Abstract A 20-channel grating polychromator transferred from Princeton Plasma Physics Laboratory has been rebuilt for electron cyclotron emission measurements on EAST. This instrument measures the second-harmonic electron cyclotron emission from plasma with frequency range from 90 to 250 GHz, which corresponds to a central magnetic field (R0 = 1.7 m) of 2 to 3.5 T on EAST. The radial resolution of this instrument is [approximately]2.5 cm, and the poloidal spot size of the quasi-optic antenna is [approximately]3 cm. New preamplifiers are made and tested, based on the electronics of GPC-II on TFTR. These amplifiers have a gain of around 520, with a 400-kHz, 3-dB rolloff. Measurement results from the 2010 EAST experimental campaign show that the intensity of this instrument is [approximately]200 mV for electron temperature of 850 eV, and the signal-to-noise ratio is [approximately]20.


The paper advances a new method for optimizing the organization structure—genome method,which is aimed at the limitations of traditional project management and is based on hereditary program management knowledge. The paper presses the precondition and the enforcement step in a systematic way. It creates a new thought for heighten the management level and make innovations in the program management methods.


This article tests 2 competing explanations for the truth effect, the finding that repeated statements are believed more than new statements. Previous research has put forth 2 explanations for this effect—subjective familiarity and perceived source variability. The subjective familiarity explanation holds that repeated statements feel more familiar and are therefore believed more than new statements. This explanation has received strong support in the literature. The source variability explanation holds that people attribute repeated statements to different sources; this belief, that multiple sources endorse the statement, increases belief in repeated statements relative to new statements attributed to a single source. However, previous studies testing this explanation have confounded source variability with source credibility. This research aims to tease apart the effects of subjective familiarity and source variability while holding source credibility constant across conditions. Results of the first 2 experiments manipulating number of sources and measuring recognition implicate subjective familiarity rather than perceived source variability as the mechanism underlying the truth effect. However, the third study demonstrates that source variability does enhance belief in repeated statements that are initially perceived as low in plausibility. Theoretical and practical implications are discussed. You are flipping through a magazine and see an ad for Take Control, a spread made from natural soybean extract. The ad says "Take Control tastes great and helps promote healthy cholesterol levels!" Do you believe it? What if you then see a picture of Regis Philbin with his testimonial "Sounds too good to be true? Wait 'til you try it. It's delicious and helps me look after my cholesterol!" —will his testimonial increase your belief? Without product experience, you may be forced to depend on cues (such as how familiar the claim feels or how many


The relaxing of censorship in Britain at the turn of the eighteenth-century led to an explosion of satires, caricatures, and comic hoaxes. This new vogue for ridicule unleashed moral panic and prompted warnings that it would corrupt public debate. But ridicule also had vocal defenders who saw it as a means to expose hypocrisy, unsettle the arrogant, and deflate the powerful. This book examines how leading thinkers of the period searched for a humane form of ridicule, one that served the causes of religious toleration, the abolition of the slave trade, and the dismantling of patriarchal power. It brings to life a tumultuous age in which the place of ridicule in public life was subjected to unparalleled scrutiny. It shows how the Third Earl of Shaftesbury, far from accepting ridicule as an unfortunate byproduct of free public debate, refashioned it into a check on pretension and authority. The book examines how David Hume, Mary Wollstonecraft, and others who came after Shaftesbury debated the value of ridicule in the fight against intolerance, fanaticism, and hubris. Casting Enlightenment Britain in an entirely new light, the book demonstrates how the Age of Reason was also an Age of Ridicule, and speaks to our current anxieties about the lack of civility in public debate.


This presentation is aimed to stimulate discussion among professionals about the continuation of the author's own designed concept of the InZu Model, which supports the assessment of corporate innovativeness in the insurance sector. The following proposal comes as the next step in the work on the development of the InZu Model and refers to the necessity for the creation of a model concept of an innovative insurance company as well as the methodology and application in comparisons and assessments to be conducted in this corporate sector in the future. Being aware of the necessity for assessment of innovativeness in the insurance sector, the authors began their conceptual work on the InZu Model in search of those aspects and areas of operation of an insurance company which, if managed innovatively, may finally give rise to the customer oriented reductions in prices of the offered insurance products. Thus, to a large extent, the holistic context of the InZu Model construction results from an aspiration to diagnose and promote the socially advantageous function of innovations pursued in the sector of insurance.


e20724 Background: Anemia is common in patients receiving chemotherapy and may adversely affect health-related quality of life. Erthyrpiotic factors darbepoetin alfa (DA) and epoetin alfa (EA) are currently approved for the treatment of anemia in patients with nonmyeloid malignancies who receive chemotherapy.

METHODS
Forty patients with a diagnosis of nonmyeloid malignancy with 8 weeks of planned chemotherapy, age 18 years, and anemia (hemoglobin 10 g/dL). 20 patients received DA 500 μg every three weeks (Q3W) and the others 20 patients received EA 40,000 units every week (QW) for up to 18 weeks. Treatment was hold at week 6 for nonresponse, which was defined as failure to achieve a hemoglobin increment of at least 2 g/dL above the baseline measurement. Efficacy was assessed by the incidence of RBC transfusion.

RESULTS
Forty patients with a diagnosis of nonmyeloid malignancy, the median age was 49 years and 52 years for DA and EA groups respectively, The majority of patients had solid tumors: Common cancer types for (DA - EA) groups were gastrointestinal (8 -5), breast (3-6), lung (3-3), soft tissue sarcoma (2-1), genitourinary (2-1), non-Hodgkin's lymphoma (1-1), multiple myeloma (1-1), Hodgkin's lymphoma (0-1), and metastatic with unknown primary in (1-0) respectively . 75% 0f the patients in both group achieved the target hemoglobin level. Transfusion incidence from week 6 to the end of the treatment phase (the primary end point) was required in 5 patients (25%) in both groups. The side effects reported in this study were thromboembolic in two patients in both groups 10%. Nausea, diarrhea and neutropnia were 25%, 15% and 10% for DA group respectively compare to 20%, 10%, and 15% in AE group respectively.

CONCLUSIONS
This study demonstrates comparable efficacy and safety of DA 500 μg every three weeks (Q3W) and EA40, 000 units every week (QW). No significant financial relationships to disclose.


Three-dimensional (3D) multi-modality medical bone image registration is an important technology in surgical application, especially in large computer-aided orthopedic surgery. To improve registration accuracy, we propose a new 3D multi-modality medical bone image registration algorithm based on local features through analyzing the bone structure. In this method, the image Hessian matrix is introduced for local features extraction, and the local behavior of the 3D bone image is described by the eigenvalues of Hessian matrix. This method can automatically extract and select the most representative feature points (blob-like structure) in different scales. Then we adopt the idea of triangle matching to get stereo matching point pairs. Improve random sample consensus (RANSAC) algorithm is adopted to remove wrong matching point pairs. We use the right matching point pairs to establish rigid transformation model and solve this non-linear model by Levenberg-Marquardt algorithm to get geometric transformation parameters. Simulated experiments and real experiments demonstrate that the proposed method can achieve a high image registration accuracy.


The invention discloses a management data reading and writing method and device. The management data reading and writing method comprises the steps that when I/O requests of a data block are available, the total number of the I/O requests of the data block is determined, whether the total number of the I/O requests of the data block exceeds the preset counting threshold value or not is judged, and the heat grade value of the data block is determined when the total number of the I/O requests of the data block exceeds the preset counting threshold value; the determined heat grade value of the data block is compared with the preset heat grade value threshold value, and whether the storage position of the data block in the preset corresponding relation is updated or not is determined according to the comparison result; I/O operation of the data block is conducted according to the updated storage position of the data block in the preset corresponding relation. According to the technical scheme, the overall performance of a storage system is improved.


the appropriate treatment of bipolar symptoms can contribute to improve mood, behaviour, and cognition in both bipolar type pseudomentia and dementia with secondary mood instability. However, if drugs targeting dementia may also be useful in the latter, they have no action on the former or could even aggravate the clinical picture. Further research could contribute to better disentangle the effects of treatment on the mood symptoms and cognitive dysfunction encountered in this illness.


The objective of the topic is to review the recent trends in corrosion inhibitors for rein- forced concrete and their application in the laboratory and field conditions. Inhibitors are chemical substances which when added to the concrete in small concentrations will inhibit or prolong the time to initiation of corrosion in concrete structures. This chapter focuses on the type of inhibitors used in concrete based upon their mode of action and the way of application. The section deals with anodic, cathodic, mixed inhibitors; perfor mance of admixed inhibitor vs. migrating/surface applied inhibitor and their evaluation studies; and electrochemical injection of corrosion inhibitor (EICI) in concrete and elec trochemical chloride extraction techniques has been reviewed.


Virginia Euwer Wolff 6\ T \ / OUNG-adult literature is literature read by young \X people in approximately grades 7 through 12. j-i I Unlike other publishing movements, young-adult \g^ literature in the United States became a phenomenon in almost a single year, 1967, when writers and publishers of materials for teenagers reached beyond the simple plots and white, middle-class protagonists of the postWorld War II era and presented the more culturally diverse and socially complex environment of the 1960s. Three groundbreaking novels published expressly for the young-adult audience in 1967 were S. E. Hinton's The Outsiders, Ann Head's Mr. and Mrs. Bo Jo Jones, and Robert Lipsyte's The Contender. Among generalized characteristics of these and subsequent contemporary realistic young-adult novels are their varied subjects and often fast-paced narratives about independent and accomplishing protagonists who are presented from the point of view of a young person addressing emotions shared by young adult readers. These characteristics, emphasizing the needs and interests of young adults, appealed to the readership of the day. Since 1967, young-adult authors across many genres have created an enduring and respected body of literature that young adults have chosen to read. Any reader, young or old, may enjoy the best of young-adult literature by selecting from the wide range of works by ten outstanding U.S. authors: Robert Cormier, Paul Fleischman, Russell Freedman, Lois Lowry, Robin McKinley, Walter Dean Myers, Katherine Paterson, Gary Paulsen, Richard Peck, and Virginia Euwer Wolff. These ten have produced works that appeal emotionally to young people at their developmental levels and offer them opportunities to read with understanding and literary appreciation. As a group, their combined works represent the broad scope of youngadult literature, including the genres of poetry, contemporary realistic fiction, fantasy, science fiction, historical fiction, biography, and information books. More important, however, authorities in the field have recognized these authors. For example, Alleen Pace Nilsen and Kenneth Donelson have included the nine who are fiction writers in their honor list, a standard feature in their classic textbook, Literature


This paper deals with study of the effect of input voltage variation on output response of bio-impedance measurement. During bio-impedance diagnosis output voltage differs as a function of function of input signal voltage variation. The accuracy of the diagnosis system depends on the exact value of voltage for which there is a wide variation in the output response. The proposed system implements voltage control signal generator circuit to study the output voltage variation and its impact on efficient design of invasive bio-impedance measurement applications. The system design has been implemented variable voltage signal generator IC, Isolation transformer, isolated & regulated power supply, Operational amplifier IC and Metal Surface electrodes. Introduction: In non invasive electrical bio-impedance measurement applications the measuring parameter depends on input signal frequency and input voltage level. The electrical property of the biological tissue alters as a function of input voltage variation. The property of electrical conductivity change as a function of input voltage has been utilized in wide field of bio-impedance systems [1 & 2]. Few examples are in non invasive cardiac output monitoring, dialysis and measurement of blood volume in human body [3 & 4]. The proposed variable voltage signal generator circuit which suits for non invasive bio-impedance measurement applications. The signal from signal from the designed signal generator has been given to the two electrodes and the voltage response values are noted [5]. Materials and methodologies: Four metal surface electrodes are used for achieving non invasive bio-impedance system. Out of four electrodes two for input section and two for output section. In input section IC 8038, a precision waveform generator capable to produce sine wave, square wave and triangular wave with frequency variation from 0 Hz to 200 KHz and variable voltage with few additional components. With the provision of external potentiometer circuit the output amplitude can be varied from low voltage to high voltage. These IC generally used for Precision waveform generator, Sweep and FM Generator, Tone Generation, Instrumentation and Test Equipment design and Precision PLL design. It is a 14 pin IC with three output pin for Sine wave output, Square wave output and Triangular wave output. Two pins for adjusting waveform on input side, two pins for control the duty cycle on input side and two pins for frequency modulation and frequency sweep input. The circuit for proposed system implements signal generator circuit which suits for non invasive bio-impedance measurement applications [5 & 6]. Hardware section of the system composed of variable voltage signal generator IC, Isolation transformer, Regulated and isolated power supply, Operational amplifier IC and four Surface electrodes as shown in figure 1. Figure 1. Generalized input variable voltage signal generation system block diagram The study has been done with 10 individuals for obtaining the value of voltage for which there was good response in output voltage value. Four constant voltage values are selected within the range from 1 Volt to 8 Volts and its corresponding response were tabulated and plotted as graph. The input voltage values V1=1 Volt, V1=3 Volt, V1=6 Volt and V1=8 Volt. Out of 10 individual each individuals are placed with four surface electrodes. The signal from the designed signal generator has been given to the two electrodes and the voltage response values are noted. Results and Discussion: The output voltage values varies from 0.14 V to 0.45 V for input voltage V1=1 Volt, the output voltage values varies from 0.25 V to 0.60 V for input voltage V2=3 Volt, output voltage values varies from 1 V to 2.5 V for input voltage V3=6 Volt as shown in table 1 and output voltage values varies from 1.8 V to 4.30 V for input voltage V1=8 Volt. Table 1. Output voltage variation range for different input voltage levels INPUT VOLTAGES V1=1Volt V2=3Volt V3=6Volt V4=8Volt OUTPUT VOLTAGE VARIATIONS 0.14 V to


This paper presents a novel alternative approach, namely weakly supervised learning (WSL), to learn the pre-image of a feature vector in the feature space induced by a kernel. It is known that the exact pre-image may typically seldom exist, since the input space and the feature space are not isomorphic in general, and an approximate solution is required in past. The proposed WSL, however, would find an appropriate rather than only a purely approximate solution. WSL is able to involve some weakly supervised prior knowledge into the study of pre-image. The prior knowledge is weak and no class label of the sample is required, providing only information of positive class and negative class which should properly depend on applications. The proposed algorithm is demonstrated on kernel principal component analysis (KPCA) with application to illumination normalization and image denoising on faces. Evaluations of the performance of the proposed algorithm show notable improvement as comparing with some well-known existing approaches


A series of s-triazoles and thiohydantoines were synthesized by dehydrocyclization of 1-substituted-4-ethoxycarbonylmethylthiosemicarbazides. The molecular structure proposed for s-triazoles was confirmed by the X-ray crystal structure analysis of one compound that was prone to crystallization. All compounds were tested in vitro for their antibacterial activity. Some of them showed low levels of activity against Gram-positive species, MIC range 100–400 μg/mL or higher. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:131–138, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20597


Accounting computerization develops the accounting file's application and service functions, forms and measures, and as for the accounting file administrative staff's quality, the management of it and the secure application some new requests are put forward. Thus, some active countermeasures must be adopted.


Now a days, Laparoscopic repair is the preferred method for repair of
inguinal hernia owing to its safety and reliability. Use of meshes has
been adopted as standard procedure in surgery. 1
hernia repair
Laparoscopic approach which involves closure of hernia with mesh
2
placement is associated with reduced chronic postoperative pain and
numbness, fast return to normal activities, and decreased incidence of
3 hematoma and wound infection. Two approaches to perform
laparoscopic repair include Transabdominal Preperitoneal (TAPP)
2
approach and the Totally Extraperitoneal (TEP) approach


Experimental and numerical investigations of a magnetic ponderomotive force acting on non-magnetic body immersed in ferrofluid were carried out. The study was performed on a nonmagnetic sphere in a cylindrical container filled with the magnetic fluid and magnetized by a uniform magnetic field. The symmetry of the experimental setup allowed the simplification of the problem: 2D axisymmetric numerical simulation corresponded to the 1D experimental measurements. The magnetic ponderomotive force turned out to be non-monotonic: it has two extrema and one or three zero values depending on the geometrical parameters of the container and magnitude of the applied field intensity. It was shown that wall effects are crucial for this problem, because the ponderomotive force in the vicinity of the container's bottom (or top) may change its sign (direction). This behaviour can be described only in the framework of the inductive approach, which takes into account all demagnetizing fields generated by the ferrofluid container. On the contrary, the simplified non-inductive approach is unable to explain the magnetic force behaviour, especially the wall effects.


Abstract The electric field at the interface between the n+-layer and the central i-region has been used to describe the injection properties of the electrode, i.e. the injecting junction region, of n+-i-n+ devices of hydrogenated amorphous silicon. The effect of this field on the determination of the density of states (DOS) in amorphous silicon from space-charge-limited-current (SCLC) measurements has been investigated. It is shown that the electrode has little effect on the deduced DOS values for reasonable interface field and it is concluded that SCLC measurements on a-Si:H are representative of a bulk property of the material.


The Intensive Adult Psychiatric Rehabilitation Program of the Central Highlands (APROTCH) is a psycho-social rehabilitation program which aims to address the needs of young adults who have recently experienced the onset of serious mental illness. The program was developed in 1996 in consultation with the Early Psychosis Prevention and Intervention Centre (EPPIC) Victorian statewide services, in response to a significant change in the characteristics of referrals received.


Failure of highway pavement and collapse of building in basement complex of Nigeria is often related to the instability of the residual. This study evaluated the strength characteristics of gneiss-derived residual Soils as materials usable for road pavement structures. A total of eleven soil samples derived from granite gneiss were subjected to laboratory geotechnical analyses based on standard practices. The geotechnical analyses reveal the soils' natural moisture content, specific gravity, grain sizes, consistency limits, shearing strengths, maximum dry density, and optimum moisture content. Based on AASHTO classification, the soil samples are classified as A-7-6, A-6, and A-7-5. The results of the laboratory analyses revealed that the natural moisture content and specific gravity ranged from 8.30 to 22.70% and 2.6 to 2.8 respectively. Particle size analysis reveals that the coarse contents of the soils ranged from 28.8% to 59.8% and amount of fines ranged from 40.2 to 71.2%. The liquid limit ranged from 31.3% to 68.3%, plastic limit ranged from 20% to 28.0%, plasticity index ranged from 4.8% to 38.90% and linear shrinkage ranged from 5.7 to 13.6%. The maximum dry density ranged from 1481 kg/m3 to 1921 kg/m3 and optimum moisture content ranged from 15.2% to 27.6%. Undrained triaxial shear strength (Cu) ranged from 43.0 Kpa to 250.3Kpa, angle of friction ranges from 11.7 to 29.30, and unconfined compressive strength ranged from 153 to 356.5Kpa. The results indicate that the residual soils are poor sub-grade and foundation materials due to their high amount of fines, linear shrinkage values, plasticity, and swelling potential, as well as low maximum dry density.


An interview with a neurologist who found that merely writing medical articles cannot express the impact an illness can have on patients, both literally and emotionally.


For screening of biological activities of culture broth of some wood rotting basidiomycetes, antimicrobial activity, plant growth regulating activity, antitumor activity, and various enzyme activities were checked. Coriolus versicolor 5129 and C. pubescens 5131 strains showed inhibition activity against gram-positive bacteria and Lenzites betulina 8029 strain showed the activity against gram-negative bacteria. L. betulina 8085 inhibited the growth of both bacteria and plant pathogenic fungi. All of tested basidiomycetes inhibited the germination and growth of radish and cabbage at concentration of 0.8ml/ml. Especially, Fomitopsis pinicolor 8059 and Fomitella fraxinea 8084 showed strong inhibition activity. In contrast, Bjerkandera adusta 8054 stimulated the growth of cabbage and radish at concentration of 0.4 and 0.2ml/ml. All polysaccharides from tested basidiomycetes showed anti-tumor activity against sarcoma 180 and the stronger antitumor activity was observed in L. betulina 8029 and unidentified 8058 strain. All tested basidiomycetes had also an ability to degrade cellulose and lignin.


Electron irradiation of 100% internal quantum efficiency silicon photodiodes having a thin (60 /spl Aring/) SiO/sub 2/ dead layer results in measured responsivities ranging from 0.056 A/W at an incident electron energy E/sub 0/=0.2 keV to 0.24 A/W at E/sub 0/=40 keV. A theoretical electron-hole pair creation energy of 3.71 eV, in close agreement with other studies, is derived using a Monte Carlo simulation of electron interactions with the photodiode over an energy range of 1 to 40 keV. Analysis of electron energy lost to processes that do not contribute to electron-hole pair creation shows that the energy lost in the SiO/sub 2/ dead layer is dominant for E/sub 0/<1.5 keV, whereas the energy removed by backscattered electrons is dominant for E/sub 0/>1.5 keV. At E/sub 0/=300 eV, the Monte Carlo simulation results show that the electron projected range is significantly less than the dead layer thickness even though the measured response is 0.082 A/W, indicating that electron-hole pairs generated in the oxide dead layer are collected by the junction.


As demonstrated by the example of (section) 24aStVG, the repeated tightening of the law in a relatively short space of time is, unfortunately, not the exception to the rule these days. With legislatory eagerness, legally normed restrictions are tightened further, allowing no probation period for the legal position as it is known to date. This 'does only quantity matter' practice causes concern, in particular with regard to the obviously secondary importance of the principle of proportionality and the principle 'in dubio pro libertate'. In addition there is the danger of a ban losing its acceptance as a result of the tightening being taken too far. This may result in the person affected being punished just to set a "political precedent" for a third party. Therefore the populist pressure for the increase of the penalty should be countered with more restrained measures.


the observed difference in proportions cured between the treatment and control groups without considering the difference in patient characteristics in the population at these two (interim and final) stages, the resulting estimate may not reflect the estimand. This is because the estimate of the unobserved population quantity is obtained from a population that does not reflect the patients randomized. Similarly, if study adaptation Abstract Adaptive designs allow prospectively planned modifications of a study without undermining the integrity and validity of the study. The draft ICH E9 addendum recommends the estimand framework in design, conduct, analysis, and interpretation of clinical trials for assessment of effectiveness of therapies. Herein, we discuss the possible impact and scientific implications when incorporating the estimand framework to adaptively designed clinical trials. It is hoped that this will elucidate how this framework provides a language for discussing relevant questions, related to the attributes of the estimand, that may arise from study adaptations.


Attentional capture is a phenomenon in which rewarded stimuli become more salient, automatically drawing attention when encountered later. Attentional capture can be reliably produced in the laboratory, usually by paying participants money for finding certain targets in a visual search task (Anderson, Laurent, & Yantis, 2011). We have recently shown that attentional capture can also be produced by presenting tasks in a videogame-like format, with points and sound effects serving as the rewards in place of money (Miranda & Palmer, 2014). In the current study, we apply gamified attentional capture training to the automatic processing of target shapes rather than target colors. Participants were rewarded for locating certain shapes in a training phase and then in a later test phase (during which shape was irrelevant to the task) participants were significantly slower to identify oddball color targets if a previously rewarded shape was present as a distractor. This demonstrates that participants' visual systems learned to prioritize processing of rewarded shapes and automatically attend to them even when they were irrelevant to the task. Implications of this work for training of socially critical visual search tasks is discussed.


A questionnaire survey of the opinions of major employers of Electrical Engineering graduates concerning the relevance to their needs of undergraduate courses in this discipline, in the University of Salford, has been conducted. The generally poor response does not allow detailed comparisons to be made, but a few of the more important consensus views concerning the style of courses and the qualities of graduates are summarized.


The Pecos Valley News was a newspaper for the community of Artesia, New Mexico located in Eddy County. The newspaper dates back to 1906, and it was published until 1917.


Chronic low-grade inflammation in adipose tissue often accompanies obesity, leading to insulin resistance and increasing the risk for metabolic diseases. MAP3K8 (TPL2/COT) is an important signal transductor and activator of pro-inflammatory pathways that has been linked to obesity-induced adipose tissue inflammation. We used human adipose tissue biopsies to study the relationship of MAP3K8 expression with markers of obesity and expression of pro-inflammatory cytokines (IL-1b, IL-6 and IL-8). Moreover, we evaluated obesity-induced adipose tissue inflammation and insulin resistance in mice lacking MAP3K8 and WT mice on a high-fat diet (HFD) for 16 weeks. Individuals with a BMI .30 displayed a higher mRNA expression of MAP3K8 in adipose tissue compared to individuals with a normal BMI. Additionally, high mRNA expression levels of IL-1b, IL-6 and IL-8, but not TNF -a, in human adipose tissue were associated with higher expression of MAP3K8. Moreover, high plasma SAA and CRP did not associate with increased MAP3K8 expression in adipose tissue. Similarly, no association was found for MAP3K8 expression with plasma insulin or glucose levels. Mice lacking MAP3K8 had similar bodyweight gain as WT mice, yet displayed lower mRNA expression levels of IL-1b, IL-6 and CXCL1 in adipose tissue in response to the HFD as compared to WT animals. However, MAP3K8 deficient mice were not protected against HFDinduced adipose tissue macrophage infiltration or the development of insulin resistance. Together, the data in both human and mouse show that MAP3K8 is involved in local adipose tissue inflammation, specifically for IL-1b and its responsive cytokines IL-6 and IL-8, but does not seem to have systemic effects on insulin resistance. Citation: Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, et al. (2014) MAP3K8 (TPL2/COT) Affects Obesity-Induced Adipose Tissue Inflammation without Systemic Effects in Humans and in Mice. PLoS ONE 9(2): e89615. doi:10.1371/journal.pone.0089615 Editor: Yan Chen, Institute for Nutritional Sciences, China Received June 26, 2013; Accepted January 24, 2014; Published February 24, 2014 Copyright: 2014 Ballak et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. MGN was supported by a Vici grant of the Netherlands Organization for Scientific Research. RS was supported by a Ruby Grant of the Dutch Diabetes Research Foundation. Competing Interests: One of the authors is an employee of the Novartis Pharma AG, Basel, Switzerland. However, neither he or the company have any competing interests in this study. Additionally, no patents or marketing products have been used in the current study, nor will the company benefit from the results reported in this manuscript. Helmut Sparrer has provided the authors with the unique MAP3K-deficient mouse model. and contributed to writing and revising of the manuscript. Novartis does not conduct any research on MAP3K and has no intellectual or financial interests. Therefore, the authors herby confirm that this does not alter adherence to all the PLOS ONE policies on sharing data and materials. * E-mail: firstname.lastname@example.com . These authors contributed equally to this work. " These authors share senior authorship.


Introduction: According to international guidelines the vaccination schedule for hematological patients is mainly recommended prior to treatment start, three to six months after chemotherapy and following both allogeneic and autologous transplantation due to weakened immune response with variable response ef fi cacy. As for Severe Acute Respiratory Syn-drome Coronavirus risk of in patients with hematological malignancies


doi: 10.12957/geouerj.2016.14415 San Jose, Costa Rica is undergoing significant changes related to the technical innovation in the area of construction, changes in legislation and the imposition of a new way of living. The intensification of urbanization led to the fast residential verticalization in strategic points of the Gran Area Metropolitana. This article presents the recent trends in the housing market, highlighting key factors that contribute and limit the local real estate development. It is also analysed the different agents and financing methods involved in the housing sector. It is discussed the differences between use value and exchange value of these recent residential projects and how location influences this differences.


GAUSS will be provided by Germany as a contribution to LUNARSTAR Mission in the NASA Discovery program. The main scientific objectives of the LUNASTAR mission are the exploration of a lunar atmosphere, the study of lunar geochemistry and the surface evolution of the Moon In connection with a determination of the total gravity field with high resolution (typically 70 - 70), considerable new insight will be gained in the following areas: Global shape model of the Moon, near/far-side dichotomy, structure and evolution of large impact craters and basins, evolution of the lithosphere, comparative planetology. It is proposed to provide a subsatellite with a total mass of ~ 16 kg dedicated only to gravity field determination. GAUSS shall relay phase coherent microwave signals (S-band) from LUNARSTAR to Earth with an overall Doppler accuracy of better than 1 mm/s. The frequency source (USO) onboard the Lunastar main spacecraft. From the Doppler data collected at the German and US groundstations both local and global gravity information will be derived. The time duration for the gravimetry mapping part of the LUNARSTAR has reached its 100 km altitude polar circular orbit. GAUSS will remain in the eccentric polar lunar transfer orbit (200 km - 5000 km). Launch is forseen in October 2001.


This paper analyzes 621 videos published during two weeks on the front pages or covers of five Spanish digital newspapers ( abc.es , elconfidencial.com , elmundo.es , elpais.com and lavanguardia.com ). The contents, genres, formats and structures of these videos have important singularities –both own and external production– in regard to the typical audiovisual production of television news. In addition to data from fieldwork, this study provides the ideas from audiovisual department heads about the role of video in digital media.


The article proposes that social media platforms enable large volumes of user-driven circulation of media content, and argues for a combination of qualitative and quantitative considerations when a ...


The threat of biological warfare and the emergence of new infectious agents spreading at a global scale have highlighted the need for major enhancements to the public health infrastructure. Effective confrontation of these urgent crises requires rapid and accurate detection of unusual epidemiologic trends, for which our current surveillance capabilities are not adequate. Critical for real time surveillance are two components: real-time data and real-time interpretation of data. Today, most existing surveillance systems are capable of monitoring and capturing real time data. However, the state of practice for detecting temporal and spatial abnormalities in surveillance data remains inadequate. We introduce a locally stationary binomial model of early detection of epidemiologic events, applied to real historical data pertaining to the daily number of visits with respiratory syndromes to the emergency department (ED). We show that when simulated outbreaks are introduced into the respiratory data, our uniformly most powerful detection algorithm under a constant false alarm rate is capable of detecting such irregularities in the data with high sensitivity, specificity, and in a timely manner.


Although small in number, massive stars are critical to the formation and evolution of galaxies. They shape the interstellar medium of galaxies through their strong winds and ultra-violet radiation, are a major source of the heavy elements enriching the interstellar medium, and are the progenitors of core-collapse supernovae and gamma-ray bursts, which are among the most energetic explosions in the Universe and mark the death of a massive star. Still, our understanding of the connection between massive stars and supernovae from observations is fairly limited. In this dissertation, I present new observational evidence that shows the importance of metallicity, mass-loss, and binarity in the lives and deaths of massive stars. We investigate how the different types of supernovae are relatively affected by the metallicity of their host galaxy. We take advantage of the large number of spectra of star-forming galaxies obtained by the Sloan Digital Sky Survey and their overlap with supernova host galaxies. We find strong evidence that type Ib/c supernovae are occurring in higher-metallicity host galaxies than type II supernovae. We discuss various implications of our findings for understanding supernova progenitors and their host galaxies, including interesting supernovae found in low-metallicity hosts. ii We present the discovery of the progenitors of SN 2008S and the luminous transient in NGC 300 in archival data obtained with the Spitzer Space Telescope. They are deeply dust-enshrouded massive stars, with extremely red mid-infrared colors compared to other massive stars, and relatively low bolometric luminosities (≈ 5 × 10 L⊙). We discuss the implications of these findings for the evolution and census of "low-mass" massive stars (i.e., ∼8 − 12 M⊙), and we connect it with theoretical discussions of electron-capture supernovae near this mass range, explosive birth of massive white dwarfs, and massive star outbursts. We present a Spitzer low-resolution mid-infrared spectrum of the luminous transient in NGC 300. The spectrum shows that the transient is very luminous in the mid-infrared and most of the pre-existing progenitor dust survived the explosion. Furthermore, the spectrum shows strong, broad emission features that are observed in Galactic carbon-rich proto-planetary nebulae. These observations support our conclusions of an explosive event on a massive carbon-rich AGB or post-AGB star as the origin of the transient in NGC 300 and SN 2008S. We present extensive ugriz Y HJKs photometry and optical spectroscopy of SN 2005gj. These data show that SN 2005gj is the second possible case, after SN 2002ic, of a thermonuclear explosion in a dense circumstellar environment. The interaction of the supernova ejecta with the dense circumstellar medium is stronger than in SN 2002ic.


This paper deals with a two-phase traffic flow LWR model in analyzing the characteristic speeds,strictly hyperbolic property and characteristic decomposition.By designing the high-resolution and higher order accuracy WENO (weighted essentially nonoscillatory) scheme,it achieves satisfactory numerical results that are in accordance with the Riemanns solver as well as the real traffic flow phenomena.It is not difficult for the numerical scheme to be extended to the corresponding multi-phase traffic flow model.


We describe the first prototype version of TransCheck, a system for automatically detecting certain types of translation errors that is based on the notion of bi-text, or aligned corpora of translated texts. We analyse the preliminary results obtained from applying TransCheck to five lengthy samples of published translations, discuss some of the problems that currently lie beyond the system's scope, and conclude by briefly sketching our plans for extending the first TransCheck prototype.


We survey logical formalisms based on inflationary and deflationary fixed points, and compare them to the (more familiar) logics based on least and greatest fixed points.


Abstract Background The current standard technique for diagnosis of bloodstream infection (BSI) is through the detection of micro-organisms using automated blood culture systems and subsequent phenotypic antimicrobial susceptibilty testing (AST) techniques that require 24–48 hours to generate results. The aim of this study was to evaluate the Accelerate Pheno™ system (AXDX), which utilises fluorescent in situ hybridization and morphokinetic cellular analysis to identify bacteria from positive blood cultures and perform AST in less than 7 hours. Methods The Accelerate PhenoTest™ BC kit was used to test 15 gram-negative isolates with a range of AST profiles, from simulated blood cultures. Isolates included 10 target organisms; Escherichia coli (n = 2), Enterobacter sp. (n = 2), Klebsiella sp., Proteus sp., Citrobacter sp., Pseudomonas aeruginosa, Acinetobacter baumannii, Serratia marcescens and 5 non-target organisms. AXDX results were compared with MALDI-ToF MS identification and BD Phoenix™ automated AST results. To evaluate the reproducibility of AXDX analysis, all isolates were tested at two different sites, six in duplicate. Results A total of 37 tests were performed. AXDX correctly identified 90% (9/10) of the target organisms, and correctly identified 100% (5/5) of non-target organisms as such. One isolate of Citrobacter sp. was initially misidentified as Enterobacter sp. but was correctly identified twice on repeat testing. The AST results demonstrated 93% (244/262) essential agreement (MIC within <1 dilution) and 90% (237/262) categorical agreement (same S/I/R interpretation) compared with conventional laboratory methods. For AST results, between-site reproducibility (MIC within <1 dilution) was 97%. Conclusion The Accelerate PhenoTest™ BC kit can provide rapid identification alongside phenotypic AST results direct from positive blood cultures. In this study, the assay demonstrated high reproducibility and good correlation with conventional laboratory methods. By reducing the time to AST results the Accelerate Pheno™ system has the potential to produce actionable results for the management of BSI and enable earlier escalation or de-escalation of antibiotic therapy. This also has the potential to improve patient outcomes by reducing morbidity and mortality. Disclosures K. Roulston, Accelerate Diagnostics: Investigator, Research support; R. Gorton, Accelerate Diagnostics: Investigator, Research support; E. Kazantzaki, Accelerate Diagnostics: Investigator, Research support; M. Rebec, Accelerate Diagnostics: Investigator, Research support; S. Hopkins, Accelerate Diagnostics: Investigator, Research support; G. Satta, Accelerate Diagnostics: Investigator, Research support; D. Mack, Accelerate Diagnostics: Investigator, Research support


If myeloid colony stimulating factors (CSF) were inexpensive, as might be the case if there were real competition amongst products from different companies, clinical decisions about their use to prevent or treat infection would be straightforward. There would be little concern about Medicare impediments to reimbursement for outpatient medications, less financial incentive for growth factor administration in physicians' offices, less angst on the part of patients whomay have to bear some of the costs personally, and a lesser role for the new industry of ''pharmacoeconomists.'' With regard to the latter, because randomized trials do not show a survival benefit from growth factor use, there has been a recent emphasis on issues of cost and improved quality of life. Such ''costeffectiveness'' analyses attempt to determine the fraction of patients who benefit from growth factor treatment and the savings associated with avoidance (or more rapid resolution) of infectious complications and hospitalization. This advantage is then balanced against the costs of growth factor utilization in themajority of patients who do not need or benefit from their modest shortening of the duration of neutropenia. Such calculations often result in the determination of a threshold incidence of neutropenic fever above which the use of growth factors is economically ''cost-effective.'' These computations are often mathematically arcane and replete with assumptions based on imprecise clinical data and estimates of costs/ charges. One suspects, however, that they can (and may) be used by companies to estimate the charges for drugs that the market ''might bear.'' A rational approach to limit use of growth factorswould be to identify individuals at higher risk of either acquiring serious infections or suffering from complications of such infections. A limited number of studies have evaluated starting CSF therapy at the time that neutropenia develops (so called ''afebrile neutropenia''), rather than immediately after chemotherapy is completed, thereby potentially avoiding many days of CSF usage. As summarized in the guidelines from the American Society of Oncology, randomized trials show no benefit from this approach, although not surprisingly, neutrophil counts rise more rapidly in growth factor recipients [1]. The next logical extension would be to start the growth factors when neutropenic fever develops and antibiotic therapy is begun. Rapid initiation of antibiotics dramatically reduces the incidence of bacteremia and death from infection and therefore this approach is unlikely to be associated with increased short-term mortality compared to prophylactic use of growth factors. This was the hypothesis being evaluated by Özkaynak et al. [2] and the Children's Oncology Group in the trial published in this issue of Pediatric Blood and Cancer. Only 67 evaluable patients, most of whom had acute lymphocytic leukemia, were entered on this non-placebo controlled randomized trial because a Data Monitoring Committee felt that there were ''significant differences between regimens in two of the study endpoints'' and recommended that further randomization be stopped. Patient entry onto this study was relatively sluggish as 67 patients were accrued over a 3.5 years period of time. Indeed, there was a substantial reduction in the time to resolution of febrile neutropenia. This was largely a consequence of more rapid recovery to>500 neutrophils/ ml, since the time to resolution of fever was identical in the two groups.However, therewas no effect on the number of days of antibiotic use, the need for antifungal therapy, and overall outcome. One wonders whether the duration of febrile neutropenia was the most clinically relevant primary endpoint and whether the DSMB might have pulled out the rug a bit prematurely. Arguably, a more critical clinical endpoint, which reflects the comfort of the clinician that the patient has recovered, is the duration of hospitalization. Although the 1-day difference in hospitalization was ''statistically significant,'' it is certainly a modest benefit and in fact, the longest duration of hospitalization was only 12 days, suggesting that there were few patients with serious infections entered on the trial. This was consistent with the eligibility criteria, which excluded patients with clinical features associated with higher risk. A number of studies [3] have identified certain chemotherapeutic regimens, the expected duration of severe neutropenia, the presence of medical comorbidities and older age as factors predicting poorer tolerance of infections and more details might have been helpful in placing the results of this trial in context.


The Republic of Ireland (ROI) is a low incidence TB country. The last reform of TB services in the ROI in 2003 recommended that most TB management should be delivered on an outpatient basis with 3 hospitals being designated as TB centres. Our aim was to describe the utilization of hospital inpatient care by patients with TB in the Republic of Ireland.

 Hospital coding data were searched to identify TB hospital discharges between 01/01/2015-31/12/18. The projected cost of TB episodes of care was calculated using payment rules for public hospitals in Ireland.

 1185 admissions with TB as the principal diagnosis were identified. 801/1185 (68%) episodes of care were emergencies and 384/1185 (32%) were elective We estimate that 65.1% (818/1257) patients with TB notified in the Republic of Ireland from 2015-2018 had an episode of care in a public hospital and (50.8%) 639/818 had an emergency episode of care. We estimate that mean annual cost of TB inpatient care per year in the ROI from 2015-2018 was €2,638,828 - 2,955,047, with emergency episodes of care costing an average of €2,250,926 - 2,557,397 per year.

 The burden of TB on hospital inpatient care in the Republic of Ireland is significant.
 The national TB policy should change in recognition of this.

 All Authors: No reported disclosures


In this paper I engage with how we attend to sound in terms of musical performance, but also more generally. Whilst recent work in geography has begun to approach the significance of practices of listening, particularly in terms of its performance, its interpretative role, and its cultural politics, I want to approach the act of listening itself and sound itself. In doing this I take inspiration from the recent work of Nancy and particularly his rethinking of ontology as being-with. More specifically, I will focus on three themes central to his general philosophical project, namely sense, the subject, the body, and, further, his conceptions of sonorous presence, resonance, rhythm, and timbre which relate more specifically to his work on listening. The discussion decentres the role of interpretation, or as Nancy suggests 'hearing', in academic and geographic accounts of listening and calls for a greater understanding of the resonance produced when sound impacts upon the body when we 'listen'. In turn, this contributes to the development of a postphenomenology through its critique of the intentional subject in understanding the subject as resonant, always still to come, folding and unfolded, echoing in its being-with sound. This also develops understandings of the nonrepresentational in its affirmation of a finite thinking of the singular-plural. I take as a lens into this discussion a recent experiment undertaken by the Washington Post where the world-renowned, virtuoso violinist Joshua Bell busked at a Washington Underground station, and, apparently, fell on a thousand pairs of 'deaf ears'.


In the present paper, the results of the research on light characteristics of gallium arsenic two-barrier n-pm-structure analogue of bipolar phototransistor are presented. Experimentally, it is shown that photoelectric characteristics vary depending on switching on conditions of nGaAs-pGaAs-Ag structure. The researched structures differ with functionability in photodiode and phototransistor modes as microduty devices.


Production of animal biomass and the number of trophic levels supported by an ecosystem depend in part on rates of primary production, disturbance, predator–prey interactions, and the efficiency of energy flow through food webs. Of these factors, food web efficiency has been among the most difficult to quantify empirically. Thus, both the drivers and consequences of variation in food web efficiency remain largely unstudied in field settings. We estimated food web efficiency in nine desert streams spanning gradients of flash flood recurrence, resource availability, and trophic structure. Food web efficiency was estimated as fish community production relative to gross primary production at an annual timescale, based on quarterly observations of fish biomass and stream metabolism. Gross primary production was greatest in streams characterized by flashier flow regimes and greater relative light, temperature, and nitrogen availability. Fish production ranged from 0.02 to 0.50 g C m−2 yr−1, food web efficiency ranged from 9.5 × 10−5 to 1.8 × 10−2, and both properties decreased with flashier flow regime, light, temperature, and nitrogen availability, but were not associated with food chain length. These results, combined with opposite effects of environmental variation on primary vs. fish production, indicated that the effects of disturbance regime (i.e., scouring floods), light, and temperature on fish production were not strongly mediated by bottom‐up controls. Estimates of food web efficiency under ambient disturbance and resource regimes suggest that a decoupling of energy flow from primary producers to upper trophic levels may prevail in hydrologically dynamic desert stream ecosystems.


Classes of oceanographic missions addressing relevant distinct scientific and applied objectives in the Portuguese coastal waters are examined in the context of an R&D project aiming at providing a methodological framework adapted to the specific requirements of AUV-based systems design. Preliminary results consisting on the mapping of requirements onto a modular system are presented.


State of the art acoustic scene classification techniques often employ features of large dimensionality, which are then used to train and perform inferences with kernel machines such as Support Vector Machines. However, the complexity of computing the non-linear kernel matrix for these methods increases with the dimensionality of the features and the size of the dataset. In this work, we introduce a new scheme that hashes features, which combined with a linear function approximates a non-linear Laplacian kernel. Each hash typically has lower dimensionality than the input features and each component is represented by one bit instead of floating values. Hence, allowing efficient computation of the kernel matrix using XOR operations rather than dot-products. Our scheme is demonstrated mathematically and tested in the 2017 DCASE: Acoustic Scene Classification. The hashes reduce up to six powers of two the feature representation with minimal loss of accuracy.


INTRODUCTIONThe amount of air that will flow through the Strain Isolation Pad (SIP) for agiven pressure differential is a critical parameter in the Shuttle Orbiter Thermal. Protection System (TPS) design. On ascent, the flow characteristics of the SIPdetermines the venting rate of the SIP which, in turn, partially determines theforces on the tile. This problem is of particular interest during the transonicportion of the ascent when the normal shock can rapidly pass over a tile, thusexposing it to the pressure drop across the shock and imposing maximumdependenceon the venting capabilities of the TPS. If the SIP could not vent quickly enough,there would be sufficient pressure difference to tear the tile from the SIP.During the descent, some areas of the Orbiter will experience local pressuregradients over the TPS, due either to surface contour or a local excresence, thatare constant for significant periods of time. The flow characteristics of the SIPis one of the factors that determine the amount of hot air that will circulateunder the TPS due to a pressure gradient. Filler bar charring has occurred oneach of the first five Shuttle flights and is believed to be directly related tothis circulation. References I and 2 present this problem in detail.In order to study the damagepotential of situations as described inreferences i and 2 , it is necessary to perform engineering calculations of theTPS flow. The parameter of interest is the resistance of the particular medium tothe flow. Review of the literature reveals engineering practice and data largelybased on packed beds of sand and similar geometries, references. 3, 4, and 5. The


Allow natural death (AND) seems hopelessly vague and negative.1 Since 2006 at this hospital we have replaced the do not resuscitate (DNR) process with treatment escalation plans. …


SUMMARY
The development of chromophores in the glucose-glycine and sucrose-glycine systems was examined. During the reaction a number of conjugated unsaturated carbonyl compounds develop, the quality present at any one time being greater as the reaction proceeds, until browning is well advanced. During this period, which follows the period of rapid pH fall and α-amino N utilization, the fluorescence of the system increases, and the quantity of water-soluble, non-volatile compounds extraetable into various organic solvents increases. The pattern of extraction indicates the gradual formation of intermediates of greater dehydration and greater light-absorbing properties from smaller molecules. The presence of sulfites slowed the rate of development of conjugated unsaturated carbonylic and fluorescent compounds, and of subsequent early browning, whereas in the presence of sodium pyrophosphate, their rates of production are increased. Chromophores appear to develop at a faster rate in the presence of iron than in its absence, but apparently by a mechanism different from that occurring with phosphates.

It is suggested that the production of larger carbonylic N-containing polymers from smaller carbonyl compounds, occurs in the sugar-amino compound systems.


tions, the woman citizen, civic influence of religion, and civic attitudes. Mr. Gaus is less matter of fact, less exhaustive, less systematic than Mr. Harper—and within his rights. In contrast with the latter's steel engraving, here is an impressionist picture of British society worthy of being hung in any good gallery of modern art. As such, it is appropriate to the subject, and entertaining besides. For example, instead of giving us an analysis of the various education acts, for instance, 23 Victoria, c. 12, or whatever it maybe, Mr. Gaus includes such "gems of thought" as this extract from a speech by a member of a British patriotic society respecting the civic upbringing of the proletariat: "In Pentonville we have the children in on Friday evening, with their dirt and everything. We are going to teach them to love Old England, the King, and the Empire, and to feel jolly well proud of themselves." Much more illuminating this than "Be it enacted, etc." True-born Britishers, no doubt, will contend that Mr. Gaus has not penetrated to "the soul of Britain," for they do not admit that even Henry James could make the grade. But it will do them no harm to look at themselves in Mr. Gaus's mirror. John may be fatter than Sam, but the resemblance is unmistakable. Mr. Merriam is to be congratulated on his program and the parts thus far realized. CHARLES A. BEABD. New Milford, Connecticut.


The story of tuberculosis has been narrated several times with great grief and sorrow depicting the sufferings of humanity over a substantial period of history. Thomas M. Daniel's book, Captain of Death: The Story of Tuberculosis, tells the tragic history of this disease, which at one point of history was known as the 'white plague.' Many sufferings attached with the disease later become part of romantic literature as leading tales. Stories of Novalis, Keats, Chopin, and the Bronte sisters dominated as 'paradigms of romantic tubercular sufferings.' Daniel's book gives a full account of measures taken to control the menace of tuberculosis, which ultimately was effectively controlled. Daniel also mentions the desperate situation in Haiti where controlling tuberculosis is still a dream, and asserts that a lot more needs to be done to share the remedies of this disease.The story of tuberculosis does not end there. It is indeed the start of another story. For advanced and developed countries, the prevalence of tuberculosis in its traditional form is a matter of history. For the developing world, this past is present. In India, tuberculosis is one of the leading causes of mortality, responsible for the death of two persons every three minutes, nearly 1,000 every day. According to the World Health Organization, India accounts for one-fifth of the global tuberculosis cases. Acute poverty and malnutrition have further aggravated the situation for India's 'Slumdog Millions'.


A Master of Science thesis in Mathematics by Khitam Zuhair Aqel entitled, "Some applications of the Hyperbolic Metric," submitted in June 2015. Thesis advisor is Dr. Yusuf Abumuhanna. Soft and hard copy available.


Compression failure of sandwich specimens with glass/vinylester face sheets over PVC foams has been experimentally examined using an end loading test fixture based on the ASTM C 364 standard. The main objective of the research was to examine the roles of the faces and core in the mechanism of failure and ultimate load carrying ability of the structure. A range of PVC foam densities, core thicknesses, and specimen lengths were examined. Failure modes were identified, and compression strengths were compared to analytical predictions. Short specimens failed by compression failure of the face sheets up to a gage length that increased with increased foam density, and decreasing core thickness. At intermediate gage lengths it was found that specimens with a thick low density core failed in an anti-symmetric face wrinkling mode, while long specimens failed by global buckling in the fundamental buckling mode. Predictions of the failure loads were found to be in reasonable agreement with experimental results.


Background Since activation of the PI3K/(protein kinase B; PKB/akt) pathway has been shown to alter muscle mass and growth, the aim of this study was to determine whether resistance exercise increased insulin like growth factor (IGF) I/phosphoinositide 3-kinase (PI3K) signalling and whether altering PI(3,4,5)P3 metabolism genetically would increase load induced muscle growth. Methodology/Principal Findings Acute and chronic resistance exercise in wild type and muscle specific PTEN knockout mice were used to address the role of PI(3,4,5)P3 regulation in the development of skeletal muscle hypertrophy. Acute resistance exercise did not increase either IGF-1 receptor phosphorylation or IRS1/2 associated p85. Since insulin/IGF signalling to PI3K was unchanged, we next sought to determine whether inactivation of PTEN played a role in load-induced muscle growth. Muscle specific knockout of PTEN resulted in small but significant increases in heart (PTEN+/+  = 5.00±0.02 mg/g, PTEN−/−  = 5.50±0.09 mg/g), and TA (PTEN+/+  = 1.74±0.04 mg/g, PTEN−/−  = 1.89 ±0.03) muscle mass, while the GTN, SOL, EDL and PLN remain unchanged. Following ablation, hypertrophy of the PLN, SOL or EDL muscles was similar between PTEN−/− and PTEN+/+ animals. Even though there were some changes in overload-induced PKB and S6K1 phosphorylation, 1 hr following acute resistance exercise there was no difference in the phosphorylation state of S6K1 Thr389 between genotypes. Conclusions/Significance These data suggest that physiological loading does not lead to the enhanced activation of the PI3K/PKB/mTORC1 axis and that neither PI3K activation nor PTEN, and by extension PI(3,4,5)P3 levels, play a significant role in adult skeletal muscle growth.


A field experiment was carried out at Chirrori farm of Sardar Vallabhbhai Patel University of Agriculture and Technology, Meerut (U.P.) in spilt plot design. The main plots in the study included four irrigation scheduling namely, continuous shallow flooding irrigation at 10 kPa (I1), alternate wetting drying irrigation at 20 kPa (I2), alternate wetting drying irrigation at 20 kPa with irrigation after herbicide application (I3) and alternate wetting drying irrigation at 20 kPa with mid-season drying (45 to 80 DAS irrigation at 40 kPa) (I4) and sub-plot with weed management treatments i.e. weedy treatment (W1), weed free (W2), pre-emergence Pendimethalin @ 1 kg a.i. ha fb post-emergence Bispyribac-Na @ 25 g a.i. ha (W3) and Propanil @ 4 kg a.i. ha + Pendimethalin 1 kg a.i. ha (W4). Continuous shallow flooding irrigation at 10 kPa (I1) reduces the weed density significantly. The applications of Pendimethalin 1 kg a.i. ha at 3 DAS followed by Bispyribac 25 g a.i. ha at 25 DAS (W3) controlled weed very effectively and produce similar yield (6.32 t ha) as weed free (W2) (6.67 t ha). However, the study also suggested that detail study should be carried out to understand interaction of irrigation scheduling and weed management practices.


Fixed assets are one of the assets that a company uses to carry out operational
activities. Fixed assets have a useful life of more than 1 year and have a
measurable and meaningful value for the company that affects the amount of
wealth in the financial statements. The accounting treatment for property, plant
and equipment is also based on PSAK 16 and also based on UU PPh no. 36 of
2008, the accounting treatment `of such fixed assets has several fundamental
differences, resulting in a difference in the amount of fixed assets. Which are
presented in commercial and fiscal reports. Therefore, the authors are interested
to know the difference in accounting treatment based on PSAK 16 and UU PPh
no. 36 of 2008. The research method used is descriptive quantitative method.
Based on the research shows that a significant comparison is seen in the cost of
assets, the determination of useful life, at the beginning of the depreciation, the
value of residual fixed assets and fixed asset depreciation method. Good fixed
asset treatment must comply with the provisions of PSAK 16 and UU PPh no. 36
of 2008 so that the fixed assets present in the financial statements can be
presented reliably and clearly.
Keywords: Fixed Assets, PSAK 16, Tax Law Number 36 Year 2008


The invention discloses a remote temperature and humidity monitoring system based on cloud storage. The remote temperature and humidity monitoring system comprises temperature and humidity data collection and transmission modules, a remote terminal, a monitoring computer and a temperature and humidity adjusting device. A plurality of temperature and humidity data collection and transmission modules are sequentially connected and then are communicated with the monitoring computer through a repeater. The monitoring computer is communicated, through the internet, with the remote terminal provided with client-side software. The monitoring computer is connected with the temperature and humidity adjusting device. A plurality of paths of monitoring data are transmitted into the monitoring computer through a control PCI board card. The temperature and humidity data collection and transmission modules are further communicated with a cloud server. Data monitoring of an intelligent cell phone is realized through the internet on the basis of the temperature and humidity monitoring system. According to the remote temperature and humidity monitoring system, the remote terminal is further arranged on a wireless temperature and humidity monitoring system based on the cloud storage so as to obtain monitoring data, and a data monitoring person is not limited by areas and can realize inquiry of the monitoring data.


FIELD: machine building. SUBSTANCE: field maintenance device (280) includes a processor (282) of the field maintenance device and storage system (285), at that processor (282) of the field maintenance device is configured such that to receive values (252a) extracted during operation prior to replacement, to receive values (252b) extracted during operation after replacement, when the old processing system was replaced by replacing processing system, to form one or more scale coefficients (266) as ratio of one or more values (252a) extracted during operation prior to replacement to one or more values (252b) extracted during operation after replacement, and to load one or more scale coefficients (266). EFFECT: increased reliability of operation of the field maintenance device of the vibration flowmeter. 18 cl, 4 dwg


【Objective】 To establish rhabdomyosarcoma model for researching the mechanism of lymphatic and hematogenous metastasis in order to provide theoretical basis for clinical myosarcoma treatment.【Method】 30 mice were inoculated with malignant ascites of S180 mice in muscular layer of gluteal region to establish myofibrosarcoma orthotopic tumor model.The mice were sacrificed in the different time after 1 week and the volume and weight of tumors were detected.The condition of neoplasm metastasis and the relation of tumor vessel and the growth of lymphatic and tumor metastatic were observed after opening the chest and abdomen.the tissue of tumor was used for embedding and slicing.Immunohistochemisty and western blot were used to detect the expression of VEGF-C.LMVD in myosarcoma was calculated by using LYVE-1 as the specific marker of lymphatic endothelium.【Results】 There were many lymphatic vessels in centre and marginal zone of rhabdomyosarcoma tissue.It showed that rhabdomyosarcoma tissue had lymphatic hyperplasia and neogenesis.【Conclusion】 The positive expression of VEGF-C in rhabdomyosarcoma is related with lymphatic neogenesis.VEGF-C might play an important role in lymphatic metastasis of rhabdomyosarcoma.


In cases of systematic lupus erythematosus (SLE) that lead to surgery due to the development of heart diseases such as valvular disease, ischemic heart disease and aortic aneurysm, early detection and careful monitoring are important. An absence of background diseases or immunopathological examination of the myocardial tissue in SLE cases with cardiovascular lesions demonstrates the lack of knowledge in this area. In recent years, however, there have been reports of neutrophil extracellular traps being involved in the fulminant onset of SLE.This study aimed to analyze clinically and immunohistopathologically the pathophysiology of heart diseases associated with SLE.We performed left atrial appendage resection in 34 patients, including patients with cardiovascular lesions, who underwent heart surgery for SLE complications from 2012 to 2021. Tissue analysis was conducted in 9 cases. The left atrial appendage, in cases of non-collagen valvular disease, was used as the control. Tissue staining of cardiomyocytes was carried out by adding anti-neutrophil extracellular(NE) antibodies(Abs) to anti-human IgG antibody (Ab), anti-IgM Ab and anti-C3 Ab.Of the 34 SLE patients 14 had valvular disease, 8 had ischemic heart disease and 12 had aneurysms. Preoperative SLE activity was relatively stable with only 1 patient below the CH50 standard and 6 patients above the anti-DNA Ab standard. The Ab positivity rate for the patients in this study was higher than that of the 687 SLE patients who were previously tested in 2019. The presence of anti-CL Abs was 55.6%, which was higher than the 25.5% observed in previous SLE patients. In this study, anti-SS-A and anti-RNP Abs tended to be relatively numerous. An example of immunohistochemical staining of IgG in the left atrial appendage is presented (Figure 1a). IgG deposits were not observed on the left side of the myocardial fibers in the control group, whereas IgG deposits were observed on the right side in the SLE group. Deposits were also observed in tissues that were not located in the affected areas. The presence or absence of tissue deposition in the myocardial fibers and clinical findings in 2 cases of the control group and 9 cases of the SLE complication group are reported in Table 1. IgG deposits were found in the myocardial fibers of 6 of the 9 patients in the SLE complication group, and deposits were found in the left atrial appendage tissue regardless of the type of heart disease, suggesting a potential change in the heart tissue. In the SLE group, 5 cases were positive for antiphospholipid (APS) Abs, while 7 cases were positive for either anti-SS-A or anti-RNP Abs. Only 2 cases had elevated preoperative anti-DNA Ab and complement reduction. Of the SLE complication group, 2 of the 9 cases were negative for all Abs but IgG deposits were observed in a case. Of these 4 cases were selected and stained with anti-IgM, anti-C3 and anti-NE Abs. However IgM and C3 deposits were only observed in one patient who developed myocardial infarction at the age of 39 and was triple positive for APS, anti-SS-A and anti-RNP Abs (Figure 1b). There were also no NE deposits in any of the cases. Even if complement and anti-DNA Ab levels in the serum are normal, attention should be paid to heart disease complications during the long-term observation of SLE patients. In particular, attention should be paid to various autoantibody-positive cases such as APS, anti-SS-A Ab and anti-RNP Ab. The anti-NE Ab was not stained in this study because the tissue was different from the lesion site and because it occurred during the chronic course.In SLE patients who developed cardiovascular lesions and required surgery, immunological abnormalities may occur in the myocardial tissue even if serum complement and anti-DNA Ab levels are stable.[1]Stephane Zuily et al. Valvular Curr Rheumatol Rep (2013) 15:320.[2]Zawadowski GM et al. Lupus. 2012;21(13):1378-84.[3]Daniel Appelgren et al. Autoimmunity 2018,vol51,No.6,310-318.None declared


The use of modified tibial plateau leveling osteotomy adapted for correction of the lateral patellar dislocation was effective, allowing simultaneous treatment of lateral patellar luxation and cranial cruciate ligament deficiency.


The Journal continues to make progress toward its goal of serving as facilitator and guide to the profession. After 1 1/2 years, JOSPT now has more than 10 000 subscribers, more than 700 of which a...


Inquiry into Occurrence of Byssinosis in Jute Mill Workers: B.P. Chattopadhyay, et al. Regional Occupational Health Center E—An epidemiological study was carried out on 196 jute mill workers to inquire into the occurrence of byssinosis and to study the pattern of pre‐shift and post‐shift changes in ventilatory functions during the working week. The respiratory symptoms were recorded in a questionnaire based on the definition of byssinosis. The pulmonary function tests (PFT) were done by means of a dry wedge bellows spirometer, Vitalograph. On each day, the PFT of the workers were done twice, i.e., half an hour before the beginning of work (pre‐shift record), and after five hours of work (post‐shift record) on six consecutive working days. In the present communication mainly the PFT results for the first working day are reported. The acute and chronic changes in ventilatory function were defined as recommended by the World Health Organization. Typical symptoms of byssinosis such as chest tightness and difficulty in breathing on the first day of the week (Monday) after a weekend rest were found in 18 (9.18%) workers. Another group of 28 (14.28%) workers complained of chest tightness and breathlessness after work on days other than Monday. This group of workers was referred to as having "atypical byssinosis". A significant fall (post shift fall in FEV1 5% and more than the pre shift FEV1.0 value) was observed in 70 (35.71%) workers and chronic changes in FEV1.0 in 62 (31.63%) workers, respectively. It is concluded that the jute mill workers suffer from a specific respiratory morbidity which resemble the byssinosis observed in cotton, flax and hemp workers.


Context: Occipital neuralgia is characterized as uni or bilateral pain in the topography of the occipital nerve. The condition may be harrowing or acute and worsens with digital pressure on the back of the neck. The pain appears in the distribution of the greater (GON), minor (LON), and third (TON) occipital nerves. Besides that, it may radiate to the retro-orbital region and angle of the mandible, and it can be associated with paresthesias. A less common cause is direct head trauma, and it is believed that the mechanism for its development is the injury or entrapment of the nerve fibers due to post-traumatic fibrosis. The conservative treatment consists of antiepileptics, tricyclic antidepressants, or antipsychotics. In addition, it includes anesthetic blockade of the GON, LON, and TON guided by ultrasonography of the skull, which is an essential option for treatment and identifies the presence of entrapment of the quoted structures. We present the case of a 37-year-old man, a victim of physical aggression with traumatic brain injury, without previous comorbidities or use of daily medications, who developed occipital neuralgia after the event. Cranial computed tomography showed occipital depression in the topography of the GON. Due to the absence of neurological alterations, the medical team chose conservative treatment with phenytoin. As the pain persisted, the professionals performed a hydro section and suboccipital block with anesthesia, resulting in improvements.


Professor Hoeflich explores the notion of serendipity and its components as they relate to historians, particularly legal historians, and to those institutions - libraries and archives - that present the opportunities for serendipity to work its magic. He also discusses the ways in which libraries and archives can help to encourage serendipitous discoveries, and the dangers he sees in over-efficient and economically rational disposal policies, including reproduction instead of preservation of originals.


BACKGROUND
A combination of antibiotics, including metronidazole (MET), ciprofloxacin (CIP), and minocycline (MINO), has been demonstrated to disinfect bacteria in necrotic teeth before regenerative processes. It has been presented clinically that antibiotic pastes may drive to possible stem cell death, difficulties in removing from the canal system, which can limit the regenerative procedure. This study was designed to (1) synthesize nanofibrous webs containing various concentrations of different medicaments (triple, double, and calcium hydroxide, Ca(OH)2), (2) coat this electrospun fibrous gutta-percha (GP) cones.

METHODS
Poly(vinylpyrrolidone) (PVP)-based electrospun fibrous webs were processed with low medicaments' concentrations. Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDX), and X-Ray Photoelectron Spectroscopy (XPS) were carried out to investigate fiber morphology, antibiotic incorporation, and characterized GP-coated fibrous webs, respectively. The chemical and physical properties of dentine were carried out via Fourier Transform Infrared Spectroscopy (FTIR) and Nano-SEM, respectively. The antimicrobial properties of the different fibrous webs were assessed against various bacteria by direct nanofiber/bacteria contact. Cytocompatibility was measured by applying the MTT method.

RESULTS
The mean fiber diameter of the experiment groups of medicament-containing fibers ranged in the nm scale and was significantly smaller than PVP fibers. EDX analysis confirmed the presence of medicaments in the nanofibers. XPS analysis presented a complete coating of the fibers with GPs; FTIR and Nano-SEM showed no chemical and physical configuration of intracanal medicaments on the dentine surface. Meanwhile, nanofibrous webs led to a significant reduction in the percentage of viable bacteria compared with the negative control and PVP.

CONCLUSION
Our findings suggest that TA-NFs, DA-NFs, and Ca(OH)2)-NFs coated GP cones have significant potential in eliminating intracanal bacteria, cell-friendly behavior, and clinical usage features.


The cultural difference has been the important factor of influencing the marketing behaviors all the time.It has been the focal point how to describe accurately the difference between culture through unifying the mode in the theory circle of the marketing.Hofstede made laying a foundation contribution;Schwartz model is regarded as the research that has vitality most;the comprehensive cultural difference model of Terry Clark integrated the double influences between consumers and sales men.


Since the emergence of the first web development frameworks at the turn of the 21st century, many of them have made a name for themselves and rose to wide popularity only to be later ousted by newer frameworks and sometimes even fall to obscurity. In our paper, we would like to depict the last fifteen years of the changing popularity of web development frameworks by observing the number of newly created repositories in open-source projects hosted at GitHub that were based on them as well as the number of questions posted on Stack Overflow regarding the respective frameworks. We analyze the correspondence between these two indicators and put them in the context of the popularity of the programming languages that the respective frameworks are based on, as measured by the TIOBE Programming Community index, in an effort to check whether one source could be used to forecast another.


HARTZ, JASON M., Ph.D., November 2010, Interdisciplinary Arts The Plow That Broke the Plains: An Application of Functional Americanism in Music Director of Dissertation: Dora J. Wilson This dissertation explores the nature of American musical identity in the score from the 1936 documentary film The Plow That Broke the Plains, directed by Pare Lorentz, scored by Virgil Thomson, and created under the auspices of the New Deal's Resettlement Administration. While the score offers a study in modernist music and compositional musical Americanism, other approaches may be more suited to positioning this New Deal cultural artifact within its historical context, thus revealing its cultural sources and social intentions. In the spirit of contemporary musicology, this project proposes a new category through which to undertake such studies: functional Americanism. Functional Americanism evaluates American identity in music through the function or utility of music operating in an American setting or for an American purpose. Using this approach to engage with The Plow, this study draws from social history, cultural studies, and musicology in order to understand The Plow within its historical moment as an articulator of American identity. Approved: ____________________________________________________________ Dora J. Wilson Professor of Interdisciplinary Arts


Sir, X-linked ichthyosis (XLI) appears in the immediate neonatal period as a generalized large, slightly adherent, lightly coloured desquamation commonly affecting the scalp, preauricular area and posterior neck (1). In time, large, often dark scales, preferentially located on the trunk and extensor aspect of the extremities, become prominent. The palms, soles and face are generally spared (1). Cutaneous histopathological findings of XLI are not diagnostic, being characterized by orthokeratotic hyperkeratosis and a normal or slightly thickened granular layer. In the dermis, oedema and a slight perivascular inflammatory infiltrate can be observed (1). The most common associated extracutaneous findings include corneal opacities, cryptorchidism, epilepsy and electro-encephalographic changes (1). XLI is caused by deficient activity of the steroid sulphatase (STS) enzyme due, in most patients, to complete or partial deletions of the STS gene mapped on Xp22.3 (2–5). Therapeutic approaches for the treatment of mild to moderate cutaneous manifestations of XLI include keratolytic agents, moisturizers and topical retinoids, while systemic retinoids have been successfully employed in severe forms (6, 7). We describe a 22-year-old man with XLI associated with epilepsy. A within-patient study comparing topical tazarotene 0.05% and glycolic acid 70% resulted in almost complete remission of cutaneous lesions, although a longer response durability was achieved with tazarotene.


The conditions for induction of biosynthesis of specific neuraminidase (N-acyl-neuraminyl hydrolase, EC 220.127.116.11) by Klebsiella aerogenes NCIB 9479 are described. A range of neuraminyl-containing compounds derived from varied biological sources can induce enzyme biosynthesis; others are ineffective; comparisons are drawn between inducer potential and other biological activities of the compounds and the significance of steric conformation is emphasised. The location of the enzyme in the bacterial cell was investigated and the partially purified enzyme had a pH optimum of 5.6.


foreign language programs—for example, Long's and Larsen-Freeman's overviews of the theoretical issues involved in evaluation and selection of teaching methodologies, W. E. Lambert on quantitative analysis in language learning studies, Klein-Braley's and Oscarson's papers on language testing, and Mitchell's evaluation of foreign language teaching projects and programs. Also interesting are the interdisciplinary papers relating language teaching research to linguistic theory (Flynn), to cultural/anthropological issues (Kramsch), and to recent developments in artificial intelligence (Ginsberg). The volume also offers two, necessarily selective overviews of language learning research traditions in the United States (Ferguson & Huebner) and Europe (van Els, de Bot, & Weltens). theories outside of of specialization. Functional Grammar is a very useful contribu-tion toward this Siewierska, an outsider in close contact with the major practitioners of the theory, gives it a sympathetic overview, together with discussion of its certain problems. There are frequent comparisons to other theories, including government-binding theory, lexi-cal-functional grammar, relational grammar, role and reference grammar, head-driven phrase structure grammar, lexicase, dependency grammar, and systemic grammar. Data from a wide variety of languages are discussed, including some well-known syntactic controversies, such as the argument structure of Philippinian languages. The text presupposes some familiarity with the issues discussed and is not for beginning students. Not unreasonably, considering its intent, it makes no mention of second language acquisition. Functional grammar is a syntactic theory that, like other functionalist theories, gives priority to the communicative and social aspects of language as the basis of linguistic explanation. As currently formulated, it is a sentence grammar intended as a component of a wider theory of discourse. Its basic theoretical elements are not structural and configurational categories such as noun phrase and verb phrase, as in Chomskyan government-binding theory, but functional categories such as agent, subject, and topic. For Siewierska, its chief interest lies in its high degree of explicitness and consistency, in contrast to other functionalist theories.


In January 2021, a new Editorial Team officially began its term at Group & Organization Management (GOM). My experience with GOM began in 2005 as a doc student, when my colleagues and I submitted a paper on social networks and citizenship behavior (Zagenczyk, Gibney, Murrell, & Boss, 2008), followed by a paper introducing the perceived organizational obstruction construct (Gibney, Zagenczyk, & Masters, 2009) which won the "best quantitative paper" award. Through my research and service to the journal—reviewing (2010), editorial board (2013), Associate Editor on Bill Gardner's team (2017)—I came to identify quite strongly with GOM and noticed (at editorial board meetings primarily and through other interactions) that many others did as well. My own—and others'—identification made the decision to take on the role of Editor-in-Chief when it was offered in 2019 a relatively easy one, as did knowing that Bill and his team would be transferring to my team a journal that was in excellent health (Gardner, 2020). We will continue the service-oriented culture that Bill and his team fostered over the last 6 years by treating all stakeholders with fairness and respect. We continue to welcome empirical and conceptual papers that extend management/organization science with a focus on individual behavior, teams and groups, and strategy/organizational theory. We aim to provide constructive and actionable feedback on all manuscripts in a timely fashion. In the following sections, I describe some of our new initiatives, as well as some changes to the structure and operation of GOM resulting from its demonstrated growth and forecasted trajectory. We are looking for papers that make (1) a strong theoretical contribution (for example, see Shoss, Horan, DiStaso, LeNoble, & Naranjo (2021)); (2) a strong empirical contribution (for example, see Bernerth & Walker (2020)); or (3) some balance of both (for example, see Loignon, Woehr, Loughry, & Ohland (2019)). We are particularly excited to publish papers that draw on social network methodologies, make methodological contributions, explore


Executable is downloaded to the audio output device through a communications link. Executable may constitute an audio output device to decode the audio encoded in a specific format. Executable, Additionally or alternatively, the may comprise a different audio processing software. Audio may include voice and / or audio playback (for example, music playback). The ability to download audio executable, makes it possible to dynamically provide various decode and / or audio processing capabilities to the audio output device. This eliminates the need to transcode digitized audio for playback on an audio output device, audio output device, without the need to have a plurality of audio decoders permanently audio output in the device, a plurality of audio formats It makes it possible to decode. .FIELD 1


Red Angus specific genomic predictors were evaluated using EPD, Beef Improvement Federation accuracies, and MBV provided by the Red Angus Association of America for genotyped animals (n = 233) not used in training of the MBV. For each trait, there were two different prediction equations used to derive the MBV: one from Iowa State University and the National Beef Cattle Evaluation Consortium (NBCEC), and the other from Zoetis. The two training populations differed in the specific animals used, in the number of animals used, and the statistical model used. However, there was likely a considerable degree of overlap between the two training populations. Both MBV were evaluated if a MBV and corresponding EPD existed. The EPD were transformed by deregressing them and weighting them following the methods of Garrick and others (Genetics Selection Evolution, 2009). Beef Improvement Federation accuracies were transformed into the reliabilities used in the weighting of the deregressed EPD. The unweighted heritability of the deregressed EPD was set to an arbitrary value (0.4). To check that the final results were not sensitive to the choice of heritability, the analysis was rerun at different values of heritability and, as expected, the same results were obtained each time. A fourgeneration pedigree was constructed for the genotyped animals used in the evaluation. A two-trait linear mixed model was fitted using ASReml. The dependent variables were the MBV and weighted deregressed EPD. The model for the MBV included a fixed effect for the intercept, a random additive genetic effect, and a residual with variance fixed at 0.0001% of the unweighted phenotypic variance of the deregressed EPD. The model for the deregressed EPD included a fixed effect for the intercept, a random additive genetic effect, and a weighted random residual. The additive genetic and unweighted residual variances for the deregressed EPD were fixed at 0.4 and 0.6 of the deregressed unweighted phenotypic variance of the EPD, respectively . Any deregressed EPD with a reliability less than 0.1 was removed prior to analysis. The analysis was rerun without this edit and the results were very similar.


We examine the relationship between geographic distance and corporate tax avoidance in China and find that the closer a firm is to the tax bureau, the less it is likely to avoid tax. This is in sharp contrast to the findings documented by Kubick et al. for U.S. public firms. We argue that this is the result of the local tax bureau collecting more information about the firm instead of the firm collecting more information about tax audits as suggested by Kubick et al. We attribute the different results to the tax system difference between China and the United States, as it is easier for the tax officials in China to collect information about the tax-paying firms. Cross-sectional analyses considering firm age or functional proximity provide further corroborating evidence.


Various applications, such as electronic business, satellite remote sensing, intrusion discovery, and network traffic monitoring, generate large unbounded data stream sequences at a rapid pace. The clustering of data streams has attracted considerable interest due to the increasing usage of evolving data streams. In particular, evolving data streams affect clustering because they introduce numerous challenges, such as time and memory limits and one-pass clustering. Furthermore, researchers need to be able to determine arbitrarily shaped clusters present in evolving data streams from applications. Due to these characteristics, conventional density grid-based clustering techniques cannot be used. Moreover, the existing density grid-based clustering algorithms have low cluster quality for clustering evolving data streams. This study conducted a systematic literature review (SLR) and noted numerous research-related issues encountered in solving the aforementioned problems. We summarized numerous grid-based clustering algorithms that have been used and determined their distinctive and limited features. We also observed how these algorithms address the challenges affecting the clustering of evolving data streams and studied their advantages and disadvantages. SLR was based on 104 articles published between 2010 and 2021. Numerous challenges remain for grid-based clustering algorithms, particularly in terms of time-limited and high-dimensional data handling. Last, our findings indicated a variety of active studies on density grid-based clustering.


The lifetime of the AΣu+2 state of N3 has been determined from line broadening in the rotationally resolved laser-induced fluorescence (LIF) spectrum of the AΣu+2–XΠg2 transition. N3 radicals, produced by fluorine atom abstraction from HN3, were probed with an intracavity doubled ring laser operating near 272nm. Careful examination of the LIF spectrum indicates a significant Lorentzian component to the line shape due to a rapid predissociation in the AΣu+2 state. The predissociation lifetime is found to be 132±21ps for the 000 vibrational level and 64±10ps for the 010 level. The short lifetime is consistent with the low intensity of the LIF signal especially for the 010-010 hot band.


Meditation is expected to regularize autonomic nervous system and reduce metabolic movement, inciting physical and mental relaxation. A lot of research is being conducted to assess effects of different meditation techniques based on heart rate variability analysis or by observing characteristics of ECG. In this paper, effects of Sahaja Yoga meditation technique are analyzed based on ECG characteristics. For this, a new dataset from a total of 30 meditators and non-meditators recorded over a considerable period of 28 days, is used. The local ECG components like intervals and segments are detected using deep learning architecture. Furthermore, the detected fiducial points are localized and ECG characteristics are measured. Some ECG characteristics showed significant variations for meditators compared to non-meditators. From further results and analysis, it can be easily confirmed that sympathovagal balance is quickly attained and remains shifted to parasympathetic nervous system during meditation which helps not only to prevent stress, anxiety but also to cure cardiovascular diseases.


Abstract A novel laser assisted open atmosphere CVD/pyrolysis technique, for the synthesis of dense, hard nanostructured oxide coatings, has been successfully developed in-house. In this process 0·5 to 2·5 μm size droplets of an appropriate metal organic compound/metal nitrate dissolved in a suitable solvent were transported into a quartz tube, using a carrier gas. To this tube a CW Nd: YAG laser (1064 nm) was coaxially coupled. The laser, upon interaction with the precursor, caused its vaporisation/activation. The activated precursor aerosols and the laser were made to impinge the substrate which is placed at an optimum distance. The activated aerosol reacts with oxygen present in the atmosphere at the laser heated spot on the substrate surface to give an oxide coating. Nanostructured alumina coatings were synthesised on steel substrates using aluminium acetylacetonate in ethanol as well as aluminium nitrate solution as the precursors. YSZ coatings were produced using zirconyl and yttrium nitrate mixture (Zr∶Y = 4∶1) precursor solution.