Much forecasting is done by experts, who either make the forecasts themselves or who do opinion research to gather such forecasts. This is consistent with previous knowledge management research that typically has focused on directly soliciting knowledge from those with greater recognized expertise.

However, recent research has found that in some cases, electronic markets, whose participants are not necessarily individual experts, often have been found to be more effective aggregated forecasters. This suggests that knowledge management take a similar tact and expand the perspective to include internal markets. As a result, this chapter extends the use of internal markets to be included in knowledge management, thus expanding the base of knowledge to gathering from nonexperts.

In particular, in this paper I examine the use of human expertise and opinion as a basis to forecast a range of different events. This chapter uses a "knowledge distribution grid" as a basis for understanding which kind of forecasting tool is appropriate for particular forecasting situations. We examine a number of potential sources of forecast information, including knowledge acquisition, Delphi techniques, and internal markets. Each is seen as providing forecasting information for unique settings.


Many motorcycles are now fitted with disc brakes; these have advantages of simplicity and fade resistance but can be dangerously inconsistent when wet. Using a simple braking distance measurement technique a number of possible solutions to this problem have been examined, including the use of various disc and pad materials and treatments to them. None was found to be effective apart from the use of sintered metal pads which gave substantially consistent results, wet or dry. A wet brake test which would elimiate unsatisfactory installations has been proposed as part of the European type approval system and some suggested test methods and parameters have been examined; the importance of the choice of realistic levels of braking and brake watering rates in identifying unsatisfactory materials is highlighted. (Author/TRRL)


Aim: Transurethral resection of prostate (TURP) is still the gold standard in the surgical treatment of benign prostatic hyperplasia (BPH). Urinary tract infection is an unwilling complication after the procedure. The aim of this study is to evaluate the risk factors which are responsable for the occurrence of nosocomial urinary system infection (NUSI) after TURP. Material and Method: A total of 175 patients with a mean age of 67.5±14.1 years ( ranged from 49 to 87 years) underwent transurehral prostatectomy for BPH in between January 2008 and June 2009. After the patients were divided two groups as NUSI and non-NUSI, Analyzse of the clinical parameters of preoperative PSA, previous prostate biopsy, operation time, resected tissue weight, hospitalization period and preoperative catheterization with the nosocomial urinary system infections was done. Results: NUSI was found in thirty-four (19.4%) patients. Preoperative catheterization (p=0.01) were found as the statistically significant risk factors in the group with nosocomial USI. There was no statistically significant correlation between the PSA, prostate biopsy, operation time, hospitalization period and resected tissue weight with the development of postoperative NUSI. Discussion: The patients with catheterization who are candidates of transurethral prostatectomy for the treatment of BPH should be examined detaily preoperatively period. Especially the patients who were preoperative catheterization should be followed up after the treatment for postoperative infection.


Protein targeting and sorting is accomplished by complex vesicular transport processes that are tightly regulated within a cell. This is especially important for epithelial cells because correct delivery of newly synthesized proteins as well as recycling and sorting of internalized membrane proteins is essential for the establishment and preservation of cellular polarity. Many transport events, linking various subcellular compartments, have been analyzed, but many transport mechanisms still remain unresolved. In this study we attempted to identify proteins specifically associated with distinct organelles in murine mammary epithelial cells (EpH4). We isolated subcellular compartments by continuous sucrose gradient centrifugation in order to further analyze their protein composition by high‐resolution two‐dimensional gel electrophoresis (2‐DE). The successful separation of late endosomes (LE), early endosomes (EE) and most of the rough endoplasmic reticulum (RER) was confirmed by subsequent analysis of gradient fractions for compartment‐specific enzymes and marker proteins. Both Golgi and plasma membrane (PM) were found to partially co‐purify with EE in such gradients. Characteristic polypeptide patterns were revealed on 2‐DE gels for fractions enriched in membranes of different origin. Based on improved sample preparation and loading techniques (this issue, C. Pasquali et al., Electrophoresis, 1997, 18, 2573–2581), we were able to identify several proteins by immunoblotting or microsequencing of Coomassiestained spots. This will be the basis for a further characterization of organellespecific molecules in epithelial cells as well as for the establishment of a 2‐DE reference map of membrane proteins from murine mammary epithelium.


Objective To investigate the effect of cordycepin on the expression of p53 gene and the growth,cell cycle and apoptosis of MDA-MB-231 cells.Methods The methyl thiazol tetrazolium (MTT) assay was applied to explore the impacts of cordycepin on the proliferation of MDA-MB-231 cells.After MDA-MB-231 cells were cultured with cordycepin (2,20,40,80,160 mg/L) for 48 h,the cell apoptosis rate and cell cycle were analyzed by flow cytometry.Immunocytochemistry was used to detect the protein expression of p53.Results Cordycepin could inhibit the growth of MDA-MB-231 cells in a dose-dependent manner,and there was the strongest effect in 80 mg/L concentration.Flow cytometry revealed cordycepin could increase the cell apoptosis rate,and there was significant difference between 40 mg/L (11.23 ±0.98),80 mg/L (15.21±2.01) and 160 mg/L (13.27 ±2.26) groups vs control group (3.25 ±0.12,P<0.05),and the proportion of MDA-MB-231 cells in S phase and G2/M phase was gradually decreased but increased in G1 phase after culture with cordycepin (2,20,40,80,160 mg/L)for 48 h.Immunocytochemical results indicated that the p53 protein expression level in MDA-MB-231 cells was gradually reduced with the increase of the cordycepin concentration.Conclusion These results suggest that cordycepin can inhibit the cell growth and induce the cell apoptosis,which may be related to inhibition of the cell cycle and decrease in the expression of p53 in MDA-MB-231 cells.

Key words:
Cordycepin; Breast cancer; Apoptosis; p53 gene


This pathway provides guidance on the imaging of adult patients with lower urinary tract symptoms. Date reviewed: January 2012 Date of next review: 2017/2018 Published: April 2012 Quick User Guide Move the mouse cursor over the PINK text boxes inside the flow chart to bring up a pop up box with salient points. Clicking on the PINK text box will bring up the full text. The relative radiation level (RRL) of each imaging investigation is displayed in the pop up box. SYMBOL RRL EFFECTIVE DOSE RANGE None 0 Minimal < 1 millisieverts Low 1-5 mSv Medium 5-10 mSv High >10 mSv


Abstract We discuss the so-called "simplifying assumption" of conditional copulas in a general framework. We introduce several tests of the latter assumption for non- and semiparametric copula models. Some related test procedures based on conditioning subsets instead of point-wise events are proposed. The limiting distributions of such test statistics under the null are approximated by several bootstrap schemes, most of them being new. We prove the validity of a particular semiparametric bootstrap scheme. Some simulations illustrate the relevance of our results.


Abstract The study assessed the impact of market orientation on performance of small and medium enterprises (SMEs); the mediating role of innovation. The study was conducted on a total of 500 SMEs out of which 391 responses were received representing 78.2% response rate. Purposive and convenience sampling techniques were adopted in selecting the SMEs and questionnaires used to collect data. Explanatory research design was used. The study used Structural Equation Model (SEM) for data analysis and explored various relationships as presented in the hypothesis. The findings indicated that, market orientation variable of customer orientation positively and significantly predict performance; while competitor orientation positively predicts performance; however, not significant. Inter-functional orientation inversely and non-significantly impacts on performance of SMEs in Ghana. Innovation partially mediates between customer orientation and performance. Innovation fully mediates between inter-functional orientations and performance whereas innovation has no mediation between competitor orientation and performance. Businesses, particularly SMEs are encouraged to adopt and embark on market orientation practices and implement innovative practices so as to maximise performance.


The different vulnerabilities of heart and brain to hypotension and hypoxia have been discussed. Hemorrhagic or cardiogenic hypotension appears to cause greater cerebral lesions than drug-induced hypotension. The present model was established to evaluate myocardial blood flow (MBF) and function of the heart and cerebral blood flow (CBF) during tachyarrhythmias and to characterize the capacity of blood flow regulation in the heart and brain during tachycardia-induced borderline hypotension. Methods and ResultsMBF and CBF were determined with radiolabeled microspheres. Coronary and central venous oxygen tensions were measured to estimate myocardial and cerebral oxygen consumption (M&OV0622;o2 and C&OV0622;o2. Measurements were performed in 62 Sprague-Dawley rats during sinus rhythm and high-rate left ventricular pacing and after hemorrhage. In control rats, MBF and CBF were 5.08±1.07 and 1.09±0.29 mL · g−1 · min−1 · MBF increased (7.21±1.98 mL · g−1 · min−1, P < .05), whereas CBF decreased (0.99±0.29 mL · g−1 · min−1, P=NS) during normotensive high-rate pacing. MBF and CBF dropped to 4.27±2.24 mL · g−1 · min−1 (P < =NS) and 0.68±0.29 mL · g−1 · min−1 (P < .05) during pacing-induced borderline hypotension and decreased further during severe hypotension (1.77±0.81 mL · g−1 · min−1, P < .01; 0.45±0.18 mL · g−1 · min−1, P < .01). During borderline hypotension due to hemorrhage, MBF and CBF were 4.05±0.95 mL · g−1 · min−1 (P=NS) and 0.71±0.23 mL · g−1 · min−1 (P < .05). MVo2 and CVo2 were 72.7±15.4 and 12.7plusmn;3.3 mL · 100 g−1 · min−1 in control rats. MVo2 increased during normotensive pacing (100.3plusmn;27.4 mL · 100 g−1 · min−1, P=NS). Mean M&OV0622;o2 was reduced during pacing-induced borderline hypotension (64.1±35.6 mL · 100 g−1 · min−1, P=NS) and severe hypotension (29.8±15.4 mL · 100 g−1 · min−1, P < .05). CVo2 decreased in correlation to CBF. Coronary and cerebrovascular resistance and autoregulation indexes indicated a maintenance of MBF regulation and a failure of CBF regulation during borderline hypotensive tachycardias. These results show a dissociation of MBF and CBF after onset of hypotensive tachycardias. Thus, brain tissue appears to be jeopardized at an earlier stage than myocardial muscle during tachyarrhythmias. ConclusionsThe proposed hypotension model is suitable to analyze tachyarrhythmia-induced hemodynamic changes and end-organ perfusion in the presence of myocardial dysfunction. It has the potential to test therapeutic strategies in the treatment of tachycardias.


Stream channel degradation and aggradation are significant hydraulic problems at river crossings. Degradation is lowering of the streambed, independent of scour caused by obstructions or constrictions. Rapid or long-term degradation is usually due to a significant change in normal sediment-transport relations. Aggradation is stream infilling and occurs when more sediment is supplied to a stream than the stream is capable of transporting. Problems caused by stream degradation are far more common than those caused by aggradation. If actions are to be taken to protect a highway crossing against grade changes, early recognition of these hazards is imperative. Techniques for determining whether a crossing is experiencing degradation or aggradation are observation of stream characteristics (geomorphology), anticipation of gradation changes based on watershed activities, and measurement of pertinent stream dimensions. Streams in areas of high sediment yield are most prone to grade changes. Severe grade changes are often due to human intervention in natural stream processes. The problems associated with degradation and aggradation warrant special attention because protective measures effective against local hydraulic hazards are ineffective for protection against grade changes. (Author)


Background: Two powerful hormones are produced by thyroid gland, thyroxine (T4) and triiodothyronine (T3). These hormones control all metabolic processes and influence oxygen consumption in nearly all tissues of the body.
Objective: To determine the frequency of various thyroid disorders and association of thyroid disorders with age.
Methods: A retrospective descriptive study was conducted at Chemical Pathology and Immunology department, of a tertiary care hospital Lahore, Pakistan from October 2020 to April 2021. Reports of thyroid function test (TFT) of patients from 1st October 2020 to 31st December 2020 were included. Thyroid profile includes three parameters i.e. thyroid stimulating hormone (TSH), free T3 and free T4. Frequency of thyroid disorders was determined according to age and sex. Chi-square was used to determine association between age-groups and vice versa.
Results: Among 239 thyroid profiles of patients, 146 (61%) were found to be within normal range, whereas thyroid profile of 93 (38.9%) patients was disturbed, and they had various thyroid disorders. Frequency of thyroid disorders were significantly associated with age (p value=0.03). Among the patients with disturbed thyroid profile TSH was low in 14 (15.1%) patients and high in 57 (61.30%).
Conclusion: More than one-third of the suspected patients were found to have thyroid disorder. Thyroid disorders were significantly associated with age. Thyroid dysfunction was more common among female patients and presentation of hypothyroidism was more common among after 30 years of age


The empirical study highlights at examining the occupational stress related coping strategies adopted by special educators in inclusive classroom. Inclusive education is an idea in the field of education. It means that persons with disabilities or persons who need special care can learn in schools together with people who do not have special needs. However, inclusive education may make special aid, care or knowledge for persons with disabilities difficult if enough reasonable accommodation is not given. At this juncture, the teachers working in inclusive education need to be competent to handle children with special needs. Because of their commitment and competence they are under pressure and experience stress in inclusive educational settings.  Occupational Stress is a term refers to ongoing stress related to workplace. It is a physical or psychological disorder associated with an occupational environment and manifested in symptoms such as extreme anxiety, or tension, or cramps, headaches, or digestion problems. Sometime the stress also acts as a motivator to the individual to strive for excellence. It is a pressure experienced by the responsibilities assigned in their duty. Such pressure is highly experienced by the teachers working in the inclusive schools with diverse group of learners. In the present study the investigator aimed to study the occupational stressors and the coping strategies of special teachers with special reference to inclusive education. Explorative cum experimentation was adopted in the present study. To collect the quantitative data, the occupational Stress and occupational stress related coping strategies tool was developed by investigators. The investigator designed stress related coping strategies focusing on physical well being, psychological well being, emotional well being and social well being. Stress related Coping Strategies were designed and adopted by the investigator for a period of 4 weeks and its effect was assessed. The study result shows that the special teachers experience occupational stress and the designed Stress related coping strategies were found to be effective. The study evinced the need to incorporate the coping strategies to reduce the occupational stress among teachers to implement inclusive education successfully. It is a need of an hour to incorporate the coping strategies in the teacher education curriculum which in turn develop the pre service teachers to get prepared to face the challenges of inclusive education.


SUMMARY Changes of sucrose metabolism in the subtending leaf to cotton (Gossypium hirsutum L.) boll at different fruiting branch nodes (FBN) were investigated. Two cotton cultivars, Kemian 1 and Sumian 15, were grown in the field at three planting dates in 2009 and 2011. Cotton planted on different dates but experiencing similar climatic factors flowered on the same date and had similar boll opening dates, but had different FBN. In the present study, boll weight and carbohydrate content were significantly affected by both flowering date (FD) and FBN. However, only cystolic fructose-1,6-bisphosphatase (cy-FBPase) and sucrose-phosphate synthase (SPS) activities of the sucrose-metabolizing enzymes were influenced significantly by FBN, and the influence of FBN was lower with delayed FD. In general, effects of FBN on boll weight and sucrose metabolism in the subtending leaf were higher at the optimal FD (13 August) than those at later FD (9 September 2009 and 2 September 2011), and total fruiting branches were used to characterize cotton physiological age in the current study. Sucrose transport capacity (Tn) and SPS in the subtending leaf had significantly positive correlations with boll weight at 17–24 days post anthesis (DPA), a crucial period when boll weight was significantly affected. In addition, higher SPS activity was favourable for sucrose export and boll weight during boll development.


The alkoxides [Be(OCMe2Et)2]3 and [Be(OCMeEt2)2]3 are trimeric in benzene like the tertiary butoxide. The dimer [Be(OCEt3)2]2 has been prepared by a new route. All these give rise to dimeric alkoxyberyllium chloride–tetrahydrofuran complexes, and one gives the complex Cl2Be3(OCMe2Et)4. Beryllium t-butoxide forms no adducts with ammonia, dimethylamine, tri- or tetra-methylethylenediamine, or pyridine, but 4-dimethylaminopyridine gives Me2NC5H4NBe(OBut)2. It forms a compound, Me3AlBe3(OBut)6, on reaction with trimethylaluminium, but the structure of this is not known. Beryllium 2,6-di-t-butylphenoxide is monomeric in benzene, and is unique in this respect.


Current typical content-based publish/subscribe systems (CPS) are not efficient in subscription processing or event matching. This paper presents hybrid content-based publish/subscribe system (HCPS), a novel CPS which joins predicate indexing and testing network approaches. We put subscription coverage mechanism, which are separated from testing network structures, into predicate indexing mechanism to sustain efficient matching, whilst adding, deleting and changing large number of subscriptions. Finally, experiments and performance analysis show that HCPS significantly improve throughput of event propagation and reduce response time to subscription updates.


Currently, in Mexico exist problems for the handling, storage and transport of agricultural residues.
In order to solve the great abundance and low density of these materials, the densification process is proposed
as a solution. Some current machines use the extrusion principle, however, before selecting or designing these
machines, it is necessary to know the mechanical behavior of the material. Thus, the main objective of this
work was to determine the optimal parameters of the densification of fibrous materials.
The tested material was food for ruminants made up mainly of crop residues. Initially, a fractional factorial
design, 25-1, was run to find the most important factors, which were moisture content, temperature, compaction
pressure and size of particles by assessing the responses, density, durability and specific power consumption.
As a result of the statistical analysis, factor relaxation time was neglected to be less significant. With the four
remaining factors, a second order central composite design was run to obtain the functions of the responses.
Afterwards, an optimization method allowed to find the following optimum responses: 657 kg/m3 of density,
95% of durability and specific power consumption of 7 J/g; and optimum levels of the factors: 14.87% of
moisture content, 115oC of temperature, 32.88 MPa of pressure and size of particles of 3/8 in. brief methods,
quantitative results, and the significance of your findings.


The mechanism of myocardial stunning has been studied extensively in rodents and is thought to involve a decrease in Ca2+ responsiveness of the myofilaments, degradation of Troponin I (TnI), and no change in Ca2+ handling. We studied the mechanism of stunning in isolated myocytes from chronically instrumented pigs. Myocytes were isolated from the ischemic (stunned) and nonischemic (normal) regions after 90-minute coronary stenosis followed by 60-minute reperfusion. Baseline myocyte contraction was reduced, P <0.01, in stunned myocytes (6.3±0.4%) compared with normal myocytes (8.8±0.4%). The time for 70% relaxation was prolonged, P <0.01, in stunned myocytes (131±8 ms) compared with normal myocytes (105±5 ms). The impaired contractile function was associated with decreased Ca2+ transients (stunned, 0.33±0.04 versus normal, 0.49±0.05, P <0.01). Action potential measurements in stunned myocytes demonstrated a decrease in plateau potential without a change in resting membrane potential. These changes were associated with decreased L-type Ca2+-current density (stunned, −4.8±0.4 versus normal, −6.6±0.4 pA/pF, P <0.01). There were no differences in TnI, sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), and phospholamban protein quantities. However, the fraction of phosphorylated phospholamban monomer was reduced in stunned myocardium. In rats, stunned myocytes demonstrated reduced systolic contraction but actually accelerated relaxation and no change in Ca2+ transients. Thus, mechanisms of stunning in the pig are radically different from the widely held concepts derived from studies in rodents and involve impaired Ca2+ handling and dephosphorylation of phospholamban, but not TnI degradation.


The space radiation dose rates at several points in Miyagi prefecture and their time dependencies were measured. Radiation exposure was mainly caused by 131I at the earlier stage of Fukushima first nuclear power accidents and then by 134Cs and 137Cs. We inspected radioactive contamination for food produced in Miyagi prefecture and Fukushima city. As the result, almost all food were safe.


This study aims to analyze how the condition of process quality in the manufacture of "shoulder" as one of the spare parts of railroads in Indonesia. The methodology used is quantitative research with naturalistic alignment, process dictation tool is statistical quality control with p control chart and to analyze correlation between disability effect using Pearson correlation regression with 99% confidence level. The data analyzed were 66,655 pcs produced from July to December 2016. Based on the results of the study, six types of disabilities were found in each stage of the process ie early frozen disability, sand inclusion, slag inclusion, dimensions, air cavity deficiency and Mold Defects. From the control chart on each type of disability indicates that the process is out of control, with data always outside the upper control limit and lower control limits. The data also indicate a very significant relationship and influence between the defects occurring in the initial process of defects in the subsequent process. Thus the management must make efforts to work hard to investigate the cause of uncontrolled process, which is suspected due to engine factors, raw materials and also weak control. Subsequent research is proposed to examine it in more detail so that management can take precautions.


Introduction : Civil Society in British History: Paradigm or Peculiarity? 1. From Richard Hooker to Harold Laski: Changing Perceptions of Civil Society in British Political Thought 2. Central Government 'Interference': Changing Conceptions, Powers and Concerns, c.1700-1850 3. 'Opinions Deliver'd in Conversation': Conversation, Politics, and Gender in the Late Eighteenth Century 4. Civil Society by Accident? Paradoxes of Voluntarism and Pluralism in the Nineteenth and Twentieth Centuries 5. Civil Society in Nineteenth-Century Britain and Germany: L. J. M. Ludlow, Lujo Brentano, and the Labour Question 6. Altercation over Civil Society: The Bitter Cry of the Edwardian Middle Classes 7. Public or Private Ownership? The Dilemma of Urban Utilities in London and New York 1870-1914 8. British Progressives and Civil Society in India 1905-1914 9. Military Service Tribunals: Civil Society in Action 1916-1918 10. The Countryside, Planning, and Civil Society 1926-1947 11. Women and Civil Society: Feminist Responses to the Irish Constitution of 1937 12. Civil Society and the Clerisy: Christian Elites and National Culture c.1930-1950 13. 'Simple Solutions to Complex Problems': The Greater London Council and the Greater London Development Plan 1965-1973 14. Civil Society and the Good Citizen: Competing Conceptions of Citizenship in Twentieth-Century Britain Bibliography Index


* Grateful acknowledgement is made to Ir. Wirasmanto M.Sc, Mr Avontroodt and Mr Wurdack for helpful comments on an earlier draft, and to Ir. Muhafzan and Mr Avontroodt for providing statistical information. Computations were carried out on a Hewlett Packard 9820A programmable calculator.


Art colleges have their own advantages in using"red classic plays"in political course teaching,which is mainly due to in the following three aspects: the social environment factors,the campus environment factors and college students' main body factors. Through the organic integration with classroom,building red classical repertoire,red classic campus performance etc,the actual effect of ideological and political education in art colleges is improved.


Based on the daily precipitation data of the Huai River basin (HRB) and NCEP/NCAR reanalysis data from 1960 to 2014, the study examines the spatio‐temporal characteristics of summer extreme precipitation (SEP), explores the statistical relationship between the changes of SEP in the HRB and the East Asian summer monsoon (EASM), and further investigates the circulation characteristics which are most conducive to extreme precipitation under different EASM backgrounds. The main results are as follows: (a) summer extreme precipitation indices (SEPI) of PNL90 and PQ90 mainly increased (although not significant) in the HRB from 1960 to 2014, and the weakening of EASM may be the reason for the upwards trend. (b) The characteristics of SEP are quite different between the north and the south of the HRB, and SEPI mainly negatively correlates with East Asian summer monsoon index (EASMI) in the south but positively correlates in the north. (c) Extreme precipitation may occur under both strong and weak summer monsoon backgrounds in the HRB, but the circulation configurations are different. The differences between high and low SEP are mainly associated with the intensity of western Pacific subtropical high (WPSH) for the weak EASM years, while the differences mainly lie in the position of WPSH for the strong EASM years.


We consider ballistic transport through a lateral, two-dimensional superlattice with experimentally realizable, sinusoidally oscillating Rashba-type spin-orbit interaction. The periodic structure of the rectangular lattice produces a spin-dependent miniband structure for static SOI. Using Floquet theory, transmission peaks are shown to appear in the mini-bandgaps as a consequence of the additional, time-dependent SOI. A detailed analysis shows that this effect is due to the generation of harmonics of the driving frequency, via which e.g., resonances that cannot be excited in the case of static SOI become available. Additionally, the transmitted current shows space and time-dependent partial spin-polarization, in other words, polarization waves propagate through the superlattice.


Based on steelmaking process of electric arc furnace,an integrated control system is proposed,which is composed of industrial computer and programmable logic controller(PLC).The industrial computer is used for data management and calculation of material set value,and the PLC is applied to control equipment action and deal with related signals.On the basis of analyzing and calculating control method on variety burden,the subprogram of weighing control is designed.The running results show that the system is stable and reliable which has high control accuracy and production efficiency.


The intensification of consumers' concerns for personal health protection has conducted, among other things, to a change in purchasing behavior toward organic food. However, emerging markets are still characterized by low levels of organic food consumption. Therefore, companies present on this market are trying to find new ways to boost the consumption of organic food, along with placing their brands in the most favorable positions in the minds of consumers. This study aims to identify the positioning bases that companies want to highlight in order to outline the desired position of their brand. To achieve this goal, a qualitative research was conducted among producers/processors, distributors/importers, and retailers having organic food brands in their portfolio. The results of the research showed the focus of the companies on highlighting the attributes related to the product characteristics and the personal green benefits, at the expense of environmental, emotional, and symbolic benefits. Positioning bases related to consumption occasions, brand values, and association with fictional characters or celebrities play a secondary role in supporting the brand position. The research contributes to the classification and conceptualization of specific positioning bases for organic food brands, providing an overview of this topic at the supply chain level.


This qualitative self-study explores teaching practices that have been proven to assist teachers in making the general education curriculum challenging for advanced readers in their classrooms. It discusses who advanced readers are, evidence-based practices to teach gifted/advanced readers, and a reflective dialogue on one teacher's utilization of multiple strategies.


This paper reports the findings of a narrative study on language student teachers' epistemological re-configurations through lesson planning in a private university in Bogota, Colombia. The study aimed at exploring the possible forms of professional yet personal–local knowledge two language student teachers encounter and produce when they plan language lessons. We employed the life story interviewing to gather information on the subjective essence of the participant's experiences in their teacher practicum. Findings suggest that through lesson planning, language student teachers manage to re-signify certain methodological yet hegemonic constructions of teaching and learning. Furthermore, their knowledge of themselves as teachers in relation to their practicum is shaped by circumstances they face in the process of planning and teaching lessons.


ATP levels of three marine isolates (a Vibrio sp., Serratia marcescens, and an unidentified rodshaped organism) were measured during nutrient-limiting conditions for free-living bacteria or cells adhered to a glass/liquid interface. In all strains there was a higher content of ATP per biovolume (numbers × cell volume) for cells starved at the glass/liquid interface compared with those in the bulk phase. Leakage from viable cells and the formation of a conditioning film are suggested only partly to explain the elevated levels of ATP per biovolume at the surface.


The emerging techniques in the medical field include the use of bio implantable antennas to diagnose the diseases. The major disadvantage of these techniques is the side-effects caused by the radiations in the human body. There have been a lot of advancements in this area to reduce the radiation emitted. One among them is the use of PIFA antenna inside an indestructible capsule (Polyetheretherketones) which is helpful in both short and long range communications. The work includes the design of PIFA antenna using IE3D and MATLAB software. The characteristics of the antenna are analyzed with the aim to reduce the size and radiation effect of antenna and to increase the gain, efficiency and data rate.


Green energy plays a vital role in our day today economic life for the future reforms of the world. This proposal is a venture in refrigeration and Air conditioning systems where waste heat is used at an efficient manner. Hence vapor compression cycle makes the basic principle behind refrigeration and air conditioning systems. Moreover, the world energy crisis has led to the utilization of waste heat, solar energy, bio energy, wind energy etc. for the functioning of some of refrigeration systems. This proposal is a concerted for various government and private agencies to develop eco energy in the commercial environment by grooving the requirements of refrigeration and decreasing the dependence on conventional energy resources .This proposal mainly enhances in waste heat recovery in Refrigeration and Air Conditioning systems. With a single input from the compressor we extract three efficient outputs viz. 1) Hot water 2) Cold Water and 3) Air Conditioning. The refrigerant used in the component is R290 blended with R134a which is equivalent to R22. An evaporative cooler produces effective cooling by combining a naturals process water evaporation with a simple, reliable air moving system evaporative coolingis the most economical and effective means of refrigeration and air cooling since its inception particularly in the areas where climatic conditions are hot and dry. The energy saving by doing so is saved more than 30 W. It is referred as a small size Desert cooler.


Winner's Curse refers to the situation where the auction winner curses after winning the auction through overestimating values of the auction items for ownership acquirement because of the inconformity does exist between their previous expectation and the actual value. It is common that winner's curse happens in the auction business assets, mergers and acquisitions, gaming, investment decision-making and other fields. Winner's curse can be explained by the loss aversion, overconfidence theory and meanwhile affected by the uncertainty of the auction goods' value, the number of bidders, information and lessons learned, etc. Effective strategies for responding to the winner's curse contain the joint bidding strategy, information sharing and learning more cautious. Future research on the winner's curse needs to explore the psychological mechanism, research paradigm and localization issues.


The utility model relates to an automatic smoke exhaust ventilator, comprising a smoke exhaust ventilator and a control circuit. The control circuit is composed of a sensor, a central processing unit and a drive circuit. The sensor is a sensor of temperature induced circuit which is composed of a thermal resistor and a capacitor, and also a sensor of induced circuit of infrared ray or far infrared ray. The utility model is provided with a power-ON indicating circuit, a operating warning circuit, a lighting circuit which combines a human body sensing circuit and an optical control circuit, and a time display circuit. The utility model has the advantages of intelligent control, steady performance and easy use.


Many branches of mathematics come together in harmonic analysis, each adding richness to the subject and each giving insights into this fascinating field. Devito's Harmonic Analysis presents a comprehensive introduction to Fourier analysis and Harmonic analysis and provides numerous examples and models so that students leave with a clear understanding of the theory.


Summary Ehrlich ascites and Gardner lymphosarcoma tumor cells were employed to induce ascites fluid formation in mice. Two strains of mice injected with antigens (Xp-human γ-globulin, myosin, ovalbumin) mixed in Freund's adjuvant had the capacity to respond with antibody production. The antibodies developed to Xp-human γ-globulin reacted with the hapten portion as well as normal human γ-globulin. The mouse anti-human myosin serum behaved similarly to the rabbit anti-myosin serum when studied by the immunohistochemical method.


We describe use of swept-wavelength interferometry for distributed fiber-optic strain and temperature sensing in single mode and gradient index multimode fiber. The method is used to measure strain in a four-strand multimode cable under twist.


1089 Figure 1 Abstracts Int J Gynecol Cancer 2021;31(Suppl 3):A1–A395 A137 on S etem er 5, 2023 by gest. P rocted by coright. http/ijgc.bm jcom / nt J G ynecol C acer: frst pulished as 10.11ijgc-2021-E S G O .28 on 12 O cber 221. D ow nladed fom cardiac surgeons, pathologists, oncologists and cardiovascular anesthesiologists were involved. A complete trans-thoracic echocardiogram was performed, showing an isoechoic, mobile, adherent to the tricuspid ring, 22 x 50 mm mass with nonsmooth margins, resulting in obstruction of the right ventricular filling (gradient 7 mmHg). Cardiac magnetic resonance imaging (MRI) demonstrated a 41x35 mm, polylobed mass, adhered to the tricuspid ring on the inferior-posterior side, which incorporated the posterior and septal flaps of the tricuspid valve, extensively emerging in the ventricular cavity in the diastolic phase. The mass obstructed the right ventricular filling and its most caudal portion partially occupied, in the systolic phase, the outlet of the inferior vena cava in the atrium. Because of the life-threatening obstruction, the mass was removed by cardiac surgeons with sternotomy in extracorporeal circulation. During surgery, the mass was analyzed by pathologist, confirming the endometrial origin. Postoperatively, radiotherapy (RT) on the heart was performed, followed by second line CHT with Liposomal Doxorubicin till February 2021. Result(s)* In February 2021 cardiac MRI was performed, showing no evidence of disease. Complete response of the oropharyngeal and abdominal recurrences was also detected. But the woman presented with neurological symptoms, as partial paralysis of the legs. Encephalic MRI was performed showing brain metastases. The woman underwent pan-encephalic RT with subsequent reduction of those lesions. In June 2021, the woman is still alive without neurological nor other symptoms. Conclusion* A multidisciplinary approach is essential to treat rare EC metastases. Reference centers for the treatment of EC must have specialists from other disciplines available, to ensure the best clinical practice. 1093 OPTIMISING OUTCOMES FOR LAPAROSCOPIC HYSTERECTOMY IN PATIENTS WITH MORBID OBESITY E Van der Zanden, F Testa, C White, P Larsen-Disney, F Drews, S Kaushik, S Baron*. University Hospitals Sussex NHS Foundation Trust, Gynaecological Oncology, UK 10.1136/ijgc-2021-ESGO.229 Introduction/Background* Operating on patients with a significantly raised body mass index (BMI) represents a significant challenge to the surgical and the anaesthetic team. Hysterectomy for early-stage uterine cancer is usually performed via laparoscopy. We aimed to evaluate whether a two consultant 'buddy operating' approach improves on intra-operative and postoperative outcomes in patients undergoing total laparoscopic hysterectomy (TLH) for endometrial cancer who are morbidly obese. Methodology A prospectively selected cohort of 25 patients with a BMI 47-70 undergoing TLH was divided into two groups according to whether the first assistant to the GynaeOncology consultant was a registrar (ST3-7), or a consultant ('buddy operating'). Anaesthetic time, operating time, intraoperative estimated blood loss (EBL), requirement for high dependency unit (HDU) bed and length of stay (LOS) were compared in the two groups. Result(s)* Average 'buddy' operating time was significantly shorter compared to the registrar-assistant group (01:31h vs 01:59h respectively; p<0.001); a similar trend was seen with the average total anaesthetic time (02:48h vs 03:23h respectively; p<0.001). EBL was less in the 'buddy operating' group (39 mls) vs registrar-assistant group (169 mls; p<0.001). Postoperatively, LOS was shorter in the 'buddy operating' group as compared to the registrar-assistant, though not significantly so (1.13 vs 1.59 days; p=0.109). 2 of the total patients (8%) required a one-night stay in HDU for observation due to their co-morbidities, both in the registrar-assistant group. Mean BMI, age, ASA and comorbidities were similar in the two groups. Conclusion* In patients with a significantly raised BMI, TLHs by two consultants vs consultant and registrar are associated with better intra and post-operative outcomes, including reduced overall anaesthetic time, operating time, and EBL. There is an association with a reduced length of overall hospital stay, though this was not significant. 1108 IMPLICATIONS OF OBESITY IN ENDOMETRIAL CANCER MC Tirnovanu*, D Timofte, R Corduneanu, A Crudu, B Scurtu, A Iov, VG Tîrnovanu. University of Medicine and Pharmacy ,,Gr T Popa' , Obstetrics and Gynecology, Iasi, Romania; Clinical Hospital of Obstetrics and Gynecology ,,Cuza Vodă' , Iasi, Romania; University of Medicine and Pharmacy ,,Gr T Popa' , Surgery, Iasi, Romania; Clinical Hospital ,,Sfântul Spiridon' Iaşi, Surgery, Iasi, Romania; Clinical Hospital of Obstetrics and Gynecology ,,Cuza Vodă' , Obstetrics and Gynecology, Iasi, Romania; University of Medicine and Pharmacy ,,Gr T Popa' , student sixth year, Iasi, Romania; University of Medicine and Pharmacy ,,Gr T Popa' , student fourth year, Iasi, Romania 10.1136/ijgc-2021-ESGO.230 Introduction/Background* Over half of the endometrial cancers (EC) are caused by obesity, known as an independent risk factor. In Romania, in the last years the obesity rate had an alarming growth, with many high grade cases that influence the clinical management of the disease, the surgical procedure, radiotherapy planning, and the survival rate. Abstract 1089 Figure 2 Abstracts A138 Int J Gynecol Cancer 2021;31(Suppl 3):A1–A395 on S etem er 5, 2023 by gest. P rocted by coright. http/ijgc.bm jcom / nt J G ynecol C acer: frst pulished as 10.11ijgc-2021-E S G O .28 on 12 O cber 221. D ow nladed fom


NIST is standardizing postquantum cryptography (PQC) algorithms that are resilient to the computational capability of quantum computers. Past works show malicious subversion with cryptographic software algorithm subversion attacks (ASAs) that weaken the implementations. We show that PQC digital signature (DS) codes can be subverted in line with previously reported flawed implementations (2008) (Bernstein et al., 2016) that generate verifiable, but less-secure signatures, demonstrating the risk of such attacks. Since all processors have built-in hardware performance counters (HPCs), there exists a body of work proposing a low-cost machine learning (ML)-based integrity checking of software using HPC fingerprints. However, such HPC-based approaches may not detect subversion of PQC codes. A miniscule percentage of qualitative inputs when applied to the PQC codes improves this accuracy to 98%. We propose gray-box fuzzing as a preprocessing step to obtain inputs to aid the proposed HPC-based method.


Based on the literature review of the rural financial efficiency,the definition and effecting factors of rural financial efficiency has been discussed,and the evaluation framework of it has been analyzed as well.To fill the research gap,the content of rural financial efficiency has been developed in the paper.And the efficiency growth way has been discovered from both the operating performance perspective and service performance perspective.


Background

Corded and hyalinized endometrioid carcinoma(CHEC) is a rare morphological variation of endometrioid carcinoma(EC) in the endometrium. Reports of CHEC were very limited. We represent the clinical and pathological findings of this rare endometrioid carcinoma in a 26-year-old woman and reviews the literatures updated on CHEC.
Case presentation:

A 26-year-old woman presented with abnormal vaginal bleeding for 3 months and the initial cervical biopsy revealed a mullerian mixed tumor in another clinic. Abdominopelvic computed tomography revealed a mass in the uterine cavity and cervix, suggesting a malignant tumor. Histologically, the tumor showed a biphasic pattern characterized by an appearance of 2 components, the conventional endometrioid carcinoma component and sex cord-like component with hyalinization. In the areas of sex cord-like elements, the epithelioid and spindle cells were usually seen around the glands, and mostly arranged in cords or trabeculaes, sometimes embedded within a richly hyalinized collagenous or sometimes myxoid matrix. Tumor cells in the sex cord-like region show a different immunohistochemical expression pattern from conventional adenocarcinoma. Cytokeratin(CK) and vimentin are positive in both components, and vimentin shows more diffuse positivity while CK is more restricted and focally expressed in tumor cells in the sex cord-like region. Complete loss of expression of E-cadherin and epithelial membrane antigen(EMA) was seen in tumor cells in the sex cord-like region whereas it was well preserved in the area of conventional adenocarcinoma. Nuclear expression of β-catenin was noted in tumor cells in the sex cord-like region. P53 was focally positive in both components. Based on histological and immunochemical examinations, the patient was diagnosed with CHEC.
Conclusions

CHEC is not uncommonly mistaken for a wide variety of diseases. It's of great significance to raise the awareness of CHEC to avoid over-treatment caused by over-diagnosis, especially in young patients and in curettage. We report one case of CHEC in a 26-year-old woman which was misdiagnosed as a mullerian mixed tumor in the initial curettage specimen. The clinicopathologic, light microscopic, immunohistochemical features of this tumor are described and the differential diagnosis is discussed.


Aims: To optimize the culture media of 0288 Tricholoma matsutake and to identify it according to its rDNA ITS sequence. Methods: Fruit body, collected from Heilongjiang province, is used as the material, and the mycelium is isolated and radiated under ultraviolet. Then the radiated mycelium is cultured in five different media and its morphology of fungus colony and growth rate are investigated. After that, the rDNA ITS sequences of 0288 and the natural fruit body of T. matsutake are analyzed and identified by PCR and sequencing. Results: The radiated mycelium grew faster in formula A culture medium than others and its average growth rate is up to 0.575mm/d. Results also showed that the homology of the rDNA ITS sequence is almost up to 99% between 0288 and the natural fruit body. Through this experiment, the best growth condition of 0288 is obtained and its fruit body is induced as pure cultural product. It would lay strong foundation for the artificial domestication of the wild T. matsutake.


This paper first establishes the fact that literary texts occupy a significant place in the teaching of translation. It then proceeds to trace some of the routes taken by one group of post-secondary learners in translating literature. From this two translator types emerge: the active learner and the passive. Such a distinction proves to be more than a matter of convenient labelling. As the paper will attempt to demonstrate, it has implications for both the practice and pedagogy of translation, particularly relevant to the literary variety. Among other things, it echoes the all-important contrast between two concepts: grammaticalness of sentences versus communicativeness in discourse. The vehicle for this study is a literary text translated from English into Modern Standard Chinese.


The limitations of the Primary Prevention Program (PPP) diabetes substudy have been previously discussed in the original article (1) and in the accompanying editorial (2). Nevertheless, the comments of Dr. de Gaetano (3) require some important additional considerations.

1 ) The results of the substudy are not the outcome of a post hoc analysis, since an oversampling of diabetic patients was planned before the study started to specifically explore the role of aspirin in these patients.

2 ) Dr. de Gaetano suggests that the lower-than-expected effect of aspirin could have also emerged if other subgroups, namely patients with hypertension or hypercholesterolemia, would have been examined. This is not the case—aspirin was effective in reducing the risk for total cardiovascular events in both subgroups …


General aviation is an underutilized transportation mode, particularly when compared to alternative modes such as the automobile and the commercial airlines. In this research, barriers to the utility of general aviation were identified through a web-based survey of active general aviation pilots, with 1,471 surveys returned and suitable for analysis. The survey data indicated five key barriers which were thought by pilots to be currently reducing their ability to utilize general aviation transportation to its fullest extent: weather, expense of the travel mode, a lack of mobility at the destination, doorstep-to-destination travel time, and reduced access to general aviation transportation. A mode choice model was also constructed to further examine some of these barriers, including travel expense and doorstep-to-destination travel time. While the model considered only key quantitative factors such as travel distance, time and the travelers' value of time, it proved to be quite powerful in demonstrating how general aviation utility is affected by changes in the key factors. From the survey data, and analysis with the mode choice model, several key issues emerge as being important to increasing the utility of general aviation transportation. Improved weather information, including real-time information in the aircraft cockpit, as well as near all-weather capability for general aviation aircraft and better access to ground transportation at the travel destination would significantly increase utility. Furthermore, modifying the business model for owning and operating general aviation aircraft may be the best near-term strategy for lowering the expense of general aviation transportation. Analysis with the mode choice model also indicates that increasing the speed of general aviation aircraft will not necessarily translate into an increase in the utility of general aviation transportation. Thesis Supervisor: R. John Hansman, Jr. Title: Professor of Aeronautics and Astronautics


Abstract Introduction Calcium is a mineral that is required for nearly every cell in the human body to operate properly. Calcium homeostasis is mediated by active vitamin D (calcitriol) and parathyroid hormone (PTH) on calcium absorption in the GI tract, calcium excretion in the kidney, and osteoclast/osteoblast activity in the skeleton. Under normal settings, PTH promotes bone production and resorption by increasing the number of osteoblasts and, as a result, indirectly increasing the number of osteoclasts. Hypocalcemia, a decrease in extracellular calcium defined as serum total calcium < 8.5 mg/dl corrected for serum albumin. Hypocalcemia is caused by a lack of vitamin D (which can lead to secondary hyperparathyroidism), abnormal phosphate or magnesium levels, and partial or complete hypoparathyroidism. Hypocalcemia was found to be present in 1.6% of cases of cancer. We present a patient with prostate cancer and severe hypocalcemia, predominantly due to extensive osteoblastic metastases. Clinical case: A 42 y/o Male with prostate cancer metastases to bone and lymph Nodes developed severe hypocalcemia and hypophosphatemia during the course of treatment. Patient was treated aggressively with per oral (PO) and intravenous (IV) calcium and phosphorous supplementation with no significant improvement in the values. Vitals were stable except for a heart rate of 101 beats per minute. The physical exam was normal. Labs: Calcium-5.1 mg/dl(8.5-10.1), Ionized calcium-0.74 mmol/L(1.2-1.38), Albumin-4.2gm/dl(3.4-5. 0),Phosphorous - 0.6 mg/dl(2.5-4.9), Alkaline phosphatase- 1.573 units/l(45-117), Magnesium-1.8mg/dl(1.7-2.4), Vitamin D25 OH-17ng/ml(30-100), PTH-281 pg/ml(18.4-88), Ferritin-725ng/ml(30-300), TSH- 1.45 ulU/ml(0.36-3.74). Imaging: CT scan chest/abdomen/pelvis showed metastatic disease throughout sternum, lumbar spine, pelvis, and proximal femur. MRI thoracic spine showed extensive metastatic disease throughout the thoracic spine. The patient was diagnosed with hypocalcemia in the setting of metastatic prostate cancer due to avid calcium uptake by bone metastasis. The patient was treated with radiation therapy, high dose Vitamin D every week, calcitriol, phosphorous, and labs were closely monitored every month. His labs showed normalized calcium, phosphorous, alkaline phosphatase, and Vitamin D level after eleven months, and his symptoms improved. This improvement was paralleled by a significant improvement in PSA concentrations while on androgen deprivation therapy and chemotherapy for Prostate cancer. Conclusion Hypocalcemia in cancer patients is a rare event. However, it can be life-threatening, so it is essential to rule out other causes by measuring magnesium, creatinine, phosphate, vitamin D, and PTH levels to determine the treatment. Hypocalcemia can occur at any time during therapy, it is most frequently reported within six months of treatment initiation. For patients with a substantial burden in bone (=>three bone lesions), prophylactic calcium and vitamin D are associated with fewer hypocalcemia adverse effects. Patients should be informed about the risk of hypocalcemia and the significance of supplement adherence, serum calcium levels should be checked to assess adherence with close follow-up. Presentation: No date and time listed


This paper considers the story of Shakespeare's Isabella – both within and outwith the narrative of Measure for Measure – as a lens through which to explore representations of the judge and judging. Taking criticisms of Isabella and her encounter with Angelo as its starting point and backdrop, it seeks to trouble the polarisation of justice and care – law and mercy – in traditional accounts of adjudication. Challenging the notion of the judge and judicial impartiality as necessarily unconnected to those she judges, the paper establishes Isabella as an icon – a focus for contemplation and reflection. So viewed, Isabella and her relationships with Angelo, Claudio, Mariana and the Duke, provide a window onto alternative conceptions of autonomy, relationship, justice and care and, in so doing, orientate the mind and imagination toward the re-conceiving of previous insights on adjudication and the possibilities of diverse understandings of the judge, judging and adjudication.


Background: Research into psychotherapy for binge-eating disorder (BED) has focused mainly on cognitive behavioural therapies, but efficacy, failure to abstain, and dropout rates continue to be problematic. The experience of negative emotions is among the most accurate predictors for the occurrence of binge eating episodes in BED, suggesting benefits to exploring psychological treatments with a more specific focus on the role of emotion. The present study aimed to explore the feasibility and efficacy of individual emotion-focused therapy (EFT) as a treatment for BED by examining the outcomes of a pilot randomised waitlist-controlled trial.
Methods: Twenty-one participants were assessed using measures of feasibility (recruitment, credibility and expectancy, and therapy retention), and efficacy (objective binge episodes and days, and binge eating psychopathology). The treatment consisted of 12 weekly one-hour sessions of EFT for maladaptive emotions over three months. A mixed model approach was utilised with one between effect (group) using a one-way analysis of variance (ANOVA) to test the hypothesis that participants immediately receiving the EFT treatment would demonstrate a greater degree of improvement on outcomes relating to objective binge episodes and days, and binge eating psychopathology, compared to participants on the EFT waitlist; and one within effect (time) using a repeated-measures ANOVA to test the hypothesis that participation in the EFT intervention would result in significant improvements in outcome measures from pre to post-therapy and then maintained at follow-up.
Results: Recruitment, credibility and expectancy, and therapy retention outcomes indicated EFT is a feasible treatment for BED. Participants receiving EFT demonstrated a greater degree of improvement in objective binge episodes and days, and binge eating psychopathology compared to EFT waitlist control group participants. When participants in the EFT waitlist control group then received treatment and outcomes data were combined with participants who initially received the treatment, EFT demonstrated significant improvement in objective binge episodes and days, and binge eating psychopathology for the entire sample.
Conclusions: These findings provide further preliminary evidence for the feasibility and efficacy of individual EFT for BED and support more extensive randomised control trials.


Abstract. One of the successful keys to compete in a business is the mastery of information. Marketing jobs in a company is to find the right products for customers rather than to find the right customers for the products. "ProMix" (comes from the term of "Product Mix") is one of some marketing tools to use in order to achieve its marketing objectives in target markets. It assesses the company's operations efficiently to avoid or minimize waste in the organization in the efforts to achieve the goals. Therefore, it is necessary to design a computerized system which, in this study, is called ProMix system. The system can be used to forecast the company's production volume and product distribution. ProMix system is designed and built by using Visual Basic as its programming language and SQL database server. The result is an information system that contributes to the efficiency of company operations and performance management of PT. Danar Hadi Batik Solo in making a decision. Keywords: information system, product mix, product, forecasting, marketing   Abstrak. Salah satu kunci keberhasilan untuk mampu bersaing dalam menjalankan usaha adalah penguasaan informasi. Pekerjaan pemasaran dalam perusahaan bukan untuk menemukan pelanggan yang tepat melainkan menemukan produk yang tepat bagi pelanggan. ProMix (berasal dari Istilah " Product Mix ") merupakan salah satu alat pemasaran yang digunakan perusahaan untuk mencapai tujuan pemasarannya di pasar sasaran. Operasi perusahaan dinilai efisien bila mampu menghindari atau meminimalisasi pemborosan di dalam usahanya mencapai sasaran organisasi. Untuk itu dirancang suatu sistem terkomputerisasi dalam penelitian ini yang disebut Sistem ProMix dan dapat digunakan perusahaan untuk meramalkan volume produksi dan pendistribusian produk. Sistem ProMix dirancang dan dibangun menggunakan Visual Basic sebagai bahasa pemrogramannya dan database SQL Server. Hasil dari penelitian ini merupakan sebuah sistem informasi yang dapat memberikan kontribusi terhadap efisiensi operasi perusahaan dan kinerja manajemen PT. Batik Danar Hadi Solo dalam pengambilan keputusan, sehingga dapat meminimalisasi kerugian perusahaan baik dari segi penjualan produk maupun distribusinya. Kata Kunci: sistem informasi, product mix , produk, peramalan, pemasaran


Direct transaction between large power consumers and power generation enterprises is favorable to optimal configuration of resources as well as cost reduction and raising efficiency,besides,it can also effectively promote the demand on electric power,bring up new economic growth points in industry,economy and demand of electric power,thus it is possible to implement mutual benefit of power generation,transmission and consumption.For this purpose,a direct transaction platform for large power consumers and power generation enterprises is designed.This transaction platform possesses such functions as management of transaction rules,management of transaction process,releasing notices related to transactions and transaction results,so it can meet the demand of direct transaction between generation enterprises and large power consumers.


ing: processing a message with less than complete detail Escape: acting to cut off information input Chunking: transmitting meaningful information in organized "chunks" of symbols rather than symbol by symbol40 To escape threatening inputs, for example, we may simply ignore (consciously or unconsciously) information that contradicts our beliefs or selfimage. Some degree of filtering also seems to be built into the cognitive system, since inputs that do not fit cognitive maps will tend to simply go unregistered. Important in the functioning of all the above homeostatic processes is object-oriented attention. Homeostasis involves a defensive posture towards life, and as Gilbert points out, "The attention structure in defense is focused rather than open."41 This "focusing" correlates with an objectoriented engagement with the world, reflecting the cognitive system's attempts to manipulate "things" in order to maximize safety. Such attention may be directed either externally (on "objects") or internally (on thoughts). It takes the form of a non-reflective immersion in a world of objects that rarely focuses on anything in particular (i.e., it is not concentrative). Instead, it involves a rapid shifting of attention among objects. Fluctuating between the mental and the external and driven by whatever egocentric agenda is at the forefront of consciousness, object-oriented attention is accompanied by a loss of any felt, existential appreciation for the moment. Directed externally, this type of attention reinforces perceptual dualism and the presumption of an ontological distinction between subject and object. As discussed above, one of the self-reinforcing aspects of the mental system is the perceived world itself—being a construction of conceptual constructs, it reflects those constructs back to the system. Object-oriented attention is a central factor supporting this involvement in a constructed world. In doing so, it also operates in conjunction with conceptual conStudstill: Cybernetic Approach to Dzogchen 333 structs that define the "objects" of attention, thereby reinforcing those constructs and the dualistic mode of experience they help generate. Directed internally, it involves attention on the internal narrative (and the forms this narrative may take, such as fantasy) and becomes one of the primary mechanisms regulating evaluative constructs and the self-image in particular.42 Integral to all of these various processes is an overriding self-obsession,43 reflecting once again the self-reinforcing dimension of the system: the concept/experience of self creates an inevitable sense of vulnerability, which encourages self-obsession and the need to protect the self through the processes described above. This in turn reinforces a "self," exacerbating the sense of vulnerability and therefore strengthening attempts to defend the self in a continuous and self-perpetuating cycle. Evolution through Positive Feedback To the extent that safety/meaning is construed according to a conceptual system, disconfirmation is inherently threatening and therefore will tend to be suppressed. However, if disconfirmation (stress) crosses a critical threshold, the cognitive system's ordinary homeostatic mechanisms may be inadequate to suppress the threat. System organization therefore becomes dysfunctional (felt as some form of emotional discomfort) since it is no longer able to maintain a sense of safety or belonging in relation to self-image or environmental circumstances. In response, the system may take one of two courses. Typically, the system will intensify efforts "to rigidly adhere to dysfunctional patterns in an attempt to accommodate the crisis without having to actually change."44 To preserve its constructs, the system may dissociate and close its boundaries even more, either by intensifying constructive processes to support a sense of "personal grandiosity" or by intensifying inhibiting processes (such as increased "emotional withdrawal").45 This initiates the devolution of the system into what may eventually become psychopathological states. The other option is to change constructs—specifically, to evolve one's understanding of life toward a less conditional, less dualistic perspective.46 This takes place through positive feedback, which reorganizes "the existing construct sets to fit the actual stream of sensory experience."47 As Ervin Laszlo explains, "Negative-feedback stabilizing cycles give way to positive-feedback motivated learning cycles when the input fails to match the constructs of the system, or matches then insufficiently."48 Through positive feedback, constructs are allowed to deviate from their steady state in an attempt to evolve a conceptual model that can accommodate threatening inputs. This deviation may increase chaos and stress within the cognitive system, yet ultimately it makes it possible for


patient with recurrent drug-refractory sustained monomorphic ventricular tachycardia. The patient had no previous medical history. He reported that his grandmother had died suddenly at the age of 45 years. The 12-lead ECG in sinus rhythm showed only slight notching of the QRS in leads II, V2 and V3, with normal ending part and no T-wave abnormalities. The transthoracic echocardiogram was unremarkable. More than 21 000 ventricular premature beats with 2 different morphologies were recorded by 24-hour Holter monitoring. Catheter ablation was performed using the EnSite NavX electroanatomic mapping system (St. Jude Medical, Inc., St. Paul, MN, USA). During the procedure, only short bouts of the clinical arrhythmia were inducible in the right ventricular (RV) apex with programmed electrical stimulation with up to 3 extrastimuli. One sustained (but lasting less than 1 min) and several unsustained episodes of a second monomorphic ventricular tachycardia with left bundle branch block morphology were reproducibly induced in the RV outflow tract instead, with the same programmed stimulation pattern. At this point, a suspicion of the presence of undiagnosed ARVD/C was raised.


Few things in academic life are as satisfying as encountering an engaged critique of one's work. In that spirit, I was delighted to read the rigorous and thoughtful replies to my review essay 'A Fifth Generation of Revolutionary Theory?' by Ben Abrams (2019) and, responding to both of us, Colin Beck and Ritter (2021). Their critiques have prompted me both to rethink what I have got wrong–as well as clarify and defend what I still think I have right, as I argue below–and the limitations of the entire exercise of delineating 'generations' of social theory about revolutions. They also do so in ways that open up new directions for the study of revolution: a challenge I seek at least to begin to take up in this brief reply. (Figure 1) There is much common ground between us. In this reply I will focus first on my substantive disagreements with Abram's contention that a fifth generation is yet to come –namely the implicit difference between 'modelling' explanatory variables and identifying interactive processes and a genuinely different object of investigation, both present in his 'long' fourth generation. I then take up Beck and Ritter's advice to turn away from literature reviews and back to developing novel substantive questions that also (as Abrams rightly enjoins us) have some political bearing on the practice and outcomes of revolutions. Taking some issue with Beck and Ritter's claim that the question of the object of study in revolution theory has been settled, I suggest that underlying all of this meta‐ debate is a deeper question: whatever happened to social revolution? I will sketch out the beginning of an answer based on the transformation of agrarian relations in the late 20 century, and the implications of this transformation not just for revolution but for its understudied correlate, counter‐revolution. In doing so, even in preliminary and tentative form, I hope to advance the common project of substantive research on revolutions which this debate has revealed as the common concern amongst its participants.


Recently has appeared different articles that reported the use of microwaves and laser radiation to modify the behavior of biological systems [1-7]. Laser radiation has been applied to stimulate the growth of E. Coli cultures, the DNA replication and division, the activation of some genes and the activation of the growth of some seeds [1, 3-7] between others. It is important to mention that each biological system requires different parameters of radiation for stimulation.


Using sporting applications to make mathematics more interesting to both secondary and tertiary students is often discussed in the literature, eg Clarke (1984,1991), deMestre (1987). Australian Rules Football, being the winter sport followed by most people in the southern states of Australia, certainly qualifies as being of interest to students, and several authors (Clarke (1984,1988),Weal (1987),Schwertman & Howard (1989),Watson (1991)), have suggested ways to incorporate football into the classroom. In this article, we show that a mathematical analysis capable of being performed by secondary students can shed light on the appropriateness of the current AFL finals system a topic causing much discussion on radio and TV and in the daily press. To generate the 128 equally likelyresults the aid of a spreadsheet (or a word processor) is enlisted.


Acclimation of respiration to the light environments is important for a plant's carbon balance. Respiratory rates of mature leaves of Alocasia odora, a typical shade-tolerant species, were measured during the night for 14 d after reciprocal transfers between high- (330 μmol m -2 s -1 ) and low-light (20 μmol m -2 s -1 ) environments. Following the transfer, both the rate of CO 2 efflux and that of O 2 uptake of A. odora leaves adjusted to the new light environments. The O 2 -uptake rates changed more slowly than the CO 2 -efflux rates under the new environments. Leaf mass per area also changed after the transfer. We analysed whether substrate availability or ATP-consumption rates influence the respiratory acclimation. Since the addition of sucrose to leaf segments did not influence the O 2 -uptake rates, the change of respiratory substrate availability was not responsible for the respiratory acclimation. The addition of an uncoupler induced increases in the O 2 -uptake rates, and the degree of enhancement significantly decreased after the transfer from low to high irradiance. Thus, the change in ATP-consumption rates was responsible for the changes in respiratory rates in the plants transferred from low to high light. Potential rates of O 2 uptake, as measured in the presence of both the substrate and the uncoupler, changed after the transfer, and strongly correlated with the O 2 -uptake rates, irrespective of the directions of transfer (r = 0.961). There was a strong correlation between maximal activities of NAD-isocitrate dehydrogenase and the potential rates of O 2 uptake (r = 0.933), but a weaker correlation between those of cytochrome c oxidase and the potential rates (r = 0.689). These data indicate that the changes of light environments altered the respiratory rates via the change of the respiratory ATP demand, and that the altered rates of respiration will induce the changes of the respiratory capacities.


A variation of Newton's constant $G$ over cosmological time scales would modify the main-squence time of globular cluster (GC) stars. We have calculated the evolution of low-mass stars typical for GCs both for standard non-varying $G$ and under the assumption of a linear variation of $G$. The age of the isochrones resulting from the latter models then was chosen such that the isochrones mimicked the standard ones at the turnoff. Assuming that the true age of GCs is between $8$ and $20\,\rm Gyr$, and because their apparent age is between $14$ and $18\,\rm Gyr$, we find that today $-35{\times}10^{-12}\,{\rm yr}^{-1}\la\dot{G}/G\la 7{\times}10^{-12}\,{\rm yr}^{-1}$. The upper limit (gravity weaker in the past) is competitive with direct present-day bounds from celestial mechanics. Within independently determined $\dot{G}/G$ limits a time-varying $G$ as an explanation for the discrepancy between the cosmic expansion age and the apparent GC ages is conceivable.


c Indira Gandhi Centre for Abstract The present work focuses on testing of 316 L (N) variation in the stress intensity factor, Kt. The speci MPa. The stress distributions from the notch root to calculations simulated later with ANSYS software. attempted to evaluate stress offloading due to multiax © 2013 Published by Elsevier Ltd. Selection and/o Atomic Research


INTRODUCTION In the wake of the 9/11 attacks, and the subsequent presidentially declared war on terror,1 the President and the Executive Branch assumed new powers to respond to the perceived terrorist threat. Some of these powers, like those granted by the Patriot Act2 and the Authorization for the Use of Military Force,3 were granted by Congress. Other authority, such as the power to authorize the National Security Agency ("NSA") to conduct warrantless wiretaps on American citizens4 and the power to use coercive interrogation techniques,5 was assumed by the President without any congressional authorization. The President took these actions in accordance with secret legal opinions issued by the Department of Justice's Office of Legal Counsel ("OLC").6 The OLC memoranda supported a conception of the President's commander-in-chief powers that was so broad as to be virtually unlimited, and they rejected the notion that Congress could statutorily control the President's exercise of this authority.7 Not surprisingly, the OLC memoranda prompted a storm of protest.8 One commentator wrote that the OLCs torture memorandum was not something "of which anyone could be proud" and that "[t]he overwhelming response by experts in criminal, international, constitutional, and military law was that the legal analysis in the government memos was so faulty that the lawyers' advice was incompetent."9 This critique of the OLC memoranda prompted observers to question the process by which the memoranda were created, a process that excluded anyone who might have differing views and that was designed to create a brief for presidential authority rather than a deliberate and independent assessment of the powers of the President.10 Scholars have begun to question whether the Department of Justice, the Office of the Solicitor General ("SG"), and the OLC, in particular, were capable of providing anything other than position papers on behalf of unrestricted presidential power.11 As a result, these criticisms have caused some to wonder whether the Department of Justice can adequately protect the constitutional separation of powers in its current form. Although many would agree with former OLC chief, Theodore Olson, that "it is not our function to prepare an advocate's brief or simply to find support for what we or our clients might like the law to be,"12 other commentators have begun to suggest that the Department of Justice needs to develop new internal checks on the issuance of legal opinions13 or have even questioned whether the Constitution should be amended to make the Attorney General independent from the President's control.14 These proposals are not new. Congress held hearings on the possibility of an independent Department of Justice after the Watergate scandal.15 The issue was also raised by President Carter, who requested the Department of Justice to analyze whether Congress could constitutionaUy make the Department of Justice independent from the President's control.16 The tendency of all these discussions is to focus upon visible assertions of presidential authority. The exercise of presidential authority in the area of national security or war power certainly grabs our attention and demonstrates the importance of independent and unbiased legal advice that properly constrains the exercise of presidential authority. But these dramatic examples of presidential power are not the only context in which the Department of Justice exercises considerable audiority over the constitutional separation of powers. There are innumerable ways in which the Department's control over the litigation on behalf of the United States gives it the opportunity to respect or to evade the audiority aUocated so carefully by the Constitution. In particular, the Department's actions can respect or subvert the Constitution's grant of appropriations authority to Congress. The Constitution clearly and unambiguously places control over the appropriation of federal funds squarely in the hands of Congress. …


The substitution of a siloxy group using thiosilanes smoothly occurred in the presence of InI3 catalyst to yield the corresponding thioethers. InI3 was a specifically effective catalyst in this reaction system, while other typical Lewis acids such as BF3·OEt2, AlCl3, and TiCl4 were ineffective. Various silyl ethers such as primary alkyl, secondary alkyl, tertiary alkyl, allylic, benzylic, and propargylic types were applicable. In addition, bulky OSitBuMe2 and OSiiPr3 groups, other than the OSiMe3 group, were successfully substituted. The substitution reaction of enantiopure secondary benzylic silyl ether yielded the corresponding racemic thioether product, which suggested that the reaction of tertiary alkyl, secondary alkyl, benzylic, and propargylic silyl ethers would proceed via a SN1 mechanism.


This thesis makes partly catalogization of historical building plans from the second half of the 19th century, which were preserved at the building archives of the village Přikazy by Olomouc. Catalogue si divided into two sections - one part is the common houses and second part is the frames buildings. Based on this analysis, thesis contributes to knowledge of developing of traditional country house and farmers building of the region Hana in this given period.


The oldest meaning of the word "xing" was punishment of spoiling body,and later which standing for all punishment.The oldest meaning of the word "fa" was to send into exile after judging by deity."yu" and "lv" was the same word."yu" means the limitation and criterion,and so "lv" denotes law.


The present study was conducted in Saurashtra region of Gujarat. Out of eleven districts, six districts were selected randomly and 120 extension personnel were selected proportionately from each districts. Fifteen independent variables were taken in this study and the dependent variable chosen was the extent of ICT utilization. It was found that there was a positive and highly significant association between educational status, innovation proneness, attitude, knowledge about ICT and extent of ICT utilization. Age had highly significant and negative association with extent of ICT utilization. Social participation, mass media liveliness, training undergone, infrastructure facilities had a significant and positive correlation with extent of ICT utilization. The relationship between gender, work experience, native place, achievement motivation, job commitment, professional zeal and extent of ICT utilization was non-significant.


This paper adopts steam distillation and direct extraction collaborate to extract aroma components of the Kumaiti apricot in the Luntai county of Xinjiang,and GC-MS analysis is used to study on the aroma component of the Kumaiti apricot.The result show that there are 20 kinds of chemistry constituents is identified,main-constituent is 2-hexen-1-ol,linalool,mycenol,2-propenal-3-pheny,5-hexyl-3-furan-ketone、2-diethylsilanediol.These constituents are consisited of special aroma in the Luntai county of XinJiang.According the aroma component of the kumaiti apricot to design orthogonal,the optimal extraction craft is determined as follows:the distillation temperature at 60 ℃,the distillation time at 2.0 h,the condensation water temperature at 25 ℃,the dense temperature of aroma component at 35 ℃,the content of aroma component was 23.06%.


The Seventeenth Congress of Communist Party of China clearly puts forward that we should build ecological civilization and adds this into the general target of constructing a society of well-off life.Furthermore,this respects the historical rules and fully carries out the scientific concept of development.To construct ecological civilization means to form an industrial structure,economical growing model and consumption pattern which can save energy and protect the ecological environment.Yunnan is known as the kingdom of various of plants,animals and the non-ferrous metal.It is also a province with complex landform,where many ethnic groups live.And just for these special natural and cultural conditions,Yunnan has the perfect qualifications to establish ecological civilized villages with ethnic culture.


Objective  Vascular dysfunction and accelerated atherosclerosis are prominent features of hypothyroidism. The relative roles of thyroid hormone (TH) deficiency and the associated vascular risk conditions are still unclear. We studied the impact of acute and chronic hypothyroidism on vascular reactivity.


An examination of 80 patients with ischaemic cerebrovascular disease, subdivided into 5 groups according to platelet antiaggregant treatment, demonstrated the effectiveness of resinated Isoxysuprine in preventing recurrences. The drug's success can most probably be attributed to its particular action mechanism.


3. Update on assessment plans for oral communication, ethical reflection, diversity: as reported by Bernadette Morris, the curriculum committee will announce anything we need and there is an understanding we can't hold off on anything to be assessed. We then discussed how ethical reflection, diversity and oral communication will be assessed in Spring 2010 and the first two possibly again in Fall 2010. We want to first survey what faculty are doing in these courses now, and Richard Kelder will form survey questions.


Our aim is to think about the dialogue between a Japanese and a inquirer, entitled Aus einemGespräch von der Sprache. Zwischen einem Japaner und einem Fragendem (1953-54). We try to arguethat, although there is no philosophy of language in Martin Heidegger there is a powerful languagedesign that marks the relationship with the being. Language becomes a saying that is anappropriation of what is given, that is, of what appears and becomes present. It is this relationshipwith the appearing that shows the power and mystery of language.


In the competitive age of the 21st century, the 'information' is becoming the source of energy. Today the extension information regarding various operations in agriculture and animal husbandry has been viewed as an important input for the production process. The present paper focuses on assessment of information needs of dairy owners in Indian state Maharashtra. Through a pilot study 40 dairy owners were interviewed for their information need on various animal husbandry practices, which revealed 'Animal health management' as important aspect on which they need information. Further to know the specific information needs on 'Animal health management' 120 dairy owners were interviewed. The study showed that, animal diseases and disorders like Mastitis, Babesiosis, Milk fever, Foot & mouth disease, Hemorrhagic Septicemia, Anthrax, Ketosis, Theileriosis, Anoestrous, Repeat Breeding, etc. are of prime concern for these dairy owners.


The article reveals the specifics of innovation as a socio-economic phenomenon. Comments on the process of innovation are given both from a perspective of contradictions resolution that arise in the market of goods and services, as well as from a perspective of the participants in this process. Revealed the relationship between basic elements: novelty - novation - innovation.


RANDI HERMAWAN BULO. The Influence Corporate Governance Mechanism and Age of Company Toward Timeliness of Annual Report. Fakultas Ekonomi Universitas Negeri Jakarta. 2014.
The objective of study examines the influence of mechanism corporate governance consist of managerial ownership and institusional ownership, and then age of company on timeliness of corporate financial reporting. This research represents the empirical test which used purposive sampling techniques in data collection. Data were collected using a secondary data of 28 from mining company listed in Indonesian Stock Exchange 2010-2012. Data analysis uses multiple regression with the program SPSS 16.00 version for windows.
Results of hypothesis examination indicate there is influence between institutional ownership and age of company on Timeliness of Corporate Financial Reporting, and there is no influence between Managerial ownership on Timeliness of Corporate Financial Reporting.


Soil-erosion-induced land degradation and crop production loss is a great challenge in the Ethiopian highlands. Consequently, the government has invested in soil and water conservation (SWC) measures where farmland terracing is among the widely implemented practices. The purpose of this study was to analyse the performance of terracing with respect to crop productivity. Yield differences across the slope of the terrain, within a terrace and across terrace age were evaluated. The study was conducted in the Maybar soil conservation research site (MSCRS) in Wello, northern Ethiopia. It is located between 10◦58' and 11◦02' N latitude and 39◦38' and 39◦40' E longitude. Yield data (grain and biomass) of seven crops such as wheat (Triticum spp), emmer wheat (Triticum spp), horse bean (Vicia faba), field pea (Pisum sativum), barley (Hordeum spp), maize (Zea mays) and teff (Eragrostis tef ) collected between 1995 and 2009 from 40 fixed plots on three terrace positions (upper, middle and lower) were statistically analysed using a mixed linear model that employed Tukey-Kramer adjustment in SAS (Version 9.2). Generally, yields of all crops except wheat decreased significantly (on average 0.37 to 0.15 t ha−1) from the upper terrace position towards the lower position. Unlike in other studies, the differences could be due to the soil depth gradient that in turn influenced nutrient and soil-water storage. On the other hand, yields showed insignificant differences across the terrain, they showed a decreasing tendency with slope increase. This indicates that terracing reduced soil erosion and nutrient translocation. With terrace age, yields showed only slight changes. The stable yield under limited fertility improvement measures and reduced fallowing indicates that terracing reduced soil and nutrient loss through erosion. However, terracing alone does not improve soil fertility and thereby crop production. Thus, in order to significantly increase yields terracing should be supplemented by soil fertility amendments.


Food supply chain is one of the most complex supply chain networks due to its perishable nature and customer oriented products, and food safety is the major concern for this industry. IT system could help to minimize the production and consumption of unsafe food by controlling and monitoring the entire system. However, there have been many issues in adoption of IT system in this industry specifically within SMEs sector. With this regard, this study presents a novel approach to use IT and tractability systems in the food supply chain, using application of RFID and central database. Keywords—Food Supply Chain, IT System, Food Safety, SME.


Three studies were conducted to investigate if four and five year old children recognize that kinship relationships are determined by biological associations and not environmental conditions. All three studies employed the "switched-at-birth" task. Study 1 investigated if children and adults recognize who the biological parents and siblings are. Study 2 examined preschoolers' and adults' recognition of who the biological parents and siblings are when step parents and step siblings were introduced into the family. Study 3 examined if children and adults extend their knowledge of kinship relationships to non-human creatures. For Studies 1 and 2, results indicated that preschoolers and adults have a robust and accurate biological model of kinship for both biological parents and sibling relationships. However in Study 3, preschoolers had a more difficult time recognizing biological sibling relationships than biological parent relationships in the presence of step parents and step siblings for non-human biological creatures. In totality, these results suggest that even young children (like adults) have a robust theory of kinship when reasoning about human relationships. However children's model of kinship is fragile and still developing when reasoning and extending their knowledge about humans to non-human species.


Objective To observe the changes of lung parameters,the ratios of B and T lymphocyte attenuator(BTLA) and serum cytokines in patients with knee osteoarthritis (KOA),and explore possible molecular mechanism of them.Methods Forty-seven cases of knee osteoarthritis from the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from 2011 October to 2012 July were analyzed in this study.Pulmonary parameters were detected by spirometer; B and T lymphocyte attenuator(BTLA) was detected by flow cytometry ; Interleukin (IL)-1β,IL-10,matrix metalloproteinase-9 (MMP-9),tissue inhibitor of matrix metalloprotease-1 (TIMP-1) were detected by ELISA;ESR was determined by Westergren method ; hs-CRP was determined by the automatic biochemistry analyzer.Results (1) Compared with NC group,levels of FVC,FEV1,FEV1/FVC,PEF,MEF25.75,MEF50,MEF25,CD3 + BTLA+ T cell,CD4+ BTLA+ Tcell,IL-10,TIMP1 were significantly decreased,IL-1 β,MMP9 were significantly increased.(2)Correlation analysis showed FVC was negatively correlated to Lequesne MG,symptom classify quantization scores,course,MMP9,while positively related to CD3+ BTLA+T cell,IL-10,TIMP1 ;FEV1 was positively correlated to CD3 + BTLA+T cell,CD4+ BTLA+T cell,TIMP1,while negatively correlated to course ; MEF50 was positively related to CD3+BTLA+T cell,CD4+ BTLA+T cell.Conclusion While articular cartilage lesions occurred in KOA patients,the lung function was also declined.The mechanism may be associated with the declination of expression of BTLA,which can cause up-regulating of IL-1 β,MMP9 and down-regulating of IL-10,TIMP1,thus leading to immune dysfunction and abnormal immune response.Those may induce airway injuries and result in lung function decline finally.

Key words:
Knee osteoarthritis; B and T lymphocyte attenuator; Matrix metalloproteinase; Lung function


The Covid-19 pandemic that occurred globally has an impact on various sectors in Indonesia including the MSMEs sector. Based on these conditions, a marketing strategy is needed for MSMEs in Indonesia to be sustainable. The research aims to analyze and describe marketing strategies for MSMEs to survive in the Covid-19 pandemic condition. This research uses exploratory qualitative analysis with participatory observation techniques. This research uses primary data from observations and secondary data from previous studies. The results recommend MSMEs to sell their products via e-commerce and promote via digital marketing as a marketing strategy. Moreover, MSMEs need to optimizing customer marketing relationships in order to create a loyal customer. Loyal customers have the potential to make repeat purchases and recommend products to other potential consumers. By implementing this strategy, it is hoped that the MSME business will continue to survive and have a positive impact on society and the economy.


Introduction: Siravedhana, is an important para surgical procedure to withdraw the vitiated blood from body but before performing it the knowledge of Avedhya Sira is mandatory as any injury to these can cause disability or even death. There is total 98 Avedhya Sira in the body. Out of which two are pertaining to the region of Hanu. Any injury to these can cause similar consequences. But the exact location and the structural entity pertaining to it is not clearly mentioned in the classic texts.
Material and Methods: Conceptual study carried out by reviewing classical texts, contemporary science, journals, published research works.
Conclusion: On the lateral aspect of the head near the anterior margin of the auricle in front of the tragus, the Maxillary artery and Pterygoid venous plexus can be considered as Hanugata Avedhya Sira based on their location and Viddha Lakshana.


The following unusual case seems of sufficient interest to deserve publication: Patient. —Mrs. W., Mexican, 30 years of age, came to me Aug. 1, 1904, complaining of a "sore nose." History. —About a year before she accidentally struck her nose violently against a door. There was no hemorrhage, nor even broken skin, but the blow was a severe one, and her nose had troubled her ever since, hurting severely one week, and appearing to get almost well another. Examination. —Inspection showed nothing abnormal except a little redness and swelling about the lower left ala. On palpating the nose lightly with my finger there was a most peculiar sensation of something slipping or giving way beneath. This also caused some pain. I diagnosed dislocation of the left lower lateral cartilage of the nose. Ordinarily there was no displacement because the elasticity of the surrounding tissues held it in place. Yet it


A probabilistic damage identification method based on one-dimensional convolutional neural network (1D-CNN) is proposed in this paper. Initially, a three-dimensional solid model of a cantilever beam with three surface bonded PZT transducers was built using ANSYS, and the damage was simulated by setting up cutouts on the beam to obtain the PZT admittance signals under different working conditions; the admittance signals were then input into the constructed 1D-CNN for training; finally, the test data were input into the trained network model to locate and quantify the damage and verify the effectiveness of the approach. The findings indicate that this technique is capable of identifying the challenging issue of damage localization and quantification in structural damage diagnosis.


Being at Genetic Risk: Toward a Rhetoric of Care. Kelly Pender. University Park, PA, The Pennsylvania State Press, 2018. 174 pages, $69.95 hardcover. Publisher webpage: https://www.psupress.org/books/titles/978-0-271-08212-7.html


Finite element methods have recently gained great interest for solving large-scale ocean circulation models, which are based on 2-3D coupled Navier-Stokes equations. The corresponding discretized system can be treated by using implicit or explicit iterative methods. In this work we are interested in the effective implementation of a recent semi-implicit method on CINECA Cray-T3D, for integrating in time the corresponding velocity-pressure equations. The original scalar code was initially implemented at the Institute of Marine and Coastal Sciences, Rutgers University (NJ). Of particular interest is the fact that the elemental structure of the discretized problem may yield effective load distribution among the nodes. A complete data layout analysis is proposed, and first experimental results are provided in order to investigate the efficiency of the code.


e13560 Background: 3-Phosphatidylinositide-dependent kinase 1 (PDK1) interacts with its substrate kinases after binding phosphatidylinositol (PI). PDK1 also affects downstream targets in a PI-independent manner, causing activation of additional pathways. PDK1 activation of AKT involves both PI-dependent and independent mechanisms, making PDK1 a challenging target for AKT pathway inhibition. Here we describe a novel PDK1 inhibitor, SNS-391, that is highly effective at inhibiting AKT activity with broad anti-tumor activity. Methods: SNS-391 was evaluated in the prostate cancer PC-3 cell line (PTEN null) for inhibition of several signaling pathways and was tested in proliferation assays in over 50 tumor cell lines of prostate, lung, colon, breast, melanoma, and pancreatic origin. Tumor xenograft studies were conducted in prostate, gastric, lung, pancreatic, and colorectal cancer models. Tumor samples were analyzed for pathway inhibition and compound exposure to develop PK/PD relationships. Results: SNS-391 (...


process of denazification continues, in usually unacknowledged ways, to shape the way we debate the issues. The case of Orff and Jenkins is a stunning example, as though we did not already know so, of how fallible and muddled these administrators were. Kater provides excellent guidance through his cases as they came before the tribunals of immediate postwar judgment. In our own era of heightened sensitivity to the once hidden political contexts of cultural products, what we need next is a comprehensive account of the legacy of denazification on postwar cultural history.


The enterprises of commodities circulation, which adopts selling price business accounting, use traditional methods to calculate the rate of price differences between purchasing and selling, the original commodities selling cost, thus not only is the account set up complexly, but also there is a large amount of work and calculation processes are very inconvenient, so it is easy to make mistakes. If the simplified calculation method, called calculation method of the rate of price differences with tax, is adopted it can simplify calculation processes, reduce the amount of work, simplify the setting up of account. So its of great benefit to improve efficiency.


The sharing of information of the preschool teachers is understood and it is significant for them to promote professional.Various factors lead to the difficulties in sharing information in China.Some measures must be taken to overcome the difficulties.