'HARBAR SOYBEAN [Glycine max (L.) Merr.] (Reg. no. CV300, PI 561702) was developed at the Northwest Agricultural Research Center (CIANO-INIFAP-SARH) Cd. Obregon, Sonora, Mexico. It was released as a high-yielding, stable cultivar adapted for production in northwest Mexico. Harbar was derived from the cross 'Cajeme' x 'Rad'. Cajeme is a selection from the cross N44-92 ('Ogden' x 'Haberlandt') x Lee. The percentage of Rad is unknown. Harbar originated as an F2 plant selection, was bulked in the F3 generation, and was designated II-S35-6-M. It was tested in the National Uniform Soybean Trial (North Zone) from 1985 through 1987. In these tests, Harbar averaged 6% higher in seed yield than Cajeme and was better adapted to the Yaqui and Mayo valleys of Sonora, Fuerte Valley of Sinaloa, and the soybean growing regions of Chihuahua (1). Harbar is a Maturity Group VI cultivar similar in morphology and agronomic characteristics to Cajeme. It has a determinate growth habit, begins flowering =47 d after planting, and reaches physiological maturity in =119 d. Mature plants average 90 cm in height. It has purple flowers, tawny pubescence, and yellow seed with black or gray hila. Seed weight averages 14.9. Seed protein content averages 391 g kgand oil content 233 g kg". The check variety Cajeme has an average protein content of 409 g kgand oil content of 226 g kg-. Harbar is resistant to both lodging and shattering. Seed of Harbar was distributed to seed-producing organizations in Sonora in 1989. Breeder seed will be maintained by CIANO in Cd. Obregon, Sonora, Mexico. Additional information on the performance and characteristics of Harbar has been published (2).


Activation of sphingomyelinase (SMase) as a result of a general inflammatory response has been implicated as a mechanism underlying disease‐related loss of skeletal muscle mass and function in several clinical conditions including heart failure. Here, for the first time, we characterize the effects of SMase activity on human muscle fibre contractile function and assess skeletal muscle SMase activity in heart failure patients.


Aims. We show how the observed hydrogen Balmer and Lyman emission lines constrain the modeling of quiescent solar prominences. Methods. We compare space observations of Lyman lines with ground-based observations of Balmer lines for quiescent solar prominences of comparable brightness defined by their Hβ emission. Results. The effective number densities of hydrogen atoms emitting from the same upper level u deduced from the corresponding emerging Lyman and Balmer line emissions show large differences that diminish with increasing level number and converge at the highest level numbers. Hydrogen atoms excited in u = 5 contribute 250 times less, and those in u = 8 still contribute 65 times less to the Lyman than to the corresponding Balmer emission, supporting the idea of distinct spatial origin of the emissions of both series. This is also indicated by the line widths. The high optical thickness of all Lyman members allows the brightness temperature Tb to be estimated from the spectral radiance at line center, where Tb is found to be largely independent of the upper level number, in contrast to the (known) behavior of the Balmer lines.


Founded upon the Internet of Things (IoT), the technological landscape of Smart Cities brings a wide range of operational parameters which pose significant challenges for architectural concerns. Herein we provide a unified view on the data path issues of sensing applications in terms of generic capabilities. We touch information granularity and semantic load concerns, discussing the escalation of detail from raw data to event indicators and, ultimately, deductions. Furthermore, we discuss customization and non-functional optimizations associated to particular application domains. In this regard, we identify key components in the data path. We conclude with design insights for an accommodating and efficient design of the data path for IoT applications.


may be concerned about such statements as &dquo;split-half and KuderRichardson coefficients are ... measures of the stability of the test ...&dquo; or that intelligence tests may be used &dquo;to identify individuals who have latent mental capacity,&dquo; or that Thorndike's three aspects of intelligence are &dquo;level, extent, and spread.&dquo; It seems to the reviewer that the use of the term capacity and the subsequent discussion in the text of under-achievement and overachievement tends to perpetuate anachronisms in measurement. Indeed the authors state that &dquo;an overachiever ... is achieving at a level beyond his measured capacity.&dquo; In general, the text might have been greatly improved by covering fewer topics but in more detail. However, if the text is used by teachers who already have some background in measurement, it may well prove to be of value as a general review. GILBERT SAX


New generation sequencing techniques allow us to characterize the bacterial populations present in any organ or area. The knowledge of the uterine microbiota in bovines has grown in recent years as it has been shown that it influences fertility, however, there are very few studies in beef cattle. This work aims to contribute by generating information in beef cows, characterizing the uterine microbiome, determined by the sequencing of the hypervariate regions of gen 16S rRNA in samples obtained by the cytobrush technique in open cows prior to and during a standard synchronization, using an intravaginal device of progesterone, plus benzoate of estradiol and prostaglandins. The relative abundance in group I and II were very similar; Firmicutes, Proteobacteria, Bacteroidetes and Actinobacteria. Group III was Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, and Fusobacteria, and Group IV, Proteobacteria, Firmicutes, Actinobacteria and Fusobacteria. The taxonomic composition in utero decreases throughout the synchronization protocol. There are internal and external factors that alter bacterial populations such as health status, hormones, pregnancy, medication administration, among others. To establish whether bacterial abundance has an influence on fertility, more robust studies are needed.


Acupuncture can not only generally promote the compensatory repair of the nerve cells,but also act on various neural pathways to perform regulation.Acupuncture can inhibit or promote the expression of many proteins,and thus influence various signal pathways.Acupuncture sometimes can impact he targets of rapamycin which connect various signal pathways to inhibit negative signal pathway and enhance positive signal pathways on the whole.However,the primary and secondary roles of the regulation performed on the signal pathways by current acupuncture are notdefinite,so are the regulation roles of signal pathways.Therefore,further study should be conducted to seek for more exact action mechanism and targets to make clear the primary and secondary roles.


Glyphochaitophorus Qiao gen. nov. with one new species Glyphochaitophorus cristaphis Qiao sp. nov. on Acer palmatum from Tibet, China is described and illustrated in the aphid tribe Chaitophorini. A key to Glyphochaitophorus and allied genera is provided.


Mathematics is a uniquely powerful toolbox of humanity. Unlike other things, mathematics is logically selfconsistent and things are either right or wrong.


Objectives: This article examines the impact of the global savings glut on the long-term interest rates in the United States before the Great Financial Crisis. It presents the impact mechanics of global savings on interest rates, discusses arguments supporting and contradicting the significance of this phenomenon, presents an alternative concept, namely global liquidity glut, and estimates the significance of both phenomena in shaping long-term interest rates in the USA before the crisis.
Research Design & Methods: First, the impact of purchases of the US treasury bonds made by foreign investors on long-term interest rates is being assessed. Second, metrics representing global savings and liquidity gluts are being used to explain those purchases. Finally, a counterfactual exercise is used to reveal the impact that each of those factors had on the American ten-year treasury yields.
Findings: The statistical analysis of both effects shows that foreign purchases of the Treasuries lowered the US longterm interest rates by up to 140 bps, with excess global savings depressing them by approximately 45 bps, and excess liquidity by another 75 bps.
Implications / Recommendations: Monetary policy, as well as savings rates, might have wider than only local consequences. Excess liquidity and savings in one country can impact interest rates in other areas.
Contribution / Value Added: This article presents an alternative and neglected in literature explanation for the phenomena of low long-term interest rates before the Great Financial Crisis in the USA, namely global liquidity glut that depressed interest rates more powerfully than excessive global savings, contributing to the development of the investment bubble on the housing market and, thus, the Great Financial Crisis.


ABSTRACT This paper discusses methodological problems of accurate area determination in the cadaster. The paper contrasts the ambiguous legal definition of the parcel boundary and parcel area in relation to the theoretically well-defined geodetic parcel boundary and the geodetic parcel area on the reference ellipsoid. To align with the real world, parcel area must account for terrain elevation. Various approximate methods for area determination which can be used in the cadaster are tested. A highly accurate method for parcel area computation is proposed, based on an equal-area projection. Considering the geodetic parcel area as a reference, the achievable accuracy of different methods is evaluated. For this analysis, the coordinates of the parcel boundary points are treated as error-free. Finally, the relevance of various systematic errors is discussed in relation to the statistical uncertainty of the parcel area, which could be gained by an a real-time kinematic GNSS survey. A case study is presented for the territory of Slovenia, its georeferencing rules, land demarcation pattern, and characteristics of its topography. Based on the results of this study, some general recommendations for the parcel area determination are given.


The utility model provides a subway roof assembly flexible tool. The subway roof assembly flexible tool comprises longitudinal beams and stand columns, wherein the two longitudinal beams which are symmetrical and identical in length are fixed to the stand columns; detachable positioning blocks are evenly arranged on the upper surfaces of the longitudinal beams; devices capable of tightly pressing the longitudinal beams are evenly arranged on the outer side faces of the longitudinal beams; end portion positioning devices are arranged on the tips of the longitudinal beams. The whole subway roof assembly flexible tool is simple and reasonable in structure, safe, stable, reliable, and capable of being reasonably matched with a workpiece.


The present invention provides compounds of Formula (I) or pharmaceutical acceptable salts thereof wherein A, G and R 1 are as defined in the claims which are antibacterial agents.


The temperature rise of the high power density motor directly influences the stability and reliability of the operation of the motor, and it has great significance to accurately calculate the temperature rise of the motor and rationally design the cooling system. In this paper, a water-cooled permanent magnet synchronous motor with a rated power of 40 kW is considered. Two types of waterway structures used as the cooling system are respectively analyzed, and the reasonable waterway structure is selected from the aspects of pressure, flow velocity, cooling effect and so on. The loss values obtained from electromagnetic field calculation are applied to the temperature field as the heat source. The 3-D temperature field simulation model of the motor is established based on the reasonable equivalence and assumption, and the temperature field simulation of the rated working condition and the short-time peak working condition is carried out based on the finite element method and fluid-solid coupling. The temperature field simulation result is agreed well with the temperature rise experiment result, which verifies the accuracy of the simulation and the effectiveness of the cooling system, and ensures the stable and reliable operation of the motor.


In Time of national fitness,outdoor sports clubs are the main carrier of mass outdoor sports activities in our country.There are many problems with outdoor sports clubs through survey,for examples:(1)management is not standard;(2)organization structure is not integrity;(3)personnel quality is not high;(4)market position is not accurate;(5)service products are identical;(6)the financing channel is quite simplex;(7)risk awareness is weak. In order to facilitate the scientific,formal,healthy development of outdoor sports clubs,we can take the following measures.(1)perfect management mechanism and system,strengthen the club's construction;(2)improve the ability and management level to adapt to the environment;(3)develop the characteristics of service products actively;(4)make innovations for marketing method.(5)strengthen of working team,improve the ability of employees;(6)raise consumers' awareness of self protection,guide rational consumption,etc.


The geographical distribution of six species of white fly associated to Citrus spp. in Brazil is presented. Geographica1 distribution, hosts and natural enemies were based on material from 13 Brazilian States, field monitoring and visits to the more States and also review of the literature. Identification key was based on genera1 characters, morphologycal and macroscopycal of the "puparium".


Food contamination with fungi and their toxins is a serious public health issue. Peanuts can be exposed to microbial spoilage and adverse changes in their taste sensory properties. Chitosan is one of the biopolymers that is biodegradable and has antimicrobial activity. The purpose of this study was to investigate the effect of peanut coating on chitosan and chitosan nanoparticles on Aspergillus flavus and the taste sensory properties of peanut. Mold counting tests were performed by culture on Saburo dextrose agar medium, culture progress percentage by slide culture and microscopic observation and sensory properties (taste, color and general acceptance) by 5-point hedonic method by 15 evaluators. For this purpose, the experiments were performed on peanuts by covering the levels of 0.5, 1 and 1.5% of chitosan and chitosan nanoparticles and the control sample (7 treatments in total) at room temperature and darkness on days 0, 14, 28 and 42. The effect of type of treatments and storage time on the total count and the rate of progression of Aspergillus flavus and sensory characteristics was significant (P<0.01). But the interaction between treatments and the storage time of the samples were not significantly different. The highest and lowest antimicrobial effects were related to concentrations of 0.5% chitosan and 1.5% chitosan nanoparticles. But the highest sensory score was observed in the control and day zero samples and the lowest score was observed in the samples coated with 1.5% chitosan nanoparticles. The most suitable coating concentration can be 0.5% chitosan and 1% chitosan nanoparticles. Received: 2021.02.05 Revised: 2021.08.09 Accepted: 2021.08.21 Online publishing: 2022.01.05


Music education is an eclectic field of study, and those concerned with questions of musical learning and teaching draw upon a variety of disciplines including psychology, sociology, history, philosophy, ethnomusicology, and music therapy. For this Special Issue, we have asked leading scholars within these disciplines to share insights on how their research area might contribute to a greater understanding of the learning and teaching of music. Our aim and theirs is to communicate recent developments in the disciplines to music educators, and hopefully to stimulate in the pages of BJME a dialogue with colleagues in related fields of interest.


Energy transfer at 1500 nm in lead fluoroborate glasses (PbO–PbF2–B2O3) codoped with Er3+ and Yb3+ is studied for the first time to the authors' knowledge. A sample codoped with 1 mol. % of Yb2O3 and 0.01 mol. % of Er2O3 has a measured fluorescence lifetime of (1.30±0.07) ms and an energy transfer efficiency of 80%. Also, a large emission band, of 72.4 nm has a measured peak emission cross section of (0.73±0.06)×10-20cm2. The calculated Judd–Ofelt parameters are Ω2=(3.51±0.14)×10-20 cm2,Ω4=(1.09±0.07)×10-20 cm2, and Ω6=(0.94±0.07)×10-20 cm2. The temporal evolution of the Yb3+ fluorescence is fitted by use of the Yokota–Tanimoto expression to yield the Yb3+ diffusion constant [(1.6±0.2)×10-10 cm2 s-1] and the critical radius of Yb3+/Er3+(18±1)×10-8 cm. Results with the singly doped samples produced are presented to clarify the energy transfer process.


The pv_atmos package allows for an automated approach to 4D (3D space + time) visualization of atmospheric data in netCDF format. Using Python scripting, the open source software ParaView is used to load, process, and visualize data. The scripts automatize the loading of data on a longitude-latitude-pressure grid, and re-compute the grid for a log-pressure or spherical representation of all data. Grid lines, planes, and labels can be added if desired. Two example scripts are included in the repository.


This paper presents the results of an analysis carried out to investigate the thermal response of ITER divertor plasma facing components (PFCs) clad with Be, W, and CFC, to high-recycling, high-power thermal transients (i.e. 10-30 MW/m/sup 2/) which are anticipated to last up to a few seconds. The armour erosion and surface melting are estimated for the different plasma facing materials (PFMs) together with the maximum heat flux to the coolant, and armour/heat-sink interface temperature. The analysis assumes that intense target evaporation will lead to high radiative power losses in the plasma in front of the target which 'self-protects' the target. The cases analysed clarify the influence of several key parameters such as the plasma heat flux to the target, the loss of the melt layer, the duration of the event, the thickness of the armour, and comparison is made with cases without vapour shielding. Finally, some implications for the performance and lifetime of divertor PFCs clad with different PFMs are discussed.


Indonesia women's empowerment level positions when compared to other Southeast Asian countries are at the lowest position as measured by the Gender Inequality Index (GII). Basically, socio-economic factors can cause women's empowerment in Indonesia in low level. There is a difference of view in reviewing the growing empowerment of women within the paradigm of conventional and Islamic. In the conventional paradigm, women empowerment often linked gender issues or feminism that demands freedom without limits and oriented to mastery of the material. While in Islamic paradigm, male and female Muslims have the duty and the same opportunity to obtain mercy from God. However, the empowerment of women in Islam should not be denied its main nature as a female. This research aims to construct an index of women's empowerment in accordance with Islamic principles. This study uses modification of the Women Empowerment Index (WEI) and Cumulative Women Empowermet Index (CEMP) as underlying index. In this study, Islamic Women Empowerment Index (IWEI) using four indicators, i.e. Family Decision Making Index (FDMI), Economic Decision Index (EDI), Physical Movement Decision Index (PMDI) and Political Autonomy Index (PAI). The population in this research is the housewife who is being mustahik zakat in Misykat DPU DT. Technique sample with purpossive sampling, the samples are obtained by the number of respondents as many as 100 people. The result shows that is the size of empowerment in the family (FDMI) and Economics (EDI) have a high score. While the two other indicators, i.e. physical mobility and political participation have a score by medium catgory. The implication of this research is that it is needed an index women empowerment which pays attention to the principles of the religion and attempts to improve the empowerment of women in social and economics based on Islamic principles.


Breeding program for yellow rust (Puccinia striiformis f.sp.tritici) resistance was initiated at Wheat Research Institute, Faisalabad, Pakistan, during 1992-93 for the development of wheat varieties having minor gene based resistance against yellow rust. Wheat germplasm was screened for yellow rust resistance under natural and high stress inoculation conditions with diversified inoculum at several locations. The rust development pattern was observed and data was recorded for yellow rust for two years. Accessions carrying minor genes were identified based on slow rusting behavior and low terminal rust reaction. Auqab 2000, Kohistan 97, Pb 96, Shalimar 88, HD 2179, Luan and Weaver showed moderate level of resistance against yellow rust at natural hot spot areas and under artificial inoculation conditions. The local adapted varieties like Lu 26, Pak 81, MH 97, Inqilab 91, Chenab 2000 and V-87094 (Wattan) have high yield potential history. These lines were crossed by following single cross, double cross, top cross or backcross method for pyramiding minor genes for rust resistance and high yield potential. Segregating material was evaluated under artificial rust inoculation and natural conditions using selected bulk method approach. The homozygous lines having high yield potential and better resistance than the parents and the existing wheat varieties were selected in F7 generation for the evaluation in station yield trials (A and B trials) for two years. In different ecological zones of Pakistan, these lines were also tested for yield and rust under Provincial (MICRO) & National (NUWYT) trials for one and two years respectively. The most promising crosses were Lu26/HD2179/2* Inqilab-91 (V-00183R), Shalimar-88/Weaver (V-02156), Shalimar88/Wattan//MH-97 (V-02192), Luan/Kohistan (V-03138), Shalimar-88/V-90A204//MH-97 (V-04178), Pb96/Wattan//MH-97 (V-04179), Chenab-2000/Inqilab-91 (V-05082),Lu-26/HD-2179//Chill'S' (V-06018), Shalimar-88/Pak-81//MH-97(V-06068), Auqab-2000 /Milan (V-6096), Oasis/5*Angra//Inqilab-91 (V-06117), and Lu26/HD2179(V-87094). Two varieties, Shafaq-06 and Lasani-08 have been released for general cultivation during years 2006 and 2008, respectively. Some other lines having better resistance than the parents are in the pipeline. Shafaq-06 and Lasani-08 have high yield potential and durable type of resistance mechanism for yellow rusts.


Objectives
To study the relation of acute kidney injury (AKI) and long-term chronic kidney disease (CKD) in patients with acute decompensated heart failure (ADHF).

Methods
The in-hospital and post-hospital clinical data of patients with ADHF were analyzed postoperatively. The AKI was diagnosed according to the KGIGO criteria, the estimated glomerular filtration rate was calculated based on serum creatinine value and the CKD was defined as an eGFR<60 mL·(min·1.73 m2)-1.

Results
Totally 318 patients were included. At 36 months after discharge, the decreased eGFR of 9.2% [95% confidential interval (CI) 5.9~13.0] in the AKI group was higher than the decreased eGFR of 3.8% (95% CI 1.15~5.52) in the non-AKI group. In multivariate Cox hazard ratio models, the hazard ratio (HR) of development of CKD stage was 3.012 (95% CI 1.917~4.305) in the patients with CKD at baseline, 1.849 (95% CI 1.205~2.395) in those without CKD at baseline and 1.975 (95% CI 1.213~2.435) in all the 318 patients.

Conclusions
The in-hospital AKI is an independent risk factor for long-term CKD development or progression, implicating the importance of long-term renal function in the patients with cardio-renal syndrome type 1.

Key words:
Kidney Diseases; Heart Failure; Syndrome; Prognosis


POEMS syndrome is a rare paraneoplastic disorder due to an underlying clone of aberrant plasma cells. The name POEMS is an acronym for some of the major disease manifestations, namely polyneuropathy, organomegaly, endocrinopathy, presence of monoclonal component, and skin changes. The clinical presentation can be various and could lead to delayed diagnosis and treatment. Little is known about the pathogenic mechanism, although the neoangiogenesis due to overproduction of vascular endothelial growth factor (VEGF) by plasma cells seems to play a key role. The latest evidence suggests that the blood concentration of this cytokine correlates with the activity of the syndrome: VEGF could then be used as a therapeutic target and a marker to monitor response. Several case reports have shown the efficacy of this approach, but extended studies are required to better define the use of antiVEGF in patients affected by POEMS syndrome.


The conventional energy sources depleted day by date. Alternate energy requirement is necessitate for our daily life. Our energy demand is met by standalone PV based system. This paper explained the simulation of a standalone photovoltaic power system erected in Mailam with different simulation tools. Solar resources for the design of this system were taken from the National Aeronautics and Space Administration (NASA) Surface Meteorology at a location of 22° 59' S, 14° 29' E with annual average solar radiation of 5.14 kWh/m2 /d. PV planner and PV syst simulation tools were used to analyze the design of photovoltaic power system model. The entire model was designed based on an hour-by-hour data depend on energy availability and its demands. A detailed design of standalone PV system with two different simulation tools were presented in this paper.


such a delusion was a sort of nightmare. In an equally rational manner he shows how untrustworthy were confessions extorted by the rack. With regard to the supposed injuries caused by the machinations of witches, Weyer has little difficulty in referring the alleged killing of cattle, destruction of crops, and raising of storms to natural causes. On the subject of bewitched persons, the imagined victims of the witches, his point of view is curious. Some of them were really cases of secret poisoning, where death was caused by material, not by spiritual, agencies. Others could be cured by medical and moral treatment. But many were cases of persons really possessed by evil spirits, though not thro'dgh the instrumentality of witches, who were quite powerless in these matters; for Weyer evidently had no doubt of the reality of demoniacal possession. It was reserved, we may say, for an English physician (Edward Jordan) in the reign of James I. to declare boldly that girls supposed to be possessed by evil spirits were merely suffering from " fits of the mother," that is, hysteria. We need not follow our author into his rational and naturalistic explanations of other supposed facts of witcheraft. IHis views may seem at the present day natural enough and even obvious, but it is difficult to exaggerate the originality of such opinions in his time, or the courage needed to avow them. His manly protest had a great, though not an immediate, success. His book went through six editions in Latin, two in German, and one in French, and a smaller book on the same subject was also several times reprinted. That it should provoke bitter opposition from the superstitious and often interested leaders of the witchcraft crusade was natural enough. In the long list of his opponents is found the name of James I of England, whose book, Doemonologia, refers expressly to Weyer. Weyer truly appears among his contemporaries, as Professor Binz says, like a sane man addressing the inmates of an enormous madhouse. He did not, however, want supporters and followers. The rare and curions volume of the EDglishman, Reginald Scot, The Discovcrie of WYitchcraft, published in ]584, was a courageous protest in the same direction, though whether Scot was acquainted with Weyer's writings we cannot say. But the peculiar interest of Weyer's way of treating the question is his clear appreciation of the physiological and medical side of the case, which is certainly more rational than the too hard and mechanical explanation which has been generally accepted: that malice and ignorance attributed to ignorant and innocent persons pretensions and crimes of wbich they themselves never dreamed. A physiological substratum there undoubtedly was, though it did not account for everything. Weyer's good sense and acumen are shown also in another book, De Jejuniis Commentitiis, where he gives some wonderful histories of " fasting girls," and relates by what judicious treatment he detected and cured one who came under his notice. For these and other interesting matters we must refer to Professor Binz's memoir, which is no less distinguished by its critical judgment than by its learning and literary accuracy.


The usual Green relations,*-Green relations are generalized to #-Green relations and the semilattice decomposition of■#-abundant semigroups is given.By using this decomposition,the authors show that an■#-abundant semigroup is a normal■#-abundant semigroup if and only if it is strong sem- ilattice of completely■#-simple semigroups.


Abstract:  In the present study we provide direct evidence for the involvement of rat microsomal cytochrome P450s in melatonin O‐demethylation and hydroxylation at two different positions: 2 and 6, as well as generation of N1‐acetyl‐N2‐formyl‐5‐methoxy‐kynuramine (AFMK) and two unknown products. Moreover, we found that mitochondrial cytochrome P450s also converts melatonin into AFMK, N‐acetylserotonin, 2‐hydroxymelatonin, 6‐hydroxymelatonin and the same two unknown products. Eadie–Hofstee plots for 6‐hydroxylation and O‐demethylation reactions were curvilinear for all tested fractions, suggestive of involvement of at least two components, one with a high affinity and low capacity, and another with a low affinity and high capacity. Mitochondrial cytochrome P450s exhibited higher affinity (suggesting lower Km value) and higher Vmax for melatonin 6‐hydroxylation and O‐demethylation for both high‐affinity and low‐affinity components as compared with microsomal enzymes. The intrinsic clearance for melatonin hydroxylation by high‐ and low‐affinity components displayed the highest values in all tested fractions, indicating that both mitochondrial and microsomal cytochrome P450s metabolize melatonin principally by 6‐hydroxylation, with O‐demethylation representing a minor metabolic pathway.


A persistent question for information technology researchers and practitioners is how big data analytics (BDA) can improve sales performance. Therefore, this study proposed a research model to investigate the impact of BDA on perceived sales performance in accordance with the resource-based view (RBV) and dynamic capability theory. The 416 valid responses collected from the employees of pharmaceutical organizations were analyzed using structural equation modelling to test the proposed research model. Results indicated that the BDA and customer relationship management (CRM) capabilities shared a strong positive impact on perceived sales performance. BDA, as organizational resources, creates organizational dynamic capabilities, such as CRM capabilities. BDA and CRM capabilities can influence perceived sales performance. Furthermore, CRM capabilities have a significant mediating impact on the relationships between BDA and perceived sales performance. This study also highlighted the practical and theoretical implications of the proposed model, the research limitations, and the future research directions.


Records Committee review for a Summer Tanager at Iowa City in Johnson County, IA on January 11, 1998. Includes a record review document with votes, a photo, an article in Field Notes, an article in Iowa Bird Life, an e-mail from Mary E. Noble to Jim Fuller, and two documentation forms submitted to the committee.


Abstract We study the previously developed extension of the Engel expansion to the field of Formal Laurent series. We examine three separate aspects. First we consider the algorithm in relation to the work of Ramanujan. Second we show how the algorithm can be used to prove expansions such as those found by Euler, Rogers, and Ramanujan. Finally we remark briefly on its use in acceleration of convergence.


Abstract Most companies have embraced the American Chemistry Council (ACC) Responsible Care" program, including Product Stewardship, and are integrating ISO 14001 and other environmental management systems. The Rohm and Haas Company uses environmental improvement objectives that not only focus on compliance with existing regulations and industry trends, but for developing business unit-driven objectives to reduce our environmental footprints for processes and systems. To attain the next level of strategic environmental management, integration of sustainable concepts and activities into a general management framework, new product development and corporate decision-making processes must occur. Businesses need to internalize that operating sustainably creates long-term value, achieves a greater competitive edge, and is not solely a short-term cost-reduction activity. They must recognize and foster implementation of technological advances in green chemistry, life-cycle analysis, risk assessment, and engineering consistent with specific business goals. Development of sustainability improvement objectives for each business unit assists in meeting our global sustainability goals. The process, measures and metrics, challenges, and results for integrating sustainability into the culture at Rohm and Haas will be described during this presentation.


This study investigated the effects of cognitive capacity and suspicion on veracity judgments. It was hypothesized that under low suspicion conditions, truth bias would be more pronounced when participants had low cognitive capacity than when participants had high cognitive capacity. One hundred and seven participants viewed presentations of people either truthfully or deceptively describing a series of pictures. Prior to the presentations, a short description designed to increase suspicion was read to half the participants. Participants viewed half of the presentations while working on arithmetic problems (low capacity) and the other half while not working on arithmetic problems (high capacity). Following each presentation, the participants were required to evaluate the communicator's performance on a number of scales and indicate whether the communicator was actually describing the picture. The results partially supported the hypothesis.


This paper is a presentation of a comparative study of the effect of water and kerosene coolants on surface finish during ultra-high precision diamond turning (UHPDT) of Rapidly Solidified Aluminium alloy (RSA 443). The percentage relative difference between the coolants' surface roughness values is denoted by the ΔRa parameter. The accuracy of the Response Surface Method (RSM) in predicting surface roughness of water and kerosene-based results is investigated in this paper. The cutting parameters used in the investigation are cutting speed, feed rate and depth of cut. The Taguchi method was used to design the experiment since it provides relatively fewer experimental runs when compared to classical experimental design methods. Mean Absolute Percentage Error (MAPE) values are used to compare RSM's surface roughness prediction accuracy on both water and kerosene-based results. It is observed that the surface roughness profiles for either coolant are similar, and the use of water coolant yields smoother surface finishes when compared to the use of kerosene. It is also observed that RSM displays better accuracy in predicting water-based surface roughness.


The conductivity has been measured between 55 mK and 4.2 K in zero field and in magnetic fields up to 7.5 T of a series of uncompensated {ital p}-type Si:B samples with dopant concentrations near the critical concentration for the metal-insulator transition. Acceptor wave functions, which are derived in silicon from the degenerate light- and heavy-hole {ital J}=3/2 valence-band maxima at {ital k}=0 and a spin-orbit-split {ital J}=1/2 band, are quite different from donor wave functions associated with the six degenerate conduction-band minima at different equivalent points in the Brillouin zone. Despite this, the conductivity of Si:B is found to be quite similar in many ways to that of Si:P. The critical conductivity exponent for Si:B is close to 1/2 as in Si:P and Si:As, rather than having the expected value of 1. The correction to the zero-temperature conductivity arising from electron-electron interactions is comparable in size, and the temperature dependence of the conductivity in various fixed magnetic fields is also found to be quite similar. For the range of dopant concentrations and experimental parameters of these investigations, the only important experimental difference between the two materials is the sign and size of the magnetoresistance. In contrast with Si:P, whichmore » has both positive and negative components, the magnetoresistance of Si:B is positive for all temperatures and magnetic fields studied. We attribute this to the strong spin-orbit scattering in {ital p}-type silicon associated with the degenerate valence bands.« less


Phonematic systems traditionally reconstructed by Indo-European Linguistics are practically unrecognizable in the data offered for the same questions by the Dynamic Typology. An analysis from this perspective shows that the phonematic system inherited from the different Indo-European languages was simpler than the systems traditionally defended. In order to have access to the original system from Indo-European languages a greater number of changes are necessary, which indirectly points to a date much prior to the Indo-European linguistics community period.


Objective To investigate the physiological features of patients with psoriasis vulgaris during sleep.Methods Thirty-six psoriasis patients were classified into the group with "blood-heat" syndrome(n=21) and the group with "blood-dry" syndrome(n=15).Fifteen healthy volunteers served as control.All the subjects underwent a nocturnal sleep examination using the micro-movement sensitive mattress sleep monitoring system(MSMSMS).The sleep indices and nocturnal heart rate dynamics of the patients were compared with that of the control,and also between the two groups with different syndrome.Results In comparison with the control group,both psoriasis patient groups showed the phenomena of poor sleep quality,such as the shallow sleep phase,disorder of sleep rhythm and increased slight-arousals.The slight-arousal occurred more often in blood-heat syndrome group than in blood-dry syndrome group,while the sleep latency was elongated more evidently in blood-dry syndrome group.Compared with the control group,the two patient groups presented a little decrease in heart rate(HR) after sleeping.However,the HR increased in the first phase of sleep,and the variation coefficient of HR increased in the whole sleep period.An increase in HR variation coefficient was more obvious in blood-heat syndrome group than in blood-dry syndrome group(P < 0.05).Conclusions The phenomena of decreased sleep quality and the variation of nocturnal HR in psoriasis patients may be due to the failure of Yin to control Yang,and disturbance of heat to the mind induced by blood-heat and Yin deficiency.The degrees of the phenomena are different between the two psoriasis groups.There is also a decrease in parasympathetic activity and relative increase in sympathetic activity in both psoriasis groups,with manifestation of different features in patients with different syndromes.


OBJECTIVE
To improve the method of inducing the multi-infarct dementia (MID) model in rats to observe the pharmacodynamic effect of Jiannao Yizhi (JNYZ) granule on MID.

METHODS
Retrograde injection with the homologous embolus through the external carotid artery initiated the multi-infarct dementia in rats. The experiment of behavior and morphology were conducted.

RESULTS
The extensive and multiple foci of infarction and the obviously declining ability of learning and memory were observed in the model group; the action of JNYZ granule and hydergine could obviously improve them.

CONCLUSION
This model is useful to carry out basic research and screen new drugs in treating MID.


Most building energy consumption dashboards provide a snapshot of building performance; others provide detailed historical data for comparison to current usage. This paper discusses the Building Agent platform, which was developed and deployed in a campus setting at the National Renewable Energy Laboratory as part of an effort to maintain the aggressive energy performance achieved in newly constructed office buildings and laboratories. The Building Agent provides aggregated and coherent access to building data, including electric energy, thermal energy, temperatures, humidity, and lighting levels, and occupant comfort feedback, which are displayed in various manners for visitors, occupants, facility managers, and researchers. This paper focuses on the development of visualisations for facility managers, or an energy performance assurance provider, where metered data are used to generate models that provide live predicted ranges of building performance by end use. These ranges provide simple, visual contexts for displayed performance data without requiring users to assess historical information or trends. Several energy modelling techniques were explo red, including static lookup-based performance targets, reduced-order models derived from historical data using main effect variables such as solar radiance for lighting performance, and integrated energy models using a whole-building energy simulation program. This paper describes the new building construction backdrop that has motivated this work, the system architecture providing access to building data, the various modelling approaches currently employed, and the visualisation methods used to display performance and modelled data.


Many of the current agriculture systems have deployed analog/digital sensors to measure crop monitoring, weather forecast, and environmental sensor data. The significant problems of the current agriculture system are 1) the inability to combine the collected sensor data into useful information for farmers to make the right decision to optimize the crop produce; 2) legacy infrastructure and manual data collection; 3) lack of scalability and incompatibility due to the vendor-dependent sensors and legacy data loggers. With the advent of the Internet of Things (IoT), the ad-hoc and traditional agriculture systems adopt precision agriculture methods to improve the quality and quantity of harvest. To realize such precision agriculture methods in Smart farming, we require a platform that collects the sensor data, processes it into information and helps in visualizing the results. The existing custom-made prototype solutions and the industry-grade data acquisition systems are expensive and have limited functionalities to realize the precision agriculture methods. In this thesis, we propose an architecture and testbed-based implementation for a cost-effective active data acquisition system that can autonomously collect, transmit, and process the raw data. The proposed architecture includes four modules Nodes, Aggregators, Cloud-based Database, and Client-side applications. The functionalities of these modules are 1) Node collects sensor data at specified intervals and transmits the sensor data streams to the aggregator; 2) Aggregator executes a data serializer for converting the sensor data streams, buffer for local storage, and data transmitter for sending them to the cloud-based database system; 3) Cloud-based Database is hosted on Amazon Relational Database Services (RDS) and uses Postgres SQL to facilitate multiple reads, write, and no overwrite functionality; and 4) Client-side applications include web pages, mobile apps, and services that communicate the cloud-based database system for the field sensor data. The test-bed was set up at the Iowa State University greenhouse environment to read controlled environmental data. Collected data from a commercial sensor validated the measurements


All the modern concept of VCA ( internal control) provide some of the same but different their accents, terminology and methods to a degree certain other areas of control and depth of implementation systems management. In this regard, the concept of focus VCA purpose of lean production aimed at fighting losses of all kinds and in all areas of the company.


Solid State Transformer (SST) is the main focus of research in recent years. Bidirectional Isolated Dual Active Bridge is an important component in SST. When conventional control scheme such as Single Phase Shift (SPS) is used it reduces the system efficiency due to circulating power and has high dv/dt across switches. It has only one degree of freedom which confine its ability to regulate power flow. In this paper, 5-level Dual Active Bridge is proposed with three degree of freedom which improves its ability to regulate power flow. Moreover due to increase in voltage levels, dv/dt across switches reduces significantly and it also reduces the circulating power which improved the efficiency of system. Performance of the proposed topology has been varified in MATLAB.


The hypothalamus controls glucose and lipid metabolism in peripheral tissues. Recent studies have revealed that the ventromedial hypothalamus (VMH) and arcuate nucleus (ARC) of the hypothalamus play an important role in the regulation of glucose and lipid metabolism in skeletal muscle and the liver. The fat-derived hormone leptin was thus shown to stimulate glucose uptake and fatty acid oxidation in red-type skeletal muscle by activating VMH neurons - likely mediated in part by augmentation of synaptic plasticity between leptin receptor and proopiomelanocortin (POMC)-expressing neurons in the ARC and melanocortin receptor (MCR)-expressing VMH neurons - and consequent activation of sympathetic nerves innervating the muscle tissue. The VMH - sympathetic nerve axis was also found to be activated by orexin-positive neurons in mediation of hedonic feeding-induced glucose uptake in red-type skeletal muscle. The effects of orexin and leptin on glucose metabolism in skeletal muscle are interconnected with those of insulin, with the action of VMH also being necessary for the beneficial effects of exercise on metabolism. Leptin ameliorates diabetic phenotypes in animals with uncontrolled insulin-deficient diabetes as well as in patients with or animal models of lipodystrophy through the central nervous system (CNS). Finally, a single injection of fibroblast growth factor 1 (FGF1) into the lateral ventricle was shown to induce sustained remission of hyperglycemia in several animal models of type 2 diabetes, at least in part by increasing glucose uptake in skeletal muscle. The CNS thus plays an important role in the control of glucose and lipid metabolism, with the VMH as well as POMC neurons being implicated as key regula-tors of such metabolism in skeletal muscle.


Detecting vehicles in aerial images provides important information for traffic management and urban planning. Detecting cars in aerial images is challenging due to the relatively small size of the target objects and the complex background in man-made areas. It is particularly challenging if the goal is near real-time detection within few seconds on large images without any additional information, e.g. road database, accurate target size. We proposed a system which can detect the vehicles on aerial video. Beside the bounding box of the vehicles we also extract an orientation and type (car/truck) information. First we classify vehicles as car or truck depending on the size of the bounding box obtained in first step. In the next step we also estimate the orientation (Right or Left) of the vehicle by comparing shift in the centroid of the vehicle. We evaluate our method on a dataset of original aerial video from a UAV (Unmanned Aerial Vehicle). Keywords—Component; Formatting; Style; Styling; Insert


Hexanucleotide expansions within the first intron of the C9ORF72 gene are a significant cause of familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), alone or in combination, as well as sporadic ALS worldwide.1–3 Several recent reports have described cases which broaden the clinical phenotype to include behavioral variant FTD with or without early psychiatric presentations and parkinsonian features,4,5 and primary progressive aphasia.6 There is also a report of a patient with a family history of ALS and cerebellar ataxia,5 an intriguing finding as neuroimaging of C9ORF72 patients shows cerebellar atrophy, which is not typically observed with other FTD-related mutations such as MAPT or GRN.7 Cerebellar neuronal cytoplasmic inclusions have also been observed in multiple studies,6,7 yet clinical cerebellar ataxia has not been detected in any large cohorts of C9ORF72 patients with FTD and/or ALS.1–3,7 Since a majority of adult-onset ataxia cases are of unknown etiology, these observations raise the possibility that C9ORF72 may contribute to the development of sporadic spinocerebellar ataxia.

To address this question, we examined 209 adult-onset sporadic ataxia patients for C9ORF7 hexanucleotide expansion (Table I). All patients were screened for common genetic spinocerebellar ataxias including SCA1, SCA2, SCA3, SCA6, SCA7, and/or Friedreich ataxia. Most patients (40%) had pure cerebellar ataxia but, given the known C9ORF72 phenotypes, cases associated with upper motor neuron signs, dementia, and parkinsonism were also included. Approximately one-third of these patients met possible or probable criteria for multiple system atrophy. Testing was performed as previously described3 and only one positive case was identified (1/209, 0.5%).

Table

Patient Demographics (N=209).

This patient, currently age 53, developed slowly progressive cerebellar dysfunction in her early 20's with falls by age 25. Upper motor neuron features of increased lower extremity tone and hyper-reflexia were present but annual assessments have shown no lower motor neuron involvement or cognitive decline. MRI has shown cerebellar atrophy with no frontal or temporal involvement. Evaluation for other genetic causes involving the APTX, ATN1, ATXN1, ATXN2, ATXN3, ATXN7, ATXN8, ATXN10, CACNA1A, FMR1, FXN, KCNC3, PRKCG, PP2R2B, SACS, SETX, SPTBN2, and TBP genes was unremarkable. She is Caucasian with French-Canadian ancestry. As with the prior reported C9ORF72 ataxia case,5 family history was notable for her father and paternal uncle being diagnosed with ALS and dying within 2 years of symptom onset. There were no other affected family members.

We speculate that the clinical findings seen in our patient represent a rare (<1%) C9ORF72 phenotype,5 however, given the lack of other affected family members or unrelated cases, we cannot confirm this. C9ORF72 penetrance varies by age, with full penetrance occurring by the 9th decade,1 and it is possible that our patient will still develop a more classic phenotype. Regardless, this study does not support genetic testing for C9ORF72 expansion in sporadic spinocerebellar ataxia, although, as our study only examined sporadic-onset cases, it remains possible that C9ORF72 may contribute more significantly to dominant familial forms. For now, C9ORF72 testing would only be indicated for ataxia patients with a family history of ALS and/or FTD.


Hydro generation scheduling with complicated discrete dynamic operating constraints and multiple operating zones is extremely difficult. One of the most important problems is to identify the feasibility of a hydro unit commitment and to construct a feasible solution efficiently. This paper focuses addressing the issues of the hydro generation scheduling problem with a single hydroelectric plant and several units and multiple operating zones. Based on analysis of the structure of water conservation equations, a necessary and sufficient condition on the problem feasibility is presented and is applied in constructing feasible solution as efficient tool. Its application for generating efficient cutting planes in mixed integer programming problem is discussed. The theoretical results are also validated by numerical examples.


In the liquid crystal device of reflective semi-transmission type, while fully securing the visibility of the image due to the transmissive display, thereby improving the visibility of the image by the reflection type display. The liquid crystal device 10 includes a color filter substrate 300, reflective portion (301b) for reflecting of the incident light from the counter substrate 200 side provided on the surface facing the liquid crystal layer 165 toward the opposite substrate 200 and the , and the color filter substrate, the opening (301a) for transmitting incident light from the 300 side toward the counter substrate 200 has a reflective layer 301 that separates the respective pixels (160). The pixel region 160 is provided, is divided into a plurality of blocks when viewed from the direction perpendicular to the plate surface of the counter substrate 200, and the area of the opening (301a) different from each small region. In a small region smaller area of the opening (301a), which is more than the amount of light which is reflected by the reflective portion (301b) other than the predetermined area is a large area of the opening (301a) is increased.


Background Cadherin-11, a cell-to-cell adhesion molecule, is associated with higher tumor grade and decreased patient survival. The purpose of this study was to investigate the clinical significance of cadherin-11 expression in the progression and prognosis of a newly diagnosed primary glioblastoma (GBL). Methods Between 2007 and 2016, 52 out of 178 patients diagnosed with a GBL and satisfied the following criteria: 1) a new primary GBL, 2) gross-total resection, 3) immunohistochemically-available tissue, and 4) standardized adjuvant treatment. Results In terms of staining intensity, the low-intensity cadherin-11 group showed longer progression-free survival (PFS) than the high-intensity cadherin-11 group (median PFS, 12.0 months [95% CI, 11.1–12.9] vs. median PFS, 6.0 months [95% CI, 3.7–8.3]; p<0.001). The low-intensity cadherin-11 group revealed longer overall survival (OS) than the high-intensity cadherin-11 group (median OS, 20.0 months [95% CI, 11.8–16.6] vs. median OS, 15.0 months [95% CI, 11.8–18.2]; p=0.003). The staining intensity of cadherin-11 was a statistically significant factor in PFS and OS in terms of univariate and multivariate analyses (univariate analysis: p<0.001 and p=0.005; multivariate analysis: p<0.001 and p=0.005). Conclusion Our clinical study demonstrates high cadherin-11 expression may be associated with poor PFS and OS for a newly diagnosed primary GBL.


ABSTRACT Collembola Poduromorpha Börner, 1913 belonging to the families of Hypogastruridae Börner, 1906, Brachystomellidae Stach, 1949, Neanuridae Börner, 1901 and Onychiuridae Lubbock, 1867 from Yemen were studied. A new species, Xenylla vanharteni n. sp., is described with the combination of following characters: 5 + 5 eyes present, mucro separated from dens and chaetotaxy of "bgklort" type. Remarks to the original description of Penelopella pohli (Barra, 2006) n. comb. is presented. New localities for seven further species are given.


Some of the basic characteristics of tissue mast cells were described over 140 years ago by Paul Ehrlich, the founder of modern immunology [...].


We present a general method based on the investigation of the relative energy of the system, that provides an unconditional error estimate for the approximate solution of the barotropic Navier–Stokes equations obtained by time and space discretization. We use this methodology to derive an error estimate for a specific DG/finite element scheme for which the convergence was proved in [1]. The talk contains material from two recent papers [2] and [3]. T.K. Karper. A convergent FEM-DG method for the compressible Navier-Stokes equations. Numer. Math. 125(3) :441–510, 2013. T. Gallouet, R.Herbin, D.Maltese and A. Novotny. Error estimate for a numerical approximation to the compressible barotropic Navier-Stokes equations. IMA Journal of Numerical Analysis, to appear E. Feireisl, R. Hosek, D. Maltese and A. Novotny. Error estimates for a numerical method for the compressible Navier-Stokes system on suficiently smooth domains, Preprint


English Self-efficacy is a self-confidence in English proficiency which is important to student behaviour on learning process. This study aims to investigated the role of english self efficacy in mediating the relationship between mastery goal orientation and student engagement on learning English. The method was quantitative using survey approach with 173 subjects. The subject was 173 students of 10th and 11st grade in SMA Negeri 9 Yogyakarta in 2016/2017 selected by purposive sampling technique. The Morgan-Jinks Student Efficacy State modification scale, student engagement modification scale, and mastery goal orientation scale were used in this study. The result showed that English self-efficacy was partially mediated. The mastery goal orientation directly had positive role to the student engagement (B= 0,468; p<0,001). The mastery goal orientation had positive role to the student engagement on learning English with self-efficacy as mediator (B'=0,369; p<0,001), English self-efficacy on boys were higher than girls.


This paper first offers a glimpse of syntax research,then discusses the goals,principles and methodology of cognitive syntax,finally makes a general comparison between cognitive syntax and Chomsky's syntax.In such a manner we can obtain a very basic picture concerning the actual operating mechanism of this fresh perspective in syntactic studies and meanwhile a plausible framework in this field is more tangible.


A condition is derived in order that charge-exchange losses be negligible in a mirror plasma-confinement experiment in which the plasma is sustained by neutral injection in steady state. The condition is more severe than the 'burnout' condition that neutrals be screened out of the plasma interior.


The clinical diagnosis of behavioral variant frontotemporal dementia (bvFTD) in patients with a history of primary psychiatric disorder (PPD) is challenging. PPD shows the typical cognitive impairments observed in patients with bvFTD. Therefore, the correct identification of bvFTD onset in patients with a lifetime history of PPD is pivotal for an optimal management.


Empirical likelihood has been found very useful in many different occasions. However, when applied directly to some more complicated statistics such as U-statistics, it runs into serious computational difficulties. In this paper, we introduce a so-called jackknife empirical likelihood (JEL) method. The new method is extremely simple to use in practice. In particular, the JEL is shown to be very effective in handling one and two-sample U-statistics. The JEL can be potentially useful for other nonlinear statistics.


This review covers the solubility of oxygen and ozone in liquids as a function of temperature and pressure. Solubility data for individual systems were critically evaluated and recommended or tentative values presented in many cases. The trend of solubilities in homologous series or related solvents is discussed. Liquids include water; seawater; aqueous salt solutions; mixed solvents; hydrocarbons; organic compounds containing oxygen, halogen, sulfur, nitrogen, or silicon; olive oil; and human blood. For ozone, only its solubility in water is presented. Key words: aqueous solutions; biological fluids; gas solubility; hydrocarbons; mixed solvents; organic solvents; oxygen; ozone; seawater; water.


Intelligent Transportation System (ITS) is a most promising method in dealing with the traffic problems. One of the key problems of ITS is the analysis and management of traffic information. First, characters of ITS information and requirements for analyses are introduced; second, the shortcomings of the common methods which are usually used nowadays in information analyses and decision support indicated. An integrated system model of ITS information intelligent analysis and the decision support based on the decision support system theory of new era and computing intelligence techniques are given. In the mean time, the pivotal techniques and its realization schemes are discussed.


The aim of the study is to find the best approaches to the treatment of infantile hemangiomas (IH). Materials and methods of research: the experience of treatment of pediatric patients with IH of various localization is presented, which was carried out according to the protocol elaborated by the authors. Systemic therapy with propranolol, local therapy, laser therapy were used in the complex of treatment. The age of patients at the beginning of therapy ranged from 1 month up to 4,5 years. Results: in all cases, patients with propranolol treatment showed a quick and stable effect. Even at the time of the selection of the dose of the drug, IH patients began to involute, became paler, less tense. The thickness of the soft tissues in the IH area decreased by 65% compared to the baseline, the number of functioning vessels decreased by 86%. The maximum effect was achieved within the first 6 months from the start of therapy. Clinical case report – a 2,5-year-old child with extensive hemangioma of the right buttock. There was a complex treatment with propranolol, local therapy, laser therapy. The general course of treatment with propranolol was 2 years 8 months. The total number of laser interventions was 6 with the overall effect in the form of maximum regression of residual clinical manifestations of IH. A positive clinical and ultrasound picture was noted, indicating a pronounced involution of IH, and a gradual withdrawal of propranolol was started. Conclusion: the effectiveness of a comprehensive interdisciplinary approach to the treatment of extensive complicated IH was demonstrated with the participation of specialists of various disciplines: pediatricians, cardiologists, surgeons, specialists in functional and ultrasound diagnostics, specialists in laser therapy, endocrinologists in a severe premature baby with a large number of somatic problems. The clinical treatment algorithm developed and implemented for patients with IH makes it possible to avoid more aggressive methods of treatment of this pathology and to improve the quality of life of this category of patients. On the basis on the results obtained, indications for laser therapy with a selective pulsed laser were formulated.


The utility model provides a speed reducer of a lifting device. The speed reducer of the lifting device integrates with the function of overload protection, the function of stroke control and the function of manual input. A safe load is set through an adjusting screw rod. When output torque exceeds the set safe load, axial displacement happens to a worm to squeeze a spring, a spring sleeve touches an overload protection safety switch, and output is stopped; when an output shaft of the speed reducer of the lifting device is lifted to the set stroke position, a stop lever on a lead screw touches a stroke control switch, so that the function of stopping, the function of inverted output, the function of decelerating output and the like are achieved, under the condition of power failure or other specific conditions, the device can not be driven, and the lifting device can be driven manually through a hand crank.


This paper has given a detailed discussion of the recent trend for analyzing the reliability of safety related systems. The trend with the latest developments in the field of reliability is seems to have turned from a qualitative analysis to a quantitative analysis. For this purpose the authors of this paper have put forward some methods both of qualitative and quantitative nature in hoping to emphasize one of the most useful and comprehensive quantitative techniques-Markov analysis. To overcome one of the disadvantages of this method-the explosion scale of Markov model, the paper has made its own corresponding improvements, known as micro Markov analysis. And, finally, it has made a detailed analysis on the prosperity of the application of the method on reliability analysis.


Ulcerative colitis (UC) is a common inflammatory bowel disease. The importance of experimental models for investigating the pathogenic mechanisms and assessment of potential therapeutic agents for UC is well established. Betulin is a natural triterpene compound that has been reported to exert wide spectrum of pharmacological and biological activities.


This Review Essay is brought to you for free and open access by the Tampa Library at Scholar Commons. It has been accepted for inclusion in Genocide Studies and Prevention: An International Journal by an authorized administrator of Scholar Commons. For more information, please contact firstname.lastname@example.com. Recommended Citation Mazzucelli, Colette (2014) "Humanitarian Technologies and Genocide Prevention: A Critical Inquiry," Genocide Studies and Prevention: An International Journal: Vol. 8: Iss. 3: 87-99. DOI: http://dx.doi.org/10.5038/1911-99220.127.116.11


Totem-pole FC has the potential to achieve high efficiency and power density by using GaN HEMTs as the high-frequency switching device. With the advent of 600-650V rated commercial GaN HEMTs, the totem-pole PFC is expected to emerge as the dominant topology for the front-end of telecom and data center power supplies. Like most bridgeless topologies, totem-pole PFC generates a large amount of common-mode (CM) noise. Especially around the zero-crossings of input line voltage, the noise is very prominent and a huge current spike is also observed in the input current. A few existing works have theorized about the origin of the CM noise and the spike current but they lack the proper explanation to relate these two mutual issues and estimate the influence of different circuit parameters. The objective of this work is to establish the relationship between these two issues, primarily through the investigation of practical waveforms and a modified CM noise model. To facilitate the design of the totem-pole PFC with reduced EMI, a set of mathematical equations are also developed from a proposed equivalent circuit. Finally, the contribution of different circuit parameters on CM noise and spike current generation at zero-crossing is identified and outlined from the analysis of the equivalent circuit.


Limb transplantation is considered to be a treatment option for amputees. Visual skin inspection and histological assessment are used to assess rejection, but these techniques are largely subjective. Using a rat model, we examined the potential of several microRNAs (miRNAs) to be used as objective and minimally invasive biomarkers of acute rejection of transplanted limbs.


Introduction The Late Paleozoic Ancestral Rocky Mountains (ARM) formed in western equatorial Pangea. Although this system has been the focus of significant research efforts, several basic aspects of its climatic and tectonic setting remain obscure. A key issue bearing on and linking both climatic and tectonic considerations is the topography of the system (cf. Chase et al., 1998). Specifically, how high were the mountains? Citing the thick, coarse clastics that mantle many of the classic ARM uplifts, Mallory (1972a) postulated elevations of 1500-3000 m, although paleoaltimetry is difficult to estimate owing to uncertainties regarding relative rates of uplift, denudation, and subsidence. Mack et al. (1979) first discussed the ARM in the context of its lowlatitude position, and suggested geographically controlled climatic variations in the vicinity of the ARM, implying elevations significant to create orographic effects. More precise estimates of paleoaltimetry, however, have been elusive. Here, we present preliminary evidence for alpine-type glaciation in parts of the equatorial ARM. Confirmation of our hypothesis implies at least locally high elevations for the ARM, assuming a climate system similar to the modern.


As an effective tool, reinforcement learning (RL) has attracted much attention in the field of mobile edge computing (MEC). For MEC task offloading, we hope to find a high-quality task offloading strategy faster. The Policy Gradient (PG) algorithm, as one of the RL algorithms, is known for its fast convergence. And the PG algorithm does not need to consider the state transition, and can run directly to get the result. In a queuing task scenario of a single terminal and a single edge server, the PG algorithm can quickly obtain a high-quality offloading scheme. The Greedy algorithm is also a commonly used decision-making method in MEC task offloading. Thus, we use the Greedy algorithm as the experimental control group and compare it with the exhaustive algorithm. Through the simulation platform, it can be judged that on the basis of randomly taking the initial value, the PG algorithm can save more than 50% of the overhead. Although the Greedy algorithm has advantages when the number of tasks is small, as the number of tasks increases, the overhead of the Greedy algorithm will become higher and higher due to the long decision time. Therefore, the PG algorithm is more effective in our scenario, which can obtain a high-quality offloading scheme through a shorter decision time. complexity.


Several clinical and animal studies have demonstrated that pulsatile perfusion is more beneficial than nonpulsatile perfusion during short or long durations of extracorporeal circulation. Other investigators, however, have been unable to document these benefits. The issue remains controversial. Central to the debate is the issue of a precise definition of pulsatile flow. To help resolve the conflict, pulsatile flow may be quantified in terms of energy equivalent pressure. This formula contains both the arterial pressure and pump flow rate, which are the 2 most critical parameters for open heart surgery. This definition establishes common criteria for assessment of the effectiveness of extracorporeal support.


Coated oxide particle, composed of a metal oxide core and a silicon dioxide shell that surrounds the core, characterized in that it shows the absence of an end point in the absorption of dibutyl phthalate, a photo-catalytic activity, determined by oxidation of 2-propanol in acetone, less than 0, 20 or 10- 3 molukg-1umin-1, a BET surface, determined according to DIN 66131, between 5 and 600 m2 / g, a primary particle size between 2 and 100 nm and a secondary particle size between 0.05 and 50 m, and a silicon dioxide shell layer thickness between 0.5 and 25 nm, in which the metal oxides comprise titanium dioxide, zinc oxide, oxide Zirconium, iron oxide, cerium oxide and / or chemical mixtures of these metal oxides with each other, and / or chemical mixtures of these metal oxides with aluminum oxide, and / or chemical mixtures of these metal oxides with silicon dioxide.


As HDTV (High Definition Television) services are the next big thing in the television broadcasting, the work for the next generation terrestrial Digital Video Broadcasting (DVB-T2) standard has started. Since HDTV channels require more capacity, new technologies as compared to current terrestrial DVB-T standard are necessary. One improvement is to select a more efficient Forward Error Control (FEC) code. A potential candidate for this is the Low Density Parity Check (LDPC) code specified in the in the DVB-S2 (second generation satellite Digital Video Broadcasting) standard. It is stated in the call for technologies issued by the DVB project, that this code is the working assumption. It is further stated that if the DVB- SI LDPC code is not suitable for terrestrial channels, other channel coding schemes could be considered. In this paper the performance of a system where DVB-T concatenated Reed-Solomon-convolutional coding scheme is replaced by the DVB-S2 LDPC code is studied by simulations. The aim is to investigate the performance of the LDPC code in a terrestrial channel model.


Nowadays, the Computational Fluid Dynamics (CFD) represents a standard design practice in solving the ship hydrodynamics problems, worldwide. In recent years CFD is actively in used by numerous maritime design organizations and related educational institutions. CFD is applied for propulsion research of the new-built or modernized ships, as it is well suited for the practice in the design and optimization of the ship hull form. The presented results are also including the verification/validation analysis of the KCS hull form from the Gothenberg-2000 workshop has been developed by the authors of this paper, and through this comparative study, the best practices learned in this process, are shown. In this paper the FlowVision code is used as the CFD tool, integrating a new method of in-detail hull form design based on the wave-based optimization. The hull form design and its optimization are based on the systematic variation of the longitudinal distribution of the hull volume, while the vertical volume distribution is fixed or highly controlled. Such design process is underpinned with the respective data analysis of the obtained results, which are presented as the optimum distribution of the required hull volume. The final result is the optimized designed hull form, which shows interesting characteristics, as its resistance has decrease by 8.9% in respect to the well-known KCS hull form. While the computing capabilities were rising, another CFD approach based on numerical solving the differential equations of viscid flow (Navier-Stokes equations) was developed. In general, these equations may be solved by the numerical Finite Element (FE) or Finite Volume (FV) methods, but direct approach puts heavy demands on the resources needed for the practical projects. Therefore, special numerical methods based on the Navier-Stokes equations were developed to simplify the problem, with the objective to decrease the computational effort. At the present time, a method of solving the Reynolds-Averaged NavierStokes equations (RANS) is the most popular one used in the practical ship hydrodynamics. This promising approach provides flexible and exact simulating conditions, which made them very popular since 2000s. An example of more detailed historical overview can be found in the book (Larsson & Raven 2010). According to the materials of the Gothenburg 2010 Workshop on Numerical Hydrodynamics (Larsson et al. 2011), there are about 20 software packages, which allow high precision modeling of the viscid hull flow with a free surface. Some of them are well-known commercial products;


In this paper, we design the so called  "Strong Diffie-Hellman-Exponential-Schnnor Key Exchange (called SDH-XS-KE)"over Elliptic curves. SDH-XS-KE is a key echange protocol proposed in 2014. The protocol SDH-XS-KE improves the"Strong Diffie-Hellman-DSA Key Exchange (called SDH-DSA-KE)" proposed by Jeong and al. in 2007. First SDH-XSKE is designed in finite groups such that Z=pZ where p is a prime number. So, in this paper, we present the elliptic curves version of the protocol SDH-XS-KE.


Most research into international marketing focuses on the differences in markets across countries and cultures in terms of the variation in customers and products involved. Arguably, if different products are developed and offered to different customers, then the roles and requirements of marketing employees may reflect these differences also. This research study used self-report measures by marketing employees in a large multinational automotive company in Australia and Britain. Using structural equation modelling, the study found that the relationship between individual marketing competencies and marketing performance varied across countries, suggesting that there may be cultural differences that influence both the role of managers in improving performance, and the degree to which a marketing employee's intention to perform results in actual performance.


Computer simulation is widely-used in investigating the performance of existing and proposed systems in many areas of science, engineering, operations research, and management science, especially in applications characterized by complicated geometries and interaction probabilities, and for dealing with system design in the presence of uncertainty. This is particularly true in the case of computer systems and computer networks. Therefore, it is very important to have efficient, reliable, and accurate methodologies for simulating these systems to ensure effective, reliable, and accurate evaluation and analysis of performance and to create the optimum design parameters for communication and computer networks. Although practical experiments and simulations are the most widely used, several efforts have also been directed towards mathematical models. The main objectives of this chapter are to: present the methodologies and techniques used to evaluate and analyze the performance of communication and computer networks routers, such as mathematical analysis, computer simulations techniques, and empirical measurements; identify the workload required for accomplishing a simulation model or mathematical analysis; identify the main metrics used to evaluate, manage, and control the performance of the computer networks; present the advantage and disadvantage of these techniques; and identify the challenges facing these different methodologies.


This bachelor thesis aims to determine whether university education affects the integration of nurses into the medical team. The theoretical part of the thesis deals with the current system of nursing education, the different categories of health workers and last but not least, their process of adaptation. A significant part of the work focuses on teamwork, since it is an important factor that influences the process of integration of nurses in the workplace. In the practical part determined through a questionnaire survey views on university education from the perspective of nurses with different levels of educational attainment. Results of the questionnaire survey is beneficial to practice primarily in that it identifies the main factors that influence the integration of nurses into the work team. The result of the survey will be published in a journal that informs about news in health care.


We propose a novel 3D face recognition algorithm using a deep convolutional neural network (DCNN) and a 3D face expression augmentation technique. The performance of 2D face recognition algorithms has significantly increased by leveraging the representational power of deep neural networks and the use of large-scale labeled training data. In this paper, we show that transfer learning from a CNN trained on 2D face images can effectively work for 3D face recognition by fine-tuning the CNN with an extremely small number of 3D facial scans. We also propose a 3D face expression augmentation technique which synthesizes a number of different facial expressions from a single 3D face scan. Our proposed method shows excellent recognition results on Bosphorus, BU-3DFE, and 3D-TEC datasets without using hand-crafted features. The 3D face identification using our deep features also scales well for large databases.


The paper investigates the concept of salience as applied to lexical semantics. More precisely, it looks at whether one can speak of salience in the semantic features of a given meaning. A pilot study is conducted, in which the different meanings of a polysemous phrasal verb, take off, are described in terms of semantic features. Those features are then compared to each other so as to find out if some can be said to be more salient than others. They are given gradients of salience, making it possible to represent graphically this salience in each meaning. Tentative conclusions are then drawn. It is claimed that it is possible to reintroduce semantic features into the analysis of meaning, though not of the same type as in Componential Analysis (Nida, 1975). Also, different degrees of salience for semantic features might explain some different aspects of a given meaning, as described by Cruse (2001) in terms of facets.


Background/Aim: B10 cells are generally considered to inhibit the kidney injury in systemic lupus erythematosus (SLE) mouse models, but recently this function of B10 cells was denied by the lineage-specific deletion of IL-10 from B cells. Thus, this study aimed to determine whether and how B10 cells play a protective role in lupus nephritis (LN). Methods: LN and non-LN SLE patients without receiving any treatments were recruited, and the percentages of circulating B10 cell were determined. Furthermore, the purified B10 cells were transferred into MRL/lpr SLE mice, and the exact effects of B10 cells on LN progression were investigated. Results: The percentage of circulating B10 cells was significantly higher in patient than in healthy controls, while they were fewer in LN patients than non-LN SLE patients. Moreover, B10 cells rather than plasma IL-10 levels were negatively correlated with disease severity especially with kidney injury in LN patients. In animal experiments, the glomerular injuries including the proteinuria and pathological scores were significantly attenuated in SLE mice transferred with B10 cells, accompanied by the decreased glomerular endothelial cell CD54/CD106 expression, and glomerular p38 phosphorylation as well as increased SOCS3 expression. At the same time, the serum anti-dsDNA autoantibody, TNF-α and IFN-γ levels were also reduced, while there were no changes in serum IL-10 and IL-17 levels in B10 cell transferred mice. Conclusion: These findings suggest that B10 cells could - independent from IL-10 - ameliorate glomerular injury in LN through protection of glomerular endothelial cells.


Bibliometric analysis of 539 articles published in the journal titled "Dental Clinics of North America" during 2004 to 2014 has been carried out. The paper analysed yearwise distribution of paper, average length of paper, authorship pattern, bibliographic form of documents, distribution of citations and subject trends of articles. The result shows that the journal on an average has published 49 research articles per year and most of the papers were contributed by two authors. Most of the articles dealt with general dentistry. The average length of the paper is 17 pages per article and journals are the most predominant form of citations.


Reduced oxygen levels (mild hypoxia) in aircrew, due to reduced cabin pressure equivalent to an altitude of 8000ft in most commercial aircraft or up to 12,000ft in some military aircraft, could impair their complex cognition, including decision-making, and mood (see references). This could be a latent safety hazard for most routine flights, particularly when aircrew may have subtle and complex decisions to make whilst faced with high workloads in novel, difficult or emergency situations. The present study was designed to explore the effects of mild hypoxia on complex cognition and mood using a battery of psychological tests that drew on some of the complex cognitive capacities, including decision-making, that are common in a wide variety of real-world situations by pilots. We hypothesized that some of the cognitive tests selected for the study would be affected by altitude on account of their complexity and novelty and because they involved multiple demands. The study also explored the efficacy of a potential practical 'simple fix' (i.e. the use of supplementary oxygen) in which it was hypothesized that cognition and mood would be restored to normal levels.


Syriac belongs to the Semitic family of languages, and is a dialect of Aramaic. The history of Aramaic goes back to the second millennium B.C. It was "first attested in written form in inscriptions of the tenth century B.C., it still continues to be spoken and written in the late twentieth century A.D. by a variety of communities in the Middle East and elsewhere. At various times over the course of these three thousand or so years of its known history, Aramaic has been spoken or written by peoples of many different faiths, by pagans, Zoroastrians, Buddhists, Manicheans, Jews, Samaritans, Mandeans, Christians and Muslims".


This paper discusses four interaction design patterns that constitute assistive solutions to enhance the accessibility of audible and visual information inside learning environments. These patterns result from a content analysis of 118 video environments that were designated for learning. The analysis yields a pattern language of currently 40 patterns that describes common solutions of recurring problems in the design and development of video learning environments. Beside the complete representation of the accessibility patterns Closed Captions, Transcript, Zoom, and Shortcut Commands, this paper draws attention to possible ways of structuring the pattern language.


The effects of the two major space-related conditions, microgravity and radiation, on the maintenance and transmission of genetic information have been partially documented in many organisms. Specifically, microgravity acts at the chromosomal level, primarily on the structure and segregation of chromosomes, in producing major abberations such as deletions, breaks, nondisjunction, and chromosome loss, and to a lesser degree, cosmic radiation appears to affect the genic level, producing point mutations and DNA damage. To distinguish between the effects from microgravity and from radiation, it is necessary to monitor both mitotic and meiotic genetic damage in the same organism. The yeast Saccharomyces cerevisiae is used to monitor at high resolution the frequency of chromosome loss, nondisjunction, intergenic recombination, and gene mutation in mitotic and meiotic cells, to a degree impossible in other organisms. Because the yeast chromosomes are small, sensitive measurements can be made that can be extrapolated to higher organisms and man. The objectives of the research are: (1) to quantitate the effects of microgravity and its synergism with cosmic radiation on chromosomal integrity and transmission during mitosis and meiosis; (2) to discriminate between chromosomal processes sensitive to microgravity and/or radiation during mitosis and meiosis; and (3) to relate these findings to anomalous mitotic mating type switching and ascosporogenesis following meiosis.


Dy‐doped borate glasses with PbO and PbX2 (X = F, Cl) were examined using Raman and luminescence spectroscopy. The Raman spectra show the structural changes of a glass network with B2O3/PbO ratios and presence of PbX2 (X = F or Cl). The photoluminescence spectra measured in the visible range present two bands located at 480 and 573 nm, which correspond to 4F9/2–6H15/2 (blue) and 4F9/2–6H13/2 (yellow) transitions of Dy3+. Luminescence decays from the 4F9/2 state and yellow/blue luminescence intensity ratios (Y/B) were analyzed as a function of glass composition (B2O3/PbO) and PbX2 (X = F, Cl) content. The branching ratios of yellow/blue luminescence increase, whereas the 4F9/2 lifetime of Dy3+ ions decreases with increasing PbO concentration. An introduction of PbX2 to the borate glass results in the increasing of 4F9/2 lifetime and decreasing of the yellow‐to‐blue luminescence intensity ratio. These phenomena are related to reduction of covalency between Dy3+ and O2−/X− ions.


The liquid crystal display device is disclosed which, while using an artificial light and natural light to display an image array substrate and a method for achieving a wide viewing angle, and this. The array substrate includes a pixel electrode and the reflective portion. The pixel electrode has the opening pattern is formed to define a plurality of liquid crystal domains in the unit pixel area. Reflecting part is formed at the domain boundary region. Accordingly, by defining a plurality of domains corresponding to the domain boundary region of an array substrate employing a wide viewing angle mode, by utilizing By forming the reflection domain boundary region in the reflective region to achieve a wide viewing angle with improving the display quality can.


Background: The first-degree relatives (FDRs) of patients with colorectal cancer (CRC) are at a 2 to 3-fold increased risk of developing the disease compared with the general population. Objectives: This study aimed to determine the relationship between the lifestyle of colorectal cancer patients' FDRs and their compliance in colonoscopy screening test. Methods: This cross-sectional study conducted on FDRs of patients with colorectal cancer in one educational hospital, Tehran, Iran in duration 2018. A total of 114 patients' FDRs were consulted face to face by preventive medicine specialist and data collecting forms were fully completed. Three months later the FDRs were followed for undergoing colonoscopy screening test or decision to do it soon. Next, the relationship between lifestyle [BMI (body mass index), cigarette smoking, diet, physical activity], socioeconomic status (job, income, health insurance), and comorbidities with a tendency to participate in colonoscopy screening program assessed. In multivariable logistic regression analysis, predictor factors for colonoscopy screening in FDRs were investigated. The data were analyzed using SPSS V. 18 software and the significance statistically was P < 0.05 in the all tests. Results: Overall, 57% of FDRs undergone colonoscopy tests up to time of study or they were tended to do it soon. In multivariable logistic regression, age < 50 years old (P = 0.01, OR = 1.08, 95%CI: 1.01 - 1.8), higher income (equal and more than 20 million Rials) (P < 0.001, OR = 2.5, 95%CI: 1.8 - 11), appropriate physical activity (≥ 150 minutes weekly) (P < 0.001, OR = 5.2, 95%CI: 4.6 - 17.5) and normal diet (intake of carbohydrate, fat, protein, fruit and vegetables) (P = 0.006, OR = 3.02, 95%CI: 2.9 - 6.6) were the predictor factors to compliance the FDRs for participation in colonoscopy screening program. Conclusions: Although in this study there was an association between lifestyle of FDRs and the compliance rate of colonoscopy screening test but according to the vulnerability of the relatives, more research in this field should be carried out.


Consider an analyst who models a strategic situation in terms of an incomplete information game and makes a prediction about players' behavior. The analyst's model approximately describes each player's hierarchies of beliefs over payoff-relevant states, but the true incomplete information game may have correlated duplicated belief hierarchies, and the analyst has no information about the correlation. Under these circumstances, a natural candidate for the analyst's prediction is the set of belief-invariant Bayes correlated equilibria (BIBCE) of the analyst's incomplete information game. We introduce the concept of robustness for BIBCE: a subset of BIBCE is robust if every nearby incomplete information game has a BIBCE that is close to some BIBCE in this set. Our main result provides a sufficient condition for robustness by introducing a generalized potential function of an incomplete information game. A generalized potential function is a function on the Cartesian product of the set of states and a covering of the action space which incorporates some information about players' preferences. It is associated with a belief-invariant correlating device such that a signal sent to a player is a subset of the player's actions, which can be interpreted as a vague prescription to choose some action from this subset. We show that, for every belief-invariant correlating device that maximizes the expected value of a generalized potential function, there exists a BIBCE in which every player chooses an action from a subset of actions prescribed by the device, and that the set of such BIBCE is robust, which can differ from the set of potential maximizing BNE.


Microelectrode geometry has significant influence on particles trapping techniques used on bioanalysis platforms. In this paper, the particle trapping patterns of dipole, quadrupole and octupole microelectrode using dielectrophoretic force (DEP) are discussed. The microelectrodes were constructed on a metal-insulator-metal platform, built on a silicon nitride (Si3N4) coated silicon substrate. The back contact is made from 20 nm nickel-chromium (NiCr) and 100 nm gold (Au) as the first layer. Then, SU-8-2005 (negative photoresist) is used on the second layer to create microcavities for trapping the particles. The third layer, where the three geometries were patterned, is made from 20 nm NiCr and 100 nm Au layers. Prior to fabrication, the particles trapping patterns of the microelectrodes were profiled using a finite element software, COMSOL 3.5a. Trapping patterns for the three geometries were evaluated using polystyrene latex microbeads. Results from the experiment validate simulation studies in term of microelectrode trapping ability up to single particle efficiency. It provides the potential of converting the trapping platform into a lab-on-chip system.


During the reaction catalyzed by the phosphofructokinase (EC 184.108.40.206) from Escherichia coli, the phosphoryl group transferred from ATP interacts with Thr-125 [Shirakihara, Y. & Evans, P. R. (1988) J. Mol. Biol. 204, 973-994]. The replacement of Thr-125 by serine changes the saturation by fructose 6-phosphate from cooperative to hyperbolic and abolishes the allosteric inhibition by phosphoenolpyruvate. The same changes, a saturation by fructose 6-phosphate that is no longer cooperative and an activity that is no longer inhibited by phosphoenolpyruvate, are observed with wild-type phosphofructokinase when adenosine 5'-[gamma-thio]triphosphate is used instead of ATP as the phosphoryl donor. These two perturbations of the ATP-Thr-125 interaction lead to the suppression of both the allosteric inhibition by phosphoenolpyruvate and the cooperativity of fructose-6-phosphate saturation, as if replacing the neutral oxygen of ATP by sulfur or removing the methyl group of Thr-125 had "locked" phosphofructokinase in its active conformation. The geometry of this ATP-Thr-125 interaction and/or the presence of the methyl group on the beta-carbon of Thr-125 are crucial for the regulatory properties of phosphofructokinase. This interaction could be a hydrogen bond between the neutral oxygen of the gamma-phosphate of ATP and the hydroxyl group of Thr-125.


The aim of this short communication is to briefly introduce the Camassa–Holm equations as a working model for simulation of incompressible fluid turbulence. In particular we discuss its application for turbulent boundary layer flows. This model (and related models) is studied for several years in mathematical community, starting from Leray [23]. It can be understood as a generalization of some classical fluid models (Navier-Stokes equations, Prandtl boundary layer equations), showing some interesting mathematical properties in the analysis of the behavior of it's solution (e.g. Layton and Lewandowski [22]). It has been found however, that the model predictions can lead to surprising extensions of the use of the model in technical applications, namely in simulating the turbulent fluid flows. This brief paper should be understood as an introductory note to this novel class of models for applied scientists. It gives the overview of the essential model formulations together with the relevant bibliographical summary.


Supply/Demand networks are undergoing rapid changes with the increasing use of dynamic rather than static information. This paper discusses the idea of intelligent products as both producers and consumers of dynamic information, before describing research in progress to develop a suitable simulation environment for experimenting with the intelligent product concept. The research will briefly consider the potential of a new Microsoft parallel programming environment (Axum) as a development tool.


PURPOSE Radiation-associated cardiac disease is a major cause of morbidity/mortality among childhood cancer survivors. Radiation dose-response relationships for cardiac substructures and cardiac diseases remain unestablished. METHODS Using the 25,481 5-year survivors of childhood cancer treated from 1970 to 1999 in the Childhood Cancer Survivor Study, we evaluated coronary artery disease (CAD), heart failure (HF), valvular disease (VD), and arrhythmia. We reconstructed radiation doses for each survivor to the coronary arteries, chambers, valves, and whole heart. Excess relative rate (ERR) models and piecewise exponential models evaluated dose-response relationships. RESULTS The cumulative incidence 35 years from diagnosis was 3.9% (95% CI, 3.4 to 4.3) for CAD, 3.8% (95% CI, 3.4 to 4.2) for HF, 1.2% (95% CI, 1.0 to 1.5) for VD, and 1.4% (95% CI, 1.1 to 1.6) for arrhythmia. A total of 12,288 survivors (48.2%) were exposed to radiotherapy. Quadratic ERR models improved fit compared with linear ERR models for the dose-response relationship between mean whole heart and CAD, HF, and arrhythmia, suggesting a potential threshold dose; however, such departure from linearity was not observed for most cardiac substructure end point dose-response relationships. Mean doses of 5-9.9 Gy to the whole heart did not increase the risk of any cardiac diseases. Mean doses of 5-9.9 Gy to the right coronary artery (rate ratio [RR], 2.6 [95% CI, 1.6 to 4.1]) and left ventricle (RR, 2.2 [95% CI, 1.3 to 3.7]) increased risk of CAD, and to the tricuspid valve (RR, 5.5 [95% CI, 2.0 to 15.1]) and right ventricle (RR, 8.4 [95% CI, 3.7 to 19.0]) increased risk of VD. CONCLUSION Among children with cancer, there may be no threshold dose below which radiation to the cardiac substructures does not increase the risk of cardiac diseases. This emphasizes their importance in modern treatment planning.


Dematerialization reduces national energy consumption, but it depends on many levels of industrialization and financial benefits. Dematerialization refers to a relative or relative reduction in the amount of material used to develop an economic production unit. In the tones of materials used per unit of GDP or the relative resolution of books, dematerialization has taken place in many countries for decades. These changes have been added to the structural exchange of energy-intensive sectors, in particular chemical and building materials.