Introduction: CC-92480 is a potent, novel CELMoD ® compound designed for rapid and maximal degradation of Ikaros and Aiolos, that has shown immunostimulatory effects and enhanced tumoricidal activity in myeloma cells, including those resistant to lenalidomide (LEN) and pomalidomide (POM). CC-92480 has demonstrated potent synergy with DEX, proteasome inhibitors (PIs), and anti-CD38 monoclonal antibodies (mAbs) (Wong L, et al. Blood 2019;134[suppl 1]:1815). In pts with RRMM, CC-92480 in combination with DEX demonstrated a manageable safety profile with promising preliminary efficacy (Richardson PG, et al. J Clin Oncol 2020;38[suppl 15]:8500). CC-92480-MM-002 (NCT03989414) is an ongoing phase 1/2 study evaluating CC-92480 in combination with standard treatments in pts with RRMM. Here we report preliminary results from the CC-92480 + BORT + DEX cohort.
 Methods: Pts with RRMM who had received 2-4 prior regimens, including prior treatment with LEN, and had documented disease progression during or after their last myeloma therapy were eligible. CC-92480, at specified cohort doses (0.3 mg, 0.6 mg, and 1.0 mg), was administered orally on days (D) 1-14 with subcutaneous BORT (1.3 mg/m 2) on D1, 4, 8, and 11 in cycles (C) 1-8 and on D1 and 8 after C8, over a 21-day cycle; DEX (20 mg/day or 10 mg/day if > 75 years of age) was given on D1, 2, 4, 5, 8, 9, 11, and 12 in C1-8 and on D1, 2, 8, and 9 after C8. Primary objectives were to determine the maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), and to evaluate safety and preliminary efficacy. Pharmacodynamics (PD), Ikaros/Aiolos protein levels, and immunophenotyping were also assessed.
 Results: As of May 26, 2021, 19 pts had received CC-92480 + BORT + DEX. Median age was 66 (50-83) years, median time since initial diagnosis was 4.8 (1.9-17.1) years, and median number of prior regimens was 3 (2-4). Prior therapies included stem cell transplantation (57.9%), BORT (78.9%), carfilzomib (CFZ, 21.1%), LEN (100%), POM (47.4%), and anti-CD38 mAbs (36.8%); 21.1% of the pts had extramedullary disease and 21.1% were triple-class refractory (refractory to immunomodulatory drug, PI, and anti-CD38 mAb). Median follow-up was 8 (1.0-19.2) months, with a median number of 10 (1-28) cycles received and 9 (47.4%) pts continue on treatment. Main reason for discontinuation was progressive disease, reported in 5 pts.
 All pts experienced ≥ 1 treatment-emergent adverse events (TEAEs) and grade (Gr) 3-4 TEAEs were reported in 18 (94.7%) pts. Most frequent (≥ 10% of pts) Gr 3-4 TEAEs were neutropenia (36.8%, no febrile neutropenia reported), thrombocytopenia (21.1%, no bleeding reported), anemia (10.5%), hyperglycemia (10.5%), and insomnia (10.5%). Gr 3-4 infection was reported in 1 (5.3%) pt. Eight (42.1%) pts had Gr 1-2 peripheral neuropathy. Five (26.3%) pts had serious TEAEs, none considered related to study treatment. Five (26.3%), 7 (36.8%), and 8 (42.1%) pts had dose reductions of CC-92480, BORT, and DEX, respectively; 4 (21.1%) pts had dose reductions due to TEAEs. Two (10.5%) pts discontinued due to TEAEs (dysgeusia and colon neoplasm [pre-existing]). No pt experienced dose-limiting toxicity and the MTD was not reached. Two deaths were reported (due to myeloma progression and colon neoplasm).
 The overall response rate across all doses per investigator assessment was 73.7% (14/19 pts), including 3 stringent complete responses and 1 complete response. Responses were observed at all dose levels. Median duration of response was 10.4 (5.5-not reached) months and median time to first response was 0.95 (0.7-3.3) months.
 Plasma exposures of CC-92480 + BORT + DEX were consistent with previous pharmacokinetic (PK) analysis of CC-92480 + DEX. Consistent with CC-92480 mechanism of action, PD studies showed potent degradation of substrates 3-6 hours post treatment and a reduction of mature B cells with CC-92480 + BORT + DEX treatment.
 Based on safety, efficacy, and PK/PD data, a 1.0 mg dose of CC-92480 was selected as the RP2D.
 Conclusions: CC-92480 in combination with BORT and DEX appears to be safe and well tolerated with encouraging preliminary efficacy in pts with RRMM. These results support further development of CC-92480 in combination regimens in RRMM. In the CC-92480-MM-002 study, a CC-92480 + BORT + DEX expansion cohort is ongoing at the RP2D, as well as a CC-92480 + CFZ + DEX cohort. Updated data will be presented at the meeting.

 Richardson: Secura Bio: Consultancy; GlaxoSmithKline: Consultancy; Takeda: Consultancy, Research Funding; Janssen: Consultancy; AstraZeneca: Consultancy; Regeneron: Consultancy; Sanofi: Consultancy; Oncopeptides: Consultancy, Research Funding; Celgene/BMS: Consultancy, Research Funding; Karyopharm: Consultancy, Research Funding; Protocol Intelligence: Consultancy; AbbVie: Consultancy; Jazz Pharmaceuticals: Consultancy, Research Funding. Ocio: Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria, Speakers Bureau; Janssen: Consultancy, Honoraria, Speakers Bureau; Amgen: Consultancy, Honoraria; Bristol-Myers Squibb/Celgene: Consultancy, Honoraria; Karyopharm: Consultancy; MSD: Honoraria; Oncopeptides: Consultancy, Honoraria; Pfizer: Consultancy; Secura-Bio: Consultancy. Raje: Caribou: Other; Janssen: Other; bluebird bio: Other; Amgen: Other; Celgene: Other; BMS: Other. White: Amgen: Consultancy, Honoraria; Antengene: Consultancy, Honoraria; BMS: Consultancy, Honoraria; Forus: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; GSK: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Karyopharm: Consultancy, Honoraria. Oriol: Sanofi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Karyopharm: Consultancy, Membership on an entity's Board of Directors or advisory committees; GSK: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Oncopeptides: Consultancy, Membership on an entity's Board of Directors or advisory committees; BMS/Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees. Sandhu: Celgene/BMS: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Gilead: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria. Raab: Sanofi: Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees; Roche: Consultancy; Novartis: Membership on an entity's Board of Directors or advisory committees, Research Funding; GSK: Honoraria, Membership on an entity's Board of Directors or advisory committees; Abbvie: Consultancy, Honoraria; Janssen: Membership on an entity's Board of Directors or advisory committees; BMS: Consultancy, Membership on an entity's Board of Directors or advisory committees; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees. LeBlanc: Amgen Canada: Membership on an entity's Board of Directors or advisory committees; Sanofi Canada: Membership on an entity's Board of Directors or advisory committees; Janssen Canada: Membership on an entity's Board of Directors or advisory committees; BMS/Celgene Canada: Membership on an entity's Board of Directors or advisory committees; Celgene/BMS: Research Funding; Takeda Canada: Membership on an entity's Board of Directors or advisory committees. Rodriguez: BMS: Consultancy, Speakers Bureau; Janssen: Consultancy, Speakers Bureau; Takeda: Consultancy, Speakers Bureau; Oncopeptides: Consultancy, Honoraria; Amgen: Consultancy, Speakers Bureau; Karyopharm: Consultancy, Speakers Bureau. Trudel: Sanofi: Honoraria; Roche: Consultancy; GlaxoSmithKline: Consultancy, Honoraria, Research Funding; Pfizer: Honoraria, Research Funding; Genentech: Research Funding; BMS/Celgene: Consultancy, Honoraria, Research Funding; Janssen: Honoraria, Research Funding; Amgen: Honoraria, Research Funding. Wäsch: Pfizer: Consultancy; Amgen: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Novartis: Consultancy; BMS/Celgene: Consultancy; Gilead: Consultancy. Perrot: Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees; GSK: Honoraria, Membership on an entity's Board of Directors or advisory committees; Sanofi: Honoraria, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Abbvie: Honoraria. Bahlis: BMS/Celgene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Karyopharm: Consultancy, Honoraria; Genentech: Consultancy; Amgen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Abbvie: Consultancy, Honoraria; GlaxoSmithKline: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria. Zhou: Bristol Myers Squibb: Current Employment, Current equity holder in publicly-traded company. Lamba: Bristol Myers Squibb: Current Employment; Pfizer: Current equity holder in publicly-traded company. Amatangelo: Bristol Myers Squibb: Current Employment, Current equity holder in publicly-traded company. Civardi: Bristol Myers Squibb: Current Employment. Katz: Bristol Myers Squibb: Current Employment, Current equity holder in publicly-traded company. Maciag: Bristol Myers Squibb: Current Employment, Current equity holder in publicly-traded company. Peluso: Celgene, a Bristol-Myers Squibb Company: Current Employment. Dimopoulos: BMS: Honoraria; Janssen: Honoraria; Beigene: Honoraria; Takeda: Honoraria; Amgen: Honoraria.


The influence of superconducting energy gap on the performance of single electron transistor as electrometer has been studied and was found out to improve its charge sensitivity. This paper mainly deals with 1-D (dimensional) HTS mesoscopic tunneling junction array made up of HTS material Tl-1223 with capacitively coupling to a ground plan. The layered nature of Tl-1223 acts as ideal SIS junctions. The influence enforced by the superconducting energy gap on the static and dynamics of such an array is studied numerically based on the "Orthodox Theory" of single electronics. The charge transfer in the means of solitons introduced by the voltage source attached to the end of the array is also discussed.


Focusing on the solution physical chemistry and surface properties of cationic surfactants, three major sections examine the properties of cationic surfactants themselves both in solution and at interfaces, the interactions of cationic surfactants with other materials, and applications of cationic s


Based on concentration probability of estimators about a true parameter, third-order asymptotic efficiency of the first-order bias-adjusted MLE within the class of first-order bias-adjusted estimators has been well established in a variety of probability models. In this paper we consider the class of second-order bias-adjusted Fisher consistent estimators of a structural parameter vector on the basis of an i.i.d. sample drawn from a curved exponential-type distribution, and study the asymptotic concentration probability, about a true parameter vector, of these estimators up to the fifth-order. In particular, (i) we show that third-order efficient estimators are always fourth-order efficient; (ii) a necessary and sufficient condition for fifth-order efficiency is provided; and finally (iii) the MLE is shown to be fifth-order efficient.


In (I), the following error occurred. The list of authors for Reference 8 is incorrect. The correct reference details should be as follows: Terheyden P, Hofmann MA, Weininger M, Br€ ocker EB, Becker JC. Anti-vascular endothelial growth factor antibody bevacizumab in conjunction with chemotherapy in metastasising melanoma. J Cancer Res Clin Oncol. 2007 Nov; 133(11):897-901. Epub 2007 Jun 22. (I) Molina-Ruiz, A. M., Domine, M. and Requena, L. (2013), Acute and severe acne in a patient treated with bevacizumab. International Journal of Dermatology, 52: 486–490. doi: 10.1111/j.1365-4632.2012.5658.x


Abstract Ethnohistorical and archaeological data suggest that a collection of more than 450 finely worked Inka building stones found near Saraguro in the southern highlands of Ecuador originated outside that region. The origin of those andesite blocks was investigated via geochemical analysis. Wavelength-dispersive X-ray fluorescence determined the concentrations of nine elements in samples from stones in the Saraguro region and in samples from known Inka andesite quarries at Cojitambo in the southern sierra of Ecuador, and at the Rumiqolqa and Huaccoto quarries near the Inka capital of Cuzco in Peru. The results show that the geochemical composition of the Saraguro stones closely matches that of the Rumiqolqa material, indicating that the Inka had these large andesite blocks moved over a distance of more than 1,600 km, the greatest known distance for the transport of large objects in the precolumbian New World. This endeavor had many implications, including reinforcing state power and ideology, and is also perceived to reflect an imperial "made-work" policy that consumed excess labor through non-utilitarian assignments. These "made-work" projects are best explained as a strategy for reinforcing state control over subject provinces, in contrast to current models of Inka economic organization that focus on efficiency in the use of labor.


This study aims to investigate the thermal conditions of the molds, changes in microstructure and hardness of casting products using sand mold and permanent mold. The use of sand mold and permanent mold results in different cooling rates. Thermal analysis was performed using a thermocouple to obtain a temperature versus time curve. Metallographic observations were carried out using a Scanning Electron Microscope equipped with Energy-Dispersive X-ray Spectroscopy. The Vickers hardness test was carried out in three areas with different thicknesses. The results showed a constant temperature at 691 oC where the eutectoid phase reaction occurred. Testing with sand mold showed that cast iron with flake graphite was finer and spreader than graphite in cast iron produced by permanent mold. Meanwhile, gray cast iron from a casting process with a permanent mold has a higher hardness than gray cast iron from a casting process using a sand mold.


This thesis consists of an exhibit, Cannery Days A Chapter In The Life Of The Heiltsuk which opened at the University of British Columbia's Museum of Anthropology (MOA) in May 1993, and a written paper which discusses the processes and political issues involved in doing an exhibit on a subject that is not only complex, but poorly understood by the general public. The context of the exhibit and this paper is the failure of non-Native society to understand that fish were and continue to be the economic wealth of B.C. First Nations. Within this context, the related issue of the invisibility of First Nations women and men in the fish-processing industry is addressed through the exhibit using quotes, photographs, and text. The exhibit and this subsequent paper grew out of concern and unease about how First Nations and their relationship with fish have traditionally been presented in academic literature. The purpose of this thesis is to tell how my knowledge of the traditional fisheries, and my experience in the fishing and fish-processing industries, in combination with my training in the discipline of anthropology has been put to use in preparing an exhibit to tell about Heiltsuk people and fish. It will discuss the exhibit as a medium or bridge which allowed me to illustrate this relationship without diminishing the lives and experiences of Heiltsuk people. Interviews with seventeen Heiltsuk women, four Heiltsuk men and one long-time employee of B.C. Packers open a window on a period of history which has not been well documented. To read conventional accounts of Native involvement in the fish-processing industry, their lives were grey and dreary. The exhibit reveals that for the people who lived and worked in Namu, it was not just a place to work, it had many meanings and warm


Reagan's Caribbean Basin Aid Programme A Military Policy in Search of an Economic Rationale PRESIDENT Reagan's programme for economic development in what is now dubbed the Caribbean Basin is constructed on a set of assumptions that have little relation to historical or contemporary reality. The economic programme will neither contribute to develop the region nor reduce the level of political and social warfare. Basically, it not only fails to come to grips with the deep structural features that engender conflict, but its assumptions concerning the relationship between politics and development, the state and market are fundamentally flawed. Ultimately, the presentation of the economic package, while couched in the pragmatic language of concern for economic development is a rationale for greater military involvement The likely failure of the programme, the incapacity of the economic proposals put forth to deal with the major economic and social issues will establish the groundwork for straightforward military solutions. The failures will be attributed to subversion


Resumen en: Very little information is available with respect to dynamic aspects of oocyte development and to yolk composition of tuna species. Since histological a...


Demand response management (DRM) is envisaged to play a key role in the smart grid operation, which requires reliable communications between power providers and consumers. To reduce communication cost, the cognitive radio technique is proposed to transmit the meter data from consumers to the control center. Unlike most existing studies on cognitive enabled smart grid, where only individual spectrum sensing is considered, in this paper, both cooperative spectrum sensing and harvested renewable energy are incorporated. The tradeoff between spectrum sensing cost and the DRM management gain makes the optimization of cooperation scheme a challenging research problem. To solve the problem, we analytically study the degradation of communication reliability of the renewable energy supplied consumers who attend the cooperative sensing as well as the DRM gain obtained by the communication improvement. Further, the optimization problem of selecting the number of cooperative consumers is formulated. We prove that there exists a unique optimal cooperative number under some constraints and propose an efficient searching algorithm. Numerical results are presented to validate our theoretical analysis.


For momentum wheel product's development and lifetime assessment,the physical fail- ure model test is conducted.Because the momentum wheel failure is represented as the failure of its bearing assembly lubrication system,the bearing assembly is selected as the test model.In this paper,we has analyzed the real working environment of momentum wheel bearing assembly, determined the ground simulation specification of the test model,then the effecting factors of bear- ing assembly lubrication system failure are analyzed,after that to determine the sampling scheme. Finally,the mathematical presentation of the failure of bearing assembly lubrication system is given. For the assurance of momentum wheel product lifetime assessment,it is believed to produce two important tribology matching tests during production is necessary.


Physical activity plays an important role in tissue anabolism, growth, and development. It is now wellestablished that mechanisms that link patterns of exercise with tissue anabolism are related to anabolic and catabolic hormonal adaptations. This is particularly important during childhood and adolescence since many exerciseassociated hormonal effects are ageand maturity dependent. Levels of physical activity are significantly higher during childhood, and adolescence is characterized by a substantial increase in muscle mass and strength. Thus, the combination of rapid growth and development, high levels of physical activity and spontaneous pubertyrelated increases in anabolic hormones (eg, growth hormone, insulin-like growth factor-I and sex steroids) suggests the possibility of integrated mechanisms linking exercise with a variety of hormonal responses. On the other hand, participation of young athletes in intense competitive training, especially if associated with inadequate caloric intake, may lead to several health hazards, and may be associated with attenuation of several hormonal axes, such as the GH-IGF-I axis and the hypothalamic-pituitary-gonadal axis. Moreover, in recent years the evaluation of the anabolic-catabolic hormonal response to acute exercise bouts and prolonged training periods was suggested as a possible objective tool for the assessment of the training load in young elite athletes (4). Most importantly, the endocrine effects of exercise and training are not limited to individuals participating in competitive sports since a substantial hormonal stimulus arises even from the relatively modest physical activity of daily living. In addition, exercise plays an important role in the management and treatment of several relatively common endocrine diseases like type 1 diabetes, bone disorders and the epidemic of childhood obesity. Therefore, the unique childhood-exercise-endocrine relationship has gained a lot of scientific interest in recent years and was the basis for the publication of the current special issue. It is not surprising, therefore, that this "Endocrinology and Pediatric Exercise Science" special issue includes reviews as well as original articles that cover all these topics. Manuscripts related to the healthy child include reviews on exercise, hormones, and skeletal adaptations during childhood and adolescence (7) and adipocytokine and ghrelin responses to acute exercise and sport training in children during growth and maturation (8). Manuscripts related to the child and adolescent athlete include reviews on hormonal response to resistance training in children and adolescents (6), the effect of hormonal performance-enhancing substances in children and adolescents (10), a summary of the GH-IGF-I response to typical field sport practices in adolescent athletes (3), body composition and adypocytokines in rhythmic gymnasts (14), hormonal and metabolic response differences to a single exercise bout between young and adult athletes (5), and finally the intriguing possible use of hormonal genetic polymorphism in the identification and selection of young elite athletes (1). Manuscripts related to common pediatric endocrine diseases include reviews on exercise and type 1 diabetes (13) as well as original articles on altered insulin response to acute exercise in pediatric obesity (12), hormonal responses to resistance exercise in obese children (11), the effect of aerobic exercise on hunger and satiety regulating hormones in obese adolescent girls (9) and the association between physical activity and insulin resistance in children treated with anti-psychotic medications (2). As a guest editor of this special issue, I am profoundly grateful to all authors who contributed to the final outcome of "Endocrinology and Pediatric Exercise Science" and to the current editor of Pediatric Exercise Science for the opportunity and privilege of editing this issue. I hope that this special issue will stimulate further research in this constantly challenging and exciting field.


Abstract A recent Spanish law for the reform of secondary education (LOGSE) contains a series of provisions designed to arouse interest in other cultures, to increase awareness that people do not emigrate in search of pleasure or as part of a premeditated invasion, and to promote tolerance as a guiding principle for life in the community. In keeping with these new requirements, a computer game based on a fictional plot has been designed in which the players find the information they need by questioning a series of characters one by one. Their mission is to guess a mystery sentence (the enigma) and to answer the questions on a sheet they receive at the start of the game. The characters tell the students about their lives and customs and about what it felt like to leave their homeland. They also help them to answer the questions and find the mystery sentence.


ABSTRACT The mammalian oocyte nucleolus, the most prominent subcellular organelle in the oocyte, is vital in early development, yet its key functions and constituents remain unclear. We show here that the parthenotes/zygotes derived from enucleolated oocytes exhibited abnormal heterochromatin formation around parental pericentromeric DNAs, which led to a significant mitotic delay and frequent chromosome mis-segregation upon the first mitotic division. A proteomic analysis identified nucleoplasmin 2 (NPM2) as a dominant component of the oocyte nucleolus. Consistently, Npm2-deficient oocytes, which lack a normal nucleolar structure, showed chromosome segregation defects similar to those in enucleolated oocytes, suggesting that nucleolar loss, rather than micromanipulation-related damage to the genome, leads to a disorganization of higher-order chromatin structure in pronuclei and frequent chromosome mis-segregation during the first mitosis. Strikingly, expression of NPM2 alone sufficed to reconstitute the nucleolar structure in enucleolated embryos, and rescued their first mitotic division and full-term development. The nucleolus rescue through NPM2 required the pentamer formation and both the N- and C-terminal domains. Our findings demonstrate that the NPM2-based oocyte nucleolus is an essential platform for parental chromatin organization in early embryonic development. Summary: The oocyte nucleolus is successfully reconstituted by NPM2 protein, and serves as a key platform to organize pericentromeric heterochromatin in order to correctly segregate parental chromosomes.


In this article, design of a microstrip ring‐like diplexer for Bluetooth and ultrawide band application is presented. Two ring‐like bandpass filters, operated at 2.4 and 4 GHz, are combined together to form the proposed microstrip diplexer. Several transmission zeros located at the passband edges are introduced to improve the passband selectivity. High isolation between the two passband greater than 28 dB is achieved in this study. The designed diplexer is investigated numerically and experimentally. Measured results show a good agreement with the simulated analysis. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1518–1520, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24358


In the history of modern trade theory, the capitalized countries set up ridiculous pretensions as specialization for being an industrialized country. Thus, well-know words according to their idea is "Africa has a strong comparative advantage in natural resources, so, they should specialize on them." But today, new theories on over-specialization are to keep away commodity dependent countries from specialization. As mentioned above, there are many new concepts which are not available for Africa continent. In this article, new concepts such as Natural Curse Arguments (paradox of plenty), Dutch Disease, Immiserising Growth, windfall gain argument and over-specialization were discussed.


In response to the complexities of Physical Related Specialities for College Entrance Examination in the examination organization and score processing, a comprehensive management information system was developed by Jiangsu Provincial Education Examination Authority. The system provides technical supports to make sure the examination implementing standardized and effectively. This paper summarizes the functional structure, business process, system architecture, key functions, and applications of the system, which could be used as a reference for other provinces to build their own examination management system of physical related specialities for College Entrance Examination.


Objectives: This biomechanical study seeks to define the relative effectiveness of contemporary single and dual implant constructs for fixation of an extra-articular proximal tibia fracture model. Methods: An extra-articular proximal tibia fracture model was created using synthetic tibias. Four constructs were tested. Constructs included (1) lateral locked plate (LLP), (2) intramedullary nail (IMN), (3) combined LLP and IMN (PN), and (4) LLP and medial locked plate. Specimens were axially loaded through the medial plateau to evaluate construct stiffness and the ability to resist varus collapse. Results: Dual implant constructs were stiffer than single implant constructs in this model. Although DP and PN were stiffer than IMN at all loads tested, the difference was notable only for DP at higher loads. Isolated LLP provided insufficient stability to be tested at higher loads. Conclusion: Dual plate fixation provides the greatest resistance to varus collapse. In the clinical setting, consideration must be given to the fracture morphology, desired construct stiffness, and soft-tissue envelope in selecting the optimal construct to be used.


In this work we present an algorithm used to automatically register a sequence of ladar images taken from a sensor flying a known flight path . The registration is performed with no human operator intervention. The resulting mosaic is accurate to one pixel. The algorithmic approach was developed in such a way to allow for near real time processing. The initial method can be extended to registration of multiple views of a scene, with four degrees of freedom (translation and in plane rotation). In this work we will restrict ourselves to rigid body transformations. The registered mosaic is an important step in geolocation using a reference digital elevation map, and will be explored in future work.


In real-time mode, some kinds of error corrections for GPS pseudo-rang are given in the paper, i.e. tropospheric refraction delay, ionospheric refraction delay, earth-rotating correction, relativity effect, satellite antenna eccentricity, solid tide correction. Based on experiments of single frequency point positioning, each way of correction has been analysed in this paper. Finally,give out the accuracy of point positioning.


Synthesis from a different perspective - how nature does it overview of carotenoid biosynthesis molecular biology of carotenoid biosynthesis degraded carotenoids carotenoids in chemosystematics metabolism of carotenoids in mammals absorption and metabolism of carotenoids in birds, fish and crustaceans carotenoids in food chains guidance on practical strategies and procedures


Debris flows in the Wudongde dam area, China could pose a huge threat to the running of the power station. Therefore, it is of great significance to carry out a susceptibility analysis for this area. This paper presents an application of the rock engineering system and fuzzy C-means algorithm (RES_FCM) for debris flow susceptibility assessment. The watershed of the Jinsha River close to the Wudongde dam site in southwest China was taken as the study area, where a total of 22 channelized debris flow gullies were mapped by field investigations. Eight environmental parameters were selected for debris flow susceptibility assessment, namely, lithology, watershed area, slope angle, stream density, length of the main stream, curvature of the main stream, distance from fault and vegetation cover ratio. The interactions among these parameters and their weightings were determined using the RES method. A debris flow susceptibility map was produced by dividing the gullies into three categories of debris flow susceptibility based on the susceptibility index (SI) using the FCM algorithm. The results show that the susceptibility levels for nine of the debris flow gullies are high, nine are moderate and four are low, respectively. The RES based K-means algorithm (RES_KM) was used for comparison. The results suggest that the RES_FCM method and the RES_KM method provide very close evaluation results for most of the debris flow gullies, which also agree well with field investigations. The prediction accuracy of the new method is 90.9%, larger than that obtained by the RES_KM method (86.4%). Therefore, the RES_FCM method performs better than the RES_KM method for assessing the susceptibility of debris flows.


81 Although a large number of empirical studies have investigated the international transmission of the global financial crisis (GFC) (Claessens et al., 2010; Cetorelli and Goldberg, 2011; Chudik and Fratzscher, 2011; Haas and Lelyveld, 2014; Chen et al., 2016), the literature is still unable to provide conclusive results on the determinants of crisis severity in different transition countries (Berglöf et al., 2009; Berkmen et al., 2009; Blanchard et al., 2010; Lane and Milesi-Ferretti, 2011; Rose and Spiegel, 2009a, 2009b, 2011). This study aims to enhance knowledge in this area by providing analyses of the international transmission of shocks to European transition countries, employing the global vector autoregression (GVAR) approach developed by Pesaran et al. (2004). A distinguishing feature of the recent GFC was the speed and synchronicity with which it spread around the world. The European transition countries were severely affected by the GFC with an average GDP decline of around 7% in 2009, experiencing a more severe impact than any other region in the world, including the EU-15, where output decline averaged 5% in 2009. The impact of the crisis on economic activity varied extensively across countries. Slovenia, Croatia, Romania and the Baltic countries were more severely affected by the GFC, with 2009 output


Measurements and Results: The medical records of 16 patients, with diagnosis of BOOP made by open lung biopsy specimen, were reviewed and the data collected included demographic information, underlying disease, clinical, radiological, and pathological manifestations, pulmonary function tests, arterial blood gases, methods of diagnosis, treatment and final outcome. We found that the mean age of our BOOP population was 47 years (range 15-77); the female/male ratio was 9/7 and except one all of them were Caucasian. The most common underlying neoplasia was Lymphoma. Five of them presented with symptoms such as dyspnea and cough, but 3 were asymptomatic. Five had crackles upon auscultation. The predominant physiological abnormality was a decline in diffusing lung capacity and hypoxemia. Four patients presented with patchy infiltrates, 2 with nodules, 1 with mass, and 1 with localized hyperinflation. From the 14 patients in whom some form of treatment was attempted, 2 responded favorably to corticosteroids, 1 did not and died, 2 improved temporarily but ultimately died, 1 improved with antibiotics, and in 2 improved spontaneously.


A question we routinely hear in our workshops is, " How can we get students to read before class? " The ques-tioners have a perfectly natural desire not to waste class time on material they think students can just as easily get for themselves, and when later most of their students seem to have no clue about the readings, they conclude that the students must be lazy or illiterate. Some may be, but that's not generally the problem. Assignments intended to introduce new material can be effective or worthless or anything in-between. The best ones are interactive multimedia tutorials that provide affirmation or corrective feedback in response to students' inputs. Less effective but still acceptable are videos of well-delivered lectures with lots of visual content, demonstrations, and examples. Such resources can equip most students to come to class ready to work, and if the tutorials and videos are particularly well designed the instructor may flip the classroom, abandoning lecturing completely and devoting the entire class time to problem-solving and project work. On the other hand, simply assigning textbook readings to introduce new material is generally futile. STEM texts tend to be dense, dry, and almost indecipherable to anyone without superior reading skills, which relatively few people have. To get anything but vague general ideas from them, students would have to read them painstakingly, making sure they understand definitions, explanations, steps in derivations, and meanings of diagrams and plots before moving on, and it would normally take several passes to get a reasonable level of understanding. Most of our students don't know how to read that way—it's not self-evident and no one ever taught them to do it. Being rational, once they find their text incomprehensible they ignore it. Hobson [1] cites studies showing that over 70% of students in classes in all subjects ignore reading assignments, and the percentage is undoubtedly higher in STEM courses. Instead of introducing challenging new material in reading assignments, consider doing it in class using a blend of lecturing and active learning, [2] focusing the activities on the more difficult concepts and methods being presented; then give assignments that clarify, expand on, and require application of the material introduced in class. You will cover the same content that you would if you gave the readings first, but with the initial guidance they get in class, the students will be much more likely to understand it. …


Newton's method is used to calculate approximately the roots of any complex or real valued function consists iteration. For each complex polynomial ) (z P , Newton's method defines a dynamical system on the complex Riemann sphere. The our goal is to prove that any quartic polynomial with at least two distant roots topologically conjugate to  N and any two polynomials with roots has a similar quartic shape then the Newton function for each polynomial are conjugate. Finally ,we study the symmetry of Newton's function with real and complex axis. The software MatLab will use to view the dynamics of quartic polynomial after the iterations of Newton's method. The graphical nature of the iterations gave us very nice properties that allow us to describe the behavior of the points in the plane. 1-Introduction Newton's method is one of the preferred methods to find roots of differentiable function, Newton's method defines a dynamical system. If consists of iterating the function ) (z f then ) ( ) ( ) ( z f z f z z N    By starting with an initial approximation, 0 z , sufficiently close to the root of ) (z f ,the sequence of iterates, ) ( 1 n n z N z   , will converge to the root[1]. The study of iterated maps is the study of the dynamics of orbits of points under repeated composition of a function with itself[2].If the function ) (z f is polynomial ,then the iteration function ) (z N will be a rational function of the form, ) ( ) ( ) ( z Q z R z N  Where ) (z R and ) (z Q are polynomials with real of complex coefficients [1]. The global study of Newton's method can now be analyzed using the The Dynamics of Newton's Method on Complex Quartic Polynomial ..... Dr.Hussein Jaber Abdul Hussein ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ل ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةلجه دذع ىوعبس و يد ح 3122 82 theory of the complex dynamics of rational functions on the Riemann sphere ( } {   C C  ). Any complex analytical function will decompose the plane into two complementing sets, the stable set , where the dynamics are mostly tame, and the unstable set ,where the dynamics become chaotic and unpredictable [3]. The study of this idea was started by G. Julia and P. Fatou in the 1920[3],[4]. The orbit of a point 0 z is the set of iterates )),...} ( ( ), ( , { ,...} , , { 0 0 0 2 1 0 z N N z N z z z z  . The point z is a fixed point of ) (z N if z z N  ) ( , for Newton's method applied to a polynomial ) (z P , each root of ) (z P will be a fixed point of ) (z N ,and these will be the only finite fixed points. If ) (z P is not degree one, then  will also be a fixed point of ) (z N [1]. The point z is periodic point if z z N t  ) ( , for some positive integer t . The least such integer t is called the period and the orbit of z is a t-cycle [1]. In the Newton's method ,we would like our initial point 0 z to converge to the fixed point that root. The certainly happens most of the time ,but other things can happen. The orbit of 0 z could converge to a tcycle, or it could wander chaotically about the Riemann sphere [3]. If z is periodic point of period t , then the derivative ) ( ) ( z N t    is called the eigenvalue of the periodic point z . It follows from the chain rule that  is the product of the derivatives of ) (z N at each point on the orbit of z . A periodic point z classified as : superattracting if 0   ; attracting if 1   ; repelling if 1   ; and neutral if 1   [2]. The Julia set is the set of points whose orbits have unpredictable or chaotic behavior. We define the family of functions {f } n to be normal on U if every sequence of n f has a subsequence that either converges uniformly on compact subsets of U or converges uniformly to  on compact subsets of U . The Julia set, J, of f is defined to be the set of all points for which the family of iterates {f } n is not normal at z [5].equivalently, the Julia st of a rational map is equal to the closure of the set of repelling periodic points.. the Fatou set or stable set is the complement of the Julia set [4]. If we are interested in dynamics of ) (z N on the Riemann sphere, we can always conjugate ) (z N by invertible linear fractional (Mobius) transformationT , and the dynamics of the iterates of ) (z N ill be same as the iterates of 1  T N T   [1]. A Mobius transformation is a rational map of The Dynamics of Newton's Method on Complex Quartic Polynomial ..... Dr.Hussein Jaber Abdul Hussein ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ل ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةلجه دذع ىوعبس و يد ح 3122 83 the form 0 , ) (      bc ad d cz b az z T , where we have the usual convention that      ) ( , ) ( c d T c a T ,for more details see [4],[6]. From the properties of the Fatou and Julia sets we saw that they were compliments of one another of one another ,and the Julia set was the boundary for the points that converge that those that do not [3],[7] . Since the dynamics of quartic polynomials are more complicated than that quadratics and cubic polynomials which study in [1],[3] .we shall be relying more on computer graphics to illustrate their behavior and help give us a better understanding of what is actually happening. The conclusions for quadratics were somewhat easily obtained, and would be ideal if the same approach could be taken for quartic, along with getting the same sort of results. However ,the global conditions of the dynamics of  N seem to be much more complex .we will assign a coloring scheme to the points on the dynamical plane and use it for part of our investigation. we do not want to get ahead of ourselves thus we are going to develop idea like those in [3] for quartic polynomial. The main results of this paper are prove the following propositions. Proposition(1-1) : For any complex quartic polynomial P with at least two distinct roots, p N is to topologically conjugate to  N for some C   . Proposition (1-2): If ) (z p and ) (z q are quartic polynomials whose roots similar quadrate shape p S and q S , respectively then p N is conjugate to q N via some affine map. Proposition (1-3): If R   , then  N is symmetric with respect to the real axis. We also will be studying the types of graphs one would get if they looked at these same Newton's function in the complex plan. 2-Newton's Method on Complex Quartic Polynomial Let ) (z P be a fourth degree complex polynomial (Quartic Polynomial) 0 1 2 2 3 3 4 4 ) ( a z a z a z a z a z P      with four roots .it is also known that we can view this same polynomial in terms of its roots ,if we first factor out 4 a ,we now have ) )( )( )( ( ) ( 4 d z c z b z a z a z P      where d c b a , , , are roots of ) (z P [3].Newton's method on any general quartic polynomial C C P    : that has at least two distinct root is ) ( ) ( ) ( z P z P z z N p    The Dynamics of Newton's Method on Complex Quartic Polynomial ..... Dr.Hussein Jaber Abdul Hussein ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةة ل ةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةةلجه دذع ىوعبس و يد ح 3122 84 To simplify the understanding of the dynamical properties of Newton's Method on quartic polynomials, we will utilize the oneparameter family ) 1 )( 1 )( )( ( ) (      z z z z z p    rather than ) (z P itself. This still contains quartic with at least two distinct roots, and we will refer to the function created after applying Newton's method as  N . This is defined by z z z z z N 2 3 2 2 2 4


The holy month of Ramadan is a month that is highly anticipated by the people of Indonesia. We can find various kinds of messages during the Holy Month of Ramadan. This certainly encourages many people to compete to present unique and creative messages, one of which is by using advertising media. One of the food categories that uses television as marketing media is syrup products. They are competing to make an advertisement that is interesting and of course unique so that it can attract the interest of the wider community. In 2017-2020, ABC became one of the syrups that Indonesians are interested in. The advertisement that is currently appearing, namely the ABC syrup ad 'Berbagi Rasa Kebersamaan Dibulan Ramadhan' will be examined using John Bateman's multimodal semiotics using interpretive qualitative methods. Through this research, the meaning contained in the advertisement namely concern for fellow family. Therefore, this research can be seen how the ABC syrup advertisement promotes its products as a brand that cares about the moment of Ramadan in the advertisement of Sharing the Feelings of Togetherness in the Month of Ramadan.


We studied deep inelastic multinucleon transfer reactions in collisions of 64Ni+207Pb and 48Ca+238U at energies around the Coulomb barrier. The experiments were performed at the velocity filter SHIP at GSI Darmstadt. One of the goals was to investigate if deep inelastic transfer is superior to fragmentation reactions for producing neutron-rich isotopes in the astrophysically interesting region of nuclei along the magic neutron number N = 126. With both collision systems, rather neutron-rich transfer products were populated, some of them reaching out to the limits of the present chart of nuclides. New isotopes could not be identified. A comparison of the measured transfer cross-sections and yields with those from fragmentation reactions allowed for interesting conclusions.


With the increasing fierce competition of the commercial retail enterprises,commodity promotion has become an important way for them to exist.While in recent years,these enterprises have to confront the growing safety accidents caused by promotion.It is held in this paper that while they are in pursuit of profits,they must consider social safety responsibilities.This article attempted to put forward some constructive ideas based on analyzing the present situations of retail enterprises' safety management in promotion,which would be helpful for their healthy development.


ABSTRACT Opuntia ficus-indica: (OFI) cladode mucilage was extracted using conventional extraction (CE) and ultrasound-assisted extraction (UAE), to test its effect on the efficiency of electrocoagulation-electroflotation (EC-EF) water treatment process. The mucilage was identified by biochemical assays, by scanning electron microscope analysis (SEM), and by Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). The results showed that the UAE enhanced mucilage extraction yield. At 10 min of extraction time, the extraction yield attained 60.77 ± 1.07% at 60% of the amplitude sonication, while CE allows only 36.71 ± 1.07% after 60 min at 80 ⁰C. EC-EF mucilage-assisted process enhanced turbidity removal efficiency by 30% at 15 min of treatment time. Mucilage identification showed a bio-material, of a polysaccharide nature, with several functional groups through SEM, biochemical essays and ATR-FTIR, respectively. The addition of 5 mg/L OFI mucilage to EC-EF allowed 89.47% of EC-EF efficiency at 25 min.


We demonstrate several building blocks of true-time-delay (TTD) network, including subwavelength grating couplers, photonic crystal waveguide TTD lines, and multimode interferometer (MMI) power splitters fabricated on silicon nanomembrane (SiNM) transferred onto unconventional substrates, such as glass, Kapton. Bending tests performed on flexible gratings demonstrate operation even at ~15mm bending radius, with about 5dB loss. The 1×16 cascaded multimode interference (MMI) based power splitter demonstrates uniformity of 0.96dB across all the 16 output channels, and an insertion loss of 0.56dB.The photonic crystal waveguides are designed to provide large time delay values within a short length. Photonic crystal tapers are implemented at the strip-photonic crystal waveguide interfaces to minimize loss and provide larger time delay values. A large group index of ~28.5 is calculated from the measurement data, thus indicating achievability of time delay larger than 58ps per millimeter length of the delay line within a tuning range of 20nm. The demonstrated building blocks present a viable path for obtaining scalable TTD modules on unconventional substrates.


Progenitor cell failure in the erythroid lineage is a particular problem in bone marrow failure. To provide insight into early erythopoietic development we used sensitive techniques to examine the effects of SCF, IL‐3 and MIP‐1α on two developmentally arrested progenitor cell lines, HEL and K562. Quantitative flowcytometric analysis showed that both expressed receptors (SCF > MIP‐1α >IL‐3). Qualitative analysis revealed HEL cells expressed more receptors than K562 cells. Clonogenic assays with sensitive haemoglobin detection showed that SCF and IL‐3 did not support HEL development and reduced haemoglobin production. MIP‐1α reduced partially developed HEL colonies and haemoglobin in developed colonies. SCF increased development, but not haemoglobin in K562 cells, with IL‐3 being more effective in both. MIP‐1α increased the proportion of well‐developed K562 colonies but not haemoglobin. This suggests SCF, IL‐3 and MIP‐1α all have a role to play in early erythroid cellular development, with differing actions depending on the stage of development.


Malaysia needs work forces that possess high commitment, productivity and progressiveness, competitive, and efficient in its mission to achieve the Vision 2020 targets. The aim of this study is to investigate the mediating effect of psychological empowerment on the relationship between work stress, pay satisfaction and organizational commitment among academic staff in public universities. This study is focus on academic staffs from public universities in Northern Malaysia. Academic staffs were chosen because they are dealing with a lot of tasks. A total number of 400 academics were chosen as respondents for the study but only 297 academics responded to
the questionnaire. Statistical Package software for Social Science (SPSS) Version 19.0 was used to analyze the collected data. Factor analysis, multiple regressions and correlation were applied to this study. The Pearson correlation analysis indicated that work stress is a negatively associated with organizational commitment and psychological empowerment whereas pay satisfaction, psychological empowerment and organizational commitment have positive relationship by each other. Furthermore, the multiple regression analysis revealed that psychological empowerment has a partially mediate on the connection with work stress, pay satisfaction and organizational commitment. It is suggested for future research to look at the way to influence and shaping the attitudes of academic staff by investigate some other important factors that able to improve their commitment towards organization


This paper studies the existence of symmetric positive solutions for a second order nonlinear semipositone boundary value problem with integral boundary conditions by applying the Krasnoselskii fixed point theorem. Emphasis is put on the fact that the nonlinear term f may take negative value. An example is presented to demonstrate the application of our main result.


An exploratory study was conducted to investigate the sensitivity of laminar flow controlled (LFC) boundary layers to external acoustical disturbances using a 2.4-m (8-ft) span, 6.1-m (20-ft) chord, and 30-deg swept wing section with laminar flow control through spanwise slots. The objectives were to identify Tollmien-Schlichting and other amplification frequencies, critical disturbance levels in the boundary layer, the influence of suction rate on these disturbances, and the transfer function between an external sound field and the corresponding disturbance induced in the boundary layer. The frequency sensitivity and turbulence amplification effects of sound waves on a laminar boundary layer were determined experimentally and were found to occur within the predicted Tollmien-Schlichting oscillation range. Other unidentified amplification phenomena were also detected. Relationships between suction rate, induced acoustical particle velocity, and turbulence intensity have been established, and further analytical work is in progress. The study was part of a NASA contract to evaluate LFC systems for commerical transport aircraft.


Preface.- 1 Translation Groups.- 2 Euclidean and Hyperbolic Geometry.- 3 Sphere Geometries of Mobius and Lie.- 4 Lorentz Transformations.- 5 delta-Projective Mappings, Isomorphism Theorems.- 6 Planes of Leibniz, Lines of Weierstrass, Varia.- A Notation and symbols.- B Bibliography.- Index.


During observations of the ultrastructure of juvenile human nucleus pulposus from scoliotic spines, banded structures have been found in the extracellular matrix. Similar structures have been encountered in the nucleus pulposus of normal rabbits. The banded structures show a periodicity which differs from that of native collagen. The present account describes their morphology in man and rabbit, and compares them with examples of other extracellular banded structures which have been described in mammalian tissues.


A hybrid photovoltaic-thermal (PV/T) greenhouse dryer of 150 kg capacity has been designed and constructed at Solar Equipments Development Unit (UDES) at Bou-Ismail, Algeria. The developed dryer has been used to dry the apricot waste when AC fan was in operation for forced mode convection. Experiments were conducted for drying of apricot waste in the month of June, 2016. Various hourly experimental data namely moisture evaporate, ambient air temperature and humidity, greenhouse air temperature and humidity, etc. were recorded to evaluate heat and mass transfer for the proposed system.


This paper takes a study on the main reason of extorting a confession by torture. There are the low diathesis and poor abilities to solve a case of deterctive personnel, little restriction for the right of inspect, not enough intendance, deterctive personnel misunderstanding entirely the legal spirit. For keeping within limits of it, we should improve the diathesis of deterctive personnel, the ability of cracking a criminal case, the comprete steps of intendance and so on.


This dissertation is a theoretical-methodological proposal for the construction of a Brazilian constitutionalism in pretugues (GONZALEZ, 1988) analyzing domestic labor from the category's fights for rights in Brazil (PINTO, 2015, BERNARDINO-COSTA, 2007). Our starting point is the participation of the domestic workers movement in the Brazilian Constituent Assembly of 1987/1988, marked by the silencing of their demands for fundamental rights for being considered "like one of the family" (RAMOS, 2018). Coined by Lelia Gonzalez (1988), pretugues, which designates marks of Africanization on the colonial languages of Nation States, is evidence of our denied ladinoamefricanity. Explanatory: there is no racial democracy. We are an African America, or rather, uma Amefrica Ladina. Considering the centrality of the exploitation of Black women's bodies in the formation of the modern world (ROBERTS, 1997), in terms of our constitutional theory and history, a few things need questioning. What is labor? What is family? What is democracy? And more importantly, in a slave democracy (MBEMBE, 2017), what is the face of the identity of the constitutional subject (ROSENFELD, 2003)? I propose the concept of Patriarchal Contract (MILLS, 1997, PATEMAN, 1988, CURIEL, 2013) to name race and gender limits in Brazilian constitutionalism, erected as a mirror of the Masters House, Casa Grande, in the image and likeness of patriarchal lords, or slave masters (SILVA, 2006). Domestic workers associations and unions in Brazil are comprehended as a constitutional movement (GOMES, 2018, QUEIROZ, 2017), which, although denied, co-builds the State and disputes the meanings of democracy, simultaneously as in and outsiders (COLLINS, 2019).


The affiliation and contact information for Tobias Hahn was published incorrectly. The correct information is a follows: Tobias Hahn Euromed Management School, Marseille, France. Email: firstname.lastname@example.com


A series of blends were prepared by different ratios of polylactic acid (PLA) and thermoplastic polyurethane (TPU) with a crosslinking agent of dicumyl peroxide (DCP). This study focused on the crystal structure, morphology, crystallization, and melting behaviors of PLA/TPU blends using a wide angle x-ray diffractometer (WAXD), a polarizing optical microscope (POM) and a differential scanning calorimeter (DSC). A Modified Avrami equation was applied to analyze non-isothermal crystallization kinetics of PLA/TPU blends. Results show that the nucleation of PLA was enhanced by the added TPU. The spherulitic growth rate, crystallization rate, and crystallinity of the PLA/TPU blends increased with an increase of TPU content. WAXD results show that all of the crystal reflections of PLA/TPU blends related to those of PLA.


The advertisement domain by the plane vision gradually to the newmedia digitization three-dimensional design transition, most receivesattacks is in two striations condition higher art design education theplane vision transmission to design these correlations specializedThe universities present stage needs to start to begin to raise theinternationalization digital art to design the talented person. Thisalso is in our universities art design education domain puzzled is at,how goes out the wonton, how will change the existing condition willbe has the challenge topic.


The integration of constrained optimization models as components in deep networks has led to promising advances in both these domains. A primary challenge in this setting is backpropagation through the optimization mapping, which typically lacks a closed form. A common approach is unrolling, which relies on automatic differentiation through the operations of an iterative solver. While flexi-ble and general, unrolling can encounter accuracy and efficiency issues in practice. These issues can be avoided by differentiating the optimization mapping analytically, but current frameworks impose rigid requirements on the optimization problem's form. This paper provides theoretical insights into the backpropagation of unrolled optimizers, which lead to a system for generating equivalent but effi-ciently solvable analytical models. Additionally, it proposes a unifying view of unrolling and analytical differentiation through constrained optimization mappings. Experiments over various structured prediction and decision-focused learning tasks illustrate the potential of the approach both computationally and in terms of enhanced expressiveness.


We measure the transmission spectrum of an optical cavity filled with two-level atoms. For small intensities, the coupling between atoms and a single mode of the cavity splits the spectrum into two normal modes: the vacuum Rabi peaks. We gradually decouple the system in two ways and study the evolution of the vacuum Rabi peaks. First we lower the atom-cavity coupling frequency through its intensity dependence, showing that the peaks shift, deform, exhibit frequency hysteresis, and eventually merge into a single peak that approaches the empty cavity resonance. Second we detune the atoms and the cavity mode and observe an avoided crossing. The normal modes of the coupled system transform into the two resonances of the uncoupled system. We map out the transition region and find good agreement with theoretical predictions. @S1050-2947 ~97!07910-9#


Introduction As more comparative material has become available over the years it has become possible to re-assess the observations and interpretations of some of the earlier writings on rock paintings in South Africa. This is helped by a realisation that one type of white paint has proved to be comparatively fugitive. It is quite common to find paintings of eland which have been reduced to rather indeterminate animals which appear to have a tail at each end. Anyone who has looked closely at a number of rock paintings will have realised that one of these 'tails' is a line painted to denote the top of the neck and, often, the front of the muzzle of the animal. A classic misinterpretation arising from this cause is the so-called lion attacking an eland on the back of the dustcover of Stow's Native Races of South Africa. It is, in fact, one of several eland which have 'lost their heads' but which complete the herd of eland on the front of the cover. The following examples are dealt with under the name of the author and publication to facilitate reference.


: Objective: To systematically evaluate the effectiveness of acupoint stimulation in improving pregnancy outcome of patients with repeated implantation failure. METHODS: From the establishment to December 2020, CNKI, VIP, Wanfang database, PubMed and Cochranelibrary were retrieved by computer, and the literatures of randomized controlled trials (RCTs) on acupoint stimulation therapy for repeated implantation failure were screened. The Cochrane bias risk assessment tool was used to assess the quality of the included studies and ReviewManager5.3 software was used to perform a meta-analysis of the results. RESULTS: A total of 9 literatures were included, involving 979 patients. The results of Meta-analysis showed that acupoint stimulation was superior to the western medicine treatment group in improving the clinical pregnancy rate and embryo implantation rate, and in improving the clinical pregnancy rate, embryo implantation rate and RI, and in improving the embryo implantation rate and RI, the placebo acupoint stimulation group was superior to the blank group. Conclusion: Acupoint stimulation can improve the pregnancy rate of RIF patients.


Since then his general health has been good except for occasional discomfort in the chest. Frequent blood examinations have been performed, and there has been slight chronic neutropenia (Table I). As there was a doubt that the neutropenia originally could have been caused by a sulphonamide drug administered on his first admission to hospital, a further course of sulphadlmidine was given (three grammes per day for seven days). There were no untoward effects, and only a slight lowering of the neutrophil count three or four weeks later was observed. Except for a short course of prednisone therapy (20 milligrammes per day for one week), he has had no other treatment.


The strapdown navigation system installed in targeting pod adopts low precision inertial components and the transfer alignment process is performed in low dynamic conditions. In view of the above phenomena, a method of 'specific force integral/angular velocity matching' is proposed, and the error model of the master and slave inertial navigation system is derived. The observability of the system states is analysed in condition of various instrument precisions and maneuvers. The simulation process is designed and the result shows that the misalignment of the method fits the performance index of the rapid transfer alignment.


SYNOPSIS A study of the incidence of peptic ulcer amongst railway workers in various parts of India has shown that ulcer is more common in wet and humid areas than in the dry and arid regions. This observation is also supported by the ulcer incidence reported in other studies from India, Africa, and the West. Saliva appears to have an important role in the prevention of ulcer, because of its rich content of blood group antigens. There may be unrecognized factors in the saliva which may be ulcerogenic and others which prevent ulcer. Parasympathetic overaction also appears to contribute to ulcer formation due to its effect on salivation, sexual activity, and stress and strain.


Combining with the features of the water conservancy projects,the paper indicates the investment control tasks and the controlling points for the supervision over daily investment at the construction phase,and points out the engineering cost control is the important measures in the supervision control and the supervision should exert the intelligent service,in order to meet the goal of the investment control.


This study sought to determine the role of government support structures and initiatives in the development of youth entrepreneurship in Khayelitsha, in the Western Cape Province of South Africa. The data was collected by way of questionnaires, whereby 132 participants were randomly drawn from the population of 200 youth entrepreneurs who were registered on the database of a local organisation for youth entrepreneurs in Khayelitsha. According the findings, there was no evidence to show that government support structures/initiatives were contributing in the development of youth entrepreneurship in this township. Recommendations to improve the current standard of youth entrepreneurship in the research setting were made. This paper provides an insight into the role of youth entrepreneurship support structures and initiatives in Khayelitsha, particularly to stakeholders such as government structures, which seek to advance youth entrepreneurship in Khayelitsha and others townships, in Western Cape. DOI: 10.5901/mjss.2014.v5n1p61


Tissue Engineering, the science and engineering of creating functional tissues and organs for transplantation, integrates a variety of scientific and engineering disciplines to produce physiologic "replacement parts" for the development of viable substitutes which restore, maintain or improve the function of human tissues. In recent Multi-Agency Tissue Engineering Science (MATES) Interagency Working Group [1], the field of tissue engineering has been broaden and redefined as "the use of physical, chemical, biological, and engineering processes to control and direct the aggregate behavior of cells". In the success of tissue engineering, three-dimensional (3D) scaffolds play important roles as extra-cellular matrices onto which cells can attach, grow, and form new tissues. Modeling, design and fabrication of tissue scaffolds to meet multiple biological and biophysical requirements is always a challenge in regenerative tissue engineering. This is particularly true when designing load bearing scaffolds for bone and cartilage tissue application. In general, this type of scaffolds usually have intricate architecture, porosity, pore size and shape, and interconnectivity in order to provide the needed structural integrity, strength, transport, and ideal micro-environment for cell and tissue ingrowth. In addition, thus designed scaffolds often can only be fabricated through advanced manufacturing techniques, such as solid freeform fabrication (SFF) to manufacture complex structural architectures.


A recent theory of auroras and magnetic storms attributes these phenomena to the action of a flash of ultraviolet light from the sun. The flash causes an unusual ionization in the Kennelly-Heaviside layer. Therefore, it is only daylight wireless circuits which are, or may be, disturbed at the commencement of the magnetic storm, the night circuits remaining normal until dawn when they may be disturbed; the disturbance in the daytime circuits may persist after night-fall. This very simple theory is found to be borne out in a detailed discussion of the data of the short-wave (15 to 40 meters) circuits of the United States Navy during the magnetic storms of May 28, July 7, October 18, and October 24, 1928.


The most likely fusion reaction to be practical is Deuterium and Helium-3 (D − He 3 ), which is highly desirable because both Helium-3 and Deuterium are stable and the reaction produces a 14 MeV proton instead of a neutron and the proton can be shielded by magnetic fields. The strongly dependency of the basically hot plasma parameters such as reactivity, reaction rate, and energy for the emitted protons, upon the total cross section, make the problems for choosing the desirable formula for the cross section, the main goal for our present work.


The large-scale wind farm composed of doubly fed induction generators (DFIGs) has become quite familiar over the last few years. These generators are driven by power converters which get small percentage of the power from the grid. An obvious drawback of the DFIG is that it is very sensitive to grid disturbances, especially to voltage dips. It becomes necessary to study on the auto-reclosing process of wind farm transmission line. Firstly, the significances of the auto-reclosing using on wind power transmission line are introduced. Secondly, the reclosing conditions for a successful reclosing and the special issues of auto-reclosing used in wind farm are pointed out. And then a wind power sending-out electromagnetic transient model has been built, according to the actual situation of wind power sending system. The performances of auto-reclosure under different delivery structures and network voltage level have been simulated. Finally, the simulation results are summarized, and an auto-reclosing strategy for large-scale wind farm transmission line is presented.


This paper presents a new simulated annealing algorithm to solve constrained multi‐global optimization problems. To compute all global solutions in a sequential manner, we combine the function stretching technique with the adaptive simulated annealing variant. Constraint‐handling is carried out through a nondifferentiable penalty function. To benchmark our penalty stretched simulated annealing algorithm we solve a set of well‐known problems. Our preliminary numerical results show that the algorithm is promising.


In this paper we construct nontrivial exterior domains $\Omega \subset \mathbb{R}^N$, for all $N\geq 2$, such that the problem $$\left\{ {ll} -\Delta u +u -u^p=0,\ u >0 & \mbox{in }\; \Omega, {1mm]
\ u= 0 & \mbox{on }\; \partial \Omega, [1mm]
\ \frac{\partial u}{\partial \nu} = \mbox{cte} & \mbox{on }\; \partial \Omega, \right.$$ admits a positive bounded solution. This result gives a negative answer to the Berestycki-Caffarelli-Nirenberg conjecture on overdetermined elliptic problems in dimension 2, the only dimension in which the conjecture was still open. For higher dimensions, different counterexamples have been found in the literature; however, our example is the first one in the form of an exterior domain.


New semi-passive negative impedance matching technology is put forward to enhance the sensitivity of piezoelectric acoustic sensor at low frequencies; what's more, the bandwidth of high sensitivity is very broad. Mason electro-mechanical equivalent model of piezoelectric acoustic sensor is established and analyzed. Based on impedance matching theory, the parameters of matching circuit are obtained. The sensitivity of this semi-passive piezoelectric sensor with the proper parameters can even exceed that of no matching circuit over 20dB in broad band of low frequency. It is validated by experimental measurements.


In Spain during the Old Regime, the remuneration for services within the Court, and for the servants of the Court, was a peculiar world that operated according to particular conventions and mechanisms of specific regulation, clearly differentiated in the complex flow of exchanges that occurred continuously between the monarch and his servers around the economy of grace. One form of payment for services, almost exclusively reserved for servers in the palace, was the granting of endowment grants to women to marry suitably. It didn't mind if they were servants of the house of the Queen, or whether they were daughters or nieces of those who held senior positions at court. So, through marriage, the monarchs provided tribunals of justice, counsellor employment and the most numerous, accountants in The Accounting Major Accounts.


PurposeThe purpose of the article is to examine the experiences of workers with intellectual disability (WWID) and subtle discriminatory practices that hold these workers back from thriving at the workplace.Design/methodology/approachThe research design employs the Shore et al. (2011) framework of inclusion supported by optimal distinctiveness theory (ODT) (Brewer, 1991). These theoretical frames are used to examine the potential for WWID to become members of a work group and experience the opportunity to develop their unique selves, negotiate and thrive through their work for purposeful career outcomes. A qualitative case study approach was adopted through interviews and focus groups with a total of 91 participants: 41 WWID, 5 human resource (HR) managers, 5 duty/department managers (DMs), 24 colleagues and 16 supervisors.FindingsThe authors found that enhancing inclusion is underpinned by the positive impact of human resource management (HRM) practices and line management support for WWID feelings of belongingness and uniqueness that enable them to thrive through their work activities. The authors demonstrate that WWID need manager support and positive social interactions to increase their learning and vitality for work to embrace opportunities for growth. However, when WWID do not have these conditions, there are fewer opportunities for them to thrive at the workplace.Practical implicationsThere is a need for formal HRM and management support and inclusive organisational interventions to mitigate discriminatory practices and better support WWID at work. There is an opportunity for HRM to design training and development around belongingness and uniqueness for this cohort of workers to maximise WWID opportunities to thrive through their work.Originality/valueThis study examines a cohort of WWID who are often forgotten and subtly discriminated against more so than other minority or vulnerable cohorts in the workplace, especially in terms of their development and reaching their full potential at work, which has an impact on their ability to thrive through their work. The paper makes an innovative contribution to the HRM literature through unpacking the processes through which Shore et al.'s (2011) conceptualisation of belongingness and uniqueness contributes to thriving for a marginalised and often overlooked cohort of workers.


Day by day as we are watching the elaborately mechanized systems of the nineteenth century disintegrate, or melt in the heat of passionate desire for change, as we feel civilization in a state of flux, with many still unmolten fragments of the old systems floating about, we art students must all of us be eagerly watching for forms expressive of the new epoch; for we are in the habit of reading the drama of world history through the things which man has made for his pleasure—his houses, furniture, pictures, temples. History to us is not a line extending backward into a distant past, but is rather a sphere into which all of the past is rolled, and we in the center of it have acquaintances in all epochs who tell us how the ball grew.


A number of arguments may suggest that solid continua could be investigated with spring cell substitutes instead of finite elements. The main arguments would be a simplified discrete representation, microstructural modelling, uniaxial material laws, the resolution of progressing damage and failure. However, the facts damp the high expectations. Only specific continua can be represented by spring cells.


Humanistic geography revisited travel research and humanistic geography qualitative traditions in travel research charting shared experiences travel as reach tourist discourse and tourist space sightseeing the encounter with the other culture integrating the experience of the other and home home, reach and the experience of the other as the experience of place.


In this paper, we investigate the performance of a wireless sensor network, in which multiple groups of source nodes communicate with their respective destination nodes with the help of a common relay network. A network code division multiplexing (NCDM) scheme is proposed to remove the inter-session interference among multiple transmission sessions at each destination. We focus on analyzing the soft processing algorithm of the NCDM scheme. Based on the analysis results, a new code design criteria for the construction of the generator matrix is proposed. Simulation results show that by following the proposed code design criteria, the bit error ratio (BER) performance gap between the scheme we studied and the serial session scheme can be managed effectively. In serial session scheme, source nodes in a number of groups communicate with their respective destinations in a time division manner.


ArticleType: ResearchPaper Panorama museums, the first examples of which are seen worldwide beginning from the 19th century, brought a new dimension to the concept of museology. Panoramas vary with the themes they choose, the countries they are located in, their structural features, and the social messages they want to convey. Panorama Konya Museum is an important museum that depicts the 13th century Konya and Hz Mevlana. In this research, Panorama Konya Museum is evaluated with the perspectives of tourist guides. First of all, the contributions of Panorama Konya Museum to tourism as a tourism destination, to the transfer of history and culture are discussed and information about the historical scenes in the visuals is given. In the study, in which a qualitative method was adopted, case samplingwas used, and the information obtained from the thirty tourist guides participating in the study was analyzed by a content analysis method. Tourist guides' views on the audience the museum adheres to, the information about the museum in the virtual environment, the value the museum adds to Konya, its value as investment, its role in the transfer of history and culture and its effects on visitors, the works of the museum management, the direction and information boards of the museum and the approach of the museum staff to tourists were all analyzed. The tendencies and reasons of the tourist groups to visit the museum, the positive and negative aspects of the museum, whether the guides would like to include the museum in their future tour programs and whether they received such requests from the visitors were investigated by interviewing the tourist guides.


A co-crystal of tetrakis(guanidinium) bis(eosinate) hexahydrate (I) was synthesized, and the molecular and crystal structures of (I) were determined by a single-crystal X-ray diffraction technique. The crystal system is triclinic with a space group of P1 and Z = 4. The unit-cell dimensions are a = 14.4774(8)A, b = 14.7735(8)A, c = 15.9316(1)A, with α = 64.739(1)°, β = 70.185(1)°, γ = 70.185(1)°, V = 2871.22(17)A3. The final R value is 0.0462 for 9198 observed reflections (I > 2σ(I)). The crystal packing is predominantly stabilized by hydrogen-bond interactions.


Public cloud providers seek to meet stringent performance requirements and low hardware cost. A key driver of performance and cost is main memory. Memory pooling promises to improve DRAM utilization and thereby reduce costs. However, pooling is challenging under cloud performance requirements. This paper proposes Pond, the first memory pooling system that both meets cloud performance goals and significantly reduces DRAM cost. Pond builds on the Compute Express Link (CXL) standard for load/store access to pool memory and two key insights. First, our analysis of cloud production traces shows that pooling across 8-16 sockets is enough to achieve most of the benefits. This enables a small-pool design with low access latency. Second, it is possible to create machine learning models that can accurately predict how much local and pool memory to allocate to a virtual machine (VM) to resemble same-NUMA-node memory performance. Our evaluation with 158 workloads shows that Pond reduces DRAM costs by 7% with performance within 1-5% of same-NUMA-node VM allocations.


Summary The Tellus airborne geophysical survey is a national survey of Ireland and therefore low-level flying occurs over numerous dwellings, farms and livestock. A Tellus Communications Viewer has been developed to manage survey operations allowing flight plans to be integrated with digitized polygons of relevant stakeholders who can then be contacted. The tool was created using open source software - Matererialize – a front-end responsive framework created by Google. While 'leaflet' software is used to allow interactions with maps. The tool also acts as a database management system logging all interactions with stakeholders. The system has been developed over a number of years and was fully operational for airborne surveys conducted in 2016.


adults were divided into three groups:young.old and aged.They were tested and trained through associative learning, figural free recall and additional association learning tests The purpose of this study was to investigate the effect of age, degrees of task difficulty and training on memory. The results indicated that: 1)the performances of the yeung group were significantly better than that of the two seniorgroups.There is no difference between the two senior groups. 2) The age difference of unrelated association is greater than that of related assecia tion.It is proportional to the degreesof task dif ficulty. 3) After training, the memory performa nces were improved in each age group. The age differences and the differences in degrees of task difficulty were increased by training. It showed that memory was affected by the interaction among age, degrees of task difficulty and train ing. The plasticity of cognitive function in the aged was also demonstrated.


The Senegaleses authorities arq planning an extension of high grass yield Graminacea crops. The magnitude of this extension implies knowledge of the eco-physiological bases of water use by these plants. Three plant types were taken as examples and a one year study was perjormed to determine the evolution of transpiration and the water potential in the vascularization during several characteristic days. The simultaneous and coupled study of these two important components satisjactorily reflects the physical state of resistance tq water circulation in the plant. When jlow-rates decrease, certain species respond by increasing water transit, which is rejlected by a higher production of dry natter in the consumable aerial portions. The examination of the jactors which may influence the characterislics processes of water economy in the plant Will enable us to both rationalize and improve the ejjiciency of irrigation methods, which are still too empirical in nature.


In this paper we present experimental results on the storage ring free electron laser operating in giant pulse mode with variable repetition rate. The experiments were conducted through a wide range of electron beam energies from 270 MeV to 600 MeV with the giant pulses generated using a gain modulator. Dependence of the peak and average power, and the other properties and parameters of giant pulses on the pulse repetition rate were studied. In particular, it was found that the average lasing power in the giant pulse mode can reach levels of 70-90% of that in the CW power mode. Applications of such mode of operation are discussed.


5 star Luxury Deluxe Cruise holiday of the Croatian Islands. Discover the Southern Dalmatian Islands in elegance and style aboard a state of the art Yacht specially chartered by Croatia Tours to offer an unforgettable holiday.


Abstract : The work accomplished indicates that it is possible to form helmet like shapes from manganese complex titanium alloy using explosive forming. At the present state of development, the slow and costly process of explosive forming appears impractical as a means of mass-production of helmets. As described in the technical portion of this report, several shots, with the time required for positioning, charging, and cleaning, are required to form the part without splitting or wrinkling.


Major changes have occurred in the structure of former centrally planned economies, including a sharp rise in the share of services in GDP, employment, and international transactions. However, large differences exist across transition economies with respect to services intensity and services policy reforms. The authors find that reforms in policies toward financial and infrastructure services, including telecommunications, power, and transport, are highly correlated with inward foreign direct investment. Controlling for regressors commonly used in the growth literature, they find that measures of services policy reform are statistically significant explanatory variables for the post-1990 economic performance of transition economies. These findings suggest services policies should be considered more generally in empirical analyses of economic growth


For help in preparation of this article, thanks to Mark Daly, Jean-Michel Pascal Gehenn, Will Grace, Dominic Lowden and Tony McGlue, Gatwick, England; Mark Egan and Norm Pedersen, Houston, Texas; Zied Ben Hamad, Lagos, Nigeria; Mahmoud Korba, Algiers, Algeria; and Andrew Smart, Kuwait. DSI (Dipole Shear Sonic Imager), Q-Borehole and VSI (Versatile Seismic Imager) are marks of Schlumberger. Omega2, Q-Land, Q-Marine, VIVID and Well-Driven Seismic are marks of WesternGeco. Advanced seismic acquisition and processing technology has come onshore.


Luxembourg has a well differentiated and highly complex national vocational training system. Like many other countries, Luxembourg has a binary secondary education system, consisting of the largely institutionally separate areas of classical general education (secondaire generale) and rather more practical vocational training (secondaire technique). In the school year 2012-2013, there were 12,958 pupils enrolled in general secondary education (33%) and 26,627 in technical secondary education (67%).
In the Luxembourg vocational education system at least four different qualifications can be distinguished; these are associated with very different possibilities for routes to subsequent education, such as access to higher education or training as a master craftsman. As compared to the other options, the regime technique provides the best opportunity to start university studies or, after one year of vocational training, to begin to train as a master craftsman. Of particular interest at the moment is the 2008 reform of vocational training, which is being implemented in stages between 2010 and 2015 and which is focusing more on skills and work processes, providing a more modular structure to the training and a more systematic combination of on-the-job- and school-based learning phases.
International influences on the Luxembourg vocational training system are visible at different levels: first, the Luxembourg system itself contains elements of the dual German system and the more school-orientated and predominantly state-organised French system. Secondly, international cooperation with neighbouring countries - especially cross-border dual training - is essential because of the country's small size and the small number of qualified vocational trainers. Thirdly, the predominantly German-speaking Luxembourg vocational training system faces major challenges because of the high proportion of immigrants. It is clear that the Luxembourg system contains a certain degree of 'mix-and-match' of different elements and educational principles, which contribute to the strong separation between different pathways in secondary education.
The vocational and practical training must not be a dead end for academically talented but linguistically disadvantaged pupils with an immigrant background, nor must vocational training be educationally unattractive for practically inclined and talented Luxembourgers for reasons of prestige. In order to formulate appropriate solutions in the context of these inequality-related problems, more international comparative research seems inevitable.
An additional area for in-depth analysis is assessing the impact of the reform of 2008 on vocational training. Currently, it is not clear what lies behind a number of potentially problematic developments within the system. For example, there needs to be discussion on whether the modularisation measures have led to an unintended fragmentation of vocational training, which would be contrary to the principles and uniformity of the various professions.

[http://www.men.public.lu/catalogue-publications/systeme-educatif/statistiques-analyses/bildungsbericht/2015/band-2.pdf Open access download of "Bildungsbericht Luxemburg 2015"]


Our world system is rapidly becoming more interconnected, and no natural, cultural, or technological resources are only ''local'' resources any longer. The ''globalization'' of resources and the problems caused by Farmer or folk crop varieties developed over many generations by increasing rates of resource use and degradation have inindigenous farmers are an important component of global crop ge- creased conflict over the meaning of, and rights to, renetic resources for use by both industrial and indigenous agricul- sources that have previously enjoyed somewhat sepature. Currently there is a debate between advocates of indigenous rate existences in indigenous and industrial worlds. farmers' rights in their folk varieties and the dominant world system, which vests intellectual property rights to crop genetic re- Crop genetic resources occupy a key position in this sources only in users of those resources for industrial agriculture. drama. Agricultural crops and their wild and weedy relWhile indigenous peoples at the individual and group levels do atives, like other genetic resources, embody very sohave a broad range of intellectual property rights in their folk va- phisticated information in their genetic structure as a rieties, they define and use them differently than does the industrial world. Therefore, industrial-world intellectual propery rights result of the history of selection pressures exerted by mechanisms are generally inappropriate for protecting the intel- the biophysical environment (the soils, climates, lectual property rights of indigenous farmers, but some could be plants, and animals). In addition, through human conused effectively. To meet indigenous farmers' need for protec- trol of crop evolution (domestication and varietal selection, new approaches are being developed that embed indigenous tion) and the crop-growing environment and direct gefarmers' rights in folk varieties in cultural, human, and environmental rights. More research on the cultural, social, and agro- netic manipulation by humans, these crops reflect the nomic roles of folk varieties, ongoing negotiation of the meaning values and social organization of many generations of of key concepts such as ''crop genetic resources,'' ''rights,'' and farmers and, more recently, those of modern plant ''indigenous,'' and an emphasis on a common goal of sustainabil- breeders and molecular biologists. ity will help to resolve the debate.


Objective To evaluate the effect of the single-session solution-focused self-coaching intervention on nurses' burnout.Method Sixty-four nurses were randomly divided into two groups.The nurses in the experimental group received single-session solution-focused self-coaching intervention,while the nurses in the control group received traditional problemfocused coaching intervention.Their level of professional burnout,perception of self control,disposition of optimism or pessimism and involvement of intervention were compared between the two groups.Results Although there was no significant difference in the professional burnout between the two groups(P 0.05),the perception of self control was significantly improved in the experimental group(P0.05).The perception of personal accomplishment in nurses with pessimism disposition was significantly improved(P0.05).Conclusions The single-session solution-focused self-coaching intervention can improve nurses' perception of self control and shows significant short-term efficacy in nurses with pessimism disposition.


This is an Element about some of the largest sites known in prehistoric Europe – sites so vast that they often remain undiscussed for lack of the theoretical or methodological tools required for their understanding. Here, the authors use a relational, comparative approach to identify not only what made megasites but also what made megasites so special and so large. They have selected a sample of megasites in each major period of prehistory – Neolithic, Copper, Bronze and Iron Ages – with a detailed examination of a single representative megasite for each period. The relational approach makes explicit comparisons between smaller, more 'normal' sites and the megasites using six criteria – scale, temporality, deposition / monumentality, formal open spaces, performance and congregational catchment. The authors argue that many of the largest European prehistoric megasites were congregational places.


Given the imminent threats of climate change, it is urgent to boost the use of clean energy, being wind energy a potential candidate. Nowadays, deployment of wind turbines has become extremely important and long-term estimation of the produced power entails a challenge to achieve good prediction accuracy for site assessment, economic feasibility analysis, farm dispatch, and system operation. We present a method for long-term wind power forecasting using wind turbine properties, statistics, and genetic programming. First, due to the high degree of intermittency of wind speed, we characterize it with Weibull probability distributions and consider wind speed data of time intervals corresponding to prediction horizons of 30, 25, 20, 15 and 10 days ahead. Second, we perform the prediction of a wind speed distribution with genetic programming using the parameters of the Weibull distribution and other relevant meteorological variables. Third, the estimation of wind power is obtained by integrating the forecasted wind velocity distribution into the wind turbine power curve. To demonstrate the feasibility of the proposed method, we present a case study for a location in Mexico with low wind speeds. Estimation results are promising when compared against real data, as shown by MAE and MAPE forecasting metrics.


The development of artificial intelligence-based systems, particularly the field of computer vision more specifically the detection of objects always involves a process of training and testing. The quality of the object detection greatly influenced the training process object detection. Viola-Jones method is often used in object detection process where this method requires a classifier file obtained from the training process. This research is used to determine the trend of the number of the training process on the quality of bottle caps object detection fanta, sprite, Frestea, coca-cola and soda. Tendency obtained can be linear or exponential graph. the result of the research detection a bottle cap, happened saturation amount of test data so that a larger number no longer affect the quality of detection the bottle caps and the relationship between the number of files of positive file and negative file affect the accuracy in detecting an object .


Using ANSYS software,the vibrating frequencies of simply supported skewed slab were calculated,fundamental frequency parameters and the first 5-order frequencies with different skew angles were analyzed.The skewed slab was meshed by thin plate element,the vehicle was modeled as moving mass,the vehicle-bridge coupling vibrating system was introduced to establish the analytical method.The influences of skew angle,vehicle velocity,and vehicle running manners on the impacting factors of deflection and moment were investigated.The changing rules of impact factors with different skew angles,vehicle velocities,and vehicle running manners were summarized.Some conclusions are obtained that the fundamental frequency augments with skew angle augmenting,there are no monotonous rules between impacting factor and vehicle velocity,the impacting factors of deflection and moment are not identical for different cross sections.