Mitogen‐activated protein kinases (MAPK) are considered to play significant roles in colonic carcinogenesis and kinase inhibitor therapy has been proposed as a potential tool in the treatment of this disease. Reverse‐phase microarray assays using phospho‐specific antibodies can directly measure levels of phosphorylated protein isoforms. In the current study, samples from 35 cases of untreated colorectal cancer colectomies were laser capture‐microdissected to isolate epithelium and stroma from cancer as well as normal (i.e. uninvolved) mucosa. Lysates generated from these four tissue types were spotted onto reverse‐phase protein microarrays and probed with a panel of antibodies to ERK, p‐ERK, p38, p‐p38, p‐JNK, MEK and p‐MEK. Whereas total protein levels were unchanged, or slightly elevated (p38, p = 0.0025) in cancers, activated isoforms, including p‐ERK, p‐p38 and p‐JNK, were decreased two‐ to four‐fold in cancers compared with uninvolved mucosa (p < 0.0023 in all cases except for p‐JNK in epithelium, where decrement was non‐significant). This was backed up by western blotting. Dukes' stage B and C cancers displayed lower p‐ERK and p‐p38 expression than Dukes' stage A cancers, although this was not statistically significant. It is concluded that MAPK activity may be down‐regulated in colorectal cancer and that further exploration of inhibitory therapy in this system should be carefully evaluated if this finding is confirmed in larger series. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.


PURPOSE: To simplify a feeding device, and let it securely actuate by fixing a vertically long guide to an hammering tool, and providing a mouth piece guided to be slidable lengthwise in the vertically/long guide. CONSTITUTION: In a process of moving a mouth piece 4 against force of a spring 5, a screw 7 advances into a recess 4a in the mouth piece 5, and it is aligned with a screw driver 2 till the screw 7 reaches an screwing position. Next, a control pin 17 moves into a horizontal recessed part downwardly opened in an edge member 18, and the mouth piece 4 also moves backward against force of the spring 5 till a tip of the screw driver 2 reaches a head part 7a of the screw 7. As the mouth piece 4 further slides in this direction, a clutch between the screw driver 2 and a drive part of an hammering tool 1 is charged, and the screw driver 2 starts rotating. The screw driver 2 is engaged with a cross-groove at a screw head part 7a to let the screw 7 straight, and the screw 7 folds and returns a tab through a recessed part in a supply strip member 11 to move into the mouth piece 4 to be screwed.


The Internet or the web provides interesting and promising opportunities and features for people to meet and communicate in virtual environments. Today the Internet is not only for locating and for retrieving texts and documents, virtual communities on diverse topics emerge continuously to support communication between people and serve as meeting places. Chat rooms are often used to support this kind of meeting and communication. However, filtering large amounts of information from these chat rooms is not a trivial task and moreover being present in chat rooms at all times is utopia and quite impossible. This paper addresses a framework for a multiagent-supported community chat room. The agent framework supports users in identifying, retrieving, and filtering for them relevant and interesting information and conversations by monitoring the activity of one or more chat rooms. Users are able to communicate with their agent and delegate specific operations or tasks to the agent, e.g. monitor when certain users enter a room. Also, the solution supports that an agent is able to observe the actions of the user and recommend chat rooms or specific conversations in chat rooms based on its understanding of the user. The agent operates and makes decisions upon a number of profiles which are updated dynamically and which indicates the interests of the user. The agent is also able to communicate with other agents in order to make the most useful recommendations to its user. The framework includes an overall architecture of the involved agents and sketches for the interaction between the agents and the users.


This paper documents the transition of young people from high school to professional work, via tertiary study or vocational training and apprenticeships. In this paper, the authors identify various educational paths involving school and post-school study and assess the effectivness of these in relation to post-school outcomes at age 25 years. They use the 1995 cohort of the Longitudinal Surveys of Australian Youth and find that, for males, undertaking an apprenticeship after completing senior secondary and university are attractive paths. For females, the best path is that of university study, even for those with low academic orientation.


It is common to find causal statements in economics journals. In a recent article, for example, Babina et al. claim that "negative federal funding shocks reduce high-tech entrepreneurship and publications but increase patenting" (2023, 1). Unfortunately, t he actual meaning of 'cause' is not always explicitly spelled out. What does 'cause' mean in these statements? Do they connote the same meaning? More concretely, what do economists mean when they say X causes Y ? These questions motivate Mariusz Ma-ziarz's i ntriguing book on causality. Based on a previous systematic literature analysis


My research interests are in asymptotic results of expansions in finite groups, and how these expansion properties are tied to other properties of the groups. Given a finite group G and a generating set S, we can use S to denote the set {g ∈ G : g = s1s2...sk for s1, ..., sk ∈ S}. Then a natural question to inquire is how does the size of |S| grow as k grows, and how does this growth compare with |G|. In particular, we can define the following:


Propylene-based random copolymers with either ethylene or 1-hexene as comonomer, produced using a metallocene catalyst, were studied regarding their crystallization behaviors, with a focus on rapid cooling. To get an impression of processing effects, fast scanning chip calorimetry (FSC) was used in addition to the characterization of the mechanical performance. When comparing the comonomer type and the relation to commercial grades based on Ziegler–Natta-type catalysts, both an interaction with the catalyst-related regio-defects and a significant difference between ethylene and 1-hexene was observed. A soluble-type nucleating agent was found to modify the behavior, but to an increasingly lesser degree at high cooling rates.


A Gravity approach has been undertaken to investigate the determinants of China's agricultural imports from Sub-Saharan African (SSA) countries using panel data covering the period 1995-2014. China's agricultural import has increased significantly during the period and the agricultural export for the SSA countries is vital for their development. The empirical results show that the GDP of China, the GDP of the SSA country and the infrastructure, the institutional quality and the natural resource endowments within the SSA country and trade arrangements are significantly and positively impacting China's agricultural imports from SSA. The transportation cost is a weakening factor.


Hypoglycemia is a common acute complication in diabetes that is often treated with carbohydrate-rich snacks or drinks. For individuals with diabetes and household food insecurity (HFI), uncertain availability of food may increase fear of hypoglycemia (FOH). FOH may prevent individuals from optimal diabetes management. We analyzed data from 1,603 adult (≥18 years, mean 23.7 years, 80% type 1 diabetes [T1D], 20% type 2 diabetes [T2D]) and 592 youth (10.0-17.9 years, mean 15.2 years, 100% T1D) participants in the SEARCH for Diabetes in Youth Study. Adult participants and parents of youth participants completed the U.S. Household Food Security Survey, where ≥3 food insecure conditions or behaviors indicate HFI. Adults, youth, and parents of youth completed the Hypoglycemia Fear Survey that provides a behavior subscale (scores 0-60), worry subscale (scores 0-72), and total score (sum of subscales). We examined the association of HFI with FOH with general linear models, adjusting for socioeconomic, demographic, and clinical covariates. Approximately 20% of adults and 17% of youth had HFI. Adults with T1D reporting HFI (vs. no HFI) had increased FOH (+3 units for behavior, +11 units for worry, +14 units for total), after adjustment for covariates (all p This research suggests that among adults with diabetes and parents of youth with T1D, those with HFI are more likely to experience FOH than those without HFI. Implementation of common approaches to ameliorate risk of hypoglycemia such as carrying snacks is problematic for people who are food insecure. Providers could consider HFI when discussing hypoglycemia and fear thereof with their patients. Disclosure L.A. Reid: None. S. Zheng: None. J.A. Mendoza: None. B.A. Reboussin: None. K.A. Sauder: None. S. Saydah: None. J.M. Lawrence: None. E.T. Jensen: None. L. Henkin: None. K. Flory: None. L.M. Knight: None. C. Pihoker: None. L.M. Dolan: None. A.D. Liese: None. Funding National Institutes of Health (1UC4DK108173, 1R01DK117461-01)


Use the newest achievement of contemporary philosophy , aesthetics , theory of art, proceed from wide human culture vision , is it is it construct to solve to announce - is it it constructs to be basic law that art innovate to build , point out meaning its lie in, art that made under different culture background and different art forms have comparativity, contribute to exploring the method that art innovates, such as the key element changes France, graft France and wait.


Commercial Cyber-physical System (CPS) development tools (e.g. MathWorks' Simulink) are widely used to design, simulate and automatically generate artifacts which are deployed in safety-critical embedded hardware. CyFuzz, the state-of-the-art CPS tool chain testing scheme is inefficient, cannot generate feature-rich inputs and is ineffective in finding new tool chain bugs. To better understand various properties of publicly available CPS models, we conducted the first large-scale study of 391 publicly-available Simulink models. Next, we proposed an efficient CPS model-generation scheme capable of creating large, feature-rich random inputs. Our tool realization for testing Simulink which found 8 new confirmed bugs, along with the study-artifacts are publicly available.


Studies document how identity related processes, including identity centrality, shape mental well being. More research, however, is needed that considers how identity centrality impacts well being for people with more than one marginalized identity. Drawing from data from 1,571 black and Latinx sexual minorities included in the Social Justice Sexuality Project, I apply an intercategorical intersectional approach to examine the association between the intersection of sexual and racial/ethnic identity centrality and mental well being. Ordinary least squares regression models show three key findings. First, I found a significant association between both racial/ethnic and sexual identity centrality and mental well being. Second, my results highlight a significant interaction effect between sexual and racial/ethnic identity centrality, indicating the relationship between centrality and well being varies across different levels of centrality. Finally, my results indicate that after adjusting for identity centrality, other predictors remain significantly associated with well being.


Deterioration of an ecological situation, reduction of stocks of oil conducts to use of newer power sources – the fuel alternatives received from bioraw materials. The most probable substitutes of liquid fuels are bioalcohols, bioether and the biodiesel. In this article receiving dibutylether (DBE) from biobutanol on zeolites of structure of FAU, as a component of automobile or diesel fuels is considered. We studied the effect of temperature on the yield of DBE, and to compare the results obtained on sulphocationite KU-2FPP. Also identified the influence of the chemical composition of the zeolite Y on the basic parameters of the process compared to the sulphocationite KU-2FPP.


Nutrition and Management. Grasses used in dairy farm pastures in Central Thailand were Guinea (Penicum maximum), Ruzi (Brachiaria ruziziensis), Napier (Pennisetum parpureum), and Para (Brachiaria mutica). Some farmers planted mixtures of grasses and legumes to increase the nutritional value of pastures. Concentrate feed for cows was either produced by the farmers themselves, or purchased from dairy cooperatives and local companies. Feeding was based on concentrate (12 SUMMARY


The management of acute respiratory distress syndrome (ARDS) with non-invasive ventilation (NIV) is controversial. We report a case of a 69-year-old patient who developed ARDS after elective total hip replacement. During a 33-day stay in the intensive care unit (ICU) his respiratory failure was successfully managed with intermittent NIV through a transparent ventilation helmet, when he became intolerant of the facemask. Nearly four days were spent almost continuously in the NIV hood. The origin of the ARDS was never confirmed; possible causes included amiodarone toxicity, atypical pneumonia and fat embolus. The patient remained awake throughout, never exceeded single-organ failure, his respiratory function improved gradually and he was eventually discharged home.


This summary is based on a comprehensive health technology assessment available from CADTH's website (www.cadth.ca): Banerjee S, Brown A, Hutton B, McGahan L, Asakawa K, Clark M, Severn M, Cox JL, Sharma M. Clopidogrel versus Other Antiplatelet Agents in the Secondary Prevention of Vascular Events in Adults with Cerebrovascular Disease: Clinical and Cost-Effectiveness Analyses. [Technology report number 123].


The authors of the presented article consider the main changes in land legislation that occurred in 2020-2021 regarding the modernization of legislation on control and supervisory activities in the field of federal state land control (supervision). These changes require the study and attention of both public authorities and individuals and legal entities. The article analyzes the main provisions of the Federal Law of 11.06.2021 N 170-FZ "On Amending Certain Legislative Acts of the Russian Federation in Connection with the Adoption of the Federal Law "On State Control (supervision) and municipal control in the Russian Federation" regarding the implementation of state land control (supervision), as well as new documents adopted in its development. It is concluded that not only legislation changes, but also activities in the field of land control (supervision) as one of the main functions of land and other real estate management.


Accurate flood mapping is important for both planning activities during emergencies and as a support for the successive assessment of damaged areas. A valuable information source for such a procedure can be remote sensing synthetic aperture radar (SAR) imagery. However, flood scenarios are typical examples of complex situations in which different factors have to be considered to provide accurate and robust interpretation of the situation on the ground. For this reason, a data fusion approach of remote sensing data with ancillary information can be particularly useful. In this paper, a Bayesian network is proposed to integrate remotely sensed data, such as multitemporal SAR intensity images and interferometric-SAR coherence data, with geomorphic and other ground information. The methodology is tested on a case study regarding a flood that occurred in the Basilicata region (Italy) on December 2013, monitored using a time series of COSMO-SkyMed data. It is shown that the synergetic use of different information layers can help to detect more precisely the areas affected by the flood, reducing false alarms and missed identifications which may affect algorithms based on data from a single source. The produced flood maps are compared to data obtained independently from the analysis of optical images; the comparison indicates that the proposed methodology is able to reliably follow the temporal evolution of the phenomenon, assigning high probability to areas most likely to be flooded, in spite of their heterogeneous temporal SAR/InSAR signatures, reaching accuracies of up to 89%.


After the end of the crisis in the sector, the gap between the requirements of the real estate product and the reality of the sector was distant and mainly of a regulatory nature. The new requirements of the Technical Building Code (CTE) of multiple character and of recent approval then, contrasting with the standstill of the sector, had a delay in the application of the same ones in all the levels. The progressive response of the building sector has focused on the search for proposals and solutions that provide maximum reliability and performance to building investors and users, as well as the efficiency and safety of the building product. Housing is a relevant product in society, mainly private initiative, which affects economic growth and creates interference in many sectors.


cultural norms in southeastern Europe both among the German population and others living there. Interestingly, in 1938, the Nazis Kreigsmarine launched a heavy cruiser named Prinz Eugene. It survived the war but sank after the Americans employed it in a nuclear test in the Pacific Ocean in 1946. This name probably had little chance of attracting potential naval recruits from among the land-locked German populations of southeastern Europe. A similar historical reference utilized by the Nazis for recruitment among southeastern Europe's Germans was the 8th SS Calvary Division Florian Geyer. The name of this formation refereed to a revolutionary German military figure (1490–1525) used by the Nazis to recruit Germans from Transylvania and Banat. It also saw extensive anti-partisan service in Yugoslavia. Did the German communities of Romania and Yugoslavia tend to retain a strong historical self-awareness because they had lost a direct political connection to the Habsburg empire and through that the old Second Reich after WWI? Overall this is an excellent collection of studies of twentieth century German connections to southeastern Europe. Much interesting and useful information and interpretation is available here. One important concept that is emphasized by these articles is the prevalence of the Habsburg connection in northwestern southeastern Europe throughout the twentieth century. Austria and Germany's quick recognition of Slovene and Croatian independence from Yugoslavia in 1991 demonstrates this continuity. The editors never clearly delineate between Habsburg (Austrian) and German interests in southeastern Europe. Were they always the same even in the twentieth century? Nevertheless this collection provides a specific look at the importance of Germany to twentieth century general and regional European history.


In Christopher Healy's (2012) children's book, The hero's guide to saving your kingdom, the idea of hegemonic masculinity is subverted in various ways. In this reinvention of four fairy tales – 'Cinderella', 'Sleeping Beauty', 'Snow White' and 'Rapunzel' – the author seems consciously to subvert the prevalent stereotypes surrounding traditional representations of the idealised, yet largely uninterrogated image of 'Prince Charming'. All four of the princes who feature as protagonists in the book express their dissatisfaction at the prescriptive expectations that govern every aspect of their lived realities. Healy explores alternative ways of representing this type of character to modern child readers, in many cases testing the boundaries that dictate which physical characteristics and behavioural patterns are allowable in such characters. This article explores Healy's negotiation of masculinity in the context of its intended 21st century child audience


Abstract : The need to validate and improve numerical models of the MPD thruster flow, using detailed comparisons with experimentally determined plasma properties, is essential in the effort to improve MPD thruster efficiency. This research represents an attempt to experimentally identify trends, in the variation of plasma properties inside of a self-field MPD thruster, which could be meaningfully compared with numerical results. Experimental results, consistent with the numerical model in trend, show an axial variation of the electron temperature along the anode which exhibits a very distinctive double-peaked profile. Experimental axial profiles of the electron number density and current density were also consistent with the numerical model in trend. Such evidence, along with results of the numerical model, suggest that an oblique shock is present near the inlet, and is required to establish the radial pressure gradient so prevalent in the MPD thruster. This work marks one of the first non-trivial, successful comparisons between a numerical model and experimentally determined plasma properties inside the MPD thruster.


Part I: General principles. Introduction to hiring and leasing. Part II: Hiring without an operator and finance leasing. Hiring. Leasing. Contract hire and leasing with maintenance. Law relevant to all types of transaction involving bailments. Part III: Hiring with an operator and other hiring transaction governed by the Construction Plant-hire Association. Special characteristics of hiring with an operator. Part IV: Precedents. Part V: Appendices.


Abstract Psychopaths exhibit diminished ability to grieve. Here I address whether this inability can be explained by the trademark feature of psychopaths, namely, their diminished capacity for interpersonal empathy. I argue that this hypothesis turns out to be correct, but requires that we conceptualize empathy not merely as an ability to relate (emotionally and ethically) to other individuals but also as an ability to relate to past and present iterations of ourselves. This reconceptualization accords well with evidence regarding psychopaths' intense focus on the temporal present and difficulties in engaging in mental time travel, as well as with the essentially egocentric and identity-based nature of grief.


The results of a study showed the effect of some insecticides (Indoxacarb, Pymetrozine and Mythoxyfenozide) on stages plodia interpunctella (eggs, larvae, pupae and adults) Variation in the average mortality percentages the insect phases for the three insecticides as reached Indoxacarb insecticide 79.67, 50.00, 60.00 and 50.00% respectively as reached Pymetrozine insecticide 55.00, 50.00, 50.00 and 50.00% respectively and Mythoxyfenozide insecticide reached 70.66, 53.33, 40.00 and 60.00% respectively. The results From the results of the statistical analysis, it was found that Indoxacarb insecticide More effective in mortality the stages of the insect on average 59.92% then Mythoxyfenozide reached 56.00% and finally Pymetrozine insecticide reached 51.25%. The results showed that egg stage is more sensitive to the three insecticides than the other stages as reached 68.46, 51.11, 50.00 and 53.33% respectively. The results showed that the average mortality percentages were directly proportional to the increase in the concentrations of the three insecticides.


Giotto's Last Judgment in the Arena chapel in Padua, and particularly the scene of hell, has tended to be ignored in the considerable scholarly literature on the chapel. Yet, unusual emphases in Giotto's infernal imagery are revealing of contemporary attitudes to the clergy in early fourteenth-century Padua, as well as providing further evidence of the artist's acclaimed wit. The author examines the Paduan hell-scene in detail and relates its particulars to other visual and textual descriptions of the netherworld and to contemporary ideas of hell and the devil. Although the devil inspired fear he was also regarded as comic. The extravagant slapstick of Giotto's demons and the fact that his sinners seem not to exhibit signs of undue suffering might suggest that, in part, the Paduan inferno was meant to be humorous. Not only is there an unusually large number of clerics in Giotto's hell but several are punished by genital torture, suggesting that they have been guilty of sexual sins. Their unusual prominenc...


Transistors that use nanowires or nanotubes as the channel material have shown good performance as a result of their unique monocrystalline structure, with various advantages such as small cell dimensions and simplified lithographic processes for high-density device structures. [1–4] However, difficulties in aligning nanowires into desired positions and high-growth-temperature processes have slowed the development of the single-nanowire transistor. The concept of a nanowire-network transistor that uses many rather than single nanowires as the channel has shown a higher probability of realization. It can also be fabricated at low temperatures, opening up the possibility of using glass or plastic as the substrate. Although carbon nanotubes (CNTs) have been thoroughly investigated in network transistor applications, performance is limited by the fraction of metallic CNTs. This is seen in transistor operation as high off (leakage) current due to conduction through these metallic nanotubes. It is therefore preferable to remove the metallic CNTs before attempting to fabricate a CNT-based transistor. [5,6] Purely semiconducting nanowires, such as ZnO, can have an advantage in network transistors, as there are no metallic conduction paths to give rise to high off (leakage) currents. [7,8] To realize high-performance network transistors, 'wire–wire' point contacts and the alignment angle are parameters that have to be addressed. [9–12] However, the effect of the number of nanowire layers in the channel on performance network transistors has been overlooked. Here, we measure the changes in characteristics of mono-, bi-, and multiple-layer nanowire channel transistors and perform gate-field simulations to explain the results. Transistors were fabricated by precisely controlling the number of nanowires and


We demonstrate that an optically driven spin of a carrier in a quantum dot undergoes indirect dephasing via
conditional optically induced charge evolution even in the absence of any direct interaction between the spin
and its environment. A generic model for the indirect dephasing with a three-component system with spin,
charge, and reservoir is proposed. This indirect decoherence channel is studied for the optical spin manipulation
in a quantum dot with a microscopic description of the charge-phonon interaction taking into account its
non-Markovian nature.


The purpose of the undergraduate teaching assessment for common higher education institutions by the Ministry of Education is to give colleges and universities macro-control and guidance,with its final object of training all-round cultivated talents.A correct analysis and understanding of the teaching assessment is significant.This paper presents some suggestions on problems that higher education institutions should pay attention to in practice: curriculum enhancements,teaching quality,practical teaching and employment oppertunities.


Bearing characteristics and deformation mechanism of bridge piles under horizontal loads were analyzed using the failure mode.The calculation model of internal forces and displacement analysis in the layer foundation was established,and its solutions were obtained by power series method.The correctness of the calculation method was verified in a practical project.This work can provide a reference for the design and construction of similar projects.


The invention discloses a preparation method for a controlled release preparation which has improved drug releasing property and mechanical property and increased production repeatability and is externally coated with a controlled release coat film comprising drug released pores filled with air, especial for a zero-order release controlled release preparation. The preparation method comprises thefollowing steps of firstly preparing core material; secondly, coating a controlled release coat film for the core material with solution of polymer containing sublimable matters and/or matter particles capable of being degraded into harmless gases or a dispersion liquid; thirdly, subjecting the polymer coat film to healing processing until the coating core material has a stable dissolution characteristic endpoint; and fourthly, volatilizing and/or degrading the sublimable matters and/or the matters capable of being degraded into harmless gases, wherein the fourth step is finished after the third step.


Introduction: Left ventricular ejection fraction (LVEF) has long been the key parameter used to stratify the risk in patients after an acute myocardial infarction (AMI). Although patients evolving with a preserved LVEF seem to have a better prognosis opposed to those with a reduced LVEF, they may have a significant rate of cardiovascular (CV) events. We aimed to describe the prognosis and its risk factors in this often overlooked subgroup of patients. Methods: We studied patients referred to a cardiac rehabilitation (CR) program after an acute myocardial infarction (AMI) between January 2010 and December 2012. They had to have a LVEF >=50% at the time of hospital discharge (measured by transthoracic echocardiography) and completed CR program. The laboratorial data was collected from blood analysis measurement during hospitalization. The composite outcome was defined as all-cause death, heart failure hospitalization, de novo diagnosis or worsening HF at the outpatient clinic, and it was assessed by chart review. Results: The 235 studied patients had a mean age of 60±11 years and 80% were male. During a follow-up of 3.2±4.1 years, 31 (13%) had a composite outcome (19 de novo HF diagnosis, 6 HF hospitalizations and 6 deaths). Patients who had an event were older (68 years vs 59 years, P = 0.001), and had a higher prevalence of hypertension (81% vs 62%, P = 0.044) and diabetes (55% vs 28%, P = 0.003). There were fewer STEMIs in the group with an event (32% vs 41%, P = 0.001). They had higher Killip class during hospitalization (class II-IV: 28% vs 4.9%; P < 0.001) and more severe CAD (55% with three-vessel disease vs 30%, P = 0.06). Higher prevalence of chronic kidney disease (CKD) (26% vs 6%, P < 0.001) and anemia (45% vs 18%, P < 0.001) was also present in this subgroup. No significant difference regarding echocardiographic data was present between groups. N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) plasma levels during hospitalization were higher in the subset of patients that eventually had an event (median 408 [207-799] ng/mL vs 342 [124-569] ng/mL; P = 0.018). After adjusting for sex and age, only diabetes (HR-1.93; 95% CI: 1.12-4.24) and Killip class (HR-2.15; 95% CI: 1.15-4.02) remained significantly associated with incident outcome. NT-pro-BNP did not keep its significant prognostic value (HR-1.24; 95%CI: 0.88-1.76). Conclusions: These post-AMI patients did not have the benign prognosis that could be suggested by the preserved LVEF. Further studies are needed to examine the utility of diabetes, NT-pro-BNP plasma levels and new echocardiographic parameters to identify those at higher risk among this specific group of post-AMI patients. Key-words: Preserved left ventricle ejection fraction; post-acute myocardial infarction; natriuretic peptide.


In this paper, we firstly analyzed the Gordon and Mollenauer (G-M) effect in dual polarization quaternary phase shift keying (DP-QPSK) system, whose simulation results indicate that the G-M is the main impairment which should be given a careful consideration. Secondly, a self-correlation technique was used to extract the cross phase modulation (XPM)-induced phase noise and XPM-induced polarization scattering for analyzing the characteristics of XPM in coherent optical orthogonal frequency division multiplexing (CO-OFDM) wavelength division multiplexed (WDM) transmission systems. The phase noise is verified as the dominant distortion in DP-OFDM systems while the XPM-induced polarization crosstalk is proved to be the decisive distortion in DP-QPSK coherent experiment. Thirdly, we discovered that the statistical characterization of the nonlinear noise in densely spaced 16QAM OFDM system deviate from Gauss distribution in the absence of amplified spontaneous emission (ASE) noise that cannot be regarded as the same in QPSK system.


The Large Hadron Collider (LHC) project is an accelerator for protons and heavy ions, to be installed at CERN. The field distribution in the superconducting LHC main dipoles is dominated by the coil configuration and is very sensitive to the conductor position. Therefore modelling errors on the coil geometry have to be avoided using a method which does not require the meshing of the coil. For the 2-D calculation of iron induced field effects, the reduced vector potential formulation with node-based elements was recently applied. This paper deals with the extension of the method to three dimensions.


Background: Approximately 40% of AML patients with IDH1 mutation respond to monotherapy with the IDH1 inhibitor ivosidenib with a median duration of response of 8.2 months, suggesting that IDH1 inhibitors should be rationally combined with other agents to improve efficacy. We have previously shown the synergistic activity of the mutant IDH1 (mIDH1) inhibitor BAY1436032 with azacitidine. We have also shown that the leukemogenic activity of the mIDH1 protein depends on PHD3 independent of R-2HG and its inhibition as a novel therapeutic strategy (Chaturvedi et al. 2018). Inhibition of Brd4 has been shown to induce rapid differentiation and death of IDH2 mutated AML mouse models (Chen et al., 2013). In the present study, we assessed the combination of either conventional chemotherapy, prolyl hydroxylase (PHD) inhibitor molidustat or bromodomain inhibitor JQ1 with BAY1436032 (BAY) in a preclinical patient-derived xenograft (PDX) model of mIDH1 AML.
 Methods and Results: Leukemic cells from an AML patient with mutated IDH1, NPM1, FLT3-TKD and NRAS were xenografted in immunocompromised mice. We investigated the effects of BAY in sequential (seq) or simultaneous (sim) combination with cytarabine plus doxorubicin in our mIDH1 PDX model. The control groups were treated with either vehicle, BAY (150 mg/kg once daily p.o. continuously), or chemotherapy, which consisted of cytarabine (50 mg/kg once daily days 1-5 i.v.) and doxorubicin (1 mg/kg once daily days 1-3 i.v.). The treatment was repeated once after 29 days. The test groups were treated with BAY and chemotherapy in the doses mentioned above either starting both drugs on day 1 (sim group) or starting chemotherapy on day 1 and BAY on day 6 (seq group). Treatment with BAY was stopped after 12 weeks. Leukemic cells in peripheral blood constantly increased in vehicle and chemotherapy-treated mice with median time to 50% engraftment (MT 50%) of 84 and 112 days respectively. After stop of treatment, the percentage of leukemic cells increased in the group receiving BAY1436032 (MT 50%: 252 days) and sequential combination (MT 50%: 280 days), however, the MT50% was not reached with the simultaneous treatment (P<0.001). Median survival for vehicle-treated mice was 173 days, 206 days for chemotherapy-treated mice, 325 days for BAY treated mice, and 340 days for the sequential combination treatment. Strikingly, 5/8 mice treated simultaneously with BAY and chemotherapy survived until the end of the study at 400 days and the median survival was not reached.
 We hypothesized that combination therapy with BAY and molidustat may demonstrate superior anti-leukemic activity in comparison to single agents in the treatment of IDH1-mutant AML. mIDH1 PDX mice were treated with either vehicle, BAY at a dose of 150 mg/kg or molidustat at a dose of 10 mg/kg p.o. as monotherapy or in combination. The MT50% for Vehicle, Molidustat and BAY was 70, 70 and 182 days respectively,. However, the MT50% was significantly delayed (322 days) for the combination treatment (P<0.001). Interestingly, all mice treated with the combination had normal blood counts until week 40 and survived significantly longer than in the BAY group (median latency: 249 vs 179 days, P<0.001).
 Mutant IDH1 PDX mice were treated with either vehicle, BAY, BRD4 inhibitor JQ1 (50mg/kg i.p. once daily) or the combination of BAY and JQ1 for 12 weeks. JQ1 monotherapy showed a significant delay in leukemia engraftment compared to vehicle-treated mice in the first 12 weeks of treatment. During the treatment, the leukemic cells remained low in both BAY and combination treated mice but relapsed at the same time 4 weeks after the treatment had been stopped. Median survival for vehicle-treated mice was 139 days, 164 days for JQ1-treated mice, 220 days for BAY treated mice, and 242 days for the combination treatment (BAY vs combination; P=0.03).
 Conclusion: Similar to the combination treatment of BAY with azacitidine the concurrent administration of BAY with chemotherapy significantly improves efficacy of this combination compared to sequential administration. In addition, the combination of an IDH1 inhibitor with molidustat is a promising therapeutic approach, while the combination with the BRD4 inhibitor JQ1 did not improve the outcome compared to treatment with an IDH1 inhibitor alone. Our findings support ongoing and future clinical investigations and suggest that IDH1 inhibitors should be applied concurrently with chemotherapy.

 Chaturvedi: Bayer Pharma AG, Berlin, Germany: Research Funding. Kaulfuss:Bayer Pharma AG, Berlin, Germany: Employment. Panknin:Bayer Pharma AG, Berlin, Germany: Employment. Wagner:Bayer Pharma AG, Berlin, Germany: Employment, Equity Ownership. Jeffers:Bayer Pharma AG, Whippany, NJ, USA: Employment. Haegebarth:Bayer Pharma AG, Berlin, Germany: Employment, Equity Ownership. Heuser:Synimmune: Research Funding; Bayer Pharma AG, Berlin: Research Funding.


Isabelle of France: Capetian Sanctity and Franciscan Identity in the Thirteenth Century. By Sean L. Field. (Notre Dame, Indiana: University of Notre Dame Press. 2006. Pp. xii, 288. $35.00 paperback.) Isabelle of France (d. 1270), daughter of Louis VIII and Blanche of Castille, sister of Louis IX, devoted virgin of Christ, founder of the Franciscan female convent of Longchamp, pious, ascetic, and princess, was never formally canonized. This, despite the fact that she fit the ideal of pious royal women in the thirteenth century so often sainted (in a pattern of late medieval sanctification now clarified by Gabor Klaniczay), and despite an early and co-ordinated effort, including the writing of an important vita and the backing of her brother, the indomitable Charles of Anjou. Successful canonizations might founder on a myriad of institutional, political, or devotional rocks, but in this case must largely be attributed to Louis IX's own canonization in 1297, overshadowing his sister's fame and filling whatever appetite existed for a Capetian royal saint. In recent years, Sean L. Field has recovered Isabelle. First, in his edited edition of Agnes of Harcourt's Life of Isabelle of France, written in the 1280's (Sean L. Field, The Writings of Agnes of Har court: The Life of Isabelle of France and the Letter on Louis IX and Longchamp [Notre Dame, Indiana, 2003]), and now in his new biography of Isabelle herself (under review here), Field has explored Isabelle's career. As he indicates in his introduction (pp. 5-8), the life of Isabelle of France relates to three central themes in late medieval history-the power of women, sanctity and sanctification, and the development of female Franciscan spirituality and institutions. It is also a fascinating exploration of an extraordinary woman-from her rejection of the putative heir to the imperial throne (Conrad, son of Frederick II), to her commitment to lifelong virginity, to her deft negotiations with popes and kings, to her ability to quietly translate her moral authority as a consecrated virgin into political influence, to the veneration shown her after her death. Field argues that in the 1250's Isabelle was seen as a budding saint whose fame and renown was spreading beyond the court, who was recognized as such by contemporaries like Pope Alexander IV and Thomas of Cantimpre, and who was able to translate this reputation into effective power. The dual attributes of virginity and royalty were the defining features of Isabelle's identity for contemporaries. The book is structured chronologically.The first chapter examines Isabelle's childhood and negotiations for a political marriage. Her refusal to marry, and a subsequent illness, led to a vow of virginity which shaped her vocation and her life. …


admired and followed by many Polish biochemists. Thrice he served as the Rector of the Jagiellonian University in Kraków. He navigated the University through a difficult time of political transformation in Poland, modernized the ma-nagement system of the University and led to the commencement of the con-struction of the new University campus. He was the co-creator and the first Chair-man of the Conference of Rectors of Academic Schools in Poland. He will be remembered as a devoted community worker aiming at strengthening the bond between the Polish community abroad and our homeland, propagating know-ledge, promoting the concept of European integration, democracy and tolerance, as well as the collaboration between scientists, artists and men and women of culture. He was wise, righteous, and noble. Many had the honor of calling him their friend, and a great many saw in him a moral authority.


The Hazard Mapping System (HMS) was developed in 2001 by the National Oceanic and Atmospheric Administration's (NOAA) National Environmental Satellite and Data Information Service (NESDIS) as an interactive tool to identify fires and the smoke emissions they produce over North America in an operational environment. The system utilizes 2 geostationary and 5 polar orbiting environmental satellites. Automated fire detection algorithms are employed for each of the sensors. Analysts apply quality control procedures for the automated fire detections by eliminating those that are deemed to be false and adding hotspots that the algorithms have not detected via a thorough examination of the satellite imagery. Areas of smoke are outlined by the analyst using animated visible channel imagery. A quantitative assessment of the smoke concentration is not performed at this time. However, integration of automated aerosol and smoke products into the HMS, such as the GOES Aerosol and Smoke Product (GASP) and the MODIS aerosol product in early 2006 and the aerosol product from the Ozone Monitoring Instrument (OMI) later in 2006 are expected to aid in providing smoke concentrations and identifying areas of smoke. HMS analysts denote fires that are producing smoke emissions. These fire locations are used as input to the HYbrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model. In 2005 the model was upgraded to adjust emission rates based on the Blue Skies framework as opposed to using a constant emission rate. Future improvements include specification of fire duration and start/end time of emissions. It is expected that these enhancements will increase the accuracy of the total amount of emissions and their dispersion.


The binding of metals to curved carbon p-surfaces has attracted continuous scientific interest since the discovery of metal complexes of buckminsterfullerene C60. [1–3] Molecules that consist of fragments of C60, that is, buckybowls, open geodesic polyarenes, or p bowls, possess curved carbon psurfaces; examples include corannulene (C20H10) and sumanene (1, C21H12; Figure 1a). [4, 5] From a coordination chemistry


We implement a GMPLS-based control plane that solves the contention problem of Colourless and Directionless (CD) ROADMs. The method is simpler than implementing CD and Contentionless (CD&C) ROADMs and avoids the complex extension of OSPF-TE.


Electrically conductive epoxidized natural rubber filled with conductive carbon black was prepared. The AC conductivity (σAC), dielectric constant (ɛ′), loss factor (tan δ*) and dynamic mechanical properties of the composites were studied. It was found that the epoxide groups in epoxidized natural rubber molecules positively contributed to AC conductivity, dielectric constant, and tan δ* of the composites. Especially, the composite with epoxidized natural rubber containing 50% mol epoxide (epoxidized natural rubber–50) showed better electrical and dynamic mechanical properties than the composites with epoxidized natural rubber–25 or NR. The effects of conductive carbon black loading level on electrical conductivity and dielectric constant of the epoxidized natural rubber–50/conductive carbon black composites was also studied. The percolation threshold was found at very low content of conductive carbon black at volume fraction of 0.07 with the critical exponent value 2.04. Furthermore, the glass transition temperatures of epoxidized natural rubber–50/conductive carbon black composites were higher than those of epoxidized natural rubber–25/conductive carbon black or NR/conductive carbon black composites, and increased with conductive carbon black content.


This paper is the first one in a series of two papers presenting the main results obtained in a School Building, which are analyzed in view of the actual Indoor Air Quality (IAQ) Portuguese national regulation. Measurements were carried out in one building, ventilated by mechanical system to evaluate IAQ and thermal comfort parameters. Direct measurements were made with portable monitoring data loggers and in some longterm measurements. The students assessed through questionnaires the IEQ parameters felt in the classrooms a few moments before the end of the class. The IAQ and thermal comfort conditions in higher/university schools buildings has been found to be poor because of the high density of students in class rooms. In particular, the IAQ is a significant issue for these buildings in order to be healthy and comfortable for learning performance of students.


Abstract : The purpose of this inspection was to make an assessment of the general condition of the dam with respect to safety, based upon available data and visual inspection, in order to determine if the dam poses hazards to human life or property. The dam is in the small size classification, since it is greater than 25 ft high but less than 40 ft high, and the maximum storage capacity is greater than 50 ac-ft but less than 1,000 ac-ft. The inspection and evaluation indicates that the spillway does not meet the criteria set forth in the guidelines for a dam having the above size and hazard potential. The spillway will pass 32 percent of the Probable Maximum Flood without overtopping. The Probable Maximum Flood is defined as the flood discharge that may be expected from the most severe combination of critical meteorologic and hydrologic conditions that are reasonably possible in the region. The guidelines require that a dam of small size with a high downstream hazard potential pass 50 to 100 percent of the PMF. Considering the height of dam (26 feet) and the maximum storage capacity (250 acre-feet), 50 percent of the PMF has been determined to be the appropriate spillway design flood.


It is estimated that more than eighty percent of socioeconomic and business information has spatial or locational characteristics; the effective use of such spatial data can allocate resources rationally, reduce operational costs of business potentially, and regulate, monitor and improve regional business and economic environment usefully. On the other hand, GIS not only are powerful tools, methods and technologies about handling, analyzing, representing of geographic data, but also provide concepts, theories and methodologies on understanding of geographical world. Based on such understanding, this paper is attempting to introduce GIS to regional business and economic development. The relationships between regional business environment, place-marketing and GIS are discussed theoretically; and the potential applications of GIS-based place-marketing in regional development, especially in China's context, are also argued.


In this article, an on-chip self-calibrated 8- bit R-2R digital-to-analog converter (DAC) based on digi- tally compensated input offset of the operational amplifier (OPAMP) is presented. To improve the overall DAC perfor- mance, a digital offset cancellation method was used to com- pensate deviations in the input offset voltage of the OPAMP caused by process variations. The whole DAC as well as offset compensation circuitry were designed in a standard 90 nm CMOS process. The achieved results show that after the self-calibration process, the improvement of 48% in the value of DAC offset error is achieved.


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This booklet for an exhibition of five installations by Kennedy features minimal text beyond lists of the elements involved. One work features a list and illustration of pattern pieces required to make a traditional business suit; three others are represented by lists of commercially available housepaint colours sorted into categories which reference the seasons, the Middle East, and the Native. Another quotes titles of Hollywood westerns. Booklet text in German with artwork text in English.


From the Document: Chile, a country of 19 1 million people, is located along the Pacific coast of South America Chile traditionally has been one of the United States' closest partners in Latin America due to the countries' common commitments to democracy, human rights, and free trade Chile's transition to a higher level of economic development has enabled the country to play a more active role in foreign affairs, including U S - backed efforts to promote peace and stability in the Western Hemisphere International relations;Chile;Epidemics;COVID-19 (Disease)


Pulmonary arterial hypertension (PAH) is a chronic and rapidly progressive disease that is characterized by extensive narrowing of the pulmonary vasculature, leading to increases in pulmonary vascular resistance, subsequent right ventricular dysfunction, and eventual death. There are currently multiple approved drugs—developed as single or combination therapies in the last few years—that have improved outcome and functionality in PAH. However, despite improvement in short-term survival with these new effective therapies, PAH remains an incurable disease with a median survival of 7 years (Figure 1).1 This chronic disease state may be characterized by morbid events such as hospitalizations that herald rapid disease progression and account for a significant disease burden (Figure 2).2,3 Physician ability to predict PAH disease progression is critical for determining optimal care of patients. Accurate risk assessment allows clinicians to determine the patient's prognosis, identify treatment goals, and monitor...


Fault line selection device in small current grounding power system consist of data acquisition card(master) and fault line discriminator(slave).Master and slave devices were installed independently and communicate with each other through GPRS message module.Details about the principles as well as the hardware and software design of C8051F040 based data acquisition card were presented.The device's original signal connect mode was improved to make easy the circuitry connection,as a result,the numbers of bus lines and output lines were not limited.


Abstract Background Mucormycosis (MC) is a group of invasive fungal infections with a mortality rate approaching 100% in disseminated disease. The incidence of MC is low, with one study estimating 500 cases/year in the United States, making optimal treatment difficult to identify. Liposomal amphotericin B (L-ampho), along with aggressive surgical intervention, is the first-line treatment for MC. Isavuconazole (ISA) and posaconazole (POSA) are newer azoles used as salvage therapy in patients not improving with L-ampho. Limited data are available about the use of L-ampho in combination with ISA or POSA as an initial treatment regimen, but aggressive treatment empirically may increase favorable outcomes. Methods We performed a retrospective review of patients diagnosed with MC from 2013 to2017 at University Medical Center of Southern Nevada in Las Vegas, Nevada. Data collected included patient demographics, comorbidities, and predisposing risk factors as well as treatment regimens. Patients were evaluated for outcome after treatment therapy with monotherapy (L-ampho, POSA or ISA) or combination therapy (L-ampho with ISA). Results From 2013 to 2017, seven cases of MC were identified – five rhinocerebral (RC), one cutaneous (CT), and 1onepulmonary (PM). The most common risk factor was uncontrolled diabetes (5/7), followed by HIV (2/7) and non-Hodgkin lymphoma (1/7). Fifty-seven percent of patients received monotherapy and 43% received combination therapy (L-ampho/ISA). All the patients receiving combination therapy had RC. Seventy-one percent of patients survived to discharge regardless of treatment regimen. One hundred percent of combination therapy patients survived to discharge, whereas 50% of monotherapy patients survived to discharge. The two mortalities were patients with PM and CT MC. Conclusion MC is a rare infection with high mortality. For this reason, we are using ISA in combination with L-ampho as initial treatment to improve clinical outcomes. With our limited experience, combination therapy showed better rates of survival to discharge, without increasing adverse events. Our data suggest the use of combination therapy may improve outcomes in MC, but a larger sample of patients treated with initial combination therapy is required to strengthen conclusions about patient outcomes. Disclosures All authors: No reported disclosures.


ABSTRACT This is a commentary on Meyer, Sun, and Martin (2020), Synchronous, but not entrained: exogenous and endogenous cortical rhythms of speech and language processing.


Objective:To evaluate three-dimensional conformal radiotherapy(3-DCRT) and transcatheter arterial chemoembolization(TACE) combined with Aixiao Ruanganjian(AXRGJ) in treating primary herpatic carcinoma.Methods:One hundred and twenty four patients with primary herpatic carcinoma were randomly divided into 3-DCRT and TACE combining with AXRGJ group(n=41),3-DCRT combining with TACE group(n=44),and TACE alone group(n=39).The clinical effect,immunifunction and adverse reaction in the three groups were observed.Results:The total effective rate in 3-DCRT and TACE combining with AXRGJ group was 80.5%,3-DCRT combining with TACE group was 77.3%,while TACE group was 53.8%,respectively,comparison of the criteria the three groups show signicant difference(P0.05).The median survival time,6-month,12-month and 24-month survival rate in the 3-DCRT and TACE combining with AXRGJ group was 352 days,80.5%,43.9%,14.6%.The 3-DCRT combining with TACE group was 341 days,77.3%,40.9%,13.6%.The TACE group was 281 days,53.8%,28.2%,7.7%,respectively,comparison the three groups show signicant difference(P0.05).The improvent of immunifunction in the 3-DCRT and TACE combining with AXRGJ group was superior to other two groups (P0.05).The occurrence of adverse reations such as decreasing of leucocyte,platelet and hemoglobin,nausea and vomiting were obviously lower in the 3-DCRT and TACE combining with AXRGJ group than other two groups(P0.05).Conclusion:Three-DCRT and TACE combined with AXRGJ have affirmative clinical effect in treacting mid-advanced primary herpatic carcinoma with few adverse reactions which was to lerable to patients.


Based on the points raised below, we have made some improvements to the calculation of velocities and quality factors (sections 4.1 and 4.2). Moreover, we added a discussion to explain in detail the importance of this model for studies related to the physical properties of the firn and the characterization of subglacial materials using amplitude variations with offset (AVO) analysis. Furthermore, we have added a few paragraphs to the Introduction and to the Conclusions, to better explain the main purposes of our work and the possible new applications of the described methodology. 10


Sound penetration into large enclosures can be modeled approximately by ray methods. When these enclosures are elongated so as to admit simulation by a waveguide, the interplay between rays and guided modes becomes important. To clarify the relevant phenomenology, we examine the prototype problem of a rigid semi‐infinite baffled or unbaffled circular waveguide. Using the methodology of the geometrical theory of diffraction (GTD) and its modification to account for a guiding environment [L. B. Felsen and H. Y. Yee, J. Acoust. Soc. Am. 44, 1028–1039 (1968)], the interior field for arbitrary plane wave incidence is constructed by edge diffracted‐multiple reflected ray tracing, by modal expansion, and by physical optics (PO) applied to the aperture field. Stationary phase evaluation of the PO modal excitation coefficients establishes the connection with GTD, especially the mechanism of coupling from GTD into the modal fields. By reciprocity, the radiation problem can be handled in a similar way. Some conclusions are drawn for guides with noncircular cross section. [Work supported by ONR.]Sound penetration into large enclosures can be modeled approximately by ray methods. When these enclosures are elongated so as to admit simulation by a waveguide, the interplay between rays and guided modes becomes important. To clarify the relevant phenomenology, we examine the prototype problem of a rigid semi‐infinite baffled or unbaffled circular waveguide. Using the methodology of the geometrical theory of diffraction (GTD) and its modification to account for a guiding environment [L. B. Felsen and H. Y. Yee, J. Acoust. Soc. Am. 44, 1028–1039 (1968)], the interior field for arbitrary plane wave incidence is constructed by edge diffracted‐multiple reflected ray tracing, by modal expansion, and by physical optics (PO) applied to the aperture field. Stationary phase evaluation of the PO modal excitation coefficients establishes the connection with GTD, especially the mechanism of coupling from GTD into the modal fields. By reciprocity, the radiation problem can be handled in a similar way. Some conclusi...


Objectives: We investigated the effects of Clean-DM4 (C-DM4), a polyherbal extract consisting of Coptidis Rhizoma , Salviae Miltiorrhiza Radix , and Cinnamomi Cortex on high fat diet (HFD)-induced obesity and diabetes in mice. Methods: The C57BL/6 mice (6 weeks) were fed a HFD for 8 weeks and then adminis-trated with C-DM4 extract at 500 mg/kg (p.o.) once daily for 4 weeks. The changes of body weights, calorie intakes, and fasting blood glucose (FBG) levels were measured in mice. The serum levels of glucose, insulin, total cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in mice by enzyme-based assay. It was also observed the histological changes of pancreas, liver, and fat tissues with hematoxylin and eosin (H&E) staining. Results: The increase of calorie intakes and FBG levels in HFD-induced obesity mice was significantly decreased by oral administration of C-DM4 extract. C-DM4 extract administration was significantly reduced the increased levels of glucose, insulin, total cholesterol, AST, and ALT in obesity mice. In addition, C-DM4 extract inhibited lipid droplet ac-cumulation in liver tissues of obesity mice, hyperplasia of pancreatic islets, and enlarge-ment of adipocytes in adipose tissues. Conclusions: Our study indicates that C-DM4 extract could help improve obesity and to prevent diabetes progression.


Books reviewed:

Discussion-Based Online Teaching to Enhance Student Learning: Theory, Practice and Assessment. By Tisha Bender. Sterling, Virginia: Stylus Publishing, 2003. xviii + 206 pages. ISBN 1-57922-065-7. $24.95 (paperback).


Stock market is considered to be one of the most vital source for economic development in every country, but there are various factors that affect the performance of stock market directly or indirectly. The security prices reflect the performance of a company. Both economic and non-economic factors invariably affect stock return behavior. The behavior of stock market is an important determinant for investor's decision. This study aims to evaluate the impact of stock market behavior on Indian Infrastructure companies. For this purpose, data of top five Indian Infrastructure companies listed in BSE have been collected on the basis of highest market capitalization rate. For the said study, data have been collected for a period of 10 years from 2010-2019. Data so collected have been analyzed using Excel and EViews Software. The results of correlation depicted a very strong and positive correlation between Market Price Per Share (MPS) and Earning Per Share (EPS) and a very weak but positive relation with PriceEarning (P.E) Ratio. For the purpose of measuring the impact we have used panel data regression analysis. MPS has been used as the dependent variable and EPS, P.E Ratio and Dividend Yield have been used as the independent variables. As the Time period (T = 10 years) is greater than the cross-sectional unit (I = 5 companies), that is we have a long panel so Fixed Effects Model (FEM) should be appropriate but the results of Hausman test finalized Random Effects Model (REM) to be the best fitted model for the said study.


This essay explores the meaning of the phrase "high ... Misdemeanors" in the Constitution's Impeachment Clause. After a review of 18th century sources, it concludes that the phrase denotes breaches of fiduciary duties.


In a coastal area where the water depth changes rapidly, waves developed in the offshore propagate to the coast, with a massive energy without any dissipation. Particular attention should be paid to the occurrence of damage in an island, where the land is open towards the ocean, in the event of abnormal wind wave, and design of structures in such region requires thorough examination. The southern and northern coasts of Hongdo Island located in the western coast of South Korea face the ocean side, and are directly affected when a typhoon or a high wave occurs. Therefore, structural damage due to wave generation frequently occurred in the coasts, and repair and reinforcement work were carried out several times.


Historically, doctors have not entertained a broad enough view of the total human life cycle. While much attention has been focused on infancy, childhood, adolescence and adulthood as times of growth and change, we have all but ignored the later years and the often marvelous characteristics of "the survivors." The use of standardized methods for evaluating the mental and physical status of old people has deprived both practitioners and patients of the richness of life-long experiences. By taking the time to attentively listen to their patients' reflections of the past, physicians can help advance our growing understanding of human aging and expand the repertoire of mechanisms that are useful in clinical practice.


We performed interspecific hybridization in the haploid blade‐forming marine species (nori) of the genus Porphyra, which have a heteromorphic life cycle with a haploid gametophytic blade and a diploid microscopic sporophyte called the "conchocelis phase." The green mutant HGT‐6 of P. tenera var. tamatsuensis A. Miura was crossed with the wildtype HG‐1 of P. yezoensis f. narawaensis A. Miura; the F1 heterozygous conchocelis developed normally and released numerous conchospores. However, almost all the conchospore germlings did not survive past the four‐cell stage or thereabouts, and only a few germlings developed into gametophytic blades. These results indicate that hybrid breakdown occurred during the meiosis, while the surviving F1 gametophytic blades were considered a breakthrough in the interspecific hybridization of Porphyra. Organelle genomes (cpDNA and mtDNA) were found to be maternally inherited in the interspecific hybridization by molecular analyses of the organelle DNA. In particular, molecular analyses of nuclear DNA revealed that the surviving F1 blades were allodiploids in the haploid gametophytic phase; however, there is a possibility of the occurrence of rapid chromosomal locus elimination and rearrangement in the F1 conchocelis phase. Our findings are noteworthy to the breeding of cultivated Porphyra and will provide important information for understanding of the speciation of marine plants with high species diversity.


Interactions between wildlife and commercial harvest industries need to be understood to manage resources for all users. About 1.5 million eared grebes (Podiceps nigricollis), half the North American population, stage on Utah's Great Salt Lake (GSL) each fall. A $56 million commercial harvest industry also operates during fall when the harvest of brine shrimp (Artemia franciscana) cysts occurs. Eared grebes and commercial harvest both utilize brine shrimp cysts creating a potentially adverse relationship. We assessed the diet of eared grebes to determine the extent to which they are dependent on brine shrimp and their cysts. We collected individual birds to measure diets and examine changes in body condition of staging eared grebes. Cysts were consumed by 40% of collected eared grebes and made up >75% of aggregate biomass of stomach samples. Despite the high occurrence of cysts in stomach samples, cysts were not the primary food item of eared grebes. Cysts were held in the stomach for longer periods by feather mass, so esophagus samples were a better indicator of diet. Adult brine shrimp were the primary food collected from the esophagus from October until December. After cold water temperatures caused a die-off of adult brine shrimp, cysts became more prevalent in the diet of eared grebes. Concomitantly, eared grebe body weights decreased as their diet shifted to brine shrimp cysts. Current monitoring and management of commercial harvest are sufficient to maintain yearly populations of adult brine shrimp to sustain eared grebes populations. © 2013 The Wildlife Society.


The total infection rate of Taeina of the people around Erhai Lake was 9.3%.Infection rate of senior age group of Bai People was much higher,male residents,as well.The disease was mainly caused by eating raw pork.


This paper describes the recent progress in QMG bulks in Nippon Steel and Sumitomo Metal Corporation. QMG is a high-Jc bulk material, which consists of a single crystalline RE123 phase with finely dispersed RE211 particles. QMG bulks have a significant potential for high-field engineering applications, since they can trap high magnetic fields depending on their Jc and size. Gd-QMG bulks are very attractive for various bulk applications such as flywheel energy storage systems, ship motors, wind power generators, etc. The trapped magnetic field of Gd-QMG bulks 60 mm in diameter at 77 K is twice as large as that of Y-QMG bulks with a similar size due to their excellent Jc properties. An enlargement in the diameter of the bulk leads to the enhancement of the trapped magnetic field. The large Gd-based QMG bulks up to 150 mm in diameter were fabricated by incorporating the RE compositional gradient method. Compact nuclear magnetic resonance (NMR)/MRI spectrometers are one of the promising applications of bulk superconductors. Eu-QMG bulks are suitable for NMR magnets. NMR applications require extremely homogenous magnetic fields. In the Eu-system, the small paramagnetic moment of the Eu ion compared to the Gd ion improves the field homogeneity in the bulk.


This study was conducted to throw light on electromagnetic radiofrequency (EMR) emitted from cell phones which was accused of causing a number of negative health effects in the form of influencing on the heart and circulatory system. 110 adult albino rats, of both sexes, weighing 180- 200 gms were used in the present study. Animals were allocated into two main groups: group I, including rats exposed to cell phone EMF for 4 weeks; and group II, including rats exposed to EMF for 8 weeks. Each group was further subdivided into four subgroups, a control group and three subgroups exposed to EMF for either 1h/day, 2hrs/day or 3hrs/day, exposure being carried out six days/ week, at fixed time of the day. All rats were subjected to measurement of the systolic blood pressure on the day prior to the day of sacrifice, ECG recording, assessment of cardiac weights, absolute& relative, and MDA level in cardiac tissue, as well as determination of plasma renin activity, plasma total antioxidant capacity and plasma calcium level. Specimens from the apex of the heart were subjected to histopathological examinations. Obtained results revealed that systolic blood pressure was significantly increased in all EMF-exposed rats compared to their respective controls. The heart rate, deduced from the ECG tracings, was non-significantly altered in all groups exposed to EMF for 4 weeks and in the 8 weeks-1hr/day exposure group, but was significantly reduced in rats exposed to EMF for 2hrs or 3hrs/day for 8 weeks. The ECG recording of rats exposed to EMF for 4 weeks revealed a significantly higher R voltage in the group exposed for 3hrs/day, a significant increase in QRS duration in the groups exposed for 2hrs and 3hrs/day and significant prolongation of QT-c interval in the group exposed for 3hrs/day. On the other hand, the ECG recording of rats exposed to EMF for 8 weeks revealed significantly higher R and T voltages, and significantly prolonged P-R and QT-c intervals in the groups exposed for 2hrs or 3hrs/day, the QRS duration being significantly increased in all the 8 weeks- exposed groups. In addition, a significant increase in the absolute and relative weights of the whole heart and of the left ventricle in rats exposed to EMF 2hrs or 3hrs/day for either 4 or 8 weeks was obtained. Plasma renin activity was increased in all exposed rats, the increase being statistically significant in rats exposed to EMF 3hrs/day for 4 weeks, and in all the groups exposed to EMF for 8 weeks. Plasma calcium level was significantly decreased in all the exposed groups except for the group exposed for 1hr/day for 4 weeks. The plasma total anti-oxidant capacity was significantly decreased in all exposed groups, for either 4 or 8 weeks, while the MDA level in the cardiac tissue was only significantly elevated in the 8 weeks- 3hrs/day exposed group compared to the matched control group. The histopathological examination revealed hypertrophy, fragmentation and vacuolation of the myocardium, which were directly proportional to the exposure time. On conclusion, long-term exposure to cell phone EMF increases the liability for hypertension reflected on the ECG and cardiac weights which is accompanied by histopathological changes in the myocardium. In addition, an interaction of EMF with biological functions was achieved in the form of increased PRA, decreased plasma total antioxidant capacity and hypocalcemia.


With plenty of energy accessing to the distribution networks, traditional single direction power transmission of "source-grid-load" mode is changing. The wide-area measurement system light (WAMS Light) extends dynamic condition monitoring to the low-voltage grid. With the increasing scale of WAMS Light, the volume of high-precision, high-density data provided by phasor measurement unit (PMU Light) is increasing. Straight listing extensive synchronous data is difficult for dispatchers to extract useful information and learn the system status. This paper presents a compositive visualization method based on geographic information system (GIS) for real-time monitoring of synchronized data in distribution networks. In this paper, the primitive is designed to adequately consider the data characteristics of synchronous data applied in the distribution network. The frequency contour layer, the voltage phasor layer, and the non-electricity information layer are displayed and superimposed on GIS. The trend sparklines are presented according to the zoom level of the GIS, helping dispatchers effectively monitor the actual state and variation trend of each measurement just by one glace.


The present invention relates to a method of cutting a liquid crystal display panel. The method comprising: forming a first scribe line and a second scribe line on a surface of the first mother substrate and second mother substrates are bonded to each other in the facing first and second wheels, along the first scribe line a first and a second scribing the mother substrate and second mother substrates, a second round of a third scribe line is formed on the second mother substrate and second mother substrate along the third scribe line by cutting the second mother removing a dummy region on the substrate.


The article proposes a coevolutionary computational model "a herd of herbivores – a flock of predators". The selfish behavior of individuals of a herd of herbivores being attacked by a pack of predators is modeled. Attractive operators of patterns of individual and collective behavior of agents, as well as mechanisms of population selection, are considered. The results of a series of experiments with the model "herd of herbivores – a flock of predators" for the problems of finding a global minimum in known test functions are presented, as well as a nonparametric proof of the statistical significance of the results obtained using the Wilcoxon signed-rank test.


The influence of different parameters in the design of multi-blade fan , such as the ratio inner diameter of outer diameter, D1/D2 , number of blades, Z, inclination angle,α, outlet angle,βd2 , and inlet angle,βd1 , were examined in order to study relation between the flow pattern and noise level. In the present report, we investigated the fan performance and the noise characteristic experimentally and compared with simplified two-dimensional CFD analysis. The flow pattern passing the blades under the different geometrical conditions was examined and discussed in terms of fan performance and noise level. The results shows that high efficiency and low noise were attained in range of D1/D2=0.8-0.84 , Z=35-45 , α=30°-40°, and βd2=155°-165°. For these conditions, it was found that the pressure loss and noise generation in the flow between blades were attributed to the separation of the flow which was induced by the circulated vortex at the suction side, reattachment of the separated flow, and shear flow at the trailing edge. It was also confirmed that a large inner to outer diameter ratio gives a defected performance and big noise generation because of no reattachment of the separated flow. Also, the increasing of blade number resulted in the increasing of high frequency noise due to the vortices generation in shear layer in spite of rectification of passing flow.


A basic theory of an analytical calculation method to determine the atomic density of each individual nuclide contained in a homogeneous system of uranyl nitrate solution is presented. Atomic density or number density is a number of atoms or nuclides per cm3 or in a unit of atoms per barn-cm. This parameter is one of the important factors in defining the accuracy of neutronic calculations as such used in reactor core design. This work was carried out as part of neutronic design calculation of the SAMOP (subcritical assembly for 99Mo isotope production) project, where uranyl nitrate solution was used as fuel with uranium enrichment of 20%. A homogeneous solution made by dissolving uranyl nitrate salt [UO2 (NO3)2] into H2O solvent has been used as an approach to this model. Two kinds of solution were described i.e. one that was made based on the amount of UO2(NO3)2 dissolved in the solution and another one based on the amount of uranium in the solution. Expectedly this method can be used as an alternative way in estimating the atom density, solution density (g/cc) and the corresponding atom and weight fractions which is important in criticality calculations.


Taking traffic volume and speed collected by traffic detection system as input variables, this paper proposes three kinds of step-by-step variable speed limit control models to minimize estimated delay cost, crash cost and comprehensive cost, respectively. The freeway crash rate is estimated based on volume- over-capacity and speed deviation by the existing model, and then the comprehensive cost is computed in terms of estimated delay and crash rate. In tests that used field freeway from about 20km segment of Qing- lan freeway with eight variable speed limit signs, these developed three controls show promise in reducing the numbers of vehicle stops, stopped delay and equivalent travel delay based on micro simulation results, smoothing traffic speed and improving traffic safety. Nevertheless, travel time of freeway vehicles is increased a little. Additionally, sensitivity analysis of driver compliance rate indicates that benefits of variable speed limit are gradually reduced as compliance rate decreased. When the compliance rate is below 80%, benefits are significantly decreased; and benefits are essentially unchanged if it is less than a threshold of 60%.


In the paper,the continuous annuities under the controlled random interest rates are investigated.The expectation of the present value of continuous annuities is derived under the controlled conditions.


Recent work in the study of multiple networks have given new insights into the dynamics of competition between complex systems and the importance of individual nodes in each sub-network. In order to study the importance of a National Innovation System in the global economy, we represent the global patent citation network as a multiplexed network of individual national economies and model the technological spillovers due to innovation originating in a specific national economy as a random walk between patent classes.


Parallel development in branches is a common software practice. However, past work has found that integration of changes across branches is not easy, and often leads to failures. Thus far, there has been little work to recommend developers who have the right expertise to perform a branch integration. We propose TIPMerge, a novel tool that recommends developers who are best suited to perform merges, by taking into consideration developers' past experience in the project, their changes in the branches, and de-pendencies among modified files in the branches. We evaluated TIPMerge on 28 projects, which included up to 15,584 merges with at least two developers, and potentially conflicting changes. On average, 85% of the top-3 recommendations by TIPMerge correctly included the developer who performed the merge. Best (accuracy) results of recommendations were at 98%. Our inter-views with developers of two projects reveal that in cases where the TIPMerge recommendation did not match the actual merge developer, the recommended developer had the expertise to per-form the merge, or was involved in a collaborative merge session.


This paper presents a coupled analysis method for a linear oscillatory actuator that can convert the rotation into linear motion using DC motor and magnetic conversion mechanism. In this method, motion equations of motor rotation and linear motion are simultaneously solved employing the 3-D finite element method. The usefulness of the method is verified to confirm the mutual influences of motion on dynamic characteristics


During ethanol production, yeasts are subjected to a number of stress factors - among them high substrate concentrations and high temperatures - while displaying an ability to adapt to the adverse conditions found during fermentation. This study evaluated the metabolic profile exhibited by Saccharomyces cerevisiae Catanduva-1 during fermentation. Yeast cells were cultured in 2% YPD medium, incubated in a shaker at 30 °C and 250 rpm for 10 h, and subsequently centrifuged and washed in saline solution for biomass harvesting. Fermentation experiments were performed at 18, 22, and 25°Bx sterilized at 120 °C for 20 min. Biomass was reinoculated into wort and incubated in a shaker at 30 °C and 40 °C at 250 rpm. Evaluation of fermentation parameters revealed better fermentative performance at 30 °C for all substrate concentrations investigated. Under the test conditions, cellular stress was observed at 40 °C. A superior ethanol production profile was obtained at 22°Bx and 30 °C. Glycerol accumulation was highest at 25°Bx and 40 °C. DOI: http://dx.doi.org/10.17807/orbital.v10i1.1029


In order to further study the tensile properties of the polyester yarn,the yarn was processed by styrene-butadine-styrene(SBS)and polyurethane(PU).Tensile properties were tested and the results were analyzed.The experimental results indicated that there were close relations between tensile properties and the kind of resin finishing liquor and the mass fraction.The breaking strength,breaking elongation ratio and the rupture work of the yarn increased with the increasing mass fraction at first.To a certain extent,these properties began to decrease.The breaking tenacity of the yarns finished by PU decreased more compared with the SBS finishing.In terms of increasing breaking strength,breaking elongation ratio and the rupture work,PU finishing was better than SBS finishing.While the specific breaking work of the yarn finished by SBS was better.


The sequence similarity within the amino‐terminal regions of parathyroid hormone (PTH) and PTH‐related protein (PTHrP) allows the two to share actions at a common site, the PTH1 receptor. A number of biological activities have been ascribed to actions of other domains within PTHrP. PTHrP production by late stage breast cancer has been shown to contribute to bone metastasis formation through promotion of osteoclast formation and bone resorption by action through PTH1 receptors. There is evidence also for a role for PTHrP early in breast cancer that is protective against tumour progression. No signalling pathway has been identified for this effect. PTHrP has also been identified as a factor promoting the emergence of breast cancer cells from dormancy in bone. In that case, PTHrP does not function through activation of PTH1 receptors, despite having very substantial effects on transcriptional activity of the breast cancer cells. This indicates actions of PTHrP that are non‐canonical, that is, mediated through domains other than the amino‐terminal. It is concluded that PTHrP has several distinct paracrine, autocrine, and intracrine actions in the course of breast cancer pathophysiology. Some are mediated through action at PTH1 receptors and others are controlled by other domains within PTHrP.


The paper is devoted to the analysis of humidity migration and heat transfer processes in walls made from a new generation of autoclaved aerated concrete blocks. The paper gives experimental results of humidity migration and heat transfer processes in a new generation of autoclaved aerated concrete walls as well as measurements of climatic data during the experiment. Analyzing experimental data, the model for climatic data evaluation in the Baltic Sea states was created and tested. The influence of a new generation of autoclaved aerated concrete wall finishing materials on the drying process of the wall was also studied in this paper.


The genus Cladosporium is cosmopolitan in distribution and can be isolated from various sources including plants as endophytes. A strain of Cladosporium was isolated from living leaves of Zygophyllum coccineum in a desert habitat in Oman. Phylogenetic analysis based on the combined internal transcribed spacer (ITS), partial translation elongation factor 1-alpha (TEF) and partial actin (ACT) sequence data shows that this is a novel species, which groups with Cladosporium sphaerospermum complex. The new species is introduced as Cladosporium omanense and is described, illustrated and compared with other known species in the genus. Cladosporium omanense differs from its phylogenetically related species C. endophyticum by its fast growing colonies, longer macronematous and micronematous conidiophores, thickened-walled conidia with conspicuously protuberant shrivelling surface ornamentations.


Based on the principles of scenery ecology in tourism development, the paper analy- ses the basic conditions for developing ecological tourism in the Shimian Mountain. In the course of macroscopic application of scenery ecology in the tourism development, the Shimain Mountain is divided into 14 scenic spots and 10 functional regions, thus leading to the overall planning of the ecological tourism in the Shimian Mountain.


We used bi-axial VSM to evaluate the anisotropy dispersion of a rotational-field-annealed CoZrNb thin film that shows an almost isotropic M-H curve. It was demonstrated that the isotropic properties of this film resulted from wideangle dispersion of the anisotropy. Using the measured Hk of the film, we calculated the frequency dependence of the permeability, and found that the calculated value agrees well with the measured one. We also calculated the magnetic torque curve, using the measured magnetic anisotropy dispersion of a CuMo-permalloy film. The calculated curve also agrees well with the measured curve.


To examine the association between mental illness and chronic physical conditions in older adults and investigate whether co‐occurring substance use disorders (SUDs) are associated with greater risk of chronic physical conditions beyond mental illness alone.


An increase in the incidence of forest pathogens in the Western US has created new resource management issues. In this research I employ a dataset of 170,141 housing transactions in twelve Western Washington counties to quantify the impacts of parasitic forest damage on the proxy real estate market. Specifically, I estimate a set of hedonic fixed effects models to control for omitted variable bias and spatial autocorrelation. Results show statistically significant impacts on property values in the presence of species specific and aggregate defoliation, suggesting new information for forestry management and policy.


Plot of the analysed concentration (black diamonds – left axis) and the bias (open triangles – right axis) expressed as wt% for fluorite using the internal standard method with zincite designated as the internal standard. The analysis was calibrated using sample 1H where the fluorite and zincite concentrations are 34.69 and 30.19 wt%, respectively.


Over a decade the charging of locally available electric vehicles like easy-bikes and motorized rickshaws have been imposing a significant amount of load on the national grid of Bangladesh. Because of the large number of these electric vehicles being charged at specific hours of the day, their charging load has brought about a great concern for the power distribution system. In this paper, a statistical analysis has been performed to study the effect of charging electric vehicles on the daily load curve. In doing so, the daily load curve of 2005 was mapped to the load curve of 2018 and was compared to observe the effect, considering different percentages of electric vehicles connected to the grid for charging. Also, peak generation and respective hours for the last eleven years were also analyzed to spot the shift in the peak generation time during peak hours.


An open-graded friction course (OGFC) is an asphalt mixture designed with a large air void (AV) content that provides enhanced drainage capability at the surface. The main objectives of this study were to investigate the impacts of selected factors (i.e., the OGFC thickness and coefficient of permeability, the permeability of the underlying layer, and traffic loading) on the drainage characteristics of the OGFC, develop a quantitative tool to simulate the deterioration in the functional performance of the OGFC, and propose new guidelines for the AV content of OGFC for optimum functionality. To this end, a three-dimensional finite element (FE) model was developed to evaluate the impacts of OGFC permeability, OGFC layer thickness, underlying layer permeability, rain intensity, and traffic volume on the seepage characteristics of OGFC pavements. The impacts of these factors were evaluated by calculating the time at which the OGFC surface reaches overflow condition ( TC). Statistical analysis of the results showed that all considered factors had a significant impact on OGFC seepage characteristics, except OGFC permeability. In addition, an artificial neural network (ANN) model was developed to predict TC without the need for FE modeling. Results indicated that the ANN model predicted TC accurately with R2 values of 0.99 and 0.98 in the training and validation stages, respectively. The results also indicated that the model accurately predicted TC over time for OGFC pavements with a root-mean-square error of less than 5.0%. Simulation runs were conducted using the developed FE model under different OGFC AV content conditions and rain intensities. Results revealed that an OGFC layer with an AV content of 16% would provide adequate drainage performance while minimizing OGFC durability issues.


The preparation of pits bottom was studied by orthogonal tests and the best programs for pits bottom preparation was summed up as follows:pits bottom fermented grains(one steamer volume) grinded by grains beater,then the addition of 120 kg starter and tailing liquor(15 %vol) 240 kg and 15~20 kg auxilliary materials and golden yellow pits bottom water,pit entry operated after even mix of all the materials,then through the culture for 2~3 production turns,and the pits was finally capable of liquor roasting until the occurrence of pits bottom fermented grains flavor which was helpful for the improvement of the quality of pits bottom liquor and could ensure high yield of second-grade pits.


Task allocation is a typical problem in the area of high performance computing and has been extensively studied in the past. However, existing algorithms cannot be directly used in WSN (wireless sensor network) due to severe energy constraint. A nested optimization technique based on genetic algorithm is proposed for energy-efficient task allocation in multi-hop clusters. The general optimization object can meet application's real-time requirement while realizing energy efficiency. Optimal solution can be achieved by incorporating GA-based task mapping, GA-based routing, communication scheduling and dynamic voltage scaling (DVS). Performance is evaluated through simulations with randomly generated task graphs and simulation results show better solution in terms of real-time and energy-efficiency compared with random optimization techniques.


Iamblichus, Protrepticus, chapter X (54, 10-56,12, edit. H. Pistelli, 1888), which is commonly regarded as a fragment or "cluster of excerpts" from Aristotle's Protrepticus, contains the following lengthy statement : "From a close study of the arts and crafts it can readily be ascertained that theoretic (philosophic) wisdom (φρονήσις) is of the greatest (practical) use in managing our lives (54, 10-12). Just as the most skilled among the members of the medical profession and the majority of those who are experts in physical training agree that people who intend to be good physicians and good coaches (gymnasts) must have a general acquaintance with nature (φύσις), so, too, must good lawgivers have an encompassing knowledge and understanding of nature and, as a matter of fact, an even better knowledge and understanding of nature than physicians and gymnasts (54, 12-18). For the former use their skills exclusively for the well-being and strength of the human body, while the latter, being concerned not only with the well-being and virtues of the soul, but also with determining the salvation or perdition of the whole commonweal, need philosophy and philosophic knowledge to an even higher degree (54, 18-22). Now, in the general and ordinary (mechanical) crafts and craftsmanlike operations, the most efficient tools or measures are derived directly from nature for instance, the carpenter's ruler, the rod or compass in the housebuilder's trade the more so, since some of our tools were suggested by observing the behavior of water, others by observing the behavior of light and of the sun's rays. And it is through our reliance on these tools or measures that we determine what, according to our senses, is sufficiently straight and smooth (54, 22-55, 1). Similarly, the statesman must derive from nature as well as from objective reality itself some definite standards with reference to which he determines what is just, what is good (honorable), and what is expedient (advantageous 55, 1-55, 3). For just as in the general and ordinary crafts the above-mentioned tools are superior to all other tools, so, too, the most excellent standards (laws) or basic norms are those which are in the greatest possible conformity with nature or objective reality (55, 4-6). But no one who has not practiced philosophy and is not capable of practicing philosophy, and who


We investigated the preservation of non-local correlations between polarization-entangled photons when one of them traveled through brain tissue slices of different thicknesses. Using down-converted photons at a wavelength of 802 nm minimized the absorption by the tissue. After the light passed through the tissue samples, we performed quantum state tomography to obtain quantitative measures of the entanglement. We found that entanglement is preserved to a surprising degree, and when it degrades, it does so following a particular path in a tangle versus linear-entropy graph. Such a trajectory reveals direct transfer of probability from entangled to mixed state.


Brownian motion and thermophoresis diffusions are the fundamental ideas of abnormal upgrading in thermal conductivity via binary fluids (base fluid along with nanoparticles). The influence of Brownian motion and thermophoresis are focused on in the Buongiorno model. In this problem, we considered the Buongiorno model with Brownian motion and thermophoretic effects. The nonlinear ordinary differential equations are recovered from the partial differential equations of the boundary flow via compatible similarity transformations and then employed to the Keller-box scheme for numerical results. The physical quantities of our concern including skin friction, Nusselt number, and Sherwood number along with velocity, temperature and concentration profile against involved effects are demonstrated. The impacts of the involved flow parameters are drawn in graphs and tabulated forms. The inclination effect shows an inverse relation with the velocity field. Moreover, the velocity profile increases with the growth of the buoyancy effect.


A computer-assisted mining machine requires subsystems for machine intelligence, navigation positioning, and computer control. One subsystem, an onboard, multisensor, computer-based heading system that would be responsible for determining and controlling machine heading is described. A directional gyroscope provides heading (yaw), fluxgate sensors provide compass data, and gravity-referenced clinometers give machine pitch and roll information. The system utilizes a dedicated microcontroller networked to an external system of computers. Tram commands, which are supplied to the network from external computers, are executed by the onboard system. Sensor feedback is employed for closed-loop control of machine heading by controlling pivots and turns. The operating limitations and error sources of the system are presented, along with implementation of closed-loop control of machine yaw. Results from mine machine tests are used to exhibit the various sensor shortcomings and evaluate heading control during tests of machine pivots and turns. >


This paper introduces the United Nations Sustainable Development Goals (SDGs) with the use of tablet and online tools in a project-based learning format. This research was specifically designed for Japanese junior high school learners and targeted towards teachers of young English as a foreign language (EFL) learners who may be interested in incorporating technology, project-based learning (PBL), and real-world content into the language learning experience. This project addresses challenges and impactful topics within a junior high school EFL class employing the content and language-integrated learning (CLIL) methodology and incorporates subjects, such as social studies, geography, intercultural studies, and environmental literacy. We have attempted to illustrate the individual steps and outcomes of this project and demonstrate that this project can not only improve English skills but also become a meaningful learning experience that draws on knowledge of other school subjects.

本稿では、タブレット端末とオンラインツールを用いて、国連の持続可能な開発目標(SDGs)をプロジェクトベースの学習形式を用いて紹介する。特に日本の中学生を対象とし、テクノロジー、プロジェクト学習、実社会のコンテンツを言語学習に取り入れることに関心のある若い外国語としての英語学習者(EFL)の教師をターゲットにしている。当該プロジェクトは、中学校のEFLクラスにおいて、社会科、地理、異文化研究、環境リテラシーなどの教科を取り入れ、内容言語統合型学習(CLIL)の方法論を採用し、課題やインパクトのあるトピックを取り上げている。本稿は、当該プロジェクトの個々のステップと成果を説明し、プロジェクトが英語力を向上させるだけでなく、他教科の知識を取り入れた有意義な学習体験となることを実証する。


Molecular bio-imaging based on optical detection is facing important challenges in the attempt to develop new materials and small molecules able to have better emission quantum yield, stability toward photobleaching and long excited-state lifetime. A strategy to achieve these properties is to use triplet emitters based on metal complexes and to protect them from dioxygen quenching. We report on an interesting approach based on the use of self-assembled platinum compounds in order to obtain stable, highly emissive and long-lived species. Cell internalization and localization experiments show that the assemblies possess a different selectivity towards cellular compartments dictated by the terdentate ligand coordinated to the platinum. Also, the conditions used for the incubation determine cell internalization of the platinum complexes or their expulsion in the media.