We provide strong numerical evidence for a new no-scalar-hair theorem for black holes in general relativity, which rules out spherical scalar hair of static four dimensional black holes if the scalar field theory, when coupled to gravity, satisfies the Positive Energy Theorem. This sheds light on the no-scalar-hair conjecture for Calabi-Yau compactifications of string theory, where the effective potential typically has negative regions but where supersymmetry ensures the total energy is always positive. In theories where the scalar tends to a negative local maximum of the potential at infinity, we find the no-scalar-hair theorem holds provided the asymptotic conditions are invariant under the full anti-de Sitter symmetry group.


Three dimension terrain is one of the hot research subjects at present.It can be used widely in many domains,such as terrain walkthrough,land use planning and 3D geographic information system.This paper is based on the platform of MAPGIS and takes Anze County in Shanxi Province as the example.The technical process of three dimension terrain is proposed.The construction of DEM,texture generation and the production of three-dimensional scene are introduced in detail.The system has realized roaming,recording,palying and geo-science analysis.


Currently, there is a marked tendency towards improvement of early detection of breast cancer that allows patients at extremely low risk for developing recurrent disease to be identified. Therefore, it is necessary to search for biological markers of unfavorable prognosis for patients with hormone-dependent breast cancer. In order to introduce these markers into routine clinical practice, they should be validated in welldesigned clinical studies, provide additional predictive information and be easily reproducible. The standard immunohistochemical parameters (estrogen and progesterone receptors and Ki67 cell proliferation index) can be served as these markers. However, the dynamic changes in these parameters during hormone therapyrather than their initial expression levels in the tumor are of great significance for the individualized hormone therapy.


Formerly a professor in a department of textology and currently in a department of literary theory, Mieke Bal's interests lie within current trends in structuralist and semiological studies. Because her theoretical and pedagogical activities are closely connected, her book combines concept and method, showing how her theories might actually be applied in a literature classroom. In a long introduction Bal sets forth the goal of her book: to make a contribution to the study of narrative signs by demonstrating how the "narrativity" of a roman brings its part to the signification of a total text. To this end she provides a list of definitions which are qualified as provisory and operational. Narrative phenomena are said to be determined by a triplicate stratification, specifically characteristic of narrative, as opposed to poetic or dramatic. It is through these phenomena which act as signs that unperceived meanings (signifieds) may be revealed. Thus, "narratology" is the science (French sense of the word) which seeks through a study of narrativity to formulate the theory of the relations between the three levels of narrative— récit, histoire, texte—and their inclusive levels of narrator, actors, and focalisateur. There is, however, a problem in the study of the narrative, as Bal sees it: critics either fail to evolve clear concepts (Dolezel and Schmid's concept of text, p. 11 ) or they differ with each other to such a degree that one must wonder why. For example, supporting the concept of triplicate narrative structure, Barthes sees the récit as being on the bias of the signified while Genette defines it in terms of the relations between signified and signifier. Bal proposes to define these three levels more clearly by combining certain structural concerns with semiological concepts. Thus, to the structuralist question of, "How does the story become a narrative text?" she proposes a semiological question in answer: "How does the narrative text become a story?" Suggesting that the answer to this second question lies in the special function of the récit, Bal defines récit as the signified of a narrative text (at the linguistic level) which, at the same time, signifies a story which transcends its linguistic ties. Decrying the frequent confusion between the terms text and récit or récit and story, she clarifies her view of the tripartite structure by use of Genette's conception of focalization, to which she adds refinements of her own. Going beyond Genette's precision of the traditional "point of view" to internal and external, Bal sees focalization as including any object of the vue. Thus, she separates the term from narration itself, evolving symmetrical notions of narration—the story in words—and focalization—the multileveled aspects of the vision portrayed. This innovation helps her to separate text, story, and récit by using various degrees of focalization to explain the complex and often ambiguous interplay of linguistic elements in combination with nonlinguistic implications.


idea of a partner's power. The union of wills created the relation, the union of' wills seems necessary to destroy it." Now is the right to execute chattel mortgages upon all the firm property with the intention to kill the partnership, as was done in the Owen v. McGrath and the Nabbett v. White cases inhere-t to the partnership agreement? Did the partnersk4.vest each other by force of the partnership union, with such power? Does it not undermine the one great object contemplated in the partnership agreement, "the sacred bond," as gustice Hoffman says, viz the "furtherance f the partnership objects so long as they car; be attained." The delivery of possession of the property to the mortgagees by one partner without the consent of hs co-partner, is a complete abdication of' his power as a partner, and a termination of' his implied agency on behalf of his copartner. Thus to corclude, we see that the question before us is a very close one, the authorities on the subject being well balanced against each other. The great difficulty in fixing the law is this. The judges on the one hand limit the partner's power because they fear a too far encroachment upon the partner's power. The very essence of partnership requires great latitude to be given one partner and the Courts are cautious about limiting the exercise of the partnership rights* On #he other hand the judges see the unjustness and very apparent unfairness done in giving one partner so rauch power and they thus desire to limit it somewhat without abridging his general right as a partner. CASES CITED OR DISCUSSED. Mabbett v. White 12 N.Y. 443. Clark v. Rives 33 Mo. 579. Hewett v. Sturdevant 4 B. Mon. 453. Cayton v. Hardy 27 Mo. 536. Halstead v. Shepherd 23 Ala. 558. Williams v. Barnet 10 Kas. 455. Stegal v. Coney etc. 49 Miss. 761. Wallace v. Yeager 4 Phila. 251. Drake v. Tlhyng 27 Ark. 228. Myers v. hioulton 12 Pac. 505. Crossman v. Shears 3 Ont. App. 583. Blaker v. Sands 29 Kas. 551. Shellito v. Sarpson 61 Ia. 40. Hunter v. kEayvick 67 Ia. 555. Henderson v. Nichols 67 Cala. 152. Dickinson v. Legare 1 Desaus. 537. Cowen v. McGrath (umreported) Osborne v. Barge 29 Fed. Rep. 725. Union Nat. Bank. Case 136 U. S. 225. Blaker v. Sands 29 Kas. 551. Petter vOrser 6 Bosw. 123.


The published paper by Zhen et al. [Phys. Plasmas 21, 073709 (2014)] contains some errors which have been pointed out in this comment.The published paper by Zhen et al. [Phys. Plasmas 21, 073709 (2014)] contains some errors which have been pointed out in this comment.


Abstract The influence of a fluctuating buoyancy flux at the surface of a linearly stratified sea is studied by means of boundary layer theory. It is shown that these fluctuations cause fluctuating horizontal motions in the top boundary layer. The horizontal divergence of these motions generates vertical motion (Ekman suction) which causes internal gravity waves in the interior of the sea. The amplitudes of these waves are computed in terms of density fluctuations at the sea surface. In case of resonance the growth rate of the amplitude of the resonant wave is obtained. The geophysical significance of this generating mechanism is discussed by comparison with the generation of internal waves by a fluctuating wind field. It seems that the effect of a fluctuating buoyancy flux must not be neglected though it cannot compete with the effect of strong winds.


The invention relates to a novel expanded perlite heat insulation board and a preparation method thereof. The heat insulation board is mainly prepared from the following raw materials by weight: 25-35 parts of expanded perlite, 40-45 parts of water glass, 15-20 parts of a natural mineral additive, and 10-15 parts of distilled water. By employing grain size distribution, pressing molding, sintering, later stage waterproof treatment and other processes, the expanded perlite heat insulation board with good heat insulation performance, excellent mechanical properties, high fireproof grade, high water resistance and high durability can be obtained, and can meet the use demands of building exterior wall heat insulation systems.


Minimally invasive surgery (MIS) has been increasingly used and the continuous
development of technology and instruments allowed the application of this surgical
approach, not only in adults, but also in paediatric and neonatal patients to correct several
birth defects. Since the beginning of its application in adult patients, several studies on the
hemodynamic, metabolic and inflammatory changes during MIS are being extensively
performed, with a special focus on the effects of CO2-insufflation. More recently, concerns
about the impact of the CO2-insufflation over the developing organs and organ systems of
neonates have been published, with brain oxygenation and perfusion the most investigated
events. In this thesis, we aimed to unravel some of these issues and contribute to the
understanding of the impact of the thoracic and peritoneal CO2-insufflation in this sensitive
phase of life, that is the neonatal period.
Surgery leads to specific endocrine, immunologic and metabolic changes but, during MIS,
the isolated impact of CO2-insufflation on these parameters is limited. Studies on animal
models arose as a methodical way to evaluate the impact of CO2-insufflation, by avoiding
confounding factors associated with human studies. Nevertheless, most studies are
performed in adult animals, with only a few studying these impacts on neonatal models.
Additionally, many studies are performed without ventilatory support which is the key player
for the maintenance of normal blood gas partial pressures and pH during CO2-insufflation.
In this work we developed an intubation technique that could be applied in neonatal rats,
allowing respiratory support during CO2-pneumoperitoneum and -pneumothorax. The
adjustments in ventilatory parameters allowed the development of a neonatal animal model of CO2-pneumothorax and CO2-pneumoperitoneum, which was then used to evaluate acute
and long-term impact of CO2-insufflation over neonatal organ systems.
In our anesthetized, endotracheal intubated, mechanically ventilated neonatal rat model, the
impact of the CO2-insufflation over the immune system was evaluated at different levels. The
impact of CO2-insufflation over immune cell populations was evaluated immediately after
CO2-pneumothorax and 4 weeks after exposure, and no major alterations were detected
when compared to control animals, suggesting that CO2-insufflation do not exert a significant
impact on cellular immune system balance. But when evaluating peripheral (serum) and
central (cerebrospinal fluid [CSF]) cytokine response, our findings support that the old
paradigm of an immunologically privileged CNS may not be sustained perioperatively during
MIS surgery, since increased anti-inflammatory cytokine IL-10 levels in CSF were found in
animals submitted either to CO2-pneumothorax or CO2-pneumoperitoneum. The impact of
this finding in the developing brain is still unclear, and further study is needed.
It is known that a single developmental insult in the neonatal period can initiate a cascade
of…


A huge amount of mobile traffic runs on Internet every day. The complex mobile traffic data may degrade the network performance if they are not well managed. As the important foundation of network management, mobile network traffic classification aim to map IP packets into a predefined traffic class set. Most work in this area until now has focused on classification schemes. In contrast, little attention has been paid towards traffic class definition. Various kinds of traffic class lead to difficultly comparing these traffic classification methods. This paper presents a mobile traffic taxonomy based on ontology paradigm. Its meta-characteristic is the mobile traffic communication from users' perspective. It defines mobile network traffic into four levels of categories. And the taxonomy could be used for multiple traffic classification purposes.


The conventional implements utilizing drawbar power through the tractor tyre-soil interface are inefficient mainly due to poor traction efficiency and high wheel slippage. Tractor PTO operated implements have been reported to be more effective in regard to soil cutting ability, pulverization and less draft requirement. Considering the merits, a powered vertical disc plough was designed and developed. The performance was evaluated in rice field (silty-clay-loam) at 15.60% m.c. (d.b) with three levels each of gang speed (70, 90 and 110 rpm), A. i.e. peripheral disc velocity to ground speed ratio λ (4, 3 and 2) and depth of operation (5, 10 and 15 cm). The performance of the implement was found best around 90 rpm of gang speed for λ2 at 10 cm depth of operation in respect of fuel use, draft and wheel slippage, clod size and stubble inversion. The draft ranged between 2.01 to 3.82 kN. The result indicated the possibility of using a bigger size of implement for the same size of tractor.


Incremental redundancy hybrid automatic repeat request (IR-HARQ) scheme used in recent wireless communication standards such as 3GPP LTE provides higher benefits in terms of system capacity and robustness. To map these benefits into system level evaluations is of critical importance. Traditional link abstraction techniques are usually designed for a fixed bandwidth and do not present a generic solution for the variable bandwidth assignment to the users. Therefore in this paper we propose a generic methodology for modeling the IR-HARQ link performance in LTE for the system level simulators. The proposed scheme allows for the arbitrary bandwidth assignments while at the same time reduces the storage requirement for the complex operations of IR-HARQ link abstraction. We apply the proposed methodology to a wide variety of the modulation and coding schemes (MCS) in LTE for a highly frequency selective channel and show that the proposed model provides accurate results.


With the increasing competition of nuclear arms in the world and the newly emerging of nuclear technological research methods,nuclear radiation had resulted in tremendous injuries for human being.How to strengthen the emergency protection and the medical remedy for the nuclear accidents and the radiation injuries had become an important question.Based on the clinical manifestation of the nuclear radiation,the advance on the medicine of prevention and therapy in nuclear radiation accidents in the aspects of combined modality therapy,cytokine,sulfhydryl compounds and herbs were reviewed.The development and utilization of antiradiation drug were prospected.


Wheeled robot is a robot that can run on a flat surface with the help of wheels as a driving medium. The robot is made using Arduino as a programming brain, where the robot can move forward, backward, turn right, and turn left with a smartphone via Bluetooth module. It is controlled via a smartphone as a remote control and Bluetooth HC-05 as a connecting medium between smartphone and robot. In addition to using the Arduino robot, it uses the L298N motor driver as an output regulator for DC motors. Based on the results of testing on this design, in experiment 1, the speed of robot experiment I is 0.58 m/s for a distance of 3 meters completed in 5.1 seconds, in experiment II, the speed is 0.56 m/s with the same distance and completed in 5.3 seconds, and in experiment III, the speed is speed of 5.4 m/s in 5.5 seconds. The difference in speed and duration between experiments is influenced by factors such as reduced battery voltage, and the process of sending data and pairing can be done as far as 13 meters.


Abstract A rapid and efficient methodology was performed for the synthesis of α,β-unsaturated ketones 2a–k containing benzoazonine core through Claisen-Schmidt reaction of the benzoazonine-2,7-dione 1 and various aldehydes in acidic medium. The obtained exocyclic α,β-unsaturated ketones were subjected to an irradiating microwave gave unexpected asymmetric spiro pyran compound 3 via a self-Diels–Alder reaction. The initially formed exocyclic α,β-unsaturated ketones underwent cyclocondesation with phenylhydrazine to afford 2-pyrazoline derivatives 4. The structure of the synthesized scaffolds was characterized using 1H-NMR, APT and 2DNMR spectra. A molecular modeling study using Molecular Operating Environment was performed to investigate their binding modes to the Acetylcholinestrase enzyme active site. Docking results demonstrated that the newly synthesized compounds recognized the active sites of Acetylcholinestrase and form different types of bonding interactions with key active site amino acid residues. Graphical Abstract


In addition to O-type stars, this review will discuss the radio and infrared properties of B supergiants and Wolf-Rayet stars, since it is generally accepted that these objects represent later stages in the evolution of O stars. The radio properties of X-ray binaries which exhibit non-thermal emission will not be discussed. Hjellming (1977) gives an excellent review of the radio properties of close binaries, including X-ray binaries.


Escherichia coli is commonly used as a host for the extracellular production of proteins. However, its secretion capacity is often limited to a frustratingly low level compared with other expression hosts, because E. coli has a complex cell envelope with two layers. In previous report, we identified that the catalytic domain of a cellulase (Cel‐CD) from Bacillus subtilis can be secreted into the medium from recombinant E. coli in large quantities without its native signal peptide. In this study, we proved the N‐terminal sequence of the full length Cel‐CD played a crucial role in transportation through both inner and outer membranes. By subcellular location analysis, we verified that the secretion was a two‐step process via the SecB‐dependent pathway through the inner membrane and an unknown pathway through the outer membrane. However, the N‐terminal region of Cel‐CD is polar and hydrophilic, which showed no similarities to other typical signal sequences. Random mutagenesis experiment suggested that the N‐terminal sequence is a compromising result of transportation through inner and outer membranes. This is the first report that a "non‐classical signal peptide" can guide recombinant proteins out of the cells from cytoplasm. Biotechnol. Bioeng. 2016;113: 2561–2567. © 2016 Wiley Periodicals, Inc.


Curriculum is the core of credit system. The reform of credit system is constrained by the backwardcurriculum. We should realize that higher vocational curriculum reform has the core value in the reform of creditsystem. In reform practice of credit system in the higher vocational colleges, we should pay attention to play the lead-ing role of curriculum reform.


A population of Chionoecetes opilio was studied during the summers of 1980 and 1981 in the southwestern Gulf of St. Lawrence, at the entrance of the Bay of Chaleur, and the Gaspe Bay. Sampling was conducted with beam trawls and baited traps at depths ranging from 45 to 125 m. Crab shell width of both sexes was measured and physiological maturity determined according to a biometrical index. Immature individuals of both sexes are essentially localized on the upper bathymetrical levels, on gravelly mud, whereas adults are found mainly on mud or sandy mud bottoms. We hypothesize that young crabs move down to the muddy bottom where recruitment to the fishery occurs. This deplacement seems to be concomitant with physiological maturity.


Purpose
This study primarily aims to develop and solve an enhanced optimisation model for an assembly product multi-period inbound inventory routing problem (IRP). The many-to-one (inbound) model considers the bill of materials (BOM), supply failure risks (SFR) and customer demand uncertainty. The secondary objective is to study the influence of potential time-dependent model variables on the overall supply network costs based on a full factorial design of experiments (DOE).

Design/methodology/approach
A five-step solution approach is proposed to derive the optimal inventory levels, best sourcing strategy and vehicle route plans for a multi-period discrete manufacturing product assembly IRP. The proposed approach considers an optimal risk mitigation strategy by considering less risk-prone suppliers to deliver the required components in a specific period. A mixed-integer linear programming formulation was solved to derive the optimal supply network costs.

Findings
The simulation results indicate that lower demand variation, lower component price and higher supply capacity can provide superior cost performance for an inbound supply network. The results also demonstrate that increasing supply capacity does not necessarily decrease product shortages. However, when demand variation is high, product shortages are reduced at the expense of the supply network cost.

Research limitations/implications
A two-echelon supply network for a single assembled discrete product with homogeneous vehicle fleet availability was considered in this study.

Originality/value
The proposed multi-period inbound IRP model considers realistic SFR, customer demand uncertainties and product assembly requirements based on a specific BOM. The mathematical model includes various practical aspects, such as supply capacity constraints, supplier management costs and target service-level requirements. A sensitivity analysis based on a full factorial DOE provides new insights that can aid practitioners in real-life decision-making.


This research aims to identify specific endurance exercise on some physical variables and functional indicators during wrestlers' anaerobic threshold, Main study conducted using experimental approach on a random sample of (20) wrestlers from wrestling team at Faculty of Physical Education for Men, Alexandria University, experiment conducted for (10) weeks, (30) training unit, (3) units weekly.
The most important results:

Post-measurements for all physical variables (under study) were better than pre-measurements during wrestlers' anaerobic change threshold.
Post-measurements for all Functional indicators (under study) were better than pre-measurements during wrestlers' anaerobic change threshold.

Through these results, researchers recommend the following:

Using the proposed exercises program with specific endurance exercises in wrestling sport to improve physical and functional variables during wrestlers' anaerobic change threshold, and in turn improve performance level and access highest performance levels.
Using the proposed exercises program with specific endurance exercises in sports generally, and specifically in individual combat sports to improve physical and functional variables during anaerobic change threshold, and in turn improve athletes' performance level and access highest performance levels.

This study results to be communicated to Egyptian Federation of Wrestling to be benefited with during preparation of Egyptian wrestling team.


This document is designed to provide civil leaders and school administrators with a resource that will enable them to develop comprehensive contingency plans for specific emergency situations. A discussion of disaster and emergency management planning includes an outline of I. objectives of emergency planning that were established for this guide. Appendices, which make up the bulk of the document, provide: (1) definitions and general measures cg the four elements of emergency management (mitigation, preparedness, response, and recovery); (2) a list of resource documents available from the Federal Emergency Management Agency; (3) a list of special considerations essential to school emergency planning; and (4) a list of special factors that should be considered in order to enhance plan implementation throughout schools in the United States. The final appendix is a comprehensive disaster plan designed for a hypothetical high school somewhere in the United States. The plan outlines step by step procedures for administration, faculty, and students to follow when a disaster occurs during school hours as well as related educational objectives to be integrated into the grade 7-9 curriculum. (JD) *********************************************************************** * Reproductions supplied by EMS are the best that can be made * * from the original document. N *********************************************************************** PLANNING FOR SCHOOL EMERGENCIES By Dr. Daniel E. Della-Giustina U $ DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it Minor changes have been made to improve eproduction Quality Points of view or opinions stated minis docu wont do not necessarily represent of OE RI position or policy 2 "PERMISSION TO REPRODUCE THIS MATERIAL IN MICROFICHE ONLY HAS BEEN GRANTED BY F7d.L.4 3 .0-17 TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC)." PLANNING FOR SCHOOL EMERGENCIES (Planning for All Emergency Situations) Daniel E. Della-Giustina, Ph.D. West Virginia University Prepared for: Association For Research, Admir istration, Professional Councils, and Societies (The Safety Society) An Association of the American Alliance For Health, Physical Education, Recreation, and Dance Planring for School Emergencies @ Copyright 1988 ISBN 0-88314-396-8 American Alliance for Health, Physical Education, Recreation and Dance 1900 Association Drive Reston, Virginia 22091


Objective: The Neonatal Early Discharge and Family Support Programme (NEDP) was an initiative aimed at providing extended care for families whose infants had required neonatal special care, thereby allowing earlier discharge.


Present investigation was a field experiment to document the insect pests of soybean at different growth stages during rabi-summer season of 2020-21 and comparing them with the Kharif season pests in order to know the incidence pattern. Among sucking pests, leaf hoppers and thrips were causing considerable damage while whiteflies and aphids considered as minor during rabi and summer. Leaf miner and leaf folder were considered as major defoliators during rabi-summer which are replaced by Spodoptera litura and Bihar hairy caterpillar in Kharif. Among the pod borers Etiella zinckenella and Cydia ptychora were major and caused considerable damage during summer and Kharif, respectively. Stem fly was absent during early rabi while it was present in late rabi, Kharif and summer. The insect pest incidence spectrum varied in different growing seasons of soybean crop in this region.


4. Samsó, M., Feng, W., Pessah, I. N. & Allen, P. D. (2009). PLoS Biol. 7, e85. This work was sup ported by re search grants from the Slo vak Grant Agency (VEGA No. 2/0131/10 and 2/0148/14), the Slo vak Re search and De vel op ment Agency (APVV-0628-10 and APVV-0721-10) and the Brit ish Heart Foun da tion. The at ten dance of VBH at the XIII Dis cus sions in Struc tural Mo lec u lar Bi ol ogy was funded by MVTS 1520.


The soil erosion is the most serious environmental problem in watershed areas in Iran. The main factors affecting the amount of soil erosion and sediment yield include vegetation cover, topography, soil, and climate. In order to describe the areas with high soil erosion and sediment yield risks and to develop adequate erosion preventation measures in watersheds of dams, erosion and sediment yield maps should be generated considering these factors. The purpose of this study was to investigate the spatial distribution of annual soil loss and sediment yield in Cham Gardalan watershed, Ilam Province, Iran, using Revised Universal Soil Loss Equation (RUSLE) model. Remote Sensing (RS) and Geographic Information System(GIS) technologies were used for erosion and sediment yield risk mapping, based on the this model. The R-, K-, LS-, C- and P- factors were obtained from monthly and annual rainfall data, soil map of the region, 50-meter Digital Elevation Model (DEM), Remote Sensing (RS) techniques (with use of NDVI), and GIS, respectively. The mean values of the R, k-, LS-, C- and P- factors were 265.96 MJ mm ha −1 h −1 year −1 , 0.29 t h MJ -1 mm -1 , 14.31, 0.48 and 1 , respectively. The study indicated that the slope length (L) and slope steepness (S) of the RUSLE model (R 2 = 0.84) were the most effective factors controlling soil erosion in the region. The average annual soil loss and sediment yield is predicted up to 38.81 and 19.01 (t h -1 year -1 ), respectively. The measured average annual sediment yield 16.58 (t h -1 year -1 ) was very close to estimated value (19.01 t h -1 year -1 ). Moreover, the results indicated that 47.46%, 11.22%, 9.69%, 11.29%, 20.34% of the study area was under minimal, low, moderate, high and extreme actual erosion risks, respectively. Since 31.63% of the region is under high and extreme erosion risk, adoption of suitable conservation measures seems to be inevitable. The RUSLE model integrated with RS and GIS technologies has great potential for producing accurate and inexpensive erosion and sediment yield risk maps in Iran.


Here one can find a derivation of the commutator of the charge and magnetic flux in a superconducting circuit containing a Josephson junction from the commutation relation of quantum-field operators of electric field and vector potential. A commutator of the fluxes of electric and magnetic fields passing through two interlinked loops in vacuum is also evaluated and physical interpretation of the commutator is discussed.


The ageing of the population is rapidly escalating worldwide irrespective of unpredictable health challenges like climate change, emerging infectious disease, a microbe that develops drug resistance. India is also experiencing rapid socioeconomic progress and urbanization and the result of this demographic transition is population ageing. Even though there is an increase in life expectancy, there is no increase in health span, and thus increased life expectancy leads to 'expansion of morbidity'. Longer life expectancy with the expansion of morbidity could enforce a challenge to geroscience as well as a substantial health burden and a threat to the national economy.
 In normal ageing, chronological age equates to biological age but certain disease conditions accelerate biological age. Similarly, intervention with physical activity, anti-ageing nutraceuticals would slow down the rate ageing process and provide powerful benefits for longevity. The current review article is based on MeSH and free-text terms in databases such as PubMed, the Cochrane Library, and Science Direct.  This article aims to provide an overview of the concept of biological ageing with emphasis on the pathophysiology of ageing, quantification of biological ageing and the anti-ageing strategies.


AbstractAtmospheric rivers (ARs) are a dominant mechanism for generating intense wintertime precipitation along the U.S. West Coast. While studies over the past 10 years have explored the impact of ARs in, and west of, California's Sierra Nevada and the Pacific Northwest's Cascade Mountains, their influence on the weather across the intermountain west remains an open question. This study utilizes gridded atmospheric datasets, satellite imagery, rawinsonde soundings, a 449-MHz wind profiler and global positioning system (GPS) receiver, and operational hydrometeorological observing networks to explore the dynamics and inland impacts of a landfalling, flood-producing AR across Arizona in January 2010. Plan-view, cross-section, and back-trajectory analyses quantify the synoptic and mesoscale forcing that led to widespread precipitation across the state. The analyses show that a strong AR formed in the lower midlatitudes over the northeastern Pacific Ocean via frontogenetic processes and sea surface latent-hea...


The development of an accurate prognosis is an integral component of treatment planning in the practice of periodontics. Prior work has evaluated the validity of using various clinical measured parameters for assigning periodontal prognosis as well as for predicting tooth survival and change in clinical conditions over time. We critically review the application of multivariate Classification And Regression Trees (CART) for survival in developing evidence-based periodontal prognostic indicators. We focus attention on two distinct methods of multivariate CART for survival: the marginal goodness-of-fit approach, and the multivariate exponential approach. A number of common clinical measures have been found to be significantly associated with tooth loss from periodontal disease, including furcation involvement, probing depth, mobility, crown-to-root ratio, and oral hygiene. However, the inter-relationships among these measures, as well as the relevance of other clinical measures to tooth loss from periodontal disease (such as bruxism, family history of periodontal disease, and overall bone loss), remain less clear. While inferences drawn from any single current study are necessarily limited, the application of new approaches in epidemiologic analyses to periodontal prognosis, such as CART for survival, should yield important insights into our understanding, and treatment, of periodontal diseases.


This paper relies on the random matrix theory to reduce data dimension and to identify useful data sources in the unsupervised context. A so-called random matrix based principal component analysis algorithm is thus developed and then applied to the well-known 2008 PHM dataset to build efficient but less costly degradation indices. A comparison of the degradation indices obtained with and without sensors selection confirms the performances of our proposed approach.


My term as Editor of this journal has come to a conclusion. I wish to express my appreciation to Arizona State University and the College of Arts and Sciences for their support of this publication. In addition I would like to thank Professors Gaetana Marrone-Puglia and Ilona Klein who helped in the various aspects of preparing this volume XVIII of Italian Culture and the members of the Editorial Board who contributed constructive comments to the authors and gave generously of their time.


Background: Renal dysfunction is common in chronic liver diseases. The cause of renal dysfunction is either multi-organ involvement in acute conditions or secondary to advanced liver diseases. The present study was undertaken to assess the renal function test in chronic liver diseases and find out the association of alteration of renal function with gradation of liver diseases (assessed by child –pugh criteria) and find out the association of alteration of renal functions among the case of chronic liver disease of different aetiology. Methods: This prospective cross sectional study was conducted in the Department of Medicine, Shri. B. M. Patil Medical College, Hospital & Research Centre, Vijayapur during November 2016 to August 2018 with 65 case of chronic liver diseases after considering the exclusion criteria. The patient were interviewed with predesigned and pre tested schedule examined clinically followed by some laboratory investigation relevant to diagnose the aetiology of chronic liver diseases, and to assess the severity of renal dysfunction. Statistical analysis was done by appropriate statistical software including but not restricted to MS Excel, SPSS ver.20 Results: Majority of the patients were male(90.8%) and the mean age of the patients was 45.78 ±13.19 years. 72.2% patients suffered from Alcoholic liver diseases while 13.9% and 10.8% patients had chronic hepatitis B and chronic hepatitis C respectively. Two patients had Nonalcoholic steatohepatitis. It was observed that 36.9% patients had renal dysfunction and most. Conclusion: This study emphasizes the fact that we should be more vigilant when treating Chronic Liver Disease (CLD) patients, regarding their renal function, as proper screening, prevention and treatment of renal dysfunction can decrease morbidity and mortality.


The main topic of metaphysics of the Northern and Southern Dynasties is the unified interpretation of Confucianism and Taoism.Wang Bi's theory of dichotomy,setting "no" as foundation means the incompleteness of the mystery.Guo Xiang interpreted Chuang-tzu's theory and advocated that we should try to enter the "realm of freedom",considered that Confucianism and Taoism in essence will lead to the same goal.The important aspect of Guo's theory is that men's real life is the final destination of both Confucianism and Taoism and nature and men are essentially unified,making the two theories totally different and the connection is essentialism.


Focusing on the restoration of material culture associated with pilgrimages, the authors examine how a temporally distant period might be reanimated in the present – or, by contrast, retains potential to be animated but remains dormant. They compare two pilgrimage sites, both characterized by disruptive historical caesuras that define salient periods of destruction of valued eras from the past. In Walsingham (England), the key break is represented by the northern European Reformation. At this site, the medieval remains prominent in the present, where it is repeatedly re-enacted, though in the context of loss. In the Monastery of Apostolos Andreas (Cyprus), the significant caesura is more recent, referring to the de facto partition of Cyprus in 1974. Here, the fifteenth-century chapel contained within the site has not been translated into substantial signs of medieval presence or performance. Despite their differences, both cases studied in this paper demonstrate how a caesura designates the period to be recalled and given an 'afterlife'.


Directed diffusion is a data-centric communication mechanism for sensor networks. It is supported by a flexible diffusion filter framework. GPSR (greedy perimeter stateless routing) is a routing mechanism commonly used in sensor networks. This project is an effort to connect GPSR with directed diffusion. Compared with existing routing mechanisms in the diffusion platform, including push, pull and gear, GPSR has quite different qualities in performance. It is an importation addition to the diffusion platform. As a widely known protocol, GPSR is also a good benchmark for ongoing and future research works. In this project, GPSR is implemented as a filter in the diffusion platform, and we performed simulations to compare the performance of different routing mechanisms. There are two findings from simulations results: a) overall GPSR is a rather efficient routing


In the widely used open loop oil mist lubrication system, the unused oil mist, called stray mist, is vented out into the atmosphere. The stray mist contains very little oil and applications can easily meet the OSHA requirement of maximum allowable 5 mg of oil per m{sup 3} of air. However, it has been found that for some widely used oils the stray mist contains large numbers of sub-micrometer oil particles. These particles are too small to lubricate bearings and are potentially harmful to the human respiratory system. Several new lubricating oils have been developed and tested to reduce fine oil droplets in the stray mist. The best blend of oil was able to reduce the sub-micrometer particles in the stray mist by about 75% as compared to the version of this oil currently being used. This has been accomplished without any significant change in the parameters influencing the lubrication of bearings.


Polypoidal Choroidal Vasculopathy (PCV), a subtype of neovascular Age-related Macular Degenerationn (AMD) is a disease characterized by persistent, recurrent serous leakage and hemorrhage in the macular area, mostly seen in the elderly population. While contemporary science offers anti Vasculo Endothelial Growth Factor (VEG-F) monotherapy and combination with Photodynamic Therapy (PDT), the outcomes of these remain doubtful. Repeated anti-VEG-F injections not only cause a financial and mental burden on the patients with no or very little visual outcome. Chronicity paves the way to complete loss of vision due to exudative retinal detachment. Symptoms like Raktavatdristi (to visualize things as if through a column of blood), Pashyatiaasyamanaasikam (unable to recognize the faces of people around) and aaviladarshanam (blurred vision) were suggestive of Raktaja Timira (an eye disease caused by Raktadosa) associated with Kaphadushti), according to Ayurveda. A 77-year-old male patient diagnosed with PCV sought Ayurvedic treatment after being advised to undergo anti-VEG-F therapy for the 3rd time in a row. His treatment comprised internal medicines consisting of Mahatiktakakashaya, Guduchyadikashaya, Chandraprabhavati and Avipathichurna; external treatments like Pratimarshanasya with Anu tailam and Gandusha with Triphalakashaya; Kriyakalpa (eye treatments) like Seka, Vidalaka, Aschotana and Anjana karma. At the end of 3 months of Ayurvedic treatment, his visual acuity in the right eye improved to 6/6, Optical Coherence Tomography (OCT) affirmed complete normalcy of the macula and Fundus examination confirmed the absence of neovascularization. Ayurvedic treatment is effective in reversing the process of neovascularization, thereby bringing about the marked visual outcome in PCV. Such patients should be encouraged to adopt Ayurvedic treatment instead of expensive and invasive treatment procedures like intra-vitreal injections even when the absolute effects of these remain doubtful.


Management strategies to enhance or preserve nutritive value of rhizoma peanut (Arachis glabrata Benth.) would be beneficial because high plant growth rates and adverse weather at harvest often result in low nutritive value for both pastures and hay along the coastal plain of the lower Gulf Coast. The objective of this study was to determine if a 30- or 60-d harvest frequency or 0, 110, or 220 kg N ha -1 fertilization could be managed to enhance crude protein (CP) yield and nutritive value of rhizoma peanut at three locations in Louisiana. Crude protein, neutral-detergent fiber (NDF), in vitro true digestibility (IVTD), and digestible NDF (DNDF) were measured on Florigraze' rhizoma peanut grown at three Louisiana locations in 1997 and 1998. Nitrogen fertilization increased CP yield approximately 80 kg ha -1 for the 110 and 220 kg N ha -1 treatments at two locations in I of 2 yr. Nitrogen fertilization affected nutritive value at two harvests at two locations in 1998 only. However, nutritive value was consistently lower for 60-d harvests than for 30-d harvests and was more consistent. Rhizoma peanut harvested in 1997 at 30-d intervals had 50 g kg -1 greater CP, 72 g kg -1 greater IVTD, and 40 g kg -1 greater DNDF coupled with 80 g kg -1 lower NDF than rhizoma peanut harvested at 60-d intervals. Likewise, there were seasonal influences on nutritive value. Responses in CP yield and nutritive value observed in this study were influenced more by environment (primarily rainfall) than by N fertilization and harvest management.


Although the importance of supplier/buyer relationships in product innovation has been acknowledged by many researchers, empirical evidence remains scarce regarding the effects of relationships between original equipment manufacturing (OEM) suppliers and buyers on service innovation. Surveys were completed by representatives of 142 Taiwanese OEM suppliers in the electronics industry. This paper aims to broaden the understanding of service innovation as it relates to relationship learning through the development of three aspects of organizational competence that influence the competitive advantage of an OEM supplier. This study concludes that information-sharing competence, joint-innovation competence, and coordination competence have positive effects on exploitative service innovation and explorative service innovation. Additionally, there appears not to be a significant relationship between information-sharing competence and explorative service innovation. Furthermore, these two aspects of service innovation contribute to a supplier's internal competitive advantages, but only explorative service innovation contributes to a supplier's external competitive advantages. In other words, this study provides deep and clear explanations for the antecedents and effects of service innovation of OEM suppliers.


Precision medicine is emerging now provides decision making for disease treatment and prevention with the help of genome, environment and lifestyle. This study on precision medicine recommendation system mainly focuses to explore the different optimal techniques to improve and meet the objectives of the precision medicine recommendation. It focuses on the different feature selection techniques and the prediction models for effective diagnosis of the disease, improve the survival rate of the patients and also to suggest the best lifestyle practice to carryover.


Currently, much time and effort is being expended in various activities designated as having to do with mental health, without adequate information regarding the bases on which these activities depend. As one example, treatment facilities—clinics, hospitals, etc.—are created and expanded without a great deal of knowledge about the actual number of definable emotional difficulties present within a given community. As another, educational campaigns on many levels are actively encouraged without real attempts to ascertain the basic understanding possessed by the persons who are being exposed to such efforts and without follow-up on the resultant effects. On the question of the need for facilities, Leighton1has estimated that 37% of adults in a community "are psychiatric cases"; Selective Service statistics and other surveys indicate that many persons who are emotionally ill, by existing diagnostic criteria, are not under treatment in mental health facilities. Unfortunately, exact data of this sort are


Critical micelle concentrations of three antimicrobial cationic surfactants, i.e. quaternary ammonium salts [1-(ethoxycarbonyl)pentadecyl]trimethylammonium bromide, 1-hexadecylpyridinium bromide, and dimethylbenzyldodecylammonium bromide were determined by UV spectrophotometry in aqueous solutions. In the case of the first two compounds, the effect of addition of strong electrolytes KF, KCl, KBr, Kl, KSCN, and LiCI, respectively, on the decrease of CMC was also followed. The results were processed in the form of a logarithmic dependence of CMC on the total concentration and the effect of both anions and cations of the added electrolyte was discussed. The UV spectrophotometry appeared to be a useful tool for the determination of CMC's of the order 1СГ mol dm" or smaller, if the micellizing surfactant cations or at least the corre sponding counterions (in this work Brand Г) exhibited convenient spectral parameters.


I recently led a policy and research programme in ActionAid, which resulted in the publication Listening to Smaller Voices: Children in an Environment of Change. My experiences with this, and with working with SCF-Vietnam (Save the Children Fund) in Ho Chi Minh City on programmes for street children, led me to believe that there is a need for individuals and groups within organisations to share experiences, reflect on their work and gain from the insights of other researchers and practitioners. It is important to share both the positive and negative details about methods and techniques which have worked and not worked with children, but also to understand the different problems which people face in their work with children within a context of ethical principles, power relationships and the broad institutional context in which they are working.


Since the 1979 Revolution in Iran, women have been key contributors to contemporary Iranian cinema, and to a lesser extent to theater and music. Contrary to the Western belief that the veil and other aspects of male dominance completely imprison women, my research demonstrates that they have sometimes been able to find their footing in cinema, theater and music. This paper traces the efforts these women have made. It outlines a frame of reference for the study of Iranian women under the Islamic Republic. Despite sometimes severe censorship, Iranian womens roles in the performing arts have been remarkably diverse in approach and style, and have represented extraordinarily powerful and unexpected visions of contemporary life.


This study attempts to measure state executives' regard for authoritarian values, using questionnaire responses from a sample of high-level administrators in seven states as a data base. The findings reveal considerable support for authoritarian notions, and further analysis indicates the level varies according to education, agency affiliation, and length of state service.


Juan de Manozca was the grand inquisitor of the American Inquisition. More than seventy years old when he died on 12 December 1650, he had spent forty years in service to the Holy Office, almost al...


This paper focuses on the recognition and analysis of text embedded in scene images using Deep learning. The proposed approach uses deep learning architectures for automated higher order feature extraction, thereby improving classification accuracies in comparison to handcrafted features used traditionally. Exhaustive experiments have been performed with Deep Belief Networks and Convolutional Deep Neural Networks with varied training algorithms like Contrastive Divergence, De-noising Score Matching and supervised learning algorithms such as logistic regression and Multi-layer perceptron. These algorithms have been validated on 4 standard datasets: Chars 74K English, Chars 74K Kannada, ICDAR 2003 Robust OCR dataset and SVT-CHAR dataset. The proposed network achieves improved recognition results on Chars74K English, Kannada and SVT-CHAR dataset in comparison to the state-of-art algorithms. For ICDAR 2003 dataset, the proposed network is marginally worse in comparison to Deep Convolutional networks. Although deep belief networks have been considerably used for several applications, according to the knowledge of the authors, this is the first paper to report scene text recognition using deep belief networks.


Abstract We propose a specification test for conditional location–scale models based on extremal dependence properties of the standardized residuals. We do so comparing the left-over serial extremal dependence—as measured by the pre-asymptotic tail copula—with that arising under serial independence at different lags. Our main theoretical results show that the proposed Portmanteau-type test statistics have nuisance parameter-free asymptotic limits. The test statistics are easy to compute, as they only depend on the standardized residuals, and critical values are likewise easily obtained from the limiting distributions. This contrasts with some extant tests (based, e.g., on autocorrelations of squared residuals), where test statistics depend on the parameter estimator of the model and critical values may need to be bootstrapped. We show that our tests perform well in simulations. An empirical application to S&P 500 constituents illustrates that our tests can uncover violations of residual serial independence that are not picked up by standard autocorrelation-based specification tests, yet are relevant when the model is used for, for example, risk forecasting.


Abstract Background The incidence of drug shortages has surged in recent years and it poses a major threat to public health worldwide. It can also downgrade the quality of care provided to patients. Data concerning shortages pertinent to mental health care are scarce, while treatment continuity is vital to avert disease recurrence and deterioration of patients' mental health. Objective The scope of this study is to elucidate the attitudes and perceptions of mental health professionals regarding drug shortages in Cyprus in a tertiary health institute, through a specially designed questionnaire. Results The most frequently reported effects of psychiatric drug shortages were the impaired efficacy of the alternative therapeutic regimen, re-admission of patients, delays in care provision and increased frequency of adverse events. Concerning the loss of working hours in managing drug shortages, the majority responded that they dedicate 1 to 5 working hours to this per week. Informing the patient about alternative medication and the ongoing shortages were the first strategies to minimise the effects of shortages, as attested by 74% and 72% of responders, respectively. The proposed solutions for drug shortages included thorough investigation of the root causes, the elaboration of an e-based database, drawing up a national annual report and assuming legal responsibility of pharmaceutical companies. Drug shortages constitute an important burden in the field of mental health care in Cyprus. Given the serious impact of the problem and the externalities of mental health disorders, appropriate measures must be swiftly taken to ensure timely and effective administration of the appropriate therapeutic regimen.


Meteorological disasters seriously endanger bullet trains running in high speed, so this paper puts forward a design of meteorological monitoring system for high-speed railway (MMSHSR). The system monitors meteorological disasters to ensure bullet train to run safely and efficiently. Consisting of automatic weather stations (AWS), GPRS network, Internet, monitoring center, LAN, etc., this system automatically collected meteorological parameters, sent them to the GPRS network by the GPRS module. Receiving terminal received these parameters and sent to the monitoring center, which processed these parameters, sent them to railway departments through Internet which managed the train operation according to these parameters, to improve the traffic safety and efficiency. The paper discusses in detail the overall design, AWS hardware design and the system software design.


INTRODUCTION: Cardiovascular diseases (CVD) are the main causes of death in Brazil, being the coronary arterial disease (CAD) a major cause of death and disability. The hyperlipidemia is considered an important cardiovascular risk factor, contributing to the oxidation of low density cholesterol (LDL-c), caused by the oxidative stress present in CAD. Several studies have demonstrated the beneficial effect of nuts consumption in CAD, by reducing total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c). Recent studies have demonstrated that Brazil nuts supplementation is able to improve the lipid profile in individuals with chronic non-communicable diseases. OBJECTIVES: To evaluate the effect of Brazil nut supplementation on the lipid profile and atherogenic risk in CAD patients. METHODOLOGY: Forty-two patients (63,4±7,2 years) from Rio de Janeiro, Brazil were studied. The patients were randomized in two groups: One group of patients received one nut daily (n=25) during three months, and the control group (n=17) did not receive any supplementation during three months. The diet analysis, anthropometric and biochemical measures, were determined before and after three months of supplementation, including the lipid profile, using Bioclin® kits, atherogenic risk, after calculating the Castelli I and II indexes and lipid peroxidation, estimated by determination of thiobarbituric acid reactive substances. RESULTS: The supplementation with one Brazil nut promoted a significantly decreased in TC and LDL-c levels after three months supplementation (p=0.04; p=0.04, respectively) while the control group did not shown any changes in this parameters. Furthermore, the Brazil nut supplementation improved the atherogenic risk, calculated by the Castelli Index I (p=0.03) and the oxidative stress, by decreasing the lipid peroxidation (p=0.04). CONCLUSION: These data suggest that the consumption of only one Brazil nut per day during three months was effective to reduce the TC, LDL-c, atherogenic risk and lipid peroxidation in CAD patients


This paper analyzes the characters and modes of distributed GIS, and the advantage and key technology of J2EE for construct Distributed GIS, presents an instance of distributed GIS for agriculture based on J2EE.


We study the influence of a magnetic flux tube on the possibility to electrostatically confine electrons in a graphene quantum dot. Without magnetic flux tube, the graphene pseudospin is responsible for a quantization of the total angular momentum to half-integer values. On the other hand, with a flux tube containing half a flux quantum, the Aharonov-Bohm phase and Berry phase precisely cancel, and we find a state at zero angular momentum that cannot be confined electrostatically. In this case, true bound states only exist in regular geometries for which states without zero-angular-momentum component exist, while non-integrable geometries lack confinement. We support these arguments with a calculation of the two-terminal conductance of a gate-defined graphene quantum dot, which shows resonances for a disc-shaped geometry and for a stadium-shaped geometry without flux tube, but no resonances for a stadium-shaped quantum dot with a $\pi$-flux tube.


The benefits and advantages of using millimeter wave (mm wave) draws its attention towards the 5G, cellular and other wireless communication applications. In this case, the carrier arise from the potential for larger bandwidths as compared to lower carrier frequency beam forming and equalization. The wireless networks are recommended as a complement for mobile network because of their scalability and implementation ease as like creating the hotspot on the basis of MIMO antennas. the 5G mobile communication network is used for the presentation of distribution on network architecture. This paper gives us a brief review on the mm waves of mobile networks as well as its implications on 5G. The high directivity and prone to noise makes mm waves best suitable for 5G and other wireless communication techniques. Further, the generation of these waves along with the hardware designs are less complex and reliable as compared with micro waves communication.


The microwave spectrum of gaseous nitrosoethane has been measured in the 7–40 GHz region. The monomeric vapour is shown to exist as two rotational isomers, one the cis form with a planar heavy-atom structure, the other a staggered gauche conformer. The microwave spectrum of gauche-nitrosoethane shows large centrifugal distortion shifts and additional splitting arising from tunnelling through the trans barrier. Relative intensity measurements show the cis to be more stable than the gauche form by 2.1 ± 0.4 kJ mol–1. The dipole moments were determined through the Stark effect: µa= 2.316 (2), µb= 0.623 (4) and µt= 2.398 (2) D (1 D ≈ 3.33564 × 10–30 C m) for the 15N cis, and µa= 2.288 (4), µb= 0.814 (5), µc= 0.460 (9) and µt= 2.471 (4) D for the 15N gauche form. Nitrogen-14 quadrupole coupling constants have been determined to be χaa=–2.525 (56) and (χbb–χcc)=–7.311 (97) MHz for the cis, and (χbb–χcc)= 3.518 (40) MHz for the gauche conformer.Molecular structures have been calculated for both conformers on the basis of the oxygen-18, nitrogen-15 and main species data. The ∠ CCN angle opens up by 8° on going from gauche- to cis-nitrosoethane. The barrier hindering internal rotation of the methyl group is the same for both conformers within experimental error, V3= 10.9 ± 0.3 kJ mol–1 for the cis form and 10.9 ± 0.3 kJ mol–1 for the gauche conformer.


ABSTRACT This essay argues that William Wordsworth and Letitia Elizabeth Landon (L.E.L.) use the lyrical ballad genre to formalize and conceptualize imaginative revenge, a pleasurable form of retaliation particularly suitable for everyday life that involves punishing one's foe strictly in the mind without resorting to violence or physical action of any kind. Imaginative revenge takes shape in lyrical ballads through formal elements like lyric and meter, unlike the more conventional formal and thematic features of revenge literature such as plot, spectacular violence, and tragedy. In discussing Wordsworth's "Andrew Jones" (1800) and Landon's "Revenge" (1828) as two lyrical ballads that exemplify such revenge, this essay also attends to the shared, communal potential of this otherwise private form of reprisal as well as the ways in which these poets anticipate arguments in more recent moral philosophy and affect theory about the value of negative feeling in the everyday.


Melanomas are the deadliest skin cancers, in part due to cellular plasticity and heterogeneity within the tumors. These characteristics have made a deeper understanding of melanomas challenging. Classically, melanoma cells are characterized with a limited set of protein biomarkers. Gene expression signatures and mutational analysis (e.g., BRAF and NRAS genotyping) can provide a more detailed view of heterogeneity but may not translate to readily available biomarkers for functional studies. The Deepcell platform enables multi-dimensional morphology analysis and enrichment of unlabeled single cells using artificial intelligence (AI), advanced imaging, and microfluidics, enabling high resolution profiling of population heterogeneity. Label-free multi-dimensional morphology analysis may have higher resolution than a limited set of protein biomarkers, minimizes perturbation to the transcriptome, and reduces cell handling steps. We used patient-derived cell lines and dissociated biopsy samples to train a Deepcell AI model to identify and sort for melanoma cells based on morphology alone. The model was tested on metastatic melanoma biopsies, with identification and enrichment of melanoma cells verified by various downstream assays, including scRNASeq. In addition to melanoma populations, the AI model classified various cells of the microenvironment, such as stromal cells and immune subtypes, based on morphology only. To further characterize tumor heterogeneity, we imaged >25 patient-derived melanoma cell lines representing melanocytic, mesenchymal, and intermediate phenotypic states on the Deepcell platform. Morphology analysis of these images revealed distinct clusters of cells for each phenotype, indicating that there are morphological differences associated with each state. We developed a random forest (RF) classifier to identify the top differential morphological features between the different cell lines, thereby providing a label-free means of phenotyping melanoma samples. The morphology analysis of the cell lines uncovered significant variability in pigmentation; an RF classifier distinguished between pigmented vs non-pigmented cells with >90% accuracy. Pigmentation is a hallmark of melanoma cells, and it has been associated with the melanocytic phenotype and differential drug response in vitro. However, there is not currently a robust method to profile and study pigmentation in live cells. We further investigated this observation by correlating morphological profiles, molecular, and functional information with the level of cell pigmentation. The Deepcell platform presents a new method for sorting and characterizing cellular heterogeneity using morphology, including pigmentation status. As such, multi-dimensional morphology analysis will bolster the understanding of complex melanoma states and tumor microenvironment, particularly in patient derived biopsies.
 Citation Format: Evelyn Lattmann, Aizhan Tastanova, Andreja Jovic, Kiran Saini, Tiffine Pham, Christian Corona, Jeanette Mei, Michael Phelan, Stephane C. Boutet, Ryan Carelli, Kevin B. Jacobs, Julie Kim, Manisha Ray, Chassidy Johnson, Nianzhen Li, Mahyar Salek, Maddison Masaeli, Mitchell P. Levesque. High dimensional morphology analysis reveals new insights in melanoma cell heterogeneity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5926.


Description: These activities allow students to create, identify, and describe different patterns and symmetries. Through their investigation and subsequent activities, students will begin to develop a greater understanding of patterns and symmetries. Objective: The student will be able to identify, describe, and extend/manipulate patterns. Students will also be able to identify symmetric objects. Further, students will be able to identify lines of symmetry for a particular symmetrical object. • Math Framework 1a: Represent and explain patterns using various methods. • Math Framework 1b: Identify, describe, and extend patterns. • Math Framework 2e: Identify symmetrical objects and their lines of symmetry.


In the geometrically frustrated materials with the low-dimensional and small spin moment, the quantum fluctuation could interfere with the complicated interplay of the spin, electron, lattice and orbital interactions, and host exotic ground states such as nematic spin-state and chiral liquid phase. While the quantum phases of the one-dimensional chain and S - 1/2 two-dimensional triangular-lattice antiferromagnet (TLAF) had been more thoroughly investigated by both theorists and experimentalists, the work on S = 1 TLAF has been limited. We induced the lattice distortion into the TLAFs, A3NiNb2O9 (A = Ba, Sr, and Ca) with S (Ni2+) = 1, and applied the thermodynamic, magnetic and neutron scattering measurements. Although A3NiNb2O9 kept the non-collinear 120{\deg} antiferromagnetic phase as the ground state, the Ni2+-lattice changed from the equilateral triangle (A = Ba) into isosceles triangle (A = Sr and Ca). The inelastic neutron scattering data were simulated by the linear spin-wave theory, and the competition between the single-ion anisotropy and the exchange anisotropy from the distorted lattice was discussed.


The presence of two protein-tyrosine phosphatase (PTP) domains is a striking feature in most transmembrane receptor PTPs (RPTPs). The generally inactive membrane-distal PTP domains (RPTP-D2s) bind and are proposed to regulate the membrane-proximal PTP domains (RPTP-D1s). We set out to characterize the interactions between RPTP-D1s and RPTP-D2s in vivo by co-immunoprecipitation of hemagglutinin-tagged fusion proteins encoding the transmembrane domain and RPTP-D1 and myc-tagged RPTP-D2. Seven RPTPs from four different subfamilies were used: RPTPα, RPTPε, LAR, RPTPς, RPTPδ, CD45, and RPTPμ. We found that RPTP-D2s bound to RPTPs with different affinities. The presence of intrinsic RPTP-D2 altered the binding specificity toward other RPTP-D2s positively or negatively, depending on the identity of the RPTPs. Furthermore, the C terminus of RPTP-D2s and the "wedge" in RPTP-D1s played a central role in binding specificity. Finally, full-length RPTPα and LAR heterodimerized in an oxidative stress-dependent manner. Like RPTPα-D2, the LAR-D2 conformation was affected by oxidative stress, suggesting a common regulatory mechanism for RPTP complex formation. Taken together, interactions between RPTP-D1s and RPTP-D2s are a common but specific mechanism that is likely to be regulated. The RPTP-D2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs.


518 Background: Final results from the real-world REFINE study confirmed the safety and effectiveness of regorafenib (REG) in a broad population of patients (pts) with uHCC that was consistent with the results from RESORCE, in which REG prolonged overall survival (OS) vs placebo in pts with uHCC who progressed on prior sorafenib. Here we evaluate baseline characteristics and outcomes according to the initial REG dose. Methods: REFINE (NCT03289273), an international, prospective, multicenter study, enrolled pts with uHCC for whom a decision to treat with REG was made by the treating physician prior to enrollment according to the local health authority approved label (160 mg/day, 3 weeks on/1 week off). The primary objective was safety (NCI-CTCAE v4.03); secondary endpoints included OS and progression-free survival (PFS). Results: Of 1005 pts eligible for analysis, 47%, 11%, 40%, and 3% initiated REG at 160 mg, 120 mg, 80 mg, and 40 mg, respectively. A higher proportion of pts from Asia initiated REG at 160 mg (51%) vs non-Asian countries (42%), and 67% were Child–Pugh A in Asia vs 54% in non-Asian countries at study entry. Pts initiating REG at 160 mg were more likely to be Child–Pugh A and albumin–bilirubin (ALBI) grade 1 vs pts initiating REG at <160 mg (Table). A higher proportion of pts (53%) who initiated REG at 160 mg ended prior sorafenib at 800 mg/day. Of the pts intolerant to prior sorafenib (n=91), more pts started REG at 80 mg (49%), followed by 160 mg (32%) and 120 mg (9%). Median duration of REG treatment was similar across initial dose levels (overall 3.7 months). Any-grade TEAEs were reported for 90%, 93%, and 93% of pts initiating REG at 160 mg, 120 mg, and 80 mg, respectively. TEAEs led to dose modifications in 49%, 51%, and 38% and to dose reductions in 34%, 26%, and 17% of pts. Median OS was 15.8 months in pts who initiated REG at 160 mg, 13.3 months at 120 mg, and 11.1 months at 80 mg. Median PFS was similar across doses (overall 3.9 months). Conclusions: In this real-world study, most pts with uHCC initiated REG at 160 mg or 80 mg/day. A higher proportion of pts from Asia initiated REG at the recommended dose, and a higher proportion of pts initiating REG at 160 mg had relatively better liver function at study entry. Safety was generally similar regardless of initial dose, and OS was observed to be longer in pts initiating REG at 160 mg vs lower doses. Clinical trial information: NCT03289273 . [Table: see text]


T his research aims to determine the influence of Experiential Marketing - through its dimensions, of sense, feel, think, act, and relate – and Customer Satisfaction on Customer Loyalty in Coffee Toffee Malang. This explanatory research which explains the causal relation between its existing variables through hypothesis testing. The result of this research is that four dimensions of Experiential Marketing, which are sense,  feel,  think, and  act,  have  a  positive  and  significant  effect  on  Customer Satisfaction  where  the dimension of sense is the dominant dimension, and relate has the smallest significance. Futhermore, four dimensions of Experiential Marketing, which are sense, think, act, and relate have a positive and significant effect on Customer Loyalty, where the dimension of relate is the dominant dimension, and sense has the smallest significance. The t value of the influence of Customer Satisfaction on Customer Loyalty reaches 1.972, which means that Customer Satisfaction significantly and positively influences Customer Loyalty. Keywords: Experiential Marketing, Customer's Satisfaction, Customer's Loyalty, Coffee Toffee Malang


During operation, bridge condition is decreasingdue to various effects. The condition is described
by "condition rating coefficient", determined by visual assessment. Condition of Slovenian state
road bridge network is analyzed. The condition rating database is structured with respect to
traffic load, climate zone, structural material, structural type and bridge element. Changes of
condition rating coefficient with time are presented and analyzed. Results show that climate
and exposure to water are the most important parameters influencing the condition


In this paper, we discuss the calculation of sensitivities for the cantilevered Euler-Bernoulli beam with piezoceramic patch actuators. The specific sensitivities in which we are interested are the sensitivities of the state to patch location and size. In particular, the continuous sensitivity equation method (CSEM) is applied to obtain the state sensitivities analytically via a partial differential equation. This equation is then approximated via a Galerkin finite-element scheme, and the approximations to the state and sensitivities can be computed simultaneously. Numerical results are given for a variety of patch locations and sizes.


With a steep fall in the national savings rate in developing economies attributed to external shocks and stagnation of economic growth, this study will investigate the key drivers that explain variations in the public savings rate in Kenya using time series data spanning from 1975 to 2020. Available published economic literature has only investigated the determinants of savings in industrialized economies while ignoring low-income countries. To estimate the main determinants of national savings in Kenya, the study will employ the ordinary least squares (OLS) estimation technique coupled with time series secondary data. From the estimation result, interest rate, inflation rate, income levels and consumption levels have been identified as the key drivers of the saving culture in Kenya. Public and private policymakers need to identify ways of managing these drivers to promote a higher saving behavior in Kenya.


In the 2lst century,with the development of International Society,sports educations has become a multi-direction,active course being predicated on take human as the core.So build university new style sports educational model should research multi-dimensional factors,make being unity on thought,promote from only physical reform to physical,psychological,adapt ability and existance ability developing mode.


This project presents the switched reluctancemotor (SRM) with hybrid renewable system. Switched Reluctance Motors (SRM)plays an very important role in the industrial applications, due to these advantages over conventional motors. Due to the ruggedness and simple construction this SRM motor plays a vital role in the industrial applications. They are various methods are applied for control the speed of SRM motor by the hybrid system. The hybrid system energy, has two or more renewable energy source are been used together in order to increase the efficiency of the system and to provide great balance in the system energy. The PV have different type ofcharacteristics when compared to ICEs, Maximum power point tracking (MPPT)withsolarenergyutilizationareoneuniquefeatureforthePVfed electricalvehiclesEV. Thismatterisdonewhenthemuti-objective function is applied by the proposed system which includes both Torque ripple and speed error. This controller is implemented for 4-kW SRM. In this we are combining the solar pv panels and battery. Hybrid renewable applied in energy storage systems like technoogies of battery, magnetic energy,pumped storages, capacitorsandcompressedairarethealternativesfortheoperator of an EV Electrical vehicle grid which can consume energy from energy production. The simulation results confirm by using ANFIS we can reduce the current oscillations , improve in dynamic performance and we can reduce the torqueripple


ı Supporting Information ABSTRACT: Copolymer thin fi lms of 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (V4D4), 2-(per fl uorohexylethylacry-late) (PFHEA), and 2-(per fl uoroalkylethylmethacrylate) (PFEMA) were synthesized via initiated chemical vapor deposition (iCVD) as potential candidates for gas di ff usion layers (GDLs) in gas di ff usion electrodes (GDEs) for aqueous metal − air batteries. Thin- fi lm GDLs exhibited an average water vapor transmission rate of 7.5 g m − 2 day − 1 and enhanced oxygen di ff usion with oxygen permeabilities as high as 3.53 × 10 − 15 mol m m − 2 s − 1 Pa − 1 (10.5 Barrer). The electrochemical performance of GDEs fabricated using commercial catalysts, current collectors, and synthesized GDLs was investigated by cyclic voltammetry, electrochemical impedance spectroscopy, and potentiodynamic polarization measurements. The fabricated GDEs exhibited higher oxygen reduction current densities (228.2 mA cm − 2 ) compared to commercial GDEs (132.7 mA cm − 2 ). Copolymer GLDs exhibited an order of magnitude higher oxygen di ff usion (39.5 × 10 − 8 cm 2 s − 1 ) in GDEs compared to commercial counterparts (1.84 × 10 − 8 cm 2 s − 1 Due to high solubility of V4D4 and excellent hydrophobic behavior of PFHEA PFEMA, di of materials for GDLs. Combining well-balanced properties of siloxane and fl uorinated polymer chemistries, the iCVD process is an excellent low-cost method for the fabrication of GDLs for metal − SEM analysis of iCVD GDLs, surface free energies of iCVD GDLs, oxygen permeabilities of GDLs, linear sweep voltammetry measurements, and Tafel plots of GDEs (PDF)


The objectives of this study were to examine the effects of fiber content and extrusion parameters on flax-fiber-reinforced polyethylene composites and to determine the optimum values for the same. The flax fibers were chemically pretreated, ground, and mixed with powdered polyethylene. The mixture was extruded, pelletized, ground, rotationally molded, and cut into test specimens for testing and characterization. Superposition surface methodology was then applied as optimization technique. Optimum values were fiber content = 6.25%, barrel zone temperatures = 75, 117, 127, 137, and 147 °C, and screw speed = 118 rpm for linear low-density polyethylene (LLDPE) composites; and fiber content = 5.02%, barrel zone temperatures = 75, 118, 128, 138, and 148°C, and screw speed = 126 rpm for high-density polyethylene (HDPE) composites.


Psychologists often view little children as motivationally 'innocent' and 'uncorrupted' because they seem to possess a natural curiosity about the world and an inherent desire to learn. This is, in fact, often cited as a proof that motivation to learn, just like the ability to acquire language, is an innate characteristic of the human species. Therefore, in an ideal world where the learners' curiosity and inherent motivation has not as yet been curbed or diminished by a student-unfriendly school system, all learners are eager to learn and the learning experience is a constant source of intrinsic pleasure for them. Classroom teachers in primary and secondary schools, however, tend to have perceptions that are in a sharp contrast with this idyllic view. Instead of all those keen pupils who - according to the theory - should be eagerly absorbing the morsels of wisdom offered to them, what they can see is rather reluctant youngsters who are totally unaware of the fact that there should be an innate curiosity in them, let alone a desire to learn. The regrettable fact is that if school children could freely choose what to do, academic learning for many would most likely feature very low on their agenda. Let's face it: school attendance is compulsory, and the content of the curriculum is almost always selected on the basis of what society - rather than the learners themselves - considers important (Brophy, 1998).


The aim of the study was to evaluate the prognostic value of Ki‐67, EZH2, MCM7 and EIF3S3 in prostatectomy treated patients. A retrospective population‐based material of 249 radical prostatectomy specimens on tissue microarrays was utilized. The median follow‐up of the patients was ∼5.5 years and the main end‐point was biochemical progression. The expression of Ki‐67, EZH2 and MCM7 was determined by immunohistochemistry and the gene copy number of EIF3S3 was analyzed by fluorescence in situ hybridization (FISH). In the whole material, increased immunostainings of EZH2, MCM7 and Ki‐67 were significantly associated with a high Gleason score and a short progression‐free survival. In multivariate analysis, MCM7 and Ki‐67 showed independent prognostic value with relative risks (RR) of 2.65 (95%‐confidence interval of 1.22–5.70), and 1.85 (1.14–3.01), respectively. In subgroup analysis of patients, whose treatment was evaluated to be truly radical (n = 226), EZH2 (3.14, 1.38–7.16), MCM7 (2.70, 1.16–6.30) and PSA (1.5, 1.03–2.20) showed independent prognostic value. In subgroup analysis of cases with a Gleason score <7, low Ki‐67 staining was associated with favorable prognosis with RR of 0.09 (0.01–0.69). In conclusion, Ki‐67, EZH2 and MCM7 are potential prognostic biomarkers in prostatectomy treated patients. © 2007 Wiley‐Liss, Inc.


.. Objectives: The plan of this current research was in the direction for towards the assessment of the existing ELISA (Enzyme Linked Immunosorbant Assay) method through antibodies testing for identification of hepatitis C virus disease by comparing their outcome with the Real Time polymerase chain reaction analysis. Setting: Peoples Medical College Hospital Nawabshah. Period: December 2015 to December 2016. Methods: In this current research 100 blood samples were analyzed due to the presence of anti-HCV antibodies by 3rd-generation enzyme-linked immunosorbent assay testing. All the specimens were 100% positive. Polymerase chain reaction test was performed according to the laboratory directions in antihepatitis C virus antibodies positive patients to validate the diagnosis of hepatitis C virus infectivity. Results: This research shows that, the entire results were positive by Enzyme Linked Immunosorbant Assay testing. As compared with polymerase chain reaction the of Enzyme Linked Immunosorbant Assay in this research the screening test for anti hepatitis C virus antibodies is about 2% false positive. Out of the 100 samples 98 cases are positive by Real Time polymerase chain reaction analysis while only 02 cases report are negative (2%). Conclusion: The proportion of hepatitis C virus infectivity was 100% by 3rd-generation enzyme-linked immunosorbent assay testing, 98% by Real Time polymerase chain reaction analysis. As in our research the hepatitis C virus –Ribonucleic acid is present in 98% cases who are the Antihepatitis C virus antibodies positive patients, it can be suggested that Anti-HCV antibodies detection by third generation ELISA technique in routine procedure is sufficient to determine HCV infection.


In this work, the black rice husk ash (BRHA), a pozzolanic material, was used as a partial replacement in concrete with the weight percentages of 0%, 10%, 20%, 30%, 40% and 50% for enhancing the corrosion resistivity in the marine environment. The compressive strength, corrosion by accelerated corrosion test by impressed voltage (ACTIV), and chloride (Cl−) penetration of concrete specimens were investigated after 28 days of curing. For corrosion and chloride penetration analyses, the 20% of BRHA replacement specimen was the most effective concrete specimen because the deformation was not observed within 19 days of the test. The cement specimens with lower BRHA percentages were cracked due to the development of stress by the rust formation. For higher BRHA percentages, the protective Fe2O3 was dissolved due to the acidic environment caused by higher chloride accumulation in the cement specimens. The steel rebar was then aggressively attacked by the chloride and it was finally broken. Therefore, the optimization of the BRHA percentage is needed to minimize corrosion. However, the longer curing time of 20% BRHA replacement specimen is required for increasing the compressive strength because its compressive strength is slightly lower than the standard.


Objective:To discuss the efficacy and safety of patient-controlled analgesia(PCA)by subcutaneous(PCSA)and intravenous(PCIA)injection of morphine on patients underwent total knee arthroplasty(TKA).Methods:A total of60 patients admitted into our hospital for TKA during January 2012 to March 2013 were enrolled and divided into PCIA group and PCSA group randomly.Patients in both groups underwent surgeries under epidural anesthesia.Patients in PCIA group and PCSA group were given single-dose of given 1mg and 2.5mg randomly with lock-in time being 5min and 20 min.Drugs were self-administered by patients while feeling pain.Doses,frequencies,VAPS,mean arterial pressure and respiratory rate,equanimity degree and side effects such as nausea and emesis were recorded 4,8,12 and 24hafter surgery respectively.Results:Doses in PCSA group was significantly higher than that in PCIA group 24 hafter surgery.The difference between two groups were statistical significant(P0.05).However,no differences were observed in average dosages between two groups at any point-in-time(P0.05).PCIA group had better analgesic effect than PCSA group 0-8hafter surgery(P0.05).Occurrence rates of nausea and emesis were higher in PCIA group(P0.05).Conclusion:Though both PCSA and PCIA have nice analgesic effect,PCSA works slowly and has relatively fewer side effects.Loading doses should be given before PCSA treatment so as to enhance analgesic effect in early period.


Indian Novel in English today has definitely carved a prominent place for itself in the literary world. Indian women novelists in English like Manju Kapur, Shashi Deshpande, Kamala Markandaya, Gita Hariharan and Shobha De portray the complex, dual and ambivalent identity of women engendered by a clash of tradition and modernity in their women characters. Their works no longer represent woman as a mute sufferer and upholder of traditional values but an individual who fights hard to free herself from the cages of conservative society.  Bharati Mukherjee has also been one of such writers among them and she makes an earnest effort to understand the inner dimension of the female characters.  In Miss New India, the protagonist is projected to shuffle between tradition and modern world. Not only as an epiphenomenon of modern life but also as an interpretation of idealistic woman, the novel tries to spotlight the remarkable situation of India. Confidant and determined Anjali Bose are prepared to undergo the process of racial change. Suffering from a public shame due to Sonali's divorce, Anjali's father initiates her groom hunt. This makes Anjali move from Gauripur. She considers marriage as a lifetime imprisonment that controls her and limits her beyond imagination. Her recognition may get buried in the family saga. She wants to be different from her contemporaries in ways of education and job. She gathers strength to endure the agony and pain of leaving her parents and working in an outer place. Anjali endures to assess herself, out of the circle of marriage. This paper scrutinizes the dilemma of Tradition and Modernity in Bharati Mukherjee's Miss New India.


The Single-Stranded DNA-Binding Protein (RPA) Genes in gamma ray radiation-resistant halophilic archaeon Halobacterium sp. NRC-1 were analyzed in terms of their nucleotide fluctuations. In an ATCG sequence, each base was assigned a number equal to its atomic number. The resulting numerical sequence was the basis of the statistical analysis in this study. Fractal analysis using the Higuchi method gave fractal dimensions of 2.04 and 2.06 for the gene sequences VNG2160 and VNG2162, respectively. The 16S rRNA sequence has a fractal dimension of 1.99. The di-nucleotide Shannon entropy values were found to be negatively correlated with the observed fractal dimensions (R2~ 0.992, N=3). Inclusion of Deinococcus radiodurans Rad-A in the regression analysis decreases the R2 slightly to 0.98 (N=4). A third VNG2163 RPA gene of unknown function but with upregulation activity under irradiation was found to have a fractal dimension of 2.05 and a Shannon entropy of 3.77 bits. The above results are similar to those found in bacterial Deinococcus radiodurans and suggest that their high radiation resistance property would have favored selection of CG di-nucleotide pairs. The two transcription factors TbpD (VNG7114) and TfbA (VNG 2184) were also studied. Using VNG7114, VNG2184, and VNG2163; the regression analysis of fractal dimension versus Shannon entropy shows that R2 ~ 0.997 for N =3. The VNG2163 unknown function may be related to the pathways with transcriptions closely regulated to sequences VNG7114 and VNG2184.


The public policy is a vital means that the government deals with the coordination of social benefit relation.It involves the policy choice inevitably,and the policy choice is one kind of value choice in essence.For fairness and efficiency as most basic value of community policy,it always is a dilemma choice to China government.Regardless of in personal income and in the wealth hold at present,our country income differential is rapid enlarging.Analysis from actual situation of China current,the question reason lies in lacks fairly.In order to adjust unfair,the basic way lies in the government to pay great attention to fairness and emphasize fairly for the value orientation which first considered in the community policy.


With great interest we read the article of Flott et al 1 describing the challenges of using patient-reported feedback. We recognise the challenges described and performed a bachelor project in the intensive care unit (ICU) in the University Medical Center Groningen (UMCG). We think the results from our project provide a potential promising practical solution to make feedback more useful.

In 2013 the UMCG participated in an independent multicentre study conducted among relatives of ICU patients.2 In the open questions of the questionnaire, more dissatisfaction than expected was found, which fuelled the quest for an alternative, simple and continuous feedback system. In this study we compared the quality and amount of feedback gathered by an oral survey during the first 2 weeks and an app during the consecutive 2 weeks.

Between 20 February …


For in vivo and deep-tissue imaging, near-infrared (NIR)-emitting nanoparticles (NPs) offer many advantages over visible-light-emitting NPs because the optical absorption and light scattering of biological media and tissue autofl uores-cence are minimal in the NIR region of the electromagnetic spectrum.


We give a domain-theoretic analogue of the classical Banach–Alaoglu theorem, showing that the patch topology on the weak$*$ topology is compact. Various theorems follow concerning the stable compactness of spaces of valuations on a topological space. We conclude with reformulations of the patch topology in terms of polar sets or Minkowski functionals, showing, in particular, that the 'sandwich set' of linear functionals is compact.


: The paper which deals with the design and implementation of the 3 fingered robotic hand using the voice control comments. It has special commands which may be managed the usage of voice. The robot hand can be moved in exceptional directions. The hand may be moves in a single freedom axis and the palm may be moved to close and open action. The mechanical hardware layout of the robotic hand is completed with double revolute joint mechanism. it may be used to choose the items via using the commands.The work executed by means of the robotic arm is quite precise and related the usage of Dc aspect shaft motor. As an instance a few work needs to be carried out very precisely however the conditions do now not in shape humans. In such conditions, this robot arm can be used remotely and the venture may be executed. The programming is done on Microcontroller the usage of Arduino programming.


Distributed denial of service (DDoS) attacks are one of the most common global challenges faced by service providers on the web. It leads to network disturbances, interruption of communication and significant damage to services. Researchers seek to develop intelligent algorithms to detect and prevent DDoS attacks. The present study proposes an efficient DDoS attack detection model. This model relies mainly on dimensionality reduction and machine learning algorithms. The principal component analysis (PCA) and the linear discriminant analysis (LDA) techniques perform the dimensionality reduction in individual and hybrid modes to process and improve the data. Subsequently, DDoS attack detection is performed based on random forest (RF) and decision tree (DT) algorithms. The model is implemented and tested on the CICDDoS2019 dataset using different data dimensionality reduction test scenarios. The results show that using dimensionality reduction techniques along with the ML algorithms with a dataset containing high-dimensional data significantly improves the classification results. The best accuracy result of 99.97% is obtained when the model operates in a hybrid mode based on a combination of PCA, LDA and RF algorithms, and the data reduction parameter equals 40


Theinheritance ofsixpolymorphic loci map- pingintherRNA-encoding (rDNA)region oftheinverted repeat sequence ofchloroplast DNA (cpDNA) wasscored in hybrid subclones derived fromreciprocal interspecific crosses between thegreenalgaeChlamydomonas eugametos and Chlamydomonas moewusii. Inorder toenhance thedetection of cells thathadundergone recombination between parental cpDNAs, hybrids wereselected thatinherited achloroplast antibiotic-resistance markercontributed bythemating-type- minus(mtU) parent, theparent that normally contributes fewer cpDNAmolecules. Themajorfindings ofthis study canbe summarized asfollows. (i) Themajority ofthehybrids (14/17) wererecombinant forcpDNAmarkers inthe10-kilobase-pair rDNAregion understudy. (ii) Onlyoneallele ofeachpoly- morphic cpDNAlocus waseverdetected inthehybrids, thus suggesting that newly recombined rDNAsequences inonecopy oftheinverted repeat arerapidly spread totheother bya copy-correction mechanism. (iii) Chloroplast streptomycin- resistance (sr-2) anderythromycin-resistance (er-nMI) loci, although showing little ornogenetic linkage, weremappedto the16Sand23SrRNAgeneregions ofthecpDNA,respectively, byvirtue oftheir perfect coinheritance withpolymorphic markers within these genes. (iv) cpDNAmarkers associated withaputative intron oftheC.eugametos 23SrRNAgenewere inherited byall17hybrids. Sucharesult issimilar tothat observed forcertain alleles ofthelarge rRNAgeneofyeast mitochondria incrosses between w+andwostrains. Experimental evidence forrecombination between parental chloroplast genomes during sexual reproduction islimited to thealgal genusChlamydomonas, forwhichthis process has beencharacterized bothgenetically (1-4) andphysically (5). Attempts todetect suchrecombination during sexual crosses with flowering plants havebeenunsuccessful, eveningenera suchasOenothera, whichtransmit chloroplasts atahigh frequency frombothparents (6). Recently, however, recom- bination between parental chloroplast genomeshasbeen demonstrated physically inan interspecific hybrid of Nicotiana generated byprotoplast fusion (7). This particular hybrid line wasrareinitsbeing recombinant forparental non-Mendelian genetic markers. Thecommonoccurrence of recombination between parental chloroplast genomesin Chlamydomonas crosses iscertainly related tothefact that there isfusion ofthetwoparental chloroplasts inzygotes (8). Differences intherestriction fragmentation patterns ofchlo- roplast DNA (cpDNA) fromtheinterfertile Chlamydomonas eugametos andChlamydomonas moewusii haveprovided physical markers toscoretheinheritance ofthis DNA in interspecific hybrids ofthese algae (9, 10). C.eugametos andC. moewusii matereciprocally andefficiently toformdiploid zygospores, whichundergo meiosis andgerminate into four


Post-dryout heat transfer analysis was carried out considering droplet behavior by using the Lagrangian simulation method. Post-dryout heat transfer is an important heat transfer mechanism in many industrial appliances. Especially in recent Japanese BWR licensing, the standard for assessing the integrity of fuel that has experienced boiling transition is being examined. Although post-dryout heat transfer analysis is important when predicting wall temperature, it is difficult to accurately predict the heat transfer coefficient in the post-dryout regime because of the many heat transfer paths and non-equilibrium status between droplet and vapor. Recently, an analysis model that deals with many heat transfer paths including droplet direct contact heat transfer was developed and its results showed good agreement with experimental results. The model also showed that heat transfer by droplet could not be neglected in the low mass flux condition. However, the model deals with droplet deposition behavior by experimental droplet deposition correlation, so it cannot estimate the effect of droplet flow on turbulent flow field and heat transfer. Therefore, in this study we deal with many droplets separately by using the Lagrangian simulation method and hence estimate the effect of droplet flow on the turbulent flow field. We analyzed post-dryout experimental results and found that they correlated well with the analysis results.


The invention discloses a selenium-rich Chinese yam beautifying eye mask, which comprises the main materials of selenium-rich Chinese yam fine powder, propolis liquid, common yam rhizome powder and milk, and the selenium-rich Chinese yam beautifying eye mask is characterized by particularly comprising the following materials in parts by weight: 2-4 parts of selenium-rich Chinese yam fine powder, 0.2-0.4 part of propolis liquid, 1-3 parts of common yam rhizome powder, 1-3 parts of milk, 0.08-0.12 part of essence, 0.08-0.12 part of aluminum hydroxide and 0.3-0.7 part of vegetable oil. The selenium-rich Chinese yam beautifying eye mask has the functions of moistening eye skin, eliminating infraorbital dark circles, and recovering luster, is simple to manufacture, good in effects and convenient to use by common civilians.