This study aimed at assessing the effect of cultivation time, local substrates and their weight on urban smallholder oyster mushroom production in Zimbabwe. The study was carried out in a low cost urban  mushroom growing house and laid out in a randomized complete block design with each treatment replicated four times. Substrate type was highly significant (p<0.01) on  days to fruiting, mean number of mushroom, mean mushroom weight and biological efficiency. Evaluation of different substrates for cultivation of oyster  mushroom revealed that among the different substrates, wheat straw was superior which recorded minimum days to fruiting (16.62 days), maximum number of mushroom heads (106.25), maximum average yield per 3 months (4826.63g) and highest biological efficiency of 66.88%. Wheat straw accelerated the mushroom growing process having the lowest duration of days to fruiting. The mycelia completed colonization, primordium initiation and fruiting body formation were found within 16.62±0.69,  22.75±0.69, 26.88±0.69 and 31.00±0.69 days for wheat straw, hay, maize stalk and groundnut hulls, respectively. Wheat straw was found to have the highest biological efficiency (66.88±4.59) followed by hay (41.88±4.59), groundnut hull (40.00±4.59) and maize stalk (39.88±4.59). However, the biological efficiency decreased  with increase in substrate weight per bag, and substrate weight did not influence the days to fruiting.


An experiment was conducted to evaluate some plant origin commercial biopesticides against red spider mite in tea under both in the Entomology Laboratory and main farm of Bangladesh Tea Research Institute (BTRI), Srimangal, Moulvibazar during the period from March 2013 to December 2014. Bio-Cawach ( Pongamia pinnata ), Karanza ( Azadirachta indica + Pongamia pinnata ), Miticon (Various herbs, alkaloids and salt of fatty acids), Neemakar (Neem, Karanja & Tulsi), Rescue ( Vitex negundu + Clerodendron infortunatum ) and Torpedo ( Sophora alopecuroides + Stemona sessilifolia ) were considered as treatments and dosages were @ 0.8 ml, 1.0 ml, 1.0 ml, 1.0 ml, 0.5 ml and 0.5 ml, respectively. Data were collected at 24 HAT, 48HAT, 72HAT (Hours after Treatment) in the laboratory and at weekly interval in field condition. Results indicated that all the biopesticides showed the toxic effect on red spider mite in tea and significantly reduced mite population both in laboratory and field conditions. In laboratory condition, Miticon showed the highest (93.28%) toxic effect at 72HAT followed by Karanza (92.55%) against red spider mite where as Bio-Cawach, Neemakar, Rescue and Torpedo exhibited pronounced acaricidal action (89.78%~91.67%) at 72HAT. Similar trend of toxicity was found at 24HAT & 48HAT. The mortality was in a linear trend i.e. increasing with increasing of time. From the field evaluation, it was found that the highest (81.34%) reduction in mite population was observed in Miticon treated plot followed by Rescue treated plot (81.01%). The lowest (74.07%) reduction in mite population was observed in Bio-Cawach treated plot. The order of toxicity of the six plant origin commercial biopesticides on adult red spider mite in both laboratory and field condition was: Miticon>Rescue>Neemakar>Karanza>Torpedo>Bio-Cawach. Application of the tested biopesticides did not affect the natural predators such as Stethorus gilvifrons and Oxyopes sp. Tea samples made from biopesticide-treated shoots were found taint free when subjected to organoleptic evaluation. These eco-friendly low cost plant products can therefore be incorporated in the strategy of integrated pest management (IPM) to reduce the load of chemical pesticides in tea.


Hydraulic pipeline transportation of a piped vehicle is a new mode of transportation with energy-saving potential and environmental protection. In order to analyze the turbulent characteristics of the flow around the piped vehicle, a large eddy simulation (LES) method was adopted to simulate the hydraulic characteristics and vortex characteristics of the flow at a Reynolds number of Re = 140,467 with diameter-to-length ratios of 0.4, 0.5, 0.6, and 0.7. The results showed that the main factor that affected the gap flow velocity, the backflow area length, and the turbulence intensity was the cylinder diameter in the diameter-to-length ratio of the piped vehicle. The backflow area lengths for piped vehicles with different diameter-to-length ratios were all less than 1 D, and the axial disturbance distances were about 7.5 D. In addition, a variety of vortex structures existed in the gap flow and the rear flow areas. At the beginning of vortex development, ring vortices were generated at the front and rear ends of the cylinder body. Subsequently, the front ring vortex fell off along the cylinder body and evolved into hairpin vortices. At the same time, a reflux vortex was formed after the rear ring vortex broke away from the cylinder body, and wake vortices were generated behind the rear supports. Finally, some worm vortices were dispersed from the wake vortices. These results can further improve the theoretical system for the hydraulic pipeline transportation of piped vehicles and can provide a theoretical basis for industrial application.


The paper presents the features of the development of endothelial dysfunction in workers under lead exposure. The results of laboratory manifestations of endothelial dysfunction have been demonstrated on the base of the study of parameters of vascular molecule of adhesion vCaM-1, soluble molecule of intercellular adhesion Sіcam-1, endothelin-1 in the blood of workers who professionally contact with lead. The features of formation of endothelial dysfunction, depending on the content of lead in the blood were identified. The thresholds for the studied parameters of endothelial dysfunction which are associated with high risk of atherosclerosis in this category of workers were determined.


To study on the spatial variability of soil properties for the understanding of the differences in soil is important. Using ordinary Kriging and sequential Gauss simulation methods, we calculated and simulated the spatial distribution of soil total nitrogen and available phosphorus in the Longtan watershed of the Dabieshan Mountain. The results showed that the spatial variability of soil total nitrogen and available phosphorus were moderate with strong spatial autocorrelation. Semivariogram was of exponential model, with total nitrogen variable range of 333 m and phosphorus variable range of 474 m. Total nitrogen content was mainly 1.2-1.6 g kg-1, accounting for 34.96% of the total area, higher in the central and southern watershed. Available phosphorus content was mainly 60-100 mg kg-1, accounting for 42.17% of the total area, comparatively higher in the northwestern and southern watershed. The 1 000 sequential Gauss simulation showed that the soil total nitrogen and available phosphorus obtained by ordinary Kriging spatial distributions was smooth, while the result from sequential Gauss simulation was relatively discrete with great volatility. The critical probability value of 0.50 can meet the conditional simulation requirement. Stochastic simulation can describe the spatial distribution of soil properties uncertainty and provide a powerful tool for spatial structure of regional soil attributes.


Abstract : We report significant findings in three distinct areas of investigation: I. Uncertainty Quantification: Propagation and Stochastic Systems; II. Numerical Interface Methods; III. Non-smooth Variational Problems and Inverse Methods. Topics investigated include effects of different types of delays on the dynamics of stochastic systems; the performance of different methods for quantifying parameter uncertainty due to measurement error: asymptotic theory, bootstrapping, and Bayesian estimation; very general optimal design problem for the selection of best states to observe and optimal sampling times and locations (i.e., selections of what, when, and where to observe) for parameter estimation or inverse problems involving complex nonlinear partial differential equation, ordinary differential equation and/or delay differential equation systems; the identification of thermal degradation using probabilistic models in reflectance spectroscopy; optimal control based ideas (bang-bang system stimulation) for enhancing the information content and minimizing related estimated parameter uncertainty in dynamic data sets; high order compact finite difference schemes for Helmholtz equations with discontinuous wave numbers across interfaces; numerical sensitivity analysis with respect to the Reynolds number for the flow past obstacle problems; efficient, 3D fast Poisson solver for bio-molecular simulations; adaptive Cartesian method for Immersed Boundary (IB) and Immersed Interface Method (IIM) for elliptic interface problems and for two phase flows with moving interfaces; efficient numerical methods for non-smooth variational problems; staggered-grid based ed central finite difference scheme is developed for Stokes and Navier-Stokes equations and Maxwell equations; probing methods for inverse medium problems, including electric impedance tomography and the diffusive optical tomography.


ABSTRACT Research question: Sports volunteering can signal qualifications and distinguish applicants in the job application process. The purpose of this study was to identify and quantify the signaling effect of sports volunteering activities in a curriculum vitae (CV) to potential employers. Few previous studies have explicitly examined the labor market outcomes of sports volunteering and its effects on the job application process. Research methods: To examine the signaling effect of volunteering activities in CVs, 474 people involved in hiring processes (i.e. hiring managers) participated in this study. Both sports volunteering activities and internship experience were examined as different experimental conditions. Moreover, the subjects were randomly split into different experimental groups and asked to rate the skills and qualifications of a female applicant, and whether they would invite the applicant to an interview and what would be the salary offered upon hiring her for three different jobs. Results and findings: Sports volunteering had a positive effect on hiring managers' perception of the qualifications of the applicant for all three jobs but affected the outcome of the application differently concerning the likelihood of inviting the applicant to a job interview or the salary that would be offered, but only if the job was closely related to the volunteering activity. The effects of internship experience were marginal. Implications: Sports volunteering activities can be used to signal social skills in the context of job applications. This study provides evidence that, in some cases, there is a causal relationship between volunteering and higher wages.


Football Club Barcelona Museum Camp Nou, Barcelona Access: Taxi, official bus tour and "Palau Reial" stop (Barcelona Metro Line 3) and "Collblanc" stop (Barcelona Metro Line 5) Website: www.fcbarcelong.cat/web/english/club/club_avui/ territori_barcalfabmuseu/index.html. Hours of Operation: Monday to Saturday, 10:00 a.m. to 6:00 p.m. and Sunday morning (closed all major/national holidays). Admission: €22.00; €17 (under 13). Free admission to children under five.


The article examines the current state of modelling correction classes in socio-cultural educational environment of integrated education of children with normal development and disabilities in comprehensive schools. New groups of correction classes models are presented for consideration and implementation.


Boost-type switch-mode rectifiers (SMR) commonly use a resistor or a magnetic current sensor to measure the instantaneous input or inductor current that is used as the feedback to the current controller. In this paper a novel current sensorless scheme is described that computes the inductor current from the measured inductor voltage in a single-phase boost-type SMR using an adaptive low pass filter. This calculation requires an estimate of the inductance and the equivalent series resistance of the inductor coil. Both these parameters are dependent on operating conditions and hence have to be updated continuously. This is done using an adaptive model of the inductor that computes these parameters of the inductor once in every half cycle of the input current. The adaptation scheme is robust against parameter variations. Simulation and experimental results confirm the effectiveness of the proposed technique which provides comparable performance to standard measured feedback current scheme both under steady-state and transient conditions.


This article presents a deep learning (DL) model integrated automated and secure garbage management scheme using unmanned any vehicle (UxV) to minimize the human effort in terms of the traditional garbage management system. Different kinds of UxV (unmanned aerial vehicles, automated guided vehicles, unmanned surface vehicles, unmanned underwater vehicles, etc.) are utilized to establish an automated garbage management scheme to collect and place the garbage both from the ground and sea surfaces. However, due to the limited battery capacity and inadequate resources of different UxV, a lightweight DL model is developed to detect the garbage successfully with a higher accuracy rate. The proposed lightweight DL model uses two activation functions named MISH and rectified linear unit to enhance the feature extraction and detect the garbage. Moreover, a multiaccess edge computing (MEC) server is allocated in the proposed scheme to improve the Quality of Service (QoS) (i.e., reduce latency and improve security). Furthermore, a blockchain-based secure hazardous garbage (e.g., infectious, toxic, or radioactive materials) tracking technique is concluded in this scheme to identify the individual and reduce the potential harm to the environment. Experimental results demonstrate that the UxV can successfully detect the garbage using the proposed lightweight DL model within a minimum time frame and the obtained accuracy is higher than the other existing DL models. Besides, QoS has been investigated to verify the efficacy of the proposed scheme. Finally, a private blockchain network is established to demonstrate the performance of the proposed hazardous garbage tracking technique.


The monitoring of grass production is not only an important measurement index for researching the spatial dynamic patterns of grassland resources,but also an important basis for the optimal use of grassland resources and for monitoring the balance between grassland forage supply and livestock demand.A total of 371 grassland investigation and remote sensing(RS) data of MODIS-NDVI from 2005-2009 were used to establish a relational model between grass production and RS data.The temporal and spatial distributions of grass production in Xilinguole,Inner Mongolia were simulated and analyzed.The main conclusions are as follows:(1) Each model equation had good relativity,among which the power function model was the most appropriate for the calculation of grass production.Through reservation quadrat data,the accuracy of the production estimation model was 78%.It was feasible for the power function model to be applied for RS monitoring.(2) Grass production in the Xilinguole grassland amounted to an average of 34550000 tons over five years,equivalent to 11120000 tons of hay,and the dry weight per unit area was 567.23 kg/hm2.The spatial distribution of grass production showed a "high east and low west" pattern.(3) An obvious fluctuation in grass production appeared during 2005-2009.The range of hay was 8000000-14000000 tons,and the coefficient of variation was 20.42%.(4) There were greater differences in the single grass yield and the annual variation of different grass types.There were lower grass yields and greater annual variation in desert grassland,and higher grass yields and relatively lesser annual variation in meadow grassland.The spatial and temporal variation of grass yields also had the close relation with the major climate factors(precipitation,temperature,etc.),especially with the influence of precipitation.This research provides a reference for the protection and utilization of grassland resources.


Prenatal diagnosis of isolated cleft soft palate by ultrasound imaging is rare1,2. Diagnosis of cleft soft palate has been reported in a fetus with Fryn's syndrome using three-dimensional (3D) thick-slice sonography and magnetic resonance imaging3. Recently, novel 3D ultrasound techniques have been described to assess the normal fetal posterior palate4–7. In particular, anterior axial 3D reconstruction rendering of the fetal palate can provide important diagnostic information about the integrity of the secondary palate6. We report the specific prenatal sonographic features of a case of isolated cleft soft palate that was retrospectively diagnosed on postnatal analysis of stored ultrasound volumes. A 38-year-old woman (gravida 4, para 1) was referred for a second-trimester anomaly scan at the Ospedale Microcitemico, Cagliari, Italy, because she, her father and her first child were all born with an isolated cleft soft palate. First-trimester screening, with nuchal translucency measurement, was normal and the fetal karyotype, obtained by chorionic villus sampling, was 46,XY. An anomaly scan was performed at 21 + 5 weeks, with particular attention paid to the fetal facial and cranial anatomy, using two-dimensional (2D) ultrasound examination (Voluson GE 730 Expert, GE Medical Systems, Kretz, Zipf, Austria) integrated with color Doppler imaging8. It showed normal fetal biometry, anatomy and amniotic fluid volume. Despite the high risk of cleft soft palate in the fetus, no abnormalities were detected by real-time survey. 3D/four-dimensional (4D) transabdominal ultrasound imaging was then Figure 1 Axial view of the palate of a fetus postnatally diagnosed with cleft soft palate. The image was obtained by offline analysis of the three-dimensional volume and using volume contrast imaging. The arrow indicates the incisure visible in the posterior margin of the soft palate.


in book of abstracts of international conference in English 15. Hódsági, M., Gelencsér, T., Gergely, S., Hevér, A., Jámbor, A. & Salgó, A. (2010) Some novel basic and applied researches of resistant starches. 9 th European Young Cereal Scientists & Technologists Workshop, Budapest, Hungary, 25.-27.05.2010, p. 41. Abstract in book of abstracts of international conference in English not used in the dissertationin book of abstracts of international conference in English not used in the dissertation 16. Hódsági, M., Gelencsér, T., Gergely, S. & Salgó, A. (2009) Investigations of the effects of different storage conditions on native and resistant starches. 8 th European Young Cereal Scientists & Technologists Workshop, Viterbo, Italy, 03.-05.08.2009, p. 17.


The high-speed photometer of Cassini’s Ultraviolet Imaging Spectrograph (UVIS) collected data from stellar occultations across Saturn’s rings at unprecedented high resolution over a wide range of viewing geometries. Because photon counts are described by Poisson statistics, we expect a variance equal to the mean in the absence of intervening ring material. However, most ring ‘particles’ are truly aggregates of smaller particles, ranging from micron-size dust to tens of meter-sized boulders, and if the sizes of these aggregates are not small relative to the field-of-view over a single integration period, they introduce excess variance from which we can glean further information about the sizes of particles and clumps. This is particularly relevant in the A ring, where non-axisymmetric self-gravity wakes are ubiquitous. Larger elongated clumps nicknamed straw have been directly imaged in the troughs of strong density waves (Porco et al., 2005, Science, 307, 1226-1236). In this work we present a survey of the statistical moments of variance and skewness for several ring stellar occultations at two strong density waves from different ring regions, Janus 2:1 and Mimas 5:3, over a variety of viewing angles. The line-of-sight distance from Cassini to the rings affects the measurement area due to the scattered signal and diffraction, and different viewing angles provide measurements of the same ring material with different aspects to potentially reveal the three-dimensional structure of clumps. We calculate an effective particle size per integration area, R, derived by Colwell et al., (2018, Icarus, 300, 150-166) and find similar values for R in both peaks and troughs across density waves as well as within density waves and in adjacent regions. We observe strong statistical similarity between troughs and regions adjoining the waves with overall higher skewness in the A ring, indicating more clumping and greater asymmetry in this region than in the inner B ring region.


In this paper, we present a novel and effective fault detection and diagnosis (FDD) method for a wind energy converter (WEC) system with a nominal power of 15 KW, which is designed to significantly reduce the complexity and computation time and possibly increase the accuracy of fault diagnosis. This strategy involves three significant steps: first, a size reduction procedure is applied to the training dataset, which uses hierarchical K-means clustering and Euclidean distance schemes; second, both significantly reduced training datasets are utilized by the KPCA technique to extract and select the most sensitive and significant features; and finally, in order to distinguish between the diverse WEC system operating modes, the selected features are used to train a bidirectional long-short-term memory classifier (BiLSTM). In this study, various fault scenarios (short-circuit (SC) faults and open-circuit (OC) faults) were injected, and each scenario comprised different cases (simple, multiple, and mixed faults) on different sides and locations (generator-side converter and grid-side converter) to ensure a comprehensive and global evaluation. The obtained results show that the proposed strategy for FDD via both applied dataset size reduction methods not only improves the accuracy but also provides an efficient reduction in computation time and storage space.


Tilt-up construction has been proven to be a preferred construction method for many low- to mid-rise buildings and is used around the world, typically in commercial applications. The behaviour of embedded steel plates in precast tilt-up construction has, however, rarely been studied and is not well understood. In this work, six concrete panel specimens, each with an embedded steel plate in the centre, were designed and cast following American Concrete Institute (ACI) procedures, and tested until failure. The ACI code equations for the design of embedded steel plates were found to be too conservative. Furthermore, the results indicate that across-the-board code equation standardisation is unrealistic. The finite-element computer program Abaqus was used to develop a numerical model for tilt-up wall specimens. The model successfully simulated the behaviour of the tested specimens. The numerical model can therefore be used as an accurate design method for embedded steel plate supports that directly accounts f...


We review the basic principles of Quantum Field Theory (QFT) in a brief but comprehensive introduction to the foundations of QFT. The principles of QFT are introduced in canonical and covariant formalisms. The problem of ultraviolet (UV) divergences and its renormalization is analyzed in the canonical formalism. As an application, we review the roots of Casimir effect. For simplicity, we focus on the scalar field theory but the generalization for fermion fields is straightforward. However, the quantization of gauge fields require extra techniques which are beyond the scope of this paper. The special cases of free field theories and conformal invariant theories in lower space-time dimensions illustrate the relevance of the foundations of the theory. Finally, a short introduction to functional integrals and perturbation theory in the Euclidean formalism is included in the last section.


Subjekt of my bachelor's thesis is "Analysis of the customer's satisfaction of the company iStyle Brno. The comapany is aimed at sale of IT of brand Apple and providing services from the area of IT. To draw up my project I must surveyed a marketing research, aimed at find out the customer's satisfaction in the store iStyle Brno. The inquiry proceeded by means of the questionnaire. In the theoretic section I executed literature search relating to customer's satisfaction and quality providing services. In conclusion my bachelor's thesis I work up suggestions to increasing consciousness about the store in Brno and customer's satisfaction and consequently I made risk and cost analyses.


A new encapsulation method was investigated in an attempt to develop an improved palladium packing material for hydrogen isotope separation. Porous wall hollow glass microspheres (PWHGMs) were produced by using a flame former, heat treating and acid leaching. The PWHGMs were then filled with palladium salt using a soak-and-dry process. The palladium salt was reduced at high temperature to leave palladium inside the microspheres.


The present invention relates to an architecture for the pixel distortion compensating the flexible substrate and a manufacturing method comprising the pixel architecture including a display. The present invention provides a pixel architecture for a flexible substrate of a flexible display distortion in the compensating, the architecture comprising: a first layer comprising a thin film transistor on a flexible substrate (the TFT); a second layer, the deployment over said first layer, the second layer comprises coupled to the TFT, a pixel electrode for receiving a signal from the TFT; and a third layer, comprising means for filtering light displayed by the pixel filter the color, wherein the third layer and the second layer are aligned such that the color filter is substantially aligned with the pixel electrodes, the alignment of the flexible substrate is made in the first layer distortion caused distortion compensating.


The reproductive potential of the nematode Ditylenchus destructor was evaluated on two reported hosts, alfalfa (Medicago sativa) and red clover (Trifolium pratense), and three crops of unknown host status, corn (Zea mays), oat (Avena sativa), and snapbean (Phaseolus vulgaris), in microplot, greenhouse, and laboratory experiments. Potato and fallow treatments were included for comparison. Relative to the potato cultivar Norland, snapbean was a good host, red clover and corn were intermediate hosts, alfalfa was a poor host, and oat was a nonhost for nematodes grown in vitro in monoxenic cultures (.)


In the past 100 years, with the intensification of natural climate change and human activities, global warming has become an indisputable fact. According to the IPCC's Fifth Assessment Report, the global warming of 0.5% between 1880 and 2012 was 0.85°C, the last 30 years is the warmest 30 years in the last 1400 years, and it is clear that warming is an indisputable fact that one of the main manifestations of global warming. Due to the limitations of phenological data, there are relatively few studies on the phenology of herbaceous plants by scholars at home and abroad. Now this paper will illustrate the effects of solar activity, volcanic activity and human activity on global warming., and will concern phenology to the effects of global warming on plant growing season, germination and growth. Understanding of the phenological response mechanisms of plant warming remains limited. The interaction between many promoters makes it difficult to model and predict changes in plant figuration. In the future, researchers should focus on how to mitigate global warming trends and effective measures to protect the earth's ecological environment. This paper could help people understand the importance of climate and plants to humanity, arousing people's attention to protecting the ecological environment.


In human contact, emotion is very crucial. Attributes like words, voice intonation, facial expressions, and kinesics can all be used to portray one's feelings. However, brain-computer interface (BCI) devices have not yet reached the level required for emotion interpretation. With the rapid development of machine learning algorithms, dry electrode techniques, and different real-world applications of the brain-computer interface for normal individuals, emotion categorization from EEG data has recently gotten a lot of attention. Electroencephalogram (EEG) signals are a critical resource for these systems. The primary benefit of employing EEG signals is that they reflect true emotion and are easily resolved by computer systems. In this work, EEG signals associated with good, neutral, and negative emotions were identified using channel selection preprocessing. However, researchers had a limited grasp of the specifics of the link between various emotional states until now. To identify EEG signals, we used discrete wavelet transform and machine learning techniques such as recurrent neural network (RNN) and k-nearest neighbor (kNN) algorithm. Initially, the classifier methods were utilized for channel selection. As a result, final feature vectors were created by integrating the features of EEG segments from these channels. Using the RNN and kNN algorithms, the final feature vectors with connected positive, neutral, and negative emotions were categorized independently. The classification performance of both techniques is computed and compared. Using RNN and kNN, the average overall accuracies were 94.844 % and 93.438 %, respectively.


DNA damage resistance is a major barrier to effective DNA-damaging anticancer therapy in multiple myeloma (MM). To discover novel mechanisms through which MM cells overcome DNA damage, we investigated how MM cells become resistant to antisense therapy targeting ILF2, an important DNA damage regulator in MM (Marchesini et. al., Cancer Cell 2017). We continuously treated JJN3 and KMS11 cells with an ILF2-targeting antisense oligonucleotide (ILF2 ASOs) or control non-targeting antisense oligonucleotide (NT ASOs). Whereas KMS11 cells maintained a high level of DNA damage activation and a significantly increased rate of apoptosis after 3 weeks of ILF2 ASOs treatment, JJN3 cells overcame ILF2 ASO-induced DNA damage activation and became resistant to ILF2 ASOs treatment.
 To evaluate whether continuous ILF2 ASOs exposure could lead to the selection of MM clones intrinsically resistant to ILF2 ASO-induced DNA damage, we performed single-cell RNA seq (scRNA-seq) analysis of JJN3 cells treated with NT or ILF2 ASOs for 3 weeks. Our analysis divided JJN3 cells into 2 main clusters that were independent of treatment (Fig. 1A), suggesting that persistent exposure to ILF2 ASOs did not induce clonal selection. Differential gene expression analysis of NT ASO- and ILF2 ASO-treated cells in each of these clusters revealed that DNA damage resistant ILF2 ASO-treated cells had significantly upregulated oxidative phosphorylation (OXPHOS), DNA repair signaling, and reactive oxidative species (ROS). Consistent with these results, metabolomic analysis of JJN3 cells after long-term exposure to ILF2-ASOs showed a significant enrichment of tricarboxylic acid cycle (TCA) intermediates (Fig. 1B). ILF2-ASO-resistant MM cells were significantly more sensitive to the OXPHOS inhibitor IACS-010759 than ILF2-ASO-sensitive cells were. These data suggest that MM cells can undergo an adaptive metabolic rewiring to restore energy balance and promote survival in response to DNA damage.
 We then hypothesized that ILF2-ASO-resistant cells' metabolic reprogramming relies on the repair of DNA damage induced by ILF2 depletion or by the generation of ROS from activated mitochondrial metabolism and that targeting DNA repair proteins involved in these processes overcomes DNA damage resistance. We used a CRISPR/Cas9 library screening strategy to identify DNA repair genes whose loss of function suppresses MM cells' ability to overcome ILF2-ASO-induced DNA damage. Compared with those in NT-ASO-treated cells, DNA2-targeting sgRNAs were significantly depleted after 3 weeks of treatment in ILF2-ASO-treated JJN3 cells but not in ILF2-ASO-treated KMS11 cells. These data suggest that DNA2 is needed to promote resistance to ILF2 depletion. Accordingly, the DNA2 inhibitor NSC105808 (NSC) significantly enhanced ILF2-ASO-induced apoptosis in JJN3 cells. These data gain added significance in light of previous findings that DNA2 is a nuclear and mitochondrial DNA nuclease/helicase that enables cancer cells to counteract the DNA replication stress and mitochondrial oxidative DNA damage induced by DNA-damaging agents. Accordingly, we observed that DNA2 was mainly localized into the mitochondria of MM cells.
 To dissect the mechanisms of DNA2 inhibition-induced synthetic lethality, we evaluated whether DNA2 activity is essential to maintain activated OXPHOS, which ILF2-ASO-resistant cells require to survive. The quantification of mitochondrial respiratory activity in NT-ASO-and ILF2-ASO-treated MM cells exposed to NSC for 72 hours showed that DNA2 activity inhibition significantly decreased the oxygen consumption rate while increasing ROS production in only ILF2-depleted cells. Transmission electron microscopy analysis showed that NSC-treated ILF2-depleted cells had fragmented mitochondrial cristae structures, whose perturbations affect the OXPHOS system structure and impair cell metabolism. These data suggest that DNA2 is essential to counteract oxidative DNA damage and maintain mitochondrial respiration after MM cells' metabolic reprogramming.
 In conclusion, our study has revealed a novel mechanism through which MM cells can overcome DNA damage activation. Further studies will clarify whether targeting DNA2 is synthetically lethal in tumors with increased demand of mitochondrial metabolism.
 Figure 1 Figure 1.

 Konopleva: Genentech: Consultancy, Honoraria, Other: grant support, Research Funding; AbbVie: Consultancy, Honoraria, Other: Grant Support, Research Funding; Sanofi: Other: grant support, Research Funding; Ablynx: Other: grant support, Research Funding; Reata Pharmaceuticals: Current holder of stock options in a privately-held company, Patents & Royalties: intellectual property rights; Agios: Other: grant support, Research Funding; Cellectis: Other: grant support; Rafael Pharmaceuticals: Other: grant support, Research Funding; Calithera: Other: grant support, Research Funding; Forty Seven: Other: grant support, Research Funding; Ascentage: Other: grant support, Research Funding; AstraZeneca: Other: grant support, Research Funding; F. Hoffmann-La Roche: Consultancy, Honoraria, Other: grant support; Stemline Therapeutics: Research Funding; Novartis: Other: research funding pending, Patents & Royalties: intellectual property rights; Eli Lilly: Patents & Royalties: intellectual property rights, Research Funding; KisoJi: Research Funding.


The aquatic environments which represent a vital resource for man are threatened by various pollution of anthropogenic origin. Chlorophyll-a being the consequence of the nutrient enrichment of water and linked to primary production, participates in the degradation of water quality by the proliferation of phytoplankton. Algal development depends on physical, chemical and biological factors in the aquatic environment. The objective of the study is to determine a better model for predicting chlorophyll-a concentrations from the environmental variables of the waters of the Ebrie lagoon. The predictive model by multilinear regression of total chlorophyll-a allowed to generate excellent statistical indicators and final descriptors of influence (R2 = 0.9076; RMCE = 0.1296; F = 216.009). The external validation tests of Tropsha et al and Roy et al are all verified and the model obtained has a good predictive power. Thus, suspended solids (SS) (33%) and pH (23%) were the most influential descriptors of the water model of the Ebrie lagoon. At the level of the applicability domain of the model the value of the threshold lever is h*=0.875. The observations of the training set are all within the domain, so the prediction of chlorophyll-a concentrations is reliable.


Abstract : Variable capacitance electrostatic generators are capable of rugged efficient operation and high power output. An exposition is given of a variable capacitance electrostatic energy conversion system, employing self-contained excitation, for electrical pulsed power generation, including mathematical analysis and comment on practical realization.


The RANS (Reynolds averaged Navier–Stokes) equations can yield significant error when applied to practical flows involving shock waves. We use the interaction of homogeneous isotropic turbulence with a normal shock to suggest improvements in the k–e model applied to shock/turbulence interaction. Mahesh et al. [J. Fluid Mech. 334, 353 (1997)] and Lee et al. [J. Fluid Mech. 340, 22 (1997)] present direct numerical simulation (DNS) and linear analysis of the flow of isotropic turbulence through a normal shock, where it is found that mean compression, shock unsteadiness, pressure-velocity correlation, and up-stream entropy fluctuations play an important role in the interaction. Current RANS models based on the eddy viscosity assumption yield very high amplification of the turbulent kinetic energy, k, across the shock. Suppressing the eddy viscosity in a shock improves the model predictions, but is inadequate to match theoretical results at high Mach numbers. We modify the k equation to include a term due to s...


..................................................................................................................... vii LIST OF TABLES ........................................................................................................... xiv LIST OF FIGURES ......................................................................................................... xvi LIST OF ABBREVIATIONS/SYMBOLS .................................................................... xxiii CHAPTER ONE: INTRODUCTION ..................................................................................1 REFERENCES ..................................................................................................................19 CHAPTER TWO: COHERENT EXCITON DELOCALIZATION IN A TWO-STATE DNA-TEMPLATED DYE AGGREGATE SYSTEM ......................................................26 Abstract ..................................................................................................................28.................................................................................................................28 2.


Designing effective marketing programs requires forecasting the choice strategy a consumer will use in a given decision environment. Both simplifying and optimizing considerations may affect the strategy used. This study found individuals' perceptions of different strategies as simplifiers and optimizers varied, with number of options being reviewed operating as a moderator.


Pot size is vital for raising of nursery seedlings. Different sizes of pots are needed for various tree species. An experiment was set up to investigate the best pot size for Cupressus lusitanica and Grevillea robusta species. The experiment was laid down as a RCBD with 8 treatments replicated 3 times. Treatments comprised of 4 different pot sizes as follows: large, medium, small and smallest as well as two species. Forest soil mixture was used for potting and 10 pots were used per each treatment per replicate while 7 plants were randomly selected for sampling. The experiment was carried out from September 2017 for a period of 8 months. The variables measured included; shoot, foliage and roots. ANOVA was done using Genstat package while the means were separated at P< 0.001 using LSD. The results showed that large pots had significantly (P<0.001) higher values in height, shoot fresh biomass, total fresh plant biomass and seedling stem volume compared with the other pot sizes. Large pots also showed significantly higher root collar diameter (6.23 mm) compared with the medium pot (4.33 mm). For species, Cypress showed significantly superior height (27.84 cm) and number of leaves (24.52) compared with Grevillea (18.73 and 18.27 cm respectively). In conclusion, shoot fresh biomass and total fresh plant biomass were positively correlated with pot size. This study recommends the use of large pots for raising Grevillea and Cypress seedlings in the nursery since they take 8 months to attain planting size.


Heat stress may limit the growth of turfgrasses through the induction of oxidative stress, causing cellular and physiological damage. The objective of the study was to examine the association of heat and oxidative stresses between warm-season (C4) and cool-season (C3) turfgrasses. Plants of zoysiagrass (Zoysia matrella L. Merr. cv. Manila) (C4) and tall fescue (Festuca arundinacea Shreber cv. Barlexus) (C3) were exposed to optimal temperature conditions (24 8C for tall fescue and 34 8C for zoysiagrass) or heat stress (10 8C above the respective optimal temperature for each species) in growth chambers. Zoysiagrass exhibited less severe decline in turf quality and photochemical efficiency and less severe oxidative damage in cellular membranes as demonstrated by lower membrane electrolyte leakage and lipid peroxidation compared with tall fescue when both were exposed to heat stress. The activities of superoxide dismutase (SOD) and peroxidase (POD) declined with heat stress for both species, buttoalesserextentinzoysiagrassthanintallfescue,whereascatalaseactivitydidnotchangesignificantlyunderheat stress and did not exhibit species variation. Our results demonstrate that the superior heat tolerance in zoysiagrass in comparisonwithtallfescuewasassociatedwithgreateroxidativescavengingcapacityasaresultofthemaintenanceof higher SOD and POD activities.


With rapid development of motorization the demand-supply conflict in urban transport becomes serious,and it is hard to get smooth traffic flow.Considering that road network,parking and atmosphere are the most likely aspects affected by urban motor vehicle traffic,an idea is presented about urban motorization control.With in-depth study on urban road network capacity,parking area capacity and the environment capacity a bi-level programming model is developed for urban motorization development taking into consideration of the relationship between dynamic traffic distributing and urban transport system capacity.This establishes an theoretical base for harmonious development between motorization and urban sustainable development,also it provides a decision-making method for management department.


The Duchenne type of muscular dystrophy, transmitted by sex-linked recessive inheritance, is the commonest and most progressive form of the disease. The primary defect is unknown. Occasionally the symptoms may be seen in females, but in contrast to the severity and progression of the disease in boys, the course is mild. In the present investigations we have attempted to ascertain, by electron microscopy, the structural lesions that might initiate the series of changes in the degeneration of the muscle, to correlate these early alterations in muscle with the elevations in serum creatinephosphokinase (CPK) and perhaps explain the mechanisms responsible for the transfer of CPK from muscle to blood. It was postulated that the early anatomic changes in the fine structure of the muscle might be revealed more readily in carriers in whom the alterations are apt to be less advanced than those already observed in the early diseased state in patients. Therefore, in several kinships, we studied patients and female carriers, and used the normal male siblings and fathers as controls. The pathologic alterations in muscle in Duchenne muscular dystrophy have been studied extensively by light microscopy since the early work of Erb, but electron microscopic studies are comparatively few and incomplete. The investigations reported so far on the pathology of muscle in female carriers have been limited to light microscopy. It is hoped that this report will meet the present need for information on the evolution of the morphologic changes from the early to the advanced stages of the disease as revealed by electron microscopy. Elevations in serum CPK levels have been demonstrated by a number of investigators in patients and in female carriers. The mechanism of the increase of CPK in serum is not known. In an earlier report we1 described the structural changes demonstrated by electron microscopy in muscle during different stages of serum CPK elevations in patients. In the present investigations observations on anatomic changes and correlation with serum CPK activities were extended to female carriers, some of whom had elevated enzyme levels and others who did not.


This study was motivated from the urge of reinterpreting criminal verses contextually that still pay attention to the role of text, context and contextualization. The ma'nā-cum-magzā hermeneutics method was chosen as a method of interpretation in this study because it was considered moderate hermeneutics. It is a method of interpretation resulting from the synthesis of subjectivist and objectivist hermeneutics to become subjectivist- cum-objectivist. Because the object of this study was verses of criminal law, the theory used was legal theory, namely restorative justice, on the basis that this study was conducted to find the principles of restorative justice in criminal law verses. Therefore, this study focused on answering three problem formulations. First, why is it necessary to reinterpret the verses of the Al-Qur'an regarding the crime of murder? Second, how is the reinterpretation of the verses of the Qur'an regarding the punishment for murder with maʻnā-cum- magzā hermeneutics? Third, how relevant is the principles of restorative justice with the results of the reinterpretation of the verses of the Qur'an regarding the crime of murder? This study concludes that First, the verses of the Qur'an regarding the crime of murder still need to be reinterpreted because the context at the time of revelation was different from that of today. These verses cannot be taken literally and statically. Second, by using the maʻnā-cum-magzā hermeneutic method, the principles of restorative justice contained in the verses of the Al-Qur'an about murder can be explored. The principles of restorative justice excavated from the criminal law on murder are the main basis for solving criminal cases. Third, the relevance of the principles of restorative justice can be seen from the analysis of the keywords 'ufiya, ma'rūf, ihsān, and 'aṣlaḥa. Apology, reparation, and transformation are the principles of restorative justice contained in these keywords. In the end, the reinterpretation of criminal law verses is an effort to comprehend the text contextually without changing the spirit of shari'a, in accordance with the objectives of Islamic law, namely realizing the benefit of mankind.


SUMMARY The impact of borderline personality disorder on family members of persons with BPD is articulated best by family members themselves. Despite an increase in research demonstrating more hopeful outcomes for the diagnosis, many mental health professionals remain unaware of recent advances in BPD treatments and therapies. This lack of awareness has dramatic consequences not only for patients, but for their families as well. This chapter describes the personal experiences of 12 family members with relatives with BPD. Expressed in one-hour semi-structured interviews, the family members' individual accounts centered on five key areas of their lives with their ill relative: (1) difficulty accessing current evidence-based knowledge about BPD and treatments; (2) a stigmatizing health care system; (3) prolonged hopelessness; (4) shrinking social networks; and (5) financial burdens. To improve the quality of services available to family members affected by BPD, social workers must educate themselves about the availability of professionals trained in BPD, BPD-specific treatment options, and BPD information resources.


Business communication plays an important part in modern business activities and is an essential part in this information economy. This paper aims to discuss how to be an effective business communicator. First, it analyses the process of business communication. Then it discusses how to be a good listener and get more effective information in the communication. At last, it tells the importance of non-verbal communication skills.


Electric vehicles (EVs) are viewed as the future vehicles since they are very efficient, environmentally friendly (no pollution and less noisy) and helpful for power regulation in grid through various charging topologies. In order to analyze the performance of EV, proper hardware testing model is required and hence in this work basic EV testing model is considered for the real time data analysis. Proposed EV testing model incorporates trending IOT technology to Cloud based real time data acquisition, provides the live interaction with electric vehicle. This enables user to study the performance parameters in fixed time interval with varied drive cycles. This paper presents the details of Basic EV module built using Arduino controller to acquire and process real time data for Battery Electric Vehicles (BEVs) through IoT in which all acquired performance parameters are stored in things speak server and analyzed using MATLAB


This study tackles the misalignment challenges between Business Process
Management (BPM) and Human Resource Management (HRM), and more specifically
regarding employee appraisals and rewards. By following the Design-Science Research
(DSR) methodology, we will develop artefacts to help managers obtain an overview of
what to change for better aligning appraisals and rewards to their business processes.
This work-in-progress intends to contribute to a better understanding of this BPM-HRM
alignment, and will offer practical solutions to a contemporary business issue.


I followed the man around a large room. He was dressed in a white coat and moved so briskly that it flapped like a kite in the wind. No, I wasn't pursuing a doctor. The man was a judge of pigeons - the event, a Grand National Pigeon Show. As each show season approaches, breeders begin to envision receiving ribbons, trophies, and cash prizes. They want to impress those men in white coats. They want to feel they've advanced in a hobby they somehow can't live without, to open the show report and find their name listed among the top breeders in the country. A few exhibitors realize their aspirations. Others shake their heads and chalk it up to fate, bribery, or knowing the right people. Now, I won't deny that these factors can and probably do play some role in all bird shows. But there are other considerations. Chances are the exhibitor with consistent wins in the showroom has learned a few basics in regards to preparing both his birds and himself for competition. Let's look at a few of these, often ignored, "keys" to showroom success. Let's start off with the bird. After all, you may be dressed like a million dollars, with every hair in place, but the judge isn't looking at you (at least he shouldn't be). It's logical to assume that you selected a few of your very best specimens for the show. In other words, much as I'm allergic to standard books, I hope you looked at the standard more than once. You would be wise to have nearly memorized the standard so that you know what an acceptable Indian fantail looks like. And, should you find you possess no acceptable Indians, enter a good, clean bird anyway. You'll learn something just from the experience. (For one thing you'll learn whether or not you can handle criticism. Ha!) And, your fellow exhibitors may be able to give you some good advice for improving the quality of your stock. Now that you have selected the birds you wish to enter, the real job begins. Birds love to bathe. Everyone knows that. Yet, an awful lot of birds must crawl into their drinking vessel if they want to wet their plumage. From several feet away, these birds may appear to be clean and well-cared for. But a judge picks up each bird, handles it, even examines the feathering. If he finds soiled feathers, or bug holes, your show is over before it began. Bright, warm days are the best times to offer a bath. But simple bathing will not eliminate lice and other creepy crawlies that love to live on your birds. Believe me, even a clean aviary is not completely free of these vermin. For this reason it is wise to resort to a pigeon dip once or twice a year. Sodium fluoride makes an excellent dip for pigeons and doves. It is simple and effective when used as follows: Mix one heaping tablespoon of sodium fluoride plus one tablespoon Ivory liquid in a gallon of tepid water. Stir until the powder has dissolved. Dip pigeons in the mixture, head and all. Let the birds dry naturally in the sunshine. The soap allows the sodium fluoride to penetrate the minuscule pores of the feathers where it remains and helps ward off lice for six to eight months. (After applying this technique, I found that those telltale pinholes in my birds' feathers ceased to occur.) Don't be overcome with guilt just because your flock has that woebegon appearance after their dunking. You haven't inflicted pain, and, unless the weather is cold or draughty, you haven't chanced their health. In a few hours you'll notice a remarkable change. Feathers will have more lustre, a softer, silkier texture, and best of all, you'll have freed your entire loft of these troublesome bugs. If you happen to live in one of the colder areas of the country, where dipping can't be done often, you may wish to supplement the procedure with a poultry dusting. I use a Pet, Poultry and Livestock Dust once a year as an additional precaution, dusting liberally under the wings and around the vent. The powder is helpful in controlling both lice and mites. Frequent use of both the dip and the powder plus occasional mild bath watet will insure you against the embarrassement of having your show birds disqualified. You have half the battle licked if your birds are carefully selected and free from bugs. The additional steps you take will be your icing on the cake. Some exhibitors like to use vaseline on their birds' feet to give them more lustre. That's fine as long as the bottoms of the feet aren't adorned with mudballs and excrement. Generally speaking, if loft floors are kept clean and dry, you won't be having to deal with any of these bugaboos. If you do have a foot problem or two, a cotton swab dipped in alcohol will help loosen the build-up while disinfecting the soft pad of the bird's foot. How much can you do to help mother nature along? In bird showing there are some fine lines between grooming and cheating. While it is certainly acceptable to do a little plucking here and there, you have to stop short of sewing-in feathers where there aren't any. I've heard stories about fanciers using needle and thread to sew in a flight where it was missing. Problem with this was not only the question of ethics, but the guy used pink thread on a white flight. Judges are not stupid. In some breeds, such as the longfaced clean-legged tumbler, a short beak is one of the important hallmarks of the breed. In day-to-day maintenance, filing and clipping the beak is necessary. Thus, it would not be considered unethical to file the showbird's beak before bringing it to the exhibit hall. On the other hand, it would be scandalous to use your secretary's correction fluid to paint a colored feather white. In other words, use your good common sense. And, if in doubt, ask. About a week before the big show is to take place, it would be a good idea to move your entries into a show-type cage. It will help accustom them to small quarters and will allow you to handle them frequently.


Submission October 20, 2015 DEADLINES Manuscript for Review January 15, 2016 Final Manuscript due March 24, 2016 Prospective authors are invited to submit your abstract in 300-400 words to: (1) Online abstract submission or email email@example.com; (2) One of TPC members (session organizers, see backside); or (3) ISOPE-2016 TPC, 495 North Whisman Road, Suite 300, California 94043-5711, USA (Phone 1-650-254-1871: Fax 1-650-254-2308), observing the above key dates. Abstract should emphasize the significance of the results and/or the originality. Abstract must include the paper title, all authors' and co-authors' names, affiliations, full addresses, and telephone and fax numbers and E-mail address of the corresponding author. Some 100+ technical and industry sessions with participation from some 50 countries will emphasize tentative topics: OFFSHORE TECHNOLOGY & OCEAN ENGINEERING Deeper Water System, Install & decommission Subsea Umbilicals & Flexible Pipe FPSO, SPAR, TLP & Compliant Structures Station-keeping; DPS and Mooring LNG, FSRU, FLNG, LNG Plant CFD, Hydroelasticity, VLFS METOCEAN & Remote Sensing, Climate, Waves, Sea State, Arctic ISO, Code and Standards FRONTIER Energy Resources Tech Symp Clean Energy, Clean Coal, Oil Shale & sand Deep-Ocean Mining, Gas Hydrates Deep-Ocean Mining, Methane Hydrates RENEWABLE Energy & Environ Symp. Offshore Wind Turbines, Fixed & Floating , Ocean Energy, Waves, Tidal, Current, OTEC Reliability, Subsea Energy Storage Dynamics & Control, Design & Optimization, ENVIRONMENT Oil Spill & Environ, Coastal, Arctic & Antarctic Carbon Capture CCS GEOTECHNICAL ENGINEERING Soil Properties and Improvements, Geohazards Modeling & Numerical, Slope Stability Earthquake/Scour/Arctic Geotechnical Eng Pile-Soil Interaction, Suction Piles Foundations/Testing & Instrumentation OFFSHORE MECHANICS HYDRODYNAMICS & CFD CFD and NWT, and Hydroelasticity Waves; Loads, internal& external Wave-Structure Interaction Dynamics METOCEAN, Tsunami, rogue waves Vortex Shedding & VIV SLOSHING & LNG DESIGN Symposium TSUNAMI & Safety Symposium COASTAL ENGINEERING Tsunami, Long waves, Storm Surge, Wave Impact, Group Waves Breakwaters and Coastal Protection Port & Harbor, Sediment, Coastal Monitoring CFD & Computational Mechanics SUBSEA, PIPELINES, RISERS Deepwater & Arctic Pipeline, Subsea & Installation, Flow Assurance, Deepwater Riser & Design, Integrity Management, Pipe Soil interactions, Materials, Safety& Reliability, Buckling, Flexible Pipe & Umbilicals Vortex Shedding &Vibration Suppression SAFETY & RELIABILITY, MECHANICS Risk, Safety and Reliability Engineering Reliability, Collision, Impact, Damages Health Monitoring Structural Mechanics, Ultimate Strength Earthquake Engineering ARCTIC SCIENCE & TECH Symposium Arctic Resources, Infrastructure, Logistics. Arctic Structures, Design, Icing, Permafrost Arctic Transport: Shipping, Pipelines Ice Mechanics, Loads, Modeling, Management Polar Meteorology, Pack Ice, Oceanography Arctic Environment, Ice Basin Testing HIGH-PERFORMANCE MATERIALS Additive Manufacturing Symposium High-Manganese Steel Symposium Strain-Based Design Symposium Asset Integrity Symposium Arctic Materials Symposium Pipeline Integrity Symposium Nanotechnology Welding Technology Steel and Metal Alloy Development Composites, Smart Structures. Fatigue, Fracture, & Functional Coating Structural Integrity; Tubular Structures ADVANCED SHIP TECHNOLOGY Green Ship; Digital Shipbldg, Naval Systems, Ship Hydrodynamics and Structures UNDERWATER SYSTEMS & OCEANOLOGY Deep-Ocean AUV, ROV, Gliders, Monitoring Robotics & Aquabiomechanism Optics, Acoustics, Communication Smart Vehicles, Multiple Vehicles PAPER REVIEW AND PUBLICATIONS: All papers will be rigorously reviewed prior to acceptance. The accepted papers will be included in the Conference proceedings, which will be available at the Conference and for worldwide distribution. Papers of archival value will be further considered for publication in International Journal of Offshore and Polar Engineering or Journal of Ocean and Wind Energy (ISSN 2310-3604) www.isope.org. Special ISOPE room rate at top-class Rodos Palace Hotel starts from €95 / night and up. Social Events and Sightseeing tours are arranged. First Call For Papers


Background: Increased expression of smooth muscle and nonmuscle myosin heavy chains has been previously reported in animal models of cardiac allograft rejection. However, altered expression of β‐myosin heavy chain in human cardiac rejection has not been determined.


The apparent discrepancy between theory and experiment in low‐velocity electronic stopping of heavy ions is shown to be resolved for several representative cases by taking into account the velocity dependence of both the effective charge of the ions and of the atomic stopping power for fixed ionic charge. A new formula for the electron density dependence of the stopping number is introduced, based on recent work by Vager and Gemmell.


This study through the use of the concept and property of H-bases,gets a new method that use the intersect of random q times algebraic curve and random m times algebraic curve to construct the PPSN(Properly Posed Of Nodes,for short) along plane curve,thus it will generalize the obtained results to the most general case,gets a further understanding of bivariate interpolation for PPSN's geometry construction and essential characteristics,gets a general method and a stronger practical deduction to construct the ppsn along space algebraic curve,and provides a theory basis for the practical application of multivariate polynomial interpolation in curve shape design and finite element.


The fracture behavior of bulk Zr55Al10Ni5Cu30 amorphous alloy under uniaxial compression at high temperature has been investigated. At room temperature, a crack with serrated edge appeared on the ridge of veins at the fracture surface for the bulk Zr55Al10Ni5Cu30 amorphous alloy. At high temperature, the compressive fracture surface of bulk Zr55Al10Ni5Cu30 amorphous alloy became much rougher than that at room temperature, and steps appeared on the fracture surface. With increasing the temperature, a different pattern from the vein appeared on the fracture surface at high temperature, which is very similar to the flowing-liquid solidified immediately. This type of fracture is most likely due to the adiabatic heating created by plastic flow.


Publishers details for: Confronting Fiji Futures by Akram-Lodhi, A. Haroon (ed.), Canberra: Asia Pacific Press at the Australian National University, 2000. xv + 321 pp., bib., figs, index, notes, tables. Price: A$30 (paper).


Need for sophisticated automotive electronics is increasing as per the customers demand for luxury, comfort and safety grows. In addition to this computational power of the microcontrollers, FPGAs and processors have also reached new heights forcing vehicle OEMs (Original Equipment Manufacturers) to modify their conventional vehicle networking architecture to handle large amount of data's. This paper reviews traditional and latest vehicle network protocols and compares their performance, speed and its area of application.


Objective To study the CT findings of HLD and improve its detection rates.Methods Fifteen cases of this disease verified by biochemisty and disgonstic therapy were prospectively.Results The CT images were the same hypodense lesions in the both sides of the nuclei basales in the brain.Conclusion CT appearance of HLD have characteristic feature,so CT is valuable to diagnose this disease.


By the example of solver FlowER, the questions of flow modelling, turbulence modelling and numerical technique are discussed. Numerical results are presented for turbomachinery flows including unsteady effects, leakages, film cooling and optimization of blade shape


The purpose of the study was to assess the distribution of tumor-infiltrating T-, B-lymphocytes and natural killer cells in various molecular subtypes of invasive ductal breast cancer and to establish their relationship with the degree of tumor differentiation. Materials and methods. The basis of the scientific work was a complex morphological, including immunohistochemical study of 193 cases of invasive ductal breast cancer. General histological processing of the samples was carried out in accordance with the standard technique. Immunohistochemical studies for CD3, CD20, CD56, ER, PR, c-erbB2, Ki-67 were performed according to the manufacturer's protocol with the control of samples. The grade of malignancy was determined according to the modified scheme of P. Scarff, H. Bloom and W. Richardson. The presence, localization, and expression intensity of diagnostic and prognostic biomarkers CD3, CD20, and CD56-positive cells (T-, B-, and natural killer cells, respectively) were determined using the new bioimage analysis software QuPath. Results and discussion. The differences obtained in our study varied depending on the subpopulations of immune cells and their location in the tumor tissue. The density of T and B lymphocytes was higher within the tumor and in the invasive margin in the non-luminal phenotypes compared to the luminal A and B phenotypes. Compared to the density of T-lymphocytes, the B-cell infiltrate was significantly (p <0.01) less pronounced in tumors of both luminal and non-luminal phenotypes. The lowest density of natural killer cells among tumor-infiltrating lymphocytes was found within the tumor of luminal subtypes. The percentage of infiltrates of T and B cells both within the tumor focus and in the invasive margin, as well as natural killer cells in the invasive margin, was significantly lower with G1 and G2 than with the degree of differentiation G3 (p <0.01). As for intratumoral natural killer cells, differences were found only between the degree of differentiation of G2 and G3, and the differences between G1 and G2 were not statistically significant (p> 0.05). Qualitative and quantitative assessment of the intensity of expression of T-, B- and natural killer cells also demonstrated a different degree of expression of lymphocytes, depending on the molecular subtype and location of the infiltrate. The luminal subtype A was characterized by a significant predominance of mild expression (2+) CD3 both within the tumor and in the invasive margin of the tumor (p <0.05), while in the luminal B and Her2 + phenotypes, the intensity of CD3 expression prevailed at the 1+ level. Triple negative tumors were characterized by strong expression of (3+) CD3 within the tumor and in the invasive margin of the tumor in all cases studied. Conclusion. Thus, tumor-infiltrating lymphocytes in different molecular subtypes of invasive ductal breast cancer can be considered a prognostic biomarker. Our results indicate a relationship between lymphoid infiltrate and the degree of differentiation in invasive ductal breast cancer, especially in less favorable molecular subtypes


Thermal spraying techniques used on surface protection of magnesium alloy are briefly introduced,and research status of thermal sprayed aluminum coating used on surface protection of magnesium alloy is presented.The disadvantage of thermal sprayed aluminum coating used on surface protection of magnesium alloy is pointed out.The developing trend of thermal sprayed aluminum coating on the surface of magnesium alloy in future is analyzed from two aspects,spraying technics and spraying materials.Al last,two major problems of thermal sprayed Al coa-ting used on surface protection of magnesium alloy are pointed out: reducing the porosity of Al coating and improving double-effect properties with abrasion resistance and corrosion resistance of Al coating.


We use a Dense Plasma Focus (DPF) device NX2, with improved insulator, electrode, and switching configuration, and with Argon filling to concentrate the main part of its radiation near 4 A. In this case it can be used as a source for different aims in micro-lithography. One evident goal here is to increase spatial resolution of the method with the help of a source having a shorter wavelength in comparison with widely used Ne gas filling of DPF. But in particular it can be implemented in micro machining when it emits enough harder X-rays with Argon as a working gas, but it is attainable if plasma can reach Tpl=1 keV at the pinching phase. There are at least three possible ways to get the above temperature and high X-ray yield around wavelength of 4 A. One is to use a mixture of light gas (ultimately deuterium) with argon to produce hot spots by plasma necking. Another one is to increase CS velocity in pure argon. The third one is to use a mixture of heavy gas (e.g. krypton) with argon to produce separation of gases at the shock wave front of a DPF current sheath and subsequently to compress argon by a heavy shell. In the last two cases longer electrodes and lower initial pressure are needed for DPF-bank matching. Using a pinhole with a CCD matrix and a pair of folded by different foils pin diodes in all three methods we have successfully reached a reasonable yield in the above-mentioned spectral range. It was respectively about 0.4J 1.0J and 10.0J. Within all three modes of the DPF operation it was possible clearly to find a distinction between three characteristic regimes: a pinch regime, a hotspot regime, and a runaway regime.


A report discusses the second generation of the JPL Electronic Nose (ENose), an array of 32 semi-specific chemical sensors used as an event monitor to identify and quantify contaminants released into breathing air by leaks or spills. It is designed to monitor the environment for changes in air quality, and is trained to identify and quantify selected chemical species at predetermined concentrations, ranging from sub-ppm to ppth. This system has improved reproducibility for making matched arrays, allowing use of data analysis software with minimal recalibration on sensor set replacement. The Second Generation (SG) ENose is a follow-up to the first JPL Electronic Nose that was tested on an earlier space shuttle mission (STS-95). Improvements have been made to the hardware, sensor materials, and data analysis software.


The study explores the advantages of echography as a diagnostic tool. Echography was used on 100 ginecological patients, of whom 47 had undergone surgery, mostly for tumors. There was a positive correlation between the clinical diagnoses and echography findings, which were corroborated by anatomo-pathological investigations done after surgery. In IUD wearers echography can safely and effectively report on IUD location and/or translocation and consequent pathology. Beside being safe and effective echography is cheap, and helps avoiding unnecessary risks for the patients.


Background: Physical activity is one of the most important indicators of health in communities but different studies conducted in the provinces of Iran showed that inactivity is prevalent, especially among women. Objectives: Inadequate regular physical activities among women, the importance of education in promoting the physical activities, and lack of studies on the women using transtheoretical model, persuaded us to conduct this study with the aim of determining the application of transtheoretical model in promoting the physical activities among women of Isfahan. Materials and Methods: This research was a quasi-experimental study which was conducted on 141 women residing in Isfahan, Iran. They were randomly divided into case and control groups. In addition to the demographic information, their physical activities and the constructs of the transtheoretical model (stages of change, processes of change, decisional balance, and self-efficacy) were measured at 3 time points; preintervention, 3 months, and 6 months after intervention. Finally, the obtained data were analyzed through t test and repeated measures ANOVA test using SPSS version 16. Results: The results showed that education based on the transtheoretical model significantly increased physical activities in 2 aspects of intensive physical activities and walking, in the case group over the time. Also, a high percentage of people have shown progress during the stages of change, the mean of the constructs of processes of change, as well as pros and cons. On the whole, a significant difference was observed over the time in the case group (P < 0.01). Conclusions: This study showed that interventions based on the transtheoretical model can promote the physical activity behavior among women.


This paper investigates the effects of ship motion on ship-based cannon firing in terms of dynamics of ship motion and artillery shoot theory,including effects of canon base motion due to ship sway and alignment error from lever-arm effect.A novel approach based on transfer alignment is analyzed to eliminate alignment error.The simulation result shows that the influence of roll and pitch on shoot distance decreases with the increasing of shoot range,error of direction increases with roll increasing while decreases with pitch increasing.It also shows significant influence of slave inertial navigation system owing to lever-arm effect,especially with the increasing of ship sway.Moreover,a transfer alignment based on Kalman filter is used to eliminate rapidly the initial alignment error of ship-based cannon,which can improve the accuracy of the cannon′s initial setting angle.


A 55 kg micro-piggyback satellite, " μ-Lab Sat", is currently under development. One of its missions will be to release a truncated cone-shaped target and obtain camera images of it. Since there are uncertainties regarding the release direction of the target, it would be advantageous if the satellite were able to adjust its attitude to track it, performing three-axis attitude maneuvers. μ-Lab Sat is a bias momentum microsatellite with two wheels, and although such maneuvers are not easy for this hardware configuration, two algorithms have been developed to enable the satellite to track the target; one utilizes an optimal control algorithm and the other applies the sliding mode control algorithm. This paper describes these algorithms and presents the results of their evaluation by numerical simulation.


Abstract The discipline of practical theology has created a significant body of work considering the theological implications of disability and illness. Within that, less attention has been given to High Functioning Autistic Spectrum Disorder (HFASD), also described as Asperger Syndrome. It may be that this is because more attention has been focused on the associated and more easily diagnosable condition of autism. Disability theology has also recognized the existence and function of metaphor, both within the Bible and society. Emphasis on liberation has been a particular theme, with lesser attention given to hermeneutical approaches. This paper attempts to bring together the experience of HFASD together with the historical study of metaphor and, in so doing, suggests possible avenues for further research. The canonical-linguistic hermeneutic of Vanhoozer serves as a foundation for theological reflection.


It is known that in a B*-algebra every self-adjoint element is hermitian. We give an elementary proof that this condition characterizes B*-algetras among Banach*-algebras.


this article examines different animals psychology, intellect and behavior to prove that actually have complex mentality and advanced psychism. Therefore people make more effect to care about them and do not excruciate them. It was investigated, for example, that turkeys change the color of the beak depending on the emotions. Another mental complication facts are dolphins, one of the most clever and joyful creatures in the world, can die from stress during trainings, because it is not natural for them. Moreover, animals experience mental diseases. For instance, dogs that served in the war in Iraq and Afghanistan suffered from the same symptoms of post-traumatic stress disorder as people. Concerning intelligence, although animals do not have common language, culture and logical thinking, their instincts are plastic and more developed and therefore their survival skills are better. For example, the female digging wasp must, within a few weeks, before it perishes, meet with the male and perform a complex series of activities related to digging the nesting mink, building chambers in it, supplying the chambers with prey. The proof of instinct plasticity is that redstart and tomtit under unusual conditions arrange their nests in unusual for they nature places like under the roots.


A method of constructing codes with a low jump rate, called bit-block-code (BBC), is presented. The BBC has the structure of BBC, in which bits constitute a block and blocks form codes. Each bit of a block has no weight and each block has weight determined completely by its position in the circuit. The modular design for the BBC generator is also proposed where blocks are basic units of the BBC generator. The generation circuit has the characteristics of being simple, modular, and extensible. The BBC can be used as test vectors to reduce the power consumption of the circuit under test, and it can also be exploited as a code for general purposes.


The invention discloses a bathroom drying mat. The bathroom drying mat comprises a switch, a working device, a bottom case, two side plates and two air outlet plates. The working device is located inside the air outlet plates, a plurality of through holes are formed in the upper surface of the bottom case, the lower ends of the two side plates are perpendicularly connected with the two lateral sides of the bottom case respectively, the upper ends of the two side plates are connected with the lateral sides of the two air outlet plates respectively, the included angle between the air outlet plates and the upper surface of the bottom case is smaller than 90 degrees, and air outlets of the air outlet plates aligns with the upper surface of the bottom case. The working device comprises a power supply, heating electric resistance wires and a fan, wherein a switch is arranged on the outer side face of one side plate, and the power supply is connected with the heating electric resistance wires and the fan through the switch. The heating electric resistance wires and the fan are arranged, the feet can be quickly dried through blown hot air, the through holes are formed, and therefore shoe soles can be kept dry when making contact with the drying mat, the anti-skidding effect is achieved, and the bathroom drying mat is more convenient to use, ingenious in design, simple and practical, and worthy of being popularized.


In this study, a well-defined dendritic silver nanostructure can be large-scale synthesized in AgNO3 (aqueous) at room temperature. The nonequilibrium and anisotropic growth at different silver ion concentrations result in controllable morphologies and morphological evolution. At high silver ion concentrations, a strong anisotropic growth contributes to a fine single crystalline silver dendrite. As the reaction proceeds, the dendritic structure transforms into a thermodynamically stable hexagonal structure. At a relatively low silver ion concentration, a particle-aggregated fractal pattern can be obtained due to relatively small anisotropy. As the reaction time increases, the transition from polycrystalline aggregates to a single crystal during silver dendritic growth can be observed. An oriented attachment mechanism can be used to explain the structural and morphological evolution of silver nanostructures. Silver nanostructures with various morphologies are expected to have significant potential applicat...


The direct current integrated charge method (DCIC- Q(t)) was used to diagnose an insulation behavior of a coaxial power-supply cable for motor driving under relatively low applied voltage by heating a part of the cable specimen. The Q(t) method is available to estimate the aging of the insulating layer of the cable. However, since a relatively high DC voltage must be applied to the insulating material of the cable in this method, it is difficult to apply it to the diagnosis of installed cables. Therefore, we attempted to measure the Q(t) by applying a relatively low DC voltage to the sample cable, which was partially heated. The results show that partial heating is effective in obtaining the Q(t) characteristics observed at room temperature under high DC voltages, even at relatively low DC voltages.


The paper presents the results of a calculation aimed to study the influence of ionizing, bremsstrahlung radiation on the operation of a nanosatellite obtained during the implementation of the project 0777-2020-0018 in 2020. A comparative analysis of the results of calculating the specific ionization and radiation energy losses of protons (from 0.1 to 400 MeV) and electrons (from 0.04 to 7 MeV), as well as their path lengths in aluminum according to the formulas of various authors and the database of materials of the National Institute of Standards and Technologies is presented. Based on the analysis results, the annual dose in the aluminum structure of the SamSat ION nanosatellite in a circular sun-synchronous orbit (SSO) is calculated. All calculations are based on the data of the energy spectra of protons and electrons of the SSO given in the Information system Spenvis of the European Space Agency. The results of calculating the integral fluxes in aluminum under the action of protons and electrons of a circular SSO for different thicknesses are obtained, and the fraction of passed particles is shown in the approximation of a single-layer stack. The radiation resistance of the electronic elements ISL70321SEH, ISL73321SEH and Virtex-4QV, Virtex-5QV included in the SamSat ION avionics and its ability to operate during a year was assessed.


The invention aims to provide a method and equipment for carrying out literary form conversion between vernacular Chinese and classical Chinese. The method comprises the following steps: obtaining vernacular Chinese input by a user; combining classical Chinese attribute information based on a translation model according to the vernacular Chinese, and converting the vernacular Chinese into classical Chinese corresponding to the vernacular Chinese; providing the classical Chinese for the user. Compared with the prior art, the requirements of carrying out the literary form conversion between the vernacular Chinese and the classical Chinese by the user are met and the use experience of the user is improved. Furthermore, according to the method and equipment, a classical Chinese literary form needing to be converted is selected by the user and the classical Chinese attribute information corresponding to the classical Chinese literary form is combined; the vernacular Chinese input by the user is converted into the corresponding classical Chinese; the use experience of the user is further improved.


Background: A 38-year-old man injured in a motor vehicle accident was admitted to the emergency department. At arrival, the patient showed signs of an acute abdomen and hypovolemic shock. An urgent explorative laparotomy was performed. A laceration of the gastroduodenal artery was found. Four days later, the patient complained of retrosternal pain and gave evidence of respiratory distress.


Three new prenylated xanthones, 1–3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D‐ and 2D‐NMR spectra, as well as HR‐MS experiments. Some of these compounds showed apoptotic effects or growth‐inhibition effects against HeLa cells expressing a caspase sensor protein.


By employing a generalized Riccati type transformation and the Taylor monomials, some new oscillation criteria for the even order functional dynamic equation ( r(t) ∣∣∣x∆n−1(t)∣∣∣α−1 x∆n−1(t))∆ + F(t, x(t), x(τ(t)), x∆(t), x∆(τ(t))) = 0, t ∈ [t0, ∞)T, are established. Several examples are also considered to illustrate the main results.


1/f noise in Hg0.7Cd0.3Te photodiodes has been measured as a function of temperature, junction area, diode voltage, and gate bias in order to identify the dominant noise mechanisms. The p‐n junctions were formed both by ion implantation and by growth of double‐layer epitaxial structures. The LPE base layers were doped with arsenic and the devices were passivated with photochemically deposited SiO2. Two leakage current mechanisms were identified as sources of 1/f noise. Under optimized surface potentials, the 1/f noise was proportional to the depletion‐region GR current generated at the surface. This was observed in both double‐layer devices in which the leakage current was primarily generated at the depletion‐region surface, and in ion‐implanted devices in which the leakage current had a bulk depletion‐region origin. For nonoptimized gate voltages, where tunneling currents were the dominant leakage mechanism, the noise current was proportional to the tunneling current. Surface, bulk, and photogenerated di...


Translation is one of the important fields of study in the literature and short story
is a part of literary work. The Short Story "The Object Of My Affection" is an
interesting story to be translated. The writer chose this Short Story because it has
not been translated into Indonesian. The purpose of this study is to translate the
English Short Story entitled "The Object Of My Affection" into Indonesian as
natural as possible as in the context of the source language. The writer found
some difficult words and used dictionary in translating the text.


The conceptual scheme of the mechanism of economic security management of a company has been suggested according to the previously developed approaches by the author. The article deals with the theoretical substantiation of principles and stages of complex assessment of effectiveness of the mechanism under study taking into consideration the increase of environmental treats during transfer technology development. In order to obtain more precise assessment of economic security management effectiveness it has been formed the methodological approaches to the assessment and its retrospective component makes it possible to characterize the economic security system in the comparable time and object area on the basis of an integral level dynamics. The second stage (optimization component of assessment) provides the determination of "safety factor" for the economic security system in a particular company on the basis of deflection of factual indices of economic security level from its rational level.


Sprawl. A Compact History. By Robert Bruegmann. University of Chicago Press, Chicago, 2005. 307 pp. $27.50, €17.50. ISBN 0-226-07690-3. Taking a contrarian position, the author argues that sprawl is a logical consequence of economic growth and democracy and that it offers people many benefits.


The role of nonlinear optical materials in applications such as optical switching, amplification, limiting etc. has resulted in a search for newer and efficient photonic materials. Phthalocyanine is one such material whose optical nonlinearity has not yet been studied completely. The versatility of phthalocyanine allows the tailoring of novel materials with enhanced optical nonlinearities. The nonlinear refractive index can be varied substantially by altering the 1I"-electron system as well as by substitution of the central metal atom. With this objective in mind, studies were conducted on the nonlinear optical properties of europium phthalocyanine as well as europium naphthalocyanine, In the present chapter optical limiting characteristics of europium naphthalocyanine under continuous wave laser irradiation were studied using different wavelengths of Ar+ laser.


Abstract Transactional analysis can be used to analyze personal interactions between consulting statisticians and their clients. The Parent-Adult-Child model has recently been refined to consist of six states by subdividing the Parent and Child ego states. The authors briefly define the six ego states (Nurturing Parent, Critical Parent, Adult, Adapted Child, Free Child, and Rebellious Child) and describe their occurrence during statistical consultations. Recommendations are given for identifying the ego states, setting realistic goals for relationships, and modifying unsatisfactory transactions.


Two kinds of cermet were prepared by vacuum sintering after die pressing. After being analyzed by differential thermogravity analysis(DTA), X-ray and scanning electron microscope(SEM), it is found that the form of adding metals has great effects on the microstructure and composition of ceramics. When Al is added as simple substance, the composition of ceramics is completely changed and a new spinal ferrite is formed. In the meantime, it led to nonuniform distribution of the elements in sample. When Al alloyed is added, the immigration of Al alloyed could be well controlled and the primitive ceramic isnt changed. The ceramic in two kind of cerments is unstable during sintering because the ceramic disassociates at elevated temperature.


The generalized likelihood-ratio test for zero-velocity detection provides a statistical motivation for commonly used zero-velocity detectors within inertial sensing. However, thus far, no equivalent statistical tests for other types of motions have been presented. Therefore, current activity and movement classifiers for inertial sensors typically rely on data-driven algorithms with features based on standard statistical measures. This letter studies the detection of rotations around a fixed axis using generalized likelihood-ratio tests. Two signal models are considered to describe such rotations. The first assumes a constant angular velocity and the second assumes a constant rotation direction. The resulting detection statistics are derived as the sample variance of the gyroscope measurements and the smallest eigenvalue of a positive semidefinite matrix that is proportional to the square of the gyroscope measurements over the detection interval. Experimental results support the use of the constant rotation direction model, thereby highlighting the need for a signal model that is more general than the constant angular velocity model.


Araceae is a large family consisting Aroids or Arums. It is a monocot plants characterized by the inflorescence, consisting a spadix subtending a spath. The aim of the study was to determine the relationship of 13 species from seven genera of Araceae using phenetic approach. The seven genera are Anthurium, Spathyphyllum, Monstera, Philodendron, Syngonium, Alocasia and Caladium. A cluster analysis was performed using the Multivariate Statistical Procedures Version 2.2 (MVSP) on 22 macro morphological characters of the species studied.  There are three constant clustered groups in Araceae studied based on similarity in morphological; (1) Anthurium forgetii and A. leuconeurum, (2) M. oblique expilata, P. scandens oxycardium and Monstera sp. 1 and, (3) M. deliciosa, P. scandens and Philodendron sp. 1. The cluster analysis indicates Caladium sp. No. 1 had the lowest similarities (5.6%) compared to other 12 species. Meanwhile, M. deliciosa and P. scandens exhibit the highest similarity (68.4%) for both analyses.


Ultrarelativistic heavy ion beams carry large electromagnetic and strong absorptive fields, allowing exploration of a variety of physics. γγ, γP, and PP interactions can probe a huge variety of couplings and final states. RHIC will be the first heavy ion accelerator energetic enough to produce hadronic final states via coherent couplings. Virtual photons from the nuclear EM fields can interact in γγ interactions, which can be exploited to study many particle spectroscopy and QCD topics. Because the photon flux scales as Z2, γγ luminosities are large up to an energy of about γℏc/R≈3 GeV/c. Photon-Pomeron interactions are sensitive to how different vector mesons, including the J/ψ, interact with nuclear matter. PP collisions rates are sensitive to the range of the Pomeron. Signals can be separated from backgrounds by using cuts on final state isolation (rapidity gaps) and p⊥. We present Monte Carlo studies of different backgrounds, showing that representative signals can be extracted with good rates and sig...


Ovarian cancer remains a major public health issue due to its poor prognosis. To develop more effective therapies, it is crucial to set-up reliable models that closely mimic the complexity of the ovarian tumor's microenvironment. 3D bioprinting is currently a promising approach to build heterogenous and reproducible cancer models with controlled shape and architecture. However, this technology is still poorly investigated to model ovarian tumors. In this study, we describe a 3D bioprinted ovarian tumor model combining cancer cells (SKOV-3) and cancer associated fibroblasts (CAFs). The resulting tumor models showed their ability to maintain cell viability and proliferation. Cells were observed to self-assemble in heterotypic aggregates. Moreover, CAFs were observed to be recruited and to circle cancer cells reproducing an in vivo process taking place in the tumor microenvironment (TME). Interestingly, this approach also showed its ability to rapidly generate a high number of reproducible tumor models that could be subjected to usual characterizations (cell viability and metabolic activity; histology and immunological studies; and real-time imaging). Therefore, these ovarian tumor models can be an interesting tool for high throughput drug screening applications. This article is protected by copyright. All rights reserved.


There has been much work recently on improving the locality performance of loop nests in scientific programs through the use of loop as well as data layout optimizations. However, little attention has been paid to the problem of optimizing locality in whole programs, particularly in the presence of procedures. Current techniques do not propagate layout optimizations across procedures boundaries; this is critical for realistic scientific codes, since the cost of explicitly transforming memory layouts across procedure boundaries might be very high. In this paper we present a locality optimization framework that uses both loop and data transformations to improve cache locality program-wide. Our framework propagates layout (or locality) constraints as a system of equalities across procedures and involves two traversals in the call graph representation of the program. Preliminary experimental results obtained on an R10000 based system demonstrate the power of the framework.


This study was envisaged to explore the impact of pesticide solid waste leachate to Allium cepa (common onion) bulbs. Bulbs exposed to the leachate showed hampered root growth and morphological deformities. At 15% and higher concentrations of leachate after 5 days, gall like swellings were noticed around the mitotic zone (zone of root growth). From the dose response curve, the EC50 values for the 5 th , 10 th , 15 th and 20 th day were calculated and the highest EC50 value, 24.9%, was for the 5th day while the lowest EC 50 value, 20%, was for the 20th day. The EC 50 decreases from 5 th to the 20 th day successively. The 5 th day EC50 was used to determine the hazard quotient (HQ) of the pesticide waste leachate from the dumping site. A value of 4.49 as HQ suggests that that there is considerable risk, as any value of HQ above one (>1) is environmentally unacceptable. The response in root growth pattern, residue analysis and the HQ indicates that the leachate is toxic to rot growth of onion and steps for proper management of hazardous waste and leachate are urgently required.


To examine the relationship between apparent diffusion coefficients (ADC) from diffusion weighted imaging (DWI) and choline levels from proton magnetic resonance spectroscopic imaging (MRSI) in newly diagnosed Grade II and IV gliomas within distinct anatomic regions.


The computer vision community has made tremendous progress in solving a variety of semantic image understanding tasks, such as classification and segmentation. With the advancement of imaging technology and hardware, image semantic segmentation, through the use of deep learning, is among the most common topics which have been worked on in the last decade. However, image semantic segmentation suffers from several drawbacks such as insufficient detection of object boundaries. In this study, we present a new convolutional neural network architecture called CSU-Net that aims to self-enhance the results of semantic segmentation. The proposed model consists of two strongly concatenated encoder-decoder blocks. With this design, we reduced requirements on computing power and memory size to decrease costs and increase the training/prediction speed. This study also demonstrates the advantage of the proposed system for small training data sets. The proposed approach has been implemented on our private dataset, as well as on a publicly available dataset. A comparative analysis was carried out with four popular segmentation models and three other recently introduced architectures to show the efficiency of the proposed system. CSU-Net outperformed the other competing neural networks that we considered for the comparative study. As an example, it succeeded in improving the traditional U-Net result by approximately 50% in mean Intersection over Union (mIoU) for both tested datasets. Based on our experience, the CSU-Net can improve results of semantic segmentation in many applications.


We present results from numerical simulations of the current collapse phenomenon in GaN heterostructure field effect transistors. Gate lag simulation results show that current collapse can be explained by an enhanced trapping under the gate edges. Hot electrons play an instrumental role in the collapse mechanism. The simulation results also linked collapse with electrons spreading into the substrate, and confirmed that better electron localization, as in a double heterostructure field effect transistor, can dramatically reduce current collapse.


The present invention is especially new preparation process of xylose. The preparation process includes the following successive steps: 1) cleaning material, soaking in pure a, heating, regulating pH to 7 and filtering to obtain filter cake; 2) hydrolysis via adding sulfuric acid in 5 times at 90-100 deg.c and filtering to obtain filter cake; 3) decolorizing with active carbon and retaining clear filtrate; 4) neutralizing with calcium carbonate to pH 3-4 and retaining filtrate; 5) ion exchange in the cation exchange flow rate of 65-85 ml/min and anion exchange flow rate of 100-150 ml/min; 6) concentration to 10-15 % of initial volume; and 7) crystallization via adding alcohol. The said preparation process is simple and feasible, and the prepared xylose has high purity.