IONM) seems to provide a positive effect in reducing its prevalence. The aim of this study was to test the hypothesis that continuous intraoperative nerve monitoring (c-IONM) may reduce the prevalence of these disorders even further than i-IONM. Methods: This 3-arm prospective bi-institutional study compared 179 consecutive patients that underwent thyroidectomy: 56 without IONM, 55 with i-IONM and 67 with c-IONM. Neck dissections and laryngeal nerve palsies were excluded. Two questionnaires (VHI-10 for voice disorders and EAT-10 for swallowing disorders; both validated for Italian language use) were administered before and 1 month after surgery. Statistical significance was analyzed by the chi-squared test. Results: After thyroidectomy, no statistically significant differences were found in the three groups concerning EAT-10. although these symptoms seemed to be influenced by gastro-esophageal reflux. VHI-10 worsened in the "no-IONM" group compared with both i-IONM (p < 0.09, not quite statistically significant) and c-IONM (p < 0.04). Conclusion: Both i- and c-IONM improve voice quality independently of laryngeal nerve integrity. Reduced dissection and particularly restrained manipulation could explain these results, being particularly favorable for c-IONM.


In view of the problem that aero engine control system sensor fault detection easily causes mistake in strong noise condition,this paper designs a sensor fault detection method based on modulus maxima.The theory of detecting fault by wavelet singularity is first introduced,then the modulus maxima caused by noise is determined according to the Lipschitz.The detection algorithm based on modulus maxima theory for typical sensor fault is given,and the fault detection is simulated using wavelet modulus.The simulation results of turbofan engine control system sensor fault show that the character of singularity can be described strictly by wavelet transform,and this method is effective on dliminating noise.


Objective
To investigate the clinical effect of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in the treatment of primary liver cancers of high-risk sites.

Methods
Clinical data of 100 patients with primary liver cancers of high-risk sites from April 2013 to April 2018 were analyzed retrospectively. According to different therapeutic treatments, 100 patients were divided into TACE group (50 cases) and Combined group (50 cases). Patients in TACE group received TACE, while patients in Combined group underwent both TACE and RFA. Statistical analysis were performed by using SPSS18.0 software. Count data such as 1-year survival rate, short-term outcome and postoperative complications were analyzed by using χ2 test. Measurement data such as AFP and KPS were represented as (±s) and were examined by using t test. A P value of < 0.05 was considered as statistical significant difference.

Results
Short-term curative effect in Combined group was significantly higher than that in TACE group (P 0.05). After operation, AFP in Combined group was much lower than that in TACE group (P<0.05), while KPS in Combined group was much higher than that in TACE group (P<0.05). The incidence of abdominal pain in Combined group was higher than that in TACE group (P<0.05), however other adverse reactions were lower than those in TACE group respectively (P<0.05).

Conclusion
TACE combined with RFA is better than TACE alone in the treatment of primary liver cancers of high-risk sites, with improved survival of the patients. The combined treatments have application value for patients with unresectable primary liver cancers, and it is worth of clinical promotion.

Key words:
Carcinoma, hepatocellular; Hepatectomy; Ablation techniques; Transarterial embolization


The title molecule, C15H8ClNO2, is essentially planar. The molecular packing in the crystal is stabilized by weak intermolecular C—H⋯π interactions and van der Waals forces.


Through the analysis on the characteristics of wind power in Northwest power grid,the necessity to construct large-scale pumped storage power station is put forward.Through the introduction of excellent geological geographic features of Qinling Northern Piedmont,it is proposed to construct large-scale pumped storage power station at northern piedmont of Qinling for satisfying the requirements of future safe,stable and economic operation of Northwest power grid.


We investigate the multicast throughput of asymmetrical butterfly network which consists of two sources, two destinations and a half-duplex relay, where each destination needs to decode the data from two independent sources. In order to reduce processing complexity and multiple interference, other nodes should keep silent when the relay transmits signals. We first present an explicit expression of the deterministic maximal multicast throughput by using Avestimehr, Diggavi and Tse's deterministic approach. With the insight of the obtained result, we put forward a near-optimal network coding strategy to approach the maximal multicast throughput of this network. Finally, we compare our achievable rate region with an outer bound and show the gap between them is less than a constant 2.45 bits in some cases.


An in-depth secondary emission characterization for metal additive manufactured samples has been performed to assess the impact of the surface roughness in this parameter. Three samples has been 3D printed, post-processed with two different treatments and tested. The results shown a secondary emission improvement with considering as-built parts while is getting closer to the flat aluminum surface values when a post-process for improving the surface roughness is applied. The roughness from additively manufactured surfaced could be exploited to reduce the surface secondary emission and, hence, to increase the power for multipactor discharge.


This longitudinal case study examines four new FSL teachers' beliefs regarding the best and worst FSL program for English language learners and students with learning difficulties; the data are drawn from qualitative semi-structured interviews that occurred at the end of the participants' Bachelor of Education program and near the end of each school year of their first three years of teaching. The case study considers how the teachers did or did not change their views as they gained experience in the classroom.


Objec vity in news discussions con nue over many years. Many and various rules were formed as a result of studies that were conducted so that the news on papers would refl ect to reality and the journalis ts would be objec ve. The commercial aspect of journalism and the pressure groups and forma ons that aff ect the process of news produc on lead to the limited opportuni es in the terms of achieving objec vity in news. This concept which is on the agenda again with the advent o he Internet has been controversial. This ar cle focuses on the concept of objec vity in news and journalism in the internet as an example of objec ve structures is inves gated. It uses qualita ve research design. In Turkey, the most clicked on 14 news siteas the sample are taken. The fi rst fi ve of these sites are the extensions of sites of newspapers. These sites con nue the objec vity of newspapers. It is seen that there are news from these different internet sources when the news sites are examined. Because these news are spread instantly and very fast to the sites, there is no way of verifi ca on. For this reason, the objec vity of the internet news sites is more controversial than the newspapers.


The calibration of an imaging spectrometer by using the diffuser method should consider not only the accuracy of calibration instruments,but also the effects of instrument and geometric parameters from the imaging spectrometer on calibration results.According to the calibration principle of imaging spectrometer using the diffuser method,this paper deduces the expression of the collected signal electron number in each spectral channel of the imaging spectrometer by taking the parameters as self-variables, and it analyzes the effects of the incident angle of standard lamp,the distance of standard lamp to the diffuser,the slit direction and the observation incident angle of the imaging spectrometer on the electron number collected by the detector pixels.The results show that when the F number is set to be 3 and 4,the entrance pupil in 0.1-0.2 m,the standard lamp illuminating angle less than 12° and the distance of the standard lamp in 0.5-2 m,the change of the signal electron number can be less than 1%.It satisfies the accuracy need of the calibration by using the diffuser method.


Submitted for the DFD09 Meeting of The American Physical Society Tear Film Dynamics for Blink Cycles with a Wetting Cornea and Evaporation R.J. BRAUN, J. TANG, L.P. COOK, University of Delaware, D.M. ANDERSON, George Mason University — We consider a lubrication model in one spatial dimension for the human tear film. The ends of the domain move to mimic the blink cycle of the eyelids; the underside of the film is wettable surface due to a conjoining pressure and evaporation occurs from the top surface of the film. The film can equilibrate at a small finite thickness where the conjoining pressure and evaporation balance. This small thickness is interpreted as a dry spot; the model can compute past dry spot formation. Results are given for the film dynamics with either pressure of flux boundary conditions on the ends of the film. The film can form dry spots for some boundary conditions of either type. The persistence of the dry spots with respect lid motion and other effects are explored. Richard Braun University of Delaware Date submitted: 11 Aug 2009 Electronic form version 1.4


This paper discusses the evaluation of a structure with severely embrittled steel. The problem of continued use of embrittled structural steel is addressed. The means available for performing an evaluation are listed.


Nonstationary inverse problems are usually cast in the state-space formalism. The complete statistics of linear Gaussian problems can be computed with the Kalman filters and smoothers. Nonlinear non-Gaussian problems would necessitate the adoption of particle filters or similar computationally very heavy approaches. The so-called extended Kalman filters often provide suboptimal but feasible estimates for the nonlinear problems. Several applications which lead to nonstationary inverse problems are time critical, such as process tomography and many biomedical problems. In such applications, there is typically a need to use reduced-order models which may heavily compromise the computational accuracy that is usually required for inverse problems. One approach to overcome the model reduction problem is to use the approximation error analysis. In this paper, we derive the equations for the extended Kalman filter for nonlinear state estimation problems in which the approximation error models are taken into account. We consider the approximation errors that are due to both state reduction and time stepping. As an example, we consider the identification of the coefficients of the heat equation. Our main result is that, also in nonlinear problems, approximation error analysis allows us to obtain accurate estimates and uncertainties of the parameters in reduced-order models that are suitable for fast calculation.


Sialic acid (Sia) is a group of acidic sugars with a nine-carbon backbone, and classified into three species based on the substituent group at C5 position: N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic acid (Neu5Gc), and deaminoneuraminic acid (Kdn). In Escherichia coli, the sialate aldolase or N-acetylneuraminate aldolase (NanA) is known to catabolize these Sia species into pyruvate and the corresponding six-carbon mannose derivatives. However, in bacteria, very little is known on the catabolism of Kdn, compared with Neu5Ac. In this study, we found a novel Kdn-specific aldolase (Kdn-aldolase), which can exclusively degrade Kdn, but not Neu5Ac or Neu5Gc, from Sphingobacterium sp., which was previously isolated as a Kdn-assimilating bacterium. Kdn-aldolase had the optimal pH and temperature at 7.0-8.0 and 50 °C, respectively. It also had the synthetic activity of Kdn from pyruvate and mannose. Site-specific mutagenesis revealed that N50 residue was important for the Kdn-specific reaction. Existence of the Kdn-aldolase suggests that Kdn-specific metabolism may play a specialized role in some bacteria.


We examine the relationship between various measures of institutional ownership and investee firms' level of innovation as measured by the number of patents and patent citations. We find a direct association between the stability in the equity ownership of institutional investors and their investee firms' level of innovation. Our main finding would serve to reassure managers that they benefit from the support of long-term-oriented institutional investors who adopt a "buy and hold" investment philosophy as opposed to a "trading" philosophy. We also examine the association between the proportion of a firm's equity held by institutional investors and its innovation and find that it relies on the type of the investor. For instance, while there exists a positive association between mutual funds and firm innovation yet, the association is only positive for funds that actively manage their portfolios different from their benchmark index. Next, pressure-sensitive institutional investors' shareholdings are positively correlated with firm innovation; however, it is not necessarily the case for all the pressure-insensitive investors.


The relationship of the twentieth century to the Enlightenment is complex but overall negative. Often associated with philosophical positivism and the conviction that scientific methodology can explain everything, the Enlightenment is considered an essentially flawed "project" from its very beginning (as if the Enlightenment is a person with a will to design a project). Political movements from the earlier part of this century were determined to replace its legacy with their own alternatives. Philosophers from both the political Right and Left, from Horkheimer and Adorno to Foucault and Gadamer, seem to think that their counterparts two hundred years ago had nothing else in their mind than busily laying the groundwork for the political and environmental disasters of our time. Neither have postmodernists lost any love on the Enlightenment although it is curious to note that today's antifoundationalists have such an essentialist view of the Enlightenment. True, under the slogan of enlightenment about the Enlightenment it is sometimes argued that insofar as criticism was its structural characteristic, criticizing the Enlightenment means that for instance Nietzsche or Foucault can be seen as following its tradition. There is something to this argument, although not much, and in any case the effect of denouncing the eighteenth-century Enlightenment is the same. Most peculiar about the Enlightenment's detractors is that they seem to know exactly what it was all about.


Emerging market debt has consistently outperformed emerging market equities, and this trend is likely to continue. Although the emerging market debt asset class has a positive secular trend, the cyclical outlook is challenging. In approaching this asset class, investors who focus on the fundamentals should be able to identify enough quality credits to obtain significant return and downside protection.


Research on the safety culture of aviation maintenance organization is weak compared to one of the aviation flight organization. This reality is a situation that worked the effort systematically to reduce the risk factors that are caused by the aircraft maintenance actions and thus it is true that it is a situation where the environment is concerned and can be causing more accidents and serious incidents. The aim of this study was to derive improvement strategy by evaluating the safety culture of aviation maintenance organization and by analyzing the poor part of it. Made on the basis of the five aspects of safety culture, the reliability of the questionnaire by Cronbach's Alpha coefficients of .92 is very high and the results of the evaluation of the safety culture level of aviation maintenance organization evaluated by the bureaucratic level.


Quantum field theory on rotating black hole spacetimes is plagued with technical difficulties. Here, we describe a general method to renormalize and compute the vacuum polarization of a quantum field in the Hartle–Hawking state on rotating black holes. We exemplify the technique with a massive scalar field on the warped AdS3 black hole solution to topologically massive gravity, a deformation of (2 + 1)-dimensional Einstein gravity. We use a "quasi-Euclidean" technique, which generalizes the Euclidean techniques used for static spacetimes, and we subtract the divergences by matching to a sum over mode solutions on Minkowski spacetime. This allows us, for the first time, to have a general method to compute the renormalized vacuum polarization, for a given quantum state, on a rotating black hole, such as the physically relevant case of the Kerr black hole in four dimensions.


This paper has analyzed the current situation of the farmers information quality,and points out the necessity of strengthening the farmer information quality education,also points out the ways of Agriculture libraries in strengthening the farmer information quality education.


DC filter components and devices in converter stations of a high voltage DC transmission project may withstand a certain amount of transient overvoltage due to the impact of transient impulses.In order to protect them,suitable arresters should be equipped properly in the filters to limit the transient overvoltage to an acceptable level.By utilizing the method of DC filter simulation and transient calculation model,the paper studies the transient overvoltage in the DC filters of the Jinping-Sunan ultra high voltage direct current(UHVDC) transmission project under the most severe transient operation conditions.Three arresters are installed inside each filter,which consequently decide the insulation levels of the filter component: mainly capacitors,reactors and resistors.The lightning impulse insulation levels for the high voltage reactors of the two filters are 648 kV and 788 kV respectively,while they are 464 kV and 627 kV for the low voltage reactors,and 648 kV and 788 kV for the resistors.The insulation level for the high voltage capacitors is no more than 815 kV.The calculation results provide basis for choice of the DC filter components.


PURPOSE: To control the direction of an antenna with a simple constitution by setting the antenna maintained at a prescribed elevation angle to the azimuth at which the signal intensity becomes maximum based on positional information after installing the antenna by correcting the inclination of the antenna from the horizontal plane and vertical line. CONSTITUTION: After an antenna system 6 is installed by correcting the inclination of the system 6 from the horizontal plane or/and the vertical line by means of an installation correcting means 7 before using the system 6, a central processing unit (elevation angle computing means) 2 decides the elevation angle of the antenna 6 based on positional information S1. An elevation angle controller 4 gives a prescribed elevation angle to the antenna 6 based on elevation angle information S2 from the unit 2. Then the unit (azimuth deciding means) 2 inputs receiving signal intensity information S8 which gives the maximum measurement result of a received signal intensity measuring instrument 9 obtained by the instrument 9 by measuring the signal intensity of received broadcasting signals S5 from the antenna 6 while the antenna 6 is rotated one turn in the horizontal direction and decides the azimuth corresponding to the information. Then the unit 2 controls the azimuth of the antenna 6 by giving rotation control information S3 to an azimuth controller 5. COPYRIGHT: (C)1993,JPO&Japio


A commercial PVC sample was chlorinated in water suspension under UV irradiation. The chlorine content increased gradually from one to two chlorine atoms per monomer unit indicating an apparent saturation. No significant degradation of the polymer occurred. High resolution NMR-analysis showed that the initial stage of the reaction was a formation of CHClCHCl-groups. At later stages CH2CCl2-groups were also formed but not adjacent to each other along the chains.


Abstract It is likely that 90% of all small-molecule high-performance liquid chromatography (HPLC) separations can be done with a hydrocarbon-bonded phase of C4, C8, or C18 length using various mobile phases. The remaining 10% of the cases are more challenging. One solution is to follow the historical path of gas-liquid chromatography and create more bonded phases. The second and more easily done is to add components to the mobile phase that interact selectively with the molecules of interest and change RPLC selectivity and retention. This paper begins with a generalized discussion of additive strategy and mechanism and then leads to a study of nonionic but coordinatively unsaturated (β-diketonates as additives which serves as an example of the connection between molecular chemistry and chromatographic selectivity and a review of other work done. A system of coordinatively unsaturated metal β-diketonates was investigated as mobile phase additives for HPLC. Unlike previous ionic, metal dopants, these neutr...


The COVID-19 pandemic has created a shortage of ICU beds and ambulances in Sri Lankan hospitals, leading to overcrowding and patient discomfort. There is a pressing need for diverse data and information to make swift decisions and ensure efficient patient transfers amid the limited availability of ICU beds and ambulances. Ambulances are primarily owned by private hospitals in urban areas, while many hospitals in Sri Lanka lack sufficient ICU beds and facilities. To address these challenges, a proposed mobile platform aims to forecast ICU bed requirements by connecting all government hospitals and ambulances. Powered by AI and utilizing machine learning models, the platform predicts the number of beds needed and records comprehensive ICU-related data. This solution improves the efficiency of medical staff, reduces the risk for critically ill patients, and ultimately lowers the mortality rate, driving the paradigm shift towards achieving Health 4.0 in the healthcare operation model.


A Thesis Submitted To The School Of Graduate Studies Of Addis Ababa University In Partial Fulfillment Of The Requirements For The Degree Of Master Of Science In Paleontology And Paleoenvironment


The history of trying to interact between the speaker and the listener in performing arts began from B.C. Through simple questions and answers, it induced viewers to participate, caused them to focus on the story, and induced a natural flow of conversation. But with the development of film invention and video technology, the interaction between producers and viewers has become less active, less passive or less interactive. If games and movies are combined with many elements of interaction, it can be a new attempt, and there is a high possibility that this interest and exposure will soon be linked to the formation of a new game genre. It can also increase the user's immersion and generate interest to meet their commitment to re-watch. To this end, this study explores ways to solve and improve the problems of existing interactive movies through case studies and effectiveness analysis of attempts to fuse games and movies, including existing interactive movies.


We apply the concept of -polar fuzzy sets to graph structures. We introduce certain concepts in -polar fuzzy graph structures, including strong -polar fuzzy graph structure, -polar fuzzy -cycle, -polar fuzzy -tree, -polar fuzzy -cut vertex, and -polar fuzzy -bridge, and we illustrate these concepts by several examples. We present the notions of -complement of an -polar fuzzy graph structure and self-complementary, strong self-complementary, totally strong self-complementary -polar fuzzy graph structures, and we investigate some of their properties.


FMS is the core of the modern airborne electronic systems. It plays a top level control and coordinating role in the FMS is the core of the modern airborne electronic systems. It plays a top level control and coordinating role in the aircrafts. The development of the aircraft FMS, system composition and interactions between modules are concluded systematically. The key technical issues of architecture design, system test and evaluation, the trajectory optimization and precise navigation on FMS are studied in depth. aircrafts. The development of the aircraft FMS, system composition and interactions between modules are concluded systematically. The key technical issues of architecture design, system test and evaluation, the trajectory optimization and precise navigation on FMS are studied in depth.


The discrete choice modeling framework plays a dominant role in travel demand modeling. It is particularly suitable for choices with a compact choice set, such as mode choices. However, for spatial choices such as route or destination choices, which are in general characterized by a large number of alternatives, the choice set formation step poses crucial and to date unsolved methodological and empirical problems. This online survey provides data for stepping towards solving these important problems. The publicly available Web-based tool enabling an empirical approach to destination choice set formation is publicly available.


This paper introduces a practical methodology of assignable signals and Run chart tests for identification of nonrandom patterns of supplier performance by statistical monitoring. The assumption of normal distribution is one of the important factors to implement a control chart in industry and service. It is supposed that natural data shows lack of any nonrandom pattern signals or out of control points on control chart. The data of supplier's on-time delivery for automotive industry has been gathered and illustrated on control chart by employing appropriate transformation and assignable signals and run chart were tested on the control chart accordingly. The results show that tests were able to identify nonrandom patterns of supplier performance data. Out of control signals were removed from the control chart and show that on-time delivery performance was increased accordingly. The control chart with natural pattern can be used as pilot for monitoring supplier delivery over time and improve supplier delivery performance. [Journal of American Science 2010;6(4):114-122]. (ISSN: 1545-1003).


This is a report on a patient with the karyotype 46, XX, -13, +r(13), and a review of the literature on the ring 13 (r13) chromosome. We have used two computerized data bases for a search of information on the r (13) chromosome syndrome. We have analyzed the data on 39 patients (subjects) all of whose karyotypes included r (13). We have especially searched for helpful data for physical features and counseling of families in whom this subject may appear: multiple birth defects, natural history, management problems, and correlation with cytogenetic results. The 39 cases reviewed here, which include r (13) in the karyotypes, correlate best with Niebuhr's Category I of 13q-subjects, and in a few instances, with Category II. Occasional cases have features of Trisomy 13.


In Vietnam, there are various types of bananas, some of them have become regional specialties of many regions such as: Pink Pepper banana, Western banana, King banana, old banana, etc. Nowadays, Pink Pepper banana is the most popular grown banana with high potential for domestic and international markets. In order to contribute to adding value to agricultural products, linking production along the value chain for Pink Pepper bananas is an urgent issue for policy makers as well as businesses and farmers. This article focuses on analyzing the current status of value chain production linkage for this specific type of bananas in Yen Lac District, Vinh Phuc Province, Vietnam, at the same time, showing results, limitations, causes and recommendations to promote production linkages in the value chain for Vietnamese Pink Pepper banana products in the context of world economic integration.


The desire of every academic is to publish in reputable national and international journals. Unfortunately, this desire more often than not turn out to be a nightmare particularly for academics in developing economies, whose research outputs are usually rejected at initial desk review. Such research outputs generally end up with predator journals that have no formal peer-review process, but are primarily set up for profit maximization. Consequently, the scholarly contributions of such academics remain very meagre, and almost unnoticeable. To halt this trend, this paper identifies nine (9) pitfalls common among economic researchers in developing economies and proffers possible solutions for overcoming them so that their future research efforts can add value to the body of knowledge.


The most basic task of any file system is to manage and organize data in a storage volume. Each file in the store is allocated a list of blocks (the basic unit of access), and when we access a file, the system retrieves the data in sequence from the list. Correspondingly, removing the relevant entry deletes the item (note that in most systems, deleting simply means that data is overwritten over time by newly saved files, rather than actually removed). Figure 1 depicts the layout of files distributed across blocks of a storage medium, and provides a simplified view of the data structure used to track allocated blocks. When the information for a volume is corrupt or missing, it is only possible to recover files by analyzing the fragmented raw data, a process known as file carving. Today, file-carving tools play an important role in digital forensic investigations, where analyzing deleted files and salvaging data from damaged and faulty media are common procedures. However, when files are encoded and compressed (as with most multimedia files), recovery is dependent on the availability of the file header, which includes all the decoding parameters. If a file is partially intact with its header deleted, common carving techniques cannot recover any data. Here, we describe an algorithm1 that advances the latest developments in JPEG carving by introducing the ability to recover file fragments when the associated header is missing. There are two main challenges associated with file carving. The first is the inability to lay out data blocks contiguously on the storage, as in the case of files b and f in Figure 1. Repeated execution of file operations, such as addition, deletion, and modification of files, over time leads to fragmentation of available free storage space. As a result, the newly generated files need to be broken into several parts to fit into the available unallocated blocks. Figure 1 illustrates this phenomenon, where files a and c are separated into two pieces. Even the new solid-state drives Figure 1. Distribution of data blocks on an information storage volume and the corresponding file allocation table.


Torsion of the gall‐bladder in 2 women in the tenth decade of life is described. The aetiology of the condition is discussed and the importance of keeping the diagnosis in mind in this age‐group is stressed.


The conception of the space electromagnetic launch is to use electromagnetic propulsion technology to accelerate a space launch vehicle on the ground to supersonic speed, which can reduce the takeoff quality and cost of the space launch vehicle. High-temperature superconducting linear synchronous motors (HTS-LSMs) are promising in space electromagnetic launch applications with the advantages of high thrust density, high efficiency, large electromagnetic gap, and liquid-helium-free cooling. Adopting on-board solid-nitrogen (SN2) cooled HTS mover magnets is one method to overcome the constraints of space limitation and weight reduction. To examine the thermal stability of SN2-cooled mover magnets, this article aims to study an HTS magnet as the mover magnet of an HTS-LSM using static and dynamic tests, including refrigeration tests, excitation tests, cryocooler turned-off tests, and electromagnetic vibration tests. The static test results show that the magnet could be cooled to below 27 K and excited to 246 A. The dynamic test results show that the magnet could withstand a vibration environment of up to 11.14 gRMS without quenching and structural damage. This article provides useful information for the design and application of an on-board SN2-cooled HTS-LSM mover magnet.


Disappointing to many, however, is the fact that the massive reform which secondary schools have experienced has altered the college and university programs but little. This has had a particularly unfortunate effect on FL teacher education programs because undergraduates continue to be taught languages by traditional methods in many colleges. Furthermore, methods courses are generally weak or non-existent.


It can be seen that the use of musictherapy as a tool for the treatment of other conditions has been over the history of mankind has been widely used. In the first instance, consider him as part of a magical process - religious, and therefore allowed him to communicate with the world of gods and spirits, then, was regarded as the via regia to the world beyond. As the ancient civilizations evolved in their thinking processes, and therefore increasingly gave more value to the rational - logical, and then change as the music was conceived as a tool in the treatment of patients; but was not, not until the ancient Greeks could reach the pinnacle of the development of music as a form of treatment in antiquity.


The Beta‐2 Adrenergic Receptor (β2AR) is a G‐protein coupled receptor (GPCR) which, when stimulated by a catecholamine, causes the relaxation of various smooth muscles, and the production of glucose by glycogenolysis and gluconeogenesis. Pharmaceuticals acting though β2AR are important for treating asthma, chronic obstructive pulmonary disease (COPD), and premature labor. The structure of β2AR consists of 7‐transmembrane domains, connected by three extracellular loops and three intracellular loops. At the base of the extracellular loops, buried within the transmembrane helices, there is a predominately hydrophobic binding pocket with several crucial polar residues that interact with ligands. Interestingly, certain polar interactions appear to play a role in the conversion of the receptor from an active to an inactive state. Recent crystallography of β2AR has revealed that the active state, relative to the inactive state, shows only minor changes in the binding pocket, whereas critical shifts occur at the cytoplasmic face. These conformational changes lead to a dissociation of the G‐protein from the receptor, which then initiates a signaling cascade. The Hostos‐Lincoln Academy SMART team (Students Modeling A Research Topic) modeled ligands in complex with β2AR using 3D printing technology. Supported by grants from the HHMI Precollege Program and the Camille and Henry Dreyfus Foundation.


1. The Relentless Champion 2. Destined to Lead 3. The Recovering Perfectionist 4. The Duality Within 5. The Demon Slayer: Conquering a Dark Side of Difference 6. A Mid-Life Reinvention 7. Fighting the Force of Old Habits 8. The Reluctant President 9. The Reluctant President Revisited 10. On Making the Transition from Executive Coach to Trusted Advisor 11 . The Case Studies: A Comparison of Client/Trusted Advisor Perspectives Coda: As to the Future...


Background. The process of social capital formation as a full-fledged scientific theory reflects and explains important social processes. Constant communication and socialization process make new demands on the economy and economic mechanism. Now there are clear periods of technological change for which humanity at the subconscious level is ready and needs it. Most of these processes took place due to the constant functioning of social capital. The aim of the article is to identify and periodize the main stages of evolution of the social capital concept based on the study of its origin nature, and characteristics of key points that influence further theory process, definition of basic features and structure of social capital. Materials and methods. The works of foreign and domestic scholars on social capital were studied to solve this goal. Methods of historical and logical generalization, analysis and synthesis, comparison and generalization were used in the paper. Results. A significant amount of works on this concept has become a prerequisite for identifying and periodizing the evolution stages of the social capital concept: latent, conceptualization, the stage of convergence and pragmatization. The following approaches to the interpretation of social capital were formed in the second stage: sociological, historical, economic, institutional, political science and symbiotic. The study has confirmed the third stage of development of the social capital theory lasts, which is characterized by significant achievements in understanding its content and role in society, practical implementation of certain methodological provisions, on the one hand, and active discourse and pluralism of views on the social capital concept on the other hand. Conclusion. Historical retrospection of the formation process of the social capital concept, analysis of scholars' views on its essence, their synthesis and development have allowed to determine the following main essential characteristics of the "social capital" concept and form its author's vision as a set of social institutions, relations, norms, values, mutual trust structure. Its parameters affect the formation of other capital forms, management models and benefits in general, which are characterized by interconnectedness with human capital and the historical and cultural development context and management object. Keywords: social capital, trust, communication network, norms, institutional environment.


A number of amendments to the Clean Air Act have been proposed. The subjects of these amendments can be divided into five major themes: ozone and carbon monoxide nonattainment; acid rain; municipal waste incineration; toxic air pollutants; and are air quality standards tight enough to protect public health This paper discusses these themes and the possible environmental impact of amendments based upon them.


@bryanwoods Might just have to give the research librarian a challenge tommorow, according to this article it is 1958 purchasing software from the military: https://www.technologyreview.com/s/538966/what-is-the-oldest-computer-program-still-in-use/


Some variational models have been recently introduced to the aim of modeling ramified structures, such as trees, rivers and so on. We introduce a general scheme in which the notion of transport distance is introduced starting from a general transport cost functional, through relaxation arguments. Then we apply this general framework to the irrigation cost, which is a particular cost functional depending on a parameter α ∈]0, 1[. We discuss the equivalence between this abstract approach and the above models.


This paper makes a theoretical intervention into debates on governance from a feminist psychosocial perspective. Its key claim is that the distribution of power and emotion are intimately connected in governance. Indeed, emotions are productive of power in the sense that they constitute part of the means by which the state comes to be, they are integral to its gendered and raced orderings and are in turn part of the means by which the state enacts gendered and raced power. In the paper I outline how the ideas of intersectionality, relationality and feeling work can, when taken together and connected to understandings of experience and subjectivity, enable an analysis of the everyday practices of policy making and governance. I call these everyday practices the 'relational politics' of governance. I argue that it is because they enable us to keep ideas of emotion, experience and subjectivity in play that the idea of relational politics facilitates an understanding of these everyday practices as situated through, but not determined by the social relations of power. This refusal to collapse experience and power and to think instead in terms of 'relational politics' in between the individual and the social order is also crucial to understanding governance as an ethical practice, in the sense that it is always about the ongoing negotiations between ethics and politics. Thus, rather than mutually exclusive, politics and ethics are interdependent in governance.


The negative finding of the recent paper by Goldacre et al (2005) is an important addition to studies attempting to confirm or disprove the 'epidemiologic puzzle' (Jablensky & Lawrence, 2001), but the evidence remains ambiguous regarding the overall risk of cancer in people with schizophrenia. In three of five comparisons with reference populations conducted between 1992 and 2003 (see Grinshpoon et al, 2005), males with schizophrenia had a reduced risk of cancer. No reduction was found among females in four comparisons but decreased risk was reported in one of two comparisons of both males and females. Two recent studies (Dalton et al, 2005; Grinshpoon et al, 2005) mostly found reduced risk. When evaluating these results, it is important to recall that people with schizophrenia face many health and service hazards that may increase their risk for cancer (Grinshpoon et al, 2005). We therefore suggest that results in this area should not be stopped prematurely, especially since one study (Lichtermann et al, 2001), but not another (Dalton et al, 2004), found a reduced risk of cancer among first-degree relatives of patients with schizophrenia, an indication of a genetic factor (Park et al, 2004). The study by Goldacre et al (2005) had some limitations, as acknowledged by the authors. We wonder whether a diagnosis of schizophrenia at the time of the first admission may not constitute an additional limitation. Patients admitted with an early diagnosis of schizophrenia but who later received other psychiatric diagnoses might have diluted the risk (Carney et al, 2004), whereas others who did not have a diagnosis of schizophrenia on first admission but did on later contact might have been lost to the enquiry. We also wonder whether the decision to exclude some people from the reference population for selected cancers was sound. Admittedly, dietary factors may be imputed for those conditions selected for elimination as well as for cancer risk. We look forward to a repetition of the analysis after their inclusion.


Purpose To determine the differences in the corneal topography derived using a 16 mire videokerascope and a 2 mire autokeratometer and to examine whether the differences are clinically significant in the contact lens fitting context.


【Objective】 The citrus canker biocontrol bacterium Bacillus subtilis CQBS03 was labeled with green fluorescent protein gene to investigate the colonization of the bacterium on the citrus leaves.【Method】 The gene promoter p43 and green fluorescent protein(gfp) were connected by overlapping PCR,then the fusion gene p43-gfp was inserted into shuttle vector pHY300PLK and transferred into original strain CQBS03 by electroporation.The expression of GFP was visualized under the fluorescent microscope,and analized by SDS-PAGE.Antibacterial(Xcc01) activities of the engineering strain,dynamic analysis and stability were tested.And the re-colonization on the citrus was examined by the bacteria isolation and culture after leaf acupuncturing inoculation sprayed on leaves of citrus.【Result】 GFP was expressed efficiently and the protein about 29 kDa was detected by SDS-PAGE in engineering strain CQBS03-pHY43G.Heterogenous plasmid did not lead to significant adverse effects on the engineering strain.The stability of engineering strain was 55% after 30 generations.Antibacterial activities testing proved that there was no obvious difference(P0.01) between original strain CQBS03 and engineered strain.The population of strain CQBS03-pHY43G on leaves of citrus decreased sharply in the first 15 days after sprayed,then declined slowly after 15th day and remained constant at a lower level(1.73×103 cfu·g-1).【Conclusion】 The gene of gfp was inserted into Bacillus subtilis CQBS03 successfully and GFP-tagged strain was obtained,the colonizing patterns of bio-control bacterium were preliminarily elucidated.


The limitation of the harmful lead-containing solders used in the electronics
 and other industry applications change lead with another metals. Interfacial
 reactions between Sn-Zn alloys and Ni substrate after annealing at 400 and
 450°C were studied. Three intermetallic compounds Ni3Sn4, T1, γ-Ni5Zn21 and
 liquid Sn were observed in the Ni/Sn-Zn diffusion couples. Scanning electron
 microscope was used for the investigation of the microstructure. The
 microhardness measurement of the intermetallic layers was also performed.


In the Tennessee Valley Authority's (TVA's) nuclear and fossil plants, liquid-filled sensing lines are used extensively to transmit pressure from various process lines to electronic pressure transmitters. Because air can affect pressure transmission, TVA's engineering laboratory has been working to develop an instrument for detecting air in sensing lines. The presence of air can be detected by comparing measurements of the standing pressure wave frequencies for a sensing line with reference measurements taken when the line contains no air. Air in a sensing line shifts standing wave frequencies from their values with no air and can provide internal spring-like boundaries for surge oscillations. Standing pressure waves are elastic waves propagating through water in pipes. Characteristics to every piping system is an infinite number of natural, resonant frequencies at which standing waves can oscillate. Surge oscillation in sensing lines refers to harmonic oscillations of water columns acting as rigid masses. Both active and passive techniques have been tested. In either technique, air is indicated if standing wave frequencies are shifted relative to their values with no air or if a new surge oscillation frequency is detected. In both techniques, pressure fluctuations are measured with a hydrophone. Fourier transform techniques decompose themore » pressure signal into its various frequency components. The peaks in the frequency spectrum represent the standing wave and surge oscillation frequencies.« less


Possible hazards involved in the Mallinckrodt procedures for processing l%-enriched U are analyzed, and necessary precautions are specified. No danger is possible inhandling any amount of nominally l% U in the reduction of UF/sup 4/ to metal, cooling, or remelting. Critical amounts might conceivably be accumulated during the rolling to 3/4'' rod, in which case an''always safe'' amount is indicated. (B.J.H.) 2l92 A neutron burst from an untamped cylindrieal enriched U assembly occurred si ihe Pajarito Remote Control Laboratory ai 1800 hours on 18 April, 1952. The circumstances causing the burst and a description of the assembly involved are given. There was no personnel hazard. Normal operations could have been resumed on other assemblies within two or three hours after the burst. No evidence of damage to the enriched U was observed. Also reported are some results of computations and past-burst tests and a discussion of probable time behavior of power level during the burst. (auth)


Certainly one of the most thoroughly discussed and popular subjects in American sport history is the story of Jackie Robinson and the integration of organized baseball. Few topics elicit such a responsive chord or stir people's emotions more than the Robinson saga. It is a tale of courage and heroics, both on the part of Robinson and Branch Rickey, the "Mahatma" or "Deacon" of the national game. The details of Robinson's signing with the Brooklyn Dodgers can be vividly recounted even by those with a limited knowledge of baseball history. Perhaps no other episode in sport so conveniently fits our national perception of equality and fair play. While there has been a plethora of books written about the Robinson legend. no work covers the subject more thoroughly than Jules Tygiel's recent study Baseball's Great Experiment: Jackie Robinson and His Legacy. Combining exhaustive research with lucid writing, Tygiel's work makes significant advances over any of the books written previously about the Robinson legacy, including Murray Polner's Branch Rickey: A Biography, and Harvey Frommer's Rickey and Robinson: The Men Who Broke Baseball's Color Barrier. Maybe more than anything else, Tygiel's study forces us to confront some of the more somber truths and parables associated with the "national game." Despite arguments to the contrary, American baseball had not been a "melting pot" for diverse ethnic groups, nor had it eliminated the racial disparities that distinguished other phases of society. He makes it clear that organized baseball was characterized by a persistent white racism that made desegregation a painfully slow process. Closing its doors to blacks in the latter nineteenth century, organized baseball did not become desegregated again un-


Urbanization is an inevitable stage in China's market economy growth and development,the increasingly expanding city scale brings people more and more city problems.Therefore,how to improve the supply efficiency of city public goods under the current circumstance becomes a severe test for modern society.This paper studies the countermeasures of enterprises' effective supplying public city goods by analyzing the failure of Shiyan bus privatization on the basis of Western economic theory.


Driving behavior modeling (DBM) is widely used in the intelligent vehicle field to prevent accidents, which predicts actions that vehicles should take to optimize safe driving behaviors. According to some statistics, accidents easily happen at un-signalized intersections. Modeling driving behavior at such places is of great importance. However, current inverse reinforcement learning-based DBM methods fail to predict proper behaviors at the un-signalized intersections in the aspects of smoothness and stopping behavior by just using a single Markov decision process (MDP). We propose a novel sequential MDPs approach to model the driving behavior at the un-signalized intersections to solve the problems. Our approach decomposes the target behavior through the un-signalized intersections into three parts and models each decomposition's driving behaviors with appropriate time durations by a stopping-time-interval distribution through dynamic programming. Experiments on real driving data show that the proposed method achieved a better result and successfully improved the smoothness and stopping awareness of the planned driving path compared to the baselines.


We regret that in our CrossTalk article (Patel et al. 2012) we made an incorrect reference to a study. The correct references refer to work carried out within the same group and the substance of our argument remains unchanged. The paragraph in question (p. 3393, bottom of third column) should read: Another objection to RMT in disease is that changes in respiratory muscle function and performance correlate poorly. Importantly, Ramı́rez-Sarmiento et al. found that despite architectural adaptation of the intercostal inspiratory muscles, there was no improvement in 6MWD following RMT (Ramı́rez-Sarmiento et al. 2002). In another study, RMT increased inspiratory muscle endurance in COPD patients, without improving any functional performance measure (McKeon et al. 1986). Similarly, when investigating expiratory muscle training in COPD (Mota et al. 2007), 6MWD improved substantially even though classical airway physiology dictates that, in COPD, increasing expiratory force cannot increase expiratory flow. The incorrect reference is Orozco-Levi et al. (1999). The correct references are Mota et al. (2007) and Ramı́rez-Sarmiento et al. (2002).


Purpose
This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies.

Design/methodology/approach
This briefing is prepared by an independent writer who adds their own impartial comments and places the articles in context.

Findings
The positive impact of training can be enhanced if learners set appropriate goals at the outset. By opting to pursue a mastery goal, learners are likely to engage more with the deep learning strategies that are associated with a broader range of desirable outcomes for both learners and their organization.

Originality/value
The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.


A new method for measuring the imaginary part of refractive index structure parameter in the urban surface layer R. Yuan, T. Luo, J. Sun, Z. Zeng, and Y. Fu Key Laboratory of the Atmospheric Composition and Optical Radiation, CAS, School of Earth and Space Sciences, University of Science and Technology of China, Anhui, 230026, China School of Atmospheric Sciences, Nanjing University, Jiangsu, 210093, China


The invention relates to a method for generating image information of an image of an image sequence by using the image information of a first image. The object is to provide a method for generating image information of an image of an image sequence is available, so that a stroboscopic effect even at different speeds, movements of the image information is avoided and yet a clear presentation at low speeds of the image information is made possible, is achieved in that the number of intermediate frames is determined depending on the value of the first moving amount and a weighting factor is calculated for each intermediate image.


^ about the History.-A small rounded painless ^ irft size of a pea was noticed three ye ?roWth, the tumour. side of the face. Originally of^ slo\ g wainut, during rapidly increased in size to that the last five or six months. affected. No other member of the family situated over the On examination.?The tumour -u front of the left side of the face about half an ab0ve the lower lobule of the ear and about an in overlying skin border of the body of the mandible. tumour for an was telangiectatic and adherent 0 +um could be area half an inch across. No P rounded, fluctudiscovered. The tumour was smo > , jg over the ant and translucent. It was freely mova deep fascia.


Major accidents like Seveso, Flixborough, Piper Alpha, Bhopal, Chernobyl, Texas City, and the most recent Deepwater Horizon have painfully revealed failures that we can learn from. Human nature does not like to admit or reveal knowledge of problems and therefore people still remain the weakest link in the safety culture. Competency of every person working in the lifecycle of our process industry, is becoming the 'de facto standard' for those who want to keep their plant safe, productive and avoid very costly penalties and lawsuits. The author will draw on his 30+years experience to give the audience the top 10 most common failures and how they can be avoided.


How to accurately define the national interests of United States is a knotty problem.the United States' national interests is both abstract and specific,both popular and of class character.To define it requires an overall and systematic analysis.National interests of the United States that includes multi-level contents,is deeply affected by class,interest group,and ideology.The coincidence in the national interests of china and the U.S.A.The conflict between them,are the two root causes why the Sino-U.S relation advances tortuously.


An anaerobic-aerobic experimental equipment for wastewater biological treatment was developed. The equipment has the advantages of flexible and easy operation,low cost and practical usage. It can be used in the teaching and experiments for determination of technical parameters,cultivation of anaerobic and aerobic granules,denitrification and phosphorous removal. The equipment can help to train the scientific and innovative ability of both students and teachers.


The invention discloses a production of nanometer degradable high-obstruct packaging film and the method for preparation, specifically a degradable complex film prepared with degradable nanometer polymer as the obstruct material. Said complex film has a layer structure containing at least two outer layers and one interlayer, at least one layer among which is the obstruct layer, the obstruct layerbeing made up of degradable nanometer polymer, and others being made up of degradable polyolefin or polyolefin. The high-obstruct degradable film is transparent and has obstruct to oxygen and aqueousvapor. Modified by nanometer inorganic material, it can prepare 3- 7 layer film, which has high obstruct and makes the article packaged have long shelf retention period and can be degraded after one or two years, and has the same effect with dry complex and coextrusion complex film.


to the editor: We read with interest the comments from Sacco et al. ([4][1]) on our manuscript. We feel clarification on their points is necessary to reflect the entirety of the literature on the subject. Although there may be some early effects on motor-related issues in diabetes (DM), based on


geal cancer was admitted to our hospital due to tarry stools. He had difficulty with oral intake due to stricture caused by the esophageal cancer and received his nutrition via gastrostomy. Laboratory findings revealed severe anemia, and gastrointestinal bleeding was therefore suspected. The stricture caused by the esophageal cancer made it impossible to pass the gastrointestinal endoscope. As a last resort, therefore, endoscopy via the gastrostomy was attempted in order to identify and treat the source of bleeding. We were able to pass the gastrointestinal scope (Olympus XP260N; Olympus Corp., Tokyo, Japan), via the gastrostomy port into the stomach (●" Fig. 1). Oozing of blood was observed from a lesion in the body of the stomach (●" Fig. 2). Endoscopic hemostasis was achieved using argon plasma coagulation (●" Fig. 3) after changing the scope to an Olympus Q260. Computed tomographic examination revealed that the bleeding was caused by invasion of the stomach by a cancerous lymph node (No. 3) (●" Fig. 4). Since it was first described in 1980, percutaneous endoscopic gastrostomy tube placement has been widely used for longterm nutritional support in patients with severe neurological impairment [1]. However, to date, endoscopic hemostasis through a gastrostomy has scarcely been reported. In our present case, there were no complications associated with hemostasis achieved endoscopically via gastrostomy. It is therefore suggested that in patients with a gastrostomy, the gastrostomy tube may serve as a valid alternative approach for endoscopy. Competing interests: None


A stigmatized property, or a psychologically impacted property, is a real estate property that suffers from an undesirable past event, such as a suicide or homicide, that affects the present property value. This paper provides the first empirical evidence of the existence of the negative externality of stigmatized property, based on data on rental housing and stigmatizing events recorded in Tokyo, Japan. Although the estimation result using the standard hedonic approach ensures the presence of the externality, it does not represent the degree of the implicit externality under complete information, in which prospective renters are fully informed. This is because property owners strategically assign offered rental prices by assuming that prospective renters face incomplete information about the surrounding stigmatized properties. Therefore, we examine the implications underlying the estimated hedonic functions by imposing several valid assumptions.


MH61 is a monoclonal antibody that reacts to acrosome reacted human sperm but not to fresh ejaculated sperm.1) When the sperm were mixed with the antibody-coated, paramagnetic polystyrene beads, only the acrosome reacted sperm bound to the beads. The close relationship of the ability of sperm to bind to the beads and to fuse with zona free hamster eggs was demonstrated.2) The molecular weight of the antigen was estimated as 43kD by SDS-PAGE and immunoblotting.1) However, the amino acid sequence of the antigen remained unknown. In the present report, the antigen was blotted on PVDF paper and analyzed by an automated gas phase amino acid sequencer .


A layered melt‐textured YBa2Cu3O7−x superconductor has been prepared consisting of alternate fully oxygenated and oxygen deficient bands stacked parallel to a‐b planes. An anomalous decrease of Jcc(H∥ab) with field is observed at high temperatures. We show that this behavior is a signature of a field induced decoupling of the strong superconducting bands, and provides evidence of a decrease of vortex pinning energy in oxygen deficient regions of melt‐textured YBa2Cu3O7−x. A large downwards shift of the irreversibility line results as a consequence of the substantially smaller area where a critical state sets in. When vortices are parallel to the c‐axis Jcab(H∥c) decreases due to the smaller condensation energy of the oxygen deficient bands.


Edge detection is a fundamental tool in image processing and computer vision, particularly in the areas of feature detection and extraction. Among various edge detection methods, Otsu method is one of the best optimal thresholding methods for general real world images with regard to uniformity and shape measures. In this paper, a multispectral thresholding algorithm using Otsu method is proposed to detect the edges in multispectral images. Natural, art and simulated images are considered for testing. Since the edges are well known in the simulated images, they are considered for performance evaluation. The results of proposed method, Edge Detection using MultiSpectral Thresholding (EDMST), are compared against the results of Canny Otsu, Improved Otsu, Median based Otsu and Improved Gray Image Otsu edge detection algorithms based on the human visual system, the number of edges and the number of pixels. The experimental results show that the proposed method achieves better performance and hence applied on Satellite images.


Magneto-optical microscopy decreasing temperature spectrum system, comprising: a laser; a refrigeration unit controls the temperature of the sample; rt superconducting magnet having a central hole providing a magnetic field for the magneto-optical Dewar spectrum; a laser incident optical path to the laser the output of the laser is introduced and focused onto the sample surface in the cold head to excite the fluorescence spectrum of the sample; a sample light path monitor monitoring the laser focus position and the focus to the specific case of the sample through the first beam splitter and the microscope objective; a signal collecting light path to the fluorescent signal is transmitted to a spectrometer for spectroscopic measurements through the multimode fiber; one optical fiber monitoring the optical path to observe the specific position of the fluorescent signal and the reflected laser signal, ensuring that the sample fluorescence signal is effectively the fiber collecting multimode; a spectrometer and a corresponding detector , located at one end of the multimode optical fiber, dispersion and fluorescence signal measured for the sample.


Anne E. Polivka is a research economist in the Office of Employment Research and Program Development, Bureau of Labor Statistics. of continuing in their jobs. Under this definition, there were approximately 2.7 million contingent workers in February 1995. The second estimate of contingent workers added self-employed workers and independent contractors who expected their employment to last for an additional year or less and who had been self-employed or an independent contractor for 1 year or less. It also changed the measure of actual and expected job tenure for contract workers and temporary help workers from tenure with these employment intermediaries to tenure in their current assignment. Under these criteria, 3.4 million workers were classified as contingent in February 1995. The third estimate of contingency expanded the second estimate by removing the 1-year requirement on actual and expected tenure for wage and salary workers. (The tenure constraint could not be removed for self-employed workers and independent contractors because they were asked a different set of questions.) Essentially, under estimate 3, contingent workers were defined as workers who did not expect their jobs to last, except those who, for personal reasons, expected to leave jobs that they would otherwise be able to retain. Under this broadest estimate, 6 million workers were classified as contingent. In this article, the characteristics of continT o some, the terms "contingent work" and "bad jobs" are synonymous, although that was not necessarily what was intended when the phrase was originally coined. To examine how closely these two notions may be linked, it is necessary to analyze specific attributes of contingent jobs, along with the personal characteristics of those who fill them. This article profiles contingent workers using data collected through a special supplement to the February 1995 Current Population Survey (CPS). This supplement provides the first comprehensive measurement of contingent workers using carefully constructed definitions. The underlying concept that was operationalized in the supplement defines contingent workers as individuals who do not have an explicit or implicit contract for ongoing employment. The introductory article in this issue (pages 3–9) discusses three estimates of the number of contingent workers constructed from the February 1995 CPS supplement data. The first estimate was restricted to wage and salary workers who expected their jobs to last for an additional year or less and who had worked at their jobs for 1 year or less. Individuals who did not expect to continue in their jobs for personal reasons, such as retirement or returning to school, were not considered contingent if they would have had the option A profile of contingent workers


We present MINESweeper, a tool to measure stellar parameters by jointly fitting observed spectra and broadband photometry to model isochrones and spectral libraries. This approach enables the measurement of spectrophotometric distances, in addition to stellar parameters such as Teff, logg, [Fe/H], [α/Fe], and radial velocity. MINESweeper employs a Bayesian framework and can easily incorporate a variety of priors, including Gaia parallaxes. Mock data are fit in order to demonstrate how the precision of derived parameters depends on evolutionary phase and SNR. We then fit a selection of data in order to validate the model outputs. Fits to the benchmark stars Procyon, Arcturus, and the Sun result in derived stellar parameters that are in excellent agreement with the literature, except for the surface gravity of Arcturus, where our value (1.35) is notably lower than the literature (1.66). We then fit combined spectra and photometry of stars in the open and globular clusters M92, M13, M3, M107, M71, and M67. Derived distances, [Fe/H], [α/Fe], and logg−Teff relations are in overall good agreement with literature values, although there are trends between metallicity and logg within clusters that point to systematic uncertainties at the ≈ 0.1 dex level. Finally, we fit a large sample of stars from the H3 Spectroscopic Survey in which high quality Gaia parallaxes are also available. These stars are fit without the Gaia parallaxes so that the geometric parallaxes can serve as an independent test of the spectrophotometric distances. Comparison between the two reveals excellent agreement within their formal uncertainties after accounting for the Gaia zero point uncertainties.


The Histograms of Oriented Gradient features are common object detection feature descriptors in computer vision and image processing. The features are widely used in the field of pedestrian detection, but the calculation speed is slow, and it is not fit for the situation of high real-time demand. This paper introduces the original HOG feature extraction algorithm, and simplifies some time consuming steps for the hardware implementation, namely gradient calculation in the HOG feature extraction and histogram calculation to meet the requirements for hardware implementation. This paper also particularly analyzed the size of gradient used in different simplified methods, shows the simulation results in Matlab2014a, and compared the calculation results and computing time of different methods, proving the correctness and efficiency of the simplified method, which lays a theoretical basis for the follow-up of hardware implementation.


abstract:This article analyzes how biases in Shaw's media environment are reflected in his experiences and representations of the First World War. After turning to contemporary media theory to assess the ways in which war mediates the legibility of one's surroundings, this article discusses Shaw's critique of war delirium in "Common Sense about the War." After examining excerpts from "Joy Riding at the Front" and the preface of Heartbreak House—which diverge in interesting ways from "Common Sense"—this article concludes by offering some speculative insights into what Shaw's war ambivalence contributes to new media theory.


The utility model discloses a multilayer grading ring structure which includes a multilayer metal ring body. A discharge ring is arranged between adjacent metal ring bodies; the discharge ring circumferentially is uniformly provided by a metal ring with multiple fractures; and each discharge ring is respectively connected with an upper metal ring body and a lower metal ring body through a metal guide rod, wherein the upper and lower metal ring bodies are adjacent. The multilayer grading ring structure is simple structure; in the multilayer grading metal ring body, the discharge ring is arranged between the adjacent metal ring bodies; the discharge ring is used to discharge through multiple fractures, so that the discharge ability of the fractures is improved; and the better voltage equalizing effect is realized.


Arc grounding over-voltage is one of the worst over-voltages in the neutral isolated system. It is an important factor to be considered when selecting neutral ground mode. At present, system simulation is the main method for the study of the arc grounding over-voltage. Arc extinguish and re-ignition is simulated by controlling the switch on or off. However, the switch opening or closing need to be controlled by the manually preset timer, according to the principle that arc re-ignites for every other power frequency cycle or half power frequency cycle. In fact, arc re-ignition may not occur at the maximum recovery voltage of the faulted phase because of the statistical property of arc occurring. For this reason, the simulation model based on the fixed timer controlled switch is not accurate. In addition, the timer for the switch opening or closing is needed to be reset every time when the system operating mode changes. This process is very complex so timer controlled model is difficult to apply in practice. In the light of the above, a new simulation model is proposed in this paper, which is based on a comprehensive study of the mechanism of the generation of arc grounding voltage. Transient analysis of control system using the TACS and MODELS modules of EMTP is employed to study and design the control section of the switch. The control program is compiled by the special language of MODELS module. There is no need to set the opening and closing time of the switch. This simulation model offers flexible operation and is more close to the actual situation. Desirable results are achieved when applied to study the arc grounding over-voltage in 10kV neutral isolated system. Simulation results from EMTP verify the correctness of this model, which also have a great potential for practical applications.


A differentiation method of embryonic stem cell by using the porous membrane is provided to maximize the differentiation efficiency and improve the yield of differentiated cell by efficiently delivering the differentiation factor secreted from the stromal cell through pores. The embryonic stem cell is differentiated by co-culturing the embryonic stem cell or the embryoid derived from the embryonic stem cell in the culture medium for differentiation containing the porous membrane in which the feeder cells are adhered in the bottom, wherein the embryonic stem cell or embryoid is co-cultured on the porous membrane.


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This investigation concerned the population dynamics and the possible control of Tribolium confusum Jacquelin duVal and T. castaneum (Herbst) subjected to chronic irradiation. At 3 dose levels of 60Co gamma radiation (24, 49, and 170 R per day) 5 replicate populations of single species (20 pairs in each) and of mixed species (10 pairs of each species) were established in 5 g of food in lucite test tubes. Larvae, pupae, and adults were counted monthly and along with eggs were transferred to new food. Culture conditions were 25 and 32°C in 70–75% relative humidity.

In general, at 25°C the single-species reproductive performance, measured as the number of larvae and adults, was impaired by exposure to radiation. Poorest performance appeared at 170 R per day; whereas, 24 and 49 R per day resulted in reduced, but comparable productivity. Larvae were more radiation-sensitive than adults. Numbers of adults reached zero more slowly than larvae at 170 R per day, indicating no adult replacement. Results were accentuated at 32°C.

Responses to radiation of mixed- and single-species populations were comparable at 25°C. There was greater survival of larvae and adults in mixed-species populations at 32°C than at 25°C.

Data from this experiment showed that 170 R per day dose rate was sufficient to stop larval development; but 49 R per day was not enough to eliminate flour beetle populations. The radiation effects on population performance were attributed to induced genetic aberrations rather than to physiological impairment. The feasibility of implanting radiation sources in a grain storage facility to control insects is discussed.


In a backbone network (𝑈􀯡 ≥ 220 𝑘𝑣), when the high-voltage lines are loaded with power less than natural power, we have excess reactive power. Supplying this power into the lower-voltage networks (𝑈􀯡 ≤ 110 𝑘𝑣) would be technically and economically unfeasible and requires compensation on site. In the article, in accordance with the electricity quality criterion, and taking into account the principle of a systemic approach, and using the self- and mutually reactive impedances of the network junction points, a mathematical model for selecting a compensating device in a backbone network is adopted. The quality criterion of electricity involves enforcement of requirements for the operating voltages in the junction points of a backbone network. According to the obtained mathematical model, in the junction points nodes where the operating voltages exceed their permitted values, there will be installed the compensating devices for receiving excess reactive power. However if any junction point has a high reactive load and the voltage, in this context, is below its permitted value, then, according to a model, there is a need for installing the source of reactive power in this junction point. Herewith, according to economic criterion, the model envisages the optimal redistribution of mentioned source of reactive power between the junction points of a distribution network connected to backbone network junction point.


High performance liquid chromatography (HPLC)-atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) was applied to analyze the triterpenoids in extracts of Ganoderma lucidum. The extraction conditions are: Hypersil C4 (4.6 mm × 150 mm) column with gradient elution with acetonitrile and water (2.0% acetic acid) as mobile phase, flow-rate 0.8 ml/min, and room temperature about 25 ℃. The detection wavelength is 253 nm and the UV spectra of peaks are obtainedwith a photodiode array detector (DAD). On-line APCI-MS in positive and negative mode was used to get the mass spectrum of the analyte. Thirty-two components of Ganoderma lucidum are primarily identified by comparison of the UV spectra and mass spectrum according to published literatures.


Based on the precipitation samples collected in Minxian in the western Loess Plateau from 2019 to 2021, this study analyzes the influence of moisture sources on precipitation isotopes. Through the specific humidity correction of the backward trajectory, it is found that Xinjiang and the middle and lower reaches of the Yangtze River may be the main moisture sources. Through cluster analysis of backward trajectories, it is found that in the summer half-year, the water vapor from the east and northeast leads to the precipitation with a depleted isotope ratio, while the water vapor from the south and northwest leads to the precipitation with an enriched isotope ratio; in the winter half, water vapor from the east leads to precipitation with enriched isotope ratios, while water vapor from the northwest and northeast leads to precipitation with depleted isotope ratios. In addition, the precipitation isotope values showed a tendency to deplete with the duration of water vapor transport in the summer half-year, but this tendency was not obvious in the winter half-year. The relationship between precipitation isotopes and water vapor transport height showed a positive correlation in both the winter half-year and summer half-year. Using the Potential Source Contribution Factor analysis methods and the backward trajectory after the specific humidity revision, it was found that the potential evaporation source areas in the summer half-year are larger in extent, mainly distributed in the eastern and southern regions of the sampling site, and the contribution of local recycled vapor to precipitation is 32.17%; while the potential evaporation source areas in the winter half-year are smaller in extent, they are only distributed in the southern region of the sampling site, and the contribution of local recycled vapor to precipitation is 24.66%.


The performance of multihop detect‐and‐forward relaying system is analyzed over fluctuating two‐ray fading channels for 28 GHz millimeter wave communications. Exact closed‐form expressions for outage probability and average symbol error rate of various modulation schemes over nonidentically distributed fluctuating two‐ray fading channels have been obtained. The derived expressions are given in terms of the Lauricella hypergeometric functions Φ2(n)(·) and FD(n)(·) . Moreover, the derived expressions also accommodate several others reported results in the literature for two‐wave diffuse power, Rician, Rician shadowed, Nakagami‐m, and Hoyt fading channels. Asymptotic outage probability and average symbol error rate expressions are also derived, which provide useful insights on the factors governing the performance of the considered system. The numerical results have been verified with Monte‐Carlo simulation results.


This thesis deals with an optimisation of chromatographic conditions for the determination of the selected stilbenes and catechins using RP-HPLC coupled with electrochemical CoulArray detection. The optimized method is applied to the analysis of the extracts prepared from roots of Polygonum cuspidatum.


of this version of 1698 that has now appeared in the Cass Library of Science Classics. The editorial intervention is limited to a five-line Publishers' Note, serving to identify the text, a list of known editions and translations, and an index prepared by the general editor of the series, Dr. L. L. Laudan, late of University College London. The needs of students requiring a plain English text of this little classic will be admirably met; but an introduction and a few explanatory notes would have enhanced its usefulness. In the Note the possessive of Huygens is misspelt HuygerCs.


Regional early warning is an important means for improving the consciousness of geohazard prevention and reduction and effectively mitigating the loss caused by geohazards.In the early-warning method of explicit statistics,the effect of coupling of multiple factors such as geo-environmental change and precipitation is considered,thus overcoming the limitation of the single critical rainfall criterion.Based on the explicit statistic theory on geohazard early warning,apphed studies have been carried out in the southeast of China.Twelve geo- environmental factors such as rock and soil types and topographic relief are selected to analyze the relationship between the distribution of geohazards and geo-environmental factors by using the determinacy coefficient function(CF),and the geohazard potentiality parameter is selected as an index of the geo-environment and quantitative calculation is performed.The very day rainfall and previous cumulative rainfall in one rain process are selected as an index of rainfall excitation conditions.Finally,the multi-regression analysis is used to analyze the relationships of the geo-environmental factor,rain excitation conditions and geohazards.Then an explicit statistic early-warning model for geohazards is constructed.Take for example the early warning during the land striking of the typhoon"Pearl"on May 18,2006,the authors check the forecasting model and prove that the principle and model of explicit statistics early warning are feasible and practicable.


Epidermal growth factor receptor (EGFR) activating mutations occur in approximately 50% of East Asian patients with non‐small‐cell lung cancer (NSCLC) and confer sensitivity to tyrosine kinase inhibitors (TKIs). ASP8273 is an irreversible EGFR‐TKI, given orally, that inhibits EGFR activating mutations and has shown clinical activity in patients with EGFR mutation‐positive NSCLC. Epidermal growth factor receptor‐TKI‐naïve Japanese adult patients (≥20 years) with NSCLC harboring EGFR mutations were enrolled in this open‐label, single‐arm, phase II study (ClinicalTrials.gov identifier NCT02500927). Patients received ASP8273 300 mg once daily until discontinuation criteria were met. The primary end‐point was to determine the safety of ASP8273 300 mg; the secondary end‐point was antitumor activity defined by RECIST version 1.1. Thirty‐one patients (12 men and 19 women; median age, 64 years [range, 31‐82 years]) with EGFR mutation‐positive NSCLC were enrolled; as of 23 February 2016, 25 patients (81%) were still on study. Of the 31 patients, 27 (87%) had an exon 19 deletion (n = 13, 42%) or an L858R (n = 14, 45%) EGFR activating mutation, and two (7%) had an L861Q mutation. Five patients (16%) had other EGFR activating mutations, two had an activating mutation and the T790M resistance mutation. The most commonly reported treatment‐emergent adverse event was diarrhea (n = 24, 77%). All patients had at least one post‐baseline scan; one patient (3%) achieved a confirmed complete response, 13 (42%) had a confirmed partial response, and 15 (48%) had confirmed stable disease (disease control rate, 94% [n = 29/31]) per investigator assessment. Once‐daily ASP8273 at 300 mg was generally well tolerated and showed antitumor activity in TKI‐naïve Japanese patients with EGFR mutation‐positive NSCLC.