The mainstream of children's films in "the Seventeen Years" embraces political education.There are also some fairytale films and comedy in this period.At the edge of political narration,these films pay attention to the fantasy and entertainment factors,reflecting children's real life and disposition.They are more close to the noumenon of children's films and enrich the ideological appeal and artistic forms of Chinese children's films.However,they inevitably have the deficiency of the times.With the aim of education,they can't be truly free and relaxed,which is the problem of today's children's films.


Recent advances in networks, information and computation grids, and WWW have resulted in the proliferation of a multitude of physically distributed and autonomously developed Web services. This second part presents two key scenarios in B2B and B2C, the central function of services composition and orchestration, the languages and prominent technologies and lastly an industry and research roadmap.


The utility model relates to an electric vehicle battery system with an electricity utilization metering function. Battery output current detected by a battery output current detection circuit and battery voltage detected by a battery voltage detection circuit are sent to a battery electricity utilization operational circuit simultaneously, instant power is generated by the battery electricity utilization operational circuit according to current and voltage operation, actual electrical utilization information is generated according to time integral, and then the actual electricity utilization information is recorded and stored in a battery electricity utilization storage unit. By aid of the electric vehicle battery system with an electricity utilization metering function, battery actual output electricity can be obtained and extracted by a communication interface or via a directly display form, and can be used as a basis of charge for replacing batteries so as to enable charge to be more scientific and reasonable. The electric vehicle battery system with an electricity utilization metering function is particularly adaptable to an electric supply mode of electric vehicle with replaceable batteries.


In cis-[PtCl 2 (C 18 H 9 F 6 O 3 P)(C 6 H 15 P)], the Pt-P and Pt-Cl distances are comparable to those of the triphenylphosphite analogue, while the P-Pt-P angle is ca 5° larger.


Abstract : The Standard for the Exchange of Product Model Data (STEP) is being developed as an international standard. The National PDES Testbed was established at NIST specifically to address the development and testing of STEP, and to serve U.S. industry in its use of the standard. An Application Protocol (AP) is a specification for a subset of STEP data that can be implemented in an application system. The Application Protocols for Mechanical Parts Production effort will produce an early example of APs being used together in an operational prototype. This effort will develop, fully test, validate, and deliver a set of Application Protocols to the STEP Production Cell application systems which support the following: detailed design, process planning, and numerical control programming. This document describes the plan for developing and validating a series of three application protocols required as input to the STEP Production Cell. The resultant candidate APs, that will be submitted to ISO for inclusion in the standard, will have been validated and thoroughly tested prior to their submission.... Application protocol, Mechanical parts production, National PDES testbed, PDES, STEP, STEP Production cell, Validation testing system.


The National Army of Colombia is an institution that functions as a business organization, there are labor relations, hierarchies, headquarters, subordination, so problematic situations arising from such relationships, one is bullying are also presented.
However, it is not well received is also in a military institution whose features make the command line is not refuted, orders must be met, feeling in the air certain submission to the abuse of power.


(90), of the Chalcidian League (90-91) and of Syracuse (100-102) are offered as if practically certain. This is a great pity, as W. does make some important and legitimate points in these sections, but his failure to distinguish between what is certain, what is probable, and what is possible, leaves the reader at a loss as to what to accept and what to leave to one side. Finally, negligent editing has resulted in the inclusion of a number of irritating typographical errors. Thus 'Campanian' for 'Companion' cavalry consistently (155-65, 214-17), and 'Spartulos' (90-92) alongside' Spartolus' (92). Greek terms, too, are sometimes irregularly or inaccurately transcribed; thus hamippe for hamippos (62), estasis for hestiasis (72), and anthippasis for anthippasia (81).


The paper examines the use of NSF's Collaborative Infrastructure and the Convergence Research approach for complex social innovation challenges used by the authors in their NSF INCLUDES project (#1744490). The paper clarified terminologies related to Convergence Research for multi-, co- inter- and trans-disciplinary. This paper defines and describe collaborative research at each of these interfaces. Then it discussed key factors for engaging in collaborative partnerships as individuals, with teams, and as organizations. Then, it presented concepts tied to individual factors for engagement with the attitude, investment, motivation, and scenario analysis method. Next, by drawing on business and management research, the Availability, Interest, and Knowledge methodology provided a simple way to identify the alignment of the vision, mission, and theory of change by understanding the why, what, and how of your actions. Following this, the authors integrated the concepts of strategic planning and logic models with the Universal Model of Strategic Planning. The authors discuss the double diamond model to represent the complex web of partnerships and the framework developed for communication and collaboration amongst stakeholders. The result is the Collaborative Convergence Pyramid framework for negotiating understanding within a new common space being generated together. Finally, the work concluded with a discussion of the vital roles collaborative infrastructure and strategic planning played in facilitating the Convergence Research approach with a multi-stakeholder coalition.


An experiment was conducted to examine the effects on mortality, production performance, water intake (WI) and organ weight of Satureja khuzistanica essential oil (SkEO) using 720 one-day-old Arian broiler chicks in a 42-day trial. Experimental treatments were addition of 0 (control−), 200, 300, 400 and 500 mg/L SkEO or 500 mg/L polysorbate-80 (control+) into drinking water. The birds were kept under natural ambient temperatures 4–6°C above standard recommendation from days 22 to 42 of age. Addition of SkEO into drinking water at 200 and 500 mg/L decreased weight gain (P < 0.05) of the birds from days 29 to 35 of age with no differences in feed intake (FI) and feed conversion ratio (FCR) compared to control groups (P > 0.05). Addition of 300 and 500 mg/L SkEO into water increased mortality rate of the birds mainly from days 29 to 42 of age. The calculated European broiler index was greater for the birds receiving drinking water supplemented with 400 mg/L of SkEO compared with the other birds. In conclusion, administration of SkEO at 400 mg/L through drinking water to heat stressed broiler chickens may result in improved production performance efficiency.


Objective: To investigate the perceptions of senior psychiatric trainees regarding the extent and satisfaction of the teaching during psychiatric training of five different psychotherapies, namely cognitive behavioural therapy (CBT), dynamic therapy, family therapy, group therapy and supportive therapy. Method: A 60-item questionnaire was completed by 95 senior psychiatric trainees in Australia and New Zealand. This questionnaire used Likert scales to examine the degree of satisfaction in the quality of teaching received in the five psychotherapies. The teaching mostly consisted of seminars and supervision. Qualitative responses were also sought regarding the experience of teaching and suggestions for improvement. Results: Satisfaction rates in the quality of teaching varied from 7 to 41% and in the extent of teaching ranged from 4 to 20%. Trainees wished for more training in CBT, group, family and supportive therapies, practical seminars, and better supervision. Conclusions: Psychiatric trainees view the extent and quality of teaching in the psychotherapies as being deficient. Implications of these findings are discussed.


In this paper we describe a top down nano-fabrication method to make single-digit nanoholes that we aim to use for DNA and RNA characterization. There are three major steps towards the fabrication of a single-digit nanohole. 1) Preparing the freestanding thin film by epitaxial deposition and electrochemical etching. 2) Making sub-micro holes (0.2 μm to 0.02μm) by focused ion beam (FIB), electron beam (EB), atomic force microscope (AFM), or other methods. 3) Reducing the hole to less than 10 nm by epitaxial deposition, FIB or EB induced deposition. One specific aim for this paper is to model, simulate and control the focused ion beam machining process to fabricate holes which can reach single-digit nanometer scale on solid-state thin films. Preliminary work has been done on the thin film (30 nm in thickness) preparation, sub-micron hole fabrication, and ion beam induced deposition, and results are presented.Copyright © 2008 by ASME


Introduction: The initial response to standard induction chemotherapy for acute myeloid leukemia (AML) is commonly assessed with day 14 bone marrow evaluation; patients with residual disease may receive re-induction chemotherapy. The benefit of re-induction chemotherapy in patients with indeterminate day 14 bone marrow results (defined in our study as ≤ 20% cellularity and 5-20% blasts) remains unclear. We report our experience of AML patients with indeterminate day 14 bone marrow treated with and without re-induction chemotherapy.
 Methods: A retrospective chart review was performed to evaluate adult patients with newly diagnosed AML treated with and without re-induction chemotherapy for indeterminate day 14 bone marrow results between January 2010 and April 2018 at our institution. All patients included in the analysis received induction chemotherapy with cytarabine and an anthracycline. Approval for the study was obtained from the Institutional Review Board.
 Results: We identified 50 patients with indeterminate day 14 bone marrow results (Table 1). Twenty five patients (50%) received re-induction therapy and 25 (50%) did not. Flow cytometry data on day 14 bone marrow samples were available for 15 patients (60%) who received re-induction and 18 (72%) who did not. All flow cytometry samples, when performed, were reported as persistent/residual disease. The median age at diagnosis was 56 years (range 19-70) in patients who received re-induction and 59 years (range 23-73) in those who did not. There were 12 patients (48%) with poor risk disease, both in the re-induction arm (10 abnormal karyotype, 2 normal karyotype with molecular abnormalities) as well as in the no re-induction arm (6 abnormal karyotype, 6 normal karyotype with molecular abnormalities). FLT3-ITD mutation was positive at diagnosis in 2 cases (8%) in the re-induction arm and in 8 cases (32%) not receiving re-induction. The most commonly used chemotherapy regimen in the re-induction arm was fludarabine, high dose cytarabine and granulocyte-colony stimulating factor (FLAG, 56%). Fifteen patients (60%) in the re-induction arm and 17 (68%) in the no re-induction arm received post-remission consolidation therapy. High-dose cytarabine was the preferred consolidation regimen (96%).
 The overall response rate [complete remission (CR) + CR with incomplete count recovery (CRi)] was similar in both arms (80% vs. 80%). There was no statistically significant difference in median overall survival (OS) and relapse free survival (RFS) between the re-induction and no re-induction arms (Figure 1). In univariate analysis, no statistically significant difference in OS was found for age at diagnosis (≥ 60 years vs. < 60 years; p=0.06), white blood cell count at diagnosis (≥ 50,000 vs. < 50,000; p=0.48), disease risk status (poor risk vs. favorable/intermediate risk; p=0.81) and performance of transplant (yes vs. no; p=0.13) in the entire population.
 Conclusion: Our study did not find a statistically significant difference in overall response rates, as well as for OS and RFS in AML patients with indeterminate day 14 bone marrow receiving re-induction or not. Our findings question the utility of immediate re-induction chemotherapy and raise the concern for over treatment in this patient population. Larger studies investigating similar outcomes are warranted to validate these clinical findings.
 Table 1. Table 1.

 Costa: Celgene: Honoraria, Research Funding; Abbvie: Research Funding; Amgen: Honoraria, Research Funding; Janssen: Research Funding; Karyopharm: Research Funding; Sanofi: Honoraria; BMS: Research Funding. Saad:Actinium: Consultancy. Papadantonakis:Agios pharmaceuticals: Honoraria, Other: advisory board. Erba:Janssen: Research Funding; Daiichi Sankyo: Consultancy, Research Funding; MacroGenics: Consultancy; Daiichi Sankyo: Consultancy, Research Funding; Incyte: Consultancy, Speakers Bureau; Juno: Research Funding; Amgen: Research Funding; Glycomimetics: Consultancy, Other: Chair, Data and Safety Monitoring Committee; Glycomimetics: Consultancy, Other: Chair, Data and Safety Monitoring Committee; Daiichi Sankyo: Consultancy, Research Funding; Agios: Consultancy, Speakers Bureau; Seattle Genetics: Consultancy, Research Funding; Astellas: Research Funding; Takeda/Millenium: Research Funding; Janssen: Research Funding; Celgene: Consultancy, Speakers Bureau; Novartis: Consultancy, Speakers Bureau; Juno: Research Funding; Amgen: Research Funding; Immunogen: Consultancy, Research Funding; Glycomimetics: Consultancy, Other: Chair, Data and Safety Monitoring Committee; Celgene: Consultancy, Speakers Bureau; Daiichi Sankyo: Consultancy, Research Funding; Seattle Genetics: Consultancy, Research Funding; Pfizer: Consultancy, Other: grant; Astellas: Research Funding; Agios: Consultancy, Speakers Bureau; MacroGenics: Consultancy; Immunogen: Consultancy, Research Funding; Juno: Research Funding; Celgene: Consultancy, Speakers Bureau; Novartis: Consultancy, Speakers Bureau; Takeda/Millenium: Research Funding; Astellas: Research Funding; Glycomimetics: Consultancy, Other: Chair, Data and Safety Monitoring Committee; Takeda/Millenium: Research Funding; Amgen: Research Funding; Amgen: Research Funding; Novartis: Consultancy, Speakers Bureau; Janssen: Research Funding; Jazz: Consultancy, Speakers Bureau; Seattle Genetics: Consultancy, Research Funding; Seattle Genetics: Consultancy, Research Funding; Takeda/Millenium: Research Funding; Janssen: Research Funding; Immunogen: Consultancy, Research Funding; MacroGenics: Consultancy; Pfizer: Consultancy, Other: grant; Agios: Consultancy, Speakers Bureau; Juno: Research Funding; MacroGenics: Consultancy; Incyte: Consultancy, Speakers Bureau; Novartis: Consultancy, Speakers Bureau; Pfizer: Consultancy, Other: grant; Celgene: Consultancy, Speakers Bureau; Agios: Consultancy, Speakers Bureau; Pfizer: Consultancy, Other: grant; Jazz: Consultancy, Speakers Bureau; Jazz: Consultancy, Speakers Bureau; Immunogen: Consultancy, Research Funding; Astellas: Research Funding; Incyte: Consultancy, Speakers Bureau; Incyte: Consultancy, Speakers Bureau; Jazz: Consultancy, Speakers Bureau.


Cystic fibrosis (CF) is a recessive genetic disease caused by a mutation in the cystic fibrosis transmembrane regulator (CFTR) gene. One of the consequences of a dysfunctional CFTR protein is impaired mucocillary clearance, which allows the colonisation of microbial pathogens in the lung. The CF lung is colonised predominately by bacteria; with Burkholderia cepacia complex, Pseudomonas aeruginosa and Staphylococcus aureus being the most important pathogens. Pseudomonas aeruginosa, a Gram-negative bacterium, has the highest prevalence of these bacteria, occurring in up to 80% of adults infected with CF. During CF lung infection this bacterium will undergo phenotypic and genotypic adaptations allowing its persistence. The Burkholderia cepacia complex, the second most significant Gram-negative bacteria in the CF lung, is a lot less widespread than P. aeruginosa. However, this does not diminish the importance of the B. cepacia complex; as it is often associated with poor prognosis and can be transmitted from patient to patient. While the B. cepacia complex and P. aeruginosa are arguably the most important Gram-negative pathogens in CF, various other Gram-negative bacteria have been isolated from the CF lung but their role in infection has not been clarified.


A semiconductor integrated circuit, a booster circuit and a capacitor, a parasitic capacitance may prevent characteristic degradation of the capacitor due to the surrounding generated. Constitute the capacitor (532) using a well boosting circuit capacitor. Further, as to cover the gate electrode (23) formed of n-type well (21) of the first wiring layer (26) for a portion of the capacitor voltage is applied to the well.


Feng Yuxiang holds Wuyuan Rally to pledge resolution and joins the Nationalist Party, of which the external cause is the Nationalist Party and the Communist Party's long term work to win him over, as well as the Soviet Union's aid, while the internal cause is his own progressive ideology.


Although the work of Cushing and Spillcr and Frazier has bmugl~t cerebral dccompression more promiuently before the profession in the past fe\r years, it is not a new operation. r\nnandalc reported, in 1894, that he had operated about IS70 on a patient with sjmptoms of pressure, without finding any special lesion, wit11 relief of tlie pressure symptoms. I le stated that Lister had operated successfully on a similar case. He trephined a casc in 1859 with severe headaches follo\ving an injury years before, with a perfect cure. IIe says the operation relieves the pressure and it1 some instances the growth shrinks or degenerates. AIacewen, in 1889, trephined a case of tubercle of the cerebellum with instant relief to the patient, and removed the growth a \vcek later. Sahli, in 1891, reported some work along these lines, with marked improvcnient in the condition of t11e.patients. H e prefers several small trephine openings to one large one. White reported a number of cases of cpiIepsy, the same year, that were very much improved by decompressive oper8tions, although no lesion of the brain \vas found. Horsley reported cases, in ISI)~, relieved of the heaclaches and nausca vith subsidence of tlie s\vclling of the optic discs. One case lived IS months and another for 2 years with coinparative comfort. IIc has noticed that in some cases simple ol~ening of the skull had caused the tumor to rlegcnerate. Jaboulay, in 1893, trephined a casc of tubercle of <he bmin \vitliout opening the dura with good results. Keen, in JS9-7 and IS94 removed a portiou of the skull to relieve severe headachcs with satisfactory results. Putnam said in IS95 that he had seen a patient that had been free of pain for rnany years follon,ing a simple opening of the skull. Ludwig Gruns (1897) says a ; a g e opening should be made in the skull with excision of the dura, \vliich allows the tumor to protrude and remove pressure irom thc lymph vessels of the brain. The g e ~ m a l symptoms disappear quickly, con~ciousuess returns, headache, vomiting and choked discs disappear. Clarke and JIorton (1896) reported a casc that was much benefited by the removal of a large area o i boric without incising thr dura. Alfred \Viener (189s) had a case tcmporarily relieved by trephining and slloning the tumor to bulge through the bone defcct. Babinski reported several cases in 1901 tllat were much improved by operation; the hcadache, vomiting and the choked discs disappearing almost immediately. Leslie Paton collected 30 cases operated on in which vision was saved in 22 and in IS \\.as as good as before operation. I l e advises escision of the dura in all cases. Codman thinks (1905) that for brain tumor, the palliative operation only is justifiable in the Iiauds of the average surgeon. Gushing's papcr, reporting his work on decompression for inoperable tumors, was published in 1905, and for bnrsting fractures of the skull in Nay, 190s. Spiller and Frazier (19CG) report two cases operated on by Keen. One was a man with failing eyesight, severe headaches, vomiting and extensive optic neuritis; an osteoplastic


Both theoretical models of job search and empirical research findings suggest that job search behavior is not a unidimensional construct. This chapter addresses the multidimensionality of job search behavior and provides a systematic review of the different job search behaviors and sources studied in the job search literature and their relationships with antecedent variables and employment outcomes. Organized within three major dimensions (effort-intensity, contentdirection, temporal-persistence), job search effort and intensity, job search strategies, preparatory and active job search behaviors, formal and informal job sources, specific job search behaviors, job search quality, job search dynamics, and job search persistence are discussed. This review strongly suggests that considering all the dimensions of job search behavior is essential for understanding job search success in both practice and research, resulting in a number of key implications for job seekers and employment counselors as well as crucial directions for future research.


Objective To investigate the CT features of primary pulmonary sarcomatoid carcinoma(PSC).Methods CT manifestations of 13 patients with primary PSC confirmed by pathology were reviewed retrospectively.All patients underwent plain CT examinations,while 10 of them also underwent contrast-enhanced CT scan before surgery.Results All lesions were unilateral.Seven lesions located in right lung and 6 lesions occurred in left lung,including 9 were peripheral and 4 central tumors.The lesions appeared regular in 2 cases with well-defined margins,but irregular in 11 cases with ill-defined margins.The mean maximum diameter of the lesions was 4.9 cm(range,3.0 to 8.3 cm).The tumor showed heterogeneous density in all cases.Ten showed irregular peripheral heterogeneous contrast enhancement after injection of contrast media.The center part of the tumor showed no enhancement or inhomogeneous enhancement.Three lesions had thoracic wall or pleural invasion,5 had hilar or mediastinal lymphopathy and 1 had unilateral pleural effusion.Conclusion CT features of primary pulmonary sarcomatoid carcinoma are distinctive in certain extent,but the final diagnosis still depends on histopathological examination.


Firstly,the unsupervised discriminant projection(UDP) criterion is modified.Then,the feature extraction method of the maximum scatter difference based on preserving projection is proposed on the basis of the modified discriminant criterion.The proposed method adopts the difference of both nonlocal scatter and local scatter as discriminant criterion.Thus,the singular problem of local scatter caused by small sample size problem in UDP linear discriminant analysis is avoided.Finally,experimental results on Yale and FERET face databases demonstrate the effectiveness of the proposed method.


The resistive switching properties in amorphous Pr0.67Sr0.33MnO3 films deposited by pulsed laser deposition are investigated.Reproducible and bipolar counter-8-shape and 8-shape switching behaviours of Au/Pr0.67Sr0.33MnO3 /F:SnO2 junctions are obtained at room temperature.Dramatically,the coexistence of two switching polarities could be reversibly adjusted by an applied voltage range.The results allocated those two switching types to areas of different defect densities beneath the same electrode.The migration of oxygen vacancies and the trapping effect of electrons under an applied electric field play an important role.An interface-effect-related resistance switching is proposed in an amorphous Pr0.67Sr0.33MnO3-based memory cell.


The Endangered Species Act (ESA), 16 U.S.C. §§ 1531-43, is the "most comprehensive legislation for the preservation of endangered species ever enacted by any nation." Tennessee Valley Authority v. Hill, 437 U.S. 153, 180 (1978). ESA imposes substantial and continuing obligations on all federal agencies. Despite its importance, little guidance exists for practitioners seeking to represent clients with ESA concerns. For the most part, species are listed as threatened or endangered with little or no input from the private bar. Only in the most visible cases do practitioners become involved in the listing process. Similarly, decisions in the ESA consultation process that may permit development affecting a listed species are often made long before the practitioner is involved. Consequently, the legal procedures for listing an individual species as well as later consultation are not well known.


The invention discloses a three-dimensionally wrapped packaged LED (Light Emitting Diode) chip, which is characterized in that six planes of a vertically packaged or inversely packaged single LED chip or series-parallel connected LED chips are coated with fluorescent powder and are fixed by using transparent materials at the periphery, so as to carry out three-dimensional packaging; or a single LED chip or a plurality of series-parallel connected LED chips adopt a vertical or inverse structure and are put into a spherical or tubular shell made of transparent materials; the LED chips are wrapped three-dimensionally by coating a fluorescent powder layer on the inner wall of the shell or mixing the fluorescent powder into the transparent materials; or the LED chips are firstly wrapped by using transparent materials, and subsequently the fluorescent powder is coated on the transparent materials; or the three-dimensional wrapping is carried out by adding a layer of transparent shell material after the coating of the fluorescent powder so as to protect the fluorescent powder. The chip has the beneficial effects that a simplest fluorescent powder wrapping process is adopted so as the make the LED chip emit light in all directions; and in comparison with a traditional single side light emission mode, the loss on light emission of the LED chip is reduced.


This paper describes a floor-controlled centralized conference system being developed for LARC (Laboratory of Computer Architecture and Network - Escola Politecnica - Engineering School) distance learning tool Floor control was used to regulate interaction and access to the audio channel and to restrict network bandwidth usage. A floor control protocol and a light session protocol were developed. Implementation was made using web technology in order to ease integration with web-based systems. This system runs over IP unicast communication infrastructure. Some experiments were made in order to evaluate the quality of service of a centralized conference system for distance learning. The quality of service parameters evaluated for the conference system user were usability, interactivity, voice subjective quality and bandwidth needed, while the parameters evaluated for the conference system owner were bandwidth, processing costs and system scalability. This paper aims to present the results of such experiments. In the first one, floor control was tested as a mechanism for restricting bandwidth consumption in centralized conferences and the bandwidth needed by the user, by the multipoint control unit (MCU) and by the conference system owner were evaluated. In the second one, delay and packet loss were seen through the use of a real world scenario (remote tests), impacting the voice subjective quality and the interactivity among conference participants. In the last one, a subjective experience reveals information about the usability of the system. These results have taken as basis to improve the current conference system and the modus operandi of the distance learning system as a whole.


Determination of tides using reflected signals is an important aspect of GNSS application technique at the present. For the problem of remote sensing the tide heights, a method of retrieving the height of sea surface is proposed from the power of the interference signals obtained by a coastal GPS receiver with singular antenna. An experiment was carried out at the coast of Qingdao. Results of the receiving antenna height over the sea surface from observed interference signals are presented. Compared to tide gauges, the results show its validity of the method based on GPS interference measurements using right-hand circular polarization antenna.


'Bjerknes Compensation' (BJC) refers to the anti-correlation observed between atmospheric and oceanic heat transport (AHT/OHT) variability, particularly on decadal to longer timescales that may be important to the predictability of the climate system. This study investigates the spread in BJC across fully-coupled simulations of the Coupled Model Intercomparison Project Phase 6 (CMIP6) and critical processes (particularly related to sea ice and clouds) that may contribute to that spread. BJC on decadal to longer timescales is confirmed across all the simulations evaluated, and it is strongest in the northern hemisphere (NH) between 60°N-70°N. At these latitudes BJC appears primarily driven by the exchange of turbulent fluxes (sensible and latent) in the Greenland, Iceland and the Barents Seas. Metrics to break down how sea ice and clouds uniquely modify the radiative balance of the polar atmosphere during anomalous OHT events are presented. These metrics quantify the impacts of sea ice and clouds on surface and top of atmosphere (latent, sensible, longwave and shortwave radiative) energy fluxes. Cloud responses tend to counter the clear sky impacts over the Marginal Ice Zone (MIZ). It is further shown that the degree of BJC present in a simulation at high latitudes is heavily influenced by the sensitivity of the sea ice to OHT, which is most influential over the MIZ. These results are qualitatively robust across models and explain the intermodel spread in NH BJC in the preindustrial control experiment.


The prevalence of Raynaud's syndrome was assessed in 100 consecutive renal allograft recipients treated with cyclosporin monotherapy who were then converted to prednisolone and azathioprine. Prior to transplantation 56% were symptomatic for Raynaud's, following transplantation 36% improved, but with the introduction of cyclosporin 39% developed de novo symptoms. After withdrawl of cyclosporin symptoms improved in 89%, and withdrawal was associated with an increase in glomerular filtration rate from 67 ± 7 ml/min/l 73 m 2 (mean ± sem) to 79 ± 7 (p < 0.05) and a reduction in plasma creatinine, from 167 ± 17 μmol/l to 148 ± 11 (p < 0.05) and serum bilirubin from 13 ± 1 μmol/l to 10 ± 0.5 (p < 0.05) and alkaline phosphatase from 13.5 ± 1 KAu/dl to 10.6 ± 0.6 (p < 0.05). This suggests that cyclosporin not only has an effect on increasing vascular resistance in the major blood vessels but also affects the microcirculation. Nifedipine, which has been shown to reduce some of the side effects of cyclosporin, reduced the prevalence of Raynaud's following transplantation.


Experiments concerning the properties of soap films have recently been carried out and these systems have been proposed as experimental versions of theoretical two‐dimensional liquids. A silk filament introduced into a flowing soap film, was seen to demonstrate various stable modes, and these were, namely, a mode in which the filament oscillates and one in which the filament is stationary and aligns with the flow of the liquid. The system could be forced from the oscillatory mode into the non‐ oscillatory mode by varying the length of the filament. In this article we use numerical and computational techniques in order to simulate the strongly coupled behaviour of the filament and the fluid. Preliminary results are presented for the specific case in which the filament is seen to oscillate continuously for the duration of our simulation. We also find that the filament oscillations are strongly suppressed when we reduce the effective length of the filament. We believe that these results are reminiscent of the different oscillatory and non‐oscillatory modes observed in experiment. The numerical solutions show that, in contrast to experiment, vortices are created at the leading edge of the filament and are preferentially grown in the curvature of the filament and are eventually released from the trailing edge of the filament. In a similar manner to oscillating hydrofoils, it seems that the oscillating filaments are in a minimal energy state, extracting sufficient energy from the fluid to oscillate. In comparing numerical and experimental results it is possible that the soap film does have an effect on the fluid flow especially in the boundary layer where surface tension forces are large. Copyright © 2004 John Wiley & Sons, Ltd.


force [could] control a large and heterogeneous society over wide territories' (p. 276). It would seem that in spite of its limitations and imperfections, Shāh Rukh's regime provided the stability and patronage that was indispensable: there was certainly no serious alternative in the wings at this time, although with the breakdown of dynastic unity, Timurid rule could be dispensed with. In any event, at times of crisis, let alone of dynastic decline, local solidarity, perhaps combined with increasingly stronger Sufi presence, provided some of the means to deal with political insecurity. I would like to conclude with a thought occasioned by the reading of the book, together with my own understanding of the earlier Mongol period. With all due respect to a well established bureaucratic tradition in Iran and the surrounding countries, represented mainly by families with long-term activity in these fields, one cannot but note the rather ad hoc nature of the administration, compounded by not a little confusion brought about by the ongoing interference of the rulers of Steppe origin. This can be compared to the somewhat more regulated and institutionalised bureaucracies further to the west, be it under the Mamluks or the Ottomans. It might, therefore, not be a complete coincidence that it was these two latter regimes that lasted significantly longer than either the Ilkhanid or Timurid dynasties. Political stability was thus not only a result of the unity and continuity of the dynasty and the ruling military-political elite but also of the regularity and institutionalisation of the bureaucracy that served them. This, of course, requires further research, but works such as the book by Prof. Manz permit us to indulge in comparative thinking on this and other matters in a serious way.


The police create the image of the public security organs,even the whole governments,therefore,it admits of no delay to strengthen on police image building.It requires a proper handling of the relationships between police culture building,police ethics,strengthening on police administration,improving police quality,so as to promote police image among the people.


Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity. In a previous work, we characterized a clonal cell line lacking one TcCRT allele (TcCRT+/−) and another overexpressing it (TcCRT+), both derived from the attenuated TCC T. cruzi strain. The TcCRT+/− mutant was highly susceptible to killing by the complement machinery and presented a remarkable reduced propagation and differentiation rate both in vitro and in vivo. In this report, we have extended these studies to assess, in a mouse model of disease, the virulence, immunogenicity and safety of the mutant as an experimental vaccine. Balb/c mice were inoculated with TcCRT+/− parasites and followed-up during a 6-month period. Mutant parasites were not detected by sensitive techniques, even after mice immune suppression. Total anti-T. cruzi IgG levels were undetectable in TcCRT+/− inoculated mice and the genetic alteration was stable after long-term infection and it did not revert back to wild type form. Most importantly, immunization with TcCRT+/− parasites induces a highly protective response after challenge with a virulent T. cruzi strain, as evidenced by lower parasite density, mortality, spleen index and tissue inflammatory response. TcCRT+/− clones are restricted in two important properties conferred by TcCRT and indirectly by C1q: their ability to evade the host immune response and their virulence. Therefore, deletion of one copy of the TcCRT gene in the attenuated TCC strain generated a safe and irreversibly gene-deleted live attenuated parasite with high immunoprotective properties. Our results also contribute to endorse the important role of TcCRT as a T. cruzi virulence factor.


Although numerous scholars have examined the issue of news coverage of the U.S. Supreme Court, researchers have virtually ignored the parallel and equally significant issue of media coverage of state supreme courts. A few earlier studies examined newspaper coverage of specific state supreme courts, but no studies have examined broadcast and newspaper coverage of all of the nation's state supreme courts. This study therefore evaluates newspaper and television coverage of state supreme courts by surveying the chief justices of those courts. Justices were surveyed about their demographics, public information activities of courts, and perceptions of the overall news coverage and newspaper and broadcast coverage of their courts. Review of literature Relevant to this survey are the numerous books and articles that have scrutinized press coverage of the U.S. Supreme Court, the limited number of commentaries and studies that have evaluated press coverage of state appellate courts, and one study that examined newspaper coverage of the U.S. Court of Appeals. The communication of U.S. Supreme Court decisions to the public received serious attention from scholars in the late 1960s in books by David Grey, Stephen Wasby and Richard Johnson.(1) Those works underscored the uniqueness of the Supreme Court as a news source. The court largely operates in secret and shuns media attention. Fred Graham, who covered the court for CBS and the New York Times, observed: "In a world in which everybody else wanted to be on television, only the justices and the Mafia avoided it."(2) Most of the court's operations are invisible. It accepts for review only three percent of the cases appealed to it; and it provides no explanation for either accepting or rejecting a case. Between the time that a case is accepted by the court and the release of a court decision, only one public event occurs. Attorneys for both sides appear in a public session of the court for one hour of oral arguments. The Supreme Court is most newsworthy when it files a written decision that decides a case, which in the 1990's occurs about 100 times a year. The filing of Supreme Court decisions is unlike other news events in Washington, D.C. There is no advanced warning of when a specific case will be decided. And the written decisions must stand on their own as sources about the court's actions; neither judges nor court personnel will interpret the decisions. Also unlike other Washington, D.C., institutions, there are very few news leaks at the Supreme Court. Any conjecture about court decisions must come from legal authorities outside of the court. Most studies of news coverage of the U.S. Supreme Court have examined the quality and quantity of the content of newspaper stories, editorials and opinion columns. However, one study by Ethan Katsh examined network television coverage of the court.(3) The study of the last five court terms of the 1970's found that networks covered 20 percent of court decisions, with half of those covered by the networks' legal affairs specialists who had law degrees. Another study examined Supreme Court coverage by the three U.S. newsmagazines. Dorothy Bowles and Rebekah Bromley(4) measured coverage of eight court terms in the 1980's and found that 10 percent of decisions were covered, down from 15 percent in a 1970's study. They also found that the decision stories were quite thorough. For example, 89 percent of the stories discussed the reasoning of the majority court opinion. The issue of the quality and quantity of Supreme Court coverage continues to attract attention from scholars, media commentators and even members of the court. A 1993 study by Elizabeth Atwood-Gailey evaluated editorial coverage of the controversial Rust v. Sullivan decision in which the court upheld a Reagan Administration policy that prevented medical clinics that received federal funds from informing patients about the option of abortion. …


Introduction: The estimation of age at the time of death is often an important step in the identification of human remains. If the age can be accurately estimated, it will significantly narrow the field of possible identities that will have to be compared to the remains in order to establish a positive identification. Recent research shows that Secondary dentin deposition, root translucency, and cementum apposition in a combination may be used more reliably than the combination of six factors (attrition, periodontitis, root resorption, secondary dentin deposition, root translucency, and cementum apposition). Materials and Methods: A study sample consisted of 95 patients undergone extraction, extracted teeth were collected and utilized for ground sections, sections were grinded until the thickness of 1-mm, on this thickness root translucency was noted, teeth were further undergone grinding up to 0.25 mm thickness afterward they were viewed under microscope for secondary dentin deposition and cementum apposition. Results: By using the combination of these three factors for age estimation we got a mean error of ±4.51. Discussion: Present study is confirmed that secondary dentin deposition, root translucency, and cementum apposition are more reliable factors or strictly age-related factors and provides many accu rate results.


Objective To investigate the incidence and risk factors of contrast-induced nephropathy (CIN) in super-elderly patients undergoing percutaneous coronary intervention(PCl).Methods 412 patients over 60 year old undergoing PCI were divided into super-elderly group(over 75 year old, n=183) and elderly group(60~75 year old, n=229), underlying diseases,perioperative serum creatinine level, CIN incidence and effect of rehydration therapy were reviewed in two groups and the risk factors of CIN were evaluated in super-elderly group. Results Compared with elderly patients, super-elderly patients had more underlying diseases and higher CIN incidence (25.2% vs 10.5%; P0.05 ),the level of Scr in CIN patients of two groups at the first day and the third day post PCI was higher than that before procedure(P0.01), but decreased to normal at the seventh day.Identified by logistic regression, the risk factors of CIN in super-elderly patients included hypertension, heart failure, renal dysfunction, diabetes mellitus, renal dysfunction combining with diabetes mellitus and contrast volume. Conclusion The incidence of CIN in super-elderly patients was higher than that in elderly patients, which was related to higher age and more risk factors.Risk factors evaluation and rehydration therapy should be given prior to procedure.


Introduction: Electronic cigarettes (e-cigarettes) produce an aerosol by heating a liquid. Users can buy ready-made electronic liquids (e-liquids) or make some on their own by mixing together appropriate proportions of ingredients. The aim of this study was to determine users' motivations for manufacturing e-liquids on their own and their awareness of the associated dangers among participants in online forums concerned with e-liquids. Material and methods: We conducted a quantitative and qualitative analysis of online forums and portals related to e-cigarettes. The data was acquired with SentiOne monitoring of respecitive sites. For the detailed analysis, 200 comments were used, all of them written in Polish, between 1 January 2020 and 30 June 2020. The comments were classified into three categories: advice, safety, and motivation for producing Do-It-Yourself (DIY) e-liquids. Results: Most of comment (56%) contained request for advice and respective recommendation on production of e-liquids. We identified four main motivations for producing e-liquids on one's own: obtaining a particular flavour, aroma, cutting down on e-liquid costs and desire to quit traditional cigarettes. Safety-related issues were discussed in 34% of the postings. Most of them showed an awareness of certain dangers arising from the use of e-cigarettes and DIY production of e-liquids. Conclusions: While choosing the ingredients and/or their proportions for the individual e-cigarettes' production, users were relating to another users' experience or e-liquid calculators, which correctness is not subject to control. Ingredients required for producing e-liquids are purchased from physical shops and the online platform allegro.pl. The main motivations for producing e-liquids at home comprised cost and flavour. The intended introduction of additional taxation by Polish government may induce e-cigarette users to consider switching to cheaper alternative – DIY e-liquid production.


Children were not selected over the whole range of either ability, as measured by any given test. The talented children were chosen on their performing ability by their specialist music teachers in and out of school, and by two art experts. The opinions of such people are customarily used as validation in assessing tests of ability. The musical children all played orchestral instruments. In the research area (Salford, Lancashire), access to an instrument and tuition is relatively easy to obtain. Salford provides a music centre where two children's orchestras practice, and, in addition, a group of children talented in the graphic arts are selected from all the City schools, and are given extra lessons in a special class.


The paper mainly discuss the multi-wavelets theory proposed by Charles A Micchelli and Yuesheng Xu.On this basis,we talk about the derivation of fractal multi-wavelets filter with the interval characteristic of self-affine and the usage of it.According to the ordinary derivation method of biorthogonal multi-wavelets filter.


Lyapunov function method is especially effective for controllable Hamiltonian systems. For such systems, control is chosen so that save the Hamiltonian form of the equations and the Lyapunov function is based on the Hamiltonian function. This approach allows us to achieve the Lyapunov stability of stationary solution.


The invention relates to a closure cap (2), which is prepared for mounting, in particular for plugging, to an, in particular tubular nozzle-like, connection port (30) of a cartridge-shaped container and in a mounted state a sealing of the connection port (30) is used, with a particular circular shaped, upper surface portion (6), a subsequent, in particular vertical and cylindrical, the top surface portion (6) adjoining the lateral surface portion (8), and located at the lateral surface portion (8), in particular annular flange portion (10), wherein the flange portion (10) a sealing portion (14), over which the cap (2) on the cartridge-type container is fixable and sealable, and a predetermined breaking - / - ruptured portion (18) on which the closure flap (2) of the closure cap (2) during the removal predefined by the cartridge-type container to crack and / or break aufwei st and / or formed.


This paper deals with the application of nano technology in the pyro industries located in Sivakasi. This paper also gives information about the geography, history, location of industries, pyro powder manufacturing companies, application of SEM, ball mill present in Sivakasi. Sivakasi is one of the most mega industrial centres present in India. Sivakasi is also called as Kutti Japan due to the enormous amount of industries present in the heart of the city. It is one of the important holy places present in the country. It is having hot climate throughout the day. Nowadays, due to El - Nino the climate conditions were changed. There is an abundant rainfall in the summer season also. This paper is useful for the students to study about the pyro industries present in sivakasi and the applications of nano technology in the pyro industries present in the city. Hereafter, the pyro industries using the nano technology for the improvement of the quality and performance of the fireworks present in Sivakasi shall also be called "Nano pyro industries" and the city can also be called as "Nano Pyro Industrial City". Pyro industries are present in the city due to the low annual rainfall and the dry climate present in the city throughout the year. The land in Sivakasi is also called as "Sulphur land" due to the heavy temperature in the city. Nowadays, the trend is changed due to the climatic changes caused by El - Nino. In the year 2015, the summer season in sivakasi was converted into rainy season by the climatic changes caused by the unstable changes in the winds from the Bay of Bengal.


ABSTRACT— Lisuride at a mean daily dose of 3.2 mg was given to 15 untreated idiopathic Parkinson's disease patients. There were 10 dropouts, due mainly to inefficacy in the first months of therapy. The parkinsonian pattern in the patients who remained in the study for the full 4 years showed distinct improvement, which was maintained for less than 2 years. The patients did not develop "on‐off" phenomena or abnormal involuntary movements during follow‐up.


Abstract
Patient data is central to a Clinical Information System (CIS). The organization of the data in a patient database is essential to the functioning of the system. If the CIS contains a medical decision support component, further requirements are imposed on the database. It must be capable of accurately representing a broad range of clinical information in coded form, and be organized for efficient retrievals by patient, time, and type of clinical term.

This paper presents a generalized schema for a clinical patient database within the relational database model. The general design makes it possible to represent diverse clinical data in a standard structure and to organize the data so that it is densely clustered by patient and time.


Hybrid model combines presential instruction with online learning. It has been used an alternative to minimize contact with social people caused by COVID-19 pandemic in Amazon state. The aim of this study was to analyze the perception of high school technical students related to the challenges and advances in Technological Education during remote teaching in Amazon countryside. Methodology was qualitative and exploratory approach, with the application of a structured questionnaire with objective and dissertation questions, aimed at students at the IFAM Coari Campus. As a result, it was found that students know how to use technological tools, but they do not always have access to individually equipment computer and cell phone and with access to the internet. This highlights the socioeconomic difference and the need for strategies that can subsidize egalitarian education regardless of the economic issue of the participants. At the same time, it was found that teachers are seeking to promote quality education, capable of minimizing the obstacles resulting from student's socioeconomic inequalities, another common variable in the speeches of both teachers and students is the operationalization of classes in a safe way to comply with the school calendar for the 2020 school year.


This paper compares the calculation of heating energy
need according to the Hungarian official methodology
used for the certification of buildings and the seasonal
method in the EN ISO 13790 standard. Both methods
have a similar structure, but the Hungarian method
contains several simplifications. A major simplification is
that dynamic parameters in the utilisation of heat gains
are not calculated, but the utilisation factors are fixed
values for two categories of buildings (lightweight and
heavyweight). This paper analyses the error as a result of
this simplification on an example residential and office
building. To increase the number of cases, a Monte Carlo
analysis is performed with varying parameters of the
geometry of the building, the orientation, thermal transmittance,
window-to-wall ratio, shading and internal heat
capacity.
According to the results, the Hungarian methods
consequently overestimates the heating energy need by
3–4 kWh/m2a on average, which is acceptable for
conventional buildings. However, for very low energy
buildings with high internal heat gains it is advisable to
calculate the utilisation factors according to the 13790
standard, as in this range the Hungarian method may
underestimate the energy need.


BACKGROUND
Marginal zone lymphomas (MZL) are indolent B-cell lymphomas with variable symptoms related to lymphoma location. Patients with such lymphoma often have an excellent prognosis. Concerning treatment, no large prospective trials have been published, making therapeutic decisions difficult.

CASE REPORT
The Authors present the case of a female patient with an MZL which was slowly progressive throughout 9 years after diagnosis. Only clearly progressive lymphoma manifestations were treated with moderate-dose radiotherapy (total doses between 30 and 40 Gy). All irradiated lesions showed a complete regression and relapses only occurred at non-irradiated sites. The performance status remains very good.

CONCLUSION
Moderate-dose radiotherapy is a safe and effective treatment to achieve local tumor control in patients with MZL.


The six new dihydro-β-agarofuranoid sesquiterpenes 1–6 and three known compounds were isolated from the whole plant of Celastrus paniculatus. The structures including relative configurations were elucidated by means of spectroscopic analyses. Compounds 1–6 were evaluated for cytotoxicity against a panel of three human-tumor cell lines.


In this issue of CA, Kathryn O'Brien of the American Cancer Society (ACS) and colleagues review cancer incidence, mortality, and selected cancer-related behaviors of Hispanic Americans and compare them with those of non-Hispanic Americans. The report is a classic example of a good news, bad news situation. The good news is the lower rates of incidence and mortality from the four major cancer killers; the bad news is the higher incidence and mortality from several cancers in which infectious agents play a substantial etiologic role. The good news is the lower smoking rates among Hispanic adults and youth; the bad news is that much of this difference may be among immigrants, and that secondand third-generation Hispanic Americans remain vulnerable to tobacco marketing. The good news is that use of cancer screening tests and examinations has been increasing among Hispanics and that mammography use among Hispanic women exceeds the national average; the bad news is that prevalence of screening for colorectal, cervical, and prostate cancers among Hispanics remains considerably below average. The final bad news is higher rates of overweight and obese individuals and higher rates of physical inactivity. What is clear about this report is that patterns of cancer incidence, mortality, and behavioral risk factors for Hispanics differ sharply from the patterns of other racial and ethnic groups in the United States. Finally, it should be stated, the report raises many more questions than it answers. We have to be careful when talking about Hispanics. Hispanics are a very diverse group of people with varying beliefs and identities. Hispanics are the fastest-growing and largest ethnic and minority group in the United States. Although Hispanics are united by ethnicity, language, music, culture, and traditions, they also retain some distinguishing customs from their individual homelands. Hispanics originate from 23 different countries and belong to all known human races. This reality needs to be taken into account when analyzing health-related data. It is possible that this enormous diversity may explain the different patterns of cancer incidence, mortality, and cancer-related behaviors. The main problem is that Hispanics living in the United States are disproportionately affected by some disparities. Despite having the highest rate of labor force participation of all US population groups, Hispanics are the poorest minority group. In addition, they report the highest uninsured rate among all racial or ethnic groups. According to the US Census, there were 35.3 million Hispanics living in the United States in the year 2000. During the same year, 35% of Hispanics lacked health insurance. This represents more than 12 million people for whom going to see a doctor may constitute a financial hardship. In addition, the uninsured are less likely to get preventive care such as physical examinations and cancer screening. Other barriers to adequate access to quality health care include linguistic isolation, insufficient health information, scarcity of ethnically sensitive and culturally competent health facilities, and their lack of understanding of the US medical system. The Hispanic community does not have access to the same quality of care as mainstream Americans. One fifth of this community lives in poverty (a figure twice the national average). Many do not understand the importance of early screening tests because they were not provided with linguistically and ethnically sensitive information. First-generation Hispanic migrants have higher rates of cancers etiologically related to infectious agents, again reflecting in part limited educational opportunities and public health/health care infrastructure in some of their home countries. Many Hispanic Americans, and first generation immigrants in particular, have a low awareness of services available to them; they fear the unknown, and the medical system can be seen as intimidating and impenetrable. The Dr. Huerta is Director Cancer Preventorium, Washington Cancer Institute at Washington Hospital Center, Washington, DC.


Ovarian cancer (OC) is the deadliest gynecologic malignancy with a dismal prognosis worldwide. A key reason for this is that most patients already have extensive metastasis at the time of diagnosis. Therefore, it is metastatic disease that is being treated in the clinic. However, metastasis remains one of the least understood aspects of cancer biology and a better understanding of the mechanisms involved will be helpful in devising more effective therapies. Transcoelomic metastasis is prevalent in ovarian cancer, which involves exfoliation of cancer cells in the primary tumor, floatation and spreading in the peritoneal fluid, followed by attachment, and colonization of the peritoneal organs. The most common site being the omentum. Recent research has indicated that a small percentage of OC cells, called metastasis-initiating cells (MICs) are able to survive at the metastatic site and establish metastases. However, the characteristics of MICs, their productive interactions with the metastatic microenvironment, and how they colonize metastatic sites, remain poorly understood. We attempted to address this issue with a focus on high grade serous OC (HGSOC), the most prevalent and lethal subtype of OC. We used HGSOC cells isolated from patient ascites and seeded them on an organotypic 3D culture model of the surface layers of the omentum to mimic early stage of metastatic colonization. The same cells were injected intraperitoneally in NSG mice to generate patient derived xenografts, representing advanced metastasis. Single cell transcriptomics was performed in both these models to identify the heterogeneity of the patient derived OC cells and the changes in their subpopulation profiles during early and advanced metastasis. Inference of activity scores of gene sets (AUCell), analysis of regulons (SCENIC) and identification of markers (Seurat and CytoTRACE) of the single-cell transcriptomic data helped characterize the MICs. We identified one distinctive population of OC cells with MIC-like phenotype. Utilizing trajectory analysis (Monocle3) we have determined the potentially targetable differentiation trajectories between the MICs and other cancer cells populating the established metastases. Intra-tumoral interactions were also investigated using CellCall to identify targetable ligand-receptor pairs. Elimination of MICs, interference of intra-tumoral communications inducing stemness of MICs, or interruption of their differentiation trajectory paths that help establish the metastases, may be a novel therapeutic opportunity leading to improved outcomes for the OC patients who are diagnosed with metastasis.
 Citation Format: Ji Wang, Subramanyam Dasari, Chi Zhang, Anirban Kumar Mitra. Regulation of initiation and establishment of ovarian cancer metastasis by metastasis initiating cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2434.


In view of including the data of the study "Clinical evidence of efficacy of red yeast rice and berberine in a large controlled study versus diet" by Trimarco B, Benvenuti C, et al. Mediterr J Nutr Metab (2011) 4:13–19, in an international based meta-analysis, it was judged appropriate, for reason of total transparency, to add more information concerning the methods that were applied. These amendments to the paper, are based on the operative procedure contained in the official protocol "Controlled clinical study on Armolipid Plus, food supplement active on cholesterol and triglycerides in CV risk and metabolic syndrome control". The study concerns a food supplement, a class of products that usually is not (or scarcely) documented as not required for marketing authorisation. In Methods section the basic criteria of the study design were reported, representing the condition of the Italian real world, to obtain reliable clinical data on efficacy and safety. The protocol was delivered to the centres accompanied by a case report form in which both activity and safety parameters could be reported. A specific section was dedicated to adverse events description. Design of the study: due to the huge amount of the involved centres (248), a double blind placebo type was not judged practically feasible from the operative point of view: providing double blind supplies for up to 16 weeks in so many centres requires an extraordinary logistic effort, whose benefits could be considered marginal versus the planned large amount of data to collect. In fact, the main end point was represented by objective measures (blood lipids) that were determined by laboratories working under the normal routine and not aware of the treatment followed by the subject, allowing to consider the design as "functional double blind". Each centre was provided a balanced randomisation list (random ratio 2:1 was accepted), and the centres that did not complied with it, were discarded to avoid bias in the comparison. The protocol fixed as 8 weeks the minimum duration of treatment. Concerning the duration of the treatment, it should be specified that: 8 weeks was the minimal duration of treatment on which the sample size was calculated, and the centres where left free to extend the treatment up to 16 weeks according to the attained result and the availability of the subject to continue it. The planned 8 weeks' visit was respected by most of the subjects: 707 out 933 (75.8%) in diet group and 786 out 818 (96.1%) on AP for total cholesterol. Part of the centres evaluated the parameters even at 4, 12 and 16 weeks. The type of real world study and the inclusion of centres homogeneously spread along Italy, explains the differences in the final number of exams performed at same visit, as each doctor applied his habit to keep under control this type of subject.


ABSTRACT Poly-3-hydroxybutyrate (PHB) has been extensively utilized as a biodegradable plastic. The value of substrate inhibition constant (K I) was also established in shake flask cultures by varying the initial glucose concentration (20–160 g/L) in growth media. Excess carbon source adversely affected the growth of Bacillus subtilis cultures. The production kinetics of PHB was studied using batch fermentation strategy for B. subtilis culture. Batch cultivation was also performed in a 5-L stirred tank bioreactor to obtain a Biomass and PHB yield of 5.25 and 1.6 g/L, respectively. The kinetic data of biomass, PHB production, and substrate consumption was used to estimate the optimized values of the growth and product formation kinetic parameters. Optimal values of kinetic parameters (µ m value of 0.325, K S value of 10.53 g/L for glucose, Y value of 0.183 g/g of glucose, K I value of 105 g/L, m value of 0.12 g/(g h), k 1 of 0.36 g/g, and k 2 value was 0.12 g/(g h)) and the initial values of biomass, substrate and PHB concentration (X = 0.14 g/L, S = 9.99 g/L, and P = 0.13 g/L) were utilized to obtain a modified mathematical model for PHB production. Statistical validity of the mathematical model simulations were measured using F-test. The F-test showed that the statistical validity of the model was more than 95% when compared with experimentally obtained values. This model also predicted that the production of PHB using B. subtilis cultures is mainly growth associated.


Business administration plays a pivotal role in maintaining economic growth and ensuring the normal operation of the market. However, under the new normal, China's economy has been transformed from the crude development mode in the past to a refined development mode, which puts higher demands on the functions of business administration. The article starts from the overview of the new economic normal, briefly introduces the problems faced by business administration under the new normal, and discusses its function, so as to promote the intelligent level of business administration for business administration in China.


Arguing for an open reading of the works and describing four Ontario artists' work, Fry elaborates on their use of materials, processes, and meanings in relation to painting and sculpture. Statement by Koh and McKay. Biographical notes.


Basketball game is one of college students' favorite sports items and the main course in college PE teaching. However, during the college PE teaching reform process, the weaknesses existing in the traditional teaching ideas and teaching ways are continually appearing. Through literature review, expert interview and logic analysis, according to the present development of basketball discipline and college students' characteristics, the article makes a study on different basketball teaching methods and tries to form systematic ways, in hope to improve basketball teaching efficiency. It also helps to make college basketball teaching fit the quality education and the lifelong education better, improve students' overall quality and respect their main role. In this way, basketball game can really become one course that is very welcomed by students and is good for their physical and mental development and contributes to the talent training in the new century.


Shadow "banks" are unidentified entities operating in the financial sphere, in different countries. Therefore their lending and borrowing activities must be based on some rationally determined interest rate. We make the hypothesis that it is determined by a Reinforced Learning process and try to model this behaviour alongside a classic CCLM/DSGE model. This is a follow-up from the presentation made at EcoMod July 2012 Seville "A Markov random model of Interbank Dynamics with Filtering and Learning". We go farther in the implementation of the model. Starting from a DSGE equilibrium, forward simulations are made using Sequential Monte Carlo and interacting particle systems technique. Loopbacks are made with RL equations implemented in a dozen of heterogenous agents as "shadow bankers", each with own set of utility preferences and learning capacities. Tentatively, it appears that in a interbank liquidity shortage environment, the "shadow entities" will split up into 2 categories according to risk aversion and learning speed and their own size. I will upload a first version of the paper in February.


Abstract Acclimatization of sugarcane plantlets (Saccharum spp. hybrid) var. C91-301, micropropagated in temporary immersion bioreactors, was studied. When in vitro plantlets were transferred to acclimatization conditions, photosynthesis increased only slightly during the first 7 d. After this period, the increase was constant with only a small decline after transfer to uncontrolled external conditions. Production of fresh and dry weights, number of leaves and roots, leaf area, stomatal density and chlorophyll contents were evaluated during the acclimatization period. From day 14 on, sugarcane plantlets exhibited low but positive photosynthesis due to the new formation of leaves and roots. The increase in light intensity and the gradual reduction of relative humidity during acclimatization did not constitute inhibitory factors, as can be interpreted from the increased photosynthetic activity until 21 d. Stomatal density and leaf area after 21 d were also increased, while the chlorophyll content declined.


Presidential election in Indonesia considered as a big event which held in every 5 years. Presidential Election July 9 2014 is one of the important event in Indonesia and the capital market shows that there are some reactions of the event. This research aims to see how the reaction of capital market by looking at the differences of each three variabel in this research, they are bid ask spread, abnormal return, and trading volume activity before and after presidential election, July 9 2014. The research object is 45 companies which listed in LQ-45 Index period during February – July 2014. The observation period is 24 days which is 12 days before and after presidential election event at July 9 2014. This hypothesis test used paired sample t-test analysis. The result of this research shows that there is no significant differences beetween bid ask spread before and after presidential election, there is no significant differences beetween abnormal return before and after presidential election, and there is a significant differences beetween trading volume activity before and after presidential election.


Certain problems in acoustic thermometry of ocean climate (ATOC) require evaluating the response of modal group speeds to perturbations in the ocean sound‐speed profile. Two different approaches have been taken recently by researchers, resulting in two perturbation expressions whose equivalence is not immediately evident. The first approach, used by Lynch et al. [J. Acoust. Soc. Am. 89, 648 (1991)], results in an integral equation involving the frequency derivative of the eigenfunctions. The second approach, under current investigation, yields an integral equation involving the response of the eigenfunctions to sound‐speed perturbations. The two expressions are shown to be equivalent by means of their projections onto the set of modal eigenfunctions. These results are discussed in relation to group travel‐time tomography.


The purpose of this community service activity is to improve the managerial capabilities of non-formal educational institutions during the covid-19 pandemic, especially in the monitoring and evaluation functions. This activity was attended by administrators and representatives of the Communication Forum of the Community Learning Center (FK-PKBM) in Bengkulu Province. The method used in this devotional activity is a workshop using zoom cloud meeting. Approach with material resource methods and resource person. Data collection techniques with questionnaires and competency assessment instumen seen from the readiness of institutions in simulated performances prepare monitoring documents and evaluation of institutions. The results of the assessment of the implementation fall into the category of good, when viewed from the preparation of the workshop, the implementation of the workshop, the competence of the presenter, the material delivered and the use of media in the good category. The assessment of the workshop participants is averaged in good category. However, if you look at the comparison between theoretical materials and practice, theoretical materials are easier to master by workshop participants. This is inseparable from the lack of focus of participants in following every stage of the material related to practice because of the busyness other than zoom meetings conducted while doing other work and network problems that also often interfere with participants to join in the zoom cloud meeting. Keywords: Monitoring, Evaluation,Community Learning Center


The invention provides a toon-fragrance type nutrient wine that has special toon-fragrance and functions of appetizing, ventilating, clearing heat and detoxicating, and its making method. Its technical key point lies in its raw materials in weight percent: kaoliang 40-60, corn 10-20, wheat 10-20, pea 4-6, toon bud 2-5, selenium-rich yeast 0.1-0.3, flavoring wine 0.6-1.2, and purified water 10-30. On the basis of traditional wine-making process, taking the distilled unstrained spirits out of utensils, getting a load of water, spread-airing and cooling and then scattering the yeast, putting a part of them together with the toon buds and selenium-rich yeast in the cellar for fermenting; steaming the unstrained spirits out of the cellar in the utensils, then uniformly spreading them, throwing a part of toon buds, and distilling to extract a distiller's yeast containing toon fragrance; using the distiller's yeast as wine base, adding pulp to blend, and obtaining it, which has the effects of appetizing, ventilating, clearing heat and detoxicating.


The secondary structure flexible region of protective antigen RfeA against Streptococcus suis serotype 2(S.suis 2)was analyzed by the Garnier-Robson's method,the Chou-Fasman's method and the Karplus-Schulz's method based on their putative amino sequence.Hydrophilicity plot,surface probability plot and antigenicity index were obtained by the methods of Kyte-Doolittle,Emini and Jameson-Wolf,respectively.B cell epitopes for RfeA were predicted based on these results The predicted B cell epitopes for RfeA were located at the N-terminal No.21~27,53-60,104~117,140~160.Taken together,prediction of the B cell epitopes for protective antigen RfeA against S.suis 2 based on multiple parameters would lay foundation for experimental research of multi-epitope vaccine against S.suis 2.


From purpose and scope: and primary objective was to determine the extent and grade of ore present and the future potential of the district. The second and broader objective was to learn the relationship of ore to stratigraphy and structure,
in order to outline similar areas favorable for prospecting.


In this paper we investigate the existence of solution for the following nonlocal problem with anisotropic Stein-Weiss convolution term $$ -\Delta_{\Phi} u+V(x)\phi(|u|)u=\dfrac{1}{|x|^\alpha}\left(\int_{\mathbb{R}^{N}} \dfrac{K(y)F(u(y))}{|x-y|^{\lambda}|y|^\alpha}dy\right)K(x)f(u(x)),\;\;x\in \mathbb{R}^{N} $$ where $\alpha\geq 0$, $ N \geq 2$, $\lambda>0$ is a positive parameter, $V,K\in {C}(\mathbb R^N,[0,\infty))$ are nonnegative functions that may vanish at infinity, the function $f\in C (\mathbb{R}, \mathbb R)$ is quasicritical and $F(t)=\int_{0}^{t}f(s)ds$. To establish our existence and regularity results, we use the Hardy-type inequalities for Orlicz-Sobolev Space and the Stein-weiss inequality together with a variational technique based on the mountain pass theorem for a functional that is not necessarily in $C^1$. Furthermore, we also prove the existence of a ground state solution by the method of Nehari manifold in the case where the strict monotonicity condition on $f$ is not required. This work incorporates the case where the $N$-function $\tilde{\Phi }$ does not verify the $\Delta_{2}$-condition.


Let A and B be Arens regular then we want to know which condition we need that the projective tensor product A⊗̂B be Arens regular. Conversely, if A⊗̂B is Arens regular, then dose A or B are Arens regular. In final, we conclude that c0⊗̂ ∞ is Arens regular. Mathematics Subject Classification: 46L06; 46L07; 46L10; 47L25


Purpose – The purpose of this research is to present an alternative to the vast majority of studies on chief executive officer (CEO) compensation practices in the USA which have relied on multiple regression analysis and its variants.Design/methodology/approach – The paper points out the shortcomings of traditional parametric approaches (such as regression analysis) to the analysis of CEO compensation practices and suggest non‐parametric alternatives.Findings – Using tests for concurrent validity, the paper demonstrates how non‐parametric assessment may be successfully applied to the analysis of CEO compensation practices.Originality/value – Because of the novelty of this approach, the findings should be of value to those academics and practitioners interested in the evaluation of CEO compensation practices.


Mr.Jiang Yin believes that the "image" discussed in the academia in the past should actually be called "physical image",and that "ideorealm" is a completely self-contained text.Ancient people used the concept of "ideorealm" only to determine and select the "realm",and the term "ideorealm" is neutral,void of any value judgment.This paper believes that "image" is the smallest ideographic unit,while "realm" or "ideorealm" is a larger ideographic unit.Mr.Jiang has ignored the fact that in China people think of "image" as "expression" rather than "representation".This paper explores the characteristics of "image" from the perspective of its "expression".


Voltage sag tolerance levels were measured for samples of three equipment categories sensitive to sags: contactors, PCs and gas discharge lamps. An up-to-date voltage waveform generator was used to produce and repeat the events as necessary. Remaining voltage and sag duration were the test variables. For contactors also the effect of point-on-wave of sag initiation was studied. The results were rather well convergent with earlier studies by other institutes. This justifies more generalized conclusions on performance of these device categories as well as more statistical approach to the issue. This kind of typical equipment sensitivity data is needed as a library for the future sag assessment methods.


Personality models for interactive storytelling must meet a different set of requirements than scientific personality models. This paper presents the considerations that apply to the creation of such personality models.


The paper reports on the experience regarding usability evaluation of broad-reach web portals. The designed methodology advocates a number of usability test methods along with specialists' inspection and provides a comprehensive quantitative and qualitative assessment feedback. Our experience accords with the claim that we should not rely on isolated evaluations, but instead on combine assessment methods. In this paper we present and discuss mainly the results obtained through user-based usability evaluation. The results indicate that chosen research instruments, measures and methods for usability testing were consistent. Conversely, the results of the designed guideline inspection did not conform to the ones obtained through the end user testing. Although proved promising, some of the guideline-based evaluation aspects need improvement.


Cuthbert Ttinstall, last Catholic Bishop of Durham, exercised an episcopate of close on thirty years, at a period most momentous in the history of the Church in England. Appointed in 1529 and reckoning his pontifical years from 25 March, 1530, he died, in house confinement at Lambeth Palace, 15 November, 1559, three months after his final deprivation.


An efficient signaling equilibrium with dividends and investment, or equivalently, dividends and either sales or repurchases of stock, is constructed and its properties are identified. Because corporate insiders can exploit two signals, the efficient mix minimizes dissipative costs. In equilibrium, many firms both distribute dividends and deviate from first-best investment. Also, the impact of dividends on stock prices is positive. By contrast, the announcement effect of new stock is negative for firms with private information primarily about assets in place and positive for firms with inside information mainly about opportunities to invest. Copyright 1987 by American Finance Association.


Abstract Predictions of the eddy viscosity K are presented for neutrally stable flow in the surface layer after a change in surface roughness. These predictions indicate that the standard techniques for estimating eddy diffusivities or exchange coefficients may lead to substantial errors for flow over heterogeneous terrain.


The recommendation to avoid high dietary "salt" intake for the prevention and treatment of hypertension is often expressed in terms of dietary sodium. However, a consistent body of evidence suggests that the chloride component of salt is an important contributor to NaCl-induced elevations of blood pressure.1 In several rat models of salt-sensitive hypertension (Dahl salt-sensitive [S] rat, DOCA-salt hypertension, stroke-prone SHR [SHRSP], angiotensin II-induced salt-sensitive hypertension), selective dietary sodium loading, in the absence of chloride, fails to produce hypertension. In various feeding protocols, anions provided with sodium included various combinations of bicarbonate, phosphate, aspartate, glutamate, and glycinate. Overall, the failure of selective dietary sodium loading to produce hypertension in these studies was not related to group differences of body weight, net sodium balance, blood pH, or serum concentrations of sodium, potassium, or chloride.

Similarly, a limited number of clinical observations also indicate that blood pressure is not increased in humans by high dietary sodium intakes in the absence of chloride. In 1929, Berghoff et al reported that blood pressure increased in 7 hypertensive individuals on a high NaCl intake, but not on a high sodium bicarbonate intake.2 This observation was subsequently confirmed.3 Similarly, other investigators have also observed that in contrast to the increase of blood pressure induced by a high NaCl intake in hypertensive patients, blood pressure is not increased by a high sodium intake provided as sodium phosphate or sodium citrate.1 Further suggesting a modulating effect of dietary chloride on blood pressure, in hypertensive and normotensive subjects, substitution of dietary NaCl with equimolar sodium bicarbonate leads to a reduction of blood pressure.4,5 Additionally, in hypertensive humans, the reduction of blood pressure by dietary potassium is attenuated by potassium chloride compared with that of potassium citrate.6

Because the blood pressure increment in response …


JA and IRK acknowledge support from STScI grant GO-11688 and
GO-12669. PB was supported in part by the NSERC Canada and
by the Fund FRQ-NT (Quebec).


In practical applications,people need database technology for saving data in order to query or modify the data in the future.Introduces the framework of the GTK application based on Linux.Then briefly describes the background on the glade and how to program with the combination of the GTK library and glade library.At last,canvases the way of developing database applications based on C language with MySQL and GtkTreeView,one of widget of the GTK+.The practice shows the effectiveness of this way.


Chromium nitride-based coatings, 3 [mu]m thick, were deposited by reactive sputter deposition on polished AISI 304 stainless steel substrates. By varying the reactive gas content it was possible to produce coatings of various compositions, namely CrN, CrN[sub 0.55], and Cr(N, O) coatings. The corrosion resistance of these coatings was evaluated by measuring the anodic polarization curves in 0.5M H[sub 2]SO[sub 4]. Compared to the uncoated substrate a decrease in corrosion current density for approximately two orders of magnitude is obtained on coated samples. Postdeposition heat-treatment at 450 C in an oxygen flow for 24 h had a beneficial effect on the corrosion characteristics of the nitride coatings. Auger electron spectroscopy depth profiles revealed that postdeposition treatment induced the partial transformation of nitride to Cr-oxide and Cr oxynitride layers on the surface. The thickness of the Cr-oxide layer formed is dependent on the composition of the underlying nitride coating, increasing with decreasing nitrogen content.


One of the longest unwritten chapters of the Iiistorv of the United States is that treating of the relations of the Negroes and Indians. The Indians were already here whien the white men came and the Negroes brouglht in soon after to serve as a subject race found amiiong the Indians one of thieir means of escape. That a larger number of the Negroes did not take refuge among the Indians was due to the ignorance of the blacks as to the geographic situation. Not knowing anything about the country and unacquainted with the language of the white man or that of the Indians, most Negroes dared not venture very far from the plantations on which they lived. Statistics slhow, however, that in spite of this impediment to the escape of Negroes to Indian communities, a considerable number of blacks availed themselves of this opportunity. From the most northern colonies as far south as Florida there was much contact resulting in the interbreeding of Indians and Negroes. In no case was this better exemplified than in Massachusetts. Because of tlle cosmopolitan influences in that State where the fur trade, fisheries, and commerce brought the people into contact with a large number of foreigners, the Indian settlements by an infusion of blood from without served as a sort of melting pot in which the Negroes became an important factor. There was extensive miscegenation of the two races after the middle of the seventeenth century. In the course of ten or twelve generations there was an opportunity for "foreign blood early introduced to permeate the whole mass and when it is considered that the intermixture was constantly kept up from the outside, it is a wonder that Iindians of pure native race remnained."1


The Pakchong-1 hybrid cultivar is a highly productive forage grass cross between elephant grass and pearl millet grass (Pennisetum purpureum x Pennisetum glaucum). The research objective was to determine the growth and production response of Pakchong-1 elephant grass to different fertilizer doses and cutting ages. The study was conducted at the JASTRU (Jonggol Animal Science Teaching and Research Unit) of IPB University. This study used a 3 x 3 factorial completely randomized design (3 doses of nitrogen fertilizer x 3 cutting ages) with 4 replications. The data was analysed using ANOVA and the Duncan Multiple Range Test. The fertilizer doses used were 100, 200, and 300 kg ha-1, and the cutting ages were 50, 60, and 70 days. The research results showed that the cutting age significantly increased plant height (180.53 – 210.90 cm), dry leaf weight (3.90 – 5.63 tons ha-1), dry stem weight (2.32 – 4.38 tons ha-1), and total dry weight (6.22 – 10.02 tons ha-1). However, biomass production was not affected. There was an interaction between the fertilizer dose and cutting age in terms of the number of tillers (1.99 – 5.15 tillers per clump) and the number of leaves (5.55 – 11.18 leaves per plant).  Based on the research, the optimal point for obtaining the best results in terms of plant height growth, number of leaves, number of tillers, production of fresh biomass, dry weight of stems, dry weight of leaves, and total dry weight of Pakchong-1 elephant grass was a cutting edge of 60 days and the addition of 100 kg ha-1 of fertilizer.
Key words:        cutting age, fertilizer dosage, forage production, growth of pakchong


A method for recovering a stress protein from a plant comprising - obtaining a liquid comprising the stress protein from the plant; - precipitating one or more components other than the stress protein liquid; - adding a fibrous filter aid and a mineral powder to the liquid; then - subjecting the liquid comprising the stress protein, the (the) component (s) precipitate (s), the auxiliary of the fibrous filter and the mineral powder to a first filtration step a filter, which separates this way the precipitate, the fibrous filter aid and the filtrate mineral powder comprising the stress protein; thereafter - subjecting the filtrate to an additional filtration step; and after that - purifying the stress protein.


Experimental welding copper nozzles steelworks in Smederevo has contributed to the adoption of welding technology and provide adequate reserves with minimum cost of producing. Experimentation in the laboratory for welding process has been successfully confirmed TIG and MIG welding of dissimilar metal steel copper in the case of nozzles. Adequate preheating (select the appropriate temperature) and the corresponding additional material to a certified welders have proven that the default technology meets the needs of the welding nozzles at 100% penetration testing and testing of pressure . Keyword: welding, copper, nozzles, technology, resources, steel, methodes . ——————————  ——————————


In this gaper, we record an experiment in "big-computing" for third-year undergraduate students. This experiment was part of the Software Engineering subject (COMP321) in the Computer Science Department at the University of Newcastle. The experience was achieved through year-long programming projects from academia and industry. We discuss important surprises, benefits, and drawbacks. Our experiment was a success, but there are major areas for us to address in next year's course including providing the students with a more consistent experience and better preparation.<<ETX>>


Solar particle events that are rich in 3He typically also exhibit large overabundances of heavy and ultraheavy ions that increase with the mass of the ions. To explain these observations we apply our charge-consistent acceleration model, which takes into account the acceleration efficiency as a function of the charge to mass ratio of the ion, as well as the charge-dependent Coulomb energy losses, to consider the acceleration of ions within a wide range of their nuclear charge. Because the considerations of particle acceleration were restricted so far by tabulated values of ionization and recombination coefficients that were available only for a limited set of ions, we make use of our method developed earlier and calculate the rates of ions resembling the three representative mass groups of ultraheavy ions. We demonstrate that smaller Coulomb losses together with higher acceleration efficiency result in the enhancements of heavy and ultraheavy ions, in accordance with recent observations. We also conclude that the existing measurements of ultraheavy ions in impulsive solar energetic particle events provide evidence in favor of a magnetic turbulence in the acceleration region with spectral index S ≥ 2.


The thermal dissociation of Mg 2 Si was studied in the temperature range 715-796 K by high-temperature mass spectrometry with the use of a two-compartment effusion cell. Saturated vapor pressures of atomic magnesium were determined. The results of effusion measurements were used to calculate the enthalpy of Mg 2 Si dissociation, Mg 2 Si(s) = 2Mg(g) + Si(s), by the second and third laws of thermodynamics. The literature data on the enthalpy of formation of Mg 2 Si obtained by various experimental and theoretical methods were analyzed. The < f H°(Mg 2 Si, 298.15 K) =-66 ′ 3 kJ/mol value was recommended.


One of the most complex problem areas of broadcast programing is where a person's "right to privacy" meets the public's (or the broadcaster's) "right to know." Guidelines through this area are difficult to find, resting as they do upon a highly technical body of law. Textbooks in broadcasting suggest the broadcaster use caution whenever the right to privacy might become an issue, but fail to give clear instruction (apart from the need to obtain a release in some unspecified form) on the best methods of avoiding a law suit. The average newsman and other program production personnel are ill‐equipped to analyze a difficult legal question without help and with little time. The following article, written for a graduate seminar at Michigan State University under the direction of Dr. Walter Emery, is designed to provide the non‐lawyer broadcaster with some guides for minimizing the influence of the "right to privacy" on the "right to know."


The clinical aspects of photosensitive epilepsy are characterized predominantly by generalized tonic-clonic seizures and commonly induced by flickering lights, sunlights or television. Several animal models were reported to be equivalent to the photosensitive epilepsy; they are electrical stimulation of the visual cortex1 2, systemic application of penicillin3, systemic application of allylglycine or thiosemicarbazide following the lateral geniculate body kindling4 ci and genetic epilepsy model of Senegalese baboon Papio papio". In this report, we injected kainic acid (KA) into a unilateral visual cortex (VC) or lateral geniculate body (LGB) in freely moving cats, and electroencephalographic and clinical observations as well as an effect of intermittent photic stimulation (IPS) were studied.


The first examples of intramolecular Zr-catalyzed electrophilic alkylation of aryl olefins are disclosed. Substituted carbo- and heterocycles are prepared efficiently and diastereoselectively.


Based on the 'negative cross-resistance' phenomenon between N-phenylcarbamates and benzimidazole fungicides, the fungicidal mixture of carbendazim + diethofencarb (MBC + NPC) was introduced, to control Botrytis cinerea phenotypes which are either sensitive to benzimidazoles and resistant to NPC (wild-type: BenS NPCR). or resistant to benzimidazoles and sensitive to NPC(BenR NPCS). At one out of four sites where the MBC + NPC mixture was used in commercial cucumber greenhouses, grey mould control failed and a new phenotype of B. cinerea was found. The new phenotype was resistant to benzimidazoles, as was 100% of the population screened in the four sites, but retained resistance to NPC. Accordingly, the new phenotype was designated BenR NPCR. It was pathogenic on cucumber seedlings.


Objective: Preeclampsia is the leading cause of maternal and fetal morbidity and mortality in the United States, affecting ~2–5% of all pregnancies. Women with a history of preeclampsia have a 4-fold increased risk for developing hypertension, 2-fold increased risk for developing stroke, and 2-fold increased risk for developing ischemic heart disease later in life. Although it is known that intact renin-angiotensin-aldosterone system (RAAS) signaling is critical to a healthy pregnancy and that the RAAS is altered in preeclampsia the pathogenic mechanisms are largely unknown and a comprehensive examination of RAAS metabolism and receptor expression is lacking in the literature. The purpose of this study is to understand how the vasculature becomes refractory to the reported high circulating angiotensin II (ANGII) during pregnancy. This work provides basic information needed to understand blood pressure regulation and volume expansion in normal pregnancy, and why it fails to occur in women with preeclampsia, resulting in hypertension and fetal growth restriction. Design and method: We performed AT1 receptor autoradiography in kidneys of virgin (V) and late pregnant (LP) rats. We also performed equilibrium RAAS Fingerprinting in the plasma and kidneys of LP rats and V rats using a new LC/MS technique. Results: Using this new method, ANGII levels were decreased in the plasma and unchanged in the kidney of LP animals. This was surprising as it is inconsistent with historical data, however, other methods of measuring ANGII are problematic and often unreliable. There was a very high Aldosterone/ANGII-ratio (AA2) in both plasma and kidney of LP animals. The AA2-ratio provides information about the adrenal aldosterone-releasing response to ANGII. We also found that AT1R expression is decreased in the kidneys of LP compared to V rats. Conclusions: These results suggest a systemic down regulation of renal ANGII signaling with increased adrenal signaling. Continuing studies are assessing the RAAS signaling cascade to further validate these data, which may revolutionize the way we think about the RAAS in pregnancy, leading to improved treatment of women with preeclampsia.


We present an exact solution for a static and axially symmetric spacetime, which is obtained from a scalar-tensor theory that comes from unification theories. As an attempt to model the dark matter (DM) in spiral galaxies we find that an exponential scalar potential is enough to explain the rotation curves in such galaxies. We also present the fitting to the rotation curve of six spiral galaxies and we find an excellent agreement between observational data and the results of our model.


The authors report 43 cases with ocular signs among 60 cases of myasthenia gravis encountered over a period of 23 years in the Ophthalmologic and Neurologic clinics of the University Teaching Hospital of Dakar. After analysis of the aetiological, clinical, evolutional and therapeutic features, they insist on the importance of the ocular symptoms that eventually can help to early diagnosis and treatment.


Two hundred and seventy‐seven patients with epilepsy treated with diamox alone or in combination with other drugs have been described. All patients had been followed for at least three years.


"The drawer and the drawing" is an installation that is a direct response to the Deakin artists books collection. Using original drawing, hand colouring, computer enhanced artwork, paper-cutouts, photographs, I created a glimpse of what the "book" tells me about the artist? I created "artworks, the books and the ephemera that was left over and behind when the "artbook" was taken away and placed in a gallery.