Induced pluripotent stem (iPS) cells hold the potential to dramatically improve cell-based therapies and in vitro drug screening applications in the near future. Yet, for iPS cells to have a clinical impact, these cells must be generated in sufficient quantity and quality that currently exceeds today's capabilities. To meet these cell needs, a comprehensive understanding of how environmental conditions affect iPS cell metabolism and pluripotency is essential. Rapidly proliferating cells, including cancer and iPS cells, catabolize glucose and secrete lactate at elevated rates, even in the presence of sufficient oxygen, a process referred to as the Warburg effect (Vander Heiden, Cantley, Thompson 2009; Varum et al. 2011; WARBURG 1956). In cancer cell metabolism, lactate accumulation is associated with cancer stem cell-like gene expression, drug-resistance, metastasis, and poor prognosis in breast cancer patients (Martinez-Outschoorn et al. 2011). In addition, lactate has previously been shown to stabilize hypoxia inducible factors and induce a hypoxic response for cells cultured in normoxic environments (Pérez-Escuredo et al. 2016). However, there remains an incomplete understanding of the metabolic role of lactate for iPS cells and its effects on pluripotency. This study examined the impact of extracellular lactate on cellular metabolism and pluripotency of iPS K3 cells grown with sufficient glucose. Extracellular glucose, lactate, and amino acid concentrations were monitored throughout the experiment to determine the extracellular consumption or production fluxes. In addition, [1,2-13C] glucose, [U-13C] glutamine, and [U-13C] lactate isotope tracers were used in parallel labeling experiments to determine the intracellular metabolic contribution of each carbon source to iPS cell metabolism. High extracellular lactate resulted in altered cell metabolism, including a decrease in lactate production and glucose consumption. This was coupled with a decrease in glucose contribution to the TCA cycle. Also, lactate was catabolized to pyruvate, alanine, and TCA intermediate metabolites in the high-lactate condition. Furthermore, high extracellular lactate did not affect iPS cell pluripotency. These results suggest that lactate partially serves as a metabolic substrate for iPS even as it continues to accumulate in the extracellular media. The implications of these findings towards understanding iPS cell metabolism and improving future cell culture conditions will be discussed.


The Regional elections in 2018 was followed by 171 regions which was spread across 34 provinces throughout Indonesia. The 2018 simultaneous regional elections aimed to elect regional leaders, namely the Governor and the Mayor / Regent. The City of Bima is a part of the simultaneous local election to elect the Mayor and Mayor of Bima. The election contest was followed by the couple of Muhammad Lutfi and Feri Sofiyan from the Golkar and PAN parties. This couple was known by their supporters as Lutfer (Lutfi Feri). The couple's victory was inseparable from the strategy which was used to win the position of Mayor and Deputy Mayor of Bima in 2018. Therefore, this paper discussed the strategies which were used by the Lutfer pair in winning political competition in the City of Bima. The winning strategies included the strategies that carried out by the candidate pair, the coalition / bearer party, the success team and volunteers / sympathizers. The method used in qualitative descriptive this paper was based on the results of research by the researchers in the City of Bima. The purpose of this paper was to find out the strategies which were used by the Lutfer pair, coalition / bearer parties, success teams, and volunteers / sympathizers in winning the 2018 regional election in Bima. The results of the study showed that the strategies which were adopted by the candidate pairs, coalition / bearer parties, teams success, volunteers/sympathizers included the network strategies, imaging strategies and political campaign strategies.


As production workers in late-nineteenth-century American heavy industry moved towards regular use of concerted action, including the strike, to gain their demands, employers generally adopted rigid policies of opposition. That it was a frightening period for manufacturers, with prices for their goods steadily falling and widespread business failure, has been emphasized by Edward C. Kirkland and others. But lack of scholarship in business archives has improverished labor-management history on this point. Professors Skaggs and Ehrlich offer one case history, based on a study of the "inner truth" of such a conflict in the 1880s. It confirms the suspicion that it was not practical economic imperatives but a long-run policy to maintain the principles of paternalism that often accounted for the intransigence of management.


ABSTRACT The soil water retention characteristics curve (SWRC) has been reported to be quite useful for estimation of unsaturated soil properties. However, the uniqueness of SWRC is questionable due to hysteresis associated with the drying- and wetting-path SWRCs and this poses great challenge in utilising the SWRC for reliable estimation of unsaturated soil properties. Although hysteresis associated with SWRCs has been extensively studied for coarse-grained soils, due to limited studies on wetting-path SWRC for fine-grained soils, the hysteresis for fine-grained soils is not well understood. The present work attempts to address this gap, by studying the drying- and wetting-path SWRCs for eight different fine-grained soils by employing Dew point Potentiameter (WP4C®), Environmental Chamber and Controlled Water Sprinkling method. The study employs the concept of 'Suction Hysteresis', ψh, for quantification of hysteresis. Further, the influence of various soil-specific properties on the variation of ψh-water content relationship (viz., slope of variation of suction hysteresis, Sψh) has also been studied and demonstrated. The findings of the study are quite encouraging and it has been realised that extensive studies on soils of different characteristics would be quite useful in quantifying the variation of SWRC during drying and wetting cycles.


The manufacturing and non-destructive testing of the superconducting poloidal coil PF1 is one of the tasks of NIIEFA, the member of the international ITER project. Radiographic films were traditionally used for the purposes of radiation non-destructive testing. The technology of computed radiography was used to substitute films. It improved the quality of testing and increased productivity. Comparisons of testing results were carried out using films and imaging plates. The "Test Measurement for Qualification of Computed Radiography method for HI PF1 Weld Seams testing" was developed. It allowed to do testing using imaging plates without installing a duplex wire indicator. Compliance with the standards requirements for unsharpness is confirmed using certified specimens.


SUMMARY THE RELATIONSHIP BETWEEN BASAL PLASMA s-ENDORPHIN LEVELS AND THE SEVERITY OF MAJOR DEPRESSIVE EPISODE Objective: Although several studies performed in depressed patients have shown a deficiency in endorphin activity, plasma studies of s-Endorphin (s-EP) in depressive disorders have produced conflicting results so far. The aim of the present study was to test the hypothesis that possible changes in basal s-EP levels are related to severity of major depressive episode. Methods: 36 patients (17 females, 19 males) who were diagnosed to have major depressive episode according to the DSMIV criteria (mean age±SD:48.6±13.2) and admitted to the psychiatric ward of our university teaching hospital and 13 healthy subjects (mean age 38.70±10) participated in the study. They had HAM-D and MADRS scores above 15 and 8, respectively, at the time of evaluation. Morning plasma s-EP levels were determined with standart RIA kits. Results: Basal plasma values of sEP were significantly higher in the patients than in the control subjects (t=2.66 p<0.05). Furthermore, there was a significant correlation between basal plasma s-EP levels and HAM-D and MADRS scores (r=0.59 p<0.05 and r=0.57 p<0.05, respectively). Conclusion: Our data support the hypotheses that: 1) Significantly higher plasma s-EP levels in patients with major depressive episode compared to controls reflect a central limbic disturbance. 2) Significantly correlated plasma s-EP levels with severity of depressive symptoms also reflect magnitude of central limbic disturbance during major depressive episode.


With Mianyang topographic map of 1∶10000 in 1970,evolution of urban land use map of Mianyang in 1931-1991 and general planning map of urban land use of Mianyang in 1997-2010,this paper carries out analysis in temporal and spatial sequence to the dynamic change of urban pattern by GIS approach.Through both qualitative and quantitative analysis,it comes to a conclusion that the urban pattern of Mianyang is developing with accelerated speed and the axe-oriented expansion is greater than extroversion expansion.Its distribution is coming into being a radial,multi-centre along the river terrace.It offers a decision basis for making and perfecting the urban planning rationally,realizing sustainable development of the social economy and ecological environment in the city.


Objective: To develop the method of typing bacteria by pulsed field gel electrophoresis,and study the homology of isolates from the various foods in Jiangsu province.Methods: 21 strains of salmonella were collected from various foods of different cities in Jiangsu province and typed with pulsed field gel electrophoresis,then analyzed using BioNumerics software.Results: There were many types of salmonella in 21 strains of isolates.The homology of salmonella isolated form raw pork of Yangzhou city reached 88%.No identical molecular type by pulsed field gel electrophoresis was found in 21 isolates.Conclusion: Pusled field gel electrophoresis method with the high resolution,stability and repeatability is rapid and effective in tracking the bacteria source in food safety incident.


A multi degree of freedom skeletal muscle system stimulated via optical control is presented. These millimeter-scale, optically excitable 3D skeletal muscle bio-actuators are created by culturing genetically modified precursory muscle cells that are activated with light: optogenetics. These muscle bio-actuators are networked together to create a distributed muscle system. Muscle systems can manipulate loads having no fixed joint. These types of loads include shoulders, the mouth, and the jaw.Copyright © 2013 by ASME


Section 1: Introduction 1. Introduction Section 2: Immigrants 2. Accepting Immigrants 3. Dealing with the Unwanted 4. Impact of Immigrants Section 3: Refugees 5. Modern Efforts to Protect Refugees 6. Problems of Protection Section 4: Citizenship 7. Rise of Nationalism and Citizenship 8. Naturalization Section 5: Conclusion 9. Beyond Conventional Approaches to Migration and Citizenship


roquinolone-resistant strains in the field. Antimicrob Agents Chemother. 1999;43:2131-7. 5. Renuka K, Kapil A, Kabra SK, Win N, Das BK, Prasad VV, et al. Reduced susceptibility to ciproflixacin and gyrA gene mutation in North Indian strains of Salmonella enterica serotype Typhi and serotype Paratyphi A. Microb Drug Resist. 2004;10:146-53. 6. Hakanen A, Kotilainen P, Jalava J, Siitonen A, Huovinen P. Detection of decreased fluoroquinolone susceptibility in salmonellas and validation of nalidixic acid screening test. J Clin Microbiol. 1999;37:3572-7. 7. Booker BM, Smith PF, Forrest A, Bullock J, Kelchlin P, Bhavnani SM, et al. Application of an in vitro infection model and simulation for reevaluation of fluoroquinolone breakpoints for Salmonella enterica serotype Typhi. Antimicrob Agents Chemother. 2005; 49:1775-81. 8. Kadhiravan T, Win N, Kapil A, Kabra SK, Renuka K, Misra A. Clinical outcomes in typhoid fever: adverse impact of infection with nalidixic acid-resistant Salmonella typhi. BMC Infect Dis. 2005;5:37. 9. Crump JA, Barret TJ, Nelson JT, Angulo FJ. Reevaluating fluoroquinolone breakpoints for Salmonella enterica serotype Typhi and for non-Typhi salmonellae. Clin Infect Dis. 2003; 37:75-81. 10. Butt T. Ahmad RN. Mahmood A, Zaidi S. Ciprofloxacin treatment failure in typhoid fever case, Pakistan. Emerg Infect Dis. 2003; 9:1621-2.


The main parallel imaging techniques have been implemented under MATLAB (SENSE, PILS and SPACE-RIP for image domain, and SMASH and GRAPPA for k-space domain), evaluating its characteristics about image quality and signal to noise ratio. PILS and SMASH, with an specific coil configuration, provided the best results. SENSE and SPACE-RIP were more versatile with any coil configuration. All methods arrived to its acceleration factor theoretical limit (R=4 for 4 coils) with images without noise. Only those methods that depend on a matrix reconstruction inversion (SENSE and SPACE-RIP) did not arrive to the theoretical limit for noisy images due to its instability problems. PILS provided the best results although SENSE and SPACE-RIP can be applied under more general conditions. For the k-space domain methods, SMASH gave the best results under an specific coil array configuration.


Rate coefficients and product branching ratios for the ion-molecule reactions of the hydroxyl cation, ionized water, and their deuterated analogues with ethylene have been determined using a selected ion flow tube (SIFT) at room temperature and in 0.5 Torr of helium buffer gas. In all cases, reactions proceed at or near the collision rate. The major product is always charge transfer: 79% for L2Oand 66% for LO+ and does not depend on the isotopic form of hydrogen present (L ) H or D). For the L2O reactions, the remaining 21% of products are from proton or deuteron transfer, with no evidence of an isotope effect on this step even in the HOD•+ reaction. The greater exothermicity of the initial charge transfer in the LO+ reaction is revealed by the observation of additional product channels, forming the vinyl cation and protonated carbon monoxide. Multistep mechanisms that proceed through rate-determining charge-transfer, followed by a product-determining step, are postulated to explain these observations.


We measured ABA content and sensitivity in bulblels of Lilium speciosum Thunb, regenerating from scale explants in vitro at temperatures (15, 20 or 25°C) that allowed the development of various levels of dormancy (very low, intermediate or high, respectively). The one-step purification and the accuracy of the immunoassay were confirmed by HPLC and by liquid chromatography/mass spectrometry. ABA content was not correlated with dormancy development. Sensitivity to ABA was determined as the difference in sprouting performance of excised bulblets on medium with and without ABA. In bulblets regenerating at 20 or 25°C. ABA sensitivity was high during the period of dormancy establishment and decreased thereafter. Dormant hulblets were almost completely insensitive to ABA. The changes in sensitivity to ABA were confirmed by measuring the level of ABA in bulblets at the time of sprouting. This level was, as expected, highest in bulhlels with low ABA-sensitivity. Briefly cold-treated bulblets, in which dormancy may he re-established by culture at 20°C, again became sensitive to ABA. ABA sensitivity decreased with increasing temperature bulblets that regenerated at I5°C and hardly developed any dormancy, were very sensitive to ABA. It was concluded that in addition to ABA sensitivity another, still unknown, factor played a key role in dormancy development.


Dr. David Ludwig writes that if we don't take steps to reverse the course of the obesity epidemic, the children of each successive generation seem destined to be fatter and sicker than their parents. Ludwig discusses four overlapping phases of the epidemic. Dr. David Ludwig discusses the childhood obesity epidemic, its long-term consequences, and nutritional and political approaches to combatting it. Dr. Ludwig is director of the Optimal Weight for Life Program in the Division of Endocrinology, Children's Hospital Boston, and an associate professor of pediatrics at Harvard Medical School.


In this Study, the surface energy was investigated for six penetration grade70/100 bitumen binders. Wilhelmy Plate and the Sessile Drop were used todetermine the contact angles.The purpose of this study was to compare the Wilhelmy Plate method with theSessile Drop method, and to compare the significance of Owens-Wendt modelwith the significance of Acid Base model by correlating surface energycomponents. Better R2 –values were found for surface energy components byusing the Owens-Wendt model than by using the Acid Base model. It wasconcluded here that Owens-Wendt model is a better model for determiningsurface energy components of bituminous binders than the Acid Base modelsince bituminous binders have low energy surfaces.For both instruments: When using Diiodomethane as a probe liquid the biggestvariations among the binders were observed. When using water as a probeliquid the least variations among the binders were observed.The advancing contact angles for water determined for these six bitumenbinders using the Wilhelmy plate method do not exceed the 90 degree bymuch, suggesting that bitumen is not extremely hydrophobic.The Sessile Drop method offers a faster and more convenient way to measurethe surface energy components of bitumen binders than the Wilhelmy Platemethod.


Evaluation of two techniques to characterize fatigue delamination using the double cantilever beam (DCB) specimen are presented. The two techniques were the delamination growth onset (G-N) method and the delamination growth the arrest (da/dN-G) method. Two glass/epoxy systems, S2/SP250 and S2/CE9000, were tested at R=0.1 and R=0.5. The values of strain energy release rate threshold, ΔG Ith for no onset of delamination growth until one million cycles were compared with the values of ΔG I at delamination arrest. The values of ΔG I at delamination arrest were consistently higher than the values of ΔG Ith . The ΔG I results were normalized by the value of mode I Interlaminar fracture toughness at the corresponding Δa and gave values at delamination arrest closer to the ΔG Ith /G Ic values obtained from the G-N technique. However, this normalization does not represent a generic materials characterization technique and does not allow for delamination onset predictions at loads above the threshold.


The federal elections of 2013 generated an unusual situation for the German party system: a very strong extra-parliamentary opposition. The liberal FDP and the newly emerging AfD, with 4.8 per cent and 4.7 per cent, respectively, of the votes, ended up as the extra-parliamentary opposition, although both parties were ultimately successful in entering the German parliament in 2017. What strategies did these parties apply? How did they manage to get into parliament in 2017? The German case presents a unique situation, with the FDP, an experienced mainstream government party, and the AfD, a challenger party, belonging to the extra-parliamentary opposition. Clarifying first the concept and function of an extra-parliamentary opposition, the article describes, using manifesto data, the transformation of the German political space and the growing salience of the new cultural divide. The AfD contributed to establishing this divide by applying populist rhetoric. By contrast, the FDP succeeded by using a party-elite-led re-branding and re-framing of economic issues in the times of digitalisation.


INTRODUCTION With restructuring ahead, utilities may soon find themselves doing something they have not had to do on a broad scale in over 70 years - competing for customers. Power marketers are set to flex their muscles in the industry. They view their core competency as acquiring customers, regardless of the industry - telecommunications, natural gas, or electricity. On the other hand, utilities have had little reason to develop customer acquisition skills except to secure large power users. Consumer-owned utilities (COUs) may be particularly vulnerable in a restructured industry, especially to price competition. Two surveys by Mississippi cooperatives revealed customer propensity to switch on the basis of price. One survey in late 1996 found that 31% of respondents would switch to another electric utility for 10% lower rates. Fifty-six percent would switch for 20% lower rates. A mid-1997 survey by another cooperative showed 27% would switch for a 5% rate reduction, 42% for a 10% rate reduction, and 51% for a 15% rate reduction. With such propensity to switch, can COUs compete on price alone or are other factors available to retain the consumer base? Does relationship marketing hold the answer for COUs sustaining an advantage in a restructured, competitive environment? PARADIGM SHIFT IN MARKETING Relationship marketing is one of the newest schools of marketing thought. Unlike the customer-acquisition focus on traditional marketing, relationship marketing focuses on retaining existing customers (Berry 1995). It concentrates on the long-term, ongoing relational exchange so vital to service firms today (Dwyer, Schurr, and Oh 1987) and represents a genuine paradigm shift in marketing theory (Morgan and Hunt 1994). The recent work of the Electric Cooperatives Brand Identity Steering Committee of the National Rural Electric Cooperative Association (NRECA) underscores the importance of relationship marketing as a tool for long-term competitive advantage. The 42-member committee introduced Touchstone Energy to symbolize the various elements that "represent the relationship between COUs and their consumer-members and the communities they serve," said Glenn English, NRECA chief executive officer. "The brand identity embodied in Touchstone Energy is an important development in helping electric co-ops retain their current customer base and prepare for increasing competition in the industry" (Miller 1997). As shown in Figure 1, trust and commitment are key elements for retaining customers. Trust is particularly critical for service related firms since the product - a service - is intangible and difficult to evaluate before or after a purchase. Trust exists when one party has confidence in the reliability and integrity of the exchange partner. Commitment refers to the belief by both parties that the relationship is worth working on to ensure it endures indefinitely. However, commitment cannot exist without trust first being established (Morgan and Hunt 1994). But how can COUs build trust and commitment? Research indicates that trust is built through customer communications and low opportunistic behavior. In other words, communications should be meaningful and provide timely information to customers (Anderson and Narus 1991). Furthermore, trust is lowered when customers perceive that a firm acts opportunistically. Commitment results when customers perceive the cost of terminating the relationship are high or when the benefits received from the relationship are high. And finally, customers who share values with the firm have higher levels of trust and commitment (Morgan and Hunt 1994). How does trust and commitment lead to customer retention? The higher a customer's level of commitment to a COU, the lower their propensity to leave. Furthermore, higher levels of customer trust in a COU result in higher customer perceptions that problems that may arise will be resolved fairly and in lower decisionmaking uncertainty (Morgan and Hunt 1994). …


The aim of this study was to assess the association of hypocalcemia at calving with health and performance of Holstein cows and their calves. Data were collected January 1st 2017 to December 31st 2020. A total of 431 lactating Holstein Friesian cows (118 primiparous and 313 multiparous) from a research of hypocalcemia was 2 groups (hypo and non-hypo). The overall prevalence of hypocalcemia was 3.4% for first-lactation cows and 18% for multiparous cows. Lactating dairy cows with hypocalcemia had greater proportion of cows with Retained Fetal Membranes (RFM) metritis and culling within 60 days in milk (DIM), compared with non-hypocalcemia respectively. For the first 2 official milk tests milk yield and components (% fat, % protein on SCC) did not differ between hypo and non-hypo cows. The days in milk at first service, mastitis, dystocia and pregnancy at first service were not different between hypo and non-hypo groups. The proportion of stillbirth, survival at 60 days of age in calves did not differ between calves born from hypo or non-hypo cows. Calves born from Hypo cows had greater incidence of diarrhea (38.3%) than calves born (22.3%) from non-hypo cows. The results of this study show that hypocalcemia in calving has significant health implications for both dams and their calves.


The Information Age Strategy Strategic Ideas Strategic Configurations of Power Breeder Strategy IT Organizational Design for the Information Age Anatomy of an IT Guru Epilogue: The Way of the IT Warrior Appendices Index.


Objective
To understand the status of colleague support and colleague solidarity of nurses, and explore the relationship between colleague support and colleague solidarity.

Methods
A total of 231 nurses from Zhengzhou City were chosen using convenience sampling method to complete the questionnaire survey about colleague support and colleague solidarity.

Results
The nurses' colleague support scored (76.34±2.75) totally and colleague solidarity scored (64.63±4.25) totally. In dimensions of nurses' perception of colleague support, head nurse support, support result, cooperation, sympathy establishment, awareness increasing were positively correlated with emotional unity dimension of colleague solidarity (r=0.32, 0.26, 0.27, 0.30, 0.28, all P<0.05); head nurse support, support result, cooperation, awareness increasing, goal setting, action projects were positively correlated with academic unity dimension of colleague solidarity (r=0.30, 0.28, 0.25, 0.29, 0.27, 0.26, all P <0.05); head nurse support, support result, cooperation, awareness increasing, action projects and process management were negatively correlated with negative views of colleague solidarity (r=-0.31, -0.27, -0.30, -0.23, -0.24, -0.27, all P <0.05).

Conclusions
Improving the nurse colleague-peer support can improve degree of colleague solidarity.

Key words:
Nurses; Colleague support; Colleague solidarity


Making the weak assumption that the left-hand side of this equation is downward sloping, there will be a unique Y that solves this equation, which depends only on the sum of the marginal costs, not on their distribution across the firms. The observation that output and price in a Cournot industry is independent of the distribution of marginal costs has undoubtably been noted and used several times in the literature. See for example, Dixit and Stern (1982) Katz (1984) Loury (1983) or Bergstrom and Varian (n.d.). Note that the same independence result holds in any conjectural variations model, as long as all firms have the same conjectural variation and we consider only interior equilibria. The latter condition becomes increasingly important as the market equilibrium approaches a competitive structure, since in that case only the low cost producer will produce a positive amount. Here we consider an application of this result to a taxation problem. Suppose that each of the n firms in the industry faces a quantity tax t,. Then this tax is just the same as a marginal cost, so we can apply the above result to show that the equilibrium output and price is independent of the distribution of taxes across the firms. Furthermore, if we make a tax change (At,) that preserves the sum of the taxes, we must satisfy the first-order condition


This study aimed to produce quail egg powder by freeze-drying and to evaluate its stability in different types of flexible packages (low-density polyethylene, polypropylene and pigmented polypropylene) in high relative humidity (approximately 81%) at 25 °C during 59 days. The packages were evaluated for water vapor permeability and freeze-dried egg was characterized as to bulk density and hygroscopicity (initial time), and moisture, water activity, pH and color (until the end of storage). GAB, BET and Peleg sorption isotherm models were adjusted to the experimental data to predict monolayer moisture content in the powdered eggs. The freeze-dried quail eggs presented a little oscillation in color coordinates, reduction in pH, and increase in moisture content and water activity during storage for all packages used. No evaluated packaging was sufficiently effective as a moisture barrier. GAB and BET models fitted better to the experimental data for the freeze-dried quail egg, and the estimated monolayer moisture values were 0.0333 and 0.0227 g H2O/g solids, respectively. The powdered quail egg has industrial potential, however, it is susceptible to significant changes throughout storage when exposed to high relative humidity and conditioned in the tested packages. Commercially, as this product can be sold in regions with different temperatures and relative humidity, it is essential to consider the use of preservatives or anti-wetting agents.


Signal estimation problems with smoothness and sparsity priors can be naturally modeled as quadratic optimization with $\ell_0$-"norm" constraints. Since such problems are non-convex and hard-to-solve, the standard approach is, instead, to tackle their convex surrogates based on $\ell_1$-norm relaxations. In this paper, we propose new iterative conic quadratic relaxations that exploit not only the $\ell_0$-"norm" terms, but also the fitness and smoothness functions. The iterative convexification approach substantially closes the gap between the $\ell_0$-"norm" and its $\ell_1$ surrogate. Experiments using an off-the-shelf conic quadratic solver on synthetic as well as real datasets indicate that the proposed iterative convex relaxations lead to significantly better estimators than $\ell_1$-norm while preserving the computational efficiency. In addition, the parameters of the model and the resulting estimators are easily interpretable.


First, the factors that influence the blocking voltage BVAK of power static induction thyristor (power SITH) are discussed and some new anode structures are proposed to improve it. From the experimental results, a new kind of anode is structured, which is based on p+np- anode structure and striped p+ region and this new anode structure can reduce the anode injection and improve the blocking voltage. Meanwhile, the undoping transparent part of the anode forms a current drain. It is helpful for the charge extraction from the base during the device turn-off and cuts the tail current as well as turn-off losses.


The future significance of macroeconomic regulation policies is stressed in the article. The far-sightedness of present policies is necessary in the realization of development goals. At the same time, the consistency between macroeconomic regulation and well-maintained market economic system is also proposed, with the further analyses of the investment into the human resources in backward areas and the emphases on environmental protection, the strengthening of the regulation of population and the realization of sustainable development.


This paper considers the hybrid flow shop scheduling problem for the objective of minimizing the number of tardy jobs. In hybrid flow shops, each job is processed through multiple production stages in series, each of which has multiple identical parallel machines. The problem is to determine the allocation of jobs to the parallel machines at each stage as well as the sequence of the jobs assigned to each machine. Due to the complexity of the problem, we suggest search heuristics, tabu search and simulated annealing algorithms with a new method to generate neighborhood solutions. In particular, to evaluate and select neighborhood solutions, three surrogate objectives are additionally suggested because not much difference in the number of tardy jobs can be found among the neighborhoods. To test the performances of the surrogate objective based search heuristics, computational experiments were performed on a number of test instances and the results show that the surrogate objective based search heuristics were better than the original ones. Also, they gave the optimal solutions for most small-size test instances.


And the group management apparatus and a substrate processing apparatus for processing a substrate, connected to the substrate processing apparatus, a substrate processing system including, the group management apparatus, process the monitor data indicating the progress or status of the apparatus of the substrate processing substrate communication means for receiving from the apparatus; A database unit for storing in association enables the read monitor data received by the communication means to produce information data; It reads the display data and the production information data from the database unit, and generates the representative value data based on the monitor data and monitor data, production information data and a representative file archive section to create a file for which a read can be stored including the value data .; And accepts an input predetermined search condition to search for a file, and the data retrieving unit to display the data contained in the files which match the search condition on the display means; and a.


The present study was performed to investigate whether Plasmodiophora brassicae can be disseminated by livestock manure. A quantitative PCR (qPCR) assay was developed and used to detect and quantify P. brassicae in manure samples from naturally and artificially infested chickens and pigs. In naturally infested manure, quantifiable levels of infestation were observed in 7 out of the 28 samples, ranging from 103 to 107 resting spores per g of manure. The vast majority of the resting spores (76–91%) were viable, as determined by a dual fluorescence viability assay. Clubroot symptoms developed on plants inoculated with P. brassicae resting spores isolated from all seven qPCR-positive samples. Artificially infested manure samples were produced by feeding chickens and pigs on P. brassicae-contaminated feed. The levels of infestation were 103 resting spores per g of manure for both chicken and pig manure sampled 24 and 48 h after feeding, respectively. Spore viability was >80% for both samples, and the disease severity indices were both >40 as indicated by bioassay. This showed that resting spores can survive the digestive tracts of chickens and pigs, and retain strong pathogenicity. The findings indicate that manure dissemination is possible for P. brassicae. Farmers should avoid feeding livestock on P. brassicae-contaminated feed or applying infested manure as fertilizer on land intended for crucifer crops.


A siminar on the status of women in Latin America organized by the Inter-American Bar Association and the Law and Population Program and held in Cartagena, Colombia, developed 10 recommendations to improve the status of women in these countries. General areas covered included education, awareness of women's rights, establishment of national commissions to monitor legal status of women, an end to discrimination in marrage and divorce, equal legal status for all children, equalization of property and inheritance rights, contraception, sex education, and equalization of grounds for dissolution of marriage. The specific recommendations for family planning were: 1) remove legal barriers to importations of contraceptives; 2) use the concept of responsible parenthood as an effective means to promote family planning services; 3) provide family planning information, education, and services to minors who have reached the age of puberty and give legal protection to those providing such services; 4) provide population and sex education in school and nonschool settings; and 5) encourage mass media to regularly present family planning issues.


Wheat products are very important in human diet pattern, so that, they guarantee 40-45 percent of their calorie and about 50 percent of their protein requirements. In order to evaluate gluten content and some nutrients in different varieties and different wheat types including spring and winter wheat, an experiment was conducted in agronomy laboratory of Agriculture College of Mohaghegh Ardabili University in 2012 based on completely randomized design. 15 wheat varieties were selected and their bran percentage, dry gluten percentage in flour and bran and some elements concentration including sodium, potassium and calcium were measured. Results of variance analysis indicated that there was a significant difference among all of these varieties in all measured traits in probability of 1 percent. Means comparison indicated that protein content of spring wheat is often more than winter wheat and protein percentage in dry land wheat is more than irrigated one.


The Mobile Load Simulator (MLS10) is a new type of Accelerated Pavement Testing (APT) equipment recently purchased by Empa, Swiss Federal Laboratories for Materials Science and Technology. This paper summarizes the results of the first calibration tests of the MLS10 in Switzerland. The objective was to evaluate the performance of the machine for testing pavements constructed with local materials under local guidelines. The focus of the study was the structure of the A4 motorway near Zurich. Three pavements were constructed and trafficked with a total of 1.6 million 65 kN load passes over a period of approximately seven months. To access the structural response throughout the loading history, the pavements were instrumented with different sensors. Transverse profiles of the surface were periodically taken. FallingWeight Deflectometer (FWD) and static deflection bowl measurements were taken before, during, and after trafficking to evaluate the structural condition. Finally, pavement samples were obtained from the section and tested in the laboratory. The pavement response was analyzed and validated with a model using the Finite Element Method (FEM). At the end of the tests almost no sign of distress was observed, showing the durability of the pavement.


This study aims to determine the peer-counselling skills profile who are the members of PIK R (Youth Counselling Information Center), Educational Pathways in Depok. This research used a quantitative approach with a survey method. The samples were selected by using non-probability sampling, saturation sampling technique applied. The sample of the research is all the members of PIK R Educational Pathways in Depok. The respondents are from public junior high school of SMP Negeri 1 (13 students), public junior high school of SMP Negeri 2 (12 students), public junior high school of SMP Negeri 5 (17 students), public vocational school of SMK Negeri 1 (37 students and public senior high school of SMA Negeri 1 (26 students). The instrument used was the Counselor Competencies Scale – Revised consisting of 12 assessment indicators, in which each indicator has 5 statements. Categorization in this study uses a Likert scale with 5 answer choices. The results of the study showed as follows: overall categorization value that the counseling skills of PIK R members exceeding expectations by 25%, meeting expectations by 37%, approaching expectations by 30%, below expectations by 6%, and endangering by 1%. The highest categorization results regarding the peer-counseling skills profile of PIK R members have met expectations of 37%. Therefore, it indicates that the peer counselors of PIK Depok members have knowledge, skills, consistent traits, and they are proficient in counseling skills. The result met the objectives of the Generation Planning Program (GenRe) training activities for peer educators and PIK R peer counselors, namely to improve the knowledge, attitudes and behavior of peer educators and counselors in the GenRe program in managing and developing Indonesian youth PIK, particularly in Depok.


A simple and ecofriendly procedure have been devised for the green synthesis of silver nanoparticles using the aqueous extract of gum tragacanth (Astragalus gummifer), a renewable, nontoxic natural phyto-exudate. The water soluble components in the gum act as reductants and stabilizers. The generated nanoparticles were analyzed using UV-visible spectroscopy, transmission electron microscopy, X-ray diffraction, Fourier transform-infrared spectroscopy, and Raman spectroscopy. The role of gum concentration and reaction time on the synthesis of nanoparticles was studied. By regulating the reaction conditions, spherical nanoparticles of 13.1 ± 1.0 nm size were produced. Also, the possible functional groups involved in reduction and capping of nanoparticles has been elucidated. The antibacterial activity of the fabricated nanoparticles was tested on model Gram-negative and Gram-positive bacterial strains with well-diffusion method. These nanoparticles exhibited considerable antibacterial activity on both the Gram classes of bacteria, implying their potential biomedical applications.


This cross-sectional, descriptive study analyzes the number of women among physician first authors of articles published in the Journal of the American Academy of Dermatology and JAMA Dermatology across a 5-year period.


The excitation of modes and the oscillation kinetics in a ruby laser with concentric external reflectors were studied using an SFR-2M high-speed camera; the radiation spectrum was investigated with a Fabry-Perot interferometer. By studying the distribution of the radiation over the reflectors and in the center of the resonator it was found that in the case of oscillation conditions involving regular damping down to a certain level a large number of high-order transverse modes are excited, whereas only a small number of modes are excited under irregular conditions (depending on the positions of the reflectors, the crystal, and pump energy). The generated frequency bandwidth is 0.5-0.1 cm-1 for a regular regime, and 0.1 cm1 for an irregular regime. The mean frequency usually decreases during oscillation. Besides a smooth frequency variation, 0.1-0.4 cm-1 jumps are observed. These results and those in the literature for regular and irregular oscillation kinetics in solids can be explained on the basis of energy balance considerations when many modes with different quality factors are generated.


Dominant discourses on youth sexual health construct young people as at-risk subjects who engage in risky behaviours due to ignorance or poor decision-making. This dissertation challenges the prevailing assumption embedded in these discourses that young people's sexual behaviours are based on individual rational choices. Drawing on Pierre Bourdieu's theory of practice and R. W. Connell's notion of hegemonic masculinity, this dissertation uses an interpretive approach to analyze the narratives and resonant texts of 24 young men in Toronto. It explores how young men construct and perform their masculine identities in the context of their socio-spatial environment; it also examines the strategies that young men use to compete for cultural capital and dominant positions in the homosocial and (hetero)erotic fields. The analysis yields a number of findings. First, it shows that gender identity is a state of being-doingbecoming. Guided by their gender-class-race habituses, young men engage in an unceasing process of defining, affirming, declaring, and validating not only their sense of who they are (self-identity) and where they belong (collective identity), but also the boundary that


The compound TmCrO4 has been studied with bulk magnetization measurements, Tm M . ossbauer spectroscopy and muon spin relaxation ðmSRÞ: The Cr sublattice in TmCrO4; which orders with a second-order magnetic phase transition at TC 1⁄4 18:75 K; gradually induces magnetic order in the non-magnetic crystal field ground state of the Tm sublattice. r 2003 Elsevier B.V. All rights reserved. PACS: 75.50.Gg; 76.30.Kg


Previous calculations of the low-loss modes of a symmetric cylindrical confocal laser resonator have been extended to the asymmetric case. Diffraction losses are governed by the geometric-mean Fresnel number N m of the two end mirrors and, in the system we consider, by the Fresnel number N o of an output coupling aperture in one of the mirrors. Loss factors and mirror field distributions have been calculated numerically for different N o for N m in the range 0.6 ≦ N m ≦ 2.


We have never before experienced a time when technology was such an integral part of culture. Krout and Mason (1988) studied computers just at the point in history when they were becoming more prominent and available for clinical use. Since that time, computing, as just one facet of technology, has morphed into devices such as laptops, tablets like the iRad, smartphones with wireless accessibility, remotely linked devices, and others. These advances have many of us clicking, swiping, checking in, tweeting, and posting to share information with clients, about clinical practice, and us as therapists.Our attitudes toward and beliefs about technology contribute to our way of being in the world. Such is the case for our clients, particularly those younger than 40, who have grown up in an increasingly digitalized age, and are not just "used" to technology, but expect to use and interact with others through technology. Recent research by Mauskapf (in review) adds further weight to this discussion, introducing and commenting on the use of videoconference technology to conduct music therapy sessions with patients in remote areas of the United States who would not otherwise have access to therapy services. This has created a dilemma for us as professionals - does technology enhance or depersonalize therapy? Does it improve patient experiences or serve as a gimmick, without any significant improvement in process or outcomes? And, even more basically, what kinds of technology are available and how can they be used therapeutically? The latter questions are particularly important given the rate of technological advances and the ease with which children, adolescents and young adults adapt and integrate these changes into their lives.Crowe and Rio (2004) have operationally defined technology for our profession: "In fact, in music therapy it [technology] may involve any equipment, device, or method that systematically fosters the production of or response to music" (p. 283). This continues to be a functional use of the term, since advances in computer applications, smartphones, tablets, and Musical Instrument Digital Interface (MIDI) in the years since could still fit in the "equipment, device, or method" portion of the definition. However, the number of devices and prevalence of technology in the clinic has likely increased for most music therapists since 2004, with the push in healthcare toward computerized communication and documentation.Computing, as a general category of technology, is easily the largest, most pervasive product for practitioners in our field, and can include everything from a desktop computer to a smartphone application, or "app." While not as evident in the literature at this point, computing is present in our field in clinical settings - usually directed by facilities. In the broad field of health care, electronic health records are shaping our documentation practices. It is likely that the vast amount of information available to any member of a health care team at the click of a mouse has significantly affected the way a music therapist might understand the needs of a patient prior to a session. Also, could these advances shape documentation, including written assessments? As such, computing is a mandated skill for any new professional in any setting.Although we may agree that today's technologies can still fall under the definition proposed by Crowe and Rio in 2004, the vast amount of jargon and acronyms can confuse instead of facilitate the learning process. A moment to explain some of the more popular terms in the lexicon is warranted here. Table 1 provides a summary.This is not to say it is useless to discuss technology in terms of tangible items. Have you tuned a snare drum with tripleflanged hoop rims for better sound quality (compared with straight-rimmed predecessors)? Have you noted realness to the synthetic djembe head you recently purchased or used the vibraphone setting on a digital piano? …


Objective To investigate the therapeutic effect of unstable intertrochanteric fracture with PFNA.Methods From December 2010 to January 2012,39 patients with femoral unstable intertrochanteric fracture were treated by proximal femoral PFNA,including 12 males and 27 females,aged 40-86 years old(average 65.8 years old),including tumbling for 28 cases,traffic accident for 5 cases,falling from height for 6 cases,including 25cases of type A2,14 cases of type A3 according to AO classification.The effect was investigated by retrospective analysis.Results 36 cases were followed up for 3-12 months,average 8 months.All wounds healed well,and no postoperative complication occurred.All fracture cases healed well without deformed healing,screw loosening,plate fracture etc.According to Harris Hip Score,the functional recovery of hip was as follows:Excellent(90) 24 cases,Good(80-89) 12 cases,Fair(70-79) 0 cases and Poor(70) 0 cases,and the excellent and good rate was 92.31%.Conclusion PFNA in the treatment of intertrochanteric fractures with simplify surgical operations,small surgical trauma,shorten operating time,bed activity earlier,quick fractures heal,rotate and cut-proof,fewer complications,and other advantages,could be used for the treatment of unstable intertrochanteric fracture of the femur.


Though persistent failure of clinical trials poses a challenge for multiple conditions, traumatic brain injury (TBI) is especially difficult to study because of its heterogeneity, complexity, unpredictable outcomes, and resistance to definition and classification. This article analyzes published discourse among researchers about the failure of two large trials for progesterone as a traumatic brain injury (TBI) treatment. The analysis specifically examines how researchers respond to trial failure and how TBI functions as a diagnostic construct. I draw on theories of kairos and multiple ontologies to argue that, while evidence-based medicine constructs TBI as a coherent entity in order to study it through randomized controlled trials, this entity breaks down in practice into multiple temporalities and spaces that are not sufficiently coordinated.


pg. 1 of 10 Abstract: Applied Photophysics' SX20 Stopped-Flow spectrometer may be used to measure fluorescence changes on the millisecond timescale.The technique can give important kinetic information regarding biomolecular interactions as demonstrated in this application note. Here, the kinetics of Ca2+ dissociation from the messenger protein Calmodulin is measured, observing changes at different temperatures with different variants of the protein. The fluorescence signal is provided by internal Tyrosine residues within the protein.


This paper discusses the use of eigenspace techniques for the design of an active flutter control/gust load alleviation system for a hypothetical research drone. One leading edge and two trailing edge aerodynamic surfaces are available for control. Full state control laws are designed for two combinations of control surfaces by selecting feedback gains which place closed loop eigenvalues and shape closed loop eigenvectors so as to stabilize wing flutter and reduce gust loads at the wing root while yielding acceptable robustness and satisfying constraints on rms control surface activity. These controllers are realized by state estimators designed using an eigenvalue placement/eigenvector shaping technique which results in recovery of the loop transfer characteristics of the full state feedback systems. The resulting feedback compensators are shown to perform almost as well as the full state designs. They also exhibit acceptable performance in situations in which the failure of an actuator is simulated.


Bioremediation is a technology for treating contaminated sites by the use of biological agents capable of modifying or decomposing pollutants. Whereas all plants can host one or more fungal endophytes, and these have great biotechnological potential the work aimed to study the feasibility of using endophytic fungi from Bambusa vulgaris (Poaceae) in the bioremediation of contaminated soils. For that were made soil contamination ex situ with diesel oil, chorume and the herbicide Roundup and fungus in the dilution of 5 x 105 conidios / mL were evaluated weekly the size of colonies and the fungal growth, the calculation of the initial and final volume of the pollutants tested by Tukey test at 5% probability. The endophytic fungus Fusarium moliniforme Sheld had 99% survival in the three contaminants evaluated within 30 days. The chorume had


Abstract 1713 Genomic aberrations like 17p and 11q deletions and mutations in p53 affect survival outcome in CLL. To further our understanding of the anatomy and clinical importance of various acquired genomic copy number aberrations (aCNA) in CLL, we have generated SNP 6.0 array-based genomic profiling data of DNA from sorted CD19+/CD3+ cells from 256 CLL patients, of which 201 were untreated and 55 relapsed (median number of prior therapies 1) at study enrollment. Acquired CNAs were detected using visual inspection of paired (CD19+: tumor/CD3+: normal reference DNA) genomic copy number heatmap displays using the validated software tool dChipSNP. This analytical approach is conservative and has been previously externally validated using FISH for other tumor types and lesions > 0.2 Mb. The range of aCNA for all cases was 0–22 lesions, most of which were sub-chromosomal deletions. We did not detect a sub-chromosomal aCNA in 72/256=28% of the cases even at this ultra-high resolution, suggesting that sub- chromosomal aCNA are not involved in the pathogenesis of this CLL subset. Three or more sub-chromosomal lesions were found in 50/256=20% of all cases analyzed; this is likely a low estimate of the true frequency of this genomic CLL type given the aggressive clinical behavior. Of the 50 cases with ≥3 sub-chromosomal lesions, 26 harbored somatically acquired p53 exon 2–10 mutations (26/50=52%). Next we determined the prognostic importance of various established and novel biomarkers on the clinical endpoint overall survival (OS; alternatively computed using either the CLL diagnosis date or the trial enrollment date as the reference date). For previously untreated patients (N=201) and for the OS analysis based on the diagnosis date and the date of death, OS was 84 months for p53 mutated cases (N=24), 94 months for 17p cases (N=16), 116 months for 11q cases (N=14), 237 months for ZAP70+ cases (N=85), 174 months for IgV H unmutated cases (N=82) and 167, 90 and 52 months for ≥2 (N=68), ≥3 (N=31) or ≥4 (N=19) aCNA based on SNP 6.0 array profiling, respectively. For all patients (N=256) and for the OS analysis based on the diagnosis date and date of death, OS was 96 months for p53 mutated cases (N=36), 91 months for 17p cases (N=25), 123 months for 11q cases (N=25), 139 months for ZAP70+ cases (N=123), 123 months for IgV H unmutated cases (N=116) and 144, 108 and 77 months for ≥2 (N=100), ≥3 (N=50) or ≥4 (N=33) aCNA based on SNP 6.0 array profiling, respectively. Furthermore, CLL patients with wild type p53 exons 2–10 and SNP 6.0 array-based genomic lesion loads of 2 lesions or more had significantly (all p We proceeded with multivariate analyses including various base variables (del17p, del11q, p53 exon 2–10 mutations, ZAP70 status, IgV H status) in the models as well as SNP 6.0 array-based genomic complexity at various thresholds. Furthermore, models were based on previously untreated patients only or alternatively on all patients. Finally, models were based on the CLL diagnosis date or alternatively the CLL trial enrollment date as the reference date for OS computations. Importantly, for all models, genomic complexity emerged as an independent and dominant predictor of short OS. For instance, for previously untreated patients (N=192) and OS based on the diagnosis date in CLL, the hazard ratio (HR) for short OS for genomic complexity ≥3 lesions was 3.95 (CI=1.12-13.95; p=0.03) when controlling for ZAP70 status HR=0.68 (CI=0.25-1.89; p=0.46), IgV H unmutated HR=2.64 (CI=0.91-7.68; p=0.07) and p53 exon 2–10 mutations HR=1.95 (CI=0.51-7.43; p=0.32). For all patients (N=247) the corresponding results were: genomic complexity ≥3 lesions HR=3.57 (CI=1.72-7.44; p H unmutated HR=2.93 (CI=1.39-6.21; p p53 exon 2–10 mutations HR=0.9 (CI=0.4-2.03; p=0.79) with OS based on the diagnosis date. Similar results were obtained when controlling for 17p or 11q status. In summary, this data demonstrates that a subgroup of CLL patients with elevated genomic complexity has poor overall survival (akin to patients with p53 mutations) and thus should be specifically targeted for novel therapeutic approaches. Disclosures: No relevant conflicts of interest to declare.


FIELD: medicine. SUBSTANCE: group of inventions relates to medicine. An intraocular lens delivery system comprises an injector body having a passage surrounded by an inner wall. Further, the system comprises a piston tightly embedded inside the passage. The system also comprises a number of deflectable elements attachable to the body and configured to contact the inner wall and to deflect when the piston is inserted inside the body; the deflectable elements align a rod, and when they are inserted into the injector body promote generating a pre-set force reacting against a piston advancement when the passage deflects. EFFECT: using the presented group of inventions enables the higher effectiveness of surgical procedures. 14 cl, 3 dwg


In this introduction to a series of papers on psychoanalysis and scientific research that will be published across three issues of this journal, the author sets the stage by highlighting the urgency of the questions being debated. What we mean by science and research, validation, quantitative and group statistical measurement are shown to reflect historical, cultural, social, political, and economic factors. Ultimately this debate is not only about science and hermeneutics, positivism and constructivism, but about the future of psychoanalysis as well as our humanistic and moral values.


2014 We present in this paper several theoretical results about three-photon absorption using an expansion of the transition operator on an irreducible tensorial set basis. We deduce the selection fules and some results about the calculation of the line intensities. LE JOURNAL DE PHYSIQUE TOME 40, OCTOBRE 1979, Classification Physics Abstracts 32.80K 33.80K In the recent years, because of the development of high-intensity tunable dye lasers there has been a large experimental interest in the processes of three-photon absorption [1]-[4]. Three-photon excitation has demonstrated to be a powerful tool in high resolution spectroscopy [1], it is also a very accurate way to populate excited states which cannot be reached by one and two-photon transitions [3]. We present here some results about the selection rules and line intensities in three-photon absorption. These results are an extension of the results previously demonstrated in the case of two-photon absorption [5][9]. The average transition probability between a nonpolarized ground state of angular momentum Jg and an excited state of angular momentum Je in a resonant three-photon transition is equal [9] to : where Te is the lifetime of the excited state, EE cos (cvt kr) is the electric field of the exciting light and Qeu is equal to : D is the electric dipole moment and Ho is the Hamiltonian of the free atom (the energy of the ground level g is taken equal to 0). It is sometimes useful to divide the exciting beam into three beams of equal frequency. Such a scheme is used, for instance, in order to eliminate the Doppler broadening in three-photon transitions [1], [10]. If we assume that the three beams are described by plane waves Ei Fi cos (wt ki r), the absorption of three photons is described by a formula similar to (1) : the three-photon operator corresponding to the absorption of three-photons of different directions is : The sum is performed over all the permutations of the polarizations. The operator QÈI£2£3 is thus completely symmetric (QElEZE3 = Q:P(1)£P(2)£P(3). We now discuss QS03B5103B5203B53 S03B5p( )03B5p(2)03B5P(3)). We now discuss which are the consequences of this symmetry. We want to expand QE1E2E3 on a tensorial irreductible set basis. The Q£1E2E3 operators form a set of tensorial operators of rank inferior or equal to 3. Indeed QSE103B52E3 is obtained by coupling three times the vectorial operator D and twice scalar operators (1ïw HO) 1 and (2 hW HO) 1. In order to determine the ranks of the operators in this expansion, we note that the present problem is very similar to the one encountered when one wants to expand a symmetric state of three particles of spin 1 on a basis corresponding to the eigenstates of the total momentum J. This problem is easy to solve : there are only two states corresponding to the values 3 and 1 of J which are completely symmetric. This result can be demonstrated as follows : if we consider three spins 1, Article published online by EDP Sciences and available at http://dx.doi.org/10.1051/jphys:019790040010096500


The gauche/trans conformational equilibria of 2,2'-bi-1,3-dioxanyl (1), 2,2'-dimethyl-2,2'-bi-1,3-dioxanyl (2), 2,2'-bi-1,3-dithianyl (3), and 2,2'-dimethyl-2,2'-bi-1,3-dithianyl (4) dissolved in carbon tetrachloride and benzene are studied through dipole moment determination. Analyses of the relative permittivity data show that the dioxa system favors the trans form at 25 °C. Replacement of the oxygen atoms in 1 with sulfur completely reverses the gauche/trans equilibrium in carbon tetrachloride such that 3 exists predominantly in the gauche form. However, 4 exists mainly in the trans conformation in carbon tetrachloride solution and both 3 and 4 favor the trans form in benzene. X-ray crystallographic determination revealed that 1−4 favored the trans conformation in the solid state. Ab initio and DFT calculations were performed to examine the structural features of 1−4 and study the effects of solvent on these molecules. The calculated gauche/trans equilibria of 3 in different media are in excellent acco...


I would like to use this opportunity* to try and illuminate sorne striking characteristics of the imperial world system we live in today. It concerns, especially, fundamental characteristics of a new political movement (a "mass conservatism") born in the USA during the seventies and which, in 1980, with president Reagan, took over the USA government. From there this movement spread out fast to large parts of the Western world. This development has been accompanied by boundless chauvinism and new myths of violence and war that are without comparison since the twenties and thirties, and find fertile soil in the frustrations of a lost war. They unite with an extreme anti-interventionist neo-liberalism, that needs arbitrary violence for its total market policy which cannot be imposed without it. The economic interests together with the situation of frustration lead to a myth of rearmament, linking the unimpeded economic liberalism and the rearmament to a new utopia of peace and a new millenial messianism, in which the mysticism of the Millenium is injected precisely by the Christian fundamentalism that has developed in the USA over the last century. For this messianism, the USA as an imperial center, are a center of power that divides the world in friend and enemy and acts accordingly. Thus grows a power which is deducted in a new sense from the possession of nuclear arms. Nuclear arms stop creating a nuclear stalemate once a nuclear power succeeds in making believe that it is prepared to use such arms and thus is prepared to collective suicide. As long as the rest of humankind is not of the same attitude, it will be in a complete


J am grateful to Taljedal for our refreshing discussion in this journal (1, 2, 3). I think we are coming much closer to a shared picture of the issue. We are coming to see where we have substantially different views and where there have just been misunderstandings. In this counterreply let me just direct the reader's attention to some important conditions for philosophical conceptual work which may be overlooked in brief criticisms of results of such work. I agree, of course, with Taljedal when he claims that no theory and no definition is immune to criticism. Criticism is the nerve of the whole scientific enterprise. A fortiori I must welcome any criticism of my own attempts at theories and definitions. I do indeed welcome such criticism and I have learnt a lot from it. At the same time the'person to whom the criticism is addressed must be allowed to point out when he or she thinks that the criticism has little force because it is not based on all relevant premises. An important point in the present case is that my definition of health in terms of the subject's abilities and vital goals should not be judged in isolation. The concept of health as I'have characterised it is part of a conceptual network where several other important medical concepts, such as malady, disease, impairment and defect, have a place. My standpoint is that health is logically prior to these other concepts and that the latter should be defined in relation to the former. By taking this stand I am proposing a theory which is the direct opposite of an important alternative presented by the American Boorse, who starts his construction on the level of organs and with the, concept of disease. As a professional philosopher I am then primarily expecting a critical assessment of my construction as a whole. Is my conceptual network us a whole doing a better job than Boorse's or someone else's? (4) I think that the situation is similar in natural science. Scientific theories are evaluated on their total strength. Criticisms of details for instance, on intuitive ,grounds have little weight if the whole theory makes better sense than all presented rival theories. This does not preclude, of course, that one should take care of a detailed objection if it can be easily encompassed in the whole structure.


The behavior of O atoms in Ti film is investigated under high-flux, low-energy molecular water ion implantation. After 10 min of irradiation at room temperature, the anomalously deep penetration of oxygen without formation of new chemical compounds observable by XRD has been registered in Ti films using Auger spectroscopy analysis. It is shown that the surface energy increases under ion irradiation, and the relaxation processes minimizing the surface energy initiate the redistribution of atoms. Two surface energy relaxation processes are considered: (i) the mixing of atoms on the surface resulting in annihilation of surface vacancies; and (ii) the annihilation of surface vacancies by atoms transported from the bulk. The theoretical considerations are in agreement with the experimental results if to assume that the mass-transport in the bulk is controlled by the processes on the surface and the adsorption of reactive atoms or molecules leads to local and long-range restructuring and adatom relocation at the surface.


Electron microscopy and dynamic mechanical spectroscopy (DMS) techniques were used to study the morphology and glass transition behavior of simultaneous interpenetrating networks (SIN's), based on three different castor oil derived elastomers, and polystyrene (PS) plastic erosslinked with 1 percent divinyl benzene. The castor oil elastomers consisted of either the sebacic acid polyester, 2,4-tolylene diisocyanate polyurethane, or the mixed poly(ester-urethane). Emphasis was placed on two compositions having 10 and 40 percent elastomer contents by weight of each type, the remainder being PS. In all cases, a two-phase morphology emerged. With the 10 percent elastomer composition, the use of vigorous stirring during the early stages of reaction resulted in materials having the crosslinked polystyrene as the continuous phase and elastomer domains (ranging from 100 to 8000 nm in size) as the discontinuous phase. The elastomer domains contained a polystyrene cellular structure, with the polystyrene cell sizes ranging from 50 to 300 nm size. Several examples showed morphologies resembling high impact polystyrene. Materials having a 40 percent elastomer content always showed a continuous phase of castor oil elastomer, with the PS displaying a bimodal size cellular structure. Domain sizes ranged from 10 to 860 nm. The DMS studies showed two well-defined glass transitions near their respective homopolymer glass transitions, but shifted inwards to greater or lesser extents indicating some molecular mixing between the two polymers. The glass transition of the pure elastomer phase occurred at −66°C for the castor oil polyester elastomer, −4°C for the castor oil polyurethane elastomer and −50°C for the castor oil poly(ester-urethane) elastomer. Phase separation in these materials is postulated to occur by two mechanisms: (1) multiple precipitation of polystyrene chains at progressive levels of polymerization and (2) microsyneresis processes. The thermodynamics of mixing and phase separation in polymerizing SIN's is examined in some detail.


Outcrop work represents the main source of analogs used to model subsurface reservoirs. Without such explanation of reservoir geometry, architecture, and characterization, producing subsurface formations would be largely uncertain. The aim of this paper is to build a geological static model for the Enjefa Beach outcrop exposed in Kuwait and use it to better understand subsurface reservoir architectures. This was achieved by acquiring several traverses along the outcrop, describing the various rock units, and understanding the depositional facies and facies associations. The next stage was to model each depositional unit as a separate zone embedded in an integrated model. This was followed by developing a forward synthetic three-dimensional seismic model to better understand how such reservoir architecture may appear in the subsurface. The final step was to use these findings in modeling a subsurface Cretaceous reservoir in northeastern Kuwait. The resultant model demonstrated that detailed geological complexities can be captured by conventional modeling techniques; in the model, the middle shoreface, upper shoreface, foreshore, and tidal channel complexes were statically modeled. Subsurface seismic data showed a series of highly sinuous meandering channels. Stacking patterns were found to vary among vertical, climbing, and compensational stacking patterns.


AbstractBackground: Dengue haemorrhagic fever (DHF) is an endemic disease that has a high incidence and mortality rate in Indonesia. Implementating clinical pathways (CP) in hospitals can be used as the basis for treating patients with DHF so as to improve service quality and minimize complications. Objective: This study aims to evaluate the implementation of CP DHF in the pediatric unit at Type D Private Hospital in Yogyakarta. Methods: This is a mix method research with case study design. Qualitative data was collected through in-depth interviews and observations of pediatricians n=2), nurses (n=3), directors of medical services (n=1) and medical committees (n=1). Quantitative data was collected through document review and interviews with the Integrated Clinical Pathway Appraisal Tools (ICPAT). Results: Documents is true a CP. The role of the organization has been running well. The process of documenting, developing and implementing CP DHF is not optimal. The maintenance process is bad. Compliance completes of CP DHF is 9%. The majority of lenght of stay are above 3.86 days with treatment costs above the BPJS package. The incidence of complications is low. The obstacles found during the implementation of CP DHF were that the patient did not have access to CP, low adherence to CP and human resource management factors. Conclusion: The development and implementation of CP DHF needs to be improved both in terms of content and quality. Strong policies are needed, good organizational support and the active role of clinicians are the keys to the successful implementation of CP.Keywords: Clinical Pathway, Dengue Haemorragic Fever, Integrated Services


THE report of the Committee on Sedimentation for the two years 1930–1932 has been published under the auspices of the Division of Geology and Geography of the U.S. National Research Council as National Research Bulletin No. 89, 1932 (pp. 229, price 1 dollar). The report is by the chairman, Prof. W. H. Twenhofel, who contributes a general introduction, and various committee members and others, who are responsible for many valuable records of original research and abstracts of literature on the accessory minerals of igneous and sedimentary rocks. Special attention deserves to be given to the paper on the classification and terminology of the pyroclastic rocks by C. K. Wentworth and Howel Williams. The Bulletin also includes papers on recent advances in the study of peat; recent marine sediments; settling of bentonite in water; relation of the buffer mechanism of sea water to the solubility of calcium carbonate; modern marine sediments in California; bacterial and chemical factors in lime deposition at Tortugas, Florida; varved sediments; chert and flint, concretions, and cone-in-cone; abrasional work of river ice and of glaciers; ground water hydrology in its bearing on sedimentation; rôle of micro-organisms in sediments; accessory minerals of crystalline rocks; and glacial sediments. In addition, there are summaries of work on sedimentation carried out at Stanford University, and also of recent work by German and British investigators; and abstracts of the literature on accessory minerals of igneous rocks and of sedimentary rocks.


This volume presents the proceedings of the workshop organised by the Directorate-General for Economic and Financial Affairs (ECFIN) jointly with the European Stability Mechanism (ESM) and the German Council of Economic Experts (GCEE) on 19 September 2017 in Brussels. The workshop aimed at raising awareness about the fiscal policy architecture in Europe and its potential future developments and contributing to the expert debate on these issues. It consisted of two sessions with two panels each. Short presentations of expert or research contributions were followed by a debate with the audience. The first session was devoted to a review of the European experience with fiscal policy coordination and governance, including perspectives on the euro area fiscal stance. The second session focused on fiscal risk sharing and stabilisation in the euro area. It explored different options of a fiscal stabilisation function and their design.


The simulated training is an important issue for any type of missions such as aerial, ground, sea, or even space missions. In this paper, a new flexible aerial simulator based on active hybrid architecture is introduced. The simulator infrastructure is applicable to any type of training missions and research activities. This software-based simulator is tested on aerial missions to prove its applicability within time critical systems. The proposed active hybrid architecture is introduced via using the VB.NET and MATLAB in the same simulation loop. It exploits the remarkable computational power of MATLAB as a backbone aircraft model, and such mathematical model provides realistic dynamics to the trainee. Meanwhile, the Human-Machine Interface (HMI), the mission planning, the hardware interfacing, data logging, and MATLAB interfacing are developed using VB.NET. The proposed simulator is flexible enough to perform navigation and obstacle avoidance training missions. The active hybrid architecture is used during the simulated training, and also through postmission activities (like the generation of signals playback reports for evaluation purposes). The results show the ability of the proposed architecture to fulfill the aerial simulator demands and to provide a flexible infrastructure for different simulated mission requirements. Finally, a comparison with some existing simulators is introduced.


The T- and NK-cell neoplasms are a heterogenous group and are relatively uncommon. From the International Non-Hodgkin's Lymphoma classification study, precursor T-lymphoblastic lymphoma and the mature T- and NK-cell lymphomas account for 1.7% and 12% of all NHLs. T-NHL are in general more common in Asia. The outcome of this disease is poorer with a 5-y overall survival of 20% (excluding anaplastic NHL). Hospital Kuala Lumpur is the major hematology referral centre in Malaysia. A total of 414 new cases of lymphoma was seen during 2000–2005. The majority were DLBCL 46% and follicular grade I/II lymphomas 15.8%. Only 48 cases (12%) were T-NHL. These were PTCL 19 (5%), anaplastic T-NHL 9 (2.2%), cutaneous T-NHL Stage IV 9 (2.2%), T/NK-NHL 5 (1.2%) and angioimmunoblastic NHL 3 (0.7%). Between 2002–2005, 15 patients were treated with HyperCVAD regimen alternating with Mtx/Ara-C. Three had T-lymphoblastic lymphoma, 7 had PTCL and 5 had T/NK cell. The complete remission was 40% with two proceeding to stem cell transplant. One received local DXT. The median duration of remission was 18.5mths(10–30mths) with median follow-up of 30mths(25–35mths). Alemtuzumab(Campth-1H) is a humanised monoclonal antibody that targets the CD 52 antigen including the T-cell. We combined HyperCVAD with Alemtuzumab 30mg sc on day 1 of every chemotherapy cycle. Four patients with relapsed/refractory T-ALL and 1 patient with T/NK NHL were treated. Two patients, one who relapsed six months after chemotherapy and the other after allogeneic transplant achieved complete remission. The patient with T/NK who had progressive disease with enlarging hepatosplenomegaly after 1 pair of HyperCVAD achieved remission after the addition of Campath. The median duration between each chemotherapy cycle was 25 days(23–26d). One patient had CMV reactivation with no evidence of disease. All patients are still undergoing treatment. The addition of Campath 30mg on day 1 of each chemotherapy cycle appears to be a viable option to try to improve the results in aggressive T-NHL. In view of these preliminary findings, we are starting a study protocol using Campath plus HyperCVAD in aggressive T-cell disease.


This presentation focuses on the Repertoire International de Litterature Musicale (RILM) search interface. RILM is an online music bibliography. Through screenshots of the interface and instructions, the presentation highlights different features of RILM's database and how to get the most accurate results based on your search topic. This presentation was given at the Music Library Association Conference on February 12, 2004,


There have been many clients using cloud computing in recent years, ranging from small businesses to large corporations. The tremendous amount of information and resources that cloud organizations must handle has created challenges. Managing resources inefficiently can lead to poor performance in cloud computing. Diverse stakeholders need resources allocated equally to meet their needs without sacrificing the company's financial success or user satisfaction. If the assets are not available on the list, a customer's request cannot be withheld indefinitely. To make IoT devices more energy-efficient, we utilize nonorthogonal multiple access (NOMA) technology to handle vast amounts of data. IoT devices have been designed to achieve maximum energy efficiency while allowing for maximum tolerable delay requirements by formulating a joint resource allocation problem that considers both intracell and intercell interference. We partitioned the problem of resource allocation for radio and computing to start addressing this interactable mixed-integer nonconvex problem. Further divisions of this radio resource allocation are Subchannel allocation, which can be addressed using a matching technique, and power allocation, which uses a sequential convex programming algorithm. With the use of the knapsack algorithm, computation resource allocation can be obtained. we mainly focus on minimizing the delay and increase the energy efficiency. The simulation results demonstrate the effectiveness of the suggested NOMA technique.


This article's subject offers an opportunity for studying the dynastic relations and marital practices of Ptolemy I as well as Antipater, in addition to related issues concerning early-Hellenistic chronology and genealogy. In this context, the date of the conference at Triparadisus deserves particular attention. Furthermore, I will reconsider the common scholarly assumption that Eurydice was repudiated so that Ptolemy could marry Berenice and favor her son Ptolemy II over Eurydice's eldest son Ceraunus. This study moreover intends to reveal some of the fallacies underlying modern scholarship – especially the misguided believe that Ptolemy I practiced serial monogamy. In an addendum I should submit a few (minor) corrections to previous articles on the related issues of Ptolemy's marriage to Berenice and the birth of their daughter Arsinoe (II).


A competitive mathematical model for the growth of two species is considered in this study. The main goal of the present study is to investigate the roles of two different growth functions: the logistic growth and the food limited growth. We established the main results that determine the asymptotic stability of semi-trivial as well as the coexistence solutions. If higher carrying capacity is embodied for the population following logistic growth then competitive exclusion of a food limited population is imminent and vice versa. GANIT J. Bangladesh Math. Soc. Vol. 37 (2017) 111-119


Preliminary studies (Davies et al., 1964) have indicated that 1-AH has a selective antiviral activity against a number of laboratory strains of influenza virus. The compound appeared to act by blocking virus penetration and evidence of viral inhibition was obtained in both tissue culture and animal experiments. Since 1-AH is highly soluble, relatively non-toxic and biologically stable it merited further extensive investigation. The object of the present studies was firstly, to compare a number of different human and animal strains of influenza A virus in their degree of sensitivity to I-AH in tissue cultures and in the experimental infection of mice. Secondly to investigate the spectrum of activity of the compound in tests with other myxoviruses and representative strains of other virus families. Thirdly, to study quantitative aspects of inhibition in vitro with a highly sensitive virus strain (A2/Scot/49/57) and a strain of moderate sensitivity (NWS virus).


Irregular one-set must be non-connectional,but regular one-sets can be connectional or non-connectional.This paper constructs a kind of fractal sets satisfying non-connectional and regular one-sets from "rectifiable curve"


The author examines one of the main reasons for the inefficiency of the activities of state joint-stock companies in the Russian Federation. Largely due to the presence of corruption and abuse in governing state joint-stock companies their activities are not as effective as they could be. There is a wide variety of variations in the study area. Among them: unreasonable expenses, purchases of works, goods and services at inflated prices, various forms of abuse of movable and immovable property, reorientation of some of the consumers of products to the CEO's parallel personal business, hiring employees whose hiring is unjustified from a commercial point of view


A HRPD / 3GPP EPC network connection device, provides a system and method. An apparatus, system and method includes a user equipment, and the HRPD network including HSGW, and a 3GPP EPC network including at least one gateway. The user apparatus detects the need to establish a connection with the 3GPP EPC network, determining an APN value that corresponds to the 3GPP EPC network, included the APN value in a connection request, a communication connection request to the HRPD gateway of an HRPD network configured to. HRPD gateway receives the connection request from the user device, determine a PDN gateway of the 3GPP EPC network corresponding to the APN value in the connection request, it is configured to allow a connection between a user device and a 3GPP EPC network that. .FIELD 4


baik (2) ada perbedaan prestasi matematika antara dengan self efficacy tinggi, self efficacy self (3) tidak Abstract This research is aimed to know: (1) Which learning did give better mathematical achievement, cooperative learning which is typed Think Pair Share (TPS) or conventional learning. (2) Did the students with higher self efficacy have better learning achievement in mathematics than the students don't. (3) Are there any differences in learning achievement in mathematics from the students with higher self efficacy and the students with lower self efficacy in TPS learning model and conventional learning model. This research is quasi-experimental. The populations are all students grade X mechanical automotive in Sukoharjo region. The technique of data analysis used is test analysis variation two ways with unequal cells. The conclusions are that: (1) TPS learning model produced better learning achiement than conventional model; (2) there are any differences learning achievement in mathematics from the sudents that have higher self efficacy, averege self efficacy and lower self efficacy; (3) There is no interaction between learning model with the students' sefl efficacy toward learning achievement in mathematics.


The workshop Rift Valley Fever Vaccine Development, Progress and Constraints was organized by the Food and Agriculture Organization of the United Nations (FAO) and the Central Veterinary Institute of Wageningen University and Research Centre, under the umbrella of the Global Framework for the Progressive Control of Transboundary Animal Diseases, a joint initiative of FAO and the World Organisation for Animal Health. The workshop was supported by the Netherlands Ministry of Economic Affairs, Agriculture and Innovation, and by the US Centers for Disease Control and Prevention; other participants included the World Health Organization and the International Atomic Energy Agency. The meeting occurred January 19–21, 2011, at FAO headquarters in Rome, Italy, and was attended by 34 leading scientists in Rift Valley fever virus (RVFV) vaccine development, representatives of international organizations, and policy makers. Stakeholders from industry were represented by the International Federation for Animal Health. The main objective of the meeting was to gain consensus about desired characteristics of novel veterinary RVFV vaccines and to discuss how incentives can be established to ensure that these vaccines come to market.


---. IN DEFENCE OF CANADA, III, "PEACEMAKING AND DETERRENCE." Toronto: University of Toronto Press, 1972, 448 pp., Can$ 17.50. Gray, Colin. CANADIAN DEFENCE PRIORITIES: A QUESTION OF RELEVANCE. Toronto: Clark Irwin, 1972, 293 pp. McLin, John. CANADA'S CHANGING DEFENCE POLICY, 195763: THE PROBLEMS OF A MIDDLE POWER IN ALLIANCE. Baltimore: Johns Hopkins University Press, 1967, $12.50. Stairs, Dennis. THE DIPLOMACY OF CONSTRAINT: CANADA, THE KOREAN WAR, AND THE UNITED STATES. Toronto: University of Toronto Press, 1974, 373 pp., $15.00. Warnock, John. PARTNER TO BEHEMOTH: THE MILITARY POLICY OF A SATELLITE CANADA. Toronto, Chicago: New Press, 1970, 340 pp.


Abstract Within an affiliated value auction setting, we study the relationship between the number of bidders and the winner's curse in terms of its frequency of occurrence and its expected harm. From a design perspective, we find that both the number of bidders and the level of affiliation are instrumental when choosing an auction format and whether to encourage or discourage bidder participation.


High molecular weight, soluble poly(benzoyl-1,4-phenylene)s (η inh =0.99-1.6 dL/g) have been prepared by nickel-catalyzed polymerization of 2,5-dichlorobenzophenone in the presence of excess zinc and triphenylphosphine (PBP-A). Polymerization with 2,2'-bipyridine as coligand produces a soluble polymer (PBP-B) which exhibits a higher glass transition temperature of 217 o C (versus 149 o C for comparable PBP-A), a UV-vis λ max at 352 nm (versus 328 nm for PBP-A), and only two 13 C NMR peaks in the carbonyl region at 1966-198 ppm (versus an additional peak at 196.3 ppm for PBP-A). It has been proposed that these two polymers differ in the regiochemical placement of the lateral benzoyl groups along the chain, with PBP-B exhibiting more regular head-to-tail structures.These soluble polymers show no evidence for crystallinity by DSC or by WAXD and exhibit high thermal stability (only 3% weight loss in air or N 2 on heating to 500 o C). Film samples show tensile moduli of 6.4 GPa and tensile breaking strengths in the range of 0.9 GPa


Abstract : The temperature dependence of card-gap sensitivity and failure diameter of a plastisol-nitrocellulose propellant and a polybutadiene propellant containing RDX have been determined. The card-gap sensitivity increased and the failure diameter decreased for the PNC propellant. Neither of these values showed much change, if any, for the RDX-containing PBAA formulation. These results agree with those previously obtained at these Laboratories. (Author)


Each year over 1 million children are affected by divorce. Although usually considered a sociological problem, divorce is a major crisis for those involved, and the effects clearly have implications for mental as well as physical health. For children, the changed relationships with both parents and altered support systems and lifestyle disrupt psychosocial development.Only in the past 10 years have researchers begun to study systematically the short- and long-term effects of divorce on children. This paper presents an overview of the current research literature on children and divorce and describes children's responses at various developmental stages, including acute reactions and effects over time. Awareness of these findings enables pediatric nurses to make appropriate assessments and interventions for children of divorce.


In this article we assess, from a critical realist perspective, the role played by replication in theory development. We first present a concise review of critical realism and then reply to the objection that replication is not possible in the social sciences. We go on to classify replications into six types along two dimensions. Finally, we present a detailed argument for the significance of replication in social science research and propose a multifocal pattern of knowledge accumulation to be integrated with the scattered pattern commonly found in organizational science.


In his admirable study of the career and art of John Lyly, G. K. Hunter chronicles the sad but inevitable transformation of the early Humanist " dream of learning as politically effective " 1 to the reality in the 1570's and 1580's of the Humanist's role of court entertainer. What was often exploitation of the Humanist's abilities in learning and eloquence as the voice of statecraft in the reign of Henry VIII became in Elizabeth's reign the casting of the Humanist in the role of provider of witty, happily artificial diversion. Such diversion, in the court drama for example, tended to reflect the ideals of order and stability carefully nurtured and maintained in the outward show of the Queen and her courtto reflect, in one way, what was usefully acknowledged as being true or within the realm of the possibly attainable rather than what was actually the state of affairs or, conversely, the affairs of state. Any discussion of Lyly's achievement must take into account the work of Lyly's great predecessor at court, the choirmaster, " impresario, playwright, and composer," 2 Richard Edwardes. Yet, it is difficult to trace a direct line of development from Edwardes to Lyly:


Li et al. describe a novel role for IRF2, previously known as a negative regulator of type I IFN signaling, in protection of mice from lethal viral neuroinvasion by facilitating the proper localization of B cells and antibodies to the central nervous system.


Cometary tails relationship to interplanetary gas properties and solar wind velocities deduced from observation of type I ionic cometary tails


Indonesia's educational landscape has changed in the last two decades. The pressures of globalization have led to the rising popularity of international education offered by international schools, which purport to nurture 'global citizens' who are internationally minded and skilful at engaging with the Other. This article explores the role of an international school in Indonesia in educating young people towards a peaceful existence amid diversity. It focuses on the experiences of children from local elite and upper class families. The author argues that the processes of becoming 'international' are embedded in national and transnational class structures. Becoming 'international' overlaps with becoming Westernized and represents a way for the elite to reinforce their status in Indonesia. At the same time, students learn to engage with others even as their experience of difference at the international school amplifies their sense of being 'Indonesian'.


Entrepreneurship is the engine of economic development of each country. The above facts indicate that entrepreneurship should be given special attention and it should constantly be developed. As one of the possible directions of development of entrepreneurship in recent decades, the development of women entrepreneurship stands out. Although in most countries of the world it is believed that women are less capable for entrepreneurship than men, and despite the fact that the majority of large enterprises are managed by men, a rise of women entrepreneurs in the world has been noticed, especially in developing countries. And in recent years in Serbia the number of companies headed by women has increased, so it is now about 25%, which means that women control or manage every fourth company in Serbia. As reasons for this increase we could cite the change of consciousness among women and that they can be just as successful in leading the company as men, but also the fact that starting their own business can supplement their income and improve themselves through self-employment, increase their independence and be more respected in society. Although women are forced to fight in today's world to be recognized not only as women-mothers but also as successful women-entrepreneurs, their determination, perseverance, willingness to take risks and all the problems which entrepreneurship brings, show that the time of women's entrepreneurship is yet to come.


Sulistiowati, 000210401029, Juni 2006. Syntactical Errors Made by the Second Year Students of MAN 2 Jember in the 2004/2005 Acad emic Year in Writing A Descriptive Paragraph. Thesis, English Education Program, Language and Art s Education Department of the Faculty of Teacher Training and Education of th e University of Jember. The Consultants : I. Dra. Siti Sundari, MA. II. Dra. Made Adi Andayani. T ME.d The


The recent completion of the Human Genome Project has made possible a high-throughput "systems approach" for accelerating the elucidation of molecular underpinnings of human diseases, and subsequent derivation of molecular-based strategies to more effectively prevent, diagnose, and treat these diseases. Although altered phenotypes are among the most reliable manifestations of altered gene functions, research using systematic analysis of phenotype relationships to study human biology is still in its infancy. This article focuses on the emerging field of high-throughput phenotyping (HTP) phenomics research, which aims to capitalize on novel high-throughput computation and informatics technology developments to derive genomewide molecular networks of genotype–phenotype associations, or "phenomic associations." The HTP phenomics research field faces the challenge of technological research and development to generate novel tools in computation and informatics that will allow researchers to amass, access, integ...


This study aims to determine how much influence the management accounting information system has on managerial performance with decentralization as a moderating variable at PT. Perkebunan Nusantara II (Persero) Tanjung Morawa. This study uses quantitative associative methods and data collection in this study using primary data with 40 respondents. Data analysis techniques in this study using Smart PLS. The results show that management accounting information systems have an effect on managerial performance, and decentralization strengthens the effect of management accounting information systems on managerial performance.


Electrical Resistivity Tomography (ERT) investigations were carried out on various periglacial landforms in the periglacial belt from Southern Carpathians. Geo-electrical soundings reveal the existence of permafrost in rock glaciers from Retezat Mountains, the depth of active layer, typical internal structure of periglacial deposits and the freezing regime of the sediments inside earth hummocks. The application of ERT investigations proves to be a useful geophysical method to detect the contrast between unfrozen sediments and ground ice from periglacial environments subsurface.


We develop a new objective function for word alignment that measures the size of the bilingual dictionary induced by an alignment. A word alignment that results in a small dictionary is preferred over one that results in a large dictionary. In order to search for the alignment that minimizes this objective, we cast the problem as an integer linear program. We then extend our objective function to align corpora at the sub-word level, which we demonstrate on a small Turkish-English corpus.