━━ Background. Previous reports on limbic encephalitis as a paraneoplastic syndrome have indicated that in many cases the neurological symptoms do not improve even if the tumor shrinks. We report a case of limbic encephalitis due to small cell lung cancer in which the patient was rescued and his Performance Status (PS) was significantly improved by the performance of antitumor therapy with artificial respiration. Case. A 60-yearold man was transported to our hospital by ambulance due to convulsions. He had repeated spasms and was unable to communicate or walk. Based on the results of our examination, the patient was diagnosed with small cell lung cancer stage IIIB. Head MRI (FLAIR) showed a high signal intensity in the hippocampus and limbic system, and was diagnosed with paraneoplastic limbic encephalitis (PLE). CBDCA+VP-16 was initiated. On the fourth day of treatment he became convulsive, and artificial respiration was initiated to stop his convulsions. He was extubated on the 12th day after the disappearance of spasm and shrinkage of the tumor. No further attacks occurred. A test for anti-Hu antibodies was negative. Head MRI showed improvement of the high signal intensity of the limbic system. Thus, we continued chemotherapy. Thereafter, his consciousness and communication improved, and he was discharged alone, and subsequently returned to work. Conclusion. Although paraneoplastic neurologic symptoms do not generally improve, it is reported that therapeutic effects may be expected for neurological symptoms in patients who are negative for anti-Hu antibodies. Since small cell lung cancer is a tumor with a high temporary treatment response rate, we considered that an antitumor effect could be expected in a patient with a poor performance status before treatment. In this case, treatment could not be delayed until the result of the anti-Hu antibody test were available, and antitumor treatment was provided with artificial respiration control. As a result, we were able to rescue the patient because his neurological symptoms of paraneoplastic limbic encephalitis improved along with the antitumor effect. We believe that among patients with paraneoplastic limbic encephalitis who are anti-Hu antibody-negative and who have a tumor with a high treatment response rate, even cases with a poor PS may be rescued by antitumor therapy. (JJLC. 2019;59:408-412) KEY WORDS━━ Paraneoplastic syndrome, Small cell lung cancer, Antitumor therapy, Paraneoplastic limbic encephalitis, Seizure Corresponding author: Ryoko Inaba Higashiyama. Received March 21, 2019; accepted June 11, 2019. 要旨━━背景.傍腫瘍性神経症状は改善困難の報告が 多い.積極的な抗腫瘍療法で救命し得た肺小細胞癌によ 1国立がん研究センター中央病院呼吸器内科;2大垣市民病院呼 吸器内科. 論文責任者:東山量子. 受付日:2019年 3月 21日,採択日:2019年 6月 11日. (肺癌.2019;59:408-412) 2019 The Japan Lung Cancer Society Paraneoplastic Limbic Encephalitis of SCLC Recovered by Treatment―Higashiyama et al Japanese Journal of Lung Cancer―Vol 59, No 4, Aug 20, 2019―www.haigan.gr.jp 409 Figure 1. A chest radiograph showing right hilar lymphadenitis. Figure 2. Chest CT showing a right lower lobe nodule, with hilar lymphadenopathy. る辺縁系脳炎を経験したので,報告する.症例.60歳男 性.痙攣を繰り返し,疎通・歩行が不能となった.精査 で肺小細胞癌 IIIB期,頭部MRIで辺縁系に高信号を認 め,辺縁系脳炎と診断した.CBDCA+VP-16を開始し た.Day 4痙攣が重責し,止めるため人工呼吸管理とし た.Day 12痙攣消失と腫瘍縮小を確認し,抜管した.以 後痙攣はなかった.抗 Hu抗体は陰性と判明した.MRI で辺縁系高信号の改善を認め,化学療法継続とした.徐々 に意識状態が改善し,独歩退院し就労復帰した.結論. 一般に傍腫瘍性の神経症状は改善が乏しいが,抗 Hu抗 体が陰性の場合神経症状に対し治療効果が見込める可能 性が指摘されている.肺小細胞癌は治療奏効率が高い腫 瘍であり,PS不良でも治療で改善が期待できると考え た.本症例は抗 Hu抗体の結果確認を待てない状況であ り,人工呼吸管理して化学療法を継続した.結果,神経 症状の改善が得られ救命できたと考える.治療奏効率が 高い腫瘍による抗 Hu抗体陰性の傍腫瘍性辺縁系脳炎で は,PS不良例でも積極的な抗腫瘍療法で救命の可能性が ある. 索引用語━━傍腫瘍症候群,肺小細胞癌,抗腫瘍療法, 傍腫瘍性辺縁系脳炎,痙攣


Results were presented on the power consumption by agitation accompanied by aeration. Analysis of the power led to the introduction of dimensionless term NA and it was found possible to correlate the power consumption withNA.(1)Principal data were obtained with the impellers shown in Fig. 4. Tanks used were respectively of diameters 27.4cm, 20 and 16.5cm. The air inlet nozzles were settled beneath the center of agitation (Fig. 2). The following are the relative dimensions held throughout the experiments.Results are summarized as follows;1) With the paddle, the relation (1) holds good as was illustrated in Fig. 5. (Pg/P0) first decreases with the increase of NA and then it shows a tendency to have a definite value with NA which is larger than 4×10-2.2) With a vaned disk, there exist the limiting rotational speeds nc which are the function of Di.The relation (1) holds fairly good with the rotational speeds, larger than nc.The number of blades has remarkably important effects on power consumptions, which was shown Fig. 8.3) With the turbine, the relation (1) holds good with engineering estimation as was illustrated in Fig. 11.4) The position and diameters of air inlet nozzles have little effects on power characteristics.


This paper presents a dynamic model, inspired by evolutionary game theory, of how standards and norms emerge in decentralized economies. It shows that standardization outcomes depend on adopters' attitudes to problems caused by incompatibility. If individuals display aversion to incompatibility, standardization never fails to happen eventually, but societies sometimes end up picking inferior standards. In this case, official action can be useful to quickly achieve sensible standardization. On the other hand, when individuals display tolerance or neutrality to incompatibility, there is neither path-dependency nor a lock-in problem, and regulation seems a poor alternative to laissez-faire.


The article analyzes directions and forms of the volunteer movement to assist the Armed Forces of Ukraine, which was launched after the aggression of Russian Federation against Ukraine in 2014. It is determined that the peak of growth of volunteer movement was recorded in 2015 when more than two hundred and half of the well-known volunteer initiative associations extended their activities on the territory of Ukraine. Different in origin and social composition volunteer associations organized their work in several priority areas, the main task was the financial and humanitarian support to ATO soldiers.


This real-time system recorded raw returns and processed continuous strip-map, high-resolution (<1 m), wide-swath (37 km) imagery on-board the Convair 580 aircraft with an embedded high performance computing system costing under $100 K. The SAR image formation algorithm was optimized at all levels of the computer architecture to achieve real-time processing over 9000 times faster than the original algorithm specification. The information management system implemented a pub-sub-query environment to allow real-time offboard exploitation of the on-board multi-terabyte database within seconds. Real-time SAR image formation was demonstrated on five flight tests. The completed flights provided 7.3 terabytes of raw and processed imagery to support future algorithm research.


Provided is a marine explosion-proof electric coiled tubing power skid. The marine explosion-proof electric coiled tubing power skid comprises a skid base, a marine explosion-proof variable-frequency motor, an accumulator set, a detachable skid frame, a hydraulic oil radiator, a hydraulic oil tank, an explosion-proof electric air compressor, a steel wire rope lifting tool, an injection head power hose roller and hydraulic hose, a transfer case and a hydraulic pump set. The marine explosion-proof variable-frequency motor drives the hydraulic pump set to form hydraulic power through the transfer case to supply power to operation of explosion-proof skid-mounted coiled tubing equipment, the marine explosion-proof variable-frequency motor is utilized for replacing an explosion-proof engine to supply the power to a hydraulic system of the explosion-proof skid-mounted coiled tubing equipment, the price of the marine explosion-proof variable-frequency motor is lower, therefore, the production cost of the product can be greatly reduced; compared with the explosion-proof engine, the marine explosion-proof variable-frequency motor is mature in technology, good in reliability and short in product production cycle.


The objective of this work is to determine the optimal marketing strategies for the main destinations of argentine olive oil, inasmuch as the largest proportion of it is exported as a pure commodity. Thus, the product turns to the market without the possibility of influencing the formation of prices and defining its competitiveness based on the optimization of costs. However, an analysis of the main export destinations separately configures the opportunity to diversify the competitive strategies, in order to adapt the marketing to each particular case.For this, it was necessary to determine the most important destinations for Argentine olive oil, so we proceeded to average the exports of olive oil for each market placement in the last five years registerend by the Estatisitcs and Censuses National Institute (2011-2014). The United States of America, Brazil, Spain, Chile and Uruguay were revealed as the most important destinations in decreasing order. In order to determine the most appropriate commercial strategy for each case, the Agroalimentary Consumption Analysis Model (MACA) was applied for the last decade available in FAO data bases (2002-2011). Thus, the annual consumption of the product was taken during the referred decade and the average variation of consumption was obtained as the slope associated to a linear regression on the series. We proceeded in the same way with the consumption of the entire basket of products that compete with each other, including that of our interest.In this way, an ordered pair of data was obtained for each market (variation of the entire class to which the product belongs -VC- and variation of the product -VP). In the case in question, real consumption was estimated through the domestic supply of each country (the sum of imports, production and change in stocks minus exports) expressed in kg / inhabitant / year. Depending on the ordered pair obtained for a destination, there will be a different strategy to address it: positive VC and positive VP define a sustainable or growing market, approachable through a cost reduction strategy; Positive VC and negative VP define a vulnerable or tired market, approachable through a differentiation strategy; Negative VC and Positive VP define a strong or vigorous market, approachable by optimizing logistics and distribution; finally, negative VC and negative VP define a receding or falling market, approachable through a combination of the above strategies in a broader policy framework.In this way, the United States, Uruguay, Spain and Brazil were shown as sustainable markets, while Chile appears as a shrinking market, being determined the relevant commercial strategies according to the exposed criterion, and confirming that for a single product, the different Markets require specific strategies.


The stilling basins are commonly used to dissipate the energy and protect the downstream floor from erosion. The aim of the present experimental work is to improve the roughened stilling basin using T-shape roughness instead of the regular cubic one and design this new shape. As a result of the present work the best intensity and the best roughness length are identified. Also, it is found that the T-shape roughness save materials and reduce the jump length compared to the cubic one. Sensitivity analysis was performed and it was noticed that the change in the length of jump is more sensitive to the change in roughness length than the change in intensity.


Objective: Published data describe the use of fenoldopam in adults for treatment of oliguria/anuria and for renal perfusion and protection, but pediatric data are scant. We assessed the effects of fenoldopam on urine output and potential deleterious changes in hemodynamics or serum creatinine in children. Design: Retrospective analysis. Setting: Academic institution. Patients: All patients ≤18 yrs old at our institution who received ≥24 hrs of fenoldopam therapy. Exclusion criteria included mechanical circulatory support, initiation of fenoldopam in the operating room, and age >18 yrs. Interventions: None. Measurements and Main Results: Demographics, renal function, fenoldopam dosing, concomitant inotropes, and inotrope score data were collected and analyzed. Thirteen patients (age 0.3–18.7 yrs, median 5.5 yrs) received a mean infusion dose of 0.07 ± 0.08 &mgr;g/kg/min (range 0.01–0.26 &mgr;g/kg/min) over the first 24 hrs of therapy. Eight patients received fenoldopam to augment urine output, and five patients received fenoldopam to increase renal perfusion. Nine (69%) patients received dopamine concurrently. Mean inotrope score at the beginning of therapy was 11.3 ± 7.6 and did not change during therapy. Mean urine output increased from 1.82 ± 1.5 mL/kg/hr to 2.74 ± 1.4 mL/kg/hr (p = .009) in the first 24 hrs of fenoldopam therapy. No change in serum creatinine occurred (p not significant). Blood urea nitrogen was significantly different from baseline (41.7 ± 18.7 vs. 49.0 ± 19.8 mg/dL, p = .02). Patients with lower baseline urine output had a greater increase in urine output with fenoldopam. One patient experienced clinically significant hypotension while receiving fenoldopam, which was thought to be due to a concurrent nitroprusside infusion. Conclusions: Fenoldopam increases urine output in select critically ill pediatric patients without requiring escalation of inotropic support. There were no adverse hemodynamic effects or alterations in serum creatinine. Further prospective pediatric studies to define the role of fenoldopam in children are warranted.


: As a new model of talent training, school-enterprise cooperation education must continue to innovate and explore to promote its sustainable development. The main purpose of this paper was to explore how to use machine learning (ML) to analyze and study the mechanism of school-enterprise cooperation and the current development of school-enterprise cooperation. Aiming at the problem of school-enterprise cooperation mechanism, a school-enterprise cooperation model based on decision tree (DT) has been proposed. The related algorithms have been discussed in detail. Combined with the school-enterprise cooperation mode of higher vocational colleges in Z city, the case design and analysis were carried out. It can be seen from the questionnaire that 60.00% of the companies chose to "select new employees". 55.85% of the schools rated the school-enterprise cooperation as "average cooperation effect". It can be seen that the current school-enterprise cooperation in Z city is too simple. The level of cooperation is not high. In terms of the content of cooperation, the school has established its own professional direction according to the requirements of the enterprise, which can pave the way for the employment of school graduates. This "cooperation-employment" management model is too simple. It lacks systematic planning and lacks national policy support and assurance. On the other hand, due to the different cognitions between schools and enterprises, different departments, classes, teachers, and students also have different views. This makes it impossible to establish a flexible and effective mechanism between schools and enterprises. It also makes the students of the same major and different classes have great differences in the practical operation ability in practical application.


Hematoporphyrin derivative has been evaluated as a means of detecting malignancy in 121 patients suspected of having cancer. Areas examined included the cervix, vagina, tracheobronchial tree, esophagus, peritoneum and rectum. Dysplastic and neoplastic tissue was identified by red fluorescence whereas nonneoplastic tissue appeared grayish white to black. Thirty‐three of 35 primary malignancies of the cervix and vagina were detected by fluorescence. The technique was especially helpful for the identification of recurrent lesions. In the fluorescent endoscopy group, the region of malignancy was identified by fluorescence in 32 of the 34 cases in which the lesion was located where the activating light could reach it in sufficient intensity. Hematoporphyrin derivative is a valuable adjunct to detection and management of malignancy, especially in the patient who presents a problem of the extent, location or possible recurrence of a malignant lesion.


The electronic structure calculations for Pr3Se4 have been studied applying the density functional theory (DFT). Applying the semi-classical Boltzmann theory-based calculations, the thermoelectric properties have been calculated for undoped and optimized Pr3Se4 as a function of temperature. Due to the enhancements of power factor (PF) and electronic thermal conductivity (κe) for optimized Pr3Se4 compared to undoped compound, the electronic part of the figure of merit (ZTe) has improved. Calculations of thermoelectric properties indicate that the optimized Pr3Se4 can achieve a value of ZTe = 0.43 at 1,300 K.


Dr. Adams, no doubt, planned to produce a second volume, Par t Two: The New Testament, as a companion to this volume, Par t One: The Old Testament, under the general title Ancient Records and the Bible. It is deeply regrettable that his death interrupted his plan. Fortunately, the manu script of the present volume was practically ready for the printer before his death. The present work is an extensive survey of the results of scientific excavation and exploration, which are pertinent to the matter of the Old Testament record, and a demonstra tion of "their bearing on the integrity of the Scriptures in matters of historical detail." The chapter titles indicate the comprehensiveness of the book: I. The Old Testament World; II. The Recovery of Ancient Civilizations; III. Records from Egypt; IV. Records from Mesopotamia; V. Records from Asia Minor; VI. Records from Syria; VII. Records from Palestine; VIII. Early Hebrew Records; IX. Archaeology and Criticism; X. Old Testament Chronology; XI. The Era of the Patriarch Abraham; XII. The Mosaic Age; XIII. The Laws of Moses; XIV. The Settlement in Canaan; XV. The Hebrew Kingdoms; XVI. Dispersion and Restoration. The book encompasses in one volume the accounts, the records, and the evaluation of all discoveries that have a bearing on any matter in the Old Testament. This material had been scattered in numerous books dealing with archaeological dis coveries. It is good to have all the pertinent data in one volume.


Very few people understand the impact of suicide in the legal profession better than family lawyer Elizabeth Rusiti, whose husband, Matthew Stutsel, tragically took his own life earlier this year. She shares her powerful story of love and loss - and says it's time lawyers learned how to help themselves when it comes to mental health.


This research is motivated by the needs of society and the conditions of service business competition intensifies, so the company must create a new marketing strategy to maintain and gain market share higher. As for the issue of this research is "What are the factors of products, personnel and promotion effect on customer satisfaction in PT. Mnet Indonesia ".The purpose of this study to determine how the product implementation process, personnel and promotion are being made to improve customer satisfaction and to determine the extent of the effect of products, personnel and promotion of customer satisfaction. The hypothesis of this study is the product, personnel and promotion effect on customer satisfaction. The author uses quantitative research methods explanatory. The research sample as many as 101 customers with a 99% confidence level (α = 0.01) in. Results of multiple linear regression analysis we concluded that all the independent variables, namely products, personnel and promotion have a positive effect on the dependent variable of customer satisfaction. Based on the results of the analysis of figures obtained correlation R of 0.697. This shows that there is a strong relationship or correlation between the products, personnel and promotion of customer satisfaction. While the results of the analysis of determination (R2) of 48.6%. This shows that the percentage of the effect of independent variables on the dependent variable of 48.6%. While the remaining 51.4% influenced or explained by other variables not included in this research model.


Under the conditions of a combined mining system overburden is developed using a transport and non-transport technologies, specific costs for non-transport technology are lower than transport costs. The change in the non-transport bench height led to the redistribution of the volumes of transport and non-transport overburden. With an increase in the volume of non-transport overburden, the share of more expensive transport overburden is decreases, while the technical and economic indicators of the non-transport zone deteriorate due to an increase in re-excavation volumes. The change in the non-transport bench height affects the recasting ratio and the annual advance coal face line, which determine the cost of developing the overburden. This article presents the results of a study of the laws of change in the recasting ratio and the annual advance coal face line, depending on the non-transport bench height within a combined mining system of flat seam. The obtained patterns were established as a result of solving problems of substantiating typical excavation schemes of the direct dumping method and developing a mathematical model for identifying excavation schemes with the subsequent calculation of their technological indicators.


Abstract— Near‐to‐eye displays (NEDs) provide a unique way to perceive a larger image than the device itself. The user acceptance of commercially available NEDs has not been high partly because of reported physiological symptoms. Devices also tend to be thick and heavy, and therefore uncomfortable to wear. To overcome these shortcomings and to make a very usable device, a new approach was needed. By using very thin plastic light guides with diffractive structures on the surfaces, many of the known obstacles can be notably reduced. These exit pupil expanders (EPEs) enable a light and thin design for see‐through NEDs. The so‐called chevron EPE was designed to further improve the design and usability aspects of NEDs. The diffractive EPE has typically one incoupling grating area that delivers light into the light guide symmetrically towards the left and right eyes. By using slanted or overhanging gratings, the incoupling is very asymmetric. If the incoupling area is divided into two parts, each having opposite slanting angles, the EPE plate can be cut in half, and the left and right parts can be separated. The plates can be further tilted to a chevron shape following more closely the human face and mimicking the conventional eyeglass design. The reflection of the light from the tilted plate is directed out from the image‐forming optics, and therefore the contrast is improved. The privacy of the usage is improved because at the output the secondary beams are harder to observe. Because the device is brought closer to face, it enables better weight balance. The chevron geometry partially prevents the ambient light from the sides to enter the diffractive structures, and thus the unwanted reflections are also reduced. Furthermore, the half‐size of the chevron EPE parts from the undivided EPE results in a better production yield.


In order to meet US tritium needs to maintain the nuclear weapons deterrent, the Department of Energy (DOE) is pursuing a dual track program to provide a new tritium source. A record of decision is planned for late in 1998 to select either the Accelerator Production of Tritium (APT) or the Commercial Light Water Reactor (CLWR) as the technology for new tritium production in the next century. To support this decision, an APT Project was undertaken to develop an accelerator design capable of producing 3 kg of tritium per year by 2007. This paper will briefly describe the APT facility, and then summarize preparation activities at SRS for APT.


The concept of the Vision-Pad, a new approach for a device supporting the interaction of man and machine is presented. It is based on an image pick-up system, which detects a hand's or pointing device's position over a panel. This information is processed by the system to feedback the hand's position to the user using the computer's or machine's standard display device. By this concept no direct view to the panel, no change of view directions, and no distance adaptations of the eyes are needed to obtain a reliable input. These features allow a safe and comfortable input especially in critical environments, such as e.g. cars, as well as help for disabled people. A demonstrator based on a plastic optical fibre is realized, which shows the applicability of the basic concept in various environments even with changing illumination conditions. Moreover, the possibility for a realization using little computational power and minimum hardware expense is pointed out.


Aluminium 6111-T4 large curvature radius of pure bending springback examples being put forward in the NUMISHEET'2002 session was adopted to research springback angle and forming force of the different sheet rolling directions.Based on the Hill'48 yield criterion and Barlat'89 yield criterion from the finite element analysis software eta/Dynaform,finite element simulation was conducted.During this study process,the exponential hardening model and linear hardening model were used.Comparing the simulated results with the experimental results,it shows that the punch pressure increases with the increasing of the punch stroke,the springback angle increases as well;the simulated springback accuracy value is the highest and the error is 8.86% by adopting the Barlat'89 yield criterion and index hardening model,and the springback accuracy value obtained by adopting the Hill'48 yield criterion and index hardening model is smaller and the error is 14.67%;the mode of yield criterion has larger effects on springback value than hardening expression,and the hardening mode has little effect on springback value.


This study examines the depiction of violence in Disney films by investigating the relation between violence and the characters from the 1930's until today with focus on a gender perspective. The f ...


Persistent pain infrequently complicates injury to bone, soft tissue, and peripheral nerve. Reflex sympathetic dystrophy (RSD) is a generic term used to indicate a clinical syndrome consisting of pain (usually burning in quality), hyperpathia, dystrophic changes in skin, nails, and subcutaneous tissues, and sympathetic dysfunction occurring in response to bone and soft tissue injury. Causalgia is a special type of RSD complicating partial injury to peripheral nerve in which there is intense pain, sympathetic dysfunction, and dystrophic changes in the limb, and often a beneficial response to sympathetic blockade. Current available treatments of neuropathic pain, and the proposed mechanisms of pain, hyperalgesia, and sympathetic dysfunction occurring in the RSDs, will be reviewed. An approach to the management of patients with RSD will be proposed.


Heart failure (HF) is a syndrome with complex pathophysiology, the various clinical phenotypes of which pose both diagnostic and therapeutic challenges. The signs and symptoms of HF have neither good sensitivity nor specificity for diagnosis. Levels of natriuretic peptides (NPs; i.e. BNP, NT-proBNP, MR-proANP) correlate with left ventricular (LV) wall stress and increase with higher LV filling pressures, and markedly elevated levels are seen in manifest HF. The European Society of Cardiology (ESC) guidelines1 recommend the use of NP levels in algorithms used to diagnose HF, but cut-off values are helpful mostly for the purposes of ruling out HF and cannot be used to rule in such a diagnosis. Levels of NPs are also increased in other cardiac disorders and in non-cardiac disease such as renal dysfunction. Echocardiography with evaluation of LV ejection fraction (EF) and diastolic function is central to the diagnosis of HF. However, LV systolic dysfunction and, in particular, impaired diastolic function occur frequently in the asymptomatic elderly population2 and only the elevation of filling pressures causing symptoms can be classified as indicating clinical HF. Consequently, the use of all available information and the process of putting the pieces together in the clinical context are fundamental to achieving a correct diagnosis in both HF with reduced EF (HFrEF) and HF with preserved EF (HFpEF). Congestion is the main driver of worsening HF symptoms. It can manifest either as venous (systemic) congestion affecting organs such as the kidney, liver and gut, or as pulmonary congestion, the main cause of dyspnoea in HF. Pulmonary congestion in HF is primarily the result of elevated LV filling pressures and frequently coexists with venous congestion and fluid retention. Lung ultrasonography (LUS) is a non-invasive method of making a semi-quantitative assessment of pulmonary congestion and more directly a measure of extravascular lung water content.3 In the 'wet'


Defects in both coagulation initiation and fibrinolysis have been identified in Chronic Kidney Disease (CKD) patients and patients on dialysis may have higher rates of Cardiovascular Disease (CVD) events.


AIM: To evaluate the efficacy of hepatic arterial infusion chemotherapy (HAIC) based on oxaliplatin for treatment of the patients with multiple liver metastases from colorectal cancer. METHODS: Twenty-six patients (treatment group) with multiple liver metastases from colorectal cancer were treated 58 times by HAIC and embolotherapy, and chemotherapeutic agents used were oxaliplatin 130 mg/m2, leucovorin 200 mg/m2, 5-fluorouracil 750 mg/m2. Meanwhile, 20 patients (control group) were treated with modified FOLFOX4 regimen. Preliminary efficacy, change of body state and post-chemotherapy toxic reaction were observed and compared between the 2 groups. RESULTS: Preliminary efficacy of treatment group was prior to that of control group obviously (57.7% vs 40.0%,P0.05); Karmofsky scores were raised after treatment in treatment group (P0.05), while they were degraded in control group (P0.05); side effects of treatment group were lighter than those of control group, such as nausea and vomiting (P0.05). CONCLUSION: Compared with FOLFOX4 regimen, HAIC based on oxaliplatin can enhance preliminary therapeutic efficacy.


Short rigorous solutions to three mathematizations of the famous Monty Hall problem are given: asking for an unconditional probability, a conditional probabiliity, or for a game theoretic strategy. It is concluded which mathematicization ought to be considere da s the Only True Solution of the True Monty Hall Problem: the little known Game Theoretical version.


An aqueous dispersion based on an acid-protonized reaction product from (a) Mannich bases free from epoxide groups, from (a1) condensed phenols free from ether groups with at least two aromatic rings and with at least two phenolic hydroxyl groups and/or (a2) condensed phenols, containing ether groups, with at least two aromatic rings and at least one phenolic hydroxyl group (a3) secondary amines with at least one hydroxyalkyl group, possible in a mixture with (a4) secondary dialkylamines or dialkoxyalkylamines without free hydroxyl groups, (a5) formaldehyde or compounds splitting off formaldehyde, with (b) epoxide resins, aliphatic hydroxyl groups from (a) and/or (b) being converted at least in part into urethane groups possibly by reaction with partly blocked isocyanates, containing furthermore fine-particulates non-ionic plastics in dispersed form. The dispersion and/or the fine-particulate plastics furthermore may contain pigments and/or fillers. The dispersion is suitable as an electro-dip means for coating on electrically conducting substrates acting as the cathodes in an electro-dip enameling process.


The origin of ideological and political education blog is introduced.It is clarified that the ideological and political education blog has played a positive role on counselors by broadening the platform,strengthening timeliness and interaction,promoting the vocational development of counselors and innovating the formation and environment.The development situation and the existing problems including unrich content,slow updation and no timely message reply in ideological and political education blog are analyzed.Some suggestions about the content construction,building of evaluation and stimulation mechanism and setting up regional blog circle of ideological and political education blog are put forward.


A series of phenyl end-capped derivatives of benzo[d,d′]thieno[3,2-b;4,5- b′]dithiophene (BTDT) with periphery-fluorinated substitutions (PFS) were systematically investigated by using density functional theory (DFT) combined with the Marcus–Hush electron transfer theory. The substituting effects of PFS were discussed. Compared with the original compounds, (i) the PFS compounds have a relatively higher efficiency of charge transport, lower barriers of electron injection, and larger HOMO-LUMO gaps; (ii) the air-stability and the device performance are enhanced by PFS; and (iii) the HOMO-LUMO transitions in the absorption spectrum of the PFS compounds show an obvious blue-shift trend. The perfluorophenylbisbenzo[d, d′]thieno[3,2-b;4,5-b′]dithiophene (BpF-BTDT) is found to be the most stable and most effective compound in charge transport among the investigated compounds, and it is suggested as an ambipolar semiconducting material. The results of electronic coupling of the bisbenzo[d, d′]thieno[3,2-b; 4,5- b′]dithiophene (BBTDT) derivatives show that the orbital interaction is mainly contributed by the neighboring molecule in the two dimensional (2D) layer. The PFS compounds have lower oxidization potential, ionization potential, and electron affinity values than the corresponding original ones, which suggest that fluorination can enhance the performance of the thiophene-based organic solar cells. These findings provide a better understanding of the PFS effects on organic semiconductors and may help to design high-performance semiconductor materials.


This study empirically analysed the effect of material management on the profitability of small poultry enterprises using City Poultry Enterprise, Umuahia as a case study. The monthly material records of the enterprise from 2011-2012 was used for the study. The study used regression and correlation analyses to examine the effect and relationship between purchase, work-in-progress and finished goods on the profits and sales of small poultry enterprises. It was found that proper materials management enhances the profit of the enterprise. It is, therefore, recommended that firms should formulate and maintain proper material management policy.


A suitable environmental flow is critical for the functional maintenance of riverine ecosystems. Hydropower plants alter the flow regime by decreasing or even drying up the streamflow downstream of the dams, thereby affecting ecosystem sustainability. In this study, we aimed to develop a robust environmental flow framework that can provide scientific evidence for sustainable water resource management. Using ecological niche modeling based on non-linear responses of species to habitat factors, we assessed the environmental flow in the Xiangxi River Basin of Central China during dry and wet seasons from a multi-year perspective. The most abundant macroinvertebrate taxon (i.e., Baetis) was selected for model testing. The results showed seasonal differences in the minimum ecological water requirements and optimal environmental flow. These two hydrological metrics were higher during the wet season than during the dry season. During the dry season, the minimum ecological water requirement of Baetis was 1.3 m3·s−1, and the optimal environmental flow was 1.6 m3·s−1. During the wet season, the minimum ecological water requirement of Baetis was 2.5 m3·s−1, and the optimal environmental flow was 2.6 m3·s−1. This study provides a theoretical basis for the robust management of water resources in river basins.


Langerhans cell histiocytosis (LCH) formerly known as histiocytosis X is rare spectrum of disease characterized by a monoclonal proliferation of bone marrow-derived Langerhans cells. LCH involves the head and neck region quite commonly, in particularly the bones of the skull and jaws. This is a case report of 14 years old female, presented with a complaint of intermittent abdominal pain, short stature and delayed puberty, which was subsequently presented with pain and swelling on left side upper premolar region with bleeding gums, which was finally histopathologically diagnosed as Langerhans cell histiocytosis following an incisional biopsy.


Mao Zedong in the early period of democratic revolution and nation-building, whether in the face of the great victories and achievements, or face the whole Party and people for his sincere support, he maintained a Marxist does not claim credit proud of modest and prudent, firmly opposed to great style personality cult. But since 1957, due to various complicated reasons, especially Mao Zedong's subjective reasons, he not only maintained a relatively sober-minded, not in favor of a personality cult, but also that the need for political struggle, can and need to engage in their personal worship. As a result, the personality cult frenzy intensified, so that our party and the country suffered heavy losses. Mao Zedong's personality cult around on the issue of change and its failure teaches us that we must correctly understand and deal with individuals and organizations, the relationship between the leaders and the party must always remain modest and prudent and strict laws have been in close contact with the masses of the style, we must improve and uphold the Party's principle of democratic centralism and collective leadership system.


This presentation explores the structure of curriculum development programmes in FE ITE to see the extent to which they help to promote curriculum research. Given the desire to promote research informed teaching, it argues that trainee teachers need to be equipped with the skills required for carrying out research on specific issues. Using the existing paradigm of the theoretric and the practical, it suggests that the current programmes are more theoretically orientated. It then draws on elements of the programmes to demonstrate how the existing focus can be made more practical.


There is provided a pellet composition of ruminant feed which reduces the risk of acidosis in the rumen and a process of making such ruminant feed.


The aim of this study is to identify the internal and external factors in the company after being taken over by the Government of Indonesia from Japanese investors and to formulate appropriate strategies to improve the performance of the company after the takeover by Indonesian government to be supporting the national aluminum industry that can fulfill the needs of the domestic aluminum and simultaneously increase profitability. This type of research is action research, with a population of 78 (seventy eight), which consists of five Directors, 21, General Managers, 49 Managers and 3 consultants in the aluminum industry. Data were analyzed with IFE and EFE matrix, then analysed by SWOT analysis and IE Matrix which produces Grow and Build strategy with the strategies used are either integrative strategy of backward integration, forward integration, as well as horizontal integration and diversification.


Microbially enhanced coal-bed methane (MECBM) production is an innovative idea to stimulate biogenic coal-bed methane production by providing nutrients to the native microbial community. Through additional substrate in the subsurface, a stimulation of microbes occurs, which leads to an increased methane production. Experimental studies, performed at Montana State University, provide the basis for modelling MECBM production with two-phase multi-component transport processes using the numerical simulator DuMuX [1].


Recent breakthroughs in wireless charging technologies have greatly promoted the development of rechargeable wireless sensor networks (WSNs). To improve the lifetime of WSNs in many applications, the charging efficiency of mobile chargers (MCs) and the energy supplement of MCs should be improved. Although optimized charging path schemes in WSNs have been studied extensively, little attention has been paid to determine the energy consumption of MCs while charging and their movement during the charging tasks. In this paper, we analyze the relationship of the movement energy consumption of MCs and their energy transfer to the nodes and put forward our algorithm for improving the charging efficiency of the MCs. We divide the entire network into different charging regions and propose three charging schemes based on different situations in each region. The idea of cooperation among the MCs to charge MCs further enhances the charging efficiency of the MCs. A simulation demonstrates the advantages of our algorithm for improving the lifetime and charging efficiency of the MCs. This paper aims to improve the lifetime of WSNs and to decrease the cost for charging nodes and results in a longer lifetime for WSNs in applications with limited energy.


It's amazing. The lawyers make the malpractice laws, witch hunt until a case is found, and then take a large portion of any award given. They are not satisfied with that. Robert V. Wills, JD, writing in Surgical Rounds gives we physicians three maxims on how to react when slapped with a malpractice suit.
 The lawyers don't want the physicians to get upset or overreact when accused of negligence, carelessness, or reckless behavior. Wills reminds us there is better than a 50/50 chance of resolution of the claim in the doctor's favor. These cases should be treated as an economic nuisance and you may not be the primary defendant. He further suggests physicians regard a malpractice claim as a "cost of doing business."
 Are we going to accept this advice so kindly offered by the legal councilors? After all, they don't give free advice often. The medical profession is special in many ways. Therefore, any allegation of wrongdoing or mistreatment of a patient must be addressed by that profession the best way available. The medical profession should never approach the malpractice crisis in this country with an attitude of "economic nuisance" or percent chances of resolution in the doctor's favor.
 The physician's attitude and feelings toward a malpractice action are more accurately described by a fellow physician, Dave Ellison, MD, in the piece "Not Guilty." These cases are a direct attack on the competence and integrity of the victim—physician. Let's take the advice of Dr. Ellison and show our colleagues who are sued, respect, compassion, and concern. Unknowingly, he put in prospective the lawyer's maxims when he wrote "[it's] no more useful than advising a depressed patient to "cheer up!" We need not look outside of our profession to advise us on our behavior in this difficult situation.


Objective To explore the biological effect of macrophage colony-stimulating factor(M-CSF) and its receptor(c-fms) in the process of monocyte/macrophage in infective endocarditis(IE).Methods 32 rabbits were divided into 4 groups by the means of hurting the cardiac valve through the injection of two kinds dose of the grape coccus,and the rabbits were put to death 24 hours later operation.Take out the cardiac valve and observe them through the eyes and electron microscope.Detect the change of M-CSF,c-fms in different valves by way of RT-PCR.Results 26 rabbits survived after operation,53.8%(14/26) were found infective endocarditis;low dose S.aureus injection was remarkable lower than high dose S.aureus injection in vegetation induction and the positive rate of bacterial culture(P0.05).the mitral and tricuspid valve were induced be operation and bacteria injection.The expression of M-CSF mRNA clearly increased(P0.05),and the expression of c-fms mRNA decreased clearly;High dose S aureus injection lead more M-CSF expression in mitral valves than low dose S.aureus injection(P0.01),but not in tricuspidal valves.Conclusion High dose bacterial invasion and heart valves lesion were the main factor to lead to infective endocarditis.There were different M-CSF/c-fms reaction between left and right cardiac chamber with valve lesion and bacterial invasion,this maybe the reason of different probability of left and right cardiac chamber in infective endocarditis.


The year 1930 dawned upon a world which was moving from what appeared to many at the time to be a high plateau of prosperity into a deep valley of economic depression. In that year the White House Conference on Child Health and Protection recorded the tremendous progress made in scientific knowledge, and in the Children's Charter asserted the right of children to benefit from the results of this progress. Yet, almost immediately, the primary essential of child welfare-namely, a living wage for the father-was challenged by the onset of the depression, and in a very few years more than six million children were living in families on relief. By 1940 the White House Conference on Children in a Democracy reported that more than a million families in this country had a yearly income below $250 and that two-fifths of all families had incomes under $1,000. The year 1930 dawned upon a world at peace. But the decade which witnessed so many attempts to preserve peace and to promote international cooperation in the solution of social and economic problems ended with part of the world at war and most of the world fearing war. During the early part of the decade international co-operation in behalf of the welfare of children through such agencies as the Social Questions Section of the League of Nations, the International Labor Organization, and the Pan American Child Congresses was increasingly effective, tending to raise standards in the fields of health protection, child labor legislation and regulation, and care of dependent, neglected, and delinquent children. By the end of the decade the outbreak of war in Europe had swept away many previous gains, and in the United States had brought vigorous effort to preserve the gains so hardly won during the depression years. During this decade of unprecedented stress and strain, the lives of children were subjected to crosscurrents and influences the final effect of which is as yet not clear. Specific events may be listed in chronological order. Definite gains as well as definite losses may be tabulated. What the final balance sheet will reveal cannot be accurately predicted. But from a review of the decade one outstanding fact emerges--the deepening sense of public responsibility for children and the accompanying realization that this responsibility must be developed on a nationwide basis. This fact stands out with increasing clearness when the general term "child welfare" is broken down into some of its major component parts and the record of the last ten years is examined in greater detail in the closely related fields of maternal and child health, education, social welfare, control of child labor, and provision for leisure-time activity, recreation, vocational guidance, and opportunity for useful employment.


ABSTRACT Pregnancy is a critical time period for supporting food security and maternal nutrition because of long-term potential impacts on the developing fetus. We conducted a pre-/post-analysis of pregnant WIC participants (n = 592) in San Francisco receiving $40/month of fruit and vegetable vouchers in addition to the standard WIC package. We compared pre-/post- changes to a comparison group of non-pregnant WIC participants (n = 108) receiving only the standard WIC package. We observed significant improvements in food security and mean daily frequency of total vegetables, combined fruits and vegetables, salad and non-fried potatoes (p < .05 for all comparisons).


The system integration approach of education in the methodical system of preparation of the future Ukrainian language teacher is described in the article on the basis of the usage of theoretical, observational historical and logical methods. The article explains the concepts of "approach" and "approach to language learning". The author defines "approach" as an integrative system architectonics of linguistic theory, linguistics, practical skills and foundations of the scientific activity based on principles, methods, techniques, tools and forms of learning, according to the specific educational goals of linguistic formation competencies of the future Ukrainian language teachers. The terms "approach" and "aspect" of learning are analyzed in this paper, and their identity, which is based on the analysis of scientific sources, is established. The classifications of approaches to teaching in pedagogy and linguistics are reviewed. Competent, cognitive-communicative, communicative-active, text-centric, functional-stylistic approaches are defined as the main ones in the study. The expediency of using a system integration approach to the formation of a linguistic competence of the future Ukrainian language teachers (the components of which are phonetic, lexicological, grammatical, spelling, stylistic subcompetences), based on the study of linguistic courses in their harmonized, subordinate and complementary system, with an emphasis on the study of the information volume of the disciplines, where each linguistic phenomenon is considered holistically and in a clear hierarchy, is justified. The lexicographic analysis of the definitions "system" and "integrative" as the initial concepts of a system integration approach has been carried out. The system of linguistic disciplines, including ten courses (Ukrainian language practicum, Modern Ukrainian literary language, Introduction to linguistics, Ukrainian dialectology, Language culture, Ancient Slavic language, History of the Ukrainian language, Historical grammar of the Ukrainian language, Ukrainian language stylistics, General linguistics, Linguistic analysis of the text), constituting subsystems, which, interacting clearly, represent linguistic science, the complexity of its structure, multidimensionality aspects, is given. The scheme of a system-integration approach that demonstrates the integrity and consistency of mastering linguistic disciplines is proposed. The opportunities to integrate on linguistic theme that will promote the versatile assimilation with the prospect of study acts school are described.


T he following is an update of our article published in the April 22, 2011 issue of Antitrust & Trade Regulation Report (100 ATRR 441) regarding the Federal Trade Commission (''FTC'') and Department of Justice (''DOJ,'' collectively the ''Agencies''), Statement of Antitrust Enforcement Policy Regarding Accountable Care Organizations Participating in the Medicare Shared Savings Program (the ''Policy Statement'').


Parentage and Ancestry Frederick Gowland Hopkins was born in 1861 at Eastbourne, whither hisparents had moved on their marriage. His paternal great-grandfather was a Captain Hopkins, R.N., who, according to family tradition, commanded a ship at Trafalgar. The Captain is said to have had a large family, and some of the sons, including our subject's grandfather, went into business in London. Two other members of this family deserve special mention. One of them, Manley Hopkins, became Consul-General for the Hawaiian Islands to Great Britain, and his eldest son was Gerard Manley Hopkins, the Jesuit poet. According to the biographer of the latter, G. F. Lahey, S.J., the father was also a man of high intellectual endowment and something of a poet. Hopkins could remember that, as a boy, he was taken by his mother to visit the family of Manley Hopkins, uncle of his late father, and that the son Gerard, the poet, was present, though he did not recall him very clearly from that memory of childhood. The other member of the Captain's family to be mentioned, as having through her descendants made contact with our subject's life and career, is Louisa, who married Johann Leopold Abel, a German by birth. Among the offspring of this marriage was Frederick Augustus Abel (later Sir Frederick Abel, Bt.), who became eminent as a chemist and, in particular, an authority on the chemistry of explosives. He did important work for the British Government in that field, was elected F.R.S. in 1860 and was a close friend of his cousin, our Hopkins's father. A younger brother of Frederick Abel became, through a daughter, the grandfather of Carl Frederick Abel Pantin, F.R.S., who was to be a colleague of Hopkins, as a Fellow of Trinity College, Cambridge. To return to the direct line of ancestry, Hopkins's paternal grandfather settled in Bishopsgate Street* in the City of London, as a bookseller and an occasional publisher, and there his son, Hopkins's father, was born and educated, entered business and continued to live until he married.


This paper presents universal testing system and its communication mechanisms. The system is dedicated for electronic devices testing and configuration during final stage of manufacturing. System construction was designed for quality control, efficient work, easy self-diagnostics, economic new device types deploying. Introduction of this paper contains reference to other systems and popular methods of electronic devices testing [1, 2]. In the next clause system architecture [3] was under discussion. Easy in-circuit testing method based on special prepared testing program loaded to microcontroller of tested device was applied in the system. Physical connections of system elements were shown (Fig. 1). The third unit contains description of tester functionality [4] and functional block diagram (Fig. 2). The next part presents tiered architecture of communication between tester and control application (Fig. 3), SCPI based communication protocol [6], command exchange mechanisms between control application, tester and database server in command flow diagram (Fig. 4), aspects of test logic designing. Start of testing process is connected with loading plug-in library with test logic definition. System emphasizes on minimal required staff skills which means both ease of application use and rapid test design process. Functionality of presented system is sufficient for testing electronic devices and makes possible to detect many potential damages.


The method of reconstructing acceleration field was studied based on inversion of frequency response function matrix. In the method, the frequency response function (FRF) matrix was obtained. The vibration test was carried out and the test object was an underwater vehicle power-cabin. The results of theory study and test showed that the calculated precision by this method can satisfy the needs of the engineering application.


QFN devices are mall,light,and sensitive to the rework temperature.Their peripheral devices are arranged intensively.The high temperature will affect its reliability,so the demand for rework temperatures profile is higher.At the same time,QFN needs to be baked for the moisture sensitivity before rework.After resoldering,the residue on the pad needs to be cleaned up,and need to pay attention to the selection of solder-wick and soldering iron tip finally.Give out the solutions for above-mentioned problems,and expound QFN rework technology.


The life history of Greta diaphana (Drury) (Ithomiinae) (assigned to ssp. charadra Schwartz) from the Cordillera Central in the Republica Dominicana. island of Hispaniola, is described, and its food plant, Cestrurn coelophlebium O. E. Schulz (Solanaceae) is reported. Only 2 species of Ithomiinae clearwing butterflies occur in the West Indies north of Trinidad. Both are in the genus Greta, which is also known from mainland tropical America. Greta cubana (Herrich-Schaffer) is restricted to the forested mountains of Cuba, Greta diaphana (Drury) has 5 named subspecies: one on Jamaica, and four in different parts of the Dominican Republic (Schwartz, 1982). Aside from brief notes by Turner (published in Smith et al., 1994) on one pupa of G. diaphana diaphana from Jamaica, the immature stages of G. diaphana remain largely unknown.


The aim of this study was to evaluate the optimization extrusion variables on quality of textured vegetable protein by using response surface methodology. In this study, 50% soy protein isolate, 40% wheat gluten, and 10% corn starch were blended and 15% of the mixture was substituted with green tea. The moisture content (45, 50, and 55%), barrel temperature (130, 140, and 150oC), and screw speed (100, 150, and 200 rpm) were varied. A Box- Behnken design was used in this experiment. Second order polynomial regression equations were developed to relate the response to extrusion variables as well as to obtain a response surface plot. The independent variables had significant effects on the quality of the products and moisture content was the most significant. The lower moisture content led to the higher integrity index, lower nitrogen solubility index, lower water absorption capacity, higher texture, and higher cutting strength. The optimum conditions were identified as moisture content 47.78%, barrel temperature 150.00oC, and screw speed 196.05 rpm. Incorporation of green tea into protein materials could effectively improve the nutritional value of the product. Understanding these optimized extrusion variables on the product quality was useful for producing textured vegetable protein in the future.


The study discusses the means used in the translation process by Jan Andrzej Morsztyn to transform Pierre Corneille's Le Cid, so as to fit the cultural context of Polish Sarmatism and become an instrument of propaganda of the French presence on the Polish throne and reinforcement of the king's power.


Summary The effects of a series of steroids on the carbohydrate metabolism of the bird were studied using blood glucose and liver glycogen as endpoints. The highly active compounds in the hyperglycemic reaction were hydrocortisone and corticosterone and the active compounds in the liver glycogen test were the above two plus 11-dehydrocorti-costerone. Cortisone was inactive in both tests and 11-desoxycorticosterone acetate was tested only in the hyperglycemia reaction and was inactive. If hydrocortisone is assigned an activity of 100 in the glycogen test, then corticosterone shows an activity of 12.5 and 11-dehydrocorticosterone an activity of 1. In direct contrast to the mammal, cortisone is inactive in the bird. Testosterone appears to lower blood glucose but this apparently is a result of an increase in red blood cell number rather than an absolute drop in glucose present in the blood. Stilboestrol had no effect on blood glucose levels.


Rolf Kudritzki and co-workers at the IfA, University of Hawaii (and elsewhere) have, over the past 14 years, been developing techniques to use low resolution spectroscopy of distant B-A supergiants to measure stellar metallicity, surface gravities, reddening and extinction, absolute bolometric magnitudes and distances. With the current 8-10 metre class telescopes the technique permits these measurements out to distances approaching 10Mpc. This talk will be about their latest methods and their


In view of the broad range of topics covered by Commission 48, and the consequent inevitable overlap with other commissions, it is not feasible to produce a comprehensive self-contained report. The commission therefore decided to restrict its report to a selected list of accessible recent review articles and conference reports, wherein up-to-date summaries of various topics can be found. Such a list is given below:


ABSTRACT The presence of nodosaurid ankylosaurs in the Lance, Hell Creek, and Laramie formations of western North America is confirmed, thereby extending the geochronological range of this family into the Maastrichtian (Lancian). The material includes a cervical spine and a skull referable to Edmontonia sp., and numerous teeth, plates and a basioccipital, which are questionably assigned to Edmontonia sp. Comparison of the amount of nodosaurid material known from the Judith River Formation (Campanian) with that from the Lancian deposits indicates a substantial decrease in the relative abundance of nodosaurids in the Maastrichtian. Furthermore, the stratigraphic distribution of these nodosaurs is apparently limited to the lower part of the Lancian deposits, suggesting that they became extinct before the end of the Cretaceous. If true, this would support the hypothesis that the dinosaur extinction at the end of the Maastrichtian was gradual, not catastrophic.


The development of a novel technique utilizing a postchannel gap reactor for derivatization with channel electrophoresis and laser-induced fluorescence detection is described. The reactor is made by creating a gap in the top channel plate. The channel is constructed using 25-μm spacers with a gap of 20–30 μm. A derivatizing reagent is added to the gap and allowed to diffuse into the channel and reacts with the analytes as they migrate past the gap. Separations of amino acids and a protein have been accomplished with naphthalene dicarboxaldehyde/2-mercaptoethanol postchannel derivatization and laser-induced fluorescence detection. A linear response is reported for detection of each analyte tested. Mass detection limits obtained for the amino acids are in the attomole range while that for the protein transferrin is 110 zmol. © 2000 John Wiley & Sons, Inc. J Micro Sep 12: 279–284, 2000


Two patients with myxoma of the left atrium were studied by left heart catheterization and cineangiography, and the diagnosis was confirmed at operation in both cases. An electrocardiographic timing signal on the cineradiographs permitted correlation of heart sounds and pressure waves with movement of the tumor between the left atrium and the left ventricle. In early systole, the tumor suddenly moved from the left ventricle to the left atrium, and a notch in the rising left ventricular pressure, a prominent c wave, and loud, late elements of the first sound were noted. In early diastole, the tumor moved rapidly through the mitral valve, causing an abrupt diminution in the left atrial volume, thus causing a rapid y descent despite severe obstruction of the mitral valve. An early diastolic sound, thought to be an opening snap, appeared to be related to the checking of the tumor in the left ventricle ("tumor plop").The unusual left atrial pressure pulse seen in these two cases resembles data from other cases of myxoma reported in the literature, and recognition of these unusual pressures may permit accurate preoperative diagnosis in other patients. Diagnostic changes may be present on apexcardiograms.


This weighty book (540 pages) provides a comprehensive (and beyond) introduction to critical psychology. It works on a number of levels and this can be attributed both to the clarity of structure adopted and the transparency of communication. The topic area of critical psychology is not an easy one to write lucidly about. Indeed, critical psychology is one of the few areas that students would be well instructed to read a textbook rather than the usual call to read primary sources. Primary sources in this field are often turgid and opaque / criticisms which do not apply to this text. The book is an edited collection by Derek Hook, with two consulting editors (Erica Burman and Ian Parker) and is organised into three sections which underpin the key message of the book / critical psychology or psychologies as an approach rather than a theory. Each section has an editor who is embedded in the South African context. Three sections are theoretical resources (Antony Collins, ed.), the South African context (Peace Kiguwa, ed.) and forms of practice (Nhlanhla Mkhize, ed.). The range of chapters therein is necessarily wide and cover diverse areas such as black psychology, psychoanalysis, sociocultural approaches to psychology, participatory action research and feminist critical psychology in South Africa. Each chapter is clearly signposted around core common features such as learning outcomes, introduction, summary/ conclusion, critical thinking questions and recommended readings. Such a structure lends itself well to teaching not only undergraduates but provides a potentially useful springboard for postgraduate independent learning and research. In section one (the theoretical resources) chapters focus simultaneously on engaging the reader in critical psychology frameworks and contextualising these within a particular South Africa context. The landscape drawn upon here is both historically wide and relevant. Old 'favourites'; Foucault, Fanon, Vygotsky, Bakhtin and Marx are given a thorough grounding and a South African twist. The psychological imperialism of Western psychology, 'first world' knowledge is critically contested. Indeed, chapter authors often refer to psychologies rather than a dominant homogenous psychology. In section two 'The South African context', the focus is more explicitly on postapartheid South Africa. Here the role of applying psychology in areas such as black consciousness raising, HIV/Aids prevention, community settings and feminism is interrogated within the complex South Africa sociopolitical arena. This is both the strength of the book and a potentially missed marketing opportunity. The South African culture and practices outlined here create the possibility for psychologists (and


In the unweighted set-cover problem we are given a set of elements E={ e1,e2, ...,en } and a collection $\cal F$ of subsets of E. The problem is to compute a sub-collection SOL⊆$\cal F$ such that $\bigcup_{S_j\in SOL}S_j=E$ and its size |SOL| is minimized. When |S|≤k for all $S\in\cal F$ we obtain the unweighted k-set cover problem. It is well known that the greedy algorithm is an Hk-approximation algorithm for the unweighted k-set cover, where $H_k=\sum_{i=1}^k {1 \over i}$ is the k-th harmonic number, and that this bound on the approximation ratio of the greedy algorithm, is tight for all constant values of k. Since the set cover problem is a fundamental problem, there is an ongoing research effort to improve this approximation ratio using modifications of the greedy algorithm. The previous best improvement of the greedy algorithm is an $\left( H_k-{1\over 2}\right)$-approximation algorithm. In this paper we present a new $\left( H_k-{196\over 390}\right)$-approximation algorithm for k ≥4 that improves the previous best approximation ratio for all values of k≥4 . Our algorithm is based on combining local search during various stages of the greedy algorithm.


Graphene is a single atom monolayer of carbon atoms, has many applications in optics and optoelectronics [1] competing important applications in nanoelectronics [2]. Several methods are used to fabricate graphene: mechanical exfoliation, epitaxial growth and advanced chemical vapor deposition (CVD) techniques [3]. Graphene monolayer flakes, obtained via mechanical exfoliation and deposited over interdigitated (IDT) electrodes, were recently used for the photodetection at 1.55 μm with a responsivity of 6.1 mA/W [4]. Lately, graphene inks are a promising alternative for graphene device implementation especially in optoelectronic domain (see Ref. 5 and the references herein). In this communication, we have used a combination of top-down and bottom-up approaches to fabricate a graphene photodetector. Our device consists of a MSM IDT bimetallic electrodes (Au/Pt) array (see Figure 1a) deposited on high resistivity (HR) Si wafer over which gold decorated graphene dispersion has been casted.


A smart city is the global development vision to integrate multiple information and communication technology (ICT) solutions in a secure and simple way to manage a city's assets. Smart transportation is the basic component in future smart cities. Thus we are concentrating on the street light automation by detection of motion of object. Lighting which is not necessary can be neglected by targeted dimming of area of the city, town, roads or individual luminaries. The main objective of street light automation is to reduce the power consumption occurring due to lightening of street light during night when there is no objective motion on the street. During day time, the lights will be turned off and during night it will be turned on. In street light automation we are using Pulse Width Modulation (PWM) technique to control the light intensity in different condition like day, night, no vehicle condition & vehicle condition. In this paper we are working on street light automation by means of self responsive cars with collision avoidance system.


Summary

A long-term tillage experiment near Edinburgh on two soils types, one suitable for direct drilling and the other not, allowed comparisons to be made of soil responses to tillage and traffic.

For all tillage treatments tests, bulk density was always higher and air capacity lower on the soil unsuitable for direct drilling. Cone resistance, while dependent on treatment, was independent of soil type, The results suggested that compactability influences soil suitability for direct drilling.

Differences between soils in compactability were greater under direct drilling than other tillage treatments or in laboratory tests, probably due to the interaction of traffic and drainage regime. Drainage was not impaired under direct drillingon either soil type, despite significant reductions in macro-porosity. Crop yields and root distribution in relation to soil physical conditions suggested the increased importance of subsoil conditions in direct drilling compared with ploughing systems.


We present a novel approach of millimetre wave power generation using active microstructured nonlinear transmission line (NLTL) oscillators consisting of a periodic array of resonant tunneling diodes (RTDs). RTD‐NLTLs resonators have been measured to operate as distributed oscillators up to 50 GHz with power output up to −10 dBm. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2907–2909, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22902


Reporting repair of skin lacerations can seem complicated by the number of codes and length of prefatory language appearing with Current Procedural Terminology (CPT®) codes for wound repair. However, most lacerations only require consideration of 3 factors…


The utility model discloses an overhead steam conveying pipeline, comprising an inner working pipe, an insulating layer, a fixed component and an outer protective tube which are sequentially arranged from inside to outside, wherein the insulating layer comprises an outer insulating layer and an inner insulating layer, a centrifugal glass cotton insulating layer is used as the outer insulating layer, and a silica aerogel insulating layer is used as the inner insulating layer. According to the overhead steam conveying pipeline disclosed by the utility model, heat preservation performance can be greatly improved, heat energy loss is reduced, cost is lowered and space utilization rate is improved.


To ensure the minimum miss quantity when the radar homing antiaircraft missile encounters target,elements affecting the line of sight(LOS) angular velocity of the missile were analyzed.Two optimization factors including longitudinal acceleration and gravity were obtained by using the conditions of minimum required overload while missile hitting,which could compensate the LOS rotation rate and trajectory curvature.The trajectory optimization by proportional guidance was accomplished.The simulation results show that the method has a significant improvement for the high-altitude and long-distance trajectory.The trajectory become straight.This optimization method is easily realized in engineering.


From the Congress of Vienna in 1815 until the Treaty of Versailles in 1919, the whole territory formed part of Prussia, and subsequently Germany, and was almost entirely populated by Germans. At the conclusion of the First World War, as is well known, one of the most vexed issues facing the Peace Conference in 1919 was the future status of Danzig; although its inhabitants were largely German, the delegates representing the new State of Poland regarded it as essential that it should have access to the sea through Danzig. The eventual solution was to establish a Free City, with a High Commissioner appointed by the League of Nations.' In a similar vein, Memel was the port through which a very large proportion of the trade of the newly independent State of Lithuania was borne; under the Treaty of Versailles Germany renounced its rights and title over Memel in favour of the "Principal Allied and Associated Powers" (i.e. France, the British Empire, Italy and Japan). Memel was occupied by a French garrison, but in 1923 it was invaded by Lithuania. The Principal Allied and Associated Powers accepted the fail accompli, and in 1924 Memel was ceded to Lithuania under a Convention to which was annexed a statute guaranteeing the city a large degree of autonomy; Article 15 of the Convention expressly stated that "rights of sovereignty over the Memel Territory or the exercise of such rights may not be transferred without the consent of the High Contracting Parties". Under the Treaty of Versailles the boundary between Germany and Poland was defined in such a way that East Prussia remained part of Germany; however.


Linear motor system is used widely for manufacturing automation systems, which provide precision and high speed motion. One type of linear motor systems is Linear DC solenoid motor (LDSM) that is used in this paper. Though LDSM is able to provide instance response, LDSM has not been used widely for servo system due to nonlinear characteristic on real implementation and its stroke too short. However, LDSM used in this paper has better thrust constant compared with general LDSM. Here, the servo system based on LDSM is developed. Firstly, LDSM is employed for position control within disturbance observer. Later, a force control is developed as well. Experimental results shown that LDSM's performance has attained high speed and high precision on both control schemes.


A wide variety of functions either comprise or interface with a Production Planning and Control (PPC) system. Some place demands on the system; some place constraints; some produce the the action; some monitor events and may initiate corrective demands; some monitor passively in order to compile records. Such a wide spectrum of interests normally results in conflicting demands being made on the PPC system, the satisfactory resolution of such conflicts and the design of an efficient system is at the same time difficult and vitally important.

This paper represents an attempt to clarify the scope of a normal PPC system, to structure its tasks and objectives, to outline the interfaces with other functions and activities, to to discuss some of the more obvious problems and to suggest the need for, and form of, some standards.


Plethora of Secretory Amyloids Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson's disease, and type II diabetes. In addition, a few functional amyloid systems are known: the prions of fungi, the bacterial protein curli, the protein of chorion of the eggshell of silkworm, and the amyloid protein Pmel-17 involved in mammalian skin pigmentation. Now Maji et al. (p. 328, published online 18 June) propose that endocrine hormone peptides and proteins are stored in an amyloid-like state in secretory granules. Thus, the amyloid fold may represent a fundamental, ancient, and evolutionarily conserved protein structural motif that is capable of performing a wide variety of functions contributing to normal cell and tissue physiology. Peptide and protein hormones are stored in secretory granules in a nonpathological amyloid conformation. Amyloids are highly organized cross–β-sheet–rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross–β-sheet–rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.


Abstract : The long-term goal is to determine the seasonal reversal South China Sea - Indonesian Seas Transport/Exchange (SITE) flow and its influence to primary Indonesian throughflow (ITF) and dynamics of South China Sea. The main objectives are (1) to measure the magnitude and its variability of the water mass transport/exchange between the Indonesian Seas and South China Sea (SCS) in the Karimata Strait; (2) to determine the effects of this flow and property flux from the tidal to seasonal variability on the circulation and mesoscale dynamics in the internal Indonesian Seas and the South China Sea.


PURPOSE: A rivastigmine containing patch is provided to enhance stability and to express optimal emission pattern. CONSTITUTION: A rivastigmine containing patch comprises rivastigmine free base, a copolymer including butyl methacrylate and methylmethacrylate; and drug adhesive layer manufactured by using adhesive, and double layer of skin adhesive layer which includes silicon gluing agent. As adhesive of the drug adhesive layer, 58-66 parts by weight of 2- ethylhexylacrylat, 28-36 parts by weight of random copolymer and a random copolymer of 4-8 parts by weight of acrylic acid are used. The DURO-TAK™ 87-235A (henkel corp) is used as the adhesive of the drug adhesive layer. The copolymer of the methylmethacrylate and butyl methacrylate is the random copolymer of the methylmethacrylate and butyl methacrylate, and has the weight-average molecular weight of 130,000-170,000 g/mol.


This article examines two approaches to teaching content area literacy: a strategies approach focused on general practices of reading and writing and a disciplinary approach attuned to the particular discourses of particular domains. Basil Bernstein's theory of the pedagogic device is used to critique both approaches' assumptions about content area literacy. Neither approach, it is argued, accounts for the ways content areas bring together discourses from multiple fields. The strategies approach, for instance, does not account for the ways literacies in different content areas are bound up with different discourses. The disciplinary approach, on the other hand, conflates content area discourses with university and professional discourses. At the same time, the disciplinary approach minimizes content area discourses' connections to the discourses of domains such as the public sphere and everyday life. At the end of the article, Bernstein's ideas are used to formulate questions content area teachers might consider when teaching different ways of reading, writing, speaking, thinking, and listening.


In this work, asymptotic and oscillatory behaviour of the solutions of a class of nonlinear second-order neutral delay dierential equations of the form (E1) (r(t)(x(t) + p(t)x(t- r ))')' + q(t)H(x(t- σ )) = f(t) and (E2) (r(t)(x(t) + p(t)x(t- r ))')' + q(t)H(x(t-σ)) = 0 are studied under various ranges of p(t). Sucient conditions are obtained for existence of bounded positive solutions of (E1)


In this paper, we study the reconfigurable intelligent surface (RIS) based downlink multi-user system where a multi-antenna base station (BS) sends signals to various users assisted by the RIS reflecting the incident signals of the BS towards the users. Unlike most existing works, we consider the practical case where only the large-scale fading gain is required at the BS and a limited number of phase shifts can be realized by the finite-sized RIS. To maximize the sum rate, we propose a hybrid beamforming scheme where the continuous digital beamforming and discrete RIS-based analog beamforming are performed at the BS and the RIS, respectively. An iterative algorithm is designed for beamforming and theoretical analysis is provided to evaluate how the size of RIS influences the achievable rate. Simulation results show that the RIS-based system can achieve a good sum-rate performance by setting a reasonable size of RIS and a small number of discrete phase shifts.


the monitoring of active HHV-6 infection after SCT. First, HHV-6 is known to be latent in lymphocytes. For example, in patients with exanthema subitum, HHV-6 DNA is detectable in peripheral blood mononuclear cells (PBMCs) during and after the disease and is found in plasma only during the acute phase [7], which suggests that HHV6 DNA in plasma, but not in PBMCs, correlates well with systemic replication during the acute phase. If reverse-transcription PCR is not performed, false-positive PCR detection can occur in samples that contain PBMCs. Even in the setting of quantitative PCR, a cutoff point to distinguish active HHV-6 infection from latent infection has not yet been identified. Second, the predilection period of HHV6 reactivation after SCT differs substantially from that of HCMV. In our analysis [6], 3 of 24 positive subjects were positive for HHV-6 DNA before engraftment, and 17 became positive on days 0–9 after engraftment. Leukocyte counts in peripheral blood during this period are low. HHV-6 DNA loads in WB would thus be negatively biased if few leukocytes are available. Third, the most important issue raised was that polymorphonuclear leukocytes provide a major contribution to the HHV6 load in WB. However, the potential range of cellular hosts for HHV-6 is wide. Drobyski et al. [9] reported fatal HHV-6 encephalitis in an SCT recipient, and the results of a post mortem examination of the brain showed that most HHV-6–infected cells in the white-matter lesion were astrocytes. In our study, the development of neurological symptoms corresponded precisely with peak plasma HHV-6 DNA loads in all 4 patients who developed limbic encephalitis. This important finding suggests that plasma levels of HHV-6 DNA in these patients reflected viral replication in the brain. We believe that the most serious HHV-6–associated complication in SCT is encephalitis, and the most important role of monitoring of HHV-6 is in the diagnosis (or prediction) of such complications earlier and more accurately. In cases where HHV-6 infects the brain, the HHV-6 load in WB, if it mainly reflects the viral load in polymorphonuclear leukocytes, may not correlate with HHV-6 replication in the brain. Achour et al. [1] also raise the point that the presence of HHV-6 DNA in plasma mainly results from the passive lysis of infected blood cells. Although we were unable to discuss this issue because no associated data were presented in their article, we are making an effort to inhibit the degradation of leukocytes as much as possible in our laboratory. We agree that every effort must be made to establish promising approaches for monitoring HHV-6 infection in immunocompromised patients. The only suitable approach for solving these questions involves clinical studies to compare the abilities of WB and plasma to specifically and accurately detect HHV-6 infection as early as possible, particularly in HHV-6–associated encephalitis.


The function of nano titanium dioxide (TiO_2) powder has determined the high additional value of product, and function depends on particle size and crystal form.The goal of calcination is to make it dehydrate and desulfurize under high temperature and form nano-TiO_2 of some kind of crystal form and granularity index in commercial production of nano -TiO_2.Some calcinations methods including spray drying,rotary dryer and dynamic rotating flow calcinator-spin flash dry- er are discussed,such as production characteristic,crystal form,the appropriate scale and existing problems.


CaM BP-10 (BP-10) is anovel endogenous calmodalin (CaM )-binding Protein tha was observed in andisolated from Plant. In our prelidrimpstudies it has been shown tha BP-10specifically inhibits adrin (IAA)-in-duced coleoptile elongallon and pbonsecrehon. In oIder to inveshgatewhether BP10 inhibitS Picton secrehonand cell elongaion thidgh inhibitingthc achvity of Plasrna mernbare (PM)H+ -ATPase, the effect of BP-10 on theachvity of wheat coleoptile PM H+ -AT-Pase has been studied. It was observedtha neither IAA nor BP-10 had any effect on the achvity of PM H+ -ATPaSein vitro. In vho, however, the activity0f Al-treated PM H+-ATPaSe washigher than tha of the control, and BP-10 peilicanx iwhbital atinduedachvity by 87- 8% (rig. 1) - In addi-hon, the inhibitory effect cotild be re-versed by IAA after BPIO was removedfrom the mediurn, and it could also beovercome bV the addihon of CaM.Therefore, it appears that BP-10 in-hibits cell responses to andn by affect-ing the achvity of PM H+ -ATPase andthereby inhibiting Proton secrehon. As aresult, cell elongaon is inhibited. AndCaM is also involved in this pmeess-


Soil pollution is a highlighted concern of modern society, particularly in developing countries. The Drosh-Shishi valley, which is a hilly region near Afghanistan with a land area of around 15,000 km2, is situated in the south of Chitral District (Pakistan) and has a population of approximately 450,000. Nowadays, this region is being explored for soil pollution, specifically heavy metals which pose a potential risk to human health. Therefore, our main goal was to investigate possible sources of heavy metals' spread and to assess the content levels in soil and the associated risks for human. We collected 34 representative samples from transported sediments and 31 from agricultural crops. We analyzed the soil samples for the contents of Cd, Co, Cr, Cu, Mn, Ni, Pb, and Zn using ICP-OES analyzers. These values were used to obtain the contamination factor (CF) and to estimate the potential health risk caused by heavy metals according to the USEPA dose–response model. Our results suggest that the heavy metal pollution has a geogenic source, but it is also aggregated by chemical fertilizers used in farming. Regarding levels, most of the metals except Pb showed contents above the permissible level, with CF values from moderate to high. Overall, Cu and Ni showed a significant total cancer risk (TCR > 1 × 10−4) in children. Therefore, we conclude that heavy metal pollution is causing a serious threat to humans in this area, and we recommend that authorities should make more efforts in monitoring the heavy metals content in soils to reduce potential health risks.


To eliminate Chinese national crisis depends on the establishment of advanced theory.In the period of Democratic Revolution of the old Type,our attempts to explore advanced theory failed.Then Chinese Commmunist Pa rty combines Marxism Leninism wity the practical situation of China,established Mao Zedong Thoughe standing for the proceeding direction of Chinese Advanced cul ture and succeeded in New Democratic Revolution ,So,to seek aduanced theory has become the hictorical gist from the modern times to the foundation of our people 's Republic.


from, this the most disquieting of all guests?" Introduced by Wittgenstein, Nietzsche, and Freud1 under a theory of events that string together like a heraldic scroll psychic, historical, ontological, and epochal, something (but what?) or someone (but who?) is arriving in the sanatorium dining room at Davos and is making the young Hans Castorp jump.2 What? Who? the anti-hero of Thomas Mann's Der Zauberberg (1924) keeps on asking himself. And he does so because he has, in fact and in principle, not witnessed that which suddenly happened and so completely upset him: something, or someone (but who, and what?) has in fact slammed a door shut to the left? there, on the side of the dying west. Something has occurred for sure, but it is perceptible only through the signs it left in its passing, through its secondary minor qualities, for the effects it produces that do not exist without it. A happening takes place, but it can be said to exist only in its indexicality, for its power (like a verb form) to act?cause, become, make an impression, and demand attention?after it is realized.3 After it has crossed the threshold, gone beyond the limit that both separates and brings together different spaces and times, and has passed the topological string that ties places and stories, drawing them together from inside and outside into a symbolic ribbon. Out of respect for a hospitality regulation, which prescribes an inversion between active and passive, guest and host, relative and stranger and among past, present, and future, something (or someone) nameless?an event or process present through its being experienced, not, so to speak, in person, but in allen Anzeichen.4 Not a presence, not a chronological or experienced present?but the mere dispersion of signs and symptoms in all directions, like the scattering of the marginal characteristics of a substance that cannot be found, subject only to a retrospective story. And, for me, it is precisely around this center of attraction and affection that the relationship between memory, literature, and visual arts in Mann's text is organized.


AVS-M is a video compression standards which has independent intellectual property rights and good compressive property. DM642 is a special digital signal processing chip facing multimedia applications, provided by TI Company. It has best video handling ability, and it is a platform of DSP realization of AVS-M. The methods of realizing AVS-M real time encoding by kinds of optimiza-tion techniques are discussed and the experimental results are given out in this thesis.


Pharyngocutaneous fistula is one of the most common wound complications after total laryngectomy. The leakage of saliva may cause an erosion of...


AIMS
A report of a systematic review of reviews which examines the impact of having midwives-led maternity care for low-risk women, rather than physicians.

BACKGROUND
  A rising birth rate, increasing complexity of births, and economic constraints pose difficulties for maternity services in the UK. Evidence about the most effective, cost-effective, and efficient ways to give maternity services is needed.

DATA SOURCES
  Searches were carried out in August-September 2009 of ten electronic databases, 16 key nursing and research websites, and reference lists of 56 relevant reviews. We also contacted 38 experts for information. No date restrictions were employed.

REVIEW METHODS
  A narrative review of systematic reviews or 'meta review' was conducted using transparent and systematic procedures to limit bias at all stages. Systematic reviews that compared midwife-led care during pregnancy and birth with physician-led care were eligible for inclusion.

RESULTS
  Three meta-analytic reviews were included. Midwife-led care for low-risk women was found to be better for a range of maternal outcomes, reduced the number of procedures in labour, and increased satisfaction with care. For some maternal, foetal, and neonatal outcomes reviews found no evidence that care led by midwives is different to that led by physicians. No adverse outcomes associated with midwife-led care were identified.

CONCLUSIONS
  For low-risk women, health and other benefits can result from having their maternity care led by midwives rather than physicians. Moreover, there appear to be no negative impacts on mothers and infants receiving midwife-led care.


An insulation structure provided among a plurality of electrodes for extraction of an ion beam from a plasma generating section is provided. The insulation structure includes an insulation member including a first part connected to a first electrode and a second part connected to a second electrode and configured to support the first electrode to the second electrode, a first cover surrounding at least a part of the first part to protect the first part from contamination particles, and a second cover surrounding at least a part of the second part to protect the second part from contamination particles. At least one of the first part and the second part is made of a machinable ceramic or a porous ceramic.


In the batch of Lactobacillus planturam,the Lactobacillus planturam's acid tolerability could be greatly enhanced in the presence of 50 mmol/L acetic acid or 10 mmol/L propionic acid or 20 mmol/L n-butyric acid or 50 mmol/L potassium acetate or 2 mmol/L potassium citrate,and the cell survival improved 80-fold in the condition of pH 2,37 ℃ and 90 min compared with the control,especially in acetic acid,potassium acetate and n-butyric acid.However,potassium tripolyphosphate had a little effect on the Lactobacillus planturam's acid tolerability.


A field experiment was conducted at KVK, Srinagar during Kharif seasons of 2008-09 and 2009-10 to study the "Combined effect of organic and inorganic sources on growth and yield of Soybean (Glycine max (L.) Merill) in temperate Kashmir". The experiment was laid out with 18 treatment combinations viz., three levels of each of recommended doses of inorganic fertilizers (50, 75 and 100% RD) and organic manures (control, FYM 10 t ha -1 and Dalweed 10 t ha -1 ) and two levels of biofertilizers (control and dual inoculation with Rhizobium + PSB) in randomised complete block design with three replications. The results revealed that grain and straw yield increased significantly with increase in the recommended inorganic levels. Application of FYM @ 10 t ha -1 showed significantly superior results over other organic treatments. Dual inoculation with Rhizobium and PSB showed significantly superior results over no inoculation. Yield attributing characters viz. 100-seed weight and number of nodules showed significant increase with increasing levels of recommended inorganic fertilizers. Application of 75% recommended inorganic fertilizer level showed highest 100-seed weight over other levels. Among organics, FYM (10 t ha -1 ) was found superior over Dalweed (10 t ha -1 ) for yield attributes. Oil and lysine content was found superior with application of 75% recommended inorganic fertilizers over other levels, Protein content increased with increasing levels of recommended inorganic fertilizers. Among organics FYM (10 t ha -1 ) yielded significantly superior results for seed quality than dalweed (10 t ha -1 ).


Frank A. Oski, Walter W. Tunnessen, and Catherine Caldwell Brown are remembered by a colleague for their inestimable contribution to this publication.


In order to study influence of freezing rates on the qualities of Rachycentron Canadum fillets,the change on physicochemical and texture profile characteristics,sensory quality of Rachycentron Canadum fillets frozen by three different freezing rates(2.08,1.22,0.35 cm·h~(-1)) and stored at-20±1℃ were studied.Results indicated that the freezing point of Rachycentron Canadum fillets was-1.9±0.2 ℃.With the increasing of freezing rates,the drip loss after thawing,salt-soluble protein content loss and Ca~(2+)-ATPase activity loss rate decrease markedly in the frozen storage(P0.05),but no significant change on the moisture loss.The hardness and chewiness of Rachycentron Canadum fillets frozen by different freezing rates increased greatly(P0.05) while the recoverability decreased during frozen storage.Different freezing rates remarkably influenced on the flavor and texture less affected on color of raw or cooked Rachycentron Canadum fillets.Different freezing rates also leads to significant difference on texture and sensory during frozen storage.The organoleptic quality of the fillets by quick-freezing is better than those by slow-freezing.It can be concluded that increasing the freezing rates will help to maintain the original qualities of Rachycentron canadum fillets.


This paper discusses the problem of improving the realism of motion not from the joint point-of-view as for robots, but in relation to the deformations of human bodies during animation. Two methods for improving these deformations are described. The Joint-dependent Local Deformation (JLD) approach is convenient when there is no contact between the human being and the environment. A finite element method is used to model the deformations of human flesh due to flexion of members and/or contact with objects.


Although humans spend a third of life asleep, the function this sleep serves is still unknown. Using the model system Drosophila melanogaster, we have begun to identify genes that alter either sleep or sleep homeostasis, the increase in sleep observed after sleep loss. One of the genes we have identified, extra‐cellular signal regulated kinase (ERK), is of particular interest given its role in synaptic plasticity. Thus, we expressed an activated form of ERK (UAS‐ERKact) in adult flies using the pan neuronal Geneswitch driver Gsw‐elav. We have found that RU486 (RU) fed GSw‐elav/+>UAS‐ERKact/+ display a significant increase in sleep compared to vehicle (ETOH) fed controls. Importantly, the pan neuronal expression of ERKact in the adult fly also results in a significantly larger sleep rebound than controls. Consistent with these results, we have observed a reduction in sleep time and an attenuated sleep rebound in two loss of function lines for the Drosophila homologue of ERK, rolled (rl1) and GSw‐elav/+>rlRNAi. Surprisingly, no sleep rebound is observed when ERKact is expressed in the adult Mushroom Body (MB) indicating that ERKact plays a circuit dependent role in sleep regulation. Given the relationship between sleep and synaptic plasticity, it will be interesting to further elucidate the common signaling cascades linking ERK, sleep and plasticity.


Part One The beginnings to 1700: differentiation and standardization in early Scots, Anelli Meurman-Solin the origins of the Scots orthography, Veronica Kniezsca the phonology older scots, Adam J. Aitken the morphology of older Scots, Anne King the syntax of older Scots, Lilo Moessner the lexis of older Scots, C.I. Macafee older Scots phonology and its regional variation, Paul Johnston older Scots literary language, Ronald D.S. Jack. Part Two 1700 to the present day: phonology of Scots post 1700, Charles Jones syntax and morphology - 1700 to the present day, Joan Beal Scots lexis post 1700, Graham Tulloch regional variation in Scots post 1700, Paul Johnston ongoing change in modern Scots - the social dimension, C.I. Macafee. Part Three Scots overseas: Scots in Ulster and North America, Michael Montgomery Scots in Australia, Graham Tulloch Gaelic influence, Colm O'Baoill.